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+{
+	"12409": {"label": 1, "data": {"text": "Cerebrovascular Dilation via Selective Targeting of the Cholane Steroid-Recognition Site in the BK Channel \u03b21-Subunit by a Novel Nonsteroidal Agent.", "entity1": "BK Channel \u03b21-Subunit", "entity2": "Steroid", "span1": [96, 117], "span2": [64, 71]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9297": {"label": 8, "data": {"text": "We conclude that expression of GLUT2 is required for efficient killing of neuroendocrine cells by STZ, and this effect is related to specific recognition of the drug as a transported substrate by GLUT2 but not GLUT1.", "entity1": "GLUT2", "entity2": "STZ", "span1": [31, 36], "span2": [98, 101]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, 8, -1, -1, -1, 9]},
+	"10500": {"label": 1, "data": {"text": "Responses to isoproterenol could be restored to normal by beta2AR blockade, suggesting a beta2AR-mediated inhibition of beta1AR signalling.", "entity1": "beta2AR", "entity2": "isoproterenol", "span1": [58, 65], "span2": [13, 26]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2248": {"label": 3, "data": {"text": "BACKGROUND: Since the introduction of the first cholinesterase inhibitor (ChEI) in 1997, most clinicians and probably most patients would consider the cholinergic drugs, donepezil, galantamine and rivastigmine, to be the first line pharmacotherapy for mild to moderate Alzheimer's disease.The drugs have slightly different pharmacological properties, but they all work by inhibiting the breakdown of acetylcholine, an important neurotransmitter associated with memory, by blocking the enzyme acetylcholinesterase.", "entity1": "cholinesterase", "entity2": "rivastigmine", "span1": [48, 62], "span2": [197, 209]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8027": {"label": 1, "data": {"text": "In addition, we provide evidence that apomorphine also acts on endogenous TRPA1 in cultured dorsal root ganglion neurons from rats and in the enterochromaffin model cell line QGP-1, from which serotonin is released upon activation of TRPA1.", "entity1": "TRPA1", "entity2": "apomorphine", "span1": [74, 79], "span2": [38, 49]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12811": {"label": 1, "data": {"text": "Treatment with carvedilol is associated with a reversal of abnormal regulation of HIF-1alpha, VEGF, BNP, and NGF-beta in the hypertrophic myocardium.", "entity1": "NGF-beta", "entity2": "carvedilol", "span1": [109, 117], "span2": [15, 25]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2871": {"label": 2, "data": {"text": "We also found that TRPV1 receptors are activated by CuSO(4), ZnSO(4), and FeSO(4), three salts known to produce a metallic taste sensation.", "entity1": "TRPV1", "entity2": "ZnSO(4)", "span1": [19, 24], "span2": [61, 68]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"11250": {"label": 1, "data": {"text": "The 4',7,8-trichloro analogue (38) of mazindol was the most potent and selective ligand for HEK-hDAT cells (DAT K(i) = 1.1 nM; SERT/DAT = 1283 and NET/DAT = 38).", "entity1": "hDAT", "entity2": "mazindol", "span1": [96, 100], "span2": [38, 46]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11674": {"label": 1, "data": {"text": "The potential role of DAT as a target for AMPH and COC has been reviewed extensively.", "entity1": "DAT", "entity2": "AMPH", "span1": [22, 25], "span2": [42, 46]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7606": {"label": 5, "data": {"text": "While a number of orally active non-peptide V(2) antagonists (Vaptans); notably, Tolvaptan, Lixivaptan and Satavaptan, are currently in Phase III clinical trials; to date, only the mixed V(2)/V(1a), antagonist Conivaptan (Vaprisol), has been approved by the US FDA for clinical use (by i.v.", "entity1": "V(2)", "entity2": "Satavaptan", "span1": [44, 48], "span2": [107, 117]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"4172": {"label": 2, "data": {"text": "Firstly, in the normal human renal epithelial HK-2 cells, the measurement of the expression of 30 previously reported NRF2 target genes in response to NRF2 inducers (sulforaphane, tert-butylhydroquinone, cinnamic aldehyde, and hydrogen peroxide) showed that the aldo-keto reductase (AKR) 1C1 is highly inducible by all treatments.", "entity1": "NRF2", "entity2": "tert-butylhydroquinone", "span1": [118, 122], "span2": [180, 202]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5061": {"label": 3, "data": {"text": "Taken together, our results suggested that Rg1 protected against A\u03b225-35-induced apoptosis at least in part by two complementary GR-dependent ERK phosphorylation pathways: (1) down-regulating HIF-1\u03b1 initiated protein nitrotyrosination, and (2) inhibiting mitochondrial apoptotic cascades.", "entity1": "HIF-1\u03b1", "entity2": "Rg1", "span1": [192, 198], "span2": [43, 46]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, 3, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"66": {"label": 4, "data": {"text": "H1-receptor antagonists have been utilized, following their initial chemical synthesis in 1933, both in the treatment of conditions in which histamine is considered to be of pathogenic importance and conversely to help elucidate the role of histamine in disease, through an evaluation of their influence on disease expression.", "entity1": "H1-receptor", "entity2": "histamine", "span1": [0, 11], "span2": [241, 250]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, 8, -1]},
+	"13156": {"label": 2, "data": {"text": "We have previously demonstrated that phosphorylation of Fas-associated death domain-containing protein (FADD) at 194 serine through c-jun NH2-terminal kinase (JNK) activation sensitizes breast cancer cells to chemotherapy through accelerating cell cycle arrest at G2/M, and that Bcl-2 phosphorylation downstream of JNK/FADD plays an important role in cell growth suppression by paclitaxel.", "entity1": "FADD", "entity2": "paclitaxel", "span1": [104, 108], "span2": [378, 388]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2538": {"label": 8, "data": {"text": "We found that reduction of the carcinogenic hydroxylamines of the aromatic amine 4-aminobiphenyl (4-ABP; found in cigarette smoke) and the heterocyclic amine 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP; found in grilled meats) was indeed catalyzed by a purified system containing only human b5R and cyt b5.", "entity1": "human b5R", "entity2": "PhIP", "span1": [297, 306], "span2": [209, 213]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"2304": {"label": 1, "data": {"text": "Sulindac independently modulates extracellular signal-regulated kinase 1/2 and cyclic GMP-dependent protein kinase signaling pathways.", "entity1": "cyclic GMP-dependent protein kinase", "entity2": "Sulindac", "span1": [79, 114], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15244": {"label": 3, "data": {"text": "Furthermore, silymarin, silybin A, and silybin B (100 \u00b5M) significantly inhibited OATP-mediated estradiol-17\u03b2-glucuronide and rosuvastatin uptake into human hepatocytes.", "entity1": "OATP", "entity2": "silybin B", "span1": [82, 86], "span2": [39, 48]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11074": {"label": 1, "data": {"text": "We have examined the effects on the activities of three calmodulin-dependent enzymes (cAMP phosphodiesterase, caldesmon kinase and myosin light chain kinase) of the dihydropyridine Ca2+ channel blocker felodipine and three analogues (p-chloro, oxidized and t-butyl) exhibiting different pharmacological potencies.", "entity1": "myosin light chain kinase", "entity2": "p-chloro", "span1": [131, 156], "span2": [234, 242]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6145": {"label": 3, "data": {"text": "Treatment using a combination of testosterone and the aromatase inhibitor testolactone may have significantly better effects on sexual function and also seizure frequency than testosterone alone.", "entity1": "aromatase", "entity2": "testolactone", "span1": [54, 63], "span2": [74, 86]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8350": {"label": 4, "data": {"text": "Discovery of a novel series of quinolone \u03b17 nicotinic acetylcholine receptor agonists.", "entity1": "\u03b17 nicotinic acetylcholine receptor", "entity2": "quinolone", "span1": [41, 76], "span2": [31, 40]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14852": {"label": 2, "data": {"text": "Interestingly, Acrolein increased proteins' levels of amyloid precursor protein (APP), \u03b2-secretase (BACE-1) and the amyloid \u03b2-peptide transporter receptor for advanced glycation end products, and decreased A-disintegrin and metalloprotease (ADAM) 10 levels.", "entity1": "BACE-1", "entity2": "Acrolein", "span1": [100, 106], "span2": [15, 23]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, 8, -1, 8, -1, -1]},
+	"432": {"label": 1, "data": {"text": "Ka values in nM for rauwolscine (19), WB-4101 (265), SKF-104078 (197), spiroxatrine (128), and prazosin (1531) for blocking relaxation in rat arteries were consistent with their affinities for binding at the alpha-2D adrenoceptor subtype.", "entity1": "alpha-2D adrenoceptor", "entity2": "rauwolscine", "span1": [208, 229], "span2": [20, 31]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6132": {"label": 5, "data": {"text": "We have investigated the effects of CP-99,994 [(+)-(2s,3s)-3-(2-methoxybenzylamino)-2-phenylpiperidine], a tachykinin NK1 receptor antagonist, HOE 140 (D-Arg[Hyp3,Thi5,D-Tic7,Oic8]bradykinin), a bradykinin B2 receptor antagonist, and ketotifen (4-(1-methyl-4-piperidylidene)4 H-benzo[4,5]cycloheptal[1,2-b]thiophen-10(9H)-one hydrogen fumarate), a histamine H1 receptor antagonist with mast cell-stabilizing properties, on microvascular leakage induced by gaseous formaldehyde.", "entity1": "bradykinin B2 receptor", "entity2": "(D-Arg[Hyp3,Thi5,D-Tic7,Oic8]bradykinin)", "span1": [195, 217], "span2": [151, 191]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9406": {"label": 1, "data": {"text": "Binding and transactivation assays were used to compare affinities and transcriptional activities of adapalene and tretinoin for the nuclear transcription factors, retinoic acid receptors (RARs).", "entity1": "RARs", "entity2": "adapalene", "span1": [189, 193], "span2": [101, 110]}, "weak_labels": [-1, -1, -1, 1, -1, 1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4473": {"label": 3, "data": {"text": "Catalpol also suppressed AGE-induced phosphorylation of mitogen activated protein (MAP) kinases, degradation of I\u03baB\u03b1 and the nuclear localization of NF-\u03baB.", "entity1": "mitogen activated protein (MAP) kinases", "entity2": "Catalpol", "span1": [56, 95], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15837": {"label": 1, "data": {"text": "The expression of ABCA1 and ABCG1 was induced by 24-OHC, as well as TO901317 and retinoic acid, which are ligands of the nuclear receptors LXR/RXR.", "entity1": "LXR", "entity2": "TO901317", "span1": [139, 142], "span2": [68, 76]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12695": {"label": 0, "data": {"text": "Most halogenated cysteine S-conjugates are metabolized by cysteine S-conjugate beta-lyases to pyruvate, ammonia, and an alpha-chloroenethiolate (with DCVC) or an alpha-difluoroalkylthiolate (with TFEC) that may eliminate halide to give a thioacyl halide, which reacts with epsilon-amino groups of lysine residues in proteins.", "entity1": "beta-lyases", "entity2": "lysine", "span1": [79, 90], "span2": [297, 303]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1726": {"label": 3, "data": {"text": "Ginsenosides Rb2, Rd and Rg1 significantly decreased norepinephrine and/or epinephrine-induced increase of IL-6 level in macrophage cell line (RAW 264.7).", "entity1": "IL-6", "entity2": "Ginsenosides Rb2, Rd and Rg1", "span1": [107, 111], "span2": [0, 28]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"850": {"label": 3, "data": {"text": "Troglitazone inhibited the antigen-induced production of LTB(4), C(4) and E(4) and the potency of the inhibition was comparable to that of zileuton, a specific inhibitor of 5-lipoxygenase (5-LOX) and a clinically used anti-asthmatic drug.", "entity1": "5-LOX", "entity2": "zileuton", "span1": [189, 194], "span2": [139, 147]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"2817": {"label": 3, "data": {"text": "DXM and 1400W attenuated the mRNA expression of E-selectin and iNOS induced by the costimulation of reIL-4, reTNF-alpha, and LPS.", "entity1": "iNOS", "entity2": "1400W", "span1": [63, 67], "span2": [8, 13]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"107": {"label": 5, "data": {"text": "Terfenadine and astemizole are chemically unrelated to histamine H1-receptor antagonists such as diphenhydramine and chlorpheniramine.", "entity1": "histamine H1-receptor", "entity2": "Terfenadine", "span1": [55, 76], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13993": {"label": 3, "data": {"text": "Cabozantinib (XL184) is a small-molecule kinase inhibitor with potent activity toward MET and VEGF receptor 2 (VEGFR2), as well as a number of other receptor tyrosine kinases that have also been implicated in tumor pathobiology, including RET, KIT, AXL, and FLT3.", "entity1": "kinase", "entity2": "Cabozantinib", "span1": [41, 47], "span2": [0, 12]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2696": {"label": 3, "data": {"text": "OBJECTIVES: The aim of the current study was to assess the activity of rolipram, a nonsubtype-selective PDE4 inhibitor, in several animal models predictive of antipsychotic-like efficacy and side-effect liability and to use PDE4B wild-type and knockout mice to begin to understand the subtypes involved in the activity of rolipram.", "entity1": "PDE4", "entity2": "rolipram", "span1": [104, 108], "span2": [71, 79]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3098": {"label": 1, "data": {"text": "N-(Diphenylmethyl)-2-phenyl-4-quinazolinamine (SoRI-9804), N-(2,2-diphenylethyl)-2-phenyl-4-quinazolinamine (SoRI-20040), and N-(3,3-diphenylpropyl)-2-phenyl-4-quinazolinamine (SoRI-20041) partially inhibited [(125)I]3beta-(4'-iodophenyl)tropan-2beta-carboxylic acid methyl ester (RTI-55) binding, slowed the dissociation rate of [(125)I]RTI-55 from the DAT, and partially inhibited [(3)H]dopamine uptake.", "entity1": "DAT", "entity2": "RTI-55", "span1": [354, 357], "span2": [281, 287]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15252": {"label": 1, "data": {"text": "Tertiary amine-functionalized sensors adsorbed multilayers of aggregated lysozyme, whereas tertiary amine N-oxides and triethylene glycol-terminated monolayers are consistent with small protein aggregates.", "entity1": "lysozyme", "entity2": "tertiary amine N-oxides", "span1": [73, 81], "span2": [91, 114]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"656": {"label": 3, "data": {"text": "Inhibition of gelatinase A (MMP-2) by batimastat and captopril reduces tumor growth and lung metastases in mice bearing Lewis lung carcinoma.", "entity1": "MMP-2", "entity2": "batimastat", "span1": [28, 33], "span2": [38, 48]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1924": {"label": 8, "data": {"text": "In the reverse case, mutation of the orthologous glycine (Gly553) to methionine in carnitine octanoyltransferase (COT) decreased activity toward its natural substrates, medium- and long-chain acyl-CoAs, and increased activity toward short-chain acyl-CoAs.", "entity1": "COT", "entity2": "acyl-CoAs", "span1": [114, 117], "span2": [192, 201]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"223": {"label": 2, "data": {"text": "The inhibition of UG synthesis and PR down-regulation by 5 alpha-NET and 3 beta,5 alpha-NET indicates that these NET metabolites possess antiprogestational properties.", "entity1": "PR", "entity2": "5 alpha-NET", "span1": [35, 37], "span2": [57, 68]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14141": {"label": 1, "data": {"text": "In rat striatum and nucleus accumbens, mianserin stimulated [35S]GTPgammaS binding in a nor-BNI-sensitive manner with maximal effects lower than those of the full kappa-opioid agonists (-)-U50,488 and dynorphin A.", "entity1": "kappa-opioid", "entity2": "[35S]GTPgammaS", "span1": [163, 175], "span2": [60, 74]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"753": {"label": 5, "data": {"text": "The potentiation of the contractile effect induced by 5-HT is only somewhat modified by deendothelialization, but abolished by the thromboxane A2 receptor antagonists GR32191 and ridogrel.", "entity1": "thromboxane A2 receptor", "entity2": "ridogrel", "span1": [131, 154], "span2": [179, 187]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4143": {"label": 3, "data": {"text": "Here we report the re-engineering of navitoclax to create a highly potent, orally bioavailable and BCL-2-selective inhibitor, ABT-199.", "entity1": "BCL-2", "entity2": "navitoclax", "span1": [99, 104], "span2": [37, 47]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5898": {"label": 1, "data": {"text": "Probucol acts by a newly described mechanism, i.e. accelerating reverse transport of cholesteryl esters from high-density lipoproteins to lower-density lipoproteins.", "entity1": "lower-density lipoproteins", "entity2": "Probucol", "span1": [138, 164], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"2113": {"label": 1, "data": {"text": "Western blot analysis was used to determine any effect of DEC on the production of COX and inducible nitric-oxide synthase (iNOS) proteins.", "entity1": "iNOS", "entity2": "DEC", "span1": [124, 128], "span2": [58, 61]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"1587": {"label": 3, "data": {"text": "The acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities of a series of pyrano[2,3-b]quinolines (2, 3), [1,8]naphthyridines (5, 6), 4-amino-2,3-diaryl-5,6,7,8-tetrahydrofuro[2,3-b]quinolines (11-13)/ 4-amino-6,7,8,9-tetrahydro-2,3-diphenyl-5H-cyclohepta[e]furo[2,3-b]pyridine (14), 4-amino-5,6,7,8-tetrahydro-2,3-diphenylthieno[2,3-b]quinoline (15)/ 4-amino-6,7,8,9-tetrahydro-2,3-diphenyl-5H-cyclohepta[e]thieno[2,3-b]pyridine (16) are described.", "entity1": "AChE", "entity2": "4-amino-5,6,7,8-tetrahydro-2,3-diphenylthieno[2,3-b]quinoline", "span1": [26, 30], "span2": [313, 374]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3034": {"label": 8, "data": {"text": "Both risperidone and 9-hydroxyrisperidone are substrates of P-glycoprotein (P-gp), a transport protein involved in drug absorption, distribution, and elimination.", "entity1": "P-gp", "entity2": "9-hydroxyrisperidone", "span1": [76, 80], "span2": [21, 41]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, 8, -1, -1, -1, -1]},
+	"16052": {"label": 3, "data": {"text": "All HIV PIs except nelfinavir are coadministered with a low dose of ritonavir, a potent CYP3A inhibitor to improve their pharmacokinetic properties.", "entity1": "CYP3A", "entity2": "ritonavir", "span1": [88, 93], "span2": [68, 77]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12912": {"label": 8, "data": {"text": "CO treatment also inhibited LPS-induced NO production and iNOS expression via its inactivation of NF-kappaB.", "entity1": "iNOS", "entity2": "NO", "span1": [58, 62], "span2": [40, 42]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"2033": {"label": 7, "data": {"text": "The activation appears to be due to an increase of GAD affinity for its cofactor, pyridoxal phosphate (PLP).", "entity1": "GAD", "entity2": "PLP", "span1": [51, 54], "span2": [103, 106]}, "weak_labels": [-1, -1, -1, -1, -1, 1, 2, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 7, -1, -1, -1, -1, -1, -1]},
+	"12402": {"label": 2, "data": {"text": "On the basis of these findings, we conclude that HEP and HCB have additive and synergistic effects on the development of GST-P-positive foci and that higher risks are associated with a combination of residual organochlorine pesticides in foods than with individual residual organochlorine pesticides.", "entity1": "GST-P", "entity2": "HEP", "span1": [121, 126], "span2": [49, 52]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8393": {"label": 3, "data": {"text": "Acute intoxication with Cd was also followed by significantly decreased activity of the antioxidant defence system (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione (GSH), and glutathione-S-transferase (GST)).", "entity1": "GSH-Px", "entity2": "Cd", "span1": [184, 190], "span2": [24, 26]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11": {"label": 1, "data": {"text": "Iloprost was the most potent: 50% inhibition occurred at 5 nM, a concentration close to the reported dissociation constant for iloprost binding to the platelet prostacyclinprostacyclin receptor.", "entity1": "prostacyclin receptor", "entity2": "prostacyclin", "span1": [172, 193], "span2": [160, 172]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3310": {"label": 1, "data": {"text": "The main findings from this study were as follows: 1) cTnC mutants demonstrated distinct functional phenotypes reminiscent of bona fide HCM, RCM, and DCM mutations; 2) a region in cTnC associated with increased Ca(2+) sensitivity in skinned fibers was identified; and 3) the F27W reporter mutation affected Ca(2+) sensitivity, maximal force, and ATPase activation of some mutants.", "entity1": "cTnC", "entity2": "Ca(2+)", "span1": [54, 58], "span2": [211, 217]}, "weak_labels": [-1, -1, 0, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"9331": {"label": 1, "data": {"text": "Cell lines stably expressing EAA3a protein formed homomeric ligand-gated ion channels responsive, in order of decreasing affinity to domoate, kainate, L-glutamate and (RS)-alpha-amino-3-hydroxy-5- methylisoxazole-propionate (AMPA).", "entity1": "EAA3a", "entity2": "AMPA", "span1": [29, 34], "span2": [225, 229]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2772": {"label": 3, "data": {"text": "The chemical identity and position of the substituents on the lower aniline ring were important in determining the potency and extent of COX inhibition as well as COX-2 selectivity.", "entity1": "COX", "entity2": "aniline", "span1": [137, 140], "span2": [68, 75]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3917": {"label": 3, "data": {"text": "N-alkylation of the pyridazinone ring markedly enhances potency against PDE4 but suppresses PDE3 inhibition.", "entity1": "PDE4", "entity2": "N", "span1": [72, 76], "span2": [0, 1]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6638": {"label": 5, "data": {"text": "alpha(1A)-Adrenoceptor selective antagonists, 2-([2,6-dimethoxyphenoxyethyl]aminomethyl)-1,4-benzodioxane (WB-4101; 0.1-1 mg/kg) and 5-methylurapidil (0.1-1 mg/kg), the alpha(1B)-adrenoceptor selective antagonist, 4-amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6,7-dimethoxyquinazoline (L-765314; 0.3-1 mg/kg), as well as the alpha(1D)-adrenoceptor selective antagonist, 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione (BMY-7378; 1 mg/kg), were used to delineate the adrenoceptor subtypes involved.", "entity1": "alpha(1A)-Adrenoceptor", "entity2": "5-methylurapidil", "span1": [0, 22], "span2": [133, 149]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6901": {"label": 2, "data": {"text": "Our results demonstrate that the combination of denileukin diftitox and bexarotene is well tolerated and that even low doses (150 mg/day) of bexarotene are capable of in vivo upregulation of CD25 expression on circulating leukemia cells.", "entity1": "CD25", "entity2": "bexarotene", "span1": [191, 195], "span2": [141, 151]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5312": {"label": 9, "data": {"text": "Despite normal binding, autoactivation of mutants D22G and K23_I24insIDK was not stimulated by calcium.", "entity1": "K23_I24insIDK", "entity2": "calcium", "span1": [59, 72], "span2": [95, 102]}, "weak_labels": [-1, -1, 0, 1, -1, -1, 2, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"15666": {"label": 3, "data": {"text": "Small molecules bearing hydroxamic acid as the zinc binding group (ZBG) have been the most effective histone deacetylase inhibitors (HDACi) to date.", "entity1": "HDAC", "entity2": "zinc", "span1": [133, 137], "span2": [47, 51]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1400": {"label": 3, "data": {"text": "Interestingly, gemfibrozil strongly inhibited the activation of NF-kappaB, AP-1, and C/EBPbeta but not that of GAS in cytokine-stimulated astroglial cells.", "entity1": "C/EBPbeta", "entity2": "gemfibrozil", "span1": [85, 94], "span2": [15, 26]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"2918": {"label": 3, "data": {"text": "Existing ion channel blockers, such as amiodarone, dronedarone, bepridil, aprindine, and cibenzoline, have been found to have an NCX inhibitory action.", "entity1": "ion channel", "entity2": "amiodarone", "span1": [9, 20], "span2": [39, 49]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1151": {"label": 8, "data": {"text": "The tyrosinetyrosine kinase inhibitor ZD1839 (\"Iressa\") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells.", "entity1": "tyrosine kinase", "entity2": "tyrosine", "span1": [12, 27], "span2": [4, 12]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15619": {"label": 3, "data": {"text": "Galangin decreased expression of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-\u03b1, interleukin (IL)-6, IL-1\u03b2, and IL-8.", "entity1": "IL-1\u03b2", "entity2": "Galangin", "span1": [120, 125], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3110": {"label": 3, "data": {"text": "Other cholinesterase inhibitors, including rivastigmine, with superior properties in terms of specificity of action and low risk of adverse effects, have now been introduced.", "entity1": "cholinesterase", "entity2": "rivastigmine", "span1": [6, 20], "span2": [43, 55]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2334": {"label": 3, "data": {"text": "However, pretreatment with agents that block late I(Na), like lidocaine, mexiletine, and RSD1235, a novel mixed ion channel blocker for the rapid pharmacologic conversion of atrial fibrillation, significantly attenuates the prolonging effects of Class III agents or those induced by ATX-II, a specific toxin that delays Na channel inactivation and amplifies late I(Na) greatly, mimicking LQT3.", "entity1": "ion channel", "entity2": "RSD1235", "span1": [112, 123], "span2": [89, 96]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1]},
+	"3284": {"label": 9, "data": {"text": "Circulating POMC peptide concentrations were unaffected, suggesting that the rapid corticosteroid inhibitory effect specifically targeted ACTH secretion from pituitary corticotrophs.", "entity1": "POMC", "entity2": "corticosteroid", "span1": [12, 16], "span2": [83, 97]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12692": {"label": 2, "data": {"text": "We show both in vitro and in vivo that low-dose theophylline enhances HDAC activity in epithelial cells and macrophages.", "entity1": "HDAC", "entity2": "theophylline", "span1": [70, 74], "span2": [48, 60]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3330": {"label": 3, "data": {"text": "Etoposide (VP-16) is a topoisomerase-II (topo II) inhibitor chemotherapeutic agent.", "entity1": "topo II", "entity2": "Etoposide", "span1": [41, 48], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"886": {"label": 9, "data": {"text": "N(5)-Substituted H(4)biopterin derivatives were not oxidized to products serving as substrates for dihydropteridine reductase and,depending on the substituent, were competitive inhibitors of phenylalanine hydroxylase: N(5)-methyl- and N(5)-hydroxymethyl H(4)biopterin inhibited phenylalanine hydroxylase, whereas N(5)-formyl- and N(5)-acetyl H(4)biopterin had no effect.", "entity1": "phenylalanine hydroxylase", "entity2": "N(5)-acetyl H(4)biopterin", "span1": [278, 303], "span2": [330, 355]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, 8, -1, -1, 8, -1, 9]},
+	"1408": {"label": 8, "data": {"text": "Gemfibrozil, a lipid-lowering drug, inhibited cytokine-induced production of NO and the expression of inducible nitric-oxide synthasenitric-oxide synthase (iNOS) in human U373MG astroglial cells and primary astrocytes.", "entity1": "inducible nitric-oxide synthase", "entity2": "nitric-oxide", "span1": [102, 133], "span2": [133, 145]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"2558": {"label": 3, "data": {"text": "Imatinib was also found to inhibit M-CSF-induced osteoclast survival as well as M-CSF-induced osteoclast bone resorbing activity, but was without effect on interleukin 1alpha (IL-1alpha) and receptor activator of nuclear factor kappa B ligand (RANKL)-induced inhibition of osteoclasts apoptosis, further supporting the hypothesis that imatinib may affect mature osteoclasts through the inhibition of c-FMS.", "entity1": "M-CSF", "entity2": "Imatinib", "span1": [35, 40], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11730": {"label": 0, "data": {"text": "The 3D-structure of HmTx consists of three conserved alpha-helices: h1 (Lys24-His34), h2 (Cys59-Asp71), and h3 (Ala80-Phe89).", "entity1": "HmTx", "entity2": "His", "span1": [20, 24], "span2": [78, 81]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5489": {"label": 1, "data": {"text": "Of the progestagens tested in this study, only norethinodrel displayed measurable but very low relative affinity for the oestrogen receptor in MCF-7 cells.", "entity1": "oestrogen receptor", "entity2": "progestagens", "span1": [121, 139], "span2": [7, 19]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1091": {"label": 3, "data": {"text": "Moreover, the rank order for potency in inhibiting acetylcholinesterase (ambenonium>neostigmine=physostigmine =tacrine>pyridostigmine=edrophonium=galanthamine >desoxypeganine>parathion>gramine) indicated that the most effective inhibitors of acetylcholinesterase also displaced [3H]-oxotremorine-M to the greatest extent.", "entity1": "acetylcholinesterase", "entity2": "gramine", "span1": [242, 262], "span2": [185, 192]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5701": {"label": 2, "data": {"text": "Our study shows that human TRPA1 is a target for apomorphine, suggesting that an activation of TRPA1 might contribute to adverse side effects such as nausea and painful injections, which can occur during treatment with apomorphine.", "entity1": "TRPA1", "entity2": "apomorphine", "span1": [95, 100], "span2": [49, 60]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8265": {"label": 5, "data": {"text": "Commercially-available 5-HT2C agonists (CP 809101, Ro 60-0175, WAY 161503, mCPP, and 1-methylpsilocin), novel\u00a04-phenyl-2-N,N-dimethyl-aminotetralin (PAT)-type 5-HT2C agonists (with 5-HT2A/2B antagonist activity), and antagonists selective for 5-HT2A (M100907), 5-HT2C (SB-242084), and 5-HT2B/2C (SB-206553) receptors attenuated the DOI-elicited-HTR.", "entity1": "5-HT2C", "entity2": "SB-242084", "span1": [261, 267], "span2": [269, 278]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, 5, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"5348": {"label": 2, "data": {"text": "These findings suggest that S1P activates the PI3K/Akt signaling pathway leading to the promotion of nuclear translocation of \u03b2-catenin in osteoblast-like cells, resulting in the upregulation of osteoptotegerin and osteoblast differentiation markers including alkaline phosphatase, probably relating to the inhibition of osteoclast formation and the mineralization, respectively.", "entity1": "osteoptotegerin", "entity2": "S1P", "span1": [195, 210], "span2": [28, 31]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 2, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14587": {"label": 1, "data": {"text": "We demonstrated that AhR protein not only functions as a downstream target of 17-AAG, but also enhances anticancer activity of 17-AAG in lung AD cells.", "entity1": "AhR", "entity2": "17-AAG", "span1": [21, 24], "span2": [78, 84]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"2377": {"label": 3, "data": {"text": "Further characterization of sorafenib revealed that this molecule was a multikinase inhibitor that targeted the vascular endothelial growth factor receptor family (VEGFR-2 and VEGFR-3) and platelet-derived growth factor receptor family (PDGFR-beta and Kit), which play key roles in tumor progression and angiogenesis.", "entity1": "vascular endothelial growth factor receptor", "entity2": "sorafenib", "span1": [112, 155], "span2": [28, 37]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7758": {"label": 2, "data": {"text": "Rescue of both impaired extinction acquisition and deficient extinction consolidation/retrieval was achieved with prior extinction training administration of valproic acid (a GABAergic enhancer and HDAC inhibitor) or AMN082 [metabotropic glutamate receptor 7 (mGlu7) agonist], while MS-275 or PEPA (AMPA receptor potentiator) failed to affect extinction acquisition in S1 mice.", "entity1": "AMPA receptor", "entity2": "PEPA", "span1": [299, 312], "span2": [293, 297]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5327": {"label": 1, "data": {"text": "Pasireotide has a receptor binding profile that is distinct from that of other somatostatin analogues, binding with high affinity to somatostatin receptor subtype 5, which is strongly over expressed in corticotroph adenoma cells.", "entity1": "somatostatin receptor subtype 5", "entity2": "Pasireotide", "span1": [133, 164], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6289": {"label": 1, "data": {"text": "(-)-Pindolol, which possesses significant affinity for 5-HT1A, 5-HT1B, and beta 1/2-adrenergic receptors (AR)s, dose-dependently increased extracellular levels of dopamine (DA) and noradrenaline (NAD) versus 5-HT, in dialysates of the frontal cortex (FCX), but not accumbens and striatum, of freely-moving rats.", "entity1": "(AR)s", "entity2": "(-)-Pindolol", "span1": [105, 110], "span2": [0, 12]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"15521": {"label": 1, "data": {"text": "A highly potent inhibition of the peroxidase catalytic reaction by NO/SNO was seen in assays employing the coupled Prx-Trx system.", "entity1": "Prx", "entity2": "SNO", "span1": [115, 118], "span2": [70, 73]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11195": {"label": 8, "data": {"text": "Previously we have proposed that regulation of asymmetric methylarginine concentration by DDAH may provide a novel mechanism for the regulation of NOS activity in vivo.", "entity1": "DDAH", "entity2": "methylarginine", "span1": [90, 94], "span2": [58, 72]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11384": {"label": 1, "data": {"text": "5-HT1B receptors, alpha2A/2C- and, to a lesser extent, alpha1-adrenoceptors mediate the external carotid vasoconstriction to ergotamine in vagosympathectomised dogs.", "entity1": "alpha1-adrenoceptors", "entity2": "ergotamine", "span1": [55, 75], "span2": [125, 135]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10644": {"label": 1, "data": {"text": "The overall saturation binding affinity for COX-2 of valdecoxib is 2.6 nM (compared with 1.6 nM for celecoxib, 51 nM for rofecoxib, and 260 nM for etoricoxib), with a slow off-rate (t(1/2) approximately 98 min).", "entity1": "COX-2", "entity2": "celecoxib", "span1": [44, 49], "span2": [100, 109]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7826": {"label": 3, "data": {"text": "Cellular release of AChE by SH-SY5Y is significantly enhanced by the muscarinic acetylcholine receptor (mAChR) agonists carbachol or muscarine, with the effect of carbachol blocked by the mAChR antagonist atropine.", "entity1": "AChE", "entity2": "atropine", "span1": [20, 24], "span2": [205, 213]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4239": {"label": 8, "data": {"text": "These findings, derived from a variety of analytical and functional approaches, provide evidence for a novel nongenomic signaling mechanism for androgen action in the microvasculature: TES-stimulated vasodilation mediated primarily by peroxynitrite formed from xanthine oxidase-generated superoxide and NO.", "entity1": "xanthine oxidase", "entity2": "peroxynitrite", "span1": [261, 277], "span2": [235, 248]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15472": {"label": 3, "data": {"text": "Active compounds, such as the nitrobenzyl analogue 6c, were found to exhibit sub-micromolar IC50 values in Bcl-2 expressing human cancer cell lines.", "entity1": "Bcl-2", "entity2": "nitrobenzyl", "span1": [107, 112], "span2": [30, 41]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8893": {"label": 4, "data": {"text": "These effects were not mimicked by oral administration of the beta 2-adrenoceptor agonist salbutamol even at high dose (52 mg/kg diet), and the effects of clenbuterol were not inhibited by addition of DL-propranolol (200 mg/kg diet).", "entity1": "beta 2-adrenoceptor", "entity2": "salbutamol", "span1": [62, 81], "span2": [90, 100]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"7579": {"label": 1, "data": {"text": "The importance of MPH chirality to central nervous system MPH receptor targeting has culminated in human imaging studies revealing that d-MPH binds specifically to striatal structures, whereas l-MPH binding is nonspecific.", "entity1": "MPH receptor", "entity2": "MPH", "span1": [58, 70], "span2": [18, 21]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15759": {"label": 3, "data": {"text": "However, the precise mechanism by which quercetin counteracts CYP2E1-mediated ethanol hepatotoxicity through HO-1 system is still remained unclear.", "entity1": "CYP2E1", "entity2": "quercetin", "span1": [62, 68], "span2": [40, 49]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14824": {"label": 3, "data": {"text": "The reversible binding of dabigatran may provide safer and more predictable anticoagulant treatment than seen with irreversible, non-covalent thrombin inhibitors, e.g.", "entity1": "thrombin", "entity2": "dabigatran", "span1": [142, 150], "span2": [26, 36]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12908": {"label": 3, "data": {"text": "While either blockage of HO activity by the HO inhibitor, tin protoporphyrin IX, or down-regulation of HO-1 expression by HO-1 small interfering RNA (siRNA) reversed the inhibitory effects of H(2)S on iNOS expression and NO production, HO-1 overexpression produced the same inhibitory effects of H(2)S. In addition, LPS-induced nuclear factor (NF)-kappaB activation was diminished in RAW264.7 macrophages preincubated with H(2)S.", "entity1": "(NF)-kappaB", "entity2": "H(2)S", "span1": [343, 354], "span2": [423, 428]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, 3, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"6332": {"label": 1, "data": {"text": "Among the current AT1 receptor antagonists, the rank order of the relative binding affinities (highest affinity = 1) is: candesartan 1, telmisartan 10, E3174 (the active metabolite of losartan) 10, tasosartan 20, losartan 50, eprosartan 100 and the prodrug candesartan cilexetil 280.", "entity1": "AT1", "entity2": "tasosartan", "span1": [18, 21], "span2": [198, 208]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3219": {"label": 3, "data": {"text": "A series of phenolic acids and phenol natural products, such as p-hydroxybenzoic acid, p-coumaric acid, caffeic acid, ferulic acid, gallic acid, syringic acid, quercetin, and ellagic acid, were investigated for their inhibitory effects against the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1).", "entity1": "carbonic anhydrase", "entity2": "syringic acid", "span1": [262, 280], "span2": [145, 158]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"8173": {"label": 1, "data": {"text": "These results demonstrate that the incoming nucleotide is unable to induce a syn-8-oxoG conformation without minor groove DNA polymerase interactions that influence templating (anti-/syn-equilibrium) of 8-oxoG while modulating fidelity.", "entity1": "minor groove", "entity2": "nucleotide", "span1": [109, 121], "span2": [44, 54]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5799": {"label": 0, "data": {"text": "A cDNA encoding the complete amino acid sequence of aminoacylase 1 (N-acylamino acid aminohydrolase, ACY-1) [EC 3.5.1.14], a dimeric metalloprotein having two Zn2+ in the molecule, which catalyzes the deacylation of N-acylated L-amino acids except L-aspartic acid, has been isolated from porcine kidney lambda gt10 cDNA library and sequenced.", "entity1": "N-acylamino acid aminohydrolase", "entity2": "amino acid", "span1": [68, 99], "span2": [29, 39]}, "weak_labels": [0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"1291": {"label": 8, "data": {"text": "BACKGROUND AND AIMS: Glutamic acid decarboxylase (GAD, EC 4.1.1.15) catalyses the conversion of glutamate to gamma-aminobutyric acid (GABA).", "entity1": "Glutamic acid decarboxylase", "entity2": "GABA", "span1": [21, 48], "span2": [134, 138]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, 8, -1]},
+	"2557": {"label": 3, "data": {"text": "Given that M-CSF signalling through c-FMS plays an important role in osteoclast biology, we speculated that blocking such a pathway with imatinib may modulate osteoclast activity.", "entity1": "c-FMS", "entity2": "imatinib", "span1": [36, 41], "span2": [137, 145]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9810": {"label": 1, "data": {"text": "METHODS AND RESULTS: The effect of intravenous ajmaline (1 mg/kg), procainamide (10 mg/kg), or flecainide (2 mg/kg) on the ECG was studied in 34 patients with the syndrome and transient normalization of the ECG (group A), 11 members of 3 families in whom a SCN5A mutation was associated with the syndrome and 8 members in whom it was not (group B), and 53 control subjects (group C).", "entity1": "SCN5A", "entity2": "procainamide", "span1": [257, 262], "span2": [67, 79]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"12476": {"label": 9, "data": {"text": "This group of drugs contains secondary or primary amines, and these results suggest that UGT2B10 preferably conjugates tertiary amines.", "entity1": "UGT2B10", "entity2": "secondary or primary amines", "span1": [89, 96], "span2": [29, 56]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15491": {"label": 0, "data": {"text": "We used whole-cell recordings of human embryonic kidney cells heterologously expressing either wild-type TRPA1 or TRPA1 with three serine-substituted cysteines crucial for electrophile activation (C621S, C641S, C665S).", "entity1": "C665S", "entity2": "serine", "span1": [211, 216], "span2": [131, 137]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9791": {"label": 3, "data": {"text": "New modes of therapy have recently been introduced, and data on the cyclooxygenase-2 (COX-2)-specific inhibitors celecoxib and rofecoxib suggest that these agents will meet the need for safe and effective therapeutic alternatives to conventional NSAIDs.", "entity1": "COX-2", "entity2": "celecoxib", "span1": [86, 91], "span2": [113, 122]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7618": {"label": 3, "data": {"text": "Lapatinib: a dual inhibitor of human epidermal growth factor receptor tyrosine kinases.", "entity1": "tyrosine kinases", "entity2": "Lapatinib", "span1": [70, 86], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9741": {"label": 1, "data": {"text": "Herein, we evaluate the interaction of the alpha(2)-AR antagonist, yohimbine, as compared to fluparoxan, at multiple monoaminergic receptors and examine their roles in the modulation of adrenergic, dopaminergic and serotonergic transmission in freely-moving rats.", "entity1": "monoaminergic receptors", "entity2": "yohimbine", "span1": [117, 140], "span2": [67, 76]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4677": {"label": 1, "data": {"text": "Using cultured human keratinocytes and diabetic rat model, the current study showed that high-glucose environment enhanced IL-8 production via epidermal growth factor receptor (EGFR) -extracelluar signal-regulated kinase (ERK) pathway in a reactive oxygen species (ROS)-dependent manner in keratinocytes.", "entity1": "EGFR", "entity2": "glucose", "span1": [177, 181], "span2": [94, 101]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"14477": {"label": 3, "data": {"text": "The reaction was inhibited by the specific CYP2D inhibitors quinine and fluoxetine.", "entity1": "CYP2D", "entity2": "fluoxetine", "span1": [43, 48], "span2": [72, 82]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"309": {"label": 5, "data": {"text": "In contrast, the D-1997-induced responses were potently and concentration-dependently antagonized by the mixed 5-HT1-like and 5-HT2 receptor antagonist methiothepin (0.01-1 microM).", "entity1": "5-HT1-like", "entity2": "methiothepin", "span1": [111, 121], "span2": [152, 164]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6208": {"label": 1, "data": {"text": "This study therefore characterized the binding of DF to the sigma receptors and NMDA-linked PCP sites and examined the anticonvulsant as well as locomotor effects of DF in mice in comparison with those of DM and DR. We found that DF, DM, and DR were relative high-affinity ligands at sigma-1 receptors (Ki=151, 205, 144 nM, respectively) while all of them were with low affinity at sigma-2 receptors (Ki=4-11 microM).", "entity1": "sigma receptors", "entity2": "DF", "span1": [60, 75], "span2": [50, 52]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8532": {"label": 2, "data": {"text": "In macrophages, levels of TNF-\u03b1, IFN-\u03b3, NO, IL-6 and IL-10 were increased by CDM used alone or in combination with HSV-2.", "entity1": "IL-10", "entity2": "CDM", "span1": [53, 58], "span2": [77, 80]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14007": {"label": 3, "data": {"text": "Cabozantinib (XL184) is a small-molecule kinase inhibitor with potent activity toward MET and VEGF receptor 2 (VEGFR2), as well as a number of other receptor tyrosine kinases that have also been implicated in tumor pathobiology, including RET, KIT, AXL, and FLT3.", "entity1": "RET", "entity2": "XL184", "span1": [239, 242], "span2": [14, 19]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10569": {"label": 1, "data": {"text": "Binding of (-)-[3H]-CGP12177 at two sites in recombinant human beta 1-adrenoceptors and interaction with beta-blockers.", "entity1": "human beta 1-adrenoceptors", "entity2": "(-)-[3H]-CGP12177", "span1": [57, 83], "span2": [11, 28]}, "weak_labels": [-1, -1, -1, 1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1727": {"label": 3, "data": {"text": "Thus, it can be suggested that the inhibitory action of ginseng saponins against the immobilization stress-induced increase of plasma IL-6 level would be in periphery; at least in part, mediated by blocking norepinephrine- and/or epinephrine-induced increase of IL-6 level in macrophage rather than in the brain.", "entity1": "IL-6", "entity2": "ginseng saponins", "span1": [134, 138], "span2": [56, 72]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14403": {"label": 3, "data": {"text": "Herein, we report the identification and characterization of 3-(5-tert-butyl-isoxazol-3-yl)-2-[(3-chloro-phenyl)-hydrazono]-3-oxo-propionitrile (ESI-09), a novel noncyclic nucleotide EPAC antagonist that is capable of specifically blocking intracellular EPAC-mediated Rap1 activation and Akt phosphorylation, as well as EPAC-mediated insulin secretion in pancreatic \u03b2 cells.", "entity1": "Rap1", "entity2": "3-(5-tert-butyl-isoxazol-3-yl)-2-[(3-chloro-phenyl)-hydrazono]-3-oxo-propionitrile", "span1": [268, 272], "span2": [61, 143]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14777": {"label": 3, "data": {"text": "ATP-dependent 2-NBDG uptake was also inhibited by the G protein \u03b2\u03b3 subunit-interacting peptide \u03b2ark-ct and by the phosphatidylinositol 3-kinase-\u03b3 (PI3K\u03b3) inhibitor AS605240.", "entity1": "PI3K\u03b3", "entity2": "AS605240", "span1": [147, 152], "span2": [164, 172]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1958": {"label": 1, "data": {"text": "In competition experiments with human lung glucocorticoid receptors we have determined the relative receptor affinities (RRA) of these substances with reference to dexamethasone (RRA = 100).", "entity1": "human lung glucocorticoid receptors", "entity2": "dexamethasone", "span1": [32, 67], "span2": [164, 177]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14218": {"label": 6, "data": {"text": "The structurally diverse opioids codeine and eseroline, like galantamine, are also nAChR-APL that have greatly diminished affinity for AChE, representing potential lead compounds for selective nAChR-APL development.", "entity1": "nAChR", "entity2": "galantamine", "span1": [193, 198], "span2": [61, 72]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13691": {"label": 2, "data": {"text": "Two imidazoquinoline molecules, imiquimod and gardiquimod, markedly activated both porcine TLR7 and TLR8 whereas only human TLR7, but not TLR8, was activated by the ligands.", "entity1": "human TLR7", "entity2": "imidazoquinoline", "span1": [118, 128], "span2": [4, 20]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"13217": {"label": 3, "data": {"text": "Triflusal (30 mg/kg) also significantly decreased the protein levels of IL-Ibeta but not nuclear factor kappa B or tumor necrosis factor-alpha in the cortex ipsilateral to the middle cerebral artery occlusion.", "entity1": "IL-Ibeta", "entity2": "Triflusal", "span1": [72, 80], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"3603": {"label": 1, "data": {"text": "We found distinct differences in the action of ifenprodil at GluN1/GluN2B in comparison with previous studies on the effect of zinc on GluN1/GluN2A gating, which may arise due to their unique binding sites.", "entity1": "GluN2A", "entity2": "zinc", "span1": [141, 147], "span2": [127, 131]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5628": {"label": 8, "data": {"text": "BACKGROUND: Norepinephrine transporter (NET) is involved in the regulation of norepinephrine (NE) turnover and metabolism.", "entity1": "NET", "entity2": "NE", "span1": [40, 43], "span2": [94, 96]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"12347": {"label": 8, "data": {"text": "CYP3A5, which is particularly relevant to GC metabolism in the lungs, was also shown to efficiently metabolize triamcinolone acetonide, budesonide, and fluticasone propionate.", "entity1": "CYP3A5", "entity2": "budesonide", "span1": [0, 6], "span2": [136, 146]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1145": {"label": 3, "data": {"text": "ZD1839 (\"Iressa\"), a quinazoline tyrosine kinase inhibitor selective for the EGFR, has shown good activity in preclinical studies and in the early phase of clinical trials.", "entity1": "EGFR", "entity2": "Iressa", "span1": [77, 81], "span2": [9, 15]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2088": {"label": 3, "data": {"text": "Am80 slightly inhibited the growth of both myeloma cells and HUVECs, and remarkably inhibited the growth of HUVECs stimulated by VEGF.", "entity1": "VEGF", "entity2": "Am80", "span1": [129, 133], "span2": [0, 4]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14267": {"label": 8, "data": {"text": "Metabolism of triethylenetetramine and 1,12-diamino-3,6,9-triazadodecane by the spermidine/spermine-N(1)-acetyltransferase and thialysine acetyltransferase.", "entity1": "thialysine acetyltransferase", "entity2": "1,12-diamino-3,6,9-triazadodecane", "span1": [127, 155], "span2": [39, 72]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3435": {"label": 2, "data": {"text": "Epi increased both WNT6/Wnt6 and Cav1 expression in human GC cells and within the tumor area of a murine model of GC (CEA424-SV40 TAg).", "entity1": "WNT6", "entity2": "Epi", "span1": [19, 23], "span2": [0, 3]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7768": {"label": 1, "data": {"text": "GDC-0152 induces NF-\u03baB transcriptional activity leading to expression of several chemokines and cytokines, of which tumor necrosis factor alpha (TNF-\u03b1) is the most important for single-agent tumor activity.", "entity1": "cytokines", "entity2": "GDC-0152", "span1": [96, 105], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9337": {"label": 1, "data": {"text": "The relative potency of compounds in displacing [3H]-kainate binding to EAA3a receptor was: domoate > kainate > L-glutamate = quisqualate > 6,7-dinitroquinoxaline-2,3-dione (DNQX) = CNQX > AMPA > dihydrokainate > NMDA.", "entity1": "EAA3a", "entity2": "L-glutamate", "span1": [72, 77], "span2": [112, 123]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6639": {"label": 5, "data": {"text": "alpha(1A)-Adrenoceptor selective antagonists, 2-([2,6-dimethoxyphenoxyethyl]aminomethyl)-1,4-benzodioxane (WB-4101; 0.1-1 mg/kg) and 5-methylurapidil (0.1-1 mg/kg), the alpha(1B)-adrenoceptor selective antagonist, 4-amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6,7-dimethoxyquinazoline (L-765314; 0.3-1 mg/kg), as well as the alpha(1D)-adrenoceptor selective antagonist, 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione (BMY-7378; 1 mg/kg), were used to delineate the adrenoceptor subtypes involved.", "entity1": "alpha(1B)-adrenoceptor", "entity2": "4-amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6,7-dimethoxyquinazoline", "span1": [169, 191], "span2": [214, 330]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15614": {"label": 3, "data": {"text": "Furthermore, galangin attenuated IgE-mediated passive cutaneous anaphylaxis and the expression of histamine receptor 1 at the inflamed tissue.", "entity1": "IgE", "entity2": "galangin", "span1": [33, 36], "span2": [13, 21]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"134": {"label": 3, "data": {"text": "Felodipine and the p-chloro analogue inhibited the basal (Ca2+/calmodulin-independent) activity of cAMP phosphodiesterase as well as the calmodulin-stimulated activity.", "entity1": "calmodulin", "entity2": "p-chloro", "span1": [137, 147], "span2": [19, 27]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12915": {"label": 8, "data": {"text": "Hydrogen sulfide (H(2)S), a regulatory gaseous molecule that is endogenously synthesized by cystathionine gamma-lyase (CSE) and/or cystathionine beta-synthase (CBS) from L-cysteine (L-Cys) metabolism, is a putative vasodilator, and its role in nitric oxide (NO) production is unexplored.", "entity1": "CBS", "entity2": "H(2)S", "span1": [160, 163], "span2": [18, 23]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"6785": {"label": 3, "data": {"text": "RESULTS: Aspirin, diclofenac, indomethacin, ketoprofen, meclofenamic acid, and piroxicam had little selectivity toward COX isozymes, whereas NS398, carprofen, tolfenamic acid, nimesulide, and etodolac had more than 5 times greater preference for inhibiting COX-2 than COX-1.", "entity1": "COX-1", "entity2": "tolfenamic acid", "span1": [268, 273], "span2": [159, 174]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4519": {"label": 8, "data": {"text": "Carboxylesterases hydrolyze esters, amides, and thioesters to produce carboxylic acids and resulting alcohols, amines, and thiols, respectively.", "entity1": "Carboxylesterases", "entity2": "thiols", "span1": [0, 17], "span2": [123, 129]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"926": {"label": 3, "data": {"text": "5-Fluorouracil (5-FU), 5-fluoro-2'-deoxyuridine (FdUrd) and 5-trifluorothymidine (F3(d)Thd) are antimetabolites which are metabolized to their corresponding active forms which inhibit DNA synthesis via inhibition of thymidylate synthase (TS).", "entity1": "thymidylate synthase", "entity2": "5-FU", "span1": [216, 236], "span2": [16, 20]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9390": {"label": 3, "data": {"text": "GYKI 52466 decreased the peak amplitude of hippocampal area CA1 AMPA receptor-mediated excitatory postsynaptic currents (e.p.s.cs) (IC50 10.8 +/- 0.8 microM) with no apparent effect on response kinetics.", "entity1": "AMPA receptor", "entity2": "GYKI 52466", "span1": [64, 77], "span2": [0, 10]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5732": {"label": 5, "data": {"text": "These protective effects were abolished by glucocorticoid receptor (GR) antagonist RU486 or p-ERK inhibitor U0126 rather than estrogen receptor \u03b1 antagonist ICI 82,780.", "entity1": "GR", "entity2": "RU486", "span1": [68, 70], "span2": [83, 88]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13168": {"label": 1, "data": {"text": "The role of extranuclear signaling actions of progesterone receptor in mediating progesterone regulation of gene expression and the cell cycle.", "entity1": "progesterone receptor", "entity2": "progesterone", "span1": [46, 67], "span2": [81, 93]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8343": {"label": 3, "data": {"text": "We searched for inhibitors of HDC from the ethyl acetate extract of the petal of Filipendula ulmaria, also called meadowsweet.", "entity1": "HDC", "entity2": "ethyl acetate", "span1": [30, 33], "span2": [43, 56]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2159": {"label": 3, "data": {"text": "Thalidomide reduced COX-2 expression accompanied by a decrease of bcl-2 protein, TNFalpha, VEGF, GSH and an increased cytochrome c, but had no effect on that of COX-1, in MCF-7 and HL-60.", "entity1": "VEGF", "entity2": "Thalidomide", "span1": [91, 95], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4056": {"label": 3, "data": {"text": "In this study, focus was given to evaluate the ability of neoechinulin A, an indole alkaloid isolated from marine-derived Microsporum sp., to attenuate microglial activation by oligomeric amyloid-\u03b2 1-42 (A\u03b242).", "entity1": "amyloid-\u03b2 1-42", "entity2": "indole", "span1": [188, 202], "span2": [77, 83]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11128": {"label": 1, "data": {"text": "Prazosin was found to be unselective; 2-(2,6-dimethoxyphenoxyethyl)aminomethyl-1,4-benzodioxane (WB 4101), 5-methyl-urapidil, indoramin and (+)-niguldipine were confirmed as selective for the alpha 1A-adrenoceptor, whereas spiperone was weakly alpha 1B-selective.", "entity1": "alpha 1A-adrenoceptor", "entity2": "5-methyl-urapidil", "span1": [192, 213], "span2": [107, 124]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7388": {"label": 8, "data": {"text": "Finally, we demonstrate that T. thermophilus PRODH reacts with O(2) producing superoxide.", "entity1": "T. thermophilus PRODH", "entity2": "superoxide", "span1": [29, 50], "span2": [78, 88]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"15323": {"label": 5, "data": {"text": "IKM-159 was developed and identified as a member of a new class of heterotricyclic glutamate analogues that act as AMPA receptor-selective antagonists.", "entity1": "AMPA receptor", "entity2": "IKM-159", "span1": [115, 128], "span2": [0, 7]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5208": {"label": 3, "data": {"text": "Correlation between activation of PPAR\u03b3 and resistin downregulation in a mouse adipocyte cell line by a series of thiazolidinediones.", "entity1": "resistin", "entity2": "thiazolidinediones", "span1": [44, 52], "span2": [114, 132]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6560": {"label": 3, "data": {"text": "In contrast, the mutants T844A, F972A and Q975A showed increased K(i) for cilostazol but no difference for milrinone from the recombinant PDE3A.", "entity1": "Q975A", "entity2": "milrinone", "span1": [42, 47], "span2": [107, 116]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8248": {"label": 0, "data": {"text": "N-terminal sequencing indicated that pro-BMP-2 was cleaved by FSAP at the canonical PC cleavage site, giving rise to mature BMP-2 (Arg(282)\u2193Gln(283)), as well as in the N-terminal heparin binding region of mature BMP-2, generating a truncated mature BMP-2 peptide (Arg(289)\u2193Lys(290)).", "entity1": "BMP-2", "entity2": "Lys", "span1": [250, 255], "span2": [274, 277]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"526": {"label": 2, "data": {"text": "Next, we examined the role of Rho family GTPases in the ceramide-induced signalling to SRE activation.", "entity1": "SRE", "entity2": "ceramide", "span1": [87, 90], "span2": [56, 64]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6370": {"label": 4, "data": {"text": "The nonselective opioid receptor partial agonist buprenorphine and the nonselective opioid receptor antagonist (-)-quadazocine exhibited pure antagonism at rat brain receptors, but displayed partial agonism at human ORL1 receptors.", "entity1": "human ORL1", "entity2": "(-)-quadazocine", "span1": [210, 220], "span2": [111, 126]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8883": {"label": 2, "data": {"text": "This inhibition was mediated by a TCDD-induced secreted factor which was identified as insulin-like growth factor binding protein 4 (IGFBP-4).", "entity1": "IGFBP-4", "entity2": "TCDD", "span1": [133, 140], "span2": [34, 38]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14796": {"label": 2, "data": {"text": "Trichostatin A inhibits transforming growth factor-\u03b2-induced reactive oxygen species accumulation and myofibroblast differentiation via enhanced NF-E2-related factor 2-antioxidant response element signaling.", "entity1": "antioxidant response element", "entity2": "Trichostatin A", "span1": [168, 196], "span2": [0, 14]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5084": {"label": 3, "data": {"text": "FCEO significantly inhibited nitric oxide (NO) and prostaglandin E2 (PGE2) by suppressing the protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2, respectively.", "entity1": "iNOS", "entity2": "NO", "span1": [149, 153], "span2": [43, 45]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5736": {"label": 1, "data": {"text": "Taken together, our results suggested that Rg1 protected against A\u03b225-35-induced apoptosis at least in part by two complementary GR-dependent ERK phosphorylation pathways: (1) down-regulating HIF-1\u03b1 initiated protein nitrotyrosination, and (2) inhibiting mitochondrial apoptotic cascades.", "entity1": "ERK", "entity2": "Rg1", "span1": [142, 145], "span2": [43, 46]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, 3, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6147": {"label": 0, "data": {"text": "There are 3-4 drug binding sites in the N- and C-terminal domains of intact cTnC that exhibit fast exchange on the NMR time scale.", "entity1": "cTnC", "entity2": "C", "span1": [76, 80], "span2": [47, 48]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7980": {"label": 1, "data": {"text": "Initiating event of the mitochondrial-mediated apoptosis induced by ISO is MAPK signals.", "entity1": "MAPK", "entity2": "ISO", "span1": [75, 79], "span2": [68, 71]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13216": {"label": 1, "data": {"text": "Triflusal, a selective cyclooxygenase-2, and its active metabolite 3-hydroxy-4-trifluoromethylbenzoic acid may inhibit apoptosis and inflammation after cerebral ischemia.", "entity1": "cyclooxygenase-2", "entity2": "3-hydroxy-4-trifluoromethylbenzoic acid", "span1": [23, 39], "span2": [67, 106]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11191": {"label": 1, "data": {"text": "Neostigmine enhances excitatory parasympathetic activity by competing with acetylcholine for attachment to acetylcholinesterase at sites of cholinergic transmission and enhancing cholinergic action.", "entity1": "acetylcholinesterase", "entity2": "Neostigmine", "span1": [107, 127], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6913": {"label": 8, "data": {"text": "PSMA acts as a glutamate carboxypeptidase (GCPII) on small molecule substrates, including folate, the anticancer drug methotrexate, and the neuropeptide N-acetyl-l-aspartyl-l-glutamate.", "entity1": "GCPII", "entity2": "methotrexate", "span1": [43, 48], "span2": [118, 130]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"3654": {"label": 8, "data": {"text": "The results show that CYP2E1 inhibits CYP2B4-mediated metabolism of benzphetamine (BNZ) with a K(i) of 0.04 \u00b5M.", "entity1": "CYP2B4", "entity2": "benzphetamine", "span1": [38, 44], "span2": [68, 81]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15311": {"label": 4, "data": {"text": "for 15 days or along with a peroxisome proliferator-activated receptor alpha agonist bezafibrate (Bzf; 30\u200a\u03bcg/100\u200ag BW, oral) and were found to improve in the Bzf co-treated condition.", "entity1": "peroxisome proliferator-activated receptor alpha", "entity2": "Bzf", "span1": [28, 76], "span2": [98, 101]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1425": {"label": 0, "data": {"text": "In contrast, an NH(2)-terminal deletion mutant of K8 promoted the formation of intracellular aggregates even in the absence of K18 overexpression.", "entity1": "K8", "entity2": "NH(2)", "span1": [50, 52], "span2": [16, 21]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7136": {"label": 1, "data": {"text": "All PDE5 constructs had similar affinities for 3-isobutyl-1-methylxanthine, sildenafil, tadalafil, and UK-122764, but mutants containing a complete GAF-B had 7- to 18-fold higher affinity for vardenafil-based compounds compared with those lacking a complete GAF-B.", "entity1": "GAF-B", "entity2": "tadalafil", "span1": [148, 153], "span2": [88, 97]}, "weak_labels": [-1, -1, 0, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"583": {"label": 3, "data": {"text": "Cyclin E-cdk2 activation is associated with cell cycle arrest and inhibition of DNA replication induced by the thymidylate synthase inhibitor Tomudex.", "entity1": "thymidylate synthase", "entity2": "Tomudex", "span1": [111, 131], "span2": [142, 149]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14888": {"label": 2, "data": {"text": "Induction of HO-1 through p38 MAPK/Nrf2 signaling pathway by ethanol extract of Inula helenium L. reduces inflammation in LPS-activated RAW 264.7 cells and CLP-induced septic mice.", "entity1": "p38", "entity2": "ethanol", "span1": [26, 29], "span2": [61, 68]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3314": {"label": 1, "data": {"text": "Mutations in the Ca(2+) sensor, troponin C (TnC), were generated to increase/decrease the Ca(2+) sensitivity of cardiac skinned fibers to create the characteristic effects of DCM, HCM, and RCM.", "entity1": "troponin C", "entity2": "Ca(2+)", "span1": [32, 42], "span2": [17, 23]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15834": {"label": 1, "data": {"text": "The expression of ABCA1 and ABCG1 was induced by 24-OHC, as well as TO901317 and retinoic acid, which are ligands of the nuclear receptors LXR/RXR.", "entity1": "LXR", "entity2": "retinoic acid", "span1": [139, 142], "span2": [81, 94]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1111": {"label": 2, "data": {"text": "Indomethacin activates carbonic anhydrase and antagonizes the effect of the specific carbonic anhydrase inhibitor acetazolamide, by a direct mechanism of action.", "entity1": "carbonic anhydrase", "entity2": "Indomethacin", "span1": [85, 103], "span2": [0, 12]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15794": {"label": 8, "data": {"text": "Consistent with two glucose uptake pathways, induced uptake of 2-NBDG, a fluorescent glucose derivative, was decreased by inhibition of HCs or glucose transporter (GLUT4), and blocked by dual blockade.", "entity1": "GLUT4", "entity2": "glucose", "span1": [164, 169], "span2": [20, 27]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"2060": {"label": 2, "data": {"text": "Mutation of arginine 228 to lysine enhances the glucosyltransferase activity of bovine beta-1,4-galactosyltransferase I.\tBeta-1,4-galactosyltransferase I (beta4Gal-T1) normally transfers Gal from UDP-Gal to GlcNAc in the presence of Mn(2+) ion (Gal-T activity) and also transfers Glc from UDP-Glc to GlcNAc (Glc-T activity), albeit at only 0.3% efficiency.", "entity1": "glucosyltransferase", "entity2": "lysine", "span1": [48, 67], "span2": [28, 34]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11732": {"label": 0, "data": {"text": "The 3D-structure of HmTx consists of three conserved alpha-helices: h1 (Lys24-His34), h2 (Cys59-Asp71), and h3 (Ala80-Phe89).", "entity1": "HmTx", "entity2": "Asp", "span1": [20, 24], "span2": [96, 99]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1301": {"label": 3, "data": {"text": "OBJECTIVE: Celecoxib and rofecoxib are two relatively new nonsteroidal anti-inflammatory drugs (NSAIDs) that selectively inhibit the cyclo-oxygenase-2 (COX-2) isoenzyme at therapeutic concentrations.", "entity1": "cyclo-oxygenase-2", "entity2": "Celecoxib", "span1": [133, 150], "span2": [11, 20]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6874": {"label": 3, "data": {"text": "Also, prophylactic, as well as therapeutic, treatment with the CSE inhibitor, DL-propargylglycine (PAG), significantly reduced the severity of caerulein-induced pancreatitis and associated lung injury, as determined by 1) hyperamylasemia [plasma amylase (U/L) (control, 1204+/-59); prophylactic treatment: placebo, 10635+/-305; PAG, 7904+/-495; therapeutic treatment: placebo, 10427+/-470; PAG, 7811+/-428; P<0.05 PAG c.f.", "entity1": "CSE", "entity2": "DL-propargylglycine", "span1": [63, 66], "span2": [78, 97]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5498": {"label": 3, "data": {"text": "4) High concentrations of I- inhibited the catalatic activity of thyroid peroxidase and lactoperoxidase in a manner similar to that described previously for peroxidase-catalyzed iodination.", "entity1": "peroxidase", "entity2": "I-", "span1": [157, 167], "span2": [26, 28]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"15750": {"label": 2, "data": {"text": "Ethanol-stimulated (100mM) CYP2E1 upregulation was suppressed by quercetin but further enhanced by HO-1 inhibition with resultant heme accumulation.", "entity1": "CYP2E1", "entity2": "Ethanol", "span1": [27, 33], "span2": [0, 7]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2036": {"label": 8, "data": {"text": "L-serine dehydratase (SDH), a member of the beta-family of pyridoxal phosphate-dependent (PLP) enzymes, catalyzes the deamination of L-serine and L-threonine to yield pyruvate or 2-oxobutyrate.", "entity1": "SDH", "entity2": "pyruvate", "span1": [22, 25], "span2": [167, 175]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"8093": {"label": 3, "data": {"text": "Cell culture studies demonstrated that PKAA is capable of delivering anti-TNF (tumor necrosis factor)-\u03b1 siRNA to lipopolysaccharide (LPS)-stimulated macrophages and significantly inhibits the expression of TNF-\u03b1.", "entity1": "TNF-\u03b1", "entity2": "PKAA", "span1": [206, 211], "span2": [39, 43]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"431": {"label": 9, "data": {"text": "Forskolin did not affect the relaxant response to UK14,304, suggesting that cAMP is not involved in the coupling of alpha-2 adrenoceptors to nitric oxide-induced vascular relaxation.", "entity1": "alpha-2 adrenoceptors", "entity2": "cAMP", "span1": [116, 137], "span2": [76, 80]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"7520": {"label": 2, "data": {"text": "BACKGROUND AND PURPOSE: AMP-activated protein kinase (AMPK) is activated by metformin, phenformin, and the AMP mimetic, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR).", "entity1": "AMPK", "entity2": "5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside", "span1": [54, 58], "span2": [120, 174]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7129": {"label": 1, "data": {"text": "Binding of cGMP to GAF-A increases cNPK phosphorylation of PDE5 and improves catalytic site affinity for cGMP or inhibitors.", "entity1": "PDE5", "entity2": "cGMP", "span1": [59, 63], "span2": [105, 109]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11137": {"label": 1, "data": {"text": "For example, clozapine revealed a radioligand-independent value of 1.6 nM at the dopamine D4 receptor, agreeing with the value directly measured with [3H]-clozapine at D4.", "entity1": "dopamine D4 receptor", "entity2": "clozapine", "span1": [81, 101], "span2": [13, 22]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4975": {"label": 2, "data": {"text": "Crocin (25 and 50mg/kg) or vitamin E improved histopathological damages, decreased MDA and CK-MB, increased GSH content and attenuated the increase of Bax/Bcl2 ratio, activation of caspase 3 and release of cytochrome c to the cytosol induced by DZN.", "entity1": "caspase 3", "entity2": "DZN", "span1": [181, 190], "span2": [245, 248]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3732": {"label": 3, "data": {"text": "The present results indicated that N-BPs induce apoptosis by decreasing the mitochondrial transmembrane potential, increasing the activation of caspase-9 and caspase-3, and enhancing Bim expression through inhibition of the Ras/MEK/ERK and Ras/mTOR pathways.", "entity1": "Ras", "entity2": "BPs", "span1": [240, 243], "span2": [37, 40]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, 2, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14329": {"label": 3, "data": {"text": "Results showed that DMF increased nuclear levels of Nrf2, and both DMF and adenovirus-mediated overexpression of Nrf2 (Ad-Nrf2) decreased PAI-1, alpha-smooth muscle actin (alpha-SMA), fibronectin and type 1 collagen expression in TGF-beta-treated rat mesangial cells (RMCs) and renal fibroblast cells (NRK-49F).", "entity1": "alpha-smooth muscle actin", "entity2": "DMF", "span1": [145, 170], "span2": [67, 70]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3726": {"label": 3, "data": {"text": "The present results indicated that N-BPs induce apoptosis by decreasing the mitochondrial transmembrane potential, increasing the activation of caspase-9 and caspase-3, and enhancing Bim expression through inhibition of the Ras/MEK/ERK and Ras/mTOR pathways.", "entity1": "ERK", "entity2": "N", "span1": [232, 235], "span2": [35, 36]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, 2, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5771": {"label": 2, "data": {"text": "Resistance of TIDA neurons to MPTP toxicity was correlated with a transient increase in UCHL-1 and a sustained elevation in parkin in the arcuate nucleus.", "entity1": "UCHL-1", "entity2": "MPTP", "span1": [88, 94], "span2": [30, 34]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6483": {"label": 4, "data": {"text": "CONCLUSIONS: The alpha(2)-adrenoceptor agonists brimonidine, apraclonidine, and oxymetazoline are potent vasoconstrictors in the porcine ciliary artery.", "entity1": "alpha(2)-adrenoceptor", "entity2": "brimonidine", "span1": [17, 38], "span2": [48, 59]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6355": {"label": 5, "data": {"text": "The mode of (functional) AT1 receptor antagonism has been characterized as surmountable/noncompetitive (losartan, tasosartan, eprosartan) or insurmountable/noncompetitive (candesartan, saprisartan, zolasartan, irbesartan, valsartan, telmisartan, E3174).", "entity1": "AT1", "entity2": "tasosartan", "span1": [25, 28], "span2": [114, 124]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1197": {"label": 8, "data": {"text": "Different substrates were used as the relative specific substrates for the determination of aminopeptidase enzymatic activity: 4-methoxy-2-naphthylamide of L-alanine for aminopeptidase N, 4-methoxy-2-naphthylamide of L-leucine for leucine aminopeptidase, 4-methoxy-2-naphthylamide of L-glutamic acid for aminopeptidase A and 4-methoxy-2-naphthylamide of L-arginine for aminopeptidase B.", "entity1": "aminopeptidase A", "entity2": "4-methoxy-2-naphthylamide", "span1": [304, 320], "span2": [255, 280]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"3454": {"label": 1, "data": {"text": "RESULTS: (+/-)-, R-, and S-modafinil bind to the DAT and inhibit DA uptake less potently than cocaine, with R-modafinil having approximately threefold higher affinity than its S-enantiomer.", "entity1": "DAT", "entity2": "(+/-)-, R-, and S-modafinil", "span1": [49, 52], "span2": [9, 36]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13824": {"label": 1, "data": {"text": "Atomoxetine has a high affinity and selectivity for norepinephrine transporters, but little or no affinity for various neurotransmitter receptors.", "entity1": "norepinephrine transporters", "entity2": "Atomoxetine", "span1": [52, 79], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"9115": {"label": 1, "data": {"text": "To determine the factors that influence the interaction between phenoxybenzamine and calmodulin, the binding of phenoxybenzamine to calmodulin was determined by equilibrium dialysis under a variety of experimental conditions.", "entity1": "calmodulin", "entity2": "phenoxybenzamine", "span1": [85, 95], "span2": [64, 80]}, "weak_labels": [-1, -1, -1, 1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11983": {"label": 8, "data": {"text": "Doxorubicin is mainly excreted into the bile via P-glycoprotein (P-gp) and multidrug resistance-associated protein 2 (Mrp2) in hepatobiliary route and metabolized via cytochrome P450 (CYP) 3A subfamily.", "entity1": "cytochrome P450 (CYP) 3A", "entity2": "Doxorubicin", "span1": [167, 191], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"875": {"label": 8, "data": {"text": "Inhibition of S-adenosylmethionine decarboxylase by a specific inhibitor [diethylglyoxal bis-(guanylhydrazone); DEGBG] led to depletion of spermidine and spermine with a significant accumulation of putrescine and induction of ODC.", "entity1": "S-adenosylmethionine decarboxylase", "entity2": "spermidine", "span1": [14, 48], "span2": [139, 149]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4925": {"label": 2, "data": {"text": "This study assessed changes in myocardial ALDH2 expression in the diabetic rat, in particular the diabetic rat pretreated with ALDH2 activator ethanol (EtOH).", "entity1": "ALDH2", "entity2": "ethanol", "span1": [127, 132], "span2": [143, 150]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14127": {"label": 3, "data": {"text": "Crizotinib is an oral tyrosine kinase inhibitor (TKI), which silences the protein product of the ALK fusion gene and has recently been approved for the treatment of NSCLC aberrantly expressing ALK.", "entity1": "tyrosine kinase", "entity2": "Crizotinib", "span1": [22, 37], "span2": [0, 10]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"3480": {"label": 0, "data": {"text": "This localization is in turn dependent on the Homer family of scaffolding proteins which bind to a small motif on the distal C-termini of mGluR1 and 5, localize the receptors near the PSD, strengthen coupling to post-synaptic effectors and simultaneously uncouple the mGluRs from extra-synaptic effectors such as voltage dependent ion channels.", "entity1": "mGluR1 and 5", "entity2": "C", "span1": [138, 150], "span2": [125, 126]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8915": {"label": 1, "data": {"text": "This same dose of carvedilol also inhibited, but to a lesser degree, the beta 2 adrenoceptor mediated vasodepressor response to salbutamol in pithed rats whose blood pressure was elevated by a constant intravenous infusion of angiotensin II.", "entity1": "beta 2 adrenoceptor", "entity2": "salbutamol", "span1": [73, 92], "span2": [128, 138]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15561": {"label": 1, "data": {"text": "Taken together, our data demonstrate that puerarin attenuates MPTP-induced dopaminergic neuronal degeneration via modulating GDNF expression, PI3K/Akt pathway and GSH activation, which subsequently ameliorate MPTP-induced ROS formation and decrease of Lamp 2A expression.", "entity1": "PI3K", "entity2": "MPTP", "span1": [142, 146], "span2": [62, 66]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, 3, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5668": {"label": 2, "data": {"text": "Ibandronate increases the expression of the pro-apoptotic gene FAS by epigenetic mechanisms in tumor cells.", "entity1": "FAS", "entity2": "Ibandronate", "span1": [63, 66], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6526": {"label": 9, "data": {"text": "Almost all patients with SUR1 (38/41) or KIR6.2 (5/7) mutations were resistant to diazoxide.", "entity1": "KIR6.2", "entity2": "diazoxide", "span1": [41, 47], "span2": [82, 91]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6575": {"label": 7, "data": {"text": "The 2.0A crystal structure of the MalP/Glc1P binary complex shows that the Glc1P substrate adopts a conformation seen previously with both inactive and active forms of mammalian GP, with the phosphate group not in close contact with the 5'-phosphate group of the essential pyridoxal phosphate (PLP) cofactor.", "entity1": "MalP", "entity2": "pyridoxal phosphate", "span1": [34, 38], "span2": [273, 292]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 7, 8, -1, -1, -1, -1, 9]},
+	"1023": {"label": 2, "data": {"text": "Activation of endogenous somatostatin receptor subtype 2 (sst2) by somatostatin-14 or activation of transiently transfected rat D2 dopamine receptors (rD2(long)) by quinpirole had no effect.", "entity1": "somatostatin receptor subtype 2", "entity2": "somatostatin-14", "span1": [25, 56], "span2": [67, 82]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5873": {"label": 1, "data": {"text": "Interestingly, amoxapine binds with a good affinity (IC50 = 0.30 microM) to 5-HT3 receptors labelled by [3H]zacopride in cortical membranes.", "entity1": "5-HT3", "entity2": "amoxapine", "span1": [76, 81], "span2": [15, 24]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4471": {"label": 3, "data": {"text": "Catalpol reduced the expression of pro-inflammatory mediates, such as monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-\u03b1 (TNF-\u03b1), inducible NO synthase (iNOS), and receptor for AGE (RAGE).", "entity1": "RAGE", "entity2": "Catalpol", "span1": [195, 199], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8833": {"label": 3, "data": {"text": "RESULTS: By Western blot analysis of spinal cord tissues, we have demonstrated that treatment with bioactive RS -GRA significantly decreased nuclear factor (NF)-kB translocation, pro-inflammatory cytokine production such as interleukin-1\u03b2 (IL-1\u03b2), and apoptosis (Bax and caspase 3 expression).", "entity1": "Bax", "entity2": "RS -GRA", "span1": [263, 266], "span2": [109, 116]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"14677": {"label": 9, "data": {"text": "In contrast, GSK1292263 did not inhibit OATP1B1 based on the lack of changes in simvastatin acid exposure [mean AUC(0-inf) ratio (90% CI) of 1.05 (0.91, 1.21)].", "entity1": "OATP1B1", "entity2": "GSK1292263", "span1": [40, 47], "span2": [13, 23]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"12569": {"label": 9, "data": {"text": "Glutathione-independent prostaglandin D synthase [prostaglandin-H2 D-isomerase; (5Z,13E)-(15S)-9 alpha,11 alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase, EC 5.3.99.2] is an enzyme responsible for biosynthesis of prostaglandin D2 in the central nervous system.", "entity1": "EC 5.3.99.2", "entity2": "Glutathione", "span1": [165, 176], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12442": {"label": 6, "data": {"text": "An HTS campaign identified several weak M5 PAMs (M5 EC50 >10\u03bcM) with a structurally related isatin core that possessed a southern phenethyl ether linkage.", "entity1": "M5", "entity2": "isatin", "span1": [49, 51], "span2": [92, 98]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8049": {"label": 2, "data": {"text": "In this current study, paclitaxel was found to increase phosphorylation of mitogen-activated protein kinase (MAPK) kinase 3/6 (MKK3/6)-p38 MAPK as well as protein and mRNA levels of ERCC1 in H1650 and H1703 cells.", "entity1": "mitogen-activated protein kinase", "entity2": "paclitaxel", "span1": [75, 107], "span2": [23, 33]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1980": {"label": 1, "data": {"text": "The narrow substrate specificity prevents interaction of drugs with dicarboxylate-like structure with hNaDC-3 and ensures sufficient support of the proximal tubule cells with alpha-ketoglutarate for anion secretion via organic anion transporter 1 or 3.", "entity1": "organic anion transporter 1 or 3", "entity2": "alpha-ketoglutarate", "span1": [219, 251], "span2": [175, 194]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, 8, -1, -1, -1, -1]},
+	"15867": {"label": 1, "data": {"text": "Immunoblot studies showed that K(+)-depolarization increased CaMKII\u03b1 phosphorylation in a KN-62 sensitive manner and promoted CaMKII\u03b1 binding to D3 receptors.", "entity1": "CaMKII\u03b1", "entity2": "KN-62", "span1": [126, 133], "span2": [90, 95]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6861": {"label": 5, "data": {"text": "To test this, we studied the possible effect of the endothelin receptor antagonist, bosentan (50 and 100 mg kg(-1)) on serum glucose and insulin levels as well as on liver glycogen contents in normoglycemic stressed animals.", "entity1": "endothelin receptor", "entity2": "bosentan", "span1": [52, 71], "span2": [84, 92]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11930": {"label": 1, "data": {"text": "To evaluate whether fisetin regulates mTORC1 signaling, we investigated the phosphorylation and kinase activity of the 70-kDa ribosomal protein S6 kinase 1 (S6K1) and mTORC1 in 3T3-L1 preadipocytes.", "entity1": "kinase", "entity2": "fisetin", "span1": [96, 102], "span2": [20, 27]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11222": {"label": 1, "data": {"text": "The insulin responses to glucose, mitiglinide, tolbutamide, and glibenclamide in MIN6 cells after chronic mitiglinide, nateglinide, or repaglinide treatment were comparable to those after chronic tolbutamide and glibenclamide treatment.", "entity1": "insulin", "entity2": "tolbutamide", "span1": [4, 11], "span2": [196, 207]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12218": {"label": 1, "data": {"text": "This mechanism involves the calcium-dependent tyrosine kinase Pyk2, the non-receptor tyrosine kinase c-Src and the focal adhesion protein/steroid receptor co-factor, Hic-5.", "entity1": "focal adhesion protein", "entity2": "calcium", "span1": [115, 137], "span2": [28, 35]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10987": {"label": 4, "data": {"text": "Preincubation with 1 microM of the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) caused a small but significant decrease in isoprenaline-induced E(max), indicating activated PKC-mediated heterologous beta(2)-adrenoceptor desensitization.", "entity1": "beta(2)-adrenoceptor", "entity2": "isoprenaline", "span1": [225, 245], "span2": [149, 161]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10837": {"label": 3, "data": {"text": "Imatinib (STI571, Gleevec, Glivec; Novartis Pharmaceuticals, East Hanover, NJ), a selective inhibitor of KIT, ABL, BCR-ABL, PDGFRA, and PDGFRB, represents a new paradigm of targeted cancer therapy and has revolutionized the treatment of patients with chronic myelogenous leukemia and GISTs.", "entity1": "PDGFRB,", "entity2": "Imatinib", "span1": [136, 143], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14326": {"label": 3, "data": {"text": "Additionally, DMF and Ad-Nrf2 repressed TGF-beta-stimulated Smad3 activity by inhibiting Smad3 phosphorylation, which was restored by siRNA-mediated knockdown of Nrf2 expression.", "entity1": "TGF-beta", "entity2": "DMF", "span1": [40, 48], "span2": [14, 17]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3572": {"label": 2, "data": {"text": "Although the treatment with MSG increased IRS-1 tyrosine phosphorylation (pIRS-1) by 96\u00a0% (MSG, 17.02\u00a0\u00b1\u00a00.6; control, 8.7\u00a0\u00b1\u00a00.2\u00a0a.u.", "entity1": "pIRS-1", "entity2": "MSG", "span1": [74, 80], "span2": [91, 94]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11728": {"label": 8, "data": {"text": "The mitochondrial respiratory chain complex IV (cytochrome c oxidase) is a multi-subunit enzyme that transfers electrons from cytochrome c to molecular oxygen, yielding water.", "entity1": "cytochrome c oxidase", "entity2": "oxygen", "span1": [48, 68], "span2": [152, 158]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1308": {"label": 3, "data": {"text": "It was also antagonized by the non-specific cyclooxygenase (COX) inhibitor, indomethacin, and by the selective COX-2 inhibitor, NS-398, but not by the specific COX-1 inhibitor, valeryl salicylate.", "entity1": "COX-2", "entity2": "NS-398", "span1": [111, 116], "span2": [128, 134]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"9688": {"label": 1, "data": {"text": "Ziprasidone is a novel antipsychotic agent which binds with high affinity to 5-HT1A receptors (Ki = 3.4 nM), in addition to 5-HT1D, 5-HT2, and D2 sites.", "entity1": "D2", "entity2": "Ziprasidone", "span1": [143, 145], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13504": {"label": 3, "data": {"text": "In this study the neuromuscular blocking drug vecuronium and the controls gallamine and pancuronium slowed the rate of atropine induced [(3)H]N-methylscopolamine dissociation from Chinese hamster ovary cells expressing recombinant human muscarinic M2 receptors K(off) values min(-1); vecuronium (125 nM), atropine 0.45+/-0.07+blocker 0.04+/-0.02; gallamine (21 nM), atropine 0.42+/-0.05+blocker 0.15+/-0.04; pancuronium(21 nM), atropine 0.36+/-0.03+blocker 0.03+/-0.01).", "entity1": "human muscarinic M2 receptors", "entity2": "pancuronium", "span1": [231, 260], "span2": [88, 99]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12365": {"label": 1, "data": {"text": "These results suggest that ganglioside-bound A\u03b2 (GA\u03b2), which acts as an endogenous seed for A\u03b2 fibril formation in AD brains, is generated on ASIGN on synaptosomal membranes.", "entity1": "A\u03b2", "entity2": "ganglioside", "span1": [45, 47], "span2": [27, 38]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11362": {"label": 1, "data": {"text": "CONCLUSIONS: These data affirm that ziprasidone is similar to other novel antipsychotics in having greater 5-HT(2) than D(2) receptor occupancy at therapeutic doses and suggest that the optimal effective dose of ziprasidone is closer to 120 mg/day than to the lower doses suggested by previous PET studies.", "entity1": "5-HT(2)", "entity2": "ziprasidone", "span1": [107, 114], "span2": [36, 47]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5785": {"label": 9, "data": {"text": "A cDNA encoding the complete amino acid sequence of aminoacylase 1 (N-acylamino acid aminohydrolase, ACY-1) [EC 3.5.1.14], a dimeric metalloprotein having two Zn2+ in the molecule, which catalyzes the deacylation of N-acylated L-amino acids except L-aspartic acid, has been isolated from porcine kidney lambda gt10 cDNA library and sequenced.", "entity1": "ACY-1", "entity2": "L-aspartic acid", "span1": [101, 106], "span2": [248, 263]}, "weak_labels": [0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"4047": {"label": 3, "data": {"text": "The molecular mechanism studies suggested that neoechinulin A may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regulating kinase 1 (ASK-1) and nuclear translocation of nuclear factor-\u03baB (NF-\u03baB) p65 and p50 subunits.", "entity1": "p50", "entity2": "neoechinulin A", "span1": [257, 260], "span2": [47, 61]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11939": {"label": 3, "data": {"text": "We also observed that fisetin efficiently suppressed the phosphorylation of Akt, S6K1 and mTORC1 in adipose tissue.", "entity1": "Akt", "entity2": "fisetin", "span1": [76, 79], "span2": [22, 29]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9054": {"label": 1, "data": {"text": "Levomepromazine was the most potent and fluphenazine the least potent of the four drugs in histamine H1 receptor binding.", "entity1": "histamine H1 receptor", "entity2": "Levomepromazine", "span1": [91, 112], "span2": [0, 15]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5065": {"label": 3, "data": {"text": "These data provided a novel insight to the mechanisms of Rg1protective effects on A\u03b225-35-induced endothelial cells apoptosis, suggesting that GR-ERK signaling pathway might play an important role in it.", "entity1": "A\u03b225-35", "entity2": "Rg1", "span1": [82, 89], "span2": [57, 60]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11372": {"label": 1, "data": {"text": "Here, we report the initial characterization of I3A as a protein kinase C (PKC) ligand.", "entity1": "protein kinase C", "entity2": "I3A", "span1": [57, 73], "span2": [48, 51]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14224": {"label": 4, "data": {"text": "Adult ovariectomised rats were divided into six groups and injected either with vehicle or a single dose of oestradiol, a selective ER\u03b1 agonist-PPT [4,4',4\u2033-(4-propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol], a selective ER\u03b2 agonist-DPN [2,3-bis(4-hydroxyphenyl)-propionitrile], a selective ER\u03b1 antagonist-MPP [1,3-bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride] or a selective ER\u03b2 antagonist-PHTPP (4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol).", "entity1": "ER\u03b1", "entity2": "PPT", "span1": [132, 135], "span2": [144, 147]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13105": {"label": 1, "data": {"text": "There is a growing appreciation that the cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) signaling pathway is organized to form transduction units that function to deliver specific messages.", "entity1": "protein kinase A", "entity2": "cyclic adenosine monophosphate", "span1": [79, 95], "span2": [41, 71]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11170": {"label": 1, "data": {"text": "Thus, our studies provide new insight into the regulation of TH by the concentration of H4biopterin which may have significant implications for the physiological regulation of catecholamine biosynthesis in neuroendocrine cells.", "entity1": "TH", "entity2": "H4biopterin", "span1": [61, 63], "span2": [88, 99]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8762": {"label": 8, "data": {"text": "In conclusion, this study expands the understanding of the substrate specificity of UGT2B10, highlighting its preference for tertiary amines with higher affinities and clearance values than those of UGT1A4 and UGT1A3.", "entity1": "UGT1A4", "entity2": "tertiary amines", "span1": [199, 205], "span2": [125, 140]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"15348": {"label": 3, "data": {"text": "Coumarin 7-hydroxylation, catalyzed by P450 2A13, was strongly inhibited by 2'-methoxy-5,7-dihydroxyflavone, 2-ethynylnaphthalene, 2'-methoxyflavone, 2-naphththalene propargyl ether, acenaphthene, acenaphthylene, naphthalene, 1-acetylpyrene, flavanone, chrysin, 3-ethynylphenanthrene, flavone, and 7-hydroxyflavone; these chemicals induced Type I spectral changes with low Ks values.", "entity1": "P450 2A13", "entity2": "flavone", "span1": [39, 48], "span2": [285, 292]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"3080": {"label": 3, "data": {"text": "Only PLZ inhibited MAO and ALA-T and elevated ALA levels.", "entity1": "MAO", "entity2": "PLZ", "span1": [19, 22], "span2": [5, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6003": {"label": 8, "data": {"text": "To explain our observations, we propose that hNETs function as ion-gated ligand channels with an indefinite stoichiometry relating ion flux to NE transport.", "entity1": "hNETs", "entity2": "NE", "span1": [45, 50], "span2": [143, 145]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"3286": {"label": 1, "data": {"text": "Prednisolone fast feedback was only reduced by glucocorticoid receptor antagonist pretreatment and not by mineralocorticoid receptor antagonism, suggesting a glucocorticoid receptor-mediated pathway.", "entity1": "glucocorticoid receptor", "entity2": "Prednisolone", "span1": [47, 70], "span2": [0, 12]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"13231": {"label": 1, "data": {"text": "Glutamate stimulates glutamate receptor interacting protein 1 degradation by ubiquitin-proteasome system to regulate surface expression of GluR2.", "entity1": "ubiquitin", "entity2": "Glutamate", "span1": [77, 86], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14828": {"label": 3, "data": {"text": "FXa inhibitors, e.g. rivaroxaban and apixaban, are potent, oral direct inhibitors of prothrombinase-bound, clot-associated or free FXa.", "entity1": "FXa", "entity2": "apixaban", "span1": [0, 3], "span2": [37, 45]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10891": {"label": 1, "data": {"text": "Structural analysis revealed that these three roscovitines bind similarly in the pyridoxal-binding site of PDXK rather than in the anticipated ATP-binding site.", "entity1": "PDXK", "entity2": "roscovitines", "span1": [107, 111], "span2": [46, 58]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7050": {"label": 3, "data": {"text": "CONCLUSIONS: Imatinib inhibits RET-mediated MTC cell growth affecting RET protein levels in vitro in a dose-dependent manner.", "entity1": "RET", "entity2": "Imatinib", "span1": [31, 34], "span2": [13, 21]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3103": {"label": 3, "data": {"text": "Acarbose, an alpha-glucosidase inhibitor, delays the absorption of carbohydrate from the small intestine, thereby reducing postprandial hyperglycemia.", "entity1": "alpha-glucosidase", "entity2": "Acarbose", "span1": [13, 30], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1601": {"label": 3, "data": {"text": "Nevertheless, coperfusion with 0.1 and 0.3 mM 5-nitro-2-(3-phenylpropylamino) benzoic acid, which inhibits the cystic fibrosis transmembrane conductor regulator (CFTR), dose dependently inhibited S3226-induced DBS.", "entity1": "CFTR", "entity2": "5-nitro-2-(3-phenylpropylamino) benzoic acid", "span1": [162, 166], "span2": [46, 90]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2822": {"label": 3, "data": {"text": "Dexamethasone (DXM) decreased the expression of CXCL-8, VEGF, and iNOS induced by reIL-4, while 1400W dihydrochloride (1400W), a selective inhibitor of iNOS, decreased the expression of E-selectin, VEGF, and iNOS.", "entity1": "VEGF", "entity2": "DXM", "span1": [56, 60], "span2": [15, 18]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1444": {"label": 1, "data": {"text": "We investigated the mechanism of action of atomoxetine in ADHD by evaluating the interaction of atomoxetine with monoamine transporters, the effects on extracellular levels of monoamines, and the expression of the neuronal activity marker Fos in brain regions.", "entity1": "Fos", "entity2": "atomoxetine", "span1": [239, 242], "span2": [96, 107]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"5299": {"label": 1, "data": {"text": "In addition, prunetin inhibits NF-\u03baB-dependent inflammatory responses by modulating I\u03baB kinase (IKK)-inhibitor \u03baB\u03b1 (I\u03baB\u03b1)-NF-\u03baB signaling.", "entity1": "IKK", "entity2": "prunetin", "span1": [96, 99], "span2": [13, 21]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15488": {"label": 0, "data": {"text": "We used whole-cell recordings of human embryonic kidney cells heterologously expressing either wild-type TRPA1 or TRPA1 with three serine-substituted cysteines crucial for electrophile activation (C621S, C641S, C665S).", "entity1": "TRPA1", "entity2": "serine", "span1": [114, 119], "span2": [131, 137]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11745": {"label": 0, "data": {"text": "The Ves a 1 structure, which is composed of seven \u03b1-helixes and eleven \u03b2-strands, contains the \u03b2-strand/\u025bSer/\u03b1-helix structural motif, which contains the Gly-X-Ser-X-Gly consensus sequence.", "entity1": "Ves a 1", "entity2": "Ser", "span1": [4, 11], "span2": [160, 163]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14889": {"label": 2, "data": {"text": "Induction of HO-1 through p38 MAPK/Nrf2 signaling pathway by ethanol extract of Inula helenium L. reduces inflammation in LPS-activated RAW 264.7 cells and CLP-induced septic mice.", "entity1": "MAPK", "entity2": "ethanol", "span1": [30, 34], "span2": [61, 68]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13104": {"label": 4, "data": {"text": "Our work shows that sulfonylureas and glinides additionally bind to PPARgamma and exhibit PPARgamma agonistic activity.", "entity1": "PPARgamma", "entity2": "glinides", "span1": [90, 99], "span2": [38, 46]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10429": {"label": 1, "data": {"text": "Tazarotene is an acetylenic retinoid which is metabolised to tazarotenic acid and which binds selectively to the retinoid receptors RARbeta and RARgamma.", "entity1": "RARgamma", "entity2": "acetylenic retinoid", "span1": [144, 152], "span2": [17, 36]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1650": {"label": 5, "data": {"text": "The 5-HT(1/2/5/7)-receptor antagonist methysergide and the 5-HT(2A/2B/2C)-receptor antagonist LY 53857 enhanced clomipramine-induced hyperglycemia, while the 5-HT(1A/1B)-receptor antagonist (-)-propranolol and the 5-HT(3/4)-receptor antagonist tropisetron did not affect it.", "entity1": "5-HT(3/4)-receptor", "entity2": "tropisetron", "span1": [214, 232], "span2": [244, 255]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"7957": {"label": 6, "data": {"text": "To investigate the role of mGluR8 in modulating the synaptic responses of retinal ganglion cells, we used a recently identified positive allosteric modulator of mGluR8, AZ12216052 (AZ) and the mGluR8-specific orthosteric agonist (S)-3,4-dicarboxyphenylglycine (DCPG).", "entity1": "mGluR8", "entity2": "AZ12216052", "span1": [161, 167], "span2": [169, 179]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, 6, 6, -1, -1, -1, -1, -1, -1, -1]},
+	"9206": {"label": 1, "data": {"text": "We have found that certain naphthalenesulfonamides [e.g., N-6(-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7)] and phenothiazines [e.g., trifluoperazine (TFP)] induce a loss of cell-surface receptors for alpha 2-macroglobulin, and epidermal growth factor (EGF) in fibroblasts.", "entity1": "EGF", "entity2": "W-7", "span1": [261, 264], "span2": [110, 113]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"2950": {"label": 0, "data": {"text": "Cocrystal structures of PDE5 catalytic (C) domain with inhibitors reveal a hydrogen bond and hydrophobic interactions with Tyr-612, hydrogen bonds with Gln-817, a hydrophobic clamp formed by Phe-820 and Val-782, and contacts with His-613, Leu-765, and Phe-786 [Sung et al.", "entity1": "PDE5 catalytic (C) domain", "entity2": "Tyr", "span1": [24, 49], "span2": [123, 126]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7354": {"label": 1, "data": {"text": "Immature (reticulated) platelets may modulate the antiplatelet effects of aspirin through uninhibited cyclooxygenase (COX)-1 and COX-2.", "entity1": "COX-2", "entity2": "aspirin", "span1": [129, 134], "span2": [74, 81]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5064": {"label": 3, "data": {"text": "Activating glucocorticoid receptor-ERK signaling pathway contributes to ginsenoside Rg1 protection against \u03b2-amyloid peptide-induced human endothelial cells apoptosis.", "entity1": "\u03b2-amyloid peptide", "entity2": "ginsenoside Rg1", "span1": [107, 124], "span2": [72, 87]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7894": {"label": 2, "data": {"text": "Data suggest that bisphosphonates via modulation of the activity of small-GTPases induce apoptosis in neoplastic cells by DNA-CpG-demethylation and stimulation of FAS-expression.", "entity1": "FAS", "entity2": "bisphosphonates", "span1": [163, 166], "span2": [18, 33]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4147": {"label": 3, "data": {"text": "Cotreatments of 5, 10 and 20 \u00b5g/mL concentrations of MEP with aflatoxin B(1) decreased the frequencies of SCE and the malondialdehyde level and increased amount of superoxide dismutase, glutathione and glutathione peroxidase which were decreased by aflatoxin.", "entity1": "glutathione peroxidase", "entity2": "aflatoxin", "span1": [202, 224], "span2": [249, 258]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15846": {"label": 2, "data": {"text": "The expression of ABCA1 and ABCG1 was induced by 24-OHC, as well as TO901317 and retinoic acid, which are ligands of the nuclear receptors LXR/RXR.", "entity1": "ABCA1", "entity2": "24-OHC", "span1": [18, 23], "span2": [49, 55]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12786": {"label": 1, "data": {"text": "Collectively, these data provide a mechanistic basis for the potency and in vitro selectivity of valdecoxib for COX-2.", "entity1": "COX-2", "entity2": "valdecoxib", "span1": [112, 117], "span2": [97, 107]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3171": {"label": 4, "data": {"text": "Terbutaline (Bricanyl) and its prodrug Bambuterol (Bambec) are highly potent beta(2)-adrenoceptor agonists often used in asthma patients.", "entity1": "beta(2)-adrenoceptor", "entity2": "Bambuterol", "span1": [77, 97], "span2": [39, 49]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7370": {"label": 2, "data": {"text": "Repeated cocaine resulted in CREB phosphorylation in all analyzed subregions of the NAc excluding the most ventrolateral region of the shell 2 weeks after cessation of repeated cocaine, but rats challenged after 2 drug-free days yielded a more localized activation of CREB in the 3 most dorsomedial zones of the shell.", "entity1": "CREB", "entity2": "cocaine", "span1": [268, 272], "span2": [177, 184]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15331": {"label": 1, "data": {"text": "In addition, benzo[c]phenanthrene, fluoranthene, 2,3-dihydroxy-2,3-dihydrofluoranthene, pyrene, 1-hydroxypyrene, 1-nitropyrene, 1-acetylpyrene, 2-acetylpyrene, 2,5,2',5'-tetrachlorobiphenyl, 7-hydroxyflavone, chrysin, and galangin were found to induce a Type I spectral change only with P450 2A13.", "entity1": "P450 2A13", "entity2": "2-acetylpyrene", "span1": [287, 296], "span2": [144, 158]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10223": {"label": 8, "data": {"text": "AMP-activated protein kinase (AMPK) activity increases in response to depletion of cellular energy stores, and this enzyme has been implicated in the stimulation of glucose uptake into skeletal muscle and the inhibition of liver gluconeogenesis.", "entity1": "AMPK", "entity2": "glucose", "span1": [30, 34], "span2": [165, 172]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"687": {"label": 3, "data": {"text": "We topically applied the nitric oxide synthase (NOS) inhibitor, NG-nitro-L-arginine, on sciatic nerve and observed reduced inhibition of NBF in EDN, which was correctable with a cilazapril diet.", "entity1": "NOS", "entity2": "NG-nitro-L-arginine", "span1": [48, 51], "span2": [64, 83]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12499": {"label": 3, "data": {"text": "In H2O2-treated cells, calycopterin also suppressed cytochrome C release to cytosol that is necessary for maintaining mitochondrial homeostasis in survived cells.", "entity1": "cytochrome C", "entity2": "calycopterin", "span1": [52, 64], "span2": [23, 35]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5094": {"label": 2, "data": {"text": "Aldosterone also induces the rapid phosphorylation of Protein Kinase D1 (PKD1).", "entity1": "Protein Kinase D1", "entity2": "Aldosterone", "span1": [54, 71], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5961": {"label": 3, "data": {"text": "After loperamide administration ACTH levels fell to a nadir of 135 +/- 76 pg/ml, and then CRH was still able to induce an ACTH increase; the pattern of ACTH response to CRH was slightly delayed.", "entity1": "ACTH", "entity2": "loperamide", "span1": [32, 36], "span2": [6, 16]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6057": {"label": 3, "data": {"text": "Both NE and phorbol esters increased the rate of alpha-AR mRNA degradation.", "entity1": "alpha-AR", "entity2": "NE", "span1": [49, 57], "span2": [5, 7]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1481": {"label": 8, "data": {"text": "Mouse brain serine racemase catalyzes specific elimination of L-serine to pyruvate.", "entity1": "Mouse brain serine racemase", "entity2": "L-serine", "span1": [0, 27], "span2": [62, 70]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"3078": {"label": 3, "data": {"text": "RESULTS: Both PLZ and VIG inhibited GABA-T and elevated GABA levels.", "entity1": "GABA-T", "entity2": "PLZ", "span1": [36, 42], "span2": [14, 17]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13142": {"label": 2, "data": {"text": "This mRNA level elevation was not prevented by pretreatment with actinomycin D. When the PTB-binding site in insulin 1 mRNA was incubated with the islet cytosolic fraction, the RNA-protein complex level was increased in the cytosolic fraction obtained from GalN-treated rats compared to the level in control rats.", "entity1": "insulin 1", "entity2": "GalN", "span1": [109, 118], "span2": [257, 261]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"12801": {"label": 1, "data": {"text": "STI 571 (imatinib mesylate [Gleevec]) might be an effective therapy in this case, since Gleevec targets both PDGFRA and c-kit oncoproteins.", "entity1": "PDGFRA", "entity2": "imatinib mesylate", "span1": [109, 115], "span2": [9, 26]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9895": {"label": 5, "data": {"text": "UNLABELLED: Apparent muscarinic acetylcholine (mAch) receptor occupancy in mouse cerebral cortex, hippocampus, and striatum by scopolamine, an antagonist, and biperiden, a relatively selective M1 antagonist, was estimated with competitive binding studies using two different radioligands: 3H-N-methyl piperidyl benzilate (3H-NMPB) and 3H-quinuclidinyl benzilate (3H-QNB).", "entity1": "M1", "entity2": "biperiden", "span1": [193, 195], "span2": [159, 168]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4134": {"label": 2, "data": {"text": "KCNK1, a member of the family of two-pore K(+) ion channels, is specifically induced in the livers of male mice after phenobarbital treatment.", "entity1": "K(+) ion channels", "entity2": "phenobarbital", "span1": [42, 59], "span2": [118, 131]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15780": {"label": 3, "data": {"text": "Aminopropylindenes derived from Grundmann's ketone as a novel chemotype of oxidosqualene cyclase inhibitors.", "entity1": "oxidosqualene cyclase", "entity2": "Aminopropylindenes", "span1": [75, 96], "span2": [0, 18]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1528": {"label": 0, "data": {"text": "Expression in yeast allowed kinetic characterization of the two native enzymes, and of a chimaera in which the distinctive N-terminal segment of ovine M-CPT 1 was replaced with that from rat M-CPT 1.", "entity1": "ovine M-CPT 1", "entity2": "N", "span1": [145, 158], "span2": [123, 124]}, "weak_labels": [-1, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11634": {"label": 1, "data": {"text": "In addition, the molecular configuration of vardenafil differs from that of sildenafil when bound to PDE5.", "entity1": "PDE5", "entity2": "sildenafil", "span1": [101, 105], "span2": [76, 86]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11363": {"label": 1, "data": {"text": "CONCLUSIONS: These data affirm that ziprasidone is similar to other novel antipsychotics in having greater 5-HT(2) than D(2) receptor occupancy at therapeutic doses and suggest that the optimal effective dose of ziprasidone is closer to 120 mg/day than to the lower doses suggested by previous PET studies.", "entity1": "D(2) receptor", "entity2": "ziprasidone", "span1": [120, 133], "span2": [36, 47]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15564": {"label": 2, "data": {"text": "Puerarin administration enhanced glutathione (GSH) activity, glial cell line-derived neurotrophic factor (GDNF) expression and PI3K/Akt pathway activation, which might ameliorate MPTP injection-induced progressive elevation of reactive oxygen species (ROS) formation in mice.", "entity1": "Akt", "entity2": "Puerarin", "span1": [132, 135], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14819": {"label": 5, "data": {"text": "Results indicate that AM4054 serves as an effective CB(1) discriminative stimulus, with an onset and time course of action comparable with that of the CB(1) agonist \u0394(9)-tetrahydrocannabinol, and that the inverse agonist rimonabant and the neutral antagonist AM4113 produce dose-related rightward shifts in the AM4054 dose-effect curve, indicating that both drugs surmountably antagonize the discriminative stimulus effects of AM4054.", "entity1": "CB(1)", "entity2": "AM4113", "span1": [151, 156], "span2": [259, 265]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, 5, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"6733": {"label": 3, "data": {"text": "Compounds of several other structural families, including the quinoxaline AG1296, the bis(1H-2-indolyl)-1-methanone D-65476, the indolinones SU5416 and SU11248, the indolocarbazoles PKC412 and CEP-701, and the piperazonyl quinazoline CT53518, are potent inhibitors of Flt3 kinase.", "entity1": "kinase", "entity2": "indolocarbazoles", "span1": [273, 279], "span2": [165, 181]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6873": {"label": 2, "data": {"text": "placebo; n=24 animals in each group]; 2) neutrophil sequestration in the pancreas [pancreatic myeloperoxidase oxidase (MPO) activity (fold increase over control) (prophylactic treatment: placebo, 5.78+/-0.63; PAG, 2.97+/-0.39; therapeutic treatment: placebo, 5.48+/-0.52; PAG, 3.03+/-0.47; P<0.05 PAG c.f.", "entity1": "MPO", "entity2": "PAG", "span1": [119, 122], "span2": [209, 212]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15077": {"label": 1, "data": {"text": "Although not a \u03b2-lactam, the chemical structure of avibactam closely resembles portions of the cephem bicyclic ring system, and avibactam has been shown to bond covalently to \u03b2-lactamases.", "entity1": "\u03b2-lactamases", "entity2": "avibactam", "span1": [175, 187], "span2": [128, 137]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"2286": {"label": 3, "data": {"text": "Also consistent with the involvement of Gq coupled EP1 receptors, the PGE1 stimulation is inhibited by the PKCI vector (encoding the PKC inhibitory domain), the PKC inhibitor Go 6976, thapsigargin, as well as the calmodulin antagonists W7 and W13.", "entity1": "PKC", "entity2": "Go 6976", "span1": [161, 164], "span2": [175, 182]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9438": {"label": 3, "data": {"text": "PTP inhibition by hisphosphonates or vanadate was diminished by the metal chelating agent EDTA, or by the reducing agent dithiothreitol, suggesting that a metal ion and the oxidation of a cysteine residue are required for full inhibition.", "entity1": "PTP", "entity2": "vanadate", "span1": [0, 3], "span2": [37, 45]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2467": {"label": 9, "data": {"text": "Liver choline dehydrogenase and kidney betaine-homocysteine methyltransferase expression are not affected by methionine or choline intake in growing rats.", "entity1": "choline dehydrogenase", "entity2": "methionine", "span1": [6, 27], "span2": [109, 119]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"6952": {"label": 1, "data": {"text": "[3H]-maraviroc bound with high affinity to CCR5 from macaque (K(d) = 1.36+/-0.07 nM) and human (K(d) = 0.86 +/- 0.08 nM), but was found to dissociate approximately 10-fold more quickly from macaque CCR5.", "entity1": "CCR5", "entity2": "[3H]-maraviroc", "span1": [43, 47], "span2": [0, 14]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13110": {"label": 8, "data": {"text": "By using pharmacological and genetic manipulation of phosphodiesterases (PDEs), we demonstrate that compartmentalized PDE4B and PDE4D are responsible for selectively modulating the concentration of cAMP in individual subcellular compartments.", "entity1": "PDE4B", "entity2": "cAMP", "span1": [118, 123], "span2": [198, 202]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8054": {"label": 2, "data": {"text": "In this current study, paclitaxel was found to increase phosphorylation of mitogen-activated protein kinase (MAPK) kinase 3/6 (MKK3/6)-p38 MAPK as well as protein and mRNA levels of ERCC1 in H1650 and H1703 cells.", "entity1": "ERCC1", "entity2": "paclitaxel", "span1": [182, 187], "span2": [23, 33]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1502": {"label": 2, "data": {"text": "db/db mice treated with DRF 2655 showed 5- and 3.6-fold inhibition in phosphoenolpyruvate carboxykinase and glucose 6-phosphatase activity and 651% and 77% increases in the beta-oxidation enzymes carnitine palmitoyltransferase and carnitine acetyltransferase, respectively.", "entity1": "carnitine acetyltransferase", "entity2": "DRF 2655", "span1": [231, 258], "span2": [24, 32]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9354": {"label": 0, "data": {"text": "Single-strand conformational analysis and nucleotide sequencing of the entire coding region of the PC3 gene in 102 Japanese subjects with NIDDM revealed missense mutations in exons 2 (Arg/Gln53) and 14 (Gln/Glu638), neither of which was associated with NIDDM in this population.", "entity1": "Gln/Glu638", "entity2": "nucleotide", "span1": [203, 213], "span2": [42, 52]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3879": {"label": 3, "data": {"text": "Furthermore, we validated the inhibition of GSK-3\u03b2/NF-\u03baB signaling following cinobufagin treatment.", "entity1": "NF-\u03baB", "entity2": "cinobufagin", "span1": [51, 56], "span2": [77, 88]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"332": {"label": 3, "data": {"text": "The refolding kinetics of guanidine-denatured disulfide-intact bovine pancreatic ribonuclease A (RNase A) and its proline-42-to-alanine mutant (Pro42Ala) have been studied by monitoring tyrosine burial and 2'-cytidine monophosphate (2'CMP) inhibitor binding.", "entity1": "Pro42Ala", "entity2": "2'-cytidine monophosphate", "span1": [144, 152], "span2": [206, 231]}, "weak_labels": [-1, -1, 0, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3012": {"label": 5, "data": {"text": "The ARB eprosartan is a nonbiphenyl nontetrazole angiotensin II type 1 receptor (AT1) antagonist, which acts to decrease total peripheral resistance.", "entity1": "angiotensin II type 1 receptor", "entity2": "eprosartan", "span1": [49, 79], "span2": [8, 18]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14525": {"label": 3, "data": {"text": "In contrast, EGCG markedly downregulated major bile acid transporters (Asbt and Ost\u03b1) and regulatory molecules (Shp and Fgf15) in the ileum.", "entity1": "bile acid transporters", "entity2": "EGCG", "span1": [47, 69], "span2": [13, 17]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"14144": {"label": 1, "data": {"text": "Mianserin and mirtazapine increased ERK1/2 phosphorylation in CHO cells expressing kappa-opioid receptors and C6 cells, and these effects were antagonized by nor-BNI.", "entity1": "kappa-opioid receptors", "entity2": "nor-BNI", "span1": [83, 105], "span2": [158, 165]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11855": {"label": 8, "data": {"text": "The calcium homeostasis proteins sarcoendoplasmic reticulum ATPase 2a (SERCA2a), sodium calcium exchanger-1, phospholamban (PLB), phospho-PLB, and calsequestrin 2 are important for contraction and relaxation.", "entity1": "calsequestrin 2", "entity2": "calcium", "span1": [147, 162], "span2": [4, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5303": {"label": 3, "data": {"text": "Promoter assay revealed that prunetin inhibits LPS-induced nitric oxide and prostaglandin E2 production through the suppression of iNOS and COX-2 at the transcriptional level.", "entity1": "iNOS", "entity2": "prunetin", "span1": [131, 135], "span2": [29, 37]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"9237": {"label": 3, "data": {"text": "Triclosan inhibited both cyclooxygenase 1 and cyclo-oxygenase 2 with IC-50 values of 43 microM and 227 microM, respectively.", "entity1": "cyclo-oxygenase 2", "entity2": "Triclosan", "span1": [46, 63], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10888": {"label": 1, "data": {"text": "To understand this interaction, we determined the crystal structure of PDXK in complex with (R)-roscovitine, N6-methyl-(R)-roscovitine, and O6-(R)-roscovitine, the two latter derivatives being designed to bind to PDXK but not to CDKs.", "entity1": "PDXK", "entity2": "N6-methyl-(R)-roscovitine", "span1": [213, 217], "span2": [109, 134]}, "weak_labels": [-1, -1, -1, 1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"15489": {"label": 0, "data": {"text": "We used whole-cell recordings of human embryonic kidney cells heterologously expressing either wild-type TRPA1 or TRPA1 with three serine-substituted cysteines crucial for electrophile activation (C621S, C641S, C665S).", "entity1": "C621S", "entity2": "serine", "span1": [197, 202], "span2": [131, 137]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8611": {"label": 2, "data": {"text": "Oxysterol-dependent NOX1 activation, as well as interleukin synthesis, were completely prevented by Cannonau red wine extract that contains an abundant phenolic fraction, in particular phenolic acids and flavonoids.", "entity1": "NOX1", "entity2": "Oxysterol", "span1": [20, 24], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6983": {"label": 1, "data": {"text": "With regard to hemodynamics, dobutamine caused larger heart rate and contractility increases and diastolic blood pressure decreases in Arg389- versus Gly389-beta1AR subjects.", "entity1": "beta1AR", "entity2": "dobutamine", "span1": [157, 164], "span2": [29, 39]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13558": {"label": 3, "data": {"text": "Using this assay, we found that both superoxide and nitric oxide inhibit renal cortical DDAH activity in vitro.", "entity1": "DDAH", "entity2": "nitric oxide", "span1": [88, 92], "span2": [52, 64]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"325": {"label": 1, "data": {"text": "The folding rate monitored by 2'CMP binding to the major slow-folding species of Pro42Ala RNase A is faster than the folding rate monitored by tyrosine burial; however, the folding rate monitored by inhibitor binding to the minor slow-folding species is decreased significantly over the folding rate monitored by tyrosine burial, indicating that the major and minor slow-folding species of Pro42Ala fold to the native state with different transition-state conformations in the rate-determining step.", "entity1": "RNase A", "entity2": "tyrosine", "span1": [90, 97], "span2": [143, 151]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7870": {"label": 5, "data": {"text": "Neuroprotection was attenuated by pertussis toxin, and inhibited by the selective type-1 S1PR (S1P1R) antagonist, W146, and by inhibitors of the mitogen associated protein kinase (MAPK) and the phosphatidylinositol-3-kinase (PtdIns-3-K) pathways.", "entity1": "S1P1R", "entity2": "W146", "span1": [95, 100], "span2": [114, 118]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8805": {"label": 8, "data": {"text": "Rates of benzydamine N-oxygenation (catalyzed by FMO3) varied (approximately 20-fold) among the 28 cynomolgus livers and were significantly correlated with FMO3 protein expression, indicating that the inter-animal variations in benzydamine N-oxygenation might be partly accounted for by the variable FMO3 expression.", "entity1": "FMO3", "entity2": "N", "span1": [49, 53], "span2": [21, 22]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"9464": {"label": 1, "data": {"text": "7. 8-Epi-PGF2 alpha showed only weak binding to the IP, TP, FP, EP2 and EP3 receptor at 10 microM concentration.", "entity1": "FP", "entity2": "7. 8-Epi-PGF2", "span1": [60, 62], "span2": [0, 13]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2853": {"label": 2, "data": {"text": "RORalpha ectopic expression activated the cAspAT gene transcription in absence of rosiglitazone, and its protein amount in nuclear extracts is 1.8-fold increased by rosiglitazone treatment of adipocytes.", "entity1": "RORalpha", "entity2": "rosiglitazone", "span1": [0, 8], "span2": [165, 178]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"298": {"label": 3, "data": {"text": "In catalytic properties, mouse CA V is closest to CA I; however, in inhibition by acetazolamide, ethoxzolamide, and cyanate, CA V is very similar to CA II.", "entity1": "CA II", "entity2": "cyanate", "span1": [149, 154], "span2": [116, 123]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5246": {"label": 2, "data": {"text": "Fluoride treatment also increased phosphorylation of JNK and ERK, but not p38, and apoptosis induced by fluoride was notably or partly suppressed by treatment with JNK or ERK inhibitors, respectively.", "entity1": "JNK", "entity2": "Fluoride", "span1": [53, 56], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"7829": {"label": 4, "data": {"text": "Cellular release of AChE by SH-SY5Y is significantly enhanced by the muscarinic acetylcholine receptor (mAChR) agonists carbachol or muscarine, with the effect of carbachol blocked by the mAChR antagonist atropine.", "entity1": "muscarinic acetylcholine receptor", "entity2": "muscarine", "span1": [69, 102], "span2": [133, 142]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5359": {"label": 1, "data": {"text": "We observed a significant reduction in CSE induced luciferase expression, NF-\u03baB DNA binding, I-\u03baB\u03b5 degradation and c-Rel nuclear translocation in cells pretreated with vitamin C.", "entity1": "c-Rel", "entity2": "vitamin C", "span1": [115, 120], "span2": [168, 177]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2041": {"label": 8, "data": {"text": "L-serine dehydratase (SDH), a member of the beta-family of pyridoxal phosphate-dependent (PLP) enzymes, catalyzes the deamination of L-serine and L-threonine to yield pyruvate or 2-oxobutyrate.", "entity1": "L-serine dehydratase", "entity2": "L-threonine", "span1": [0, 20], "span2": [146, 157]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"4578": {"label": 2, "data": {"text": "Taken together, these findings indicate that antofine induces Cx43 gap junction disassembly by the PKC\u03b2 signaling pathway.", "entity1": "PKC\u03b2", "entity2": "antofine", "span1": [99, 103], "span2": [45, 53]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11532": {"label": 1, "data": {"text": "Therefore, if these results are confirmed, D2 receptor occupancy at the beginning of treatment with risperidone may be a predictor of subsequent clinical response.", "entity1": "D2 receptor", "entity2": "risperidone", "span1": [43, 54], "span2": [100, 111]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6349": {"label": 5, "data": {"text": "Among the current AT1 receptor antagonists, the rank order of the relative binding affinities (highest affinity = 1) is: candesartan 1, telmisartan 10, E3174 (the active metabolite of losartan) 10, tasosartan 20, losartan 50, eprosartan 100 and the prodrug candesartan cilexetil 280.", "entity1": "AT1", "entity2": "telmisartan", "span1": [18, 21], "span2": [136, 147]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7162": {"label": 3, "data": {"text": "Decreased AT1R promoter activity with unchanged mRNA stability suggested that telmisartan suppressed AT1R gene expression at the transcriptional level.", "entity1": "AT1R", "entity2": "telmisartan", "span1": [101, 105], "span2": [78, 89]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14835": {"label": 1, "data": {"text": "Physiologic levels of Mg(2+) ions decrease ALDH1 activity in part by increasing NADH binding affinity to the enzyme.", "entity1": "ALDH1", "entity2": "NADH", "span1": [43, 48], "span2": [80, 84]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11952": {"label": 8, "data": {"text": "UGT1A6 exhibited a significantly higher Vmax and Km values toward both HFC and UDP-glucuronic acid than the other UGTs.", "entity1": "UGT1A6", "entity2": "HFC", "span1": [0, 6], "span2": [71, 74]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"986": {"label": 3, "data": {"text": "Moreover, BH(4) treatment of the fructose-fed rats markedly reduced the lipid peroxide content of both aortic and cardiac tissues and inhibited the activation of 2 redox-sensitive transcription factors, nuclear factor-kappaB and activating protein-1, which were increased in fructose-fed rats.", "entity1": "nuclear factor-kappaB", "entity2": "BH(4)", "span1": [203, 224], "span2": [10, 15]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4080": {"label": 3, "data": {"text": "Overall, higher alcohol production was reduced by ammonium supplementation, and this can be correlated with a general downregulation of genes encoding decarboxylases and dehydrogenases of the Ehrlich pathway.", "entity1": "dehydrogenases", "entity2": "ammonium", "span1": [170, 184], "span2": [50, 58]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"14092": {"label": 1, "data": {"text": "Lenalidomide and pomalidomide inhibited autoubiquitination of CRBN in HEK293T cells expressing thalidomide-binding competent wild-type CRBN, but not thalidomide-binding defective CRBN(YW/AA).", "entity1": "CRBN", "entity2": "thalidomide", "span1": [135, 139], "span2": [95, 106]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"7339": {"label": 8, "data": {"text": "Na+-Dependent transmembrane transport of small neutral amino acids, such as glutamine and alanine, is mediated, among others, by the neutral amino acid transporters of the solute carrier 1 [SLC1, alanine serine cysteine transporter 1 (ASCT1), and ASCT2] and SLC38 families [sodium-coupled neutral amino acid transporter 1 (SNAT1), SNAT2, and SNAT4].", "entity1": "SNAT4", "entity2": "glutamine", "span1": [342, 347], "span2": [76, 85]}, "weak_labels": [0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"12973": {"label": 1, "data": {"text": "gammaPKC directly associated with DGKgamma through its accessory domain (AD), depending on Ca2+ as well as phosphatidylserine/diolein in vitro.", "entity1": "gammaPKC", "entity2": "diolein", "span1": [0, 8], "span2": [126, 133]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13450": {"label": 2, "data": {"text": "n-3 and n-6 polyunsaturated fatty acids induce the expression of COX-2 via PPARgamma activation in human keratinocyte HaCaT cells.", "entity1": "PPARgamma", "entity2": "n-3 and n-6 polyunsaturated fatty acids", "span1": [75, 84], "span2": [0, 39]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9663": {"label": 1, "data": {"text": "Eosinophils were isolated from peripheral blood, treated with either buffer or 10(-)10 M to 10(-)6 M FP in the presence of 10 pg/ml human recombinant interleukin-5 (rhIL-5) and activated with formyl-met-leu-phe (FMLP) + cytochalasin B (CB).", "entity1": "human recombinant interleukin-5", "entity2": "formyl-met-leu-phe", "span1": [132, 163], "span2": [192, 210]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1728": {"label": 3, "data": {"text": "Thus, it can be suggested that the inhibitory action of ginseng saponins against the immobilization stress-induced increase of plasma IL-6 level would be in periphery; at least in part, mediated by blocking norepinephrine- and/or epinephrine-induced increase of IL-6 level in macrophage rather than in the brain.", "entity1": "IL-6", "entity2": "ginseng saponins", "span1": [262, 266], "span2": [56, 72]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9032": {"label": 5, "data": {"text": "To study the mechanism underlying this phenomenon, the effects of the nonselective beta-adrenoceptor antagonists propranolol [no intrinsic sympathomimetic activity (ISA)], alprenolol (weak ISA) and mepindolol (strong ISA) on lymphocyte beta 2-adrenoceptor density--assessed by (+/-)-[125I]-iodocyanopindolol (ICYP) binding--and plasma renin activity (PRA) were investigated in male healthy volunteers aged 23-35 years.", "entity1": "beta-adrenoceptor", "entity2": "propranolol", "span1": [83, 100], "span2": [113, 124]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1234": {"label": 0, "data": {"text": "We report herein the location of the binding site for the inhaled anesthetic halothane at the amino acid residue level of resolution in the ligand binding cavity in a prototypical G protein-coupled receptor, bovine rhodopsin.", "entity1": "bovine rhodopsin", "entity2": "amino acid", "span1": [208, 224], "span2": [94, 104]}, "weak_labels": [0, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14598": {"label": 9, "data": {"text": "DCK did not significantly contribute to dFdU monophosphorylation.", "entity1": "DCK", "entity2": "dFdU", "span1": [0, 3], "span2": [40, 44]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"8763": {"label": 8, "data": {"text": "In conclusion, this study expands the understanding of the substrate specificity of UGT2B10, highlighting its preference for tertiary amines with higher affinities and clearance values than those of UGT1A4 and UGT1A3.", "entity1": "UGT1A3", "entity2": "tertiary amines", "span1": [210, 216], "span2": [125, 140]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"1772": {"label": 1, "data": {"text": "We have adenovirally overexpressed beta(1)-adrenoceptors in isolated, cultured adult rat ventricular cardiomyocytes and observed the inotropic potency of isoprenaline and CGP 12177A (in the presence of 1 microm propranolol).", "entity1": "beta(1)-adrenoceptors", "entity2": "propranolol", "span1": [35, 56], "span2": [211, 222]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"348": {"label": 1, "data": {"text": "Affinities for the major nonadrenergic [125I]PIC binding site were highly comparable to human subtype-I1 imidazol(in)e receptor sites in the brain stem (rank order: moxonidine > clonidine > cirazoline > IDX > amiloride).", "entity1": "human subtype-I1 imidazol(in)e receptor", "entity2": "moxonidine", "span1": [88, 127], "span2": [165, 175]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"229": {"label": 3, "data": {"text": "The inhibition of UG synthesis and PR down-regulation by 5 alpha-NET and 3 beta,5 alpha-NET indicates that these NET metabolites possess antiprogestational properties.", "entity1": "PR", "entity2": "3 beta,5 alpha-NET", "span1": [35, 37], "span2": [73, 91]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3254": {"label": 1, "data": {"text": "The other endogenous steroids, androstenedione (ANE) and dihydrotestosterone (DHT), had considerably lower hAR transport rates.", "entity1": "hAR", "entity2": "DHT", "span1": [107, 110], "span2": [78, 81]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"15432": {"label": 2, "data": {"text": "In lymphocytes, the NTPDase and ADA activities were increased in all groups treated with caffeic acid when compared to control (P<0.05).", "entity1": "NTPDase", "entity2": "caffeic acid", "span1": [20, 27], "span2": [89, 101]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4601": {"label": 8, "data": {"text": "In relation to zinc bioavailability, \u03b1-CPPs, \u03b2-CPPs, \u03b1(s1)-CN(64-74)4P and \u03b2-CN(1-25)4P increased zinc uptake.", "entity1": "\u03b2-CPPs", "entity2": "zinc", "span1": [45, 51], "span2": [98, 102]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8800": {"label": 2, "data": {"text": "Here we show that fisetin rapidly increases the levels of both Nrf2 and ATF4 as well as Nrf2- and ATF4-dependent gene transcription via distinct mechanisms.", "entity1": "ATF4", "entity2": "fisetin", "span1": [98, 102], "span2": [18, 25]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2546": {"label": 9, "data": {"text": "Imatinib was also found to inhibit M-CSF-induced osteoclast survival as well as M-CSF-induced osteoclast bone resorbing activity, but was without effect on interleukin 1alpha (IL-1alpha) and receptor activator of nuclear factor kappa B ligand (RANKL)-induced inhibition of osteoclasts apoptosis, further supporting the hypothesis that imatinib may affect mature osteoclasts through the inhibition of c-FMS.", "entity1": "receptor activator of nuclear factor kappa B ligand", "entity2": "Imatinib", "span1": [191, 242], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"898": {"label": 3, "data": {"text": "N(5)-Substituted H(4)biopterin derivatives were not oxidized to products serving as substrates for dihydropteridine reductase and,depending on the substituent, were competitive inhibitors of phenylalanine hydroxylase: N(5)-methyl- and N(5)-hydroxymethyl H(4)biopterin inhibited phenylalanine hydroxylase, whereas N(5)-formyl- and N(5)-acetyl H(4)biopterin had no effect.", "entity1": "phenylalanine hydroxylase", "entity2": "N(5)-hydroxymethyl H(4)biopterin", "span1": [278, 303], "span2": [235, 267]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, 8, -1, -1, 8, -1, 9]},
+	"13202": {"label": 7, "data": {"text": "Herein, comparative genomics and experimental analyses revealed that the mammalian Sec synthase (SecS) is the previously identified pyridoxal phosphate-containing protein known as the soluble liver antigen.", "entity1": "mammalian Sec synthase", "entity2": "pyridoxal phosphate", "span1": [73, 95], "span2": [132, 151]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4206": {"label": 3, "data": {"text": "These data suggest that inhibition of JAK2/STAT3 signaling is a novel mechanism of action for PTE during therapeutic intervention in osteosarcoma cancers.", "entity1": "JAK2", "entity2": "PTE", "span1": [38, 42], "span2": [94, 97]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10476": {"label": 3, "data": {"text": "The specificity of tracer uptake was determined by adding the NET inhibitor imipramine.", "entity1": "NET", "entity2": "imipramine", "span1": [62, 65], "span2": [76, 86]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5470": {"label": 1, "data": {"text": "At 37 degrees C the relative affinity of 3-keto-desogestrel, the major metabolite of desogestrel, for the progesterone receptor in intact MCF-7 cells was twice that of levonorgestrel and Org 2058, three times that of medroxy-progesterone acetate (MPA), 4.5 times that of norethisterone and 5 times that of progesterone and cyproterone acetate whereas at 4 degrees C in the cytosol fraction of MCF-7 cells exposed to molybdate (nontransformed receptor complexes) 3-keto-desogestrel and Org 2058 displayed similar affinity.", "entity1": "progesterone receptor", "entity2": "3-keto-desogestrel", "span1": [106, 127], "span2": [41, 59]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13927": {"label": 1, "data": {"text": "Different VDRAs are known to have differential effects on serum calcium (Ca), which may also affect serum PTH levels since serum Ca regulates PTH secretion mediated by the Ca-sensing receptor (CaSR).", "entity1": "CaSR", "entity2": "Ca", "span1": [193, 197], "span2": [129, 131]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15496": {"label": 0, "data": {"text": "Benzoquinone Reveals a Cysteine-Dependent Desensitization Mechanism of TRPA1.", "entity1": "TRPA1", "entity2": "Cysteine", "span1": [71, 76], "span2": [23, 31]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7103": {"label": 8, "data": {"text": "Proline oxidase (POX), a mitochondrial inner-membrane protein, catalyzes the rate-limiting oxidation of proline to pyrroline- 5-carboxylate (P5C).", "entity1": "POX", "entity2": "proline", "span1": [17, 20], "span2": [104, 111]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"7313": {"label": 8, "data": {"text": "Here, we describe a new photolabile alanine derivative based on protection of alanine with the 4-methoxy-7-nitroindolinyl (MNI) caging group, which we use for pre-steady-state kinetic analysis of alanine transport by ASCT2, SNAT1, and SNAT2.", "entity1": "SNAT1", "entity2": "4-methoxy-7-nitroindolinyl", "span1": [224, 229], "span2": [95, 121]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"9196": {"label": 1, "data": {"text": "We have found that certain naphthalenesulfonamides [e.g., N-6(-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7)] and phenothiazines [e.g., trifluoperazine (TFP)] induce a loss of cell-surface receptors for alpha 2-macroglobulin, and epidermal growth factor (EGF) in fibroblasts.", "entity1": "epidermal growth factor", "entity2": "naphthalenesulfonamides", "span1": [236, 259], "span2": [27, 50]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"8501": {"label": 3, "data": {"text": "The results in vivo show ovalbumin-induced significantly broke Treg/Th17 balance; curcumin treatments markedly attenuated the inflammatory in asthma model by regulating Treg/Th17 balance.", "entity1": "ovalbumin", "entity2": "curcumin", "span1": [25, 34], "span2": [82, 90]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13034": {"label": 8, "data": {"text": "By contrast, 11beta-HSD2 plays a pivotal role in aldosterone target tissues where it catalyses the opposite reaction (i.e. inactivation of cortisol to cortisone) to prevent activation of the mineralocorticoid receptor (MR) by cortisol.", "entity1": "11beta-HSD2", "entity2": "cortisone", "span1": [13, 24], "span2": [151, 160]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"2175": {"label": 3, "data": {"text": "We used mutagenesis of these residues, combined with an investigation of hERG block by close analogs of clofilium and ibutilide, to assess how specific alterations in drug structure affected potency and binding interactions.", "entity1": "hERG", "entity2": "ibutilide", "span1": [73, 77], "span2": [118, 127]}, "weak_labels": [-1, -1, -1, 1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14040": {"label": 5, "data": {"text": "Both outward currents were significantly reduced by the mGluR antagonist MCPG and the CHPG-induced current was blocked by the specific mGluR(5) antagonist MTEP.", "entity1": "mGluR", "entity2": "MCPG", "span1": [56, 61], "span2": [73, 77]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1699": {"label": 9, "data": {"text": "Glycylsarcosine coadministration could inhibit the uptake of cefadroxil in PEPT2(+/+) mice (p < 0.01) but not PEPT2(-/-) mice.", "entity1": "PEPT2", "entity2": "Glycylsarcosine", "span1": [110, 115], "span2": [0, 15]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"10238": {"label": 8, "data": {"text": "During polyamine catabolism, spermine and spermidine are first acetylated by spermidine/spermine N(1)-acetyltransferase (SSAT) and subsequently oxidized by polyamine oxidase (PAO) to produce spermidine and putrescine, respectively.", "entity1": "PAO", "entity2": "putrescine", "span1": [175, 178], "span2": [206, 216]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"14690": {"label": 3, "data": {"text": "In the clinical study, small increases in the AUC(0-inf) of simvastatin [mean ratio (90% CI) of 1.34 (1.22, 1.48)] and rosuvastatin [mean ratio (90% CI) of 1.39 (1.30, 1.49)] were observed when co-administered with GSK1292263, which is consistent with an inhibitory effect on intestinal BCRP and CYP3A4.", "entity1": "BCRP", "entity2": "GSK1292263", "span1": [287, 291], "span2": [215, 225]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6331": {"label": 1, "data": {"text": "Among the current AT1 receptor antagonists, the rank order of the relative binding affinities (highest affinity = 1) is: candesartan 1, telmisartan 10, E3174 (the active metabolite of losartan) 10, tasosartan 20, losartan 50, eprosartan 100 and the prodrug candesartan cilexetil 280.", "entity1": "AT1", "entity2": "losartan", "span1": [18, 21], "span2": [184, 192]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10046": {"label": 3, "data": {"text": "Fenofibrate and GW2331 induced expression of acyl-coenzyme A (CoA) oxidase and enoyl-CoA hydratase and reduced apolipoprotein C-III and phosphoenolpyruvate carboxykinase mRNAs.", "entity1": "apolipoprotein C-III", "entity2": "GW2331", "span1": [111, 131], "span2": [16, 22]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1708": {"label": 8, "data": {"text": "The choroid plexus uptake of [(3)H]cefadroxil was studied in peptide transporter 2 (PEPT2) wild-type and null mice as a function of temperature, transport inhibitors, pH, and saturability.", "entity1": "peptide transporter 2", "entity2": "[(3)H]cefadroxil", "span1": [61, 82], "span2": [29, 45]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"13734": {"label": 8, "data": {"text": "Nicotinamide N-methyltransferase (NNMT) catalyses the conversion of nicotinamide to 1-methylnicotinamide and plays an important role in hepatic detoxification reactions.", "entity1": "Nicotinamide N-methyltransferase", "entity2": "1-methylnicotinamide", "span1": [0, 32], "span2": [84, 104]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, 8, -1]},
+	"11932": {"label": 1, "data": {"text": "To evaluate whether fisetin regulates mTORC1 signaling, we investigated the phosphorylation and kinase activity of the 70-kDa ribosomal protein S6 kinase 1 (S6K1) and mTORC1 in 3T3-L1 preadipocytes.", "entity1": "S6K1", "entity2": "fisetin", "span1": [157, 161], "span2": [20, 27]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6816": {"label": 2, "data": {"text": "These results suggest that pitavastatin efficiently increases apoA-I in the culture medium of HepG2 cells by promoting apoA-I production through inhibition of HMG-CoA reductase and suppression of Rho activity and by protecting apoA-I from catabolism through ABCA1 induction and lipidation of apoA-I.", "entity1": "ABCA1", "entity2": "pitavastatin", "span1": [258, 263], "span2": [27, 39]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"12758": {"label": 2, "data": {"text": "The ratio of TGF-beta1 absorbed light value to GAPDH absorbed light value in the SHR group was 0.887+/-0.019, which was significantly higher than that in WKY group, imidapril group, and irbesartan group with the ratios of 0.780+/-0.018, 0.803+/-0.005, and 0.847+/-0.017, respectively (P<0.01).", "entity1": "GAPDH", "entity2": "irbesartan", "span1": [47, 52], "span2": [186, 196]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5967": {"label": 5, "data": {"text": "These data suggested that ambenonium had a dual effect on tissue responses to acetylcholine-producing potentiation by blockade of acetylcholinesterase and concomitant antagonism by blockade of muscarinic receptors.", "entity1": "muscarinic receptors", "entity2": "ambenonium", "span1": [193, 213], "span2": [26, 36]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"5609": {"label": 3, "data": {"text": "In the present study, we examined the effect of inactivation gating on cisapride block of HERG.", "entity1": "HERG", "entity2": "cisapride", "span1": [90, 94], "span2": [71, 80]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10357": {"label": 1, "data": {"text": "In rat plasma the BrBK half-life values in the absence or in the presence of GW660511X (530 nM) or omapatrilat (50 nM) were 9.31 +/- 1.7, 22.06 +/- 3.1 and 25.3 +/- 1.7 min, respectively and BrBK was degraded into BrBK1-8, BrBK1-7, BrBK1-5 and Br-Phe5 plus BrBK2-9, BrBK4-8 and BrBK2-8 metabolites not found in human plasma.", "entity1": "BrBK", "entity2": "GW660511X", "span1": [18, 22], "span2": [77, 86]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"41": {"label": 3, "data": {"text": "Somatostatin which also inhibits insulin secretion was less efficient (inhibition by 20%).", "entity1": "insulin", "entity2": "Somatostatin", "span1": [33, 40], "span2": [0, 12]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5563": {"label": 2, "data": {"text": "Treatment of cells with BCNU to inhibit glutathione reductase (GR) enhanced the CpG-induced intracellular oxidation and decreased the GSH/GSSG, with increased activation of NF-kappaB and a doubling in the CpG-induced production of IL-6 and TNF-alpha.", "entity1": "NF-kappaB", "entity2": "GSSG", "span1": [173, 182], "span2": [138, 142]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, 2, -1, -1, -1, 3, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"15828": {"label": 8, "data": {"text": "However, enzymes contributing to oxidative metabolism of anandamide, namely cyclooxygenase-1 and Cyp2D6, were increased in the brain of aged mice, possibly enhancing the oxidative breakdown of anandamide.", "entity1": "cyclooxygenase-1", "entity2": "anandamide", "span1": [76, 92], "span2": [57, 67]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12073": {"label": 0, "data": {"text": "Cysteine 360, which was the major adduct accounting for about 90% of the total labeling, is contained within the sequence -WGPTCDGL(I)D-, which is present in all known eukaryote ODCs.", "entity1": "eukaryote ODCs", "entity2": "WGPTCDGL(I)D", "span1": [168, 182], "span2": [123, 135]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13783": {"label": 3, "data": {"text": "The following TK blockers for treatment of various human tumors are in clinical development: Lapatinib (Lapatinib ditosylate, Tykerb, GW-572016), Canertinib (CI-1033), Zactima (ZD6474), Vatalanib (PTK787/ZK 222584), Sorafenib (Bay 43-9006, Nexavar), and Leflunomide (SU101, Arava).", "entity1": "TK", "entity2": "ZD6474", "span1": [14, 16], "span2": [177, 183]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2353": {"label": 4, "data": {"text": "Effect of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist, on motor performance in mice.", "entity1": "MT1/MT2 receptor", "entity2": "TAK-375", "span1": [43, 59], "span2": [21, 28]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"143": {"label": 1, "data": {"text": "These data demonstrate that loperamide differently modifies the stimulatory action of LVP and CRH on ACTH secretion: namely, LVP and loperamide act in an additive manner, while CRH and loperamide interact in a non additive way.", "entity1": "ACTH", "entity2": "loperamide", "span1": [101, 105], "span2": [28, 38]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15315": {"label": 4, "data": {"text": "Moreover, the effects of the DRD3 agonist 7-hydroxy-N,N-dipropyl-2-aminotetralin (7-OH-DPAT)-induced locomotor hypoactivity were significantly increased when DRD3 proteins were abundant.", "entity1": "DRD3", "entity2": "7-hydroxy-N,N-dipropyl-2-aminotetralin", "span1": [158, 162], "span2": [42, 80]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"14674": {"label": 3, "data": {"text": "Genistein also reduced the formation of stress fibers by thrombin and suppressed thrombin-induced phosphorylation of myosin light chain (MLC) on Ser(19)/Thr(18) in endothelial cells (ECs).", "entity1": "thrombin", "entity2": "Genistein", "span1": [81, 89], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6167": {"label": 3, "data": {"text": "A low tyramine diet is recommended if selegiline is used together with nonselective MAO inhibitors or the selective, reversible MAO-A inhibitor, moclobemide.", "entity1": "MAO-A", "entity2": "moclobemide", "span1": [128, 133], "span2": [145, 156]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1478": {"label": 3, "data": {"text": "In clinical trials, eprosartan has been demonstrated to be at least as effective in reducing blood pressure as the ACE inhibitor enalapril, and has significantly lower side effects.", "entity1": "ACE", "entity2": "enalapril", "span1": [115, 118], "span2": [129, 138]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9076": {"label": 1, "data": {"text": "Hence, plasma osteocalcin is a better predictor of retinoid-induced bone effects than serum alkaline phosphatase.", "entity1": "alkaline phosphatase", "entity2": "retinoid", "span1": [92, 112], "span2": [51, 59]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14556": {"label": 5, "data": {"text": "Within the TPBP scaffold, either electronic or steric perturbations to the central piperidine ring led to a loss of selective M(1) allosteric agonism and afforded pan-mAChR antagonism, which was demonstrated to be mediated via the orthosteric site.", "entity1": "mAChR", "entity2": "piperidine", "span1": [167, 172], "span2": [83, 93]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, 5, -1, 6, -1, -1, -1, -1, -1, -1, -1]},
+	"11303": {"label": 1, "data": {"text": "Effects of 5-aza-2'-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease.", "entity1": "fetal hemoglobin", "entity2": "5-aza-2'-deoxycytidine", "span1": [37, 53], "span2": [11, 33]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11604": {"label": 8, "data": {"text": "Hydrogen sulphide (H(2)S) is synthesized from L-cysteine via the action of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS).", "entity1": "CSE", "entity2": "L-cysteine", "span1": [102, 105], "span2": [46, 56]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5020": {"label": 0, "data": {"text": "These variants are expected to encode either a full length (OATP2B1-FL) or shortened protein lacking 22 N-terminus amino acids (OATP2B-Short).", "entity1": "OATP2B1-FL", "entity2": "amino acids", "span1": [60, 70], "span2": [115, 126]}, "weak_labels": [0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9792": {"label": 3, "data": {"text": "New modes of therapy have recently been introduced, and data on the cyclooxygenase-2 (COX-2)-specific inhibitors celecoxib and rofecoxib suggest that these agents will meet the need for safe and effective therapeutic alternatives to conventional NSAIDs.", "entity1": "cyclooxygenase-2", "entity2": "rofecoxib", "span1": [68, 84], "span2": [127, 136]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14247": {"label": 1, "data": {"text": "Androstanol and androstenol, estrone, 17\u03b2-estradiol, TCPOBOP, and CITCO showed compound-specific but similar affinities for both CARs.", "entity1": "CARs", "entity2": "estrone", "span1": [129, 133], "span2": [29, 36]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2630": {"label": 3, "data": {"text": "In leukemia cell lines MV4-11 and EOL-1, sorafenib treatment resulted in decreased cell proliferation and inhibition of FLT3 signaling.", "entity1": "FLT3", "entity2": "sorafenib", "span1": [120, 124], "span2": [41, 50]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10142": {"label": 3, "data": {"text": "Accordingly, docking of different COX inhibitors, including selective and non-selective ligands: rofecoxib, ketoprofen, suprofen, carprofen, zomepirac, indomethacin, diclofenac and meclofenamic acid were undertaken using the AMBER program.", "entity1": "COX", "entity2": "carprofen", "span1": [34, 37], "span2": [130, 139]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11040": {"label": 4, "data": {"text": "A selective retinoid X receptor agonist bexarotene (LGD1069, targretin) inhibits angiogenesis and metastasis in solid tumours.", "entity1": "retinoid X receptor", "entity2": "LGD1069", "span1": [12, 31], "span2": [52, 59]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1797": {"label": 3, "data": {"text": "Epidermal growth factor receptor inhibitors currently under investigation include the small molecules gefitinib (Iressa, ZD1839) and erlotinib (Tarceva, OSI-774), as well as monoclonal antibodies such as cetuximab (IMC-225, Erbitux).", "entity1": "Epidermal growth factor receptor", "entity2": "gefitinib", "span1": [0, 32], "span2": [102, 111]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13294": {"label": 1, "data": {"text": "Sorafenib (BAY43-9006, Nexavar) is a small molecule B-RAF inhibitor that is used for the treatment of renal cell carcinoma, and has been shown to have activity against receptor tyrosine kinases from the platelet-derived growth factor receptor (PDGFR) and vascular endothelial growth factor receptor (VEGFR) families.", "entity1": "platelet-derived growth factor receptor", "entity2": "Nexavar", "span1": [203, 242], "span2": [23, 30]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11461": {"label": 8, "data": {"text": "Spermidine/spermine N1-acetyltransferase (SSAT) is a key enzyme in the control of polyamine levels in human cells, as acetylation of spermidine and spermine triggers export or degradation.", "entity1": "Spermidine/spermine N1-acetyltransferase", "entity2": "spermine", "span1": [0, 40], "span2": [148, 156]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9048": {"label": 2, "data": {"text": "The apparent affinity of benzodiazepine receptors for clonazepam in mice receiving alprazolam (0.05 mg/kg) was unchanged from that in untreated control mice, an observation suggesting that low doses of alprazolam increased receptor number.", "entity1": "benzodiazepine receptors", "entity2": "alprazolam", "span1": [25, 49], "span2": [202, 212]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6653": {"label": 8, "data": {"text": "The potency of MrIA was greater for inhibition of uptake by hNET of [3H]norepinephrine (Ki 1.89 microM) than [3H]dopamine (Ki 4.33 microM), and the human dopamine transporter and serotonin transporter were not inhibited by MrIA (to 7 microM).", "entity1": "hNET", "entity2": "[3H]norepinephrine", "span1": [60, 64], "span2": [68, 86]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, 9]},
+	"4942": {"label": 3, "data": {"text": "Moreover, protein and mRNA levels of DSS-induced proinflammatory cytokines in colon, including TNF-\u03b1, IL-1\u03b2, IL-18, IL-17A and IFN-\u03b3, were markedly suppressed by Fc11a-2.", "entity1": "IL-17A", "entity2": "Fc11a-2", "span1": [116, 122], "span2": [162, 169]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8558": {"label": 3, "data": {"text": "As a potent synthetic APN inhibitor (IC50=850nM, versus bestatin of 8.1\u03bcM), LB-4b was determined to have more significant block effects to cancer cell invasion and angiogenesis than bestatin.", "entity1": "APN", "entity2": "LB-4b", "span1": [22, 25], "span2": [76, 81]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11340": {"label": 1, "data": {"text": "Thus, p95ErbB2 represents a target for therapeutic intervention, and one that is sensitive to GW572016 therapy.", "entity1": "p95ErbB2", "entity2": "GW572016", "span1": [6, 14], "span2": [94, 102]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4236": {"label": 1, "data": {"text": "Functional and biochemical studies indicated that TES signaling involved activity of the phosphoinositide 3 (PI3) kinase-protein kinase B (Akt) cascade initiated by activation of the androgen receptor and culminated in enhanced production of cGMP and microvascular vasodilation.", "entity1": "protein kinase B", "entity2": "TES", "span1": [121, 137], "span2": [50, 53]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"5862": {"label": 1, "data": {"text": "When delta-receptor binding was determined by using [3H]DPDPE, a 40-50% decrease in binding in the midbrain and cortex, and 25-35% decrease in binding in the striatum were observed after 3 or 4 days of DPDPE treatment.", "entity1": "delta-receptor", "entity2": "DPDPE", "span1": [5, 19], "span2": [202, 207]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8090": {"label": 2, "data": {"text": "E235 also activated DNA damage response signaling, resulting in increased levels of Ser15-phosphorylated p53, \u03b3-H2AX, and phosphorylated checkpoint kinase 2 (Chk2), although E235 does not appear to cause physical DNA damage.", "entity1": "Chk2", "entity2": "E235", "span1": [158, 162], "span2": [0, 4]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"13006": {"label": 1, "data": {"text": "Phospholipase C beta (PLC-beta)-coupled G protein-coupled receptor (GPCR) activities traditionally are assessed by measuring Ca2+ triggered by D-myo-inositol 1,4,5-trisphosphate (IP3), a PLC-beta hydrolysis product, or by measuring the production of inositol phosphate using cumbersome radioactive assays.", "entity1": "Phospholipase C beta", "entity2": "D-myo-inositol 1,4,5-trisphosphate", "span1": [0, 20], "span2": [143, 177]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"9601": {"label": 3, "data": {"text": "All GCs including the antagonistic compound RU486 efficiently reduced NF-kappaB-mediated transactivation to comparable extents, suggesting that ligand-induced nuclear localization of the GR is sufficient for transrepression.", "entity1": "NF-kappaB", "entity2": "RU486", "span1": [70, 79], "span2": [44, 49]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, 3, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2054": {"label": 0, "data": {"text": "Mutation of arginine 228 to lysine enhances the glucosyltransferase activity of bovine beta-1,4-galactosyltransferase I.", "entity1": "bovine beta-1,4-galactosyltransferase I", "entity2": "arginine", "span1": [80, 119], "span2": [12, 20]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"746": {"label": 3, "data": {"text": "We report here that lovastatin, a drug clinically used for lowering cholesterol levels, inhibits the interaction of human LFA-1 with its counter-receptor intercellular adhesion molecule-1.", "entity1": "intercellular adhesion molecule-1", "entity2": "lovastatin", "span1": [154, 187], "span2": [20, 30]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7578": {"label": 1, "data": {"text": "In both rodent and primate animal models, the binding of radiolabeled d-MPH to dopamine transporter was found to be selective, saturable, and reversible, whereas binding of l-MPH was diffuse and nonspecific.", "entity1": "dopamine transporter", "entity2": "l-MPH", "span1": [79, 99], "span2": [173, 178]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"10301": {"label": 3, "data": {"text": "Sildenafil exhibits inhibitory potency against PDE5 and a 10-fold lower dose-related inhibitory potency against rod outer segment PDE6, the predominant PDE in the phototransduction cascade in rods.", "entity1": "PDE", "entity2": "Sildenafil", "span1": [152, 155], "span2": [0, 10]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6860": {"label": 5, "data": {"text": "Effect of bosentan (ETA/ETB receptor antagonist) on metabolic changes during stress and diabetes.", "entity1": "ETB", "entity2": "bosentan", "span1": [24, 27], "span2": [10, 18]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13844": {"label": 8, "data": {"text": "BACKGROUND: Peripheral inflammatory pain is associated with an upregulation of spinal cord COX-2 (cyclooxygenase-2), with a subsequent increase in central prostaglandin E2 (PGE2) levels associated with the development of hyperalgesia.", "entity1": "COX-2", "entity2": "PGE2", "span1": [91, 96], "span2": [173, 177]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6020": {"label": 3, "data": {"text": "Indomethacin, piroxicam, and sulindac sulfide were found to preferentially inhibit PGHS-1.", "entity1": "PGHS-1", "entity2": "Indomethacin", "span1": [83, 89], "span2": [0, 12]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4146": {"label": 2, "data": {"text": "Cotreatments of 5, 10 and 20 \u00b5g/mL concentrations of MEP with aflatoxin B(1) decreased the frequencies of SCE and the malondialdehyde level and increased amount of superoxide dismutase, glutathione and glutathione peroxidase which were decreased by aflatoxin.", "entity1": "superoxide dismutase", "entity2": "aflatoxin B(1)", "span1": [164, 184], "span2": [62, 76]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11770": {"label": 1, "data": {"text": "Pin1 was adducted in MDA-MB-231 breast cancer cells treated with 8-alkynyl-HNE as judged by click chemistry conjugation with biotin followed by streptavidin-based pulldown and Western blotting with anti-Pin1 antibody.", "entity1": "Pin1", "entity2": "8-alkynyl-HNE", "span1": [0, 4], "span2": [65, 78]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6628": {"label": 9, "data": {"text": "On the other hand, pranlukast did not modify the eosinophil spontaneous adhesion to the resting or IL-4 plus TNF-alpha-stimulated pulmonary endothelial cells.", "entity1": "TNF-alpha", "entity2": "pranlukast", "span1": [109, 118], "span2": [19, 29]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"5228": {"label": 2, "data": {"text": "In addition, vinblastine induces the DNA-binding activities of the transcription factor NF-\u03baB, HSF1, AP-1, and ATF-2, together with the expression of HSP70 and Bax proteins.", "entity1": "Bax", "entity2": "vinblastine", "span1": [160, 163], "span2": [13, 24]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4666": {"label": 3, "data": {"text": "To determine whether dysregulation of SIRT1 promotes NADPH oxidase-dependent production of reactive oxygen species (ROS) and impairs endothelial function we assessed the effects of three structurally different inhibitors of SIRT1 (nicotinamide, sirtinol, EX527) in aorta segments isolated from young Wistar rats.", "entity1": "SIRT1", "entity2": "nicotinamide", "span1": [224, 229], "span2": [231, 243]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"10165": {"label": 5, "data": {"text": "Olopatadine hydrochloride (olopatadine, 11-[(Z)-3-(dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid monohydrochloride) is a novel antiallergic/histamine H1-receptor antagonistic drug that was synthesized and evaluated in our laboratories.", "entity1": "histamine H1-receptor", "entity2": "Olopatadine hydrochloride", "span1": [165, 186], "span2": [0, 25]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15566": {"label": 2, "data": {"text": "Puerarin administration enhanced glutathione (GSH) activity, glial cell line-derived neurotrophic factor (GDNF) expression and PI3K/Akt pathway activation, which might ameliorate MPTP injection-induced progressive elevation of reactive oxygen species (ROS) formation in mice.", "entity1": "GDNF", "entity2": "Puerarin", "span1": [106, 110], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14279": {"label": 8, "data": {"text": "Cytochrome b5 has shown to be an essential component in P450 3A4 catalyzed 5-hydroxyelzasonan formation and provides insights on the disconnect between human liver microsomes data and that of rCYP.", "entity1": "P450 3A4", "entity2": "5-hydroxyelzasonan", "span1": [56, 64], "span2": [75, 93]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"1956": {"label": 5, "data": {"text": "bolus injection of, either physiological saline (0.3 ml/kg; control), or the antagonists SB224289 (300 microg/kg; 5-HT1B), BRL15572 (300 microg/kg; 5-HT1D), rauwolscine (300 microg/kg; alpha2), SB224289 + BRL15572 (300 microg/kg each), SB224289 + rauwolscine (300 microg/kg each), BRL15572 + rauwolscine (300 microg/kg each), rauwolscine (300 microg/kg) + prazosin (100 microg/kg; alpha1), SB224289 (300 microg/kg) + prazosin (100 microg/kg), SB224289 (300 microg/kg) + rauwolscine (300 microg/kg) + prazosin (100 microg/kg), SB224289 (300 microg/kg) + prazosin (100 microg/kg) + BRL44408 (1,000 microg/kg; alpha2A), SB224289 (300 microg/kg) + prazosin (100 microg/kg)+ imiloxan (1,000 microg/kg; alpha2B), or SB224289 (300 microg/kg) + prazosin (100 microg/kg) + MK912 (300 microg/kg; alpha2C).", "entity1": "5-HT1B", "entity2": "SB224289", "span1": [114, 120], "span2": [89, 97]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4101": {"label": 3, "data": {"text": "The upregulation of calpain, tBid and caspase-3 activity were further inhibited by treatment with EGTA in the presence of ALD.", "entity1": "caspase-3", "entity2": "EGTA", "span1": [38, 47], "span2": [98, 102]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12574": {"label": 8, "data": {"text": "Glutathione-independent prostaglandin D synthase [prostaglandin-H2 D-isomerase; (5Z,13E)-(15S)-9 alpha,11 alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase, EC 5.3.99.2] is an enzyme responsible for biosynthesis of prostaglandin D2 in the central nervous system.", "entity1": "prostaglandin D synthase", "entity2": "prostaglandin D2", "span1": [24, 48], "span2": [223, 239]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1107": {"label": 1, "data": {"text": "In view of the role of CA in acid-base balance as well as the fact that an increase or decrease in its activity is accompanied by an increase or decrease in intra- and extracellular pH, our results suggest that: firstly, CA activation induced by indomethacin might cause changes in COX activity; secondly, PGs are synthetized as a consequence of the changes in COX activity, a hypothesis that requires further study.", "entity1": "COX", "entity2": "indomethacin", "span1": [282, 285], "span2": [246, 258]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4464": {"label": 3, "data": {"text": "Catalpol reduced the expression of pro-inflammatory mediates, such as monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-\u03b1 (TNF-\u03b1), inducible NO synthase (iNOS), and receptor for AGE (RAGE).", "entity1": "monocyte chemotactic protein-1", "entity2": "Catalpol", "span1": [70, 100], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6290": {"label": 1, "data": {"text": "(-)-Pindolol, which possesses significant affinity for 5-HT1A, 5-HT1B, and beta 1/2-adrenergic receptors (AR)s, dose-dependently increased extracellular levels of dopamine (DA) and noradrenaline (NAD) versus 5-HT, in dialysates of the frontal cortex (FCX), but not accumbens and striatum, of freely-moving rats.", "entity1": "5-HT1A", "entity2": "(-)-Pindolol", "span1": [55, 61], "span2": [0, 12]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"6734": {"label": 3, "data": {"text": "Compounds of several other structural families, including the quinoxaline AG1296, the bis(1H-2-indolyl)-1-methanone D-65476, the indolinones SU5416 and SU11248, the indolocarbazoles PKC412 and CEP-701, and the piperazonyl quinazoline CT53518, are potent inhibitors of Flt3 kinase.", "entity1": "Flt3", "entity2": "PKC412", "span1": [268, 272], "span2": [182, 188]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2625": {"label": 3, "data": {"text": "The demonstration that sorafenib exhibits potent target inhibition and efficacy in FLT3-driven models suggests that this compound may have a therapeutic benefit for patients with FLT3-driven leukemias.", "entity1": "FLT3", "entity2": "sorafenib", "span1": [83, 87], "span2": [23, 32]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5808": {"label": 8, "data": {"text": "A cDNA encoding the complete amino acid sequence of aminoacylase 1 (N-acylamino acid aminohydrolase, ACY-1) [EC 3.5.1.14], a dimeric metalloprotein having two Zn2+ in the molecule, which catalyzes the deacylation of N-acylated L-amino acids except L-aspartic acid, has been isolated from porcine kidney lambda gt10 cDNA library and sequenced.", "entity1": "N-acylamino acid aminohydrolase", "entity2": "N-acylated L-amino acids", "span1": [68, 99], "span2": [216, 240]}, "weak_labels": [0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"11149": {"label": 8, "data": {"text": "Levodopa is absorbed in the small bowel and is rapidly catabolized by aromatic-L-amino-acid decarboxylase (AADC) and catechol-O-methyltransferase (COMT).", "entity1": "COMT", "entity2": "Levodopa", "span1": [147, 151], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3043": {"label": 8, "data": {"text": "PGE(2) is synthesized from arachidonic acid by cyclooxygenases (COX) and prostaglandin E synthases (PGES) and mediates its biological activity through binding to the four prostanoid receptors EP(1) through EP(4).", "entity1": "cyclooxygenases", "entity2": "PGE(2)", "span1": [47, 62], "span2": [0, 6]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15296": {"label": 0, "data": {"text": "While HIF-1\u03b1 in hypoxia translocates to the nucleus where it transcribes the target genes including vascular endothelial growth factor (VEGF) mRNA, HIF-1\u03b1 is degraded under normoxia, which involves its proline hydroxylation and subsequent binding to the von Hippel-Lindau protein-Elongin B-Elogin C (VBC) complex.", "entity1": "HIF-1\u03b1", "entity2": "proline", "span1": [148, 154], "span2": [202, 209]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6434": {"label": 9, "data": {"text": "RESULT(S): Buserelin acetate, a GnRH agonist (0.1-10 ng/mL), had no significant effect on MCP-1 expression, whereas danazol (10(-7)-10(-5) M), a testosterone analog, and dexamethasone, an anti-inflammatory glucocorticoid hormone (10(-12)-10(-6)M), showed a direct and a dose-dependent inhibitory effect on MCP-1 expression.", "entity1": "MCP-1", "entity2": "Buserelin acetate", "span1": [90, 95], "span2": [11, 28]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11479": {"label": 8, "data": {"text": "These data suggest that endothelial NO synthesis depends on the activity of arginase II in mitochondria and l-arginine carriers in cell membrane.", "entity1": "arginase II", "entity2": "NO", "span1": [76, 87], "span2": [36, 38]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11941": {"label": 3, "data": {"text": "We also observed that fisetin efficiently suppressed the phosphorylation of Akt, S6K1 and mTORC1 in adipose tissue.", "entity1": "mTORC1", "entity2": "fisetin", "span1": [90, 96], "span2": [22, 29]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14211": {"label": 6, "data": {"text": "Galantamine is a reversible, competitive acetylcholinesterase (AChE) inhibitor and allosteric potentiating ligand of nicotinic acetylcholine receptors (nAChR-APL) that shares many common structural elements with morphinan-based opioids.", "entity1": "nicotinic acetylcholine receptors", "entity2": "Galantamine", "span1": [117, 150], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1]},
+	"15675": {"label": 3, "data": {"text": "Moreover, curcumin could also down-regulate the expression and activity of matrix metalloproteinase-9 (MMP-9).", "entity1": "matrix metalloproteinase-9", "entity2": "curcumin", "span1": [75, 101], "span2": [10, 18]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1821": {"label": 3, "data": {"text": "To investigate the mechanism and consequences of inhibition of QR2 by the quinolines further, we have used steady-state and transient-state kinetics to define the mechanism of QR2.", "entity1": "QR2", "entity2": "quinolines", "span1": [63, 66], "span2": [74, 84]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3008": {"label": 3, "data": {"text": "Inhibition of dipeptidyl peptidase-IV (DPP-IV) by atorvastatin.", "entity1": "dipeptidyl peptidase-IV", "entity2": "atorvastatin", "span1": [14, 37], "span2": [50, 62]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3963": {"label": 1, "data": {"text": "Here, we demonstrate that peptidyl-prolyl cis/trans-isomerase A1 (Pin1), an enzyme that catalyzes the conversion of the peptide bond of pSer/pThr-Pro moieties in signaling proteins from cis to trans, is highly susceptible to HNE modification.", "entity1": "Pin1", "entity2": "HNE", "span1": [66, 70], "span2": [225, 228]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, 8, -1]},
+	"2733": {"label": 3, "data": {"text": "A KCC inhibitor-[(dihydroindenyl)oxy] alkanoic acid (DIOA)-blocked RVD more in HCEC than RCEC.", "entity1": "KCC", "entity2": "[(dihydroindenyl)oxy] alkanoic acid", "span1": [2, 5], "span2": [16, 51]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14254": {"label": 3, "data": {"text": "Our results show that PILO converts a transient cortical depression induced by LFS600 into a robust LTD, stable for at least 4 h. When applied after LFS600, PILO does not change either mPFC basal neurotransmission or late LTD. Our data also indicate that NMDA receptor pre-activation is essential to the muscarinic enhancement of mPFC synaptic depression, since AP7 microinjection into the mPFC blocked the conversion of transient depression into long-lasting LTD produced by PILO.", "entity1": "NMDA receptor", "entity2": "AP7", "span1": [255, 268], "span2": [362, 365]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, 8, 9]},
+	"2531": {"label": 8, "data": {"text": "We found that reduction of the carcinogenic hydroxylamines of the aromatic amine 4-aminobiphenyl (4-ABP; found in cigarette smoke) and the heterocyclic amine 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP; found in grilled meats) was indeed catalyzed by a purified system containing only human b5R and cyt b5.", "entity1": "cyt b5", "entity2": "4-ABP", "span1": [311, 317], "span2": [98, 103]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"14460": {"label": 9, "data": {"text": "Unlike the majority of G protein-coupled receptors, the prostaglandin E(2) (PGE(2)) E-prostanoid 3 (EP3) receptor binds agonist with high affinity that is insensitive to the presence of guanosine 5[prime]-O-(3-thio)triphosphate (GTP\u03b3S).", "entity1": "prostaglandin E(2) (PGE(2)) E-prostanoid 3 (EP3) receptor", "entity2": "GTP\u03b3S", "span1": [56, 113], "span2": [229, 234]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12559": {"label": 1, "data": {"text": "Risperidone was 120-fold more selective for the alpha 1B-adrenoceptor with respect to the alpha 1A-adrenoceptor (Ki values: 2.3 +/- 1.2 nM and 283.6 +/- 174.1 nM respectively).", "entity1": "alpha 1B-adrenoceptor", "entity2": "Risperidone", "span1": [48, 69], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15441": {"label": 3, "data": {"text": "When mice were treated ip with the major neonicotinoid imidacloprid (IMI), metabolism by CYP oxidation reactions was not appreciably affected, whereas the AOX-generated nitrosoguanidine metabolite was decreased by 30% with tungsten and 56% with hydralazine and 86% in the AOX-deficient mice.", "entity1": "AOX", "entity2": "tungsten", "span1": [155, 158], "span2": [223, 231]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"7085": {"label": 2, "data": {"text": "Similar to menthol, both camphor and cinnamaldehyde (initially reported to be specific activators of TRPV3 and TRPA1, respectively) also modulate other thermoTRPs.", "entity1": "TRPA1", "entity2": "cinnamaldehyde", "span1": [111, 116], "span2": [37, 51]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8418": {"label": 3, "data": {"text": "Moreover, since reduced levels of p21CIP1 and Chk2 proteins but no change in p53 levels could be detected in MCF-7 cells after BSC 3g or 3n treatment our results suggest that BSC treated cells die from lethal mitosis.", "entity1": "Chk2", "entity2": "BSC", "span1": [46, 50], "span2": [127, 130]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9287": {"label": 4, "data": {"text": "Moreover, clenbuterol HCl (0.1-0.5 mg/kg, IP), a lipophilic beta 2-adrenoceptor agonist, significantly increased the duration of basal aggressive behavior.", "entity1": "beta 2-adrenoceptor", "entity2": "clenbuterol HCl", "span1": [60, 79], "span2": [10, 25]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15275": {"label": 5, "data": {"text": "RATIONALE: The selective CRF(1) (corticotropin releasing factor type 1) receptor antagonist SSR125543 has been previously shown to attenuate the long-term cognitive deficit produced by traumatic stress exposure.", "entity1": "CRF(1) (corticotropin releasing factor type 1) receptor", "entity2": "SSR125543", "span1": [25, 80], "span2": [92, 101]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"6096": {"label": 5, "data": {"text": "Pretreatment with the dopamine D1 receptor antagonist, SCH23390, and the NMDA receptor antagonist, MK-801, blocked amantadine induction of Fos in the striatum.", "entity1": "dopamine D1 receptor", "entity2": "SCH23390", "span1": [22, 42], "span2": [55, 63]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6441": {"label": 2, "data": {"text": "Clenbuterol was without effect on NGF mRNA levels in L929 cells, whereas CB1093 caused significant increases in both NGF mRNA and protein levels in both 3T3 and L929 cells.", "entity1": "NGF", "entity2": "CB1093", "span1": [117, 120], "span2": [73, 79]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14115": {"label": 3, "data": {"text": "Overexpression of CRBN wild-type protein, but not CRBN(YW/AA) mutant protein, in KMS12 myeloma cells, amplified pomalidomide-mediated reductions in c-myc and IRF4 expression and increases in p21(WAF-1) expression.", "entity1": "IRF4", "entity2": "pomalidomide", "span1": [158, 162], "span2": [112, 124]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"245": {"label": 3, "data": {"text": "Indomethacin inhibited both hCOX-1 and hCOX-2, whereas NS-398 and Dup-697 selectively inhibited hCOX-2.", "entity1": "hCOX-1", "entity2": "Indomethacin", "span1": [28, 34], "span2": [0, 12]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13179": {"label": 5, "data": {"text": "injection of a subthreshold dose of picrotoxin, a use-dependent gamma-aminobutyric acid receptor antagonist, reduces cortical electroencephalogram delta power and transiently inhibits spontaneous seizure activity in ADNFLE mutant mice.", "entity1": "gamma-aminobutyric acid receptor", "entity2": "picrotoxin", "span1": [64, 96], "span2": [36, 46]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"490": {"label": 1, "data": {"text": "There is, however, much information on the direct (acute and chronic) effects of alcohol on the binding properties of opioid receptors, as well as modulation of opioid peptide synthesis and secretion (e.g.", "entity1": "opioid receptors", "entity2": "alcohol", "span1": [118, 134], "span2": [81, 88]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10533": {"label": 1, "data": {"text": "The ability of this cis-acting RAR-RXR binding element to activate transcription in response to RA also depended on downstream sequences where an octamer transcription factor 1 (Oct1) site and a nuclear factor of activated T cells (NFATc) site between this element and the transcriptional start, as well as a cyclic AMP response element binding factor (CREB) site between the transcriptional start and first exon of the blr1 gene, were necessary.", "entity1": "octamer transcription factor 1", "entity2": "RA", "span1": [146, 176], "span2": [96, 98]}, "weak_labels": [-1, -1, -1, 1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1260": {"label": 2, "data": {"text": "Central 5-HT3 receptor stimulation by m-CPBG increases blood glucose in rats.", "entity1": "5-HT3", "entity2": "m-CPBG", "span1": [8, 13], "span2": [38, 44]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13513": {"label": 1, "data": {"text": "Taken together H(2)O(2)-mediated oxidation affects calcium binding in calmodulin leading to perturbed calcium homeostasis and perturbed l-phenylalanine-uptake in the epidermis of acute vitiligo.", "entity1": "calmodulin", "entity2": "calcium", "span1": [70, 80], "span2": [51, 58]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1465": {"label": 0, "data": {"text": "By introducing the mutant-derived genomic library into a non-L-proline-utilizing strain, the mutant was found to carry an allele of the wild-type PRO1 gene encoding gamma-glutamyl kinase, which resulted in a single amino acid replacement; Asp (GAC) at position 154 was replaced by Asn (AAC).", "entity1": "gamma-glutamyl kinase", "entity2": "Asp", "span1": [165, 186], "span2": [239, 242]}, "weak_labels": [0, 0, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6503": {"label": 3, "data": {"text": "Pemetrexed disodium (ALIMTA) is a novel antimetabolite that inhibits at least three folate-dependent enzymes, thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase.", "entity1": "thymidylate synthase", "entity2": "ALIMTA", "span1": [110, 130], "span2": [21, 27]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7757": {"label": 2, "data": {"text": "Rescue of both impaired extinction acquisition and deficient extinction consolidation/retrieval was achieved with prior extinction training administration of valproic acid (a GABAergic enhancer and HDAC inhibitor) or AMN082 [metabotropic glutamate receptor 7 (mGlu7) agonist], while MS-275 or PEPA (AMPA receptor potentiator) failed to affect extinction acquisition in S1 mice.", "entity1": "AMPA receptor", "entity2": "MS-275", "span1": [299, 312], "span2": [283, 289]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13458": {"label": 2, "data": {"text": "n-3 and n-6 polyunsaturated fatty acids induce the expression of COX-2 via PPARgamma activation in human keratinocyte HaCaT cells.", "entity1": "COX-2", "entity2": "n-3 and n-6 polyunsaturated fatty acids", "span1": [65, 70], "span2": [0, 39]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8969": {"label": 5, "data": {"text": "Computer-assisted analysis of these curvilinear Schild plots in a two-receptor system indicated that alpha 1-adrenoceptor populations responsible for the constrictive response are predominantly (approximately 80-90%) low affinity sites for the two antagonists (pKd approximately 8.1 for WB4101 and pKd approximately 7.1 for 5-methyl-urapidil) and a small population (approximately 10-20%) are high affinity sites (pKd approximately 9.1 for both WB4101 and 5-methyl-urapidil), which was in good agreement with radioligand binding studies.", "entity1": "alpha 1-adrenoceptor", "entity2": "5-methyl-urapidil", "span1": [101, 121], "span2": [324, 341]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11531": {"label": 3, "data": {"text": "The results suggest that the suppression of TLR4 activity by auranofin may be the molecular mechanism through which auranofin exerts anti-rheumatic activity.", "entity1": "TLR4", "entity2": "auranofin", "span1": [44, 48], "span2": [61, 70]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4845": {"label": 2, "data": {"text": "Subsequent analysis revealed that cucurbitacin I strongly activates RhoA and the Rho effector Rho kinase (ROCK) in breast cancer cells and induces the formation of stress fibers.", "entity1": "ROCK", "entity2": "cucurbitacin I", "span1": [106, 110], "span2": [34, 48]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4764": {"label": 3, "data": {"text": "Furthermore, BRN-250 inhibited the VEGF-induced phosphorylation and intracellular tyrosine kinase activity of VEGF receptor 2 (VEGFR2) and the activation of its downstream AKT pathway.", "entity1": "VEGF", "entity2": "BRN-250", "span1": [35, 39], "span2": [13, 20]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1346": {"label": 1, "data": {"text": "Several active analogues were also evaluated for their ability to block uptake of DA, 5-HT, and NE and inhibit binding of [(125)I] RTI-55 at HEK-hDAT, HEK-hSERT, and HEK-hNET cells.", "entity1": "hSERT", "entity2": "[(125)I] RTI-55", "span1": [155, 160], "span2": [122, 137]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9573": {"label": 4, "data": {"text": "Although beta3AR mRNA was detectable in Con A-activated T lymphocytes, we could not demonstrate a functional activity in the regulation of cytokine expression: the beta3AR agonist BRL 37344 had no effect on the accumulation of the studied cytokine mRNAs, and did not significantly affect cellular cAMP levels.", "entity1": "beta3AR", "entity2": "BRL 37344", "span1": [164, 171], "span2": [180, 189]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"4566": {"label": 4, "data": {"text": "Adenosine and N(6)-cyclopentyl-adenosine (CPA, A1R agonist) constricted MVs but not MAs.", "entity1": "A1R", "entity2": "CPA", "span1": [47, 50], "span2": [42, 45]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"5914": {"label": 3, "data": {"text": "Phenelzine is a more potent monoamine oxidase inhibitor than is N2-acetylphenelzine.", "entity1": "monoamine oxidase", "entity2": "N2-acetylphenelzine", "span1": [28, 45], "span2": [64, 83]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12868": {"label": 1, "data": {"text": "This aminophospholipid \"flippase\" selectively transports PS to the cytosolic leaflet of the bilayer and is sensitive to vanadate, Ca(2+), and modification by sulfhydryl reagents.", "entity1": "flippase", "entity2": "sulfhydryl", "span1": [24, 32], "span2": [158, 168]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"6858": {"label": 1, "data": {"text": "To test this, we studied the possible effect of the endothelin receptor antagonist, bosentan (50 and 100 mg kg(-1)) on serum glucose and insulin levels as well as on liver glycogen contents in normoglycemic stressed animals.", "entity1": "insulin", "entity2": "bosentan", "span1": [137, 144], "span2": [84, 92]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1851": {"label": 3, "data": {"text": "Some of these derivatives showed good inhibitory potency against two human CA isozymes involved in important physiological processes, CA I, and CA II, of the same order of magnitude as the clinically used drugs acetazolamide and methazolamide.", "entity1": "CA II", "entity2": "methazolamide", "span1": [144, 149], "span2": [229, 242]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8469": {"label": 1, "data": {"text": "Of the new compounds, Dmt(1)-(R)-\u03b2Pro(2)-Trp(3)-(2-furyl)Map(4) (analogue 12) displayed the highest affinity toward MOR, in the picomolar range (Ki(\u03bc) = 3.72 pM).", "entity1": "MOR", "entity2": "Trp", "span1": [116, 119], "span2": [41, 44]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15551": {"label": 1, "data": {"text": "Further analyses revealed that CdTe-QD exposure resulted in apoptosis, indicated by changes in levels of caspase-3 activity, poly ADP-ribose polymerase (PARP) cleavage and phosphatidylserine externalization.", "entity1": "PARP", "entity2": "CdTe", "span1": [153, 157], "span2": [31, 35]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2610": {"label": 8, "data": {"text": "Pharmacogenetic analysis of two genes, the warfarin metabolic enzyme CYP2C9 and warfarin target enzyme, vitamin K epoxide reductase complex 1 VKORC1, confirmed their influence on warfarin maintenance dose.", "entity1": "CYP2C9", "entity2": "warfarin", "span1": [69, 75], "span2": [43, 51]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"265": {"label": 0, "data": {"text": "Cyclodiene resistance in D. melanogaster has been attributed to a mutation resulting in an Ala302-->Ser replacement in the Rdl GABA receptor subunit and in D. simulans to an homologous Ala-->Ser or Gly replacement.", "entity1": "Rdl GABA receptor", "entity2": "Ser", "span1": [123, 140], "span2": [191, 194]}, "weak_labels": [-1, 0, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9681": {"label": 3, "data": {"text": "Desipramine treatment decreases 3H-nisoxetine binding and norepinephrine transporter mRNA in SK-N-SHSY5Y cells.", "entity1": "norepinephrine transporter", "entity2": "Desipramine", "span1": [58, 84], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"9334": {"label": 1, "data": {"text": "Kainate and AMPA activated the heteromeric channel with significantly higher affinities than observed for EAA3a alone.", "entity1": "EAA3a", "entity2": "AMPA", "span1": [106, 111], "span2": [12, 16]}, "weak_labels": [-1, -1, -1, -1, -1, 1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"16019": {"label": 5, "data": {"text": "The involvement of the various DA receptor subtypes in the motor effects of N/OFQ and NOP receptor antagonists was evaluated pharmacologically, using D1/D5 (SCH23390), D2/D3 (raclopride, amisulpride) and D3 (S33084) receptor antagonists, and by using D2 receptor knockout mice.", "entity1": "D3", "entity2": "S33084", "span1": [204, 206], "span2": [208, 214]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14101": {"label": 1, "data": {"text": "Our studies demonstrate that thalidomide, lenalidomide and another immunomodulatory drug, pomalidomide, bound endogenous CRBN and recombinant CRBN-DNA damage binding protein-1 (DDB1) complexes.", "entity1": "DDB1", "entity2": "lenalidomide", "span1": [177, 181], "span2": [42, 54]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"378": {"label": 3, "data": {"text": "Dexamethasone (DEX) inhibited the anti-CD3-induced production of IL-4, IL-5 and IFN-gamma in all 20 clones tested.", "entity1": "IL-4", "entity2": "Dexamethasone", "span1": [65, 69], "span2": [0, 13]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"1639": {"label": 1, "data": {"text": "2-Amino-3-[3-hydroxy-5-(2-thiazolyl)-4-isoxazolyl]propionic acid (1) is a potent AMPA receptor agonist with moderate affinity for native kainic acid (KA) receptors, whereas (S)-E-4-(2,2-dimethylpropylidene)glutamic acid (3) show high affinity for the GluR5 subtype of KA receptors and much lower affinity for the GluR2 subtype of AMPA receptors.", "entity1": "kainic acid (KA) receptors", "entity2": "2-Amino-3-[3-hydroxy-5-(2-thiazolyl)-4-isoxazolyl]propionic acid", "span1": [137, 163], "span2": [0, 64]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6418": {"label": 2, "data": {"text": "The induction in UCP-3 expression was not accompanied by changes in the mitochondrial membrane potential of rat primary preadipocytes after bezafibrate or Wy-14,643 treatment.", "entity1": "UCP-3", "entity2": "bezafibrate", "span1": [17, 22], "span2": [140, 151]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"2965": {"label": 1, "data": {"text": "Change in affinity for cGMP, vardenafil, sildenafil, or IBMX in Y612F, H613A, L765A, or F786A was less, but affinity of H613A or F786A for tadalafil was weakened 37- and 17-fold, respectively.", "entity1": "F786A", "entity2": "cGMP", "span1": [88, 93], "span2": [23, 27]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10198": {"label": 3, "data": {"text": "100 micromol/L rifampicin inhibited OATP-C- and OATP8-, OATP-B- and OATP-A-mediated BSP uptake by 66%, 96%, 25%, and 49%, respectively.", "entity1": "OATP-A", "entity2": "rifampicin", "span1": [68, 74], "span2": [15, 25]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15942": {"label": 1, "data": {"text": "We also recorded a significant correlation between M value increase and the decrease of vaspin, visfatin, and omentin-1 obtained with vildagliptin+metformin.", "entity1": "omentin-1", "entity2": "vildagliptin", "span1": [110, 119], "span2": [134, 146]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8273": {"label": 8, "data": {"text": "Methadone N-demethylation in vitro is catalyzed by hepatic cytochrome P4502B6 (CYP2B6) and CYP3A4, but clinical disposition is often attributed to CYP3A4.", "entity1": "CYP2B6", "entity2": "N", "span1": [79, 85], "span2": [10, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"1687": {"label": 3, "data": {"text": "Moreover, recent in vitro studies suggest that memantine abrogates beta-amyloid (Abeta) toxicity and possibly inhibits Abeta production.", "entity1": "beta-amyloid", "entity2": "memantine", "span1": [67, 79], "span2": [47, 56]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"9091": {"label": 9, "data": {"text": "In contrast to diethylcarbamazine, piriprost (U-60,257; 6,9-deepoxy-6,9-(phenylimino)-delta 6,8-prostaglandin I1), which inhibits the formation of sulfidopeptide leuktrienes in RBL cells at the 5-lipoxygenase step (EC50 5 microM), did not inhibit the leukotriene synthetase of these cells.", "entity1": "leukotriene synthetase", "entity2": "6,9-deepoxy-6,9-(phenylimino)-delta 6,8-prostaglandin I1", "span1": [251, 273], "span2": [56, 112]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"15464": {"label": 8, "data": {"text": "The present study demonstrated that human multidrug resistance-associated protein 3 vesicles accepted conjugated 3\u03b2-hydroxy-\u0394(5)-bile acids along with common bile acids such as glycocholic acid and taurolithocholic acid 3-sulfate.", "entity1": "human multidrug resistance-associated protein 3", "entity2": "3\u03b2-hydroxy-\u0394(5)-bile acids", "span1": [36, 83], "span2": [113, 139]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11575": {"label": 8, "data": {"text": "OBJECTIVE: The aim was to test whether the common deletion [T/-] in the promoter of FADS2 affects the PUFA biosynthetic pathway and consequently modifies the effect of alpha-linolenic acid (ALA) on myocardial infarction (MI).", "entity1": "FADS2", "entity2": "alpha-linolenic acid", "span1": [84, 89], "span2": [168, 188]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11623": {"label": 8, "data": {"text": "We isolated partial cDNAs that codified for enzymes implicated in the anthocyanin biosynthesis such as l-phenylalanine ammonia-lyase (PAL) and chalcone synthase (CHS), and an antioxidant enzyme such as ascorbate peroxidase (APX).", "entity1": "APX", "entity2": "anthocyanin", "span1": [224, 227], "span2": [70, 81]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10744": {"label": 3, "data": {"text": "These findings suggest that the mechanism of antiproliferative toxicity of capecitabine is at least partly due to TS inhibitory activity of its active metabolite 5-fluoro-2'-deoxyuridine monophosphate (FdUMP).", "entity1": "TS", "entity2": "FdUMP", "span1": [114, 116], "span2": [202, 207]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"190": {"label": 1, "data": {"text": "Readdition of a small quantity of dialyzed serum to cytosol preparations yielded a profile of steroid binding similar to that of the kidney mineralocorticoid receptor (aldosterone greater than desoxycorticosterone greater than corticosterone).", "entity1": "mineralocorticoid receptor", "entity2": "desoxycorticosterone", "span1": [140, 166], "span2": [193, 213]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7764": {"label": 3, "data": {"text": "Electroencephalographic recordings during substance consumption showed reduced alpha activity and P300 latencies in the nicotine group compared to the control group.", "entity1": "P300", "entity2": "nicotine", "span1": [98, 102], "span2": [120, 128]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9593": {"label": 1, "data": {"text": "Crystallographic comparison with the structurally related rat tyrosine hydroxylase binary complex with the oxidized cofactor 7,8-dihydrobiopterin revealed overlapping binding sites for the catechols and the cofactor, compatible with a competitive type of inhibition of the catechols versus BH4.", "entity1": "rat tyrosine hydroxylase", "entity2": "catechols", "span1": [58, 82], "span2": [189, 198]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, 7, -1, -1, -1, -1, -1, -1]},
+	"8968": {"label": 5, "data": {"text": "Computer-assisted analysis of these curvilinear Schild plots in a two-receptor system indicated that alpha 1-adrenoceptor populations responsible for the constrictive response are predominantly (approximately 80-90%) low affinity sites for the two antagonists (pKd approximately 8.1 for WB4101 and pKd approximately 7.1 for 5-methyl-urapidil) and a small population (approximately 10-20%) are high affinity sites (pKd approximately 9.1 for both WB4101 and 5-methyl-urapidil), which was in good agreement with radioligand binding studies.", "entity1": "alpha 1-adrenoceptor", "entity2": "WB4101", "span1": [101, 121], "span2": [287, 293]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14717": {"label": 3, "data": {"text": "Pharmacological inhibition of MTORC1 with rapamycin abrogated the insulin-induced phosphorylation of EIF4EBP1, RPS6KB1 and its downstream effector, RPS6.", "entity1": "EIF4EBP1", "entity2": "rapamycin", "span1": [101, 109], "span2": [42, 51]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6054": {"label": 3, "data": {"text": "Neither ryanodine nor EGTA inhibited down-regulation of alpha-AR mRNA by NE.", "entity1": "alpha-AR", "entity2": "NE", "span1": [56, 64], "span2": [73, 75]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15633": {"label": 3, "data": {"text": "In conclusion, nobiletin attenuates HGF-induced HepG2 cells metastasis involving both ERK and PI3K/Akt pathways and are potentially useful as anti-metastatic agents for the treatment of hepatoma.", "entity1": "HGF", "entity2": "nobiletin", "span1": [36, 39], "span2": [15, 24]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8496": {"label": 3, "data": {"text": "AlCl3 markedly reduced AA performance and activities of cytochrome c oxidase (COX) and acetylcholinesterase (AChE) in all regions.", "entity1": "AChE", "entity2": "AlCl3", "span1": [109, 113], "span2": [0, 5]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11071": {"label": 1, "data": {"text": "We have examined the effects on the activities of three calmodulin-dependent enzymes (cAMP phosphodiesterase, caldesmon kinase and myosin light chain kinase) of the dihydropyridine Ca2+ channel blocker felodipine and three analogues (p-chloro, oxidized and t-butyl) exhibiting different pharmacological potencies.", "entity1": "calmodulin-dependent enzymes", "entity2": "felodipine", "span1": [56, 84], "span2": [202, 212]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10448": {"label": 8, "data": {"text": "Formation of pyruvate by SDH is a two-step reaction in which the hydroxyl group of serine is cleaved to produce aminoacrylate, and then the aminoacrylate is deaminated by nonenzymatic hydrolysis to produce pyruvate.", "entity1": "SDH", "entity2": "pyruvate", "span1": [25, 28], "span2": [13, 21]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"3861": {"label": 3, "data": {"text": "HSYA suppressed the expression of TLR-4, Myd88, ICAM-1, TNF\u03b1, IL-1\u03b2 and IL-6 at the mRNA and protein level, and inhibited the adhesion of leukocytes to A549 cells.", "entity1": "TNF\u03b1", "entity2": "HSYA", "span1": [56, 60], "span2": [0, 4]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14083": {"label": 3, "data": {"text": "Berberine only suppressed the expression of pp38 among the evaluated signaling molecules.", "entity1": "pp38", "entity2": "Berberine", "span1": [44, 48], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8466": {"label": 3, "data": {"text": "In conclusion, hinokitiol may inhibit platelet activation by inhibiting the PLC\u03b32-PKC cascade and hydroxyl radical formation, followed by suppressing the activation of MAPKs and Akt.", "entity1": "MAPKs", "entity2": "hinokitiol", "span1": [168, 173], "span2": [15, 25]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5268": {"label": 2, "data": {"text": "Nox4 oxidase activity is thought to be constitutive and regulated at the transcriptional level; however, we challenge this point of view and suggest that specific quinone derivatives could modulate this activity.", "entity1": "oxidase", "entity2": "quinone", "span1": [5, 12], "span2": [163, 170]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13273": {"label": 8, "data": {"text": "We studied in a clinical trial whether isolated isoflavone treatment in postmenopausal women could affect reverse cholesterol transport as evaluated by adenosine triphosphate-binding cassette A1- (ABCA1), dependent cholesterol efflux from macrophages.", "entity1": "adenosine triphosphate-binding cassette A1", "entity2": "cholesterol", "span1": [152, 194], "span2": [215, 226]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"11304": {"label": 9, "data": {"text": "Naloxone (alone) treatment of rats had no effect on the levels of CREB and p-CREB protein in the nucleus accumbens.", "entity1": "p-CREB", "entity2": "Naloxone", "span1": [75, 81], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"347": {"label": 9, "data": {"text": "Preliminary evidence suggests that ergotamine may not occupy striatal dopamine D2-receptors to a large extent and thus may not cross the blood brain barrier in large quantities.", "entity1": "dopamine D2-receptors", "entity2": "ergotamine", "span1": [70, 91], "span2": [35, 45]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"4382": {"label": 8, "data": {"text": "We investigated the effects of the dose of and the number of times an inducer was administered and the duration of induction of hepatic and intestinal cytochrome P450 3A (CYP3A) in rats using dexamethasone 21-phosphate (DEX-P) and midazolam (MDZ) as an inducer and a substrate to CYP3A, respectively.", "entity1": "CYP3A", "entity2": "MDZ", "span1": [171, 176], "span2": [242, 245]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"6843": {"label": 1, "data": {"text": "Differences in cobalamin and folate levels with the MTRR A66G and MS A2756G polymorphisms were noted.", "entity1": "A2756G", "entity2": "cobalamin", "span1": [69, 75], "span2": [15, 24]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"1069": {"label": 3, "data": {"text": "Triacsin C, a competitive inhibitor of both ACS1 and ACS4, inhibited ACS activity similarly in endoplasmic reticulum, MAM, and mitochondria, suggesting that a hitherto unidentified triacsin-sensitive ACS is present in mitochondria.", "entity1": "ACS4", "entity2": "Triacsin C", "span1": [53, 57], "span2": [0, 10]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3865": {"label": 3, "data": {"text": "HSYA treatment also decreased NF-\u03baB p65 nuclear translocation and inhibited the phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK).", "entity1": "p38", "entity2": "HSYA", "span1": [99, 102], "span2": [0, 4]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1229": {"label": 3, "data": {"text": "In addition, we found that MCP-1 transcription and translation was completely inhibited by mimosine, while MIP-2 transcription and translation was partially inhibited at 30 and 40 days; yet it was totally inhibited after 10 and 20 days in encysted diaphragm tissue infected by T. spiralis.", "entity1": "MIP-2", "entity2": "mimosine", "span1": [107, 112], "span2": [91, 99]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1812": {"label": 3, "data": {"text": "In comparison to diphenylhydantoin, the novel chloro-substituted alpha-hydroxyphenylamide compounds produced as much as a 20-fold greater tonic and frequency-dependent blockade of Na(V)1.5 channels with an IC(50) value of 14.5 microM.", "entity1": "Na(V)1.5", "entity2": "diphenylhydantoin", "span1": [180, 188], "span2": [17, 34]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"13635": {"label": 0, "data": {"text": "Top1p clamps around duplex DNA, wherein the core and C-terminal domains are connected by extended alpha-helices (linker domain), which position the active site Tyr of the C-terminal domain within the catalytic pocket.", "entity1": "Top1p", "entity2": "C", "span1": [0, 5], "span2": [171, 172]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14029": {"label": 1, "data": {"text": "Although genetic polymorphisms in the endothelial nitric oxide synthase (eNOS) gene may impair endogenous NO formation, there is little information about how eNOS polymorphisms and haplotypes affect the responses to sildenafil.", "entity1": "eNOS", "entity2": "sildenafil", "span1": [158, 162], "span2": [216, 226]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6761": {"label": 2, "data": {"text": "Hydralazine induced rapid and transient expression of HIF-1alpha and downstream targets of HIF (endothelin-1, adrenomedullin, haem oxygenase 1, and vascular endothelial growth factor [VEGF]) in endothelial and smooth muscle cells and induced endothelial cell-specific proliferation.", "entity1": "VEGF", "entity2": "Hydralazine", "span1": [184, 188], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8870": {"label": 3, "data": {"text": "Phosphorylation of c-Src, which was shown to be activated by AhR ligands, was also increased by I3S and TCDD, and blocking of c-Src activity by 4-amino-5-(4-chlorophenyl)-7-(t-butyl) pyrazolo[3,4-d]pyrimidine (PP2) inhibited phosphorylation of both c-Src and STAT3, raising a possibility that stimulatory activities of I3S and TCDD on Th17 differentiation could be exerted via increased phosphorylation of c-Src, which in turn stimulates STAT3 activation.", "entity1": "c-Src", "entity2": "4-amino-5-(4-chlorophenyl)-7-(t-butyl) pyrazolo[3,4-d]pyrimidine", "span1": [126, 131], "span2": [144, 208]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9043": {"label": 5, "data": {"text": "Bevantolol: a beta-1 adrenoceptor antagonist with unique additional actions.", "entity1": "beta-1 adrenoceptor", "entity2": "Bevantolol", "span1": [14, 33], "span2": [0, 10]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6893": {"label": 8, "data": {"text": "NPC1L1 could recently be identified as a major sterol transporter for the intestinal uptake of cholesterol as well as plant sterols.", "entity1": "NPC1L1", "entity2": "sterols", "span1": [0, 6], "span2": [124, 131]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"254": {"label": 8, "data": {"text": "The enzyme cyclo-oxygenase catalyses the oxygenation of arachidonic acid, leading to the formation of prostaglandins.", "entity1": "cyclo-oxygenase", "entity2": "prostaglandins", "span1": [11, 26], "span2": [102, 116]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"11481": {"label": 1, "data": {"text": "OBJECTIVE: To compare the cyclooxygenase (COX) activity and anti-inflammatory effects of the nonsteroidal anti-inflammatory drugs (NSAIDs) ketorolac tromethamine (ketorolac) and bromfenac sodium (bromfenac).", "entity1": "COX", "entity2": "bromfenac sodium", "span1": [42, 45], "span2": [178, 194]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5000": {"label": 9, "data": {"text": "In contrast, their effects on MRP2 varied with two (V-4, V-6) inhibiting E217\u03b2G transport (IC50's 2.0, 9.2 \u03bcM), two (V-3, III-1) stimulating transport (>2-fold), while CGP I-5 had no effect.", "entity1": "MRP2", "entity2": "CGP", "span1": [30, 34], "span2": [168, 171]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"13561": {"label": 8, "data": {"text": "Dimethylarginine dimethylaminohydrolase (DDAH) metabolizes asymmetric dimethylarginine to generate L-citrulline and is present in large quantities in the kidney.", "entity1": "DDAH", "entity2": "L-citrulline", "span1": [41, 45], "span2": [99, 111]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5570": {"label": 8, "data": {"text": "Dimethylarginine dimethylaminohydrolase 1 (DDAH1) is an enzyme that metabolizes methylated arginine to citrulline and methylamine, thus working to produce nitric oxide (NO).", "entity1": "Dimethylarginine dimethylaminohydrolase 1", "entity2": "methylamine", "span1": [0, 41], "span2": [118, 129]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"14468": {"label": 1, "data": {"text": "Seven point mutations were introduced into the conserved motif in the second extracellular loop (ECII) of EP3, resulting in acquisition of GTP-sensitive agonist binding.", "entity1": "ECII", "entity2": "GTP", "span1": [97, 101], "span2": [139, 142]}, "weak_labels": [-1, -1, 0, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11172": {"label": 1, "data": {"text": "Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution.", "entity1": "acetylcholinesterase", "entity2": "(-)-galanthamine", "span1": [13, 33], "span2": [49, 65]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7207": {"label": 1, "data": {"text": "In conclusion, our results indicate that Cd increases BC cell proliferation in vitro by stimulating Akt, ERK1/2 and PDGFRalpha kinases activity likely by activating c-fos, c-jun and PDGFA by an ERalpha-dependent mechanism.", "entity1": "ERalpha", "entity2": "Cd", "span1": [194, 201], "span2": [41, 43]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2806": {"label": 3, "data": {"text": "In addition, cells pre-treated with DL-propargylglycine (PAG, 3 mM), a CSE inhibitor, reduced the formation of H(2)S in caerulein treated cells, suggesting that CSE may be the main enzyme involved in H(2)S formation in mouse acinar cells.", "entity1": "CSE", "entity2": "PAG", "span1": [71, 74], "span2": [57, 60]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1088": {"label": 3, "data": {"text": "Moreover, the rank order for potency in inhibiting acetylcholinesterase (ambenonium>neostigmine=physostigmine =tacrine>pyridostigmine=edrophonium=galanthamine >desoxypeganine>parathion>gramine) indicated that the most effective inhibitors of acetylcholinesterase also displaced [3H]-oxotremorine-M to the greatest extent.", "entity1": "acetylcholinesterase", "entity2": "parathion", "span1": [51, 71], "span2": [175, 184]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5262": {"label": 3, "data": {"text": "Synthesis and antitumor activity of 1,3,4-oxadiazole possessing 1,4-benzodioxan moiety as a novel class of potent methionine aminopeptidase type II inhibitors.", "entity1": "methionine aminopeptidase type II", "entity2": "1,4-benzodioxan", "span1": [114, 147], "span2": [64, 79]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2031": {"label": 1, "data": {"text": "Secondly, the affinity of GAD for PLP was increased in the presence of ApoCaM.", "entity1": "GAD", "entity2": "PLP", "span1": [26, 29], "span2": [34, 37]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14710": {"label": 3, "data": {"text": "Pharmacological inhibition of MTORC1 with rapamycin abrogated the insulin-induced phosphorylation of EIF4EBP1, RPS6KB1 and its downstream effector, RPS6.", "entity1": "insulin", "entity2": "rapamycin", "span1": [66, 73], "span2": [42, 51]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15044": {"label": 8, "data": {"text": "Its head-space aroma displayed new volatile phytomolecules and also had higher levels of green volatiles from the lipoxygenase (LOX)-pathway (one having as precursors the polyunsaturated fatty acids containing a cis-cis-1,4-pentadiene system).", "entity1": "LOX", "entity2": "polyunsaturated fatty acids", "span1": [128, 131], "span2": [171, 198]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13266": {"label": 9, "data": {"text": "Thus, isoflavone supplementation did not affect ABCA1-dependent cholesterol efflux to serum.", "entity1": "ABCA1", "entity2": "isoflavone", "span1": [48, 53], "span2": [6, 16]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"13383": {"label": 1, "data": {"text": "We identified suramin as a compound that binds to human SIRT5 and showed that it inhibits SIRT5 NAD(+)-dependent deacetylase activity with an IC(50) value of 22 microM.", "entity1": "human SIRT5", "entity2": "suramin", "span1": [50, 61], "span2": [14, 21]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5694": {"label": 2, "data": {"text": "The incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic peptide are secreted by enteroendocrine cells and augment glucose-induced insulin secretion in response to food ingestion in a glucose-dependent manner.", "entity1": "insulin", "entity2": "glucose", "span1": [157, 164], "span2": [210, 217]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"4563": {"label": 3, "data": {"text": "In addition, ethanol induced degradation of DNA methyltransferases (DNMT-1, DNMT-3a, and DNMT-3b), as well as the methyl CpG-binding proteins (MeCP-2, MBD-2 and MBD-3), in MEF cells by the proteasomal pathway.", "entity1": "MBD-3", "entity2": "ethanol", "span1": [161, 166], "span2": [13, 20]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7248": {"label": 1, "data": {"text": "Recently, it was reported that METH, AMPH, POHA, and the TAs para-tyramine (TYR) and beta-phenylethylamine (PEA) stimulate cAMP production in human embryonic kidney (HEK)-293 cells expressing rat trace amine-associated receptor 1 (rTAAR1).", "entity1": "rat trace amine-associated receptor 1", "entity2": "PEA", "span1": [192, 229], "span2": [108, 111]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"1409": {"label": 8, "data": {"text": "Gemfibrozil, a lipid-lowering drug, inhibited cytokine-induced production of NO and the expression of inducible nitric-oxide synthase (iNOS) in human U373MG astroglial cells and primary astrocytes.", "entity1": "iNOS", "entity2": "nitric-oxide", "span1": [135, 139], "span2": [112, 124]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"4009": {"label": 3, "data": {"text": "Compared with the untreated colitis group, the curcumin-treated group showed significant decreases in the disease activity index, colonic mucosa damage index, histological score, myeloperoxidase activity, and expressions of NF-\u03baB mRNA, IL-27 mRNA, TLR4 protein, NF-\u03baB p65 protein, and IL-27 p28 protein (p < 0.05).", "entity1": "IL-27", "entity2": "curcumin", "span1": [236, 241], "span2": [47, 55]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13134": {"label": 2, "data": {"text": "CONCLUSION(S): Short-term exposure of mifepristone in new starters of DMPA increases the expression of endometrial ERalpha, PRAB, PRB, and SRC-1 and promotes cell proliferation.", "entity1": "PRB", "entity2": "mifepristone", "span1": [130, 133], "span2": [38, 50]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15585": {"label": 1, "data": {"text": "A series of N-substituted lobelane analogues was synthesized and evaluated for their [(3)H]dihydrotetrabenazine binding affinity at the vesicular monoamine transporter and for their inhibition of vesicular [(3)H]dopamine uptake.", "entity1": "vesicular monoamine transporter", "entity2": "lobelane", "span1": [136, 167], "span2": [26, 34]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"2157": {"label": 3, "data": {"text": "Thalidomide reduced COX-2 expression accompanied by a decrease of bcl-2 protein, TNFalpha, VEGF, GSH and an increased cytochrome c, but had no effect on that of COX-1, in MCF-7 and HL-60.", "entity1": "bcl-2", "entity2": "Thalidomide", "span1": [66, 71], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1631": {"label": 1, "data": {"text": "Changes of phosphorylation of cAMP response element binding protein in rat nucleus accumbens after chronic ethanol intake: naloxone reversal.", "entity1": "cAMP response element binding protein", "entity2": "ethanol", "span1": [30, 67], "span2": [107, 114]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7824": {"label": 2, "data": {"text": "Cellular release of AChE by SH-SY5Y is significantly enhanced by the muscarinic acetylcholine receptor (mAChR) agonists carbachol or muscarine, with the effect of carbachol blocked by the mAChR antagonist atropine.", "entity1": "AChE", "entity2": "muscarine", "span1": [20, 24], "span2": [133, 142]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1769": {"label": 1, "data": {"text": "This study demonstrates enhanced cardiostimulation by CGP 12177A (in the presence of propranolol) in rat ventricular myocytes overexpressing beta(1)-adrenoceptors, mediated by a Gs/cAMP signalling pathway.", "entity1": "Gs", "entity2": "cAMP", "span1": [178, 180], "span2": [181, 185]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6997": {"label": 3, "data": {"text": "Furthermore, PS liposome-induced PGE2 production was significantly suppressed by indomethacin, a preferential COX-1 inhibitor, but not by NS-398, a selective COX-2 inhibitor.", "entity1": "COX-2", "entity2": "NS-398", "span1": [158, 163], "span2": [138, 144]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, 9]},
+	"83": {"label": 1, "data": {"text": "The high-affinity binding of L-noradrenaline to phenylalanine hydroxylase, as studied by equilibrium microdialysis (anaerobically) and ultrafiltration (aerobically), shows positive cooperativity (h = 1.9); at pH 7.2 and 20 degrees C the rat enzyme binds about 0.5 mol L-noradrenaline/mol subunit with a half-maximal binding (S50) at 0.25 microM L-noradrenaline.", "entity1": "phenylalanine hydroxylase", "entity2": "L-noradrenaline", "span1": [48, 73], "span2": [345, 360]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2676": {"label": 8, "data": {"text": "In kidneys, stimulation of adenylyl cyclase causes egress of cAMP, conversion of cAMP to AMP by ecto-phosphodiesterase, and metabolism of AMP to adenosine by ecto-5'-nucleotidase.", "entity1": "phosphodiesterase", "entity2": "cAMP", "span1": [101, 118], "span2": [81, 85]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1]},
+	"452": {"label": 5, "data": {"text": "Pretreatment of the tissues with combined 5-HT1/5-HT2 antagonists, methysergide (1 microM) or methiothepin (0.1 microM), significantly attenuated the inhibitory effect of epinastine on the noncholinergic contraction.", "entity1": "5-HT2", "entity2": "methysergide", "span1": [48, 53], "span2": [67, 79]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15660": {"label": 9, "data": {"text": "Remarkably, 3-HPT gives no inhibition of HDAC 1.", "entity1": "HDAC 1", "entity2": "3-HPT", "span1": [41, 47], "span2": [12, 17]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1740": {"label": 0, "data": {"text": "The model includes 607 of the 773 amino acids of L-CPT I, and the positions of carnitine, CoA and the palmitoyl group were assigned by superposition and docking analysis.", "entity1": "L-CPT I", "entity2": "amino acids", "span1": [49, 56], "span2": [34, 45]}, "weak_labels": [0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"16044": {"label": 3, "data": {"text": "In contrast, TSH-induced differentiation of progenitor cells, in particular the expression of the sodium iodide symporter, was significantly inhibited by 17beta-oestradiol.In conclusion, oestrogen stimulated growth and simultaneously inhibited differentiation of thyroid nodules derived stem/progenitor cells.", "entity1": "sodium iodide symporter", "entity2": "17beta-oestradiol", "span1": [98, 121], "span2": [154, 171]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15549": {"label": 1, "data": {"text": "Further analyses revealed that CdTe-QD exposure resulted in apoptosis, indicated by changes in levels of caspase-3 activity, poly ADP-ribose polymerase (PARP) cleavage and phosphatidylserine externalization.", "entity1": "caspase-3", "entity2": "CdTe", "span1": [105, 114], "span2": [31, 35]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10618": {"label": 1, "data": {"text": "Furthermore, GABA receptors of horizontal cells were modulated by extracellular application of diazepam, zolpidem, methyl 6,7-dimethoxy-4-ethyl-beta-carboxylate, pentobarbital, and alphaxalone, thus showing typical pharmacological properties of CNS GABAA receptors.", "entity1": "GABA receptors", "entity2": "pentobarbital", "span1": [13, 27], "span2": [162, 175]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12815": {"label": 3, "data": {"text": "Treatment with carvedilol reversed both protein and mRNA of HIF-1alpha, VEGF, BNP, and NGF-beta to the baseline values.", "entity1": "BNP", "entity2": "carvedilol", "span1": [78, 81], "span2": [15, 25]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2022": {"label": 5, "data": {"text": "BACKGROUND: Pranlukast, a cysteinyl leukotriene receptor 1 (CysLTR1) antagonist, inhibits not only airway smooth muscle contraction, but also allergic inflammation.", "entity1": "CysLTR1", "entity2": "Pranlukast", "span1": [60, 67], "span2": [12, 22]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"13138": {"label": 2, "data": {"text": "In the present study, glucose-stimulated insulin secretion was significantly increased in GalN-treated rats compared to controls.", "entity1": "insulin", "entity2": "GalN", "span1": [41, 48], "span2": [90, 94]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5161": {"label": 8, "data": {"text": "These results indicate a major role of CYP2B6 in ketamine N-demethylation in vitro and a significant impact of the CYP2B6*6 allele on enzyme-ketamine binding and catalytic activity.", "entity1": "CYP2B6*6", "entity2": "ketamine", "span1": [115, 123], "span2": [141, 149]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15349": {"label": 3, "data": {"text": "Coumarin 7-hydroxylation, catalyzed by P450 2A13, was strongly inhibited by 2'-methoxy-5,7-dihydroxyflavone, 2-ethynylnaphthalene, 2'-methoxyflavone, 2-naphththalene propargyl ether, acenaphthene, acenaphthylene, naphthalene, 1-acetylpyrene, flavanone, chrysin, 3-ethynylphenanthrene, flavone, and 7-hydroxyflavone; these chemicals induced Type I spectral changes with low Ks values.", "entity1": "P450 2A13", "entity2": "7-hydroxyflavone", "span1": [39, 48], "span2": [298, 314]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"2007": {"label": 0, "data": {"text": "Point-mutation studies indicate that four amino acids, Leu/Phe(7.38), Leu/Phe(7.43), Ala/Pro(7.46), and Pro/Cys(7.47) in TMH7 are critical for ligand selectivity as well as receptor conformation.", "entity1": "TMH7", "entity2": "Phe", "span1": [121, 125], "span2": [74, 77]}, "weak_labels": [0, -1, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15733": {"label": 4, "data": {"text": "Among 12 parabens with linear alkyl chains ranging in length from C1 to C12, heptylparaben (C7) and pentylparaben (C5) showed the most potent ER\u03b1 and ER\u03b2 agonistic activity in the order of 10(-7)M and 10(-8)M, respectively, and the activities decreased in a stepwise manner as the alkyl chain was shortened to C1 or lengthened to C12.", "entity1": "ER\u03b1", "entity2": "parabens", "span1": [142, 145], "span2": [9, 17]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10144": {"label": 8, "data": {"text": "Non-steroidal anti-inflammatory drugs (NSAIDs) are competitive inhibitors of cyclooxygenase (COX), the enzyme that mediates biosynthesis of prostaglandins and thromboxanes from arachidonic acid.", "entity1": "COX", "entity2": "prostaglandins", "span1": [93, 96], "span2": [140, 154]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7384": {"label": 8, "data": {"text": "Proline dehydrogenase (PRODH) and Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH) catalyze the two-step oxidation of proline to glutamate.", "entity1": "Proline dehydrogenase", "entity2": "glutamate", "span1": [0, 21], "span2": [135, 144]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"1556": {"label": 5, "data": {"text": "Kynurenic acid (KA) is an endogenous glutamate receptor antagonist at the level of the different ionotropic glutamate receptors.", "entity1": "glutamate receptor", "entity2": "Kynurenic acid", "span1": [37, 55], "span2": [0, 14]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"255": {"label": 8, "data": {"text": "The enzyme cyclo-oxygenase catalyses the oxygenation of arachidonic acid, leading to the formation of prostaglandins.", "entity1": "cyclo-oxygenase", "entity2": "arachidonic acid", "span1": [11, 26], "span2": [56, 72]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"6651": {"label": 1, "data": {"text": "A comparison of the results with previous data for desipramine and cocaine inhibition of norepinephrine uptake by the mutant hNETs reveals that MrIA binding to hNET occurs at a site that is distinct from but overlaps with the binding sites for tricyclic antidepressants and cocaine.", "entity1": "hNET", "entity2": "cocaine", "span1": [160, 164], "span2": [274, 281]}, "weak_labels": [-1, -1, 0, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"16007": {"label": 1, "data": {"text": "The preventive effect of uncarboxylated osteocalcin against free fatty acid-induced endothelial apoptosis through the activation of phosphatidylinositol 3-kinase/Akt signaling pathway: Uncarboxylated osteocalcin and endothelial apoptosis.", "entity1": "phosphatidylinositol 3-kinase", "entity2": "free fatty acid", "span1": [132, 161], "span2": [60, 75]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9148": {"label": 3, "data": {"text": "Xanthines are classical antagonists for adenosine receptors for many of their pharmacological actions may be due to blockade of adenosine receptors.", "entity1": "adenosine receptors", "entity2": "Xanthines", "span1": [128, 147], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4482": {"label": 3, "data": {"text": "In this study, we assessed the effects of clopidogrel and clarithromycin, known CYP2B6 and CYP3A inhibitors, respectively, on the enantioselective disposition of racemic sibutramine in conjunction with CYP2B6 polymorphisms in humans.", "entity1": "CYP3A", "entity2": "clarithromycin", "span1": [91, 96], "span2": [58, 72]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2579": {"label": 2, "data": {"text": "Pretreatment with dexamethasone significantly suppressed nasal allergy-like behaviors, up-regulation of histamine content, HDC activity and HDC mRNA induced by TDI in TDI-sensitized rats.", "entity1": "HDC", "entity2": "TDI", "span1": [140, 143], "span2": [167, 170]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"98": {"label": 3, "data": {"text": "Catecholamines (adrenaline, noradrenaline and dopamine) are potent inhibitors of phenylalanine 4-monooxygenase (phenylalanine hydroxylase, EC 1.14.16.1).", "entity1": "phenylalanine 4-monooxygenase", "entity2": "Catecholamines", "span1": [81, 110], "span2": [0, 14]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15452": {"label": 3, "data": {"text": "Of the compounds active in the present assay system, the most potent compound 7, platyphyllonol-5-O-\u03b2-d-xylopyranoside, significantly suppressed the induction of peroxisome proliferator activated receptor \u03b3 (PPAR\u03b3 and CCAAT/enhancer binding protein \u03b1 (C/EBP\u03b1) protein expression, and inhibited adipocyte differentiation induced by troglitazone, a PPAR\u03b3 agonist.", "entity1": "CCAAT/enhancer binding protein \u03b1", "entity2": "platyphyllonol-5-O-\u03b2-d-xylopyranoside", "span1": [218, 250], "span2": [81, 118]}, "weak_labels": [-1, -1, -1, 1, -1, -1, 2, -1, 2, -1, -1, -1, -1, 3, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"702": {"label": 5, "data": {"text": "The putative alpha 1L-adrenoceptor antagonist JTH-601, but not the alpha 1B-adrenoceptor antagonist chloroethylclonidine (10 microM) antagonized noradrenaline-induced contractions of SMA.", "entity1": "alpha 1B-adrenoceptor", "entity2": "chloroethylclonidine", "span1": [67, 88], "span2": [100, 120]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"7921": {"label": 8, "data": {"text": "Heterologous expression of rCtr1 in HEK293 cells (HEK/rCtr1 cells) increased the uptake and cytotoxicity of copper, oxaliplatin, cisplatin and carboplatin, in comparison to isogenic vector-transfected control cells.", "entity1": "rCtr1", "entity2": "cisplatin", "span1": [54, 59], "span2": [129, 138]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9377": {"label": 1, "data": {"text": "Recovery from modulation by cyclothiazide was slower for GluR-AiBi and GluR-AoBi than for GluR-AiBo and GluR-AoBo.", "entity1": "GluR-AoBo", "entity2": "cyclothiazide", "span1": [104, 113], "span2": [28, 41]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13007": {"label": 1, "data": {"text": "Phospholipase C beta (PLC-beta)-coupled G protein-coupled receptor (GPCR) activities traditionally are assessed by measuring Ca2+ triggered by D-myo-inositol 1,4,5-trisphosphate (IP3), a PLC-beta hydrolysis product, or by measuring the production of inositol phosphate using cumbersome radioactive assays.", "entity1": "PLC-beta", "entity2": "D-myo-inositol 1,4,5-trisphosphate", "span1": [22, 30], "span2": [143, 177]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"1370": {"label": 0, "data": {"text": "These effects resemble those seen with N-terminal deletions (DeltaN) of K(IR)6.0, and application of Ntp to DeltaNK(ATP) channels decreased their P(O(max)) and apparent IC(50) for ATP in the absence of Mg(2+).", "entity1": "K(IR)6.0", "entity2": "N", "span1": [72, 80], "span2": [39, 40]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2442": {"label": 8, "data": {"text": "METHODS: Cyclooxygenase activity and selectivity was determined in vitro by measuring prostaglandin E(2) (PGE(2)) production following incubation of varying concentrations of NSAID with human recombinant COX-1 or COX-2 and arachidonic acid.", "entity1": "Cyclooxygenase", "entity2": "PGE(2)", "span1": [9, 23], "span2": [106, 112]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"9049": {"label": 1, "data": {"text": "In vitro binding affinities of chlorpromazine, fluphenazine, levomepromazine, perphenazine and some of their metabolites for dopamine D2 receptors, alpha 1- and alpha 2 adrenoceptors in rat brain were previously reported from our laboratories.", "entity1": "dopamine D2 receptors", "entity2": "fluphenazine", "span1": [125, 146], "span2": [47, 59]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7503": {"label": 1, "data": {"text": "Additional pharmacological effects evoked by AICAR and phenformin on I(ouabain), with potential secondary effects on apical Na+ conductance, ENaC activity and monolayer resistance, have important consequences for their use as pharmacological activators of AMPK in cell systems where Na+K+ATPase is an important component.", "entity1": "Na+K+ATPase", "entity2": "phenformin", "span1": [283, 294], "span2": [55, 65]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14075": {"label": 3, "data": {"text": "SB203580 (a specific inhibitor of p38 kinase) markedly suppressed the increased expression of collagen type I and \u03b1-SMA in TGF-\u03b21-induced NPDFs.", "entity1": "collagen type I", "entity2": "SB203580", "span1": [94, 109], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1275": {"label": 7, "data": {"text": "In this review we aim to provide an outline of the various ways in which BH4 affects NOS catalysis.", "entity1": "NOS", "entity2": "BH4", "span1": [85, 88], "span2": [73, 76]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"8106": {"label": 3, "data": {"text": "The mechanism revealed that wogonin inhibited H2O2-induced phosphorylation of caveolin-1 (cav-1) associating with the suppression of stabilization of VE-cadherin and \u03b2-catenin.", "entity1": "VE-cadherin", "entity2": "wogonin", "span1": [150, 161], "span2": [28, 35]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15393": {"label": 9, "data": {"text": "Here, we provide evidence that p14ARF physically interacts with AR and functions as an AR corespressor in both an androgen-dependent and androgen-independent manner.", "entity1": "AR", "entity2": "androgen", "span1": [87, 89], "span2": [137, 145]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7267": {"label": 3, "data": {"text": "DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.", "entity1": "human secretory isoform VI", "entity2": "sulfamate", "span1": [61, 87], "span2": [122, 131]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2493": {"label": 3, "data": {"text": "Licofelone, a balanced inhibitor of cyclooxygenase and 5-lipoxygenase, reduces inflammation in a rabbit model of atherosclerosis.", "entity1": "5-lipoxygenase", "entity2": "Licofelone", "span1": [55, 69], "span2": [0, 10]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10811": {"label": 3, "data": {"text": "As expected, comparison of IC50 indicated that meloxicam and carprofen are more selective inhibitors of COX-2 than phenylbutazone and flunixin; meloxicam was the most advantageous for horses of four NSAIDs examined.", "entity1": "COX-2", "entity2": "meloxicam", "span1": [104, 109], "span2": [47, 56]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12230": {"label": 8, "data": {"text": "The kinetic parameters for the CO2 hydration reaction proved hCA VI to possess a kcat of 3.4 x 10(5) s-1 and kcat/KM of 4.9 x 10(7) M-1 s-1 (at pH 7.5 and 20 degrees C).", "entity1": "hCA VI", "entity2": "CO2", "span1": [61, 67], "span2": [31, 34]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2174": {"label": 3, "data": {"text": "We used mutagenesis of these residues, combined with an investigation of hERG block by close analogs of clofilium and ibutilide, to assess how specific alterations in drug structure affected potency and binding interactions.", "entity1": "hERG", "entity2": "clofilium", "span1": [73, 77], "span2": [104, 113]}, "weak_labels": [-1, -1, -1, 1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6681": {"label": 5, "data": {"text": "Rats received a concomitant treatment with the selective beta(1)-adrenoceptor antagonist, bisoprolol (50 mg/kg/day p.o.)", "entity1": "beta(1)-adrenoceptor", "entity2": "bisoprolol", "span1": [57, 77], "span2": [90, 100]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15298": {"label": 3, "data": {"text": "The most potent compound 5 (HJC0123) has demonstrated to inhibit STAT3 promoter activity, downregulate phosphorylation of STAT3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar IC50 values.", "entity1": "STAT3 promoter", "entity2": "HJC0123", "span1": [65, 79], "span2": [28, 35]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4075": {"label": 8, "data": {"text": "During early pregnancy in sheep, the elongating conceptus secretes interferon-\u03c4 (IFNT) and the conceptus as well as endometrial epithelia produce prostaglandins (PG) via PG synthase 2 (PTGS2) and cortisol via hydroxysteroid (11-\u03b2) dehydrogenase 1 (HSD11B1).", "entity1": "HSD11B1", "entity2": "cortisol", "span1": [248, 255], "span2": [196, 204]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"8634": {"label": 2, "data": {"text": "In contrast, activation of Nrf2 by sulforaphane and tert-butylhydroquinone depend upon Keap1-C151 and not p62 (the canonical mechanism).", "entity1": "Nrf2", "entity2": "sulforaphane", "span1": [27, 31], "span2": [35, 47]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"2258": {"label": 1, "data": {"text": "Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor.", "entity1": "nuclear pregnane X receptor", "entity2": "rifampicin", "span1": [93, 120], "span2": [9, 19]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1361": {"label": 1, "data": {"text": "A series of mazindol (2) and homomazindol (3) analogues with a variety of electron-donating and electron-withdrawing groups in the pendant aryl group and the benzo ring C, as well as H, methoxy, and alkyl groups replacing the hydroxyl group were synthesized, and their binding affinities at the dopamine transporter (DAT) on rat or guinea pig striatal membranes were determined.", "entity1": "DAT", "entity2": "homomazindol", "span1": [317, 320], "span2": [29, 41]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"2394": {"label": 0, "data": {"text": "Interestingly, deletion of the entire yeast mitochondrial LeuRS C-terminal domain enhanced its aminoacylation and amino acid editing activities.", "entity1": "yeast mitochondrial LeuRS", "entity2": "amino acid", "span1": [38, 63], "span2": [114, 124]}, "weak_labels": [0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10558": {"label": 3, "data": {"text": "The persistent membrane retention of desipramine causes lasting inhibition of norepinephrine transporter function.", "entity1": "norepinephrine transporter", "entity2": "desipramine", "span1": [78, 104], "span2": [37, 48]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"11421": {"label": 8, "data": {"text": "Beta-1,4-galactosyltransferase I (beta4Gal-T1) normally transfers Gal from UDP-Gal to GlcNAc in the presence of Mn(2+) ion (Gal-T activity) and also transfers Glc from UDP-Glc to GlcNAc (Glc-T activity), albeit at only 0.3% efficiency.", "entity1": "Beta-1,4-galactosyltransferase I", "entity2": "UDP-Gal", "span1": [0, 32], "span2": [75, 82]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3612": {"label": 1, "data": {"text": "SB365, Pulsatilla saponin D suppresses the proliferation of human colon cancer cells and induces apoptosis by modulating the AKT/mTOR signalling pathway.", "entity1": "mTOR", "entity2": "Pulsatilla saponin D", "span1": [129, 133], "span2": [7, 27]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7691": {"label": 1, "data": {"text": "A PKC or MAP kinase inhibitor blocked the inhibitory effect of fenoldopam on insulin receptor expression, indicating that PKC and MAP kinase were involved in the signaling pathway.", "entity1": "PKC", "entity2": "fenoldopam", "span1": [122, 125], "span2": [63, 73]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"16012": {"label": 2, "data": {"text": "In addition, during acute exposure tests performed at the end of the chronic exposure, biofilms chronically exposed to 75 and 150\u03bcgL(-1) oxyfluorfen showed a higher CAT activity than controls.", "entity1": "CAT", "entity2": "oxyfluorfen", "span1": [165, 168], "span2": [137, 148]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8564": {"label": 2, "data": {"text": "Under NaCl and sorbitol stresses, catalase (CAT) activity in wnk8 mutant was 1.92- and 3.7-times of that in Col-0, respectively.", "entity1": "CAT", "entity2": "NaCl", "span1": [44, 47], "span2": [6, 10]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5590": {"label": 8, "data": {"text": "5-FU interferes with DNA synthesis by blocking thymidylate synthase (TS) but is inactivated by dihydropyrimidine dehydrogenase (DPD).", "entity1": "dihydropyrimidine dehydrogenase", "entity2": "5-FU", "span1": [95, 126], "span2": [0, 4]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15473": {"label": 3, "data": {"text": "Synthesis and evaluation of 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines as Bcl-2 inhibitory anticancer agents.", "entity1": "Bcl-2", "entity2": "3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines", "span1": [87, 92], "span2": [28, 83]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15338": {"label": 3, "data": {"text": "Coumarin 7-hydroxylation, catalyzed by P450 2A13, was strongly inhibited by 2'-methoxy-5,7-dihydroxyflavone, 2-ethynylnaphthalene, 2'-methoxyflavone, 2-naphththalene propargyl ether, acenaphthene, acenaphthylene, naphthalene, 1-acetylpyrene, flavanone, chrysin, 3-ethynylphenanthrene, flavone, and 7-hydroxyflavone; these chemicals induced Type I spectral changes with low Ks values.", "entity1": "P450 2A13", "entity2": "2'-methoxy-5,7-dihydroxyflavone", "span1": [39, 48], "span2": [76, 107]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"11331": {"label": 1, "data": {"text": "OBJECTIVE: To examine the influence of carvedilol dose and concentration in serum on plasma brain natriuretic peptide (BNP), a measure of heart failure progression.", "entity1": "brain natriuretic peptide", "entity2": "carvedilol", "span1": [92, 117], "span2": [39, 49]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"174": {"label": 5, "data": {"text": "The most potent compound, D,L-4-(3,4-dichlorobenzoylamino)-5-(dipentylamino)-5-oxo-pen tanoic acid (lorglumide, CR 1409), has a great affinity for the pancreatic CCK receptors and is a competitive, specific and potent CCK antagonist on the smooth muscles of the gall bladder and ileum of the guinea pig and on the CCK-induced amylase secretion of isolated pancreatic acini.", "entity1": "CCK", "entity2": "D,L-4-(3,4-dichlorobenzoylamino)-5-(dipentylamino)-5-oxo-pen tanoic acid", "span1": [218, 221], "span2": [26, 98]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14146": {"label": 1, "data": {"text": "In rat striatum and nucleus accumbens, mianserin stimulated [35S]GTPgammaS binding in a nor-BNI-sensitive manner with maximal effects lower than those of the full kappa-opioid agonists (-)-U50,488 and dynorphin A.", "entity1": "kappa-opioid", "entity2": "nor-BNI", "span1": [163, 175], "span2": [88, 95]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15615": {"label": 3, "data": {"text": "Galangin decreased expression of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-\u03b1, interleukin (IL)-6, IL-1\u03b2, and IL-8.", "entity1": "cytokines", "entity2": "Galangin", "span1": [50, 59], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7284": {"label": 3, "data": {"text": "This reduction in TGF-beta2 is biologically relevant since PFD treatment reduces the growth inhibition of TGF-beta-sensitive CCL-64 cells mediated by conditioned media of glioma cells.", "entity1": "TGF-beta", "entity2": "PFD", "span1": [106, 114], "span2": [59, 62]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15406": {"label": 1, "data": {"text": "This study evaluates the production of inflammatory biomarkers (IL-1\u03b2, IL-8, IL-10, TNF\u03b1) and the influence of gene expression transporters and enzymes related to cholesterol absorption and metabolism (NPC1L1, ABCG5/8, HMGCoA, ACAT) produced by 7-ketosterols (stigmasterol/cholesterol) in Caco-2 cells.", "entity1": "ACAT", "entity2": "7-ketosterols", "span1": [227, 231], "span2": [245, 258]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, 8, -1, -1]},
+	"1724": {"label": 3, "data": {"text": "Ginseng total saponins, ginsenosides Rb2, Rg1 and Rd administered intraperitoneally attenuated the immobilization stress-induced increase in plasma IL-6 level.", "entity1": "IL-6", "entity2": "saponins", "span1": [148, 152], "span2": [14, 22]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3474": {"label": 3, "data": {"text": "The anti-hyperthermic effect of Lu AF21934 (5 mg/kg) in the SIH test was inhibited by the benzodiazepine receptor antagonist flumazenil (10 mg/kg) and was not serotonin-dependent, as it persisted in serotonin-deficient mice and upon blockade of either 5-HT(1A) receptors by WAY100635, or 5-HT(2A/2C) receptors by ritanserin.", "entity1": "5-HT(2A/2C)", "entity2": "ritanserin", "span1": [288, 299], "span2": [313, 323]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"6920": {"label": 9, "data": {"text": "Furthermore, HM74A, but not HM74, expressed in differentiated 3T3L1 adipocytes effectively mediated inhibition of lipolysis by niacin.", "entity1": "HM74", "entity2": "niacin", "span1": [28, 32], "span2": [127, 133]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"2972": {"label": 1, "data": {"text": "Change in affinity for cGMP, vardenafil, sildenafil, or IBMX in Y612F, H613A, L765A, or F786A was less, but affinity of H613A or F786A for tadalafil was weakened 37- and 17-fold, respectively.", "entity1": "L765A", "entity2": "sildenafil", "span1": [78, 83], "span2": [41, 51]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13885": {"label": 3, "data": {"text": "Activation of PPARgamma with traditional agonists mimics the RhoA-inhibiting properties of ibuprofen in PC12 cells and, like ibuprofen, promotes neurite elongation in primary cultured neurons exposed to axonal growth inhibitors.", "entity1": "RhoA", "entity2": "ibuprofen", "span1": [61, 65], "span2": [91, 100]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11780": {"label": 3, "data": {"text": "There was no significant difference in TLR4, NF-\u03baB, and IL-27 mRNA and proteins between curcumin-treated and sulfasalazine-treated groups.", "entity1": "IL-27", "entity2": "curcumin", "span1": [56, 61], "span2": [88, 96]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6485": {"label": 4, "data": {"text": "CONCLUSIONS: The alpha(2)-adrenoceptor agonists brimonidine, apraclonidine, and oxymetazoline are potent vasoconstrictors in the porcine ciliary artery.", "entity1": "alpha(2)-adrenoceptor", "entity2": "oxymetazoline", "span1": [17, 38], "span2": [80, 93]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14107": {"label": 1, "data": {"text": "Our biophysical, biochemical and gene silencing studies show that CRBN is a proximate, therapeutically important molecular target of lenalidomide and pomalidomide.", "entity1": "CRBN", "entity2": "pomalidomide", "span1": [66, 70], "span2": [150, 162]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5147": {"label": 0, "data": {"text": "Here we report the solution structure of the SH2 domain of CC-terminal Src kinase (Csk) in complex with a longer phosphopeptide from Csk-binding protein (Cbp).", "entity1": "C-terminal Src kinase", "entity2": "C", "span1": [60, 81], "span2": [59, 60]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14969": {"label": 3, "data": {"text": "The peptide YR-11 (YLEIEFSLKHR), obtained by direct substitution of cysteine with a serine residue in the template sequence, significantly (p<0.05) inhibited RANK-RANKL binding, and RANKL induced TRAP activity and formation of multinucleated osteoclasts without any cytotoxicity.", "entity1": "RANKL", "entity2": "cysteine", "span1": [182, 187], "span2": [68, 76]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1328": {"label": 1, "data": {"text": "Angiotensin II receptor antagonists block angiotensin II type 1 (AT1) receptors and reduce the pressor effects of angiotensin in the vasculature.", "entity1": "angiotensin II type 1 (AT1) receptors", "entity2": "angiotensin", "span1": [42, 79], "span2": [114, 125]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7188": {"label": 3, "data": {"text": "CONCLUSION: Intake of high SFAs and MUFAs appears to increase expression of PBMC D6D and D5D genes, whilst high EFAs intake appears to decrease expression of PBMC D6D and D5D genes.", "entity1": "D6D", "entity2": "EFAs", "span1": [163, 166], "span2": [112, 116]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9029": {"label": 1, "data": {"text": "Beta 2-Adrenoceptor density, however, declined slowly being still significantly increased after 3 days, although propranolol was not detectable in plasma after 24 h. The affinity of ICYP to beta 2-adrenoceptors was not changed during or after treatment.", "entity1": "beta 2-adrenoceptors", "entity2": "ICYP", "span1": [190, 210], "span2": [182, 186]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"12667": {"label": 8, "data": {"text": "Accordingly, self-administration of a group of local anesthetics that are DAT ligands was compared to their effects as DA uptake blockers in vitro in brain tissue.", "entity1": "DAT", "entity2": "DA", "span1": [74, 77], "span2": [119, 121]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15196": {"label": 3, "data": {"text": "In another experiment, topical application of CFB, CFE or CLS prior to UVB irradiation (200mJ/cm(2)) on BALB/c mice, inhibited the UVB-elevated protein levels of COX-2, iNOS, and TNF-\u03b1.", "entity1": "COX-2", "entity2": "CLS", "span1": [162, 167], "span2": [58, 61]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"11083": {"label": 1, "data": {"text": "We have examined the effects on the activities of three calmodulin-dependent enzymes (cAMP phosphodiesterase, caldesmon kinase and myosin light chain kinase) of the dihydropyridine Ca2+ channel blocker felodipine and three analogues (p-chloro, oxidized and t-butyl) exhibiting different pharmacological potencies.", "entity1": "calmodulin-dependent enzymes", "entity2": "dihydropyridine", "span1": [56, 84], "span2": [165, 180]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15754": {"label": 3, "data": {"text": "Ethanol-stimulated (100mM) CYP2E1 upregulation was suppressed by quercetin but further enhanced by HO-1 inhibition with resultant heme accumulation.", "entity1": "CYP2E1", "entity2": "quercetin", "span1": [27, 33], "span2": [65, 74]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9026": {"label": 2, "data": {"text": "We conclude that androgens can stimulate human and murine osteoblastic cell proliferation in vitro, and induce expression of the osteoblast-line differentiation marker ALP, presumably by an androgen receptor mediated mechanism.", "entity1": "ALP", "entity2": "androgens", "span1": [168, 171], "span2": [17, 26]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13191": {"label": 1, "data": {"text": "2beta-carbomethoxy-3beta-(3'-((Z)-2-iodoethenyl)phenyl)nortropane (mZIENT, 1) and 2beta-carbomethoxy-3beta-(3'-((Z)-2-bromoethenyl)phenyl)nortropane (mZBrENT, 2) were synthesized and evaluated for binding to the human serotonin, dopamine, and norepinephrine transporters (SERT, DAT, and NET, respectively) using transfected cells.", "entity1": "NET", "entity2": "mZBrENT", "span1": [287, 290], "span2": [150, 157]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"9789": {"label": 5, "data": {"text": "The sigma-receptor antagonist rimcazole (3 mg/kg, i.p.)", "entity1": "sigma-receptor", "entity2": "rimcazole", "span1": [4, 18], "span2": [30, 39]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13390": {"label": 2, "data": {"text": "In summary, phenformin and metformin increase AMPK activity and phosphorylation in the isolated heart.", "entity1": "AMPK", "entity2": "phenformin", "span1": [46, 50], "span2": [12, 22]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4813": {"label": 3, "data": {"text": "A new series of N2-substituted-5-(p-toluenesulfonylamino)phthalimide analogues as \u03b1-glucosidase inhibitors.", "entity1": "\u03b1-glucosidase", "entity2": "N2-substituted-5-(p-toluenesulfonylamino)phthalimide", "span1": [82, 95], "span2": [16, 68]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2073": {"label": 1, "data": {"text": "The effect of gemcitabine and pemetrexed on Akt phosphorylation was investigated with enzyme-linked immunosorbent assay, whereas quantitative polymerase chain reaction (PCR) was used to study target gene-expression profiles and its modulation by each drug.", "entity1": "Akt", "entity2": "gemcitabine", "span1": [44, 47], "span2": [14, 25]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15924": {"label": 1, "data": {"text": "In mature lung tissue of healthy donors, polySia was exclusively attached to the transmembrane isoform NCAM-140 and located to intracellular compartments of epithelial cells.", "entity1": "NCAM-140", "entity2": "polySia", "span1": [103, 111], "span2": [41, 48]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2242": {"label": 3, "data": {"text": "Dasatinib (BMS-354825) is a novel orally bioavailable SRC/ABL inhibitor that has activity against multiple imatinib-resistant BCR-ABL isoforms in vitro that is presently showing considerable promise in early-phase clinical trials of chronic myeloid leukemia (CML).", "entity1": "SRC", "entity2": "BMS-354825", "span1": [54, 57], "span2": [11, 21]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14673": {"label": 3, "data": {"text": "Genistein also reduced the formation of stress fibers by thrombin and suppressed thrombin-induced phosphorylation of myosin light chain (MLC) on Ser(19)/Thr(18) in endothelial cells (ECs).", "entity1": "thrombin", "entity2": "Genistein", "span1": [57, 65], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9742": {"label": 1, "data": {"text": "Herein, we evaluate the interaction of the alpha(2)-AR antagonist, yohimbine, as compared to fluparoxan, at multiple monoaminergic receptors and examine their roles in the modulation of adrenergic, dopaminergic and serotonergic transmission in freely-moving rats.", "entity1": "monoaminergic receptors", "entity2": "fluparoxan", "span1": [117, 140], "span2": [93, 103]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8908": {"label": 3, "data": {"text": "We now demonstrate that amrinone, a noncatechol inotrope, strongly inhibits lipopolysaccharide (LPS)-induced TNF production at concentrations readily achieved in vivo.", "entity1": "TNF", "entity2": "amrinone", "span1": [109, 112], "span2": [24, 32]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, 9]},
+	"11407": {"label": 2, "data": {"text": "Treatment with carvedilol reversed both protein and mRNA of HIF-1alpha, VEGF, BNP, and NGF-beta to the baseline values.", "entity1": "NGF-beta", "entity2": "carvedilol", "span1": [87, 95], "span2": [15, 25]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9510": {"label": 1, "data": {"text": "Saturation and competition studies in the presence or absence of the histamine H1 receptor antagonist, levocabastine, revealed that [3H]SR 142948A bound with similar affinities to both the levocabastine-insensitive neurotensin NT1 receptors (20% of the total binding population) and the recently cloned levocabastine-sensitive neurotensin NT2 receptors (80% of the receptors) (Kd = 6.8 and 4.8 nM, respectively).", "entity1": "neurotensin NT2 receptors", "entity2": "levocabastine", "span1": [327, 352], "span2": [303, 316]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15594": {"label": 4, "data": {"text": "Oral lorcaserin (BELVIQ(\u00ae)), a selective serotonin 5-HT2C receptor agonist, is indicated in the US as an adjunct to diet and exercise in the chronic weight management of obese adults, or overweight adults with at least one weight-related comorbidity (e.g.", "entity1": "5-HT2C", "entity2": "BELVIQ", "span1": [51, 57], "span2": [17, 23]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1731": {"label": 1, "data": {"text": "Agonist competition assays with [3H]DHA showed the following rank order of potency: isoproterenol>epinephrine> norepinephrine, consistent with beta2AR interaction.", "entity1": "beta2AR", "entity2": "isoproterenol", "span1": [143, 150], "span2": [84, 97]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"215": {"label": 5, "data": {"text": "Alprenolol and BAAM also caused surmountable antagonism of isoprenaline responses, and this beta 1-adrenoceptor antagonism was slowly reversible.", "entity1": "beta 1-adrenoceptor", "entity2": "BAAM", "span1": [92, 111], "span2": [15, 19]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5217": {"label": 2, "data": {"text": "In addition, vinblastine induces the DNA-binding activities of the transcription factor NF-\u03baB, HSF1, AP-1, and ATF-2, together with the expression of HSP70 and Bax proteins.", "entity1": "AP-1", "entity2": "vinblastine", "span1": [101, 105], "span2": [13, 24]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15197": {"label": 3, "data": {"text": "In another experiment, topical application of CFB, CFE or CLS prior to UVB irradiation (200mJ/cm(2)) on BALB/c mice, inhibited the UVB-elevated protein levels of COX-2, iNOS, and TNF-\u03b1.", "entity1": "iNOS", "entity2": "CLS", "span1": [169, 173], "span2": [58, 61]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"12012": {"label": 1, "data": {"text": "We investigated the diurnal expression of clock genes and clock-controlled genes (CCGs) in 3-hour intervals for a 24-h period in the livers of male streptozotocin (STZ)-treated rats, male spontaneous type 1 diabetic LEW.1AR1-iddm (Iddm) rats, and Iddm rats treated for 10 days with insulin.", "entity1": "clock-controlled genes", "entity2": "streptozotocin", "span1": [58, 80], "span2": [148, 162]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10318": {"label": 1, "data": {"text": "Results indicate that imiquimod and resiquimod induce IFN-alpha and IFN-omega from purified pDC, and pDC are the principle IFN-producing cells in the blood.", "entity1": "IFN", "entity2": "resiquimod", "span1": [123, 126], "span2": [36, 46]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"15786": {"label": 8, "data": {"text": "A series of aminopropylindenes, designed as mimics of a cationic high energy intermediate in the oxidosqualene cyclase(1) (OSC)-mediated cyclization of 2,3-oxidosqualen to lanosterol was prepared from Grundmann's ketone.", "entity1": "oxidosqualene cyclase(1)", "entity2": "2,3-oxidosqualen", "span1": [97, 121], "span2": [152, 168]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11903": {"label": 3, "data": {"text": "Western blotting demonstrated that DMBT effectively suppressed the expression of VEGF, p-VEGFR-2, p-EGFR, and p-Akt.", "entity1": "p-EGFR", "entity2": "DMBT", "span1": [98, 104], "span2": [35, 39]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6590": {"label": 1, "data": {"text": "These results indicate that quetiapine, iloperidone and melperone preferentially increase DA release in the mPFC, compared to the NAC via a 5-HT(1A)-related mechanism.", "entity1": "5-HT(1A)", "entity2": "iloperidone", "span1": [140, 148], "span2": [40, 51]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4693": {"label": 2, "data": {"text": "Upon co-exposure to V(5+) and TCDD, V(5+) significantly potentiated the TCDD-mediated induction of the Cyp1a1, Cyp1a2, and Cyp1b1 mRNA, protein, and catalytic activity levels at 24\u00a0h. In vitro, V(5+) decreased the TCDD-mediated induction of Cyp1a1 mRNA, protein, and catalytic activity levels.", "entity1": "Cyp1a1", "entity2": "V(5+)", "span1": [103, 109], "span2": [36, 41]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11374": {"label": 9, "data": {"text": "Only five tumors failed to express TP but four of these expressed DPD, suggesting capecitabine resistance.", "entity1": "DPD", "entity2": "capecitabine", "span1": [66, 69], "span2": [82, 94]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15792": {"label": 2, "data": {"text": "MRS2179, a P2Y1R blocker, prevented potentiation in EDL, but not soleus muscles, suggesting that in fast muscles ATP activates P2Y1 but not P2X receptors.", "entity1": "P2Y1", "entity2": "ATP", "span1": [127, 131], "span2": [113, 116]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"5115": {"label": 2, "data": {"text": "Further, 5HHMF increased specific DNA-binding activity of Nrf2, and transient knockdown with Nrf2 siRNA subsequently reversed 5HHMF-induced NO inhibition, which was followed by suppression of HO-1 activity.", "entity1": "Nrf2", "entity2": "5HHMF", "span1": [93, 97], "span2": [126, 131]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, 2, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4008": {"label": 3, "data": {"text": "Compared with the untreated colitis group, the curcumin-treated group showed significant decreases in the disease activity index, colonic mucosa damage index, histological score, myeloperoxidase activity, and expressions of NF-\u03baB mRNA, IL-27 mRNA, TLR4 protein, NF-\u03baB p65 protein, and IL-27 p28 protein (p < 0.05).", "entity1": "NF-\u03baB", "entity2": "curcumin", "span1": [224, 229], "span2": [47, 55]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14317": {"label": 1, "data": {"text": "However, downregulation of the antioxidant response element (ARE)-driven Nrf2 target genes such as NQO1, HO-1 and glutathione S-transferase (GST) did not reverse the inhibitory effect of DMF on TGF-beta-induced upregulation of profibrotic genes or extracellular matrix proteins, suggesting an ARE-independent anti-fibrotic activity of DMF.", "entity1": "Nrf2", "entity2": "DMF", "span1": [73, 77], "span2": [187, 190]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, 2, 3, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"759": {"label": 1, "data": {"text": "Finally, mutations of the thiazidethiazide-sensitive sodium-chloride cotransporter (NCCT) are associated with Gitelman's syndrome.", "entity1": "thiazide-sensitive sodium-chloride cotransporter", "entity2": "thiazide", "span1": [34, 82], "span2": [26, 34]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"3192": {"label": 3, "data": {"text": "Phenols like the ones investigated here possess a CA inhibition mechanism distinct of that of the sulfonamides/sulfamates used clinically or the coumarins.", "entity1": "CA", "entity2": "Phenols", "span1": [50, 52], "span2": [0, 7]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9343": {"label": 5, "data": {"text": "Kainate-evoked currents showed partial desensitization that was reduced on incubation with concanavalin A (conA) but not cyclothiazide and were attenuated by the non-N-methyl-D-aspartate (NMDA) receptor antagonist CNQX (6-cyano-7-nitro-quinoxalinedione).", "entity1": "N-methyl-D-aspartate (NMDA) receptor", "entity2": "CNQX", "span1": [166, 202], "span2": [214, 218]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"11814": {"label": 8, "data": {"text": "The mouse CYP2J subfamily includes members that have wide tissue distribution and are active in the metabolism of arachidonic acid (AA), linoleic acid (LA), and other lipids and xenobiotics.", "entity1": "CYP2J", "entity2": "linoleic acid", "span1": [10, 15], "span2": [137, 150]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13960": {"label": 3, "data": {"text": "However, both compounds have similar molecular mechanisms of neuroprotection in neuronal cell cultures and animal neurodegenerative models, indicating that the neuroprotective effect of rasagiline does not depend on inhibition of MAO-B, but rather is associated with the N-propargyl moiety, which promotes mitochondrial viability and stabilizes permeability transition by regulating Bcl-2 family proteins.", "entity1": "MAO-B", "entity2": "rasagiline", "span1": [230, 235], "span2": [186, 196]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"6315": {"label": 8, "data": {"text": "We found that 5-HT stimulated the conversion of [3H]L-arginine ([3H]L-Arg) to [3H]L-Cit, indicating eNOS activation.", "entity1": "eNOS", "entity2": "[3H]L-arginine", "span1": [100, 104], "span2": [48, 62]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1]},
+	"10292": {"label": 1, "data": {"text": "These differences from the horse might be the result of: (a) the presence in equine biological fluids of higher concentrations than in calves of the active PBZ metabolite, OPBZ; (b) a greater degree of binding of PBZ to plasma protein in calves; (c) species differences in the sensitivity to PBZ of the cyclo-oxygenase (COX) isoenzymes, COX-1 and COX-2 or; (d) a combination of these factors.", "entity1": "COX-2", "entity2": "PBZ", "span1": [347, 352], "span2": [292, 295]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12665": {"label": 1, "data": {"text": "Various drugs used in the treatment of IBD, such as glucocorticoids, 5-aminosalicylic acid, and sulfasalazine, interfere with NF-kappaB/Rel signaling.", "entity1": "NF-kappaB", "entity2": "sulfasalazine", "span1": [126, 135], "span2": [96, 109]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14714": {"label": 3, "data": {"text": "Furthermore, insulin-stimulated T-I cell proliferation and the expression of cell cycle regulatory proteins CDK4, CCND3 and PCNA were also blocked by rapamycin.", "entity1": "CCND3", "entity2": "rapamycin", "span1": [114, 119], "span2": [150, 159]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6697": {"label": 3, "data": {"text": "Known VR1 antagonists (BCTC, thio-BCTC and capsazepine) were also able to block the response of TRPM8 to menthol (IC(50): 0.8+/-1.0, 3.5+/-1.1 and 18+/-1.1 microM, respectively).", "entity1": "TRPM8", "entity2": "capsazepine", "span1": [96, 101], "span2": [43, 54]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3444": {"label": 5, "data": {"text": "Differentiating the roles of mGlu2 and mGlu3 receptors using LY541850, an mGlu2 agonist/mGlu3 antagonist.", "entity1": "mGlu3", "entity2": "LY541850", "span1": [88, 93], "span2": [61, 69]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7705": {"label": 2, "data": {"text": "atropine, AChE reactivator such as one of the recommended pyridinium oximes (pralidoxime, trimedoxime, obidoxime and HI-6) and diazepam are used for the treatment of OP poisoning in humans.", "entity1": "AChE", "entity2": "pyridinium oximes", "span1": [10, 14], "span2": [58, 75]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6523": {"label": 3, "data": {"text": "Angiotensin II suppression in humans by the orally active renin inhibitor Aliskiren (SPP100): comparison with enalapril.", "entity1": "renin", "entity2": "SPP100", "span1": [58, 63], "span2": [85, 91]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7977": {"label": 3, "data": {"text": "Moreover, 1,25(OH)(2)D(3) decreased expression of Oat1 and Oat3 in rat kidney.", "entity1": "Oat3", "entity2": "1,25(OH)(2)D(3)", "span1": [59, 63], "span2": [10, 25]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10534": {"label": 1, "data": {"text": "The ability of this cis-acting RAR-RXR binding element to activate transcription in response to RA also depended on downstream sequences where an octamer transcription factor 1 (Oct1) site and a nuclear factor of activated T cells (NFATc) site between this element and the transcriptional start, as well as a cyclic AMP response element binding factor (CREB) site between the transcriptional start and first exon of the blr1 gene, were necessary.", "entity1": "nuclear factor of activated T cells", "entity2": "RA", "span1": [195, 230], "span2": [96, 98]}, "weak_labels": [-1, -1, -1, 1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11859": {"label": 8, "data": {"text": "The calcium homeostasis proteins sarcoendoplasmic reticulum ATPase 2a (SERCA2a), sodium calcium exchanger-1, phospholamban (PLB), phospho-PLB, and calsequestrin 2 are important for contraction and relaxation.", "entity1": "phospholamban", "entity2": "calcium", "span1": [109, 122], "span2": [4, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12923": {"label": 8, "data": {"text": "Here, we show that at noncytotoxic concentrations, H(2)S was able to inhibit NO production and inducible NO synthase (iNOS) expression via heme oxygenase (HO-1) expression in RAW264.7 macrophages stimulated with lipopolysaccharide (LPS).", "entity1": "iNOS", "entity2": "NO", "span1": [118, 122], "span2": [77, 79]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"6476": {"label": 3, "data": {"text": "Nordihydroguaiaretic acid (NDGA) has been shown to inhibit both 5-lipoxygenase and ornithine decarboxylase and is active against several cancer cell lines and at least one mouse tumor model.", "entity1": "5-lipoxygenase", "entity2": "NDGA", "span1": [64, 78], "span2": [27, 31]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10089": {"label": 3, "data": {"text": "Celecoxib selectively suppressed PGE2 but not TxB2 at time points consistent with COX-2 activity, while producing analgesia.", "entity1": "COX-2", "entity2": "Celecoxib", "span1": [82, 87], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, 9]},
+	"3432": {"label": 1, "data": {"text": "Epi increased the activity of the human WNT6 promoter through Cav1-dependent binding of \u03b2-catenin to the proximal WNT6 promoter.", "entity1": "\u03b2-catenin", "entity2": "Epi", "span1": [88, 97], "span2": [0, 3]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11473": {"label": 1, "data": {"text": "Melatonin and N-acetyl-5-hydroxytryptamine (N-acetyl-5-HT), a ligand of MT3 biding site, also had no impairment on the performance, per se.", "entity1": "MT3", "entity2": "N-acetyl-5-hydroxytryptamine", "span1": [72, 75], "span2": [14, 42]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7663": {"label": 1, "data": {"text": "Examining the four X-ray crystal structures of their CA II adducts, we observed several (2-3) active site water molecules interacting with the chlorthalidone, trichloromethiazide, and furosemide scaffolds which may be responsible for this important difference of activity.", "entity1": "CA II", "entity2": "chlorthalidone", "span1": [53, 58], "span2": [143, 157]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12842": {"label": 1, "data": {"text": "However, there were some significant differences among Captopril (30 mg/kg or 45 mg/kg), enalapril (20 mg/kg), and N-acetylcysteine particular in the activity of PON1 and ACE.", "entity1": "PON1", "entity2": "Captopril", "span1": [162, 166], "span2": [55, 64]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10736": {"label": 9, "data": {"text": "Using the reverse-transcription and real-time quantitative PCR (RQ-PCR) analysis, we indicated that AZC and PCA did not profoundly affect on CD3-zeta chain transcription in Jurkat T leukemia cells clone E6-1.", "entity1": "CD3-zeta chain", "entity2": "AZC", "span1": [141, 155], "span2": [100, 103]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"3869": {"label": 2, "data": {"text": "First, we showed that intracerebroventricular administration of glucose in rats increases DBI expression in hypothalamic glial-like tanycytes.", "entity1": "DBI", "entity2": "glucose", "span1": [90, 93], "span2": [64, 71]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4235": {"label": 1, "data": {"text": "Functional and biochemical studies indicated that TES signaling involved activity of the phosphoinositide 3 (PI3) kinase-protein kinase B (Akt) cascade initiated by activation of the androgen receptor and culminated in enhanced production of cGMP and microvascular vasodilation.", "entity1": "phosphoinositide 3 (PI3) kinase", "entity2": "TES", "span1": [89, 120], "span2": [50, 53]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"9400": {"label": 0, "data": {"text": "In Drosophila, glutamyl-prolyl-tRNA synthetase is a multifunctional synthetase encoded by a unique gene and composed of three domains: the amino- and carboxy-terminal domains catalyze the aminoacylation of glutamic acid and proline tRNA species, respectively, and the central domain is made of 75 amino acids repeated six times amongst which 46 are highly conserved and constitute the repeated motifs [Cerini, C., Kerjan, P., Astier, M., Gratecos, D., Mirande, M. & Semeriva, M. (1991) EMBO J.", "entity1": "glutamyl-prolyl-tRNA synthetase", "entity2": "amino acids", "span1": [15, 46], "span2": [297, 308]}, "weak_labels": [0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"6657": {"label": 3, "data": {"text": "Patients stable on warfarin therapy and concurrently taking a cyclooxygenase-2 (COX-2) inhibitor comparator (traditional nonsteroidal antiinflammatory medications, salsalate, or acetaminophen) randomly received celecoxib 200 mg/day or rofecoxib 25 mg/day for three weeks.", "entity1": "COX-2", "entity2": "salsalate", "span1": [80, 85], "span2": [164, 173]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12570": {"label": 9, "data": {"text": "Glutathione-independent prostaglandin D synthase [prostaglandin-H2 D-isomerase; (5Z,13E)-(15S)-9 alpha,11 alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase, EC 5.3.99.2] is an enzyme responsible for biosynthesis of prostaglandin D2 in the central nervous system.", "entity1": "prostaglandin D synthase", "entity2": "Glutathione", "span1": [24, 48], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4404": {"label": 0, "data": {"text": "Previous work has extensively characterized a common allosteric site on mGlu5, termed the MPEP (2-Methyl-6-(phenylethynyl)pyridine) binding site.", "entity1": "mGlu5", "entity2": "2-Methyl-6-(phenylethynyl)pyridine", "span1": [72, 77], "span2": [96, 130]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1]},
+	"2916": {"label": 3, "data": {"text": "The pharmacology of NCX inhibitors has been studied extensively since the development of KB-R7943, a prototype benzyloxyphenyl NCX inhibitor, in 1996.", "entity1": "NCX", "entity2": "benzyloxyphenyl", "span1": [127, 130], "span2": [111, 126]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10375": {"label": 3, "data": {"text": "This study shows that the potency of GW660511X in comparison with omapatrilat is more than 100-fold lower in human, but less than 10-fold lower in rat plasma, suggesting that rat may not be a suitable in vivo model for the evaluation of ACE/NEP inhibition in relation to effects in humans.", "entity1": "NEP", "entity2": "omapatrilat", "span1": [241, 244], "span2": [66, 77]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"7745": {"label": 3, "data": {"text": "PURPOSE: XL184 (cabozantinib) is a potent inhibitor of MET, vascular endothelial growth factor receptor 2 (VEGFR2), and RET, with robust antiangiogenic, antitumor, and anti-invasive effects in preclinical models.", "entity1": "vascular endothelial growth factor receptor 2", "entity2": "XL184", "span1": [60, 105], "span2": [9, 14]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8869": {"label": 2, "data": {"text": "I3S increased expression of ROR\u03b3t, the master transcription factor for Th17 differentiation, and stimulated Th17 differentiation, in a comparative manner as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a prototypical AhR ligand.", "entity1": "ROR\u03b3t", "entity2": "I3S", "span1": [28, 33], "span2": [0, 3]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5309": {"label": 0, "data": {"text": "Recombinant P2X3/CASK expression in HEK cells increased serine phosphorylation of P2X3 receptors, typically associated with receptor upregulation.", "entity1": "P2X3", "entity2": "serine", "span1": [82, 86], "span2": [56, 62]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2298": {"label": 5, "data": {"text": "Also consistent with the involvement of Gq coupled EP1 receptors, the PGE1 stimulation is inhibited by the PKCI vector (encoding the PKC inhibitory domain), the PKC inhibitor Go 6976, thapsigargin, as well as the calmodulin antagonists W7 and W13.", "entity1": "calmodulin", "entity2": "W7", "span1": [213, 223], "span2": [236, 238]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8745": {"label": 8, "data": {"text": "Using recombinant UGT2B10, we found that it catalyzes the N-glucuronidation of amitriptyline, imipramine, ketotifen, pizotifen, olanzapine, diphenhydramine, tamoxifen, ketoconazole and midazolam.", "entity1": "UGT2B10", "entity2": "diphenhydramine", "span1": [18, 25], "span2": [140, 155]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"10384": {"label": 3, "data": {"text": "Investigation of bradykinin metabolism in human and rat plasma in the presence of the dual ACE/NEP inhibitors GW660511X and omapatrilat.", "entity1": "ACE", "entity2": "omapatrilat", "span1": [91, 94], "span2": [124, 135]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"597": {"label": 1, "data": {"text": "The action of 15d-PGJ2 does not appear to involve its nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) because troglitazone, a specific ligand of PPARgamma, was unable to inhibit iNOS induction, and neither troglitazone nor 15d-PGJ2 could stimulate the activity of a PPAR-dependent promoter in the absence of cotransfected PPARgamma.", "entity1": "PPARgamma", "entity2": "troglitazone", "span1": [175, 184], "span2": [140, 152]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"15443": {"label": 8, "data": {"text": "When mice were treated ip with the major neonicotinoid imidacloprid (IMI), metabolism by CYP oxidation reactions was not appreciably affected, whereas the AOX-generated nitrosoguanidine metabolite was decreased by 30% with tungsten and 56% with hydralazine and 86% in the AOX-deficient mice.", "entity1": "AOX", "entity2": "nitrosoguanidine", "span1": [155, 158], "span2": [169, 185]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"7086": {"label": 3, "data": {"text": "We further show that menthol inhibits TRPA1, potentially explaining the use of menthol as an analgesic.", "entity1": "TRPA1", "entity2": "menthol", "span1": [38, 43], "span2": [21, 28]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10639": {"label": 3, "data": {"text": "Troglitazone, bosentan and glibenclamide inhibit the bile salt export pump (Bsep) which transports taurocholate into bile.", "entity1": "Bsep", "entity2": "glibenclamide", "span1": [76, 80], "span2": [27, 40]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"1114": {"label": 2, "data": {"text": "In view of the role of CA in acid-base balance as well as the fact that an increase or decrease in its activity is accompanied by an increase or decrease in intra- and extracellular pH, our results suggest that: firstly, CA activation induced by indomethacin might cause changes in COX activity; secondly, PGs are synthetized as a consequence of the changes in COX activity, a hypothesis that requires further study.", "entity1": "CA", "entity2": "indomethacin", "span1": [221, 223], "span2": [246, 258]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13962": {"label": 1, "data": {"text": "Consistent with the results of a computer analysis, the binding of R316C to triiodothyronine (T3) was significantly decreased to 38% that of the wild type.", "entity1": "R316C", "entity2": "T3", "span1": [67, 72], "span2": [94, 96]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9316": {"label": 3, "data": {"text": "The goal of the present study was to compare the effects of three potent reference renin inhibitors (remikiren, CGP 38560A, and enalkiren) in sodium-depleted normotensive squirrel monkeys.", "entity1": "renin", "entity2": "enalkiren", "span1": [83, 88], "span2": [128, 137]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14882": {"label": 1, "data": {"text": "Substantial evidence shows that H(2)S is involved in aging by inhibiting free-radical reactions, activating SIRT1, and probably interacting with the age-related gene Klotho.", "entity1": "Klotho", "entity2": "H(2)S", "span1": [166, 172], "span2": [32, 37]}, "weak_labels": [-1, -1, -1, -1, 1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14645": {"label": 8, "data": {"text": "Wild-type enzymes and variants of CDA (Lys27Gln and Ala70Thr) and DCK (Ile24Val, Ala119Gly, and Pro122Ser) were expressed in and purified from Escherichia coli, and enzyme kinetic parameters were estimated for cytarabine (Ara-C), dFdC, and its metabolite 2',2'-difluorodeoxyuridine (dFdU) as substrates.", "entity1": "CDA", "entity2": "cytarabine", "span1": [34, 37], "span2": [210, 220]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"3885": {"label": 0, "data": {"text": "A structure-activity relationship (SAR) study of the c-Myc (Myc) inhibitor 10074-G5 (N-([1,1'-biphenyl]-2-yl)-7-nitrobenzo[c][1,2,5]oxadiazol-4-amine, 1) - which targets a hydrophobic domain of the Myc oncoprotein that is flanked by arginine residues - was executed in order to determine its pharmacophore.", "entity1": "Myc", "entity2": "arginine", "span1": [198, 201], "span2": [233, 241]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6499": {"label": 5, "data": {"text": "The following alpha(2)-adrenoceptor antagonists were applied: BRL44408 (alpha(2A)-selective), ARC239 (alpha(2B)- and alpha(2C)-selective), and prazosin (alpha(2B)- and alpha(2C)-selective).", "entity1": "alpha(2C)", "entity2": "prazosin", "span1": [168, 177], "span2": [143, 151]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14463": {"label": 1, "data": {"text": "The [(3)H]PGE(2) binding of W203A in broken cell membrane fractions was inhibited by addition of GTP\u03b3S (IC(50) 21 \u00b1 1.8 nM).", "entity1": "W203A", "entity2": "GTP\u03b3S", "span1": [28, 33], "span2": [97, 102]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14426": {"label": 3, "data": {"text": "Metformin treatment is also associated with lower circulating levels of the orexigenic hormone ghrelin.", "entity1": "ghrelin", "entity2": "Metformin", "span1": [95, 102], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12021": {"label": 1, "data": {"text": "Using electrophysiologic techniques, the present study assessed the in vivo action of brexpiprazole on serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT1B, and 5-HT2A; dopamine (DA) D2 autoreceptors, and alpha1- and alpha2-adrenergic receptors.", "entity1": "5-HT1B", "entity2": "brexpiprazole", "span1": [146, 152], "span2": [86, 99]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4597": {"label": 3, "data": {"text": "Novel N-indolylmethyl substituted spiroindoline-3,2'-quinazolines were designed as potential inhibitiors of SIRT1.", "entity1": "SIRT1", "entity2": "N-indolylmethyl substituted spiroindoline-3,2'-quinazolines", "span1": [108, 113], "span2": [6, 65]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10320": {"label": 2, "data": {"text": "The immune response modifiers, imiquimod and resiquimod, are TLR7 agonists that induce type I interferon in numerous species, including humans.", "entity1": "type I interferon", "entity2": "imiquimod", "span1": [87, 104], "span2": [31, 40]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9132": {"label": 1, "data": {"text": "In addition, phenoxybenzamine showed little or no calcium-dependent binding to the S-100 protein, bovine serum albumin or cytochrome c. The irreversible complex between phenoxybenzamine and calmodulin may be useful for inhibiting certain calmodulin-dependent reactions and for studying the various biological functions of calmodulin.", "entity1": "bovine serum albumin", "entity2": "calcium", "span1": [98, 118], "span2": [50, 57]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5581": {"label": 8, "data": {"text": "PURPOSE: The fluoropyrimidine carbamate (capecitabine) is converted to 5-fluorouracil (5-FU) by thymidine phosphorylase (TP) inside target tissues.", "entity1": "thymidine phosphorylase", "entity2": "capecitabine", "span1": [96, 119], "span2": [41, 53]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1]},
+	"15374": {"label": 2, "data": {"text": "Interestingly, miR-21 expression positively correlated with urine albumin creatine ratio (ACR), TIMP1, collagen IV (ColIV), and fibronectin (FN); while negatively correlated with creatine clearance ratio (Ccr) and MMP-9 protein.", "entity1": "miR-21", "entity2": "creatine", "span1": [15, 21], "span2": [74, 82]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2507": {"label": 3, "data": {"text": "Anastrozole and letrozole are both non-steroidal aromatase inhibitors that compete with the substrate for binding to the enzyme active site.", "entity1": "aromatase", "entity2": "letrozole", "span1": [49, 58], "span2": [16, 25]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"4061": {"label": 3, "data": {"text": "Jaspamide also inhibited other channels including Cav1.2, Cav3.2, and HCN2; however, the Kv11.1 (hERG) channel was minimally affected.", "entity1": "Cav1.2", "entity2": "Jaspamide", "span1": [50, 56], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2397": {"label": 0, "data": {"text": "Herein, we determined that a fiveamino acid C-terminal deletion of LeuRS, which does not complement a null strain, can form a ternary complex with the bI4 intron and its maturase splicing partner.", "entity1": "LeuRS", "entity2": "C", "span1": [67, 72], "span2": [44, 45]}, "weak_labels": [0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"11300": {"label": 8, "data": {"text": "The protein exhibited modest H(2)O(2)-dependent peroxidase activities with guaiacol, potassium iodide, and 2,2(')-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS).", "entity1": "peroxidase", "entity2": "2,2(')-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid", "span1": [48, 58], "span2": [107, 162]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11312": {"label": 1, "data": {"text": "Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues.", "entity1": "glutamate receptors", "entity2": "kainate", "span1": [67, 86], "span2": [48, 55]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11832": {"label": 1, "data": {"text": "However, NCFP provides greater mGlu5 subtype selectivity than does CPPHA, making it more suitable for studies of effects on mGlu5 in CNS preparations.", "entity1": "mGlu5", "entity2": "NCFP", "span1": [124, 129], "span2": [9, 13]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3907": {"label": 9, "data": {"text": "Cells exposed to \u03b1-MeDA showed an increase in intracellular glutathione (GSH) levels, which, at the 48 h time-point, was not dependent in the activity increase of \u03b3-glutamylcysteine synthetase (\u03b3-GCS), revealing a possible transient effect.", "entity1": "\u03b3-GCS", "entity2": "\u03b1-MeDA", "span1": [194, 199], "span2": [17, 23]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"8011": {"label": 3, "data": {"text": "Treatment with IMG and hyperoside resulted in significantly prolonged aPTT and PT and inhibition of the activities of thrombin and FXa, and IMG or hyperoside inhibited production of thrombin and FXa in HUVECs.", "entity1": "thrombin", "entity2": "hyperoside", "span1": [118, 126], "span2": [23, 33]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"13197": {"label": 5, "data": {"text": "This trial investigated the possibility of pharmacokinetic interactions between the AT1 receptor antagonist olmesartan medoxomil and the thiazide diuretic hydrochlorothiazide in healthy subjects.", "entity1": "AT1 receptor", "entity2": "olmesartan medoxomil", "span1": [84, 96], "span2": [108, 128]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2937": {"label": 8, "data": {"text": "Adenylosuccinate synthetase (AdSS) catalyzes the Mg2+ dependent condensation of a molecule of IMP with aspartate to form adenylosuccinate, in a reaction driven by the hydrolysis of GTP to GDP.", "entity1": "AdSS", "entity2": "Mg2+", "span1": [29, 33], "span2": [49, 53]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"12983": {"label": 8, "data": {"text": "Diacylglycerol (DAG) acts as an allosteric activator of protein kinase C (PKC) and is converted to phosphatidic acid by DAG kinase (DGK).", "entity1": "DAG kinase", "entity2": "DAG", "span1": [120, 130], "span2": [16, 19]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, 8, -1]},
+	"2119": {"label": 3, "data": {"text": "METHODS AND RESULTS: In 8 Langendorff-perfused rabbit hearts, veratridine (0.1 microM), an inhibitor of sodium channel inactivation, led to a marked increase in QT-interval and simultaneously recorded monophasic ventricular action potentials (MAPs) (p < 0.05) thereby mimicking LQT3.", "entity1": "sodium channel", "entity2": "veratridine", "span1": [104, 118], "span2": [62, 73]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1352": {"label": 1, "data": {"text": "A series of mazindol (2) and homomazindol (3) analogues with a variety of electron-donating and electron-withdrawing groups in the pendant aryl group and the benzo ring C, as well as H, methoxy, and alkyl groups replacing the hydroxyl group were synthesized, and their binding affinities at the dopamine transporter (DAT) on rat or guinea pig striatal membranes were determined.", "entity1": "dopamine transporter", "entity2": "benzo", "span1": [295, 315], "span2": [158, 163]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"9122": {"label": 1, "data": {"text": "The binding of phenoxybenzamine to calmodulin was fairly selective in that other alpha-adrenergic agents such as prazosin, yohimbine and clonidine failed to bind to calmodulin when examined under the same experimental conditions.", "entity1": "calmodulin", "entity2": "phenoxybenzamine", "span1": [35, 45], "span2": [15, 31]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14947": {"label": 1, "data": {"text": "There has been much recent interest in lysophosphatidic acid (LPA) signaling through one of its receptors, LPA1, in fibrotic diseases, but the mechanisms by which LPA-LPA1 signaling promotes pathological fibrosis remain to be fully elucidated.", "entity1": "LPA1", "entity2": "LPA", "span1": [167, 171], "span2": [163, 166]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14961": {"label": 1, "data": {"text": "The peptide YR-11 (YLEIEFSLKHR), obtained by direct substitution of cysteine with a serine residue in the template sequence, significantly (p<0.05) inhibited RANK-RANKL binding, and RANKL induced TRAP activity and formation of multinucleated osteoclasts without any cytotoxicity.", "entity1": "RANKL", "entity2": "YR-11", "span1": [163, 168], "span2": [12, 17]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7621": {"label": 3, "data": {"text": "BACKGROUND: Lapatinib, the first dual inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) tyrosine kinases, was approved by the US Food and Drug Administration (FDA) in 2007.", "entity1": "epidermal growth factor receptor", "entity2": "Lapatinib", "span1": [51, 83], "span2": [12, 21]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6522": {"label": 3, "data": {"text": "Angiotensin II suppression in humans by the orally active renin inhibitor Aliskiren (SPP100): comparison with enalapril.", "entity1": "renin", "entity2": "Aliskiren", "span1": [58, 63], "span2": [74, 83]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13882": {"label": 3, "data": {"text": "Here, we report that the transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma) is essential for coupling ibuprofen to RhoA inhibition and subsequent neurite growth promotion in neurons.", "entity1": "RhoA", "entity2": "ibuprofen", "span1": [146, 150], "span2": [133, 142]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15307": {"label": 2, "data": {"text": "We found that atorvastatin withdrawal decreased levels of nitric oxide and mitochondrial superoxide dismutase activity, whereas increased NADPH oxidase activity and immunoreactivity for the protein nitration marker 3-nitrotyrosine in the cerebral cortex.", "entity1": "NADPH oxidase", "entity2": "3-nitrotyrosine", "span1": [138, 151], "span2": [215, 230]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"70": {"label": 4, "data": {"text": "The recent development of H1-receptor antagonists devoid of clinical sedative effects has enabled the administration of doses of H1-antihistamines which achieve a greater degree of H1-receptor blockade within the airways, thus permitting a better appraisal of the role of histamine in this condition.", "entity1": "H1-receptor", "entity2": "histamine", "span1": [26, 37], "span2": [272, 281]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1366": {"label": 8, "data": {"text": "Mazindol analogues as potential inhibitors of the cocaine binding site at the dopaminedopamine transporter.", "entity1": "dopamine transporter", "entity2": "dopamine", "span1": [86, 106], "span2": [78, 86]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"7348": {"label": 8, "data": {"text": "Na+-Dependent transmembrane transport of small neutral amino acids, such as glutamine and alanine, is mediated, among others, by the neutral amino acid transporters of the solute carrier 1 [SLC1, alanine serine cysteine transporter 1 (ASCT1), and ASCT2] and SLC38 families [sodium-coupled neutral amino acid transporter 1 (SNAT1), SNAT2, and SNAT4].", "entity1": "SNAT2", "entity2": "alanine", "span1": [331, 336], "span2": [90, 97]}, "weak_labels": [0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"12757": {"label": 2, "data": {"text": "The ratio of TGF-beta1 absorbed light value to GAPDH absorbed light value in the SHR group was 0.887+/-0.019, which was significantly higher than that in WKY group, imidapril group, and irbesartan group with the ratios of 0.780+/-0.018, 0.803+/-0.005, and 0.847+/-0.017, respectively (P<0.01).", "entity1": "TGF-beta1", "entity2": "irbesartan", "span1": [13, 22], "span2": [186, 196]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13943": {"label": 5, "data": {"text": "Recent studies indicate that tamoxifen initially acts as an antagonist, but later functions as an ER agonist, promoting tumor growth.", "entity1": "ER", "entity2": "tamoxifen", "span1": [98, 100], "span2": [29, 38]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6700": {"label": 5, "data": {"text": "Known VR1 antagonists (BCTC, thio-BCTC and capsazepine) were also able to block the response of TRPM8 to menthol (IC(50): 0.8+/-1.0, 3.5+/-1.1 and 18+/-1.1 microM, respectively).", "entity1": "VR1", "entity2": "thio-BCTC", "span1": [6, 9], "span2": [29, 38]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6718": {"label": 3, "data": {"text": "Compounds of several other structural families, including the quinoxaline AG1296, the bis(1H-2-indolyl)-1-methanone D-65476, the indolinones SU5416 and SU11248, the indolocarbazoles PKC412 and CEP-701, and the piperazonyl quinazoline CT53518, are potent inhibitors of Flt3 kinase.", "entity1": "Flt3", "entity2": "quinoxaline", "span1": [268, 272], "span2": [62, 73]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3013": {"label": 5, "data": {"text": "The ARB eprosartan is a nonbiphenyl nontetrazole angiotensin II type 1 receptor (AT1) antagonist, which acts to decrease total peripheral resistance.", "entity1": "AT1", "entity2": "eprosartan", "span1": [81, 84], "span2": [8, 18]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4915": {"label": 3, "data": {"text": "In the in vitro assay, kinsenoside (20 and 50\u03bcg/mL) markedly inhibited changes in various biochemical substances (nitric oxide (NO), lactic dehydrogenase (LDH), superoxide dismutase (SOD), and catalase (CAT)) in human umbilical vein endothelial cells (HUVECs) damaged by high glucose (35mM) and restored vascular endothelial structure by balancing the matrix metalloproteinases-the tissue inhibitors of matrix metalloproteinases (MMP-TIMP) system.", "entity1": "LDH", "entity2": "kinsenoside", "span1": [155, 158], "span2": [23, 34]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7947": {"label": 2, "data": {"text": "In contrast, activation of both ERK and CREB in the PFC was found following memory retrieval but not other processes in METH-treated mouse groups.", "entity1": "CREB", "entity2": "METH", "span1": [40, 44], "span2": [120, 124]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"8708": {"label": 2, "data": {"text": "To delineate the pathogenesis, we examined changes in the mRNA levels of 2 angiotensin II Type I receptor (AT1R) subtypes, AT1AR and AT1BR, in a mouse aortic endothelial cell line, END-D. Quantitative real-time PCR analysis revealed significant increases in the mRNA levels of 2 AT1R subtypes, AT1AR and AT1BR following sodium arsenite (SA) treatment.", "entity1": "AT1BR", "entity2": "sodium arsenite", "span1": [304, 309], "span2": [320, 335]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"995": {"label": 3, "data": {"text": "Given that FRD, present in all H. pylori strains, is immunogenic in H. pylori -infected patients and H. pylori growth in vitro can be inhibited by three anthelmintics (morantel, oxantel and thiabendazole), this enzyme could potentially be used both as a novel drug target as well as in the development of vaccines for H. pylori prevention and eradication.", "entity1": "FRD", "entity2": "oxantel", "span1": [11, 14], "span2": [178, 185]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11698": {"label": 3, "data": {"text": "The obtained results showed that pioglitazone improved the renal function, structural changes, renal malondialdehyde (MDA), tumor necrosis factor alpha (TNF-\u03b1), nuclear factor kappa B (NF-\u03baB) genes expression in cisplatin injected rats.", "entity1": "nuclear factor kappa B", "entity2": "cisplatin", "span1": [161, 183], "span2": [212, 221]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15073": {"label": 2, "data": {"text": "The increase in SAA expression is specific to ritodrine-induced liver damage, because SAA expression was not induced by other hepatotoxic drugs such as acetaminophen, valproic acid, or metformin.", "entity1": "SAA", "entity2": "ritodrine", "span1": [16, 19], "span2": [46, 55]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"10341": {"label": 2, "data": {"text": "The results show that transient arsenite pre-treatment induces Hsp72, HO-1 and, to a lesser extent, Hsp27; it reduces H2O2-induced astrocyte death; and it causes selective activation of Akt following H2O2.", "entity1": "Hsp72", "entity2": "arsenite", "span1": [63, 68], "span2": [32, 40]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"194": {"label": 3, "data": {"text": "Although inhibition of LH release can be achieved by estrogen and progestins, an optimal inhibitory effect on the prostate is obtained by the combined administration of the antiandrogen with an LHRH agonist that causes a specific blockage of testicular androgen biosynthesis as well as an inhibition of the LH responsiveness to LHRH.", "entity1": "LH", "entity2": "estrogen", "span1": [23, 25], "span2": [53, 61]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5009": {"label": 3, "data": {"text": "Sixteen of 34 CGPs inhibited MRP1-mediated E217\u03b2G uptake by >50% (IC50's 0.7-7.6 \u03bcM).", "entity1": "MRP1", "entity2": "CGPs", "span1": [29, 33], "span2": [14, 18]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10012": {"label": 5, "data": {"text": "In guinea-pig isolated colon, AS-8112 produced a rightward shift of the concentration-response curves of 2-methyl-5HT, a 5-HT3 receptor agonist (pA2 value of 7.04).", "entity1": "5-HT3 receptor", "entity2": "AS-8112", "span1": [121, 135], "span2": [30, 37]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"15297": {"label": 2, "data": {"text": "The most potent compound 5 (HJC0123) has demonstrated to inhibit STAT3 promoter activity, downregulate phosphorylation of STAT3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar IC50 values.", "entity1": "caspase-3", "entity2": "HJC0123", "span1": [164, 173], "span2": [28, 35]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1412": {"label": 1, "data": {"text": "Nevertheless, this action has generally been ignored in the mechanism of action of lisuride, in favor of an exclusive role for dopamine receptors in considering its antiparkinsonian effects, or an exclusive role of 5-HT(2A/2C) receptor activation in hallucinogenesis.", "entity1": "dopamine receptors", "entity2": "lisuride", "span1": [127, 145], "span2": [83, 91]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1171": {"label": 2, "data": {"text": "Mitiglinide (KAD-1229), a new anti-diabetic drug, is thought to stimulate insulin secretion by closing the ATP-sensitive K+ (K(ATP)) channels in pancreatic beta-cells.", "entity1": "insulin", "entity2": "KAD-1229", "span1": [74, 81], "span2": [13, 21]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12046": {"label": 9, "data": {"text": "Here, we show that rTRPV1, rTRPV2, rTRPV3, and mTRPV4, as well as hTRPM8, and rTRPM3, which are expressed in dorsal root ganglion neurons, are insensitive toward apomorphine treatment.", "entity1": "rTRPV1", "entity2": "apomorphine", "span1": [19, 25], "span2": [162, 173]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5156": {"label": 3, "data": {"text": "Furthermore, PD98059 (ERK1/2 inhibitor) significantly enhanced 2-hydroxy-3-methylanthraquinone-induced apoptosis in U937 cells, whereas caspase-3 inhibitor or SB203580 (p-p38MAPK inhibitor), decreased apoptosis in U937 cells.", "entity1": "p-p38MAPK", "entity2": "SB203580", "span1": [169, 178], "span2": [159, 167]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12566": {"label": 2, "data": {"text": "In summary, these results show that the excitatory effect of histamine on immunohistochemically identified vasopressin neurons in the supraoptic nucleus is due in part to the H1-receptor-mediated enhancement of the depolarizing afterpotential independent of any change in the afterhyperpolarizing potential or membrane potential.", "entity1": "H1-receptor", "entity2": "histamine", "span1": [175, 186], "span2": [61, 70]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8641": {"label": 3, "data": {"text": "Ovarian AR was not influenced by either treatment, and oviduct AR was reduced after ethanol-melatonin combination.", "entity1": "AR", "entity2": "ethanol", "span1": [63, 65], "span2": [84, 91]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"2779": {"label": 8, "data": {"text": "In the presence of the system L inhibitor BCH, Na(+)-dependent l-alanine uptake in WKY and SHR PTE cells was inhibited by alanine, serine, and cysteine, which is consistent with amino acid transport through ASCT2.", "entity1": "ASCT2", "entity2": "l-alanine", "span1": [207, 212], "span2": [63, 72]}, "weak_labels": [0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"11019": {"label": 3, "data": {"text": "We compared the effects of Captopril (an ACE inhibitor with -SH group), enalapril (an ACE-inhibitor without -SH group), N-acetylcysteine (only -SH group not ACE inhibitor) on endothelial dysfunction injured by methionine-induced hyperhomocysteinemia (HHcy) in rats.", "entity1": "ACE", "entity2": "Captopril", "span1": [41, 44], "span2": [27, 36]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"1286": {"label": 0, "data": {"text": "A hybrid cDNA was created by fusing a human cDNA for amino acids 1-101 of GAD67 to a human cDNA for amino acids 96-585 of GAD65; the recombinant (r) protein was expressed in yeast and was shown to have equivalent immunoreactivity to mammalian brain GAD with diabetes sera.", "entity1": "GAD67", "entity2": "amino acids", "span1": [74, 79], "span2": [53, 64]}, "weak_labels": [0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5194": {"label": 1, "data": {"text": "Though FUR alone obviously induced endoplasmic reticulum stress, this signaling pathway may not contribute to the synergetic anti-proliferative effect as the protein expression of CHOP and BIP was similar in FUR alone and combined treatment group.", "entity1": "BIP", "entity2": "FUR", "span1": [189, 192], "span2": [208, 211]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"11231": {"label": 1, "data": {"text": "The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide.", "entity1": "ATP-sensitive K+ channels", "entity2": "KAD-1229", "span1": [68, 93], "span2": [28, 36]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3637": {"label": 2, "data": {"text": "NaAsO(2) increased the mRNA levels of the light and medium subunits of neurofilament and decreased the mRNA levels of tau and tubulin in a dose-dependent manner; no significant effect was found in the mRNA levels of the heavy subunit of neurofilament, microtubule-associated protein 2, or actin.", "entity1": "light and medium subunits of neurofilament", "entity2": "NaAsO(2)", "span1": [42, 84], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10043": {"label": 2, "data": {"text": "Rosiglitazone modestly increased apolipoprotein C-III mRNA and had no effect on expression of the other 2 genes in the liver but increased the expression of glucose transporter 4 and phosphoenolpyruvate carboxykinase in adipose tissue.", "entity1": "apolipoprotein C-III", "entity2": "Rosiglitazone", "span1": [33, 53], "span2": [0, 13]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"13899": {"label": 3, "data": {"text": "CONCLUSION: ACE inhibitors, such as captopril, may be applied as important compounds for MMP-2 inhibition in inflammation caused by CAPD.", "entity1": "MMP-2", "entity2": "captopril", "span1": [89, 94], "span2": [36, 45]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6303": {"label": 5, "data": {"text": "These responses were effectively blocked by the 5-HT1B receptor antagonist, isamoltane, the 5-HT1B/5-HT2 receptor antagonist, methiothepin, and the eNOS selective antagonists (0.01-10 microM): L-Nomega -monomethyl-L-arginine (L-NMMA) and L-N omega-iminoethyl-L-ornithine (L-NIO).", "entity1": "5-HT1B", "entity2": "methiothepin", "span1": [92, 98], "span2": [126, 138]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4117": {"label": 2, "data": {"text": "G6pc2 deletion resulted in a leftward shift in the dose-response curve for glucose-stimulated insulin secretion (GSIS).", "entity1": "insulin", "entity2": "glucose", "span1": [94, 101], "span2": [75, 82]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1853": {"label": 3, "data": {"text": "Carbonic anhydrase inhibitors: aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity.", "entity1": "Carbonic anhydrase", "entity2": "adamantyl", "span1": [0, 18], "span2": [84, 93]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1715": {"label": 1, "data": {"text": "Molecular analysis of these mutants revealed single base pair exchanges in the ERG1 gene coding for squalene epoxidase, the target of terbinafine.", "entity1": "ERG1", "entity2": "terbinafine", "span1": [79, 83], "span2": [134, 145]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5351": {"label": 2, "data": {"text": "S1P activated phosphatidylinositol 3-kinase (PI3K)/Akt signaling, leading to the inhibition of glycogen synthase kinase-3\u03b2 and the nuclear translocation of \u03b2-catenin, followed by the increase of the transcriptional activity by \u03b2-catenin/T-cell factor complex formation in both SaOS-2 cells and MC3T3-E1 cells.", "entity1": "PI3K", "entity2": "S1P", "span1": [45, 49], "span2": [0, 3]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8538": {"label": 9, "data": {"text": "In addition, high ErbB3 and Muc1 expression was correlated with sensitivity to elisidepsin, whereas the presence of KRAS activating mutations was associated with resistance.", "entity1": "KRAS", "entity2": "elisidepsin", "span1": [116, 120], "span2": [79, 90]}, "weak_labels": [-1, -1, 0, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11880": {"label": 1, "data": {"text": "We examined the effects of anthocyanidins (cyanidin, delphinidin, malvidin, peonidin, petunidin, pelargonidin) on the aryl hydrocarbon receptor (AhR)-CYP1A1 signaling pathway in human hepatocytes, hepatic HepG2 and intestinal LS174T cancer cells.", "entity1": "CYP1A1", "entity2": "anthocyanidins", "span1": [150, 156], "span2": [27, 41]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3255": {"label": 1, "data": {"text": "The rates of hAR transport for the exogenous steroids methyltrienelone (MET), nandrolone (NAN), and oxandrolone (OXA) are lower than that of testosterone and similar to those of the endogenous steroids ANE and DHT.", "entity1": "hAR", "entity2": "steroids", "span1": [13, 16], "span2": [45, 53]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"8535": {"label": 2, "data": {"text": "Results indicate that CDM inhibits HSV-2 multiplication in epithelial cells and also increases cytokine production in macrophages, both important actions to the clearance of infecting virus in the mouse vagina.", "entity1": "cytokine", "entity2": "CDM", "span1": [95, 103], "span2": [22, 25]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"7681": {"label": 3, "data": {"text": "Thiazide and high ceiling diuretics were recently shown to inhibit all mammalian isoforms of carbonic anhydrase (CA, EC 4.2.1.1) with a very different profile as compared to classical inhibitors, such as acetazolamide, methazolamide, and ethoxzolamide.", "entity1": "EC 4.2.1.1", "entity2": "ethoxzolamide", "span1": [117, 127], "span2": [238, 251]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10298": {"label": 8, "data": {"text": "These findings suggest that RhBG and RhCG may play important and cell-specific roles in ammonium transport and signaling in these regions of the kidney.", "entity1": "RhBG", "entity2": "ammonium", "span1": [28, 32], "span2": [88, 96]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"3346": {"label": 1, "data": {"text": "The high resolution NMR solution structure of the cTnC-cTnI-dfbp-o ternary complex showed that dfbp-o bound at the hydrophobic interface formed by cTnC and cTnI making critical interactions with residues such as Arg147 of cTnI.", "entity1": "cTnC", "entity2": "dfbp-o", "span1": [50, 54], "span2": [60, 66]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13127": {"label": 1, "data": {"text": "Mifepristone alters expression of endometrial steroid receptors and their cofactors in new users of medroxyprogesterone acetate.", "entity1": "steroid receptors", "entity2": "Mifepristone", "span1": [46, 63], "span2": [0, 12]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 7, -1, -1, -1, -1, -1, -1]},
+	"13880": {"label": 3, "data": {"text": "In addition, another study suggests that ibuprofen reduces generation of amyloid-beta42 peptide via inactivation of RhoA signaling, although it may also regulate amyloid-beta42 formation by direct inhibition of the gamma-secretase complex.", "entity1": "RhoA", "entity2": "ibuprofen", "span1": [116, 120], "span2": [41, 50]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"10095": {"label": 8, "data": {"text": "The time course of PGE2 production was consistent with early release due to COX-1 activity followed by increased production 2-3 hours after surgery, consistent with COX-2 expression.", "entity1": "COX-2", "entity2": "PGE2", "span1": [165, 170], "span2": [19, 23]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"12526": {"label": 2, "data": {"text": "When menadione was omitted from the diet, however, 4HPR-dosed animals had elevated prothrombin times.", "entity1": "prothrombin", "entity2": "4HPR", "span1": [83, 94], "span2": [51, 55]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12843": {"label": 1, "data": {"text": "However, there were some significant differences among Captopril (30 mg/kg or 45 mg/kg), enalapril (20 mg/kg), and N-acetylcysteine particular in the activity of PON1 and ACE.", "entity1": "ACE", "entity2": "Captopril", "span1": [171, 174], "span2": [55, 64]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14246": {"label": 1, "data": {"text": "Androstanol and androstenol, estrone, 17\u03b2-estradiol, TCPOBOP, and CITCO showed compound-specific but similar affinities for both CARs.", "entity1": "CARs", "entity2": "androstenol", "span1": [129, 133], "span2": [16, 27]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12028": {"label": 1, "data": {"text": "Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase.", "entity1": "lactoperoxidase", "entity2": "iodide", "span1": [75, 90], "span2": [13, 19]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9983": {"label": 1, "data": {"text": "In a search for less flexible analogues of caproctamine (1), a diamine diamide endowed with an interesting AChE affinity profile, we discovered compound 2, in which the terminal 2-methoxybenzyl groups of 1 have been incorporated into a tricyclic system.", "entity1": "AChE", "entity2": "caproctamine", "span1": [107, 111], "span2": [43, 55]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8698": {"label": 8, "data": {"text": "These results suggest that ZIP8 plays a pivotal role in the transport and toxicity of Cd(2+) and Mn(2+) in RBL-2H3 cells.", "entity1": "ZIP8", "entity2": "Mn(2+)", "span1": [27, 31], "span2": [97, 103]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"11544": {"label": 3, "data": {"text": "Repression of HDC gene expression and HDC activity by dexamethasone may underlie its therapeutic effect in the treatment of allergy.", "entity1": "HDC", "entity2": "dexamethasone", "span1": [38, 41], "span2": [54, 67]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1095": {"label": 3, "data": {"text": "Moreover, the rank order for potency in inhibiting acetylcholinesterase (ambenonium>neostigmine=physostigmine =tacrine>pyridostigmine=edrophonium=galanthamine >desoxypeganine>parathion>gramine) indicated that the most effective inhibitors of acetylcholinesterase also displaced [3H]-oxotremorine-M to the greatest extent.", "entity1": "acetylcholinesterase", "entity2": "ambenonium", "span1": [242, 262], "span2": [73, 83]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3722": {"label": 3, "data": {"text": "Furthermore, N-BPs decreased the levels of phosphorylated extracellular signal-regulated kinase (ERK) and mTOR via suppression of Ras prenylation and enhanced Bim expression.", "entity1": "Ras", "entity2": "N", "span1": [130, 133], "span2": [13, 14]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14940": {"label": 3, "data": {"text": "Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide derivatives as novel Mcl-1 inhibitors.", "entity1": "Mcl-1", "entity2": "N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide", "span1": [146, 151], "span2": [63, 124]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11655": {"label": 3, "data": {"text": "The effects of CDCA and GW4064 on expression of Cdx2 and MUC2 were abolished by guggulsterone.", "entity1": "Cdx2", "entity2": "guggulsterone", "span1": [48, 52], "span2": [80, 93]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5433": {"label": 3, "data": {"text": "A series of benzenesulfonamides incorporating cyanoacrylamide moieties (tyrphostine analogs) were assayed as inhibitors of the \u03b2-carbonic anhydrase (CA, EC 4.2.1.1) from Saccharomyces cerevisiae, ScCA.", "entity1": "\u03b2-carbonic anhydrase", "entity2": "benzenesulfonamides", "span1": [127, 147], "span2": [12, 31]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5143": {"label": 1, "data": {"text": "An intermediate GTX2,3-aldehyde was first synthesized by activating the NH2 group of the 2nd and 8th amino acid residues with three different aldehydes and two artificial complete antigens GTX2,3-aldehyde-bovine serum albumin (BSA) and GTX2,3-aldehyde- keyhole limpet hemocyanin (KLH) were then prepared by cross-linking the intermediate with BSA or KLH.", "entity1": "KLH", "entity2": "GTX2,3-aldehyde", "span1": [280, 283], "span2": [236, 251]}, "weak_labels": [0, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12172": {"label": 1, "data": {"text": "A G-protein coupled receptor to niacin (nicotinic acid) was identified recently but the physiological/pharmacological role of the receptor remains poorly defined.", "entity1": "G-protein coupled receptor", "entity2": "nicotinic acid", "span1": [2, 28], "span2": [40, 54]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10151": {"label": 1, "data": {"text": "ICI 182,780 (fulvestrant) (Faslodex) and ICI 164,384 are competitive inhibitors of estrogen by binding to the estrogen receptor (ER).", "entity1": "estrogen receptor", "entity2": "estrogen", "span1": [110, 127], "span2": [83, 91]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8571": {"label": 4, "data": {"text": "Other dams received 1.8ng/kg/day of a mixture of aryl hydrocarbon receptor (AhR) agonists (non-ortho PCBs, PC-dibenzodioxins and PC-dibenzofurans) without or with 0.5M (0.5MAhR).", "entity1": "aryl hydrocarbon receptor", "entity2": "PC-dibenzodioxins", "span1": [49, 74], "span2": [107, 124]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2653": {"label": 9, "data": {"text": "Blockade of PDE1 (8-methoxymethyl-3-isobutyl-1-methylxanthine, 100 microM), PDE2 [erythro-9-(2-hydroxy-3-nonyl)adenine, 30 microM], PDE3 (milrinone, 10 microM; cGMP, 10 microM), PDE4 (Ro 20-1724 [4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one], 100 microM), PDE5 and PDE6 (zaprinast, 30 microM), and PDE7 [BRL-50481 (5-nitro-2,N,N-trimethylbenzenesulfonamide), 10 microM] did not alter renal ecto-phosphodiesterase activity.", "entity1": "phosphodiesterase", "entity2": "zaprinast", "span1": [397, 414], "span2": [273, 282]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"15677": {"label": 3, "data": {"text": "Moreover, curcumin could also down-regulate the expression and activity of matrix metalloproteinase-9 (MMP-9).", "entity1": "matrix metalloproteinase-9", "entity2": "curcumin", "span1": [75, 101], "span2": [10, 18]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3323": {"label": 1, "data": {"text": "MXF or VP-16 slightly affected cellular topo II activity in nuclear extracts derived from drug-treated cells while the combination enhanced inhibitory activity and the reduction in band depletion of topo II.", "entity1": "topo II", "entity2": "VP-16", "span1": [40, 47], "span2": [7, 12]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8799": {"label": 2, "data": {"text": "Here we show that fisetin rapidly increases the levels of both Nrf2 and ATF4 as well as Nrf2- and ATF4-dependent gene transcription via distinct mechanisms.", "entity1": "Nrf2", "entity2": "fisetin", "span1": [88, 92], "span2": [18, 25]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6387": {"label": 8, "data": {"text": "Ornithine decarboxylase (ODC) catalyses the first step in the synthesis of the polyamines putrescine, spermidine and spermine.", "entity1": "Ornithine decarboxylase", "entity2": "putrescine", "span1": [0, 23], "span2": [90, 100]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"2799": {"label": 2, "data": {"text": "Furthermore, substance P (SP) concentration in the acini and expression of SP gene (preprotachykinin-A, PPT-A) and neurokinin-1 receptor (NK-1R), the primary receptor for SP, are increased in secretagogue caerulein-treated acinar cells.", "entity1": "neurokinin-1 receptor", "entity2": "caerulein", "span1": [115, 136], "span2": [205, 214]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9529": {"label": 3, "data": {"text": "Dihydropyridines (DHPs) block L-type Ca2+ channels more potently at depolarized membrane potentials, consistent with high affinity binding to the inactivated state.", "entity1": "L-type Ca2+ channels", "entity2": "DHPs", "span1": [30, 50], "span2": [18, 22]}, "weak_labels": [-1, -1, -1, 1, -1, 1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9633": {"label": 1, "data": {"text": "Analogous to the antiandrogens, bicalutamide and hydroxyflutamide, binding of estramustine phosphate metabolites to the androgen receptor was observed.", "entity1": "androgen receptor", "entity2": "estramustine phosphate", "span1": [120, 137], "span2": [78, 100]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14754": {"label": 1, "data": {"text": "Jaceosidin induced G2/M phase cell cycle arrest and modulated the levels of cyclin B and p-Cdc2 in Hec1A cells.", "entity1": "p-Cdc2", "entity2": "Jaceosidin", "span1": [89, 95], "span2": [0, 10]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14855": {"label": 3, "data": {"text": "Moreover, Acrolein resulted in activation of astrocytes, up-regulation of BACE-1 in cortex and down-regulation of ADAM-10 in hippocampus and cortex.", "entity1": "ADAM-10", "entity2": "Acrolein", "span1": [114, 121], "span2": [10, 18]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6114": {"label": 3, "data": {"text": "Previous studies have resulted in the classification of amezinium as a selective inhibitor of neuronal monoamine oxidase (MAO), because it is a much more potent MAO inhibitor in intact tissues, in which it is accumulated in noradrenergic neurones by uptake1, than in tissue homogenates.", "entity1": "monoamine oxidase", "entity2": "amezinium", "span1": [103, 120], "span2": [56, 65]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1410": {"label": 1, "data": {"text": "These conclusions are surprising when one considers that the potent interaction of lisuride with 5-HT(1A) receptors has been demonstrated in several different laboratories and that activation of 5-HT(1A) and 5-HT(1B) receptors can modulate dopaminergically mediated responses.", "entity1": "5-HT(1A)", "entity2": "lisuride", "span1": [97, 105], "span2": [83, 91]}, "weak_labels": [-1, -1, -1, -1, 1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"451": {"label": 5, "data": {"text": "Pretreatment of the tissues with combined 5-HT1/5-HT2 antagonists, methysergide (1 microM) or methiothepin (0.1 microM), significantly attenuated the inhibitory effect of epinastine on the noncholinergic contraction.", "entity1": "5-HT1", "entity2": "methysergide", "span1": [42, 47], "span2": [67, 79]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5526": {"label": 1, "data": {"text": "To determine the position of the phenyl ring of the aralkyloxyalkyl side chain of salmeterol in the beta 2AR binding site, we designed and synthesized the agonist photoaffinity label [(125)I]iodoazidosalmeterol ([125I]IAS).", "entity1": "beta 2AR", "entity2": "aralkyloxyalkyl", "span1": [100, 108], "span2": [52, 67]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10200": {"label": 3, "data": {"text": "In rats, rifamycin SV and rifampicin were shown to interfere with hepatic organic anion uptake by inhibition of the organic anion transporting polypeptides Oatp1 and Oatp2.", "entity1": "Oatp1", "entity2": "rifampicin", "span1": [156, 161], "span2": [26, 36]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"12053": {"label": 1, "data": {"text": "Our results demonstrated that acute As(III) treatment (12.5\u2009mg/kg) altered CYP epoxygenases, CYP \u03c9-hydroxylases and EPHX2 mRNA levels that were isozyme and tissue specific.", "entity1": "CYP", "entity2": "As(III)", "span1": [75, 78], "span2": [36, 43]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13787": {"label": 3, "data": {"text": "The following TK blockers for treatment of various human tumors are in clinical development: Lapatinib (Lapatinib ditosylate, Tykerb, GW-572016), Canertinib (CI-1033), Zactima (ZD6474), Vatalanib (PTK787/ZK 222584), Sorafenib (Bay 43-9006, Nexavar), and Leflunomide (SU101, Arava).", "entity1": "TK", "entity2": "Sorafenib", "span1": [14, 16], "span2": [216, 225]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4312": {"label": 3, "data": {"text": "The Trx mimetics peptides (TXM) protected insulinoma INS 832/13 cells from oxidative stress induced by selectively inhibiting TrxR with auranofin (AuF).", "entity1": "TrxR", "entity2": "auranofin", "span1": [126, 130], "span2": [136, 145]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11320": {"label": 8, "data": {"text": "After 0 to 80 minutes (37 degrees C), 50-microL samples were withdrawn and added to 100 microL 1.5 M arginine, pH 8.7, and oxidized with 50 microL of 20 mM CT. For determination of plasmin activity, 10 microL thereof was incubated with 150 microL 1.5 M arginine, pH 8.7, and 100 microL 20 mM CT preoxidized (15 minutes 37 degrees C) pooled normal citrate buffered EDTA-plasma for 30 minutes (37 degrees C).", "entity1": "plasmin", "entity2": "arginine", "span1": [181, 188], "span2": [253, 261]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8730": {"label": 1, "data": {"text": "Kinetic analyses revealed that the affinity and clearance of UGT2B10 for amitriptyline, imipramine, and diphenhydramine are significantly higher than the corresponding values of UGT1A4 and UGT1A3, although the Vmax values of UGT1A4 toward these drugs are considerably higher.", "entity1": "UGT1A4", "entity2": "imipramine", "span1": [178, 184], "span2": [88, 98]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10933": {"label": 3, "data": {"text": "Clinical experience in heart failure is growing, and recent data suggest an improved survival with losartan versus captopril, a drug from the angiotensin-converting-enzyme inhibitor class with proven benefit in this population.", "entity1": "angiotensin-converting-enzyme", "entity2": "losartan", "span1": [142, 171], "span2": [99, 107]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1]},
+	"9117": {"label": 1, "data": {"text": "The site at which phenoxybenzamine bound to calmodulin appears to be similar to that at which certain antipsychotic agents bind, since several of them, including penfluridol, pimozide and spiroperidol, prevented the binding of phenoxybenzamine to calmodulin.", "entity1": "calmodulin", "entity2": "pimozide", "span1": [247, 257], "span2": [175, 183]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5055": {"label": 1, "data": {"text": "Taken together, our results suggested that Rg1 protected against A\u03b225-35-induced apoptosis at least in part by two complementary GR-dependent ERK phosphorylation pathways: (1) down-regulating HIF-1\u03b1 initiated protein nitrotyrosination, and (2) inhibiting mitochondrial apoptotic cascades.", "entity1": "GR", "entity2": "Rg1", "span1": [129, 131], "span2": [43, 46]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, 3, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8250": {"label": 0, "data": {"text": "N-terminal sequencing indicated that pro-BMP-2 was cleaved by FSAP at the canonical PC cleavage site, giving rise to mature BMP-2 (Arg(282)\u2193Gln(283)), as well as in the N-terminal heparin binding region of mature BMP-2, generating a truncated mature BMP-2 peptide (Arg(289)\u2193Lys(290)).", "entity1": "BMP-2", "entity2": "Arg", "span1": [124, 129], "span2": [131, 134]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9193": {"label": 2, "data": {"text": "This agent acts synergistically with many penicillins, such as ampicillin, carbenicillin, and the like, and with cephalosporins, cefazolin, cefamandole, or cefoxitin to inhibit gram-negative bacilli, probably on the basis of binding to different proteins needed for the production of the peptidoglycan of the bacterial cell wall.", "entity1": "peptidoglycan", "entity2": "cefoxitin", "span1": [288, 301], "span2": [156, 165]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"13556": {"label": 9, "data": {"text": "Arginase or nitric oxide synthase isoenzymes were not found to influence L-citrulline production.", "entity1": "nitric oxide synthase", "entity2": "L-citrulline", "span1": [12, 33], "span2": [73, 85]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, 9]},
+	"4430": {"label": 8, "data": {"text": "Type 2 11\u03b2-hydroxysteroid dehydrogenase encoded by the HSD11B2 gene converts cortisol to inactive cortisone, and alteration in this enzymatic activity might affect glucose homeostasis by affecting circulating levels or tissue availability of glucocorticoids.", "entity1": "HSD11B2", "entity2": "cortisol", "span1": [55, 62], "span2": [77, 85]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1]},
+	"13534": {"label": 8, "data": {"text": "However, upon addition of NO to CDO in the presence of substrate l-cysteine, a low-spin {FeNO}7 (S = 1/2) signal that accounts for approximately 85% of the iron within the enzyme develops.", "entity1": "CDO", "entity2": "l-cysteine", "span1": [32, 35], "span2": [65, 75]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"15213": {"label": 3, "data": {"text": "In HaCaT cells, buthanol and ethylacetate fractions of 80% methanol C. fragile extract (CFB or CFE) and a single compound, clerosterol (CLS) isolated from CFE attenuated UVB (60mJ/cm(2))-induced cytotoxicity and reduced expression of pro-inflammatory proteins including cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and tumor necrosis factor-\u03b1 (TNF- \u03b1).", "entity1": "inducible nitric oxide synthase", "entity2": "methanol", "span1": [296, 327], "span2": [59, 67]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10331": {"label": 4, "data": {"text": "Here, we characterize the activation of human pDC with the TLR7 agonists imiquimod and resiquimod.", "entity1": "TLR7", "entity2": "imiquimod", "span1": [59, 63], "span2": [73, 82]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11605": {"label": 8, "data": {"text": "Hydrogen sulphide (H(2)S) is synthesized from L-cysteine via the action of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS).", "entity1": "cystathionine-beta-synthase", "entity2": "L-cysteine", "span1": [111, 138], "span2": [46, 56]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10844": {"label": 3, "data": {"text": "Imatinib (STI571, Gleevec, Glivec; Novartis Pharmaceuticals, East Hanover, NJ), a selective inhibitor of KIT, ABL, BCR-ABL, PDGFRA, and PDGFRB, represents a new paradigm of targeted cancer therapy and has revolutionized the treatment of patients with chronic myelogenous leukemia and GISTs.", "entity1": "KIT", "entity2": "Gleevec", "span1": [105, 108], "span2": [18, 25]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2736": {"label": 3, "data": {"text": "PURPOSE: Dasatinib (BMS-354825), a potent oral multi-targeted kinase inhibitor against SRC and BCR-ABL, has recently been approved for the treatment of chronic myelogenous leukaemia (CML) in imatinib-acquired resistance and intolerance.", "entity1": "SRC", "entity2": "Dasatinib", "span1": [87, 90], "span2": [9, 18]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6400": {"label": 2, "data": {"text": "RESULTS: Quetiapine was an effective antipsychotic and improved the extrapyramidal symptoms and prolactin level elevation noted at baseline.", "entity1": "prolactin", "entity2": "Quetiapine", "span1": [96, 105], "span2": [9, 19]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"1641": {"label": 1, "data": {"text": "2-Amino-3-[3-hydroxy-5-(2-thiazolyl)-4-isoxazolyl]propionic acid (1) is a potent AMPA receptor agonist with moderate affinity for native kainic acid (KA) receptors, whereas (S)-E-4-(2,2-dimethylpropylidene)glutamic acid (3) show high affinity for the GluR5 subtype of KA receptors and much lower affinity for the GluR2 subtype of AMPA receptors.", "entity1": "KA receptors", "entity2": "(S)-E-4-(2,2-dimethylpropylidene)glutamic acid", "span1": [268, 280], "span2": [173, 219]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1033": {"label": 3, "data": {"text": "Topotecan is a topoisomerase I inhibitor which is currently evaluated as an adjuvant agent for malignant glioma.", "entity1": "topoisomerase I", "entity2": "Topotecan", "span1": [15, 30], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2813": {"label": 3, "data": {"text": "Dexamethasone (DXM) decreased the expression of CXCL-8, VEGF, and iNOS induced by reIL-4, while 1400W dihydrochloride (1400W), a selective inhibitor of iNOS, decreased the expression of E-selectin, VEGF, and iNOS.", "entity1": "iNOS", "entity2": "1400W", "span1": [208, 212], "span2": [119, 124]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10967": {"label": 1, "data": {"text": "mRNA levels for RAR-alpha, RAR-beta and RAR-gamma, the nuclear receptors for retinoic acid, decreased during activation of freshly isolated HSC even with retinoid supplementation.", "entity1": "RAR-alpha", "entity2": "retinoic acid", "span1": [16, 25], "span2": [77, 90]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3075": {"label": 3, "data": {"text": "PURPOSE: To compare phenelzine (PLZ), an antidepressant drug with anxiolytic properties which inhibits monoamine oxidase (MAO) but also elevates rat brain levels of the amino acids ?-aminobutyric acid (GABA) and alanine (ALA), with vigabatrin (VIG), an anticonvulsant which elevates brain GABA by inhibition of GABA transaminase (GABA-T), with regard to their actions on brain levels of GABA and ALA and on activities of MAO, GABA-T and ALA transaminase (ALA-T).", "entity1": "GABA-T", "entity2": "VIG", "span1": [330, 336], "span2": [244, 247]}, "weak_labels": [0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"853": {"label": 3, "data": {"text": "These findings suggest that troglitazone inhibits antigen-induced LT production in the IgE-sensitized RBL-2H3 cells and A23187-stimulated rat peritoneal neutrophils by direct inhibition of 5-LOX activity.", "entity1": "5-LOX", "entity2": "troglitazone", "span1": [189, 194], "span2": [28, 40]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"13972": {"label": 3, "data": {"text": "BACKGROUND: Recent epidemiologic and laboratory studies have suggested that non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the risk of breast cancer through inhibition of cyclooxygenase-2 (COX-2).", "entity1": "cyclooxygenase-2", "entity2": "steroidal", "span1": [182, 198], "span2": [80, 89]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8892": {"label": 2, "data": {"text": "Anabolic effects of clenbuterol on skeletal muscle are mediated by beta 2-adrenoceptor activation.", "entity1": "beta 2-adrenoceptor", "entity2": "clenbuterol", "span1": [67, 86], "span2": [20, 31]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2252": {"label": 1, "data": {"text": "In general, rifampicin can act on a pattern: rifampicin activates the nuclear pregnane X receptor that in turn affects cytochromes P450, glucuronosyltransferases and p-glycoprotein activities.", "entity1": "cytochromes P450", "entity2": "rifampicin", "span1": [119, 135], "span2": [12, 22]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1716": {"label": 1, "data": {"text": "The results strongly indicate that these regions are responsible for the interaction of yeast squalene epoxidase with terbinafine.", "entity1": "yeast squalene epoxidase", "entity2": "terbinafine", "span1": [88, 112], "span2": [118, 129]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14643": {"label": 8, "data": {"text": "Gemcitabine (dFdC, 2',2'-difluorodeoxycytidine) is metabolized by cytidine deaminase (CDA) and deoxycytidine kinase (DCK), but the contribution of genetic variation in these enzymes to the variability in systemic exposure and response observed in cancer patients is unclear.", "entity1": "CDA", "entity2": "2',2'-difluorodeoxycytidine", "span1": [86, 89], "span2": [19, 46]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11948": {"label": 9, "data": {"text": "The activities of UGTs 1A3, 1A8, 1A9, 2B4 and 2B7 were low, whereas UGT1A1 and UGT2B17 exhibited no HFC glucuronidation activity.", "entity1": "UGT1A1", "entity2": "HFC", "span1": [68, 74], "span2": [100, 103]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7825": {"label": 2, "data": {"text": "Cellular release of AChE by SH-SY5Y is significantly enhanced by the muscarinic acetylcholine receptor (mAChR) agonists carbachol or muscarine, with the effect of carbachol blocked by the mAChR antagonist atropine.", "entity1": "AChE", "entity2": "carbachol", "span1": [20, 24], "span2": [163, 172]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4397": {"label": 0, "data": {"text": "The M6P (mannose 6-phosphate)/IGF2R (insulin-like growth factor II receptor) interacts with a variety of factors that impinge on tumour invasion and metastasis.", "entity1": "insulin-like growth factor II receptor", "entity2": "mannose 6-phosphate", "span1": [37, 75], "span2": [9, 28]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5022": {"label": 8, "data": {"text": "Using a transient heterologous cell expression system, we find that the transport activities of the short OATP2B1 variant towards substrates estrone sulfate and rosuvastatin are similar to the well-characterized full length variant.", "entity1": "short OATP2B1", "entity2": "estrone sulfate", "span1": [100, 113], "span2": [141, 156]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, 8, -1, -1, -1, -1]},
+	"15074": {"label": 2, "data": {"text": "Our in vitro studies showed that cyclic adenosine 3',5'-monophosphate (cAMP) accumulation was not a primary cause of the ritodrine-induced SAA increase.", "entity1": "SAA", "entity2": "ritodrine", "span1": [139, 142], "span2": [121, 130]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"13303": {"label": 3, "data": {"text": "The ability of sorafenib to inhibit oncogenic PDGFRbeta and FLT3 mutants and overcome resistance to other small molecule inhibitors.", "entity1": "FLT3", "entity2": "sorafenib", "span1": [60, 64], "span2": [15, 24]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15806": {"label": 2, "data": {"text": "When dual angiogenic growth factors (GFs), such as platelet-derived GF (PDGF) and vascular endothelial GF (VEGF), are encapsulated separately in the core and shell domains, respectively, the VEGF release rate is much greater than that of PDGF, and the difference of the cumulative release percentage between the two GFs is about 30% on day 7 with LMW core PLGA and more than 45% with HMW core PLGA.", "entity1": "PDGF", "entity2": "PLGA", "span1": [238, 242], "span2": [393, 397]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13204": {"label": 7, "data": {"text": "Herein, comparative genomics and experimental analyses revealed that the mammalian Sec synthase (SecS) is the previously identified pyridoxal phosphate-containing protein known as the soluble liver antigen.", "entity1": "soluble liver antigen", "entity2": "pyridoxal phosphate", "span1": [184, 205], "span2": [132, 151]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10706": {"label": 1, "data": {"text": "Dextromethorphan and dimemorfan are high-affinity ligands at sigma1 receptors.", "entity1": "sigma1 receptors", "entity2": "dimemorfan", "span1": [61, 77], "span2": [21, 31]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15497": {"label": 0, "data": {"text": "Interestingly, following pBQN desensitization, wild-type TRPA1 had dramatically reduced response to the nonelectrophile agonist carvacrol, whereas the triple cysteine mutant TRPA1 retained its full response.", "entity1": "TRPA1", "entity2": "cysteine", "span1": [174, 179], "span2": [158, 166]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13627": {"label": 3, "data": {"text": "Rasagiline [N-propargyl-l(R)-aminoindan] is a second-generation propargylamine pharmacophore that selectively and irreversibly inhibits brain MAO-B and is specifically designed for the treatment of Parkinson's disease (PD).", "entity1": "MAO-B", "entity2": "Rasagiline", "span1": [142, 147], "span2": [0, 10]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9553": {"label": 1, "data": {"text": "In addition, the betaAR-mediated inhibition of IFN-gamma, GM-CSF, and IL-3 mRNA accumulation and GM-CSF protein secretion were related to the accumulation of intracellular cyclic adenosine monophosphate (cAMP) levels.", "entity1": "betaAR", "entity2": "cyclic adenosine monophosphate", "span1": [17, 23], "span2": [172, 202]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6555": {"label": 3, "data": {"text": "In contrast, the mutants T844A, F972A and Q975A showed increased K(i) for cilostazol but no difference for milrinone from the recombinant PDE3A.", "entity1": "F972A", "entity2": "cilostazol", "span1": [32, 37], "span2": [74, 84]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11973": {"label": 2, "data": {"text": "Meanwhile, autophagy was detected as early as 12\u00a0h after an exposure to low-dose dioscin, as indicated by an up-regulated expression of LC3-II and beclin-1 proteins.", "entity1": "beclin-1", "entity2": "dioscin", "span1": [147, 155], "span2": [81, 88]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2080": {"label": 3, "data": {"text": "These data demonstrated that 1) gemcitabine and pemetrexed synergistically interact against NSCLC cells through the suppression of Akt phosphorylation and induction of apoptosis; 2) the gene expression profile of critical genes may predict for drug chemosensitivity; and 3) pemetrexed enhances dCK and hENT1 expression, thus suggesting the role of gene-expression modulation for rational development of chemotherapy combinations.", "entity1": "Akt", "entity2": "gemcitabine", "span1": [131, 134], "span2": [32, 43]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1262": {"label": 4, "data": {"text": "The hyperglycemic effect of m-CPBG central administration was blocked by pretreatment with ondansetron, a specific 5-HT3 receptor antagonist, indicating that the effects here obtained with m-CPBG were a result of its interaction with 5-HT3 receptors.", "entity1": "5-HT3", "entity2": "m-CPBG", "span1": [115, 120], "span2": [28, 34]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12591": {"label": 1, "data": {"text": "The complex patterns of sensitivity to cyclothiazide seen in hippocampal neurons could be reconstituted by assembly of recombinant AMPA receptor subunits generated from cDNAs encoding the flip (i) and flop (o) splice variants of the GluR-A and GluR-B subunits.", "entity1": "GluR-B", "entity2": "cyclothiazide", "span1": [244, 250], "span2": [39, 52]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5662": {"label": 3, "data": {"text": "Long-term treatment with 1 \u03bcM matrine or oxymatrine increased expression of the hERG protein and rescued the hERG surface expression disrupted by As(2)O(3).", "entity1": "hERG", "entity2": "As(2)O(3)", "span1": [109, 113], "span2": [146, 155]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"181": {"label": 1, "data": {"text": "In vitro studies, however, revealed that EO inhibits fibrin clot formation because of the Ca2+-chelating ability of its constituent ethanolamine, although oleate or benzyl alcohol exhibited procoagulant activity in FPA formation in vitro.", "entity1": "FPA", "entity2": "benzyl alcohol", "span1": [215, 218], "span2": [165, 179]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6409": {"label": 3, "data": {"text": "Isoproterenol (50 to 100 nmol/L) was used to mimic an increase in beta-adrenergic tone, d-sotalol (100 micromol/L) to block I(Kr) (LQT2 model), and ATX-II (20 nmol/L) to augment late I(Na) (LQT3 model).", "entity1": "ATX-II", "entity2": "d-sotalol", "span1": [148, 154], "span2": [88, 97]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"896": {"label": 1, "data": {"text": "Contrasting effects of N5-substituted tetrahydrobiopterin derivatives on phenylalanine hydroxylase, dihydropteridine reductase and nitric oxide synthase.", "entity1": "phenylalanine hydroxylase", "entity2": "N5-substituted tetrahydrobiopterin", "span1": [73, 98], "span2": [23, 57]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12132": {"label": 3, "data": {"text": "Initial in vitro studies utilizing HEP-G2 liver cells revealed that addition of eicosapentaenoic acid (EPA) blocked Delta-5-desaturase activity, the terminal enzymatic step in AA synthesis.", "entity1": "Delta-5-desaturase", "entity2": "EPA", "span1": [116, 134], "span2": [103, 106]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9024": {"label": 2, "data": {"text": "In addition to effects on cell proliferation, DHT increased the percentage of alkaline phosphatase (ALP) positive cells in all three bone cell systems tested, and this effect was inhibited by antiandrogens.", "entity1": "ALP", "entity2": "DHT", "span1": [100, 103], "span2": [46, 49]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7714": {"label": 5, "data": {"text": "Palonosetron is a second-generation serotonin 5-HT3 receptor antagonist, with a distinct pharmacological profile that differs from first-generation 5-HT3 receptor antagonists.", "entity1": "5-HT3 receptor", "entity2": "Palonosetron", "span1": [148, 162], "span2": [0, 12]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3533": {"label": 2, "data": {"text": "2-Deoxyglucose increased phosphorylation of tuberous sclerosis complex 2 (TSC2) on AMPK consensus sites but did not change the amount of TSC1 bound to TSC2.", "entity1": "TSC2", "entity2": "2-Deoxyglucose", "span1": [151, 155], "span2": [0, 14]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"14848": {"label": 1, "data": {"text": "Interestingly, Acrolein increased proteins' levels of amyloid precursor protein (APP), \u03b2-secretase (BACE-1) and the amyloid \u03b2-peptide transporter receptor for advanced glycation end products, and decreased A-disintegrin and metalloprotease (ADAM) 10 levels.", "entity1": "APP", "entity2": "Acrolein", "span1": [81, 84], "span2": [15, 23]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, 8, -1, 8, -1, -1]},
+	"12298": {"label": 1, "data": {"text": "Quercetin supplementation altered expression profiles of several lipid metabolism-related genes, including Fnta, Pon1, Pparg, Aldh1b1, Apoa4, Abcg5, Gpam, Acaca, Cd36, Fdft1, and Fasn, relative to those in HFD control mice.", "entity1": "Gpam", "entity2": "Quercetin", "span1": [149, 153], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2520": {"label": 8, "data": {"text": "On the basis of our findings with structurally similar arylhydroxylamine metabolites of therapeutic drugs, we hypothesized that the reductive detoxification of arylhydroxylamine carcinogens was catalyzed by NADH cytochrome b5 reductase (b5R) and cytochrome b5 (cyt b5).", "entity1": "NADH cytochrome b5 reductase", "entity2": "arylhydroxylamine", "span1": [207, 235], "span2": [160, 177]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"6386": {"label": 8, "data": {"text": "Ornithine decarboxylase (ODC) catalyses the first step in the synthesis of the polyamines putrescine, spermidine and spermine.", "entity1": "ODC", "entity2": "putrescine", "span1": [25, 28], "span2": [90, 100]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"2099": {"label": 1, "data": {"text": "In higher cortical structures such as the hippocampus, norepinephrine, via beta adrenergic receptor (AR) activation, has been shown to reinforce the cognitive processes of attention and memory.", "entity1": "AR", "entity2": "norepinephrine", "span1": [101, 103], "span2": [55, 69]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4484": {"label": 3, "data": {"text": "Endothelium-dependent relaxations, nitric oxide (NO) and endothelium derived hyperpolarizing factor (EDHF)-type, were studied in rabbit iliac artery and aortic rings using the G protein-coupled receptor agonist acetylcholine (ACh) and by cyclopiazonic acid (CPA), which promotes store-operated Ca(2+) entry by inhibiting the endothelial SERCA pump.", "entity1": "SERCA", "entity2": "cyclopiazonic acid", "span1": [337, 342], "span2": [238, 256]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2056": {"label": 1, "data": {"text": "This alternate conformation now causes a steric hindrance to the O4 hydroxyl group of the Gal moiety of UDP-Gal, probably causing the dissociation of UDP-Gal and the reduced k(cat) of the Gal-T reaction.", "entity1": "Gal-T", "entity2": "Gal", "span1": [188, 193], "span2": [90, 93]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14897": {"label": 8, "data": {"text": "Analysis of natural genetic variation among inbred strains of mice indicates that FMO3 and TMAO are significantly correlated, and TMAO levels explain 11% of the variation in atherosclerosis.", "entity1": "FMO3", "entity2": "TMAO", "span1": [82, 86], "span2": [91, 95]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11712": {"label": 1, "data": {"text": "We examined the ability of the EPAC-selective cAMP analog 8-pCPT-2'-O-Me-cAMP-AM to potentiate the action of these drugs and the mechanism that might account for it.", "entity1": "EPAC", "entity2": "cAMP", "span1": [31, 35], "span2": [46, 50]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6765": {"label": 2, "data": {"text": "Hydralazine induced rapid and transient expression of HIF-1alpha and downstream targets of HIF (endothelin-1, adrenomedullin, haem oxygenase 1, and vascular endothelial growth factor [VEGF]) in endothelial and smooth muscle cells and induced endothelial cell-specific proliferation.", "entity1": "HIF-1alpha", "entity2": "Hydralazine", "span1": [54, 64], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9527": {"label": 3, "data": {"text": "Nisoldipine (a DHP antagonist) blocks the smooth muscle channel more potently than the cardiac one, a phenomenon observed not only in native channels but also in expressed channels.", "entity1": "smooth muscle channel", "entity2": "Nisoldipine", "span1": [42, 63], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"219": {"label": 1, "data": {"text": "Norethisterone metabolites modulate the uteroglobin and progesterone receptor gene expression in prepubertal rabbits.", "entity1": "uteroglobin", "entity2": "Norethisterone", "span1": [40, 51], "span2": [0, 14]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2445": {"label": 9, "data": {"text": "Colonic cyclooxygenase-2 and interkeukin-1beta mRNA and spinal c-FOS mRNA expression were significantly down-regulated by ATB-429, but not by mesalamine.", "entity1": "interkeukin-1beta", "entity2": "mesalamine", "span1": [29, 46], "span2": [142, 152]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"905": {"label": 7, "data": {"text": "Tetrahydrobiopterin [(6R)-5,6,7,8-tetrahydro-L-biopterin, H(4)biopterin] is one of several cofactors of nitric oxide synthases (EC 1.14.13.39).", "entity1": "nitric oxide synthases", "entity2": "H(4)biopterin", "span1": [104, 126], "span2": [58, 71]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 7, -1, -1, -1, -1, -1, -1]},
+	"12192": {"label": 1, "data": {"text": "Simvastatin regulates non-neuronal cholinergic activity in T lymphocytes via CD11a-mediated pathways.", "entity1": "CD11a", "entity2": "Simvastatin", "span1": [77, 82], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10870": {"label": 1, "data": {"text": "Late-onset diarrhea appears to be associated with intestinal exposure to SN-38 (7-ethyl-10-hydroxycamptothecin), the major active metabolite of CPT-11, which may bind to Topo I and induce apoptosis of intestinal epithelia, leading to the disturbance in the absorptive and secretory functions of mucosa.", "entity1": "Topo I", "entity2": "SN-38", "span1": [170, 176], "span2": [73, 78]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2973": {"label": 1, "data": {"text": "Change in affinity for cGMP, vardenafil, sildenafil, or IBMX in Y612F, H613A, L765A, or F786A was less, but affinity of H613A or F786A for tadalafil was weakened 37- and 17-fold, respectively.", "entity1": "F786A", "entity2": "sildenafil", "span1": [88, 93], "span2": [41, 51]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13290": {"label": 1, "data": {"text": "Sorafenib (BAY43-9006, Nexavar) is a small molecule B-RAF inhibitor that is used for the treatment of renal cell carcinoma, and has been shown to have activity against receptor tyrosine kinases from the platelet-derived growth factor receptor (PDGFR) and vascular endothelial growth factor receptor (VEGFR) families.", "entity1": "PDGFR", "entity2": "BAY43-9006", "span1": [244, 249], "span2": [11, 21]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10931": {"label": 1, "data": {"text": "Losartan is well-absorbed orally as an active drug and is rapidly converted via oxidation in the human liver to a more potent metabolite (designated E3174) with an affinity 20- to 30-times greater for the AT(1) receptor (non-competitive inhibition).", "entity1": "AT(1) receptor", "entity2": "Losartan", "span1": [205, 219], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1]},
+	"4823": {"label": 3, "data": {"text": "We previously employed a chemical genomic strategy to identify a novel small molecule, MAC13243, as a likely inhibitor of the bacterial lipoprotein targeting chaperone, LolA.", "entity1": "chaperone", "entity2": "MAC13243", "span1": [158, 167], "span2": [87, 95]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8349": {"label": 4, "data": {"text": "High throughput screening led to the identification of a novel series of quinolone \u03b17 nicotinic acetylcholine receptor (nAChR) agonists.", "entity1": "\u03b17 nicotinic acetylcholine receptor", "entity2": "quinolone", "span1": [83, 118], "span2": [73, 82]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2432": {"label": 1, "data": {"text": "SSTR2 and SSTR5 are usually expressed in GH-secreting pituitary tumors, and both octreotide and lanreotide bind preferentially to SSTR2 and, to a lesser extent, to SSTR5.", "entity1": "SSTR2", "entity2": "lanreotide", "span1": [130, 135], "span2": [96, 106]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6094": {"label": 3, "data": {"text": "Pretreatment with the dopamine D1 receptor antagonist, SCH23390, and the NMDA receptor antagonist, MK-801, blocked amantadine induction of Fos in the striatum.", "entity1": "Fos", "entity2": "MK-801", "span1": [139, 142], "span2": [99, 105]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14353": {"label": 3, "data": {"text": "mRNA levels of receptor activator of nuclear factor kappa-B (RANK), its ligand RANKL, tumor necrosis factor alpha (TNF-\u03b1) and RANKL/osteoprotegerin (OPG) ratio were diminished in the periodontium of CCL3(-/-) mice and in the group treated with Met-RANTES.", "entity1": "RANKL", "entity2": "Met", "span1": [126, 131], "span2": [244, 247]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3532": {"label": 2, "data": {"text": "Phosphorylation of ER-stress marker eIF2\u03b1 was also increased but only at 30 min of 2-deoxyglucose exposure.", "entity1": "eIF2\u03b1", "entity2": "2-deoxyglucose", "span1": [36, 41], "span2": [83, 97]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10170": {"label": 2, "data": {"text": "A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression.", "entity1": "histone deacetylase", "entity2": "theophylline", "span1": [62, 81], "span2": [35, 47]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15130": {"label": 3, "data": {"text": "Investigating the enteroenteric recirculation of apixaban, a factor Xa inhibitor: administration of activated charcoal to bile duct-cannulated rats and dogs receiving an intravenous dose and use of drug transporter knockout rats.", "entity1": "factor Xa", "entity2": "apixaban", "span1": [61, 70], "span2": [49, 57]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"3636": {"label": 9, "data": {"text": "We observed that the area ratio of neurite to cell body in SCAT3-expressing cells was significantly reduced by 5 and 10 \u03bcM NaAsO(2), but not by 1 \u03bcM, although the emission ratio of ECFP to Venus, an endpoint of caspase-3 activity, was not changed.", "entity1": "caspase-3", "entity2": "NaAsO(2)", "span1": [211, 220], "span2": [123, 131]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"3031": {"label": 8, "data": {"text": "Both risperidone and 9-hydroxyrisperidone are substrates of P-glycoprotein (P-gp), a transport protein involved in drug absorption, distribution, and elimination.", "entity1": "P-glycoprotein", "entity2": "risperidone", "span1": [60, 74], "span2": [5, 16]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, 8, -1, -1, -1, -1]},
+	"10000": {"label": 8, "data": {"text": "Contribution of the Na+-K+-2Cl- cotransporter NKCC1 to Cl- secretion in rat OMCD.", "entity1": "Na+-K+-2Cl- cotransporter", "entity2": "Cl-", "span1": [20, 45], "span2": [55, 58]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"8633": {"label": 2, "data": {"text": "Thus, arsenic activates Nrf2 through a non-canonical mechanism (p62-dependent), leading to a chronic, sustained activation of Nrf2.", "entity1": "Nrf2", "entity2": "arsenic", "span1": [126, 130], "span2": [6, 13]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4344": {"label": 3, "data": {"text": "Pinosylvin was also found to attenuate the activation of proteins involved in focal adhesion kinase (FAK)/c-Src/extracellular signal-regulated kinase (ERK) signaling, and phosphoinositide 3-kinase (PI3K)/Akt/ glycogen synthase kinase 3\u03b2 (GSK-3\u03b2) signaling pathway.", "entity1": "GSK-3\u03b2", "entity2": "Pinosylvin", "span1": [238, 244], "span2": [0, 10]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2336": {"label": 3, "data": {"text": "The Na channel block caused by lidocaine and RSD1235 can be through the open or inactivated states of the channel, but both equivalently inhibit a late component of Na current (I(Na)), recorded at 22 degrees C using whole-cell patch clamp of Nav 1.5 expressed in HEK cells.", "entity1": "Na channel", "entity2": "RSD1235", "span1": [4, 14], "span2": [45, 52]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14748": {"label": 3, "data": {"text": "Consistent with this, we found that knockdown of Pirh2 inhibits, whereas ectopic expression of Pirh2 enhances, arsenic-induced degradation of \u0394Np63 protein.", "entity1": "\u0394Np63", "entity2": "arsenic", "span1": [142, 147], "span2": [111, 118]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3088": {"label": 4, "data": {"text": "Unlike the sedative hypnotics that target GABA(A) receptor complexes, ramelteon is a chronohypnotic that acts on the melatonin MT(1) and MT(2) receptors, which are primarily located in the suprachiasmatic nucleus, the body's \"master clock.\"", "entity1": "MT(1)", "entity2": "ramelteon", "span1": [127, 132], "span2": [70, 79]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"12596": {"label": 0, "data": {"text": "The predicted structure of PHBP showed three epidermal growth factor (EGF) domains, a kringle domain and a serine protease domain, from its N-terminus, although HGFA has a fibronectin type II domain, an EGF domain, a fibronectin type I domain, an EGF domain, a kringle domain, and a serine protease domain, from its N-terminus.", "entity1": "epidermal growth factor (EGF) domains", "entity2": "N", "span1": [45, 82], "span2": [140, 141]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1838": {"label": 3, "data": {"text": "The activities of ABCA1 and other ATP binding cassette superfamily members are inhibited by the drug glyburide, and SR-BI-mediated lipid transport is blocked by small molecule inhibitors called BLTs.", "entity1": "ABCA1", "entity2": "glyburide", "span1": [18, 23], "span2": [101, 110]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"14076": {"label": 3, "data": {"text": "SB203580 (a specific inhibitor of p38 kinase) markedly suppressed the increased expression of collagen type I and \u03b1-SMA in TGF-\u03b21-induced NPDFs.", "entity1": "\u03b1-SMA", "entity2": "SB203580", "span1": [114, 119], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7309": {"label": 8, "data": {"text": "Here, we describe a new photolabile alanine derivative based on protection of alanine with the 4-methoxy-7-nitroindolinyl (MNI) caging group, which we use for pre-steady-state kinetic analysis of alanine transport by ASCT2, SNAT1, and SNAT2.", "entity1": "ASCT2", "entity2": "alanine", "span1": [217, 222], "span2": [78, 85]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"7534": {"label": 8, "data": {"text": "10), is an 18-kDa integral nuclear membrane protein that belongs to a superfamily of membrane-associated proteins in eicosanoid and glutathione metabolism that includes 5-lipoxygenase-activating protein, microsomal glutathione S-transferases (MGSTs), and microsomal prostaglandin E synthase 1 (ref.", "entity1": "microsomal prostaglandin E synthase 1", "entity2": "eicosanoid", "span1": [255, 292], "span2": [117, 127]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10670": {"label": 9, "data": {"text": "Antag I and Antag II did not alter oxytocin receptor number or binding affinity significantly at each time point studied compared with controls.", "entity1": "oxytocin receptor", "entity2": "Antag I", "span1": [35, 52], "span2": [0, 7]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"3871": {"label": 1, "data": {"text": "The glycogen synthase kinase-3\u03b2/nuclear factor-kappa B pathway is involved in cinobufagin-induced apoptosis in cultured osteosarcoma cells.", "entity1": "glycogen synthase kinase-3\u03b2", "entity2": "cinobufagin", "span1": [4, 31], "span2": [78, 89]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4554": {"label": 1, "data": {"text": "Alcohol modulates expression of DNA methyltranferases and methyl CpG-/CpG domain-binding proteins in murine embryonic fibroblasts.", "entity1": "DNA methyltranferases", "entity2": "Alcohol", "span1": [32, 53], "span2": [0, 7]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12573": {"label": 8, "data": {"text": "Glutathione-independent prostaglandin D synthase [prostaglandin-H2 D-isomerase; (5Z,13E)-(15S)-9 alpha,11 alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase, EC 5.3.99.2] is an enzyme responsible for biosynthesis of prostaglandin D2 in the central nervous system.", "entity1": "EC 5.3.99.2", "entity2": "prostaglandin D2", "span1": [165, 176], "span2": [223, 239]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13985": {"label": 0, "data": {"text": "PRINCIPAL FINDINGS: With the knowledge that all general anesthetics positively modulate GABA(A)-R-mediated inhibitory transmission, site-directed mutagenesis comparing sequences of GABA(A)-R subunits of varying sensitivity led to identification of amino acid residues in the transmembrane domain that are critical for the drug actions in vitro.", "entity1": "GABA(A)-R", "entity2": "amino acid", "span1": [181, 190], "span2": [248, 258]}, "weak_labels": [0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"395": {"label": 1, "data": {"text": "The region delineated by the fourth and fifth transmembrane helices of CB1 proved to be crucial for high affinity binding of SR 141716A.", "entity1": "CB1", "entity2": "SR 141716A", "span1": [71, 74], "span2": [125, 135]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2018": {"label": 3, "data": {"text": "The aim of this study was to determine the mechanism of pranlukast-induced interleukin-5 (IL-5) inhibition in allergic inflammation.", "entity1": "IL-5", "entity2": "pranlukast", "span1": [90, 94], "span2": [56, 66]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12483": {"label": 8, "data": {"text": "Cynomolgus FMO1, FMO2, FMO3, and FMO5 metabolized benzydamine, and FMO1/FMO3 and FMO3 also metabolized methimazole and trimethylamine, respectively.", "entity1": "FMO3", "entity2": "methimazole", "span1": [72, 76], "span2": [103, 114]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14627": {"label": 8, "data": {"text": "All four DCK proteins yielded comparable metabolic activity for Ara-C and dFdC monophosphorylation, except for DCK24Val, which demonstrated an approximately 2-fold increase (P < 0.05) in the intrinsic clearance of dFdC monophosphorylation due to a 40% decrease in K(m) (P < 0.05).", "entity1": "DCK", "entity2": "dFdC", "span1": [9, 12], "span2": [74, 78]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2589": {"label": 5, "data": {"text": "The non-selective adenosine receptor antagonist (caffeine), and the selective adenosine A1 receptor antagonist (DPCPX), injected 15 min before the application of pentetrazole and flumazenil, were able to intensify BDZ withdrawal signs in mice.", "entity1": "adenosine receptor", "entity2": "caffeine", "span1": [18, 36], "span2": [49, 57]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8683": {"label": 3, "data": {"text": "Recently, the c-Abl kinase inhibitor imatinib mesylate (imatinib) has become the focus of research as a fertoprotective drug against cisplatin.", "entity1": "kinase", "entity2": "imatinib mesylate", "span1": [20, 26], "span2": [37, 54]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11922": {"label": 3, "data": {"text": "The most potent in\u2005vitro DASI discovered is an imidazole derivative with IC50 values against aromatase and steroid sulfatase in a JEG-3 cell preparation of 0.2 and 2.5\u2005nM, respectively.", "entity1": "aromatase", "entity2": "imidazole", "span1": [93, 102], "span2": [47, 56]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2628": {"label": 3, "data": {"text": "We show that sorafenib (BAY 43-9006, Nexavar) potently inhibits FLT3 enzymatic and signaling activities.", "entity1": "FLT3", "entity2": "BAY 43-9006", "span1": [64, 68], "span2": [24, 35]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7567": {"label": 1, "data": {"text": "Compounds 1 and 2 potently displaced (3)H-NMS binding at m1, m3 and m4 receptors, but were less potent at the m2 and m5 subtypes.", "entity1": "m2", "entity2": "(3)H-NMS", "span1": [110, 112], "span2": [37, 45]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4470": {"label": 3, "data": {"text": "Catalpol reduced the expression of pro-inflammatory mediates, such as monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-\u03b1 (TNF-\u03b1), inducible NO synthase (iNOS), and receptor for AGE (RAGE).", "entity1": "receptor for AGE", "entity2": "Catalpol", "span1": [177, 193], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15305": {"label": 9, "data": {"text": "Catalase, glutathione-S-transferase and xanthine oxidase activities were not altered by atorvastatin treatment or withdrawal, as well as protein carbonyl and 4-hydroxy-2-nonenal immunoreactivity.", "entity1": "glutathione-S-transferase", "entity2": "atorvastatin", "span1": [10, 35], "span2": [88, 100]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"5960": {"label": 2, "data": {"text": "After loperamide administration ACTH levels fell to a nadir of 135 +/- 76 pg/ml, and then CRH was still able to induce an ACTH increase; the pattern of ACTH response to CRH was slightly delayed.", "entity1": "ACTH", "entity2": "loperamide", "span1": [122, 126], "span2": [6, 16]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13976": {"label": 1, "data": {"text": "The altered genes associated with chlorcyclizine-induced cleft palate included Wnt5a, Bmp2, Bmp4, Fgf10, Fgfr2, Msx1, and Insig1 but the magnitude of the change was relatively small (1.5- to 2-fold).", "entity1": "Fgf10", "entity2": "chlorcyclizine", "span1": [98, 103], "span2": [34, 48]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8872": {"label": 3, "data": {"text": "Phosphorylation of c-Src, which was shown to be activated by AhR ligands, was also increased by I3S and TCDD, and blocking of c-Src activity by 4-amino-5-(4-chlorophenyl)-7-(t-butyl) pyrazolo[3,4-d]pyrimidine (PP2) inhibited phosphorylation of both c-Src and STAT3, raising a possibility that stimulatory activities of I3S and TCDD on Th17 differentiation could be exerted via increased phosphorylation of c-Src, which in turn stimulates STAT3 activation.", "entity1": "STAT3", "entity2": "4-amino-5-(4-chlorophenyl)-7-(t-butyl) pyrazolo[3,4-d]pyrimidine", "span1": [259, 264], "span2": [144, 208]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14050": {"label": 2, "data": {"text": "Aspirin and metformin (an activator of AMPK) increased inhibition of mTOR and Akt, as well as autophagy in CRC cells.", "entity1": "AMPK", "entity2": "Aspirin", "span1": [39, 43], "span2": [0, 7]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2081": {"label": 3, "data": {"text": "These data demonstrated that 1) gemcitabine and pemetrexed synergistically interact against NSCLC cells through the suppression of Akt phosphorylation and induction of apoptosis; 2) the gene expression profile of critical genes may predict for drug chemosensitivity; and 3) pemetrexed enhances dCK and hENT1 expression, thus suggesting the role of gene-expression modulation for rational development of chemotherapy combinations.", "entity1": "Akt", "entity2": "pemetrexed", "span1": [131, 134], "span2": [48, 58]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8063": {"label": 3, "data": {"text": "Moreover, paclitaxel-induced ERCC1 protein and mRNA levels significantly decreased via the downregulation of p38 activity by either a p38 MAPK inhibitor SB202190 or p38 knockdown with specific small interfering RNA (siRNA).", "entity1": "p38", "entity2": "SB202190", "span1": [134, 137], "span2": [153, 161]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, 3, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1869": {"label": 3, "data": {"text": "Four prenylflavonoids, kurarinone ( 1), a chalcone of 1, kuraridin ( 2), kurarinol ( 3), kushenol H ( 4) and kushenol K ( 5) isolated from the roots of Sophora flavescens were investigated for their inhibitory effects on diacylglycerol acyltransferase (DGAT).", "entity1": "DGAT", "entity2": "kurarinone", "span1": [253, 257], "span2": [23, 33]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8241": {"label": 0, "data": {"text": "IKK phosphorylates BAD at serine-26 (Ser26) and primes it for inactivation.", "entity1": "BAD", "entity2": "serine", "span1": [19, 22], "span2": [26, 32]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"516": {"label": 4, "data": {"text": "Pre-clinical pharmacology of zolmitriptan (Zomig; formerly 311C90), a centrally and peripherally acting 5HT1B/1D agonist for migraine.", "entity1": "5HT1B/1D", "entity2": "Zomig", "span1": [104, 112], "span2": [43, 48]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12656": {"label": 1, "data": {"text": "Salicylic acid promotes dissociation of (125)I-ET-1 ETA receptor complexes both in the absence and the presence of unlabeled ET-1.", "entity1": "ET-1", "entity2": "(125)I", "span1": [125, 129], "span2": [40, 46]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8436": {"label": 1, "data": {"text": "The endogenous steroid lithocholic acid (LCA) dilates cerebral arteries via BK channel activation, which requires recognition by a BK \u03b21 site that includes Thr169.", "entity1": "BK channel", "entity2": "lithocholic acid", "span1": [76, 86], "span2": [23, 39]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9545": {"label": 1, "data": {"text": "In addition, the betaAR-mediated inhibition of IFN-gamma, GM-CSF, and IL-3 mRNA accumulation and GM-CSF protein secretion were related to the accumulation of intracellular cyclic adenosine monophosphate (cAMP) levels.", "entity1": "IFN-gamma", "entity2": "cyclic adenosine monophosphate", "span1": [47, 56], "span2": [172, 202]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7403": {"label": 2, "data": {"text": "Although considerable functional diversity exists, most C2 domains are activated by Ca2+ binding and then dock to a specific cellular membrane.", "entity1": "C2 domains", "entity2": "Ca2+", "span1": [56, 66], "span2": [84, 88]}, "weak_labels": [-1, -1, -1, 1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14357": {"label": 3, "data": {"text": "Met-RANTES treatment also reduced the levels of cathepsin K and metalloproteinase 13 (MMP13).", "entity1": "metalloproteinase 13", "entity2": "Met", "span1": [64, 84], "span2": [0, 3]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3441": {"label": 4, "data": {"text": "Differentiating the roles of mGlu2 and mGlu3 receptors using LY541850, an mGlu2 agonist/mGlu3 antagonist.", "entity1": "mGlu2", "entity2": "LY541850", "span1": [74, 79], "span2": [61, 69]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10908": {"label": 8, "data": {"text": "Pyridoxal kinase (PDXK) catalyzes the phosphorylation of pyridoxal, pyridoxamine, and pyridoxine in the presence of ATP and Zn2+.", "entity1": "PDXK", "entity2": "pyridoxamine", "span1": [18, 22], "span2": [68, 80]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"1856": {"label": 3, "data": {"text": "Some of these derivatives showed good inhibitory potency against two human CA isozymes involved in important physiological processes, CA I, and CA II, of the same order of magnitude as the clinically used drugs acetazolamide and methazolamide.", "entity1": "CA II", "entity2": "acetazolamide", "span1": [144, 149], "span2": [211, 224]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14202": {"label": 1, "data": {"text": "Galantamine is a reversible, competitive acetylcholinesterase (AChE) inhibitor and allosteric potentiating ligand of nicotinic acetylcholine receptors (nAChR-APL) that shares many common structural elements with morphinan-based opioids.", "entity1": "nAChR", "entity2": "Galantamine", "span1": [152, 157], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1]},
+	"15397": {"label": 1, "data": {"text": "p14ARF perturbs the androgen-induced interaction between the N terminus and C terminus of AR.", "entity1": "AR", "entity2": "androgen", "span1": [90, 92], "span2": [20, 28]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7644": {"label": 3, "data": {"text": "We found compounds that inhibited Panx1 currents with a rank order of potency: carbenoxolone > disodium 4,4'-diisothiocyanatostilbene-2,2'-disulfonate (DIDS) approximately disodium 4-acetamido-4'-isothiocyanato-stilben-2,2'-disulfonate approximately 5-nitro-2-(3-phenylpropylamino)benzoic acid > indanyloxyacetic acid 94 >> probenecid >> flufenamic acid = niflumic acid.", "entity1": "Panx1", "entity2": "flufenamic acid", "span1": [34, 39], "span2": [338, 353]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2400": {"label": 1, "data": {"text": "Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.", "entity1": "methionine aminopeptidase-2", "entity2": "anthranilic acid sulfonamides", "span1": [77, 104], "span2": [30, 59]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9805": {"label": 3, "data": {"text": "With respect to the quinone co-substrate of the dihydroorotate dehydrogenase, atovaquone (Kic = 2.7 microM) and dichloroally-lawsone (Kic = 9.8 nM) were shown to be competitive inhibitors of human dihydroorotate dehydrogenase.", "entity1": "human dihydroorotate dehydrogenase", "entity2": "dichloroally-lawsone", "span1": [191, 225], "span2": [112, 132]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"11400": {"label": 1, "data": {"text": "Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties.", "entity1": "potassium channel", "entity2": "Meclofenamic acid", "span1": [62, 79], "span2": [0, 17]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11104": {"label": 1, "data": {"text": "The endogenous ligand for imidazoline receptors may be a clonidine-displacing substance, a small molecule isolated from bovine brain.", "entity1": "imidazoline receptors", "entity2": "clonidine", "span1": [26, 47], "span2": [57, 66]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2262": {"label": 8, "data": {"text": "The concomitantly administered effects of rifampicin on other drugs can result in their altered metabolism or transportation that are metabolised by cytochromes P450 or transported by p-glycoprotein in the gastrointestinal tract and liver.", "entity1": "cytochromes P450", "entity2": "rifampicin", "span1": [149, 165], "span2": [42, 52]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"6295": {"label": 5, "data": {"text": "The selective 5-HT1A receptor antagonist, WAY100,635, slightly attenuated the (-)-pindolol-induced increase in DA and NAD levels, while the selective 5-HT1B antagonist, SB224,289, was ineffective.", "entity1": "5-HT1B", "entity2": "SB224,289", "span1": [150, 156], "span2": [169, 178]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4870": {"label": 4, "data": {"text": "Although generally highly specific for angiotensin II type 1 receptors, some ARBs, particularly telmisartan, are partial agonists at peroxisome proliferator-activated receptor-\u03b3.", "entity1": "peroxisome proliferator-activated receptor-\u03b3", "entity2": "telmisartan", "span1": [133, 177], "span2": [96, 107]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9436": {"label": 3, "data": {"text": "The alendronate inhibition of these three PTPs and two substrates is consistent with the formation of a ternary complex comprised of enzyme, substrate, and inhibitor.", "entity1": "PTPs", "entity2": "alendronate", "span1": [42, 46], "span2": [4, 15]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"16067": {"label": 1, "data": {"text": "Oral ibrutinib is indicated for the treatment of patients with relapsed/refractory mantle cell lymphoma (MCL) or chronic lymphocytic leukaemia (CLL) and for the treatment of patients with CLL and a chromosome 17 deletion (del 17p) or TP53 mutation.", "entity1": "TP53", "entity2": "ibrutinib", "span1": [234, 238], "span2": [5, 14]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13749": {"label": 1, "data": {"text": "(+)-[(3)H]isradipine binding to Ca(v)1.2DHP(-/-) and Ca(v)-DM brains was reduced to 15.1 and 4.4% of wild type, respectively, indicating that Ca(v)1.3 accounts for 10.7% of brain LTCCs.", "entity1": "Ca(v)1.3", "entity2": "(+)-[(3)H]isradipine", "span1": [142, 150], "span2": [0, 20]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3153": {"label": 4, "data": {"text": "Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity.", "entity1": "TrkA", "entity2": "Amitriptyline", "span1": [19, 23], "span2": [0, 13]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7795": {"label": 2, "data": {"text": "Reversal of inhibition by D2 agonist quinpirole was produced by serotonin (50 \u00b5M) and by neurotensin (5-10 nM).", "entity1": "D2", "entity2": "neurotensin", "span1": [26, 28], "span2": [89, 100]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, 4, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"3647": {"label": 1, "data": {"text": "PC12 cell apoptosis induced by DBDCT was confirmed by annexin V/propidium iodide staining, and characterized by cleavage of caspase-9 and caspase-3 proteins.", "entity1": "caspase-9", "entity2": "DBDCT", "span1": [124, 133], "span2": [31, 36]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8458": {"label": 3, "data": {"text": "Hinokitiol inhibited the phosphorylation of phospholipase C (PLC)\u03b32, protein kinase C (PKC), mitogen-activated protein kinases (MAPKs), and Akt in collagen-activated human platelets, and significantly reduced intracellular calcium mobilization and hydroxyl radical (OH) formation.", "entity1": "PKC", "entity2": "Hinokitiol", "span1": [87, 90], "span2": [0, 10]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7547": {"label": 3, "data": {"text": "Phenelzine (PLZ), a nonselective irreversible inhibitor of monoamine oxidase (MAO), also inhibits GABA-transaminase (GABA-T), markedly increasing brain GABA levels.", "entity1": "MAO", "entity2": "PLZ", "span1": [78, 81], "span2": [12, 15]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1817": {"label": 8, "data": {"text": "Our results indicate that Salix extract 1520L inhibits COX-2-mediated PGE2 release through compounds other than salicin or salicylate.", "entity1": "COX-2", "entity2": "PGE2", "span1": [55, 60], "span2": [70, 74]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12226": {"label": 2, "data": {"text": "EC50 values for S-(+)-METH were 0.89, 0.92, and 4.44 microM for rTAAR1, mTAAR1, and h-rChTAAR1, respectively.", "entity1": "mTAAR1", "entity2": "S-(+)-METH", "span1": [72, 78], "span2": [16, 26]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13729": {"label": 8, "data": {"text": "DNA damage is accepted as a consequence of thymidylate deprivation induced by chemotherapeutic inhibitors of thymidylate synthase (TS), but the types of damage and signaling responses remain incompletely understood.", "entity1": "TS", "entity2": "thymidylate", "span1": [131, 133], "span2": [43, 54]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15729": {"label": 4, "data": {"text": "These results indicate that parabens are selective agonists for ER\u03b2 over ER\u03b1; their interactions with ER\u03b1/\u03b2 are dependent on the size and bulkiness of the alkyl groups; and they are metabolized by carboxylesterases, leading to attenuation of their estrogenic activity.", "entity1": "ER\u03b2", "entity2": "parabens", "span1": [64, 67], "span2": [28, 36]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9921": {"label": 1, "data": {"text": "Serotonin transporter gene regulatory region polymorphism (5-HTTLPR), [3H]paroxetine binding in healthy control subjects and alcohol-dependent patients and their relationships to impulsivity.", "entity1": "5-HTTLPR", "entity2": "[3H]paroxetine", "span1": [59, 67], "span2": [70, 84]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"6343": {"label": 5, "data": {"text": "The mode of (functional) AT1 receptor antagonism has been characterized as surmountable/noncompetitive (losartan, tasosartan, eprosartan) or insurmountable/noncompetitive (candesartan, saprisartan, zolasartan, irbesartan, valsartan, telmisartan, E3174).", "entity1": "AT1", "entity2": "telmisartan", "span1": [25, 28], "span2": [233, 244]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8636": {"label": 9, "data": {"text": "Ovarian AR was not influenced by either treatment, and oviduct AR was reduced after ethanol-melatonin combination.", "entity1": "AR", "entity2": "ethanol", "span1": [8, 10], "span2": [84, 91]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"14555": {"label": 5, "data": {"text": "Within the TPBP scaffold, either electronic or steric perturbations to the central piperidine ring led to a loss of selective M(1) allosteric agonism and afforded pan-mAChR antagonism, which was demonstrated to be mediated via the orthosteric site.", "entity1": "mAChR", "entity2": "TPBP", "span1": [167, 172], "span2": [11, 15]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, 5, -1, 6, -1, -1, -1, -1, -1, -1, -1]},
+	"14014": {"label": 3, "data": {"text": "Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth.", "entity1": "VEGFR2", "entity2": "Cabozantinib", "span1": [38, 44], "span2": [0, 12]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7139": {"label": 1, "data": {"text": "All PDE5 constructs had similar affinities for 3-isobutyl-1-methylxanthine, sildenafil, tadalafil, and UK-122764, but mutants containing a complete GAF-B had 7- to 18-fold higher affinity for vardenafil-based compounds compared with those lacking a complete GAF-B.", "entity1": "GAF-B", "entity2": "vardenafil", "span1": [148, 153], "span2": [192, 202]}, "weak_labels": [-1, -1, 0, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10169": {"label": 1, "data": {"text": "This increased HDAC activity is then available for corticosteroid recruitment and predicts a cooperative interaction between corticosteroids and theophylline.", "entity1": "HDAC", "entity2": "corticosteroid", "span1": [15, 19], "span2": [51, 65]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7022": {"label": 3, "data": {"text": "Competitive radioligand binding assays were performed using cells expressing either the human serotonin (5-HT) transporter (hSERT) or norepinephrine (NE) transporter (hNET) with K(i) values for DVS of 40.2 +/- 1.6 and 558.4 +/- 121.6 nM, respectively.", "entity1": "norepinephrine (NE) transporter", "entity2": "DVS", "span1": [134, 165], "span2": [194, 197]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"10554": {"label": 1, "data": {"text": "[3H]DMI trapped in membranes was displaceable by the structurally unrelated NET inhibitor, nisoxetine, in a concentration-dependent manner, implying interaction of retained [3H]DMI with the NET.", "entity1": "NET", "entity2": "[3H]DMI", "span1": [190, 193], "span2": [173, 180]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5894": {"label": 3, "data": {"text": "Mouse ornithine decarboxylase (ODC) was expressed in Escherichia coli and the purified recombinant enzyme used for determination of the binding site for pyridoxal 5'-phosphate and of the residues modified in the inactivation of the enzyme by the enzyme-activated irreversible inhibitor, alpha-difluoromethylornithine (DFMO).", "entity1": "ODC", "entity2": "DFMO", "span1": [31, 34], "span2": [318, 322]}, "weak_labels": [-1, -1, -1, 1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11495": {"label": 3, "data": {"text": "RESULTS: Ketorolac was six times more active against COX-1 (IC(50) = 0.02 microM) than COX-2 (IC(50) = 0.12 microM) while bromfenac was approximately 32 times more active against COX-2 (IC(50) = 0.0066 microM) than COX-1 (IC(50) = 0.210 microM).", "entity1": "COX-2", "entity2": "Ketorolac", "span1": [179, 184], "span2": [9, 18]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13391": {"label": 2, "data": {"text": "In summary, phenformin and metformin increase AMPK activity and phosphorylation in the isolated heart.", "entity1": "AMPK", "entity2": "metformin", "span1": [46, 50], "span2": [27, 36]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"165": {"label": 3, "data": {"text": "Acetylcholinesterase (AChE) inhibited by the organophosphate soman (1,2,2-trimethyl-propylmethylphosphonofluoridate) rapidly becomes resistant to reactivation by oximes due to dealkylation of the soman-enzyme complex.", "entity1": "AChE", "entity2": "soman", "span1": [22, 26], "span2": [61, 66]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6371": {"label": 4, "data": {"text": "The mu-opioid receptor-selective agonist lofentanil potently and competitively displaced [3H]nociceptin at rat brain receptors (IC(50) 62 nM).", "entity1": "mu-opioid receptor", "entity2": "lofentanil", "span1": [4, 22], "span2": [41, 51]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15453": {"label": 3, "data": {"text": "Of the compounds active in the present assay system, the most potent compound 7, platyphyllonol-5-O-\u03b2-d-xylopyranoside, significantly suppressed the induction of peroxisome proliferator activated receptor \u03b3 (PPAR\u03b3 and CCAAT/enhancer binding protein \u03b1 (C/EBP\u03b1) protein expression, and inhibited adipocyte differentiation induced by troglitazone, a PPAR\u03b3 agonist.", "entity1": "C/EBP\u03b1", "entity2": "platyphyllonol-5-O-\u03b2-d-xylopyranoside", "span1": [252, 258], "span2": [81, 118]}, "weak_labels": [-1, -1, -1, 1, -1, -1, 2, -1, 2, -1, -1, -1, -1, 3, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9561": {"label": 2, "data": {"text": "The observed inhibition on IFN-gamma, GM-CSF, and IL-3 mRNA was blocked by the selective beta2AR antagonist ICI 118,551 (10(-6) M) and by timolol (10(-6) M), a nonselective antagonist.", "entity1": "IL-3", "entity2": "ICI 118,551", "span1": [50, 54], "span2": [108, 119]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13429": {"label": 2, "data": {"text": "D-glucose stimulation of L-arginine transport and nitric oxide synthesis results from activation of mitogen-activated protein kinases p42/44 and Smad2 requiring functional type II TGF-beta receptors in human umbilical vein endothelium.", "entity1": "Smad2", "entity2": "D-glucose", "span1": [145, 150], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"3623": {"label": 4, "data": {"text": "Direct-acting CB1 agonists, including \u0394(9)-tetrahydrocannabinol, WIN 55,212 [R-(1)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone mesylate], AM2389 [9\u03b2-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol], and AM4054 [9\u03b2-(hydroxymethyl)-3-(1-adamantyl)-hexahydrocannabinol], produced dose-dependent increases in diuresis and decreases in colonic temperature, with slightly lower ED(50) values for diuresis than for hypothermia.", "entity1": "CB1", "entity2": "9\u03b2-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol", "span1": [14, 17], "span2": [209, 265]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, 4, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"14125": {"label": 1, "data": {"text": "Crizotinib is an oral tyrosine kinase inhibitor (TKI), which silences the protein product of the ALK fusion gene and has recently been approved for the treatment of NSCLC aberrantly expressing ALK.", "entity1": "ALK", "entity2": "Crizotinib", "span1": [193, 196], "span2": [0, 10]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"6001": {"label": 3, "data": {"text": "Whole-cell voltage-clamp of hNET-293 cells reveals NE-induced, Na(+)-dependent currents blocked by antidepressants and cocaine that are absent in parental cells.", "entity1": "hNET", "entity2": "cocaine", "span1": [28, 32], "span2": [119, 126]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"667": {"label": 3, "data": {"text": "OBJECTIVE: To evaluate the extent of human cyclooxygenase-1 (COX-1) inhibition by meloxicam, which has been reported to preferentially inhibit cyclooxygenase-2 (COX-2).", "entity1": "cyclooxygenase-2", "entity2": "meloxicam", "span1": [143, 159], "span2": [82, 91]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12106": {"label": 3, "data": {"text": "HERG/IKr channels are a prime target for the pharmacological management of arrhythmias and are selectively blocked by class III antiarrhythmic methanesulfonanilide drugs, such as dofetilide, E4031, and MK-499, at submicromolar concentrations.", "entity1": "IKr", "entity2": "MK-499", "span1": [5, 8], "span2": [202, 208]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10311": {"label": 1, "data": {"text": "The yohimbine dimers n = 3 and n = 24 showed the highest potency and selectivity (32- and 82-fold. respectively) for the alpha2C-adrenoceptor in receptor binding and in functional studies (42- and 29-fold, respectively) measuring cAMP changes using a cell-based luciferase reporter gene assay.", "entity1": "alpha2C-adrenoceptor", "entity2": "yohimbine", "span1": [121, 141], "span2": [4, 13]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12537": {"label": 1, "data": {"text": "Certain of the adenosine conjugates are highly selective for A1 receptors.", "entity1": "A1 receptors", "entity2": "adenosine", "span1": [61, 73], "span2": [15, 24]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2624": {"label": 8, "data": {"text": "Adenine phosphoribosyltransferase plays a role in purine salvage by catalyzing the direct conversion of adenine to adenosine monophosphate.", "entity1": "Adenine phosphoribosyltransferase", "entity2": "adenine", "span1": [0, 33], "span2": [104, 111]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, 8, -1]},
+	"8188": {"label": 3, "data": {"text": "Consistent with zinc finger E-box binding homeobox 2, which was confirmed as a direct target of miR-200b in endometrial cancer cell lines, some other key factors of EMT such as Snail and N-cadherin increased, whereas E-cadherin decreased in the TAM-treated cells, contributing to TAM-induced EMT in these endometrial cancer cells.", "entity1": "E-cadherin", "entity2": "TAM", "span1": [217, 227], "span2": [245, 248]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7699": {"label": 8, "data": {"text": "The progress of the enzymatic reaction of the hydrolysis of acetylthiocholine at pH 8 in the presence of AChE and the inhibitor studied is determined by measuring at 230 nm the peak area of the reaction product thiocholine (TCh).", "entity1": "AChE", "entity2": "acetylthiocholine", "span1": [105, 109], "span2": [60, 77]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"5477": {"label": 1, "data": {"text": "At 37 degrees C the relative affinity of 3-keto-desogestrel, the major metabolite of desogestrel, for the progesterone receptor in intact MCF-7 cells was twice that of levonorgestrel and Org 2058, three times that of medroxy-progesterone acetate (MPA), 4.5 times that of norethisterone and 5 times that of progesterone and cyproterone acetate whereas at 4 degrees C in the cytosol fraction of MCF-7 cells exposed to molybdate (nontransformed receptor complexes) 3-keto-desogestrel and Org 2058 displayed similar affinity.", "entity1": "progesterone receptor", "entity2": "cyproterone acetate", "span1": [106, 127], "span2": [323, 342]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7787": {"label": 3, "data": {"text": "Both apo-lycopenoic acids also decreased CSE-induced ROS production, 8-OHdG formation and reduced the increase in NOX-4 and COX-2 expressions caused by CSE.", "entity1": "NOX-4", "entity2": "apo-lycopenoic acids", "span1": [114, 119], "span2": [5, 25]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, 3, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"3826": {"label": 3, "data": {"text": "Structural optimization of 2,5-thiophene amides as highly potent and selective 17\u03b2-hydroxysteroid dehydrogenase type 2 inhibitors for the treatment of osteoporosis.", "entity1": "17\u03b2-hydroxysteroid dehydrogenase type 2", "entity2": "2,5-thiophene amides", "span1": [79, 118], "span2": [27, 47]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14851": {"label": 2, "data": {"text": "Interestingly, Acrolein increased proteins' levels of amyloid precursor protein (APP), \u03b2-secretase (BACE-1) and the amyloid \u03b2-peptide transporter receptor for advanced glycation end products, and decreased A-disintegrin and metalloprotease (ADAM) 10 levels.", "entity1": "\u03b2-secretase", "entity2": "Acrolein", "span1": [87, 98], "span2": [15, 23]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, 8, -1, 8, -1, -1]},
+	"3277": {"label": 3, "data": {"text": "Using a unique biosensor-based assay, trifluoperazine (TFP) was identified as an inhibitor that disrupts the S100A4/myosin-IIA interaction.", "entity1": "myosin-IIA", "entity2": "TFP", "span1": [116, 126], "span2": [55, 58]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6171": {"label": 3, "data": {"text": "Selegiline (deprenyl), a selective, irreversible inhibitor of monoamine oxidase type B (MAO-B) is widely used in the treatment of Parkinson's disease.", "entity1": "monoamine oxidase type B", "entity2": "deprenyl", "span1": [62, 86], "span2": [12, 20]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5971": {"label": 3, "data": {"text": "However, betaxolol produces less systemic beta 2- and possibly beta 1-adrenergic receptor blockade than either timolol or levobunolol.", "entity1": "beta 1-adrenergic receptor", "entity2": "levobunolol", "span1": [63, 89], "span2": [122, 133]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"10034": {"label": 3, "data": {"text": "Rofecoxib is a selective cyclo-oxygenase (COX)-2 inhibitor which has little or no effect on the COX-1 isoenzyme at doses up to 1000 mg/day.", "entity1": "cyclo-oxygenase (COX)-2", "entity2": "Rofecoxib", "span1": [25, 48], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1844": {"label": 8, "data": {"text": "Here, we show that one BLT, [1-(2-methoxy-phenyl)-3-naphthalen-2-yl-urea] (BLT-4), blocked ABCA1-mediated cholesterol efflux to lipid-poor apoA-I at a potency similar to that for its inhibition of SR-BI (IC(50) approximately 55-60 microM).", "entity1": "ABCA1", "entity2": "cholesterol", "span1": [91, 96], "span2": [106, 117]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8678": {"label": 3, "data": {"text": "While imatinib was unable to block cisplatin-induced DNA damage and damage response, such as the upregulation of p53, imatinib inhibited the cisplatin-induced nuclear accumulation of c-Abl/TAp73 and the subsequent downregulation of TAp63 and upregulation of Bax, thereby abrogating oocyte cell death.", "entity1": "c-Abl", "entity2": "imatinib", "span1": [183, 188], "span2": [118, 126]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, 2, 3, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7089": {"label": 3, "data": {"text": "These currents were produced by glutamate-aspartate transporters (GLAST) (excitatory amino acid transporter 1) because they were weakly inhibited by dihydrokainate, an antagonist of glutamate transporter-1 (excitatory amino acid transporter 2) and were absent from IPCs in GLAST-/- cochleas.", "entity1": "excitatory amino acid transporter 1", "entity2": "dihydrokainate", "span1": [74, 109], "span2": [149, 163]}, "weak_labels": [0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, 5, -1, -1, -1, -1, 8, -1, 8, -1, -1]},
+	"11542": {"label": 3, "data": {"text": "Repression of HDC gene expression and HDC activity by dexamethasone may underlie its therapeutic effect in the treatment of allergy.", "entity1": "HDC", "entity2": "dexamethasone", "span1": [14, 17], "span2": [54, 67]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"167": {"label": 3, "data": {"text": "Acetylcholinesterase (AChE) inhibited by the organophosphate soman (1,2,2-trimethyl-propylmethylphosphonofluoridate) rapidly becomes resistant to reactivation by oximes due to dealkylation of the soman-enzyme complex.", "entity1": "AChE", "entity2": "1,2,2-trimethyl-propylmethylphosphonofluoridate", "span1": [22, 26], "span2": [68, 115]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6335": {"label": 1, "data": {"text": "Among the current AT1 receptor antagonists, the rank order of the relative binding affinities (highest affinity = 1) is: candesartan 1, telmisartan 10, E3174 (the active metabolite of losartan) 10, tasosartan 20, losartan 50, eprosartan 100 and the prodrug candesartan cilexetil 280.", "entity1": "AT1", "entity2": "E3174", "span1": [18, 21], "span2": [152, 157]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11613": {"label": 2, "data": {"text": "Our data identify cAspAT as a new member of glyceroneogenesis, transcriptionally regulated by TZD via the control of RORalpha expression by PPARgamma in adipocytes.", "entity1": "cAspAT", "entity2": "TZD", "span1": [18, 24], "span2": [94, 97]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8328": {"label": 2, "data": {"text": "The Paeoniflorin-induced HO-1 expression was abrogated by Nrf2 siRNA.", "entity1": "HO-1", "entity2": "Paeoniflorin", "span1": [25, 29], "span2": [4, 16]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10203": {"label": 8, "data": {"text": "Rifampicin (10 micromol/L) inhibited OATP8-mediated BSP uptake by 50%, whereas inhibition of OATP-C-, OATP-B-, and OATP-A-mediated BSP transport was below 15%.", "entity1": "OATP-C", "entity2": "BSP", "span1": [93, 99], "span2": [131, 134]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"6726": {"label": 3, "data": {"text": "Compounds of several other structural families, including the quinoxaline AG1296, the bis(1H-2-indolyl)-1-methanone D-65476, the indolinones SU5416 and SU11248, the indolocarbazoles PKC412 and CEP-701, and the piperazonyl quinazoline CT53518, are potent inhibitors of Flt3 kinase.", "entity1": "Flt3", "entity2": "indolinones", "span1": [268, 272], "span2": [129, 140]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"260": {"label": 1, "data": {"text": "A phenomenological analysis of thermodynamic data showed that the amide substrates and p-ABZ interactions with zeta-thrombin were respectively, associated with a chemical compensation (i.e.", "entity1": "zeta-thrombin", "entity2": "p-ABZ", "span1": [111, 124], "span2": [87, 92]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"15317": {"label": 4, "data": {"text": "Moreover, the effects of the DRD3 agonist 7-hydroxy-N,N-dipropyl-2-aminotetralin (7-OH-DPAT)-induced locomotor hypoactivity were significantly increased when DRD3 proteins were abundant.", "entity1": "DRD3", "entity2": "7-OH-DPAT", "span1": [158, 162], "span2": [82, 91]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"8186": {"label": 2, "data": {"text": "Collectively, our data suggest that TAM can repress the miR-200 family and induce EMT via the up-regulation of c-Myc in endometrial cancer cells.", "entity1": "c-Myc", "entity2": "TAM", "span1": [111, 116], "span2": [36, 39]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10852": {"label": 3, "data": {"text": "Imatinib (STI571, Gleevec, Glivec; Novartis Pharmaceuticals, East Hanover, NJ), a selective inhibitor of KIT, ABL, BCR-ABL, PDGFRA, and PDGFRB, represents a new paradigm of targeted cancer therapy and has revolutionized the treatment of patients with chronic myelogenous leukemia and GISTs.", "entity1": "BCR", "entity2": "Glivec", "span1": [115, 118], "span2": [27, 33]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4877": {"label": 1, "data": {"text": "Chromatin immunoprecipitation (IP) revealed that methyl-CpG binding protein 2 (Mecp2) bound the glut3-(m)CpGs.", "entity1": "glut3", "entity2": "(m)CpGs", "span1": [96, 101], "span2": [102, 109]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11534": {"label": 1, "data": {"text": "Dopamine D2 receptor occupancy by risperidone: implications for the timing and magnitude of clinical response.", "entity1": "Dopamine D2 receptor", "entity2": "risperidone", "span1": [0, 20], "span2": [34, 45]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1822": {"label": 3, "data": {"text": "To investigate the mechanism and consequences of inhibition of QR2 by the quinolines further, we have used steady-state and transient-state kinetics to define the mechanism of QR2.", "entity1": "QR2", "entity2": "quinolines", "span1": [176, 179], "span2": [74, 84]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9541": {"label": 3, "data": {"text": "Lintitript markedly increased postprandial plasma CCK release (P<0.001) while distinctly reducing postprandial PP levels (P<0.01) as compared to placebo.", "entity1": "PP", "entity2": "Lintitript", "span1": [111, 113], "span2": [0, 10]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1637": {"label": 3, "data": {"text": "However, when naloxone was administered concurrently with ethanol treatment, it antagonized the down-regulation of p-CREB protein in the nucleus accumbens (142 %) of rats exposed to ethanol.", "entity1": "p-CREB", "entity2": "ethanol", "span1": [115, 121], "span2": [182, 189]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3015": {"label": 3, "data": {"text": "Inhibitors of PDE4 (rolipram; 0.1-10 microM) and PDE3 (cilostazol; 0.1-10 microM) delayed spontaneous eosinophil apoptosis maximally by 25% and 15%, respectively.", "entity1": "PDE3", "entity2": "cilostazol", "span1": [49, 53], "span2": [55, 65]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12383": {"label": 0, "data": {"text": "Similarly, mature BMP-2 was also cleaved to a truncated peptide within its N-terminal region (Arg(289)\u2193Lys(290)).", "entity1": "BMP-2", "entity2": "Arg", "span1": [18, 23], "span2": [94, 97]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11913": {"label": 1, "data": {"text": "We studied accumulation of lipid metabolites [triglycerides (TAGs), diglycerides (DAGs)] and ceramides in relation to insulin signaling and expression and phosphorylation of PTP1B by preincubating rat skeletal muscle cells (L6 myotubes) with three saturated and three unsaturated free fatty acids (FFAs) (200 \u03bcM).", "entity1": "insulin", "entity2": "TAGs", "span1": [118, 125], "span2": [61, 65]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1181": {"label": 3, "data": {"text": "Nateglinide inhibits Kir6.2/SUR1 and Kir6.2/SUR2B channels at 100 nM, and inhibits Kir6.2/SUR2A channels at high concentrations (1 microM).", "entity1": "Kir6.2", "entity2": "Nateglinide", "span1": [83, 89], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15767": {"label": 1, "data": {"text": "Both ICI treatments, induced a significant decrease (p<0.01) in uterine estrogen receptor alpha (ER\u03b1) content, had no effect on uterine progesterone receptor (PR) protein expression and caused marked nuclear localization of cyclin D1, in both luminal and glandular uterine epithelium, as compared to vehicle-treated animals.", "entity1": "cyclin D1", "entity2": "ICI", "span1": [224, 233], "span2": [5, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11569": {"label": 8, "data": {"text": "Specificity of zebrafish retinol saturase: formation of all-trans-13,14-dihydroretinol and all-trans-7,8- dihydroretinol.", "entity1": "zebrafish retinol saturase", "entity2": "all-trans-7,8- dihydroretinol", "span1": [15, 41], "span2": [91, 120]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3279": {"label": 3, "data": {"text": "Assays examining the ability of TFP to block S100A4-mediated disassembly of myosin-IIA filaments demonstrate that significant inhibition of S100A4 function occurs only at TFP concentrations that promote S100A4 oligomerization.", "entity1": "S100A4", "entity2": "TFP", "span1": [45, 51], "span2": [32, 35]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1424": {"label": 1, "data": {"text": "Preclinical studies demonstrate that the therapeutic activity of citalopram resides in the S-isomer and that escitalopram binds with high affinity to the human serotonin transporter.", "entity1": "human serotonin transporter", "entity2": "escitalopram", "span1": [154, 181], "span2": [109, 121]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"14760": {"label": 2, "data": {"text": "Jaceosidin, isolated from dietary mugwort (Artemisia princeps), induces G2/M cell cycle arrest by inactivating cdc25C-cdc2 via ATM-Chk1/2 activation.", "entity1": "ATM", "entity2": "Jaceosidin", "span1": [127, 130], "span2": [0, 10]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6125": {"label": 8, "data": {"text": "Amezinium and debrisoquine are substrates of uptake1 and potent inhibitors of monoamine oxidase in perfused lungs of rats.", "entity1": "uptake1", "entity2": "Amezinium", "span1": [45, 52], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"13735": {"label": 8, "data": {"text": "Nicotinamide N-methyltransferase (NNMT) catalyses the conversion of nicotinamide to 1-methylnicotinamide and plays an important role in hepatic detoxification reactions.", "entity1": "NNMT", "entity2": "1-methylnicotinamide", "span1": [34, 38], "span2": [84, 104]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, 8, -1]},
+	"14624": {"label": 8, "data": {"text": "All three CDA proteins showed similar K(m) and V(max) for Ara-C and dFdC deamination, except for CDA70Thr, which had a 2.5-fold lower K(m) and 6-fold lower V(max) for Ara-C deamination.", "entity1": "CDA", "entity2": "dFdC", "span1": [10, 13], "span2": [68, 72]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7584": {"label": 3, "data": {"text": "The direct inhibition of stathmin by CCNU is likely a contributing factor.", "entity1": "stathmin", "entity2": "CCNU", "span1": [25, 33], "span2": [37, 41]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1584": {"label": 3, "data": {"text": "The acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities of a series of pyrano[2,3-b]quinolines (2, 3), [1,8]naphthyridines (5, 6), 4-amino-2,3-diaryl-5,6,7,8-tetrahydrofuro[2,3-b]quinolines (11-13)/ 4-amino-6,7,8,9-tetrahydro-2,3-diphenyl-5H-cyclohepta[e]furo[2,3-b]pyridine (14), 4-amino-5,6,7,8-tetrahydro-2,3-diphenylthieno[2,3-b]quinoline (15)/ 4-amino-6,7,8,9-tetrahydro-2,3-diphenyl-5H-cyclohepta[e]thieno[2,3-b]pyridine (16) are described.", "entity1": "butyrylcholinesterase", "entity2": "4-amino-6,7,8,9-tetrahydro-2,3-diphenyl-5H-cyclohepta[e]furo[2,3-b]pyridine", "span1": [36, 57], "span2": [231, 306]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5331": {"label": 1, "data": {"text": "Few targets like epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) gene rearrangements have successfully been targeted with EGFR tyrosine kinase inhibitors (TKIs) and crizotinib, respectively.", "entity1": "ALK", "entity2": "crizotinib", "span1": [99, 102], "span2": [204, 214]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2785": {"label": 2, "data": {"text": "Intravenous arginine significantly increased the acute glucagon response (129 +/- 12 vs 36 +/- 6 ng/l in controls; p < 0.01), notably without affecting plasma glucose.", "entity1": "glucagon", "entity2": "arginine", "span1": [55, 63], "span2": [12, 20]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"12779": {"label": 1, "data": {"text": "Thymidylate synthase (TS) continues to be a critical target for 5-fluorouracil (5-FU) and its prodrugs, UFT/LV (Orzel), capecitabine (Xeloda), and S-1, primarily because this enzyme is essential for the synthesis of 2-deoxythymidine-5-monophosphate, a precursor for DNA synthesis.", "entity1": "Thymidylate synthase", "entity2": "Xeloda", "span1": [0, 20], "span2": [134, 140]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11169": {"label": 3, "data": {"text": "Our findings suggest that torasemide blocks the vasoconstrictor action of Ang II in vitro.", "entity1": "Ang II", "entity2": "torasemide", "span1": [74, 80], "span2": [26, 36]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2921": {"label": 3, "data": {"text": "Existing ion channel blockers, such as amiodarone, dronedarone, bepridil, aprindine, and cibenzoline, have been found to have an NCX inhibitory action.", "entity1": "NCX", "entity2": "dronedarone", "span1": [129, 132], "span2": [51, 62]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8703": {"label": 2, "data": {"text": "Arsenic upregulates the expression of angiotensin II Type I receptor in mouse aortic endothelial cells.", "entity1": "angiotensin II Type I receptor", "entity2": "Arsenic", "span1": [38, 68], "span2": [0, 7]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8291": {"label": 9, "data": {"text": "LY294002, a specific PI3K/AKT inhibitor, selectively activated the p38 MAPK kinase pathway and enhanced c-Jun phosphorylation, but did not activate JNK.", "entity1": "JNK", "entity2": "LY294002", "span1": [148, 151], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"12136": {"label": 2, "data": {"text": "The ensemble of results suggests that the ability of Sch B pretreatment to enhance hepatocellular DTD activity may at least in part be attributed to the protection against menadione hepatotoxicity.", "entity1": "DTD", "entity2": "Sch B", "span1": [98, 101], "span2": [53, 58]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12916": {"label": 8, "data": {"text": "Hydrogen sulfide (H(2)S), a regulatory gaseous molecule that is endogenously synthesized by cystathionine gamma-lyase (CSE) and/or cystathionine beta-synthase (CBS) from L-cysteine (L-Cys) metabolism, is a putative vasodilator, and its role in nitric oxide (NO) production is unexplored.", "entity1": "cystathionine gamma-lyase", "entity2": "H(2)S", "span1": [92, 117], "span2": [18, 23]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"7748": {"label": 0, "data": {"text": "Whole-exome analysis of the Pik3ca(H1047R)-driven mammary tumors identified multiple mutations, including Trp53 mutations that appeared spontaneously during the development of adenocarinoma and spindle cell tumors.", "entity1": "Pik3ca", "entity2": "Trp", "span1": [28, 34], "span2": [106, 109]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9209": {"label": 1, "data": {"text": "We have found that certain naphthalenesulfonamides [e.g., N-6(-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7)] and phenothiazines [e.g., trifluoperazine (TFP)] induce a loss of cell-surface receptors for alpha 2-macroglobulin, and epidermal growth factor (EGF) in fibroblasts.", "entity1": "alpha 2-macroglobulin", "entity2": "phenothiazines", "span1": [209, 230], "span2": [120, 134]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"11504": {"label": 0, "data": {"text": "New data for cattle (Bos taurus) indicates a gene encoding GnRH-II decapeptide possessing arginine (codon: CGG) rather than tryptophan (TGG) at position three in the mature peptide.", "entity1": "GnRH-II", "entity2": "CGG", "span1": [59, 66], "span2": [107, 110]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13077": {"label": 8, "data": {"text": "Methylthioadenosine phosphorylase (MTAP) salvages purines by releasing adenine from methylthioadenosine and is often deleted in mesothelioma.", "entity1": "Methylthioadenosine phosphorylase", "entity2": "methylthioadenosine", "span1": [0, 33], "span2": [84, 103]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15568": {"label": 3, "data": {"text": "In addition to the effect on ROS, puerarin ameliorated MPTP-reduced lysosome-associated membrane protein type 2A (Lamp 2A) expression.", "entity1": "lysosome-associated membrane protein type 2A", "entity2": "MPTP", "span1": [68, 112], "span2": [55, 59]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4412": {"label": 6, "data": {"text": "Using cell-based assays and brain slice preparations, we characterized the interaction of a potent and efficacious mGlu5 PAM from the CPPHA series termed NCFP (N-(4-chloro-2-((4-fluoro-1,3-dioxoisoindolin-2-yl)methyl)phenyl)picolinamide).", "entity1": "mGlu5", "entity2": "NCFP", "span1": [115, 120], "span2": [154, 158]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6362": {"label": 8, "data": {"text": "Quinone oxidoreductases are flavoproteins that catalyze two-electron reduction and detoxification of quinones.", "entity1": "Quinone oxidoreductases", "entity2": "quinones", "span1": [0, 23], "span2": [101, 109]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"4789": {"label": 3, "data": {"text": "Lineweaver-Burk plots demonstrated that baicalin inhibited the activities of CYP2D and CYP3A in a non-competitive manner in rat liver microsomes (RLMs).", "entity1": "CYP3A", "entity2": "baicalin", "span1": [87, 92], "span2": [40, 48]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8632": {"label": 2, "data": {"text": "Thus, arsenic activates Nrf2 through a non-canonical mechanism (p62-dependent), leading to a chronic, sustained activation of Nrf2.", "entity1": "Nrf2", "entity2": "arsenic", "span1": [24, 28], "span2": [6, 13]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14380": {"label": 3, "data": {"text": "Furthermore, the EGFR inhibitor AG1478 inhibited EGF-induced MMP-9 expression, cell migration and invasion, as well as the activation of PI3K/Akt, suggesting that PI3K/Akt activation occur downstream of EGFR activation.", "entity1": "PI3K", "entity2": "AG1478", "span1": [163, 167], "span2": [32, 38]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9674": {"label": 3, "data": {"text": "We find that FP causes a decrease in stimulated eosinophil secretion of LTC4 that is regulated by phospholipase A2 (PLA2).", "entity1": "phospholipase A2", "entity2": "FP", "span1": [98, 114], "span2": [13, 15]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12755": {"label": 2, "data": {"text": "The ratio of TGF-beta1 absorbed light value to GAPDH absorbed light value in the SHR group was 0.887+/-0.019, which was significantly higher than that in WKY group, imidapril group, and irbesartan group with the ratios of 0.780+/-0.018, 0.803+/-0.005, and 0.847+/-0.017, respectively (P<0.01).", "entity1": "TGF-beta1", "entity2": "imidapril", "span1": [13, 22], "span2": [165, 174]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9352": {"label": 0, "data": {"text": "Single-strand conformational analysis and nucleotide sequencing of the entire coding region of the PC3 gene in 102 Japanese subjects with NIDDM revealed missense mutations in exons 2 (Arg/Gln53) and 14 (Gln/Glu638), neither of which was associated with NIDDM in this population.", "entity1": "PC3", "entity2": "nucleotide", "span1": [99, 102], "span2": [42, 52]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2151": {"label": 1, "data": {"text": "2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors.", "entity1": "CXCR1", "entity2": "2-Arylpropionic", "span1": [42, 47], "span2": [0, 15]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3815": {"label": 0, "data": {"text": "Binding of the agonist angiotensin II (AngII) and inverse agonist losartan in wild-type AT1R changed the accessibility of reporter cysteines, and the pattern was consistent with ligand-specific \"lid\" conformations of ECL2.", "entity1": "AT1R", "entity2": "cysteines", "span1": [88, 92], "span2": [131, 140]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15662": {"label": 3, "data": {"text": "We have identified 3-hydroxypyridin-2-thione (3-HPT) as a novel ZBG that is compatible with HDAC inhibition.", "entity1": "HDAC", "entity2": "3-HPT", "span1": [92, 96], "span2": [46, 51]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1961": {"label": 3, "data": {"text": "To explore for the existence of an auxiliary hydrophobic binding register remote from the active site of PSMA a series of phenylalkylphosphonamidate derivatives of glutamic acid were synthesized and evaluated for their inhibitory potencies against PSMA.", "entity1": "PSMA", "entity2": "glutamic acid", "span1": [248, 252], "span2": [164, 177]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4096": {"label": 3, "data": {"text": "The upregulation of calpain, tBid and caspase-3 activity were further inhibited by treatment with EGTA in the presence of ALD.", "entity1": "calpain", "entity2": "EGTA", "span1": [20, 27], "span2": [98, 102]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1218": {"label": 3, "data": {"text": "Also in contrast to effects of multiple METH injections, 1) MDMA caused little or no decrease in binding of the DAT ligand WIN35428, and 2) neither prevention of hyperthermia nor prior depletion of DA prevented the MDMA-induced reduction in plasmalemmal DA transport.", "entity1": "DAT", "entity2": "METH", "span1": [112, 115], "span2": [40, 44]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, 3, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"14043": {"label": 3, "data": {"text": "We have examined the effectiveness of two novel Chk1 selective inhibitors, AR323 and AR678, in a panel of melanoma cell lines and normal cell types.", "entity1": "Chk1", "entity2": "AR678", "span1": [48, 52], "span2": [85, 90]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9192": {"label": 2, "data": {"text": "This agent acts synergistically with many penicillins, such as ampicillin, carbenicillin, and the like, and with cephalosporins, cefazolin, cefamandole, or cefoxitin to inhibit gram-negative bacilli, probably on the basis of binding to different proteins needed for the production of the peptidoglycan of the bacterial cell wall.", "entity1": "peptidoglycan", "entity2": "cefamandole", "span1": [288, 301], "span2": [140, 151]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"2732": {"label": 2, "data": {"text": "Under isotonic conditions, N-ethylmaleimide (NEM) produced KCC activation and transient cell shrinkage.", "entity1": "KCC", "entity2": "NEM", "span1": [59, 62], "span2": [45, 48]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"1216": {"label": 1, "data": {"text": "To determine whether these responses were common to other amphetamines of abuse, effects of methylenedioxymethamphetamine (MDMA) on the plasmalemmal DA transporter (DAT) and vesicular monoamine transporter-2 (VMAT-2) were assessed.", "entity1": "VMAT-2", "entity2": "MDMA", "span1": [209, 215], "span2": [123, 127]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"15280": {"label": 6, "data": {"text": "Synthesis and structure-activity relationships of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists.", "entity1": "CCR4", "entity2": "indazole arylsulfonamides", "span1": [115, 119], "span2": [50, 75]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, 6, -1, -1, -1, -1, -1, -1, -1]},
+	"7253": {"label": 4, "data": {"text": "PEA was a potent and full agonist at each species of TAAR1, whereas TYR was a full agonist for the rodent TAAR1s but was a partial agonist at h-rChTAAR1.", "entity1": "rodent TAAR1s", "entity2": "TYR", "span1": [99, 112], "span2": [68, 71]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14369": {"label": 3, "data": {"text": "Several effects of polyphenols are useful in this scenario, including a reduction in the activities of cytokines and modulation of cellular metabolism through histone deacetylase inhibitors, AMPK activators, calorie-restriction mimetics or epigenetic regulators.", "entity1": "cytokines", "entity2": "polyphenols", "span1": [103, 112], "span2": [19, 30]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14345": {"label": 3, "data": {"text": "The expression of the osteoblast markers runt-related transcription factor 2 (RUNX2) and periostin was decreased, while osteocalcin (OCN) was augmented in CCL3(-/-) and Met-RANTES-treated mice.", "entity1": "RUNX2", "entity2": "Met", "span1": [78, 83], "span2": [169, 172]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9243": {"label": 8, "data": {"text": "In cell culture experiments, it was found that triclosan inhibited IL-1 beta induced prostaglandin E2 production by human gingival fibroblasts in a concentration dependent manner, and at relatively low concentrations.", "entity1": "IL-1 beta", "entity2": "prostaglandin E2", "span1": [67, 76], "span2": [85, 101]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"14934": {"label": 3, "data": {"text": "Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease.", "entity1": "phosphodiesterase 5", "entity2": "quinoline", "span1": [72, 91], "span2": [13, 22]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14836": {"label": 1, "data": {"text": "This shift in conformational population at higher Mg(2+) ion concentrations and to lower enzyme activity may be due to longer residence time of the NADH in the ALDH1 pocket.", "entity1": "ALDH1", "entity2": "NADH", "span1": [160, 165], "span2": [148, 152]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13058": {"label": 3, "data": {"text": "Enhancement of radiosensitivity by topoisomerase II inhibitor, amrubicin and amrubicinol, in human lung adenocarcinoma A549 cells and kinetics of apoptosis and necrosis induction.", "entity1": "topoisomerase II", "entity2": "amrubicinol", "span1": [35, 51], "span2": [77, 88]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3947": {"label": 3, "data": {"text": "These observations suggest that uptake of phenformin into liver mitochondria is at least partly mediated by OCTN1 and functionally relevant to its inhibition potential of complex I respiration.", "entity1": "complex I", "entity2": "phenformin", "span1": [171, 180], "span2": [42, 52]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10212": {"label": 1, "data": {"text": "The increase in AMPK alpha2 activity was likely due to a change in muscle energy status because ATP and phosphocreatine concentrations were lower after metformin treatment.", "entity1": "AMPK alpha2", "entity2": "ATP", "span1": [16, 27], "span2": [96, 99]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2731": {"label": 2, "data": {"text": "Under isotonic conditions, N-ethylmaleimide (NEM) produced KCC activation and transient cell shrinkage.", "entity1": "KCC", "entity2": "N-ethylmaleimide", "span1": [59, 62], "span2": [27, 43]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"9539": {"label": 8, "data": {"text": "Increased Cat3-mediated cationic amino acid transport functionally compensates in Cat1 knockout cell lines.", "entity1": "Cat3", "entity2": "amino acid", "span1": [10, 14], "span2": [33, 43]}, "weak_labels": [0, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"6968": {"label": 1, "data": {"text": "As CRABPI was elevated far more than any other genes, we observed that the retinoids, all-trans retinoic acid and 9-cis retinoic acid, that bind CRABPI, promoted nitroblue tetrazolium-associated functional cell differentiation in p75NTR PC-3 cells, but not in neo control PC-3 cells.", "entity1": "p75NTR", "entity2": "all-trans retinoic acid", "span1": [230, 236], "span2": [86, 109]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"12169": {"label": 1, "data": {"text": "The average occupancy of bupropion on DAT was similar to the international findings at 20.84% in 9 depressed patients.", "entity1": "DAT", "entity2": "bupropion", "span1": [38, 41], "span2": [25, 34]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3819": {"label": 4, "data": {"text": "Binding of the agonist angiotensin II (AngII) and inverse agonist losartan in wild-type AT1R changed the accessibility of reporter cysteines, and the pattern was consistent with ligand-specific \"lid\" conformations of ECL2.", "entity1": "AT1R", "entity2": "losartan", "span1": [88, 92], "span2": [66, 74]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10241": {"label": 8, "data": {"text": "In attempting to clone the PAO involved in this back-conversion pathway, we encountered an oxidase that preferentially cleaves spermine in the absence of prior acetylation by SSAT.", "entity1": "SSAT", "entity2": "spermine", "span1": [175, 179], "span2": [127, 135]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1]},
+	"13744": {"label": 1, "data": {"text": "Inhibition of (+)-[(3)H]isradipine binding to Ca(v)1.2DHP(-/-) (predominantly Ca(v)1.3) and wild-type (predominantly Ca(v)1.2) brain membranes by unlabeled DHPs revealed a 3- to 4-fold selectivity of nitrendipine and nifedipine for the Ca(v)1.2 binding pocket, a finding further confirmed with heterologously expressed channels.", "entity1": "Ca(v)1.3", "entity2": "(+)-[(3)H]isradipine", "span1": [78, 86], "span2": [14, 34]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1012": {"label": 2, "data": {"text": "Moreover, IGFBP-rP2 noticeably increased in response to TGF-beta1 and all-trans retinoic acid (atRA) in HPEC and PC-3 cells, and it decreased in response to IGF-I in HPEC.", "entity1": "IGFBP-rP2", "entity2": "all-trans retinoic acid", "span1": [10, 19], "span2": [70, 93]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"14252": {"label": 1, "data": {"text": "Other groups received either an infusion of the selective NMDA receptor antagonist (AP7; 10 nmol; intra-mPFC) or vehicle, 10 min prior to PILO preceding LFS600, or prior to a supra-threshold LTD protocol (900 pulses, 1 Hz; LFS900).", "entity1": "NMDA receptor", "entity2": "PILO", "span1": [58, 71], "span2": [138, 142]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11890": {"label": 8, "data": {"text": "Ferredoxin 1 (FDX1; adrenodoxin) is an iron-sulfur protein that is involved in various metabolic processes, including steroid hormone synthesis in mammalian tissues.", "entity1": "Ferredoxin 1", "entity2": "steroid hormone", "span1": [0, 12], "span2": [118, 133]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4798": {"label": 1, "data": {"text": "The neurotrophic factors pleiotrophin (PTN) and midkine (MK) have been shown to modulate amphetamine-induced neurotoxicity.", "entity1": "pleiotrophin", "entity2": "amphetamine", "span1": [25, 37], "span2": [89, 100]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8997": {"label": 3, "data": {"text": "Enprofylline, a weak adenosine antagonist but potent inhibitor of cyclic AMP phosphodiesterase, did not alter ethanol's motor incoordination, further supporting involvement of brain adenosine receptor mechanism(s) in ethanol-adenosine interactions.", "entity1": "cyclic AMP phosphodiesterase", "entity2": "Enprofylline", "span1": [66, 94], "span2": [0, 12]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"11904": {"label": 3, "data": {"text": "Western blotting demonstrated that DMBT effectively suppressed the expression of VEGF, p-VEGFR-2, p-EGFR, and p-Akt.", "entity1": "p-Akt", "entity2": "DMBT", "span1": [110, 115], "span2": [35, 39]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8234": {"label": 4, "data": {"text": "ICA is a mixed agonist of mutant EAG and EAG/ERG chimera channels that inactivate by a combination of slow and fast mechanisms.", "entity1": "EAG", "entity2": "ICA", "span1": [33, 36], "span2": [0, 3]}, "weak_labels": [-1, -1, 0, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7155": {"label": 9, "data": {"text": "However, the expression of AT1R was not suppressed by other AT1R antagonists such as candesartan or olmesartan.", "entity1": "AT1R", "entity2": "candesartan", "span1": [27, 31], "span2": [85, 96]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"4593": {"label": 3, "data": {"text": "This work resulted in the discovery of the 5-morpholino-7H-thieno[3,2-b]pyran-7-one system as the foundation of a new compound class of potential PI3K inhibitors having improved potency toward PI3K.", "entity1": "PI3K", "entity2": "5-morpholino-7H-thieno[3,2-b]pyran-7-one", "span1": [146, 150], "span2": [43, 83]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6263": {"label": 4, "data": {"text": "beta 2-Adrenoceptor cardiovascular function was assessed by the increase in heart rate and reduction of diastolic blood pressure induced by an incremental intravenous infusion of the unselective beta-adrenoceptor agonist isoprenaline; beta 1-adrenoceptor cardiovascular function was assessed by exercise-induced tachycardia.", "entity1": "beta-adrenoceptor", "entity2": "isoprenaline", "span1": [195, 212], "span2": [221, 233]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, 3, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6120": {"label": 3, "data": {"text": "When MAO-B was also inhibited, 10 nmol/l amezinium caused 84% inhibition of the deamination of noradrenaline by MAO-A in the lungs.", "entity1": "MAO-A", "entity2": "amezinium", "span1": [112, 117], "span2": [41, 50]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1077": {"label": 1, "data": {"text": "Differential inhibition of [3H]-oxotremorine-M and [3H]-quinuclinidyl benzilate binding to muscarinic receptors in rat brain membranes with acetylcholinesterase inhibitors.", "entity1": "muscarinic receptors", "entity2": "[3H]-quinuclinidyl benzilate", "span1": [91, 111], "span2": [51, 79]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4760": {"label": 3, "data": {"text": "Previously, we have found that BRN-103, a nicotinamide derivative, inhibits vascular endothelial growth factor (VEGF)-mediated angiogenesis signaling in human endothelial cells.", "entity1": "VEGF", "entity2": "BRN-103", "span1": [112, 116], "span2": [31, 38]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13081": {"label": 1, "data": {"text": "This dual mode of action of sulfonylureas and glinides may open new perspectives for the molecular pharmacology of antidiabetic drugs, because it provides evidence that drugs can be designed that target both the sulfonylurea receptor and PPARgamma.", "entity1": "sulfonylurea receptor", "entity2": "sulfonylureas", "span1": [212, 233], "span2": [28, 41]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11314": {"label": 3, "data": {"text": "Ten IU/mL urokinase was also incubated with pooled plasma of stroke patients, that was previously oxidized with the singlet oxygen (1O2) donor chloramine T (CT), to destroy plasmatic PAI-1 and alpha2-antiplasmin.", "entity1": "plasmatic PAI-1", "entity2": "chloramine T", "span1": [173, 188], "span2": [143, 155]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"16040": {"label": 2, "data": {"text": "The caspase-3 immunopositivity was increased in degenerating neurons of the Cd group.", "entity1": "caspase-3", "entity2": "Cd", "span1": [4, 13], "span2": [76, 78]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10632": {"label": 3, "data": {"text": "Orlistat is an inhibitor of pancreatic lipase which is able to block the absorption of 30% of ingested fat.", "entity1": "pancreatic lipase", "entity2": "Orlistat", "span1": [28, 45], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6225": {"label": 1, "data": {"text": "Eletriptan, like sumatriptan, zolmitriptan, naratriptan and rizatriptan had highest affinity for the human 5-HT1B, 5-HT1D and putative 5-ht1f receptor.", "entity1": "5-HT1D", "entity2": "rizatriptan", "span1": [115, 121], "span2": [60, 71]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11729": {"label": 0, "data": {"text": "The 3D-structure of HmTx consists of three conserved alpha-helices: h1 (Lys24-His34), h2 (Cys59-Asp71), and h3 (Ala80-Phe89).", "entity1": "HmTx", "entity2": "Lys", "span1": [20, 24], "span2": [72, 75]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5123": {"label": 3, "data": {"text": "In addition, 5HHMF blocked LPS-induced phosphorylation of I\u03baB, resulting in suppression of the nuclear translocation of nuclear factor-\u03baB (NF-\u03baB) subunits, namely p65 and p50, which are important molecules involved in the regulation of iNOS expression.", "entity1": "p50", "entity2": "5HHMF", "span1": [171, 174], "span2": [13, 18]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8556": {"label": 3, "data": {"text": "tert-Butylcarbamate-Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells.", "entity1": "Histone Deacetylase", "entity2": "tert-Butylcarbamate", "span1": [31, 50], "span2": [0, 19]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9875": {"label": 3, "data": {"text": "Troglitazone reduces plasminogen activator inhibitor-1 expression and secretion in cultured human adipocytes.", "entity1": "plasminogen activator inhibitor-1", "entity2": "Troglitazone", "span1": [21, 54], "span2": [0, 12]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"16034": {"label": 3, "data": {"text": "In line with this observation, incubation of striatal slices with okadaic acid and calyculin A, two inhibitors of PP-1, increased Ser240/244 phosphorylation.", "entity1": "PP-1", "entity2": "okadaic acid", "span1": [114, 118], "span2": [66, 78]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8911": {"label": 5, "data": {"text": "Sedation and histamine H1-receptor antagonism: studies in man with the enantiomers of chlorpheniramine and dimethindene.", "entity1": "histamine H1-receptor", "entity2": "dimethindene", "span1": [13, 34], "span2": [107, 119]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10634": {"label": 3, "data": {"text": "Troglitazone, bosentan and glibenclamide inhibit the bile salt export pump (Bsep) which transports taurocholate into bile.", "entity1": "bile salt export pump", "entity2": "Troglitazone", "span1": [53, 74], "span2": [0, 12]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"5133": {"label": 3, "data": {"text": "Pyrrolidine dithiocarbamate (PDTC), a specific NF-\u03baB inhibitor, along with 20S proteasome inhibitor (PSI) significantly inhibited LPS-induced iNOS expression, which indirectly suggested that 5HHMF downregulated iNOS expression by suppressing NF-\u03baB activity.", "entity1": "NF-\u03baB", "entity2": "PDTC", "span1": [47, 52], "span2": [29, 33]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, 3, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14649": {"label": 8, "data": {"text": "Wild-type enzymes and variants of CDA (Lys27Gln and Ala70Thr) and DCK (Ile24Val, Ala119Gly, and Pro122Ser) were expressed in and purified from Escherichia coli, and enzyme kinetic parameters were estimated for cytarabine (Ara-C), dFdC, and its metabolite 2',2'-difluorodeoxyuridine (dFdU) as substrates.", "entity1": "Ile24Val", "entity2": "cytarabine", "span1": [71, 79], "span2": [210, 220]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"12217": {"label": 1, "data": {"text": "This mechanism involves the calcium-dependent tyrosine kinase Pyk2, the non-receptor tyrosine kinase c-Src and the focal adhesion protein/steroid receptor co-factor, Hic-5.", "entity1": "c-Src", "entity2": "calcium", "span1": [101, 106], "span2": [28, 35]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13949": {"label": 4, "data": {"text": "salmeterol and formoterol, for the beta(2)-adrenoceptor over the beta(1) or beta(3)), while others (e.g.", "entity1": "beta(1)", "entity2": "salmeterol", "span1": [65, 72], "span2": [0, 10]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3754": {"label": 3, "data": {"text": "The pretreatment with 20\u00a0mg\u2009L(-1) La(III) could alleviate the effects of UV-B radiation on the activities of nitrate reductase, glutamine synthetase, glutamate synthase, and glutamate dehydrogenase, promoting amino acid conversion and protein synthesis in soybean seedlings.", "entity1": "glutamate dehydrogenase", "entity2": "La(III)", "span1": [174, 197], "span2": [34, 41]}, "weak_labels": [0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1]},
+	"11678": {"label": 0, "data": {"text": "Antibodies to either the C- or N- terminus of VMAT-1 detected two proteins (73 and 55 kD) in transfected COS-1 cells.", "entity1": "VMAT-1", "entity2": "C", "span1": [46, 52], "span2": [25, 26]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"645": {"label": 3, "data": {"text": "Sumatriptan and LY 344864 decreased the number of capsaicin-induced c-fos-like immunoreactive cells within trigeminal nucleus caudalis (ID50 = 0.04 and 0.6 mg kg(-1)).", "entity1": "c-fos", "entity2": "LY 344864", "span1": [68, 73], "span2": [16, 25]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5657": {"label": 2, "data": {"text": "We reported that superfusion of hERG-expressing HEK293 (hERG-HEK) cells with matrine (1, 10 \u03bcM) increased the hERG current by promoting hERG channel activation.", "entity1": "hERG", "entity2": "matrine", "span1": [136, 140], "span2": [77, 84]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11584": {"label": 2, "data": {"text": "As add-on therapy in patients with suboptimal glycaemic control despite oral antihyperglycaemic treatment, sitagliptin improved HbA(1c) to a significantly greater extent than placebo when added to metformin or pioglitazone and was noninferior to glipizide when added to metformin.", "entity1": "HbA(1c)", "entity2": "pioglitazone", "span1": [128, 135], "span2": [210, 222]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12615": {"label": 1, "data": {"text": "The nuclear gene transcription factors RAR beta and RAR gamma mediate the retinoid activity of adapalene.", "entity1": "RAR beta", "entity2": "adapalene", "span1": [39, 47], "span2": [95, 104]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3776": {"label": 1, "data": {"text": "Both 5'-AMN and 5'-MABN had high affinity for \u03ba-receptors (K (i) 1.36 \u00b1 0.98 and 0.27 \u00b1 0.08, respectively) and were revealed as potent \u03ba-antagonists (pA(2) 7.43 and 8.18, respectively) and \u03bc-receptor antagonists (pA(2) 7.62 and 7.85, respectively) in the ileum.", "entity1": "\u03ba-receptors", "entity2": "5'-AMN", "span1": [46, 57], "span2": [5, 11]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"16014": {"label": 5, "data": {"text": "The involvement of the various DA receptor subtypes in the motor effects of N/OFQ and NOP receptor antagonists was evaluated pharmacologically, using D1/D5 (SCH23390), D2/D3 (raclopride, amisulpride) and D3 (S33084) receptor antagonists, and by using D2 receptor knockout mice.", "entity1": "D5", "entity2": "SCH23390", "span1": [153, 155], "span2": [157, 165]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12163": {"label": 1, "data": {"text": "CONCLUSIONS: The most interesting findings were the high mRNA expression of P2Y12 receptors in lymphocytes potentially explaining the anti-inflammatory effects of clopidogrel, P2Y13 receptors in monocytes and a previously unrecognised expression of P2X4 in lymphocytes and monocytes.", "entity1": "P2Y12", "entity2": "clopidogrel", "span1": [76, 81], "span2": [163, 174]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2847": {"label": 0, "data": {"text": "The cAspAT TZD-responsive site was restricted to a single AGGACA hexanucleotide located at -381 to -376 bp whose mutation impaired the specific RORalpha binding.", "entity1": "cAspAT", "entity2": "hexanucleotide", "span1": [4, 10], "span2": [65, 79]}, "weak_labels": [-1, -1, 0, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13176": {"label": 2, "data": {"text": "Progestin induction of the cyclin D1 gene, which lacks a progesterone response element, was dependent on PR activation of the Src/MAPK pathway, whereas induction of the Sgk (serum and glucocorticoid regulated kinase) gene that contains a functional progesterone response element was unaffected by mutations that interfere with PR activation of Src.", "entity1": "PR", "entity2": "Progestin", "span1": [105, 107], "span2": [0, 9]}, "weak_labels": [-1, -1, 0, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9388": {"label": 1, "data": {"text": "Interactions of 2,3-benzodiazepines and cyclothiazide at AMPA receptors: patch clamp recordings in cultured neurones and area CA1 in hippocampal slices.", "entity1": "AMPA receptors", "entity2": "2,3-benzodiazepines", "span1": [57, 71], "span2": [16, 35]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6353": {"label": 5, "data": {"text": "Among the current AT1 receptor antagonists, the rank order of the relative binding affinities (highest affinity = 1) is: candesartan 1, telmisartan 10, E3174 (the active metabolite of losartan) 10, tasosartan 20, losartan 50, eprosartan 100 and the prodrug candesartan cilexetil 280.", "entity1": "AT1", "entity2": "candesartan cilexetil", "span1": [18, 21], "span2": [257, 278]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12474": {"label": 9, "data": {"text": "UGT2B10 was inactive in the glucuronidation of desipramine, nortriptyline, carbamazepine and afloqualone.", "entity1": "UGT2B10", "entity2": "carbamazepine", "span1": [0, 7], "span2": [75, 88]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"140": {"label": 3, "data": {"text": "Similarly, felodipine and the p-chloro analogue inhibited myosin light chain kinase activity whether the isolated 20 kD light chain (IC50 = 12.6 microM) or intact myosin (IC50 = 11.0 microM) was used as substrate.", "entity1": "myosin light chain kinase", "entity2": "p-chloro", "span1": [58, 83], "span2": [30, 38]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"15356": {"label": 8, "data": {"text": "Additionally, there was a significant difference in plasma concentrations of (R)-5-hydroxyomeprazole among CYP2C19 genotype groups, whereas no significant differences were observed in that of (S)-5-hydroxyomeprazole.", "entity1": "CYP2C19", "entity2": "(S)-5-hydroxyomeprazole", "span1": [107, 114], "span2": [192, 215]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"5976": {"label": 3, "data": {"text": "Mimosine, a well-known competitive inhibitor of tyrosinase, competitively inhibited the new reaction also.", "entity1": "tyrosinase", "entity2": "Mimosine", "span1": [48, 58], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12959": {"label": 1, "data": {"text": "Agents that specifically target BRAF, such as sorafenib, as well as new molecules that function both upstream and downstream of BRAF, are being actively investigated.", "entity1": "BRAF", "entity2": "sorafenib", "span1": [32, 36], "span2": [46, 55]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10703": {"label": 4, "data": {"text": "Denufosol tetrasodium (INS37217) is a selective P2Y(2) agonist that stimulates ciliary beat frequency and Cl(-) secretion in normal and cystic fibrosis (CF) airway epithelia, and is being investigated as an inhaled treatment for CF.", "entity1": "P2Y(2)", "entity2": "INS37217", "span1": [48, 54], "span2": [23, 31]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6588": {"label": 8, "data": {"text": "It is caused by a deficiency of propionyl-CoA carboxylase (PCC, EC 6.4.1.3), a biotin-dependent enzyme that catalyzes the carboxylation of propionyl-CoA to D-methylmalonyl-CoA.", "entity1": "EC 6.4.1.3", "entity2": "D-methylmalonyl-CoA", "span1": [64, 74], "span2": [156, 175]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"4241": {"label": 8, "data": {"text": "These findings, derived from a variety of analytical and functional approaches, provide evidence for a novel nongenomic signaling mechanism for androgen action in the microvasculature: TES-stimulated vasodilation mediated primarily by peroxynitrite formed from xanthine oxidase-generated superoxide and NO.", "entity1": "xanthine oxidase", "entity2": "NO", "span1": [261, 277], "span2": [303, 305]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3179": {"label": 2, "data": {"text": "We investigated the involvement of the farnesoid X receptor (FXR), a nuclear receptor for bile acids, in the chenodeoxycholic acid (CDCA)-induced expression of Cdx2 and MUC2 in normal rat gastric epithelial cells (RGM-1 cells).", "entity1": "Cdx2", "entity2": "CDCA", "span1": [160, 164], "span2": [132, 136]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4068": {"label": 2, "data": {"text": "Cortisol and IFNT stimulated endometrial HSD11B1 expression and activity, increased endometrial PTGS2 activity and the amount of PG in the uterine lumen, and up-regulated many conceptus elongation-related genes in the endometrium.", "entity1": "PTGS2", "entity2": "Cortisol", "span1": [96, 101], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3476": {"label": 5, "data": {"text": "The anti-hyperthermic effect of Lu AF21934 (5 mg/kg) in the SIH test was inhibited by the benzodiazepine receptor antagonist flumazenil (10 mg/kg) and was not serotonin-dependent, as it persisted in serotonin-deficient mice and upon blockade of either 5-HT(1A) receptors by WAY100635, or 5-HT(2A/2C) receptors by ritanserin.", "entity1": "benzodiazepine receptor", "entity2": "flumazenil", "span1": [90, 113], "span2": [125, 135]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"9085": {"label": 3, "data": {"text": "13cisRA and ROAc, but not 4HPR, caused a dose-dependent reduction in plasma osteocalcin, an effect that correlated with retinoid-induced bone effects.", "entity1": "osteocalcin", "entity2": "4HPR", "span1": [76, 87], "span2": [26, 30]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"12374": {"label": 8, "data": {"text": "This shows that CPT2 and CACT are crucial for mitochondrial acylcarnitine formation and export to the extracellular fluids in mFAOD.-Violante, S., IJlst, L., te Brinke, H., Tavares de Almeida, I., Wanders, R. J.", "entity1": "CPT2", "entity2": "acylcarnitine", "span1": [16, 20], "span2": [60, 73]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7982": {"label": 1, "data": {"text": "Furthermore, U0126 (an ERK1/2 inhibitor) significantly enhanced the ISO-induced the Bax/Bcl-2 ratio, the release of cytochrome c to the cytosol fraction, and the levels of cleaved caspase-3.", "entity1": "caspase-3", "entity2": "U0126", "span1": [180, 189], "span2": [13, 18]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11520": {"label": 1, "data": {"text": "Dexamethasone probes glucocorticoid receptor (GR) function, while prednisolone probes both GR and mineralocorticoid receptor (MR) function.", "entity1": "GR", "entity2": "Dexamethasone", "span1": [46, 48], "span2": [0, 13]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7631": {"label": 5, "data": {"text": "All neurotrophic effects were blocked by the unselective D2/D3 receptor antagonist sulpiride (5 microm) and by the selective D3 receptor antagonist SB-277011-A at a low dose (50 nm).", "entity1": "D3 receptor", "entity2": "SB-277011-A", "span1": [125, 136], "span2": [148, 159]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"297": {"label": 3, "data": {"text": "In catalytic properties, mouse CA V is closest to CA I; however, in inhibition by acetazolamide, ethoxzolamide, and cyanate, CA V is very similar to CA II.", "entity1": "CA V", "entity2": "cyanate", "span1": [125, 129], "span2": [116, 123]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5105": {"label": 2, "data": {"text": "5-Hydroxy-3,6,7,8,3'4'-hexamethoxyflavone inhibits nitric oxide production in lipopolysaccharide-stimulated BV2 microglia via NF-\u03baB suppression and Nrf-2-dependent heme oxygenase-1 induction.", "entity1": "Nrf-2", "entity2": "5-Hydroxy-3,6,7,8,3'4'-hexamethoxyflavone", "span1": [148, 153], "span2": [0, 41]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"11654": {"label": 1, "data": {"text": "The effects of CDCA and GW4064 on expression of Cdx2 and MUC2 were abolished by guggulsterone.", "entity1": "MUC2", "entity2": "GW4064", "span1": [57, 61], "span2": [24, 30]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1854": {"label": 3, "data": {"text": "Some of these derivatives showed good inhibitory potency against two human CA isozymes involved in important physiological processes, CA I, and CA II, of the same order of magnitude as the clinically used drugs acetazolamide and methazolamide.", "entity1": "human CA", "entity2": "acetazolamide", "span1": [69, 77], "span2": [211, 224]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5619": {"label": 8, "data": {"text": "We found that although inactivation facilitated cisapride block of the HERG K+ current, it was not coupled with cisapride block of HERG when the Cs+ current was recorded.", "entity1": "HERG", "entity2": "Cs+", "span1": [71, 75], "span2": [145, 148]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"15056": {"label": 8, "data": {"text": "Cellular zinc is controlled by zinc-chelating proteins and by zinc transporters.", "entity1": "zinc transporters", "entity2": "zinc", "span1": [62, 79], "span2": [9, 13]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"3716": {"label": 3, "data": {"text": "Furthermore, N-BPs decreased the levels of phosphorylated extracellular signal-regulated kinase (ERK) and mTOR via suppression of Ras prenylation and enhanced Bim expression.", "entity1": "phosphorylated extracellular signal-regulated kinase", "entity2": "N", "span1": [43, 95], "span2": [13, 14]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9938": {"label": 3, "data": {"text": "RESULTS: NF-kappaB/Rel activity induced by tumor necrosis factor alpha, 12-O-tetradecanoylphorbol-13-acetate, or overexpression of NF-kappaB-inducing kinase, IKK-alpha, IKK-beta, or constitutively active IKK-alpha and IKK-beta mutants was inhibited dose dependently by sulfasalazine.", "entity1": "Rel", "entity2": "sulfasalazine", "span1": [19, 22], "span2": [269, 282]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3891": {"label": 3, "data": {"text": "Importantly, the carboxylic acid of JY-3-094 improves the physicochemical properties of the lead compound, which will facilitate the incorporation of additional hydrophobicity that might enhance Myc inhibitory activity further still.", "entity1": "Myc", "entity2": "JY-3-094", "span1": [195, 198], "span2": [36, 44]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8021": {"label": 8, "data": {"text": "Dual function inhibitors targeting phospholipase A(2) (PLA(2)) and leukotriene A(4) hydrolase (LTA(4)H) may balance the arachidonic acid (AA) metabolic network and be used as new anti-inflammatory drugs.", "entity1": "PLA(2)", "entity2": "arachidonic acid", "span1": [55, 61], "span2": [120, 136]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7657": {"label": 3, "data": {"text": "MMP-2 and MMP-9 expressions and activities in right ventricles increased significantly in monocrotaline-injected rats and captopril inhibited them.", "entity1": "MMP-9", "entity2": "captopril", "span1": [10, 15], "span2": [122, 131]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15893": {"label": 8, "data": {"text": "This includes nonribosomal peptide synthetases (NRPS) and polyketide synthases (PKS) required for the formation of the benzopyranopyrrole core unit, as well as a suite of tailoring enzymes (e.g., four halogenases, an O-methyltransferase, and an N-glycosyltransferase) necessary for further modifications of the core structure.", "entity1": "nonribosomal peptide synthetases", "entity2": "benzopyranopyrrole", "span1": [14, 46], "span2": [119, 137]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3484": {"label": 2, "data": {"text": "Swertiamarin treatment had no significant effect on adipogenesis, or the mRNA expression of PPAR-\u03b3 and GLUT-4; however, there was a significant increase in the mRNA expression of adiponectin.", "entity1": "adiponectin", "entity2": "Swertiamarin", "span1": [179, 190], "span2": [0, 12]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1636": {"label": 3, "data": {"text": "However, when naloxone was administered concurrently with ethanol treatment, it antagonized the down-regulation of p-CREB protein in the nucleus accumbens (142 %) of rats exposed to ethanol.", "entity1": "p-CREB", "entity2": "ethanol", "span1": [115, 121], "span2": [58, 65]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11659": {"label": 1, "data": {"text": "These results led us to consider that TAS-102 may also be effective for esophageal and uterine squamous cell carcinomas, as well as for gastrointestinal adenocarcinomas, even in fluoropyrimidine-resistant cases with high TS expression.", "entity1": "TS", "entity2": "TAS-102", "span1": [221, 223], "span2": [38, 45]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9722": {"label": 3, "data": {"text": "This study confirms the feasibility of using continuous measurement of AChE activity in CSF over prolonged periods, that rivastigmine markedly inhibits CSF AChE after a single oral dose of 3 mg, and that the inhibition of central AChE is substantially greater than that of peripheral AChE or BuChE.", "entity1": "AChE", "entity2": "rivastigmine", "span1": [284, 288], "span2": [121, 133]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6436": {"label": 3, "data": {"text": "RESULT(S): Buserelin acetate, a GnRH agonist (0.1-10 ng/mL), had no significant effect on MCP-1 expression, whereas danazol (10(-7)-10(-5) M), a testosterone analog, and dexamethasone, an anti-inflammatory glucocorticoid hormone (10(-12)-10(-6)M), showed a direct and a dose-dependent inhibitory effect on MCP-1 expression.", "entity1": "MCP-1", "entity2": "testosterone", "span1": [306, 311], "span2": [145, 157]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12183": {"label": 1, "data": {"text": "The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity.", "entity1": "renin", "entity2": "catecholamine", "span1": [82, 87], "span2": [50, 63]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4372": {"label": 2, "data": {"text": "We investigated the effects of the dose of and the number of times an inducer was administered and the duration of induction of hepatic and intestinal cytochrome P450 3A (CYP3A) in rats using dexamethasone 21-phosphate (DEX-P) and midazolam (MDZ) as an inducer and a substrate to CYP3A, respectively.", "entity1": "CYP3A", "entity2": "DEX-P", "span1": [280, 285], "span2": [220, 225]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"10922": {"label": 3, "data": {"text": "The gastric mucin secretory responses to isoproterenol, furthermore, were inhibited by PP2, a selective inhibitor of tyrosine kinase Src responsible for ligand-independent EGFR autophosphorylation, but not by ERK inhibitor, PD98059.", "entity1": "Src", "entity2": "PP2", "span1": [133, 136], "span2": [87, 90]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"9236": {"label": 3, "data": {"text": "Triclosan inhibited both cyclooxygenase 1 and cyclo-oxygenase 2 with IC-50 values of 43 microM and 227 microM, respectively.", "entity1": "cyclooxygenase 1", "entity2": "Triclosan", "span1": [25, 41], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2241": {"label": 3, "data": {"text": "Dasatinib (BMS-354825) is a novel orally bioavailable SRC/ABL inhibitor that has activity against multiple imatinib-resistant BCR-ABL isoforms in vitro that is presently showing considerable promise in early-phase clinical trials of chronic myeloid leukemia (CML).", "entity1": "ABL", "entity2": "Dasatinib", "span1": [58, 61], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2585": {"label": 8, "data": {"text": "Methionine synthase reductase (MTRR) is an enzyme involved in the conversion of Hcy to methionine.", "entity1": "Methionine synthase reductase", "entity2": "methionine", "span1": [0, 29], "span2": [87, 97]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1]},
+	"13811": {"label": 3, "data": {"text": "Others kinase inhibitors used recently in cancer therapy include Dasatinib (BMS-354825) specific for ABL non-receptor cytoplasmic kinase, Gefitinib (Iressa), Erlotinib (OSI-774, Tarceva) and Sunitinib (SU 11248, Sutent) specific for VEGF receptor kinase, AMN107 (Nilotinib) and INNO-406 (NS-187) specific for c-KIT kinase.", "entity1": "kinase", "entity2": "Iressa", "span1": [247, 253], "span2": [149, 155]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"837": {"label": 3, "data": {"text": "Felbamate produced a rapid, concentration-dependent block of currents evoked by 50 microM NMDA and 10 microM glycine in human embryonic kidney 293 cells expressing the rat NR1a subunit, and either the NR2A, NR2B or NR2C subunits; the IC50 values for block were 2.6, 0.52 and 2.4 mM, respectively (holding potential, - 60 mV).", "entity1": "rat NR1a", "entity2": "Felbamate", "span1": [168, 176], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"14709": {"label": 3, "data": {"text": "Inhibition of Th1/Th17 responses via suppression of STAT1 and STAT3 activation contributes to the amelioration of murine experimental colitis by a natural flavonoid glucoside icariin.", "entity1": "STAT3", "entity2": "flavonoid", "span1": [62, 67], "span2": [155, 164]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5284": {"label": 2, "data": {"text": "In concert with these results, we highlighted that the secretion of pro-inflammatory cytokine and NF-\u03baB activation induced by TCDD can be mediated by elevation of [Ca(2+)]i in HAPI microglial cells.", "entity1": "NF-\u03baB", "entity2": "TCDD", "span1": [98, 103], "span2": [126, 130]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15943": {"label": 1, "data": {"text": "We also recorded a significant correlation between M value increase and the decrease of vaspin, visfatin, and omentin-1 obtained with vildagliptin+metformin.", "entity1": "vaspin", "entity2": "metformin", "span1": [88, 94], "span2": [147, 156]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6198": {"label": 5, "data": {"text": "administration of the non-selective muscarinic receptor antagonist atropine (ID50 = 1.45 microg), the muscarinic M1 receptor antagonist pirenzepine (ID50 = 4.33 microg), the muscarinic M2 receptor antagonist methoctramine (ID50 = 1.39 microg) and the muscarinic M3 receptor antagonist para-fluoro-hexahydro-sila-difenidol (ID50 = 31.19 microg).", "entity1": "muscarinic receptor", "entity2": "atropine", "span1": [36, 55], "span2": [67, 75]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9907": {"label": 2, "data": {"text": "Treatment of lactating mice with a single injection of bezafibrate, an activator of the peroxisome proliferator-activated receptor (PPAR), raises UCP-3 mRNA in skeletal muscle to levels similar to those in virgin mice.", "entity1": "peroxisome proliferator-activated receptor", "entity2": "bezafibrate", "span1": [88, 130], "span2": [55, 66]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"620": {"label": 3, "data": {"text": "Taken together, these data demonstrated that PLA2 inhibitors BPB and AACOCF3 are robust inhibitors of IL-2 expression at both the mRNA and protein levels in murine splenocytes.", "entity1": "IL-2", "entity2": "AACOCF3", "span1": [102, 106], "span2": [69, 76]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2623": {"label": 8, "data": {"text": "Adenine phosphoribosyltransferase plays a role in purine salvage by catalyzing the direct conversion of adenine to adenosine monophosphate.", "entity1": "Adenine phosphoribosyltransferase", "entity2": "adenosine monophosphate", "span1": [0, 33], "span2": [115, 138]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, 8, -1]},
+	"2415": {"label": 8, "data": {"text": "Reduced synthesis of nitric oxide (NO) contributes to the endothelial dysfunction and may be related to limited availability of L-arginine, the common substrate of constitutive nitric-oxide synthase (NOS) and cytosolic arginase I and mitochondrial arginase II.", "entity1": "constitutive nitric-oxide synthase", "entity2": "nitric oxide", "span1": [164, 198], "span2": [21, 33]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"13350": {"label": 1, "data": {"text": "In addition, BALB/c and C57BL/6 females were treated with progesterone or MPA for 1 or 2 months, and mammary glands were excised for histologic studies and for immunohistochemical and Western blot evaluation of ER and PR.", "entity1": "ER", "entity2": "MPA", "span1": [211, 213], "span2": [74, 77]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3543": {"label": 2, "data": {"text": "These results suggest that LTD4 increases A\u03b2 peptide burden via activation of CysLT(1)R, which further affects APP levels and activity of \u03b2- and \u03b3-secretases via the NF-\u03baB pathway.", "entity1": "CysLT(1)R", "entity2": "LTD4", "span1": [78, 87], "span2": [27, 31]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"662": {"label": 3, "data": {"text": "The effects of meloxicam were compared with those of diclofenac, a nonselective COX inhibitor.", "entity1": "COX", "entity2": "diclofenac", "span1": [80, 83], "span2": [53, 63]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6591": {"label": 1, "data": {"text": "These results indicate that quetiapine, iloperidone and melperone preferentially increase DA release in the mPFC, compared to the NAC via a 5-HT(1A)-related mechanism.", "entity1": "5-HT(1A)", "entity2": "melperone", "span1": [140, 148], "span2": [56, 65]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14347": {"label": 3, "data": {"text": "The expression of the osteoblast markers runt-related transcription factor 2 (RUNX2) and periostin was decreased, while osteocalcin (OCN) was augmented in CCL3(-/-) and Met-RANTES-treated mice.", "entity1": "runt-related transcription factor 2", "entity2": "Met", "span1": [41, 76], "span2": [169, 172]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12360": {"label": 8, "data": {"text": "Regulation of multiple adenylyl cyclases (AC) provides unique inputs to mediate the synthesis of cAMP, a ubiquitous second messenger that controls many aspects of cellular function.", "entity1": "adenylyl cyclases", "entity2": "cAMP", "span1": [23, 40], "span2": [97, 101]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12413": {"label": 8, "data": {"text": "This methodology was subsequently used to assess the relative contribution of OATP1B1 uptake in human hepatocytes for olmesartan (42%-62%), valsartan (28%-81%), rosuvastatin (64%-72%), pitavastatin (84%-98%) and lopinavir (64%-89%).", "entity1": "OATP1B1", "entity2": "lopinavir", "span1": [78, 85], "span2": [212, 221]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"944": {"label": 3, "data": {"text": "In contrast, 2, 4-dioxo-5-acetamido-6-phenylhexanoic acid, which is a competitive inhibitor with respect to ascorbate, exhibits a low degree of stereospecificity in binding to the ascorbate sites of both PAM and dopamine-beta-hydroxylase.", "entity1": "dopamine-beta-hydroxylase", "entity2": "2, 4-dioxo-5-acetamido-6-phenylhexanoic acid", "span1": [212, 237], "span2": [13, 57]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11860": {"label": 1, "data": {"text": "We examined the effects of anthocyanidins (cyanidin, delphinidin, malvidin, peonidin, petunidin, pelargonidin) on the aryl hydrocarbon receptor (AhR)-CYP1A1 signaling pathway in human hepatocytes, hepatic HepG2 and intestinal LS174T cancer cells.", "entity1": "aryl hydrocarbon receptor", "entity2": "cyanidin", "span1": [118, 143], "span2": [43, 51]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12543": {"label": 1, "data": {"text": "Amine oxidase activities in brown adipose tissue of the rat: identification of semicarbazide-sensitive (clorgyline-resistant) activity at the fat cell membrane.", "entity1": "Amine oxidase", "entity2": "semicarbazide", "span1": [0, 13], "span2": [79, 92]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8679": {"label": 3, "data": {"text": "While imatinib was unable to block cisplatin-induced DNA damage and damage response, such as the upregulation of p53, imatinib inhibited the cisplatin-induced nuclear accumulation of c-Abl/TAp73 and the subsequent downregulation of TAp63 and upregulation of Bax, thereby abrogating oocyte cell death.", "entity1": "TAp73", "entity2": "imatinib", "span1": [189, 194], "span2": [118, 126]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, 2, 3, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6604": {"label": 1, "data": {"text": "In vitro autoradiography studies (rat brain slices) with (S,S)-[(11)C]-MeNER produced a regional distribution pattern that was consistent with the reported distribution of NET.", "entity1": "NET", "entity2": "(S,S)-[(11)C]-MeNER", "span1": [172, 175], "span2": [57, 76]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"6732": {"label": 3, "data": {"text": "Compounds of several other structural families, including the quinoxaline AG1296, the bis(1H-2-indolyl)-1-methanone D-65476, the indolinones SU5416 and SU11248, the indolocarbazoles PKC412 and CEP-701, and the piperazonyl quinazoline CT53518, are potent inhibitors of Flt3 kinase.", "entity1": "Flt3", "entity2": "indolocarbazoles", "span1": [268, 272], "span2": [165, 181]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14455": {"label": 2, "data": {"text": "We observed similar effects of Ag NPs on inflammatory mediator expression in vitro and in vivo with increase of interleukin-8 (IL-8)/macrophage inflammatory protein 2, IL-1RI, and tumor necrosis factor-\u03b1 expression in both models and increased IL-8 protein release in vitro.", "entity1": "IL-8", "entity2": "Ag", "span1": [244, 248], "span2": [31, 33]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10225": {"label": 3, "data": {"text": "CONCLUSIONS: These results collectively indicate that thalidomide prevents alcoholic liver injury through suppression of TNF-alpha production and abolishment of KC sensitization.", "entity1": "TNF-alpha", "entity2": "thalidomide", "span1": [121, 130], "span2": [54, 65]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"2949": {"label": 0, "data": {"text": "The results quantify the role of PDE5 catalytic-site residues for cGMP and inhibitors, indicate that Tyr-612, Gln-817, and Phe-820 are the most important cGMP or inhibitor contacts studied, and identify residues that contribute to selectivity among different classes of inhibitors.", "entity1": "PDE5", "entity2": "Phe", "span1": [33, 37], "span2": [123, 126]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15882": {"label": 2, "data": {"text": "Our study revealed that high glucose/Fe concentrations in MIN6 cells induced an increase of the Bcl2/Bax ratio, an indicator of increased cell apoptosis.", "entity1": "Bcl2", "entity2": "glucose", "span1": [96, 100], "span2": [29, 36]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"138": {"label": 3, "data": {"text": "Felodipine and the p-chloro analogue inhibited Ca2+/calmodulin-dependent caldesmon kinase with similar potencies (IC50 = 17.4 microM), whereas the oxidized and t-butyl analogues caused no inhibition.", "entity1": "caldesmon kinase", "entity2": "p-chloro", "span1": [73, 89], "span2": [19, 27]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14716": {"label": 3, "data": {"text": "Pharmacological inhibition of MTORC1 with rapamycin abrogated the insulin-induced phosphorylation of EIF4EBP1, RPS6KB1 and its downstream effector, RPS6.", "entity1": "MTORC1", "entity2": "rapamycin", "span1": [30, 36], "span2": [42, 51]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13345": {"label": 8, "data": {"text": "Lymphocytes possess the essential components of a cholinergic system, including acetylcholine (ACh); choline acetyltransferase (ChAT), its synthesizing enzyme; and both muscarinic and nicotinic ACh receptors (mAChRs and nAChRs, respectively).", "entity1": "ChAT", "entity2": "ACh", "span1": [128, 132], "span2": [95, 98]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3790": {"label": 3, "data": {"text": "These results indicate that phillyrin prevents lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activation, suggesting that phillyrin is a novel AMPK activator with a role in the prevention and treatment of obesity.", "entity1": "SREBP-1c", "entity2": "phillyrin", "span1": [111, 119], "span2": [28, 37]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9166": {"label": 7, "data": {"text": "Phenylbutazone (PB), a nonsteroidal anti-inflammatory drug, is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS).", "entity1": "PHS", "entity2": "PB", "span1": [151, 154], "span2": [16, 18]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, 7, -1, -1, -1, -1, -1, -1]},
+	"1324": {"label": 3, "data": {"text": "Bupropion, an efficacious antidepressant and smoking cessation agent, inhibits dopamine and norepinephrine transporters (DAT and NET, respectively).", "entity1": "NET", "entity2": "Bupropion", "span1": [129, 132], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"8259": {"label": 4, "data": {"text": "Commercially-available 5-HT2C agonists (CP 809101, Ro 60-0175, WAY 161503, mCPP, and 1-methylpsilocin), novel\u00a04-phenyl-2-N,N-dimethyl-aminotetralin (PAT)-type 5-HT2C agonists (with 5-HT2A/2B antagonist activity), and antagonists selective for 5-HT2A (M100907), 5-HT2C (SB-242084), and 5-HT2B/2C (SB-206553) receptors attenuated the DOI-elicited-HTR.", "entity1": "5-HT2C", "entity2": "WAY 161503", "span1": [23, 29], "span2": [63, 73]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, 5, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"7189": {"label": 3, "data": {"text": "CONCLUSION: Intake of high SFAs and MUFAs appears to increase expression of PBMC D6D and D5D genes, whilst high EFAs intake appears to decrease expression of PBMC D6D and D5D genes.", "entity1": "D5D", "entity2": "EFAs", "span1": [171, 174], "span2": [112, 116]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2980": {"label": 1, "data": {"text": "The results quantify the role of PDE5 catalytic-site residues for cGMP and inhibitors, indicate that Tyr-612, Gln-817, and Phe-820 are the most important cGMP or inhibitor contacts studied, and identify residues that contribute to selectivity among different classes of inhibitors.", "entity1": "PDE5", "entity2": "cGMP", "span1": [33, 37], "span2": [66, 70]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15206": {"label": 3, "data": {"text": "In HaCaT cells, buthanol and ethylacetate fractions of 80% methanol C. fragile extract (CFB or CFE) and a single compound, clerosterol (CLS) isolated from CFE attenuated UVB (60mJ/cm(2))-induced cytotoxicity and reduced expression of pro-inflammatory proteins including cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and tumor necrosis factor-\u03b1 (TNF- \u03b1).", "entity1": "COX-2", "entity2": "ethylacetate", "span1": [288, 293], "span2": [29, 41]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"733": {"label": 2, "data": {"text": "Human and rat renin and angiotensinogen genes were downregulated in dTGR and were increased by losartan and cilazapril treatments, whereas no changes in the expression of rat ACE and AT1A receptor genes were observed.", "entity1": "angiotensinogen", "entity2": "losartan", "span1": [24, 39], "span2": [95, 103]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9956": {"label": 3, "data": {"text": "This effect may due to induction of apoptosis through uncoupling of oxidative phosphorylation and down-regulation of Bcl-2, as has been demonstrated for some nonselective NSAIDs, for instance, flurbiprofen.", "entity1": "Bcl-2", "entity2": "flurbiprofen", "span1": [117, 122], "span2": [193, 205]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2395": {"label": 0, "data": {"text": "In striking contrast, deletion of the corresponding C-terminal domain of Escherichia coli LeuRS abolished aminoacylation of tRNALeu and also amino acid editing of mischarged tRNA molecules.", "entity1": "Escherichia coli LeuRS", "entity2": "C", "span1": [73, 95], "span2": [52, 53]}, "weak_labels": [0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14201": {"label": 1, "data": {"text": "Galantamine is a reversible, competitive acetylcholinesterase (AChE) inhibitor and allosteric potentiating ligand of nicotinic acetylcholine receptors (nAChR-APL) that shares many common structural elements with morphinan-based opioids.", "entity1": "nicotinic acetylcholine receptors", "entity2": "Galantamine", "span1": [117, 150], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1]},
+	"3052": {"label": 3, "data": {"text": "Plerixafor (AMD3100, Genzyme Corporation) is a bicyclam molecule that antagonizes the binding of the chemokine stromal cell-derived factor-1 (SDF-1) to its cognate receptor CXCR4.", "entity1": "SDF-1", "entity2": "Plerixafor", "span1": [142, 147], "span2": [0, 10]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15231": {"label": 3, "data": {"text": "In overexpressing cell lines, OATP1B1- and OATP1B3-mediated estradiol-17\u03b2-glucuronide uptake and OATP2B1-mediated estrone-3-sulfate uptake were inhibited by most of the silymarin flavonolignans investigated.", "entity1": "OATP1B1", "entity2": "flavonolignans", "span1": [30, 37], "span2": [179, 193]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10699": {"label": 8, "data": {"text": "Ex vivo, lumiracoxib inhibited COX-1-derived thromboxane B(2) (TxB(2)) generation with an ID(50) of 33 mg kg(-1), whereas COX-2-derived production of prostaglandin E(2) (PGE(2)) in the lipopolysaccharide-stimulated rat air pouch was inhibited with an ID(50) value of 0.24 mg kg(-1).", "entity1": "COX-2", "entity2": "PGE(2)", "span1": [122, 127], "span2": [170, 176]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"13446": {"label": 1, "data": {"text": "The inhibitory effects of GW9662 and T0070907 (PPARgamma antagonists), on COX-2 expression and on stimulation of COX-2 promoter activity by EPA and GLA suggest that PPARgamma is implicated in COX-2 induction.", "entity1": "COX-2 promoter", "entity2": "GLA", "span1": [113, 127], "span2": [148, 151]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, 3, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1560": {"label": 8, "data": {"text": "One of the enzymes responsible for the production of KA, kynurenine aminotransferase I (KATI), also catalyses the reversible transamination of glutamine to oxoglutaramic acid (GTK, EC 2.6.1.15).", "entity1": "kynurenine aminotransferase I", "entity2": "KA", "span1": [57, 86], "span2": [53, 55]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, 8, -1, 9]},
+	"10280": {"label": 2, "data": {"text": "Long-term administration of propargylamines to rats increased the activities of antioxidative enzymes superoxide dismutase (SOD) and catalase in the brain regions containing dopamine neurons.", "entity1": "catalase", "entity2": "propargylamines", "span1": [133, 141], "span2": [28, 43]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3945": {"label": 3, "data": {"text": "Phenformin causes lactic acidosis in clinical situations due to inhibition of mitochondrial respiratory chain complex I.", "entity1": "mitochondrial respiratory chain complex I", "entity2": "Phenformin", "span1": [78, 119], "span2": [0, 10]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15110": {"label": 1, "data": {"text": "Characterization of cytosolic glutathione peroxidase and phospholipid-hydroperoxide glutathione peroxidase genes in rainbow trout (Oncorhynchus mykiss) and their modulation by in vitro selenium exposure.", "entity1": "cytosolic glutathione peroxidase", "entity2": "selenium", "span1": [20, 52], "span2": [185, 193]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13298": {"label": 3, "data": {"text": "We investigated the efficacy of sorafenib at inhibiting mutants of the receptor tyrosine kinases PDGFRbeta, KIT, and FLT3, which are implicated in the pathogenesis of myeloid malignancies.", "entity1": "receptor tyrosine kinases", "entity2": "sorafenib", "span1": [71, 96], "span2": [32, 41]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1764": {"label": 1, "data": {"text": "This study demonstrates enhanced cardiostimulation by CGP 12177A (in the presence of propranolol) in rat ventricular myocytes overexpressing beta(1)-adrenoceptors, mediated by a Gs/cAMP signalling pathway.", "entity1": "beta(1)-adrenoceptors", "entity2": "propranolol", "span1": [141, 162], "span2": [85, 96]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14491": {"label": 8, "data": {"text": "Human liver microsomes of the wild-type CYP2D6 metabolized 5-methoxytryptamine to serotonin more effectively than did the defective CYP2D6*4*4 ones.", "entity1": "CYP2D6", "entity2": "5-methoxytryptamine", "span1": [132, 138], "span2": [59, 78]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4847": {"label": 2, "data": {"text": "The ROS scavenger N-acetyl l-cysteine and the mitochondrial antioxidant Mito-TEMPO rescued the inhibitory effect of cucurbitacin I on Rac1 activation.", "entity1": "Rac1", "entity2": "N-acetyl l-cysteine", "span1": [134, 138], "span2": [18, 37]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15142": {"label": 9, "data": {"text": "However, there were detectable concentrations of Lhcgr, Cyp11a1 and Cyp17a1 mRNAs but undetectable concentrations of Insl3, Hsd17b3 and Hsd11b1 in the DEHP-treated testes, indicating that these 3\u03b2-HSD(pos) cells were newly formed progenitor Leydig cells.", "entity1": "Insl3", "entity2": "DEHP", "span1": [117, 122], "span2": [151, 155]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11396": {"label": 3, "data": {"text": "Using whole-cell voltage clamp, we examined mibefradil block of four Na+ channel isoforms expressed in human embryonic kidney cells: Nav1.5 (cardiac), Nav1.4 (skeletal muscle), Nav1.2 (brain), and Nav1.7 (peripheral nerve).", "entity1": "Nav1.2", "entity2": "mibefradil", "span1": [177, 183], "span2": [44, 54]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10723": {"label": 1, "data": {"text": "The binding domain of barusiban differs from the binding domain of the agonists and the nonselective oxytocin receptor antagonist d(CH2)5[Tyr-(Me)2,Thr4,Orn8,Tyr9]vasotocin that has been used in previous studies.", "entity1": "oxytocin receptor", "entity2": "barusiban", "span1": [101, 118], "span2": [22, 31]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"124": {"label": 3, "data": {"text": "Again, inhibition of the actin-activated myosin Mg2+-ATPase and myosin filament assembly by felodipine and the p-chloro analogue could be reversed by raising the calmodulin concentration.", "entity1": "myosin", "entity2": "felodipine", "span1": [64, 70], "span2": [92, 102]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14553": {"label": 8, "data": {"text": "Fluorescence of the reporter dye is turned on by rapid removal of the quinone quencher, an event that immediately occurs only after highly selective, two-electron reduction of the sterically and conformationally restricted quinone substrate by the cancer-associated human NAD(P)H:quinone oxidoreductase isozyme 1 (hNQO1).", "entity1": "hNQO1", "entity2": "quinone", "span1": [314, 319], "span2": [223, 230]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"12505": {"label": 8, "data": {"text": "The results suggest that individuals with high Vmax beta 2-ADH and deficient in low-Km mitochondrial ALDH2, accounting for approximately 45% of the Chinese population, may end up with acetaldehyde accumulation during alcohol consumption, rendering them vulnerable to tissue injury caused by this highly reactive and toxic metabolite.", "entity1": "ALDH2", "entity2": "alcohol", "span1": [101, 106], "span2": [217, 224]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8723": {"label": 3, "data": {"text": "From the 10 isolated compounds, methyl-3,5-di-O-caffeoylquinate showed the most potent inhibition, with IC50 values of 0.30 and 0.67\u00a0\u03bcM for rAR and rhAR, respectively.", "entity1": "rhAR", "entity2": "methyl-3,5-di-O-caffeoylquinate", "span1": [148, 152], "span2": [32, 63]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2301": {"label": 5, "data": {"text": "The involvement of EP1 and EP2 receptors is indicated by studies with the EP1 selective agonist 17-phenyl trinor PGE2, and the EP2 selective agonist butaprost (which stimulate), as well as by studies with the antagonists SC-51089 (EP1 specific) and AH 6809 (EP1 and EP2 specific).", "entity1": "EP2", "entity2": "AH 6809", "span1": [266, 269], "span2": [249, 256]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 4, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2083": {"label": 8, "data": {"text": "Phenytoin is principally metabolized by CYP2C9, and both are probable substrates of the drug transporter P-glycoprotein.", "entity1": "drug transporter", "entity2": "Phenytoin", "span1": [88, 104], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, 8, -1, -1, -1, -1]},
+	"14398": {"label": 3, "data": {"text": "The specific PI3K inhibitor, wortmannin, blocked significantly EGF-induced cell migration and invasion.", "entity1": "EGF", "entity2": "wortmannin", "span1": [63, 66], "span2": [29, 39]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6042": {"label": 4, "data": {"text": "In addition several ligands known to act as agonists at either 5-HT2A or 5-HT2C receptors including 1-m-chlorophenylpiperazine (m-CPP), Ru 24969, MK 212 and SCH 23390 were also agonists in rat fundus whilst sumatriptan, renzapride and 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) were very weak or inactive.", "entity1": "5-HT2C", "entity2": "MK 212", "span1": [73, 79], "span2": [146, 152]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10551": {"label": 2, "data": {"text": "RA is known to induce expression of the Burkitt's lymphoma receptor 1 (BLR1) gene which propels RA-induced cell cycle arrest and differentiation of HL-60 human myeloblastic leukemia cells, motivating the present analysis of transcriptional regulation of blr1 expression by RA.", "entity1": "BLR1", "entity2": "RA", "span1": [71, 75], "span2": [0, 2]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"518": {"label": 4, "data": {"text": "Zolmitriptan (Zomig; formerly 311C90) is a novel 5-hydroxytryptamine (5HT)1B/1D receptor agonist with proven efficacy in the acute treatment of migraine with or without preceding aura.", "entity1": "5-hydroxytryptamine (5HT)1B/1D", "entity2": "Zomig", "span1": [49, 79], "span2": [14, 19]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11138": {"label": 1, "data": {"text": "For example, clozapine revealed a radioligand-independent value of 1.6 nM at the dopamine D4 receptor, agreeing with the value directly measured with [3H]-clozapine at D4.", "entity1": "D4", "entity2": "[3H]-clozapine", "span1": [168, 170], "span2": [150, 164]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11223": {"label": 1, "data": {"text": "The insulin responses to glucose, mitiglinide, tolbutamide, and glibenclamide in MIN6 cells after chronic mitiglinide, nateglinide, or repaglinide treatment were comparable to those after chronic tolbutamide and glibenclamide treatment.", "entity1": "insulin", "entity2": "glibenclamide", "span1": [4, 11], "span2": [212, 225]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1086": {"label": 3, "data": {"text": "Moreover, the rank order for potency in inhibiting acetylcholinesterase (ambenonium>neostigmine=physostigmine =tacrine>pyridostigmine=edrophonium=galanthamine >desoxypeganine>parathion>gramine) indicated that the most effective inhibitors of acetylcholinesterase also displaced [3H]-oxotremorine-M to the greatest extent.", "entity1": "acetylcholinesterase", "entity2": "desoxypeganine", "span1": [51, 71], "span2": [160, 174]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1170": {"label": 1, "data": {"text": "Binding experiments on mitiglinide, nateglinide, and repaglinide to SUR1 expressed in COS-1 cells revealed that they inhibit the binding of [3H]glibenclamide to SUR1 (IC50 values: mitiglinide, 280 nM; nateglinide, 8 microM; repaglinide, 1.6 microM), suggesting that they all share a glibenclamide binding site.", "entity1": "SUR1", "entity2": "glibenclamide", "span1": [161, 165], "span2": [283, 296]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1627": {"label": 9, "data": {"text": "However, chronic ethanol, as well as ethanol withdrawal failed to produce any significant alteration in the level of CREB protein in the nucleus accumbens.", "entity1": "CREB", "entity2": "ethanol", "span1": [117, 121], "span2": [17, 24]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"11931": {"label": 1, "data": {"text": "To evaluate whether fisetin regulates mTORC1 signaling, we investigated the phosphorylation and kinase activity of the 70-kDa ribosomal protein S6 kinase 1 (S6K1) and mTORC1 in 3T3-L1 preadipocytes.", "entity1": "70-kDa ribosomal protein S6 kinase 1", "entity2": "fisetin", "span1": [119, 155], "span2": [20, 27]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2254": {"label": 1, "data": {"text": "In general, rifampicin can act on a pattern: rifampicin activates the nuclear pregnane X receptor that in turn affects cytochromes P450, glucuronosyltransferases and p-glycoprotein activities.", "entity1": "p-glycoprotein", "entity2": "rifampicin", "span1": [166, 180], "span2": [45, 55]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3359": {"label": 3, "data": {"text": "Despite the structural similarity between benzothiazepines and BDZs, mutation of an amino acid important for diltiazem potency (I1150A) did not affect diazepam potency.", "entity1": "I1150A", "entity2": "diazepam", "span1": [128, 134], "span2": [151, 159]}, "weak_labels": [0, -1, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"9467": {"label": 1, "data": {"text": "The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for IP, and S-145, I-BOP and GR 32191 for TP.", "entity1": "DP", "entity2": "BW245C", "span1": [164, 166], "span2": [142, 148]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5705": {"label": 3, "data": {"text": "We previously demonstrated that developmental exposure to a mixture of polychlorinated biphenyls (PCBs) which was reconstituted according to the congener pattern found in human breast milk caused feminization of sweet preference as a sexually dimorphic behavior in adult male rats, following decreases in aromatase activity in the brain of newborn male pups.", "entity1": "aromatase", "entity2": "polychlorinated biphenyls", "span1": [305, 314], "span2": [71, 96]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4123": {"label": 0, "data": {"text": "The cellular prion protein PrP(C) consists of two domains--a flexible N-terminal domain, which participates in copper and zinc regulation, and a largely helical C-terminal domain that converts to \u03b2 sheet in the course of prion disease.", "entity1": "prion protein PrP(C)", "entity2": "C", "span1": [13, 33], "span2": [161, 162]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1]},
+	"3360": {"label": 3, "data": {"text": "Although L-VGCC inhibition by BDZs occurred at concentrations that are possibly too high to be clinically relevant and is not likely to play a role in the up-regulation of L-VGCCs during long-term treatment, pentobarbital and ethanol inhibited L-VGCCs at clinically relevant concentrations.", "entity1": "L-VGCC", "entity2": "BDZs", "span1": [9, 15], "span2": [30, 34]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"13494": {"label": 1, "data": {"text": "The role of genetic variation in SLC6A4 on weight loss in response to sibutramine deserves further study.", "entity1": "SLC6A4", "entity2": "sibutramine", "span1": [33, 39], "span2": [70, 81]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5884": {"label": 0, "data": {"text": "The pyridoxal 5'-phosphate binding lysine in mouse ODC was identified as lysine 69 of the mouse sequence by reduction of the purified holoenzyme form with NaB[3H]4 followed by digestion of the carboxymethylated protein with endoproteinase Lys-C, radioactive peptide mapping using reversed-phase high pressure liquid chromatography and gas-phase peptide sequencing.", "entity1": "mouse ODC", "entity2": "lysine", "span1": [45, 54], "span2": [73, 79]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1394": {"label": 3, "data": {"text": "However, DeltahPPAR-alpha was unable to abrogate gemfibrozil-mediated inhibition of iNOS suggesting that gemfibrozil inhibits iNOS independent of PPAR-alpha.", "entity1": "iNOS", "entity2": "gemfibrozil", "span1": [84, 88], "span2": [49, 60]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2940": {"label": 1, "data": {"text": "Reported here is a crystal structure of the fully active and nonmutated PDE5A1 catalytic domain in complex with vardenafil.", "entity1": "PDE5A1 catalytic domain", "entity2": "vardenafil", "span1": [72, 95], "span2": [112, 122]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14373": {"label": 3, "data": {"text": "Furthermore, the EGFR inhibitor AG1478 inhibited EGF-induced MMP-9 expression, cell migration and invasion, as well as the activation of PI3K/Akt, suggesting that PI3K/Akt activation occur downstream of EGFR activation.", "entity1": "MMP-9", "entity2": "AG1478", "span1": [61, 66], "span2": [32, 38]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13557": {"label": 3, "data": {"text": "Using this assay, we found that both superoxide and nitric oxide inhibit renal cortical DDAH activity in vitro.", "entity1": "DDAH", "entity2": "superoxide", "span1": [88, 92], "span2": [37, 47]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6230": {"label": 1, "data": {"text": "Kinetic studies comparing the binding of [3H]eletriptan and [3H]sumatriptan to the human recombinant 5-HT1B and 5-HT1D receptors expressed in HeLa cells revealed that both radioligands bound with high specificity (>90%) and reached equilibrium within 10-15 min.", "entity1": "5-HT1D", "entity2": "[3H]sumatriptan", "span1": [112, 118], "span2": [60, 75]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11988": {"label": 8, "data": {"text": "Cyclooxygenase(COX)-2-derived prostanoids can influence several processes that are linked to carcinogenesis.", "entity1": "Cyclooxygenase(COX)-2", "entity2": "prostanoids", "span1": [0, 21], "span2": [30, 41]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1775": {"label": 2, "data": {"text": "(3)H-CGP 12177A saturation binding, in the presence of propranolol, increased approximately 5-fold following overexpression of beta(1)-adrenoceptors.", "entity1": "beta(1)-adrenoceptors", "entity2": "propranolol", "span1": [127, 148], "span2": [55, 66]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15144": {"label": 9, "data": {"text": "However, there were detectable concentrations of Lhcgr, Cyp11a1 and Cyp17a1 mRNAs but undetectable concentrations of Insl3, Hsd17b3 and Hsd11b1 in the DEHP-treated testes, indicating that these 3\u03b2-HSD(pos) cells were newly formed progenitor Leydig cells.", "entity1": "Hsd11b1", "entity2": "DEHP", "span1": [136, 143], "span2": [151, 155]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15655": {"label": 3, "data": {"text": "Cholesterol also increases Amyloid \u03b2 (A\u03b2) deposition and tau pathology.", "entity1": "A\u03b2", "entity2": "Cholesterol", "span1": [38, 40], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3677": {"label": 3, "data": {"text": "Furthermore, cAMP production and protein kinase A (PKA) activity were suppressed by artemisinic acid.", "entity1": "PKA", "entity2": "artemisinic acid", "span1": [51, 54], "span2": [84, 100]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"3412": {"label": 3, "data": {"text": "NFAT cooperates with c-Jun, a compound of the AP-1 complex, to activate target genes, and we also found that PSE inhibited both JNK activation and AP-1 transcriptional activity.", "entity1": "AP-1", "entity2": "PSE", "span1": [147, 151], "span2": [109, 112]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9643": {"label": 3, "data": {"text": "Down-regulation of prostate-specific antigen (PSA) expression, an AR-target gene, by estramustine and bicalutamide was accompanied by the blockade of the mutated androgen receptor.", "entity1": "androgen receptor", "entity2": "bicalutamide", "span1": [162, 179], "span2": [102, 114]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3358": {"label": 9, "data": {"text": "Although L-VGCC inhibition by BDZs occurred at concentrations that are possibly too high to be clinically relevant and is not likely to play a role in the up-regulation of L-VGCCs during long-term treatment, pentobarbital and ethanol inhibited L-VGCCs at clinically relevant concentrations.", "entity1": "L-VGCCs", "entity2": "BDZs", "span1": [172, 179], "span2": [30, 34]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"11243": {"label": 3, "data": {"text": "The clinical profile of the angiotensin II receptor blocker eprosartan.", "entity1": "angiotensin II receptor", "entity2": "eprosartan", "span1": [28, 51], "span2": [60, 70]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14176": {"label": 0, "data": {"text": "Mass spectral analysis of CBDP-inhibited BChE digested with Glu-C showed an o-hydroxybenzyl adduct (+106amu) on lysine 499, a residue far from the active site, but not on His-438.", "entity1": "BChE", "entity2": "lysine", "span1": [41, 45], "span2": [112, 118]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"8685": {"label": 3, "data": {"text": "Recently, the c-Abl kinase inhibitor imatinib mesylate (imatinib) has become the focus of research as a fertoprotective drug against cisplatin.", "entity1": "kinase", "entity2": "imatinib", "span1": [20, 26], "span2": [56, 64]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9011": {"label": 1, "data": {"text": "These findings suggest that limitation of SRF was produced by binding of BDZs, but not beta CCs, to voltage-dependent sodium channels and not to high affinity central BDZ receptors, and that BDZs limit SRF by slowing recovery of sodium channels from inactivation.", "entity1": "BDZ receptors", "entity2": "BDZs", "span1": [167, 180], "span2": [73, 77]}, "weak_labels": [-1, -1, -1, 1, -1, 1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, 9]},
+	"871": {"label": 8, "data": {"text": "Depletion of putrescine, spermidine, and spermine by DL-alpha-difluoromethylornithine (DFMO), a specific inhibitor of ornithine decarboxylase (ODC) that is the first rate-limiting enzyme for polyamine biosynthesis, decreased the apoptotic index.", "entity1": "ornithine decarboxylase", "entity2": "spermidine", "span1": [118, 141], "span2": [25, 35]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12307": {"label": 1, "data": {"text": "It was hypothesized that because Hg accumulates in the proximal tubules (PTs), glutathione-S-transferases (GST)-\u03b1 (suggestive of kidney damage at the level of PT) would be expected to be more related to Hg exposure than GST-\u03c0 (suggestive of kidney damage at the level of the distal tubules).", "entity1": "GST-\u03c0", "entity2": "Hg", "span1": [220, 225], "span2": [203, 205]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8750": {"label": 8, "data": {"text": "Kinetic analyses revealed that the affinity and clearance of UGT2B10 for amitriptyline, imipramine, and diphenhydramine are significantly higher than the corresponding values of UGT1A4 and UGT1A3, although the Vmax values of UGT1A4 toward these drugs are considerably higher.", "entity1": "UGT2B10", "entity2": "amitriptyline", "span1": [61, 68], "span2": [73, 86]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4199": {"label": 3, "data": {"text": "Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway.", "entity1": "JAK2", "entity2": "Pterostilbene", "span1": [91, 95], "span2": [0, 13]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13852": {"label": 3, "data": {"text": "As discussed in this review, various progestogens including dydrogesterone and its 20alpha-dihydro-derivative, medrogestone, promegestone, nomegestrol acetate and norelgestromin can reduce intratissular levels of estradiol in breast cancer by blocking sulfatase and 17beta-hydroxysteroid-dehydrogenase type 1 activities.", "entity1": "17beta-hydroxysteroid-dehydrogenase type 1", "entity2": "nomegestrol acetate", "span1": [266, 308], "span2": [139, 158]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8296": {"label": 3, "data": {"text": "LY294002, a specific PI3K/AKT inhibitor, selectively activated the p38 MAPK kinase pathway and enhanced c-Jun phosphorylation, but did not activate JNK.", "entity1": "PI3K", "entity2": "LY294002", "span1": [21, 25], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"2439": {"label": 3, "data": {"text": "Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium.", "entity1": "cyclooxygenase", "entity2": "bromfenac sodium", "span1": [14, 28], "span2": [116, 132]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3066": {"label": 1, "data": {"text": "The effects of PLZ on both amino acids and their transaminases were blocked by pre-treatment with the MAO inhibitor tranylcypromine.", "entity1": "transaminases", "entity2": "PLZ", "span1": [49, 62], "span2": [15, 18]}, "weak_labels": [0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12055": {"label": 1, "data": {"text": "Our results demonstrated that acute As(III) treatment (12.5\u2009mg/kg) altered CYP epoxygenases, CYP \u03c9-hydroxylases and EPHX2 mRNA levels that were isozyme and tissue specific.", "entity1": "CYP", "entity2": "As(III)", "span1": [93, 96], "span2": [36, 43]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4386": {"label": 1, "data": {"text": "Camptothecin (CPT), a topoisomerase (Top) I-targeting drug that stabilizes Top1-DNA covalent adducts, can induce S-phase-specific cytotoxicity due to the arrest of progressing replication forks.", "entity1": "topoisomerase (Top) I", "entity2": "CPT", "span1": [22, 43], "span2": [14, 17]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1143": {"label": 3, "data": {"text": "ZD1839 (\"Iressa\"), a quinazoline tyrosine kinase inhibitor selective for the EGFR, has shown good activity in preclinical studies and in the early phase of clinical trials.", "entity1": "EGFR", "entity2": "ZD1839", "span1": [77, 81], "span2": [0, 6]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7971": {"label": 2, "data": {"text": "Diet, physical exercise and Orlistat administration increase serum Anti-M\u00fcllerian Hormone (AMH) levels in women with polycystic ovary syndrome (PCOS).", "entity1": "AMH", "entity2": "Orlistat", "span1": [91, 94], "span2": [28, 36]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9564": {"label": 2, "data": {"text": "The observed inhibition on IFN-gamma, GM-CSF, and IL-3 mRNA was blocked by the selective beta2AR antagonist ICI 118,551 (10(-6) M) and by timolol (10(-6) M), a nonselective antagonist.", "entity1": "IL-3", "entity2": "timolol", "span1": [50, 54], "span2": [138, 145]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10123": {"label": 5, "data": {"text": "A nicotinic receptor antagonist (hexamethonium) attenuated the contraction in part and an alpha-adrenoceptor antagonist (prazosin) nearly abolished the contraction.", "entity1": "nicotinic receptor", "entity2": "hexamethonium", "span1": [2, 20], "span2": [33, 46]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2729": {"label": 3, "data": {"text": "Indomethacin and SC-236, a selective cyclooxygenase-2 (COX-2) inhibitor, exerted a similar effect as sulindac.", "entity1": "cyclooxygenase-2", "entity2": "SC-236", "span1": [37, 53], "span2": [17, 23]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10250": {"label": 9, "data": {"text": "A moderate (twofold) stimulation of CD62P expression by abciximab but not by tirofiban or eptifibatide was observed in one patient.", "entity1": "CD62P", "entity2": "tirofiban", "span1": [36, 41], "span2": [77, 86]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"14289": {"label": 9, "data": {"text": "Valpromide (VPD), the amide derivative of VPA, does not inhibit HDAC activity and is a weak teratogen in vivo.", "entity1": "HDAC", "entity2": "amide", "span1": [64, 68], "span2": [22, 27]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"10187": {"label": 3, "data": {"text": "In complementary RNA (cRNA)-injected Xenopus laevis oocytes, rifamycin SV (10 micromol/L) cis-inhibited human organic anion transporting polypeptide C (SLC21A6) (OATP-C), human organic anion transporting polypeptide 8 (SLC21A8) (OATP8), human organic anion transporting polypeptide B (SLC21A9) (OATP-B), and human organic anion transporting polypeptide A (SLC21A3) (OATP-A) mediated BSP uptake by 69%, 79%, 89%, and 57%, respectively, as compared with uptake into control oocytes.", "entity1": "OATP-A", "entity2": "rifamycin SV", "span1": [366, 372], "span2": [61, 73]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"10356": {"label": 1, "data": {"text": "Investigation of bradykinin metabolism in human and rat plasma in the presence of the dual ACE/NEP inhibitors GW660511X and omapatrilat.", "entity1": "bradykinin", "entity2": "omapatrilat", "span1": [17, 27], "span2": [124, 135]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5740": {"label": 3, "data": {"text": "Perinatal exposure to BDE-99 causes learning disorders and decreases serum thyroid hormone levels and BDNF gene expression in hippocampus in rat offspring.", "entity1": "BDNF", "entity2": "BDE-99", "span1": [102, 106], "span2": [22, 28]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14192": {"label": 1, "data": {"text": "CCAAT/Enhancer-binding protein-homologous protein sensitizes to SU5416 by modulating p21 and PI3K/Akt signal pathway in FRO anaplastic thyroid carcinoma cells.", "entity1": "CCAAT/Enhancer-binding protein-homologous protein", "entity2": "SU5416", "span1": [0, 49], "span2": [64, 70]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14483": {"label": 8, "data": {"text": "The obtained results indicate that rat brain CYP2D isoforms catalyze the formation of serotonin from 5-methoxytryptamine, and that the deficit or genetic defect of CYP2D may affect serotonin metabolism in the brain.", "entity1": "rat brain CYP2D", "entity2": "serotonin", "span1": [35, 50], "span2": [86, 95]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"9369": {"label": 3, "data": {"text": "We show that the binding of thalidomide photoaffinity label to authentic human AGP is competed with both thalidomide and the nonradioactive photoaffinity label at concentrations comparable to those required for inhibition of production of tumor necrosis factor alpha from human monocytes, suggesting that AGP may be involved in the immunomodulatory activity of thalidomide.", "entity1": "tumor necrosis factor alpha", "entity2": "thalidomide", "span1": [239, 266], "span2": [105, 116]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, 6, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"6427": {"label": 3, "data": {"text": "Pretreating mice with schisandrin B (Sch B), a dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chinensis, at a daily dose of 1 mmol/kg for 3 days protected against menadione-induced hepatic oxidative damage in mice, as evidenced by decreases in plasma alanine aminotransferase activity (78%) and hepatic malondialdehyde level (70%), when compared with the menadione intoxicated control.", "entity1": "alanine aminotransferase", "entity2": "menadione", "span1": [275, 299], "span2": [187, 196]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"12381": {"label": 1, "data": {"text": "Methods: Cocktail approach was used to evaluate the influence of IR and IPC on the activities of CYP1A2, CYP2C9, CYP2E1, CYP2D6 and CYP3A4, which were reflected by the changes of pharmacokinetic parameters of five specific probe drugs: caffeine, chlorzoxazone, tolbutamide, metoprolol and midazolam, respectively.", "entity1": "CYP3A4", "entity2": "midazolam", "span1": [132, 138], "span2": [289, 298]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11756": {"label": 1, "data": {"text": "Around five times as potent as the lead with an IC(50) of 33 \u03bcM for disruption of the Myc-Max heterodimer, JY-3-094 demonstrated excellent selectivity over Max-Max homodimers, with no apparent effect at 100 \u03bcM.", "entity1": "Max", "entity2": "JY-3-094", "span1": [160, 163], "span2": [107, 115]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13637": {"label": 0, "data": {"text": "Crystallographic data reveal that a conserved Gly residue (located at the juncture between the linker and C-terminal domains) is at one end of a short alpha-helix, which extends to the active site Tyr covalently linked to the DNA.", "entity1": "alpha-helix", "entity2": "Gly", "span1": [151, 162], "span2": [46, 49]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3627": {"label": 4, "data": {"text": "Methanandamide (10.0 mg/kg) had lesser effect than other CB agonists, and the CB2 agonist AM1241 [1-(methylpiperidin-2-ylmethyl)-3-(2-iodo-5-nitrobenzoyl)indole], the anandamide transport inhibitor AM404, and the CB antagonist rimonabant did not have diuretic effects.", "entity1": "CB2", "entity2": "1-(methylpiperidin-2-ylmethyl)-3-(2-iodo-5-nitrobenzoyl)indole", "span1": [78, 81], "span2": [98, 160]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, 4, 5, -1, -1, -1, -1, 8, -1, -1, -1, 9]},
+	"11797": {"label": 3, "data": {"text": "Fisetin treatment showed a significant decline in the levels of blood glucose, glycosylated hemoglobin (HbA1c), NF-kB p65 unit (in pancreas) and IL-1\u03b2 (plasma), serum nitric oxide (NO) with an elevation in plasma insulin.", "entity1": "p65", "entity2": "Fisetin", "span1": [118, 121], "span2": [0, 7]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10772": {"label": 2, "data": {"text": "Imatinib stimulated the rapid release of soluble HB-EGF and the subsequent induction of membrane-bound HB-EGF, which correlated with biphasic MAPK activation.", "entity1": "HB-EGF", "entity2": "Imatinib", "span1": [49, 55], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5779": {"label": 1, "data": {"text": "Inhibition of binding of both plasminogen and plasmin to gp330 by benzamidine was similar, although EACA inhibited the binding of plasmin to gp330 slightly more than the binding of plasminogen to gp330.", "entity1": "gp330", "entity2": "EACA", "span1": [141, 146], "span2": [100, 104]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3841": {"label": 1, "data": {"text": "Arsenic activates endothelin-1 Gi protein-coupled receptor signaling to inhibit stem cell differentiation in adipogenesis.", "entity1": "endothelin-1", "entity2": "Arsenic", "span1": [18, 30], "span2": [0, 7]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10488": {"label": 5, "data": {"text": "The aim of this study was, therefore, to provide comparative binding characteristics of agonists (epinephrine, norepinephrine, isoproterenol, fenoterol, salbutamol, salmeterol, terbutalin, formoterol, broxaterol) and antagonists (propranolol, alprenolol, atenolol, metoprolol, bisoprolol, carvedilol, pindolol, BRL 37344, CGP 20712, SR 59230A, CGP 12177, ICI 118551) at all three subtypes of human beta-adrenergic receptors in an identical cellular background.", "entity1": "human beta-adrenergic receptors", "entity2": "atenolol", "span1": [392, 423], "span2": [255, 263]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, 5, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"9428": {"label": 1, "data": {"text": "PTP inhibition by hisphosphonates or vanadate was diminished by the metal chelating agent EDTA, or by the reducing agent dithiothreitol, suggesting that a metal ion and the oxidation of a cysteine residue are required for full inhibition.", "entity1": "PTP", "entity2": "dithiothreitol", "span1": [0, 3], "span2": [121, 135]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13688": {"label": 1, "data": {"text": "Porcine TLR8 and TLR7 are both activated by a selective TLR7 ligand, imiquimod.", "entity1": "TLR7", "entity2": "imiquimod", "span1": [56, 60], "span2": [69, 78]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14831": {"label": 3, "data": {"text": "Although parenteral oral direct thrombin inhibitors (DTIs), such as argatroban and bivalirudin, have been on the market for years, DTIs such as dabigatran are novel synthetic thrombin antagonists.", "entity1": "thrombin", "entity2": "argatroban", "span1": [32, 40], "span2": [68, 78]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4003": {"label": 3, "data": {"text": "Further, compared with vemurafenib, another BRAF(V600E) inhibitor, dabrafenib showed greater brain penetration with a similar dose.", "entity1": "V600E", "entity2": "vemurafenib", "span1": [49, 54], "span2": [23, 34]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"3518": {"label": 3, "data": {"text": "TZD effects on osteoblast viability, oleic acid uptake, alkaline phosphatase and osteocalcin production are independent of their effects on aromatase.", "entity1": "aromatase", "entity2": "TZD", "span1": [140, 149], "span2": [0, 3]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"12776": {"label": 1, "data": {"text": "Thymidylate synthase (TS) continues to be a critical target for 5-fluorouracil (5-FU) and its prodrugs, UFT/LV (Orzel), capecitabine (Xeloda), and S-1, primarily because this enzyme is essential for the synthesis of 2-deoxythymidine-5-monophosphate, a precursor for DNA synthesis.", "entity1": "TS", "entity2": "Orzel", "span1": [22, 24], "span2": [112, 117]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11444": {"label": 1, "data": {"text": "Effect of thalidomide on COX-1 and COX-2 in vivo was consistent with that of in vitro.", "entity1": "COX-1", "entity2": "thalidomide", "span1": [25, 30], "span2": [10, 21]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2638": {"label": 1, "data": {"text": "Exogenous all-trans-retinol, all-trans-13,14-dihydroretinol, or all-trans-7,8-dihydroretinol led to the strong induction of the expression of the retinoic acid-metabolizing enzyme, Cyp26A1, arguing for an active signaling function of dihydroretinoid metabolites in zebrafish.", "entity1": "Cyp26A1", "entity2": "all-trans-13,14-dihydroretinol", "span1": [181, 188], "span2": [29, 59]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12185": {"label": 1, "data": {"text": "To probe into the \"logic\" of this enigma, we have started comparative studies among evolutionarily distant organisms, such as mouse and Saccharomyces cerevisiae, and we are now looking for biotin effects on specific genes and proteins, such as HCS and hexokinases, and on their proteomes.", "entity1": "hexokinases", "entity2": "biotin", "span1": [252, 263], "span2": [189, 195]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3847": {"label": 1, "data": {"text": "Using the viral mimic polyinosinic:polycytidylic acid and the IFN\u03b1/\u03b2 antagonist B18R we furthermore demonstrate the capability of endogenous IFN to promote IL-22-induced STAT1 activation and expression of CXCL10.", "entity1": "IL-22", "entity2": "polyinosinic:polycytidylic acid", "span1": [156, 161], "span2": [22, 53]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13173": {"label": 2, "data": {"text": "These results highlight the importance of PR activation of the Src/MAPK signaling pathway for progesterone-induced transcription of select target genes and cell cycle progression.", "entity1": "MAPK", "entity2": "progesterone", "span1": [67, 71], "span2": [94, 106]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9167": {"label": 7, "data": {"text": "Phenylbutazone (PB), a nonsteroidal anti-inflammatory drug, is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS).", "entity1": "prostaglandin H synthase", "entity2": "Phenylbutazone", "span1": [125, 149], "span2": [0, 14]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, 7, -1, -1, -1, -1, -1, -1]},
+	"13907": {"label": 9, "data": {"text": "Phenformin but not metformin inhibits a number of variants of K(ATP) including the cloned equivalents of currents present in vascular and non-vascular smooth muscle (Kir6.1/SUR2B and Kir6.2/SUR2B) and pancreatic beta-cells (Kir6.2/SUR1).", "entity1": "Kir6.2", "entity2": "metformin", "span1": [224, 230], "span2": [19, 28]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"5461": {"label": 2, "data": {"text": "RESULTS: Fractionated bulb extracts and the two isolated steroidal glycoalkaloids (1) and (2) induced NO production and TGF-\u03b2 receptor I mRNA expression in fibroblast cell culture.", "entity1": "TGF-\u03b2 receptor I", "entity2": "steroidal glycoalkaloids", "span1": [120, 136], "span2": [57, 81]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"8045": {"label": 3, "data": {"text": "Exposure of H9c2 cells to high glucose reduced AMPK activity, inhibited Jun NH2-terminal kinase 1 (JNK1)-B-cell lymphoma 2 (Bcl-2) signaling, and promoted Beclin1 binding to Bcl-2.", "entity1": "JNK1", "entity2": "glucose", "span1": [99, 103], "span2": [31, 38]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1809": {"label": 3, "data": {"text": "In this study, we have synthesized novel alpha-hydroxyphenylamide analogues of diphenylhydantoin and examined their ability to inhibit human Na(V)1.5 sodium channels expressed in Chinese Hamster Ovary (CHO-K1) cells.", "entity1": "sodium channels", "entity2": "alpha-hydroxyphenylamide", "span1": [150, 165], "span2": [41, 65]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7686": {"label": 3, "data": {"text": "We discovered sergliflozin etabonate, a novel selective SGLT2 inhibitor, and found that selective inhibition of SGLT2 increased urinary glucose excretion and consequently decreased plasma glucose levels.", "entity1": "SGLT2", "entity2": "sergliflozin etabonate", "span1": [112, 117], "span2": [14, 36]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9890": {"label": 1, "data": {"text": "A similar discrepancy in sensitivity to competitors between 3H-NMPB and 3H-QNB was also observed when biperiden was used as a competitor, indicating that binding to different subtypes of the mAch receptor could not account for the observed differences in sensitivity to competition.", "entity1": "mAch receptor", "entity2": "3H-NMPB", "span1": [191, 204], "span2": [60, 67]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"9216": {"label": 1, "data": {"text": "We have found that certain naphthalenesulfonamides [e.g., N-6(-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7)] and phenothiazines [e.g., trifluoperazine (TFP)] induce a loss of cell-surface receptors for alpha 2-macroglobulin, and epidermal growth factor (EGF) in fibroblasts.", "entity1": "epidermal growth factor", "entity2": "TFP", "span1": [236, 259], "span2": [159, 162]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"13009": {"label": 1, "data": {"text": "Phospholipase C beta (PLC-beta)-coupled G protein-coupled receptor (GPCR) activities traditionally are assessed by measuring Ca2+ triggered by D-myo-inositol 1,4,5-trisphosphate (IP3), a PLC-beta hydrolysis product, or by measuring the production of inositol phosphate using cumbersome radioactive assays.", "entity1": "GPCR", "entity2": "D-myo-inositol 1,4,5-trisphosphate", "span1": [68, 72], "span2": [143, 177]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"12054": {"label": 1, "data": {"text": "Our results demonstrated that acute As(III) treatment (12.5\u2009mg/kg) altered CYP epoxygenases, CYP \u03c9-hydroxylases and EPHX2 mRNA levels that were isozyme and tissue specific.", "entity1": "epoxygenases", "entity2": "As(III)", "span1": [79, 91], "span2": [36, 43]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3993": {"label": 3, "data": {"text": "In addition, BGG-mediated inhibition of AR prevented LPS-induced activation of JNK and p38 and lowered ROS levels, which could inhibit LPS-induced apoptosis.", "entity1": "AR", "entity2": "BGG", "span1": [40, 42], "span2": [13, 16]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1318": {"label": 3, "data": {"text": "Valdecoxib is a potent and specific inhibitor of cyclooxygenase-2, which is used for the treatment of rheumatoid arthritis, osteoarthritis, and the dysmenorrhea pain.", "entity1": "cyclooxygenase-2", "entity2": "Valdecoxib", "span1": [49, 65], "span2": [0, 10]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3933": {"label": 2, "data": {"text": "The reactivation of brain AChE inhibited with tabun demonstrated better activity of new compound BT-07-4M, TMB-4 and obidoxime from symmetric oximes, and BT-05 and BT-03 possessing asymmetric structure.", "entity1": "AChE", "entity2": "TMB-4", "span1": [26, 30], "span2": [107, 112]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14927": {"label": 1, "data": {"text": "However, other steroids, including \u0394(5)-androstenediol, 5\u03b1-androstanediol and 27-hydroxycholesterol, which have a saturated A ring containing a 3\u03b2-hydroxyl and a C19 methyl group, also mediate physiological responses through binding to estrogen receptor-\u03b1 (ER\u03b1) and ER\u03b2.", "entity1": "estrogen receptor-\u03b1", "entity2": "methyl", "span1": [236, 255], "span2": [166, 172]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6076": {"label": 0, "data": {"text": "Within the conserved transmembrane domains, the sequences exhibit approximately 52%, 59%, 65%, and 68% amino acid identity with the known rat 5-HT1A, rat 5-HT1B, rat 5-HT1D, and human 5-HT1E receptors, respectively.", "entity1": "human 5-HT1E", "entity2": "amino acid", "span1": [178, 190], "span2": [103, 113]}, "weak_labels": [0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5638": {"label": 2, "data": {"text": "AMPK activators metformin and AICAR partly prevented the cell cycle block, oxidative stress and apoptosis induced by compound C. The small interfering RNA (siRNA) targeting of human AMPK mimicked compound C-induced G(2)/M cell cycle arrest, but failed to induce oxidative stress and apoptosis in U251 glioma cells.", "entity1": "AMPK", "entity2": "metformin", "span1": [0, 4], "span2": [16, 25]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8448": {"label": 2, "data": {"text": "l-glutamine decreased plasma glucose, increased plasma and pancreatic insulin, increased plasma and colonic active GLP-1 (7-36) amide secretion as well as decreased oxidative stress in streptozotocin-nicotinamide induced diabetic rats.", "entity1": "GLP-1", "entity2": "l-glutamine", "span1": [115, 120], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7781": {"label": 2, "data": {"text": "In TPC1, BCPAP, FRO, WRO cell lines PJ34 induced a strong increase in NIS mRNA levels.", "entity1": "NIS", "entity2": "PJ34", "span1": [70, 73], "span2": [36, 40]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6285": {"label": 3, "data": {"text": "Concentration-response curves for the inhibition of monocyte COX-2 and platelet COX-1 were obtained in vitro after the incubation of meloxicam with whole blood samples.", "entity1": "COX-1", "entity2": "meloxicam", "span1": [80, 85], "span2": [133, 142]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"525": {"label": 2, "data": {"text": "Treatment of Rat-2 fibroblast cells with C2-ceramide caused the stimulation of c-fos SRE-dependent reporter gene activity in a dose- and time-dependent manner by transient transfection analysis.", "entity1": "c-fos SRE", "entity2": "C2-ceramide", "span1": [79, 88], "span2": [41, 52]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15688": {"label": 3, "data": {"text": "Treatment with EVn-50 or VB1 resulted in arresting the MDA-MB-435 and SMMC-7721 cells at G2/M phase, which was further supported by observations of increased phosphorylation of Histone 3 at Ser10, phosphorylation of Cdk1 at Tyr15, expression of cyclin B1, and decreased expression of Cdc25c.", "entity1": "Cdc25c", "entity2": "VB1", "span1": [284, 290], "span2": [25, 28]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"630": {"label": 3, "data": {"text": "Likewise, IL-2 steady-state mRNA expression was inhibited by both PLA2 inhibitors in a concentration-dependent fashion with > 90% inhibition at 1 microM BPB and 20 microM AACOCF3.", "entity1": "PLA2", "entity2": "AACOCF3", "span1": [66, 70], "span2": [171, 178]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4185": {"label": 0, "data": {"text": "Here we show that TRF2 specifically interacts with the histone acetyltransferase p300, and that p300 acetylates the lysine residue at position 293 of TRF2.", "entity1": "TRF2", "entity2": "lysine", "span1": [150, 154], "span2": [116, 122]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4968": {"label": 3, "data": {"text": "One exception is tranexamic acid (TXA), which, as a lysine mimetic, inhibits binding of plasminogen to fibrin.", "entity1": "plasminogen", "entity2": "TXA", "span1": [88, 99], "span2": [34, 37]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9714": {"label": 1, "data": {"text": "A novel mutation of the erythroid-specific gamma-Aminolevulinate synthase gene in a patient with non-inherited pyridoxine-responsive sideroblastic anemia.", "entity1": "erythroid-specific gamma-Aminolevulinate synthase", "entity2": "pyridoxine", "span1": [24, 73], "span2": [111, 121]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2027": {"label": 3, "data": {"text": "INTRODUCTION: The principal aim of this study was to assess the efficacy of quinidine in suppressing IKr in vitro and in modulating the rate dependence of the QT interval in the \"SQT1\" form of the short QT syndrome.", "entity1": "IKr", "entity2": "quinidine", "span1": [101, 104], "span2": [76, 85]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9434": {"label": 3, "data": {"text": "Alendronate inhibited PTPmeg1 with an IC50 value of 23 microM, PTPsigma with an IC50 value of 2 microM, and did not inhibit PTP epsilon at concentrations up to 1 mM.", "entity1": "PTPsigma", "entity2": "Alendronate", "span1": [63, 71], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"10961": {"label": 3, "data": {"text": "Miglustat, an imino sugar that reversibly inhibits glucosylceramide synthase and reduces intracellular substrate burden, is an oral treatment for patients with type 1 GD that was recently approved in the United States for symptomatic patients with mild to moderate clinical manifestations for whom ERT is not an option.", "entity1": "glucosylceramide synthase", "entity2": "imino sugar", "span1": [51, 76], "span2": [14, 25]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, 9]},
+	"15461": {"label": 8, "data": {"text": "Measurement of Transport Activities of 3\u03b2-Hydroxy-\u0394(5)-bile Acids in Bile Salt Export Pump and Multidrug Resistance-Associated Proteins Using LC-MS/MS.", "entity1": "Bile Salt Export Pump", "entity2": "3\u03b2-Hydroxy-\u0394(5)-bile Acids", "span1": [69, 90], "span2": [39, 65]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"13614": {"label": 3, "data": {"text": "Sorafenib and sunitinib are synthetic, orally active agents shown to directly inhibit vascular endothelial growth factor receptors -2 and -3 (VEGFR-2, VEGFR-3) and platelet-derived growth factor receptor beta (PDGFR-beta), while temsirolimus is an mTOR inhibitor.", "entity1": "VEGFR-3", "entity2": "sunitinib", "span1": [151, 158], "span2": [14, 23]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1305": {"label": 2, "data": {"text": "The results reinforce previous assumptions that dopamine may interact with eicosanoid metabolism by means of D(2) receptor activation, and implicate an involvement of cPLA(2) and COX-2 in this effect.", "entity1": "D(2) receptor", "entity2": "dopamine", "span1": [109, 122], "span2": [48, 56]}, "weak_labels": [-1, -1, -1, -1, 1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10693": {"label": 3, "data": {"text": "Lumiracoxib is a highly selective COX-2 inhibitor with anti-inflammatory, analgesic and antipyretic activities comparable with diclofenac, the reference NSAID, but with much improved gastrointestinal safety.", "entity1": "COX-2", "entity2": "Lumiracoxib", "span1": [34, 39], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15094": {"label": 3, "data": {"text": "Ceftazidime-avibactam appears to be well tolerated in healthy subjects and hospitalized patients, with few serious drug-related treatment-emergent adverse events reported to date.In conclusion, avibactam serves to broaden the spectrum of ceftazidime versus \u00df-lactamase-producing Gram-negative bacilli.", "entity1": "\u00df-lactamase", "entity2": "avibactam", "span1": [257, 268], "span2": [194, 203]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"12405": {"label": 1, "data": {"text": "Moreover, Paeoniflorin promoted the nuclear translocation of nuclear factor erythroid 2 related factor-2 (Nrf-2).", "entity1": "Nrf-2", "entity2": "Paeoniflorin", "span1": [106, 111], "span2": [10, 22]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4512": {"label": 3, "data": {"text": "Diclofenac-\u03b2-d-glucuronide, clopidogrel-\u03b2-d-glucuronide, ibuprofen-\u03b2-d-glucuronide, (R)-naproxen-\u03b2-d-glucuronide, and (S)-naproxen-\u03b2-d-glucuronide selectively inhibited hCES1, with Ki values of 4.32 \u00b1 0.47, 24.8 \u00b1 4.2, 355 \u00b1 38, 468 \u00b1 21, 707 \u00b1 64 \u00b5M, respectively, but did not significantly inhibit hCES2.", "entity1": "hCES1", "entity2": "Diclofenac-\u03b2-d-glucuronide", "span1": [169, 174], "span2": [0, 26]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"9589": {"label": 5, "data": {"text": "These results indicate that carbetocin is a partial agonist/antagonist to the oxytocin receptor while the two metabolites carbetocin metabolite I and carbetocin metabolite II are pure antagonists.", "entity1": "oxytocin receptor", "entity2": "carbetocin", "span1": [78, 95], "span2": [28, 38]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1104": {"label": 3, "data": {"text": "Carvedilol reduced mortality and heart failure in patients with higher pre-treatment plasma N-BNP and adrenomedullin.", "entity1": "N-BNP", "entity2": "Carvedilol", "span1": [92, 97], "span2": [0, 10]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12428": {"label": 8, "data": {"text": "These studies show that CYP3A4 and CYP3A5 metabolize BDP to inactive metabolites and suggest that differences in the expression or function of these enzymes in the lung and/or liver could influence BDP disposition in humans.", "entity1": "CYP3A4", "entity2": "BDP", "span1": [24, 30], "span2": [53, 56]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7601": {"label": 4, "data": {"text": "In addition to OT and to a lesser extent AVP (pitressin), a number of OT and AVP analogues; such as carbetocin (OT agonist) dDAVP (desmopressin, V(2) agonist), terlipressin (V(1a) agonist), felypressin (V(1a) agonist) and atosiban (Tractocile OT antagonist) are also in clinical use.", "entity1": "V(1a)", "entity2": "felypressin", "span1": [203, 208], "span2": [190, 201]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11219": {"label": 1, "data": {"text": "The insulin responses to glucose, mitiglinide, tolbutamide, and glibenclamide in MIN6 cells after chronic mitiglinide, nateglinide, or repaglinide treatment were comparable to those after chronic tolbutamide and glibenclamide treatment.", "entity1": "insulin", "entity2": "mitiglinide", "span1": [4, 11], "span2": [106, 117]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9915": {"label": 2, "data": {"text": "4-chloro-6-[(2,3-xylidine)-pirimidinylthio] acetic acid (WY-14,643), a specific ligand of the PPAR-alpha subtype, causes the most dramatic increase in UCP-3 mRNA, whereas troglitazone, a specific activator of PPAR-gamma, also significantly increases UCP-3 mRNA abundance in skeletal muscle of lactating mice.", "entity1": "UCP-3", "entity2": "troglitazone", "span1": [250, 255], "span2": [171, 183]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15756": {"label": 3, "data": {"text": "CO donor dose-dependently inactivated CYP2E1 of ethanol-incubated microsome, which was mimicked by HO-1 substrate but abolished by CO scavenger.", "entity1": "CYP2E1", "entity2": "CO", "span1": [38, 44], "span2": [0, 2]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"12735": {"label": 3, "data": {"text": "Agents which have recently been shown to block cyclin D1 translation by regulating calcium levels are the unsaturated essential fatty acid, eicosapentaenoic acid (EPA), the antidiabetic thiazolidinediones, and the antifungal agent, clotrimazole.", "entity1": "cyclin D1", "entity2": "thiazolidinediones", "span1": [47, 56], "span2": [186, 204]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4990": {"label": 1, "data": {"text": "Phenobarbital (PB), a typical CAR activator, increased the gene expression of HIF-target genes in the livers of mice, including erythropoietin, heme oxygenase-1 and vascular endothelial growth factor-a.", "entity1": "HIF", "entity2": "Phenobarbital", "span1": [78, 81], "span2": [0, 13]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3828": {"label": 9, "data": {"text": "The inhibition of phosphoinositide 3-kinase using Ly294002 augmented a decrease in the p21 level induced by their combination, but it showed no significant effects on expression of Sp1 and cyclin D1.", "entity1": "cyclin D1", "entity2": "Ly294002", "span1": [189, 198], "span2": [50, 58]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1": {"label": 1, "data": {"text": "Labetalol and dilevalol (both at > or = 10(-7) M) attenuated the spontaneous contractile activity of the rat portal vein and the attenuation to labetalol at 10(-6) M was abolished by ICI 118,551 which illustrates that the labetalol-induced attenuation is beta 2-adrenoceptor mediated.", "entity1": "beta 2-adrenoceptor", "entity2": "ICI 118,551", "span1": [255, 274], "span2": [183, 194]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1133": {"label": 3, "data": {"text": "The antipsychotic drugs sertindole and pimozide are known to prolong the QT interval on the electrocardiogram via a high affinity block of the cardiac K(+) channel known as HERG (human ether-a-go-go-related gene; erg1).", "entity1": "HERG", "entity2": "pimozide", "span1": [173, 177], "span2": [39, 47]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13497": {"label": 0, "data": {"text": "Multiple rat brain calpastatin forms are produced by distinct starting points and alternative splicing of the N-terminal exons.", "entity1": "rat brain calpastatin", "entity2": "N", "span1": [9, 30], "span2": [110, 111]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"158": {"label": 5, "data": {"text": "Effects of ORF 17583, other histamine H2-receptor antagonists and omeprazole on gastric acid secretory states in rats and dogs.", "entity1": "histamine H2-receptor", "entity2": "ORF 17583", "span1": [28, 49], "span2": [11, 20]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8198": {"label": 3, "data": {"text": "In cultured cardiomyocytes, cardiomyocyte hypertrophy induced by the \u03b1(1)-agonist phenylephrine was inhibited by the overexpression of SIRT1 as well as resveratrol, both of which down-regulated p300 protein levels but not p300 mRNA levels.", "entity1": "p300", "entity2": "resveratrol", "span1": [194, 198], "span2": [152, 163]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, 3, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"8990": {"label": 3, "data": {"text": "Removing medium Ca2+, blocking Ca2+ channels with 50 mumol/l verapamil, or inhibiting calmodulin activation with 20 mumol/l trifluoperazine, 10 mumol/l chlorpromazine or 10 mumol/l pimozide almost completely blocked hyposmolarity-induced secretion.", "entity1": "calmodulin", "entity2": "pimozide", "span1": [86, 96], "span2": [181, 189]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8307": {"label": 2, "data": {"text": "Cellular responses to DNA damage induced by etoposide or doxorubicin include down-regulation of endogenous supervillin coincident with increases in p53.", "entity1": "p53", "entity2": "doxorubicin", "span1": [148, 151], "span2": [57, 68]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8042": {"label": 2, "data": {"text": "Finally, chronic administration of metformin in diabetic mice restored cardiac autophagy by activating JNK1-Bcl-2 pathways and dissociating Beclin1 and Bcl-2.", "entity1": "JNK1", "entity2": "metformin", "span1": [103, 107], "span2": [35, 44]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11034": {"label": 1, "data": {"text": "In vivo angiogenesis assay utilising gelfoam sponges, bexarotene reduced angiogenesis in sponges containing vascular endothelial growth factor, epidermal growth factor and basic fibroblast growth factor to various extent.", "entity1": "epidermal growth factor", "entity2": "bexarotene", "span1": [144, 167], "span2": [54, 64]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3854": {"label": 3, "data": {"text": "Glutaraldehyde crosslinked albumin nanoparticles with a size of approximately 100nm were loaded with the multikinase inhibitor 17864-L(x)-a platinum-bound sunitinib analogue-which couples the drug to methionine residues of albumin and is released in a reductive environment.", "entity1": "multikinase", "entity2": "17864", "span1": [105, 116], "span2": [127, 132]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14298": {"label": 2, "data": {"text": "In summary, activation of caspases and oxidative stress were observed after AMD/TNF cotreatment, and caspase inhibitors and a lipid-soluble free-radical scavenger attenuated AMD/TNF-induced cytotoxicity.", "entity1": "caspases", "entity2": "AMD", "span1": [26, 34], "span2": [76, 79]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2956": {"label": 0, "data": {"text": "Cocrystal structures of PDE5 catalytic (C) domain with inhibitors reveal a hydrogen bond and hydrophobic interactions with Tyr-612, hydrogen bonds with Gln-817, a hydrophobic clamp formed by Phe-820 and Val-782, and contacts with His-613, Leu-765, and Phe-786 [Sung et al.", "entity1": "PDE5 catalytic (C) domain", "entity2": "Phe", "span1": [24, 49], "span2": [252, 255]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8131": {"label": 3, "data": {"text": "Sal toxicity coincided with reduced pAkt level and its downstream effectors: pCREB, pGSK-3\u03b2, Bcl-2 and neurotrophins GDNF, BDNF suggesting repressed PI3K/Akt signaling.", "entity1": "neurotrophins", "entity2": "Sal", "span1": [103, 116], "span2": [0, 3]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13898": {"label": 3, "data": {"text": "RESULTS: Captopril directly inhibited MMP-2 activity in peritoneal effluents from patients on CAPD (IC50; 48 micromol/l), and that captopril binding to the MMP-2 active site could be formed in each complex model without molecular distortion.", "entity1": "MMP-2", "entity2": "Captopril", "span1": [38, 43], "span2": [9, 18]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6486": {"label": 4, "data": {"text": "The segments were contracted with the alpha(2)-adrenoceptor agonists brimonidine, apraclonidine, and oxymetazoline.", "entity1": "alpha(2)-adrenoceptor", "entity2": "brimonidine", "span1": [38, 59], "span2": [69, 80]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1878": {"label": 1, "data": {"text": "In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone.", "entity1": "glucocorticoid receptor", "entity2": "CDB-4124", "span1": [74, 97], "span2": [173, 181]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3318": {"label": 5, "data": {"text": "After inflammation was established mice were dosed with the H4R antagonist, JNJ 7777120, or anti-IL-13 antibody for comparison.", "entity1": "H4R", "entity2": "JNJ 7777120", "span1": [60, 63], "span2": [76, 87]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8078": {"label": 3, "data": {"text": "This study was designed to test the hypothesis that orlistat inhibits CESs with higher potency toward CES1 than CES2, a carboxylesterase with little lipase activity.", "entity1": "carboxylesterase", "entity2": "orlistat", "span1": [120, 136], "span2": [52, 60]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7693": {"label": 3, "data": {"text": "Although the D1-like receptor, by itself, had no effect on VSMC proliferation, stimulation with fenoldopam, a D1-like receptor agonist, inhibited the stimulatory effect of insulin.", "entity1": "insulin", "entity2": "fenoldopam", "span1": [172, 179], "span2": [96, 106]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5953": {"label": 5, "data": {"text": "Although numerous mechanisms of action of pimozide and thioridazine have been identified, both drugs are calmodulin antagonists at drug concentrations that inhibit breast cancer cell growth in vitro.", "entity1": "calmodulin", "entity2": "pimozide", "span1": [105, 115], "span2": [42, 50]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4270": {"label": 2, "data": {"text": "Furthermore, proteosomal inhibitor MG132 suppressed AMPK activation, GSK3\u03b2 phosphorylation, cleaved PARP and deceased AEG-1 induced by ursolic acid in HepG2 cells.", "entity1": "AMPK", "entity2": "ursolic acid", "span1": [52, 56], "span2": [135, 147]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7161": {"label": 3, "data": {"text": "Telmisartan downregulates angiotensin II type 1 receptor through activation of peroxisome proliferator-activated receptor gamma.", "entity1": "angiotensin II type 1 receptor", "entity2": "Telmisartan", "span1": [26, 56], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2468": {"label": 9, "data": {"text": "Liver choline dehydrogenase and kidney betaine-homocysteine methyltransferase expression are not affected by methionine or choline intake in growing rats.", "entity1": "betaine-homocysteine methyltransferase", "entity2": "choline", "span1": [39, 77], "span2": [123, 130]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"4651": {"label": 2, "data": {"text": "CYP1A1 and CYP1A2 mRNAs were also increased by pelargonidin in three primary human hepatocytes cultures (approximately 5% of TCDD potency) and the increase in CYP1A1 protein in HepG2 and LS174T cells was comparable to the increase in catalytic activity of CYP1A1 enzyme.", "entity1": "CYP1A1", "entity2": "TCDD", "span1": [256, 262], "span2": [125, 129]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5672": {"label": 2, "data": {"text": "Further we found stimulation of FAS-expression as a result of epigenetic DNA demethylation that was due to down-regulation of DNMT1, which was rescued by re-isoprenylation by both geranylgeranyl-pyrophosphate and farnesylpyrophosphate.", "entity1": "DNMT1", "entity2": "farnesylpyrophosphate", "span1": [126, 131], "span2": [213, 234]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4560": {"label": 3, "data": {"text": "In addition, ethanol induced degradation of DNA methyltransferases (DNMT-1, DNMT-3a, and DNMT-3b), as well as the methyl CpG-binding proteins (MeCP-2, MBD-2 and MBD-3), in MEF cells by the proteasomal pathway.", "entity1": "methyl CpG-binding proteins", "entity2": "ethanol", "span1": [114, 141], "span2": [13, 20]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3704": {"label": 2, "data": {"text": "In addition, the number and area of glutathione S-transferase placental form (GST-P) positive foci and proliferating cell nuclear antigen (PCNA) positive cell ratios in the hepatocytes were significantly increased in the male and female rats that were administered 100mg/kg MEG compared with the control animals.", "entity1": "PCNA", "entity2": "MEG", "span1": [139, 143], "span2": [274, 277]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3238": {"label": 1, "data": {"text": "A comparative autoradiography study of the relationship between the binding pattern of SERT in autoshaping new untrained vs. trained treated (METH, FLX, or both) animals was made.", "entity1": "SERT", "entity2": "FLX", "span1": [87, 91], "span2": [148, 151]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14087": {"label": 9, "data": {"text": "Lenalidomide and pomalidomide inhibited autoubiquitination of CRBN in HEK293T cells expressing thalidomide-binding competent wild-type CRBN, but not thalidomide-binding defective CRBN(YW/AA).", "entity1": "CRBN", "entity2": "pomalidomide", "span1": [179, 183], "span2": [17, 29]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"8267": {"label": 8, "data": {"text": "Methadone N-demethylation in vitro is catalyzed by hepatic cytochrome P4502B6 (CYP2B6) and CYP3A4, but clinical disposition is often attributed to CYP3A4.", "entity1": "CYP3A4", "entity2": "Methadone", "span1": [147, 153], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"4618": {"label": 2, "data": {"text": "Chronic consumption of alcohol also stimulated abrupt increases in pro-inflammatory cytokines such as nuclear factor (NF)-\u03baB, tumor necrosis factor (TNF)-\u03b1 and interleukin (IL)-1\u03b2 in liver otherwise co-administration of CNF effectively suppressed production of these cytokines dose-dependently.", "entity1": "tumor necrosis factor (TNF)-\u03b1", "entity2": "alcohol", "span1": [126, 155], "span2": [23, 30]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"9244": {"label": 8, "data": {"text": "Hence, triclosan has the ability to inhibit both the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid metabolism with similar efficacy.", "entity1": "cyclo-oxygenase", "entity2": "arachidonic acid", "span1": [53, 68], "span2": [98, 114]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2709": {"label": 2, "data": {"text": "There was also an increase in c-kit, Trio, Rho-A, Rac-3, EGFR, Notch-4, Dvl-2, Ezrin, beta catenin and mutant p53 protein expression in the parathion-treated cells.", "entity1": "Rho-A", "entity2": "parathion", "span1": [43, 48], "span2": [140, 149]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"32": {"label": 9, "data": {"text": "Other agents, such as methimazole and sodium iodide, which influence thyroid cell function, do not directly interfere with the expression of M/TPO-Ag.", "entity1": "M/TPO-Ag", "entity2": "methimazole", "span1": [141, 149], "span2": [22, 33]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"13649": {"label": 0, "data": {"text": "The binding of U46619 to the PGIS protein was demonstrated by 1D NMR titration, and the significant perturbation of the chemical shifts of protons at C-11, H2C, and H20 of U46619 were observed upon U46619 binding to the engineered PGIS in a concentration-dependent manner.", "entity1": "PGIS", "entity2": "H20", "span1": [29, 33], "span2": [165, 168]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9066": {"label": 1, "data": {"text": "In vitro binding affinities of chlorpromazine, fluphenazine, levomepromazine, perphenazine and some of their metabolites for dopamine D2 receptors, alpha 1- and alpha 2 adrenoceptors in rat brain were previously reported from our laboratories.", "entity1": "dopamine D2 receptors", "entity2": "chlorpromazine", "span1": [125, 146], "span2": [31, 45]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2333": {"label": 3, "data": {"text": "Multiple exposure to theophylline, a phosphodiesterase (PDE) inhibitor, induces acinar hypertrophy in the salivary gland.", "entity1": "phosphodiesterase", "entity2": "theophylline", "span1": [37, 54], "span2": [21, 33]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10069": {"label": 8, "data": {"text": "The transport amiloride-sensitive mechanism, that decreased the acidic intracellular pH change occurring in this medium, would correspond to Na+-H+ exchange (NHE1 isoform).", "entity1": "NHE1", "entity2": "Na+", "span1": [158, 162], "span2": [141, 144]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"13107": {"label": 1, "data": {"text": "There is a growing appreciation that the cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) signaling pathway is organized to form transduction units that function to deliver specific messages.", "entity1": "protein kinase A", "entity2": "cAMP", "span1": [79, 95], "span2": [73, 77]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"16032": {"label": 3, "data": {"text": "This effect was prevented by rapamycin, an inhibitor of the mammalian target of rapamycin complex 1 (mTORC1), or by PF470867, a selective inhibitor of the p70 ribosomal S6 kinase 1 (S6K1).", "entity1": "p70 ribosomal S6 kinase 1", "entity2": "PF470867", "span1": [155, 180], "span2": [116, 124]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5110": {"label": 2, "data": {"text": "Thus, we found that 5HHMF enhances heme oxygenase-1 (HO-1) expression via nuclear factor-erythroid 2-related factor 2 (Nrf2) activation.", "entity1": "heme oxygenase-1", "entity2": "5HHMF", "span1": [35, 51], "span2": [20, 25]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6377": {"label": 3, "data": {"text": "Thirty-week administration of UFT with or without leucovorin markedly suppressed both colorectal carcinogenesis and tumor growth, resulted in the increase of thymidylate synthase inhibition and the decrease of thymidine kinase activity in the tumor cells.", "entity1": "thymidylate synthase", "entity2": "UFT", "span1": [158, 178], "span2": [30, 33]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6825": {"label": 3, "data": {"text": "These results suggest that pitavastatin efficiently increases apoA-I in the culture medium of HepG2 cells by promoting apoA-I production through inhibition of HMG-CoA reductase and suppression of Rho activity and by protecting apoA-I from catabolism through ABCA1 induction and lipidation of apoA-I.", "entity1": "HMG-CoA reductase", "entity2": "pitavastatin", "span1": [159, 176], "span2": [27, 39]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"13064": {"label": 9, "data": {"text": "Accumulated evidence in humans and animals shows that both aspirin and H. pylori upregulate the expression of cyclooxygenase (COX)-2 both at mRNA and protein levels at the ulcer margin, but failed to influence significantly that of COX-1.", "entity1": "COX-1", "entity2": "aspirin", "span1": [232, 237], "span2": [59, 66]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13870": {"label": 6, "data": {"text": "Because these speeds are significantly faster than the responses to antagonists, these data indicate that gallamine and dimethyl-W84 are allosteric ligands and actively induce a conformation of the M(2) receptor with a reduced affinity for its agonists.", "entity1": "M(2) receptor", "entity2": "dimethyl-W84", "span1": [198, 211], "span2": [120, 132]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, 2, -1, -1, -1, 3, -1, -1, 4, 5, -1, 6, -1, -1, -1, -1, -1, -1, -1]},
+	"5380": {"label": 6, "data": {"text": "Rapamycin is a canonical allosteric inhibitor of the mTOR kinase with immunosuppressive and pro-apoptotic activities.", "entity1": "mTOR", "entity2": "Rapamycin", "span1": [53, 57], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1]},
+	"1737": {"label": 5, "data": {"text": "The alpha(1)-adrenoceptor antagonist, tamsulosin, is selective for alpha(1A)- and alpha(1D)- over alpha(1B)-adrenoceptors.", "entity1": "alpha(1A)- and alpha(1D)- over alpha(1B)-adrenoceptors", "entity2": "tamsulosin", "span1": [67, 121], "span2": [38, 48]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7718": {"label": 2, "data": {"text": "Luteinizing hormone-releasing hormone (LHRH) agonists, such as buserelin, goserelin, leuprorelin and triptorelin, stimulate the pituitary's gonadotrophin-releasing hormone (GnRH) receptor, ultimately leading to its de-sensitization and subsequent reduction of LH and testosterone levels.", "entity1": "gonadotrophin-releasing hormone (GnRH) receptor", "entity2": "buserelin", "span1": [140, 187], "span2": [63, 72]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, 3, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15035": {"label": 8, "data": {"text": "All the compounds were evaluated for their anti-tumor activity against MCF-7, A549 and B16-F10 tumor cell lines as well as cyclooxygenase-2 (COX-2)-derived prostaglandin E2 (PGE2) inhibitory activity of murine macrophage RAW 264.7 cell line.", "entity1": "cyclooxygenase-2", "entity2": "PGE2", "span1": [123, 139], "span2": [174, 178]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8184": {"label": 2, "data": {"text": "Consistent with zinc finger E-box binding homeobox 2, which was confirmed as a direct target of miR-200b in endometrial cancer cell lines, some other key factors of EMT such as Snail and N-cadherin increased, whereas E-cadherin decreased in the TAM-treated cells, contributing to TAM-induced EMT in these endometrial cancer cells.", "entity1": "Snail", "entity2": "TAM", "span1": [177, 182], "span2": [245, 248]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9813": {"label": 3, "data": {"text": "Mibefradil blocked alpha1A and alpha1E with a Kd comparable to that reported for T-type channels, but had a lower affinity (approximately 30-fold) for alpha1C.", "entity1": "T-type channels", "entity2": "Mibefradil", "span1": [81, 96], "span2": [0, 10]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6908": {"label": 8, "data": {"text": "PSMA acts as a glutamate carboxypeptidase (GCPII) on small molecule substrates, including folate, the anticancer drug methotrexate, and the neuropeptide N-acetyl-l-aspartyl-l-glutamate.", "entity1": "PSMA", "entity2": "folate", "span1": [0, 4], "span2": [90, 96]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"12254": {"label": 8, "data": {"text": "Because of their low asparagine synthetase (ASNS) expression and asparagine biosynthesis, acute lymphoblastic leukemia (ALL) cells are exquisitely sensitive to asparagine depletion.", "entity1": "asparagine synthetase", "entity2": "asparagine", "span1": [21, 42], "span2": [65, 75]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"266": {"label": 0, "data": {"text": "Cyclodiene resistance in D. melanogaster has been attributed to a mutation resulting in an Ala302-->Ser replacement in the Rdl GABA receptor subunit and in D. simulans to an homologous Ala-->Ser or Gly replacement.", "entity1": "Rdl GABA receptor", "entity2": "Gly", "span1": [123, 140], "span2": [198, 201]}, "weak_labels": [-1, 0, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14712": {"label": 3, "data": {"text": "Furthermore, insulin-stimulated T-I cell proliferation and the expression of cell cycle regulatory proteins CDK4, CCND3 and PCNA were also blocked by rapamycin.", "entity1": "cell cycle regulatory proteins", "entity2": "rapamycin", "span1": [77, 107], "span2": [150, 159]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4204": {"label": 3, "data": {"text": "Taken together, PTE is a potent inhibitor of osteosarcoma cell growth that targets the JAK2/STAT3 signaling pathway.", "entity1": "JAK2", "entity2": "PTE", "span1": [87, 91], "span2": [16, 19]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1524": {"label": 3, "data": {"text": "administration of very low doses of okadaic acid (0.001-1 pg/mouse) and cantharidin (0.001-1 ng/mouse), which inhibit PP2A, produced a dose-dependent antagonism of the antinociception induced by morphine (s.c.).", "entity1": "PP2A", "entity2": "cantharidin", "span1": [118, 122], "span2": [72, 83]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, 5, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"5150": {"label": 0, "data": {"text": "Identification of a new interaction mode between the Src homology 2 (SH2) domain of CC-terminal Src kinase (Csk) and Csk-binding protein (Cbp)/phosphoprotein associated with glycosphingolipid microdomains (PAG).", "entity1": "C-terminal Src kinase", "entity2": "C", "span1": [85, 106], "span2": [84, 85]}, "weak_labels": [-1, -1, -1, 1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8668": {"label": 2, "data": {"text": "While imatinib was unable to block cisplatin-induced DNA damage and damage response, such as the upregulation of p53, imatinib inhibited the cisplatin-induced nuclear accumulation of c-Abl/TAp73 and the subsequent downregulation of TAp63 and upregulation of Bax, thereby abrogating oocyte cell death.", "entity1": "p53", "entity2": "cisplatin", "span1": [113, 116], "span2": [35, 44]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, 2, 3, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2359": {"label": 3, "data": {"text": "Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature.", "entity1": "tyrosine kinases", "entity2": "Sorafenib", "span1": [110, 126], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"320": {"label": 0, "data": {"text": "The refolding kinetics of guanidine-denatured disulfide-intact bovine pancreatic ribonuclease A (RNase A) and its proline-42-to-alanine mutant (Pro42Ala) have been studied by monitoring tyrosine burial and 2'-cytidine monophosphate (2'CMP) inhibitor binding.", "entity1": "bovine pancreatic ribonuclease A", "entity2": "alanine", "span1": [63, 95], "span2": [128, 135]}, "weak_labels": [-1, -1, 0, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1624": {"label": 3, "data": {"text": "This led to the discovery of aliskiren, a highly potent and selective inhibitor of human renin in vitro, and in vivo; once-daily oral doses of aliskiren inhibit renin and lower blood pressure in sodium-depleted marmosets and hypertensive human patients.", "entity1": "human renin", "entity2": "aliskiren", "span1": [83, 94], "span2": [29, 38]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6301": {"label": 4, "data": {"text": "The high affinity 5-HT1B receptor agonist, 5-nonyloxytryptamine (5-NOT)-stimulated [3H]L-Cit turnover responses were concentration-(0.01 nM to 100 microM) and time-dependent.", "entity1": "5-HT1B", "entity2": "5-nonyloxytryptamine", "span1": [18, 24], "span2": [43, 63]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"13710": {"label": 3, "data": {"text": "Estimated affinities for the fast-inactivated channel state were 81 nM, 312 nM and 227 nM for 4-iodopropofol, 4-bromopropofol and 4-chloropropofol in Na(V)1.4, and 450 nM for 4-chloropropofol in Na(V)1.2.", "entity1": "Na(V)1.4", "entity2": "4-chloropropofol", "span1": [150, 158], "span2": [130, 146]}, "weak_labels": [-1, -1, -1, -1, -1, 1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4880": {"label": 2, "data": {"text": "Methylation-specific PCR and bisulfite sequencing identified methylation of this CpG ((m)CpG) island of the glut3 gene, frequency of methylation increasing 2.5-fold with a 1.6-fold increase in DNA methyl transferase 3a concentrations noted with advancing postnatal age (PN14 vs PN3).", "entity1": "DNA methyl transferase 3a", "entity2": "CpG", "span1": [193, 218], "span2": [81, 84]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"12728": {"label": 8, "data": {"text": "Acetylcholinesterase (AChE) predominates in the healthy brain, with butyrylcholinesterase (BuChE) considered to play a minor role in regulating brain acetylcholine (ACh) levels.", "entity1": "butyrylcholinesterase", "entity2": "ACh", "span1": [68, 89], "span2": [165, 168]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8597": {"label": 2, "data": {"text": "Further, both the flavonoids were also found to increase the expression of some of the prominent markers for differentiation of osteoblast like osteopontin, osterix, RunX2, osteoprotegerin and osteocalcin.", "entity1": "osteoprotegerin", "entity2": "flavonoids", "span1": [173, 188], "span2": [18, 28]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6324": {"label": 3, "data": {"text": "Caffeine inhibits the checkpoint kinase ATM.", "entity1": "ATM", "entity2": "Caffeine", "span1": [40, 43], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9072": {"label": 9, "data": {"text": "In contrast, serum alkaline phosphatase was elevated in animals dosed with 13cisRA or 4HPR but not in those dose with ROAc.", "entity1": "alkaline phosphatase", "entity2": "ROAc", "span1": [19, 39], "span2": [118, 122]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"10063": {"label": 2, "data": {"text": "Like conventional ACE inhibitors, omapatrilat causes extracellular volume reduction and vasodilatation; moreover, it increases levels of atrial and brain natriuretic peptides and bradykinin.", "entity1": "bradykinin", "entity2": "omapatrilat", "span1": [179, 189], "span2": [34, 45]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2562": {"label": 9, "data": {"text": "Neonatal quinpirole treatment produced a significant decrease in BDNF and ChAT in the frontal cortex that was unaffected by olanzapine treatment.", "entity1": "BDNF", "entity2": "olanzapine", "span1": [65, 69], "span2": [124, 134]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"5177": {"label": 3, "data": {"text": "Results of RT-PCR analysis showed decrease of p53 mRNA level and no significant difference in Bcl-2 and Bax mRNA expressions in DEX-treated rats.", "entity1": "p53", "entity2": "DEX", "span1": [46, 49], "span2": [128, 131]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14950": {"label": 1, "data": {"text": "Styrene oxide and 4-vinylphenol possessed similar affinity for CYP2E1.", "entity1": "CYP2E1", "entity2": "4-vinylphenol", "span1": [63, 69], "span2": [18, 31]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7528": {"label": 8, "data": {"text": "Brain cyclooxygenases (COX), the rate-limiting enzyme in prostaglandin synthesis, is rapidly and transiently induced by convulsions in hippocampal and cortical neurons.", "entity1": "cyclooxygenases", "entity2": "prostaglandin", "span1": [6, 21], "span2": [57, 70]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5557": {"label": 2, "data": {"text": "Treatment of cells with BCNU to inhibit glutathione reductase (GR) enhanced the CpG-induced intracellular oxidation and decreased the GSH/GSSG, with increased activation of NF-kappaB and a doubling in the CpG-induced production of IL-6 and TNF-alpha.", "entity1": "TNF-alpha", "entity2": "BCNU", "span1": [240, 249], "span2": [24, 28]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, 2, -1, -1, -1, 3, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"2757": {"label": 3, "data": {"text": "Interestingly, a Val-349 to Ile mutant was inhibited with equal potency to human COX-2 with 2,6-dichloro-, 2,6-dimethyl-, or 2-chloro-6-methyl-substituted inhibitors and, in the case of lumiracoxib, actually showed an increase in potency.", "entity1": "Val-349 to Ile", "entity2": "2,6-dimethyl", "span1": [17, 31], "span2": [107, 119]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10804": {"label": 3, "data": {"text": "COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis.", "entity1": "COX-2", "entity2": "phenylbutazone", "span1": [10, 15], "span2": [45, 59]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1814": {"label": 3, "data": {"text": "In comparison to diphenylhydantoin, the novel chloro-substituted alpha-hydroxyphenylamide compounds produced as much as a 20-fold greater tonic and frequency-dependent blockade of Na(V)1.5 channels with an IC(50) value of 14.5 microM.", "entity1": "Na(V)1.5", "entity2": "alpha-hydroxyphenylamide", "span1": [180, 188], "span2": [65, 89]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"34": {"label": 2, "data": {"text": "TSH and cAMP also increase the levels of the specific mRNA for TPO in thyroid cells from different species.", "entity1": "TPO", "entity2": "cAMP", "span1": [63, 66], "span2": [8, 12]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14032": {"label": 8, "data": {"text": "Although genetic polymorphisms in the endothelial nitric oxide synthase (eNOS) gene may impair endogenous NO formation, there is little information about how eNOS polymorphisms and haplotypes affect the responses to sildenafil.", "entity1": "endothelial nitric oxide synthase", "entity2": "NO", "span1": [38, 71], "span2": [106, 108]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8510": {"label": 1, "data": {"text": "To overcome this limitation, we de novo synthesized a conjugate that covalently combines a Gd-based MRI contrast agent, encaged with a chelating agent (DOTA), with pantoprazole, which is a widely used proton pump inhibitor that binds to proton pumps in the stomach and colon.", "entity1": "proton pumps", "entity2": "Gd", "span1": [237, 249], "span2": [91, 93]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13071": {"label": 1, "data": {"text": "Based on selective nucleoside protection, TS was found to be the primary pemetrexed target in both cell lines with GARFT inhibition requiring 20- to 30-fold higher pemetrexed concentrations.", "entity1": "TS", "entity2": "pemetrexed", "span1": [42, 44], "span2": [73, 83]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9383": {"label": 0, "data": {"text": "The amino acid sequence deduced from the nucleotide sequence of the cloned PHBP cDNA exhibited significant homology to that of hepatocyte growth factor activator (HGFA).", "entity1": "PHBP", "entity2": "nucleotide", "span1": [75, 79], "span2": [41, 51]}, "weak_labels": [0, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12796": {"label": 3, "data": {"text": "In a human whole blood assay, IC(50) values for lumiracoxib were 0.13 microM for COX-2 and 67 microM for COX-1 (COX-1/COX-2 selectivity ratio 515).", "entity1": "COX-2", "entity2": "lumiracoxib", "span1": [118, 123], "span2": [48, 59]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13850": {"label": 3, "data": {"text": "As discussed in this review, various progestogens including dydrogesterone and its 20alpha-dihydro-derivative, medrogestone, promegestone, nomegestrol acetate and norelgestromin can reduce intratissular levels of estradiol in breast cancer by blocking sulfatase and 17beta-hydroxysteroid-dehydrogenase type 1 activities.", "entity1": "17beta-hydroxysteroid-dehydrogenase type 1", "entity2": "promegestone", "span1": [266, 308], "span2": [125, 137]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10575": {"label": 2, "data": {"text": "Imiquimod (IMQ), an activator of Toll-like receptor-7 (TLR-7), induces by several routes a profound anti-viral and anti-tumor effect in vivo.", "entity1": "Toll-like receptor-7", "entity2": "IMQ", "span1": [33, 53], "span2": [11, 14]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1360": {"label": 1, "data": {"text": "A series of mazindol (2) and homomazindol (3) analogues with a variety of electron-donating and electron-withdrawing groups in the pendant aryl group and the benzo ring C, as well as H, methoxy, and alkyl groups replacing the hydroxyl group were synthesized, and their binding affinities at the dopamine transporter (DAT) on rat or guinea pig striatal membranes were determined.", "entity1": "dopamine transporter", "entity2": "homomazindol", "span1": [295, 315], "span2": [29, 41]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"16051": {"label": 3, "data": {"text": "Simvastatin and lovastatin metabolized through CYP3A have the highest potency for drug-drug interaction with potent CYP3A inhibitors such as ritonavir- or cobicistat-boosted HIV-PI or the hepatitis C virus (HCV) PI, telaprevir or boceprevir, and therefore their coadministration is contraindicated.", "entity1": "CYP3A", "entity2": "boceprevir", "span1": [116, 121], "span2": [230, 240]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3150": {"label": 2, "data": {"text": "Amitriptyline, but not any other tricyclic or selective serotonin reuptake inhibitor antidepressants, promotes TrkA autophosphorylation in primary neurons and induces neurite outgrowth in PC12 cells.", "entity1": "TrkA", "entity2": "Amitriptyline", "span1": [111, 115], "span2": [0, 13]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"13896": {"label": 3, "data": {"text": "We determined whether an angiotensin-converting enzyme (ACE) inhibitor, captopril, inhibits MMP-2 activity in peritoneal effluents from patients on CAPD, and simulated molecular models of the MMP-2-captopril complex.", "entity1": "ACE", "entity2": "captopril", "span1": [56, 59], "span2": [72, 81]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1]},
+	"12887": {"label": 3, "data": {"text": "Sorafenib (BAY 43-9006) is a small-molecule inhibitor that has been shown to target members of multiple classes of tyrosine kinases that are known to be involved in tumor cell proliferation and tumor angiogenesis.", "entity1": "tyrosine kinases", "entity2": "Sorafenib", "span1": [115, 131], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15744": {"label": 1, "data": {"text": "CO scavenging blocked the suppression of quercetin only on CYP2E1 activity.", "entity1": "CYP2E1", "entity2": "quercetin", "span1": [59, 65], "span2": [41, 50]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5920": {"label": 1, "data": {"text": "Analysis of this relationship shows that estramustine phosphate and tubulin compete for common MAP2 sites, that MAP2 can bind 5-6 moles.mole-1 estramustine phosphate, and that the Kd of these sites is congruent to 20 microM estramustine phosphate.", "entity1": "MAP2", "entity2": "estramustine phosphate", "span1": [95, 99], "span2": [41, 63]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8748": {"label": 8, "data": {"text": "Using recombinant UGT2B10, we found that it catalyzes the N-glucuronidation of amitriptyline, imipramine, ketotifen, pizotifen, olanzapine, diphenhydramine, tamoxifen, ketoconazole and midazolam.", "entity1": "UGT2B10", "entity2": "midazolam", "span1": [18, 25], "span2": [185, 194]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"8202": {"label": 3, "data": {"text": "Synthesis and dual biological effects of hydroxycinnamoyl phenylalanyl/prolyl hydroxamic acid derivatives as tyrosinase inhibitor and antioxidant.", "entity1": "tyrosinase", "entity2": "hydroxycinnamoyl phenylalanyl", "span1": [109, 119], "span2": [41, 70]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15318": {"label": 1, "data": {"text": "Racemic IKM-159 was crystallized with the ligand-binding domain of GluA2, and the structure revealed a complex containing (2R)-IKM-159 at the glutamate binding site.", "entity1": "GluA2", "entity2": "(2R)-IKM-159", "span1": [67, 72], "span2": [122, 134]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12087": {"label": 3, "data": {"text": "), MAO-B by (-)deprenyl (1 mg/kg i.p.", "entity1": "MAO-B", "entity2": "(-)deprenyl", "span1": [3, 8], "span2": [12, 23]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"257": {"label": 1, "data": {"text": "An experimental strategy based on solution viscosity perturbation allowed us to study the energetics of amide-substrates, p-aminobenzamidine (p-ABZ) and proflavin binding to the catalytic site of two proteolyzed forms of alpha-thrombin, i.e.", "entity1": "alpha-thrombin", "entity2": "p-ABZ", "span1": [221, 235], "span2": [142, 147]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"4767": {"label": 3, "data": {"text": "Furthermore, BRN-250 inhibited the VEGF-induced phosphorylation and intracellular tyrosine kinase activity of VEGF receptor 2 (VEGFR2) and the activation of its downstream AKT pathway.", "entity1": "VEGFR2", "entity2": "BRN-250", "span1": [127, 133], "span2": [13, 20]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9241": {"label": 3, "data": {"text": "Hence, triclosan has the ability to inhibit both the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid metabolism with similar efficacy.", "entity1": "lipoxygenase", "entity2": "triclosan", "span1": [73, 85], "span2": [7, 16]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4586": {"label": 0, "data": {"text": "Cellular protein labeling occurs only upon activation of two different promoters that drive expression of the N- and C-terminal fragments of the bisected MetRS.", "entity1": "MetRS", "entity2": "C", "span1": [154, 159], "span2": [117, 118]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13320": {"label": 3, "data": {"text": "All three salicylates inhibited the diabetes-induced translocation of p50 (a subunit of NF-kappaB) into nuclei of retinal vascular endothelial cells of the isolated retinal vasculature, as well as of p50 and p65 into nuclei of cells in the ganglion cell layer and inner nuclear layer on whole-retinal sections.", "entity1": "p50", "entity2": "salicylates", "span1": [200, 203], "span2": [10, 21]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13720": {"label": 1, "data": {"text": "RTX treatment also induced foci of RAD51, gamma-H2AX, phospho-Chk1, and phospho-NBS1, although the extent of co-localization with RPA2 foci varied.", "entity1": "RPA2", "entity2": "RTX", "span1": [130, 134], "span2": [0, 3]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6328": {"label": 3, "data": {"text": "In preliminary studies, in vitro incubation of rat cerebral cortex with RTI-76 produced a wash and temperature resistant inhibition of SERT binding densities (Bmax).", "entity1": "SERT", "entity2": "RTI-76", "span1": [135, 139], "span2": [72, 78]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"10519": {"label": 3, "data": {"text": "To gauge the potential clinical utility of targeting both EGFR and HER2 to control growth and radiosensitize human breast cancers, we examined the effect of a dual EGFR/HER2 inhibitor, GW572016, on the proliferation and radiation response of either EGFR- or HER2-overexpressing human breast cancer cell lines.", "entity1": "EGFR", "entity2": "GW572016", "span1": [164, 168], "span2": [185, 193]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4945": {"label": 3, "data": {"text": "Furthermore, a decreased CD11c(+) macrophage infiltration in colons and inactivation of caspase-1 in peritoneal macrophages were detected in Fc11a-2-treated mice.", "entity1": "caspase-1", "entity2": "Fc11a", "span1": [88, 97], "span2": [141, 146]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10974": {"label": 3, "data": {"text": "mRNA levels for RAR-alpha, RAR-beta and RAR-gamma, the nuclear receptors for retinoic acid, decreased during activation of freshly isolated HSC even with retinoid supplementation.", "entity1": "nuclear receptors", "entity2": "retinoid", "span1": [55, 72], "span2": [154, 162]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11173": {"label": 1, "data": {"text": "Lithium's effects on GluR3 desensitization are distinct from the effects of aniracetam on desensitization.", "entity1": "GluR3", "entity2": "aniracetam", "span1": [21, 26], "span2": [76, 86]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"602": {"label": 3, "data": {"text": "Cyclopentenone prostaglandins were potent inhibitors of iNOS induction and were more effective than their precursors, prostaglandins E2 and D2.", "entity1": "iNOS", "entity2": "Cyclopentenone prostaglandins", "span1": [56, 60], "span2": [0, 29]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10310": {"label": 1, "data": {"text": "Each dimeric analog showed higher affinities for alpha2A- and alpha2C-adrenoceptor versus the alpha2B-adrenoceptor; and yohimbine dimers with spacers of n = 2, 3, 4, 18, and 24 exhibited selectivity for the alpha2C-adrenoceptor.", "entity1": "alpha2C-adrenoceptor", "entity2": "yohimbine", "span1": [207, 227], "span2": [120, 129]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9508": {"label": 1, "data": {"text": "Saturation and competition studies in the presence or absence of the histamine H1 receptor antagonist, levocabastine, revealed that [3H]SR 142948A bound with similar affinities to both the levocabastine-insensitive neurotensin NT1 receptors (20% of the total binding population) and the recently cloned levocabastine-sensitive neurotensin NT2 receptors (80% of the receptors) (Kd = 6.8 and 4.8 nM, respectively).", "entity1": "neurotensin NT2 receptors", "entity2": "[3H]SR 142948A", "span1": [327, 352], "span2": [132, 146]}, "weak_labels": [-1, -1, -1, 1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3252": {"label": 1, "data": {"text": "The other endogenous steroids, androstenedione (ANE) and dihydrotestosterone (DHT), had considerably lower hAR transport rates.", "entity1": "hAR", "entity2": "ANE", "span1": [107, 110], "span2": [48, 51]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"12723": {"label": 8, "data": {"text": "Acetylcholinesterase (AChE) predominates in the healthy brain, with butyrylcholinesterase (BuChE) considered to play a minor role in regulating brain acetylcholine (ACh) levels.", "entity1": "AChE", "entity2": "acetylcholine", "span1": [22, 26], "span2": [150, 163]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8809": {"label": 1, "data": {"text": "The Ca2+ sensor STIM1 is crucial for activation of store-operated Ca2+ entry (SOCE) through TRPC and Orai channels.", "entity1": "Orai channels", "entity2": "Ca2+", "span1": [101, 114], "span2": [4, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5078": {"label": 2, "data": {"text": "In addition to CYP2B6, anisomycin co-treatment potentiated an increase in CYP2A7 and CYP2C9 mRNAs but not CYP3A4 or UDP-glucuronosyltransferase 1A1 mRNAs.", "entity1": "CYP2B6", "entity2": "anisomycin", "span1": [15, 21], "span2": [23, 33]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"10791": {"label": 2, "data": {"text": "Simvastatin, an HMG-CoA reductase inhibitor with mild inhibition of LFA-1, induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma in human peripheral blood mononuclear cells (PBMC).", "entity1": "interferon (IFN)-gamma", "entity2": "Simvastatin", "span1": [160, 182], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"2363": {"label": 3, "data": {"text": "Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature.", "entity1": "MEK", "entity2": "Sorafenib", "span1": [75, 78], "span2": [0, 9]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11350": {"label": 3, "data": {"text": "Phenytoin (diphenylhydantoin, DPH) is an established sodium channel blocker and is a useful anticonvulsant and class 1b antiarrhythmic, and has been effectively used in the treatment of neuropathic pain.", "entity1": "sodium channel", "entity2": "DPH", "span1": [53, 67], "span2": [30, 33]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"168": {"label": 3, "data": {"text": "Effects of some mono- and bisquaternary ammonium compounds on the reactivatability of soman-inhibited human acetylcholinesterase in vitro.", "entity1": "human acetylcholinesterase", "entity2": "soman", "span1": [102, 128], "span2": [86, 91]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11976": {"label": 0, "data": {"text": "Saccharomyces cerevisiae \u03c455, a subunit of the RNA polymerase III-specific general transcription factor TFIIIC, comprises an N-terminal histidine phosphatase domain (\u03c455-HPD) whose catalytic activity and cellular function is poorly understood.", "entity1": "Saccharomyces cerevisiae \u03c455", "entity2": "N", "span1": [0, 28], "span2": [125, 126]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7028": {"label": 1, "data": {"text": "Further, cholesterol metabolites, predominantly the oxysterols, the natural ligands for liver X receptor (LXR), induced these genes via upregulation of sterol regulatory element binding protein-1c (SREBP-1c) that bound to the regulatory regions of these genes.", "entity1": "liver X receptor", "entity2": "cholesterol", "span1": [88, 104], "span2": [9, 20]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1247": {"label": 3, "data": {"text": "The selective PDE 4 inhibitors, and to a certain extent the PDE3 inhibitors amrinone and milrinone, reduced the GM-CSF release in a concentration dependent manner.", "entity1": "PDE3", "entity2": "milrinone", "span1": [60, 64], "span2": [89, 98]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3679": {"label": 3, "data": {"text": "Taken together, these findings indicate that the inhibition of melanogenesis by artemisinic acid occurs through reduced expression of the HMG CoA reductase gene, which is mediated by C/EBP \u03b1 inhibition and suggest that artemisinic acid may be useful as a hyperpigmentation inhibitor.", "entity1": "C/EBP \u03b1", "entity2": "artemisinic acid", "span1": [183, 190], "span2": [80, 96]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11711": {"label": 2, "data": {"text": "Based on these studies, the frequency of spontaneous tail contractions at 26 hpf - a developmental stage with minimal AChE expression and activity - was significantly higher following exposure to paraoxon concentrations as low as 31.2 nM.", "entity1": "AChE", "entity2": "paraoxon", "span1": [118, 122], "span2": [196, 204]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13178": {"label": 2, "data": {"text": "Progestin induction of the cyclin D1 gene, which lacks a progesterone response element, was dependent on PR activation of the Src/MAPK pathway, whereas induction of the Sgk (serum and glucocorticoid regulated kinase) gene that contains a functional progesterone response element was unaffected by mutations that interfere with PR activation of Src.", "entity1": "MAPK", "entity2": "Progestin", "span1": [130, 134], "span2": [0, 9]}, "weak_labels": [-1, -1, 0, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5599": {"label": 1, "data": {"text": "The patients were divided into two groups according to the 5HT-2A affinity of the individual medications (high 5HT-2A affinity--clozapine, olanzapine, risperidone vs. low 5HT-2A affinity--quetiapine, amisulpride).", "entity1": "5HT-2A", "entity2": "risperidone", "span1": [171, 177], "span2": [151, 162]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14147": {"label": 2, "data": {"text": "When combined, mianserin antagonized the effects of the full kappa-opioid receptor agonists in [(35)S]GTPgammaS assays and reduced the stimulation of p38 MAPK and ERK1/2 phosphorylation by dynorphin A.", "entity1": "p38", "entity2": "dynorphin A", "span1": [150, 153], "span2": [189, 200]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, 3, -1, -1, 4, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15573": {"label": 0, "data": {"text": "The gp41 subunit contains several functional domains: the N-terminal heptad repeat (NHR) domains fold a triple stranded coiled-coil forming a meta-stable prefusion intermediate.", "entity1": "gp41", "entity2": "N", "span1": [4, 8], "span2": [58, 59]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14788": {"label": 1, "data": {"text": "Treatment with TSA and the Nrf2-ARE activator resulted in increased inhibition of the TGF-\u03b2-induced myofibroblast differentiation as compared with treatment with DPI or NAC.", "entity1": "TGF-\u03b2", "entity2": "NAC", "span1": [86, 91], "span2": [169, 172]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14614": {"label": 8, "data": {"text": "Wild-type enzymes and variants of CDA (Lys27Gln and Ala70Thr) and DCK (Ile24Val, Ala119Gly, and Pro122Ser) were expressed in and purified from Escherichia coli, and enzyme kinetic parameters were estimated for cytarabine (Ara-C), dFdC, and its metabolite 2',2'-difluorodeoxyuridine (dFdU) as substrates.", "entity1": "Pro122Ser", "entity2": "dFdC", "span1": [96, 105], "span2": [230, 234]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"11552": {"label": 1, "data": {"text": "Occupancy of dopamine D(1), D (2) and serotonin (2A) receptors in schizophrenic patients treated with flupentixol in comparison with risperidone and haloperidol.", "entity1": "serotonin (2A) receptors", "entity2": "risperidone", "span1": [38, 62], "span2": [133, 144]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15143": {"label": 9, "data": {"text": "However, there were detectable concentrations of Lhcgr, Cyp11a1 and Cyp17a1 mRNAs but undetectable concentrations of Insl3, Hsd17b3 and Hsd11b1 in the DEHP-treated testes, indicating that these 3\u03b2-HSD(pos) cells were newly formed progenitor Leydig cells.", "entity1": "Hsd17b3", "entity2": "DEHP", "span1": [124, 131], "span2": [151, 155]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9773": {"label": 5, "data": {"text": "Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors.", "entity1": "(AR)s", "entity2": "fluparoxan", "span1": [103, 108], "span2": [59, 69]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8312": {"label": 3, "data": {"text": "Novel acylethanolamide derivatives that modulate body weight through enhancement of hypothalamic pro-opiomelanocortin (POMC) and/or decreased neuropeptide Y (NPY).", "entity1": "neuropeptide Y", "entity2": "acylethanolamide", "span1": [142, 156], "span2": [6, 22]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13051": {"label": 4, "data": {"text": "CONTEXT: Ramelteon is a novel MT1 and MT2 melatonin receptor selective agonist recently approved for insomnia treatment.", "entity1": "MT1", "entity2": "Ramelteon", "span1": [30, 33], "span2": [9, 18]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9858": {"label": 6, "data": {"text": "Aspirin and sodium salicylate inhibit endothelin ETA receptors by an allosteric type of mechanism.", "entity1": "ETA receptors", "entity2": "sodium salicylate", "span1": [49, 62], "span2": [12, 29]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1]},
+	"6934": {"label": 8, "data": {"text": "When the growth condition was shifted from aerobic to anaerobic, the increased level of succinate in SDH1 disruptants was no longer observed, whereas the decreased level of succinate in the KGD1 diruptant was still observed.", "entity1": "SDH1", "entity2": "succinate", "span1": [101, 105], "span2": [88, 97]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1020": {"label": 1, "data": {"text": "In COS cells transfected with alpha(1b) adrenoceptor cDNA and in DDT(1) MF-2 cells which express native alpha(1B) adrenoceptors, [(3)H]-prazosin was displaced by unlabelled prazosin in a normal equilibrium process, with no prazosin paradox in concentrations up to 10(-6) M. In DDT(1) MF-2 cells, [(3)H]-prazosin was displaced likewise by a series of alpha(1) adrenergic agonists, none of which increased the binding of [(3)H]-prazosin.", "entity1": "alpha(1)", "entity2": "[(3)H]-prazosin", "span1": [350, 358], "span2": [296, 311]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11180": {"label": 3, "data": {"text": "To investigate the possibility that felbamate's favorable toxicity profile could be related to NMDA receptor subtype selectivity, we examined the specificity of felbamate block of recombinant NMDA receptors composed of the NR1a subunit and various NR2 subunits.", "entity1": "NMDA receptors", "entity2": "felbamate", "span1": [192, 206], "span2": [161, 170]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2015": {"label": 3, "data": {"text": "Pranlukast, a leukotriene receptor antagonist, inhibits interleukin-5 production via a mechanism distinct from leukotriene receptor antagonism.", "entity1": "interleukin-5", "entity2": "Pranlukast", "span1": [56, 69], "span2": [0, 10]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, 5, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"6534": {"label": 3, "data": {"text": "As a prodrug leflunomide is completely converted to its active metabolite A 77 1726 (M1) which blocks the dihydroorotate dehydrogenase, a key enzyme of the pyrimidine de novo synthesis.", "entity1": "dihydroorotate dehydrogenase", "entity2": "A 77 1726", "span1": [106, 134], "span2": [74, 83]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1]},
+	"13157": {"label": 2, "data": {"text": "We have previously demonstrated that phosphorylation of Fas-associated death domain-containing protein (FADD) at 194 serine through c-jun NH2-terminal kinase (JNK) activation sensitizes breast cancer cells to chemotherapy through accelerating cell cycle arrest at G2/M, and that Bcl-2 phosphorylation downstream of JNK/FADD plays an important role in cell growth suppression by paclitaxel.", "entity1": "c-jun NH2-terminal kinase", "entity2": "paclitaxel", "span1": [132, 157], "span2": [378, 388]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7633": {"label": 9, "data": {"text": "Triphosphate nucleotides (ATP, GTP, and UTP) rapidly and reversibly inhibited Panx1 currents via mechanism(s) independent of purine receptors.", "entity1": "purine receptors", "entity2": "Triphosphate nucleotides", "span1": [125, 141], "span2": [0, 24]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2465": {"label": 0, "data": {"text": "The updated bovine type II GnRH receptor gene sequence revealed inactivation by frame shifts, premature stop codons, and nucleotide changes specifying nonconservative replacement of amino acid residues, similar to inactivation of sheep type II GnRH receptor.", "entity1": "bovine type II GnRH receptor", "entity2": "amino acid", "span1": [12, 40], "span2": [182, 192]}, "weak_labels": [0, 0, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7835": {"label": 2, "data": {"text": "Nevertheless, low L-BMAA concentrations (\u2265 0.1mM, 48 h) increased protein ubiquitination, 20S proteasomal and caspase 12 activity, expression of the endoplasmic reticulum (ER) stress marker CHOP, and enhanced phosphorylation of elf2\u03b1 in SH-SY5Y cells.", "entity1": "CHOP", "entity2": "L-BMAA", "span1": [190, 194], "span2": [18, 24]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14472": {"label": 3, "data": {"text": "Blood pressure was increased in rats exposed to IH, and treatment with the PDK-1 inhibitor OSU-03012 [2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl}-acetamide] (33 mg/day) lowered blood pressure in IH but not sham group rats.", "entity1": "PDK-1", "entity2": "2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl}-acetamide", "span1": [75, 80], "span2": [102, 190]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"4224": {"label": 3, "data": {"text": "The results showed that (1) 15mg/kg body weight PhIP induced obvious histopathological changes in gastric mucosa; (2) PhIP (10 and/or 15mg/kg) significantly decreased superoxide dismutase (SOD) and glutathioneperoxidase (GPx) activities, while increased catalase (CAT) activity compared with the control.", "entity1": "superoxide dismutase", "entity2": "PhIP", "span1": [167, 187], "span2": [118, 122]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9062": {"label": 1, "data": {"text": "7-Hydroxy levomepromazine, 3-hydroxy levomepromazine and 7-hydroxy fluphenazine had only 10% of the potency of the parent drug in histamine H1 receptor binding, while the 7-hydroxy-metabolites of chlorpromazine and perphenazine had about 75% of the potency of the parent drug in this binding system.", "entity1": "histamine H1 receptor", "entity2": "perphenazine", "span1": [130, 151], "span2": [215, 227]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11496": {"label": 3, "data": {"text": "RESULTS: Ketorolac was six times more active against COX-1 (IC(50) = 0.02 microM) than COX-2 (IC(50) = 0.12 microM) while bromfenac was approximately 32 times more active against COX-2 (IC(50) = 0.0066 microM) than COX-1 (IC(50) = 0.210 microM).", "entity1": "COX-1", "entity2": "Ketorolac", "span1": [215, 220], "span2": [9, 18]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14992": {"label": 9, "data": {"text": "In monocytes, both EPA and DHA increased interleukin (IL)-10 without affecting tumor necrosis factor (TNF)-\u03b1 and IL-6.", "entity1": "tumor necrosis factor (TNF)-\u03b1", "entity2": "EPA", "span1": [79, 108], "span2": [19, 22]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"293": {"label": 3, "data": {"text": "In catalytic properties, mouse CA V is closest to CA I; however, in inhibition by acetazolamide, ethoxzolamide, and cyanate, CA V is very similar to CA II.", "entity1": "CA V", "entity2": "acetazolamide", "span1": [125, 129], "span2": [82, 95]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11058": {"label": 3, "data": {"text": "Esmolol, a unique cardioselective beta 1-adrenergic receptor blocker with a half-life of 9 minutes, can enable some patients with relative contraindications to beta blockers to nevertheless benefit from early beta-blocking therapy.", "entity1": "beta 1-adrenergic receptor", "entity2": "Esmolol", "span1": [34, 60], "span2": [0, 7]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7992": {"label": 2, "data": {"text": "Furthermore, U0126 (an ERK1/2 inhibitor) significantly enhanced the ISO-induced the Bax/Bcl-2 ratio, the release of cytochrome c to the cytosol fraction, and the levels of cleaved caspase-3.", "entity1": "Bcl-2", "entity2": "U0126", "span1": [88, 93], "span2": [13, 18]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5787": {"label": 9, "data": {"text": "A cDNA encoding the complete amino acid sequence of aminoacylase 1 (N-acylamino acid aminohydrolase, ACY-1) [EC 3.5.1.14], a dimeric metalloprotein having two Zn2+ in the molecule, which catalyzes the deacylation of N-acylated L-amino acids except L-aspartic acid, has been isolated from porcine kidney lambda gt10 cDNA library and sequenced.", "entity1": "metalloprotein", "entity2": "L-aspartic acid", "span1": [133, 147], "span2": [248, 263]}, "weak_labels": [0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"12384": {"label": 0, "data": {"text": "Similarly, mature BMP-2 was also cleaved to a truncated peptide within its N-terminal region (Arg(289)\u2193Lys(290)).", "entity1": "BMP-2", "entity2": "Lys", "span1": [18, 23], "span2": [103, 106]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"776": {"label": 3, "data": {"text": "Flecainide block of Na(+) current (I(Na)) was investigated in wild-type (WT) or the long QT syndrome 3 (LQT3) sodium channel alpha subunit mutation with three amino acids deleted (DeltaKPQ) stably transfected into human embryonic kidney 293 cells using whole-cell, patch-clamp recordings.", "entity1": "long QT syndrome 3 (LQT3) sodium channel alpha", "entity2": "Flecainide", "span1": [84, 130], "span2": [0, 10]}, "weak_labels": [0, -1, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15112": {"label": 2, "data": {"text": "Interestingly, GPx1a was the most sensitive to selenium availability in non stressful conditions, whereas GPx1b1 and GPx1b2 were highly induced by exposure to selenium levels that had some toxic effects on the cells.", "entity1": "GPx1b1", "entity2": "selenium", "span1": [106, 112], "span2": [159, 167]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8141": {"label": 3, "data": {"text": "Isoproterenol induced myocardial infarcted rats showed a significant increase in the levels of cardiac diagnostic markers, heart mitochondrial lipid peroxidation, calcium, and a significant decrease in the activities/levels of heart mitochondrial glutathione peroxidase, glutathione reductase, reduced glutathione, isocitrate, succinate, malate, \u03b1-ketoglutarate and NADH-dehydrogenases, cytochrome-C-oxidase and adenosine triphosphate.", "entity1": "glutathione peroxidase", "entity2": "Isoproterenol", "span1": [247, 269], "span2": [0, 13]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, 3, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13661": {"label": 1, "data": {"text": "High-resolution NMR spectroscopy was used to determine the docking of a substrate (prostaglandin H2) mimic (U46619) to the engineered prostacyclin (PGI2) synthase (PGIS) in solution.", "entity1": "PGIS", "entity2": "U46619", "span1": [164, 168], "span2": [108, 114]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"13689": {"label": 2, "data": {"text": "Two imidazoquinoline molecules, imiquimod and gardiquimod, markedly activated both porcine TLR7 and TLR8 whereas only human TLR7, but not TLR8, was activated by the ligands.", "entity1": "porcine TLR7", "entity2": "imidazoquinoline", "span1": [83, 95], "span2": [4, 20]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"11284": {"label": 8, "data": {"text": "One major route involves the tetrahydrofolate (THF)-dependent activities of the glycine decarboxylase complex (GDC, EC 2.1.1.10) and serine hydroxymethyltransferase (SHMT, EC 2.1.2.1) with glycine (Gly) as one-carbon (1-C) source.", "entity1": "SHMT", "entity2": "Gly", "span1": [166, 170], "span2": [198, 201]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2218": {"label": 4, "data": {"text": "Two beta(2)-agonists, formoterol and salmeterol, are approved for treating asthma and have an extended duration of action and increased safety, associated with greater beta(2)-adrenoceptor selectivity.", "entity1": "beta(2)-adrenoceptor", "entity2": "salmeterol", "span1": [168, 188], "span2": [37, 47]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2184": {"label": 0, "data": {"text": "Co-C bond activation in methylmalonyl-CoA mutase by stabilization of the post-homolysis product Co2+ cobalamin.", "entity1": "methylmalonyl-CoA mutase", "entity2": "Co-C", "span1": [24, 48], "span2": [0, 4]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"10396": {"label": 1, "data": {"text": "Defective processing of the transforming growth factor-beta1 in azoxymethane-induced mouse colon tumors.", "entity1": "transforming growth factor-beta1", "entity2": "azoxymethane", "span1": [28, 60], "span2": [64, 76]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4799": {"label": 1, "data": {"text": "The neurotrophic factors pleiotrophin (PTN) and midkine (MK) have been shown to modulate amphetamine-induced neurotoxicity.", "entity1": "PTN", "entity2": "amphetamine", "span1": [39, 42], "span2": [89, 100]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2945": {"label": 1, "data": {"text": "Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil.", "entity1": "phosphodiesterase-5", "entity2": "vardenafil", "span1": [34, 53], "span2": [131, 141]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9851": {"label": 1, "data": {"text": "Salicylates do not promote dissociation of (125)I-ET-1 ETB receptor complexes.", "entity1": "ETB receptor", "entity2": "(125)I", "span1": [55, 67], "span2": [43, 49]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"2134": {"label": 9, "data": {"text": "Although incubating HASMCs for 48h with thiazolidinediones had no effect on ENT1 mRNA and protein levels, troglitazone acutely inhibited [3H]adenosine uptake and [3H]NBMPR binding of HASMCs with IC50 values of 2.35+/-0.35 and 3.99+/-0.57microM, respectively.", "entity1": "ENT1", "entity2": "thiazolidinediones", "span1": [76, 80], "span2": [40, 58]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12109": {"label": 3, "data": {"text": "HERG/IKr channels are a prime target for the pharmacological management of arrhythmias and are selectively blocked by class III antiarrhythmic methanesulfonanilide drugs, such as dofetilide, E4031, and MK-499, at submicromolar concentrations.", "entity1": "HERG", "entity2": "methanesulfonanilide", "span1": [0, 4], "span2": [143, 163]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5818": {"label": 9, "data": {"text": "Loperamide has no significant effect on insulin-hypoglycemia-induced ACTH and cortisol levels and, therefore, no effect on stress-induced elevation of cortisol levels.", "entity1": "ACTH", "entity2": "Loperamide", "span1": [69, 73], "span2": [0, 10]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14206": {"label": 1, "data": {"text": "The structurally diverse opioids codeine and eseroline, like galantamine, are also nAChR-APL that have greatly diminished affinity for AChE, representing potential lead compounds for selective nAChR-APL development.", "entity1": "AChE", "entity2": "eseroline", "span1": [135, 139], "span2": [45, 54]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8509": {"label": 0, "data": {"text": "In addition, putative osteogenic actions of PTHrP might be ascribed not only to its N-terminal domain but also to its PTH-unrelated C-terminal region.", "entity1": "PTH", "entity2": "C", "span1": [118, 121], "span2": [132, 133]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"9439": {"label": 3, "data": {"text": "These observations show substrate- and enzyme-specific PTP inhibition by alendronate and support the possibility that a certain PTP(s) may be the molecular target for alendronate action.", "entity1": "PTP", "entity2": "alendronate", "span1": [55, 58], "span2": [73, 84]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"4322": {"label": 3, "data": {"text": "Pinosylvin inhibited the proliferation of HCT 116 cells by arresting transition of cell cycle from G1 to S phase along with the downregulation of cyclin D1, cyclin E, cyclin A, cyclin dependent kinase 2 (CDK2), CDK4, c-Myc, and retinoblastoma protein (pRb), and the upregulation of p21(WAF1/CIP1) and p53.", "entity1": "cyclin D1", "entity2": "Pinosylvin", "span1": [146, 155], "span2": [0, 10]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 2, 3, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1015": {"label": 1, "data": {"text": "Peptidergic neurones accumulate amines via an unusual uptake process, designated Transport-P. [(3)H]-prazosin binds to alpha(1) adrenoceptors on these cells and is displaceable by unlabelled prazosin in concentrations up to 10(-7) M. However, at greater concentrations of prazosin, there is a paradoxical accumulation of [(3)H]-prazosin which we have attributed to Transport-P. Uptake of prazosin via Transport-P is detectable at 10(-10) M prazosin concentration, is linear up to 10(-7) M and at greater concentrations becomes non-linear.", "entity1": "alpha(1) adrenoceptors", "entity2": "[(3)H]-prazosin", "span1": [119, 141], "span2": [94, 109]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"7861": {"label": 3, "data": {"text": "The potentiation of heteromeric KARs by mGlu1 activation was attenuated by GDP\u03b2S, blocked by an inhibitor of phospholipase C or the calcium chelator 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA), prolonged by the phosphatase inhibitor okadaic acid, but unaffected by the tyrosine kinase inhibitor lavendustin A.", "entity1": "mGlu1", "entity2": "okadaic acid", "span1": [40, 45], "span2": [254, 266]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14233": {"label": 1, "data": {"text": "The residence time of a stoichiometric bioscavenger, human butyrylcholinesterase (huBuChE), in the plasma more closely matches that of VX than do the residence times of conventional therapy drugs (oxime, anti-muscarinic, anticonvulsant).", "entity1": "human butyrylcholinesterase", "entity2": "oxime", "span1": [53, 80], "span2": [197, 202]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13242": {"label": 3, "data": {"text": "Furthermore, MG132 prevented glutamate-stimulated reduction in surface amount of GluR2, and knockdown of GRIP1 by RNAi against GRIP1 reduced surface GluR2 in neurons.", "entity1": "GluR2", "entity2": "glutamate", "span1": [81, 86], "span2": [29, 38]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10137": {"label": 3, "data": {"text": "Non-steroidal anti-inflammatory drugs (NSAIDs) are competitive inhibitors of cyclooxygenase (COX), the enzyme that mediates biosynthesis of prostaglandins and thromboxanes from arachidonic acid.", "entity1": "cyclooxygenase", "entity2": "steroidal", "span1": [77, 91], "span2": [4, 13]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11788": {"label": 1, "data": {"text": "The acyl esters could be correlated with expression of alcohol acyl-transferase EEB1 and the acyl esterase IAH1.", "entity1": "acyl esterase IAH1", "entity2": "acyl esters", "span1": [93, 111], "span2": [4, 15]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10444": {"label": 7, "data": {"text": "SDH (L-serine dehydratase, EC 4.3.1.17) catalyzes the pyridoxal 5'-phosphate (PLP)-dependent dehydration of L-serine to yield pyruvate and ammonia.", "entity1": "SDH", "entity2": "PLP", "span1": [0, 3], "span2": [78, 81]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"4076": {"label": 2, "data": {"text": "Pretreatment of human breast carcinoma MCF-7 cells for 24 h with the groundnut extract and soybean isoflavone increased gene expression of heme oxygenase-1 (HO-1), a major antioxidative stress enzyme.", "entity1": "heme oxygenase-1", "entity2": "isoflavone", "span1": [139, 155], "span2": [99, 109]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1172": {"label": 2, "data": {"text": "Mitiglinide (KAD-1229), a new anti-diabetic drug, is thought to stimulate insulin secretion by closing the ATP-sensitive K+ (K(ATP)) channels in pancreatic beta-cells.", "entity1": "insulin", "entity2": "Mitiglinide", "span1": [74, 81], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14187": {"label": 3, "data": {"text": "CBDP irreversibly inhibits butyrylcholinesterase (BChE) in human plasma by forming adducts on the active site serine (Ser-198).", "entity1": "butyrylcholinesterase", "entity2": "CBDP", "span1": [27, 48], "span2": [0, 4]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13141": {"label": 2, "data": {"text": "This mRNA level elevation was not prevented by pretreatment with actinomycin D. When the PTB-binding site in insulin 1 mRNA was incubated with the islet cytosolic fraction, the RNA-protein complex level was increased in the cytosolic fraction obtained from GalN-treated rats compared to the level in control rats.", "entity1": "PTB-binding site", "entity2": "GalN", "span1": [89, 105], "span2": [257, 261]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"15474": {"label": 9, "data": {"text": "Glutathione-S-transferase, a phase II enzyme, was inhibited by both arsenic and nicotine but no such inhibition was noted in arsenic-treated animals pre-exposed to nicotine.", "entity1": "Glutathione-S-transferase", "entity2": "nicotine", "span1": [0, 25], "span2": [164, 172]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"712": {"label": 3, "data": {"text": "Torasemide inhibits angiotensin II-induced vasoconstriction and intracellular calcium increase in the aorta of spontaneously hypertensive rats.", "entity1": "angiotensin II", "entity2": "Torasemide", "span1": [20, 34], "span2": [0, 10]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7573": {"label": 2, "data": {"text": "Administration of chloroquine (50 mg/kg for 7 days po), a denaturant of lysosomes, increased the AQP5 protein level reduced by CTD.", "entity1": "AQP5", "entity2": "chloroquine", "span1": [97, 101], "span2": [18, 29]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12178": {"label": 2, "data": {"text": "However, plasma high-density lipoprotein-cholesterol (HDL-C) and HDL-C/total-C ratio levels and plasma paraoxonase activity were only significantly higher in vitamin E group after 8 weeks.", "entity1": "HDL", "entity2": "vitamin E", "span1": [54, 57], "span2": [158, 167]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4040": {"label": 3, "data": {"text": "In addition, we found that neoechinulin A significantly suppressed the production of neurotoxic inflammatory mediator tumour necrosis factor-\u03b1 (TNF-\u03b1), interleukin-1\u03b2 (IL-1\u03b2), interleukin-6 (IL-6), and prostaglandin E2 (PGE2) in activated BV-2 cells.", "entity1": "interleukin-1\u03b2", "entity2": "neoechinulin A", "span1": [152, 166], "span2": [27, 41]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"8332": {"label": 3, "data": {"text": "Furthermore, inhibition of HO-1 with zinc protoporphyrin IX (ZNPP) significantly reversed the protective effect of Paeoniflorin against radiation-induced damage in EA.hy926 cells.", "entity1": "HO-1", "entity2": "ZNPP", "span1": [27, 31], "span2": [61, 65]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2521": {"label": 8, "data": {"text": "On the basis of our findings with structurally similar arylhydroxylamine metabolites of therapeutic drugs, we hypothesized that the reductive detoxification of arylhydroxylamine carcinogens was catalyzed by NADH cytochrome b5 reductase (b5R) and cytochrome b5 (cyt b5).", "entity1": "b5R", "entity2": "arylhydroxylamine", "span1": [237, 240], "span2": [160, 177]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"14416": {"label": 5, "data": {"text": "Herein, we report the identification and characterization of 3-(5-tert-butyl-isoxazol-3-yl)-2-[(3-chloro-phenyl)-hydrazono]-3-oxo-propionitrile (ESI-09), a novel noncyclic nucleotide EPAC antagonist that is capable of specifically blocking intracellular EPAC-mediated Rap1 activation and Akt phosphorylation, as well as EPAC-mediated insulin secretion in pancreatic \u03b2 cells.", "entity1": "EPAC", "entity2": "nucleotide", "span1": [183, 187], "span2": [172, 182]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9866": {"label": 8, "data": {"text": "In this report, we present cellular and animal models to demonstrate that NQO1 may play only a minor role in metabolic activation of MMC.", "entity1": "NQO1", "entity2": "MMC", "span1": [74, 78], "span2": [133, 136]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15324": {"label": 5, "data": {"text": "IKM-159 was developed and identified as a member of a new class of heterotricyclic glutamate analogues that act as AMPA receptor-selective antagonists.", "entity1": "AMPA receptor", "entity2": "glutamate", "span1": [115, 128], "span2": [83, 92]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2225": {"label": 9, "data": {"text": "Dasatinib (BMS-354825) is a novel orally bioavailable SRC/ABL inhibitor that has activity against multiple imatinib-resistant BCR-ABL isoforms in vitro that is presently showing considerable promise in early-phase clinical trials of chronic myeloid leukemia (CML).", "entity1": "BCR", "entity2": "imatinib", "span1": [126, 129], "span2": [107, 115]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4742": {"label": 3, "data": {"text": "Genistin decreased myosin light chain kinase (MLCK) protein contents and MLCK mRNA expression in IJS, and inhibited both phosphorylation and Mg(2+)-ATPase activity of purified myosin, implicating that the decrease of MLCK contents and inhibition of MLCK activity are involved in the genistin-induced inhibitory effects.", "entity1": "MLCK", "entity2": "Genistin", "span1": [73, 77], "span2": [0, 8]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1511": {"label": 3, "data": {"text": "Many clinical studies, both pre- and post-marketing, have demonstrated the clinical efficacy and safety of sildenafil (Viagra, Pfizer) - the first approved selective PDE inhibitor for the treatment of ED.", "entity1": "PDE", "entity2": "sildenafil", "span1": [166, 169], "span2": [107, 117]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4558": {"label": 3, "data": {"text": "In addition, ethanol induced degradation of DNA methyltransferases (DNMT-1, DNMT-3a, and DNMT-3b), as well as the methyl CpG-binding proteins (MeCP-2, MBD-2 and MBD-3), in MEF cells by the proteasomal pathway.", "entity1": "DNMT-3a", "entity2": "ethanol", "span1": [76, 83], "span2": [13, 20]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9384": {"label": 1, "data": {"text": "In conclusion, cyclothiazide and the 2,3-benzodiazepines seem to bind to different sites on AMPA receptors but exert strong allosteric interactions with one another and with other domains such as the agonist recognition site.", "entity1": "AMPA receptors", "entity2": "cyclothiazide", "span1": [92, 106], "span2": [15, 28]}, "weak_labels": [-1, -1, -1, 1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, 6, -1, -1, -1, -1, -1, -1, 9]},
+	"2101": {"label": 4, "data": {"text": "Together, this pharmacological profile of subtype-selective betaAR antagonists indicates that in this model, beta1AR activation is responsible for the enhanced hippocampal CA3 network activity initiated by isoproterenol.", "entity1": "beta1AR", "entity2": "isoproterenol", "span1": [109, 116], "span2": [206, 219]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8321": {"label": 2, "data": {"text": "Paeoniflorin protects human EA.hy926 endothelial cells against gamma-radiation induced oxidative injury by activating the NF-E2-related factor 2/heme oxygenase-1 pathway.", "entity1": "heme oxygenase-1", "entity2": "Paeoniflorin", "span1": [145, 161], "span2": [0, 12]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"1385": {"label": 2, "data": {"text": "Gemfibrozil induced peroxisome proliferator-responsive element (PPRE)-dependent luciferase activity, which was inhibited by the expression of DeltahPPAR-alpha, the dominant-negative mutant of human PPAR-alpha.", "entity1": "PPRE", "entity2": "Gemfibrozil", "span1": [64, 68], "span2": [0, 11]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10042": {"label": 2, "data": {"text": "Rosiglitazone modestly increased apolipoprotein C-III mRNA and had no effect on expression of the other 2 genes in the liver but increased the expression of glucose transporter 4 and phosphoenolpyruvate carboxykinase in adipose tissue.", "entity1": "phosphoenolpyruvate carboxykinase", "entity2": "Rosiglitazone", "span1": [183, 216], "span2": [0, 13]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"4731": {"label": 2, "data": {"text": "Luciferase reporter assays showed that transcription of FDX1 was synergistically activated by the NR5A family and 8Br-cAMP treatment through two SF-1 binding sites and a CRE-like sequence in a human ovarian granulosa cell line, KGN.", "entity1": "FDX1", "entity2": "8Br-cAMP", "span1": [56, 60], "span2": [114, 122]}, "weak_labels": [-1, -1, -1, 1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8425": {"label": 8, "data": {"text": "Furthermore, knockdown of OPN enhanced cell death caused by other drugs, including paclitaxel, doxorubicin, actinomycin-D, and rapamycin, which are also P-gp substrates.", "entity1": "P-gp", "entity2": "rapamycin", "span1": [153, 157], "span2": [127, 136]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"2029": {"label": 1, "data": {"text": "The activation appears to be due to an increase of GAD affinity for its cofactor, pyridoxal phosphate (PLP).", "entity1": "GAD", "entity2": "pyridoxal phosphate", "span1": [51, 54], "span2": [82, 101]}, "weak_labels": [-1, -1, -1, -1, -1, 1, 2, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 7, -1, -1, -1, -1, -1, -1]},
+	"15195": {"label": 8, "data": {"text": "To evaluate to what extent the regional differences in expression of P-gp and P450 enzymes affect the absorption of a dual substrate, we investigated the transport of darunavir across different small intestinal segments (duodenum, proximal jejunum and ileum).", "entity1": "P450 enzymes", "entity2": "darunavir", "span1": [78, 90], "span2": [167, 176]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, 8, -1, -1, -1, -1]},
+	"812": {"label": 1, "data": {"text": "The modulation of high-voltage-activated (HVA) Ca2+ channels by the prostaglandin E series (PGE1 and PGE2) was studied in the paratracheal ganglion cells.", "entity1": "high-voltage-activated (HVA) Ca2+ channels", "entity2": "PGE1", "span1": [18, 60], "span2": [92, 96]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13115": {"label": 9, "data": {"text": "We failed to observe any significant activation of FAS promoter following exposure to the anti-metabolite 5-fluorouracil, the alkylating drug cisplatin, or the microtubule interfering-agents paclitaxel and vincristine.", "entity1": "FAS promoter", "entity2": "cisplatin", "span1": [51, 63], "span2": [142, 151]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10417": {"label": 3, "data": {"text": "Inhibition corresponded to increased cAMP production caused by rolipram alone or rolipram plus salmeterol and blocked proportionately the phosphorylation and activation of gIV-PLA(2) in FMLP/B-activated eosinophils.", "entity1": "gIV-PLA(2)", "entity2": "salmeterol", "span1": [172, 182], "span2": [95, 105]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"1660": {"label": 5, "data": {"text": "The potent histamine H(1)-receptor antagonist cetirizine (Zyrtec) is a racemic mixture of levocetirizine (now available under the trademark Xyzal and dextrocetirizine.", "entity1": "histamine H(1)-receptor", "entity2": "dextrocetirizine", "span1": [11, 34], "span2": [150, 166]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3823": {"label": 9, "data": {"text": "While none of the phenethylamides (n = 2) were active, most of the anilides (n = 0) turned out to moderately or strongly inhibit 17\u03b2-HSD2.", "entity1": "17\u03b2-HSD2", "entity2": "phenethylamides", "span1": [129, 137], "span2": [18, 33]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14251": {"label": 1, "data": {"text": "Androstanol and androstenol, estrone, 17\u03b2-estradiol, TCPOBOP, and CITCO showed compound-specific but similar affinities for both CARs.", "entity1": "CARs", "entity2": "Androstanol", "span1": [129, 133], "span2": [0, 11]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"13131": {"label": 2, "data": {"text": "RESULT(S): The expression of endometrial ERalpha, PRAB, PRB, and SRC-1 was increased significantly after 1 week of mifepristone, but the increase was no longer seen after 10 weeks.", "entity1": "SRC-1", "entity2": "mifepristone", "span1": [65, 70], "span2": [115, 127]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2861": {"label": 8, "data": {"text": "However, the loss of proliferative capacity of hGSTA4 cells challenged with levels of 4-HNE associated with severe oxidative stress indicates a role of other aldehyde metabolizing enzymes, and/or GSH-electrophile transporter proteins, in providing full cellular protection against 4-HNE toxicity.", "entity1": "hGSTA4", "entity2": "4-HNE", "span1": [47, 53], "span2": [86, 91]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1]},
+	"477": {"label": 5, "data": {"text": "The potency of the antipsychotic drug, risperidone, to antagonize alpha 1A-adrenoceptor-mediated contraction in rat vas deferens and vasoconstriction in rat perfused kidney, and alpha 1B-adrenoceptor-mediated contractions in spleen from guinea-pig and mouse was evaluated and compared to that of alpha 1-adrenoceptor subtype-discriminating antagonists.", "entity1": "alpha 1-adrenoceptor", "entity2": "risperidone", "span1": [296, 316], "span2": [39, 50]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4589": {"label": 3, "data": {"text": "Our previous work, built on the early pioneering multikinase inhibitor LY294002, resulted in the only PI3K vascular-targeted PI3K inhibitor prodrug, SF1126, which has now completed Phase I clinical trials.", "entity1": "PI3K", "entity2": "LY294002", "span1": [102, 106], "span2": [71, 79]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11826": {"label": 1, "data": {"text": "In preclinical studies, the mammalian target of rapamycin (mTOR) in the medial prefrontal cortex and the eukaryotic elongation factor (eEF2) in the hippocampus have been proposed as critical mediators of ketamine's rapid antidepressant actions.", "entity1": "eukaryotic elongation factor", "entity2": "ketamine", "span1": [105, 133], "span2": [204, 212]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4122": {"label": 8, "data": {"text": "Next to Glut-4, the predominant protein influencing glucose metabolism is PPAR\u03b1 and \u03b3 whose expressions were also positively modulated.", "entity1": "Glut-4", "entity2": "glucose", "span1": [8, 14], "span2": [52, 59]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4889": {"label": 3, "data": {"text": "In patients who do not reach the LDL-C target, combination therapy with additional LDL-C lowering drugs (e.g. ezetimibe, bile acid sequestrants or fibrates) should be considered.", "entity1": "LDL", "entity2": "fibrates", "span1": [83, 86], "span2": [147, 155]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 9]},
+	"8500": {"label": 3, "data": {"text": "Histological studies demonstrated that curcumin substantially inhibited OVA-induced eosinophilia in lung tissue.", "entity1": "OVA", "entity2": "curcumin", "span1": [72, 75], "span2": [39, 47]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10989": {"label": 3, "data": {"text": "Tyrosine kinase inhibitors are quinazoline-derived, low molecular weight synthetic molecules that can block the intracellular tyrosine kinase domain of several receptors, including EGFR, Erb2, and vascular endothelial growth factor receptor, and thereby inhibit ligand-induced receptor phosphorylation and abrogate the biologic effect of EGFR signaling.", "entity1": "EGFR", "entity2": "quinazoline", "span1": [338, 342], "span2": [31, 42]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"7698": {"label": 5, "data": {"text": "The inhibitory effect of fenoldopam on insulin-mediated VSMC proliferation was receptor specific, because its effect could be blocked by SCH23390, a D1-like receptor antagonist.", "entity1": "D1-like receptor", "entity2": "SCH23390", "span1": [149, 165], "span2": [137, 145]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, 5, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11578": {"label": 1, "data": {"text": "These results suggest that PDE4B mediates the antipsychotic effects of rolipram in CAR and that the PDE4B-regulated cyclic adenosine monophosphate signaling pathway may play a role in the pathophysiology and pharmacotherapy of psychosis.", "entity1": "PDE4B", "entity2": "rolipram", "span1": [27, 32], "span2": [71, 79]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9455": {"label": 1, "data": {"text": "The EP3 receptor showed the broadest binding profile, and bound sulprostone, M&B-28767, GR63799X, 11-deoxy-PGE1, 16,16-dimethyl-PGE2 and 17-phenyl-PGE2, in addition to PGE2 and PGE1, with Ki values of 0.6-3.7 nM.", "entity1": "EP3", "entity2": "GR63799X", "span1": [4, 7], "span2": [88, 96]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5710": {"label": 3, "data": {"text": "Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17\u03b2-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer.", "entity1": "Type 5 17\u03b2-hydroxysteroid dehydrogenase", "entity2": "indomethacin", "span1": [89, 128], "span2": [36, 48]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14517": {"label": 1, "data": {"text": "Our data demonstrates novel pharmacological mechanism of mesalamine in modulation of cell adhesion and role of PAK1 in APC(min) polyposis.", "entity1": "PAK1", "entity2": "mesalamine", "span1": [111, 115], "span2": [57, 67]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6930": {"label": 8, "data": {"text": "When cultured in YPD medium containing 15% glucose under aerobic conditions, the KGD1 (alpha-ketoglutarate dehydrogenase) gene disrupted mutant produced a lower level of succinate than the wild-type strain, while the SDH1 (succinate dehydrogenase) gene-disrupted mutant produced an increased level of succinate.", "entity1": "SDH1", "entity2": "succinate", "span1": [217, 221], "span2": [301, 310]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1]},
+	"9429": {"label": 3, "data": {"text": "Here we report that alendronate is a potent inhibitor of the protein-tyrosine-phosphatase-meg1 (PTPmeg1).", "entity1": "protein-tyrosine-phosphatase-meg1", "entity2": "alendronate", "span1": [61, 94], "span2": [20, 31]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4542": {"label": 3, "data": {"text": "Given these findings, a unified PK model including the inhibition of MAO-A- and CYP2D6-catalyzed 5-MeO-DMT metabolism by harmaline was developed to describe blood harmaline, 5-MeO-DMT, and bufotenine PK profiles in both wild-type and Tg-CYP2D6 mouse models.", "entity1": "CYP2D6", "entity2": "harmaline", "span1": [237, 243], "span2": [121, 130]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1]},
+	"12421": {"label": 3, "data": {"text": "GTLE pretreatment completely reversed the damaging effects of AlCl3 on AA and superoxide dismutase activity, markedly corrected COX and AChE activities, and moderately improved TGC.", "entity1": "superoxide dismutase", "entity2": "AlCl3", "span1": [78, 98], "span2": [62, 67]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11741": {"label": 1, "data": {"text": "All together, they indicate that aversive property of ethanol is dependent on ethanol action on \u03b12-containing GABA(A)-R.", "entity1": "\u03b12-containing GABA(A)-R", "entity2": "ethanol", "span1": [96, 119], "span2": [78, 85]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12960": {"label": 3, "data": {"text": "Our purpose was to test the impact of single and/or combined treatment with the AT(1)-receptor blocker candesartan and the HMG-CoA reductase inhibitor rosuvastatin on infarct size and neuroscore in transient cerebral ischemia in rats.", "entity1": "AT(1)", "entity2": "candesartan", "span1": [80, 85], "span2": [103, 114]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14653": {"label": 3, "data": {"text": "A series of compounds based on a 4-phenyl-2-phenylaminopyridine scaffold that are potent and selective inhibitors of Traf2- and Nck-interacting kinase (TNIK) activity are described.", "entity1": "TNIK", "entity2": "4-phenyl-2-phenylaminopyridine", "span1": [152, 156], "span2": [33, 63]}, "weak_labels": [-1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8515": {"label": 3, "data": {"text": "To overcome this limitation, we de novo synthesized a conjugate that covalently combines a Gd-based MRI contrast agent, encaged with a chelating agent (DOTA), with pantoprazole, which is a widely used proton pump inhibitor that binds to proton pumps in the stomach and colon.", "entity1": "proton pump", "entity2": "pantoprazole", "span1": [201, 212], "span2": [164, 176]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"12750": {"label": 2, "data": {"text": "The c-Jun absorbed light value/GAPDH absorbed light value of mesenteric arteries in the SHR group was 0.850+/-0.015, which was significantly higher than that in the WKY, imidapril, and irbesartan groups (0.582+/-0.013, 0.743+/-0.012, and 0.789+/-0.013, respectively, P<0.01), and was significantly lower in imidapril group than in irbesartan group (P<0.05).", "entity1": "c-Jun", "entity2": "imidapril", "span1": [4, 9], "span2": [170, 179]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"979": {"label": 3, "data": {"text": "Pretreatment with lysosomal enzyme inhibitors [(2S, 3S)trans-epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester or chloroquine] or proteasome inhibitors (proteasome inhibitor I, MG-132, or lactacystin) decreased the extent of U50,488H-induced down-regulation.", "entity1": "proteasome", "entity2": "lactacystin", "span1": [158, 168], "span2": [193, 204]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, 3, -1, 3, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10862": {"label": 1, "data": {"text": "The identification of 4-methylhistamine as a potent H(4)R agonist is of major importance for future studies to unravel the physiological roles of the H(4)R.", "entity1": "H(4)R", "entity2": "4-methylhistamine", "span1": [150, 155], "span2": [22, 39]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"11610": {"label": 1, "data": {"text": "Our data identify cAspAT as a new member of glyceroneogenesis, transcriptionally regulated by TZD via the control of RORalpha expression by PPARgamma in adipocytes.", "entity1": "RORalpha", "entity2": "TZD", "span1": [117, 125], "span2": [94, 97]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"4058": {"label": 3, "data": {"text": "Neoechinulin A treatment significantly inhibited the generation of reactive oxygen and nitrogen species in A\u03b242-activated BV-2 microglia cells.", "entity1": "A\u03b242", "entity2": "Neoechinulin A", "span1": [107, 111], "span2": [0, 14]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"6914": {"label": 8, "data": {"text": "PSMA acts as a glutamate carboxypeptidase (GCPII) on small molecule substrates, including folate, the anticancer drug methotrexate, and the neuropeptide N-acetyl-l-aspartyl-l-glutamate.", "entity1": "PSMA", "entity2": "N-acetyl-l-aspartyl-l-glutamate", "span1": [0, 4], "span2": [153, 184]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 8, -1, -1, -1, -1, -1]},
+	"3335": {"label": 1, "data": {"text": "We demonstrate that rasagiline protects against cell death induced by the combination of free radicals generated by paraquat and either wild-type or A53T mutant alpha-synuclein over-expression.", "entity1": "A53T", "entity2": "rasagiline", "span1": [149, 153], "span2": [20, 30]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14466": {"label": 1, "data": {"text": "Extracellular loop II modulates GTP sensitivity of the prostaglandin EP3 receptor.", "entity1": "prostaglandin EP3 receptor", "entity2": "GTP", "span1": [55, 81], "span2": [32, 35]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 6, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"10864": {"label": 4, "data": {"text": "Most of the tested H(2)R agonists and imidazole-based H(3)R ligands show micromolar-to-nanomolar range hH(4)R affinity, and these ligands exert different intrinsic hH(4)R activities, ranging from full agonists to inverse agonists.", "entity1": "hH(4)R", "entity2": "imidazole", "span1": [164, 170], "span2": [38, 47]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"3115": {"label": 3, "data": {"text": "Second, probucol, an antiatherogenic compound reported to be an inactivator of ABCA1 reduced hepatic alpha-tocopherol secretion.", "entity1": "ABCA1", "entity2": "probucol", "span1": [79, 84], "span2": [8, 16]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2996": {"label": 1, "data": {"text": "Catalytic-site affinities for cGMP, vardenafil, sildenafil, tadalafil, or 3-isobutyl-1-methylxanthine (IBMX) were respectively weakened 14-, 123-, 30-, 51-, and 43-fold for Y612A; 63-, 511-, 43-, 95- and 61-fold for Q817A; and 59-, 448-, 71-, 137-, and 93-fold for F820A.", "entity1": "Y612A", "entity2": "IBMX", "span1": [173, 178], "span2": [103, 107]}, "weak_labels": [-1, -1, -1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"5313": {"label": 1, "data": {"text": "The tetra-aspartate motif in the trypsinogen activation peptide binds calcium (KD ~1.6 mM), which stimulates autoactivation.", "entity1": "tetra-aspartate motif", "entity2": "calcium", "span1": [4, 25], "span2": [70, 77]}, "weak_labels": [-1, -1, -1, 1, -1, -1, 2, -1, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"8331": {"label": 3, "data": {"text": "Furthermore, inhibition of HO-1 with zinc protoporphyrin IX (ZNPP) significantly reversed the protective effect of Paeoniflorin against radiation-induced damage in EA.hy926 cells.", "entity1": "HO-1", "entity2": "zinc protoporphyrin IX", "span1": [27, 31], "span2": [37, 59]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, 2, -1, -1, -1, -1, 3, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"2052": {"label": 0, "data": {"text": "In this study, we show that mutation of Arg228, a residue in the vicinity of Glu317, to lysine (R228K-Gal-T1) results in a 15-fold higher Glc-T activity, which is further enhanced by LA to nearly 25% of the Gal-T activity of the wild type.", "entity1": "Glc-T", "entity2": "lysine", "span1": [138, 143], "span2": [88, 94]}, "weak_labels": [-1, -1, 0, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"9607": {"label": 1, "data": {"text": "The KATP channel is a heterooligomeric complex of SUR1 subunits of the ATP-binding-cassette superfamily with two nucleotide-binding folds (NBF1 and NBF2) and the pore-forming Kir6.2 subunits.", "entity1": "nucleotide-binding folds", "entity2": "ATP", "span1": [113, 137], "span2": [71, 74]}, "weak_labels": [-1, -1, -1, 1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"15726": {"label": 4, "data": {"text": "Among 12 parabens with linear alkyl chains ranging in length from C1 to C12, heptylparaben (C7) and pentylparaben (C5) showed the most potent ER\u03b1 and ER\u03b2 agonistic activity in the order of 10(-7)M and 10(-8)M, respectively, and the activities decreased in a stepwise manner as the alkyl chain was shortened to C1 or lengthened to C12.", "entity1": "ER\u03b2", "entity2": "pentylparaben", "span1": [150, 153], "span2": [100, 113]}, "weak_labels": [-1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 3, 4, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]},
+	"14035": {"label": 2, "data": {"text": "Here, we report biochemical evidence that mercury alone induces NF-\u03baB activation, resulting in the induced expression of COX-2 and iNOS.", "entity1": "iNOS", "entity2": "mercury", "span1": [131, 135], "span2": [42, 49]}, "weak_labels": [-1, -1, -1, -1, -1, -1, 2, -1, 2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1]}
+}
\ No newline at end of file