diff --git "a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/jLrVDXI7fbo_raw.json" "b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/jLrVDXI7fbo_raw.json" new file mode 100644--- /dev/null +++ "b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/jLrVDXI7fbo_raw.json" @@ -0,0 +1 @@ +{"segments": [{"id": 1, "seek": 2062, "start": 0.88, "end": 20.62, "text": "بسم الله الرحمن الرحيم محاضرتنا ان شاء الله راح تكون Introduction to Special Hemostasis أو Coagulation عملية الـ Hemostasis عادة بتبدأ بحدوث جروح معين لما بيحلث الجروح بتتكون لـ Clot", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 3714, 5016, 46958, 43500, 8315, 16472, 13412, 16606, 21984, 12602, 39319, 6055, 30544, 27193, 882, 281, 11863, 18568, 555, 26632, 34051, 3066, 559, 2776, 6225, 42213, 10632, 2423, 39184, 18568, 555, 26632, 6225, 18513, 3660, 39894, 44510, 10721, 4724, 24401, 2407, 12984, 10874, 32887, 5016, 20449, 9957, 5296, 15042, 4724, 1829, 5016, 1211, 12984, 25724, 32887, 5016, 39894, 2655, 30544, 5296, 39184, 2033, 310], 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مع بعض و بيسددوا الجروح زي ما عندنا راح نشوف مع بعض هلأ كيف بتصير عملية ال activation لـ Platelet Aggregation في عندي مجموعة Agonist هترتبط مع ال Platelets عن طريق Receptors على سطح ال Platelets كل Agonist له Receptor خاص فيه", "tokens": [37746, 22488, 19446, 6055, 2655, 7435, 2304, 3615, 6055, 32887, 5016, 4032, 39896, 47524, 4117, 25720, 25724, 32887, 5016, 39896, 4032, 2423, 39184, 479, 6414, 259, 8799, 4724, 13546, 2655, 3555, 9566, 14407, 20449, 45030, 11242, 4032, 4724, 1829, 3794, 3215, 3215, 14407, 25724, 32887, 5016, 30767, 1829, 19446, 43242, 8315, 12602, 39319, 8717, 8592, 38688, 20449, 45030, 11242, 8032, 1211, 10721, 9122, 33911, 39894, 9381, 13546, 6225, 42213, 10632, 2423, 24433, 5296, 39184, 17461, 15966, 41512, 20167, 8978, 18871, 16254, 3714, 7435, 2304, 2407, 27884, 2725, 266, 468, 8032, 2655, 43500, 3555, 9566, 20449, 2423, 17461, 37220, 18871, 23032, 16572, 4587, 1300, 1336, 830, 15844, 8608, 9566, 5016, 2423, 17461, 37220, 28242, 2725, 266, 468, 46740, 1300, 1336, 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كسكايد بيبدأ بحدوث الجروح وينتهي بتكوين الفيبرين في ما يسمى الـ Coagulation cascade الـ Coagulation cascade يعني مش حاجة تم اكتشافها حديثا وانما هي في ستنيات القرن الماضي حيث انه كان يعتقد ان الـ Clotting عملية التجلط بتحصل عن طريق مجموعة من التفاعلات", "tokens": [6027, 39184, 3066, 559, 2776, 5952, 39894, 2304, 8592, 1829, 8978, 9122, 3794, 4117, 995, 25708, 4724, 1829, 44510, 10721, 4724, 24401, 2407, 12984, 25724, 32887, 5016, 4032, 9957, 47395, 1829, 39894, 4117, 2407, 9957, 27188, 1829, 26890, 9957, 8978, 19446, 7251, 38251, 7578, 2423, 39184, 3066, 559, 2776, 50080, 2423, 39184, 3066, 559, 2776, 50080, 37495, 22653, 37893, 11331, 26108, 3660, 46811, 1975, 4117, 2655, 8592, 31845, 11296, 11331, 16254, 12984, 995, 4032, 7649, 15042, 39896, 8978, 8608, 2655, 22653, 9307, 25062, 2288, 1863, 9673, 46958, 1829, 11331, 1829, 12984, 16472, 3224, 25961, 7251, 34268, 28543, 16472, 2423, 39184, 2033, 310, 783, 6225, 42213, 10632, 16712, 7435, 1211, 9566, 39894, 5016, 36520, 18871, 23032, 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"text": "لفترات طويلة، ظل الاعتقاد السائد إن الـ Intrinsic Pathway هو الـ more important inkleting mechanism يعني ماكانوش ماخدين في الحسبان موضوع الـ tissue factor مع factor VII pathway اللي هو الـ Intrinsic Pathway لكن احنا اليوم بنقول إنهم اتنين بيمشوا side by side، جنبا جنبا طبعا عملية التجلط هذه أو عملية تكوين الفيبرين بتبدأ بجروح", "tokens": [1211, 5172, 2655, 2288, 9307, 23032, 2407, 26895, 3660, 12399, 1357, 116, 1211, 42963, 34268, 4587, 18513, 21136, 16373, 3215, 36145, 2423, 39184, 5681, 81, 1292, 299, 21914, 676, 31439, 2423, 39184, 544, 1021, 11276, 2631, 278, 7513, 37495, 22653, 19446, 41361, 2407, 8592, 3714, 47283, 3215, 9957, 8978, 21542, 35457, 7649, 3714, 2407, 11242, 45367, 2423, 39184, 12404, 5952, 20449, 5952, 48087, 18590, 13672, 1829, 31439, 2423, 39184, 5681, 81, 1292, 299, 21914, 676, 44381, 1975, 5016, 8315, 45595, 20498, 44945, 39648, 36145, 16095, 1975, 2655, 1863, 9957, 4724, 32640, 8592, 14407, 1252, 538, 1252, 12399, 10874, 1863, 3555, 995, 10874, 1863, 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الـ", "probability": 0.97021484375}, {"start": 1515.96, "end": 1516.52, "word": " Coagulation", "probability": 0.9578450520833334}, {"start": 1516.52, "end": 1516.92, "word": " مش", "probability": 0.94384765625}, {"start": 1516.92, "end": 1517.24, "word": " لازم", "probability": 0.994140625}, {"start": 1517.24, "end": 1517.54, "word": " تضل", "probability": 0.7472330729166666}, {"start": 1517.54, "end": 1518.0, "word": " شغالة", "probability": 0.9957275390625}, {"start": 1518.0, "end": 1518.12, "word": " على", "probability": 0.9658203125}, {"start": 1518.12, "end": 1518.48, "word": " طول", "probability": 0.99169921875}, {"start": 1518.48, "end": 1519.22, "word": " لازم", "probability": 0.9934895833333334}, {"start": 1519.22, "end": 1519.56, "word": " تيجي", "probability": 0.978271484375}, {"start": 1519.56, "end": 1520.16, "word": " أشياء", "probability": 0.966796875}, {"start": 1520.16, "end": 1521.82, "word": " توقف", "probability": 0.79296875}, {"start": 1521.82, "end": 1522.2, 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{"start": 1534.13, "end": 1534.35, "word": " أنتوا", "probability": 0.720703125}, {"start": 1534.35, "end": 1534.77, "word": " شايفين", "probability": 0.980224609375}, {"start": 1534.77, "end": 1534.97, "word": " في", "probability": 0.81103515625}, {"start": 1534.97, "end": 1535.29, "word": " عندي", "probability": 0.979248046875}, {"start": 1535.29, "end": 1535.79, "word": " أكتر", "probability": 0.99365234375}, {"start": 1535.79, "end": 1536.05, "word": " من", "probability": 0.99609375}, {"start": 1536.05, "end": 1537.09, "word": " anticoagulant", "probability": 0.9384765625}, {"start": 1537.09, "end": 1537.59, "word": " pathway", "probability": 0.9794921875}, {"start": 1537.59, "end": 1538.75, "word": " في", "probability": 0.85205078125}, {"start": 1538.75, "end": 1539.07, "word": " عندي", "probability": 0.9814453125}, {"start": 1539.07, "end": 1539.31, "word": " ال", "probability": 0.79052734375}, {"start": 1539.31, "end": 1539.47, "word": " tissue", "probability": 0.93017578125}, {"start": 1539.47, "end": 1540.09, "word": " factor", "probability": 0.8662109375}, {"start": 1540.09, "end": 1541.15, "word": " pathway", "probability": 0.97509765625}, {"start": 1541.15, "end": 1541.85, "word": " inhibitor", "probability": 0.94384765625}, {"start": 1541.85, "end": 1542.21, "word": " في", "probability": 0.8662109375}, {"start": 1542.21, "end": 1542.61, "word": " عندي", "probability": 0.9794921875}, {"start": 1542.61, "end": 1543.09, "word": " ال", "probability": 0.91064453125}, {"start": 1543.09, "end": 1544.19, "word": " antithrombin", "probability": 0.801171875}, {"start": 1544.19, "end": 1545.05, "word": " 3", "probability": 0.4853515625}], "temperature": 1.0}, {"id": 61, "seek": 157379, "start": 1547.61, "end": 1573.79, "text": "طيب نيجي لأول pathway اللي هي في الـ Anti-coagulation اللي هي الـ Anti-thrombin pathway Anti-thrombin يعتبر أهم inhibitor لـ coagulation للثرمبين بيشكل حوالي 80% of ثرمبين inhibitory activity in plasma يعني هو أهم pathway عندنا الـ Anti-thrombin عادة بيعمل inhibition directly", "tokens": [9566, 1829, 3555, 8717, 1829, 7435, 1829, 5296, 10721, 12610, 18590, 13672, 1829, 39896, 8978, 2423, 39184, 27757, 12, 1291, 559, 2776, 13672, 1829, 39896, 2423, 39184, 27757, 12, 392, 4397, 13496, 18590, 27757, 12, 392, 4397, 13496, 7251, 34268, 26890, 5551, 16095, 20406, 3029, 5296, 39184, 598, 559, 2776, 24976, 12984, 2288, 2304, 3555, 9957, 4724, 1829, 8592, 28820, 11331, 2407, 6027, 1829, 4688, 4, 295, 38637, 2288, 2304, 3555, 9957, 49858, 827, 5191, 294, 22564, 37495, 22653, 31439, 5551, 16095, 18590, 43242, 8315, 2423, 39184, 27757, 12, 392, 4397, 13496, 6225, 18513, 3660, 4724, 1829, 25957, 1211, 20406, 849, 3838], "avg_logprob": -0.1612560717226232, "compression_ratio": 1.7069767441860466, "no_speech_prob": 1.0907649993896484e-05, "words": [{"start": 1547.6100000000001, "end": 1548.63, "word": "طيب", "probability": 0.921875}, {"start": 1548.63, "end": 1549.09, "word": " نيجي", "probability": 0.8223876953125}, {"start": 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هيتكمل ال pathway وبالتالي مش هيتكون الفيبرين وهكذا هو يقوم بدوره ك anticoagulant طيب نشوف تفاصيل أكتر عن الموضوع ال antithrombin", "tokens": [1211, 1211, 12984, 2288, 2304, 3555, 9957, 35525, 5172, 995, 4117, 2655, 13063, 6225, 8592, 25720, 20666, 28814, 11242, 31845, 3660, 6156, 995, 4117, 2655, 13063, 6225, 8592, 25720, 4967, 23032, 3555, 3615, 995, 31439, 5296, 15042, 7251, 25957, 1211, 20406, 849, 5296, 1211, 12984, 2288, 2304, 3555, 9957, 35525, 5172, 995, 4117, 2655, 13063, 6225, 8592, 25720, 5551, 4117, 25708, 8032, 36081, 30543, 5172, 2423, 18590, 5296, 33456, 29538, 2423, 6771, 9673, 5172, 32887, 11242, 3660, 6055, 4587, 20498, 47525, 13063, 11296, 44381, 31439, 23032, 6027, 15042, 6225, 42213, 1211, 11296, 3461, 37893, 8032, 36081, 24793, 1211, 2423, 18590, 4032, 3555, 6027, 2655, 6027, 1829, 37893, 8032, 36081, 30544, 27188, 1829, 26890, 9957, 37037, 4117, 15730, 31439, 7251, 4587, 20498, 47525, 13063, 3224, 9122, 2511, 2789, 559, 425, 394, 23032, 1829, 3555, 8717, 8592, 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active، factor 11، factor 12 active بعمل inhibition لل complement enzyme C1 كيف بتصير عملية ال inhibition لما بيصير جروح بتطلع مادة الهيبرانسلفات هذه المادة بتطلع من ال endothelial cells", "tokens": [3555, 25957, 1211, 20406, 849, 30767, 1829, 19446, 12174, 1211, 8315, 4724, 8592, 28820, 3714, 3555, 33599, 2288, 34051, 4724, 8592, 28820, 5551, 3794, 32277, 1829, 24976, 5718, 104, 2288, 1863, 3555, 9957, 49429, 5952, 1266, 4967, 20666, 28814, 11242, 31845, 3660, 5296, 33456, 3224, 4724, 25957, 1211, 20406, 849, 5296, 661, 6771, 30767, 1829, 5952, 1722, 4967, 12399, 5952, 2975, 12399, 5952, 2272, 4967, 4724, 25957, 1211, 20406, 849, 24976, 17103, 24521, 383, 16, 9122, 33911, 39894, 9381, 13546, 6225, 42213, 10632, 2423, 20406, 849, 5296, 15042, 4724, 1829, 9381, 13546, 10874, 32887, 5016, 39894, 9566, 1211, 3615, 3714, 18513, 3660, 2423, 3224, 1829, 26890, 7649, 3794, 46538, 9307, 29538, 9673, 18513, 3660, 39894, 9566, 1211, 3615, 9154, 2423, 917, 900, 338, 831, 5438], "avg_logprob": 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{"start": 1627.53, "end": 1628.03, "word": " مادة", "probability": 0.9759114583333334}, {"start": 1628.03, "end": 1629.23, "word": " الهيبرانسلفات", "probability": 0.752105712890625}, {"start": 1629.23, "end": 1629.53, "word": " هذه", "probability": 0.86962890625}, {"start": 1629.53, "end": 1629.89, "word": " المادة", "probability": 0.9873046875}, {"start": 1629.89, "end": 1630.41, "word": " بتطلع", "probability": 0.8831787109375}, {"start": 1630.41, "end": 1630.75, "word": " من", "probability": 0.9951171875}, {"start": 1630.75, "end": 1631.15, "word": " ال", "probability": 0.96728515625}, {"start": 1631.15, "end": 1631.75, "word": " endothelial", "probability": 0.8388671875}, {"start": 1631.75, "end": 1632.15, "word": " cells", "probability": 0.8544921875}], "temperature": 1.0}, {"id": 64, "seek": 165753, "start": 1632.79, "end": 1657.53, "text": "مادة شبيهة بالـ Heparin هذه المادة راح تروح و هي مرتبطة بالـ Antithrombin لما بترتبط فيه بتعمل له conformational changes بتغير الشكل أو التركيبة بتاعته بحيث أنه يصير سهل عليه أنه يرتبط بالإنزيم أو ب��لإنزايم و يعمله inactivation", "tokens": [2304, 18513, 3660, 13412, 21292, 3224, 3660, 20666, 39184, 634, 2181, 259, 29538, 9673, 18513, 3660, 12602, 39319, 6055, 32887, 5016, 4032, 39896, 3714, 43500, 3555, 9566, 3660, 20666, 39184, 5130, 355, 4397, 13496, 5296, 15042, 39894, 43500, 3555, 9566, 8978, 3224, 39894, 25957, 1211, 46740, 18975, 1478, 2962, 39894, 17082, 13546, 25124, 28820, 34051, 16712, 31747, 1829, 49401, 39894, 995, 34268, 3224, 4724, 5016, 1829, 12984, 14739, 3224, 7251, 9381, 13546, 8608, 3224, 1211, 47356, 14739, 3224, 7251, 43500, 3555, 9566, 20666, 28814, 1863, 11622, 32640, 34051, 20666, 28814, 1863, 11622, 995, 32640, 4032, 7251, 25957, 43761, 294, 23397, 399], "avg_logprob": -0.16007965803146362, "compression_ratio": 1.6590909090909092, "no_speech_prob": 4.5180320739746094e-05, "words": [{"start": 1632.79, "end": 1633.39, "word": "مادة", "probability": 0.8466796875}, {"start": 1633.39, "end": 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"probability": 0.7728678385416666}, {"start": 1684.3, "end": 1684.94, "word": " هلأ", "probability": 0.5733235677083334}, {"start": 1684.94, "end": 1685.14, "word": " هاي", "probability": 0.5411376953125}, {"start": 1685.14, "end": 1685.46, "word": " عندنا", "probability": 0.776123046875}, {"start": 1685.46, "end": 1686.2, "word": " الهيبرين", "probability": 0.9556640625}], "temperature": 1.0}, {"id": 66, "seek": 171064, "start": 1686.84, "end": 1710.64, "text": "في عندى الـ Antithrombin ارتباط الهيبرين مع الـ Antithrombin هيغير شكل الـ Antithrombin شفتين كيف صار شكله؟ فهذا الشكل هيصير موائم لشكل factor 10 active و factor 2 active اللي هو الـ Thrombin وبالتالي هيصير ارتباط بينهم و هيصير هذا ال factor اللي كان active هيصير inactive", "tokens": [41185, 43242, 7578, 2423, 39184, 5130, 355, 81, 3548, 259, 1975, 43500, 3555, 41193, 2423, 3224, 1829, 26890, 9957, 20449, 2423, 39184, 5130, 355, 81, 3548, 259, 39896, 17082, 13546, 13412, 28820, 2423, 39184, 5130, 355, 81, 3548, 259, 13412, 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{"start": 1730.54, "end": 1732.94, "word": " factor", "probability": 0.59423828125}, {"start": 1732.94, "end": 1733.3, "word": " اللي", "probability": 0.983154296875}, {"start": 1733.3, "end": 1733.56, "word": " صار", "probability": 0.981689453125}, {"start": 1733.56, "end": 1734.28, "word": " inactive", "probability": 0.7880859375}, {"start": 1734.28, "end": 1734.7, "word": " مع", "probability": 0.97900390625}, {"start": 1734.7, "end": 1735.04, "word": " الـ", "probability": 0.72314453125}, {"start": 1735.04, "end": 1735.68, "word": " Antithrombine", "probability": 0.84091796875}, {"start": 1735.68, "end": 1736.08, "word": " وهيك", "probability": 0.7652994791666666}, {"start": 1736.08, "end": 1736.58, "word": " بنكون", "probability": 0.94189453125}], "temperature": 1.0}, {"id": 68, "seek": 176667, "start": 1737.89, "end": 1766.67, "text": "نيجي للـ pathway التاني اللي هو protein C pathway خلّوا بالكم إحنا بنحكي عن anticoagulant pathway يعني هيمشي الكسكيت ويكون عندي الـ coagulation 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1790.84, "word": " البروتين", "probability": 0.9580078125}, {"start": 1790.84, "end": 1791.14, "word": " C", "probability": 0.974609375}, {"start": 1791.14, "end": 1792.2, "word": " هيصير", "probability": 0.9513346354166666}, {"start": 1792.2, "end": 1792.82, "word": " Active", "probability": 0.5107421875}, {"start": 1792.82, "end": 1793.58, "word": " بروتين", "probability": 0.8121337890625}, {"start": 1793.58, "end": 1793.94, "word": " C", "probability": 0.978515625}, {"start": 1793.94, "end": 1794.64, "word": " فلقيت", "probability": 0.8223876953125}, {"start": 1794.64, "end": 1794.84, "word": " لما", "probability": 0.904296875}, {"start": 1794.84, "end": 1795.2, "word": " بيصير", "probability": 0.8936767578125}, {"start": 1795.2, "end": 1795.74, "word": " activation", "probability": 0.94970703125}, {"start": 1795.74, "end": 1796.36, "word": " لبروتين", "probability": 0.9764404296875}, {"start": 1796.36, "end": 1796.62, "word": " C", "probability": 0.99365234375}], "temperature": 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