diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/0ya7Xzqlzfg.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/0ya7Xzqlzfg.srt
new file mode 100644
index 0000000000000000000000000000000000000000..d3fb66dd5c23c275016058e48411ad261e8a17f9
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/0ya7Xzqlzfg.srt
@@ -0,0 +1,1138 @@
+1
+00:00:00,890 --> 00:00:05,870
+كرياتينين المادة الأخرى اللي بتشيك على وظائف الكلى
+
+2
+00:00:05,870 --> 00:00:09,810
+is a non-protein nitrogen waste product formed in
+
+3
+00:00:09,810 --> 00:00:14,210
+muscle. مادة الكرياتينين هي إحدى المواد اللي بتحتوي
+
+4
+00:00:14,210 --> 00:00:19,230
+على نيتروجين ولا تعتبر من ضمن البروتينات وهي فضلات
+
+5
+00:00:19,230 --> 00:00:23,470
+بتتكون في العضلات ولازم الجسم يتخلص من هذه الفضلات
+
+6
+00:00:23,470 --> 00:00:30,500
+ويخرجها عن طريق الـ urine. كيف؟ العضلة في حالة الـ
+
+7
+00:00:30,500 --> 00:00:35,820
+contraction، الإنقباضات، وفي حالة الشغل، ولما
+
+8
+00:00:35,820 --> 00:00:39,840
+يكون بدها طاقة، جواها في العضلات مادة اسمها
+
+9
+00:00:39,840 --> 00:00:45,220
+الكرياتين. هذه المادة بتستخدمها العضلة من أجل
+
+10
+00:00:45,220 --> 00:00:50,320
+الحصول على الطاقة، ومن أجل أداء العمليات الحيوية
+
+11
+00:00:50,320 --> 00:00:54,950
+الخاصة فيها. لكن في حال صار في عندي relaxation
+
+12
+00:00:54,950 --> 00:01:00,030
+استرخاء في العضلة، هتبطل تستخدم مادة الكرياتين
+
+13
+00:01:00,030 --> 00:01:04,850
+فاللي بيصير في حالة الـ relaxation للعضلة بيصير
+
+14
+00:01:04,850 --> 00:01:11,230
+عندي degradation تكسير لمادة الكرياتين وبتتحول هذه
+
+15
+00:01:11,230 --> 00:01:16,610
+المادة إلى مادة أخرى اسمها الكرياتينين اللي احنا
+
+16
+00:01:16,610 --> 00:01:22,120
+بدنا إياه، إذًا الكرياتينين المادة تبعتنا هي waste
+
+17
+00:01:22,120 --> 00:01:28,020
+product فضلات جاية من وين؟ جاية من تكسير مادة الـ
+
+18
+00:01:28,020 --> 00:01:32,500
+creatine في حالة الـ relaxation للعضلة
+
+19
+00:01:33,820 --> 00:01:40,600
+إذًا الكرياتين ممكن يتم منه نزع ماء وبتحول
+
+20
+00:01:40,600 --> 00:01:45,860
+لكرياتينين، أو الكرياتين ممكن يكون مربوط بـ
+
+21
+00:01:45,860 --> 00:01:49,400
+phosphate group. لو نزعتي منه الـ phosphate group
+
+22
+00:01:49,400 --> 00:01:54,400
+بتحول لكرياتينين، وهذه العملية بتصير في حالة الـ
+
+23
+00:01:54,400 --> 00:01:59,200
+relaxation، لما العضلة ما بدها مادة الكرياتين فيها
+
+24
+00:01:59,200 --> 00:02:03,100
+فبتم تحويل الكرياتين لكرياتينين
+
+25
+00:02:04,590 --> 00:02:08,470
+طبعًا هذه المعلومات فقط، يعني لازم تعرفوا
+
+26
+00:02:08,470 --> 00:02:13,730
+أن الكرياتينين من وين جاي؟  للمعرفة، filtered by the kidney
+
+27
+00:02:13,730 --> 00:02:17,890
+and excreted in the urine. هذا الكرياتينين ممنوع
+
+28
+00:02:17,890 --> 00:02:22,710
+يظل في الدم لأنه فضلة بتكون في العضلة، بعد هيك بيرجع
+
+29
+00:02:22,710 --> 00:02:28,390
+على الدم، فلازم الجسم يتخلص منه، فيروح الكرياتينين
+
+30
+00:02:28,390 --> 00:02:33,570
+على الكلى، والكلى بتعمل له excretion، تخرجه مع الـ
+
+31
+00:02:33,570 --> 00:02:40,030
+urine. الكرياتينين بيفلتر بسهولة في الـ glomerular
+
+32
+00:02:40,030 --> 00:02:46,150
+filtration، وليس مستعمل بسبب الـ tubule.  حقيقة يا جماعة
+
+33
+00:02:46,150 --> 00:02:52,840
+إن كل الكرياتينين بيصير له excretion مع اليورين. إذًا
+
+34
+00:02:52,840 --> 00:02:57,960
+الكرياتينين مادة فضلات، waste product بيصير لها
+
+35
+00:02:57,960 --> 00:03:03,560
+فلترة عن طريق الكلى وبتخرج مع الـ urine كلها، إلا
+
+36
+00:03:03,560 --> 00:03:09,140
+جزء بسيط جدًا جدًا، يعني أعشار من الكرياتينين بيبقوا
+
+37
+00:03:09,140 --> 00:03:14,100
+في الدم. يعني جزء بسيط بيصير له reabsorption، بتم
+
+38
+00:03:14,100 --> 00:03:18,480
+إعادة امتصاصه للدم، بسيط جدًا، مش زي الـ urea.
+
+39
+00:03:18,480 --> 00:03:22,520
+الـ urea حكينا 40% بيصير له إعادة امتصاص، أما
+
+40
+00:03:22,520 --> 00:03:26,160
+الكرياتينين كله بيطلع مع الـ urine برا الجسم
+
+41
+00:03:26,160 --> 00:03:31,790
+باستثناء جزء ضئيل جدًا بيبقى في الدم. The amount
+
+42
+00:03:31,790 --> 00:03:36,390
+excreted daily is a function of muscle mass and is
+
+43
+00:03:36,390 --> 00:03:40,710
+not affected too much by diet. تركيز الكرياتينين يا
+
+44
+00:03:40,710 --> 00:03:47,040
+جماعة ما بيتأثر بالأكل، مش زي اليوريا، تمام؟ تركيز
+
+45
+00:03:47,040 --> 00:03:51,900
+الكرياتينين بيعتمد على الـ muscle mass، حجم العضلة
+
+46
+00:03:51,900 --> 00:03:57,100
+هنا الرجال عندهم تركيز الكرياتينين في الدم أعلى
+
+47
+00:03:57,100 --> 00:04:02,280
+من النساء، ليش؟ لأن الرجال الـ muscle mass، حجم العضلة
+
+48
+00:04:02,280 --> 00:04:08,200
+عندهم أكبر، وبالتالي بتكون عندهم فضلات أكثر، بتكون
+
+49
+00:04:08,200 --> 00:04:14,700
+عندهم كرياتينين أكثر، تمام؟ فالكرياتينين تركيزه
+
+50
+00:04:14,700 --> 00:04:18,960
+عند الرجال أعلى من النساء، بإيش بسيط حسب الـ muscle
+
+51
+00:04:18,960 --> 00:04:23,020
+mass. طيب عند الأطفال حجم العضلات كتير صغيرة
+
+52
+00:04:23,020 --> 00:04:28,040
+وبالتالي تركيز الكرياتينين في الدم عندهم بيكون
+
+53
+00:04:28,040 --> 00:04:33,580
+قليل جدًا جدًا، حسب الـ muscle mass، حسب حجم العضلة
+
+54
+00:04:33,580 --> 00:04:34,380
+تمام؟
+
+55
+00:04:36,820 --> 00:04:40,420
+الـ clinical significance، أهمية الفحص. «Elevated
+
+56
+00:04:40,420 --> 00:04:44,200
+creatinine» is found with abnormal renal function.
+
+57
+00:04:44,200 --> 00:04:48,180
+الناس اللي عندها مشكلة في الكلى، معناه الكلى مش
+
+58
+00:04:48,180 --> 00:04:52,300
+هتقدر تعمل فلترة، تمام؟ وبالتالي مش هتطلع
+
+59
+00:04:52,300 --> 00:04:55,960
+الكرياتينين مع الـ urine، فبيضل الكرياتينين محجوز
+
+60
+00:04:55,960 --> 00:05:01,940
+في الدم ويزيد تركيزه. هذا الاختصار اختصار لـ
+
+61
+00:05:01,940 --> 00:05:08,650
+glomerular filtration rate، معدل الفلترة، تمام، لـ
+
+62
+00:05:08,650 --> 00:05:12,630
+glomerulus، هذا العضو اللي موجود في الكلى، موجود في
+
+63
+00:05:12,630 --> 00:05:16,890
+تركيبة الكلى، المسؤول عن الفلترة اللي بيفلتر الدم
+
+64
+00:05:16,890 --> 00:05:21,470
+وبيطلع المكونات اللي بدنا نتخلص منها مع الـ urine، الفضلات
+
+65
+00:05:21,470 --> 00:05:27,490
+وبرجع الشغلات المهمة للدم. Therefore, any condition
+
+66
+00:05:27,490 --> 00:05:31,250
+that reduces the glomerular filtration rate will
+
+67
+00:05:31,250 --> 00:05:37,770
+result in. أي حالة تؤدي إلى نقص في معدل الفلترة
+
+68
+00:05:37,770 --> 00:05:43,490
+يعني لو الكلى انصابت بمشكلة، هذه المشكلة أثرت على
+
+69
+00:05:43,490 --> 00:05:48,630
+الكلى وبالتالي الكلى بطلت تقدر تفلتر. إذًا هذه الـ
+
+70
+00:05:48,630 --> 00:05:53,230
+condition، قللت من معدل الفلترة من الـ glomerulus
+
+71
+00:05:53,230 --> 00:05:57,860
+filtration rate. لما الـ kidney تصير قدرتها على
+
+72
+00:05:57,860 --> 00:06:04,240
+الفلترة ضعيفة، معناها مش هتقدر تطلع الكرياتينين مع
+
+73
+00:06:04,240 --> 00:06:07,800
+الـ urine، مش هتطلعوا برا الجسم، وهيبقوا محجوز في
+
+74
+00:06:07,800 --> 00:06:12,940
+الدم، والـ result إن إيش هيصير؟ A less excretion
+
+75
+00:06:12,940 --> 00:06:18,020
+from the body. كمية الكرياتينين اللي هتخرج مع الـ
+
+76
+00:06:18,020 --> 00:06:23,030
+urine هتكون قليلة، with a consequent rise in the
+
+77
+00:06:23,030 --> 00:06:25,990
+concentration of creatinine in the blood. إذًا
+
+78
+00:06:25,990 --> 00:06:29,550
+الكرياتينين كميته اللي بتطلع برا الجسم قليلة، وين
+
+79
+00:06:29,550 --> 00:06:33,430
+هتروح الكرياتينين؟ هيبقوا محجوز في الدم ويزيد
+
+80
+00:06:33,430 --> 00:06:39,450
+تركيزه في الدم، تمام؟ إذًا أي حالة مرضية بتأثر على
+
+81
+00:06:39,450 --> 00:06:44,770
+الكلى وبالتالي بتقلل من معدل فلترة الكلى، هيؤدي
+
+82
+00:06:44,770 --> 00:06:49,510
+ذلك إلى ارتفاع الكرياتينين في الدم ومنع خروجه مع
+
+83
+00:06:49,510 --> 00:06:53,850
+اليورين. Serum creatinine is a better indicator
+
+84
+00:06:53,850 --> 00:06:58,070
+of renal function than either of the blood
+
+85
+00:06:58,070 --> 00:07:01,270
+urea nitrogen or the uric acid. يعتبر فحص
+
+86
+00:07:01,270 --> 00:07:05,970
+الكرياتينين أفضل من فحص اليوريا وأفضل من فحص الـ
+
+87
+00:07:05,970 --> 00:07:10,230
+uric acid، المادة الثالثة، ليش؟ لأن فحص الكرياتينين
+
+88
+00:07:10,230 --> 00:07:16,850
+يعتبر specific للـ renal function، فحص متخصص للكلى
+
+89
+00:07:16,850 --> 00:07:24,490
+ومشاكله، يعني مثلًا لو انصاب المريض بمرض معين أو لا،
+
+90
+00:07:24,490 --> 00:07:28,290
+خلينا نفهمها بشكل آخر، اليوريا حكينا بتتأثر
+
+91
+00:07:28,290 --> 00:07:32,570
+بالأكل، بتتأثر بالجفاف، يعني بتزيد في حالات غير
+
+92
+00:07:32,570 --> 00:07:37,030
+مشاكل الكلى، لكن الكرياتينين فقط بيزداد
+
+93
+00:07:37,030 --> 00:07:42,420
+الكرياتينين إذا كان عندي مشكلة في الكلى بس، لكن أي
+
+94
+00:07:42,420 --> 00:07:47,420
+مشكلة في مكان آخر، في organ آخر، الكرياتينين ما
+
+95
+00:07:47,420 --> 00:07:52,760
+بيتأثر. الكرياتينين فقط بيتأثر إذا الكلى صار فيها
+
+96
+00:07:52,760 --> 00:07:57,320
+خلل، وما بيتأثر إذا أكلت أكلات مليانة ولا لأ
+
+97
+00:07:57,320 --> 00:08:02,420
+بالبروتينات، ما بيتأثر بالجفاف، يعني لو صار في جفاف
+
+98
+00:08:02,420 --> 00:08:07,920
+ما بيتأثر تركيزه. عشان هيك هو أفضل من
+
+99
+00:08:07,920 --> 00:08:14,100
+الفحوصات الأخرى لأنه متخصص لمشاكل الكلى وما بيزيد
+
+100
+00:08:14,100 --> 00:08:21,020
+إلا إذا كان في عندي مشكلة في الكلى. طبعًا بيكمل بالـ
+
+101
+00:08:21,020 --> 00:08:24,080
+clinical significance for renal transplant
+
+102
+00:08:24,080 --> 00:08:28,160
+patients، and an increase in serum creatinine of 2
+
+103
+00:08:28,160 --> 00:08:31,420
+milligrams per liter has been used as a criterion
+
+104
+00:08:31,420 --> 00:08:35,840
+of establishing rejection. هنا كمان فايدة لفحص
+
+105
+00:08:35,840 --> 00:08:40,380
+الكرياتينين، الناس اللي بتزرع كلى، طبعًا أنتم
+
+106
+00:08:40,380 --> 00:08:44,420
+بتعرفوا الزراعة مشاكلها، الـ rejection، الرفض، تمام؟ وهل
+
+107
+00:08:44,420 --> 00:08:49,000
+الجسم هيقبل العضو المزروع فيه ولا لأ؟ هيهاجمه من
+
+108
+00:08:49,000 --> 00:08:52,320
+قبل مناعة الشخص ولا لأ؟ طبعًا الإنسان اللي بيزرع
+
+109
+00:08:52,320 --> 00:08:56,900
+كلى، بعد الزراعة لازم أتابعه، بتابعه بأي فحص؟ بفحص
+
+110
+00:08:56,900 --> 00:09:01,300
+الكرياتينين، كل يومين، ثلاثة، أربعة، بعمله الفحص
+
+111
+00:09:01,890 --> 00:09:07,430
+ووجدت أنه الكرياتينين بدأ يرتفع شوية، بفهم
+
+112
+00:09:07,430 --> 00:09:12,550
+أنه ممكن احتمال يصير في عندي rejection. هذه الفايدة
+
+113
+00:09:12,550 --> 00:09:16,310
+للفحص فقط، هذا اللي بدنا نفهمه. أما 2 milligrams per
+
+114
+00:09:16,310 --> 00:09:21,270
+liter وزاد وقد إيش مقدار الزيادة مش ضروري للحفظ،
+
+115
+00:09:21,270 --> 00:09:28,400
+تمام؟ في الناس الأخرى، تغيير الكرياتينين من 2 ملي
+
+116
+00:09:28,400 --> 00:09:33,930
+جرام على لتر، يمثل 20% تقريبًا. أيضًا
+
+117
+00:09:33,930 --> 00:09:38,650
+الكرياتينين فحص غير أنه مهم لمتابعة وظائف الكلى
+
+118
+00:09:38,650 --> 00:09:44,010
+ولمتابعة في حالات الزراعة، برضه مهم، إنه لو
+
+119
+00:09:44,010 --> 00:09:49,910
+الكرياتينين في الدم اتغير بمعدل 2 milligrams per
+
+120
+00:09:49,910 --> 00:09:55,430
+liter، يعني ارتفع، would represent هذا معناه مؤشر
+
+121
+00:09:55,430 --> 00:10:02,960
+ودليل إنه 20% من الكلى loss للـ function تبعتها، 20
+
+122
+00:10:02,960 --> 00:10:09,380
+% من الكلى فقدت وظيفتها، تمام؟ يعني لو اتغير
+
+123
+00:10:09,380 --> 00:10:14,600
+الكرياتينين في الدم بمقدار 2 milligrams per liter،
+
+124
+00:10:14,600 --> 00:10:22,180
+يعني ارتفع، هذا مؤشر إن 20% من وظيفة الكلى فقدت
+
+125
+00:10:22,180 --> 00:10:27,240
+وظيفتها، وفي احتمال في المستقبل يصير في عندنا فشل كلوي
+
+126
+00:10:28,710 --> 00:10:35,910
+إذًا هنا بيبين لكم أهمية الـ creatinine test للـ
+
+127
+00:10:35,910 --> 00:10:40,370
+specimen. One can analyze serum, plasma, or diluted
+
+128
+00:10:40,370 --> 00:10:46,090
+urine. إذًا سيرم، بلازما، الـ urine برضه ممكن أفحص فيه
+
+129
+00:10:46,090 --> 00:10:48,910
+الـ creatinine، بس لأن تركيز الـ creatinine في الـ
+
+130
+00:10:48,910 --> 00:10:53,190
+urine عالي كتير فلازم أخفف العينة قبل ما أستخدمها
+
+131
+00:10:53,190 --> 00:10:57,490
+عشان هيك كتبنا لكم الـ diluted urine. The common
+
+132
+00:10:57,490 --> 00:11:01,650
+anticoagulants, fluoride and heparin, don't cause
+
+133
+00:11:01,650 --> 00:11:06,370
+interference. يعني الـ anticoagulants المسموح فيه
+
+134
+00:11:06,370 --> 00:11:10,910
+لما بدي أفصل البلازما إما fluoride أو heparin
+
+135
+00:11:10,910 --> 00:11:15,130
+«though heparin, which cannot be formulated as an
+
+136
+00:11:15,130 --> 00:11:19,230
+ammonium salt, must be avoided in enzymatic
+
+137
+00:11:19,230 --> 00:11:23,650
+methods that measure ammonia production». بيقول لي
+
+138
+00:11:23,650 --> 00:11:29,540
+إن أملاح الـ ammonium heparin،
+
+139
+00:11:29,540 --> 00:11:34,240
+ممنوعة. يعني الـ ammonium heparin ممنوع كـ
+
+140
+00:11:34,240 --> 00:11:39,780
+anticoagulant. ليش؟ وخاصة لو طريقة الـ kit هي
+
+141
+00:11:39,780 --> 00:11:44,900
+enzymatic methods، طريقة شغل الكرياتينين لو كانت
+
+142
+00:11:44,900 --> 00:11:49,140
+enzymatic methods، ممنوع تستخدمي الـ ammonium
+
+143
+00:11:49,140 --> 00:11:53,600
+heparin كـ anticoagulant، لأن بهذه الطريقة في الـ
+
+144
+00:11:53,600 --> 00:11:59,680
+reaction هيكون فيه إنتاج للأمونيا. تمام؟ طب وإنتِ
+
+145
+00:11:59,680 --> 00:12:04,120
+أصلًا الـ anticoagulant فيه أمونيوم، الأمونيوم لو
+
+146
+00:12:04,120 --> 00:12:09,820
+انكسرت الأمونيوم هي NH4، لو انكسرت هتعطيكي أمونيا
+
+147
+00:12:09,820 --> 00:12:16,120
+NH3، وبالتالي هيصير فيه تداخل بين الأمونيا اللي
+
+148
+00:12:16,120 --> 00:12:20,720
+نتجت عن التفاعل والأمونيا اللي أصلًا جاية من
+
+149
+00:12:20,720 --> 00:12:25,900
+الـ anticoagulant، الأمونيوم heparin، تمام؟ عشان هيك
+
+150
+00:12:25,900 --> 00:12:30,840
+ممنوع بتاتًا الـ ammonium heparin كـ anticoagulant.
+
+151
+00:12:30,840 --> 00:12:38,740
+تخزين العينة، السيرم والبلازما، سبعة أيام في الثلاجة
+
+152
+00:12:38,740 --> 00:12:43,200
+وعند درجة حرارة الغرفة، وثلاثة أشهر في الفريزر.
+
+153
+00:12:46,730 --> 00:12:50,450
+Urine should be diluted 1:100. لازم أخفف
+
+154
+00:12:50,450 --> 00:12:55,010
+عينة الـ urine اللي بدي أفحص فيها الكرياتينين، واحد
+
+155
+00:12:55,010 --> 00:13:00,250
+إلى مئة. Bacterial contamination has been found to
+
+156
+00:13:00,250 --> 00:13:04,950
+falsely lower creatinine values measured using the
+
+157
+00:13:04,950 --> 00:13:10,950
+Jaffe reaction. Jaffe reaction، هذه برضه طريقة أخرى من
+
+158
+00:13:10,950 --> 00:13:15,790
+خلالها إحنا بنفحص تركيز الكرياتينين. برضه في فحص
+
+159
+00:13:15,790 --> 00:13:20,630
+الكرياتينين زي ما حكينا في اليوريا، إحنا بنخاف كمان
+
+160
+00:13:20,630 --> 00:13:24,210
+هنا من الـ bacterial contamination. هناك في اليوريا
+
+161
+00:13:24,210 --> 00:13:28,890
+حكينا البكتيريا بتفرز urease، بيكسر اليوريا، وبالتالي
+
+162
+00:13:28,890 --> 00:13:34,310
+العينة بتخرب. هنا كذلك البكتيريا بتفرز مواد
+
+163
+00:13:34,310 --> 00:13:40,630
+هذه المواد بتقلل من تركيز الكرياتينين بشكل خاطئ في
+
+164
+00:13:40,630 --> 00:13:46,300
+العينة. The mechanism of this interference appears
+
+165
+00:13:46,300 --> 00:13:50,560
+to be bacterial production of substances that
+
+166
+00:13:50,560 --> 00:13:54,540
+retard the rate of the Jaffe reaction. بتحكي لي هنا
+
+167
+00:13:54,540 --> 00:14:00,100
+البكتيريا بتفرز مواد، هذه المواد بشكل خاطئ بتقلل
+
+168
+00:14:00,100 --> 00:14:05,180
+من تركيز الكرياتينين اللي موجود في العينة، خاصة لو
+
+169
+00:14:05,180 --> 00:14:10,400
+استخدمت طريقة الـ Jaffe reaction. إذًا لازم أجنب الـ
+
+170
+00:14:10,400 --> 00:14:14,960
+bacterial contamination، خاصة كمان لما أشتغل فحص
+
+171
+00:14:14,960 --> 00:14:18,240
+الكرياتينين في اليورين وفي الكرياتينين، ممنوع الـ
+
+172
+00:14:18,240 --> 00:14:19,800
+bacterial contamination.
+
+173
+00:14:21,990 --> 00:14:25,550
+الـ analytical methods، الطرق التحليلية لفحص
+
+174
+00:14:25,550 --> 00:14:30,090
+الكرياتينين. أول طريقة هي الـ Jaffe reaction، وهذه
+
+175
+00:14:30,090 --> 00:14:35,670
+الطريقة اللي كثيرًا يعني بتعتمدها وبتستخدمها. Most
+
+176
+00:14:
+
+223
+00:18:40,710 --> 00:18:45,650
+الـ PEP هتتحول لبيروفيت، البيروفيت مع الـ NADH
+
+224
+00:18:45,650 --> 00:18:50,630
+و الـ H+ هيعطيني لاكتات و NAD+ في وجود اللاكتات هيدروجينيز
+
+225
+00:18:50,630 --> 00:18:54,810
+هيدروجينيز طبعا يا جماعة، هنا امتصاص الكرياتينين
+
+226
+00:18:54,990 --> 00:19:00,450
+هيكون على الـ UV عند 340، لأنه حكيت لكم لو كانت
+
+227
+00:19:00,450 --> 00:19:05,290
+نهاية التفاعل NADH لـ NAD أو العكس من NAD لـ NADH
+
+228
+00:19:05,290 --> 00:19:10,830
+يعني امتصاص المركب هيكون في منطقة الـ UV هذه
+
+229
+00:19:10,830 --> 00:19:15,490
+الطريقة الكتاتنا ما بنستخدمها، تمام؟ الطرق المتوفرة
+
+230
+00:19:15,490 --> 00:19:21,310
+عندنا في الجامعة هي الـ Jaffe Method، مبدأ شغلنا
+
+231
+00:19:21,640 --> 00:19:26,840
+طريقتنا في الكرياتينين، حكينا كاينتك جاف ميثود
+
+232
+00:19:26,840 --> 00:19:30,360
+طريقة الجاف ميثود مش الكولوري مترية، مش اللي
+
+233
+00:19:30,360 --> 00:19:35,800
+بتعتمد على شدة اللون، إنما هي الكاينتك، نشوف مع
+
+234
+00:19:35,800 --> 00:19:39,780
+بعض الكرياتينين بيكون موجود في البلازما أو السيروم
+
+235
+00:19:39,780 --> 00:19:43,840
+هيتفاعل مع مادة الصوديوم بيكربونات أو البيكرِيك
+
+236
+00:19:43,840 --> 00:19:48,310
+أسيد اللي موجود في الـ Reagent، محصلة التفاعل إعطاء
+
+237
+00:19:48,310 --> 00:19:52,470
+مركب اسمه "Creatinine-Picrate Complex" أنا
+
+238
+00:19:52,470 --> 00:19:58,170
+بما أن طريقتي كاينتك، يعني ما بقيس أنا شدة لون إنما
+
+239
+00:19:58,170 --> 00:20:07,930
+إحنا بنقيس التغير في معدل امتصاص الكرياتينين عند
+
+240
+00:20:07,930 --> 00:20:16,070
+وقت معين، إذن إحنا بدنا نقيس التغير في معدل الامتصاص
+
+241
+00:20:16,070 --> 00:20:23,710
+لمادة الكرياتينين عند وقت معين، وهذا التغير اللي
+
+242
+00:20:23,710 --> 00:20:29,730
+بيصير في الامتصاص هيتناسب تناسبا طرديا مع تركيز
+
+243
+00:20:29,730 --> 00:20:35,890
+الكرياتينين في العينة، الاختلاف في الامتصاص إحنا
+
+244
+00:20:35,890 --> 00:20:43,320
+بدنا نقيسه، التغير في معدل الامتصاص عند وقت معين at
+
+245
+00:20:43,320 --> 00:20:49,460
+a fixed time خلال ما بتتكون الـ Complex، وهذا بيتناسب
+
+246
+00:20:49,460 --> 00:20:54,380
+تناسبا طرديا مع تركيز الكرياتينين في العينة، هنفهم
+
+247
+00:20:54,380 --> 00:20:57,420
+أكتر المبدأ في الـ procedure، تمام؟
+
+248
+00:21:00,630 --> 00:21:04,830
+الـ procedure ياريت تركزوا مع بعض لأنها شوية مختلفة
+
+249
+00:21:04,830 --> 00:21:11,290
+بما إنها طريقة كاينتك، ما بتعتمد على شدة اللون، أول
+
+250
+00:21:11,290 --> 00:21:16,290
+شيء بتحضري الـ working reagent، يعني  كت الكرياتينين
+
+251
+00:21:16,290 --> 00:21:20,930
+يا جماعة بيكون فيه two reagents، reagent واحد و
+
+252
+00:21:20,930 --> 00:21:26,420
+reagent اتنين، بنخلط الـ two reagents مع بعض، مثلا
+
+253
+00:21:26,420 --> 00:21:32,660
+بتحطي 4 parts من reagent A مع 1 part من reagent B
+
+254
+00:21:32,660 --> 00:21:37,280
+ما بدي أكوا تعرفوا قد ايش احط من هذا وقد ايش احط من هذا بس
+
+255
+00:21:37,280 --> 00:21:41,440
+الفكرة working reagent أنه أنا بخلط two reagents
+
+256
+00:21:41,440 --> 00:21:46,880
+مع بعضهم البعض، وهذا الخليط صار اسمه working reagent
+
+257
+00:21:46,880 --> 00:21:51,340
+ضروري وأنا بحطه في الـ water bath بدفيه يعني قبل
+
+258
+00:21:51,340 --> 00:21:58,160
+ما استخدمه لازم أدفيه، بعد هيك بتروحي تجيبي الكيوفية
+
+259
+00:21:58,160 --> 00:22:03,900
+فاضية زي ما هي و بتحطيها جوا الجهاز، جوا الـ
+
+260
+00:22:03,900 --> 00:22:09,220
+Spectrophotometer، تمام؟ بتروحي تاخدي 1 ml من الـ
+
+261
+00:22:09,220 --> 00:22:13,280
+working reagent اللي حضرتيه وبتحطيه في الكيوفية
+
+262
+00:22:13,280 --> 00:22:17,440
+اللي موجودة في الجهاز، بتحطي 1 ml من الـ working
+
+263
+00:22:17,440 --> 00:22:21,740
+reagent في الكيوفية اللي موجودة في الجهاز وبتصفري
+
+264
+00:22:21,740 --> 00:22:25,930
+عليه، إذا صار عندي working reagent موجود في الكيوفية
+
+265
+00:22:25,930 --> 00:22:31,250
+في الجهاز بصفر عليه، بعدين بتفتحي الجهاز، بتروحي تجيبي
+
+266
+00:22:31,250 --> 00:22:35,930
+علبة الـ standard اللي بتكون موجودة في الـ kit، تاخدي
+
+267
+00:22:35,930 --> 00:22:41,450
+منها 100 microliter، وهذه الـ 100 microliter من الـ
+
+268
+00:22:41,450 --> 00:22:47,610
+standard بتحطيها فوق الـ 1 ml، تمام؟ أول ما تحطي الـ
+
+269
+00:22:47,610 --> 00:22:53,240
+100 microliter فوق الـ 1 ml، بتشغلي الـ stopwatch
+
+270
+00:22:53,240 --> 00:22:58,940
+بتشغلي الساعة، على طول بتعملي mix وبتسكري الجهاز، أول
+
+271
+00:22:58,940 --> 00:23:03,300
+ما يصير عندك تلاتين seconds على الساعة، تاخدي
+
+272
+00:23:03,300 --> 00:23:08,820
+absorbance رقم واحد، وبتخلي الساعة تضلها تعد لما
+
+273
+00:23:08,820 --> 00:23:14,980
+يصير تسعين seconds، بتاخدي absorbance اتنين، إذا على
+
+274
+00:23:14,980 --> 00:23:20,820
+التلاتين ثانية تاخدي قراءة، وعند التسعين ثانية تاخدي
+
+275
+00:23:20,820 --> 00:23:27,450
+قراءة تانية، إذن عينة الـ Standard صار إلها two
+
+276
+00:23:27,450 --> 00:23:32,910
+absorbances، absorbance one و absorbance two، تطرحي الـ
+
+277
+00:23:32,910 --> 00:23:37,170
+two absorbances من بعض، تطرحي الـ absorbance الثاني
+
+278
+00:23:37,170 --> 00:23:41,510
+من الـ absorbance الأول، بتطلعلك عندك الـ absorbance
+
+279
+00:23:41,510 --> 00:23:46,390
+اللي هتستخدميه في القانون عشان تحسبي تركيز
+
+280
+00:23:46,390 --> 00:23:52,390
+الكرياتينين، ونفس الشيء بنعمل للـ sample، نعيد كمان
+
+281
+00:23:52,390 --> 00:23:58,370
+مرة، بروح أجيب 1 ml من الـ working reagent اللي
+
+282
+00:23:58,370 --> 00:24:02,770
+دفيته في الـ water bath، بحطه في الـ cuvette وبحطه
+
+283
+00:24:02,770 --> 00:24:08,680
+في الجهاز وبصفر عليه، بعتبره كأنه blank، بفتح الجهاز
+
+284
+00:24:08,680 --> 00:24:13,300
+بروحة آخذ 100 ميكرو لتر من الـ patient serum أو
+
+285
+00:24:13,300 --> 00:24:19,040
+البلازما، بحطها فوق الـ working reagent اللي موجود
+
+286
+00:24:19,040 --> 00:24:24,180
+في الجهاز، في الكيوفية، أول ما أحط 100 ميكرو لتر من
+
+287
+00:24:24,180 --> 00:24:29,260
+الـ serum start stopwatch، شغل الساعة بسرعة، اعمل mix
+
+288
+00:24:29,260 --> 00:24:36,150
+سريع، وسكر الجهاز، لما بيصير عندك على الساعة تلاتين
+
+289
+00:24:36,150 --> 00:24:40,510
+ثانية بتاخدي قراءة أولى، absorbance واحد، ولما
+
+290
+00:24:40,510 --> 00:24:45,070
+بتصير عندك الساعة تسعين ثانية بتاخدي absorbance
+
+291
+00:24:45,070 --> 00:24:49,790
+رقم اتنين، وهيك الـ reaction بيخلص، تمسك الكيوفية و
+
+292
+00:24:49,790 --> 00:24:54,600
+بترميها، صار عندك 2 absorbance للـ sample تبع
+
+293
+00:24:54,600 --> 00:24:59,980
+المريض، تطرحي absorbance 2 ناقص absorbance 1، لـ
+
+294
+00:24:59,980 --> 00:25:03,220
+absorbance الثاني بتطرحيه من الأول، بتطلع لك الـ
+
+295
+00:25:03,220 --> 00:25:07,120
+absorbance اللي هتستخدميه في القانون، تيجي على
+
+296
+00:25:07,120 --> 00:25:12,220
+بير لامبرت، طبقي الـ concentration للـ sample بيساوي الـ
+
+297
+00:25:12,220 --> 00:25:16,880
+absorbance للـ sample جبته على الـ absorbance للـ
+
+298
+00:25:16,880 --> 00:25:20,910
+standard جبته، ضرب الـ Concentration للـ Standard
+
+299
+00:25:20,910 --> 00:25:24,430
+على علبة الـ Standard بتشوفي تركيز الكرياتينين
+
+300
+00:25:24,430 --> 00:25:30,690
+وبالتالي بتطبيق بير لامبرت تحصلي على تركيز الكرياتينين
+
+301
+00:25:30,690 --> 00:25:35,870
+في الدم، واضح؟ والجهاز بتضبطي الـ wavelengths تبعته
+
+302
+00:25:35,870 --> 00:25:38,430
+على 500 نانومتر
+
+303
+00:25:41,040 --> 00:25:46,000
+إذن لما تحسبي absorbance واحد و absorbance اتنين
+
+304
+00:25:46,000 --> 00:25:50,540
+يعني two absorbances و تطرحيهم من بعض، هذه طريقة
+
+305
+00:25:50,540 --> 00:25:57,620
+بنسميها kinetic، أنه أنا بحسب التغير في معدل
+
+306
+00:25:57,620 --> 00:26:03,900
+الامتصاص، تمام؟ التغير في الـ absorbance، وهذا التغير
+
+307
+00:26:03,900 --> 00:26:08,960
+في الـ Absorbance هو اللي بيتناسب مع تركيز
+
+308
+00:26:08,960 --> 00:26:13,900
+الكرياتينين في العينة، يعني مبدأ شغلنا مش
+
+309
+00:26:13,900 --> 00:26:18,120
+كولوري متري، ما بيعتمد على شدة اللون، إنما بيعتمد
+
+310
+00:26:18,120 --> 00:26:25,740
+على التغير في معدل الامتصاص للكرياتينين، تمام؟ الـ
+
+311
+00:26:25,740 --> 00:26:31,110
+Normal Range للكرياتينين عند البالغين، للـ Female و
+
+312
+00:26:31,110 --> 00:26:37,970
+Male و للـ Child عند الأطفال، عند الإناث من 0.6 لـ 1.1
+
+313
+00:26:37,970 --> 00:26:42,670
+ميلي جرام per deciliter، شايفين كده تركيزه
+
+314
+00:26:42,670 --> 00:26:48,410
+الكرياتينين؟ كده قليل جدا في الدم، عند الذكور من 0.9
+
+315
+00:26:48,410 --> 00:26:53,530
+لـ 1.3، أكتر شوية لأن حجم العضلات عندهم أكبر
+
+316
+00:26:53,530 --> 00:26:57,880
+وبالتالي كمية الكرياتينين عندهم أعلى، أما للـ Child
+
+317
+00:26:57,880 --> 00:27:01,900
+العكس، عضلاتهم صغيرة، كمية الكرياتينين عندهم بتكون
+
+318
+00:27:01,900 --> 00:27:07,300
+قليلة، من 0.3 لـ 0.7، الوحدة بالـ milligram per
+
+319
+00:27:07,300 --> 00:27:15,680
+deciliter، بين الأقواس عند الإناث 53 لـ 97، هذا الـ
+
+320
+00:27:15,680 --> 00:27:20,500
+normal range، ولكن الوحدة هنا بالـ micromole per
+
+321
+00:27:20,500 --> 00:27:26,390
+liter، لكن حقيقة إحنا بنستخدم الوحدة الشائعة
+
+322
+00:27:26,390 --> 00:27:30,310
+والدارجة عندنا الـ milligram per deciliter، فاللي
+
+323
+00:27:30,310 --> 00:27:34,430
+بين الأقواس هذا الـ normal range، ولكن الوحدة
+
+324
+00:27:34,430 --> 00:27:39,110
+بالـ micromole per liter، هذه طريقة الـ Jaffe Method، أما
+
+325
+00:27:39,110 --> 00:27:44,070
+الـ Enzymatic method لها normal range خاص فيها، نفس
+
+326
+00:27:44,070 --> 00:27:45,390
+الكلام، تمام؟
+
+327
+00:27:49,950 --> 00:27:54,270
+يعني كل طريقة بيكون إلها Normal Range خاص فيها
+
+328
+00:27:54,270 --> 00:27:59,950
+اللي بين الأقواس النتيجة بالـ micro mole per liter
+
+329
+00:27:59,950 --> 00:28:03,770
+أما اللي من غير أقواس بالـ milligram per deciliter
+
+330
+00:28:03,770 --> 00:28:07,550
+والوحدة الشائعة للبولي يوريا والكرياتينين و الـ uric acid
+
+331
+00:28:07,550 --> 00:28:10,130
+بالـ milligram per deciliter
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/0ya7Xzqlzfg_raw.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/0ya7Xzqlzfg_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..fdeb2745cacb1e9384273474249008ec434b0a4e
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/0ya7Xzqlzfg_raw.srt
@@ -0,0 +1,1324 @@
+1
+00:00:00,890 --> 00:00:05,870
+كرياتينين المادة الأخرى اللي بتشيك على وظائف الكلة
+
+2
+00:00:05,870 --> 00:00:09,810
+is a non-protein nitrogen waste product formed in
+
+3
+00:00:09,810 --> 00:00:14,210
+muscle مادة الكرياتينين هي إحدى المواد اللي بتحتوي
+
+4
+00:00:14,210 --> 00:00:19,230
+على نيتروجين ولا تعتبر من ضمن البروتينات وهي فضلات
+
+5
+00:00:19,230 --> 00:00:23,470
+بتتكون في العضلات ولازم الجسم يتخلص من هذه الفضلات
+
+6
+00:00:23,470 --> 00:00:30,500
+ويخرجها عن طريق ال urine كيف؟ العضلةفي حالة الـ
+
+7
+00:00:30,500 --> 00:00:35,820
+Contraction، الإنقباضات، وفي حالة الشغل، ولمّا
+
+8
+00:00:35,820 --> 00:00:39,840
+يكون بدها طاقة، جواة العضلات في مادة اسمها
+
+9
+00:00:39,840 --> 00:00:45,220
+الكرياتين. هذه المادة بتستخدمها العضلة من أجل
+
+10
+00:00:45,220 --> 00:00:50,320
+الحصول على الطاقة، ومن أجل أداء العمليات الحيوية
+
+11
+00:00:50,320 --> 00:00:54,950
+الخاصة فيها.لكن في حال صار في عندي Relaxation
+
+12
+00:00:54,950 --> 00:01:00,030
+استرخاء في العضلة هتبطل تستخدم مادة الكرياتين
+
+13
+00:01:00,030 --> 00:01:04,850
+فاللي بيصير في حالة الـ Relaxation للعضلة بيصير
+
+14
+00:01:04,850 --> 00:01:11,230
+عندي Degradation تكسير لمادة الكرياتين وبتتحول هذه
+
+15
+00:01:11,230 --> 00:01:16,610
+المادة إلى مادة أخرى اسمها الكرياتينين اللي احنا
+
+16
+00:01:16,610 --> 00:01:22,120
+بدنا ياه، اذا الكرياتينينالمادة تبعتنا هي waste
+
+17
+00:01:22,120 --> 00:01:28,020
+product فضلات جاية من وين جاية من تكسير مادة الـ
+
+18
+00:01:28,020 --> 00:01:32,500
+creatine في حالة الـ relaxation للعضلة
+
+19
+00:01:33,820 --> 00:01:40,600
+إذاً الكرياتين ممكن يتم منه نزع ميّه وبتحول
+
+20
+00:01:40,600 --> 00:01:45,860
+لكرياتينين أو الكرياتين ممكن يكون مربوط بـ
+
+21
+00:01:45,860 --> 00:01:49,400
+Phosphate Group لو نزعتي منه الـ Phosphate Group
+
+22
+00:01:49,400 --> 00:01:54,400
+بتحول لكرياتينين وهذه العملية بتصير في حالة الـ
+
+23
+00:01:54,400 --> 00:01:59,200
+Relaxation لما العضلة ما بدها مادة الكرياتين فيها
+
+24
+00:01:59,200 --> 00:02:03,100
+فبتم تحويل الكرياتين لكرياتينين
+
+25
+00:02:04,590 --> 00:02:08,470
+طبعا هذه المعلومات فقط يعني لازم تعرفوا
+
+26
+00:02:08,470 --> 00:02:13,730
+الكرياتينين من وين جاي للمعرفةfiltered by kidney
+
+27
+00:02:13,730 --> 00:02:17,890
+and excreted in the urine هذا الكرياتينين ممنوع
+
+28
+00:02:17,890 --> 00:02:22,710
+يظل في الدم لأنه فضلة بتكون في العضلة بعد هيك بخرش
+
+29
+00:02:22,710 --> 00:02:28,390
+على الدم فلازم الجسم يتخلص منه فيروح الكرياتينين
+
+30
+00:02:28,390 --> 00:02:33,570
+على الكلا والكلا بتعمله excretion تخرجه مع ال
+
+31
+00:02:33,570 --> 00:02:40,030
+urineالكرياتينين يفلتر بسهولة إلى الـ agglomerular
+
+32
+00:02:40,030 --> 00:02:46,150
+تفلتر وليس مستعمل بسبب الـ tubule حقيقة يا جماعة
+
+33
+00:02:46,150 --> 00:02:52,840
+إن كل الكرياتينين بيصير له execution مع اليورينإذن
+
+34
+00:02:52,840 --> 00:02:57,960
+الكرياتينين مادة فضلات waste product بيصيرلها
+
+35
+00:02:57,960 --> 00:03:03,560
+فلترة عن طريق الكلة وبتخرج مع ال urine كلها إلا
+
+36
+00:03:03,560 --> 00:03:09,140
+جزء بسيط جدا جدا يعني أعشار من الكرياتينين بيضلوا
+
+37
+00:03:09,140 --> 00:03:14,100
+في الدميعني جزء بسيط بيصيرله Reabsorption بتم
+
+38
+00:03:14,100 --> 00:03:18,480
+إعادة انتصاصه للدم بسيط جدا مش زي الـUreal
+
+39
+00:03:18,480 --> 00:03:22,520
+الـUreal حكينا 40% بيصيرله إعادة انتصاص لأ
+
+40
+00:03:22,520 --> 00:03:26,160
+الكرياتينين كله بيطلع مع ال urine برا الجسم
+
+41
+00:03:26,160 --> 00:03:31,790
+باستثناء جزء ضئيل جدا بيضله في الدمThe amount
+
+42
+00:03:31,790 --> 00:03:36,390
+excreted daily is a function of muscle mass and is
+
+43
+00:03:36,390 --> 00:03:40,710
+not affected too much by diet تركيز الكرياتينين يا
+
+44
+00:03:40,710 --> 00:03:47,040
+جماعة ما بتأثر بالأكل مش زي اليوليا تمام؟تركيز
+
+45
+00:03:47,040 --> 00:03:51,900
+الكرياتينين بيعتمد على الـ muscle mass حجم العضلة
+
+46
+00:03:51,900 --> 00:03:57,100
+هلجيت الرجال عندهم تركيز الكرياتينين في الدم أعلى
+
+47
+00:03:57,100 --> 00:04:02,280
+من النساء، ليش؟ لأن الرجال ال muscle حجم العضلة
+
+48
+00:04:02,280 --> 00:04:08,200
+عندهم أكبر وبالتالي بتكون عندهم فضلات أكتر، بتكون
+
+49
+00:04:08,200 --> 00:04:14,700
+عندهم كرياتينين أكتر، تمام؟فالكرياتينين تركيزوا
+
+50
+00:04:14,700 --> 00:04:18,960
+عند الرجال أعلى من النساء بإيش بسيط حسب ال muscle
+
+51
+00:04:18,960 --> 00:04:23,020
+mass طيب عند الأطفال حجم العضلات كتير صغيرة
+
+52
+00:04:23,020 --> 00:04:28,040
+وبالتالي تركيز الكرياتينين في الدنب عندهم بيكون
+
+53
+00:04:28,040 --> 00:04:33,580
+قليل جدا جدا حسب ال muscle mass حسب حجم العضلة
+
+54
+00:04:33,580 --> 00:04:34,380
+تمام؟
+
+55
+00:04:36,820 --> 00:04:40,420
+الـ Clinical Significance أهمية الفحص «Elevated
+
+56
+00:04:40,420 --> 00:04:44,200
+Creatinine» is found with abnormal renal function
+
+57
+00:04:44,200 --> 00:04:48,180
+الناس اللي عندها مشكلة فيه الكلة معناه الكلة مش
+
+58
+00:04:48,180 --> 00:04:52,300
+هتقدر تعمل فلترة تمام؟ وبالتالي مش هتطلع
+
+59
+00:04:52,300 --> 00:04:55,960
+الكرياتينين مع الـ urine فهيضل الكرياتينين محجوز
+
+60
+00:04:55,960 --> 00:05:01,940
+في الدم ويزيد تركيزه هذا الاختصار اختصار لـ
+
+61
+00:05:01,940 --> 00:05:08,650
+Glomerulus filtration rateمعدل الفلترة تمام لـ
+
+62
+00:05:08,650 --> 00:05:12,630
+Glomerulus هذا العضو اللي موجود في الكلة موجود في
+
+63
+00:05:12,630 --> 00:05:16,890
+تركيبة الكلة المسئول عن الفلترة اللي بيفلتر الدم
+
+64
+00:05:16,890 --> 00:05:21,470
+وبطلع المكونات اللي بدنا شياها مع ال urine الفضلات
+
+65
+00:05:21,470 --> 00:05:27,490
+وبرجع الشغلات المهمة للدمtherefore any condition
+
+66
+00:05:27,490 --> 00:05:31,250
+that reduces the glomerulus filtration rate will
+
+67
+00:05:31,250 --> 00:05:37,770
+result in أي حالة تؤدي إلى نقص في معدل الفلترة
+
+68
+00:05:37,770 --> 00:05:43,490
+يعني لو الكلة انصابت بمشكلة هذه المشكلة أثرت على
+
+69
+00:05:43,490 --> 00:05:48,630
+الكلة وبالتالي الكلة بطلت تقدر تفلتر إذا هذه ال
+
+70
+00:05:48,630 --> 00:05:53,230
+condition جللت من معدل الفلترة من ال glomerulus
+
+71
+00:05:53,230 --> 00:05:57,860
+filtration rateلما الـ killer تصير قدرتها على
+
+72
+00:05:57,860 --> 00:06:04,240
+الفلترة ضعيفة معناها مش هتقدر تطلع الكرياتينين مع
+
+73
+00:06:04,240 --> 00:06:07,800
+الـ urine مش هتطلعوا برا الجسم و هيضلوا محجوز في
+
+74
+00:06:07,800 --> 00:06:12,940
+الدم و ال result ان إيش هيصير a less excretion
+
+75
+00:06:12,940 --> 00:06:18,020
+from the body كمية الكرياتينين اللي هتخرج مع ال
+
+76
+00:06:18,020 --> 00:06:23,030
+urine هتكون قليلةwith a consequent rise in the
+
+77
+00:06:23,030 --> 00:06:25,990
+concentration of creatinine in the blood إذا
+
+78
+00:06:25,990 --> 00:06:29,550
+الكرياتينين كميته اللي بتطلع برا الجسم قليلة، وين
+
+79
+00:06:29,550 --> 00:06:33,430
+هيروح الكرياتينين؟ هيظلوا محجوز في الدم ويزيد
+
+80
+00:06:33,430 --> 00:06:39,450
+تركيزه في الدم، تمام؟إذن أي حالة مرضية تؤثر على
+
+81
+00:06:39,450 --> 00:06:44,770
+الكيلة وبالتالي تقلل من معدل فالترة الكيلة هيؤدي
+
+82
+00:06:44,770 --> 00:06:49,510
+ذلك إلى هجذ الكرياتينين في الدم ومنع خروجه مع
+
+83
+00:06:49,510 --> 00:06:53,850
+اليورين الـ Serum karyatinin is a better indicator
+
+84
+00:06:53,850 --> 00:06:58,070
+of renal function than either than ofالـ Blood
+
+85
+00:06:58,070 --> 00:07:01,270
+Urea Nitrogen أو الـ Uric Acid يعتبر فحص
+
+86
+00:07:01,270 --> 00:07:05,970
+الكرياتينين أفضل من فحص اليوريا وأفضل من فحص الـ
+
+87
+00:07:05,970 --> 00:07:10,230
+Uric Acid المادة التالتة، ليش؟ لأن فحص الكرياتينين
+
+88
+00:07:10,230 --> 00:07:16,850
+يعتبر specific للـ Renal Function فحص متخصص للكيلو
+
+89
+00:07:16,850 --> 00:07:24,490
+مشكلها يعني مثلا لو نصبت أنت بمرض معينأو لا،
+
+90
+00:07:24,490 --> 00:07:28,290
+خلّينا نفهمها بشكل آخر اليوريا حكينا بتتأثر
+
+91
+00:07:28,290 --> 00:07:32,570
+بالأكل، بتتأثر بالجفاف، يعني بتزيد في حالات غير
+
+92
+00:07:32,570 --> 00:07:37,030
+مشاكل الكلاة، لكن الكرياتينين فقط يزداد
+
+93
+00:07:37,030 --> 00:07:42,420
+الكرياتينين إذا كان عندي مشكلة في الكلاة، بسلكن أي
+
+94
+00:07:42,420 --> 00:07:47,420
+مشكلة في مكان آخر، في organ آخر، الكرياتينين ما
+
+95
+00:07:47,420 --> 00:07:52,760
+بتأثر الكرياتينين فقط بيتأثر إذا الكلا صار فيها
+
+96
+00:07:52,760 --> 00:07:57,320
+خلل وما بتأثر إذا أكلت أكلات مليانة ولا لأ
+
+97
+00:07:57,320 --> 00:08:02,420
+بالبروتيناتما بيتأثر بالجفاف يعني لو صارش فيه جفاف
+
+98
+00:08:02,420 --> 00:08:07,920
+ما بتأثر تركيزه عشان هو هيك عشان هيك هو أفضل من
+
+99
+00:08:07,920 --> 00:08:14,100
+الفحوصات الأخرى لإنه متخصص لمشاكل الكلة وما بيزيد
+
+100
+00:08:14,100 --> 00:08:21,020
+إلا إذا كان في عندي مشكلة في الكلةطبعاً بيكمل بالـ
+
+101
+00:08:21,020 --> 00:08:24,080
+Clinical significance for renal transplant
+
+102
+00:08:24,080 --> 00:08:28,160
+patients and an increase in serum creatinine of 2
+
+103
+00:08:28,160 --> 00:08:31,420
+milligram per liter has been used as a criterion
+
+104
+00:08:31,420 --> 00:08:35,840
+of establishing rejection هنا كمان فايدة لفحص
+
+105
+00:08:35,840 --> 00:08:40,380
+الكرياتينين الناس اللي بتزرع كيلة طبعا انتوا
+
+106
+00:08:40,380 --> 00:08:44,420
+بتعرفوا الزراعة مشاكلها ال rejectionالرفض تمام وهل
+
+107
+00:08:44,420 --> 00:08:49,000
+الجسم هيقبل العضو المزروع فيه ولا لا؟ هيتهاجم من
+
+108
+00:08:49,000 --> 00:08:52,320
+قبل مناعة الشخص ولا لا؟ طبعا الإنسان اللي بزراع
+
+109
+00:08:52,320 --> 00:08:56,900
+كيله بعد الزراعة لازم أتابعه، بتابعه بأي فحص بفحص
+
+110
+00:08:56,900 --> 00:09:01,300
+الكرياتينين، كل يومين، تلاتة، أربعة، بعمله الفحص
+
+111
+00:09:01,890 --> 00:09:07,430
+وجدت ما أشوف أنه الكرياتينين بدأ يرتفع شويه بفهم
+
+112
+00:09:07,430 --> 00:09:12,550
+أنه ممكن احتمال يصير في عندي rejection هذه الفايدة
+
+113
+00:09:12,550 --> 00:09:16,310
+للفحص فقط هذا اللي بدنا نفهمه أما 2 milligram per
+
+114
+00:09:16,310 --> 00:09:21,270
+liter وزاد وقداش مقدار السيادة مش ضروري للحفظ،
+
+115
+00:09:21,270 --> 00:09:28,400
+تمام؟في الناس الأخرى، تغيير الكرياتينين من 2 ملي
+
+116
+00:09:28,400 --> 00:09:33,930
+جرام على لتر، يمثل 20% تخطيط الروحانيةأيضًا
+
+117
+00:09:33,930 --> 00:09:38,650
+الكرياطينين فحص غير إنه مهم لمتابعة وظائف الكلة
+
+118
+00:09:38,650 --> 00:09:44,010
+ولمتابعة في حالات الزراعة برضه مهم إنه لو
+
+119
+00:09:44,010 --> 00:09:49,910
+الكرياطينين في الجثم اتغير بمعدل 2 milligram per
+
+120
+00:09:49,910 --> 00:09:55,430
+liter يعني ارتفع would represent هذا معناه مؤشر
+
+121
+00:09:55,430 --> 00:10:02,960
+ودليل إنه 20%من الكيلة loss للـ function تبعتها 20
+
+122
+00:10:02,960 --> 00:10:09,380
+% من الكيلة فقدت وظيفتها، تمام؟ يعني لو اتغير
+
+123
+00:10:09,380 --> 00:10:14,600
+الكرياتينين في الدم بمقدار 2 milligram per liter،
+
+124
+00:10:14,600 --> 00:10:22,180
+يعني ارتفع هذا مؤشر إن 20% من عدو الكيلة فقدت
+
+125
+00:10:22,180 --> 00:10:27,240
+وظيفته وفي احتمال في المستقبل يصير في عنا فشل كلوي
+
+126
+00:10:28,710 --> 00:10:35,910
+إذن هنا بيبينلك أهمية الـ Creatinine Test للـ
+
+127
+00:10:35,910 --> 00:10:40,370
+specimen one can analyse serum plasma or diluted
+
+128
+00:10:40,370 --> 00:10:46,090
+urine إذن سيرم بلازمة ال urine برضه ممكن أفحص فيه
+
+129
+00:10:46,090 --> 00:10:48,910
+ال creatinine بس لأن تركيز ال creatinine في ال
+
+130
+00:10:48,910 --> 00:10:53,190
+urine عالي كتير فلازم أخفف العينة قبل ما أستخدمها
+
+131
+00:10:53,190 --> 00:10:57,490
+عشان هي كتبلكم ال diluted urineThe common
+
+132
+00:10:57,490 --> 00:11:01,650
+anticoagulant fluoride and heparin don't cause
+
+133
+00:11:01,650 --> 00:11:06,370
+interference يعني الـ Anticoagulant المسموح فيه
+
+134
+00:11:06,370 --> 00:11:10,910
+لما بدي أفصل لبلازمة إما fluoride أو heparin
+
+135
+00:11:10,910 --> 00:11:15,130
+«though heparin, which can't be formulated as
+
+136
+00:11:15,130 --> 00:11:19,230
+ammonium salt, must be avoided in enzymatic
+
+137
+00:11:19,230 --> 00:11:23,650
+methods that measure ammonia production» بيقوللي
+
+138
+00:11:23,650 --> 00:11:29,540
+إنه الـ ammonium heparinأملاح الـ Ammonium Heparin
+
+139
+00:11:29,540 --> 00:11:34,240
+ممنوعة يعني الـ Ammonium Heparin ممنوع كـ
+
+140
+00:11:34,240 --> 00:11:39,780
+Anticoagulant ليش؟ وخاصة لو طريقة الـ kit هي
+
+141
+00:11:39,780 --> 00:11:44,900
+enzymatic methods طريقة شغل الكرياتينين لو كانت
+
+142
+00:11:44,900 --> 00:11:49,140
+enzymatic methods ممنوعة تستخدمي الـ Ammonium
+
+143
+00:11:49,140 --> 00:11:53,600
+Heparin كـ Anticoagulant لأن بهذه الطريقة في الـ
+
+144
+00:11:53,600 --> 00:11:59,680
+reaction هيكون فيه إنتاج للأمونياتمام؟ طب وإنتي
+
+145
+00:11:59,680 --> 00:12:04,120
+أصلاً الـAnticoagulant فيه أمونيام الأمونيام لو
+
+146
+00:12:04,120 --> 00:12:09,820
+كسرتيها الأمونيام هي NH4 لو كسرتيها هتعطيكي أمونيا
+
+147
+00:12:09,820 --> 00:12:16,120
+NH3 وبالتالي هيصير فيه تداخل بين الأمونيا اللي
+
+148
+00:12:16,120 --> 00:12:20,720
+نتجت عن التفاعل والأمونيا اللي أصلاً جاية من
+
+149
+00:12:20,720 --> 00:12:25,900
+الـAnticoagulant الأمونيام «هيبرين» تمام؟ عشان هيك
+
+150
+00:12:25,900 --> 00:12:30,840
+ممنوع بتاتاًالـ Ammonium Heparin كـ Anti-Coagulant
+
+151
+00:12:30,840 --> 00:12:38,740
+تخزين العيلة السيرم والبلازمة سبع أيام في التلاجة
+
+152
+00:12:38,740 --> 00:12:43,200
+والـ room temperature و تلت شهور بالفريزر
+
+153
+00:12:46,730 --> 00:12:50,450
+Urine should be diluted واحد إلى مية لازم أخفف
+
+154
+00:12:50,450 --> 00:12:55,010
+عينة الـUrine اللي بدي أفحص فيها الكرياتينين واحد
+
+155
+00:12:55,010 --> 00:13:00,250
+إلى مية bacterial contamination has been found to
+
+156
+00:13:00,250 --> 00:13:04,950
+falsely lower كرياتينين values measured using the
+
+157
+00:13:04,950 --> 00:13:10,950
+Jeff reaction Jeff reaction هدي برضه طريقة أخرى من
+
+158
+00:13:10,950 --> 00:13:15,790
+خلالها احنا بنفحص تركيز الكرياتينينبرضه في فحص
+
+159
+00:13:15,790 --> 00:13:20,630
+الكرياتينين زي ما حكينا في اليوريا إحنا بنخاف كمان
+
+160
+00:13:20,630 --> 00:13:24,210
+هنا من الـbacterial contamination هناك في اليوريا
+
+161
+00:13:24,210 --> 00:13:28,890
+حكينا تفرذ البكتيريا يورييز بيكسر اليوريا وبالتالي
+
+162
+00:13:28,890 --> 00:13:34,310
+العينة بتخرب هنا كذلك البكتيريا بيحكينا تفرذ مواد
+
+163
+00:13:34,310 --> 00:13:40,630
+هذه المواد بتقلل من تركيز الكرياتينين بشكل خاطئ في
+
+164
+00:13:40,630 --> 00:13:46,300
+العينةThe mechanism of this interference appears
+
+165
+00:13:46,300 --> 00:13:50,560
+to the bacterial production of substances that
+
+166
+00:13:50,560 --> 00:13:54,540
+retard the rate of the Jeffery action تحكيلي هنا
+
+167
+00:13:54,540 --> 00:14:00,100
+البكتيريا بتفرز مواد، هذه المواد بشكل خاطئ بتقلل
+
+168
+00:14:00,100 --> 00:14:05,180
+من تركيز الكرياتينين اللي موجود في العينة خاصة لو
+
+169
+00:14:05,180 --> 00:14:10,400
+استخدمت طريقة الـJeffery actionإذن لازم أجنب الـ
+
+170
+00:14:10,400 --> 00:14:14,960
+bacterial contamination خاصة كمان لما أشتغل فحص
+
+171
+00:14:14,960 --> 00:14:18,240
+الكرياتينين في اليوريا وفي الكرياتينين ممنوع ال
+
+172
+00:14:18,240 --> 00:14:19,800
+bacterial contamination
+
+173
+00:14:21,990 --> 00:14:25,550
+الـ Analytical Methods الطرق التحليلية لفحص
+
+174
+00:14:25,550 --> 00:14:30,090
+الكرياتينين أول طريقة هي الـ Jaffre Action وهذه
+
+175
+00:14:30,090 --> 00:14:35,670
+الطريقة اللي كتاتنا يعني بتعتمدها و بتستخدمها Most
+
+176
+00:14:35,670 --> 00:14:40,670
+frequently used يعني بتستخدم بشكل شائع Was first
+
+177
+00:14:40,670 --> 00:14:45,750
+described in 1886 تم اكتشاف هذه الطريقة في الـ
+
+178
+00:14:45,750 --> 00:14:52,680
+1886مبدأ الطريقة بكل بساطة الكرياتينين بيكون موجود
+
+179
+00:14:52,680 --> 00:14:57,760
+في البلازمة طبعا الوضع الطبيعي تركيزه قليل جدا جدا
+
+180
+00:14:57,760 --> 00:15:04,000
+موجود في بلازمة الدموعندي Reagent هذا الـ Reagent
+
+181
+00:15:04,000 --> 00:15:07,780
+فيه مادة الـ Bicric Acid مادة حنضية اسمها الـ
+
+182
+00:15:07,780 --> 00:15:13,200
+Bicric Acid والـ Reagent الـ pH تبعته قاعدية إذن
+
+183
+00:15:13,200 --> 00:15:17,600
+الكرياتينين اللي في العينة react with Bicric Acid
+
+184
+00:15:17,600 --> 00:15:22,640
+بتفاعل مع مادة الـ Bicric Acid اللي موجودة في الـ
+
+185
+00:15:22,640 --> 00:15:26,800
+Reagent in alkaline solution في الـ Reagent اللي
+
+186
+00:15:26,800 --> 00:15:33,090
+الـ pH تبعته قاعديةمحصلة التفاعل بيعطيني لون Red
+
+187
+00:15:33,090 --> 00:15:38,470
+Orange Chromogen وهذا اللون اللي بيطلع في الآخر
+
+188
+00:15:38,470 --> 00:15:43,710
+شدته بتتناسب تناسب تردي مع تركيز الكرياتينين اللي
+
+189
+00:15:43,710 --> 00:15:49,290
+موجود في العينة هذه طريقة بسيطة جدا، لكن فيها عيوب
+
+190
+00:15:50,690 --> 00:15:56,590
+إنه جليكوز الـ Keto Acid و الـ Uric Acid ممكن يزيد
+
+191
+00:15:56,590 --> 00:15:59,930
+الكرياتينين الـ concentration measured by the
+
+192
+00:15:59,930 --> 00:16:05,010
+Jaffe reaction الكرياتينين بيسيرله انتصاص تقريبًا
+
+193
+00:16:05,010 --> 00:16:10,210
+على 500 نانومتر هذا الـ wavelength أيضًا إذا
+
+194
+00:16:10,210 --> 00:16:17,420
+بتتذكرواالـ Gelocose و الـ Keto Acid و الـ Uric
+
+195
+00:16:17,420 --> 00:16:22,940
+Acid برضه هذه المواد بيصيرلها انتصاص على نفس الـ
+
+196
+00:16:22,940 --> 00:16:28,300
+wavelength اللي الكرياتينين بيمطس عندهم فلو العينة
+
+197
+00:16:28,300 --> 00:16:32,580
+تبعت المريض كان فيها الـ Gelocose عالي أو الـ Uric
+
+198
+00:16:32,580 --> 00:16:38,240
+Acid عالي أو الـ Keto Acid عالي برضه هيصيرلهم
+
+199
+00:16:38,240 --> 00:16:39,280
+انتصاص
+
+200
+00:16:41,280 --> 00:16:46,320
+وهدول التلت مواد لو كانوا موجودين في عينة المريض
+
+201
+00:16:46,320 --> 00:16:53,100
+بتركيز عالي هيزودوا تركيز الكرياتينين بشكل خاطئ في
+
+202
+00:16:53,100 --> 00:16:59,040
+التفاعل وبالتالي هيطلع الكرياتينين عالي جداً وهذا
+
+203
+00:16:59,040 --> 00:17:04,290
+من سلبيات الطريقةإن لو الـGlucose أو الـUric Acid
+
+204
+00:17:04,290 --> 00:17:07,930
+أو الـKeto Acid كانوا موجودين بتركيز عالي في
+
+205
+00:17:07,930 --> 00:17:12,310
+العينة، هيزودوا تركيز الكرياتينين في العينة بشكل
+
+206
+00:17:12,310 --> 00:17:18,130
+خاطر. عشان هيك، إحنا بنستخدم طريقة الـGefre
+
+207
+00:17:18,130 --> 00:17:22,550
+Action، ولكن مش الـColorimetric، مش اللي بتعتمد
+
+208
+00:17:22,550 --> 00:17:27,490
+على تكوين اللون، إنما هي الـKinetic.اللي إحنا من
+
+209
+00:17:27,490 --> 00:17:32,770
+خلالها بنقيس الـ Rate of change in absorbance is
+
+210
+00:17:32,770 --> 00:17:38,730
+measured بنقيس التغير في معدل الـ absorbance
+
+211
+00:17:38,730 --> 00:17:44,680
+للكرياتينين إذا الطريقة الأخرىالطريقة الأولى هي
+
+212
+00:17:44,680 --> 00:17:48,780
+الـ GeF-Reaction تعتمد بشكل أساسي على اللون
+
+213
+00:17:48,780 --> 00:17:52,580
+Colorometric فيه لها عيوب أما الطريقة التانية
+
+214
+00:17:52,580 --> 00:17:57,760
+الأفضل هي الـ Kinetic GeF-Reaction هذه الطريقة
+
+215
+00:17:57,760 --> 00:18:04,600
+إحنا من خلالها بنقيس التغير فيه معدن الانتصاص
+
+216
+00:18:04,600 --> 00:18:08,060
+لمادة الكرياتينين في العينة
+
+217
+00:18:10,550 --> 00:18:15,390
+طريقة أخرى الـ enzymatic method هذه الطريقة هي
+
+218
+00:18:15,390 --> 00:18:20,250
+المبدأ تبعها انزمات الـ reagent بيكون في انزمات
+
+219
+00:18:20,250 --> 00:18:24,190
+مادة الكرياتينين موجودة في البلازما في وجود
+
+220
+00:18:24,190 --> 00:18:28,930
+الكرياتينيذ بكسر الكرياتينين وبعطيني كرياتين
+
+221
+00:18:28,930 --> 00:18:35,310
+كرياتين مع الـ ATPفي وجود كرياتين كاينيز بعطيني
+
+222
+00:18:35,310 --> 00:18:40,710
+كرياتين فوسفاتو ADP الـ ADP هيتحول لـ ATP ومادة
+
+223
+00:18:40,710 --> 00:18:45,650
+الـ PEP هتتحول ل بيروفيت البيروفيت مع الناد أتش
+
+224
+00:18:45,650 --> 00:18:50,630
+والأتش بلس هيعطيني لاكتات وناد بلس في وجود لاكتات
+
+225
+00:18:50,630 --> 00:18:54,810
+هيدروجينيز طبعا يا جماعة هنا امتصاص الكرياتينين
+
+226
+00:18:54,990 --> 00:19:00,450
+هيكون على الـ UV على 340 لأنه حكيتلكم لو كانت
+
+227
+00:19:00,450 --> 00:19:05,290
+نهاية التفاعل ناد أتش لناد أو العكس من ناد لناد
+
+228
+00:19:05,290 --> 00:19:10,830
+أتش يعني انتصاص المركب هيكون في منطقة الـ UV هذه
+
+229
+00:19:10,830 --> 00:19:15,490
+الطريقة كتاتنا ماب تستخدمها، تمام؟ الكتات المتوفرة
+
+230
+00:19:15,490 --> 00:19:21,310
+عندنا في الجامعة هي الـ Jaf Method مبدأ شغلنا
+
+231
+00:19:21,640 --> 00:19:26,840
+طريقتنا في الكرياتينين حكينا كيناتك جاف ميثود
+
+232
+00:19:26,840 --> 00:19:30,360
+طريقة الجاف ميثود مش الـ Calorimetric مش اللي
+
+233
+00:19:30,360 --> 00:19:35,800
+بتعتمد على شدة اللون إنما هي الـ Kinetic انشوف مع
+
+234
+00:19:35,800 --> 00:19:39,780
+بعض الكرياتينين بيكون موجود في البلازمة أو السيرم
+
+235
+00:19:39,780 --> 00:19:43,840
+هيتفاعل مع مادة الـ Sodium Bicrate أو الـ Bicric
+
+236
+00:19:43,840 --> 00:19:48,310
+Acid اللي موجود في الـ Reagentمحصلة التفاعل اعطاء
+
+237
+00:19:48,310 --> 00:19:52,470
+مُركّب اسمه «Creatinine» بـ «Create Complex» أنا
+
+238
+00:19:52,470 --> 00:19:58,170
+بما أن طريقتي كاينتك يعني ما بقيس أنا شدة لون إنما
+
+239
+00:19:58,170 --> 00:20:07,930
+إحنا بنقيس التغير في معدل انتصاص الكرياتينين عند
+
+240
+00:20:07,930 --> 00:20:16,070
+وقت معينإذن إحنا بدنا نقيس التغير في معدل انتصاص
+
+241
+00:20:16,070 --> 00:20:23,710
+مادة الكرياتينين عند وقت معين وهذا التغير اللي
+
+242
+00:20:23,710 --> 00:20:29,730
+بيصير في الانتصاص هيتناسى التناسب ترضي مع تركيز
+
+243
+00:20:29,730 --> 00:20:35,890
+الكرياتينين في العينة الاختلاف في الانتصاب إحنا
+
+244
+00:20:35,890 --> 00:20:43,320
+بدنا نقيسالتغير في معدل الانتصاص عند وقت معين at
+
+245
+00:20:43,320 --> 00:20:49,460
+fixed time خلال ما بتكوّل الـ Complex وهذا بتناسب
+
+246
+00:20:49,460 --> 00:20:54,380
+تناسب ترضي مع تركيز الكرياطينين في العينة هنفهم
+
+247
+00:20:54,380 --> 00:20:57,420
+أكتر المبدأ في الـ procedure تمام؟
+
+248
+00:21:00,630 --> 00:21:04,830
+الـ procedure ياري تركز مع بعض لإنها شوية مختلفة
+
+249
+00:21:04,830 --> 00:21:11,290
+بما إنها طريقة كائنتك ما بتعتمد على شدة اللون أول
+
+250
+00:21:11,290 --> 00:21:16,290
+إشي بتحضري ال working reagent يعني كت الكرياطينين
+
+251
+00:21:16,290 --> 00:21:20,930
+يا جماعة بيكون فيه two reagent reagent واحد و
+
+252
+00:21:20,930 --> 00:21:26,420
+reagent اتنينبنخلط الـ two reagents مع بعض مثلا
+
+253
+00:21:26,420 --> 00:21:32,660
+بتحطي 4 part من reagent A مع 1 part من reagent B
+
+254
+00:21:32,660 --> 00:21:37,280
+مابديكوا تعرفوا جدش احط من هذا و جدش احط من هذا بس
+
+255
+00:21:37,280 --> 00:21:41,440
+الفكرة working reagent انه انا بخلط two reagents
+
+256
+00:21:41,440 --> 00:21:46,880
+مع بعضهم البعضوهذا الخليط صار اسمه working reagent
+
+257
+00:21:46,880 --> 00:21:51,340
+ضروري وانا حطاه في ال water bath بدفّيه يعني قبل
+
+258
+00:21:51,340 --> 00:21:58,160
+ما استخدمه لازم أدفّيهبعد هيك بتروح تجيبي الكيوفيت
+
+259
+00:21:58,160 --> 00:22:03,900
+فاضية زي ما هي و بتحطيها جواة الجهاز جواة الـ
+
+260
+00:22:03,900 --> 00:22:09,220
+Spectrophotometer تمام؟ بتروحي تاخدي 1 ML من الـ
+
+261
+00:22:09,220 --> 00:22:13,280
+Working Reagent اللي حضرتيه و بتحطيه في الكيوفيت
+
+262
+00:22:13,280 --> 00:22:17,440
+اللي موجودة في الجهاز بتحطي 1 ML من الـ Working
+
+263
+00:22:17,440 --> 00:22:21,740
+Reagent في الكيوفيت اللي موجودة في الجهاز و بتصفري
+
+264
+00:22:21,740 --> 00:22:25,930
+عليهإذا صار عندي working reagent موجود في الكيوفيد
+
+265
+00:22:25,930 --> 00:22:31,250
+في الجهاز بصفر عليه بعدين بتفتح الجهاز بتروح تجيبي
+
+266
+00:22:31,250 --> 00:22:35,930
+علبة ال standard اللي بتكون موجودة في ال kit تاخدي
+
+267
+00:22:35,930 --> 00:22:41,450
+منها 100 microliter و هذه ال 100 microliter من ال
+
+268
+00:22:41,450 --> 00:22:47,610
+standard بتحطيها فوق ال 1 ml تمام؟ أول ما تحطي ال
+
+269
+00:22:47,610 --> 00:22:53,240
+100 microliter فوق ال 1 ml بتشغليلـ stopwatch
+
+270
+00:22:53,240 --> 00:22:58,940
+بتشغّل الساعة عطول بتعملي mix و بتسكري الجهاز أول
+
+271
+00:22:58,940 --> 00:23:03,300
+ما يصير عندك تلاتين seconds ع الساعة تاخدي
+
+272
+00:23:03,300 --> 00:23:08,820
+absorbance رقم واحد وبتخلي الساعة تضلها تعد لما
+
+273
+00:23:08,820 --> 00:23:14,980
+يصير تسعين seconds بتاخدي absorbance اتنين اذا ع
+
+274
+00:23:14,980 --> 00:23:20,820
+التلاتين ثانية تاخدي قراءة وع التسعين ثانية تاخدي
+
+275
+00:23:20,820 --> 00:23:27,450
+قراءةتانيةإذن عينة الـ Standard صار إلها two
+
+276
+00:23:27,450 --> 00:23:32,910
+absorbents absorbents one و absorbents two تطرح ال
+
+277
+00:23:32,910 --> 00:23:37,170
+two absorbents من بعض تطرحي ال absorbents التاني
+
+278
+00:23:37,170 --> 00:23:41,510
+من ال absorbents الأول بتلعلك عندك ال absorbents
+
+279
+00:23:41,510 --> 00:23:46,390
+اللي هتستخدميه في القانون عشان تحسبي تركيز
+
+280
+00:23:46,390 --> 00:23:52,390
+الكرياطينين ونفس الإشي بنعمل لل sample انعيد كمان
+
+281
+00:23:52,390 --> 00:23:58,370
+مرةبروح أجيب واحد قمال من ال working reagent اللي
+
+282
+00:23:58,370 --> 00:24:02,770
+دفيته في ال water bath بحطه في ال cuvette و بحطه
+
+283
+00:24:02,770 --> 00:24:08,680
+في الجهاز و بصفر عليه بعتبره كإنه blankبفتح الجهاز
+
+284
+00:24:08,680 --> 00:24:13,300
+بروح أخد 100 ميكرو لتر من ال patient serum أو
+
+285
+00:24:13,300 --> 00:24:19,040
+البلازمة بحطها فوق ال working reagent اللي موجود
+
+286
+00:24:19,040 --> 00:24:24,180
+في الجهاز في الكيوفيت أول ما حط 100 ميكرو لتر من
+
+287
+00:24:24,180 --> 00:24:29,260
+ال serum start stopwatch شغل الساعة بسرعة اعمل mix
+
+288
+00:24:29,260 --> 00:24:36,150
+سريع وسكر الجهازلما بيصير عندك على الساعة تلاتين
+
+289
+00:24:36,150 --> 00:24:40,510
+ثانية بتاخدي قراءة أولى Absorbance واحد و لما
+
+290
+00:24:40,510 --> 00:24:45,070
+بتصير عندك الساعة تسعين ثانية بتاخدي Absorbance
+
+291
+00:24:45,070 --> 00:24:49,790
+رقم اتنين وهيك ال reaction بيخلص تمسك الكيوفيت و
+
+292
+00:24:49,790 --> 00:24:54,600
+بترميهاصار عندك 2 absorbance للـ sample تبعت
+
+293
+00:24:54,600 --> 00:24:59,980
+المريض تطرحي absorbance 2 ناقص absorbance 1 لـ
+
+294
+00:24:59,980 --> 00:25:03,220
+absorbance التاني بتطرحي من الأول بتطلعلك ال
+
+295
+00:25:03,220 --> 00:25:07,120
+absorbance اللي هتستخدميه في القانون تيجي ع
+
+296
+00:25:07,120 --> 00:25:12,220
+بيرزلور طبقي ال concentration لل sample بيساوي ال
+
+297
+00:25:12,220 --> 00:25:16,880
+absorbance لل sample جبته على ال absorbance لل
+
+298
+00:25:16,880 --> 00:25:20,910
+standard جبتهدرب الـ Concentration للـ Standard
+
+299
+00:25:20,910 --> 00:25:24,430
+على علبة الـ Standard بتشوف تركيز الكرياتينين
+
+300
+00:25:24,430 --> 00:25:30,690
+وبالتالي بتطبيق بيرزلو تحصل على تركيز الكرياتينين
+
+301
+00:25:30,690 --> 00:25:35,870
+في الدم واضح والجهاز بتضبط ال wavelengths تبعته
+
+302
+00:25:35,870 --> 00:25:38,430
+على 500 نانومتر
+
+303
+00:25:41,040 --> 00:25:46,000
+إذن لما تحسب absorbance واحد وabsorbance اتنين
+
+304
+00:25:46,000 --> 00:25:50,540
+يعني two absorbance و تطرحيهم من بعض هذه طريقة
+
+305
+00:25:50,540 --> 00:25:57,620
+بنسميها kinetic انه أنا بحسب التغير في معدل
+
+306
+00:25:57,620 --> 00:26:03,900
+الانتصاص تمام التغير في ال absorbanceوهذا التغير
+
+307
+00:26:03,900 --> 00:26:08,960
+في الـ Absorbance هو اللي بتناسب مع تركيز
+
+308
+00:26:08,960 --> 00:26:13,900
+الكرياتينين في العينة يعني مبدأ شغلنا مش
+
+309
+00:26:13,900 --> 00:26:18,120
+colorimetric ما بيعتمد على شدة اللون إنما بيعتمد
+
+310
+00:26:18,120 --> 00:26:25,740
+على التغير في معدل الإمتصاص للكرياتينين تمام؟ الـ
+
+311
+00:26:25,740 --> 00:26:31,110
+Normal Rangeلأ الكرياطينين عند الـ Adult فمال و
+
+312
+00:26:31,110 --> 00:26:37,970
+Male و لـ Child عند الأطفال عند الفمال من 0.6 ل 1
+
+313
+00:26:37,970 --> 00:26:42,670
+.1 ميلي جرام per deciliter شايفين كده تركيزه
+
+314
+00:26:42,670 --> 00:26:48,410
+الكرياطينين؟ كده قليل جدا في الدم عند المال من 0.9
+
+315
+00:26:48,410 --> 00:26:53,530
+ل 1.3 أكتر شوية لأن حجم العضلات عندهم أكبر
+
+316
+00:26:53,530 --> 00:26:57,880
+وبالتالي كمية الكرياطينين عندهم أعلىأما لـ Child
+
+317
+00:26:57,880 --> 00:27:01,900
+العكس عضلاتهم الصغيرة كمية الكرياتينين عندهم بتكون
+
+318
+00:27:01,900 --> 00:27:07,300
+قليلة من 0.3 ل 0.7 الوحدة بالmilligram per
+
+319
+00:27:07,300 --> 00:27:15,680
+deciliter بين الأقواس عند الفميل 53 ل 97 هذا ال
+
+320
+00:27:15,680 --> 00:27:20,500
+normal range ولكن الوحدة هنا بالmicromole per
+
+321
+00:27:20,500 --> 00:27:26,390
+literلكن حقيقة احنا بنستخدم الوحدة الشائعة
+
+322
+00:27:26,390 --> 00:27:30,310
+والدارجة عندنا الـ milligram per deciliter فاللي
+
+323
+00:27:30,310 --> 00:27:34,430
+بين الأقواس هذا الـnormal range ولكن الوحدة
+
+324
+00:27:34,430 --> 00:27:39,110
+بالmicromole per liter هذه طريقة الـJF method أما
+
+325
+00:27:39,110 --> 00:27:44,070
+الـEnzymatic method لها normal range خاص فيها نفس
+
+326
+00:27:44,070 --> 00:27:45,390
+الكلام تمام؟
+
+327
+00:27:49,950 --> 00:27:54,270
+يعني كل طريقة بيكون إلها Normal Range خاص فيها
+
+328
+00:27:54,270 --> 00:27:59,950
+اللي بين الأقواس النتيجة بال micro mole per liter
+
+329
+00:27:59,950 --> 00:28:03,770
+أما اللي من غير أقواس بال milligram per deciliter
+
+330
+00:28:03,770 --> 00:28:07,550
+والوحدة الشائعة اليوريا والكرياتينين وال uric acid
+
+331
+00:28:07,550 --> 00:28:10,130
+بالmilligram per deciliter
+
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/1cu0B0Ynj-c.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/1cu0B0Ynj-c.srt
new file mode 100644
index 0000000000000000000000000000000000000000..6f01a153b2a3d2462ac1fb35fe2427b253bd631e
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/1cu0B0Ynj-c.srt
@@ -0,0 +1,1370 @@
+1
+00:00:00,340 --> 00:00:04,440
+احنا هيك بنكون بالـ Slides الأولى حسبنا تركيز الـ
+
+2
+00:00:04,440 --> 00:00:08,160
+Total بروتين في بلازمة الدم، هلق بدنا نحسب تركيز
+
+3
+00:00:08,160 --> 00:00:12,260
+الـ albumin نفسه، قد إيش تركيز الـ albumin في بلازمة
+
+4
+00:00:12,260 --> 00:00:15,780
+الدم؟ Albumin is the most abundant circulating
+
+5
+00:00:15,780 --> 00:00:20,240
+plasma protein، 40 ل 60% من الـ total، بيحكي لي أن الـ
+
+6
+00:00:20,240 --> 00:00:25,220
+albumin هو الموجود بوفرة وبكثرة وبأعلى تركيز في
+
+7
+00:00:25,220 --> 00:00:30,510
+البلازمة، ويشكل نصف الـ total بروتين، Playing important
+
+8
+00:00:30,510 --> 00:00:33,750
+roles in the maintenance of the colloid osmotic
+
+9
+00:00:33,750 --> 00:00:37,350
+pressure of blood، يعني يحافظ على الضغط الإسموزي في
+
+10
+00:00:37,350 --> 00:00:42,770
+الدم، in the transport of various ions, acids, and
+
+11
+00:00:42,770 --> 00:00:45,630
+hormones، يعني إيش الوظيفتين؟ بيحافظ على الضغط
+
+12
+00:00:45,630 --> 00:00:50,030
+الإسموزي في الدم، وكمان بيشتغل كـ transporter، كناقل
+
+13
+00:00:50,030 --> 00:00:54,030
+يعني بينقل وبيحمل الـ ions والـ acids والـ hormones
+
+14
+00:00:54,030 --> 00:00:59,100
+من مكان لمكان، بيوصل، تمام؟ لو سألناكوا سؤال: كيف
+
+15
+00:00:59,100 --> 00:01:03,860
+الـ Albumin بيشتغل وبيحافظ على الضغط الإسموزي للدم
+
+16
+00:01:03,860 --> 00:01:09,220
+عن طريق أنه بيمنع خروج السوائل اللي موجودة في
+
+17
+00:01:09,220 --> 00:01:15,380
+الأوعية الدموية إلى خارج أنسجة الجسم، تمام؟
+
+18
+00:01:15,380 --> 00:01:20,280
+وبالتالي، لو شخص عنده نقص في هذا البروتين، هتلاحظي
+
+19
+00:01:20,280 --> 00:01:26,730
+أنه انتفخ، صار عنده إدمة، تمام؟ ليش؟ انتفخ لأنه نقص
+
+20
+00:01:26,730 --> 00:01:33,630
+الـ albumin، وبالتالي حيصير في خروج للسوائل من الأوعية
+
+21
+00:01:33,630 --> 00:01:37,470
+الدموية إلى أنسجة الجسم، وبالتالي حيصير في عنده
+
+22
+00:01:37,470 --> 00:01:43,320
+انتفاخات، حيصير عنده ماء كثير في جسمه، تمام؟ إذن
+
+23
+00:01:43,320 --> 00:01:47,000
+بيحافظ على الضغط الإسموزي من خلال أنه بيمنع خروج
+
+24
+00:01:47,000 --> 00:01:52,220
+السوائل من الأوعية الدموية إلى أنسجة الجسم، وبيشتغل
+
+25
+00:01:52,220 --> 00:01:56,020
+كناقل، it is a globular protein، نوعه globular
+
+26
+00:01:56,020 --> 00:01:59,330
+protein، with a molecular weight of approximately 66
+
+27
+00:01:59,330 --> 00:02:03,370
+ألف دالتون، مش مشكلة نعرف حجم البروتين، and is
+
+28
+00:02:03,370 --> 00:02:07,510
+unique among major plasma proteins in containing
+
+29
+00:02:07,510 --> 00:02:11,230
+no carbohydrate، يعني هو الـ major بروتين اللي
+
+30
+00:02:11,230 --> 00:02:15,810
+موجود في الـ plasma، وله relatively low content
+
+31
+00:02:15,810 --> 00:02:19,750
+of tryptophan، الألبومين عبارة عن سلسلة من الأحماض
+
+32
+00:02:19,750 --> 00:02:24,270
+الأمينية، الـ tryptophan هو عبارة عن حمض أميني،
+
+33
+00:02:24,270 --> 00:02:29,430
+لكن الألبومين لا يعني بيحتوي على tryptophan
+
+34
+00:02:29,430 --> 00:02:32,890
+على هذا الحمض الأميني، ولكن بـ low concentration،
+
+35
+00:02:32,890 --> 00:02:41,270
+بكميات قليلة، And is an anion at pH 7.4، يعني هذا
+
+36
+00:02:41,270 --> 00:02:47,490
+البروتين يحمل شحنة سالبة لما يكون الـ pH تبع الدم
+
+37
+00:02:47,490 --> 00:02:53,050
+neutral، متعادل 7.4، وهذا الطبيعي، إن الـ pH تبع الدم
+
+38
+00:02:53,050 --> 00:02:56,270
+عند الإنسان الطبيعي neutral، وبالتالي الألبومين في
+
+39
+00:02:56,270 --> 00:02:59,590
+هذا الوقت بيحمل شحنة سالبة، These properties
+
+40
+00:02:59,590 --> 00:03:03,190
+have been exploited in the estimation of albumin
+
+41
+00:03:03,190 --> 00:03:06,890
+in body fluids، هذه الصفات والخصائص بتاعة
+
+42
+00:03:06,890 --> 00:03:12,290
+الألبومين مكنتنا من معرفة طرق من أجل حساب تركيز
+
+43
+00:03:12,290 --> 00:03:17,690
+الألبومين في البلازما، الـ Analysis Methods زي ما
+
+44
+00:03:17,690 --> 00:03:20,430
+حكينا، في عندنا طرق كثيرة لحساب الـ Total Protein
+
+45
+00:03:20,430 --> 00:03:24,510
+وبرضه في عندي طرق كثيرة لحساب الـ Albumin، تركيز
+
+46
+00:03:24,510 --> 00:03:28,710
+الـ Albumin في بلازما الدم، أول طريقة: طريقة الترسيب،
+
+47
+00:03:28,710 --> 00:03:31,990
+الـ Precipitation، وهذه طريقة quantitative، يعني
+
+48
+00:03:31,990 --> 00:03:36,990
+بتعطيكي تركيز الـ Albumin بدقة، بتعطيكي قيمة عددية،
+
+49
+00:03:36,990 --> 00:03:43,180
+رقمية، Salt Fractionation، Solvent Fractionation، Acid
+
+50
+00:03:43,180 --> 00:03:46,440
+Fractionation،
+
+51
+00:03:47,170 --> 00:03:52,490
+بيحكي لي إن هذه الطريقة تستخدم ملح أو solvent أو
+
+52
+00:03:52,490 --> 00:03:57,410
+acid، واحد من هدول، إيش هيعمله؟ هيرسبه، يعمل precipitation لـ
+
+53
+00:03:57,410 --> 00:04:02,750
+الـ albumin، للشغل اللي أنا بدي
+
+54
+00:04:02,750 --> 00:04:08,790
+أجيبه، تمام؟ وبناخد هذا البروتين وبتتم قياسه بطريقة
+
+55
+00:04:08,790 --> 00:04:14,400
+معينة، الـ Principle of the Analysis، مبدأ هذه
+
+56
+00:04:14,400 --> 00:04:19,140
+الطريقة: «Changes of net charge of a protein result
+
+57
+00:04:19,140 --> 00:04:23,300
+in precipitation»، مبدأها إنها بتغير شحنات
+
+58
+00:04:23,300 --> 00:04:27,920
+للبروتينات، وبالتالي بترسب البروتين اللي أنت بدك
+
+59
+00:04:27,920 --> 00:04:32,280
+تقيسه، بترسبيه، وبتاخده، وبتقيسه، إذا من اسمها
+
+60
+00:04:32,280 --> 00:04:35,860
+precipitation، فقط هذا اللي بدنا نعرفه عنها، وحتى يا
+
+61
+00:04:35,860 --> 00:04:41,200
+جماعة، بسأل كلكم في هذه الشغلات في الامتحان، بس
+
+62
+00:04:41,200 --> 00:04:46,340
+بطريقتنا المعتمدة، Trip to file content، برضه هذه
+
+63
+00:04:46,340 --> 00:04:52,320
+طريقة quantitative، هذه الطريقة بتعتمد على أن
+
+64
+00:04:52,320 --> 00:04:57,910
+العينة تبعي بيكون فيها الـ Total Protein، كلها الـ
+
+65
+00:04:57,910 --> 00:05:03,010
+albumin والـ globulin، تمام؟ بتروح تجيب Reagent، هذا
+
+66
+00:05:03,010 --> 00:05:07,690
+الـ Reagent بيحتوي على مادة حمضية اسمها الـ
+
+67
+00:05:07,690 --> 00:05:12,970
+glycosic acid، هذه المادة لما بتروح تضيفيها على الـ
+
+68
+00:05:12,970 --> 00:05:20,110
+serum اللي فيه كل الـ Total Protein، هذه المادة يعني
+
+69
+00:05:20,110 --> 00:05:26,090
+لما بتلاقي الـ glycosic acid بتروح بتربط بالـ
+
+70
+00:05:26,090 --> 00:05:30,850
+tryptophan، تمام؟ اتفقنا إن الألبومين ما فيه
+
+71
+00:05:30,850 --> 00:05:35,230
+tryptophan، فيه ولكن بتركيز قليل جداً، مين اللي حكينا
+
+72
+00:05:35,230 --> 00:05:38,730
+فيه tryptophan؟ الـ Globulins، الـ Alpha 1، الـ
+
+73
+00:05:38,730 --> 00:05:43,740
+Alpha 2، الـ Beta والـ Gamma، كل الـ Globulins، تركيب
+
+74
+00:05:43,740 --> 00:05:47,380
+هذه البروتينات فيه tryptophan بكميات كبيرة،
+
+75
+00:05:47,380 --> 00:05:52,480
+فالـ glycosic acid هذه المادة وين فيه tryptophan
+
+76
+00:05:52,480 --> 00:05:58,860
+بتروح تربط فيه، وبالتالي بتعطيني لون، محصلة
+
+77
+00:05:58,860 --> 00:06:03,250
+الـ reaction، اللون الـ purple، معنى الكلام هذه
+
+78
+00:06:03,250 --> 00:06:08,070
+المادة فقط هتتفاعل مع الـ Globulins، مع الـ Alpha 1،
+
+79
+00:06:08,070 --> 00:06:12,810
+والـ Alpha 2، والـ Beta، والـ Gamma، إذا أنا هنا فقط على
+
+80
+00:06:12,810 --> 00:06:17,090
+الـ Spectrophotometer بروح أقرأ اللون اللي طلع
+
+81
+00:06:17,090 --> 00:06:23,420
+والتركيز اللي هحسبه هذا تركيز الـ Globulin، تمام؟ في
+
+82
+00:06:23,420 --> 00:06:28,840
+الآخر، بطبق قانون الـ Total Protein، أنا بكون جايبها
+
+83
+00:06:28,840 --> 00:06:34,260
+من قبل، حسبت الـ Total Protein ككل، تمام؟ بطرحه من
+
+84
+00:06:34,260 --> 00:06:39,600
+تركيز الـ Globulin اللي أنا جبته، والمحصلة
+
+85
+00:06:39,600 --> 00:06:44,000
+هيطلع تركيز الـ albumin، يعني هذه طريقة غير مباشرة،
+
+86
+00:06:44,000 --> 00:06:49,320
+بيجيب مادة الـ glycosic acid، بيضيفها على الـ serum،
+
+87
+00:06:49,320 --> 00:06:53,520
+هذه المادة تربط فقط بالـ tryptophan اللي موجود في
+
+88
+00:06:53,520 --> 00:06:58,660
+الـ globulin، وبالتالي الـ albumin مش هيرتبط، ومش
+
+89
+00:06:58,660 --> 00:07:03,340
+هيصير في reaction معاه، وبالتالي المحصلة اللون، بنجيب
+
+90
+00:07:03,340 --> 00:07:06,920
+هذا اللون على جهاز الـ Spectrophotometer، وبنجيب
+
+91
+00:07:06,920 --> 00:07:10,560
+تركيز الـ Globulins، كلها الـ alpha 1، والـ alpha 2، والـ beta،
+
+92
+00:07:10,560 --> 00:07:14,880
+والـ gamma، فبنطرح تركيز الـ Total Protein ككل من
+
+93
+00:07:14,880 --> 00:07:21,520
+الـ Globulins، هيطلع عندي تركيز الألبومين، تمام؟ طريقة
+
+94
+00:07:21,520 --> 00:07:24,520
+الـ Electrophoresis، برضه طريقة quantitative،
+
+95
+00:07:24,520 --> 00:07:29,700
+حكيت لكم، بنجيب عينة الـ serum وبنعملها loading على
+
+96
+00:07:29,700 --> 00:07:35,740
+supportive media، على جل، على nitrocellulose، تمام؟
+
+97
+00:07:35,740 --> 00:07:41,380
+وبتفصل العينة لخمس bands، الألبومين، الـ alpha 1، الـ alpha
+
+98
+00:07:41,380 --> 00:07:45,690
+2، الـ beta، الـ gamma، بنفصلها خمس bands، هدول
+
+99
+00:07:45,690 --> 00:07:50,150
+الباندات بقدر أنا أحسب تركيز كل باند على حدى، كل
+
+100
+00:07:50,150 --> 00:07:54,830
+بروتين على حدى، بقدر أحسب تركيز الـ Albumin، الـ
+
+101
+00:07:54,830 --> 00:07:58,550
+Principle of Analysis، الألبومين separated from
+
+102
+00:07:58,550 --> 00:08:01,770
+other proteins، بنفصل عن البروتينات الأخرى، in
+
+103
+00:08:01,770 --> 00:08:07,170
+an electrical field، بمجال كهربائي، Present Staining of
+
+104
+00:08:07,170 --> 00:08:10,650
+Albumin Fraction، Multiplied by Total Protein Value،
+
+105
+00:08:10,650 --> 00:08:13,570
+طبعاً يا جماعة، طريقة الـ Electrophoresis بالتفصيل
+
+106
+00:08:13,570 --> 00:08:17,230
+هتاخدوها السنة الرابعة، فصل ثاني، هنحسب تركيز الـ
+
+107
+00:08:17,230 --> 00:08:18,670
+albumin بهذه الطريقة،
+
+108
+00:08:22,000 --> 00:08:27,120
+نكمل بالطرق immunochemical، طرق مناعية كيميائية،
+
+109
+00:08:27,120 --> 00:08:31,260
+يعني بيعتبر الـ albumin كأنه Antigen، مش بروتين تمام، فبيعتبره
+
+110
+00:08:31,260 --> 00:08:35,820
+عبارة عن Antigen، فبروح أجيب Antibody ضد هذا الـ
+
+111
+00:08:35,820 --> 00:08:40,690
+Antigen، فبتكون عندي مُركّب، هذا المُركّب كيف بقيسه؟
+
+112
+00:08:40,690 --> 00:08:44,450
+بما أنه Antibody-Antigen Reaction، يعني بده طرق
+
+113
+00:08:44,450 --> 00:08:48,830
+مناعية، Radial Immunodiffusion، التربيدومتري،
+
+114
+00:08:48,830 --> 00:08:52,470
+النفلومتري، Radio Immunoassay، Enzyme Immunoassay،
+
+115
+00:08:52,470 --> 00:08:56,910
+كلها تقنيات مناعية، هتاخدوها في المناعة عشان تقيسوا
+
+116
+00:08:56,910 --> 00:09:02,280
+تركيز الألبومين، «Dye Binding»، هذه طريقتنا، إن
+
+117
+00:09:02,280 --> 00:09:07,780
+الألبومين بيروح مرتبط بـ dye، بصبغة معينة، وبتكون
+
+118
+00:09:07,780 --> 00:09:11,820
+عندي Complex، وبنقرأ هذا الـ Complex على الـ
+
+119
+00:09:11,820 --> 00:09:17,460
+Spectrophotometer، بكل بساطة، الـ dye هذه منها أنواع
+
+120
+00:09:17,460 --> 00:09:22,440
+كثيرة، إنما بتستخدمي Bromocresol Green أو Bromocresol
+
+121
+00:09:22,440 --> 00:09:26,890
+Purple، هذه أنواع الـ dye، تمام؟ وهذه طريقة
+
+122
+00:09:26,890 --> 00:09:32,490
+quantitative، برضه، هذه طريقة أخرى، نفس المبدأ، dye
+
+123
+00:09:32,490 --> 00:09:40,090
+-binding، ولكنها semi-quantitative، شفتوا،
+
+124
+00:09:40,090 --> 00:09:44,510
+الـ strips في السوائل الخانة التابعة لـ protein، مش
+
+125
+00:09:44,510 --> 00:09:49,050
+بيكون عندنا protein، حكينالكوا يقصد فيها الـ albumin،
+
+126
+00:09:49,050 --> 00:09:55,810
+يعني هل في الـ strip بيقيس هل فيه بروتينات بشكل
+
+127
+00:09:55,810 --> 00:10:00,450
+عام ولا لا، الـ strip تبع الـ urine بيقيس هل فيه
+
+128
+00:10:00,450 --> 00:10:04,290
+albumin في الـ urine ولا لا، مش هل فيه بروتين، هل
+
+129
+00:10:04,290 --> 00:10:07,650
+فيه الـ albumin، نوع من أنواع البروتينات، هل موجود
+
+130
+00:10:07,650 --> 00:10:11,590
+الـ albumin في الـ urine ولا لا، ففي الخانة تبع
+
+131
+00:10:11,590 --> 00:10:16,790
+الـ albumin، بيكون عندنا صبغة اسمها Bromophenol Blue،
+
+132
+00:10:16,790 --> 00:10:24,250
+صح ولا لأ؟ لون المربع، لون المربع في الـ strip
+
+133
+00:10:24,250 --> 00:10:28,530
+بيكون أصفر، إذا  فكرين، لو حطيت الـ strip في عينة
+
+134
+00:10:28,530 --> 00:10:32,910
+الـ urine وكان الـ urine جواته albumin، الألبومين
+
+135
+00:10:32,910 --> 00:10:38,220
+هيتفاعل مع هذه الصبغة، مع الـ Bromophenol Blue، ويحول
+
+136
+00:10:38,220 --> 00:10:43,980
+اللون الأصفر للون أزرق، فاللون الأزرق معناه إنه فيه
+
+137
+00:10:43,980 --> 00:10:49,400
+ألبومين في الـ urine، Bromophenol Blue، الـ strip في الـ
+
+138
+00:10:49,400 --> 00:10:53,640
+strip changed color، بتغير اللون من أصفر لأزرق،
+
+139
+00:10:53,640 --> 00:10:58,820
+معناه في عندنا ألبومين، وهذه الطريقة الشائعة للكشف عن
+
+140
+00:10:58,820 --> 00:11:06,240
+البروتين جوا الـ ألبومين، sorry، هذه طريقة شائعة للكشف
+
+141
+00:11:06,240 --> 00:11:11,840
+عن الـ albumin جوا الـ urine، تمام؟ للكشف عن الـ
+
+142
+00:11:11,840 --> 00:11:16,720
+protein جوا الـ urine، الـ dye binding techniques،
+
+143
+00:11:16,720 --> 00:11:20,720
+هذه الـ method اللي احنا هنستخدمها عشان نحسب تركيز
+
+144
+00:11:20,720 --> 00:11:25,200
+الـ albumin في الـ serum، Serum albumin is most often
+
+145
+00:11:25,200 --> 00:11:29,980
+assayed using dye binding techniques، يعني معظم
+
+146
+00:11:29,980 --> 00:11:34,480
+الطرُق، معظم الكِتَابات بتستخدم طريقة الـ dye binding
+
+147
+00:11:34,480 --> 00:11:40,090
+techniques عشان نحسب الـ albumin، الألبومين prefer bind
+
+148
+00:11:40,090 --> 00:11:45,630
+to anionic dyes that don't attract globulins، قالوا
+
+149
+00:11:45,630 --> 00:11:49,990
+احنا كيف ممكن فكرة الفحص؟ أروح أجيب dye، صبغة، هذه
+
+150
+00:11:49,990 --> 00:11:54,590
+الصبغة الألبومين، الألبومين، الألبومين
+
+151
+00:11:54,590 --> 00:11:59,310
+وجهة ما شافها، هيرتبط فيها، لكن باقي البروتينات الـ
+
+152
+00:11:59,310 --> 00:12:04,230
+globulins الأخرى مش هترتبط مع هذه الـ dye، وبالتالي
+
+153
+00:12:04,230 --> 00:12:09,710
+هيتكون عندي Complex، مركب، عبارة عن ألبومين + dye، تمام؟
+
+154
+00:12:10,600 --> 00:12:15,340
+البرامو كريزول البربل، والبرامو كريزول جرين هما
+
+155
+00:12:15,340 --> 00:12:19,640
+المستخدمين أكثر، هذه أنواع الـ dye اللي بتستخدم
+
+156
+00:12:19,640 --> 00:12:25,380
+بشكل واسع، تمام؟ الـ amount of light absorbed by
+
+157
+00:12:25,380 --> 00:12:28,700
+the albumin-dye complex is proportional to the
+
+158
+00:12:28,700 --> 00:12:32,560
+amount of albumin present، إذا الـ reagent تبعنا
+
+159
+00:12:32,560 --> 00:12:36,880
+هيكون فيه dye، فيه صبغة، والـ serum تبعي هيكون فيه
+
+160
+00:12:36,880 --> 00:12:40,720
+الـ albumin، لما بحط الـ reagent على الـ serum،
+
+161
+00:12:40,720 --> 00:12:44,280
+هتتفاعل الـ dye مع الألبومين، يرتبطوا مع بعض،
+
+162
+00:12:44,280 --> 00:12:49,580
+وهيتكون عندك Complex ملون، شدة اللون هتتناسب
+
+163
+00:12:49,580 --> 00:12:53,740
+طردياً مع تركيز الألبومين في الدم، كل ما كان
+
+164
+00:12:53,740 --> 00:12:58,680
+اللون أغمق، بتوقع يكون تركيز الألبومين أعلى، تمام؟
+
+165
+00:13:00,260 --> 00:13:03,060
+طبعاً يا جماعة، هنا plasma albumin levels، نوع
+
+166
+00:13:03,060 --> 00:13:06,340
+العينة serum أو plasma، although important for
+
+167
+00:13:06,340 --> 00:13:09,620
+management and follow-up، a very little value in
+
+168
+00:13:09,620 --> 00:13:14,400
+clinical diagnosis، بقول لي إنه على الرغم من أهمية
+
+169
+00:13:14,400 --> 00:13:17,860
+معرفة تركيز الـ albumin من أجل متابعة الحالات
+
+170
+00:13:17,860 --> 00:13:23,680
+المرضية، إلا إنه بيعتبر هذا الفحص قيمته مش
+
+171
+00:13:23,680 --> 00:13:28,480
+كبيرة كثير، very little في الحالات التشخيصية
+
+172
+00:13:28,480 --> 00:13:35,210
+السريرية، تمام؟ أو في الحالات التشخيصية مش كتير له
+
+173
+00:13:35,210 --> 00:13:41,150
+قيمة، تمام، جملة مش عارفة... مش عارفة، مادة صحّتها
+
+174
+00:13:41,150 --> 00:13:
+
+223
+00:17:24,350 --> 00:17:27,390
+albumin concentration في البلازما بيجي عندي
+
+224
+00:17:27,390 --> 00:17:31,550
+reagent خاص في كيت خاص للـ albumin test بيكون الـ
+
+225
+00:17:31,550 --> 00:17:35,850
+reagent يحتوي على شغلتين أساسيتين، يحتوي على الـ
+
+226
+00:17:35,850 --> 00:17:39,510
+Bromocresol Green، على هذه الـ dye، على هذه الصبغة
+
+227
+00:17:40,030 --> 00:17:47,950
+وهذه الصبغة بتكون تحمل الشحنة السالبة، تمام الصبغة
+
+228
+00:17:47,950 --> 00:17:54,250
+بتكون شحنتها سالبة، واسمها Bromocresol Green، موجودة
+
+229
+00:17:54,250 --> 00:17:58,310
+في الـ Reagent أيضًا يا جماعة، الـ Reagent يحتوي
+
+230
+00:17:58,310 --> 00:18:02,730
+على buffer، اسم الـ buffer citrate buffer، وهذا الـ
+
+231
+00:18:02,730 --> 00:18:07,310
+buffer بيعطيني acidic media، يعني بيجعل الـ Reagent
+
+232
+00:18:07,310 --> 00:18:13,850
+البيئة تشتغله acidic، تمام؟ 4.3 pH
+
+233
+00:18:13,850 --> 00:18:18,030
+جيت لو الـ Reagent هذا اللي جواته citrate Buffer و
+
+234
+00:18:18,030 --> 00:18:21,850
+جواته الـ Bromocresol Green، لما تروح تضيفيه على
+
+235
+00:18:21,850 --> 00:18:25,630
+الـ Serum تبع الـ patient اللي جواته البروتينات و
+
+236
+00:18:25,630 --> 00:18:30,830
+بما فيها الـ albumin، الـ acidic pH، لما يكون الـ pH
+
+237
+00:18:30,830 --> 00:18:37,000
+حامضي، الـ Albumin بياخد الـ Positive Charge، بياخد
+
+238
+00:18:37,000 --> 00:18:42,180
+الشحنة الموجبة، وبالتالي الصبغة شحنتها سالبة، والـ
+
+239
+00:18:42,180 --> 00:18:46,140
+Albumin شحنته موجبة، إيش حيصير؟ حيصير بينهم ارتباط
+
+240
+00:18:46,140 --> 00:18:52,040
+وبالتالي هيتكون عندي Complex، اسمه Albumin-Bromocresol Green Complex
+
+241
+00:18:52,040 --> 00:18:57,080
+Complex، وهذا الـ Complex يتم قياسه على الـ
+
+242
+00:18:57,080 --> 00:19:01,380
+Spectrophotometer، نقرأ "Forms with Bromocresol green a colored
+
+243
+00:19:01,380 --> 00:19:05,240
+compound with a color intensity proportional to
+
+244
+00:19:05,240 --> 00:19:09,200
+the albumin concentration present in the sample"
+
+245
+00:19:09,200 --> 00:19:12,240
+the albumin concentration present in the sample
+
+246
+00:19:12,240 --> 00:19:16,560
+لما ترتبط الصبغة مع الألبومين، بعطيني complex ملون
+
+247
+00:19:16,560 --> 00:19:21,080
+هذا الـ complex الملون، شدة اللون تتناسب تناسبًا طرديًا مع
+
+248
+00:19:21,080 --> 00:19:26,460
+تركيز الألبومين في العينة،الارتباط للألبومين يزيد الـ
+
+249
+00:19:26,460 --> 00:19:31,840
+Absorbance في الـ 546، بتم القراءة من جهاز
+
+250
+00:19:31,840 --> 00:19:37,580
+اللي يتم قياسه بالـ Spectrophotometer، إذا المعادلة
+
+251
+00:19:37,580 --> 00:19:40,680
+مهمة، الصبغة بتكون موجودة في الـ Reagent، الـ
+
+252
+00:19:40,680 --> 00:19:44,560
+Bromocresol Green، تحمل الشحنة السالبة، وعندنا citrate
+
+253
+00:19:44,560 --> 00:19:49,320
+Buffer اللي بيوفر لنا pH 4.3 Acidic، لما بنضيفهم على
+
+254
+00:19:49,320 --> 00:19:52,200
+عينة الـ patient اللي فيها الـ albumin، الـ albumin
+
+255
+00:19:52,200 --> 00:19:56,480
+هياخد الشحنة الموجبة، ويصير ارتباط، ويتكون هذا الـ complex
+
+256
+00:19:58,390 --> 00:20:02,770
+العينة يا جماعة، العينة المفضلة Serum، ومسموح برضه
+
+257
+00:20:02,770 --> 00:20:06,190
+بالبلازما، تمام؟ Serum is the specimen of choice،
+
+258
+00:20:06,190 --> 00:20:10,610
+fasting is not required، نفس
+
+259
+00:20:10,610 --> 00:20:15,710
+الـ total protein، الصوم مش ضروري، although it may
+
+260
+00:20:15,710 --> 00:20:20,630
+be desirable since marked lipemia interferes in
+
+261
+00:20:20,630 --> 00:20:27,590
+the BCG assay، لكن بيقول لي بنفضل الصوم عشان نتجنب
+
+262
+00:20:27,590 --> 00:20:32,090
+الليبيميا، يعني عينة ليبيميا يعني فيها لبن، فيها
+
+263
+00:20:32,090 --> 00:20:38,430
+دهون، لأن أنت بتكون ماكن، وبالتالي الدهون هتزيد في
+
+264
+00:20:38,430 --> 00:20:41,990
+العينة، وبالتالي هتتحول العينة لـ lipemic sample،
+
+265
+00:20:41,990 --> 00:20:47,730
+لونها هيك بتكون معكرة، وزي الحليب بالظبط، هذه الـ
+
+266
+00:20:47,730 --> 00:20:53,080
+lipemia هتعمل interference في طريقة الـ BCG Assay،
+
+267
+00:20:53,080 --> 00:20:57,560
+اللي هي الـ Bromocresol Green، يعني طريقة هذه الـ
+
+268
+00:20:57,560 --> 00:21:02,400
+BCG Assay، ممنوع يكون عينات المريض تكون lipemic، لو
+
+269
+00:21:02,400 --> 00:21:06,340
+كانت lipemic هتأثر على نتيجة الفحص، فعشان هيك
+
+270
+00:21:06,340 --> 00:21:11,120
+بنقول لكم بنفضل الصوم، desirable معناها يفضل
+
+271
+00:21:12,520 --> 00:21:15,780
+Venostasis should be avoided when collecting
+
+272
+00:21:15,780 --> 00:21:21,760
+samples، الـ Venostasis مصطلح يُطلق على الناس اللي
+
+273
+00:21:21,760 --> 00:21:24,960
+بتربط الـ tourniquet وبتجعد سنة لما تيجي تسحب
+
+274
+00:21:24,960 --> 00:21:30,180
+blood، يعني بربط الـ tourniquet وبعدين بروح بجيب الـ
+
+275
+00:21:30,180 --> 00:21:35,060
+needle والسرنج والكحول والسواب وأجهز أغراضي و
+
+276
+00:21:35,060 --> 00:21:38,600
+الـ tourniquet مربوط لعشر دقائق قبل السحب، هذا غلط
+
+277
+00:21:38,600 --> 00:21:43,000
+هذا في أي فحص ممنوع، أجهز أغراضي، بعدين بربط الـ
+
+278
+00:21:43,000 --> 00:21:47,400
+tourniquet، فالـ Venostasis معناها أطول فترة وأنا رابطة
+
+279
+00:21:47,400 --> 00:21:51,860
+الـ tourniquet، هذه الحالة يا جماعة بتؤدي إلى، لو
+
+280
+00:21:51,860 --> 00:21:54,980
+أنت تركت الـ tourniquet فترة مربوطة في يد المريض
+
+281
+00:21:55,440 --> 00:22:01,640
+هيؤدي ذلك إلى Hemoconcentration، تركيز الألبومين في
+
+282
+00:22:01,640 --> 00:22:07,040
+العينة، يعني الألبومين هيزيد تركيزه، ليش؟ ومش بس
+
+283
+00:22:07,040 --> 00:22:13,350
+الألبومين، يعني كل البروتينات هيزيد تركيزها، أنا بتوقع
+
+284
+00:22:13,350 --> 00:22:18,070
+إنه إيش اللي بيصير؟ هل جيت أنت طولتي في ربط الـ
+
+285
+00:22:18,070 --> 00:22:20,810
+tourniquet، تمام؟ جعدتي مثلاً ربع ساعة وأنت ربطت
+
+286
+00:22:20,810 --> 00:22:23,510
+الـ tourniquet، هل جيت الوريد اللي أنتِ بدك تجيئي
+
+287
+00:22:23,510 --> 00:22:28,470
+تحطي فيه الـ needle؟ نتيجة الضغط بيصير يطلع
+
+288
+00:22:28,470 --> 00:22:34,470
+السوائل اللي موجودة فيه لخارج أنسجة الجسم، وبالتالي
+
+289
+00:22:34,470 --> 00:22:38,350
+هيضل فيه شو؟ في الوريد إيش هيضل فيه؟ هيضل فقط
+
+290
+00:22:38,350 --> 00:22:43,750
+الـ بروتينات متركزة فيه، لكن السوائل اللي كانت
+
+291
+00:22:43,750 --> 00:22:49,190
+البروتينات بتسبح فيها، طلع من كتر الضغط على اليد
+
+292
+00:22:49,190 --> 00:22:53,850
+إذا وجود الـ tourniquet هيجعل الـ body fluid
+
+293
+00:22:53,850 --> 00:23:00,600
+السوائل الموجودة في الأوعية تطلع لبرة، تطلع خارج
+
+294
+00:23:00,600 --> 00:23:04,660
+الجسم، تمام؟ مش خارج الجسم يعني إحنا نشوفها،
+
+295
+00:23:04,660 --> 00:23:08,680
+تطلع يعني إلى أنسجة الجسم، وبالتالي الوريد نفسه
+
+296
+00:23:08,680 --> 00:23:11,780
+اللي هحط فيه الـ needle، هيكون فيه بروتينات أكثر،
+
+297
+00:23:11,780 --> 00:23:16,320
+يعني هيكون فيه مليان بروتينات متركزة، تمام؟ إذن
+
+298
+00:23:16,320 --> 00:23:19,380
+بدنا نتجنب الـ venostasis، تمام؟
+
+299
+00:23:21,910 --> 00:23:25,490
+البروسيجر لفحص الـ Albumin Test، نفس الـ Total
+
+300
+00:23:25,490 --> 00:23:28,690
+بروتين يا جماعة بالظبط، بس طبعاً الـ Reagent بختلف
+
+301
+00:23:28,690 --> 00:23:33,190
+بتجيبي تلات أنابيب، تكتبي الـ Blank وStandard والـ
+
+302
+00:23:33,190 --> 00:23:37,630
+Patient Sample، بتجيبي الـ Reagent تبع الـ Albumin
+
+303
+00:23:37,630 --> 00:23:42,170
+بتحطي على التلات أنابيب 1000 ميكرولتر، علبة الـ
+
+304
+00:23:42,170 --> 00:23:45,050
+Standard بتكون جاية مع الـ Kit، هذا الـ Standard
+
+305
+00:23:45,050 --> 00:23:49,390
+جواته مادة الألبومين وإله تركيز معين، بتكون مكتوب
+
+306
+00:23:49,390 --> 00:23:53,350
+على العلبة نفسها، تمام؟ تاخدي منها 5 ميكرولتر،
+
+307
+00:23:53,350 --> 00:23:57,150
+تحطيها في أنبوبة الـ Standard، تعملي mix، تيجي على
+
+308
+00:23:57,150 --> 00:24:00,410
+الـ Serum أو البلازما تبع الـ patient، تاخدي منه 5
+
+309
+00:24:00,410 --> 00:24:04,350
+ميكرولتر، وبتحطيها في أنبوبة الـ Patient، تعملي mix
+
+310
+00:24:05,270 --> 00:24:08,730
+بعد ما تعمل mix للأنابيب، برضه incubation، عشرة
+
+311
+00:24:08,730 --> 00:24:11,650
+minutes at room temperature، تضبطي الجهاز الـ
+
+312
+00:24:11,650 --> 00:24:16,390
+Spectrophotometer على 546، أول شيء بقرا الـ blank
+
+313
+00:24:16,390 --> 00:24:20,570
+بعدين بقرا الـ standard وباخد absorbance له، وبقرا
+
+314
+00:24:20,570 --> 00:24:24,250
+الـ sample وباخد absorbance له، الـ color تبع
+
+315
+00:24:24,250 --> 00:24:28,920
+التفاعل بيضل stable لمدة ساعة، وفي الآخر بالطبق
+
+316
+00:24:28,920 --> 00:24:32,700
+الـ Beer's Law، الـ Concentration للـ Sample تساوي
+
+317
+00:24:32,700 --> 00:24:37,100
+الـ Absorbance للـ Sample على الـ Absorbance للـ
+
+318
+00:24:37,100 --> 00:24:40,320
+Standard ضرب Concentration للـ Standard، كل
+
+319
+00:24:40,320 --> 00:24:44,760
+الشغلات اللي في القانون موجودة، بحط الأرقام وبجيب
+
+320
+00:24:44,760 --> 00:24:52,710
+تركيز الألبومين بالـ mg/dl، تمام؟ هنا يا
+
+321
+00:24:52,710 --> 00:24:56,630
+جماعة كاتب لكم الـ Reference Range للـ albumin
+
+322
+00:24:56,630 --> 00:25:02,750
+للـ Adult اللي بيكون أعمارهم من 21 سنة لـ 44 سنة
+
+323
+00:25:02,750 --> 00:25:09,030
+عند الرجال بيكون 33 لـ 61 g/L، قلت لكم لو
+
+324
+00:25:09,030 --> 00:25:17,310
+بدي g/dL بقسم على 10، يعني 3.3 لـ 6.1 g/dL
+
+325
+00:25:17,310 --> 00:25:24,380
+وعند النساء من 2.7 لـ 5.6 g/dL
+
+326
+00:25:24,380 --> 00:25:31,350
+تركيز الألبومين، تمام؟ Interfering
+
+327
+00:25:31,350 --> 00:25:38,950
+factors، شغلات بتعمل لبس أثناء قياس الـ albumin
+
+328
+00:25:38,950 --> 00:25:43,170
+albumin is decreased in، يعني الألبومين بيقل في
+
+329
+00:25:43,170 --> 00:25:47,350
+حالات مختلفة، حالات pregnancy، المرأة الحامل بيقل
+
+330
+00:25:47,350 --> 00:25:51,010
+بس هذا مش حالة مرضية يا جماعة، بدنا نفهم حالة عرضية
+
+331
+00:25:51,010 --> 00:25:54,430
+يعني خلاص بعد ما تولد المرأة، برجع الألبومين طبيعي
+
+332
+00:25:55,030 --> 00:25:58,770
+المرأة الحامل بتكون عندها بلازما كثيرة، وبالتالي
+
+333
+00:25:58,770 --> 00:26:04,430
+الألبومين هيتخفف، تمام؟ last trimester، خاصة في آخر
+
+334
+00:26:04,430 --> 00:26:08,450
+شهر، owing to increased plasma volume، السبب أن الـ
+
+335
+00:26:08,450 --> 00:26:12,470
+plasma volume عندها حجمه كبير، وبالتالي بتخفف
+
+336
+00:26:12,470 --> 00:26:16,510
+الألبومين، الناس اللي بتاخد oral birth control، حبوب
+
+337
+00:26:16,510 --> 00:26:21,610
+تنظيم النسل، هذه الحبوب فيها استروجين، تمام؟ وبعض
+
+338
+00:26:21,610 --> 00:26:25,550
+الأدوية بتخفض من مستوى الألبومين في الدم، prolonged
+
+339
+00:26:25,550 --> 00:26:31,350
+bed rest، الناس اللي بيقعدوا لفترات طويلة قاعدين،
+
+340
+00:26:31,350 --> 00:26:36,710
+تمام؟ دائمًا يعني يعني نوع الكسول اللي دائمًا طول
+
+341
+00:26:36,710 --> 00:26:40,350
+حياته هو قاعد، هذا لو فحصنا ألبومينه هتلاقي عنده
+
+342
+00:26:40,350 --> 00:26:45,270
+منخفض، على عكس يا جماعة، إذا بتسمعوا شخص بيوقف كثير
+
+343
+00:26:46,170 --> 00:26:50,010
+شغله هيك وهو دائمًا هو واقف، الشغل تبعه بيطلب إنه
+
+344
+00:26:50,010 --> 00:26:53,750
+يضل واقف، لو جينا فحصناه، أخدنا منه عينة urine
+
+345
+00:26:53,750 --> 00:26:58,690
+وعملنا فيه الـ strip، هتلاقي خانة البروتين موجبة، فيها
+
+346
+00:26:58,690 --> 00:27:02,430
+بروتين، الـ urine تبعه فيه بروتين، مش تحكي لي والله
+
+347
+00:27:02,430 --> 00:27:05,970
+عنده مشكلة في الكلى، الكلى سربت البروتين في الـ
+
+348
+00:27:05,970 --> 00:27:10,970
+urine، لأ، بتكون المشكلة الوقفة الكثيرة ولفترات
+
+349
+00:27:10,970 --> 00:27:16,170
+طويلة، بتنزل البروتين في الـ urine، تمام؟ نفس الشيء
+
+350
+00:27:16,170 --> 00:27:20,210
+هنا، شخص نايم كثير، هذا دائمًا بيكون عنده الألبومين
+
+351
+00:27:20,210 --> 00:27:25,430
+منخفض، الناس الـ Intravenous Fluid، بركب محلول وأجي
+
+352
+00:27:25,430 --> 00:27:28,510
+أسحب له عينة من منطقة المحلول، مسائل يعني
+
+353
+00:27:28,510 --> 00:27:31,230
+البروتينات اللي في منطقة المحلول هتكون
+
+354
+00:27:31,230 --> 00:27:35,650
+مخففة، المحلول اللي هو الـ Rapid Hydration، تعطي أنتَ
+
+355
+00:27:35,650 --> 00:27:40,650
+محلول سريع أو "Over Hydration"، يعني تعطي محلول
+
+356
+00:27:40,650 --> 00:27:44,610
+كثير، يكون عنده جفاف، وتعطي محلول كثير، تسحب منه
+
+357
+00:27:44,610 --> 00:27:49,130
+عينة، هتلاقي البروتينات قليلة، تركيزها قليل لأنها
+
+358
+00:27:49,130 --> 00:27:55,860
+مخففة، Note a urine microalbumin test is a test to
+
+359
+00:27:55,860 --> 00:27:59,440
+detect very small levels of blood protein albumin
+
+360
+00:27:59,440 --> 00:28:03,720
+in your urine، هذا الفحص اسمه urine microalbumin
+
+361
+00:28:03,720 --> 00:28:08,880
+test، أو إله اسم آخر microalbuminuria test، يستخدم
+
+362
+00:28:08,880 --> 00:28:15,580
+للكشف عن الألبومين حتى لو كان تركيز هذا الـ
+
+363
+00:28:15,580 --> 00:28:22,040
+albumin very very small في الـ urine، هذا يا جماعة
+
+364
+00:28:22,040 --> 00:28:29,210
+الفحص ممكن يكون بيشتغل بطريقتين، ممكن يكون qualitative
+
+365
+00:28:29,210 --> 00:28:35,130
+وممكن يكون quantitative، qualitative نظام الـ strip، شفت
+
+366
+00:28:35,130 --> 00:28:41,990
+strip الحمل؟ نفس النظام، بروح بحط نقطة urine وبيطلع
+
+367
+00:28:41,990 --> 00:28:46,830
+الـ urine بالـ strip وبعطيك خطين، لو أعطاك خطين الـ
+
+368
+00:28:46,830 --> 00:28:51,870
+strip معناها في عنده ألبومين في الـ urine، إذا طريقة
+
+369
+00:28:51,870 --> 00:28:55,430
+qualitative، يعني عنده ألبومين في الـ urine ولا ما
+
+370
+00:28:55,430 --> 00:29:01,260
+عنده، أما الطريقة quantitative، فإله Kit خاص
+
+371
+00:29:01,260 --> 00:29:05,680
+اسمه Kit الـ Microalbuminuria Test، هذا الـ Kit
+
+372
+00:29:05,680 --> 00:29:10,880
+بيقيس لي تركيز الألبومين بالظبط، قد ايش تركيز الألبومين
+
+373
+00:29:10,880 --> 00:29:15,460
+بالظبط اللي موجود في الـ urine حتى لو كانت كميته
+
+374
+00:29:15,460 --> 00:29:19,400
+قليلة، فإله Kit خاص فيه، إذا بنشغل الفحص إما
+
+375
+00:29:19,400 --> 00:29:23,040
+qualitative يعني موجود الألبومين ولا لأ، أو
+
+376
+00:29:23,040 --> 00:29:27,990
+quantitative، ممكن برضه أحسب تركيزه في الـ urine، A
+
+377
+00:29:27,990 --> 00:29:32,370
+microalbumin test is used، استخدام هذا الفحص to
+
+378
+00:29:32,370 --> 00:29:36,110
+detect the early signs of kidney damage in people
+
+379
+00:29:36,110 --> 00:29:39,510
+who are at risk of developing kidney disease
+
+380
+00:29:39,510 --> 00:29:44,790
+أحيانًا يا جماعة، هذا الفحص كتير مهم لمرضى السكري،
+
+381
+00:29:44,790 --> 00:29:49,250
+بين فترة وفترة أعملهم إياه، لأن حكينا بيصير عندهم
+
+382
+00:29:49,250 --> 00:29:53,650
+مضاعفات، ومن المضاعفات nephropathy، مشاكل في
+
+383
+00:29:53,650 --> 00:29:57,750
+النفريون في الكلى، فتبدأ الكلى تسرب عندهم الألبومين
+
+384
+00:29:57,860 --> 00:30:04,340
+فأنا بدي أعمل detection early، بدي أعمل كشف مبكر عن
+
+385
+00:30:04,340 --> 00:30:07,880
+الخلل اللي بده يصيب الكلى، يعني أول ما الكلى تبدأ
+
+386
+00:30:07,880 --> 00:30:13,640
+تنزل ألبومين، بدي أكشف بسرعة هذه المشكلة عشان ألحق
+
+387
+00:30:13,640 --> 00:30:17,980
+المريض، أعطيه علاج قبل ما نوصل لمراحل يصير عنده
+
+388
+00:30:17,980 --> 00:30:25,560
+الـ فشل كلوي كامل، تمام؟ فإحنا مهم الي عشان early
+
+389
+00:30:25,560 --> 00:30:30,340
+detection، نكشف كشف مبكر عن الألبومين اللي موجود في
+
+390
+00:30:30,340 --> 00:30:36,920
+الـ urine عشان نمنع الـ complications، تمام؟
+
+391
+00:30:36,920 --> 00:30:37,820
+يعطيكم العافية
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/1cu0B0Ynj-c_raw.json b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/1cu0B0Ynj-c_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..5e3c793206e67744ed470c1f8feb8b25c7ee7596
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/1cu0B0Ynj-c_raw.json
@@ -0,0 +1 @@
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115.5, "word": " نوعه", "probability": 0.8873697916666666}, {"start": 115.5, "end": 116.02, "word": " globular", "probability": 0.6805419921875}, {"start": 116.02, "end": 116.52, "word": " protein", "probability": 0.90966796875}], "temperature": 1.0}, {"id": 6, "seek": 14047, "start": 116.77, "end": 140.47, "text": "with a molecular weight of approximately 66 ألف دالتون مش مشكلة نعرف حجم البروتين and is unique among major plasma proteins in containing no carbohydrate يعني هو الـ major بروتين اللي موجود في الـ plasma اتهزر relatively low content of tryptophan ألبوم عبارة عن سلفلة من الأحماض الأمينية", "tokens": [11820, 257, 19046, 3364, 295, 10447, 21126, 5551, 46538, 11778, 6027, 2655, 11536, 37893, 37893, 28820, 3660, 8717, 3615, 28480, 11331, 7435, 2304, 2423, 26890, 35473, 9957, 293, 307, 3845, 3654, 2563, 22564, 15577, 294, 19273, 572, 47048, 37495, 22653, 31439, 2423, 39184, 2563, 4724, 32887, 2655, 9957, 13672, 1829, 3714, 29245, 23328, 8978, 2423, 39184, 22564, 1975, 47395, 11622, 2288, 7226, 2295, 2701, 295, 853, 662, 404, 3451, 5551, 46152, 20498, 6225, 3555, 9640, 3660, 18871, 8608, 46538, 37977, 9154, 16247, 35571, 46958, 16247, 2304, 9957, 10632], "avg_logprob": -0.18469100453880397, "compression_ratio": 1.4621212121212122, "no_speech_prob": 0.0, "words": [{"start": 116.77, "end": 116.95, "word": "with", "probability": 0.2459716796875}, {"start": 116.95, "end": 117.11, "word": " a", "probability": 0.95849609375}, {"start": 117.11, "end": 117.45, "word": " molecular", "probability": 0.79345703125}, {"start": 117.45, "end": 117.89, "word": " weight", "probability": 0.919921875}, {"start": 117.89, "end": 118.05, "word": " of", "probability": 0.9677734375}, {"start": 118.05, "end": 118.69, "word": " approximately", "probability": 0.73388671875}, {"start": 118.69, "end": 119.33, "word": " 66", "probability": 0.82177734375}, {"start": 119.33, "end": 119.89, "word": " ألف", "probability": 0.6929931640625}, {"start": 119.89, "end": 120.45, "word": " دالتون", "probability": 0.962890625}, {"start": 120.45, "end": 120.71, "word": " مش", "probability": 0.59716796875}, {"start": 120.71, "end": 121.19, "word": " مشكلة", "probability": 0.9850260416666666}, {"start": 121.19, "end": 121.47, "word": " نعرف", "probability": 0.9856770833333334}, {"start": 121.47, "end": 121.81, "word": " حجم", "probability": 0.9903971354166666}, {"start": 121.81, "end": 122.39, "word": " البروتين", "probability": 0.9437255859375}, {"start": 122.39, "end": 123.11, "word": " and", "probability": 0.80810546875}, {"start": 123.11, "end": 123.37, "word": " is", "probability": 0.89697265625}, {"start": 123.37, "end": 123.79, "word": " unique", "probability": 0.873046875}, {"start": 123.79, "end": 124.49, "word": " among", "probability": 0.96875}, {"start": 124.49, "end": 125.13, "word": " major", "probability": 0.93408203125}, {"start": 125.13, "end": 125.81, "word": " plasma", "probability": 0.94775390625}, {"start": 125.81, "end": 126.47, "word": " proteins", "probability": 0.935546875}, {"start": 126.47, "end": 127.01, "word": " in", "probability": 0.5439453125}, {"start": 127.01, "end": 127.51, "word": " containing", "probability": 0.91064453125}, {"start": 127.51, "end": 127.77, "word": " no", "probability": 0.68798828125}, {"start": 127.77, "end": 128.55, "word": " carbohydrate", "probability": 0.73974609375}, {"start": 128.55, "end": 129.05, "word": " يعني", "probability": 0.832763671875}, {"start": 129.05, "end": 129.33, "word": " هو", "probability": 0.9794921875}, {"start": 129.33, "end": 130.01, "word": " الـ", "probability": 0.76513671875}, {"start": 130.01, "end": 130.23, "word": " major", "probability": 0.56201171875}, {"start": 130.23, "end": 130.87, "word": " بروتين", "probability": 0.893798828125}, {"start": 130.87, "end": 131.23, "word": " اللي", "probability": 0.90869140625}, {"start": 131.23, "end": 131.75, "word": " موجود", "probability": 0.9903971354166666}, {"start": 131.75, "end": 132.03, "word": " في", "probability": 0.97900390625}, {"start": 132.03, "end": 132.43, "word": " الـ", "probability": 0.443115234375}, {"start": 132.43, "end": 132.67, "word": " plasma", "probability": 0.5791015625}, {"start": 132.67, "end": 133.79, "word": " اتهزر", "probability": 0.788330078125}, {"start": 133.79, "end": 134.37, "word": " relatively", "probability": 0.474853515625}, {"start": 134.37, "end": 135.39, "word": " low", "probability": 0.8662109375}, {"start": 135.39, "end": 135.81, "word": " content", "probability": 0.9638671875}, {"start": 135.81, "end": 136.27, "word": " of", "probability": 0.974609375}, {"start": 136.27, "end": 136.97, "word": " tryptophan", "probability": 0.9398193359375}, {"start": 136.97, "end": 137.51, "word": " ألبوم", "probability": 0.608642578125}, {"start": 137.51, "end": 138.19, "word": " عبارة", "probability": 0.928466796875}, {"start": 138.19, "end": 138.51, "word": " عن", "probability": 0.9970703125}, {"start": 138.51, "end": 139.07, "word": " سلفلة", "probability": 0.6917317708333334}, {"start": 139.07, "end": 139.23, "word": " من", "probability": 0.99072265625}, {"start": 139.23, "end": 139.75, "word": " الأحماض", "probability": 0.8963216145833334}, {"start": 139.75, "end": 140.47, "word": " الأمينية", "probability": 0.9307861328125}], "temperature": 1.0}, {"id": 7, "seek": 15443, "start": 141.23, "end": 154.43, "text": "الـ Cryptophan هو عبارة عن أمينو أسد حمض أميني لكن الألبومين لا يعني بيحتوي على Cryptophan على هذا الحمض الأميني ولكن ب low concentration بكميات قليلة", "tokens": [6027, 39184, 34809, 404, 3451, 31439, 6225, 3555, 9640, 3660, 18871, 5551, 2304, 9957, 2407, 5551, 3794, 3215, 11331, 2304, 11242, 5551, 2304, 9957, 1829, 44381, 16247, 46152, 20498, 9957, 20193, 37495, 22653, 4724, 1829, 33753, 45865, 15844, 34809, 404, 3451, 15844, 23758, 21542, 2304, 11242, 16247, 2304, 9957, 1829, 35525, 19452, 4724, 2295, 9856, 4724, 24793, 1829, 9307, 12174, 20292, 37977], "avg_logprob": -0.17708334042912438, "compression_ratio": 1.484472049689441, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 141.23, "end": 142.03, "word": "الـ", "probability": 0.937255859375}, {"start": 142.03, "end": 142.59, "word": " Cryptophan", "probability": 0.6490885416666666}, {"start": 142.59, "end": 142.77, "word": " هو", "probability": 0.92236328125}, {"start": 142.77, "end": 143.13, "word": " عبارة", "probability": 0.9974365234375}, {"start": 143.13, "end": 143.29, "word": " عن", "probability": 0.99560546875}, {"start": 143.29, "end": 143.61, "word": " أمينو", "probability": 0.77496337890625}, {"start": 143.61, "end": 143.91, "word": " أسد", "probability": 0.8738606770833334}, {"start": 143.91, "end": 144.27, "word": " حمض", "probability": 0.7980143229166666}, {"start": 144.27, "end": 144.79, "word": " أميني", "probability": 0.9312744140625}, {"start": 144.79, "end": 145.25, "word": " لكن", "probability": 0.7470703125}, {"start": 145.25, "end": 146.31, "word": " الألبومين", "probability": 0.78131103515625}, {"start": 146.31, "end": 146.85, "word": " لا", "probability": 0.2288818359375}, {"start": 146.85, "end": 147.45, "word": " يعني", "probability": 0.939697265625}, {"start": 147.45, "end": 148.31, "word": " بيحتوي", "probability": 0.9385986328125}, {"start": 148.31, "end": 148.55, "word": " على", "probability": 0.95458984375}, {"start": 148.55, "end": 149.43, "word": " Cryptophan", "probability": 0.8343098958333334}, {"start": 149.43, "end": 150.05, "word": " على", "probability": 0.87939453125}, {"start": 150.05, "end": 150.33, "word": " هذا", "probability": 0.939453125}, {"start": 150.33, "end": 150.59, "word": " الحمض", "probability": 0.9827473958333334}, {"start": 150.59, "end": 151.07, "word": " الأميني", "probability": 0.9779052734375}, {"start": 151.07, "end": 151.79, "word": " ولكن", "probability": 0.873046875}, {"start": 151.79, "end": 152.03, "word": " ب", "probability": 0.87744140625}, {"start": 152.03, "end": 152.19, "word": " low", "probability": 0.50146484375}, {"start": 152.19, "end": 152.89, "word": " concentration", "probability": 0.80322265625}, {"start": 152.89, "end": 153.87, "word": " بكميات", "probability": 0.900634765625}, {"start": 153.87, "end": 154.43, "word": " قليلة", "probability": 0.9861653645833334}], "temperature": 1.0}, {"id": 8, "seek": 17121, "start": 155.65, "end": 171.21, "text": "And is an anion at pH 7.4 يعني هذا البروتين يحمل شحنة ثالثة لما يكون الـ pH تبع الدم neutral متعادل 7.4 وهذا الطبيعي", "tokens": [5289, 307, 364, 364, 313, 412, 21677, 1614, 13, 19, 37495, 22653, 23758, 2423, 26890, 35473, 9957, 7251, 35571, 1211, 13412, 5016, 1863, 3660, 38637, 6027, 12984, 3660, 5296, 15042, 7251, 30544, 2423, 39184, 21677, 6055, 3555, 3615, 32748, 2304, 10598, 44650, 3615, 18513, 1211, 1614, 13, 19, 37037, 15730, 41950, 21292, 3615, 1829], "avg_logprob": -0.1916193187236786, "compression_ratio": 1.2447552447552448, "no_speech_prob": 7.152557373046875e-07, "words": [{"start": 155.64999999999998, "end": 156.73, "word": "And", "probability": 0.2142333984375}, {"start": 156.73, "end": 157.03, "word": " is", "probability": 0.87353515625}, {"start": 157.03, "end": 157.41, "word": " an", "probability": 0.92626953125}, {"start": 157.41, "end": 157.95, "word": " anion", "probability": 0.931640625}, {"start": 157.95, "end": 158.37, "word": " at", "probability": 0.8076171875}, {"start": 158.37, "end": 158.89, "word": " pH", "probability": 0.92626953125}, {"start": 158.89, "end": 159.23, "word": " 7", "probability": 0.89599609375}, {"start": 159.23, "end": 160.31, "word": ".4", "probability": 0.99365234375}, {"start": 160.31, "end": 160.89, "word": " يعني", "probability": 0.815673828125}, {"start": 160.89, "end": 161.27, "word": " هذا", "probability": 0.8671875}, {"start": 161.27, "end": 161.97, "word": " البروتين", "probability": 0.89111328125}, {"start": 161.97, "end": 162.85, "word": " يحمل", "probability": 0.9869791666666666}, {"start": 162.85, "end": 163.57, "word": " شحنة", "probability": 0.9176025390625}, {"start": 163.57, "end": 164.33, "word": " ثالثة", "probability": 0.835693359375}, {"start": 164.33, "end": 164.97, "word": " لما", "probability": 0.83837890625}, {"start": 164.97, "end": 165.57, "word": " يكون", "probability": 0.857421875}, {"start": 165.57, "end": 165.99, "word": " الـ", "probability": 0.7158203125}, {"start": 165.99, "end": 166.53, "word": " pH", "probability": 0.923828125}, {"start": 166.53, "end": 167.03, "word": " تبع", "probability": 0.7392578125}, {"start": 167.03, "end": 167.49, "word": " الدم", "probability": 0.965087890625}, {"start": 167.49, "end": 168.33, "word": " neutral", "probability": 0.343505859375}, {"start": 168.33, "end": 169.41, "word": " متعادل", "probability": 0.8304443359375}, {"start": 169.41, "end": 169.73, "word": " 7", "probability": 0.7724609375}, {"start": 169.73, "end": 170.45, "word": ".4", "probability": 0.995849609375}, {"start": 170.45, "end": 170.71, "word": " وهذا", "probability": 0.721923828125}, {"start": 170.71, "end": 171.21, "word": " الطبيعي", "probability": 0.962646484375}], "temperature": 1.0}, {"id": 9, "seek": 19415, "start": 171.63, "end": 194.15, "text": "إن الـ pH تبعت الدم عند الإنسان الطبيعي نيوترال وبالتالي الألبومين في هذا الوقت بيحمل الشحنة السالبة. These properties have been exploited in the estimation of albumin in body fluids. هذه الصفات والخصائص بتاعة الألبومين مكنتنا من معرفة طرق من أجل حساب تركيز الألبومين في البلازمة.", "tokens": [28814, 1863, 2423, 39184, 21677, 6055, 3555, 34268, 32748, 2304, 43242, 33688, 1863, 3794, 7649, 41950, 21292, 3615, 1829, 8717, 1829, 35473, 2288, 6027, 46599, 6027, 2655, 6027, 1829, 16247, 46152, 20498, 9957, 8978, 23758, 2423, 30543, 2655, 4724, 1829, 35571, 1211, 25124, 5016, 1863, 3660, 21136, 6027, 49401, 13, 1981, 7221, 362, 668, 40918, 294, 264, 35701, 295, 6030, 259, 294, 1772, 33033, 13, 29538, 31767, 5172, 9307, 16070, 9778, 9381, 16373, 9381, 39894, 995, 27884, 16247, 46152, 20498, 9957, 3714, 19452, 2655, 8315, 9154, 20449, 28480, 3660, 23032, 2288, 4587, 9154, 5551, 7435, 1211, 11331, 3794, 16758, 6055, 31747, 1829, 11622, 16247, 46152, 20498, 9957, 8978, 29739, 1211, 31377, 46007, 13], "avg_logprob": -0.16173246084598072, "compression_ratio": 1.6131386861313868, "no_speech_prob": 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"probability": 0.97509765625}, {"start": 176.27, "end": 176.51, "word": " هذا", "probability": 0.8876953125}, {"start": 176.51, "end": 176.89, "word": " الوقت", "probability": 0.9886067708333334}, {"start": 176.89, "end": 177.37, "word": " بيحمل", "probability": 0.939453125}, {"start": 177.37, "end": 177.87, "word": " الشحنة", "probability": 0.9556884765625}, {"start": 177.87, "end": 178.31, "word": " السالبة.", "probability": 0.8167317708333334}, {"start": 178.77, "end": 179.03, "word": " These", "probability": 0.32861328125}, {"start": 179.03, "end": 179.59, "word": " properties", "probability": 0.74267578125}, {"start": 179.59, "end": 180.17, "word": " have", "probability": 0.9404296875}, {"start": 180.17, "end": 180.45, "word": " been", "probability": 0.927734375}, {"start": 180.45, "end": 181.19, "word": " exploited", "probability": 0.92724609375}, {"start": 181.19, "end": 181.67, "word": " in", "probability": 0.92431640625}, {"start": 181.67, "end": 181.81, "word": " the", "probability": 0.90771484375}, {"start": 181.81, "end": 182.31, "word": " estimation", "probability": 0.95263671875}, {"start": 182.31, "end": 182.63, "word": " of", "probability": 0.95751953125}, {"start": 182.63, "end": 183.19, "word": " albumin", "probability": 0.6259765625}, {"start": 183.19, "end": 183.49, "word": " in", "probability": 0.9404296875}, {"start": 183.49, "end": 183.69, "word": " body", "probability": 0.84814453125}, {"start": 183.69, "end": 184.15, "word": " fluids.", "probability": 0.94140625}, {"start": 184.51, "end": 184.79, "word": " هذه", "probability": 0.91259765625}, {"start": 184.79, "end": 186.13, "word": " الصفات", "probability": 0.98681640625}, {"start": 186.13, "end": 186.65, "word": " والخصائص", "probability": 0.9095703125}, {"start": 186.65, "end": 186.89, "word": " بتاعة", "probability": 0.580078125}, {"start": 186.89, "end": 187.53, "word": " الألبومين", "probability": 0.9371337890625}, {"start": 187.53, "end": 188.35, "word": " مكنتنا", 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لحساب الـ Totally Protein وبرضه في عندي طرق كتيرة لحساب الـ Albumin، تركيز الـ Albumin في بلازم الدم أول طريقة، طريقة الترسيب الـ Precipitation وهذه طريقة quantitative يعني بتعطيكي تركيز الـ Albumin بدقة بتعطيكي قيمة عددية، رقمية", "tokens": [6027, 39184, 38172, 25285, 82, 30767, 1829, 19446, 11331, 4117, 1829, 8315, 8978, 43242, 8315, 23032, 2288, 4587, 9122, 2655, 13546, 5296, 5016, 3794, 16758, 2423, 39184, 22837, 43371, 259, 4032, 26890, 11242, 3224, 8978, 18871, 16254, 23032, 2288, 4587, 9122, 2655, 48923, 5296, 5016, 3794, 16758, 2423, 39184, 967, 5559, 259, 12399, 6055, 31747, 1829, 11622, 2423, 39184, 967, 5559, 259, 8978, 4724, 1211, 31377, 2304, 32748, 2304, 5551, 12610, 23032, 16572, 28671, 12399, 23032, 16572, 28671, 16712, 2288, 3794, 1829, 3555, 2423, 39184, 430, 3326, 79, 4614, 37037, 24192, 23032, 16572, 28671, 27778, 37495, 22653, 39894, 3615, 9566, 1829, 4117, 1829, 6055, 31747, 1829, 11622, 2423, 39184, 967, 5559, 259, 47525, 28671, 39894, 3615, 9566, 1829, 4117, 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"word": " كريزول", "probability": 0.988525390625}, {"start": 562.44, "end": 562.92, "word": " بيربل", "probability": 0.806640625}, {"start": 562.92, "end": 563.26, "word": " هذه", "probability": 0.7666015625}, {"start": 563.26, "end": 563.94, "word": " أنواع", "probability": 0.974609375}, {"start": 563.94, "end": 564.3, "word": " الـ", "probability": 0.97900390625}, {"start": 564.3, "end": 564.56, "word": " dye", "probability": 0.68408203125}], "temperature": 1.0}, {"id": 28, "seek": 58549, "start": 565.23, "end": 585.49, "text": "تمام؟ وهذه طريقة quantitative برضه هذه طريقة أخرى نفس المبدأ dye-binding ولكنها semi-quantitative شفتوا، أحطوا في السوائل الخانة التابعة لـ protein مش بيكون عندنا protein", "tokens": [39237, 10943, 22807, 37037, 24192, 23032, 16572, 28671, 27778, 4724, 43042, 3224, 29538, 23032, 16572, 28671, 5551, 34740, 7578, 8717, 36178, 9673, 44510, 10721, 20179, 12, 65, 9245, 35525, 19452, 11296, 12909, 12, 358, 394, 14275, 13412, 5172, 2655, 14407, 12399, 5551, 5016, 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{"start": 604.93, "end": 605.27, "word": " الـ", "probability": 0.5013427734375}, {"start": 605.27, "end": 605.59, "word": " albumin", "probability": 0.972900390625}, {"start": 605.59, "end": 605.77, "word": " نوع", "probability": 0.7352294921875}, {"start": 605.77, "end": 605.87, "word": " من", "probability": 0.9951171875}, {"start": 605.87, "end": 606.17, "word": " أنواع", "probability": 0.9222005208333334}, {"start": 606.17, "end": 606.83, "word": " البروتينات", "probability": 0.9234375}, {"start": 606.83, "end": 607.15, "word": " هل", "probability": 0.828857421875}, {"start": 607.15, "end": 607.65, "word": " موجود", "probability": 0.9866536458333334}, {"start": 607.65, "end": 607.95, "word": " الـ", "probability": 0.8583984375}, {"start": 607.95, "end": 608.37, "word": " albumin", "probability": 0.98486328125}, {"start": 608.37, "end": 608.71, "word": " في", "probability": 0.9873046875}, {"start": 608.71, "end": 608.85, "word": " الـ", "probability": 0.97705078125}, {"start": 608.85, "end": 609.13, "word": " urine", "probability": 0.9912109375}, {"start": 609.13, "end": 609.53, "word": " ولا", "probability": 0.90625}, {"start": 609.53, "end": 609.75, "word": " لا", "probability": 0.900390625}, {"start": 609.75, "end": 610.55, "word": " ففي", "probability": 0.865234375}, {"start": 610.55, "end": 611.11, "word": " الخانة", "probability": 0.9793294270833334}, {"start": 611.11, "end": 611.59, "word": " تبعت", "probability": 0.8854166666666666}, {"start": 611.59, "end": 612.15, "word": " الـ", "probability": 0.9287109375}, {"start": 612.15, "end": 612.63, "word": " albumin", "probability": 0.980224609375}], "temperature": 1.0}, {"id": 30, "seek": 63687, "start": 612.83, "end": 636.87, "text": "بيكون عندنا صبغة اسمها Bromophenol Blue صح ولا لأ؟ ولون المربع لون المربع في الـ Strip بيكون أصفر إذا فكرين فلو حطيت الـ Strip في عينة اليورين وكان اليورين جواته ألبومان الألبومان هيتفاعل مع هذه الصبغة مع الـ Bromophenol Blue", "tokens": [3555, 1829, 30544, 43242, 8315, 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636.55, "end": 636.87, "word": " Blue", "probability": 0.9599609375}], "temperature": 1.0}, {"id": 31, "seek": 66088, "start": 637.4, "end": 660.88, "text": "ويحول اللون الأصفر للون أزرق فاللون الأزرق معناه إنه فيه ألبوم في الـ urine بروموفينولي بلو انتستريب في الـ strip changed color بتغير اللون من أصفر لأزرق معناه في عندنا ألبوم وهذه الطريقة الشائعة للكشف عن البروتين جواة الألبوم", "tokens": [2407, 1829, 5016, 12610, 13672, 11536, 16247, 9381, 5172, 2288, 5296, 1211, 11536, 5551, 11622, 2288, 4587, 6156, 6027, 1211, 11536, 16247, 11622, 2288, 4587, 20449, 8315, 3224, 36145, 3224, 8978, 3224, 5551, 46152, 20498, 8978, 2423, 39184, 27638, 4724, 2288, 20498, 38688, 9957, 12610, 1829, 4724, 1211, 2407, 16472, 2655, 14851, 16572, 3555, 8978, 2423, 39184, 12828, 3105, 2017, 39894, 17082, 13546, 13672, 11536, 9154, 5551, 9381, 5172, 2288, 5296, 10721, 11622, 2288, 4587, 20449, 8315, 3224, 8978, 43242, 8315, 5551, 46152, 20498, 4032, 3224, 24192, 41950, 16572, 28671, 25124, 16373, 27884, 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lipemic sample لونها هيك بتكون معكرة وزي الحليب بالظبط هذه الـ lipemia هتعمل interference", "tokens": [1211, 33456, 16472, 2655, 39894, 30544, 3714, 995, 19452, 46599, 6027, 2655, 6027, 1829, 32748, 3224, 11536, 8032, 2655, 11622, 25708, 8978, 3224, 18863, 9957, 3660, 46599, 6027, 2655, 6027, 1829, 8032, 2655, 2655, 5016, 12610, 18863, 9957, 3660, 5296, 39184, 8280, 3438, 6889, 5296, 11536, 11296, 39896, 4117, 39894, 30544, 20449, 4117, 25720, 4032, 11622, 1829, 21542, 20292, 3555, 20666, 19913, 3555, 9566, 29538, 2423, 39184, 8280, 14058, 8032, 2655, 25957, 1211, 24497], "avg_logprob": -0.20885416944821675, "compression_ratio": 1.6727272727272726, "no_speech_prob": 0.0, "words": [{"start": 1233.85, "end": 1234.19, "word": "لأن", "probability": 0.861083984375}, {"start": 1234.19, "end": 1234.47, "word": " انت", "probability": 0.58941650390625}, {"start": 1234.47, "end": 1234.81, "word": " بتكون", "probability": 0.73486328125}, {"start": 1234.81, "end": 1235.29, "word": " ماكن", 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"word": " سنة", "probability": 0.9684244791666666}, {"start": 1284.06, "end": 1284.26, "word": " لما", "probability": 0.895751953125}, {"start": 1284.26, "end": 1284.52, "word": " تيجي", "probability": 0.9818115234375}, {"start": 1284.52, "end": 1284.96, "word": " تسحب", "probability": 0.9658203125}, {"start": 1284.96, "end": 1285.34, "word": " blood", "probability": 0.84130859375}, {"start": 1285.34, "end": 1286.02, "word": " يعني", "probability": 0.8916015625}, {"start": 1286.02, "end": 1286.48, "word": " بربط", "probability": 0.9739583333333334}, {"start": 1286.48, "end": 1287.22, "word": " الـtourniquet", "probability": 0.9222237723214286}, {"start": 1287.22, "end": 1287.4, "word": " و", "probability": 0.54931640625}, {"start": 1287.4, "end": 1287.96, "word": " بعدين", "probability": 0.875}, {"start": 1287.96, "end": 1288.46, "word": " بروح", "probability": 0.99169921875}, {"start": 1288.46, "end": 1289.04, "word": " بجيب", "probability": 0.992919921875}, {"start": 1289.04, "end": 1290.18, "word": " ال", "probability": 0.430419921875}, {"start": 1290.18, "end": 1290.66, "word": " needle", "probability": 0.8525390625}, {"start": 1290.66, "end": 1290.94, "word": " و", "probability": 0.6318359375}, {"start": 1290.94, "end": 1291.8, "word": " السرنج", "probability": 0.7891357421875}, {"start": 1291.8, "end": 1291.94, "word": " و", "probability": 0.97802734375}, {"start": 1291.94, "end": 1292.58, "word": " الكحول", "probability": 0.9703776041666666}, {"start": 1292.58, "end": 1292.98, "word": " و", "probability": 0.95556640625}, {"start": 1292.98, "end": 1293.68, "word": " السواب", "probability": 0.7775065104166666}, {"start": 1293.68, "end": 1293.84, "word": " و", "probability": 0.95947265625}, {"start": 1293.84, "end": 1294.28, "word": " أجهز", "probability": 0.9451904296875}, {"start": 1294.28, "end": 1294.8, "word": " أغراضي", "probability": 0.89140625}, {"start": 1294.8, "end": 1295.06, "word": " و", "probability": 0.89404296875}, {"start": 1295.06, "end": 1295.66, "word": " الـtourniquet", "probability": 0.9124581473214286}, {"start": 1295.66, "end": 1296.12, "word": " مربوط", "probability": 0.9781494140625}, {"start": 1296.12, "end": 1296.3, "word": " له", "probability": 0.51220703125}, {"start": 1296.3, "end": 1296.62, "word": " عشر", "probability": 0.849365234375}, {"start": 1296.62, "end": 1297.04, "word": " دقايق", "probability": 0.856689453125}, {"start": 1297.04, "end": 1297.3, "word": " قبل", "probability": 0.946533203125}, {"start": 1297.3, "end": 1297.76, "word": " السحب", "probability": 0.9601236979166666}, {"start": 1297.76, "end": 1298.16, "word": " هذا", "probability": 0.58935546875}, {"start": 1298.16, "end": 1298.6, "word": " غلط", "probability": 0.984375}, {"start": 1298.6, "end": 1298.8, "word": " هذا", "probability": 0.48583984375}, {"start": 1298.8, "end": 1298.98, "word": " في", "probability": 0.98583984375}, {"start": 1298.98, "end": 1299.2, "word": " أي", "probability": 0.8564453125}, {"start": 1299.2, "end": 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"probability": 0.7039794921875}, {"start": 1306.64, "end": 1307.4, "word": " راطة", "probability": 0.8243815104166666}, {"start": 1307.4, "end": 1307.7, "word": " الـ", "probability": 0.892578125}, {"start": 1307.7, "end": 1308.22, "word": " Tourniquet", "probability": 0.95849609375}, {"start": 1308.22, "end": 1308.94, "word": " هذه", "probability": 0.59521484375}, {"start": 1308.94, "end": 1309.48, "word": " الحالة", "probability": 0.9939778645833334}, {"start": 1309.48, "end": 1309.58, "word": " يا", "probability": 0.66943359375}, {"start": 1309.58, "end": 1310.14, "word": " جماعة", "probability": 0.9951171875}, {"start": 1310.14, "end": 1311.12, "word": " بتأدي", "probability": 0.70947265625}, {"start": 1311.12, "end": 1311.5, "word": " إلى", "probability": 0.95361328125}, {"start": 1311.5, "end": 1311.86, "word": " لو", "probability": 0.90234375}, {"start": 1311.86, "end": 1312.2, "word": " انت", "probability": 0.644775390625}, {"start": 1312.2, "end": 1312.64, "word": " تركت", 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نفسه اللي هحط فيه الـ needle، هيكون فيه بروتينات تحت، يعني هيكون فيه مليان بروتينات متركزة، تمام؟ إذن بدنا نتجنب الـ venoestasis، تمام؟", "tokens": [2655, 9566, 1211, 3615, 16490, 9640, 7435, 25724, 38251, 12399, 46811, 10943, 22807, 37893, 16490, 9640, 7435, 25724, 38251, 37495, 22653, 4724, 23557, 11933, 5016, 8315, 8717, 8592, 38688, 11296, 12399, 6055, 9566, 1211, 3615, 37495, 22653, 15844, 14739, 3794, 7435, 3660, 25724, 38251, 12399, 46599, 6027, 2655, 6027, 1829, 2423, 13063, 25708, 8717, 36178, 3224, 13672, 1829, 8032, 5016, 9566, 8978, 3224, 2423, 39184, 11037, 12399, 39896, 30544, 8978, 3224, 4724, 32887, 2655, 9957, 9307, 6055, 33753, 12399, 37495, 22653, 39896, 30544, 8978, 3224, 3714, 20292, 7649, 4724, 32887, 2655, 9957, 9307, 44650, 31747, 11622, 3660, 12399, 46811, 10943, 22807, 11933, 8848, 1863, 47525, 8315, 8717, 2655, 7435, 1863, 3555, 2423, 39184, 6138, 78, 377, 26632, 12399, 46811, 10943, 22807], "avg_logprob": -0.1589395427068726, "compression_ratio": 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0.4306640625}, {"start": 1459.75, "end": 1460.23, "word": " و", "probability": 0.45556640625}, {"start": 1460.23, "end": 1460.57, "word": " بقرأ", "probability": 0.939697265625}, {"start": 1460.57, "end": 1460.75, "word": " ال", "probability": 0.57421875}, {"start": 1460.75, "end": 1461.09, "word": " sample", "probability": 0.89453125}, {"start": 1461.09, "end": 1461.35, "word": " و", "probability": 0.9130859375}, {"start": 1461.35, "end": 1461.85, "word": " باخد", "probability": 0.9674479166666666}, {"start": 1461.85, "end": 1462.87, "word": " absorbance", "probability": 0.96826171875}, {"start": 1462.87, "end": 1463.17, "word": " له", "probability": 0.92822265625}, {"start": 1463.17, "end": 1463.63, "word": " ال", "probability": 0.91552734375}, {"start": 1463.63, "end": 1463.95, "word": " color", "probability": 0.74951171875}, {"start": 1463.95, "end": 1464.25, "word": " تبع", "probability": 0.9235026041666666}, {"start": 1464.25, "end": 1464.73, "word": " التفاعل", "probability": 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{"start": 1481.84, "end": 1482.54, "word": " موجودة", "probability": 0.9774169921875}, {"start": 1482.54, "end": 1483.26, "word": " بحط", "probability": 0.9562174479166666}, {"start": 1483.26, "end": 1483.94, "word": " الأرقام", "probability": 0.98974609375}, {"start": 1483.94, "end": 1484.76, "word": " وبجيب", "probability": 0.8802490234375}, {"start": 1484.76, "end": 1485.68, "word": " تركيز", "probability": 0.9322509765625}, {"start": 1485.68, "end": 1486.58, "word": " الألبوم", "probability": 0.73486328125}, {"start": 1486.58, "end": 1488.02, "word": " بيليجرام", "probability": 0.6916910807291666}, {"start": 1488.02, "end": 1488.62, "word": " per", "probability": 0.734375}, {"start": 1488.62, "end": 1489.7, "word": " deciliter", "probability": 0.6847330729166666}, {"start": 1489.7, "end": 1490.42, "word": " تمام؟", "probability": 0.8400065104166666}], "temperature": 1.0}, {"id": 72, "seek": 151959, "start": 1492.25, "end": 1519.59, "text": "هنا يا جماعة كاتبلكوا الـ Reference Range لـ الـ album الـ Adult اللي بيكون أعمارهم من 21 سنة ل 44 سنة عند المال بيكون 33 ل 61 gram per liter قلتلكوا لو بدّي gram per deciliter بجس 10 يعني 3.3 ل 6.1 gram per deciliter وعند ال woman", "tokens": [3224, 8315, 35186, 10874, 15042, 27884, 9122, 9307, 3555, 23275, 14407, 2423, 39184, 1300, 5158, 33778, 5296, 39184, 2423, 39184, 6030, 2423, 39184, 47987, 13672, 1829, 4724, 1829, 30544, 5551, 25957, 9640, 16095, 9154, 5080, 8608, 1863, 3660, 5296, 16408, 8608, 1863, 3660, 43242, 9673, 6027, 4724, 1829, 30544, 11816, 5296, 28294, 21353, 680, 2733, 12174, 1211, 2655, 23275, 14407, 45164, 47525, 11703, 1829, 21353, 680, 979, 388, 1681, 4724, 7435, 3794, 1266, 37495, 22653, 805, 13, 18, 5296, 1386, 13, 16, 21353, 680, 979, 388, 1681, 4032, 3615, 41260, 2423, 3059], "avg_logprob": -0.2338709709464863, "compression_ratio": 1.5673076923076923, "no_speech_prob": 0.0, "words": [{"start": 1492.25, "end": 1492.55, "word": "هنا", "probability": 0.845947265625}, {"start": 1492.55, "end": 1492.71, 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"word": " 10", "probability": 0.256591796875}, {"start": 1512.29, "end": 1513.19, "word": " يعني", "probability": 0.920654296875}, {"start": 1513.19, "end": 1513.63, "word": " 3", "probability": 0.89013671875}, {"start": 1513.63, "end": 1514.63, "word": ".3", "probability": 0.938720703125}, {"start": 1514.63, "end": 1515.17, "word": " ل", "probability": 0.88720703125}, {"start": 1515.17, "end": 1515.59, "word": " 6", "probability": 0.9287109375}, {"start": 1515.59, "end": 1516.59, "word": ".1", "probability": 0.996337890625}, {"start": 1516.59, "end": 1517.31, "word": " gram", "probability": 0.962890625}, {"start": 1517.31, "end": 1517.69, "word": " per", "probability": 0.955078125}, {"start": 1517.69, "end": 1518.51, "word": " deciliter", "probability": 0.8968098958333334}, {"start": 1518.51, "end": 1519.21, "word": " وعند", "probability": 0.8460286458333334}, {"start": 1519.21, "end": 1519.35, "word": " ال", "probability": 0.9921875}, {"start": 1519.35, "end": 1519.59, "word": " woman", "probability": 0.422119140625}], "temperature": 1.0}, {"id": 73, "seek": 152810, "start": 1519.96, "end": 1528.1, "text": "من 2.7 لـ 5.6 إجراء per deciliter تركيز الألبومان، تمام؟", "tokens": [27842, 568, 13, 22, 5296, 39184, 1025, 13, 21, 11933, 7435, 2288, 16606, 680, 979, 388, 1681, 6055, 31747, 1829, 11622, 16247, 46152, 20498, 7649, 12399, 46811, 10943, 22807], "avg_logprob": -0.2652343730131785, "compression_ratio": 0.9659090909090909, "no_speech_prob": 0.0, "words": [{"start": 1519.96, "end": 1520.24, "word": "من", "probability": 0.91650390625}, {"start": 1520.24, "end": 1520.64, "word": " 2", "probability": 0.95556640625}, {"start": 1520.64, "end": 1521.62, "word": ".7", "probability": 0.986328125}, {"start": 1521.62, "end": 1522.16, "word": " لـ", "probability": 0.813720703125}, {"start": 1522.16, "end": 1522.44, "word": " 5", "probability": 0.83837890625}, {"start": 1522.44, "end": 1523.44, "word": ".6", "probability": 0.996826171875}, {"start": 1523.44, "end": 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"temperature": 1.0}, {"id": 80, "seek": 169866, "start": 1671.48, "end": 1698.66, "text": "Note a urine microalbumin test is a test to detect very small levels of blood protein albumin in your urine هذا الفحص اسمه urine microalbumin test أو إله اسم آخر microalbumin urea test يستخدم للكشف عن ال albumin حتى لو كان تركيز هذا ال albumin very very small في ال urine", "tokens": [49250, 257, 27638, 4532, 304, 5559, 259, 1500, 307, 257, 1500, 281, 5531, 588, 1359, 4358, 295, 3390, 7944, 6030, 259, 294, 428, 27638, 23758, 27188, 5016, 9381, 24525, 2304, 3224, 27638, 4532, 304, 5559, 259, 1500, 34051, 11933, 43761, 24525, 2304, 19753, 34740, 4532, 304, 5559, 259, 344, 12057, 1500, 7251, 14851, 9778, 40448, 5296, 23275, 8592, 5172, 18871, 2423, 6030, 259, 11331, 49975, 45164, 25961, 6055, 31747, 1829, 11622, 23758, 2423, 6030, 259, 588, 588, 1359, 8978, 2423, 27638], "avg_logprob": -0.17035060757543982, "compression_ratio": 1.655, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 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"probability": 0.158447265625}, {"start": 1771.33, "end": 1771.89, "word": " الفحص", "probability": 0.8585611979166666}, {"start": 1771.89, "end": 1772.37, "word": " to", "probability": 0.52783203125}, {"start": 1772.37, "end": 1772.83, "word": " detect", "probability": 0.97998046875}, {"start": 1772.83, "end": 1773.03, "word": " the", "probability": 0.56201171875}, {"start": 1773.03, "end": 1773.49, "word": " early", "probability": 0.96484375}, {"start": 1773.49, "end": 1774.03, "word": " signs", "probability": 0.87255859375}, {"start": 1774.03, "end": 1774.35, "word": " of", "probability": 0.9755859375}, {"start": 1774.35, "end": 1774.83, "word": " kidney", "probability": 0.91259765625}, {"start": 1774.83, "end": 1775.33, "word": " damage", "probability": 0.85791015625}, {"start": 1775.33, "end": 1775.71, "word": " in", "probability": 0.83154296875}, {"start": 1775.71, "end": 1776.11, "word": " people", "probability": 0.9755859375}, {"start": 1776.11, "end": 1776.35, "word": " who", "probability": 0.91259765625}, {"start": 1776.35, "end": 1776.81, "word": " are", "probability": 0.96142578125}, {"start": 1776.81, "end": 1777.21, "word": " at", "probability": 0.97900390625}, {"start": 1777.21, "end": 1777.61, "word": " risk", "probability": 0.8720703125}, {"start": 1777.61, "end": 1777.93, "word": " of", "probability": 0.97998046875}, {"start": 1777.93, "end": 1778.49, "word": " developing", "probability": 0.87158203125}, {"start": 1778.49, "end": 1779.03, "word": " kidney", "probability": 0.95703125}, {"start": 1779.03, "end": 1779.51, "word": " disease", "probability": 0.91357421875}, {"start": 1779.51, "end": 1780.55, "word": " أحيانًا", "probability": 0.8736979166666666}, {"start": 1780.55, "end": 1780.69, "word": " يا", "probability": 0.845703125}, {"start": 1780.69, "end": 1781.19, "word": " جماعة", "probability": 0.9949544270833334}, {"start": 1781.19, "end": 1781.63, "word": " هذا", "probability": 0.7236328125}, {"start": 1781.63, "end": 1782.11, "word": " الفحص", "probability": 0.9827473958333334}, {"start": 1782.11, "end": 1782.61, "word": " كتير", "probability": 0.9173177083333334}, {"start": 1782.61, "end": 1783.03, "word": " مهم", "probability": 0.994873046875}, {"start": 1783.03, "end": 1784.03, "word": " لمرضى", "probability": 0.869140625}, {"start": 1784.03, "end": 1784.79, "word": " السكري", "probability": 0.8736979166666666}, {"start": 1784.79, "end": 1785.51, "word": " بين", "probability": 0.71435546875}, {"start": 1785.51, "end": 1785.91, "word": " فترة", "probability": 0.9879557291666666}, {"start": 1785.91, "end": 1786.41, "word": " وفترة", "probability": 0.968017578125}, {"start": 1786.41, "end": 1787.11, "word": " أعملهم", "probability": 0.8944091796875}, {"start": 1787.11, "end": 1787.55, "word": " إياه", "probability": 0.8479817708333334}, {"start": 1787.55, "end": 1788.15, "word": " لأن", "probability": 0.865478515625}, {"start": 1788.15, "end": 1788.65, "word": " حكينا", "probability": 0.8660888671875}, {"start": 1788.65, "end": 1788.99, "word": " بيصير", "probability": 0.923583984375}, {"start": 1788.99, "end": 1789.25, "word": " عندهم", "probability": 0.99560546875}, {"start": 1789.25, "end": 1790.27, "word": " مضاعفات", "probability": 0.98876953125}, {"start": 1790.27, "end": 1790.95, "word": " ومن", "probability": 0.93994140625}, {"start": 1790.95, "end": 1791.87, "word": " المضاعفات", "probability": 0.99375}, {"start": 1791.87, "end": 1792.15, "word": " الـ", "probability": 0.86865234375}, {"start": 1792.15, "end": 1792.77, "word": " nephropathy", "probability": 0.7818603515625}, {"start": 1792.77, "end": 1793.47, "word": " مشاكل", "probability": 0.97021484375}, {"start": 1793.47, "end": 1793.65, "word": " في", "probability": 0.93798828125}, {"start": 1793.65, "end": 1794.19, "word": " النفران", "probability": 0.8939208984375}, {"start": 1794.19, "end": 1794.41, "word": " في", "probability": 0.58251953125}, {"start": 1794.41, "end": 1794.91, "word": " الكلة", "probability": 0.6551106770833334}, {"start": 1794.91, "end": 1795.73, "word": " فتبدأ", "probability": 0.9398193359375}, {"start": 1795.73, "end": 1796.09, "word": " الكلة", "probability": 0.92529296875}, {"start": 1796.09, "end": 1796.69, "word": " تسرب", "probability": 0.9420572916666666}, {"start": 1796.69, "end": 1797.13, "word": " عندهم", "probability": 0.991455078125}, {"start": 1797.13, "end": 1797.33, "word": " ال", "probability": 0.87841796875}, {"start": 1797.33, "end": 1797.75, "word": " albumin", "probability": 0.672119140625}], "temperature": 1.0}, {"id": 85, "seek": 182040, "start": 1797.86, "end": 1820.4, "text": "فأنا بدي أعمل detection early بدي أعمل كشف مبكر عن الخلل اللي بدي يصيب الكلة يعني أول ما الكلة تبدأ تنزل ألبما بدي أكشف بسرعة هذه المشكلة عشان ألحق المريض أعطيه علاج قبل ما نوصل لمراحل يصير عنده الفشل الكلوي كامل، تمام؟", "tokens": [5172, 10721, 8315, 4724, 16254, 5551, 25957, 1211, 17784, 2440, 4724, 16254, 5551, 25957, 1211, 9122, 8592, 5172, 3714, 3555, 37983, 18871, 33962, 1211, 1211, 13672, 1829, 4724, 16254, 7251, 9381, 1829, 3555, 2423, 28820, 3660, 37495, 22653, 5551, 12610, 19446, 2423, 28820, 3660, 6055, 44510, 10721, 6055, 1863, 11622, 1211, 5551, 46152, 15042, 4724, 16254, 5551, 4117, 8592, 5172, 4724, 3794, 2288, 27884, 29538, 9673, 8592, 28820, 3660, 6225, 8592, 7649, 5551, 1211, 5016, 4587, 9673, 16572, 11242, 5551, 3615, 9566, 1829, 3224, 11203, 26108, 12174, 36150, 19446, 8717, 2407, 36520, 5296, 29973, 39319, 1211, 7251, 9381, 13546, 43242, 3224, 27188, 8592, 1211, 33251, 1211, 45865, 9122, 10943, 1211, 12399, 46811, 10943, 22807], "avg_logprob": -0.11657608540161796, "compression_ratio": 1.7649769585253456, "no_speech_prob": 5.960464477539062e-07, "words": [{"start": 1797.86, "end": 1798.66, "word": "فأنا", "probability": 0.880859375}, {"start": 1798.66, "end": 1799.02, "word": " بدي", "probability": 0.779052734375}, {"start": 1799.02, "end": 1799.52, "word": " أعمل", "probability": 0.9754231770833334}, {"start": 1799.52, "end": 1800.22, "word": " detection", "probability": 0.5927734375}, {"start": 1800.22, "end": 1801.34, "word": " early", "probability": 0.576171875}, {"start": 1801.34, "end": 1801.72, "word": " بدي", "probability": 0.772216796875}, {"start": 1801.72, "end": 1802.14, "word": " أعمل", "probability": 0.9860026041666666}, {"start": 1802.14, "end": 1802.64, "word": " كشف", "probability": 0.9523111979166666}, {"start": 1802.64, "end": 1803.5, "word": " مبكر", "probability": 0.91845703125}, {"start": 1803.5, "end": 1804.34, "word": " عن", "probability": 0.98583984375}, {"start": 1804.34, "end": 1805.18, "word": " الخلل", "probability": 0.9763997395833334}, {"start": 1805.18, "end": 1805.34, "word": " اللي", "probability": 0.9501953125}, {"start": 1805.34, "end": 1805.58, "word": " بدي", "probability": 0.931640625}, {"start": 1805.58, "end": 1805.88, "word": " يصيب", "probability": 0.953857421875}, {"start": 1805.88, "end": 1806.18, "word": " الكلة", "probability": 0.718017578125}, {"start": 1806.18, "end": 1806.42, "word": " يعني", "probability": 0.8447265625}, {"start": 1806.42, "end": 1806.9, "word": " أول", "probability": 0.9375}, {"start": 1806.9, "end": 1807.08, "word": " ما", "probability": 0.68310546875}, {"start": 1807.08, "end": 1807.44, "word": " الكلة", "probability": 0.91796875}, {"start": 1807.44, "end": 1807.88, "word": " تبدأ", "probability": 0.9469401041666666}, {"start": 1807.88, "end": 1808.52, "word": " تنزل", "probability": 0.95458984375}, {"start": 1808.52, "end": 1809.1, "word": " ألبما", "probability": 0.7135416666666666}, {"start": 1809.1, "end": 1809.76, "word": " بدي", "probability": 0.83154296875}, {"start": 1809.76, "end": 1810.28, "word": " أكشف", "probability": 0.982177734375}, {"start": 1810.28, "end": 1810.8, "word": " بسرعة", "probability": 0.9896240234375}, {"start": 1810.8, "end": 1811.24, "word": " هذه", "probability": 0.41748046875}, {"start": 1811.24, "end": 1812.36, "word": " المشكلة", "probability": 0.996826171875}, {"start": 1812.36, "end": 1813.02, "word": " عشان", "probability": 0.9767252604166666}, {"start": 1813.02, "end": 1813.64, "word": " ألحق", "probability": 0.9217529296875}, {"start": 1813.64, "end": 1814.1, "word": " المريض", "probability": 0.9742838541666666}, {"start": 1814.1, "end": 1814.58, "word": " أعطيه", "probability": 0.93095703125}, {"start": 1814.58, "end": 1815.06, "word": " علاج", "probability": 0.9814453125}, {"start": 1815.06, "end": 1815.86, "word": " قبل", "probability": 0.90478515625}, {"start": 1815.86, "end": 1816.02, "word": " ما", "probability": 0.927734375}, {"start": 1816.02, "end": 1816.5, "word": " نوصل", "probability": 0.9908854166666666}, {"start": 1816.5, "end": 1817.42, "word": " لمراحل", "probability": 0.8597412109375}, {"start": 1817.42, "end": 1817.7, "word": " يصير", "probability": 0.9754231770833334}, {"start": 1817.7, "end": 1817.98, "word": " عنده", "probability": 0.9765625}, {"start": 1817.98, "end": 1818.34, "word": " الفشل", "probability": 0.8810221354166666}, {"start": 1818.34, "end": 1818.86, "word": " الكلوي", "probability": 0.8160807291666666}, {"start": 1818.86, "end": 1819.76, "word": " كامل،", "probability": 0.8836669921875}, {"start": 1819.76, "end": 1820.4, "word": " تمام؟", "probability": 0.9034830729166666}], "temperature": 1.0}, {"id": 86, "seek": 183782, "start": 1821.88, "end": 1837.82, "text": "فاحنا مهم الي عشان Early Science نكشف كشف مبكر عن الألبوم اللي موجود في الـUrine عشان نمنع الـComplication التم، تمام؟ يعطيكوا العافية", "tokens": [5172, 39319, 8315, 3714, 16095, 45595, 6225, 8592, 7649, 18344, 8976, 8717, 4117, 8592, 5172, 9122, 8592, 5172, 3714, 3555, 37983, 18871, 16247, 46152, 20498, 13672, 1829, 3714, 29245, 23328, 8978, 2423, 39184, 52, 15140, 6225, 8592, 7649, 8717, 27842, 3615, 2423, 39184, 14627, 4770, 399, 16712, 2304, 12399, 46811, 10943, 22807, 37495, 9566, 1829, 4117, 14407, 18863, 31845, 10632], "avg_logprob": -0.20811988193480696, "compression_ratio": 1.345679012345679, "no_speech_prob": 0.0, "words": [{"start": 1821.8799999999999, "end": 1823.12, "word": "فاحنا", "probability": 0.83251953125}, {"start": 1823.12, "end": 1823.58, "word": " مهم", "probability": 0.91552734375}, {"start": 1823.58, "end": 1823.9, "word": " الي", "probability": 0.08905029296875}, {"start": 1823.9, "end": 1824.84, "word": " عشان", "probability": 0.9248046875}, {"start": 1824.84, "end": 1825.56, "word": " Early", "probability": 0.6748046875}, {"start": 1825.56, "end": 1826.36, "word": " Science", "probability": 0.72998046875}, {"start": 1826.36, "end": 1826.96, "word": " نكشف", "probability": 0.955078125}, {"start": 1826.96, "end": 1827.32, "word": " كشف", "probability": 0.8738606770833334}, {"start": 1827.32, "end": 1827.94, "word": " مبكر", "probability": 0.9391276041666666}, {"start": 1827.94, "end": 1828.54, "word": " عن", "probability": 0.953125}, {"start": 1828.54, "end": 1829.2, "word": " الألبوم", "probability": 0.5515950520833334}, {"start": 1829.2, "end": 1829.58, "word": " اللي", "probability": 0.83544921875}, {"start": 1829.58, "end": 1830.08, "word": " موجود", "probability": 0.98095703125}, {"start": 1830.08, "end": 1830.34, "word": " في", "probability": 0.98828125}, {"start": 1830.34, "end": 1831.14, "word": " الـUrine", "probability": 0.7730712890625}, {"start": 1831.14, "end": 1831.88, "word": " عشان", "probability": 0.9736328125}, {"start": 1831.88, "end": 1832.5, "word": " نمنع", "probability": 0.9886067708333334}, {"start": 1832.5, "end": 1833.78, "word": " الـComplication", "probability": 0.9234375}, {"start": 1833.78, "end": 1835.04, "word": " التم،", "probability": 0.6258138020833334}, {"start": 1835.04, "end": 1836.92, "word": " تمام؟", "probability": 0.95849609375}, {"start": 1836.92, "end": 1837.38, "word": " يعطيكوا", "probability": 0.741796875}, {"start": 1837.38, "end": 1837.82, "word": " العافية", "probability": 0.9830729166666666}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 1838.8346875, "duration_after_vad": 1797.202499999997}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/1pa7lQ4WsSQ.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/1pa7lQ4WsSQ.srt
new file mode 100644
index 0000000000000000000000000000000000000000..768423d2b3f2ad49692ecb88a1ee87965d9a7141
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/1pa7lQ4WsSQ.srt
@@ -0,0 +1,2025 @@
+1
+00:00:00,810 --> 00:00:04,290
+السلام عليكم ورحمة الله وبركاته، يعطيكم العافية
+
+2
+00:00:04,290 --> 00:00:08,710
+جميعًا إن شاء الله، محاضرتنا اليوم بعنوان «جلوكوز
+
+3
+00:00:08,710 --> 00:00:14,830
+تستأنف... نبدأ بـ Introduction بسيطة. جلوكوز is a
+
+4
+00:00:14,830 --> 00:00:18,790
+monosaccharide found in fruits and also derived
+
+5
+00:00:18,790 --> 00:00:22,670
+from the breakdown of carbohydrates in the diet
+
+6
+00:00:22,670 --> 00:00:27,090
+and the conversion of glycogen by the liver. بحكي لي إن
+
+7
+00:00:27,090 --> 00:00:32,410
+الجلوكوز هو عبارة عن سكر أحادي موجود في fruits،
+
+8
+00:00:32,410 --> 00:00:37,290
+في الفواكه، يعني لو احنا تناولنا fruits، معنى
+
+9
+00:00:37,290 --> 00:00:43,410
+الكلام إحنا بنأكل أو بنتناول الجلوكوز. المصدر
+
+10
+00:00:43,410 --> 00:00:48,370
+الأساسي للجلوكوز هو الـ diet، هو الأكل، وبالأخص إذا
+
+11
+00:00:48,370 --> 00:00:53,030
+أكلنا carbohydrates. إذا المصدر الأساسي لسكر
+
+12
+00:00:53,030 --> 00:00:58,270
+الجلوكوز هو أن نَتناول أكلات، وبالأخص الـ
+
+13
+00:00:58,270 --> 00:01:04,970
+carbohydrates.  أيضًا، في مصدر آخر للجلوكوز، أنه لما
+
+14
+00:01:04,970 --> 00:01:11,930
+الإنسان يأكل أكلات، جسمه مليء بالسكر، طبعًا، هذه الزيادة
+
+15
+00:01:11,930 --> 00:01:17,740
+في السكر في الدم ستزيد، فماذا يحدث للجسم؟ يصبح الجسم
+
+16
+00:01:17,740 --> 00:01:24,880
+وبالأخص الكبد (liver)، يخزن السكر الفائض، تمام؟ يخزنه
+
+17
+00:01:24,880 --> 00:01:30,900
+على شكل جليكوجين. إذا الجلوكوز هو سكر أحادي، بشكل
+
+18
+00:01:30,900 --> 00:01:36,360
+أساسي، له مصدرين: المصدر الأول والأهم أنه نَحصل عليه
+
+19
+00:01:36,360 --> 00:01:41,420
+من الـ diet، من الأكل، وبالأخص الكربوهيدرات. المصدر
+
+20
+00:01:41,420 --> 00:01:46,440
+الثاني، أنه بعد ما أكلنا، الفائض من السكر في الجسم
+
+21
+00:01:46,440 --> 00:01:52,040
+يُخزّن على شكل جليكوجين داخل الـ liver لوقت
+
+22
+00:01:52,040 --> 00:01:58,300
+الحاجة، تمام؟ نقطة ثانية: جلوكوز is the body's main
+
+23
+00:01:58,300 --> 00:02:03,580
+source for cellular energy and brain function. يُعتبر السكر
+
+24
+00:02:03,580 --> 00:02:09,040
+هو المصدر الأساسي للطاقة في الجسم، يعني خلايا الجسم
+
+25
+00:02:09,040 --> 00:02:14,430
+عشان تشتغل، بدها طاقة، بدها energy، تمام؟ وهذه
+
+26
+00:02:14,430 --> 00:02:18,730
+الطاقة من أين تحصل عليها الخلايا؟ من تناولنا
+
+27
+00:02:18,730 --> 00:02:24,310
+للجلوكوز، للسكر، ومن ضمن هذه الخلايا، خلايا الدماغ
+
+28
+00:02:24,310 --> 00:02:28,790
+وجميع خلايا الجسم بحاجة إلى طاقة، هذه الطاقة مصدرها
+
+29
+00:02:28,790 --> 00:02:35,040
+تناول السكر.  Glucose level in the body is regulated by
+
+30
+00:02:35,040 --> 00:02:39,680
+insulin, because insulin lowers the glucose level, and
+
+31
+00:02:39,680 --> 00:02:44,320
+glucagon, adrenaline, and cortisol cause elevation of
+
+32
+00:02:44,320 --> 00:02:50,020
+the glucose level. بيحكي لي هنا: مستوى السكر عند
+
+33
+00:02:50,020 --> 00:02:54,420
+الإنسان السليم، يفترض دائمًا في حالة balance، في حالة
+
+34
+00:02:54,420 --> 00:02:59,960
+توازن، تمام؟ ولازم مستوى السكر في الجسم، بميكانيزم معين،
+
+35
+00:02:59,960 --> 00:03:05,390
+يحافظ عليه، تمام؟  نحن جميعًا نعرف أن السكر، لو
+
+36
+00:03:05,390 --> 00:03:09,230
+أردنا أن نجري فحص السكر، النسبة الطبيعية التي يجب
+
+37
+00:03:09,230 --> 00:03:14,430
+أن تكون ما بين 70 إلى 110 milligram per deciliter. ممنوع
+
+38
+00:03:14,430 --> 00:03:20,790
+أن يزيد أو يقل. طيب، لو مستوى السكر زاد عن 110، يعني أنتَ
+
+39
+00:03:20,790 --> 00:03:26,150
+أكلتَ carbohydrates كثيرة، ماذا سيفعل جسمك؟ كردة فعل
+
+40
+00:03:26,150 --> 00:03:31,930
+طبيعية، يتم إفراز هرمون الإنسولين. هرمون الإنسولين
+
+41
+00:03:31,930 --> 00:03:37,930
+يُخفض مستوى السكر في الدم. إذا هرمون الإنسولين يتم
+
+42
+00:03:37,930 --> 00:03:42,710
+إفرازه إذا زاد مستوى السكر في الدم عن الوضع
+
+43
+00:03:42,710 --> 00:03:46,850
+الطبيعي، يأتي الإنسولين ويأخذ هذا السكر الموجود في
+
+44
+00:03:46,850 --> 00:03:53,250
+الدم، ويبدأ يدخله داخل الخلايا، وتخزن هذه السكريات في
+
+45
+00:03:53,250 --> 00:03:57,120
+الخلايا. الخلايا، يا إما تخزن، أو الخلايا تستخدمه
+
+46
+00:03:57,120 --> 00:04:03,620
+في عملياتها الحيوية. لكن على سبيل المثال، والعكس، أنه
+
+47
+00:04:04,280 --> 00:04:09,800
+لو لسبب ما حدث عندنا انخفاض في مستوى السكر، انخفض
+
+48
+00:04:09,800 --> 00:04:13,940
+أقل من 70، لربما هذا الشخص لا يأكل سكريات، لا
+
+49
+00:04:13,940 --> 00:04:17,820
+يأكل carbohydrates، انخفض عنده، ماذا يحدث؟
+
+50
+00:04:17,820 --> 00:04:22,380
+نتيجة انخفاض السكر، الجسم يقوم بإفراز هرمونات
+
+51
+00:04:22,380 --> 00:04:27,680
+الـ glucagon، والـ adrenaline، والـ cortisol. هذه الثلاثة
+
+52
+00:04:27,680 --> 00:04:33,480
+هرمونات تُساهم في ارتفاع مستوى السكر في الدم. تحسس
+
+53
+00:04:33,480 --> 00:04:39,300
+بانخفاض، ماذا يحدث؟ ترفع مستوى السكر في
+
+54
+00:04:39,300 --> 00:04:43,180
+الدم، طبعًا بميكانيزمات معينة، ستأخذونها عندما تأخذون
+
+55
+00:04:43,180 --> 00:04:47,360
+دورة الهرمونات. The various disorders in
+
+56
+00:04:47,360 --> 00:04:50,960
+carbohydrate metabolism may be grouped into
+
+57
+00:04:50,960 --> 00:04:56,120
+several categories, dependent primarily on
+
+58
+00:04:56,120 --> 00:05:00,000
+laboratory findings. بيحكي لي هنا أن الـ
+
+59
+00:05:00,000 --> 00:05:04,000
+carbohydrate metabolism، العمليات الخاصة بالسكر،
+
+60
+00:05:04,000 --> 00:05:08,900
+وتنظيم السكر، ممكن يحدث فيها disorder، يحدث فيها
+
+61
+00:05:08,900 --> 00:05:13,460
+مشاكل. عندي مشكلتان أساسيتان، شغلة اسمها
+
+62
+00:05:13,460 --> 00:05:17,320
+hyperglycemia، وشغلة اسمها hypoglycemia.
+
+63
+00:05:18,790 --> 00:05:23,430
+الـ hyperglycemia هي عبارة عن حالة مرضية، وتعريفها:
+
+64
+00:05:23,430 --> 00:05:29,130
+ارتفاع مستوى السكر في الدم، نسميه hyperglycemia.
+
+65
+00:05:29,130 --> 00:05:29,890
+الـ hyperglycemia هي عبارة عن حالة مرضية، وتعريفها:
+
+66
+00:05:29,890 --> 00:05:34,350
+الـ hyperglycemia هي عبارة عن حالة مرضية، وتعريفها:
+
+67
+00:05:34,350 --> 00:05:36,550
+ارتفاع مستوى السكر في الدم، نسميه hyperglycemia.
+
+68
+00:05:36,550 --> 00:05:37,050
+الـ hyperglycemia هي عبارة عن حالة مرضية، وتعريفها:
+
+69
+00:05:37,050 --> 00:05:38,790
+ارتفاع مستوى السكر في الدم، نسميه hyperglycemia.
+
+70
+00:05:38,790 --> 00:05:41,530
+الـ hyperglycemia هي عبارة عن حالة مرضية، وتعريفها:
+
+71
+00:05:41,530 --> 00:05:44,840
+hyperglycemia.  لكن عكسها، الـ hypoglycemia
+
+72
+00:05:44,840 --> 00:05:49,920
+هي انخفاض مستوى السكر في الدم. Thus, associated with
+
+73
+00:05:49,920 --> 00:05:54,300
+a decreased plasma glucose concentration. والحالتان
+
+74
+00:05:54,300 --> 00:05:59,530
+حالات مرضية. The most frequently encountered
+
+75
+00:05:59,530 --> 00:06:03,930
+disorder of carbohydrate metabolism is a high
+
+76
+00:06:03,930 --> 00:06:07,890
+blood glucose due to diabetes mellitus. بقول لي إن
+
+77
+00:06:07,890 --> 00:06:12,310
+الـ most frequent، الأكثر شيوعًا بين الناس، هي حالات
+
+78
+00:06:12,310 --> 00:06:16,890
+الـ hyperglycemia، هي حالات ارتفاع مستوى السكر في
+
+79
+00:06:16,890 --> 00:06:21,310
+الدم، التي هي مرض السكري، الـ diabetes mellitus. أكثر
+
+80
+00:06:21,310 --> 00:06:25,290
+من الـ hypoglycemia. الـ hypoglycemia موجودة، بس مش
+
+81
+00:06:25,290 --> 00:06:29,720
+كثيرة. Estimates of the glucose concentration in
+
+82
+00:06:29,720 --> 00:06:34,520
+blood are required to... يعني ما هو الهدف من أن الدكتور
+
+83
+00:06:34,520 --> 00:06:40,260
+يطلب فحص السكر لأي شخص؟ يعني لماذا يطلب فحص السكر؟
+
+84
+00:06:40,260 --> 00:06:46,650
+لثلاثة أسباب أساسية. أول شغلة: help in the diagnosis of
+
+85
+00:06:46,650 --> 00:06:52,510
+diabetes mellitus. والله، فحص السكر يساعدني في تشخيص: هل
+
+86
+00:06:52,510 --> 00:06:56,850
+هذا الشخص الذي أمامي لديه diabetes mellitus؟ لديه
+
+87
+00:06:56,850 --> 00:07:01,770
+مرض سكري، أم إنسان طبيعي، لا يعاني من السكر، صحيح أم لا؟
+
+88
+00:07:01,770 --> 00:07:05,790
+إذا كنا نشتبه في إصابة شخص ما بالسكري، ماذا نقول له؟ اذهب واجعل
+
+89
+00:07:05,790 --> 00:07:11,000
+فحص سكر، صحيح أم لا؟ الهدف الثاني: Management of
+
+90
+00:07:11,000 --> 00:07:16,580
+diabetes mellitus patients. متابعة مرضى السكري، طبعًا
+
+91
+00:07:16,580 --> 00:07:22,560
+مرض السكري شائع ومنتشر بيننا.  فأنا، مرضى السكري، تقريبًا
+
+92
+00:07:22,560 --> 00:07:26,000
+كل شهرين، كل ثلاثة شهور، تسمعون بهم يذهبون إلى العيادة
+
+93
+00:07:26,000 --> 00:07:30,460
+ويجري فحص السكر، ويجري فحص مخزون السكر، لكي
+
+94
+00:07:30,460 --> 00:07:36,220
+نتابع وضعهم، ونتابع حالتهم. أيضًا نجري الفحص لسبب
+
+95
+00:07:36,220 --> 00:07:40,160
+ثالث: "and monitoring of treatment in diabetes
+
+96
+00:07:40,160 --> 00:07:46,380
+mellitus patients".  نريد متابعة جرعة، آسف، نريد
+
+97
+00:07:46,380 --> 00:07:51,180
+متابعة جرعة الإنسولين التي يأخذها مرضى السكري.
+
+98
+00:07:51,180 --> 00:07:56,180
+نعرف أنه في المراحل المتأخرة من مرض السكري، يصبح
+
+99
+00:07:56,180 --> 00:08:00,440
+الشخص يأخذ إبر إنسولين. طيب، كيف نريد أن نعرف أن جرعة
+
+100
+00:08:00,440 --> 00:08:07,960
+الإنسولين مضبوطة أم لا؟ وهل هذه الجرعة جيدة أم لا؟
+
+101
+00:08:07,960 --> 00:08:13,760
+فنطلب، لكي نتابع جرعة الإنسولين، نطلب من المريض
+
+102
+00:08:13,760 --> 00:08:17,740
+الذي يعاني من السكري أن يُجري فحص السكر. لثلاثة أهداف: في
+
+103
+00:08:17,740 --> 00:08:23,470
+التشخيص (diagnosis)، وفي متابعة المريض، ومتابعة
+
+104
+00:08:23,470 --> 00:08:28,190
+أيضًا جرعة الإنسولين التي يأخذها، أو التي يأخذونها
+
+105
+00:08:28,190 --> 00:08:35,470
+مرضى السكري. Methods of Analysis: طرق التحليل الخاصة
+
+106
+00:08:35,470 --> 00:08:41,570
+بفحص السكر. هنا سنستعرض كيّتات السكر، و
+
+107
+00:08:41,570 --> 00:08:46,750
+والتفاعل (reaction) الخاص بالسكر.  يعني، ما هي الطريقة التي تعمل
+
+108
+00:08:46,750 --> 00:08:52,050
+بها الكيت؟ أول شغلة، in the past, the majority of
+
+109
+00:08:52,050 --> 00:08:55,550
+the quantitative tests for glucose determination
+
+110
+00:08:55,550 --> 00:09:00,310
+were dependent upon the oxidation of glucose by hot
+
+111
+00:09:00,310 --> 00:09:04,470
+alkaline copper solutions, or solutions of
+
+112
+00:09:04,470 --> 00:09:09,690
+potassium ferric cyanide.  بحكي لي: زمان، قديماً، كان
+
+113
+00:09:09,690 --> 00:09:14,690
+مبدأ الكيت، ومبدأ الرياجينت الخاص بالسكر، أنه
+
+114
+00:09:14,690 --> 00:09:19,750
+عندما أضع الرياجينت على السيروم الخاص بالمريض،
+
+115
+00:09:19,750 --> 00:09:24,750
+الرياجينت يقوم بعمل oxidation، بأكسدة السكر
+
+116
+00:09:24,750 --> 00:09:30,270
+الجلوكوز الموجود في سيروم المريض. وعملية
+
+117
+00:09:30,270 --> 00:09:37,660
+الأكسدة هذه تتطلب حرارة (heat)، وتتطلب أيضًا وجود
+
+118
+00:09:37,660 --> 00:09:43,320
+alkaline media. يعني الـ reagent، الـ pH الخاص به يجب
+
+119
+00:09:43,320 --> 00:09:49,340
+أن يكون قاعديًا. إذن بشكل عام، بيحكي لي: قديماً كان مبدأ
+
+120
+00:09:49,340 --> 00:09:54,560
+الفحص يعتمد على أن الرياجينت الخاص بالسكر، في المواد
+
+121
+00:09:54,560 --> 00:09:59,240
+إذا أُضيف إلى السيروم الخاص بالمريض، سيؤكسد السكر
+
+122
+00:09:59,240 --> 00:10:03,240
+الجلوكوز الموجود في السيروم. وعشان يصير فيه أكسدة،
+
+123
+00:10:03,240 --> 00:10:06,420
+يجب أن يكون الرياجينت الموجود في الكيت له
+
+124
+00:10:06,420 --> 00:10:12,140
+alkaline pH. وهذا يتطلب أيضًا، من المتطلبات، درجات
+
+125
+00:10:12,140 --> 00:10:18,790
+حرارة عالية.  الـ alkaline pH نوفره إذا كان موجودًا
+
+126
+00:10:18,790 --> 00:10:24,630
+داخل الرياجينت، الـ copper solution، أو محلول آخر
+
+127
+00:10:24,630 --> 00:10:28,690
+اسمه potassium ferric cyanide. هذه كلها مواد
+
+128
+00:10:28,690 --> 00:10:32,590
+كيميائية خاصة بالرياجينت، الـ alkaline pH،
+
+129
+00:10:32,590 --> 00:10:38,720
+القاعدي. هذه تم تغييرها، بمحاولة استخدام الـ orthotolidine
+
+130
+00:10:38,720 --> 00:10:43,200
+test، وبعدها بمحاولة استخدام الإنزيمات. بعد ذلك، هذه الطريقة
+
+131
+00:10:43,200 --> 00:10:48,200
+القديمة، وهذا الرياجينت، توقفت الشركات عن تصنيعه. فثاروا
+
+132
+00:10:48,200 --> 00:10:51,680
+ماذا؟ ثاروا واستخدموا طريقة أخرى، اسمها الـ
+
+133
+00:10:51,680 --> 00:10:56,680
+ortho-tolidine test.  نريد أن نفهم أن التفاعل الخاص
+
+134
+00:10:56,680 --> 00:11:01,760
+بالسكر كان يحتوي على مادة اسمها ortho-tolidine، عندما كنتُ
+
+135
+00:11:01,760 --> 00:11:06,600
+أضيفها على السيروم، تأتي على الجلوكوز، وترتبط به
+
+136
+00:11:06,600 --> 00:11:13,000
+الجلوكوز، وتعطي مادة ملونة، ونحن نقيس هذا اللون،
+
+137
+00:11:13,000 --> 00:11:18,360
+وهو الذي كان يعبر عن مستوى السكر. طيب، هذه الطريقة
+
+138
+00:11:18,360 --> 00:11:22,020
+الثانية، الـ ortho-tolidine test، لماذا توقفت الشركات عن
+
+139
+00:11:22,020 --> 00:11:26,320
+استخدامها؟ لأن مادة ortho-tolidine هذه الموجودة
+
+140
+00:11:26,320 --> 00:11:30,440
+في التفاعل الخاص بالسكر مادة dangerous، وتسبب
+
+141
+00:11:30,440 --> 00:11:35,630
+السرطان (cancer). لأنها من مشتقات البنزين. تخيل،
+
+142
+00:11:35,630 --> 00:11:41,090
+أنتَ تجري فحص سكر، فحص روتيني، ورياجينت السكر، أنتَ تريد
+
+143
+00:11:41,090 --> 00:11:44,250
+أن يكون هناك دائمًا احتكاك به بيدك، وقد لا تكونين ترتدين
+
+144
+00:11:44,250 --> 00:11:49,990
+قُفازات (gloves)، فممكن أن يُسبب سرطان الجلد (skin cancer).  لذلك
+
+145
+00:11:49,990 --> 00:11:54,450
+جاءت هذه الطريقة غير آمنة. فلنستبدلها
+
+146
+00:11:54,450 --> 00:11:58,690
+بالطريقة الثالثة، التي هي طريقة الـ enzyme method.
+
+147
+00:11:58,690 --> 00:12:03,610
+يعني، الرياجينت يكون فيه enzyme. هذا الـ enzyme
+
+148
+00:12:03,610 --> 00:12:08,450
+يتفاعل مع السكر الموجود في السيروم الخاص بالـ
+
+149
+00:12:08,450 --> 00:12:12,790
+patient. عندما نضعهما معًا، يعطيني لونًا،
+
+150
+00:12:12,790 --> 00:12:17,950
+وأنا أقيس هذا اللون عبر جهاز spectrophotometer.
+
+151
+00:12:18,580 --> 00:12:24,080
+جاءت طريقة الإنزيمات أفضل. أولاً: specific، متخصصة،
+
+152
+00:12:24,080 --> 00:12:31,360
+أحصل على إنزيم يتخصص، يرتبط فقط بالسكر، طبعًا. وطريقة
+
+153
+00:12:31,360 --> 00:12:36,660
+سريعة (quick)، بسرعة (quickly). و specificity، السرعة
+
+154
+00:12:36,790 --> 00:12:41,370
+والتخصصية عالية عند الإنزيمات، ولا تستهلك وقتًا
+
+155
+00:12:41,370 --> 00:12:45,390
+الفحص. وأيضًا، الإنزيمات، والمواد الموجودة في
+
+156
+00:12:45,390 --> 00:12:49,310
+الرياجينت، ليست dangerous، ليست خطرة، مثل الـ
+
+157
+00:12:49,310 --> 00:12:54,550
+ortho-tolidine. إذا الـ enzymatic methods give the
+
+158
+00:12:54,550 --> 00:12:59,310
+true glucose determination. تعطيني نسبة الجلوكوز
+
+159
+00:12:59,310 --> 00:13:02,830
+بشكل صحيح، because of the high specificity
+
+160
+00:13:02,830 --> 00:13:08,130
+للإنزيمات المتخصصة، of an enzyme for a particular
+
+161
+00:13:08,130 --> 00:13:11,770
+substrate, and doesn't consume time. والإنزيم
+
+162
+00:13:11,770 --> 00:13:16,190
+شئ سريع. other methods: طرق أخرى، تحتوي على مواد
+
+163
+00:13:16,190 --> 00:13:20,550
+خطرة (dangerous) على الجسم، مثل، على سبيل المثال، الـ ortho-tolidine.
+
+164
+00:13:20,550 --> 00:13:23,590
+مثل، على سبيل المثال، الـ ortho-tolidine.
+
+165
+00:13:25,510 --> 00:13:29,630
+هنا ملخص لكم طرق التحليل (Methods of Analysis)، طرق
+
+166
+00:13:29,630 --> 00:13:35,290
+التحليل الخاصة بكيّت السكر، بالرياجينت الخاص بالسكر، طبعًا.
+
+167
+00:13:35,290 --> 00:13:40,170
+أول شغلة، أول طريقة، هذه طريقة قديمة جدًا، توقفت
+
+168
+00:13:40,170 --> 00:13:45,570
+الشركات عن تصنيعها، تمامًا. توقفت الشركات عن تصنيع الكيت
+
+169
+00:13:45,570 --> 00:13:49,390
+الذي يعمل بهذه الطريقة، التي هي طريقة الـ
+
+170
+00:13:49,390 --> 00:13:53,170
+oxidation، الأكسدة، أو الـ reduction method، في الشريحة
+
+171
+00:13:53,170 --> 00:13:57,400
+السابقة، تحدثنا عن الأكسدة، لكن هنا كاتب الـ
+
+172
+00:13:57,400 --> 00:14:01,620
+reduction methods، طرق الاختزال. يعني، يكون فيه مواد
+
+173
+00:14:01,620 --> 00:14:05,480
+في الت
+
+223
+00:18:13,090 --> 00:18:17,750
+وفي وجود أنزيم آخر اسمه جلوكوز-6-فوسفات
+
+224
+00:18:17,750 --> 00:18:24,960
+Dehydrogenase، أعطوني مادة اسمها 6-gluconolactone
+
+225
+00:18:24,960 --> 00:18:32,000
+NADH + H+، هنا بتم قياس الـ NADH هذا
+
+226
+00:18:32,000 --> 00:18:37,080
+المركب، كلنا عارفين هذا المركب، بتم قياسه على
+
+227
+00:18:37,080 --> 00:18:42,780
+wavelength معروف و ثابت على طول موجي ثابت هو 340
+
+228
+00:18:42,780 --> 00:18:47,740
+نانومتر، كلنا عارفين أن الـ 340 هذا الـ
+
+229
+00:18:47,740 --> 00:18:54,160
+wavelength يقع في المنطقة فوق البنفسجية، الـ UV، الـ
+
+230
+00:18:54,160 --> 00:18:58,080
+Ultraviolet، يعني لما بدك تجيبي تعملي فحص السكر هنا
+
+231
+00:18:58,080 --> 00:19:02,660
+ما بتستخدمي الـ plastic cuvette العادية اللي
+
+232
+00:19:02,660 --> 00:19:08,960
+بنحطها في الجهاز، لأ، الـ cuvette بتكون زجاج، تمام؟ لأن
+
+233
+00:19:08,960 --> 00:19:15,580
+الـ 340 هذا wavelength موجود في منطقة فوق بنفسجية
+
+234
+00:19:15,580 --> 00:19:21,160
+في الـ UV، في الـ Ultraviolet، فبنقيس الـ NADH ونسبته
+
+235
+00:19:21,160 --> 00:19:27,380
+بتعبّر عن نسبة السكر، طبعاً هذه طريقة reference
+
+236
+00:19:27,380 --> 00:19:31,140
+method، هي الطريقة المرجعية على الرغم من أنها
+
+237
+00:19:31,140 --> 00:19:36,340
+الطريقة المرجعية، إلا أنه نادر استخدامها، كتير ما
+
+238
+00:19:36,340 --> 00:19:39,680
+بتشتغل بهذه الطريقة، لأنها طريقة، على الرغم من أنها
+
+239
+00:19:39,680 --> 00:19:46,300
+مرجعية، بدها متطلبات، بدها جهاز Spectrophotometer بيشتغل على
+
+240
+00:19:46,300 --> 00:19:50,600
+الكيوفيت تكون من الزجاج، مصنوعة من الزجاج، وغالية
+
+241
+00:19:50,600 --> 00:19:56,180
+كتير، اللمبة اللي بتطلع الشعاع تبع الـ wavelengths
+
+242
+00:19:56,180 --> 00:20:01,000
+اللي طوله 340 نانومتر، برضه هذه اللمبة اللي موجودة
+
+243
+00:20:01,000 --> 00:20:04,520
+في الـ Spectrophotometer برضه حاجتها غالية، يعني okay، طريقة
+
+244
+00:20:04,520 --> 00:20:08,740
+مرجعية لكن لا تستخدم، وبالنسبة للمعادلات يا جماعة
+
+245
+00:20:08,740 --> 00:20:14,550
+مش مطلوبة، بس بدنا نفهم المبدأ، تمام؟ الطريقة الثانية
+
+246
+00:20:14,550 --> 00:20:18,050
+فيه كتير أجهزة بتشتغل بهذه الطريقة، الـ Glucose
+
+247
+00:20:18,050 --> 00:20:22,590
+Dehydrogenase Method، يعني من اسم الطريقة بتفهم إن
+
+248
+00:20:22,590 --> 00:20:27,990
+الـ Reagent جواته إنزيم اسمه Glucose Dehydrogenase
+
+249
+00:20:27,990 --> 00:20:33,530
+يعني بتروحي، الجلوكوز اللي موجود في عينة الـ patient
+
+250
+00:20:33,530 --> 00:20:39,550
+في عينة المريض، في وجود الـ NAD ووجود إنزيم اللي
+
+251
+00:20:39,550 --> 00:20:43,110
+موجود في الـ Reagent، الـ Glucose Dehydrogenase
+
+252
+00:20:43,110 --> 00:20:47,630
+هيشتغل على السكر الموجود في عينة المريض ويعطيني مادة
+
+253
+00:20:47,630 --> 00:20:52,230
+Gluconolactone + NADH + H+، برضه
+
+254
+00:20:52,230 --> 00:20:58,710
+هنا بنقيس الـ NADH على 340، ومقداره يعبر عن مستوى
+
+255
+00:20:58,710 --> 00:21:02,670
+السكر في الدم، برضه هذه الطريقة كتير أجهزة ما بتشتغل
+
+256
+00:21:02,670 --> 00:21:07,520
+فيها، آخر طريقة، وهذه الطريقة الـ most common، الشائعة،
+
+257
+00:21:07,520 --> 00:21:13,720
+الـ popular، الأكثر انتشاراً، واللي شركتنا بتصنع الـ
+
+258
+00:21:13,720 --> 00:21:17,760
+reagent تبع السكر بهذه الطريقة، جلوكوز أوكسيديز
+
+259
+00:21:17,760 --> 00:21:22,140
+method، بدنا نفهم أن الـ reagent يحتوي على إنزيم
+
+260
+00:21:22,140 --> 00:21:27,300
+اسمه جلوكوز أوكسيديز، لما أضيف الـ reagent على عينة
+
+261
+00:21:27,300 --> 00:21:31,420
+الـ patient، هذا الإنزيم الـ oxidase هيعمل
+
+262
+00:21:31,420 --> 00:21:37,240
+oxidation، أكسدة للسكر اللي موجود في عينة المريض، وفي
+
+263
+00:21:37,240 --> 00:21:42,460
+الآخر يعطيني مركب، مادة ملونة، وإحنا بنقيس
+
+264
+00:21:42,460 --> 00:21:48,100
+اللون، وشدة اللون تعبر عن مستوى السكر، يعني لو
+
+265
+00:21:48,100 --> 00:21:53,880
+طلع اللون غامق كتير، نتيجة التفاعل، أنت حتجد أنك حطيت
+
+266
+00:21:53,880 --> 00:21:58,900
+الـ reagent على عينة المريض، لو ظهر لك مادة ملونة
+
+267
+00:21:58,900 --> 00:22:05,890
+ولونها غامق كتير، يعني بتحكي أكيد السكر يعني عالي
+
+268
+00:22:05,890 --> 00:22:10,030
+كتير، لو طلع اللون كويس طبيعي بتحكي أكيد السكر عند
+
+269
+00:22:10,030 --> 00:22:14,890
+هذا المريض طبيعي، إذن من شدة اللون أنا بشوف أو بقدر
+
+270
+00:22:14,890 --> 00:22:21,960
+أُقدر مستوى السكر، تمام؟ هذه الطريقة بيسموها طريقة
+
+271
+00:22:21,960 --> 00:22:26,000
+الـ Glucose Oxidase Method، تسمى باسم آخر، الـ
+
+272
+00:22:26,000 --> 00:22:30,180
+Trinder's Method، طريقة الـ Trinder's تعتمد على
+
+273
+00:22:30,180 --> 00:22:35,020
+إنزيم دايكروماتري، يعني الإنزيم بيتفاعل مع
+
+274
+00:22:35,020 --> 00:22:40,000
+السكر، بعطيني في الآخر دايكروماتري، لون دايكروماتري
+
+275
+00:22:40,000 --> 00:22:45,200
+ملون، بجي أقيس هذا اللون بجهاز الـ Spectrophotometer وبعطيني
+
+276
+00:22:45,200 --> 00:22:50,920
+Absorbance، وطريقة أخرى اسمها kinetic method، طريقة
+
+277
+00:22:50,920 --> 00:22:56,160
+حركية، هذه هنفهمها أكثر لما نأخذ شغل الإنزيمات
+
+278
+00:22:56,160 --> 00:23:01,140
+ونفحص الإنزيمات، تمام؟ بس المهم كتير أجهزة بتشتغل على
+
+279
+00:23:01,140 --> 00:23:07,810
+مبدأ الـ Trinder's method، enzyme dichlorometric، هل جيت
+
+280
+00:23:07,810 --> 00:23:11,570
+بدنا نعمل فحص السكر؟ إيش الـ Specimen Collection؟
+
+281
+00:23:11,570 --> 00:23:16,810
+إيش نوع العينة؟ العينة قد تكون Serum، البلازما is
+
+282
+00:23:16,810 --> 00:23:21,150
+suitable for samples، عادي، يا Serum يا بلازما
+
+283
+00:23:21,150 --> 00:23:25,570
+الـ whole blood، تجيبي لي دم كامل، تحكي لي اعملي عليه
+
+284
+00:23:25,570 --> 00:23:30,030
+فحص السكر، ما بينفعش، لازم أفصل هذا الدم وأطلع منه الـ
+
+285
+00:23:30,030 --> 00:23:33,990
+Serum والبلازما، والـ Serum والبلازما هما العينة،
+
+286
+00:23:33,990 --> 00:23:38,610
+تمام؟ أما whole blood مرفوض، والـ hemolysis يعني
+
+287
+00:23:38,610 --> 00:23:42,950
+لو جاءتك عينة hemolyzed برضه هذه rejected، مرفوضة،
+
+288
+00:23:42,950 --> 00:23:47,350
+are not recommended for use as a sample، يعني لا
+
+289
+00:23:47,350 --> 00:23:53,920
+يوصى باستخدامهم كعينة، تمام؟ الـ freshly drawn serum
+
+290
+00:23:53,920 --> 00:23:59,040
+is the preferred specimen، بيحكي لي أن أفضل عينة هي
+
+291
+00:23:59,040 --> 00:24:03,680
+الـ serum، تمام؟ لكن شو المسموح فيه؟ المسموح يا serum
+
+292
+00:24:03,680 --> 00:24:08,080
+يا بلازما، طيب، لو بلازما، إيش نوع الـ
+
+293
+00:24:08,080 --> 00:24:11,800
+anticoagulant اللي لازم أجمع فيه عينات الـ blood؟
+
+294
+00:24:11,800 --> 00:24:16,060
+بيقول لك يا إما EDTA يا هيبارين، مسموح فيهم، يا
+
+295
+00:24:16,060 --> 00:24:20,520
+EDTA يا هيبارين، طبعاً تجيك من الشركة الأنابيب
+
+296
+00:24:20,520 --> 00:24:23,140
+جاهزة، فيها EDTA، أنبوبة الـ EDTA أو أنبوبة
+
+297
+00:24:23,140 --> 00:24:28,520
+الـ هيبارين، كلكم عارفين، بيحكي لي يفضل أنا كأخصائي
+
+298
+00:24:28,520 --> 00:24:31,380
+التحاليل الطبية بعرف إن هذا الشخص بدي أعمل له فحص
+
+299
+00:24:31,380 --> 00:24:37,520
+سكر مثلاً، بجيب أنبوبة EDTA وبحط فوق الـ EDTA شغلة
+
+300
+00:24:37,520 --> 00:24:44,930
+اسمها glycolytic inhibitor، مثبتات لعملية الـ Glycolysis
+
+301
+00:24:44,930 --> 00:24:50,670
+وحنشوف ليش، تمام؟ ليش أنا بجيب الأنابيب
+
+302
+00:24:51,750 --> 00:24:56,610
+اللي فيها الـ EDTA أو الـ Heparin وبحط فيها
+
+303
+00:24:56,610 --> 00:25:02,950
+glycolytic inhibitor، مثبتات لعملية الـ Glycolysis، ليش
+
+304
+00:25:02,950 --> 00:25:06,250
+هذا العمل أنا بعمله، هنجيء في الـ slide الثانية،
+
+305
+00:25:06,250 --> 00:25:11,730
+هنشوف، بيقول لي إنه كيف ممكن أحفظ عينتي سواء Serum أو
+
+306
+00:25:11,730 --> 00:25:17,370
+Plasma، بتفصليهم، بتجيبي أنبوبة لحال، بتفصلي الـ Serum
+
+307
+00:25:17,370 --> 00:25:21,930
+لحال أو البلازما لحال، وبتخزني الـ Serum والبلازما
+
+308
+00:25:21,930 --> 00:25:27,930
+ممكن أخزنهم سبعة أيام يظلوا stable في الثلاجة من
+
+309
+00:25:27,930 --> 00:25:32,810
+2 إلى 8 درجات مئوية، أو ممكن أخليهم يومين
+
+310
+00:25:32,810 --> 00:25:36,890
+موجودين، متركين على الـ room temperature، على درجة
+
+311
+00:25:36,890 --> 00:25:41,790
+حرارة 20 إلى 25 درجة مئوية، برضه بيظل
+
+312
+00:25:41,790 --> 00:25:48,240
+الـ Serum والبلازما stable، تمام؟ هل جئت مثلاً، جاءني
+
+313
+00:25:48,240 --> 00:25:54,080
+مريض وبدي أعمل له فحص سكر مثلاً، بدي أجمع له Serum، بروح
+
+314
+00:25:54,080 --> 00:25:58,620
+أجيب أنابيب plane tube، ما فيها أي Anti-coagulant
+
+315
+00:25:58,620 --> 00:26:04,160
+اللي لون الغطاء تبعها أحمر، وقبل ما أحط الدم فيها
+
+316
+00:26:04,160 --> 00:26:09,680
+بروح أجيب مادة اسمها Sodium Fluoride، هذه المادة
+
+317
+00:26:09,680 --> 00:26:15,200
+تعتبر glycolytic inhibitor، هي مثبتة لعملية
+
+318
+00:26:15,200 --> 00:26:21,300
+الـ Glycolysis، بأخذ من هذه المادة 2 مليجرام، و
+
+319
+00:26:21,300 --> 00:26:26,300
+بحطها جوة الـ plane tube اللي بدي أجمع فيها الدم، و
+
+320
+00:26:26,300 --> 00:26:32,980
+بعدين بروح على المريض بسحب منه 1 مل دم، 1 مل blood، و
+
+321
+00:26:32,980 --> 00:26:37,720
+بحطها في هذه الأنبوبة، وبعمل mix منيح، وبروح بفصّلها
+
+322
+00:26:37,980 --> 00:26:44,060
+وبأطلّع الـ Serum منها، أو لو شخص بدي أجمع له بلازما
+
+323
+00:26:44,060 --> 00:26:48,880
+بروح أجيب أنابيب فيها Anticoagulant، إما EDTA
+
+324
+00:26:48,880 --> 00:26:54,180
+أو Heparin، وبرضه قبل ما أضيف الدم في هذه
+
+325
+00:26:54,180 --> 00:26:59,860
+الأنابيب، بروح أجيب 2 مليجرام من مادة الـ Sodium
+
+326
+00:26:59,860 --> 00:27:05,040
+Fluoride وبحطها في الأنابيب، وبعدين بروح أسحب blood
+
+327
+00:27:05,040 --> 00:27:10,720
+من المريض، 1 مل مثلاً، بنسحب منه وبنحطها، ونعمل mix
+
+328
+00:27:10,720 --> 00:27:16,260
+وبعدين بنروح نفصل البلازما، ليش أنا قبل ما أحط الدم
+
+329
+00:27:16,260 --> 00:27:21,320
+في الأنابيب، بروح أضيف مادة اسمها Sodium Fluoride،
+
+330
+00:27:21,320 --> 00:27:25,980
+هذه المادة تعتبر glycolytic inhibitor، مثبتة لعملية
+
+331
+00:27:25,980 --> 00:27:31,630
+الـ Glycolysis، The addition of 2 milligram من الـ
+
+332
+00:27:31,630 --> 00:27:37,850
+Sodium Fluoride لكل 1 مل blood to be collected
+
+333
+00:27:37,850 --> 00:27:42,770
+will prevent glycolysis، إضافة هذه المادة وبعد ذلك
+
+334
+00:27:42,770 --> 00:27:48,430
+بضيف الدم، وبعد ذلك بفصّل العينة، هذا يمنع عملية الـ
+
+335
+00:27:48,430 --> 00:27:55,270
+Glycolysis، العمليات الحيوية اللي بتقوم فيها خلايا
+
+336
+00:27:55,270 --> 00:27:59,340
+الدم الحمراء، هل جئت؟ طب ليش أنا بمنع عملية
+
+337
+00:27:59,340 --> 00:28:03,540
+الـ Glycolysis؟ هل جئت؟ بدي أطلب منكم شغلة، لما أنتم
+
+338
+00:28:03,540 --> 00:28:08,000
+تفصلوا عينة الدم، تمام؟ إيش بينزل تحت؟ بينزل تحت
+
+339
+00:28:08,000 --> 00:28:12,400
+الخلايا، الـ RBCs، الـ Platelets، الـ White Blood Cells، بينزل
+
+340
+00:28:12,400 --> 00:28:15,680
+الخلايا تحت، تمام؟ فوق إيش بيكون؟ فوق بيكون
+
+341
+00:28:15,680 --> 00:28:20,270
+الـ Serum أو البلازما، تمام؟ الـ Serum إيش فيه؟ فيه
+
+342
+00:28:20,270 --> 00:28:23,770
+المواد الكيميائية المهمة، الجلوكوز، فيه
+
+343
+00:28:23,770 --> 00:28:29,210
+البروتينات، فيه الإنزيمات، هل جئت؟ لو ظلّ الـ Serum
+
+344
+00:28:29,210 --> 00:28:33,690
+contact مع الخلايا، يعني أنت ما فصلت الـ Serum لحاله
+
+345
+00:28:33,690 --> 00:28:38,770
+في الـ tube لحالها، خليتيها العينة مفصولة، والـ RBCs
+
+346
+00:28:38,770 --> 00:28:43,310
+تحت، والـ Serum فوق، فوق بعض من غير فصل، إيش بدي
+
+347
+00:28:43,310 --> 00:28:47,630
+يصير؟ اللي بيصير إنه الخلايا الـ RBCs، خلايا حية
+
+348
+00:28:47,630 --> 00:28:52,030
+طول ما هي حية بدها تعمل Glycolysis، إيش يعني بدها
+
+349
+00:28:52,030 --> 00:28:56,370
+تعمل Glycolysis؟ يعني بدها تبدأ تسحب الجلوكوز من
+
+350
+00:28:56,370 --> 00:29:01,090
+الـ Serum، تبدأ، ما هي بدأت تتغذى برضه، خلايا، بدها تسحب
+
+351
+00:29:01,090 --> 00:29:06,180
+الجلوكوز من الـ Serum، تجيء أنت تأخذ الـ Serum، بدك
+
+352
+00:29:06,180 --> 00:29:10,720
+تفحص له السكر، بتلاقي السكر كتير واطي، بتلاقي مثلاً
+
+353
+00:29:10,720 --> 00:29:16,510
+30، 20، بتقولي طيب ليش هيك؟ هل المريض عن جد عنده
+
+354
+00:29:16,510 --> 00:29:21,310
+Hypoglycemia، انخفاض في مستوى السكر، حالة مرضية، ولا
+
+355
+00:29:21,310 --> 00:29:28,190
+المشكلة كانت إنك نسيت، الـ Serum فوق الـ RBCs، وصار في
+
+356
+00:29:28,190 --> 00:29:32,590
+احتكاك بين الـ Serum والـ RBCs، وبالتالي الخلايا عملت
+
+357
+00:29:32,590 --> 00:29:36,930
+Glycolysis، عملت Glycolysis، يعني سحبت الجلوكوز من
+
+358
+00:29:36,930 --> 00:29:41,870
+الـ Serum، عشان هيك بنقول لك أول ما تصلك العينة، على طول
+
+359
+00:29:42,030 --> 00:29:46,390
+لفّيها على الجهاز، وفصّلي الـ Serum في أنبوبة منفصلة
+
+360
+00:29:46,390 --> 00:29:52,270
+وكمان شغلة، عشان نمنع الـ Glycolysis تماماً، ضيفي الـ
+
+361
+00:29:52,270 --> 00:29:57,250
+Sodium Fluoride أثناء جمع العينة، ضيفي Sodium
+
+362
+00:29:57,250 --> 00:30:01,770
+Fluoride في أنبوبة الجمع، لأن هذه المادة تمنع خلايا
+
+363
+00:30:01,770 --> 00:30:06,850
+الـ RBCs تسحب السكر من الـ Serum، تمام؟ الـ
+
+364
+00:30:06,850 --> 00:30:13,450
+Glycolysis، يبقى مفتوحاً في غرفة حارة، ربما حوالي
+
+365
+00:30:13,450 --> 00:30:18,750
+10 مليجرام في ديسيلتر في ساعة، لو كانت خلايا الـ
+
+366
+00:30:18,750 --> 00:30:24,670
+RBCs contact مع الـ Serum، وتركتيها أنت في الأنبوبة في
+
+367
+00:30:24,670 --> 00:30:30,290
+درجة حرارة شوية مرتفعة، يعني warm room، درجات حرارة
+
+368
+00:30:30,290 --> 00:30:38,220
+حارة، وتركتيها لمدة ساعة، كل ساعة مستوى السكر بيقل
+
+369
+00:30:38,220 --> 00:30:43,640
+بنسبة 10 مليجرام per deciliter، كل ساعة السكر
+
+370
+00:30:43,640 --> 00:30:47,700
+بيقل 10 مليجرام per deciliter، طب لو تركتيها
+
+371
+00:30:47,700 --> 00:30:52,800
+ساعتين، مستوى السكر هيقل 20 مليجرام، لو تركتيها
+
+372
+00:30:52,800 --> 00:30:57,600
+الأنبوبة ثلاث ساعات، مستوى السكر هيقل 30 مليجرام
+
+373
+00:30:57,600 --> 00:31:03,200
+per deciliter، فهذا أمر خطير، The decrease in serum
+
+374
+00:31:03,200 --> 00:31:08,400
+glucose concentration is negligible، بيحكي لي يعني
+
+375
+00:31:08,400 --> 00:31:14,160
+الانخفاض في مستوى السكر يمكن تفاديه، تمام؟ أنا ممكن
+
+376
+00:31:14,160 --> 00:31:19,860
+أتفاذاه كيف؟ لو أنا جمعت الـ blood sample، if the
+
+377
+00:31:19,860 --> 00:31:24,700
+blood sample is kept cool، لو أنت جمعتي العينة في
+
+378
+00:31:24,700 --> 00:31:29,760
+درجات حرارة باردة، معظم المختبرات مكيفة، لأن معظم
+
+379
+00:31:29,760 --> 00:31:34,120
+الفحوصات بتحتاج درجات حرارة يعني لطيفة، مش تكون
+
+380
+00:31:34,120 --> 00:31:39,320
+حارة كتير أو باردة كتير، and the serum separated، و
+
+381
+00:31:39,320 --> 00:31:44,040
+تفصلي الـ serum بسرعة from the clot، تفصلي الـ serum عن
+
+382
+00:31:44,040 --> 00:31:49,860
+خلايا الـ RBCs خلال نصف ساعة من جمع العينة، يعني خلال
+
+383
+00:31:49,860 --> 00:31:54,730
+نصف ساعة من جمعتي العينة بسرعة بدك تلفّي العينة، تفصلي
+
+384
+00:31:54,730 --> 00:32:00,130
+الـ serum، وتشتغلي لها فحص السكر، عشان تتفادي نقصان
+
+385
+00:32:00,130 --> 00:32:04,750
+السكر نتيجة عملية الـ Glycolysis اللي بتصير،
+
+386
+00:32:04,750 --> 00:32:10,910
+الـ Glycolysis هو سحب خلايا الـ RBCs لمستوى السكر
+
+387
+00:32:10,910 --> 00:32:17,860
+اللي موجود في الـ serum، نتيجة احتكاكهم في بعض، There
+
+388
+00:32:17,860 --> 00:32:
+
+445
+00:37:05,280 --> 00:37:10,040
+ولو عُيدَ التجربة ثاني، برضه النتائج هتطلع مختلفة، فكلام
+
+446
+00:37:10,040 --> 00:37:13,700
+Technician أنت هتشوف فيه Variation، فيه اختلاف في
+
+447
+00:37:13,700 --> 00:37:17,980
+النتائج خلال اليوم، معنى الكلام إنه فيه problem
+
+448
+00:37:17,980 --> 00:37:21,340
+الإنسان الطبيعي ما بيكونش فيه اختلاف في نتائجه
+
+449
+00:37:21,340 --> 00:37:25,820
+مهما عُيدَ عليه الفحص، بس الإنسان اللي عنده مشاكل هيكون
+
+450
+00:37:25,820 --> 00:37:30,500
+فيه عنده variation في النتائج، وهذا الفحص اسمه
+
+451
+00:37:30,500 --> 00:37:34,200
+casual blood glucose، يا جماعة، هذا الـ Random  عمله
+
+452
+00:37:35,000 --> 00:37:39,560
+عشان مثلًا أنا خلال اليوم كنت قاعدة وباكل وبشرب
+
+453
+00:37:39,560 --> 00:37:45,740
+فجأة أغمى عليّ مثلًا، أخدوني على المستشفى، طلب الدكتور
+
+454
+00:37:45,740 --> 00:37:49,700
+فحص السكر، أقول له لا والله هي ما كانتش صائمة طول اليوم
+
+455
+00:37:49,700 --> 00:37:54,350
+بتاكل، بتشرب، عشان هيك عملوا فحص اسمه Random Blood
+
+456
+00:37:54,350 --> 00:37:59,210
+Sugar، بأي وقت بسحب عينة دم، بعمل لك فحص السكر من غير
+
+457
+00:37:59,210 --> 00:38:04,850
+أي شروط، ومن غير ما يكون الصوم إشي أساسي، طبعًا الـ
+
+458
+00:38:04,850 --> 00:38:08,710
+Random Blood Sugar له Normal Range خاص فيه، والـ
+
+459
+00:38:08,710 --> 00:38:11,650
+Fasting Blood Sugar، والـ Two Hour Post Prandial Blood Sugar
+
+460
+00:38:11,650 --> 00:38:15,310
+بدنا نفهم إن كل فحص من هذه الفحوصات لها
+
+461
+00:38:15,310 --> 00:38:21,350
+Normal Range خاص فيها، اسم طريقتنا لـ Trenders
+
+462
+00:38:21,350 --> 00:38:26,630
+Method، هذا مبدأ شغل الـ Kit تبع السكر، الـ Reagent
+
+463
+00:38:26,630 --> 00:38:31,890
+تبع السكر الجلوكوز، أخدناه في الحيوية، نوع الجلوكوز
+
+464
+00:38:31,890 --> 00:38:35,790
+الموجود في السيرم تبع الإنسان من نوع Alpha-D
+
+465
+00:38:35,790 --> 00:38:40,610
+-Glucose، هذا الجلوكوز بيكون موجود في عينة بروح
+
+466
+00:38:40,610 --> 00:38:45,290
+أضيف عليه الـ Reagent تبع السكر، الـ Reagent بيحتوي
+
+467
+00:38:45,290 --> 00:38:50,350
+على إنزايم اسمه Mutarotase، إنزايم هذا الإنزيم
+
+468
+00:38:50,350 --> 00:38:55,650
+بيحول الـ Alpha-D جلوكوز للـ Beta-D جلوكوز، هالجلوكوز الـ
+
+469
+00:38:55,650 --> 00:38:59,670
+Beta-D جلوكوز في وجود الميّه، أيضًا الميّه هي من
+
+470
+00:38:59,670 --> 00:39:04,430
+ضمن مكونات الرياجنت، وفي وجود الـ Oxygen، الـ O2
+
+471
+00:39:04,430 --> 00:39:09,560
+اللي جاي من الهواء الجوي، وفي وجود إنزايم الجلوكوز
+
+472
+00:39:09,560 --> 00:39:14,800
+أكسيداز اللي بشكل أساسي موجود في الـ Reagent، هيحول
+
+473
+00:39:14,800 --> 00:39:20,540
+الـ Beta-D-Glucose إلى الـ D-Gluconic Acid و H2O2
+
+474
+00:39:20,540 --> 00:39:26,960
+هالجلوكوز الـ H2O2 في وجود مادة الـ 4-Aminophenazone
+
+475
+00:39:26,960 --> 00:39:31,440
+والفينول، برضه هذه كلها من ضمن مكونات الـ Reagent
+
+476
+00:39:31,440 --> 00:39:35,320
+وفي وجود إنزايم البروكسيداز برضه من مكونات
+
+477
+00:39:35,320 --> 00:39:38,870
+الـ Reagent، في الآخر هنحصل على مادة اسمها
+
+478
+00:39:38,870 --> 00:39:45,010
+Quinoneimine و 4 جزيئات ميّه، هذه المادة
+
+479
+00:39:45,010 --> 00:39:50,470
+Quinoneimine هذه هي الـ colored compound، هذا هو
+
+480
+00:39:50,470 --> 00:39:57,150
+المركب الملون الناتج من تفاعل الـ reaction تبع
+
+481
+00:39:57,150 --> 00:40:02,650
+السكر مع السيرم، ومع السكر الموجود في السيرم تبع
+
+482
+00:40:02,650 --> 00:40:09,500
+المريض، يعني حاصل تفاعل الـ Reagent مع السكر
+
+483
+00:40:09,500 --> 00:40:13,600
+الجلوكوز اللي موجود في السيرم تبع المريض، قلنا في
+
+484
+00:40:13,600 --> 00:40:18,060
+الآخر بيطلع عندي مركب له لون، The intensity of the
+
+485
+00:40:18,060 --> 00:40:22,980
+color formed، شدة اللون تبع هذا المركب اللي اتكون
+
+486
+00:40:22,980 --> 00:40:26,480
+is proportional to the glucose concentration in
+
+487
+00:40:26,480 --> 00:40:31,040
+the sample، بتتناسب تناسب طردي مع تركيز السكر في
+
+488
+00:40:31,040 --> 00:40:35,940
+العينة، يعني لو كان الشخص سكر 200 و 300، نتيجة
+
+489
+00:40:35,940 --> 00:40:41,360
+تفاعل السكر مع الـ Reagent هيظهر لون، الـ intensity
+
+490
+00:40:41,360 --> 00:40:48,550
+الشدة تبعته هيكون كتير غامق، تمام؟ وهذا اللون
+
+491
+00:40:48,550 --> 00:40:52,370
+بتنقياسه على جهاز الـ Spectrophotometer، على
+
+492
+00:40:52,370 --> 00:40:58,170
+wavelength من 500 لـ 550 نانومتر، أنت فيك تضبطيه
+
+493
+00:40:58,170 --> 00:41:03,210
+على أي wavelength بتراوح ما بين الـ 500 و 550
+
+494
+00:41:03,210 --> 00:41:08,100
+نانومتر، نيجي لها الـ procedure طبعًا إن شاء الله
+
+495
+00:41:08,100 --> 00:41:12,960
+هنشتغلها عمليًّا لما نرجع على الجامعة، الـ procedure
+
+496
+00:41:12,960 --> 00:41:18,540
+كالتالي: أول شيء بتروح تجيب rack وبتحط عليه أربع
+
+497
+00:41:18,540 --> 00:41:23,880
+plastic tubes، تمام؟ وبتعملي Labeling على الـ
+
+498
+00:41:23,880 --> 00:41:27,420
+plastic tubes، واحدة بتكتبي عليها Blank، واحدة بتكتبي
+
+499
+00:41:27,420 --> 00:41:32,340
+عليها Standard، واحدة بتكتبي عليها Control، والأنبوبة
+
+500
+00:41:32,340 --> 00:41:35,920
+الرابعة بتكتبي عليها الـ Patient Sample، عينة
+
+501
+00:41:35,920 --> 00:41:41,360
+المريض، تمام؟ الأربع أنابيب كلهم بنضيف على كل
+
+502
+00:41:41,360 --> 00:41:48,620
+أنبوبة 1 ML من Reagent A، اللي هو الـ Reagent الخاص
+
+503
+00:41:48,620 --> 00:41:54,000
+بالسكر، تمام؟ بتجيبي أربع قنابيب بتعملي لهم Labeling
+
+504
+00:41:54,000 --> 00:41:58,940
+تكتبي Blank، و Standard، و Control، و Sample، والأربع
+
+505
+00:41:58,940 --> 00:42:04,400
+قنابيب هدول كل أنبوبة بتحطي عليها 1 ML يعني ألف
+
+506
+00:42:04,400 --> 00:42:10,580
+مايكرو ليتر من الـ Reagent تبع السكر، تمام؟ بعدين
+
+507
+00:42:10,580 --> 00:42:15,920
+في كيت السكر جواها أنبوبة كتير صغيرة اسمها Standard
+
+508
+00:42:15,920 --> 00:42:21,560
+هذا الـ Standard عبارة عن محلول جواته سكر، عبارة عن
+
+509
+00:42:21,560 --> 00:42:26,920
+solution بيحتوي على السكر، تمام؟ إله تركيز معين
+
+510
+00:42:26,920 --> 00:42:31,800
+بيكون، بتروحي تجيبي هذه أنبوبة الـ Standard الصغيرة
+
+511
+00:42:31,800 --> 00:42:37,380
+الموجودة في الـ Kit، تاخدي منها عشرة مايكرو ليتر و
+
+512
+00:42:37,380 --> 00:42:42,900
+بتحطيها في الـ plastic tube تبعت الـ Standard و
+
+513
+00:42:42,900 --> 00:42:47,060
+بتعملي mix، إذًا الـ tube تبعت الـ Standard أصبح فيها
+
+514
+00:42:47,060 --> 00:42:52,560
+1 ML من الـ Reagent و عشرة مايكرو ليتر من الـ
+
+515
+00:42:52,560 --> 00:42:58,110
+Standard نفسه و بتعملي mix منيح، تمام؟ بعدين بتروحي
+
+516
+00:42:58,110 --> 00:43:02,150
+تجيبي أنبوبة الـ Control، هذا بيكون جاي من الشركة
+
+517
+00:43:02,150 --> 00:43:06,910
+powder وبنحله في ميّه، وبتروحي تاخدي من أنبوبة الـ
+
+518
+00:43:06,910 --> 00:43:13,600
+Control عشرة مايكرو ليتر، تمام؟ وبتحطيها في الأنبوبة
+
+519
+00:43:13,600 --> 00:43:16,860
+تبعت الـ Control،  plastic tube تبعت الـ Control
+
+520
+00:43:16,860 --> 00:43:24,100
+هيك tube الـ Control بيكون فيها 1 ML Reagent و 10
+
+521
+00:43:24,100 --> 00:43:30,500
+مايكروليتر من الـ Control نفسه، تمام؟ بعدين بتروحي
+
+522
+00:43:30,500 --> 00:43:34,540
+تجيب الـ patient sample، عينة المريض، الـ serum تبعه
+
+523
+00:43:34,540 --> 00:43:38,780
+أو الـ plasma تبعته اللي بدك تفحصي لها السكر، تاخدي
+
+524
+00:43:38,780 --> 00:43:42,880
+منها عشرة microliter و بتحطيها في أنبوبة الـ
+
+525
+00:43:42,880 --> 00:43:50,370
+patient sample، أصبح فيها 1 ML Reagent و 10 µL من الـ
+
+526
+00:43:50,370 --> 00:43:56,730
+serum تبع الـ Patient، برضه بتروحي تجيبي 10 µL من الـ
+
+527
+00:43:56,730 --> 00:44:00,250
+distilled water من الميّ المعقّمة، و بتحطيها في
+
+528
+00:44:00,250 --> 00:44:05,830
+أنبوبة Blank، إذًا أنبوبة Blank فيها 1 ML Reagent
+
+529
+00:44:05,830 --> 00:44:11,410
+مع 10 µL distilled water، هيك الأربع أنابيب أنا حضرتهم
+
+530
+00:44:11,410 --> 00:44:15,370
+فيه بنات هيسألوني، الـ Control ليش أنا أمشيها؟ يعني
+
+531
+00:44:15,370 --> 00:44:19,870
+مش هيفيدني في الحسابات، وفي إني أطلع تركيز السكر
+
+532
+00:44:19,870 --> 00:44:24,390
+عند المريض، okay؟ صح كلامكم، بس إحنا اتفقنا، في
+
+533
+00:44:24,390 --> 00:44:30,470
+كل شغل، في كل فحص، لازم أمشي Control، سواء أمشي
+
+534
+00:44:30,470 --> 00:44:33,330
+الـ Normal والـ Abnormal Control، أو أمشي نوع
+
+535
+00:44:33,330 --> 00:44:39,170
+واحد، تمام؟ هي كل أنبوبة صار فيها 1 ML reagent
+
+536
+00:44:39,870 --> 00:44:44,910
+وفيها الـ 10 µL، اللي منها مثلًا الـ Blank، 1 ML
+
+537
+00:44:44,910 --> 00:44:50,050
+reagent و 10 µL ميّه، الـ Standard، 1 ML reagent
+
+538
+00:44:50,050 --> 00:44:53,630
+و 10 µL الـ Standard، الـ Control، 1 ML
+
+539
+00:44:53,630 --> 00:44:57,590
+reagent و 10 µL Control، الـ Sample، 1 ML
+
+540
+00:44:57,590 --> 00:45:02,050
+reagent و 10 µL Sample، تاخدي الأربع قنابيب
+
+541
+00:45:03,040 --> 00:45:07,600
+وبتحطيهم في الـ Water Bath على درجة حرارة 37 لمدة
+
+542
+00:45:07,600 --> 00:45:12,600
+10 دقائق، وبعد ما تخلص الـ 10 دقائق تاخدي هذه
+
+543
+00:45:12,600 --> 00:45:17,850
+الأنابيب، بتضبطي جهاز الـ Spectrophotometer العادي
+
+544
+00:45:17,850 --> 00:45:21,590
+طبعًا أنتم فحص السكر اشتغلتوه على فكرة في السوائل
+
+545
+00:45:21,590 --> 00:45:27,590
+وبتضبطي الجهاز على 505 نانومتر،  كتب لك من 530 لـ 590
+
+546
+00:45:27,590 --> 00:45:32,490
+برضه صح، بتضبطيه على أي wavelength، تمام؟ وبعد هيك
+
+547
+00:45:32,490 --> 00:45:36,710
+بتحطي، بتجيبي أنبوبة الـ Blank بتحطيها في الـ cuvette
+
+548
+00:45:36,710 --> 00:45:41,470
+وبتصفري الجهاز عليها، بعد هيك بتحطي الـ Standard
+
+549
+00:45:41,470 --> 00:45:45,820
+وبتاخدي absorbance، وبتحطي الـ Control وبتاخدي الـ
+
+550
+00:45:45,820 --> 00:45:50,040
+Absorbance تبعته، وبتحطي الـ Sample و بتاخدي الـ
+
+551
+00:45:50,040 --> 00:45:55,250
+Absorbance تبعته، آخر جملة بيحكيلك الـ Color is
+
+552
+00:45:55,250 --> 00:46:00,870
+stable for 60 minutes، يعني الفحص بيضل stable 60
+
+553
+00:46:00,870 --> 00:46:04,630
+دقيقة، ساعة كاملة، يعني لو أنا طلعت الأنابيب من الـ
+
+554
+00:46:04,630 --> 00:46:08,150
+water bath وما كانش عندي وقت أروح أقرأهم على
+
+555
+00:46:08,150 --> 00:46:12,330
+الجهاز تبع الـ Spectro بسرعة، ممكن أتركهم لمدة
+
+556
+00:46:12,330 --> 00:46:18,460
+ساعة، الفحص بيضل تمام وبيطلع نتائجه، نيجي أنا
+
+557
+00:46:18,460 --> 00:46:24,140
+طلعت الـ Absorbance تبع الـ Sample من الجهاز، وطلعت
+
+558
+00:46:24,140 --> 00:46:29,620
+الـ Absorbance تبع الـ Standard من الجهاز، تمام؟
+
+559
+00:46:29,620 --> 00:46:35,490
+نيجي أنا إيش بدي أحسب؟ نشوف قانون بير لامبرت، الـ
+
+560
+00:46:35,490 --> 00:46:40,730
+Glucose Concentration، تركيز السكر تبع الـ patient
+
+561
+00:46:40,730 --> 00:46:45,330
+sample بالـ mg/dL، إيش بيساوي؟
+
+562
+00:46:45,330 --> 00:46:51,230
+بالطبق القانون، الـ Absorbance تبع الـ Sample على الـ
+
+563
+00:46:51,230 --> 00:46:56,830
+Absorbance تبع الـ Standard ضرب الـ Concentration للـ
+
+564
+00:46:56,830 --> 00:47:00,570
+Standard، الـ Absorbance للـ Sample أنا جيبته من
+
+565
+00:47:00,570 --> 00:47:04,400
+الجهاز، والـ Absorbance للـ Standard جيبته من الجهاز
+
+566
+00:47:04,400 --> 00:47:09,180
+الـ Standard Concentration، كنا اتفقنا إن أنبوبة
+
+567
+00:47:09,180 --> 00:47:14,720
+الـ Standard عبارة عن سكر، وهذا السكر له تركيز معين
+
+568
+00:47:14,720 --> 00:47:19,020
+كيف بدي أعرف تركيزه؟ على الأنبوبة نفسها بيكون
+
+569
+00:47:19,020 --> 00:47:23,820
+مكتوب تركيزه، وحطلعوا أنتم لحالكم الـ Standard
+
+570
+00:47:23,820 --> 00:47:28,510
+Concentration، أول ما تتطلعي عليه علبة الـ Standard،
+
+571
+00:47:28,510 --> 00:47:32,910
+هعطيك إياها، بيكون مكتوب عليها تركيز السكر اللي
+
+572
+00:47:32,910 --> 00:47:35,990
+موجود في هذا الـ Standard، وبالتالي الـ Standard
+
+573
+00:47:35,990 --> 00:47:40,610
+Concentration معلوم، من وين معلوم؟ على الأنبوبة
+
+574
+00:47:40,610 --> 00:47:44,270
+تبعت الـ Standard، إذًا الثلاث مجاهيل الموجودين،
+
+575
+00:47:44,270 --> 00:47:52,630
+بينطبق عليهم وبينطلع النتيجة تبعت السكر في الـ
+
+576
+00:47:52,630 --> 00:47:57,380
+Patient Sample، تمام؟ الوحدة اللي إحنا بنستخدمها هي
+
+577
+00:47:57,380 --> 00:48:01,720
+mg/dL، هذه الشائعة، لكن ممكن أطلع
+
+578
+00:48:01,720 --> 00:48:06,060
+مستوى السكر بوحدة، بوحدة أخرى اسمها الـ mmol
+
+579
+00:48:06,060 --> 00:48:10,620
+/L، نشوف كيف بدنا نعمل الـ conversion factor
+
+580
+00:48:10,620 --> 00:48:15,040
+التحويل، نيجي النتيجة اللي طلعت معك بالـ mg
+
+581
+00:48:15,040 --> 00:48:20,000
+/dL، النتيجة بتروحي تضربيها بهذا الرقم 0.05555
+
+582
+00:48:20,000 --> 00:48:26,400
+فتطلع النتيجة بالـ mmol/L، تمام؟
+
+583
+00:48:26,400 --> 00:48:32,440
+لكن لو أنا عندي مستوى السكر بوحدة الملي مول per لتر
+
+584
+00:48:32,440 --> 00:48:37,400
+وبدي أحوله لملي جرام per دي سي لتر، تضربي هاد
+
+585
+00:48:37,400 --> 00:48:41,420
+النتيجة تبع الملي مول per لتر، بتضربيها بـ 18
+
+586
+00:48:41,420 --> 00:48:47,440
+برضه لو عندي أنا مستوى السكر بالـ mg/dL
+
+587
+00:48:47,440 --> 00:48:51,820
+وبدي أطلعه بالـ mmol/L، ممكن أقسم
+
+588
+00:48:51,820 --> 00:48:57,100
+على 18، التحويلات لو حفظتي واحدة تحفظي الباقي،
+
+589
+00:48:57,100 --> 00:49:01,550
+سهلة كتير، تطبيق قانون Beer's Law برضه سهل
+
+590
+00:49:01,550 --> 00:49:05,030
+Absorbance الـ Sample والـ Standard معلوم، وتركيز
+
+591
+00:49:05,030 --> 00:49:10,490
+الـ Standard برضه معلوم، بيجي مع الشركة، من الشركة جاهز
+
+592
+00:49:10,490 --> 00:49:16,910
+وبالتالي بنقدر نحسب مستوى السكر للمريض في عينته، هنا
+
+593
+00:49:16,910 --> 00:49:23,090
+الـ Normal Range، الوضع الطبيعي، هذا حفظ لما نيجي
+
+594
+00:49:23,090 --> 00:49:27,690
+نتحدث عن الفحص الأول، أخدناه الـ fasting blood sugar
+
+595
+00:49:27,690 --> 00:49:33,730
+الإنسان الطبيعي من 70 لـ 110، هذا Normal Fasting
+
+596
+00:49:33,730 --> 00:49:40,110
+Glucose، طب لو إنسان ثاني طلع عنده من 110 لـ 126
+
+597
+00:49:40,110 --> 00:49:44,190
+mg/dL، هذا بحكي عنه Prediabetic
+
+598
+00:49:44,190 --> 00:49:49,430
+يعني مشكوك في أمره، يعني عنده risk factor واحتمال في
+
+599
+00:49:49,430 --> 00:49:54,330
+المستقبل، احتمال كبير يصير عنده سكر، طب لو شخص ثالث
+
+600
+00:49:54,330 --> 00:50:01,490
+عمل فحص وطلع سكره 126 فما فوق، معنى الكلام
+
+601
+00:50:01,490 --> 00:50:09,070
+هذا أكيد بيكون diabetic، تمام؟ أما الـ 2 Hour Post
+
+602
+00:50:09,070 --> 00:50:14,490
+Prandial Blood Sugar اللي بنعمله لمرضى السكري، الناس
+
+603
+00:50:14,490 --> 00:50:18,930
+اللي بياخدوا الإنسولين، عندهم بتكون normal وطبيعية
+
+604
+00:50:18,930 --> 00:50:25,770
+و كويسة، لازم يطلع سكرهم من 110 لـ 140 mg/dL
+
+605
+00:50:25,770 --> 00:50:29,450
+الـ Random blood sugar، يعني لو أنت أكلت
+
+606
+00:50:29,450 --> 00:50:34,830
+وشربت وتغديت وسُحبت منك عينة، يفترض سكرِك يطلع شكل
+
+607
+00:50:34,830 --> 00:50:41,070
+طبيعي، أقل من 140 mg/dL، إذًا هذا
+
+608
+00:50:41,070 --> 00:50:48,240
+الـ Normal Range للثلاث فحوصات، In diabetes mellitus
+
+609
+00:50:48,240 --> 00:50:52,880
+عند مرضى السكري، the level of fasting blood
+
+610
+00:50:52,880 --> 00:50:58,480
+glucose is 126 mg/dL، يعني لو شخص
+
+611
+00:50:58,480 --> 00:51:03,320
+عملت له fasting blood sugar، الفحص الأول، وطلع عنده
+
+612
+00:
\ No newline at end of file
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/1y7q3of1Qew_raw.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/1y7q3of1Qew_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..f1c66824c34a67486e41f85ef1c4fa2e1fa3c578
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/1y7q3of1Qew_raw.srt
@@ -0,0 +1,2648 @@
+1
+00:00:00,540 --> 00:00:03,940
+السلام عليكم ورحمة الله وبركاته يعطيكم العافية
+
+2
+00:00:03,940 --> 00:00:08,480
+جميعا إن شاء الله اليوم محاضرتنا بعنوان Hemoglobin
+
+3
+00:00:08,480 --> 00:00:13,120
+A1c أو ما يسمى polyglycated hemoglobin أو
+
+4
+00:00:13,120 --> 00:00:17,300
+polyglycosylated hemoglobin اللي هو فحص مخزون
+
+5
+00:00:17,300 --> 00:00:23,260
+السكرهنحكي عن الـ Introduction «Diabetes mellitus
+
+6
+00:00:23,260 --> 00:00:26,000
+as previously stated is a condition of
+
+7
+00:00:26,000 --> 00:00:30,680
+hyperglycemia» كلنا عارفين أن مرض السكري ومرضاء
+
+8
+00:00:30,680 --> 00:00:35,480
+السكري يعانوا من الـ hyperglycemia، ارتفاع مستوى
+
+9
+00:00:35,480 --> 00:00:39,910
+السكر في الدمIt is estimated that this condition
+
+10
+00:00:39,910 --> 00:00:44,530
+affects 2.5 لـ 5% of the population and is
+
+11
+00:00:44,530 --> 00:00:48,310
+considered to be the fifth leading cause of death
+
+12
+00:00:48,310 --> 00:00:53,950
+in the United States بيحكيلي إن مرض السكري أثر على
+
+13
+00:00:53,950 --> 00:01:00,890
+2.5 ل 5%من ال population يعني أثر على حياة ناس
+
+14
+00:01:00,890 --> 00:01:08,290
+كتيرة في العالم ويعتبر مرض السكري هو خامس سبب يؤدي
+
+15
+00:01:08,290 --> 00:01:13,210
+إلى الوافقة في ال United Statesفي الولايات المتحدة
+
+16
+00:01:13,210 --> 00:01:18,730
+الأمريكية صنفوا إنه مرض السكري هو خام السبب يؤدي
+
+17
+00:01:18,730 --> 00:01:24,150
+للوفا، تمام؟ The disease is associated with a
+
+18
+00:01:24,150 --> 00:01:27,870
+number of serious micro- and macrovascular
+
+19
+00:01:27,870 --> 00:01:32,470
+complications involving the eyes, kidneys, heart
+
+20
+00:01:32,470 --> 00:01:37,780
+and blood vesselsوربما بشكل كبير تحرر قيمة الحياة
+
+21
+00:01:37,780 --> 00:01:44,950
+أو تحرر عمر الحياة للشخص اللذي كان محطمبحكيلي إنه
+
+22
+00:01:44,950 --> 00:01:50,730
+مرض السكري المشكلة مش في المرض يعني المرض يعني مع
+
+23
+00:01:50,730 --> 00:01:54,690
+الوقت الإنسان بتعامل معاه بياخد إبر إنسولين
+
+24
+00:01:54,690 --> 00:01:59,130
+بتنطنظيمه المشكلة في الأشخاص اللي ما بيحافظوا على
+
+25
+00:01:59,130 --> 00:02:03,570
+سكرهم على المدى اللي بعيد مريض السكري بيصير عنده
+
+26
+00:02:03,570 --> 00:02:07,850
+complications بيصير عنده مضاعفات المضاعفات هذه
+
+27
+00:02:07,850 --> 00:02:12,700
+نوعينيحدث عنده microvascular complication أو
+
+28
+00:02:12,700 --> 00:02:17,920
+macrovascular complication لما أحكي microvascular
+
+29
+00:02:17,920 --> 00:02:23,780
+complication هذه المضاعفات تشمل ثلاث شغلات ممكن
+
+30
+00:02:23,780 --> 00:02:29,060
+يصير عنده الـ neuropathy مشاكل في الأعصاب في
+
+31
+00:02:29,060 --> 00:02:33,880
+النيورونأو Nephropathy، مشاكل في النفرون، أي في
+
+32
+00:02:33,880 --> 00:02:39,000
+الكدني أو ممكن يصير عنده Retinopathy، مشاكل في
+
+33
+00:02:39,000 --> 00:02:43,680
+القرنية تبع العين إذاً الـMicrovascular
+
+34
+00:02:43,680 --> 00:02:48,220
+Complication إما بيصير عنده مشكلة في الأعصاب أو في
+
+35
+00:02:48,220 --> 00:02:53,650
+الكلا أو في العينأما الـMacrovascular Complication
+
+36
+00:02:53,650 --> 00:02:58,410
+هذه مضاعفات كبيرة شوية بيصير عندهم على المدى
+
+37
+00:02:58,410 --> 00:03:02,770
+البعيد مشكلة في الـheart and blood vessel مشكلة في
+
+38
+00:03:02,770 --> 00:03:07,510
+القلب والأوعية الدموية كل هذه الـComplication
+
+39
+00:03:07,510 --> 00:03:13,190
+المضاعفات بتقصر من عمر الإنسان وتسرع في إحداث
+
+40
+00:03:13,190 --> 00:03:18,350
+الوفاةبنكمل بالـ Introduction «There is a
+
+41
+00:03:18,350 --> 00:03:21,270
+relationship between control of the glucose
+
+42
+00:03:21,270 --> 00:03:25,630
+concentration fluctuation and the progression of
+
+43
+00:03:25,630 --> 00:03:30,610
+the disease complication» هناك علاقة ما بين تنظيم
+
+44
+00:03:30,610 --> 00:03:35,930
+مستوى السكر في الدم وما بين حدوث الـ complication
+
+45
+00:03:35,930 --> 00:03:41,470
+على المدى البعيد يعني مثلا شخص مريض سكري، تمام؟هذا
+
+46
+00:03:41,470 --> 00:03:46,010
+مريض السكري لو حافظ على نفسه اتبع حمية غزائية
+
+47
+00:03:46,010 --> 00:03:50,710
+كويسة أخد الإنسولين بالموعد المناسب معنى الكلام
+
+48
+00:03:50,710 --> 00:03:56,830
+احتمال وصوله لـ الـ Complication لمرحلة المضاعفات
+
+49
+00:03:56,830 --> 00:04:02,130
+هتكون نادر ما يصير عنده مضاعفاتأما شخص تاني مريض
+
+50
+00:04:02,130 --> 00:04:07,150
+سكري ما بيعمل control عن نفسه يعني ما بيحافظ عن
+
+51
+00:04:07,150 --> 00:04:11,010
+نفسه و بيخبس كتير في الأكل و ما بياخد جرعات
+
+52
+00:04:11,010 --> 00:04:15,770
+الانسولين وبالتالي مستوى السكر دايما بيكون عنده
+
+53
+00:04:15,770 --> 00:04:20,090
+عالي كتير في الدم و مافيه تنظيم هذا الشخص احتمال
+
+54
+00:04:20,090 --> 00:04:25,750
+وصوله لـComplication للمضاعفات هيكون سريع سريع
+
+55
+00:04:25,750 --> 00:04:30,050
+هيصير عنده مضاعفات و بعد هيك هيؤدي ذلك إلى الوفاة
+
+56
+00:04:30,390 --> 00:04:36,430
+إذاً هناك علاقة ما بين المحافظة على مستوى السكر في
+
+57
+00:04:36,430 --> 00:04:42,770
+الدم وما بين الوصول لـComplicationThere should be
+
+58
+00:04:42,770 --> 00:04:46,870
+a method to quantify accurately and objectively
+
+59
+00:04:46,870 --> 00:04:51,190
+the degree of altered blood glucose control over a
+
+60
+00:04:51,190 --> 00:04:56,250
+long period of time عشان هيك لابد من إيجاد طريقة،
+
+61
+00:04:56,250 --> 00:05:01,350
+من إيجاد فحص، هذا الفحص يعني أنا أعمله باستمرار
+
+62
+00:05:01,350 --> 00:05:06,850
+لمرضى السكري هو فحص الـ Hemoglobin A1C مخزون السكر
+
+63
+00:05:06,850 --> 00:05:12,370
+عادة بنعمل كل 3 شهوركل 3 شهور بنحكي لمريض السكري
+
+64
+00:05:12,370 --> 00:05:18,070
+روح العيادة و اعمل مخزون السكر عشان نشوف كيف هذا
+
+65
+00:05:18,070 --> 00:05:26,090
+الفحص بيحكيلي كيف كان السكر عند هذا المريضقبل 3
+
+66
+00:05:26,090 --> 00:05:31,790
+شهور سابقة يعني قبل 3 شهور كيف كان وضع السكر عند
+
+67
+00:05:31,790 --> 00:05:36,390
+هذا المريض إذا أنا من خلال هذا الفحص بدي أعمل
+
+68
+00:05:36,390 --> 00:05:41,190
+مراقبة لمريض السكر بدي أشوفه قبل 3 شهور كيف كان
+
+69
+00:05:41,190 --> 00:05:46,190
+وضعه كان بياكل ولا حاجة بنفسه؟ كان بالتزم بجرعات
+
+70
+00:05:46,190 --> 00:05:48,790
+الإنسلين ولا لأ؟ تمام؟
+
+71
+00:05:51,590 --> 00:05:55,730
+الـGlycosylated Hemoglobin أو ما يسمى بالـGlycated
+
+72
+00:05:55,730 --> 00:06:00,950
+Hemoglobin أو Hemoglobin A1C يعني مخزون السكر هذه
+
+73
+00:06:00,950 --> 00:06:07,090
+كلها مسمية لفحص مخزون السكر in adults Hemoglobin
+
+74
+00:06:07,090 --> 00:06:10,540
+is a mixture of three formsHemoglobin A1،
+
+75
+00:06:10,540 --> 00:06:14,320
+Hemoglobin A2، Hemoglobin F With Hemoglobin A1
+
+76
+00:06:14,320 --> 00:06:17,900
+Predominating أخدته في الـHemotology إن
+
+77
+00:06:17,900 --> 00:06:22,920
+الـHemoglobins الأساسية اللي موجودة جواد خلايا
+
+78
+00:06:22,920 --> 00:06:29,140
+الدم الحمرة هما تلاتة Hemoglobin A أو ما يسمى اسم
+
+79
+00:06:29,140 --> 00:06:33,200
+آخر له Hemoglobin A1 بدل ما يحكوا A لحالها بيحكوا
+
+80
+00:06:33,200 --> 00:06:38,860
+A1 Hemoglobin A1، Hemoglobin A2، Hemoglobin F
+
+81
+00:06:40,010 --> 00:06:45,010
+وحكينالكوا برضه إن Hemoglobin A أو ما يسمى بـ
+
+82
+00:06:45,010 --> 00:06:51,150
+Hemoglobin A1 موجود بأعلى تركيز جوات الـ RBCs هو
+
+83
+00:06:51,150 --> 00:06:57,870
+الغالب الـ Predominating هو اللي موجود بنسبة أكتر
+
+84
+00:06:57,870 --> 00:07:04,420
+من Hemoglobin A2 و Hemoglobin Fهلجيت Hemoglobin A1
+
+85
+00:07:04,420 --> 00:07:10,180
+اللي هو Hemoglobin A Consists of three sub forms
+
+86
+00:07:10,180 --> 00:07:16,920
+برضه جوات الـ RBCs عندي أنواع ثلاثة من Hemoglobin
+
+87
+00:07:16,920 --> 00:07:24,120
+A1 إيش هما Hemoglobin A1A Hemoglobin A1B and
+
+88
+00:07:24,120 --> 00:07:29,650
+Hemoglobin A1Cإذاً هذا الـ Hemoglobin اللي موجود
+
+89
+00:07:29,650 --> 00:07:34,410
+بنسبة عالية في الـ RBCs اللي هو Hemoglobin A1 في
+
+90
+00:07:34,410 --> 00:07:39,510
+منه subform في منه أيضًا أنواع مختلفة في منه
+
+91
+00:07:39,510 --> 00:07:45,950
+Hemoglobin A1C و Hemoglobin A1B و Hemoglobin A1A
+
+92
+00:07:45,950 --> 00:07:52,230
+تمام؟وحكيلكوا هنا إن هيموجلوبين A1C هذا الـ
+
+93
+00:07:52,230 --> 00:07:57,590
+Predominating هو اللي موجود أيضًا بأعلى نسبة جوات
+
+94
+00:07:57,590 --> 00:08:04,370
+الـ RBCs The term glycated hemoglobin describes a
+
+95
+00:08:04,370 --> 00:08:09,530
+chemically stable conjugate of any of forms of
+
+96
+00:08:09,530 --> 00:08:14,860
+hemoglobin with glucoseلما أحكيلكوا إيش يعني
+
+97
+00:08:14,860 --> 00:08:19,520
+Iglycated Hemoglobin أو Iglycosylated Hemoglobin
+
+98
+00:08:19,520 --> 00:08:25,500
+معناه الـ Hemoglobin مرتبط بالجلوكوز بكل بساطة
+
+99
+00:08:25,500 --> 00:08:31,080
+Iglycated Hemoglobin معناه إنه الـ Hemoglobin جوات
+
+100
+00:08:31,080 --> 00:08:39,950
+الـ RBCs مرتبط بالسكر، بالجلوكوز، تمام؟مظلومات
+
+101
+00:08:39,950 --> 00:08:45,130
+الهيموغلوبين مظلومات بطيئة بدون انزيماتيكية
+
+102
+00:08:45,130 --> 00:08:52,790
+ومستحيلة في حركة مرتبطة بالكونسنتراتشن الجلوكوز في
+
+103
+00:08:52,790 --> 00:08:59,570
+الدمالفكرة بتصير إن خلايا الـ RBCs جواها الـ
+
+104
+00:08:59,570 --> 00:09:05,550
+Subform الـ Hemoglobin أشكال Hemoglobin A1 في منه
+
+105
+00:09:05,550 --> 00:09:13,150
+أنواع A1A، A1B، A1C هذه الأنواع كيف بتتكون أصلا؟
+
+106
+00:09:13,150 --> 00:09:20,330
+اللي بيصير إن الـ RBCs جواها Hemoglobin A1 و A2 و
+
+107
+00:09:20,330 --> 00:09:26,860
+Hemoglobin Fبدخل سكر جزيئات من السكر بتكون موجودة
+
+108
+00:09:26,860 --> 00:09:31,400
+في الدم بتروح وهي فايتة جواد خلايا الدم الحمراء
+
+109
+00:09:31,400 --> 00:09:39,400
+جواد الـ RBCs وجوا الـ RBCs بيصير عندنا عملية اللي
+
+110
+00:09:39,400 --> 00:09:45,620
+هي ربط السكر بـ Hemoglobin A1 اللي هو اللي موجود
+
+111
+00:09:45,620 --> 00:09:54,920
+بأعلى نسبةونتيجة ربط السكر بـ Hemoglobin A1 بتكون
+
+112
+00:09:54,920 --> 00:10:00,200
+عندي الـ Subform التلاتة اللي حكينالكم عنهم الـ
+
+113
+00:10:00,200 --> 00:10:04,940
+Hemoglobin A1a، الـ Hemoglobin A1b، الـ Hemoglobin
+
+114
+00:10:04,940 --> 00:10:12,720
+A1c هدولة جايين من دخول السكر لخلايا الـ R-species
+
+115
+00:10:12,720 --> 00:10:22,740
+وارتباطهاB الـ Hemoglobin A1 تمام؟وهذه العملية ربط
+
+116
+00:10:22,740 --> 00:10:29,920
+السكر بهيموجلوبين A1 وتكوين الـ subform عملية تحدث
+
+117
+00:10:29,920 --> 00:10:35,480
+بشكل بطيء slowly و non enzymatic بتسير بشكل طبيعي
+
+118
+00:10:35,480 --> 00:10:41,200
+في الجسم ما بدها أي إنزيمات وبشكل irreversible
+
+119
+00:10:41,200 --> 00:10:45,220
+يعني لما يدخل السكر جوات ال RBCs هذه عملية طبيعية
+
+120
+00:10:45,220 --> 00:10:50,310
+بتسير في الجسملما يدخل السكر جوا الـ RBCs ويربط
+
+121
+00:10:50,310 --> 00:10:56,350
+بيهمoglobin A1 عشان يعطيني الـ subform التلاتة
+
+122
+00:10:56,350 --> 00:11:03,430
+A1A، A1B، A1Cهذه الـ Hemoglobins الـ Subform لما
+
+123
+00:11:03,430 --> 00:11:08,430
+بتتكون بتصير Irreversible Compound يعني مركبات
+
+124
+00:11:08,430 --> 00:11:12,570
+مابتفكش مستحيل بعد هيك السكر ينفك عن الـ
+
+125
+00:11:12,570 --> 00:11:18,050
+Hemoglobin خلاص بيضل السكر رابط بـ Hemoglobin A1
+
+126
+00:11:18,050 --> 00:11:24,870
+ومعطيني Subform مختلفة تمام؟ آخر جملة في جثة
+
+127
+00:11:24,870 --> 00:11:31,410
+العلاقة هذه هناخدها لقدامه ونفهمهاهل جيت حكينالكم
+
+128
+00:11:31,410 --> 00:11:36,550
+إنه هذه عملية طبيعية إنه جزيئات من السكر فيه الدم
+
+129
+00:11:36,550 --> 00:11:42,110
+بشكل طبيعي بتفوت جوات خلايا الـ Red Blood Cells
+
+130
+00:11:42,110 --> 00:11:49,210
+الـ RBCs وبتروح وهي رابطة بـ Hemoglobin A1 ومعتينة
+
+131
+00:11:49,320 --> 00:11:54,680
+الـ Subform Hemoglobin A1A Hemoglobin A1B و
+
+132
+00:11:54,680 --> 00:11:59,760
+Hemoglobin A1C طب هدولة الـ Subform التلاتة بإيش
+
+133
+00:11:59,760 --> 00:12:05,680
+بيختلفوا عن بعض؟ بيختلفوا بأن هذا السكر لما إجا
+
+134
+00:12:05,680 --> 00:12:10,700
+ربط، ربط سوري بالـ Hemoglobin على أي موقع ربط في
+
+135
+00:12:10,700 --> 00:12:14,640
+الـ Hemoglobin ربط في Beta Chain ولا في Alpha
+
+136
+00:12:14,640 --> 00:12:19,150
+Chain؟في أي أمينو أسد ربط ماحنا عارفين إن الـ
+
+137
+00:12:19,150 --> 00:12:23,650
+Hemoglobin عبارة عن البروتين و البروتين عبارة عن
+
+138
+00:12:23,650 --> 00:12:29,050
+مجموعة من الأحماض الأمينية فلما ييجي السكر يربط في
+
+139
+00:12:29,050 --> 00:12:35,150
+الـ Hemoglobin تمام، وين السكر بالظبط ربط؟ ربط في
+
+140
+00:12:35,150 --> 00:12:39,720
+أي أمينو أسد مع الـ Hemoglobinربط في أي تشين في
+
+141
+00:12:39,720 --> 00:12:43,360
+الـ Alpha ولا في الـ Beta ماحنا عارفين إن الـ
+
+142
+00:12:43,360 --> 00:12:48,900
+Hemoglobin A1 عبارة عن 4 بوليبطايد تشين سلسلتان
+
+143
+00:12:48,900 --> 00:12:54,820
+Alpha وسلسلتان Beta طيب، اللي بدنا نفهمه إنه أنا
+
+144
+00:12:54,820 --> 00:12:59,320
+بعينيني الـ Subform الـ Hemoglobin A1C اللي هو ما
+
+145
+00:12:59,320 --> 00:13:04,720
+يسمى بـ مخزون السكر هذا المُركّب كيف بتكون؟بتكون
+
+146
+00:13:04,720 --> 00:13:08,580
+انه زي ما انتوا شايفين بالرسمة لما بييجي جزاء
+
+147
+00:13:08,580 --> 00:13:14,900
+الجلوكوز ويربط في الـ Beta Chain هي مكتوب Beta A
+
+148
+00:13:14,900 --> 00:13:20,960
+يربط في الـ Beta Chain في المنطقة الترافية في
+
+149
+00:13:20,960 --> 00:13:27,440
+Amino Group يعني في حمض أمينيو معين ساعتها بتكون
+
+150
+00:13:27,440 --> 00:13:34,630
+لما يتحد الجلوكوز ويربط مع Hemoglobin A1ويربط معاه
+
+151
+00:13:34,630 --> 00:13:38,870
+في الـ Beta Chain ساعتها هيعطيني الـ Hemoglobin
+
+152
+00:13:38,870 --> 00:13:46,650
+A1C تمام؟ لكن في مركبات تانية مثلًا بيج السكر بربط
+
+153
+00:13:46,650 --> 00:13:52,430
+فيه Hemoglobinفي الـ Hemoglobin بس مش مثلا في الـ
+
+154
+00:13:52,430 --> 00:13:55,850
+Beta-Chain في الـ Alpha-Chain ساعتها بيعطيكي
+
+155
+00:13:55,850 --> 00:14:02,670
+Hemoglobin A1a و A1b ما بدنا نفوته بتفاصيل أهم إشي
+
+156
+00:14:02,670 --> 00:14:08,190
+بدنا نعرف إن جزء السكر بفوت جوات ال RBCs وبربط في
+
+157
+00:14:08,190 --> 00:14:13,490
+ال Hemoglobin A أو ما يسمى بالـ A1وين بالظبط بربط
+
+158
+00:14:13,490 --> 00:14:18,930
+في الـ Beta Chain في الأحماض الأمينية الموجودة في
+
+159
+00:14:18,930 --> 00:14:23,690
+الـ Beta Chain عشان في الآخر يعطيني الـ Hemoglobin
+
+160
+00:14:23,690 --> 00:14:30,950
+A1C تحت كتبلكم المراكبات ما بدنا نحفظهاتحت كتبلكوا
+
+161
+00:14:30,950 --> 00:14:37,230
+Hemoglobin A أو A1 ربط بي الجلوكوز العملية في
+
+162
+00:14:37,230 --> 00:14:42,870
+الأول بتكون ربط تعطيني مركب الـ Pre Hemoglobin A1c
+
+163
+00:14:42,870 --> 00:14:47,990
+بعد هيك العملية بتصير بطيقة و بتحول المركب لـ Pre
+
+164
+00:14:47,990 --> 00:14:53,010
+Hemoglobin A1c لهemoglobin A1c وهو المطلوب الـ
+
+165
+00:14:53,010 --> 00:14:57,830
+Hemoglobin A1c موجود جوات الاربيسيز بكميات كبيرة
+
+166
+00:14:58,300 --> 00:15:02,840
+أكتر من الـ Subforms الأخرى أكتر من الـ Hemoglobin
+
+167
+00:15:02,840 --> 00:15:09,520
+A1A والـ Hemoglobin A1B هدلّك طريقة ارتباط السكر
+
+168
+00:15:09,520 --> 00:15:16,240
+بالـ Hemoglobin من مواقع أخرى تمام؟ هذا اللي بدنا
+
+169
+00:15:16,240 --> 00:15:16,980
+نعرفه
+
+170
+00:15:19,890 --> 00:15:24,830
+الـ significance of a test يعني إيش الهدف من الفحص
+
+171
+00:15:24,830 --> 00:15:29,190
+إيش فايدة هذا الفحص اللي هو hemoglobin A1C فحص
+
+172
+00:15:29,190 --> 00:15:34,970
+مخزون السكر by testing for glycosylated hemoglobin
+
+173
+00:15:34,970 --> 00:15:38,890
+the doctor discovers what the average blood
+
+174
+00:15:38,890 --> 00:15:44,230
+glucose level has been for the previous اتنين لتلت
+
+175
+00:15:44,230 --> 00:15:51,520
+شهور من خلالفحص المركّب الـ Hemoglobin A1C اللي
+
+176
+00:15:51,520 --> 00:15:58,200
+اتكون كيف اتكون نتيجة دخول تركيز معين من السُكر
+
+177
+00:15:58,200 --> 00:16:05,420
+جوّات الـ RBCs ربطت بـ Hemoglobin A1 بجهة الـ Beta
+
+178
+00:16:05,420 --> 00:16:10,780
+-H chain وبالتالي أعطت مركّب اسمه Hemoglobin A1C
+
+179
+00:16:10,780 --> 00:16:15,880
+هذا اللي احنا بدنا نقيصه لمرضاء السُكري لأن هذا
+
+180
+00:16:15,880 --> 00:16:23,910
+المركّبوهذا الفحص بيبين للدكتور كيف كان مستوى
+
+181
+00:16:23,910 --> 00:16:30,490
+السكر عند مريض السكري قبل تلت شهور سابقة أو قبل
+
+182
+00:16:30,490 --> 00:16:36,560
+اتنين لتلت شهور يعني بدل ما احكيلمريض السكر انت كل
+
+183
+00:16:36,560 --> 00:16:42,820
+أسبوع أو كل شهر روح المستشفى سوري و اعمل fasting
+
+184
+00:16:42,820 --> 00:16:46,940
+blood sugar يعني اعمل فحص السكر عادي هيك تكلف عليه
+
+185
+00:16:46,940 --> 00:16:50,400
+و تعب عليه كل شهر بدي يروح يعمل فحص السكر عشان
+
+186
+00:16:50,400 --> 00:16:56,010
+انشيك على سكرهأنا بخلي كل تلت شهور يعمل فحص واحد
+
+187
+00:16:56,010 --> 00:17:01,510
+اللي هو مخزون السكر لو انت عملتي هذا الفحص بتقدري
+
+188
+00:17:01,510 --> 00:17:07,750
+تعرفي كيف كان مستوى السكر عند مريض السكري قبل تلت
+
+189
+00:17:07,750 --> 00:17:13,500
+شهور هل هذا المريض كان محافظ على نفسه ولا لأ؟لأنه
+
+190
+00:17:13,500 --> 00:17:17,160
+فعليًا بيجي مريض السكري على الدكتور بيقوله آه كيف
+
+191
+00:17:17,160 --> 00:17:22,300
+اعمل تحمية ما بتاكل أكلات دسمة فيها سكريات وحاجات
+
+192
+00:17:22,300 --> 00:17:27,120
+زي هيك بيقوله آه عمل تحميةطيب، بقولّه بنعملك مخزون
+
+193
+00:17:27,120 --> 00:17:33,140
+سُكر مخزون السُكر بكشف المريض هل هو بيكذب أو لأ
+
+194
+00:17:33,140 --> 00:17:39,460
+كيف أن هذا مخزون السُكر بيبين للدكتور إيش أو كيف
+
+195
+00:17:39,460 --> 00:17:45,020
+كان سُكر المريض قبل تلت شهور هل كان عالي؟ هل كان
+
+196
+00:17:45,020 --> 00:17:49,680
+كويس؟ ضمن ال range؟ هل كان هذا المريض بيخبص في
+
+197
+00:17:49,680 --> 00:17:56,050
+الأكل قبل تلت شهور ولا لأ؟ تمام؟هذا خصيصًا مهمًا
+
+198
+00:17:56,050 --> 00:18:03,250
+جدًا عند مراقبة ديابتس بحر دم يتغير جدًا من اليوم
+
+199
+00:18:03,250 --> 00:18:07,850
+إلى اليوم ومن خلال مراقبة تحكم ديابتك طويلًا هذا
+
+200
+00:18:07,850 --> 00:18:15,110
+الفحص له قيمة جيدة في مراقبة ومتابعة مرض السكري
+
+201
+00:18:15,110 --> 00:18:21,820
+اللي دايما سكرهم في حالة تذبذب، fluctuationواللي
+
+202
+00:18:21,820 --> 00:18:28,060
+دايماً سكرهم بتغير من يوم ليوم فمخزون السكر إله
+
+203
+00:18:28,060 --> 00:18:33,120
+قيمة هذا الفحص أيضاً من خلاله إحنا بنعمل مراقبة
+
+204
+00:18:33,120 --> 00:18:38,400
+بعيدة المدى إيش يعني؟ يعني لفترة طويلة يعني أنا
+
+205
+00:18:38,400 --> 00:18:42,640
+مثلا كل تلت شهور بقوله روح اعمل مخزون السكر بيروح
+
+206
+00:18:42,640 --> 00:18:49,240
+بعمل الفحص نتيجة الفحص بتعبر كيف كانسُكره قبل تلت
+
+207
+00:18:49,240 --> 00:18:54,380
+شهور انتبهوا previously قبل مش بعد تلت شهور قبل
+
+208
+00:18:54,380 --> 00:19:00,900
+تلت شهور كيف كان سُكر المريض Hemoglobin A1C are a
+
+209
+00:19:00,900 --> 00:19:05,220
+bitter and less expensive measure of long term
+
+210
+00:19:05,220 --> 00:19:09,940
+glucose control than repeated fasting glucose هلجي
+
+211
+00:19:09,940 --> 00:19:17,060
+تفحص مخزون السُكر أفضل وأقل في التكلفة من fasting
+
+212
+00:19:17,060 --> 00:19:20,780
+blood sugar هلجيت لو انت كل شهر بدك تطلب من مريض
+
+213
+00:19:20,780 --> 00:19:24,600
+السكر يعمل فحص السكر يعمل ال fasting blood sugar
+
+214
+00:19:24,600 --> 00:19:28,660
+هذا مكلف يا جماعة كل شهر بدي يعمل فحص كل شهر بدي
+
+215
+00:19:28,660 --> 00:19:33,420
+يعمل فحص أنا بوفر عليه بخليه كل 3 شهور يعمل الفحص
+
+216
+00:19:33,420 --> 00:19:39,280
+إذا مخزون السكر أقل تكلفة وأفضل من ال fasting
+
+217
+00:19:39,280 --> 00:19:45,770
+blood sugar لأنه already بيعطيناتوجهات كيف كانت
+
+218
+00:19:45,770 --> 00:19:50,530
+مستويات السكر عند المريض قبل ثلاث شهور سابقة
+
+219
+00:19:52,200 --> 00:19:56,300
+affected by exercise or recent food ingestion برضه
+
+220
+00:19:56,300 --> 00:20:00,500
+هذا الفحص ما بتأثر بيه أي exercise ممكن أكون أنا
+
+221
+00:20:00,500 --> 00:20:06,200
+عاملة جهد و أروح أعمله عادي وأيضا لا يشترط فيه صوم
+
+222
+00:20:06,200 --> 00:20:10,580
+يعني عادي لو ماكنت صايمة بقدر مريض السكر يعمله حتى
+
+223
+00:20:10,580 --> 00:20:15,040
+لو ماكان صايم على خلاف فحص ال fasting blood sugar
+
+224
+00:20:15,040 --> 00:20:23,650
+بتطلب إنك تكون صايمإذاً حابة أأكد على شغل إنه بشكل
+
+225
+00:20:23,650 --> 00:20:28,830
+طبيعي عملية طبيعية بتسير في الجسم بتسير بشكل بطيء
+
+226
+00:20:28,830 --> 00:20:35,570
+ما بدها أنزيمات وبشكل irreversible إنه تركيز معين
+
+227
+00:20:35,570 --> 00:20:41,590
+من السكر في الدم بيروحه هو داخل جوات خلايا الـRBCs
+
+228
+00:20:41,590 --> 00:20:47,090
+بدنا نتخيل الميكانزم جوات الـRBCs فيه تلاتة همجلب
+
+229
+00:20:47,090 --> 00:20:52,680
+أساسياتHemoglobin A1 و Hemoglobin A2 و Hemoglobin
+
+230
+00:20:52,680 --> 00:20:59,490
+F وقلنا إن Hemoglobin A1 هو نفسه Hemoglobin Aهلجت
+
+231
+00:20:59,490 --> 00:21:05,310
+لما بيفوت السكر جوات الـ RBCs جزيئات السكر بتروح
+
+232
+00:21:05,310 --> 00:21:10,950
+ترتبط مع Hemoglobin A1 لو السكر ارتبط مع
+
+233
+00:21:10,950 --> 00:21:16,650
+Hemoglobin A1 بالـ Beta Chain تبعته هيتكون مركب
+
+234
+00:21:16,650 --> 00:21:21,770
+اسمه الـ Hemoglobin A1C هذا اللي احنا بنسميه مخزون
+
+235
+00:21:21,770 --> 00:21:27,150
+السكر بنسميه Glycated Hemoglobin Hemoglobin مربوط
+
+236
+00:21:27,150 --> 00:21:31,580
+بجلوكوزأو Glycosylated Hemoglobin نفس المسمى
+
+237
+00:21:31,580 --> 00:21:37,200
+Hemoglobin مربوط بالسكر من جهة الـ Beta Etching
+
+238
+00:21:38,500 --> 00:21:44,080
+وبرضه تتكون مركبات أخرى Hemoglobin A1A و
+
+239
+00:21:44,080 --> 00:21:51,560
+Hemoglobin A1B بس هذه كيف بتتكون أن السكر بربط مع
+
+240
+00:21:51,560 --> 00:21:56,420
+Hemoglobin A1 ولكن مش في الـ Beta Chain في مثلا
+
+241
+00:21:56,420 --> 00:22:02,120
+سلاسل Alpha Chain تمام؟ بس مابدنا تفاصيل وتركيزها
+
+242
+00:22:02,120 --> 00:22:09,720
+بتكون قليلة بس الأكتر بتكون الـ Hemoglobin A1Cالـ
+
+243
+00:22:09,720 --> 00:22:13,980
+Blood Levels of Glycated Hemoglobin Dependence
+
+244
+00:22:13,980 --> 00:22:19,780
+هالجيت نسبة Hemoglobin A1C اللي هو الـ Hemoglobin
+
+245
+00:22:19,780 --> 00:22:25,020
+اللي ارتبط بالسكر نسبته في الجسم تعتمد على شو؟
+
+246
+00:22:25,020 --> 00:22:30,700
+تعتمد على شغلتين أساسيات الـ Lifespan للـ RBCs
+
+247
+00:22:30,700 --> 00:22:34,400
+والـ Blood Glucose Concentration الركز في اللي تحت
+
+248
+00:22:34,400 --> 00:22:40,480
+وبعدين نطلع باللي فوقأذن تركيز ونسبة Hemoglobin
+
+249
+00:22:40,480 --> 00:22:46,320
+A1C اللي هو مخزون السكر يعتمد تركيزه على شغلتان
+
+250
+00:22:46,320 --> 00:22:52,340
+على تركيز السكر في الدم وعلى عمر الـRBCs تركيز
+
+251
+00:22:52,340 --> 00:22:58,870
+السكر في الدمهل جيت لو أنا إنسان مثلا عنده ضيابيتس
+
+252
+00:22:58,870 --> 00:23:03,290
+ماليتس عنده مرض سكري يعني السكر عنده في الدم يا
+
+253
+00:23:03,290 --> 00:23:07,730
+جماعة اش بدي يكون كتير عالي عالي كتير فوق الـ180
+
+254
+00:23:07,730 --> 00:23:13,860
+مثلا تمام، هل جيت؟كمية السكر اللي هتفوت داخل الـ
+
+255
+00:23:13,860 --> 00:23:19,400
+RBCs هتكون مهولة أكتر من الطبيعي متخيلين؟ شخص مريض
+
+256
+00:23:19,400 --> 00:23:23,200
+سكري معناه إنه في الـ blood تبعه، في الدم تبعه
+
+257
+00:23:23,200 --> 00:23:27,560
+السكر عالي كتير وبالتالي كمية السكر اللي هتفوت
+
+258
+00:23:27,560 --> 00:23:33,580
+جوات الـ RBCs هتكون كميتها كتير كبيرة سكر كتير دخل
+
+259
+00:23:33,580 --> 00:23:40,090
+الـ RBCsمعناها يرتبط بشكل أكبر مع Hemoglobin A1
+
+260
+00:23:40,090 --> 00:23:47,210
+معناها ينتج عندي مركب Hemoglobin A1C بكميات أكبر
+
+261
+00:23:47,210 --> 00:23:53,690
+من الوضع الطبيعي وبالتالي بتخيل مريض السكري لما
+
+262
+00:23:53,690 --> 00:23:57,910
+أجي أفحصل مخزون السكر اللي هو مركب الـ Hemoglobin
+
+263
+00:23:57,910 --> 00:24:05,350
+A1C هلاقي نسبة هذا المركب عالي جدا صح ولا لأ؟طيب،
+
+264
+00:24:05,350 --> 00:24:10,710
+نفهم العكس أنا إنسان سليم السكر عندي في الدم طبيعي
+
+265
+00:24:10,710 --> 00:24:17,570
+معناه إن كمية السكر اللي هتفوت جوات الـRBCs هتكون
+
+266
+00:24:17,570 --> 00:24:23,070
+ضمن الـRange طبيعية هتفوت وتدخل .. هتدخل وتفوت
+
+267
+00:24:23,070 --> 00:24:29,260
+جوات الـRBCs وترتبط معه مجلباً A1واتكون Hemoglobin
+
+268
+00:24:29,260 --> 00:24:34,320
+A1C يعني هيتكون هذا المركب الـ Hemoglobin A1C
+
+269
+00:24:34,320 --> 00:24:41,100
+بتركيز طبيعي بنسبة طبيعية على خلاف مريض السكري
+
+270
+00:24:41,100 --> 00:24:46,970
+مريض السكريهيكون عنده مخزون السكر عالي لأنه أصلا
+
+271
+00:24:46,970 --> 00:24:52,630
+تركيزه السكر في الدم عالي فهيفوض سكر أكتر جوات الـ
+
+272
+00:24:52,630 --> 00:24:56,990
+herpeses ويتكون مركب الـ hemoglobin A1C بكميات
+
+273
+00:24:56,990 --> 00:25:03,890
+أكبر إذن كل ما زاد مستوى السكر في الدم كل ما زادت
+
+274
+00:25:03,890 --> 00:25:10,430
+نسبة الـ hemoglobin A1C كل ما زاد نسبة تكوينه،
+
+275
+00:25:10,430 --> 00:25:16,260
+تمام؟أيضًا الـ lifespan للـ RBCs كلنا عارفين إن
+
+276
+00:25:16,260 --> 00:25:23,040
+عمر خلاية دم الحمرة 3 شهور، 120 يوم صح ولا مش صح؟
+
+277
+00:25:23,040 --> 00:25:29,450
+تمام تخيلوا شخص عنده Hemolytic Anemiaيعني عنده الـ
+
+278
+00:25:29,450 --> 00:25:34,030
+RBCs اللي بتتكون تتكسر عطول يعني ال life span اللي
+
+279
+00:25:34,030 --> 00:25:39,050
+لها قصير ال RBCs اللي بتطلع الدم بسرعة تتكسر معناه
+
+280
+00:25:39,050 --> 00:25:44,250
+الكلام السكر اللي في الدم تبع الإنسان مش هيكون
+
+281
+00:25:44,250 --> 00:25:50,410
+جادر يفوت جواد خلايا الدم الحمرة ويربط به مغلوب A1
+
+282
+00:25:50,520 --> 00:25:55,500
+ويكوّن Hemoglobin A1C صح ولا لأ؟ لأن الـRBCs على
+
+283
+00:25:55,500 --> 00:26:00,960
+طول بتتكسر ففيش فرصة للسكر يفوت جواها ويدخل بالـ
+
+284
+00:26:00,960 --> 00:26:06,580
+Hemoglobin وبالتالي نسبة Hemoglobin A1C هتكون
+
+285
+00:26:06,580 --> 00:26:12,410
+قليلة، أصلا مش هيتكون المُركّبتمام؟ مش هيتكون
+
+286
+00:26:12,410 --> 00:26:16,470
+مركّب الـ Hemoglobin A1C لأن خلايا الدم الحمرا
+
+287
+00:26:16,470 --> 00:26:24,190
+بسرعة بتتكسّر إذن عمر الـ RBCs برضه بيحدد .. بيحدد
+
+288
+00:26:24,190 --> 00:26:30,210
+ويله دور في إنه يحدد تركيز المركّب الـ Hemoglobin
+
+289
+00:26:30,210 --> 00:26:37,140
+A1C إذن عمر الـ RBCs وتركيز السكر في الدمهدولة
+
+290
+00:26:37,140 --> 00:26:45,460
+بيحددوا تركيز Hemoglobin A1C عند الإنسان الـ
+
+291
+00:26:45,460 --> 00:26:49,080
+specimen نبدأ بالعينة إجاني شخص بدي يعمل فحث
+
+292
+00:26:49,080 --> 00:26:52,820
+Hemoglobin A1C هيك بيجي في ال request Hemoglobin
+
+293
+00:26:52,820 --> 00:26:57,980
+A1C يعني مخزون السكر إيديتا is the anticoagulant
+
+294
+00:26:57,980 --> 00:27:01,820
+of its choice for all method طبعا مخزون السكر
+
+295
+00:27:01,820 --> 00:27:07,940
+بنعمل يا جماعة بأكتر من طريقةكل الطرق نوع العينة
+
+296
+00:27:07,940 --> 00:27:13,220
+المسموح فيها هي holy blood لا serum ولا plasma
+
+297
+00:27:13,220 --> 00:27:16,660
+بطلنا و بدناش نشتغل لا serum ولا plasma لما بدك
+
+298
+00:27:16,660 --> 00:27:21,900
+تعمل فحص مخزون السكر نوع العينة تبعتي holy blood
+
+299
+00:27:21,900 --> 00:27:28,180
+تمام؟ ليش؟أنا بدي الـ Hemoglobin A1C هذا المُركّب
+
+300
+00:27:28,180 --> 00:27:32,820
+هذا المُركّب وين موجود؟ وين بتكون؟ جوات الـ RBCs
+
+301
+00:27:32,820 --> 00:27:37,560
+إذا لازم أنا عينت تكون Holy Blood دم، خلايا دم
+
+302
+00:27:37,560 --> 00:27:43,560
+حمرة، صح ولا لأ؟ عشان أخدها و أكسرها و أطلع منها
+
+303
+00:27:43,560 --> 00:27:49,640
+الـ Hemoglobin A1C عشان أجيصه صح ولا مش صح؟تمام،
+
+304
+00:27:49,640 --> 00:27:54,900
+هذا الـ holy blood بأجمعه في anticoagulant نوع الـ
+
+305
+00:27:54,900 --> 00:27:59,380
+anticoagulant المفضل هي الـ Edeta يعني بتجيبي من
+
+306
+00:27:59,380 --> 00:28:02,960
+الأنابيب اللي لون الـ cover تبعهم الـ move و بتحطي
+
+307
+00:28:02,960 --> 00:28:07,360
+holy blood و بتعملي mix no special preparation
+
+308
+00:28:07,360 --> 00:28:11,520
+fasting specimen are not required يعني مافي تحضير
+
+309
+00:28:11,520 --> 00:28:18,060
+للمريض مافي أي تعليمات للفحص الصوم مش ضروري تمام
+
+310
+00:28:19,210 --> 00:28:23,850
+معظم الأسلحة تحتاج إلى أسلحة مع مجهود مجهود مجهود
+
+311
+00:28:23,850 --> 00:28:24,570
+مجهود مجهود مجهود مجهود مجهود مجهود مجهود مجهود
+
+312
+00:28:24,570 --> 00:28:28,190
+مجهود مجهود مجهود مجهود مجهود مجهود مجهود مجهود
+
+313
+00:28:28,190 --> 00:28:28,410
+مجهود مجهود مجهود مجهود مجهود مجهود مجهود مجهود
+
+314
+00:28:28,410 --> 00:28:28,950
+مجهود مجهود مجهود مجهود مجهود مجهود مجهود مجهود
+
+315
+00:28:28,950 --> 00:28:28,950
+مجهود مجهود مجهود مجهود مجهود مجهود مجهود مجهود
+
+316
+00:28:28,950 --> 00:28:48,230
+مجهود مجهود مجهود مجهود مجهود مجهود مجهود مجهود م
+
+317
+00:28:48,250 --> 00:28:52,630
+وانا مين بدي اجيس الـ Hemoglobin A1C مخزون السكر
+
+318
+00:28:52,630 --> 00:28:56,810
+اللي موجود جوات الـ RBCs طبعا الـ Hemolysing
+
+319
+00:28:56,810 --> 00:29:01,290
+reagent بيجي من الـ Manufacturer من الشركة، تمام؟
+
+320
+00:29:02,540 --> 00:29:06,540
+typically holy blood may be stored up to seven
+
+321
+00:29:06,540 --> 00:29:11,740
+days at اتنين لتمانية درجة سيليزيا هلجيت انت ممكن
+
+322
+00:29:11,740 --> 00:29:16,500
+تجمعي holy blood من المريض بتحطيها في انبوبة
+
+323
+00:29:16,500 --> 00:29:22,900
+الاديتا وممكن تخزن العينة في التلاجة لمدة سبع أيام
+
+324
+00:29:22,900 --> 00:29:27,520
+تمام؟ تحفظ في درجة حرارة التلاجة لمدة سبع أيام في
+
+325
+00:29:27,520 --> 00:29:32,970
+أي وجهة بتشتغل الفحصطيب فقط الـ E-DETA المسموح
+
+326
+00:29:32,970 --> 00:29:36,770
+فيها كـ Anticoagulant لأ الـ Hibarinoid sample
+
+327
+00:29:36,770 --> 00:29:42,170
+يعني ممكن أستخدم الـ Anticoagulant الهيبارين مش بس
+
+328
+00:29:42,170 --> 00:29:46,190
+الـ E-DETA بس فيه يعني limitation لإستخدام
+
+329
+00:29:46,190 --> 00:29:52,020
+الهيبارينshould be assayed within two days and
+
+330
+00:29:52,020 --> 00:29:55,180
+maybe not suitable for other methods الـ
+
+331
+00:29:55,180 --> 00:29:58,300
+Electrophoresis لو أنت بدك تجمع الـ holy blood
+
+332
+00:29:58,300 --> 00:30:04,000
+بهيبارين خلال يومين بدك تشتغل الفحص يعني ما تتخذن
+
+333
+00:30:04,000 --> 00:30:10,410
+العينة في التلاجة سبع أيام فقط ليومينأيضًا لما أنا
+
+334
+00:30:10,410 --> 00:30:15,010
+حكيتلكوا إن مخزون السكر ممكن أنا أستخدم أكتر من
+
+335
+00:30:15,010 --> 00:30:19,930
+طريقة عشان أشتغله، صح ولا لأ؟ هلجيت لو أنا بطريقة
+
+336
+00:30:19,930 --> 00:30:25,630
+الـelectrophoresis، الفصل بالكهربا، بدي أحسبنسبة
+
+337
+00:30:25,630 --> 00:30:29,650
+الـ hemoglobin A1C اللي هو مخزون السكر بيعبر عن
+
+338
+00:30:29,650 --> 00:30:35,530
+مخزون السكر ممنوع أجمع عينتي بالهيبرين، ممنوع يعني
+
+339
+00:30:35,530 --> 00:30:39,510
+مابيعطيني نتائج بالمرة، لازم بالـ Edita عشان هيك
+
+340
+00:30:39,510 --> 00:30:46,900
+بنقولكوا الـ Edita مناسبة لكل الطرق آخر ملاحظةالـ
+
+341
+00:30:46,900 --> 00:30:51,740
+blood glucose level reflects the previous few
+
+342
+00:30:51,740 --> 00:30:58,060
+hours glycemic state جزده هنا ال fasting blood
+
+343
+00:30:58,060 --> 00:31:02,300
+glucose الفحص اللي لازم تكوني انت صايمة تمان ساعات
+
+344
+00:31:02,300 --> 00:31:10,060
+قبل ما تعملي هذا يعبرلك هذا الفحص انه كم كان سكرك
+
+345
+00:31:10,060 --> 00:31:17,590
+خلال ساعات سابقة تمام؟هل جيت احنا لما نحكيلك بدنا
+
+346
+00:31:17,590 --> 00:31:21,330
+تعملينا ال fasting blood sugar بتروح تصومي تمام
+
+347
+00:31:21,330 --> 00:31:25,630
+ساعات و بتيجي تعمل الفحص هل جيت هذا الفحص ما
+
+348
+00:31:25,630 --> 00:31:32,230
+بيعطيني indication مؤشر انه كيف كان سكرك قبل أشهر
+
+349
+00:31:32,530 --> 00:31:38,850
+تمام؟ فقط بيعطيني مؤشر انه جداش كان سُكرك قبل
+
+350
+00:31:38,850 --> 00:31:44,150
+ساعات قليلة يعني قبل عشر ساعات قبل اتناشر ساعة
+
+351
+00:31:44,150 --> 00:31:50,820
+جداش كان سُكرك تمام؟في عندي حاجة اسمها الـGlycated
+
+352
+00:31:50,820 --> 00:31:56,720
+albumin هذه برضه جديدة عليكم برضه عملية طبيعية زي
+
+353
+00:31:56,720 --> 00:32:02,940
+ما السكر بيفوت جوات الـRBCs وبربط بهيموجلوبين A1 و
+
+354
+00:32:02,940 --> 00:32:08,480
+بيكوّل لمراكب مخزون السكر اسمه هيموجلوبين A1C هذه
+
+355
+00:32:08,480 --> 00:32:14,540
+عملية طبيعيةنفس الأشي جذيئات من السكر ترتبط
+
+356
+00:32:14,540 --> 00:32:20,640
+ببروتين اسمه الـ albumin في الدم وبتكون مركب اسمه
+
+357
+00:32:20,640 --> 00:32:24,880
+الـ glycated albumin albumin عبارة عن البروتين
+
+358
+00:32:24,880 --> 00:32:29,340
+albumin glycated albumin معناه albumin مرتبط
+
+359
+00:32:29,340 --> 00:32:35,500
+بالجلوكوزهذا الـ Glycated album في دراسات حديثة
+
+360
+00:32:35,500 --> 00:32:42,020
+جالوا إنه ممكن ينعمل لمرضى السكري عشان انتبع سكرهم
+
+361
+00:32:42,730 --> 00:32:50,170
+وبيعطيكي مؤشر إنه كيف كان السكر عند مريض السكري
+
+362
+00:32:50,170 --> 00:32:56,650
+جابل 14 يوم يعني جابل أسبوعين إذا هذا فحص ممتاز
+
+363
+00:32:56,650 --> 00:33:01,430
+بيعطيني Monitoring مراقبة لمرضى السكري كيف كان
+
+364
+00:33:01,430 --> 00:33:07,050
+سكرهم جابل 14 يوم جابل أسبوعين إذا فحص برضه ممتاز
+
+365
+00:33:08,620 --> 00:33:11,300
+اقرأوا عنه يا جماعة يعني ممكن انا اعطيكوا الـ
+
+366
+00:33:11,300 --> 00:33:15,360
+homework عن الـ glycated albumin نفس الطريقة بيجي
+
+367
+00:33:15,360 --> 00:33:18,980
+السكر في الدم برتبط في ال albumin أيضا موجود في
+
+368
+00:33:18,980 --> 00:33:23,040
+الدم وبيعطيني مركب اسمه glycated albumin نيجي احنا
+
+369
+00:33:23,040 --> 00:33:27,280
+الطريقة نانجيص ال glycated albumin عند مرضى السكري
+
+370
+00:33:28,830 --> 00:33:33,870
+تمام؟ أكيد هيطلع عندهم عالي ليش؟ ليش عالي؟ ما هو
+
+371
+00:33:33,870 --> 00:33:40,370
+أكيد عالي لأن سكرهم أصلا في الدم عالي فسكر كتير في
+
+372
+00:33:40,370 --> 00:33:45,610
+الدم معناه هييجي السكر ويرتبط بكميات كبيرة مع
+
+373
+00:33:45,610 --> 00:33:49,730
+الألبومين إذا المحصلة هيتكون مركبة لـGlycated
+
+374
+00:33:49,730 --> 00:33:57,020
+album بتركيز كبيرأيضًا Hemoglobin A1C أنا بستخدمه
+
+375
+00:33:57,020 --> 00:34:03,160
+لمرضى السُكري هو مؤشر إنه كيف كان السُكر عند مريض
+
+376
+00:34:03,160 --> 00:34:09,320
+السُكري قبل 3 شهور سابقة إذًا، يعني لو نيجي
+
+377
+00:34:09,320 --> 00:34:12,880
+نسألكوا سؤال، برضه هذا هيكون من ضمن الـHomework
+
+378
+00:34:12,880 --> 00:34:18,140
+مين أفضل أعمل متابعة كل أسبوعين لمرضى السُكري
+
+379
+00:34:18,140 --> 00:34:22,820
+أشتغليلهم لـGlycated albuminولّا أعمل متابعة كل
+
+380
+00:34:22,820 --> 00:34:30,240
+تلت شهور لمرضى السكري واشتغللهم مخزون السكر الـ
+
+381
+00:34:30,240 --> 00:34:35,320
+Hemoglobin A1C إذن الـ Hemoglobin A1C هو الـ
+
+382
+00:34:35,320 --> 00:34:41,320
+longest يعني بيعطيني مؤشر لفترات طويلة لتلت شهور
+
+383
+00:34:41,320 --> 00:34:45,880
+لـGlycated album لسبوعين ال fasting blood sugar مش
+
+384
+00:34:45,880 --> 00:34:49,180
+نافع كتير لساعات معينة تمام؟
+
+385
+00:34:52,720 --> 00:34:57,640
+حكيتلكوا إنه مخزون السكر فحص الـ Hemoglobin A1C
+
+386
+00:34:57,640 --> 00:35:02,700
+بقدر أشتغله بطرق مختلفة الجل الـ Electrophoresis
+
+387
+00:35:02,700 --> 00:35:07,260
+طريقة الفصل بالكهربا الـ Immunoassay بطرق مناعية
+
+388
+00:35:07,260 --> 00:35:12,020
+أو الـ Affinity Chromatography أو بالطريقة الشائعة
+
+389
+00:35:12,020 --> 00:35:15,580
+في كل مختبراتنا اللي هي الـ Cation Exchange
+
+390
+00:35:15,580 --> 00:35:17,180
+Chromatography
+
+391
+00:35:19,090 --> 00:35:22,810
+طريقة الـ Cationic X-Change Chromatography معظم
+
+392
+00:35:22,810 --> 00:35:27,670
+كتاتنا بتفحص مخزون السكر بهذه الطريقة هذه الطريقة
+
+393
+00:35:27,670 --> 00:35:33,130
+بتعتمد على شغلتان تعتمد إنه كل الـ Hemoglobin
+
+394
+00:35:33,130 --> 00:35:38,530
+هتاخد الشحنة الموجبة تمام؟ كل الـ Hemoglobins اللي
+
+395
+00:35:38,530 --> 00:35:43,090
+موجودة جوا الـ RVCs بما فيها اللي أنا بدي أفحصه
+
+396
+00:35:43,090 --> 00:35:48,720
+الـ Hemoglobin A1C كله هياخد الشحنة الموجبةولكن
+
+397
+00:35:48,720 --> 00:35:53,680
+بيختلفوا في قوة الشحنة تمام؟ بيختلفوا في قوة
+
+398
+00:35:53,680 --> 00:36:01,780
+الشحنة مثلًا Hemoglobin F شحنته الموجبة عالية جدًا
+
+399
+00:36:01,780 --> 00:36:08,100
+قوية Hemoglobin A1C هتكون شحنته okay موجب ولكن
+
+400
+00:36:08,100 --> 00:36:13,700
+الموجبية طبعته ضعيفة شحنته ضعيفةأذن الـ Hemoglobin
+
+401
+00:36:13,700 --> 00:36:20,300
+variants أنواع الـ Hemoglobin هيتم
+
+402
+00:36:20,300 --> 00:36:26,260
+فصل الـ Hemoglobin بناء على الاختلاف بقوة الشحنة
+
+403
+00:36:27,660 --> 00:36:33,420
+وشغلة تانية مهمة في الـ «Cation Exchange Reason»
+
+404
+00:36:33,420 --> 00:36:38,360
+يعني نفهم إن الشغل عبارة عن كولوم وحيكون جواته
+
+405
+00:36:38,360 --> 00:36:42,840
+مادة الـ Reason وهذا الـ Reason هيكون حامل الـ
+
+406
+00:36:42,840 --> 00:36:47,700
+Negative Charge الشحنة السالبة والهيموجلب كلها
+
+407
+00:36:47,700 --> 00:36:54,970
+هتكون حاملة الشحنة الموجبةتمام؟ أذكركوا بنفس طريقة
+
+408
+00:36:54,970 --> 00:36:58,230
+Hemoglobin A2 اللي أخدناها في الهيماتولوجيا
+
+409
+00:36:58,230 --> 00:37:03,850
+وخلّاناكوا تشتغلوا عملي و تحسبوا نسبته صح ولا لأ؟
+
+410
+00:37:03,850 --> 00:37:07,870
+مش اشتغلنا على الـ column وكسرناه من تحت وكان
+
+411
+00:37:07,870 --> 00:37:14,070
+جواته مادة أبيض مادة بيضة Reason سمناها الـ Reason
+
+412
+00:37:14,070 --> 00:37:17,970
+وهذا الـ Reason كان محصور بين two filter paper
+
+413
+00:37:17,970 --> 00:37:24,350
+تتذكرواإذا الشغل عبارة عن Column هنشتغل على الـ
+
+414
+00:37:24,350 --> 00:37:31,350
+Column مبدأ طريقتنا بكل بساطة إنه بتجيبي Holy
+
+415
+00:37:31,350 --> 00:37:35,390
+Blood تسحبي من الوريد Holy Blood للمريض وبتحط الـ
+
+416
+00:37:35,390 --> 00:37:39,490
+Holy Blood في انبوبة الـ Edita وبتعملي Mix منيح
+
+417
+00:37:39,490 --> 00:37:45,790
+تمام؟ بعد هيك بتروحي تاخدي شوية من هذه العينة
+
+418
+00:37:46,190 --> 00:37:50,850
+وبتضيف عليها الـ Hemolysing Reagent تمام؟ اللي
+
+419
+00:37:50,850 --> 00:37:55,570
+هيبدأ يشتغل على الـ RBCs ويكسرها ويعمل لي
+
+420
+00:37:55,570 --> 00:37:59,490
+releasing للـ Hemoglobins وبالتالي طلعت الـ
+
+421
+00:37:59,490 --> 00:38:03,980
+Hemoglobins من الـ RBCsالـ Hemolysing Reagent
+
+422
+00:38:03,980 --> 00:38:08,460
+الوظيفتين قسّر الـ RBCs عشان يعمل Releasing للـ
+
+423
+00:38:08,460 --> 00:38:13,440
+Hemoglobin أيضًا وظيفته أنه يعطي كل الـ
+
+424
+00:38:13,440 --> 00:38:17,980
+Hemoglobins الشحنة الموجبة وظيفته أيضًا يوحد
+
+425
+00:38:17,980 --> 00:38:23,260
+الشحنة تاعت الـ Hemoglobins وكلهم يحملوا الشحنة
+
+426
+00:38:23,260 --> 00:38:29,000
+الموجبة، تمام؟هل جت كل الـ Hemoglobins صارت شحنتهم
+
+427
+00:38:29,000 --> 00:38:34,780
+موجبة؟ لما بحط عينتي هل جت الـ Hemolysate هذا اللي
+
+428
+00:38:34,780 --> 00:38:39,100
+صار في الـ Hemoglobin اللي حامل الشحنة الموجبة لما
+
+429
+00:38:39,100 --> 00:38:44,240
+حطه على الـ resin جوات الـ columnهلجيت؟ بما أن الـ
+
+430
+00:38:44,240 --> 00:38:49,440
+Hemoglobins كلها موجب والرزن شحناته ثانبة، حيصير
+
+431
+00:38:49,440 --> 00:38:54,660
+فيه ارتباط ما بين الـ Hemoglobins وما بين الرزن،
+
+432
+00:38:54,660 --> 00:38:58,280
+صح ولا لأ؟ نفس ما أخدنا في الـ Hematology، إذا
+
+433
+00:38:58,280 --> 00:39:03,020
+فاكرين هلجيت؟ أنا بدي أحسب أي نوع من أنواع الـ
+
+434
+00:39:03,020 --> 00:39:06,660
+Hemoglobin، بدي أحسب تركيزه بدي أحسب الـ
+
+435
+00:39:06,660 --> 00:39:12,290
+Hemoglobin A1C، مخزون السكروهذا مخزون السكر الـ
+
+436
+00:39:12,290 --> 00:39:18,250
+Hemoglobin A1C قالوا إن شحنته موجدة ولكن قوة
+
+437
+00:39:18,250 --> 00:39:25,070
+الشحنة ضعيفة يعني لو أضفت Reagent معين على الـ
+
+438
+00:39:25,070 --> 00:39:30,410
+Column هيؤدى هذا الـ Reagent إلى فك الـ Hemoglobin
+
+439
+00:39:30,410 --> 00:39:37,270
+A1C عن الرزن هيفك وينزل تحت، تمام؟ينزل في تيوب
+
+440
+00:39:37,270 --> 00:39:42,550
+فارغة باخد هذه التيوب وبتأكد إنه موجود فيها الـ
+
+441
+00:39:42,550 --> 00:39:46,970
+Hemoglobin A1C وبروح أقرأه على جهاز الـ
+
+442
+00:39:46,970 --> 00:39:51,470
+Spectrophotometer بنفس طريقة الـ Hemoglobin A2 إذا
+
+443
+00:39:51,470 --> 00:39:56,930
+فاكرين، تمام؟ إذا أنا هنا عملت له Illusion فكته عن
+
+444
+00:39:56,930 --> 00:40:02,950
+الرزن عشان بدي أحسب نسبته في الجسمبعد تحضير الـ
+
+445
+00:40:02,950 --> 00:40:06,950
+Hemolysate بعد ما تحضر الـ Hemolysate حيث تم إزالة
+
+446
+00:40:06,950 --> 00:40:12,930
+الفرق اللابالي وكمان بنزيل بقايا الـ RBCs اللي
+
+447
+00:40:12,930 --> 00:40:18,830
+متكسرة Hemoglobins are retained by a cation
+
+448
+00:40:18,830 --> 00:40:22,830
+exchange resin الـ Hemoglobin هتظل رابطة بالرزن
+
+449
+00:40:22,830 --> 00:40:28,250
+لأن شحنتها موجبة والرزن سالب Hemoglobin A1C is
+
+450
+00:40:28,250 --> 00:40:35,040
+specificallyالـ Eluted after washing away الـ
+
+451
+00:40:35,040 --> 00:40:40,660
+hemoglobin A1A وA1B fraction بعدين hemoglobin A1C
+
+452
+00:40:40,660 --> 00:40:46,020
+بعمله اليوشن بفكه عن باقي أنواع الـ hemoglobins
+
+453
+00:40:46,020 --> 00:40:53,640
+and is quantified وبعد هيك directly بقيسه على جهاز
+
+454
+00:40:53,640 --> 00:41:00,800
+الـ spectrophotometer على 415 نانومترThe
+
+455
+00:41:00,800 --> 00:41:04,020
+estimation of the relative concentration of
+
+456
+00:41:04,020 --> 00:41:08,820
+hemoglobin A1C is made by the measure of the total
+
+457
+00:41:08,820 --> 00:41:12,420
+hemoglobin concentration by direct photometric
+
+458
+00:41:12,420 --> 00:41:18,080
+reading at 415 nanometer هذا الكلام هنفهمه بالـ
+
+459
+00:41:18,080 --> 00:41:19,440
+procedure تمام؟
+
+460
+00:41:22,110 --> 00:41:27,810
+بس أهم إشي الركز على جثة إنه المبدأ المبدأ الـ
+
+461
+00:41:27,810 --> 00:41:31,470
+Resin سالب الـ Hemoglobin كلها موجب الـ Hemoglobin
+
+462
+00:41:31,470 --> 00:41:35,590
+اللي أنا بدياه Hemoglobin A1C الموجبية تبعته ضعيفة
+
+463
+00:41:35,590 --> 00:41:39,750
+كيف بفكه عن الـ Resin بضيف Reagent بعمل Elution
+
+464
+00:41:39,750 --> 00:41:44,290
+اللي بفكه باخده و بروح أقيصه مباشرة على الـ
+
+465
+00:41:44,290 --> 00:41:48,800
+Spectrophotometerإن شاء الله لما نرجع الجامعة
+
+466
+00:41:48,800 --> 00:41:53,300
+هنشتغلوا عمله الـ Hemoglobin A1C مخزون السكر الـ
+
+467
+00:41:53,300 --> 00:41:58,100
+procedure أول شغلة بتروح تجيبي tube بلاستيك و
+
+468
+00:41:58,100 --> 00:42:02,160
+بتسميها الـ Hemolysate هالجيت بتاخدي من الـ holy
+
+469
+00:42:02,160 --> 00:42:07,000
+blood اللي انجمع بعينة الـ EDTA بتاخدي منه خمسين
+
+470
+00:42:07,000 --> 00:42:11,620
+microliter بتحطيها في ال tube بلاستيك و بتحطي
+
+471
+00:42:11,620 --> 00:42:16,010
+عليها 200 microliterمن Reagent واحد هذا بيكون
+
+472
+00:42:16,010 --> 00:42:19,770
+موجود في الـ kit هالجيت Reagent واحد اسمه الـ
+
+473
+00:42:19,770 --> 00:42:25,790
+Hemolysate Reagent هيشتغل على ال blood ويبدأ يكسر
+
+474
+00:42:25,790 --> 00:42:29,890
+ال RBCs ويعمل releasing لل Hemoglobins ويعطي ال
+
+475
+00:42:29,890 --> 00:42:35,290
+Hemoglobins كلها الشحنة الموجبة يوحد شحنتها تمام؟
+
+476
+00:42:35,820 --> 00:42:40,480
+إذاً هذا الـ Hemolyse-Z preparation هذه أنبوبة الـ
+
+477
+00:42:40,480 --> 00:42:44,800
+Hemolyse-Z بعملها mix لما بحط الـ 50 على الـ 200
+
+478
+00:42:44,800 --> 00:42:50,400
+مايكرون بعمل mix منيح وبأترك هذه لتيوب مدة عشرة
+
+479
+00:42:50,400 --> 00:42:54,260
+لخمستاشر دقيقة at room temperature في درجة حرارة
+
+480
+00:42:54,260 --> 00:42:58,500
+الغرفة عشان أضمن إن الـ Hemolysing reagent كسر الـ
+
+481
+00:42:58,500 --> 00:43:04,240
+RBCs ووحد شحنة الـ Hemoglobins تمام؟ بعد ما بأترك
+
+482
+00:43:04,240 --> 00:43:10,150
+هذه لتيوببروح أحضر الـ Column كلنا عارفين تحضير
+
+483
+00:43:10,150 --> 00:43:15,990
+الـ Column أول إشي حكينا بنكسره من تحت عشان يبدأ
+
+484
+00:43:15,990 --> 00:43:21,250
+ينزل نقطة نقطة بنكسره من تحت إذا فاكرين ومن فوق
+
+485
+00:43:21,250 --> 00:43:25,910
+بنشيل الغطا تبعته جواته فيه buffer حكينا هذا الـ
+
+486
+00:43:25,910 --> 00:43:28,630
+buffer الفايدة منه أنه يحمي الـ Reason من أي
+
+487
+00:43:28,630 --> 00:43:33,900
+تغيراتبعدين بروح أجيب الـ Tube و بحطها تحت الـ
+
+488
+00:43:33,900 --> 00:43:39,220
+Column عشان يظلوا ينزلوا الـ Buffer نقطة نقطة بعد
+
+489
+00:43:39,220 --> 00:43:42,320
+ما ينزل الـ Buffer كله، أصلا هو بيكون جواة الـ
+
+490
+00:43:42,320 --> 00:43:47,260
+Buffer بعد ما ينزل الـ Buffer نقطة نقطةحكينا إنه
+
+491
+00:43:47,260 --> 00:43:51,340
+بتلاحظوا إنه عندي مادة الـ resin اللي بتحمل الشحنة
+
+492
+00:43:51,340 --> 00:43:56,540
+السالبة بتكون جاية بين طبقتين أو بين two filter
+
+493
+00:43:56,540 --> 00:44:00,560
+paper بيكون في filter paper فوق و filter paper تحت
+
+494
+00:44:00,560 --> 00:44:06,240
+و ال resin بالنصحكينا إيش بنعمل إذا فاكرين براس
+
+495
+00:44:06,240 --> 00:44:11,020
+الـ tip من فوق بتجيب الـ pipet و بتحط فيها tip و
+
+496
+00:44:11,020 --> 00:44:16,240
+من راس الـ tip بتنزلي الـ filter paper و بتضغطيها
+
+497
+00:44:16,240 --> 00:44:20,040
+على الـ resin بيصير عندي filter paper، resin،
+
+498
+00:44:20,040 --> 00:44:24,550
+filter paperهك الـ Column بيصير جاهز إذا الـ
+
+499
+00:44:24,550 --> 00:44:27,750
+Column بـ preparation الكلام اللي حكيتلكمياه بالـ
+
+500
+00:44:27,750 --> 00:44:32,050
+Slides حكيتلكمياه فعليا إيش بنشتغل إحنا بالشغل
+
+501
+00:44:32,050 --> 00:44:39,550
+العملية هك جاهز الـ Column للفصل، تمام؟ هلجيت الـ
+
+502
+00:44:39,550 --> 00:44:46,320
+Column اللي أنا حضرته، بروح أجيبهوبجيب الـ Plastic
+
+503
+00:44:46,320 --> 00:44:51,740
+Tube بحط الـ Column جواك الـ Plastic Tube وهذه الـ
+
+504
+00:44:51,740 --> 00:44:57,900
+Plastic Tube سموها الوس، سموها الفضلة، تمام؟ أول
+
+505
+00:44:57,900 --> 00:45:04,300
+خطوة، بتروحي تاخدي خمسين مايكرو ليتر من انبوبة الـ
+
+506
+00:45:04,300 --> 00:45:07,960
+Hemolyse-Z اللي حضرتها في الـ Slider الأولى من
+
+507
+00:45:07,960 --> 00:45:13,400
+انبوبة الـ Hemolyse-Zبروح أاخد خمسين microliter و
+
+508
+00:45:13,400 --> 00:45:19,600
+بحطها جواة ال column تمام؟ Lift the column drained
+
+509
+00:45:19,600 --> 00:45:24,660
+to west إذن أول خطوة بجيب plastic tube بكتب عليها
+
+510
+00:45:24,660 --> 00:45:29,390
+west بدخل فيها ال columnبروح باخد خمسين مايكرو
+
+511
+00:45:29,390 --> 00:45:33,050
+ليتر من الـ Hemolyse زيت اللي هالجيت على شو بيحتوي
+
+512
+00:45:33,050 --> 00:45:37,470
+بيحتوي على RBCs مكسرة وعلى الـ Hemoglobins كلها
+
+513
+00:45:37,470 --> 00:45:41,530
+باخد من الـ Hemolyse زيت خمسين مايكرون وبحقها فوق
+
+514
+00:45:41,530 --> 00:45:46,950
+ال columnبعد ما أحطها خطوة رقم 2 زي ما انتوا
+
+515
+00:45:46,950 --> 00:45:51,630
+شايفين في الـ slide بروح أجيب Reagent 2 بيكون
+
+516
+00:45:51,630 --> 00:45:56,630
+موجود في الـ kit عندنا بوتل اسمه Reagent 2 باخد من
+
+517
+00:45:56,630 --> 00:46:02,750
+هذا الـ Reagent 200 ميكروليتر و بحطها برضه فوق في
+
+518
+00:46:02,750 --> 00:46:07,530
+الـ column يعني فوق الـ 50 ميكروليتر بنحط 200
+
+519
+00:46:07,530 --> 00:46:16,980
+ميكروليترمن Reagent 2 وبخليه ينجط نقطة نقطة لحد ما
+
+520
+00:46:16,980 --> 00:46:23,620
+ينزل كل الـ Reagent إيش الفايدة من Reagent 2؟
+
+521
+00:46:23,620 --> 00:46:30,140
+بيحكيلي بيعمل على إذالة الـ RBCs المتكسرة مش
+
+522
+00:46:30,140 --> 00:46:32,780
+حاكينا الـ Hemolysate في RBC متكسرة وفي
+
+523
+00:46:32,780 --> 00:46:36,840
+Hemoglobins أنا بديش الـ RBC متكسرة تربط بالرزن
+
+524
+00:46:37,450 --> 00:46:41,690
+فبعد ما أنا حطيت الـ 50 µL في الـ column اللي هو
+
+525
+00:46:41,690 --> 00:46:46,470
+الـ Hemolysate بروح أحط 200 µL من الـ Reagent 2
+
+526
+00:46:46,470 --> 00:46:51,610
+هدفه إنه يشيل كل ال waste الفضلات ينزلها بما فيها
+
+527
+00:46:51,610 --> 00:46:57,200
+الـ RBCs المتكسرةوبعد ما ينزل الـ 200 نقطة نقطة
+
+528
+00:46:57,200 --> 00:47:04,500
+برضه بروح خطوة تلاتة أضيف من Reagent 2 2ML يعني
+
+529
+00:47:04,500 --> 00:47:08,940
+2000 microliter كمان بحطها فوق ال column و بخليه
+
+530
+00:47:08,940 --> 00:47:15,630
+يظل ينزل نقطة نقطة برضه الهدف من Reagent 2أكد إنه
+
+531
+00:47:15,630 --> 00:47:20,290
+تم إذالة كل الـ Waste، الفضلات وكل الـ RBCs
+
+532
+00:47:20,290 --> 00:47:24,730
+المتكسرة نزلت و بطلت عالقة في الـ Reason فقط اللي
+
+533
+00:47:24,730 --> 00:47:29,290
+رابط في الـ Reason هي أنواع الـ Hemoglobins، تمام؟
+
+534
+00:47:29,290 --> 00:47:34,310
+هيك تيوبة الـ Waste تاخديها و بترميها، discard،
+
+535
+00:47:34,310 --> 00:47:39,940
+نرميها، لأن كلها Waste، فضلات، RBCs اتكسرتهالجيتب
+
+536
+00:47:39,940 --> 00:47:43,640
+تاخد الـ Column أصبح فيه في الـ Column الـ Reason
+
+537
+00:47:43,640 --> 00:47:49,100
+حامل فقط الـ Hemoglobins بتروح تجيب تيوب نظيفة
+
+538
+00:47:49,100 --> 00:47:54,540
+Plastic تيوب نظيفة وبتكتبي عليها Hemoglobin A1C
+
+539
+00:47:54,540 --> 00:47:58,740
+الشغل اللي أنا بدي أجيسها وبحط ال Column فوق الـ
+
+540
+00:47:58,740 --> 00:48:05,720
+Plastic تيوب رقم أربعةبروح أضيف أربع ML يعني أربع
+
+541
+00:48:05,720 --> 00:48:11,640
+تلاف مايكرو ليتر من Reagent رقم تلاتة Reagent رقم
+
+542
+00:48:11,640 --> 00:48:16,400
+تلاتة هيعمل اليوشن يعني هالجيت صارت كل ال
+
+543
+00:48:16,400 --> 00:48:19,960
+Hemoglobins موجودة في الرزن أنا بثبت Hemoglobin
+
+544
+00:48:19,960 --> 00:48:25,340
+A1Cلمّا بضيف Reagent 3 على الـ Column Reagent 3
+
+545
+00:48:25,340 --> 00:48:31,620
+هيفق الـ Hemoglobin A1C عن الرزن وينزل Hemoglobin
+
+546
+00:48:31,620 --> 00:48:37,540
+A1C في الـ Plastic A-Tube اللي نزل التخضيه وبتروح
+
+547
+00:48:37,540 --> 00:48:41,200
+على الـ Spectrophotometer بتسفر على مياه،
+
+548
+00:48:41,200 --> 00:48:45,840
+Distilled Water وبعدين بتحطي المحلول اللي نزلفي
+
+549
+00:48:45,840 --> 00:48:49,360
+الكيوفيت وبتقرا E على الـ Spectrophotometer على
+
+550
+00:48:49,360 --> 00:48:55,160
+415 نانومتر إذاً هيك احنا صار عندنا الـ Absorbance
+
+551
+00:48:55,160 --> 00:49:01,160
+لهيموجلبن A1C بيحكي للفحص بيضلوا stable على الأقل
+
+552
+00:49:01,160 --> 00:49:06,240
+ساعة كاملة يعني خلال ساعة وجدت ما تعمل الفحص معاك
+
+553
+00:49:06,240 --> 00:49:12,050
+ساعة انك تعمل الفحص النتائج بتضلها ثابتةبعدين في
+
+554
+00:49:12,050 --> 00:49:16,830
+شغل لازم نعملها اعملتوها في Hemoglobin A2 أذكركم
+
+555
+00:49:16,830 --> 00:49:21,850
+بروح أجيب Plastic Tube نظيفة و بكتب عليها Total
+
+556
+00:49:21,850 --> 00:49:28,070
+Hemoglobins بدنا نفحص أو بدنا نشوف نجيب الـ
+
+557
+00:49:28,070 --> 00:49:32,090
+Absorbance للـ Total Hemoglobins كلها اللي موجودة
+
+558
+00:49:32,090 --> 00:49:36,950
+جوات الـ RBCs فبنروح نجيب Plastic Tube و بنسميها
+
+559
+00:49:36,950 --> 00:49:43,320
+Total Hemoglobins هذه الـ Tube إيش بنحط فيها؟بنحط
+
+560
+00:49:43,320 --> 00:49:52,020
+فيها 6 ML من الـ Reagent 3 و 25 ميكروليتر من الـ
+
+561
+00:49:52,020 --> 00:49:56,080
+Hemolysate الـ Hemolysate اللي حضرناه في أول مرة
+
+562
+00:49:56,080 --> 00:49:59,640
+في الـ slide الأولى الـ Hemolysate اللي بيحتوي على
+
+563
+00:49:59,640 --> 00:50:04,300
+الـ Hemoglobins كلها والـ RBCs اللي اتكسرتطبعاً
+
+564
+00:50:04,300 --> 00:50:09,680
+انتوا هنا حاطيتلكم 12ML و 50 مايكرون كميات كبيرة
+
+565
+00:50:09,680 --> 00:50:15,200
+فعليا لما نيجي نشتغل عملي هناخد نص الكمية 6ML و 25
+
+566
+00:50:15,200 --> 00:50:20,150
+مايكرون برضه بصفر ع الـ distilled waterوهذا الـ
+
+567
+00:50:20,150 --> 00:50:25,210
+mix الـ 6 مل والـ 25 ميكروليتر تاخديه وبتسافري ع
+
+568
+00:50:25,210 --> 00:50:28,290
+الـ distilled water وبرضه بتقرأ ايه بتحطيه في الـ
+
+569
+00:50:28,290 --> 00:50:33,570
+cuvette و بتقرأ ايه على 415 نانومتر إذاً هيك انت
+
+570
+00:50:33,570 --> 00:50:37,950
+بتجيب الـ absorbance لمن؟ للـ total hemoglobins
+
+571
+00:50:37,950 --> 00:50:43,350
+لأن هذا الخطوة هتفيدنا في القانون لما بدي أجي أحسب
+
+572
+00:50:43,350 --> 00:50:49,360
+نسبة مخزون السكر لازم يكون عندهالـ Total
+
+573
+00:50:49,360 --> 00:50:52,300
+Hemoglobin الـ Absorbance للـ Total Hemoglobin
+
+574
+00:50:52,300 --> 00:50:57,040
+انشوف ال calculations الحسابات
+
+575
+00:50:58,630 --> 00:51:03,950
+الـ Hemoglobin A1C بتم التعبير عنه بنسبة مئوية هيك
+
+576
+00:51:03,950 --> 00:51:07,990
+الـ Range تبعه مش بـ Concentration مش بتركيز إنما
+
+577
+00:51:07,990 --> 00:51:13,470
+بنسبة مئوية النسبة المئوية لهيمoglobin A1C تساوي
+
+578
+00:51:13,470 --> 00:51:19,010
+هيك القانون الـ Absorbance لهيمoglobin A1C جيبناه
+
+579
+00:51:19,010 --> 00:51:24,050
+ولا ما جيبناه؟ جيبناهدرب الـ Volume لـ Hemoglobin
+
+580
+00:51:24,050 --> 00:51:32,150
+A1C يقصد أي Volume؟ يقصد حجم الـ Reagent اللي
+
+581
+00:51:32,150 --> 00:51:37,250
+استخدم عشان يعمل اليوشن لـ Hemoglobin A1C لو
+
+582
+00:51:37,250 --> 00:51:42,210
+رجعتوا للـ slide اللي جابلها جداش أنا ضفت من
+
+583
+00:51:42,210 --> 00:51:49,470
+Reagent تلاتةعشان يفك الـ Hemoglobin A1C أضفت 4 ML
+
+584
+00:51:49,470 --> 00:51:55,030
+إذا لما يحكيلي حجم الـ Volume تبع Hemoglobin A1C
+
+585
+00:51:55,030 --> 00:51:58,910
+جزده حجم الـ Reagent، الكمية تحت الـ Reagent اللي
+
+586
+00:51:58,910 --> 00:52:02,850
+أنا ضفتها عشان يعملي Illusion لـ Hemoglobin A1C
+
+587
+00:52:02,850 --> 00:52:07,930
+يعني ضرب 4 الـ Absorbers اللي جبته من الجهاز لـ
+
+588
+00:52:07,930 --> 00:52:14,550
+Hemoglobin A1C ضرب 4 علىالـ Absorbance للـ Total
+
+589
+00:52:14,550 --> 00:52:18,930
+Hemoglobin هذي الـ Tube اللي احنا قرأناها على الـ
+
+590
+00:52:18,930 --> 00:52:22,130
+Spectrophotometer وحضرناها في الـ Slide فوق، اذا
+
+591
+00:52:22,130 --> 00:52:27,810
+انتبهتوا، 6ML مع 25 Micron وقرأناها على الجهاز،
+
+592
+00:52:27,810 --> 00:52:33,680
+ضرب الـ Volumeلـ Total Hemoglobin برضه كمية الـ
+
+593
+00:52:33,680 --> 00:52:39,240
+Reagent اللي أنا أضفتها على الـ Hemolysate جدسه
+
+594
+00:52:39,240 --> 00:52:44,600
+أضفت 6 ML صح ولا لأ؟ يعني ضرب 6 الـ Absorbance لـ
+
+595
+00:52:44,600 --> 00:52:49,320
+Total Hemoglobin ضرب 6 كل هذا ضرب 100% بيطلع عند
+
+596
+00:52:49,320 --> 00:52:53,880
+مخزون السكر يا جماعة بدي أحكيلكم هذه طريقة الـ
+
+597
+00:52:53,880 --> 00:53:00,280
+Cation Exchange Chromatography طريقة Manualعلى ما
+
+598
+00:53:00,280 --> 00:53:06,760
+أعتقد ما ضال حدا بيستخدمها يعني قليل مختبرات ممكن
+
+599
+00:53:06,760 --> 00:53:13,020
+نلاجيها موجودة بس هي الأصل هالجيط أصبح فينا أجهزة
+
+600
+00:53:13,740 --> 00:53:17,920
+انتي ما عليكي فقط غير تاخدي عينة الـHoly Blood
+
+601
+00:53:17,920 --> 00:53:22,920
+اللي جمعتيها في الـEdita واتحطيها في جهاز وخلال
+
+602
+00:53:22,920 --> 00:53:28,260
+دقائق الجهاز بيطلع جديش نسبة مخزون السكر عند هذا
+
+603
+00:53:28,260 --> 00:53:32,240
+المريض، تمام؟ إذا أصبح اليوم في المستشفيات وفي
+
+604
+00:53:32,240 --> 00:53:36,500
+المختبرات نظام جهاز بيطلع مخزون السكر عالسريع من
+
+605
+00:53:36,500 --> 00:53:39,920
+غير هذا الشغل اللي احنا بنشتغله شغل الـManual،
+
+606
+00:53:39,920 --> 00:53:44,710
+تمام؟الـ Reference Range «Glycated Hemoglobin» أو
+
+607
+00:53:44,710 --> 00:53:48,450
+«Hemoglobin A1C» is expressed as a percentage
+
+608
+00:53:48,450 --> 00:53:52,430
+حكينا إن مخزون السكر نتيجته بنطلعها بالنسبة
+
+609
+00:53:52,430 --> 00:53:57,670
+المئوية الإنسان الطبيعي اللي ما عنده سكري لازم
+
+610
+00:53:57,670 --> 00:54:04,620
+يطلع مخزون السكر عنده أجل من 6.4%أما إنسان مريض
+
+611
+00:54:04,620 --> 00:54:09,080
+سكري يعني «Diabetes Mellitus» عنده مرض السكري لكن
+
+612
+00:54:09,080 --> 00:54:14,720
+بيعمل حمية غذائية بياكل أكل صحي، بلعب exercise
+
+613
+00:54:14,720 --> 00:54:20,800
+بياخد جرعات الإنسولين بالشكل الصحيح يعني عامل
+
+614
+00:54:20,800 --> 00:54:25,400
+«Good Control» محافظ على نفسه هذا الشخص بيطلع عنده
+
+615
+00:54:25,400 --> 00:54:34,160
+مخزون السكر من 6.5% لـ 8.4%لكن إنسان عنده diabetes
+
+616
+00:54:34,160 --> 00:54:38,500
+mellitus عنده مرض السكري لكن بيخبص كتير في الأكل
+
+617
+00:54:38,500 --> 00:54:42,900
+ما بيلعب exercise ما بياخد جرعات الإنسولين بالشكل
+
+618
+00:54:42,900 --> 00:54:48,600
+الصحيح معناه هو not control مش عامل سيطرة على نفسه
+
+619
+00:54:48,600 --> 00:54:54,660
+فمخزون السكر عادة بيطلع عنده عالي كتير أعلى من 8.5
+
+620
+00:54:54,660 --> 00:54:56,160
+% تمام؟
+
+621
+00:54:58,390 --> 00:55:02,650
+Interpretation of Glycated HemoglobinGlycated
+
+622
+00:55:02,650 --> 00:55:06,430
+Hemoglobin should be routinely monitored at least
+
+623
+00:55:06,430 --> 00:55:10,330
+every 3 months in all insulin-treated patients
+
+624
+00:55:10,330 --> 00:55:16,130
+مخزون السكر يفترض بشكل روتين على الأقل كل 3 شهور
+
+625
+00:55:16,130 --> 00:55:22,930
+لناس اللي عندها سكر وبتاخد الإنسلين كعلاج انتبعها
+
+626
+00:55:22,930 --> 00:55:29,200
+من خلال فحص الـ Hemoglobin A1Cعندي causes of
+
+627
+00:55:29,200 --> 00:55:35,940
+elevated hemoglobin A1C أسباب تؤدي إلى زيادة مخزون
+
+628
+00:55:35,940 --> 00:55:40,040
+السكر أول سبب هذا موضوعنا الـ uncontrolled
+
+629
+00:55:40,040 --> 00:55:44,600
+diabetes mellitus مريض السكري اللي مش عامل control
+
+630
+00:55:44,600 --> 00:55:49,300
+على نفسه مش محافظ على أكله مابلعب exercise مابياخد
+
+631
+00:55:49,300 --> 00:55:57,330
+جريعات الإنسلينبالشكل الصحيح هذا الشخص عنده سكر
+
+632
+00:55:57,330 --> 00:56:02,070
+كتير في الدم بالتالي هتفوت كميات سكر كبيرة لخلايا
+
+633
+00:56:02,070 --> 00:56:06,910
+الـ RBCs عشان ترتبط بـ Hemoglobin A1 وتكون
+
+634
+00:56:06,910 --> 00:56:12,430
+Hemoglobin A1C بكميات أكبرإذن الـ Uncontrolled
+
+635
+00:56:12,430 --> 00:56:18,510
+diabetes mellitus يؤدي إلى زيادة مخزون السكر أيضًا
+
+636
+00:56:18,510 --> 00:56:23,670
+الارتفاع في Hemoglobin F الزيادة في الـ
+
+637
+00:56:23,670 --> 00:56:28,100
+Triglycerides الدهون التلاتيةالـ Lead toxicity
+
+638
+00:56:28,100 --> 00:56:32,740
+التسمم الرصاص الناس اللي بيعملوا Hemodialysis
+
+639
+00:56:32,740 --> 00:56:36,660
+واللي عندهم Renal Failure فشل كلوي أو Hemodialysis
+
+640
+00:56:36,660 --> 00:56:43,200
+غثيل كلا كل هذه الحالات تسبب ارتفاع في مخزون السكر
+
+641
+00:56:43,200 --> 00:56:48,040
+احنا موضوعنا في الـ Uncontrolled Diabetes Mellitus
+
+642
+00:56:48,600 --> 00:56:52,200
+وارفنا كيف الميكانيزم، باجي الأسباب مش مهم أعرف
+
+643
+00:56:52,200 --> 00:56:57,060
+الميكانيزم أهم إشي إن الشخص اللي سكره عالي في الدم
+
+644
+00:56:57,910 --> 00:57:03,290
+أكيد مخزون السكر برضه هيطلع عنده عالي «causes of
+
+645
+00:57:03,290 --> 00:57:09,210
+decreased hemoglobin A1C» أسباب تؤدي إلى النقص في
+
+646
+00:57:09,210 --> 00:57:14,790
+مخزون السكر «causes of decreased RBC lifespan» كل
+
+647
+00:57:14,790 --> 00:57:20,280
+الأسباب اللي بيصير فيها عمر الـ RBC بتقصرزي ما
+
+648
+00:57:20,280 --> 00:57:24,280
+حكيتلكوا الـ Hemolytic Anemia و الـ bleeding حالات
+
+649
+00:57:24,280 --> 00:57:28,580
+النظيف اللي بتنفيها فقد أصلا ال RBCs فقد الدم
+
+650
+00:57:28,580 --> 00:57:33,400
+معناه السكر مش هيكون له فرصة ان ييجي جوا ال RBCs
+
+651
+00:57:33,400 --> 00:57:37,120
+يدخل عشان يرتبط بي ال Hemoglobin و يكون Hemoglobin
+
+652
+00:57:37,120 --> 00:57:42,160
+A1C كذلك Hemolytic Anemia يعني عمر ال RBC قصير جدا
+
+653
+00:57:42,160 --> 00:57:49,360
+تتكون ال RBCsبتتكسر بسرعة، معناه مافي فرصة انه هذه
+
+654
+00:57:49,360 --> 00:57:54,140
+الـRBCs تظلها زي ما هي ويدخل جواها السكر لأنها
+
+655
+00:57:54,140 --> 00:57:57,940
+عمرها قصير، بتتكسر بسرعة، بيصيرلها الـdegradation
+
+656
+00:57:57,940 --> 00:58:04,220
+فما بيلحق السكر يفوت جوات الـRBCs ويكون Hemoglobin
+
+657
+00:58:04,220 --> 00:58:07,700
+A1C وبالتالي تركيزه هيقل أيضا في حالات
+
+658
+00:58:07,700 --> 00:58:13,070
+الـHemodilution وخاصة عند النساء الحواملأهم إشي
+
+659
+00:58:13,070 --> 00:58:17,150
+بدنا نعرف شغلتان الـ uncontrolled diabetes
+
+660
+00:58:17,150 --> 00:58:23,030
+mellitus سبب من الأسباب الأساسية في إن مخزون السكر
+
+661
+00:58:23,030 --> 00:58:27,250
+يكون عالي اللي هم مرضى السكري اللي ما بيحافظوا على
+
+662
+00:58:27,250 --> 00:58:30,890
+حالهم تمام؟ ياتيكل عافية
+
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/8z-8bV0QAco.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/8z-8bV0QAco.srt
new file mode 100644
index 0000000000000000000000000000000000000000..4d2fda32f5c8ee7752faec22920ab89d6e2f4565
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/8z-8bV0QAco.srt
@@ -0,0 +1,1534 @@
+1
+00:00:01,030 --> 00:00:04,290
+السلام عليكم ورحمة الله وبركاته يعطيكم العافية
+
+2
+00:00:04,290 --> 00:00:08,030
+جميعًا إن شاء الله اليوم محاضرتنا بعنوان Bilirubin
+
+3
+00:00:08,030 --> 00:00:09,270
+Test
+
+4
+00:00:11,590 --> 00:00:15,170
+One of the most important liver functions is
+
+5
+00:00:15,170 --> 00:00:18,930
+one that is involved in a large number of diseases
+
+6
+00:00:18,930 --> 00:00:24,910
+is the excretion of bile. بيحكيلي واحدة من أهم
+
+7
+00:00:24,910 --> 00:00:29,530
+الوظائف اللي بيشتغل فيها الكبد ويمكن حكيناها
+
+8
+00:00:29,530 --> 00:00:33,370
+في المحاضرة اللي فاتت أنه مسئول عن تصنيع الأحماض الصفراوية
+
+9
+00:00:33,370 --> 00:00:38,550
+العصارة الصفراوية، والعصارة الصفراوية حكينا بتساعد
+
+10
+00:00:38,550 --> 00:00:43,770
+الكبد بعد ما يكونها بعمل لها excretion بيوديها
+
+11
+00:00:43,770 --> 00:00:49,470
+وبتنتقل عبر القناة الصفراوية للأمعاء عشان هناك الـ
+
+12
+00:00:49,470 --> 00:00:55,610
+bile acids بتساعد في هضم الدهون، تمام؟ فواحدة من
+
+13
+00:00:55,610 --> 00:01:02,310
+وظائف الكبد المهمة إنه بعمل excretion للأحماض
+
+14
+00:01:02,310 --> 00:01:07,190
+الصفراوية، وبتمشي عبر قناة اسمها
+
+15
+00:01:07,190 --> 00:01:11,730
+الـ biliary duct اللي هي قناة العصارة الصفراوية
+
+16
+00:01:11,730 --> 00:01:15,950
+بتمشي من الكبد وبتروح على الأمعاء عشان تساعد في
+
+17
+00:01:15,950 --> 00:01:21,450
+هضم الدهون أيضًا. الـ excretion of bile خروج هذه
+
+18
+00:01:21,450 --> 00:01:25,990
+العصارة من الكبد ممكن يصير فيه أحيانًا problem
+
+19
+00:01:25,990 --> 00:01:30,430
+ويصير فيه مشكلة في عملية الـ excretion لهذه
+
+20
+00:01:30,430 --> 00:01:37,390
+العصارة الصفراوية، تمام؟ Bile comprises bile acids or
+
+21
+00:01:37,390 --> 00:01:41,830
+salts. بيحكيلي إنه العصارة الصفراوية يا بيسموها bile
+
+22
+00:01:41,830 --> 00:01:46,890
+acids أو bile salts عبارة عن شو؟ بتتكون من شو هذه الـ
+
+23
+00:01:46,890 --> 00:01:50,610
+bile acids و الـ bile salts عبارة عن bile pigments
+
+24
+00:01:50,610 --> 00:01:55,110
+and others. يعني هي عصارة صفراوية ومن اسمها صفراوية
+
+25
+00:01:55,110 --> 00:02:00,590
+يعني في مادة كيميائية تعطيها اللون الأصفر تعطيها
+
+26
+00:02:00,590 --> 00:02:05,760
+العصارة الصفراوية اللون الأصفر، تمام؟ هنشوف شو هي
+
+27
+00:02:05,760 --> 00:02:10,320
+المادة.  Bilirubin is the principal pigment in the
+
+28
+00:02:10,320 --> 00:02:15,180
+bile. البيلروبين هذه المادة الكيميائية هي اللي
+
+29
+00:02:15,180 --> 00:02:20,620
+بتعطي العصارة الصفراوية اللون الأصفر.
+
+30
+00:02:20,620 --> 00:02:26,700
+تمام؟ Bilirubin is derived from the breakdown of hemoglobin.
+
+31
+00:02:26,700 --> 00:02:30,900
+البيلروبين من وين جاي؟ جاي من تكسير الهيموجلوبين
+
+32
+00:02:30,900 --> 00:02:36,160
+يعني يا جماعة كريات الدم الحمراء عمرها 120 يوم، كل 120
+
+33
+00:02:36,160 --> 00:02:40,180
+يوم كريات الدم الحمراء بتتكسر وبتطلع بدالها، لما بتتكسر
+
+34
+00:02:40,180 --> 00:02:44,600
+كريات الدم الحمراء بتطلع الهيموجلوبين منها، أيضًا الهيموجلوبين
+
+35
+00:02:44,600 --> 00:02:49,060
+هو بروتين له عمر معين، له half-life معين أيضًا
+
+36
+00:02:49,060 --> 00:02:53,770
+بيتكسر. لما بتتكسر الـ Hemoglobin كلكم عارفين،
+
+37
+00:02:53,770 --> 00:02:58,330
+بعطيني الـ heme group، الـ heme group و الـ globin
+
+38
+00:02:58,330 --> 00:03:04,390
+group. أيضًا الـ heme group لما يتكسّر، حاصل تكسير
+
+39
+00:03:04,390 --> 00:03:09,050
+الـ heme group تتكون عندي مادة البيلروبين، يعني لو
+
+40
+00:03:09,050 --> 00:03:13,190
+سألناكم، المادة الكيميائية البيلروبين من وين
+
+41
+00:03:13,190 --> 00:03:17,510
+جاية؟ جاية من تكسير الـ heme اللي موجود في الـ
+
+42
+00:03:17,510 --> 00:03:21,360
+Hemoglobin. بس إحنا تجاوزًا، عالسريع بنحكي جاية من
+
+43
+00:03:21,360 --> 00:03:25,780
+تكسير الهيموجلوبين، تمام؟ إذًا في هذه الـ slide
+
+44
+00:03:25,780 --> 00:03:29,540
+يعني معلومات عامة، بس أنا بدي أركز إن البيلروبين
+
+45
+00:03:29,540 --> 00:03:33,800
+جاي من تكسير الهيموجلوبين اللي موجود في
+
+46
+00:03:33,800 --> 00:03:38,440
+كريات الدم الحمراء، وتكسير بالضبط إيش الـ heme group، تمام؟
+
+47
+00:03:41,770 --> 00:03:48,390
+بيلروبين، هناك نوعين من البيلروبين من هذه المادة
+
+48
+00:03:48,390 --> 00:03:52,150
+الكيميائية، النوع الأول بيسموه conjugated أو
+
+49
+00:03:52,150 --> 00:03:57,590
+indirect bilirubin، البيلروبين المرتبط، أما النوع
+
+50
+00:03:57,590 --> 00:04:02,030
+الآخر هو الـ unconjugated bilirubin أو بيسموه
+
+51
+00:04:02,030 --> 00:04:08,180
+indirect bilirubin، هو البيلروبين الغير مرتبط. Total
+
+52
+00:04:08,180 --> 00:04:12,040
+bilirubin is composed of the conjugated bilirubin
+
+53
+00:04:12,040 --> 00:04:15,760
+plus the unconjugated bilirubin. يعني لما أحكيلك
+
+54
+00:04:15,760 --> 00:04:20,340
+اعمليلي فحص الـ total bilirubin في الدم، يعني بدك
+
+55
+00:04:20,340 --> 00:04:24,820
+تحسبي الـ unconjugated bilirubin، البيلروبين الغير
+
+56
+00:04:24,820 --> 00:04:30,080
+مرتبط، زائد الـ conjugated bilirubin، البيلروبين
+
+57
+00:04:30,080 --> 00:04:35,140
+المرتبط، تجمعيهم مع بعض بتطلع لك الـ total bilirubin
+
+58
+00:04:35,140 --> 00:04:41,860
+ككل، تمام؟ يعني شو الفرق بين النوعين؟ والنوعين
+
+59
+00:04:41,860 --> 00:04:48,160
+بيكونوا موجودين في بلازما الدم، النوع المرتبط
+
+60
+00:04:48,160 --> 00:04:54,980
+والنوع الغير مرتبط. يعني لو جينا مع بعض نشوف كل
+
+61
+00:04:54,980 --> 00:04:58,780
+نوع وين بيجي؟ يعني يا جماعة كلكم عارفين إن
+
+62
+00:04:58,780 --> 00:05:05,220
+كريات الدم الحمراء عمرها 120 يوم، وبعد 120 يوم بتتكسر، لما
+
+63
+00:05:05,220 --> 00:05:09,140
+بتتكسر كريات الدم الحمراء بتطلع منها الهيموجلوبين، أيضًا
+
+64
+00:05:09,140 --> 00:05:13,660
+الهيموجلوبين بيتكسر، حاصل تكسير الهيموجلوبين
+
+65
+00:05:13,660 --> 00:05:18,280
+بعطيني بيلروبين. طيب هذا البيلروبين إيش نوعه
+
+66
+00:05:18,280 --> 00:05:22,670
+اللي جاي من تكسير الهيموجلوبين؟ نوعه unconjugated
+
+67
+00:05:22,670 --> 00:05:26,830
+bilirubin، بيلروبين غير مرتبط، يعني لو سألناكم
+
+68
+00:05:26,830 --> 00:05:31,450
+سؤال، شو نوع البيلروبين اللي جاي من تكسير الـ
+
+69
+00:05:31,450 --> 00:05:37,480
+Hemoglobin واللي بالأخص جاي من تكسير الـ heme group
+
+70
+00:05:37,480 --> 00:05:41,840
+اللي موجودة في الهيموجلوبين، هتحكوا لي نوعه بيلروبين
+
+71
+00:05:41,840 --> 00:05:46,520
+غير مرتبط، unconjugated bilirubin. يعني لما
+
+72
+00:05:46,520 --> 00:05:50,820
+اتكسرت كريات الدم الحمراء واتكسر الهيموجلوبين وطلع الـ
+
+73
+00:05:50,820 --> 00:05:54,740
+unconjugated bilirubin على الدم، هذا الـ
+
+74
+00:05:54,740 --> 00:05:58,100
+unconjugated bilirubin، البيلروبين غير المرتبط، هذا
+
+75
+00:05:58,100 --> 00:06:02,900
+خطير جدًا، ممنوع يظل في الدم، زي زي الأمونيا، إذا
+
+76
+00:06:02,900 --> 00:06:07,420
+بتتذكروا المحاضرة اللي فاتت، تمام؟ فمادة الأمونيا سامة،
+
+77
+00:06:07,420 --> 00:06:12,880
+أيضًا مادة الـ unconjugated bilirubin سامة، ليش؟ لأن
+
+78
+00:06:12,880 --> 00:06:17,820
+هذه المادة ممكن تخترق غشاء الدماغ وتفوت على الدماغ
+
+79
+00:06:17,820 --> 00:06:22,110
+وتعمل مشاكل وممكن تؤدي إلى الوفاة. لو ارتفع الـ
+
+80
+00:06:22,110 --> 00:06:26,210
+unconjugated bilirubin في الدم، عشان هيك يا جماعة
+
+81
+00:06:27,060 --> 00:06:31,320
+الـ unconjugated bilirubin موجود في بلازما الدم
+
+82
+00:06:31,320 --> 00:06:36,520
+ولكن بتركيز قليل جدًا، تمام؟ At very very low
+
+83
+00:06:36,520 --> 00:06:41,400
+concentration. طيب كيف الجسم بيتخلص؟ بما أنه سام
+
+84
+00:06:41,400 --> 00:06:45,660
+للدم وسام للدماغ، يفترض الجسم يتخلص منه، هذا الـ
+
+85
+00:06:45,660 --> 00:06:50,440
+unconjugated bilirubin. طيب كيف الجسم بيتخلص منه؟
+
+86
+00:06:50,440 --> 00:06:57,100
+بيروح على الكبد، وفي الكبد يتم التخلص من الـ
+
+87
+00:06:57,100 --> 00:07:01,740
+unconjugated bilirubin. هو بيظل جزء منه موجود في
+
+88
+00:07:01,740 --> 00:07:08,080
+بلازما الدم، ولكن بتركيز قليل جدًا، أما الكمية الأكبر
+
+89
+00:07:08,080 --> 00:07:11,920
+لازم الجسم يتخلص منها، ومين بيتخلص من الـ
+
+90
+00:07:11,920 --> 00:07:17,840
+unconjugated bilirubin؟ هو الكبد، تمام؟ تمام، نشوف
+
+91
+00:07:17,840 --> 00:07:21,920
+النقطة الثالثة. Total bilirubin level increases
+
+92
+00:07:21,920 --> 00:07:26,300
+with any type of jaundice. كلنا بنسمع بيه مرض
+
+93
+00:07:26,300 --> 00:07:32,480
+اليرقان، تمام؟ بيكون الشخص وجهه أصفر، ممكن يتطور
+
+94
+00:07:32,480 --> 00:07:37,000
+الوضع، العينين عنده تكون صفراء كثير، المنطقة البيضاء
+
+95
+00:07:37,000 --> 00:07:40,800
+اللي في العين بتكون صفراء كثير، هذا بيسموه يرقان، لما
+
+96
+00:07:40,800 --> 00:07:45,760
+الإنسان نحكي عنده يرقان، معناه لو فحصت له الـ total
+
+97
+00:07:45,760 --> 00:07:52,560
+بيلروبين عنده هيكون عالي كثير، تمام؟ هنوضح هذه
+
+98
+00:07:52,560 --> 00:07:56,740
+الجملة في الفقرات الثانية أو في الـ slides الثانية
+
+99
+00:07:56,740 --> 00:08:03,080
+تمام؟ الـ metabolism of bilirubin، نشوف بالضبط كيف
+
+100
+00:08:03,080 --> 00:08:07,580
+الـ bilirubin بتتكون، وأين بيروح، وكيف الجسم
+
+101
+00:08:07,580 --> 00:08:14,700
+بيتخلص منه، لأنه مادة سامة، تمام؟ أول شيء حكينا إنه
+
+102
+00:08:14,700 --> 00:08:19,360
+تابعوا معايا على الـ chart فوق، في المربع هذا
+
+103
+00:08:19,360 --> 00:08:23,080
+المكان، في الـ reticuloendothelial system، في
+
+104
+00:08:23,080 --> 00:08:29,260
+الأماكن اللي بيصير فيها تكسير لكريات الدم الحمراء، لما بيخلص
+
+105
+00:08:29,260 --> 00:08:34,980
+عمرها، إذا اتفقنا إن كريات الدم الحمراء عمرها 120 يوم، لما
+
+106
+00:08:34,980 --> 00:08:40,040
+بتخلص عمرها بتتكسر، بيصير release للهيموجلوبين،
+
+107
+00:08:40,040 --> 00:08:44,160
+بيطلع الهيموجلوبين منها، الهيموجلوبين أيضًا بيتكسر
+
+108
+00:08:44,160 --> 00:08:49,960
+لهيم و globin.  الـ heme حكينا برضه بيتكسر، الـ heme
+
+109
+00:08:49,960 --> 00:08:56,080
+اللي بيتكسر، نتيجة تكسير الـ heme تتكون عندي مادة الـ
+
+110
+00:08:56,080 --> 00:09:00,960
+unconjugated bilirubin، البيلروبين الغير مرتبط.
+
+111
+00:09:01,910 --> 00:09:06,330
+يعني بعد ما يتكون أو يطلع الـ unconjugated
+
+112
+00:09:06,330 --> 00:09:12,090
+bilirubin من الهيم، من حاصل تكسير الهيم، بيروح على
+
+113
+00:09:12,090 --> 00:09:17,410
+بلازما الدم. اتفقنا إنه في البلازما ممنوع
+
+114
+00:09:17,410 --> 00:09:21,670
+الـ unconjugated bilirubin يكون بتركيز عالي، لأن
+
+115
+00:09:21,670 --> 00:09:26,410
+مادة سامة، ممكن تخترق غشاء الدماغ، وبتؤدي إلى
+
+116
+00:09:26,410 --> 00:09:31,600
+الوفاة. وجوده، فهو موجود في بلازما الدم في الوضع
+
+117
+00:09:31,600 --> 00:09:35,980
+الطبيعي at very low concentration، بتركيز قليل جدًا
+
+118
+00:09:35,980 --> 00:09:42,000
+عشان هيك الجسم بده يتخلص من الـ unconjugated
+
+119
+00:09:42,000 --> 00:09:46,930
+bilirubin. كيف؟ للأسف الـ unconjugated bilirubin هذا
+
+120
+00:09:46,930 --> 00:09:51,110
+زي زي الدهون، insoluble في بلازما الدم، ما بقدرش
+
+121
+00:09:51,110 --> 00:09:55,390
+يمشي، غير دائمًا في بلازما الدم، ما بقدرش يمشي في
+
+122
+00:09:55,390 --> 00:10:00,440
+البلازما لحاله، بده carrier، بده ناقل، بيجي عند الـ
+
+123
+00:10:00,440 --> 00:10:05,260
+albumin، عبارة عن بروتين ناقل للـ unconjugated
+
+124
+00:10:05,260 --> 00:10:10,040
+bilirubin، بيحمل الـ unconjugated bilirubin من الـ
+
+125
+00:10:10,040 --> 00:10:14,100
+plasma، الدم إلى الـ liver، إلى الكبد. تابعوا على الـ
+
+126
+00:10:14,100 --> 00:10:19,000
+chart خطوة خطوة، تمام؟ إذًا الـ unconjugated
+
+127
+00:10:19,000 --> 00:10:24,000
+bilirubin معظمُه وصل للـ liver، وظل تركيز قليل منه
+
+128
+00:10:24,000 --> 00:10:28,600
+موجود في بلازما الدم، وهذا الوضع الطبيعي. يعني في
+
+129
+00:10:28,600 --> 00:10:34,420
+الكبد، الـ unconjugated bilirubin لازم أحوله لمادة
+
+130
+00:10:34,420 --> 00:10:39,620
+يعني تكون أقل سمية منه، الـ unconjugated bilirubin
+
+131
+00:10:39,620 --> 00:10:46,420
+بدّه يتحول في الكبد لمادة أخرى، هذه المادة الأخرى أقل
+
+132
+00:10:46,420 --> 00:10:50,080
+سمية من الـ unconjugated bilirubin، وبعد ذلك هذه
+
+133
+00:10:50,080 --> 00:10:55,340
+المادة الجسم بيقدر يتخلص منها بكل سهولة. ففي
+
+134
+00:10:55,340 --> 00:10:59,320
+الكبد يوجد هناك إنزيم، مش بالضرورة نعرف اسمه، هتاخذوه
+
+135
+00:10:59,320 --> 00:11:04,820
+في المنهج مع الدكتور مازن. هذا الـ enzyme إيش بيعمل؟
+
+136
+00:11:04,820 --> 00:11:09,960
+بيروح يربط الـ unconjugated bilirubin بمادة اسمها
+
+137
+00:11:09,960 --> 00:11:14,260
+الـ glucuronic acid. ارتباط الـ unconjugated
+
+138
+00:11:14,260 --> 00:11:20,300
+bilirubin بمادة الـ glucuronic acid هيعطيني مركب
+
+139
+00:11:20,300 --> 00:11:25,360
+بسمّوه conjugated bilirubin، البيلروبين المرتبط.
+
+140
+00:11:25,360 --> 00:11:30,300
+ليش حكيت عنه bilirubin مرتبط؟ لأنه عبارة عن الـ
+
+141
+00:11:30,300 --> 00:11:33,960
+unconjugated bilirubin، البيلروبين غير مرتبط
+
+142
+00:11:33,960 --> 00:11:39,800
+رُبط في مادة اسمها glucuronic acid، فطلع عندي مركب
+
+143
+00:11:39,800 --> 00:11:46,900
+اسمه bilirubin-diglucuronide. هذا هو الـ conjugated
+
+144
+00:11:46,900 --> 00:11:50,420
+bilirubin، هو البيلروبين المرتبط، رُبط في
+
+145
+00:11:50,420 --> 00:11:55,860
+glucuronic acid، من ربطه الكبد بواسطة إنزيم موجود
+
+146
+00:11:55,860 --> 00:12:01,210
+فيه، تمام؟ ففي الكبد اتحول الـ unconjugated
+
+147
+00:12:01,210 --> 00:12:06,590
+bilirubin لـ conjugated bilirubin، تمام؟ يعني
+
+148
+00:12:06,590 --> 00:12:12,410
+الكبد هياخد جزء بسيط من هذا الـ conjugated
+
+149
+00:12:12,410 --> 00:12:17,930
+bilirubin عبر أوردة وشرايين ويوديه على بلازما
+
+150
+00:12:17,930 --> 00:12:23,310
+الدم. إذًا أصبح في بلازما الدم في عندنا الـ
+
+151
+00:12:23,310 --> 00:12:27,230
+unconjugated bilirubin والـ conjugated bilirubin
+
+152
+00:12:27,230 --> 00:12:31,650
+يعني إنهم موجودين في بلازما الدم وبتراكيز قليلة،
+
+153
+00:12:31,650 --> 00:12:38,080
+هذا الوضع الطبيعي، تمام؟ تمام، طيب الـ conjugated
+
+154
+00:12:38,080 --> 00:12:43,140
+bilirubin حكينا جزء بسيط بواسطة الكبد وشرايينه أو
+
+155
+00:12:43,140 --> 00:12:47,820
+أوردته تم إيصاله لبلازما الدم، طيب الجزء الكبير اللي
+
+156
+00:12:47,820 --> 00:12:51,600
+ضايل، الـ conjugated bilirubin وين بده يروح، الجسم
+
+157
+00:12:51,600 --> 00:12:57,050
+بده يتخلص منه؟ الـ conjugated bilirubin بيروح
+
+158
+00:12:57,050 --> 00:13:04,130
+الكبد، وهو بيعمل excretion بواسطة الـ biliary duct،
+
+159
+00:13:04,130 --> 00:13:09,190
+شايفين؟ هي الكبد، بعد الكبد مكتوب عندكم الـ bile،
+
+160
+00:13:09,190 --> 00:13:14,150
+يعني الـ biliary duct، يعني القناة الصفراوية، هيمشي
+
+161
+00:13:14,150 --> 00:13:20,030
+الـ conjugated bilirubin عبر القناة الصفراوية ويظل
+
+162
+00:13:20,030 --> 00:13:24,490
+ماشي لحد ما يصل لـ small intestine، الأمعاء الدقيقة،
+
+163
+00:13:24,490 --> 00:13:28,430
+تمام؟ هذه عندكم الأمعاء الدقيقة، وهي الـ conjugated
+
+164
+00:13:28,430 --> 00:13:35,520
+bilirubin واصل عندها، تمام؟ يعني في الأمعاء الدقيقة
+
+165
+00:13:35,520 --> 00:13:42,200
+في عندنا بكتيريا الـ normal flora، هتحول المادة الـ
+
+166
+00:13:42,200 --> 00:13:47,460
+conjugated bilirubin لمادة اسمها الـ urobilinogen،
+
+167
+00:13:47,460 --> 00:13:53,160
+تمام؟ ممكن سمعتوا فيها، تمام؟ بعدين مادة الـ
+
+168
+00:13:53,160 --> 00:13:57,900
+urobilinogen اللي اتكونت في الأمعاء الدقيقة، هتمشي
+
+169
+00:13:57,900 --> 00:14:04,140
+على الـ large intestine، الأمعاء الغليظة، وهناك برضه
+
+170
+00:14:04,140 --> 00:14:08,240
+هيكون في oxidation، أكسدة، يعني في الأمعاء الغليظة
+
+171
+00:14:08,240 --> 00:14:13,120
+هيتم أكسدة الـ urobilinogen وتحويله لمادة
+
+172
+00:14:13,120 --> 00:14:20,420
+الـ urobilin. بعد هيك المادة الـ urobilin هتطلع مع
+
+173
+00:14:20,420 --> 00:14:26,600
+الـ stool، خارج الجسم، وبهيك الإنسان اتخلص من الـ
+
+174
+00:14:26,600 -->
+
+223
+00:18:05,760 --> 00:18:09,760
+The bilirubin level rises in the blood when obstructive jaundice
+
+224
+00:18:09,760 --> 00:18:14,660
+as from gallstones or hepatic jaundice occurs
+
+225
+00:18:14,660 --> 00:18:20,260
+كلمة or hepatic jaundice occur احذفوها إذا الجملة
+
+226
+00:18:20,260 --> 00:18:24,340
+The bilirubin level rises in the blood when obstructive
+
+227
+00:18:24,340 --> 00:18:27,950
+jaundice as from gallstones في هذه الجملة بيحكينا
+
+228
+00:18:27,950 --> 00:18:32,510
+إن الـ conjugated bilirubin بيزداد تركيزه في الدم
+
+229
+00:18:32,510 --> 00:18:36,710
+في حالة مرضية، في حالة الـ obstructive jaundice
+
+230
+00:18:36,710 --> 00:18:40,430
+إيش يعني obstructive jaundice؟ يعني
+
+231
+00:18:40,430 --> 00:18:44,690
+انسداد بالحصاوي، بالـ gallstones تخيلوا
+
+232
+00:18:44,690 --> 00:18:50,270
+معي أن القناة الصفراوية تحتوي على stones
+
+233
+00:18:50,270 --> 00:18:54,350
+فيها حصاوي  فإن الـ conjugated bilirubin
+
+234
+00:18:54,350 --> 00:18:58,290
+يتكون في الكبد و يجب أن يمر في القناة الصفراوية  ليذهب
+
+235
+00:18:58,290 --> 00:19:02,870
+للأمعاء، تمام؟  في القناة الصفراوية يوجد حصى، يعني ليس
+
+236
+00:19:02,870 --> 00:19:08,230
+بإمكانه المرور، الـ conjugated bilirubin تمام؟ وبالتالي
+
+237
+00:19:08,230 --> 00:19:11,850
+ماذا سيحدث؟ ماذا سيفعل؟  لن يستطيع النزول إلى أسفل و النزول
+
+238
+00:19:11,850 --> 00:19:15,950
+للأمعاء، وبالتالي لن يخرج مع البراز،  سوف يبقى محجوباً
+
+239
+00:19:15,950 --> 00:19:21,290
+فوق في بلازما الدم، سيعود إلى بلازما الدم،  يعود بشكل
+
+240
+00:19:21,290 --> 00:19:26,900
+عكسي إلى بلازما الدم، إذا وجد حصى في القناة
+
+241
+00:19:26,900 --> 00:19:32,540
+الصفرية، فسوف يمنع دخول الـ conjugated bilirubin عبر
+
+242
+00:19:32,540 --> 00:19:36,420
+هذه القناة، فهو يمر عبر هذه القناة  ليصل إلى
+
+243
+00:19:36,420 --> 00:19:40,100
+الأمعاء، وبالتالي لن يستطيع الوصول إلى الأمعاء ولن يخرج
+
+244
+00:19:40,100 --> 00:19:44,780
+خارج الجسم، وبالتالي سيرتفع و يعود إلى بلازما الدم
+
+245
+00:19:44,780 --> 00:19:51,230
+و يزداد تركيزه،  عندما يزداد تركيز الـ conjugated bilirubin
+
+246
+00:19:51,230 --> 00:19:56,350
+يزيد، هذه حالة مرضية،  يُفترض أن يكون تركيزه في
+
+247
+00:19:56,350 --> 00:20:01,010
+البلازما منخفض جداً، ولكن عندما يزداد،  فهذا يعني أن هذه حالة
+
+248
+00:20:01,010 --> 00:20:06,360
+مرضية. In this case, the bilirubin is unable to
+
+249
+00:20:06,360 --> 00:20:09,880
+reach the intestines. في هذه الحالة، الـ bilirubin
+
+250
+00:20:09,880 --> 00:20:14,620
+غير قادر على الوصول إلى الأمعاء ليخرج مع البراز
+
+251
+00:20:14,620 --> 00:20:19,560
+للإخراج. غير قادر، و بدلاً من ذلك يدخل إلى
+
+252
+00:20:19,560 --> 00:20:23,800
+تدفق الدم للإخراج عن طريق الكلى. لذلك
+
+253
+00:20:23,800 --> 00:20:27,320
+ماذا يفعل؟ يذهب،  يعود إلى بلازما الدم،
+
+254
+00:20:27,320 --> 00:20:32,700
+يتراكم في بلازما الدم، ولا يجد حلًا
+
+255
+00:20:32,700 --> 00:20:39,260
+إلا أن يذهب إلى الكلى، والكلى تخرجه مع
+
+256
+00:20:39,260 --> 00:20:44,980
+البول. لذلك، إذا فحصنا الـ conjugated bilirubin في
+
+257
+00:20:44,980 --> 00:20:49,240
+البول، سنجده مرتفع جداً، أعلى بكثير من الإنسان
+
+258
+00:20:49,240 --> 00:20:53,800
+الطبيعي، لماذا؟ لأنه موجود اصلا بتركيز عالي في بلازما الدم
+
+259
+00:20:53,800 --> 00:20:58,060
+وبالتالي سيذهب إلى الكلى، والكلى ماذا
+
+260
+00:20:58,060 --> 00:21:04,100
+ستفعل؟ ستقوم بإخراجه مع البول، وسيزداد
+
+261
+00:21:04,100 --> 00:21:09,830
+تركيزه أكثر في البول.  في بلازما الدم، الـ conjugated
+
+262
+00:21:09,830 --> 00:21:13,790
+bilirubin هو النوع الوحيد من البيليروبين القادر على
+
+263
+00:21:13,790 --> 00:21:17,650
+عبور فلتر الكبيبة.  لذلك، فهو النوع الوحيد
+
+264
+00:21:17,650 --> 00:21:20,770
+من البيليروبين الذي يمكن العثور عليه في البول
+
+265
+00:21:21,840 --> 00:21:25,220
+أما الـ unconjugated bilirubin،  الـ bilirubin
+
+266
+00:21:25,220 --> 00:21:30,360
+غير المرتبط، يخرج من خلايا الدم الحمراء مباشرة، يخرج من تكسير
+
+267
+00:21:30,360 --> 00:21:33,500
+خلايا الدم الحمراء،  يعني من تكسير الهيموغلوبين، ويبقى جزء
+
+268
+00:21:33,500 --> 00:21:37,240
+منه في بلازما الدم، وكلّه يذهب إلى الكبد ويتحول
+
+269
+00:21:37,240 --> 00:21:41,400
+إلى conjugated.  يعني الـ unconjugated bilirubin لا
+
+270
+00:21:41,400 --> 00:21:45,860
+يذهب إلى الكلى ولا يذهب إلى الأمعاء، ولا يخرج مع
+
+271
+00:21:45,860 --> 00:21:50,570
+البول ولا يخرج مع البراز، تمام؟  لكن النوع
+
+272
+00:21:50,570 --> 00:21:55,110
+المرتبط،  الـ bilirubin، الـ conjugated المرتبط، يمر
+
+273
+00:21:55,110 --> 00:21:59,010
+إلى الأمعاء ويخرج مع البراز،  كما يمر على
+
+274
+00:21:59,010 --> 00:22:03,450
+الكلى،  لقد ذكرنا الـ uropilinogen،  جزء منه يذهب إلى
+
+275
+00:22:03,450 --> 00:22:08,070
+الكلى، ويُخرج مع البول، يعني
+
+276
+00:22:08,070 --> 00:22:12,260
+الـ conjugated bilirubin هو النوع الوحيد الذي يمر عبر
+
+277
+00:22:12,260 --> 00:22:18,380
+الكلى،  وتقوم بعملية الترشيح وإخراجه مع
+
+278
+00:22:18,380 --> 00:22:22,620
+البول.  لكن الـ unconjugated لا يمر عبر الكلى ولا
+
+279
+00:22:22,620 --> 00:22:29,060
+الأمعاء،  كلّه يتحول إلى conjugated. أما النوع الآخر
+
+280
+00:22:29,060 --> 00:22:32,940
+الـ unconjugated bilirubin، الـ bilirubin غير
+
+281
+00:22:32,940 --> 00:22:36,620
+المرتبط، أو يُسمى الـ indirect bilirubin أو الـ
+
+282
+00:22:36,620 --> 00:22:39,720
+unconjugated bilirubin، يوجد عادة في
+
+283
+00:22:39,720 --> 00:22:45,480
+تدفق الدم،  فقط أراه في الدم بتركيز منخفض جداً
+
+284
+00:22:45,480 --> 00:22:50,720
+في الحالة الطبيعية.  Unconjugated bilirubin يرتفع في حالة
+
+285
+00:22:50,720 --> 00:22:55,030
+اليرقان الانحلالي. متى يزداد الـ unconjugated
+
+286
+00:22:55,030 --> 00:22:59,540
+bilirubin في حالات فقر الدم الانحلالي؟ ركزوا معي
+
+287
+00:22:59,540 --> 00:23:03,640
+عندما يحدث عندي فقر دم انحلالي،  يعني خلايا الدم الحمراء التي
+
+288
+00:23:03,640 --> 00:23:08,340
+تتكون وتصل إلى الدم بسرعة، تتكسر،  معنى ذلك أن هناك خلايا دم حمراء
+
+289
+00:23:08,340 --> 00:23:12,900
+تتكسر بشكل أكبر، معنى ذلك أن الهيموغلوبين سيحدث له
+
+290
+00:23:12,900 --> 00:23:18,020
+إطلاق، ويتكسر بشكل أكبر،  معنى ذلك أن نتيجة تكسير
+
+291
+00:23:18,020 --> 00:23:22,500
+الهيموغلوبين،  سيخرج unconjugated bilirubin بكميات
+
+292
+00:23:22,500 --> 00:23:27,390
+كبيرة في bloodstream في الدم.  تكسّر
+
+293
+00:23:27,390 --> 00:23:32,110
+الهيموغلوبين ينتج مستوى أعلى من المستوى الطبيعي
+
+294
+00:23:32,110 --> 00:23:36,390
+من unconjugated bilirubin موجود في
+
+295
+00:23:36,390 --> 00:23:40,110
+تدفق الدم.  ما حدث هو أن حالات فقر الدم الانحلالي
+
+296
+00:23:40,110 --> 00:23:46,530
+شديد،  هناك كميات كبيرة من خلايا الدم الحمراء تُنتج
+
+297
+00:23:46,530 --> 00:23:51,720
+وبالتالي كلها تتكسر. أي خلايا دم حمراء تُنتج بسرعة تتكسر
+
+298
+00:23:51,720 --> 00:23:56,040
+لذا يوجد لدي حجم هائل من خلايا الدم الحمراء التي تتكسر وتُنتج
+
+299
+00:23:56,040 --> 00:23:59,880
+الهيموغلوبين،  أيضاً الهيموغلوبين يتكسر ويعطينا
+
+300
+00:23:59,880 --> 00:24:04,340
+unconjugated bilirubin بكميات أكبر من الوضع الطبيعي،
+
+301
+00:24:04,340 --> 00:24:08,100
+تمام؟  إذن الـ unconjugated bilirubin يزيد
+
+302
+00:24:08,100 --> 00:24:12,080
+في حالات فقر الدم الانحلالي، لكن الـ conjugated
+
+303
+00:24:12,080 --> 00:24:16,380
+bilirubin، الـ bilirubin المرتبط،  قلنا يزيد في حالة
+
+304
+00:24:16,750 --> 00:24:22,690
+تكون حصوات في المرارة أو في القناة الصفراوية،
+
+305
+00:24:22,690 --> 00:24:28,280
+تمام؟ This is the type of bilirubin elevated in
+
+306
+00:24:28,280 --> 00:24:32,240
+cases of hepatocellular dysfunction such as
+
+307
+00:24:32,240 --> 00:24:36,540
+hepatitis. الـ unconjugated bilirubin يزيد في حالات
+
+308
+00:24:36,540 --> 00:24:41,600
+فقر الدم الانحلالي، وأيضاً يزيد في حالة حدوث
+
+309
+00:24:41,600 --> 00:24:45,640
+عنده خلل في وظائف الخلايا الكبدية،  مشكلة في خلايا
+
+310
+00:24:45,640 --> 00:24:49,870
+الكبد.  إيش هذه المشكلة؟ مثلًا التهاب الكبد، التهاب الكبد
+
+311
+00:24:49,870 --> 00:24:54,070
+يعني التهاب في خلايا الكبد، بغض النظر عن سبب الالتهاب،
+
+312
+00:24:54,070 --> 00:24:59,450
+فيروس، كحول، أيًا كان، خلايا الكبد حدث فيها مشكلة، حدث
+
+313
+00:24:59,450 --> 00:25:05,730
+فيها تلف، تمام؟ خلايا الدم الحمراء تكسترت وخرج
+
+314
+00:25:05,730 --> 00:25:09,990
+الهيموغلوبين،  الهيموغلوبين تكسر،  وأعطاني
+
+315
+00:25:09,990 --> 00:25:15,570
+unconjugated bilirubin،  ذهب الألبومين حمله ووضعه على
+
+316
+00:25:15,570 --> 00:25:21,720
+الكبد،  الكبد فيه مشكلة، فيه التهاب في خلاياه، تمام؟
+
+317
+00:25:21,720 --> 00:25:27,000
+وبالتالي لن يستطيع الكبد تحويل الـ unconjugated
+
+318
+00:25:27,000 --> 00:25:31,340
+bilirubin إلى conjugated bilirubin، وبالتالي ماذا
+
+319
+00:25:31,340 --> 00:25:34,700
+سيحدث؟ ماذا تتوقعون أن يحدث؟ تتوقعون أن
+
+320
+00:25:34,700 --> 00:25:39,860
+unconjugated bilirubin سيزيد تركيزه في بلازما الدم،
+
+321
+00:25:39,860 --> 00:25:44,910
+لأن الكبد فيه خلل، فيه مشكلة، غير قادر على تحويله، غير قادر
+
+322
+00:25:44,910 --> 00:25:50,110
+على ربطه بمادة حمض الجلوكورونيك وتحويله إلى conjugated
+
+323
+00:25:50,110 --> 00:25:55,030
+bilirubin. إذا الـ unconjugated bilirubin يزداد في
+
+324
+00:25:55,030 --> 00:25:59,190
+حالة فقر الدم الانحلالي وحالات التهاب الكبد،
+
+325
+00:25:59,190 --> 00:26:04,540
+تمام؟  هنا قمنا بعمل جدول  يوضح الفرق بين الـ bilirubin
+
+326
+00:26:04,540 --> 00:26:09,120
+المرتبط بحمض الجلوكورونيك،  و الـ bilirubin
+
+327
+00:26:09,120 --> 00:26:13,560
+غير المرتبط الذي يخرج بسرعة من الهيموغلوبين
+
+328
+00:26:13,560 --> 00:26:18,020
+المتكسر، تمام؟ الـ conjugated bilirubin، الـ
+
+329
+00:26:18,020 --> 00:26:21,930
+bilirubin المرتبط، يُسمى الـ direct bilirubin، البلي
+
+330
+00:26:21,930 --> 00:26:26,130
+روبين المباشر.  الصفة الثانية له أنه water soluble،
+
+331
+00:26:26,130 --> 00:26:30,750
+ذائب في الماء، يعني ذائب في بلازما الدم، يعني يمر في
+
+332
+00:26:30,750 --> 00:26:35,730
+بلازما الدم بدون أي ناقل، بدون أي حامل، تمام
+
+333
+00:26:35,730 --> 00:26:41,770
+found in urine. أراه في البول، لأن جزء منه يذهب
+
+334
+00:26:41,770 --> 00:26:45,770
+إلى الكلى، وبالتالي يُخرج عن طريق
+
+335
+00:26:45,770 --> 00:26:53,500
+البول.  يُخرج عن طريق الكلى، وبالتالي
+
+336
+00:26:53,500 --> 00:27:02,060
+يخرج مع البول.  لا تحتاج إلى أي محفز أثناء التفاعل،
+
+337
+00:27:02,060 --> 00:27:05,880
+هذا ما سنراه أكثر شيء في التفاعل، يعني لا نحتاج في الـ
+
+338
+00:27:05,880 --> 00:27:10,000
+مجموعة  الاختبار الخاصة  بعامل التفاعل الخاص بالـ conjugated bilirubin
+
+339
+00:27:10,000 --> 00:27:16,000
+لا يكون هناك أي محفز.  أما الـ bilirubin
+
+340
+00:27:16,000 --> 00:27:20,960
+غير المرتبط، أو يُسمى غير مباشر، فهو water insoluble،
+
+341
+00:27:20,960 --> 00:27:25,000
+غير ذائب في الماء، يعني غير ذائب في بلازما الدم، عندما
+
+342
+00:27:25,000 --> 00:27:29,120
+يخرج من خلايا الدم الحمراء، يعني يخرج من الهيموغلوبين الذي
+
+343
+00:27:29,120 --> 00:27:34,180
+موجود داخل خلايا الدم الحمراء، يخرج ويصل إلى بلازما الدم، عندما يذهب
+
+344
+00:27:34,180 --> 00:27:38,760
+إلى الكبد، قلنا يأتي الألبومين الذي يحمله، الألبومين
+
+345
+00:27:38,760 --> 00:27:43,340
+عبارة عن بروتين يعمل كناقل، ينقل
+
+346
+00:27:43,340 --> 00:27:49,420
+الـ unconjugated bilirubin من الدم إلى الكبد. Not
+
+347
+00:27:49,420 --> 00:27:53,100
+found in urine.  لا أراه في البول ولا أراه
+
+348
+00:27:53,100 --> 00:27:57,560
+في البراز، تمام؟ needs accelerator. يعني أثناء
+
+349
+00:27:57,560 --> 00:28:03,160
+التفاعل، وفي التفاعل نحتاج إلى محفز. الـ total
+
+350
+00:28:03,160 --> 00:28:06,620
+bilirubin.  المجموعة،  عندما أقول لكم نريد فحص total
+
+351
+00:28:06,620 --> 00:28:12,780
+bilirubin،  معنى ذلك أن هذه المجموعة تحسب لي الـ conjugated
+
+352
+00:28:12,780 --> 00:28:16,660
+bilirubin زائد الـ unconjugated bilirubin، يعني
+
+353
+00:28:16,660 --> 00:28:20,760
+تحسب لي كل الـ bilirubin الموجود في بلازما الدم،
+
+354
+00:28:20,760 --> 00:28:25,380
+سواء المرتبط أو غير المرتبط،  يعني conjugated زائد
+
+355
+00:28:25,380 --> 00:28:29,200
+unconjugated bilirubin. Typically only the total
+
+356
+00:28:29,200 --> 00:28:33,640
+bilirubin is reported. عادةً يا جماعة،  الطبيب يطلب
+
+357
+00:28:33,640 --> 00:28:38,800
+الـ total bilirubin،  و نسجل نتيجته، لكن لو لاحظ
+
+358
+00:28:38,800 --> 00:28:42,300
+الطبيب أنه  يوجد مشكلة في الـ total bilirubin،
+
+359
+00:28:42,300 --> 00:28:46,780
+مثلًا الـ total bilirubin مرتفع، تمام؟  ساعتها
+
+360
+00:28:46,780 --> 00:28:50,990
+يُطلب  الـ direct و الـ indirect bilirubin، ساعتها
+
+361
+00:28:50,990 --> 00:28:55,410
+يُطلب فحص النوعين لمعرفة أين المشكلة
+
+362
+00:28:55,410 --> 00:28:59,170
+تماماً، المشكلة في الـ direct bilirubin أم الـ
+
+363
+00:28:59,170 --> 00:29:02,730
+indirect bilirubin؟ من الذي به مشكلة، ومن الذي
+
+364
+00:29:02,730 --> 00:29:07,110
+مرتفع، تمام؟ إذا كان الفحص الكلي به مشكلة، إذا
+
+365
+00:29:07,110 --> 00:29:12,350
+كان الفحص الكلي به مشكلة، تجارب تجارب تجارب
+
+366
+00:29:12,350 --> 00:29:13,970
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+367
+00:29:13,970 --> 00:29:15,330
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+368
+00:29:15,330 --> 00:29:16,930
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+369
+00:29:16,930 --> 00:29:17,210
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+370
+00:29:17,210 --> 00:29:17,370
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+371
+00:29:17,370 --> 00:29:22,290
+تجارب تجارب تجارب تجارب تجارب  فحص الـ direct
+
+372
+00:29:22,290 --> 00:29:27,090
+و الـ indirect،  الفحصين نقوم بهما على حدة لنرى أين
+
+373
+00:29:27,090 --> 00:29:30,150
+المشكلة تماماً، يعني نريد أن نفهم أن الـ direct bilirubin
+
+374
+00:29:30,150 --> 00:29:36,530
+له مجموعة اختبار و الـ indirect bilirubin  أيضاً له مجموعة اختبار.  ممكن
+
+375
+00:29:36,530 --> 00:29:40,270
+أن أقيس الـ total bilirubin بالمجموعة الخاصة به
+
+376
+00:29:40,270 --> 00:29:45,710
+وأطرحه، وأقوم بفحص الـ conjugated فقط،  وأطرحه من
+
+377
+00:29:45,710 --> 00:29:49,210
+الـ total،  ستظهر لي تركيز الـ unconjugated bilirubin
+
+378
+00:29:49,210 --> 00:29:52,570
+أو العكس، total bilirubin ناقص
+
+379
+00:29:52,570 --> 00:29:56,990
+unconjugated  سيظهر لي الـ conjugated،  يعني ممكن أن أقوم بفحص
+
+380
+00:29:56,990 --> 00:30:00,690
+الـ total bilirubin وأقوم بفحص واحد من الاثنين،
+
+381
+00:30:00,690 --> 00:30:06,200
+وأطرحه من الآخر، سيظهر لي الثالث، واضح؟ For clinical
+
+382
+00:30:06,200 --> 00:30:11,220
+significance.  أهمية الفحص، الحالات التي يزداد فيها الـ
+
+383
+00:30:11,220 --> 00:30:14,720
+conjugated bilirubin. الحالة الأولى، ذكرناها، الـ
+
+384
+00:30:14,720 --> 00:30:18,700
+انسداد القناة الصفراوية، انسداد في القناة الصفراوية، في
+
+385
+00:30:18,700 --> 00:30:23,080
+القناة الصفراوية. فإن الـ conjugated bilirubin
+
+386
+00:30:23,080 --> 00:30:28,130
+يتكون في الكبد،  يجب أن يخرج، قلنا يمر
+
+387
+00:30:28,130 --> 00:30:32,090
+عبر القناة الصفراوية، ثم يذهب إلى الأمعاء لكي
+
+388
+00:30:32,090 --> 00:30:36,450
+يخرج مع البراز،  ولكن لو وجد حصى في هذه
+
+389
+00:30:36,450 --> 00:30:40,870
+القناة، لن يستطيع المرور فيها، وبالتالي سيعود بشكل
+
+390
+00:30:40,870 --> 00:30:46,010
+عكسي إلى الكبد مرة أخرى،  ثم سيذهب إلى بلازما
+
+391
+00:30:46,010 --> 00:30:51,590
+الدم، ويزيد تركيزه في الدم، تمام؟ الحالة الثانية،
+
+392
+00:30:51,590 --> 00:30:56,010
+سرطان رأس البنكرياس، حدوث سرطان في
+
+393
+00:30:56,010 --> 00:31:01,970
+رأس البنكرياس
+
+445
+00:35:07,930 --> 00:35:11,850
+عنده Crigler-Najjar Syndrome، يعني مش هيتم تصنيع
+
+446
+00:35:11,850 --> 00:35:17,490
+هذا الـEnzyme في الكبد بسبب مشكلة وراثية، بالتالي مش
+
+447
+00:35:17,490 --> 00:35:22,290
+هيصير ارتباط للـUnconjugated bilirubin، مش هيتم
+
+448
+00:35:22,290 --> 00:35:25,870
+ربطه بالـGlucuronic Acid، وبالتالي إيش المحصلة؟ أن
+
+449
+00:35:25,870 --> 00:35:30,110
+الـUnconjugated bilirubin هيظل عالي في بلازما الدم
+
+450
+00:35:30,110 --> 00:35:32,830
+على الفاضي، هييجي على الكبد، على الفاضي، الكبد مش
+
+451
+00:35:32,830 --> 00:35:38,290
+هيقدر يعمل ربط لأنه ما فيش إنزايم جواه يعمل هذا
+
+452
+00:35:38,290 --> 00:35:43,680
+الربط. حالات الـGilbert Syndrome، الـGilbert
+
+453
+00:35:43,680 --> 00:35:47,760
+Syndrome، اللي جات الـUnconjugated بيليروبين طلع
+
+454
+00:35:47,760 --> 00:35:52,720
+من الـRBCs، مين الـcarrier له؟ مين اللي حمله على
+
+455
+00:35:52,720 --> 00:35:56,780
+الكبد؟ حكينا الألبومين، هذا ناقل للـUnconjugated
+
+456
+00:35:56,780 --> 00:36:02,010
+بيليروبين، لأنه ما بيقدر يمشي في بلازما الدم، بنحملها
+
+457
+00:36:02,010 --> 00:36:06,090
+وبالتالي، وراحوا على الكبد. هل وصلت قبل ما يفوتوا
+
+458
+00:36:06,090 --> 00:36:10,310
+الكبد يا جماعة؟ فيه Receptor على سطح الكبد، تمام؟
+
+459
+00:36:10,310 --> 00:36:14,650
+هذا الـReceptor، الـUnconjugated Bilirubin بيرتبط
+
+460
+00:36:14,650 --> 00:36:18,370
+عليه، وبعدين الكبد بيسحب الـUnconjugated Bili-
+
+461
+00:36:18,370 --> 00:36:21,690
+rubin للداخل. لكن الناس اللي عندهم Gilbert
+
+462
+00:36:21,690 --> 00:36:27,460
+Syndrome بيكون عندهم بشكل وراثي مشكلة في الـ
+
+463
+00:36:27,460 --> 00:36:31,540
+Receptor اللي موجودة على سطح الكبد، اللي بده يرتبط
+
+464
+00:36:31,540 --> 00:36:35,580
+فيها الـUnconjugated bilirubin عشان يدخل لجوة
+
+465
+00:36:35,580 --> 00:36:39,600
+الكبد. عشان هيك في حالات الـGilbert Syndrome أصلاً
+
+466
+00:36:39,600 --> 00:36:42,720
+الـUnconjugated bilirubin ما بيقدر يفوت جوة الكبد
+
+467
+00:36:42,720 --> 00:36:47,000
+فهيضل عالي في بلازما الدم. حالات الـHemolytic
+
+468
+00:36:47,000 --> 00:36:50,840
+Transfusion Reaction، يعني عمليات نقل الدم، في ناس
+
+469
+00:36:50,840 --> 00:36:54,430
+كتير بنقول لهم بعد فترة بيصير عندهم Hemolysis
+
+470
+00:36:54,430 --> 00:37:00,670
+أو نقلنا له دم فصيلة غير فصيلته، تمام؟ المحصلة
+
+471
+00:37:00,670 --> 00:37:04,790
+هيصير في تكسير للـRBCs بكميات أكبر، يعني تكسير
+
+472
+00:37:04,790 --> 00:37:08,710
+للـHemoglobin، يعني خروج الـUnconjugated bilirubin
+
+473
+00:37:08,710 --> 00:37:14,490
+بشكل مهول من الـRBCs. حالات الـHepatitis،  اتفقنا لما
+
+474
+00:37:14,490 --> 00:37:18,570
+خلايا الكبد يكون فيها مشكلة، يكون فيها التهاب، بيجي
+
+475
+00:37:18,570 --> 00:37:22,330
+الـUnconjugated bilirubin بده يتحول لـConjugated
+
+476
+00:37:22,330 --> 00:37:26,150
+bilirubin، خلايا الكبد ما بتقدر تحوله لأنه فيها
+
+477
+00:37:26,150 --> 00:37:31,310
+مشكلة. المحصلة إن الـUnconjugated bilirubin تركيزه
+
+478
+00:37:31,310 --> 00:37:36,810
+بارتفاع في الدم، تمام؟ طبعاً يا جماعة التفسير إن
+
+479
+00:37:36,810 --> 00:37:41,970
+هذه الـSyndromes، إيش هي هذا الكلام؟ لا مش هتضبكوا
+
+480
+00:37:41,970 --> 00:37:47,870
+فيه، فقط للمعرفة بس، إن الحالات المهمة هذه، يعني بدنا
+
+481
+00:37:47,870 --> 00:37:50,630
+نعرف إيش الحالات اللي بيزيد فيها الـConjugated و
+
+482
+00:37:50,630 --> 00:37:53,690
+الحالات اللي بيزيد فيها الـUnconjugated، ومش ضروري
+
+483
+00:37:53,690 --> 00:37:57,150
+التفسير اللي أنا شرحته، فقط للعلم، تمام؟
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/8z-8bV0QAco_postprocess.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/8z-8bV0QAco_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..c85483e82c603dbbe1a64fabcab7ea41a449a0b6
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/8z-8bV0QAco_postprocess.srt
@@ -0,0 +1,1932 @@
+1
+00:00:01,030 --> 00:00:04,290
+السلام عليكم ورحمة الله وبركاته يعطيكم العافية
+
+2
+00:00:04,290 --> 00:00:08,030
+جميعا ان شاء الله اليوم محاضرتنا بعنوان Billy
+
+3
+00:00:08,030 --> 00:00:09,270
+Robin Test
+
+4
+00:00:11,590 --> 00:00:15,170
+one of the most important liver functions and one
+
+5
+00:00:15,170 --> 00:00:18,930
+that is distributed in a large number of diseases
+
+6
+00:00:18,930 --> 00:00:24,910
+is the excretion of bile بيحكيلي واحدة من أهم
+
+7
+00:00:24,910 --> 00:00:29,530
+الوظائف اللي بيشتغل فيها ال liver ويمكن حكيناها
+
+8
+00:00:29,530 --> 00:00:33,370
+المعمل اللي فات انه مسئول عن تصنيع ال bile acid
+
+9
+00:00:33,370 --> 00:00:38,550
+العصارة السفراوية والعصارة السفراوية حكينا بتساعد
+
+10
+00:00:38,550 --> 00:00:43,770
+ال liver بعد ما يكونهابعمللها execution بيوديها
+
+11
+00:00:43,770 --> 00:00:49,470
+وبتنتقل عبر القناة الصفرية للأمعاء عشان هناك الـ
+
+12
+00:00:49,470 --> 00:00:55,610
+bile acid بيتساعد في هضم الدهون، تمام؟فواحدة من
+
+13
+00:00:55,610 --> 00:01:02,310
+وظائف الـ Liver المهمة إنه بعمل Execration للـ
+
+14
+00:01:02,310 --> 00:01:07,190
+Bile Acid للعصارة السفرية وبتمشي عبر قناة اسمها
+
+15
+00:01:07,190 --> 00:01:11,730
+الـ Biliary Duct اللي هي قناة العصارة السفرية
+
+16
+00:01:11,730 --> 00:01:15,950
+بتمشي من الكبد وبتروح على الأمعاء عشان تساعد في
+
+17
+00:01:15,950 --> 00:01:21,450
+هضم الدهون أيضًا الـ Execration of bile خروج هذه
+
+18
+00:01:21,450 --> 00:01:25,990
+العصارة من الكبدممكن يصير فيه أحيانًا الـproblem
+
+19
+00:01:25,990 --> 00:01:30,430
+ويصير فيه مشكلة في عملية الـexecration لهذه
+
+20
+00:01:30,430 --> 00:01:37,390
+العصارة السفرية، تمام؟Bile comprises bile acids or
+
+21
+00:01:37,390 --> 00:01:41,830
+salts بيحكيلي إنه العصارة السفروية يا بيسموها bile
+
+22
+00:01:41,830 --> 00:01:46,890
+acid أو bile salt عبارة عن شو؟ بتتكون من شو هذه ال
+
+23
+00:01:46,890 --> 00:01:50,610
+bile acid و ال bile salt عبارة عن bile pigments
+
+24
+00:01:50,610 --> 00:01:55,110
+and others يعني هي عصارة سفروية ومن اسمها سفروية
+
+25
+00:01:55,110 --> 00:02:00,590
+يعني في مادة كيميائية تعطيها اللون الأصفر تعطيها
+
+26
+00:02:00,590 --> 00:02:05,760
+ديالعصارة السفرية اللون الأصفر تمام؟ هنشوف شو هي
+
+27
+00:02:05,760 --> 00:02:10,320
+المادة بالي روبين is the principal pigment in the
+
+28
+00:02:10,320 --> 00:02:15,180
+bile ال بالي روبين هذه المادة الكيميائية هي اللي
+
+29
+00:02:15,180 --> 00:02:20,620
+بتعطي العصارة السفرية اللون اليلو اللون الأصفر
+
+30
+00:02:20,620 --> 00:02:26,700
+تمام؟بلي روبن derived from breakdown of hemoglobin
+
+31
+00:02:26,700 --> 00:02:30,900
+بلي روبن من وين جاي؟ جاي من تكسير ال hemoglobin
+
+32
+00:02:30,900 --> 00:02:36,160
+هلجيت يا جماعة ال RBCs جديش عمرها 120 يوم كل 120
+
+33
+00:02:36,160 --> 00:02:40,180
+يوم ال RBCs بتتكسر و بتطلع بدالها لما بتتكسر ال
+
+34
+00:02:40,180 --> 00:02:44,600
+RBCs بتطلع ال hemoglobin منها أيضا ال hemoglobin
+
+35
+00:02:44,600 --> 00:02:49,060
+هو بروتين له عمر معين له half-life معين أيضا
+
+36
+00:02:49,060 --> 00:02:53,770
+بيتكسرلمّا بتكسّر الـ Hemoglobin كلكم عارفين،
+
+37
+00:02:53,770 --> 00:02:58,330
+بعطيني الـ Hem-group الـ Hem-group و الـ Globin
+
+38
+00:02:58,330 --> 00:03:04,390
+-group أيضًا الـ Hem-group لما يتكسّر حاصل تكسير
+
+39
+00:03:04,390 --> 00:03:09,050
+الـ Hem-group تتكون عند مادة الـ Bilirubin يعني لو
+
+40
+00:03:09,050 --> 00:03:13,190
+سألناكوا المادة الكيميائية الـ Bilirubin من وين
+
+41
+00:03:13,190 --> 00:03:17,510
+جاية؟ جاية من تكسير الـ Hem اللي موجود في الـ
+
+42
+00:03:17,510 --> 00:03:21,360
+Hemoglobinبس إحنا تجاوزاً ع السريع بنحكي جاية من
+
+43
+00:03:21,360 --> 00:03:25,780
+تكسير الـ Hemoglobin، تمام؟ إذا في هاي الـ slide
+
+44
+00:03:25,780 --> 00:03:29,540
+يعني معلومات عامة بس أنا بدي أركز إن الـBilly
+
+45
+00:03:29,540 --> 00:03:33,800
+Robin جاية من تكسير الـHemoglobin اللي موجود في
+
+46
+00:03:33,800 --> 00:03:38,440
+الـRBCs وتكسير بالظبط إيش الـHeme Group، تمام؟
+
+47
+00:03:41,770 --> 00:03:48,390
+بيلي روبن هناك نوعين من البيلي روبن من هذه المادة
+
+48
+00:03:48,390 --> 00:03:52,150
+الكيميائية النوع الأول بيسموه conjugated أو
+
+49
+00:03:52,150 --> 00:03:57,590
+indirect بيلي روبن البيلي روبن المرتبط أما النوع
+
+50
+00:03:57,590 --> 00:04:02,030
+الآخر هو ال unconjugated بيلي روبن أو بيسموه
+
+51
+00:04:02,030 --> 00:04:08,180
+indirect بيلي روبن هو البيلي روبن الغير مرتبطtotal
+
+52
+00:04:08,180 --> 00:04:12,040
+bilirubin is composed of the conjugated bilirubin
+
+53
+00:04:12,040 --> 00:04:15,760
+plus the unconjugated bilirubin يعني لما أحكيلك
+
+54
+00:04:15,760 --> 00:04:20,340
+اعمليلي فحص ال total bilirubin في الدم يعني بدك
+
+55
+00:04:20,340 --> 00:04:24,820
+تحسبي ال unconjugated bilirubin ال bilirubin الغير
+
+56
+00:04:24,820 --> 00:04:30,080
+مرتبط زائد ال conjugated bilirubin ال bilirubin
+
+57
+00:04:30,080 --> 00:04:35,140
+المرتبط تجمعيهم مع بعض بتطلعلك ال total bilirubin
+
+58
+00:04:35,140 --> 00:04:41,860
+ككل تمام؟هلجيت شو الفرج بين النوعين؟ والتانين
+
+59
+00:04:41,860 --> 00:04:48,160
+بيكونوا موجودين في بلازمة الدم النوع المرتبط
+
+60
+00:04:48,160 --> 00:04:54,980
+والنوع الغير مرتبط هلجيت لو جينا مع بعض نشوف كل
+
+61
+00:04:54,980 --> 00:04:58,780
+نوع وين بلاجيه؟هل جيت يا جماعة كلكوا عارفين إن
+
+62
+00:04:58,780 --> 00:05:05,220
+الـRBCs عمرها 120 يوم وبعد 120 يوم بتتكسر لما
+
+63
+00:05:05,220 --> 00:05:09,140
+بتتكسر الـRBCs بتطلع منها الـHemoglobin أيضا
+
+64
+00:05:09,140 --> 00:05:13,660
+الـHemoglobin بيتكسر حاصل تكسير الـHemoglobin
+
+65
+00:05:13,660 --> 00:05:18,280
+بعطيني Billy Robin طب هذا الـBilly Robin إيش نوعه
+
+66
+00:05:18,280 --> 00:05:22,670
+اللي جاي من تكسير الـHemoglobin؟نوعه Unconjugated
+
+67
+00:05:22,670 --> 00:05:26,830
+bilirubin بيلي روبين غير مرتبط يعني لو سألناكم
+
+68
+00:05:26,830 --> 00:05:31,450
+سؤال شو نوع الـ bilirubin اللي جاي من تكسير الـ
+
+69
+00:05:31,450 --> 00:05:37,480
+Hemoglobinواللي بالأخص جاي من تكسير الـ hemagroup
+
+70
+00:05:37,480 --> 00:05:41,840
+اللي موجودة في الـ Hemoglobin هتحكولي نوعه Billy
+
+71
+00:05:41,840 --> 00:05:46,520
+Robin غير مرتبط Unconjugated Billy Robin هلجيت لما
+
+72
+00:05:46,520 --> 00:05:50,820
+اتكسرت الـ RBCs و اتكسر الـ Hemoglobin وطلع الـ
+
+73
+00:05:50,820 --> 00:05:54,740
+Unconjugated Billy Robinعلى الدم هذا الـ
+
+74
+00:05:54,740 --> 00:05:58,100
+Unconjugated bilirubin الـ bilirubin غير مرتبط هذا
+
+75
+00:05:58,100 --> 00:06:02,900
+خطير جدا ممنوع يظل في الدم زي و زي الأمونيا إذا
+
+76
+00:06:02,900 --> 00:06:07,420
+بتتذكروا المعمل اللي فات تمام فمادة الأمونيا سامة
+
+77
+00:06:07,420 --> 00:06:12,880
+أيضا مادة الـ Unconjugated bilirubin سام ليش؟ لأن
+
+78
+00:06:12,880 --> 00:06:17,820
+هذه المادة ممكن تخترق غشاء الدماغ وتفوت على الدماغ
+
+79
+00:06:17,820 --> 00:06:22,110
+وتعمل مشاكل وممكن تؤدي إلى الوفاةلو ارتفع الـ
+
+80
+00:06:22,110 --> 00:06:26,210
+Unconjugated Billy Robin في الدم عشان هيك يا جماعة
+
+81
+00:06:27,060 --> 00:06:31,320
+الـ Unconjugated bilirubin موجود في بلازمة الدم
+
+82
+00:06:31,320 --> 00:06:36,520
+ولكن بتركيز قليل جدا تمام؟ at very very low
+
+83
+00:06:36,520 --> 00:06:41,400
+concentration طيب كيف الجسم بتخلص؟ بما أنه سامل
+
+84
+00:06:41,400 --> 00:06:45,660
+الدم و سامل الدماغ يفترض الجسم يتخلص منه هذا الـ
+
+85
+00:06:45,660 --> 00:06:50,440
+Unconjugated bilirubin طيب كيف الجسم بتخلص منه؟
+
+86
+00:06:50,440 --> 00:06:57,100
+بيروح على الكبد وفي الكبديتم التخلص من الـ
+
+87
+00:06:57,100 --> 00:07:01,740
+Unconjugated bilirubin هو بيظل جزء منه موجود في
+
+88
+00:07:01,740 --> 00:07:08,080
+بلازم الدم ولكن بتركيز قليلة جدا أما الكمية الأكبر
+
+89
+00:07:08,080 --> 00:07:11,920
+لازم الجسم يتخلص منها ومين بتخلص من الـ
+
+90
+00:07:11,920 --> 00:07:17,840
+Unconjugated bilirubin هو الكبد، تمام؟تمام نشوف
+
+91
+00:07:17,840 --> 00:07:21,920
+النقطة التالتة الـ Total bilirubin level increases
+
+92
+00:07:21,920 --> 00:07:26,300
+with any type of jaundice كلنا بنسمع بيه مرض
+
+93
+00:07:26,300 --> 00:07:32,480
+الصفار تمام بيكون الشخص وجهه أصفر أصفر ممكن يتطور
+
+94
+00:07:32,480 --> 00:07:37,000
+الوضع العينين عنده تكون صفرة كتير المنطقة البيضة
+
+95
+00:07:37,000 --> 00:07:40,800
+اللي في العين بتكون صفرة كتير هذا بيسميه صفار لما
+
+96
+00:07:40,800 --> 00:07:45,760
+الإنسان نحكي عنده صفارمعناه لو فحصتله الـ total
+
+97
+00:07:45,760 --> 00:07:52,560
+بيلي روبين عنده هيكون عالي كتير تمام؟ هنودح هذه
+
+98
+00:07:52,560 --> 00:07:56,740
+الجملة في الفقرات التانية أو في الـ slides التانية
+
+99
+00:07:56,740 --> 00:08:03,080
+تمام؟ الـ metabolism of بيلي روبين نشوف بالظبط كيف
+
+100
+00:08:03,080 --> 00:08:07,580
+الـ Billy Robin بتكون و أين بيروح و كيف بيه الجسم
+
+101
+00:08:07,580 --> 00:08:14,700
+بتخلص منه لأنه مادة ثمة تمام؟أول إشي حكينا إنه
+
+102
+00:08:14,700 --> 00:08:19,360
+تابعوا معايا على الـ Chart فوق في المربع هذا
+
+103
+00:08:19,360 --> 00:08:23,080
+المكان في الـ reticuloendothelial system في
+
+104
+00:08:23,080 --> 00:08:29,260
+الأماكن اللي بيصير فيها تكسير للـ RBCs لما بيخلص
+
+105
+00:08:29,260 --> 00:08:34,980
+عمرها إذا اتفجنا إن الـ RBCs عمرها 120 يوملما
+
+106
+00:08:34,980 --> 00:08:40,040
+بتخلص عمرها تتكسر بيصير release لالهيموجلوبين
+
+107
+00:08:40,040 --> 00:08:44,160
+بيطلع الهيموجلوبين منها الهيموجلوبين أيضا بتكسر
+
+108
+00:08:44,160 --> 00:08:49,960
+لهيم و Globin اجروا الهيم حكينا برضه بيتكسر الهيم
+
+109
+00:08:49,960 --> 00:08:56,080
+اللي بيتكسر نتيجة تكسير الهيم تتكون عندى مادة الـ
+
+110
+00:08:56,080 --> 00:09:00,960
+Unconjugated bilirubin الـ bilirubin الغير مرتبط
+
+111
+00:09:01,910 --> 00:09:06,330
+هلجيت بعد ما يتكون أو يطلع الـUnconjugated
+
+112
+00:09:06,330 --> 00:09:12,090
+bilirubin من الهيم، من حاصل تكسير الهيم، بيروح على
+
+113
+00:09:12,090 --> 00:09:17,410
+بلازمة الدم. اتفجنا إنه في البلازمة ممنوع
+
+114
+00:09:17,410 --> 00:09:21,670
+الـUnconjugated bilirubin يكون بتركيز عالي، لأن
+
+115
+00:09:21,670 --> 00:09:26,410
+مادة دسم ما ممكن تخترق غشاء الدماغ، وبتأدي إلى
+
+116
+00:09:26,410 --> 00:09:31,600
+الوفاة، وجوده.فهو موجود في بلازمة الدم في الوضع
+
+117
+00:09:31,600 --> 00:09:35,980
+الطبيعي at very low concentration بتركيز قليل جدا
+
+118
+00:09:35,980 --> 00:09:42,000
+عشان هيك الجسم بده يتخلص من الـ Unconjugated
+
+119
+00:09:42,000 --> 00:09:46,930
+bilirubin كيف؟للأسف الـ Unconjugated bilirubin هذا
+
+120
+00:09:46,930 --> 00:09:51,110
+زي و زي الدهون Insoluble في بلازمة الدم، بقدرش
+
+121
+00:09:51,110 --> 00:09:55,390
+يمشي غير دائب في بلازمة الدم، بقدرش يمشي في
+
+122
+00:09:55,390 --> 00:10:00,440
+البلازمة لحاله، بده career، بده ناقلفبيجي عند الـ
+
+123
+00:10:00,440 --> 00:10:05,260
+Albumin عبارة عن بروتين ناقل للـ Unconjugated
+
+124
+00:10:05,260 --> 00:10:10,040
+bilirubin بيحمل الـ Unconjugated bilirubin من الـ
+
+125
+00:10:10,040 --> 00:10:14,100
+plasma الدم إلى الـ liver إلى الكبت تبعه على الـ
+
+126
+00:10:14,100 --> 00:10:19,000
+chart خطوة خطوة، تمام؟إذن الـ Unconjugated
+
+127
+00:10:19,000 --> 00:10:24,000
+bilirubin معظمه وصل للـ liver وضال تركيز قليل منه
+
+128
+00:10:24,000 --> 00:10:28,600
+موجود في إبلازم الدم وهذا الوضع الطبيعي هلجت في
+
+129
+00:10:28,600 --> 00:10:34,420
+الكبد الـ Unconjugated bilirubin لازم أحوله لمادة
+
+130
+00:10:34,420 --> 00:10:39,620
+يعني تكون أقل سمية منه الـ Unconjugated bilirubin
+
+131
+00:10:39,620 --> 00:10:46,420
+بدو يتحول في الكبد لمادة أخرىهذه المادة الأخرى أقل
+
+132
+00:10:46,420 --> 00:10:50,080
+سمية من الـ Unconjugated bilirubin وبعد ذلك هذه
+
+133
+00:10:50,080 --> 00:10:55,340
+المادة الجسم بستطيع أن يتخلص منها بكل سهولة ففي
+
+134
+00:10:55,340 --> 00:10:59,320
+الكبد يوجد هناك أنزين مش بالضرورة نعرف اسمه هتاخده
+
+135
+00:10:59,320 --> 00:11:04,820
+في النظري مع الدكتور مازنهذا الـ enzyme إيش بيعمل؟
+
+136
+00:11:04,820 --> 00:11:09,960
+بيروح يربط الـ unconjugated bilirubin بمادة اسمها
+
+137
+00:11:09,960 --> 00:11:14,260
+الـ glucuronic acid ارتباط الـ unconjugated
+
+138
+00:11:14,260 --> 00:11:20,300
+bilirubin بمادة الـ glucuronic acid هيعطيني مركب
+
+139
+00:11:20,300 --> 00:11:25,360
+سموه conjugated bilirubin الـ bilirubin المرتبط
+
+140
+00:11:25,360 --> 00:11:30,300
+ليش حكيت عنه bilirubin مرتبط؟ لأن هو عبارة عنالـ
+
+141
+00:11:30,300 --> 00:11:33,960
+Unconjugated bilirubin الـ bilirubin غير مرتبط
+
+142
+00:11:33,960 --> 00:11:39,800
+ربطوه في مادة اسمها Glucuronic Acid فطلع عندي مركب
+
+143
+00:11:39,800 --> 00:11:46,900
+اسمه Bilirubin-Diglucuronate هذا هو الـ Conjugated
+
+144
+00:11:46,900 --> 00:11:50,420
+bilirubin هو الـ bilirubin المرتبط ربطوه في
+
+145
+00:11:50,420 --> 00:11:55,860
+Glucuronic Acid من ربطه الكبد بواسطة انزايم موجود
+
+146
+00:11:55,860 --> 00:12:01,210
+فيه تمام؟ففي الكابت اتحول الـ Unconjugated
+
+147
+00:12:01,210 --> 00:12:06,590
+bilirubin لـ Conjugated bilirubin تمام؟ هالجيت
+
+148
+00:12:06,590 --> 00:12:12,410
+الكابت هياخد جزء بسيط من هذا الـ Conjugated
+
+149
+00:12:12,410 --> 00:12:17,930
+bilirubin عبر أوردة و شرايين و يوديه على بلازمة
+
+150
+00:12:17,930 --> 00:12:23,310
+الدم إذا أصبح في بلازمة الدمفي عيننا الـ
+
+151
+00:12:23,310 --> 00:12:27,230
+Unconjugated bilirubin والـ Conjugated bilirubin
+
+152
+00:12:27,230 --> 00:12:31,650
+يعني أنه عين موجودين في بلازم الدم وبتراكيز قليلة
+
+153
+00:12:31,650 --> 00:12:38,080
+هذا الوضع الطبيعي تمام؟تمام طيب الـ conjugated
+
+154
+00:12:38,080 --> 00:12:43,140
+bilirubin حكينا جزء بسيط بواسطة الكبت و شرينه أو
+
+155
+00:12:43,140 --> 00:12:47,820
+ردته تم إيصاله لبلازمة الدم طيب الجزء الكبير اللي
+
+156
+00:12:47,820 --> 00:12:51,600
+ضايل ال conjugated bilirubin وين بدي يروح الجسم
+
+157
+00:12:51,600 --> 00:12:57,050
+بده يتخلص منه؟الـ Conjugated Billy-Robin بيروح
+
+158
+00:12:57,050 --> 00:13:04,130
+الكبد وهو عمله Execration بواسطة الـ Biliary Duct
+
+159
+00:13:04,130 --> 00:13:09,190
+شايفين؟ هي الكبد بعد الكبد مكتوب عندكوا الـ Bile
+
+160
+00:13:09,190 --> 00:13:14,150
+يعني الـ Biliary Duct يعني القناة السفرية هيمشي
+
+161
+00:13:14,150 --> 00:13:20,030
+الـ Conjugated Billy-Robinعبر القناة السفرية ويظل
+
+162
+00:13:20,030 --> 00:13:24,490
+ماشي لحد ما يصل لـ Small Intestine الأمعاء الدقيقة
+
+163
+00:13:24,490 --> 00:13:28,430
+تمام؟ هذه عندكم الأمعاء الدقيقة وهي الـ Conjugated
+
+164
+00:13:28,430 --> 00:13:35,520
+bilirubin واصل عندها تمام؟هلجيت في الأمعاء الضقيقة
+
+165
+00:13:35,520 --> 00:13:42,200
+فى عنا بكتيريا الـ Normaliflora هتحول المادة الـ
+
+166
+00:13:42,200 --> 00:13:47,460
+Conjugated bilirubin لمادة اسمها الـ Uropilinogen
+
+167
+00:13:47,460 --> 00:13:53,160
+تمام؟ يمكن سمعتوا فيها تمام بعدين مادة الـ
+
+168
+00:13:53,160 --> 00:13:57,900
+Uropilinogen اللى اتكونت في الأمعاء الضقيقة هتمشى
+
+169
+00:13:57,900 --> 00:14:04,140
+على الـ Large Intestine الأمعاء الغليظةوهناك برضه
+
+170
+00:14:04,140 --> 00:14:08,240
+هيصير فيه Oxidation أكسدة يعني في الأمعاء الغليظة
+
+171
+00:14:08,240 --> 00:14:13,120
+هيتم أكسدة الـUropilinogen وتحويله لمادة
+
+172
+00:14:13,120 --> 00:14:20,420
+الـUropilinبعد هيك المادة الـ European هتطلع مع
+
+173
+00:14:20,420 --> 00:14:26,600
+الستول خارج الجثم وبهيك الإنسان اتخلص من الـ
+
+174
+00:14:26,600 --> 00:14:30,900
+conjugated باليروبين عن طريق عمل له execution مع
+
+175
+00:14:30,900 --> 00:14:37,510
+الستول، تمام؟ هي طريقةالطريقة الأخرى أيضًا جزء من
+
+176
+00:14:37,510 --> 00:14:42,890
+الـUropilinogen قبل ما يتأكسد لـUropilin بيروح عبر
+
+177
+00:14:42,890 --> 00:14:50,230
+شرايين وأوردة بيصل الكدن تمام؟ بيصل الكلاوالكله
+
+178
+00:14:50,230 --> 00:14:56,130
+بتعمل Execration لمادة الـUropilinogen عن طريق مع
+
+179
+00:14:56,130 --> 00:14:59,530
+الـUrine يعني بتطلع الـUropilinogen مع الـUrine
+
+180
+00:14:59,530 --> 00:15:05,030
+وهذا بيثبت كلام لو جينا فحصنا الـUrine بالـStrip
+
+181
+00:15:05,030 --> 00:15:09,170
+تمام؟ مش فيه خانة لمادة الـUropilinogen يعني
+
+182
+00:15:09,170 --> 00:15:13,050
+تجاوزاً هي الـConjugated Bilirubin موجود في
+
+183
+00:15:13,050 --> 00:15:17,810
+الـUrine ولا مش موجود تمام؟ إذا نعيد لـChart كسرت
+
+184
+00:15:17,810 --> 00:15:23,440
+الـRBCsطلع الـ Hemoglobin منها الـ Hemoglobin
+
+185
+00:15:23,440 --> 00:15:28,440
+اتكسر طلع منه Unconjugated bilirubin ضال جزء منه
+
+186
+00:15:28,440 --> 00:15:32,800
+في البلازمة لكن كمية الأكبر لازم الجسم يتخلص منها
+
+187
+00:15:32,800 --> 00:15:38,580
+فبيروح على الكبد من خلال ناقل الألبومين بنجلوا على
+
+188
+00:15:38,580 --> 00:15:43,040
+الكبد لأنه غير ذائب في بلازمة الدم وفي الكبد هذا
+
+189
+00:15:43,040 --> 00:15:47,200
+الـ Unconjugated بتم ربطه بمادة الـ Glucuronic
+
+190
+00:15:47,200 --> 00:15:52,270
+Acidفبتكون عندى مُركّب الـ conjugated bilirubin
+
+191
+00:15:52,270 --> 00:15:56,470
+الـ bilirubin المرتبط تمام؟ هذا الـ bilirubin
+
+192
+00:15:56,470 --> 00:16:04,310
+المرتبط بتم أخذ جزء منه قليل جدا و بتم إيصاله إلى
+
+193
+00:16:04,310 --> 00:16:09,790
+البلازم الدم أما الكمية الأكبر الجسم بتخلص منها
+
+194
+00:16:09,790 --> 00:16:15,130
+إما عن طريق الـ stool أو عن طريق الـ urineمش إما
+
+195
+00:16:15,130 --> 00:16:18,390
+يعني بتخلص منه بالـ stool والـ urine يعني
+
+196
+00:16:18,390 --> 00:16:24,150
+الطريقتين كيف أن هذا الـ conjugated bilirubin بمشي
+
+197
+00:16:24,150 --> 00:16:27,850
+في الـ bilary duct في القناة الصفروية لحد ما يصل
+
+198
+00:16:27,850 --> 00:16:31,610
+الأمعاء الدقيقة وفي الأمعاء الدقيقة هناك بكتيريا
+
+199
+00:16:31,610 --> 00:16:37,230
+بتحوله لمادة europlenosinالـUropilinogen إما بيروح
+
+200
+00:16:37,230 --> 00:16:41,670
+على الـ يعني مش إما يعني هو جزء منه بيروح على
+
+201
+00:16:41,670 --> 00:16:46,930
+الكلمة و بيصيرله execution مع الـ urine و جزء منه
+
+202
+00:16:46,930 --> 00:16:54,150
+بتأكسد في الأمعاء الغليظة و بتحول لمادة Uropilin و
+
+203
+00:16:54,150 --> 00:16:59,410
+اللي بيصيرلها execution عن طريق الـ feces، تمام؟
+
+204
+00:16:59,410 --> 00:17:05,890
+هيك افهمنا الـ metabolism تبع الـ Billy Robinالـ
+
+205
+00:17:05,890 --> 00:17:09,890
+Conjugated bilirubin بشكل عام أو مباشر أو مباشر
+
+206
+00:17:09,890 --> 00:17:10,850
+بشكل عام أو مباشر أو مباشر بشكل عام أو مباشر بشكل
+
+207
+00:17:10,850 --> 00:17:12,290
+عام أو مباشر بشكل عام أو مباشر بشكل عام أو مباشر
+
+208
+00:17:12,290 --> 00:17:13,270
+بشكل عام أو مباشر بشكل عام أو مباشر بشكل عام أو
+
+209
+00:17:13,270 --> 00:17:13,910
+مباشر بشكل عام أو مباشر بشكل عام أو مباشر بشكل عام
+
+210
+00:17:13,910 --> 00:17:14,450
+أو مباشر بشكل عام أو مباشر بشكل عام أو مباشر بشكل
+
+211
+00:17:14,450 --> 00:17:14,630
+عام أو مباشر بشكل عام أو مباشر بشكل عام أو مباشر
+
+212
+00:17:14,630 --> 00:17:17,000
+مباشر بشكل عامwith only minimal amounts entering
+
+213
+00:17:17,000 --> 00:17:19,900
+the bloodstream حكينا بهذا الموضوع أن الـ
+
+214
+00:17:19,900 --> 00:17:23,840
+bilirubin المرتبط اللي اتكون فيه الكبت بعد ما
+
+215
+00:17:23,840 --> 00:17:31,000
+يتكون جزء منه بيروح ع بلازم الدم وجزء قليل جدا أما
+
+216
+00:17:31,000 --> 00:17:35,680
+الكمية المتبقية الجسم بتخلص منها بتخلص منها
+
+217
+00:17:35,680 --> 00:17:39,740
+الطريقتين بال gastrointestinal tract يعني بواسطة
+
+218
+00:17:39,810 --> 00:17:44,890
+الجهاز الغضبي لأنه حكينا الـ Conjugated بيمشي
+
+219
+00:17:44,890 --> 00:17:49,410
+بالقناة السفرية بيروح لأمعاء دقيقة بعدين الأمعاء
+
+220
+00:17:49,410 --> 00:17:55,070
+الغليظة وبعدين Execration مع الفيسس بطلع مع الفيسس
+
+221
+00:17:55,070 --> 00:18:00,870
+تمام؟ أيضا الجسم بتخلص منه عن طريق ال kidney بيروح
+
+222
+00:18:00,870 --> 00:18:05,760
+على ال kidney وال kidney بتطلعه مع ال urineit is
+
+223
+00:18:05,760 --> 00:18:09,760
+level rises in the blood when obstructive jaundice
+
+224
+00:18:09,760 --> 00:18:14,660
+as from gall stones or hepatic jaundice occurs
+
+225
+00:18:14,660 --> 00:18:20,260
+كلمة or hepatic jaundice occur احذفوها إذا الجملة
+
+226
+00:18:20,260 --> 00:18:24,340
+it is level rises in the blood when obstructive
+
+227
+00:18:24,340 --> 00:18:27,950
+jaundice as from gall stonesفي هذه الجملة بيحكينا
+
+228
+00:18:27,950 --> 00:18:32,510
+إن الـ Conjugated bilirubin بزداد تركيزه في الدم
+
+229
+00:18:32,510 --> 00:18:36,710
+متى حالة مرضية، في حالة الـ Obstructive jaundice
+
+230
+00:18:36,710 --> 00:18:40,430
+إيش يعني Obstructive jaundice؟ يعني كلمة
+
+231
+00:18:40,430 --> 00:18:44,690
+Obstructive انسداد بالحصاوي، بالـ Gallstoneتخيلوا
+
+232
+00:18:44,690 --> 00:18:50,270
+معي إنه القناة الصفراوية اتكون فيها stones اتكون
+
+233
+00:18:50,270 --> 00:18:54,350
+فيها حصاوي هلجيت ال conjugated Billy Robin اتكون
+
+234
+00:18:54,350 --> 00:18:58,290
+في الكبد و بده يمشي في القناة الصفراوية عشان يروح
+
+235
+00:18:58,290 --> 00:19:02,870
+للأمعاء، تمام؟في القناة السفرية في حصاوي يعني مش
+
+236
+00:19:02,870 --> 00:19:08,230
+هيقدر يمشي ال conjugated باليروبين تمام؟ وبالتالي
+
+237
+00:19:08,230 --> 00:19:11,850
+إيش هيصير؟ إيش هيعمل؟ مش هيقدر ينزل لتحت وينزل
+
+238
+00:19:11,850 --> 00:19:15,950
+للأمعاء وبالتالي يطلع مع ال thesis فهيضلوا محجوب
+
+239
+00:19:15,950 --> 00:19:21,290
+فوق على بلازم الدم هيرجع على بلازم الدم يرجع بشكل
+
+240
+00:19:21,290 --> 00:19:26,900
+عكسي لفوق لبلازم الدم إذا موجودحثاوي في القناة
+
+241
+00:19:26,900 --> 00:19:32,540
+الصفرية هتمنع دخول الـ conjugated bilirubin عبر
+
+242
+00:19:32,540 --> 00:19:36,420
+هذه القناة هو بيمشي عبر هذه القناة عشان يصل
+
+243
+00:19:36,420 --> 00:19:40,100
+الأمعاء وبالتالي مش هيقدر يصل الأمعاء ومش هيطلع
+
+244
+00:19:40,100 --> 00:19:44,780
+برا الجسم وبالتالي هيطلع لفوق ويرجع لـ Plasma الدم
+
+245
+00:19:44,780 --> 00:19:51,230
+ويزيد تركيزههلجيت لما الـ conjugated bilirubin
+
+246
+00:19:51,230 --> 00:19:56,350
+يزيد هذه حالة مرضية يفترض يكون هو تركيزه في ال
+
+247
+00:19:56,350 --> 00:20:01,010
+plasma ده قليل جدا لكن لما بيزيد معناه أن هذه حالة
+
+248
+00:20:01,010 --> 00:20:06,360
+مرضيةIn this case, the bilirubin is unable to
+
+249
+00:20:06,360 --> 00:20:09,880
+reach the intestines في هذه الحالة، الـ bilirubin
+
+250
+00:20:09,880 --> 00:20:14,620
+مش قادر يصل الأمعاء عشان يطلع مع الـ feces for
+
+251
+00:20:14,620 --> 00:20:19,560
+excretion مش قادر and instead enter the
+
+252
+00:20:19,560 --> 00:20:23,800
+bloodstream for excretion by the kidneysعشان هيك
+
+253
+00:20:23,800 --> 00:20:27,320
+إيش بيسوي؟ بيروح بيروح على بلازمة الدم برجع
+
+254
+00:20:27,320 --> 00:20:32,700
+لبلازمة الدم وبتراكم في بلازمة الدم وما بيلاقي حل
+
+255
+00:20:32,700 --> 00:20:39,260
+إلا إنه يروح على ال kidney وال kidney اتطلعه مع ال
+
+256
+00:20:39,260 --> 00:20:44,980
+urine عشان هيك لو فحصنا ال conjugated bilirubin في
+
+257
+00:20:44,980 --> 00:20:49,240
+ال urine حنلاقيه عالي كتير كتير أعلى من الإنسان
+
+258
+00:20:49,240 --> 00:20:53,800
+الطبيعي، ليش؟لأنه أصلاً هو عالي في بلازمة الدم
+
+259
+00:20:53,800 --> 00:20:58,060
+وبالتالي هيروح على الـ kidney و الـ kidney إيش
+
+260
+00:20:58,060 --> 00:21:04,100
+هتعمل؟ هتعمله execution مع الـ urine و هيزيد
+
+261
+00:21:04,100 --> 00:21:09,830
+تركيزه أكتر في الـ urineوفي بلازمة دم Conjugated
+
+262
+00:21:09,830 --> 00:21:13,790
+bilirubin is the only type of bilirubin able to
+
+263
+00:21:13,790 --> 00:21:17,650
+cross the glomerulus filter. This it is the only
+
+264
+00:21:17,650 --> 00:21:20,770
+type of bilirubin that can be found in the urine
+
+265
+00:21:21,840 --> 00:21:25,220
+أصلا الـ Unconjugated bilirubin الـ bilirubin
+
+266
+00:21:25,220 --> 00:21:30,360
+الغير مرتبط بيطلع من الـ RBCs عطول بيطلع من تكسير
+
+267
+00:21:30,360 --> 00:21:33,500
+الـ RBCs يعني من تكسير الـ Hemoglobin و بيضل جزء
+
+268
+00:21:33,500 --> 00:21:37,240
+منه في بلازم الدم و كله بيروح على الكبد و بيتحول
+
+269
+00:21:37,240 --> 00:21:41,400
+لـ Conjugated يعني الـ Unconjugated bilirubin لا
+
+270
+00:21:41,400 --> 00:21:45,860
+بيشوف الكلة ولا بيشوف الأمعاء ولا بيطلع مع الـ
+
+271
+00:21:45,860 --> 00:21:50,570
+urine ولا بيطلع مع الـ feces تمام؟لكن النوع
+
+272
+00:21:50,570 --> 00:21:55,110
+المرتبط الـ bilirubin الـ conjugated المرتبط بيمر
+
+273
+00:21:55,110 --> 00:21:59,010
+على الأمعاق و بطلع مع الـ feces أيضًا بيمر على
+
+274
+00:21:59,010 --> 00:22:03,450
+الكدن مش حاكينا الـ uropilinogen جزء منه بيروح على
+
+275
+00:22:03,450 --> 00:22:08,070
+الكدن و بيصير له execution مع ال urine يعني ال
+
+276
+00:22:08,070 --> 00:22:12,260
+conjugated bilirubin هو النوع الوحيد اللي بيمرعلى
+
+277
+00:22:12,260 --> 00:22:18,380
+الـ kidney وبتم عمل له عملية فلترة وخروج مع الـ
+
+278
+00:22:18,380 --> 00:22:22,620
+urine لكن الـ unconjugated ما بيشوف لا kidney ولا
+
+279
+00:22:22,620 --> 00:22:29,060
+intestine كله بتحول لـ conjugatedأما النوع الآخر
+
+280
+00:22:29,060 --> 00:22:32,940
+الـ Unconjugated bilirubin الـ bilirubin الغير
+
+281
+00:22:32,940 --> 00:22:36,620
+مرتبط أو بيسموه الـ indirect bilirubin أو الـ
+
+282
+00:22:36,620 --> 00:22:39,720
+unconjugated bilirubin is normally found in the
+
+283
+00:22:39,720 --> 00:22:45,480
+bloodstream فقط أنا بشوفه في الدم بتركيز قليل جدا
+
+284
+00:22:45,480 --> 00:22:50,720
+الوضع الطبيعي Unconjugated bilirubin rises in case
+
+285
+00:22:50,720 --> 00:22:55,030
+of hemolytic jaundiceمتى بيزيد الـ Unconjugated
+
+286
+00:22:55,030 --> 00:22:59,540
+bilirubin في حالات الـ Hemolytic Anemia؟ركزوا معي
+
+287
+00:22:59,540 --> 00:23:03,640
+لما بيصير عندي homolytic anemia يعني الـ RBCs اللي
+
+288
+00:23:03,640 --> 00:23:08,340
+بتتكون و بتصل الدم بسرعة بتتكسر معناه في عندي RBC
+
+289
+00:23:08,340 --> 00:23:12,900
+بتتكسر بشكل أكبر معناه Hemoglobins هيصير له
+
+290
+00:23:12,900 --> 00:23:18,020
+release و يتكسر بشكل أكبر معناه حاصل تكسير ال
+
+291
+00:23:18,020 --> 00:23:22,500
+Hemoglobin هيطلع Unconjugated bilirubin بكميات
+
+292
+00:23:22,500 --> 00:23:27,390
+كبيرة في bloodstream في الدمالـ breakdown of
+
+293
+00:23:27,390 --> 00:23:32,110
+hemoglobin results in a higher than normal level
+
+294
+00:23:32,110 --> 00:23:36,390
+of unconjugated bilirubin being present in the
+
+295
+00:23:36,390 --> 00:23:40,110
+bloodstream اللي صار انه حالات الـ hemolytic
+
+296
+00:23:40,110 --> 00:23:46,530
+anemia حلق صعبة عند كميات كبيرة من ال RBCs بتتصنع
+
+297
+00:23:46,530 --> 00:23:51,720
+وبالتالي كلها اتتكسرأي RBCs تتصنع بسرعة بتتكسر
+
+298
+00:23:51,720 --> 00:23:56,040
+فعندي حجم هائل من الـ RBCs بتتكسر وبتطلع
+
+299
+00:23:56,040 --> 00:23:59,880
+Hemoglobin برضه الـ Hemoglobin بيتكسر وبيعطينا الـ
+
+300
+00:23:59,880 --> 00:24:04,340
+Unconjugated bilirubin بكميات أكبر من الوضع الـ
+
+301
+00:24:04,340 --> 00:24:08,100
+Normal، تمام؟ إذن الـ Unconjugated bilirubin بيزيد
+
+302
+00:24:08,100 --> 00:24:12,080
+في حالات الـ Hemolytic Anemia لكن الـ Conjugated
+
+303
+00:24:12,080 --> 00:24:16,380
+bilirubin الـ bilirubin المرتبط حكينا بيزيد في حال
+
+304
+00:24:16,750 --> 00:24:22,690
+اتكونت حصاوي في العصارة أو في القناة الصفراوية
+
+305
+00:24:22,690 --> 00:24:28,280
+تمام؟This is the type of bilirubin elevated in
+
+306
+00:24:28,280 --> 00:24:32,240
+cases of hepatocellular dysfunction such as
+
+307
+00:24:32,240 --> 00:24:36,540
+hepatitis الـ Unconjugated bilirubin بزيد في حالات
+
+308
+00:24:36,540 --> 00:24:41,600
+الـ hemolytic أنيميا وأيضا بزيد في حالة صار في
+
+309
+00:24:41,600 --> 00:24:45,640
+عنده hepatocellular dysfunction مشكلة في خلايا
+
+310
+00:24:45,640 --> 00:24:49,870
+الكبدإيش هذه المشكلة؟ مثلًا Hepatitis Hepatitis
+
+311
+00:24:49,870 --> 00:24:54,070
+معناه التهاب في خلايا الكبد بغض نظر عن سبب الاتهاب
+
+312
+00:24:54,070 --> 00:24:59,450
+فيروس كحول أيا كان خلايا الكبد حدث فيها مشكلة حدث
+
+313
+00:24:59,450 --> 00:25:05,730
+فيها damage تمام؟حلجات الـ RBCs اتكسّرت وطلعت الـ
+
+314
+00:25:05,730 --> 00:25:09,990
+Hemoglobin الـ Hemoglobin اتكسّر و أعطاني
+
+315
+00:25:09,990 --> 00:25:15,570
+Unconjugated Bilirubin أجى الألبم حمله وودّاه على
+
+316
+00:25:15,570 --> 00:25:21,720
+الكبد الكبد فيه مشكلةفي التهاب في خلاياه تمام؟
+
+317
+00:25:21,720 --> 00:25:27,000
+وبالتالي مش هيقدر الكبد يحول الـ Unconjugated
+
+318
+00:25:27,000 --> 00:25:31,340
+bilirubin لconjugated bilirubin وبالتالي إيش اللي
+
+319
+00:25:31,340 --> 00:25:34,700
+هيصير؟ إيش متوقعين يصير؟ متوقعين إن الـ
+
+320
+00:25:34,700 --> 00:25:39,860
+Unconjugated bilirubin هيزيد تركيزه في بلازمة الدم
+
+321
+00:25:39,860 --> 00:25:44,910
+لإن الكبد في خلل، في مشكلةمش جادر يحوله مش جادر
+
+322
+00:25:44,910 --> 00:25:50,110
+يربطه بمادة الـglucuronic acid ويحوله ل conjugated
+
+323
+00:25:50,110 --> 00:25:55,030
+bilirubin إذا الـunconjugated bilirubin بيزداد في
+
+324
+00:25:55,030 --> 00:25:59,190
+حالة الـhemolytic أنيميا وحالات الـHepatitis،
+
+325
+00:25:59,190 --> 00:26:04,540
+تمام؟هنا عملنا جدول فرجلنا بين الـ bilirubin
+
+326
+00:26:04,540 --> 00:26:09,120
+المرتبط بمادة الـglucuronic acid والـ bilirubin
+
+327
+00:26:09,120 --> 00:26:13,560
+الغير مرتبط اللي بيطلع بسرعة من الـ hemoglobin
+
+328
+00:26:13,560 --> 00:26:18,020
+المتكسر تمام؟ ال conjugated bilirubin، الـ
+
+329
+00:26:18,020 --> 00:26:21,930
+bilirubin المرتبط بيسموه الـ directبلي روبن البلي
+
+330
+00:26:21,930 --> 00:26:26,130
+روبن المباشر الصفة التانية له انه water soluble
+
+331
+00:26:26,130 --> 00:26:30,750
+دائب في الميه يعني دائب في بلازمة دم يعني بيمشي في
+
+332
+00:26:30,750 --> 00:26:35,730
+بلازمة دم من غير اي carrier من غير اي ناقل تمام
+
+333
+00:26:35,730 --> 00:26:41,770
+found in urine بشوفه في ال urine لأن جزء منه بيروح
+
+334
+00:26:41,770 --> 00:26:45,770
+على الكلاق وبالتالي بيصير له execution عن طريق ال
+
+335
+00:26:45,770 --> 00:26:53,500
+urineبصيرله execution عن طريق الكدنى وبالتالي
+
+336
+00:26:53,500 --> 00:27:02,060
+بيطلع مع الـ urine مابتدوش أي محفز أثناء التفاعل،
+
+337
+00:27:02,060 --> 00:27:05,880
+هذه هنشوفها أكتر إشي في التفاعل يعني مابدوه في الـ
+
+338
+00:27:05,880 --> 00:27:10,000
+kit الخاص في ورّي أيجينت تبع الـ conjugated Billy
+
+339
+00:27:10,000 --> 00:27:16,000
+Robin مابيكون فيه أي محفز لشغلهأما الـ Bilirubin
+
+340
+00:27:16,000 --> 00:27:20,960
+الغير مرتبط أو بيسموه غير مباشر هو water insoluble
+
+341
+00:27:20,960 --> 00:27:25,000
+غير دائب في الميه يعني غير دائب في بلازمة الدم لما
+
+342
+00:27:25,000 --> 00:27:29,120
+طلع من ال RBCs يعني طلع من ال hemoglobin اللي
+
+343
+00:27:29,120 --> 00:27:34,180
+موجود جواهات ال RBCs طلع وصل بلازمة الدم لما راح
+
+344
+00:27:34,180 --> 00:27:38,760
+على الكبت حكينا إجا ال album اللي نقله ال album
+
+345
+00:27:38,760 --> 00:27:43,340
+عبارة عن ال protein بشتغل ك transporter ناقلبنقل
+
+346
+00:27:43,340 --> 00:27:49,420
+الـ Unconjugated bilirubin من الدم إلى الكبد Not
+
+347
+00:27:49,420 --> 00:27:53,100
+found in urine تفاجنا لا بشوفه في urine ولا بشوفه
+
+348
+00:27:53,100 --> 00:27:57,560
+في feces تمام؟ needs accelerator يعني أثناء
+
+349
+00:27:57,560 --> 00:28:03,160
+التفاعل وفي ال reaction نحتاج إلى محفزالـ Total
+
+350
+00:28:03,160 --> 00:28:06,620
+Bilirubin الـ kit أنا لما بحكيلكوا بدنا نفحص Total
+
+351
+00:28:06,620 --> 00:28:12,780
+Bilirubin معناه الـ kit هذا بيحسبلي ال conjugated
+
+352
+00:28:12,780 --> 00:28:16,660
+bilirubin زائد ال unconjugated bilirubin يعني
+
+353
+00:28:16,660 --> 00:28:20,760
+بيحسبلي كل ال bilirubin اللي موجود في بلازم الدم
+
+354
+00:28:20,760 --> 00:28:25,380
+سواء المرتبط أو الغير مرتبط يعني conjugated زائد
+
+355
+00:28:25,380 --> 00:28:29,200
+unconjugated bilirubin typically only the total
+
+356
+00:28:29,200 --> 00:28:33,640
+bilirubin is reported عادة يا جماعةالدكتور بطلب
+
+357
+00:28:33,640 --> 00:28:38,800
+الـ Total Billy-Robin وبنسجل نتيجته لكن لو لاحظ
+
+358
+00:28:38,800 --> 00:28:42,300
+الدكتور إنه فيه مشكلة في الـ Total Billy-Robin
+
+359
+00:28:42,300 --> 00:28:46,780
+مثلًا الـ Total Billy-Robin عالي، تمام؟ ساعتها
+
+360
+00:28:46,780 --> 00:28:50,990
+بطلبالـ Direct والـ Indirect باللي روبن ساعتها
+
+361
+00:28:50,990 --> 00:28:55,410
+بيطلب فحص الأنواع الإتنين عشان يعرف وين المشكلة
+
+362
+00:28:55,410 --> 00:28:59,170
+بالظبط المشكلة في ال Direct باللي روبن ولا ال
+
+363
+00:28:59,170 --> 00:29:02,730
+Indirect باللي روبن مين اللي فيه مشكلة ومين اللي
+
+364
+00:29:02,730 --> 00:29:07,110
+زايد تمام؟إذا كان الفحص الـ Total بيه مشكلة إذا
+
+365
+00:29:07,110 --> 00:29:12,350
+كان الفحص الـ Total بيه مشكلة تجارب تجارب تجارب
+
+366
+00:29:12,350 --> 00:29:13,970
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+367
+00:29:13,970 --> 00:29:15,330
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+368
+00:29:15,330 --> 00:29:16,930
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+369
+00:29:16,930 --> 00:29:17,210
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+370
+00:29:17,210 --> 00:29:17,370
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+371
+00:29:17,370 --> 00:29:22,290
+تجارب تجارب تجارب تجارب تجارب تجفحص الـ Direct
+
+372
+00:29:22,290 --> 00:29:27,090
+والـ Indirect الفحصين اعملهم على حدة نشوف وين
+
+373
+00:29:27,090 --> 00:29:30,150
+المشكلة بالظبط يعني بدنا نفهم ان ال Direct بلي
+
+374
+00:29:30,150 --> 00:29:36,530
+روبن له kit وال Indirect بلي روبن أيضا له kitممكن
+
+375
+00:29:36,530 --> 00:29:40,270
+أنا أقيس الـ Total Billy-Robin بالـ kit الخاص فيه
+
+376
+00:29:40,270 --> 00:29:45,710
+و أطرحه و أعمل فحص ال conjugated بس و أطرحه من ال
+
+377
+00:29:45,710 --> 00:29:49,210
+conjugated بتطلعلي تركيز ال unconjugated Billy
+
+378
+00:29:49,210 --> 00:29:52,570
+-Robin أو العكس Total Billy-Robin ناقص ال
+
+379
+00:29:52,570 --> 00:29:56,990
+unconjugated بتطلعلي ال conjugated يعني ممكن أعمل
+
+380
+00:29:56,990 --> 00:30:00,690
+ال total Billy-Robin و أعمل واحد من الاتنين و
+
+381
+00:30:00,690 --> 00:30:06,200
+بطرحه من بعض بتطلعلي التالت واضح؟لـ Clinical
+
+382
+00:30:06,200 --> 00:30:11,220
+Significance أهمية الفحص حالات بيزيد فيها الـ
+
+383
+00:30:11,220 --> 00:30:14,720
+Conjugated bilirubin الحالة الأولى حكيناها الـ
+
+384
+00:30:14,720 --> 00:30:18,700
+Biliary Obstruction انسداد في الـ Biliary Duct في
+
+385
+00:30:18,700 --> 00:30:23,080
+القناع الصفراوية هلجيت الـ Conjugated bilirubin
+
+386
+00:30:23,080 --> 00:30:28,130
+اتكول فيه الكبتوبدّه يصيرله Execration حكينا بيمر
+
+387
+00:30:28,130 --> 00:30:32,090
+عبر القناة الصفرية بعدين بروح على الأمعاق عشان
+
+388
+00:30:32,090 --> 00:30:36,450
+يطلع مع الـ stool لكن لو لاجى Stones حصاوي في هذه
+
+389
+00:30:36,450 --> 00:30:40,870
+القناة مش هيقدر يمشي فيها وبالتالي هيرجع بشكل
+
+390
+00:30:40,870 --> 00:30:46,010
+reverse على الكبد مرة أخرى وبعدين هيطلع على إبلازم
+
+391
+00:30:46,010 --> 00:30:51,590
+الدم ويزيد تركيزه في الدم، تمام؟الحالة التانية
+
+392
+00:30:51,590 --> 00:30:56,010
+Cancer of the head of the pancreas حدوث سرطان في
+
+393
+00:30:56,010 --> 00:31:01,970
+أعلى البنكرياس لو جينا تخيلنا التركيبة الكبد تحت
+
+394
+00:31:01,970 --> 00:31:06,550
+المرارة زي ما تذكرين جنب الكبد بسرعة البنكرياس أو
+
+395
+00:31:06,550 --> 00:31:12,360
+لتحته شويةهل جاد الـ liver والأمعاء إيش اللي بيوصل
+
+396
+00:31:12,360 --> 00:31:16,440
+بينهم؟ الـ bilary duct القناة الصفراوية كذلك
+
+397
+00:31:16,440 --> 00:31:22,200
+البنكرياس والأمعاء إيش بيوصل بينهم؟ برضه الـ
+
+398
+00:31:22,200 --> 00:31:25,800
+bilary duct برضه القناة الصفراوية لأنه يا جماعة
+
+399
+00:31:25,800 --> 00:31:31,190
+البنكرياس مش بس بيفرز هرمونات زي الإنسلينبرضه الـ
+
+400
+00:31:31,190 --> 00:31:37,410
+Pancreas بيفرذ أميلاز و ليباز هذه أنزيمات بيفرذها
+
+401
+00:31:37,410 --> 00:31:41,990
+الـ Pancreas و بتمشي عبر القناة الصفراوية و بتروح
+
+402
+00:31:41,990 --> 00:31:46,230
+على الأمعاء عشان تساعد في هضم الطعام تساعد في هضم
+
+403
+00:31:46,230 --> 00:31:50,750
+الـ ليباز بيساعد في هضم الدهون الـ Amylase بيساعد
+
+404
+00:31:50,750 --> 00:31:56,860
+في هضم الـ Carbohydrate تمام؟ وبالتاليلما بيصير
+
+405
+00:31:56,860 --> 00:32:01,920
+عند الـ Cancer بالـ Pancreas معنى الكلام ممكن الـ
+
+406
+00:32:01,920 --> 00:32:06,300
+Cancer يمد على الـ Biliary Duct يعني ممكن يصيرله
+
+407
+00:32:06,300 --> 00:32:11,990
+Metastasis ينتشر ويمد ويصيب القناة الصفراويةفلما
+
+408
+00:32:11,990 --> 00:32:17,190
+بيصير عندي cancer في القناة الصفراوية برضه هتتأثر
+
+409
+00:32:17,190 --> 00:32:21,610
+القناة وبالتالي الـ conjugated دليروبين اللي اتكون
+
+410
+00:32:21,610 --> 00:32:28,210
+فيه الكبد مش هيقدر يمشي عبر هذه القناة لأن خلايا
+
+411
+00:32:28,210 --> 00:32:34,280
+هذه القناة ضربتومش هيقدر يمشي من خلال القناة
+
+412
+00:32:34,280 --> 00:32:38,600
+السفرية ويروح على الأمعاء وبالتالي هيضل فيه الكبد
+
+413
+00:32:38,600 --> 00:32:43,640
+ويرجع على بلازمة الدم ويزيد تركيزه إذا سرطان في
+
+414
+00:32:43,640 --> 00:32:48,020
+الـ pancreas ممكن يمد هذا السرطان على القناة
+
+415
+00:32:48,020 --> 00:32:51,880
+السفرية اللي هيمشي فيها الـ conjugated bilirubin
+
+416
+00:32:51,880 --> 00:32:56,140
+فلو صار في القناةCancer معناه مش هيقدر الـ
+
+417
+00:32:56,140 --> 00:32:59,000
+conjugated bilirubin يعبر ويروح على الأمعاق
+
+418
+00:32:59,000 --> 00:33:03,020
+وبالتالي هيزداد تركيزه في الدم حالات الدوبين
+
+419
+00:33:03,020 --> 00:33:07,680
+جونسون سيندروم هذه syndrome يعني أكيد مرض وراثي
+
+420
+00:33:07,680 --> 00:33:12,060
+هذا المرض الوراثي معناه أنه أنا بيصير في عندى
+
+421
+00:33:12,060 --> 00:33:18,170
+مشكلة في الـBiliary duct تمام؟مشكلة وراثية في
+
+422
+00:33:18,170 --> 00:33:21,950
+القناة الصفراوية بيصير فيها obstruction بيصير فيها
+
+423
+00:33:21,950 --> 00:33:26,670
+incident سبب الincident مش حصاوي إنما هو وراثي
+
+424
+00:33:26,670 --> 00:33:30,050
+يعني مثلا ممكن الشخص ينولد عنده القناة الصفراوية
+
+425
+00:33:30,050 --> 00:33:34,190
+مغلقة مش فاتحة تمام؟ وبالتالي بيجي ال conjugated
+
+426
+00:33:34,190 --> 00:33:37,850
+بلي روبين اتكون فيه الكبد بده يطلع عبر هذا القناة
+
+427
+00:33:37,850 --> 00:33:42,620
+بيلاجيهامغلقة هذه الـ Syndrome بنسميها Dopine
+
+428
+00:33:42,620 --> 00:33:49,040
+Johnson Syndrome حدوث غلق في القدم بشكل وراسي
+
+429
+00:33:49,040 --> 00:33:54,590
+تمام؟أما الـ Unconjugated Billy Robin ماتة بالزيد
+
+430
+00:33:54,590 --> 00:33:58,770
+يا جماعة أول حالة حكنها Autoimmune Hemolysis يعني
+
+431
+00:33:58,770 --> 00:34:03,990
+Hemolytic Anemia لما بيصير عنده ال RBCs بتعرف
+
+432
+00:34:03,990 --> 00:34:08,030
+عليها الجسم كأنها خلايا غريبة وبالتالي بيطلعلها
+
+433
+00:34:08,030 --> 00:34:12,490
+Antibody بهجمها بتتكسر وبالتالي بيطلعله مجلبا و
+
+434
+00:34:12,490 --> 00:34:16,670
+بتكسرونتيجة تكسير الـ Hemoglobin بتطلع الـ
+
+435
+00:34:16,670 --> 00:34:20,070
+Unconjugated bilirubin طبعا Hemolytic Anemia يعني
+
+436
+00:34:20,070 --> 00:34:25,290
+تكسير مهول في الـ RBCs يعني هيطلع Unconjugated
+
+437
+00:34:25,290 --> 00:34:33,240
+bilirubin بكميات كبيرة، تمام؟حالات الكريجلر نجار
+
+438
+00:34:33,240 --> 00:34:39,520
+سيندروم كريجلر نجار سيندروم هذه مرض وراسي بيصير في
+
+439
+00:34:39,520 --> 00:34:45,420
+عندي طفرة في الجين المسئول عن تصنيع الـ enzyme
+
+440
+00:34:45,420 --> 00:34:49,820
+اللي مسئول عن الـ conjugation مش حاكينا في الكبد
+
+441
+00:34:50,730 --> 00:34:54,930
+بيجي الـ Unconjugated bilirubin عشان يتحول عشان
+
+442
+00:34:54,930 --> 00:35:00,110
+يتم ربطه بالـ Glucuronic Acid هلجيت حكينا مين بربط
+
+443
+00:35:00,110 --> 00:35:03,210
+الـ Unconjugated bilirubin بالـ Glucuronic Acid؟
+
+444
+00:35:03,210 --> 00:35:07,930
+حكينا فيه Enzyme موجود في الكبد لكن لو هذا الإنسان
+
+445
+00:35:07,930 --> 00:35:11,850
+عنده Crigler Najjar Syndrome يعني مش هيتم تصنيع
+
+446
+00:35:11,850 --> 00:35:17,490
+هذا الـ Enzyme في الكبد بسبب مشكلة ورثيةبالتالي مش
+
+447
+00:35:17,490 --> 00:35:22,290
+هيصير ارتباط للـ Unconjugated bilirubin مش هيتم
+
+448
+00:35:22,290 --> 00:35:25,870
+ربطه بالـ Glucuronic Acid وبالتالي إيش المحصلة؟ إن
+
+449
+00:35:25,870 --> 00:35:30,110
+الـ Unconjugated bilirubin هيظل عالي في بلازمة دم
+
+450
+00:35:30,110 --> 00:35:32,830
+على الفاضي هييجي على الكبد على الفاضي الكبد مش
+
+451
+00:35:32,830 --> 00:35:38,290
+هيقدر يعمل ربط لأنه مافيش إنزايم جواته يعمل هذا
+
+452
+00:35:38,290 --> 00:35:43,680
+الربط حالات الـ Gilbert Syndromeالـ Gilbert
+
+453
+00:35:43,680 --> 00:35:47,760
+Syndrome اللي جات الـ Unconjugated بيلي روبن طلع
+
+454
+00:35:47,760 --> 00:35:52,720
+من الـ RBCs مين الـ carrier له، مين اللي حمله على
+
+455
+00:35:52,720 --> 00:35:56,780
+الكبت حكينا الألبما، هذا ناقل للـ Unconjugated
+
+456
+00:35:56,780 --> 00:36:02,010
+بيلي روبن لأنه ما بيقدر يمشي في بلازمة دهانحملهم
+
+457
+00:36:02,010 --> 00:36:06,090
+وبالتالي وراحوا علي الكبد هلجيت قبل ما يفوتوا
+
+458
+00:36:06,090 --> 00:36:10,310
+الكبد يا جماعة؟ فيه Receptor على سطح الكبد تمام؟
+
+459
+00:36:10,310 --> 00:36:14,650
+هذا الـReceptor الـUnconjugated Billy-Robin برتبط
+
+460
+00:36:14,650 --> 00:36:18,370
+عليها وبعدين الكبد بيسحب الـUnconjugated Billy
+
+461
+00:36:18,370 --> 00:36:21,690
+-Robin للداخل لكن الناس اللي عندهم Gilbert
+
+462
+00:36:21,690 --> 00:36:27,460
+Syndromeبكون عندهم بشكل وراسي مشكلة في الـ
+
+463
+00:36:27,460 --> 00:36:31,540
+Receptor اللي موجودة على سطح الكبت اللي بدي يرتبط
+
+464
+00:36:31,540 --> 00:36:35,580
+فيها الـ Unconjugated bilirubin عشان يدخل لجوا
+
+465
+00:36:35,580 --> 00:36:39,600
+الكبت عشان هيك في حالات الـ Gilbert Syndrome أصلا
+
+466
+00:36:39,600 --> 00:36:42,720
+الـ Unconjugated bilirubin مقدرش يفوت جوا الكبت
+
+467
+00:36:42,720 --> 00:36:47,000
+فهيضلوا فيه بلازمة دم عالي حالات الـ Hemolytic
+
+468
+00:36:47,000 --> 00:36:50,840
+Transfusion Reaction يعني عمليات نجلة الدم، في ناس
+
+469
+00:36:50,840 --> 00:36:54,430
+كتير بنقولولهم الدمبعد فترة بيصير عندهم Hemolysis
+
+470
+00:36:54,430 --> 00:37:00,670
+أو نجلناله دم فصيلة غير فصيلته، تمام؟ المحصلة
+
+471
+00:37:00,670 --> 00:37:04,790
+هيصير في تكسير للـRBCs بكميات أكبر، يعني تكسير
+
+472
+00:37:04,790 --> 00:37:08,710
+للـHemoglobin، يعني خروج الـUnconjugated bilirubin
+
+473
+00:37:08,710 --> 00:37:14,490
+بشكل مهول من الـRBCs حالات الـHepatitis، اتفجنالما
+
+474
+00:37:14,490 --> 00:37:18,570
+خلايا الكبد يكون فيها مشكلة، يكون فيها التهاب بيجي
+
+475
+00:37:18,570 --> 00:37:22,330
+الـ Unconjugated bilirubin بده يتحول لـ Conjugated
+
+476
+00:37:22,330 --> 00:37:26,150
+bilirubin، خلايا الكبد ماتقدر يتحولوا لأنه فيها
+
+477
+00:37:26,150 --> 00:37:31,310
+مشكلة المحصلة إن الـ Unconjugated bilirubin تركيزه
+
+478
+00:37:31,310 --> 00:37:36,810
+بارتفاع في الدم، تمام؟طبعًا يا جماعة التفسير إن
+
+479
+00:37:36,810 --> 00:37:41,970
+هذه الـ Syndrome إيش هي هذا الكلام لأ مش هتضبكوا
+
+480
+00:37:41,970 --> 00:37:47,870
+فيه فقط للمعرفة بس إن الحالات المهمة هذه يعني بدنا
+
+481
+00:37:47,870 --> 00:37:50,630
+نعرف إيش الحالات اللي بيزيد فيها الـ Conjugated و
+
+482
+00:37:50,630 --> 00:37:53,690
+الحالات اللي بيزيد فيها الـ Unconjugated ومش ضروري
+
+483
+00:37:53,690 --> 00:37:57,150
+التفسير اللي أنا شرحته فقط للعلم، تمام؟
+
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/8z-8bV0QAco_raw.json b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/8z-8bV0QAco_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..ba31c989d2beab3b63f355651db3e89f0a0c0eef
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/8z-8bV0QAco_raw.json
@@ -0,0 +1 @@
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السفرية وبتمشي عبر قناة اسمها الـ Biliary Duct اللي هي قناة العصارة السفرية بتمشي من الكبد وبتروح على الأمعاء عشان تساعد في هضم الدهون أيضًا الـ Execration of bile خروج هذه العصارة من الكبد", "tokens": [5172, 14407, 24401, 3660, 9154, 4032, 19913, 16373, 5172, 2423, 39184, 28010, 9673, 16095, 3660, 36145, 3224, 4724, 25957, 1211, 17662, 2405, 24976, 39184, 363, 794, 5097, 327, 24976, 3615, 9381, 9640, 3660, 21136, 5172, 2288, 10632, 4032, 3555, 39237, 8592, 1829, 6225, 26890, 12174, 8315, 3660, 24525, 2304, 11296, 2423, 39184, 363, 38550, 5153, 349, 13672, 1829, 39896, 12174, 8315, 3660, 18863, 9381, 9640, 3660, 21136, 5172, 2288, 10632, 4724, 39237, 8592, 1829, 9154, 33251, 44510, 46599, 2655, 32887, 5016, 15844, 16247, 2304, 3615, 16606, 6225, 8592, 7649, 6055, 3794, 995, 22488, 8978, 8032, 11242, 2304, 32748, 3224, 11536, 36632, 11242, 14111, 995, 2423, 39184, 17662, 2405, 295, 18729, 16490, 2288, 29245, 29538, 18863, 9381, 9640, 3660, 9154, 33251, 44510], "avg_logprob": 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"ممكن يصير فيه أحيانًا الـproblem ويصير فيه مشكلة في عملية الـexecration لهذه العصارة السفرية، تمام؟", "tokens": [2304, 43020, 7251, 9381, 13546, 8978, 3224, 5551, 5016, 1829, 7649, 14111, 995, 2423, 39184, 47419, 4032, 1829, 9381, 13546, 8978, 3224, 37893, 28820, 3660, 8978, 6225, 42213, 10632, 2423, 39184, 3121, 3045, 2405, 46740, 24192, 18863, 9381, 9640, 3660, 21136, 5172, 2288, 10632, 12399, 46811, 10943, 22807], "avg_logprob": -0.16964285227717185, "compression_ratio": 1.2651515151515151, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 83.33, "end": 83.87, "word": "ممكن", "probability": 0.94775390625}, {"start": 83.87, "end": 84.39, "word": " يصير", "probability": 0.9641927083333334}, {"start": 84.39, "end": 84.59, "word": " فيه", "probability": 0.964599609375}, {"start": 84.59, "end": 85.25, "word": " أحيانًا", "probability": 0.8912353515625}, {"start": 85.25, "end": 85.99, "word": " الـproblem", "probability": 0.5068359375}, {"start": 85.99, "end": 86.63, "word": 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bile salt عبارة عن bile pigments and others يعني هي عصارة سفروية ومن اسمها سفروية يعني في مادة كيميائية تعطيها اللون الأصفر تعطيها دي", "tokens": [33, 794, 16802, 3598, 18729, 21667, 420, 50191, 4724, 1829, 5016, 4117, 1829, 20292, 36145, 3224, 18863, 9381, 9640, 3660, 21136, 5172, 2288, 2407, 10632, 35186, 4724, 1829, 38251, 2407, 11296, 18729, 8258, 34051, 18729, 5139, 6225, 3555, 9640, 3660, 18871, 13412, 2407, 22807, 39894, 2655, 30544, 9154, 13412, 2407, 29538, 2423, 18729, 8258, 4032, 2423, 18729, 5139, 6225, 3555, 9640, 3660, 18871, 18729, 8120, 1117, 293, 2357, 37495, 22653, 39896, 6225, 9381, 9640, 3660, 8608, 5172, 32887, 10632, 4032, 27842, 24525, 2304, 11296, 8608, 5172, 32887, 10632, 37495, 22653, 8978, 3714, 18513, 3660, 9122, 32640, 1829, 16373, 10632, 37279, 9566, 1829, 11296, 13672, 11536, 16247, 9381, 5172, 2288, 37279, 9566, 1829, 11296, 11778, 1829], "avg_logprob": -0.1342941807775662, "compression_ratio": 1.8275862068965518, "no_speech_prob": 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Conjugated", "probability": 0.8681640625}, {"start": 723.81, "end": 724.95, "word": " bilirubin", "probability": 0.9871826171875}, {"start": 724.95, "end": 726.19, "word": " تمام؟", "probability": 0.7255859375}, {"start": 726.19, "end": 726.59, "word": " هالجيت", "probability": 0.7752685546875}, {"start": 726.59, "end": 727.25, "word": " الكابت", "probability": 0.8984375}, {"start": 727.25, "end": 728.71, "word": " هياخد", "probability": 0.8837890625}, {"start": 728.71, "end": 729.51, "word": " جزء", "probability": 0.95947265625}, {"start": 729.51, "end": 730.35, "word": " بسيط", "probability": 0.99755859375}, {"start": 730.35, "end": 730.89, "word": " من", "probability": 0.97021484375}, {"start": 730.89, "end": 731.33, "word": " هذا", "probability": 0.85302734375}, {"start": 731.33, "end": 731.59, "word": " الـ", "probability": 0.90673828125}, {"start": 731.59, "end": 732.41, "word": " Conjugated", "probability": 0.9383138020833334}, {"start": 732.41, "end": 733.39, "word": " 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"probability": 0.92236328125}, {"start": 740.23, "end": 740.75, "word": " بلازمة", "probability": 0.93994140625}, {"start": 740.75, "end": 741.07, "word": " الدم", "probability": 0.991943359375}], "temperature": 1.0}, {"id": 34, "seek": 75381, "start": 741.21, "end": 753.81, "text": "في عيننا الـ Unconjugated bilirubin والـ Conjugated bilirubin يعني أنه عين موجودين في بلازم الدم وبتراكيز قليلة هذا الوضع الطبيعي تمام؟", "tokens": [41185, 6225, 9957, 8315, 2423, 39184, 1156, 1671, 42068, 770, 8588, 347, 836, 259, 16070, 39184, 2656, 42068, 770, 8588, 347, 836, 259, 37495, 22653, 14739, 3224, 6225, 9957, 3714, 29245, 23328, 9957, 8978, 4724, 1211, 31377, 2304, 32748, 2304, 46599, 2655, 23557, 4117, 1829, 11622, 12174, 20292, 37977, 23758, 2423, 2407, 11242, 3615, 41950, 21292, 3615, 1829, 46811, 10943, 22807], "avg_logprob": -0.16872479333992926, "compression_ratio": 1.390728476821192, "no_speech_prob": 3.635883331298828e-06, "words": [{"start": 741.21, "end": 741.69, "word": "في", 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"probability": 0.8662109375}, {"start": 749.11, "end": 749.61, "word": " بلازم", "probability": 0.8194580078125}, {"start": 749.61, "end": 749.93, "word": " الدم", "probability": 0.915283203125}, {"start": 749.93, "end": 751.15, "word": " وبتراكيز", "probability": 0.8741861979166666}, {"start": 751.15, "end": 751.65, "word": " قليلة", "probability": 0.9324544270833334}, {"start": 751.65, "end": 751.95, "word": " هذا", "probability": 0.53564453125}, {"start": 751.95, "end": 752.51, "word": " الوضع", "probability": 0.9942626953125}, {"start": 752.51, "end": 753.19, "word": " الطبيعي", "probability": 0.987548828125}, {"start": 753.19, "end": 753.81, "word": " تمام؟", "probability": 0.8248697916666666}], "temperature": 1.0}, {"id": 35, "seek": 77322, "start": 755.24, "end": 773.22, "text": "تمام طيب الـ conjugated bilirubin حكينا جزء بسيط بواسطة الكبت و شرينه أو ردته تم إيصاله لبلازمة الدم طيب الجزء الكبير اللي ضايل ال conjugated bilirubin وين بدي يروح الجسم بده يتخلص منه؟", "tokens": 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{"start": 1231.58, "end": 1232.2, "word": " بيلاقي", "probability": 0.8197021484375}, {"start": 1232.2, "end": 1232.7, "word": " حل", "probability": 0.989990234375}, {"start": 1232.7, "end": 1233.34, "word": " إلا", "probability": 0.9677734375}, {"start": 1233.34, "end": 1233.84, "word": " إنه", "probability": 0.794189453125}, {"start": 1233.84, "end": 1234.3, "word": " يروح", "probability": 0.9928385416666666}, {"start": 1234.3, "end": 1234.76, "word": " على", "probability": 0.9423828125}, {"start": 1234.76, "end": 1235.34, "word": " ال", "probability": 0.8662109375}, {"start": 1235.34, "end": 1235.82, "word": " kidney", "probability": 0.50830078125}, {"start": 1235.82, "end": 1236.44, "word": " وال", "probability": 0.64013671875}, {"start": 1236.44, "end": 1237.08, "word": " kidney", "probability": 0.9423828125}, {"start": 1237.08, "end": 1238.32, "word": " اتطلعه", "probability": 0.8909505208333334}, {"start": 1238.32, "end": 1238.82, "word": " مع", "probability": 0.98583984375}, {"start": 1238.82, "end": 1239.26, "word": " ال", "probability": 0.9658203125}, {"start": 1239.26, "end": 1239.58, "word": " urine", "probability": 0.95263671875}, {"start": 1239.58, "end": 1240.42, "word": " عشان", "probability": 0.98828125}, {"start": 1240.42, "end": 1241.18, "word": " هيك", "probability": 0.9951171875}, {"start": 1241.18, "end": 1241.34, "word": " لو", "probability": 0.9169921875}, {"start": 1241.34, "end": 1242.02, "word": " فحصنا", "probability": 0.9793701171875}, {"start": 1242.02, "end": 1242.58, "word": " ال", "probability": 0.982421875}, {"start": 1242.58, "end": 1243.56, "word": " conjugated", "probability": 0.896484375}, {"start": 1243.56, "end": 1244.78, "word": " bilirubin", "probability": 0.853271484375}, {"start": 1244.78, "end": 1244.98, "word": " في", "probability": 0.96142578125}, {"start": 1244.98, "end": 1245.12, "word": " ال", "probability": 0.9853515625}, {"start": 1245.12, "end": 1245.44, "word": " urine", "probability": 0.9892578125}, {"start": 1245.44, "end": 1246.66, "word": " حنلاقيه", "probability": 0.708642578125}, {"start": 1246.66, "end": 1247.22, "word": " عالي", "probability": 0.97998046875}, {"start": 1247.22, "end": 1247.54, "word": " كتير", "probability": 0.9759114583333334}, {"start": 1247.54, "end": 1248.0, "word": " كتير", "probability": 0.9700520833333334}, {"start": 1248.0, "end": 1248.48, "word": " أعلى", "probability": 0.8732096354166666}, {"start": 1248.48, "end": 1248.64, "word": " من", "probability": 0.99658203125}, {"start": 1248.64, "end": 1249.24, "word": " الإنسان", "probability": 0.9927978515625}, {"start": 1249.24, "end": 1249.88, "word": " الطبيعي،", "probability": 0.90126953125}, {"start": 1249.88, "end": 1250.32, "word": " ليش؟", "probability": 0.9710286458333334}], "temperature": 1.0}, {"id": 58, "seek": 126626, "start": 1250.62, "end": 1266.26, "text": "لأنه أصلاً هو عالي في بلازمة الدم وبالتالي هيروح على الـ kidney و الـ kidney إيش هتعمل؟ هتعمله execution مع الـ urine و هيزيد تركيزه أكتر في الـ urine", "tokens": [1211, 33456, 3224, 5551, 9381, 15040, 14111, 31439, 6225, 6027, 1829, 8978, 4724, 1211, 31377, 46007, 32748, 2304, 46599, 6027, 2655, 6027, 1829, 39896, 32887, 5016, 15844, 2423, 39184, 19000, 4032, 2423, 39184, 19000, 11933, 1829, 8592, 8032, 2655, 25957, 1211, 22807, 8032, 2655, 25957, 43761, 15058, 20449, 2423, 39184, 27638, 4032, 39896, 11622, 25708, 6055, 31747, 1829, 11622, 3224, 5551, 4117, 2655, 2288, 8978, 2423, 39184, 27638], "avg_logprob": -0.1699501872062683, "compression_ratio": 1.5157232704402517, "no_speech_prob": 0.0, "words": [{"start": 1250.62, "end": 1251.28, "word": "لأنه", "probability": 0.9285481770833334}, {"start": 1251.28, "end": 1251.82, "word": " أصلاً", "probability": 0.8638916015625}, {"start": 1251.82, "end": 1252.06, "word": " هو", "probability": 0.7841796875}, {"start": 1252.06, "end": 1252.58, "word": " عالي", "probability": 0.9723307291666666}, {"start": 1252.58, "end": 1252.76, "word": " في", "probability": 0.91455078125}, 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This it is the only type of bilirubin that can be found in the urine", "tokens": [2407, 41185, 4724, 1211, 31377, 46007, 11778, 2304, 2656, 42068, 770, 8588, 347, 836, 259, 307, 264, 787, 2010, 295, 8588, 347, 836, 259, 1075, 281, 3278, 264, 1563, 14301, 26107, 6608, 13, 639, 309, 307, 264, 787, 2010, 295, 8588, 347, 836, 259, 300, 393, 312, 1352, 294, 264, 27638], "avg_logprob": -0.19996995507524565, "compression_ratio": 1.3507462686567164, "no_speech_prob": 0.0, "words": [{"start": 1267.07, "end": 1267.39, "word": "وفي", "probability": 0.775390625}, {"start": 1267.39, "end": 1267.95, "word": " بلازمة", "probability": 0.57293701171875}, {"start": 1267.95, "end": 1268.29, "word": " دم", "probability": 0.4857177734375}, {"start": 1268.29, "end": 1269.83, "word": " Conjugated", "probability": 0.703857421875}, {"start": 1269.83, "end": 1270.59, "word": " bilirubin", "probability": 0.935302734375}, {"start": 1270.59, "end": 1271.01, "word": " is", "probability": 0.8671875}, {"start": 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{"start": 1276.41, "end": 1276.75, "word": " it", "probability": 0.7587890625}, {"start": 1276.75, "end": 1277.01, "word": " is", "probability": 0.94921875}, {"start": 1277.01, "end": 1277.31, "word": " the", "probability": 0.908203125}, {"start": 1277.31, "end": 1277.65, "word": " only", "probability": 0.9248046875}, {"start": 1277.65, "end": 1278.07, "word": " type", "probability": 0.9833984375}, {"start": 1278.07, "end": 1278.37, "word": " of", "probability": 0.97509765625}, {"start": 1278.37, "end": 1278.97, "word": " bilirubin", "probability": 0.9869384765625}, {"start": 1278.97, "end": 1279.25, "word": " that", "probability": 0.94189453125}, {"start": 1279.25, "end": 1279.47, "word": " can", "probability": 0.9541015625}, {"start": 1279.47, "end": 1279.67, "word": " be", "probability": 0.95166015625}, {"start": 1279.67, "end": 1280.07, "word": " found", "probability": 0.91455078125}, {"start": 1280.07, "end": 1280.39, "word": " in", "probability": 0.95654296875}, {"start": 1280.39, "end": 1280.53, "word": " the", "probability": 0.5908203125}, {"start": 1280.53, "end": 1280.77, "word": " urine", "probability": 0.97998046875}], "temperature": 1.0}, {"id": 60, "seek": 130858, "start": 1281.84, "end": 1308.58, "text": "أصلا الـ Unconjugated bilirubin الـ bilirubin الغير مرتبط بيطلع من الـ RBCs عطول بيطلع من تكسير الـ RBCs يعني من تكسير الـ Hemoglobin و بيضل جزء منه في بلازم الدم و كله بيروح على الكبد و بيتحول لـ Conjugated يعني الـ Unconjugated bilirubin لا بيشوف الكلة ولا بيشوف الأمعاء ولا بيطلع مع الـ urine ولا بيطلع مع الـ feces تمام؟", "tokens": [10721, 9381, 15040, 2423, 39184, 1156, 1671, 42068, 770, 8588, 347, 836, 259, 2423, 39184, 8588, 347, 836, 259, 6024, 118, 13546, 3714, 43500, 3555, 9566, 4724, 1829, 9566, 1211, 3615, 9154, 2423, 39184, 497, 7869, 82, 6225, 9566, 12610, 4724, 1829, 9566, 1211, 3615, 9154, 6055, 4117, 3794, 13546, 2423, 39184, 497, 7869, 82, 37495, 22653, 9154, 6055, 4117, 3794, 13546, 2423, 39184, 18568, 45841, 13496, 4032, 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يعني ال conjugated bilirubin هو النوع الوحيد اللي بيمر", "tokens": [1211, 19452, 28239, 45367, 9673, 43500, 3555, 9566, 2423, 39184, 8588, 347, 836, 259, 2423, 39184, 29456, 770, 9673, 43500, 3555, 9566, 4724, 32640, 2288, 15844, 16247, 2304, 3615, 995, 4587, 4032, 4724, 9566, 1211, 3615, 20449, 2423, 39184, 579, 887, 36632, 11242, 14111, 995, 4724, 32640, 2288, 15844, 33251, 3215, 1863, 37893, 11331, 995, 4117, 1829, 8315, 2423, 39184, 344, 1513, 388, 259, 8799, 10874, 11622, 38207, 9154, 3224, 4724, 13546, 2407, 5016, 15844, 33251, 3215, 1863, 4032, 4724, 1829, 9381, 13546, 46740, 15058, 20449, 2423, 27638, 37495, 22653, 2423, 29456, 770, 8588, 347, 836, 259, 31439, 28239, 45367, 2423, 2407, 5016, 25708, 13672, 1829, 4724, 32640, 2288], "avg_logprob": -0.16747159483757887, "compression_ratio": 1.8523809523809525, "no_speech_prob": 5.364418029785156e-07, "words": [{"start": 1309.21, "end": 1309.83, "word": "لكن", "probability": 0.91796875}, {"start": 1309.83, "end": 1310.57, "word": " 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bilirubin being present in the bloodstream اللي صار انه حالات الـ hemolytic anemia حلق صعبة عند كميات كبيرة من ال RBCs بتتصنع وبالتالي كلها اتتكسر", "tokens": [6027, 39184, 18188, 295, 8636, 45841, 13496, 3542, 294, 257, 2946, 813, 2710, 1496, 295, 35847, 42068, 770, 8588, 347, 836, 259, 885, 1974, 294, 264, 3390, 9291, 13672, 1829, 20328, 9640, 16472, 3224, 11331, 6027, 9307, 2423, 39184, 8636, 16453, 40907, 364, 14058, 11331, 1211, 4587, 20328, 3615, 49401, 43242, 9122, 2304, 1829, 9307, 9122, 3555, 48923, 9154, 2423, 497, 7869, 82, 39894, 2655, 9381, 1863, 3615, 46599, 6027, 2655, 6027, 1829, 28242, 11296, 1975, 2655, 2655, 4117, 3794, 2288], "avg_logprob": -0.24676067636507312, "compression_ratio": 1.35, "no_speech_prob": 0.0, "words": [{"start": 1406.07, "end": 1406.29, "word": "الـ", "probability": 0.4111328125}, {"start": 1406.29, "end": 1406.79, "word": " breakdown", "probability": 0.39013671875}, {"start": 1406.79, "end": 1407.39, "word": " of", "probability": 0.51025390625}, 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1451.3, "end": 1452.08, "word": " Conjugated", "probability": 0.9296875}, {"start": 1452.08, "end": 1452.86, "word": " bilirubin", "probability": 0.9588623046875}, {"start": 1452.86, "end": 1453.34, "word": " الـ", "probability": 0.6456298828125}, {"start": 1453.34, "end": 1453.9, "word": " bilirubin", "probability": 0.8818359375}, {"start": 1453.9, "end": 1454.58, "word": " المرتبط", "probability": 0.9794921875}, {"start": 1454.58, "end": 1455.1, "word": " حكينا", "probability": 0.9534912109375}, {"start": 1455.1, "end": 1455.72, "word": " بيزيد", "probability": 0.9749755859375}, {"start": 1455.72, "end": 1455.92, "word": " في", "probability": 0.99072265625}, {"start": 1455.92, "end": 1456.38, "word": " حال", "probability": 0.99462890625}], "temperature": 1.0}, {"id": 68, "seek": 146353, "start": 1456.75, "end": 1463.53, "text": "اتكونت حصاوي في العصارة أو في القناة الصفراوية تمام؟", "tokens": [9307, 30544, 2655, 11331, 9381, 995, 45865, 8978, 18863, 9381, 9640, 3660, 34051, 8978, 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"seek": 148608, "start": 1464.66, "end": 1486.08, "text": "This is the type of bilirubin elevated in cases of hepatocellular dysfunction such as hepatitis الـ Unconjugated bilirubin بزيد في حالات الـ hemolytic أنيميا وأيضا بزيد في حالة صار في عنده hepatocellular dysfunction مشكلة في خلايا الكبد", "tokens": [5723, 307, 264, 2010, 295, 8588, 347, 836, 259, 23457, 294, 3331, 295, 26299, 2513, 4164, 1040, 32002, 1270, 382, 48372, 16074, 2423, 39184, 1156, 1671, 42068, 770, 8588, 347, 836, 259, 4724, 11622, 25708, 8978, 11331, 6027, 9307, 2423, 39184, 8636, 16453, 40907, 14739, 32640, 25528, 36725, 1829, 11242, 995, 4724, 11622, 25708, 8978, 11331, 6027, 3660, 20328, 9640, 8978, 43242, 3224, 26299, 2513, 4164, 1040, 32002, 37893, 28820, 3660, 8978, 16490, 15040, 25528, 33251, 44510], "avg_logprob": -0.18619791246377504, "compression_ratio": 1.5463917525773196, "no_speech_prob": 5.364418029785156e-07, "words": [{"start": 1464.66, "end": 1465.04, "word": "This", "probability": 0.30908203125}, 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{"start": 1471.76, "end": 1472.24, "word": " as", "probability": 0.98486328125}, {"start": 1472.24, "end": 1473.06, "word": " hepatitis", "probability": 0.774658203125}, {"start": 1473.06, "end": 1474.0, "word": " الـ", "probability": 0.608642578125}, {"start": 1474.0, "end": 1474.78, "word": " Unconjugated", "probability": 0.77618408203125}, {"start": 1474.78, "end": 1475.5, "word": " bilirubin", "probability": 0.951904296875}, {"start": 1475.5, "end": 1476.06, "word": " بزيد", "probability": 0.7646484375}, {"start": 1476.06, "end": 1476.18, "word": " في", "probability": 0.95068359375}, {"start": 1476.18, "end": 1476.54, "word": " حالات", "probability": 0.97216796875}, {"start": 1476.54, "end": 1476.7, "word": " الـ", "probability": 0.89208984375}, {"start": 1476.7, "end": 1477.3, "word": " hemolytic", "probability": 0.7257486979166666}, {"start": 1477.3, "end": 1478.04, "word": " أنيميا", "probability": 0.56982421875}, {"start": 1478.04, "end": 1478.92, "word": " وأيضا", 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"word": " الكبد", "probability": 0.725341796875}, {"start": 1517.21, "end": 1517.57, "word": " فيه", "probability": 0.834228515625}, {"start": 1517.57, "end": 1518.13, "word": " مشكلة", "probability": 0.9860026041666666}], "temperature": 1.0}, {"id": 72, "seek": 154256, "start": 1518.7, "end": 1542.56, "text": "في التهاب في خلاياه تمام؟ وبالتالي مش هيقدر الكبد يحول الـ Unconjugated bilirubin لconjugated bilirubin وبالتالي إيش اللي هيصير؟ إيش متوقعين يصير؟ متوقعين إن الـ Unconjugated bilirubin هيزيد تركيزه في بلازمة الدم لإن الكبد في خلل، في مشكلة", "tokens": [41185, 16712, 11296, 3555, 8978, 16490, 15040, 25528, 3224, 46811, 10943, 22807, 46599, 6027, 2655, 6027, 1829, 37893, 39896, 28543, 2288, 33251, 44510, 7251, 5016, 12610, 2423, 39184, 1156, 1671, 42068, 770, 8588, 347, 836, 259, 5296, 1671, 42068, 770, 8588, 347, 836, 259, 46599, 6027, 2655, 6027, 1829, 11933, 1829, 8592, 13672, 1829, 39896, 9381, 13546, 22807, 11933, 1829, 8592, 44650, 30543, 3615, 9957, 7251, 9381, 13546, 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1522.64, "end": 1523.44, "word": " هيقدر", "probability": 0.9679361979166666}, {"start": 1523.44, "end": 1524.16, "word": " الكبد", "probability": 0.6700439453125}, {"start": 1524.16, "end": 1525.36, "word": " يحول", "probability": 0.93701171875}, {"start": 1525.36, "end": 1525.98, "word": " الـ", "probability": 0.935302734375}, {"start": 1525.98, "end": 1527.0, "word": " Unconjugated", "probability": 0.83135986328125}, {"start": 1527.0, "end": 1527.82, "word": " bilirubin", "probability": 0.886474609375}, {"start": 1527.82, "end": 1529.52, "word": " لconjugated", "probability": 0.761383056640625}, {"start": 1529.52, "end": 1530.34, "word": " bilirubin", "probability": 0.9893798828125}, {"start": 1530.34, "end": 1531.04, "word": " وبالتالي", "probability": 0.93876953125}, {"start": 1531.04, "end": 1531.22, "word": " إيش", "probability": 0.8611653645833334}, {"start": 1531.22, "end": 1531.34, "word": " اللي", "probability": 0.9697265625}, {"start": 1531.34, "end": 1531.82, "word": " هيصير؟", "probability": 0.809326171875}, {"start": 1531.82, "end": 1531.92, "word": " إيش", "probability": 0.9617513020833334}, {"start": 1531.92, "end": 1532.42, "word": " متوقعين", "probability": 0.9727783203125}, {"start": 1532.42, "end": 1533.34, "word": " يصير؟", "probability": 0.9830322265625}, {"start": 1533.34, "end": 1534.0, "word": " متوقعين", "probability": 0.9798583984375}, {"start": 1534.0, "end": 1534.3, "word": " إن", "probability": 0.66357421875}, {"start": 1534.3, "end": 1534.7, "word": " الـ", "probability": 0.94189453125}, {"start": 1534.7, "end": 1535.76, "word": " Unconjugated", "probability": 0.9549560546875}, {"start": 1535.76, "end": 1536.64, "word": " bilirubin", "probability": 0.986083984375}, {"start": 1536.64, "end": 1537.56, "word": " هيزيد", "probability": 0.8880208333333334}, {"start": 1537.56, "end": 1538.4, "word": " تركيزه", "probability": 0.9919921875}, {"start": 1538.4, "end": 1538.56, "word": " في", "probability": 0.95849609375}, {"start": 1538.56, "end": 1539.26, "word": " بلازمة", "probability": 0.82958984375}, {"start": 1539.26, "end": 1539.86, "word": " الدم", "probability": 0.9833984375}, {"start": 1539.86, "end": 1540.5, "word": " لإن", "probability": 0.7833658854166666}, {"start": 1540.5, "end": 1540.92, "word": " الكبد", "probability": 0.93408203125}, {"start": 1540.92, "end": 1541.16, "word": " في", "probability": 0.98828125}, {"start": 1541.16, "end": 1541.82, "word": " خلل،", "probability": 0.8880615234375}, {"start": 1541.82, "end": 1541.92, "word": " في", "probability": 0.9677734375}, {"start": 1541.92, "end": 1542.56, "word": " مشكلة", "probability": 0.9892578125}], "temperature": 1.0}, {"id": 73, "seek": 155975, "start": 1542.59, "end": 1559.75, "text": "مش جادر يحوله مش جادر يربطه بمادة الـglucuronic acid ويحوله ل conjugated bilirubin إذا الـunconjugated bilirubin بيزداد في حالة الـhemolytic أنيميا وحالات الـHepatitis، تمام؟", "tokens": [2304, 8592, 10874, 18513, 2288, 7251, 5016, 12610, 3224, 37893, 10874, 18513, 2288, 7251, 25513, 9566, 3224, 4724, 15042, 41891, 2423, 39184, 7191, 1311, 374, 11630, 8258, 4032, 1829, 5016, 12610, 3224, 5296, 29456, 770, 8588, 347, 836, 259, 11933, 15730, 2423, 39184, 409, 1671, 42068, 770, 8588, 347, 836, 259, 4724, 1829, 11622, 3215, 18513, 8978, 11331, 6027, 3660, 2423, 39184, 28005, 16453, 40907, 14739, 32640, 25528, 4032, 5016, 6027, 9307, 2423, 39184, 39, 595, 267, 16074, 12399, 46811, 10943, 22807], "avg_logprob": -0.1937123486794621, "compression_ratio": 1.4795321637426901, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 1542.59, "end": 1543.07, "word": "مش", "probability": 0.9453125}, {"start": 1543.07, "end": 1543.57, "word": " جادر", "probability": 0.8605143229166666}, {"start": 1543.57, "end": 1544.11, "word": " يحوله", "probability": 0.8731689453125}, {"start": 1544.11, "end": 1544.35, "word": " مش", "probability": 0.457275390625}, {"start": 1544.35, "end": 1544.91, "word": " جادر", "probability": 0.9527994791666666}, {"start": 1544.91, "end": 1545.57, "word": " يربطه", "probability": 0.970458984375}, {"start": 1545.57, "end": 1546.33, "word": " بمادة", "probability": 0.8811848958333334}, {"start": 1546.33, "end": 1547.39, "word": " الـglucuronic", "probability": 0.7952067057291666}, {"start": 1547.39, "end": 1547.89, "word": " acid", "probability": 0.91357421875}, {"start": 1547.89, "end": 1548.93, "word": " ويحوله", "probability": 0.93271484375}, {"start": 1548.93, "end": 1549.23, "word": " ل", "probability": 0.9189453125}, {"start": 1549.23, "end": 1550.11, "word": " conjugated", "probability": 0.692626953125}, {"start": 1550.11, "end": 1550.91, "word": " bilirubin", "probability": 0.9388427734375}, {"start": 1550.91, "end": 1551.67, "word": " إذا", "probability": 0.4759521484375}, {"start": 1551.67, "end": 1553.05, "word": " الـunconjugated", "probability": 0.8050944010416666}, {"start": 1553.05, "end": 1553.91, "word": " bilirubin", "probability": 0.981689453125}, {"start": 1553.91, "end": 1554.85, "word": " بيزداد", "probability": 0.9158203125}, {"start": 1554.85, "end": 1555.03, "word": " في", "probability": 0.94189453125}, {"start": 1555.03, "end": 1555.49, "word": " حالة", "probability": 0.9972330729166666}, {"start": 1555.49, "end": 1556.23, "word": " الـhemolytic", "probability": 0.82060546875}, {"start": 1556.23, "end": 1556.91, "word": " أنيميا", "probability": 0.6590983072916666}, {"start": 1556.91, "end": 1557.95, "word": " وحالات", "probability": 0.968505859375}, {"start": 1557.95, "end": 1559.19, "word": " الـHepatitis،", "probability": 0.7599051339285714}, {"start": 1559.19, "end": 1559.75, "word": " تمام؟", "probability": 0.9757486979166666}], "temperature": 1.0}, {"id": 74, "seek": 158068, "start": 1561.1, "end": 1580.68, "text": "هنا عملنا جدول فرجلنا بين الـ bilirubin المرتبط بمادة الـglucuronic acid والـ bilirubin الغير مرتبط اللي بيطلع بسرعة من الـ hemoglobin المتكسر تمام؟ ال conjugated bilirubin، الـ bilirubin المرتبط بيسموه الـ direct", "tokens": [3224, 8315, 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"word": " فرجلنا", "probability": 0.873779296875}, {"start": 1563.34, "end": 1563.6, "word": " بين", "probability": 0.9814453125}, {"start": 1563.6, "end": 1564.0, "word": " الـ", "probability": 0.86083984375}, {"start": 1564.0, "end": 1564.54, "word": " bilirubin", "probability": 0.78765869140625}, {"start": 1564.54, "end": 1565.44, "word": " المرتبط", "probability": 0.98486328125}, {"start": 1565.44, "end": 1566.3, "word": " بمادة", "probability": 0.9313151041666666}, {"start": 1566.3, "end": 1567.3, "word": " الـglucuronic", "probability": 0.753631591796875}, {"start": 1567.3, "end": 1567.82, "word": " acid", "probability": 0.8828125}, {"start": 1567.82, "end": 1568.48, "word": " والـ", "probability": 0.4219970703125}, {"start": 1568.48, "end": 1569.12, "word": " bilirubin", "probability": 0.9888916015625}, {"start": 1569.12, "end": 1569.84, "word": " الغير", "probability": 0.8880208333333334}, {"start": 1569.84, "end": 1570.42, "word": " مرتبط", "probability": 0.9947509765625}, {"start": 1570.42, "end": 1570.72, "word": " اللي", "probability": 0.90283203125}, {"start": 1570.72, "end": 1571.4, "word": " بيطلع", "probability": 0.9716796875}, {"start": 1571.4, "end": 1572.2, "word": " بسرعة", "probability": 0.9866943359375}, {"start": 1572.2, "end": 1572.54, "word": " من", "probability": 0.98974609375}, {"start": 1572.54, "end": 1572.98, "word": " الـ", "probability": 0.7076416015625}, {"start": 1572.98, "end": 1573.56, "word": " hemoglobin", "probability": 0.7957356770833334}, {"start": 1573.56, "end": 1574.66, "word": " المتكسر", "probability": 0.93828125}, {"start": 1574.66, "end": 1576.2, "word": " تمام؟", "probability": 0.6824544270833334}, {"start": 1576.2, "end": 1576.3, "word": " ال", "probability": 0.966796875}, {"start": 1576.3, "end": 1577.02, "word": " conjugated", "probability": 0.698486328125}, {"start": 1577.02, "end": 1577.8, "word": " bilirubin،", "probability": 0.852685546875}, {"start": 1577.8, "end": 1578.02, "word": " الـ", "probability": 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{"start": 2254.45, "end": 2254.59, "word": " يا", "probability": 0.84228515625}, {"start": 2254.59, "end": 2255.05, "word": " جماعة", "probability": 0.9921875}, {"start": 2255.05, "end": 2256.43, "word": " التفسير", "probability": 0.9632161458333334}, {"start": 2256.43, "end": 2256.81, "word": " إن", "probability": 0.5380859375}, {"start": 2256.81, "end": 2257.11, "word": " هذه", "probability": 0.240234375}, {"start": 2257.11, "end": 2257.29, "word": " الـ", "probability": 0.804443359375}, {"start": 2257.29, "end": 2257.71, "word": " Syndrome", "probability": 0.4052734375}, {"start": 2257.71, "end": 2258.67, "word": " إيش", "probability": 0.8463541666666666}, {"start": 2258.67, "end": 2259.05, "word": " هي", "probability": 0.9462890625}, {"start": 2259.05, "end": 2260.37, "word": " هذا", "probability": 0.60009765625}, {"start": 2260.37, "end": 2260.83, "word": " الكلام", "probability": 0.9690755208333334}, {"start": 2260.83, "end": 2261.23, "word": " لأ", "probability": 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"end": 2277.15, "word": " تمام؟", "probability": 0.9765625}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2278.3651875, "duration_after_vad": 2243.453124999995}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/8z-8bV0QAco_raw.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/8z-8bV0QAco_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..38eebe3c490617d4fc06c34aac864a5dbf92ca52
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/8z-8bV0QAco_raw.srt
@@ -0,0 +1,1936 @@
+1
+00:00:01,030 --> 00:00:04,290
+السلام عليكم ورحمة الله وبركاته يعطيكم العافية
+
+2
+00:00:04,290 --> 00:00:08,030
+جميعا ان شاء الله اليوم محاضرتنا بعنوان Billy
+
+3
+00:00:08,030 --> 00:00:09,270
+Robin Test
+
+4
+00:00:11,590 --> 00:00:15,170
+one of the most important liver functions and one
+
+5
+00:00:15,170 --> 00:00:18,930
+that is distributed in a large number of diseases
+
+6
+00:00:18,930 --> 00:00:24,910
+is the excretion of bile بيحكيلي واحدة من أهم
+
+7
+00:00:24,910 --> 00:00:29,530
+الوظائف اللي بيشتغل فيها ال liver ويمكن حكيناها
+
+8
+00:00:29,530 --> 00:00:33,370
+المعمل اللي فات انه مسئول عن تصنيع ال bile acid
+
+9
+00:00:33,370 --> 00:00:38,550
+العصارة السفراوية والعصارة السفراوية حكينا بتساعد
+
+10
+00:00:38,550 --> 00:00:43,770
+ال liver بعد ما يكونهابعمللها execution بيوديها
+
+11
+00:00:43,770 --> 00:00:49,470
+وبتنتقل عبر القناة الصفرية للأمعاء عشان هناك الـ
+
+12
+00:00:49,470 --> 00:00:55,610
+bile acid بيتساعد في هضم الدهون، تمام؟فواحدة من
+
+13
+00:00:55,610 --> 00:01:02,310
+وظائف الـ Liver المهمة إنه بعمل Execration للـ
+
+14
+00:01:02,310 --> 00:01:07,190
+Bile Acid للعصارة السفرية وبتمشي عبر قناة اسمها
+
+15
+00:01:07,190 --> 00:01:11,730
+الـ Biliary Duct اللي هي قناة العصارة السفرية
+
+16
+00:01:11,730 --> 00:01:15,950
+بتمشي من الكبد وبتروح على الأمعاء عشان تساعد في
+
+17
+00:01:15,950 --> 00:01:21,450
+هضم الدهون أيضًا الـ Execration of bile خروج هذه
+
+18
+00:01:21,450 --> 00:01:25,990
+العصارة من الكبدممكن يصير فيه أحيانًا الـproblem
+
+19
+00:01:25,990 --> 00:01:30,430
+ويصير فيه مشكلة في عملية الـexecration لهذه
+
+20
+00:01:30,430 --> 00:01:37,390
+العصارة السفرية، تمام؟Bile comprises bile acids or
+
+21
+00:01:37,390 --> 00:01:41,830
+salts بيحكيلي إنه العصارة السفروية يا بيسموها bile
+
+22
+00:01:41,830 --> 00:01:46,890
+acid أو bile salt عبارة عن شو؟ بتتكون من شو هذه ال
+
+23
+00:01:46,890 --> 00:01:50,610
+bile acid و ال bile salt عبارة عن bile pigments
+
+24
+00:01:50,610 --> 00:01:55,110
+and others يعني هي عصارة سفروية ومن اسمها سفروية
+
+25
+00:01:55,110 --> 00:02:00,590
+يعني في مادة كيميائية تعطيها اللون الأصفر تعطيها
+
+26
+00:02:00,590 --> 00:02:05,760
+ديالعصارة السفرية اللون الأصفر تمام؟ هنشوف شو هي
+
+27
+00:02:05,760 --> 00:02:10,320
+المادة بالي روبين is the principal pigment in the
+
+28
+00:02:10,320 --> 00:02:15,180
+bile ال بالي روبين هذه المادة الكيميائية هي اللي
+
+29
+00:02:15,180 --> 00:02:20,620
+بتعطي العصارة السفرية اللون اليلو اللون الأصفر
+
+30
+00:02:20,620 --> 00:02:26,700
+تمام؟بلي روبن derived from breakdown of hemoglobin
+
+31
+00:02:26,700 --> 00:02:30,900
+بلي روبن من وين جاي؟ جاي من تكسير ال hemoglobin
+
+32
+00:02:30,900 --> 00:02:36,160
+هلجيت يا جماعة ال RBCs جديش عمرها 120 يوم كل 120
+
+33
+00:02:36,160 --> 00:02:40,180
+يوم ال RBCs بتتكسر و بتطلع بدالها لما بتتكسر ال
+
+34
+00:02:40,180 --> 00:02:44,600
+RBCs بتطلع ال hemoglobin منها أيضا ال hemoglobin
+
+35
+00:02:44,600 --> 00:02:49,060
+هو بروتين له عمر معين له half-life معين أيضا
+
+36
+00:02:49,060 --> 00:02:53,770
+بيتكسرلمّا بتكسّر الـ Hemoglobin كلكم عارفين،
+
+37
+00:02:53,770 --> 00:02:58,330
+بعطيني الـ Hem-group الـ Hem-group و الـ Globin
+
+38
+00:02:58,330 --> 00:03:04,390
+-group أيضًا الـ Hem-group لما يتكسّر حاصل تكسير
+
+39
+00:03:04,390 --> 00:03:09,050
+الـ Hem-group تتكون عند مادة الـ Bilirubin يعني لو
+
+40
+00:03:09,050 --> 00:03:13,190
+سألناكوا المادة الكيميائية الـ Bilirubin من وين
+
+41
+00:03:13,190 --> 00:03:17,510
+جاية؟ جاية من تكسير الـ Hem اللي موجود في الـ
+
+42
+00:03:17,510 --> 00:03:21,360
+Hemoglobinبس إحنا تجاوزاً ع السريع بنحكي جاية من
+
+43
+00:03:21,360 --> 00:03:25,780
+تكسير الـ Hemoglobin، تمام؟ إذا في هاي الـ slide
+
+44
+00:03:25,780 --> 00:03:29,540
+يعني معلومات عامة بس أنا بدي أركز إن الـBilly
+
+45
+00:03:29,540 --> 00:03:33,800
+Robin جاية من تكسير الـHemoglobin اللي موجود في
+
+46
+00:03:33,800 --> 00:03:38,440
+الـRBCs وتكسير بالظبط إيش الـHeme Group، تمام؟
+
+47
+00:03:41,770 --> 00:03:48,390
+بيلي روبن هناك نوعين من البيلي روبن من هذه المادة
+
+48
+00:03:48,390 --> 00:03:52,150
+الكيميائية النوع الأول بيسموه conjugated أو
+
+49
+00:03:52,150 --> 00:03:57,590
+indirect بيلي روبن البيلي روبن المرتبط أما النوع
+
+50
+00:03:57,590 --> 00:04:02,030
+الآخر هو ال unconjugated بيلي روبن أو بيسموه
+
+51
+00:04:02,030 --> 00:04:08,180
+indirect بيلي روبن هو البيلي روبن الغير مرتبطtotal
+
+52
+00:04:08,180 --> 00:04:12,040
+bilirubin is composed of the conjugated bilirubin
+
+53
+00:04:12,040 --> 00:04:15,760
+plus the unconjugated bilirubin يعني لما أحكيلك
+
+54
+00:04:15,760 --> 00:04:20,340
+اعمليلي فحص ال total bilirubin في الدم يعني بدك
+
+55
+00:04:20,340 --> 00:04:24,820
+تحسبي ال unconjugated bilirubin ال bilirubin الغير
+
+56
+00:04:24,820 --> 00:04:30,080
+مرتبط زائد ال conjugated bilirubin ال bilirubin
+
+57
+00:04:30,080 --> 00:04:35,140
+المرتبط تجمعيهم مع بعض بتطلعلك ال total bilirubin
+
+58
+00:04:35,140 --> 00:04:41,860
+ككل تمام؟هلجيت شو الفرج بين النوعين؟ والتانين
+
+59
+00:04:41,860 --> 00:04:48,160
+بيكونوا موجودين في بلازمة الدم النوع المرتبط
+
+60
+00:04:48,160 --> 00:04:54,980
+والنوع الغير مرتبط هلجيت لو جينا مع بعض نشوف كل
+
+61
+00:04:54,980 --> 00:04:58,780
+نوع وين بلاجيه؟هل جيت يا جماعة كلكوا عارفين إن
+
+62
+00:04:58,780 --> 00:05:05,220
+الـRBCs عمرها 120 يوم وبعد 120 يوم بتتكسر لما
+
+63
+00:05:05,220 --> 00:05:09,140
+بتتكسر الـRBCs بتطلع منها الـHemoglobin أيضا
+
+64
+00:05:09,140 --> 00:05:13,660
+الـHemoglobin بيتكسر حاصل تكسير الـHemoglobin
+
+65
+00:05:13,660 --> 00:05:18,280
+بعطيني Billy Robin طب هذا الـBilly Robin إيش نوعه
+
+66
+00:05:18,280 --> 00:05:22,670
+اللي جاي من تكسير الـHemoglobin؟نوعه Unconjugated
+
+67
+00:05:22,670 --> 00:05:26,830
+bilirubin بيلي روبين غير مرتبط يعني لو سألناكم
+
+68
+00:05:26,830 --> 00:05:31,450
+سؤال شو نوع الـ bilirubin اللي جاي من تكسير الـ
+
+69
+00:05:31,450 --> 00:05:37,480
+Hemoglobinواللي بالأخص جاي من تكسير الـ hemagroup
+
+70
+00:05:37,480 --> 00:05:41,840
+اللي موجودة في الـ Hemoglobin هتحكولي نوعه Billy
+
+71
+00:05:41,840 --> 00:05:46,520
+Robin غير مرتبط Unconjugated Billy Robin هلجيت لما
+
+72
+00:05:46,520 --> 00:05:50,820
+اتكسرت الـ RBCs و اتكسر الـ Hemoglobin وطلع الـ
+
+73
+00:05:50,820 --> 00:05:54,740
+Unconjugated Billy Robinعلى الدم هذا الـ
+
+74
+00:05:54,740 --> 00:05:58,100
+Unconjugated bilirubin الـ bilirubin غير مرتبط هذا
+
+75
+00:05:58,100 --> 00:06:02,900
+خطير جدا ممنوع يظل في الدم زي و زي الأمونيا إذا
+
+76
+00:06:02,900 --> 00:06:07,420
+بتتذكروا المعمل اللي فات تمام فمادة الأمونيا سامة
+
+77
+00:06:07,420 --> 00:06:12,880
+أيضا مادة الـ Unconjugated bilirubin سام ليش؟ لأن
+
+78
+00:06:12,880 --> 00:06:17,820
+هذه المادة ممكن تخترق غشاء الدماغ وتفوت على الدماغ
+
+79
+00:06:17,820 --> 00:06:22,110
+وتعمل مشاكل وممكن تؤدي إلى الوفاةلو ارتفع الـ
+
+80
+00:06:22,110 --> 00:06:26,210
+Unconjugated Billy Robin في الدم عشان هيك يا جماعة
+
+81
+00:06:27,060 --> 00:06:31,320
+الـ Unconjugated bilirubin موجود في بلازمة الدم
+
+82
+00:06:31,320 --> 00:06:36,520
+ولكن بتركيز قليل جدا تمام؟ at very very low
+
+83
+00:06:36,520 --> 00:06:41,400
+concentration طيب كيف الجسم بتخلص؟ بما أنه سامل
+
+84
+00:06:41,400 --> 00:06:45,660
+الدم و سامل الدماغ يفترض الجسم يتخلص منه هذا الـ
+
+85
+00:06:45,660 --> 00:06:50,440
+Unconjugated bilirubin طيب كيف الجسم بتخلص منه؟
+
+86
+00:06:50,440 --> 00:06:57,100
+بيروح على الكبد وفي الكبديتم التخلص من الـ
+
+87
+00:06:57,100 --> 00:07:01,740
+Unconjugated bilirubin هو بيظل جزء منه موجود في
+
+88
+00:07:01,740 --> 00:07:08,080
+بلازم الدم ولكن بتركيز قليلة جدا أما الكمية الأكبر
+
+89
+00:07:08,080 --> 00:07:11,920
+لازم الجسم يتخلص منها ومين بتخلص من الـ
+
+90
+00:07:11,920 --> 00:07:17,840
+Unconjugated bilirubin هو الكبد، تمام؟تمام نشوف
+
+91
+00:07:17,840 --> 00:07:21,920
+النقطة التالتة الـ Total bilirubin level increases
+
+92
+00:07:21,920 --> 00:07:26,300
+with any type of jaundice كلنا بنسمع بيه مرض
+
+93
+00:07:26,300 --> 00:07:32,480
+الصفار تمام بيكون الشخص وجهه أصفر أصفر ممكن يتطور
+
+94
+00:07:32,480 --> 00:07:37,000
+الوضع العينين عنده تكون صفرة كتير المنطقة البيضة
+
+95
+00:07:37,000 --> 00:07:40,800
+اللي في العين بتكون صفرة كتير هذا بيسميه صفار لما
+
+96
+00:07:40,800 --> 00:07:45,760
+الإنسان نحكي عنده صفارمعناه لو فحصتله الـ total
+
+97
+00:07:45,760 --> 00:07:52,560
+بيلي روبين عنده هيكون عالي كتير تمام؟ هنودح هذه
+
+98
+00:07:52,560 --> 00:07:56,740
+الجملة في الفقرات التانية أو في الـ slides التانية
+
+99
+00:07:56,740 --> 00:08:03,080
+تمام؟ الـ metabolism of بيلي روبين نشوف بالظبط كيف
+
+100
+00:08:03,080 --> 00:08:07,580
+الـ Billy Robin بتكون و أين بيروح و كيف بيه الجسم
+
+101
+00:08:07,580 --> 00:08:14,700
+بتخلص منه لأنه مادة ثمة تمام؟أول إشي حكينا إنه
+
+102
+00:08:14,700 --> 00:08:19,360
+تابعوا معايا على الـ Chart فوق في المربع هذا
+
+103
+00:08:19,360 --> 00:08:23,080
+المكان في الـ reticuloendothelial system في
+
+104
+00:08:23,080 --> 00:08:29,260
+الأماكن اللي بيصير فيها تكسير للـ RBCs لما بيخلص
+
+105
+00:08:29,260 --> 00:08:34,980
+عمرها إذا اتفجنا إن الـ RBCs عمرها 120 يوملما
+
+106
+00:08:34,980 --> 00:08:40,040
+بتخلص عمرها تتكسر بيصير release لالهيموجلوبين
+
+107
+00:08:40,040 --> 00:08:44,160
+بيطلع الهيموجلوبين منها الهيموجلوبين أيضا بتكسر
+
+108
+00:08:44,160 --> 00:08:49,960
+لهيم و Globin اجروا الهيم حكينا برضه بيتكسر الهيم
+
+109
+00:08:49,960 --> 00:08:56,080
+اللي بيتكسر نتيجة تكسير الهيم تتكون عندى مادة الـ
+
+110
+00:08:56,080 --> 00:09:00,960
+Unconjugated bilirubin الـ bilirubin الغير مرتبط
+
+111
+00:09:01,910 --> 00:09:06,330
+هلجيت بعد ما يتكون أو يطلع الـUnconjugated
+
+112
+00:09:06,330 --> 00:09:12,090
+bilirubin من الهيم، من حاصل تكسير الهيم، بيروح على
+
+113
+00:09:12,090 --> 00:09:17,410
+بلازمة الدم. اتفجنا إنه في البلازمة ممنوع
+
+114
+00:09:17,410 --> 00:09:21,670
+الـUnconjugated bilirubin يكون بتركيز عالي، لأن
+
+115
+00:09:21,670 --> 00:09:26,410
+مادة دسم ما ممكن تخترق غشاء الدماغ، وبتأدي إلى
+
+116
+00:09:26,410 --> 00:09:31,600
+الوفاة، وجوده.فهو موجود في بلازمة الدم في الوضع
+
+117
+00:09:31,600 --> 00:09:35,980
+الطبيعي at very low concentration بتركيز قليل جدا
+
+118
+00:09:35,980 --> 00:09:42,000
+عشان هيك الجسم بده يتخلص من الـ Unconjugated
+
+119
+00:09:42,000 --> 00:09:46,930
+bilirubin كيف؟للأسف الـ Unconjugated bilirubin هذا
+
+120
+00:09:46,930 --> 00:09:51,110
+زي و زي الدهون Insoluble في بلازمة الدم، بقدرش
+
+121
+00:09:51,110 --> 00:09:55,390
+يمشي غير دائب في بلازمة الدم، بقدرش يمشي في
+
+122
+00:09:55,390 --> 00:10:00,440
+البلازمة لحاله، بده career، بده ناقلفبيجي عند الـ
+
+123
+00:10:00,440 --> 00:10:05,260
+Albumin عبارة عن بروتين ناقل للـ Unconjugated
+
+124
+00:10:05,260 --> 00:10:10,040
+bilirubin بيحمل الـ Unconjugated bilirubin من الـ
+
+125
+00:10:10,040 --> 00:10:14,100
+plasma الدم إلى الـ liver إلى الكبت تبعه على الـ
+
+126
+00:10:14,100 --> 00:10:19,000
+chart خطوة خطوة، تمام؟إذن الـ Unconjugated
+
+127
+00:10:19,000 --> 00:10:24,000
+bilirubin معظمه وصل للـ liver وضال تركيز قليل منه
+
+128
+00:10:24,000 --> 00:10:28,600
+موجود في إبلازم الدم وهذا الوضع الطبيعي هلجت في
+
+129
+00:10:28,600 --> 00:10:34,420
+الكبد الـ Unconjugated bilirubin لازم أحوله لمادة
+
+130
+00:10:34,420 --> 00:10:39,620
+يعني تكون أقل سمية منه الـ Unconjugated bilirubin
+
+131
+00:10:39,620 --> 00:10:46,420
+بدو يتحول في الكبد لمادة أخرىهذه المادة الأخرى أقل
+
+132
+00:10:46,420 --> 00:10:50,080
+سمية من الـ Unconjugated bilirubin وبعد ذلك هذه
+
+133
+00:10:50,080 --> 00:10:55,340
+المادة الجسم بستطيع أن يتخلص منها بكل سهولة ففي
+
+134
+00:10:55,340 --> 00:10:59,320
+الكبد يوجد هناك أنزين مش بالضرورة نعرف اسمه هتاخده
+
+135
+00:10:59,320 --> 00:11:04,820
+في النظري مع الدكتور مازنهذا الـ enzyme إيش بيعمل؟
+
+136
+00:11:04,820 --> 00:11:09,960
+بيروح يربط الـ unconjugated bilirubin بمادة اسمها
+
+137
+00:11:09,960 --> 00:11:14,260
+الـ glucuronic acid ارتباط الـ unconjugated
+
+138
+00:11:14,260 --> 00:11:20,300
+bilirubin بمادة الـ glucuronic acid هيعطيني مركب
+
+139
+00:11:20,300 --> 00:11:25,360
+سموه conjugated bilirubin الـ bilirubin المرتبط
+
+140
+00:11:25,360 --> 00:11:30,300
+ليش حكيت عنه bilirubin مرتبط؟ لأن هو عبارة عنالـ
+
+141
+00:11:30,300 --> 00:11:33,960
+Unconjugated bilirubin الـ bilirubin غير مرتبط
+
+142
+00:11:33,960 --> 00:11:39,800
+ربطوه في مادة اسمها Glucuronic Acid فطلع عندي مركب
+
+143
+00:11:39,800 --> 00:11:46,900
+اسمه Bilirubin-Diglucuronate هذا هو الـ Conjugated
+
+144
+00:11:46,900 --> 00:11:50,420
+bilirubin هو الـ bilirubin المرتبط ربطوه في
+
+145
+00:11:50,420 --> 00:11:55,860
+Glucuronic Acid من ربطه الكبد بواسطة انزايم موجود
+
+146
+00:11:55,860 --> 00:12:01,210
+فيه تمام؟ففي الكابت اتحول الـ Unconjugated
+
+147
+00:12:01,210 --> 00:12:06,590
+bilirubin لـ Conjugated bilirubin تمام؟ هالجيت
+
+148
+00:12:06,590 --> 00:12:12,410
+الكابت هياخد جزء بسيط من هذا الـ Conjugated
+
+149
+00:12:12,410 --> 00:12:17,930
+bilirubin عبر أوردة و شرايين و يوديه على بلازمة
+
+150
+00:12:17,930 --> 00:12:23,310
+الدم إذا أصبح في بلازمة الدمفي عيننا الـ
+
+151
+00:12:23,310 --> 00:12:27,230
+Unconjugated bilirubin والـ Conjugated bilirubin
+
+152
+00:12:27,230 --> 00:12:31,650
+يعني أنه عين موجودين في بلازم الدم وبتراكيز قليلة
+
+153
+00:12:31,650 --> 00:12:38,080
+هذا الوضع الطبيعي تمام؟تمام طيب الـ conjugated
+
+154
+00:12:38,080 --> 00:12:43,140
+bilirubin حكينا جزء بسيط بواسطة الكبت و شرينه أو
+
+155
+00:12:43,140 --> 00:12:47,820
+ردته تم إيصاله لبلازمة الدم طيب الجزء الكبير اللي
+
+156
+00:12:47,820 --> 00:12:51,600
+ضايل ال conjugated bilirubin وين بدي يروح الجسم
+
+157
+00:12:51,600 --> 00:12:57,050
+بده يتخلص منه؟الـ Conjugated Billy-Robin بيروح
+
+158
+00:12:57,050 --> 00:13:04,130
+الكبد وهو عمله Execration بواسطة الـ Biliary Duct
+
+159
+00:13:04,130 --> 00:13:09,190
+شايفين؟ هي الكبد بعد الكبد مكتوب عندكوا الـ Bile
+
+160
+00:13:09,190 --> 00:13:14,150
+يعني الـ Biliary Duct يعني القناة السفرية هيمشي
+
+161
+00:13:14,150 --> 00:13:20,030
+الـ Conjugated Billy-Robinعبر القناة السفرية ويظل
+
+162
+00:13:20,030 --> 00:13:24,490
+ماشي لحد ما يصل لـ Small Intestine الأمعاء الدقيقة
+
+163
+00:13:24,490 --> 00:13:28,430
+تمام؟ هذه عندكم الأمعاء الدقيقة وهي الـ Conjugated
+
+164
+00:13:28,430 --> 00:13:35,520
+bilirubin واصل عندها تمام؟هلجيت في الأمعاء الضقيقة
+
+165
+00:13:35,520 --> 00:13:42,200
+فى عنا بكتيريا الـ Normaliflora هتحول المادة الـ
+
+166
+00:13:42,200 --> 00:13:47,460
+Conjugated bilirubin لمادة اسمها الـ Uropilinogen
+
+167
+00:13:47,460 --> 00:13:53,160
+تمام؟ يمكن سمعتوا فيها تمام بعدين مادة الـ
+
+168
+00:13:53,160 --> 00:13:57,900
+Uropilinogen اللى اتكونت في الأمعاء الضقيقة هتمشى
+
+169
+00:13:57,900 --> 00:14:04,140
+على الـ Large Intestine الأمعاء الغليظةوهناك برضه
+
+170
+00:14:04,140 --> 00:14:08,240
+هيصير فيه Oxidation أكسدة يعني في الأمعاء الغليظة
+
+171
+00:14:08,240 --> 00:14:13,120
+هيتم أكسدة الـUropilinogen وتحويله لمادة
+
+172
+00:14:13,120 --> 00:14:20,420
+الـUropilinبعد هيك المادة الـ European هتطلع مع
+
+173
+00:14:20,420 --> 00:14:26,600
+الستول خارج الجثم وبهيك الإنسان اتخلص من الـ
+
+174
+00:14:26,600 --> 00:14:30,900
+conjugated باليروبين عن طريق عمل له execution مع
+
+175
+00:14:30,900 --> 00:14:37,510
+الستول، تمام؟ هي طريقةالطريقة الأخرى أيضًا جزء من
+
+176
+00:14:37,510 --> 00:14:42,890
+الـUropilinogen قبل ما يتأكسد لـUropilin بيروح عبر
+
+177
+00:14:42,890 --> 00:14:50,230
+شرايين وأوردة بيصل الكدن تمام؟ بيصل الكلاوالكله
+
+178
+00:14:50,230 --> 00:14:56,130
+بتعمل Execration لمادة الـUropilinogen عن طريق مع
+
+179
+00:14:56,130 --> 00:14:59,530
+الـUrine يعني بتطلع الـUropilinogen مع الـUrine
+
+180
+00:14:59,530 --> 00:15:05,030
+وهذا بيثبت كلام لو جينا فحصنا الـUrine بالـStrip
+
+181
+00:15:05,030 --> 00:15:09,170
+تمام؟ مش فيه خانة لمادة الـUropilinogen يعني
+
+182
+00:15:09,170 --> 00:15:13,050
+تجاوزاً هي الـConjugated Bilirubin موجود في
+
+183
+00:15:13,050 --> 00:15:17,810
+الـUrine ولا مش موجود تمام؟ إذا نعيد لـChart كسرت
+
+184
+00:15:17,810 --> 00:15:23,440
+الـRBCsطلع الـ Hemoglobin منها الـ Hemoglobin
+
+185
+00:15:23,440 --> 00:15:28,440
+اتكسر طلع منه Unconjugated bilirubin ضال جزء منه
+
+186
+00:15:28,440 --> 00:15:32,800
+في البلازمة لكن كمية الأكبر لازم الجسم يتخلص منها
+
+187
+00:15:32,800 --> 00:15:38,580
+فبيروح على الكبد من خلال ناقل الألبومين بنجلوا على
+
+188
+00:15:38,580 --> 00:15:43,040
+الكبد لأنه غير ذائب في بلازمة الدم وفي الكبد هذا
+
+189
+00:15:43,040 --> 00:15:47,200
+الـ Unconjugated بتم ربطه بمادة الـ Glucuronic
+
+190
+00:15:47,200 --> 00:15:52,270
+Acidفبتكون عندى مُركّب الـ conjugated bilirubin
+
+191
+00:15:52,270 --> 00:15:56,470
+الـ bilirubin المرتبط تمام؟ هذا الـ bilirubin
+
+192
+00:15:56,470 --> 00:16:04,310
+المرتبط بتم أخذ جزء منه قليل جدا و بتم إيصاله إلى
+
+193
+00:16:04,310 --> 00:16:09,790
+البلازم الدم أما الكمية الأكبر الجسم بتخلص منها
+
+194
+00:16:09,790 --> 00:16:15,130
+إما عن طريق الـ stool أو عن طريق الـ urineمش إما
+
+195
+00:16:15,130 --> 00:16:18,390
+يعني بتخلص منه بالـ stool والـ urine يعني
+
+196
+00:16:18,390 --> 00:16:24,150
+الطريقتين كيف أن هذا الـ conjugated bilirubin بمشي
+
+197
+00:16:24,150 --> 00:16:27,850
+في الـ bilary duct في القناة الصفروية لحد ما يصل
+
+198
+00:16:27,850 --> 00:16:31,610
+الأمعاء الدقيقة وفي الأمعاء الدقيقة هناك بكتيريا
+
+199
+00:16:31,610 --> 00:16:37,230
+بتحوله لمادة europlenosinالـUropilinogen إما بيروح
+
+200
+00:16:37,230 --> 00:16:41,670
+على الـ يعني مش إما يعني هو جزء منه بيروح على
+
+201
+00:16:41,670 --> 00:16:46,930
+الكلمة و بيصيرله execution مع الـ urine و جزء منه
+
+202
+00:16:46,930 --> 00:16:54,150
+بتأكسد في الأمعاء الغليظة و بتحول لمادة Uropilin و
+
+203
+00:16:54,150 --> 00:16:59,410
+اللي بيصيرلها execution عن طريق الـ feces، تمام؟
+
+204
+00:16:59,410 --> 00:17:05,890
+هيك افهمنا الـ metabolism تبع الـ Billy Robinالـ
+
+205
+00:17:05,890 --> 00:17:09,890
+Conjugated bilirubin بشكل عام أو مباشر أو مباشر
+
+206
+00:17:09,890 --> 00:17:10,850
+بشكل عام أو مباشر أو مباشر بشكل عام أو مباشر بشكل
+
+207
+00:17:10,850 --> 00:17:12,290
+عام أو مباشر بشكل عام أو مباشر بشكل عام أو مباشر
+
+208
+00:17:12,290 --> 00:17:13,270
+بشكل عام أو مباشر بشكل عام أو مباشر بشكل عام أو
+
+209
+00:17:13,270 --> 00:17:13,910
+مباشر بشكل عام أو مباشر بشكل عام أو مباشر بشكل عام
+
+210
+00:17:13,910 --> 00:17:14,450
+أو مباشر بشكل عام أو مباشر بشكل عام أو مباشر بشكل
+
+211
+00:17:14,450 --> 00:17:14,630
+عام أو مباشر بشكل عام أو مباشر بشكل عام أو مباشر
+
+212
+00:17:14,630 --> 00:17:14,630
+بشكل عام أو مباشر بشكل عام أو مباشر بشكل عام أو
+
+213
+00:17:14,630 --> 00:17:17,000
+مباشر بشكل عامwith only minimal amounts entering
+
+214
+00:17:17,000 --> 00:17:19,900
+the bloodstream حكينا بهذا الموضوع أن الـ
+
+215
+00:17:19,900 --> 00:17:23,840
+bilirubin المرتبط اللي اتكون فيه الكبت بعد ما
+
+216
+00:17:23,840 --> 00:17:31,000
+يتكون جزء منه بيروح ع بلازم الدم وجزء قليل جدا أما
+
+217
+00:17:31,000 --> 00:17:35,680
+الكمية المتبقية الجسم بتخلص منها بتخلص منها
+
+218
+00:17:35,680 --> 00:17:39,740
+الطريقتين بال gastrointestinal tract يعني بواسطة
+
+219
+00:17:39,810 --> 00:17:44,890
+الجهاز الغضبي لأنه حكينا الـ Conjugated بيمشي
+
+220
+00:17:44,890 --> 00:17:49,410
+بالقناة السفرية بيروح لأمعاء دقيقة بعدين الأمعاء
+
+221
+00:17:49,410 --> 00:17:55,070
+الغليظة وبعدين Execration مع الفيسس بطلع مع الفيسس
+
+222
+00:17:55,070 --> 00:18:00,870
+تمام؟ أيضا الجسم بتخلص منه عن طريق ال kidney بيروح
+
+223
+00:18:00,870 --> 00:18:05,760
+على ال kidney وال kidney بتطلعه مع ال urineit is
+
+224
+00:18:05,760 --> 00:18:09,760
+level rises in the blood when obstructive jaundice
+
+225
+00:18:09,760 --> 00:18:14,660
+as from gall stones or hepatic jaundice occurs
+
+226
+00:18:14,660 --> 00:18:20,260
+كلمة or hepatic jaundice occur احذفوها إذا الجملة
+
+227
+00:18:20,260 --> 00:18:24,340
+it is level rises in the blood when obstructive
+
+228
+00:18:24,340 --> 00:18:27,950
+jaundice as from gall stonesفي هذه الجملة بيحكينا
+
+229
+00:18:27,950 --> 00:18:32,510
+إن الـ Conjugated bilirubin بزداد تركيزه في الدم
+
+230
+00:18:32,510 --> 00:18:36,710
+متى حالة مرضية، في حالة الـ Obstructive jaundice
+
+231
+00:18:36,710 --> 00:18:40,430
+إيش يعني Obstructive jaundice؟ يعني كلمة
+
+232
+00:18:40,430 --> 00:18:44,690
+Obstructive انسداد بالحصاوي، بالـ Gallstoneتخيلوا
+
+233
+00:18:44,690 --> 00:18:50,270
+معي إنه القناة الصفراوية اتكون فيها stones اتكون
+
+234
+00:18:50,270 --> 00:18:54,350
+فيها حصاوي هلجيت ال conjugated Billy Robin اتكون
+
+235
+00:18:54,350 --> 00:18:58,290
+في الكبد و بده يمشي في القناة الصفراوية عشان يروح
+
+236
+00:18:58,290 --> 00:19:02,870
+للأمعاء، تمام؟في القناة السفرية في حصاوي يعني مش
+
+237
+00:19:02,870 --> 00:19:08,230
+هيقدر يمشي ال conjugated باليروبين تمام؟ وبالتالي
+
+238
+00:19:08,230 --> 00:19:11,850
+إيش هيصير؟ إيش هيعمل؟ مش هيقدر ينزل لتحت وينزل
+
+239
+00:19:11,850 --> 00:19:15,950
+للأمعاء وبالتالي يطلع مع ال thesis فهيضلوا محجوب
+
+240
+00:19:15,950 --> 00:19:21,290
+فوق على بلازم الدم هيرجع على بلازم الدم يرجع بشكل
+
+241
+00:19:21,290 --> 00:19:26,900
+عكسي لفوق لبلازم الدم إذا موجودحثاوي في القناة
+
+242
+00:19:26,900 --> 00:19:32,540
+الصفرية هتمنع دخول الـ conjugated bilirubin عبر
+
+243
+00:19:32,540 --> 00:19:36,420
+هذه القناة هو بيمشي عبر هذه القناة عشان يصل
+
+244
+00:19:36,420 --> 00:19:40,100
+الأمعاء وبالتالي مش هيقدر يصل الأمعاء ومش هيطلع
+
+245
+00:19:40,100 --> 00:19:44,780
+برا الجسم وبالتالي هيطلع لفوق ويرجع لـ Plasma الدم
+
+246
+00:19:44,780 --> 00:19:51,230
+ويزيد تركيزههلجيت لما الـ conjugated bilirubin
+
+247
+00:19:51,230 --> 00:19:56,350
+يزيد هذه حالة مرضية يفترض يكون هو تركيزه في ال
+
+248
+00:19:56,350 --> 00:20:01,010
+plasma ده قليل جدا لكن لما بيزيد معناه أن هذه حالة
+
+249
+00:20:01,010 --> 00:20:06,360
+مرضيةIn this case, the bilirubin is unable to
+
+250
+00:20:06,360 --> 00:20:09,880
+reach the intestines في هذه الحالة، الـ bilirubin
+
+251
+00:20:09,880 --> 00:20:14,620
+مش قادر يصل الأمعاء عشان يطلع مع الـ feces for
+
+252
+00:20:14,620 --> 00:20:19,560
+excretion مش قادر and instead enter the
+
+253
+00:20:19,560 --> 00:20:23,800
+bloodstream for excretion by the kidneysعشان هيك
+
+254
+00:20:23,800 --> 00:20:27,320
+إيش بيسوي؟ بيروح بيروح على بلازمة الدم برجع
+
+255
+00:20:27,320 --> 00:20:32,700
+لبلازمة الدم وبتراكم في بلازمة الدم وما بيلاقي حل
+
+256
+00:20:32,700 --> 00:20:39,260
+إلا إنه يروح على ال kidney وال kidney اتطلعه مع ال
+
+257
+00:20:39,260 --> 00:20:44,980
+urine عشان هيك لو فحصنا ال conjugated bilirubin في
+
+258
+00:20:44,980 --> 00:20:49,240
+ال urine حنلاقيه عالي كتير كتير أعلى من الإنسان
+
+259
+00:20:49,240 --> 00:20:53,800
+الطبيعي، ليش؟لأنه أصلاً هو عالي في بلازمة الدم
+
+260
+00:20:53,800 --> 00:20:58,060
+وبالتالي هيروح على الـ kidney و الـ kidney إيش
+
+261
+00:20:58,060 --> 00:21:04,100
+هتعمل؟ هتعمله execution مع الـ urine و هيزيد
+
+262
+00:21:04,100 --> 00:21:09,830
+تركيزه أكتر في الـ urineوفي بلازمة دم Conjugated
+
+263
+00:21:09,830 --> 00:21:13,790
+bilirubin is the only type of bilirubin able to
+
+264
+00:21:13,790 --> 00:21:17,650
+cross the glomerulus filter. This it is the only
+
+265
+00:21:17,650 --> 00:21:20,770
+type of bilirubin that can be found in the urine
+
+266
+00:21:21,840 --> 00:21:25,220
+أصلا الـ Unconjugated bilirubin الـ bilirubin
+
+267
+00:21:25,220 --> 00:21:30,360
+الغير مرتبط بيطلع من الـ RBCs عطول بيطلع من تكسير
+
+268
+00:21:30,360 --> 00:21:33,500
+الـ RBCs يعني من تكسير الـ Hemoglobin و بيضل جزء
+
+269
+00:21:33,500 --> 00:21:37,240
+منه في بلازم الدم و كله بيروح على الكبد و بيتحول
+
+270
+00:21:37,240 --> 00:21:41,400
+لـ Conjugated يعني الـ Unconjugated bilirubin لا
+
+271
+00:21:41,400 --> 00:21:45,860
+بيشوف الكلة ولا بيشوف الأمعاء ولا بيطلع مع الـ
+
+272
+00:21:45,860 --> 00:21:50,570
+urine ولا بيطلع مع الـ feces تمام؟لكن النوع
+
+273
+00:21:50,570 --> 00:21:55,110
+المرتبط الـ bilirubin الـ conjugated المرتبط بيمر
+
+274
+00:21:55,110 --> 00:21:59,010
+على الأمعاق و بطلع مع الـ feces أيضًا بيمر على
+
+275
+00:21:59,010 --> 00:22:03,450
+الكدن مش حاكينا الـ uropilinogen جزء منه بيروح على
+
+276
+00:22:03,450 --> 00:22:08,070
+الكدن و بيصير له execution مع ال urine يعني ال
+
+277
+00:22:08,070 --> 00:22:12,260
+conjugated bilirubin هو النوع الوحيد اللي بيمرعلى
+
+278
+00:22:12,260 --> 00:22:18,380
+الـ kidney وبتم عمل له عملية فلترة وخروج مع الـ
+
+279
+00:22:18,380 --> 00:22:22,620
+urine لكن الـ unconjugated ما بيشوف لا kidney ولا
+
+280
+00:22:22,620 --> 00:22:29,060
+intestine كله بتحول لـ conjugatedأما النوع الآخر
+
+281
+00:22:29,060 --> 00:22:32,940
+الـ Unconjugated bilirubin الـ bilirubin الغير
+
+282
+00:22:32,940 --> 00:22:36,620
+مرتبط أو بيسموه الـ indirect bilirubin أو الـ
+
+283
+00:22:36,620 --> 00:22:39,720
+unconjugated bilirubin is normally found in the
+
+284
+00:22:39,720 --> 00:22:45,480
+bloodstream فقط أنا بشوفه في الدم بتركيز قليل جدا
+
+285
+00:22:45,480 --> 00:22:50,720
+الوضع الطبيعي Unconjugated bilirubin rises in case
+
+286
+00:22:50,720 --> 00:22:55,030
+of hemolytic jaundiceمتى بيزيد الـ Unconjugated
+
+287
+00:22:55,030 --> 00:22:59,540
+bilirubin في حالات الـ Hemolytic Anemia؟ركزوا معي
+
+288
+00:22:59,540 --> 00:23:03,640
+لما بيصير عندي homolytic anemia يعني الـ RBCs اللي
+
+289
+00:23:03,640 --> 00:23:08,340
+بتتكون و بتصل الدم بسرعة بتتكسر معناه في عندي RBC
+
+290
+00:23:08,340 --> 00:23:12,900
+بتتكسر بشكل أكبر معناه Hemoglobins هيصير له
+
+291
+00:23:12,900 --> 00:23:18,020
+release و يتكسر بشكل أكبر معناه حاصل تكسير ال
+
+292
+00:23:18,020 --> 00:23:22,500
+Hemoglobin هيطلع Unconjugated bilirubin بكميات
+
+293
+00:23:22,500 --> 00:23:27,390
+كبيرة في bloodstream في الدمالـ breakdown of
+
+294
+00:23:27,390 --> 00:23:32,110
+hemoglobin results in a higher than normal level
+
+295
+00:23:32,110 --> 00:23:36,390
+of unconjugated bilirubin being present in the
+
+296
+00:23:36,390 --> 00:23:40,110
+bloodstream اللي صار انه حالات الـ hemolytic
+
+297
+00:23:40,110 --> 00:23:46,530
+anemia حلق صعبة عند كميات كبيرة من ال RBCs بتتصنع
+
+298
+00:23:46,530 --> 00:23:51,720
+وبالتالي كلها اتتكسرأي RBCs تتصنع بسرعة بتتكسر
+
+299
+00:23:51,720 --> 00:23:56,040
+فعندي حجم هائل من الـ RBCs بتتكسر وبتطلع
+
+300
+00:23:56,040 --> 00:23:59,880
+Hemoglobin برضه الـ Hemoglobin بيتكسر وبيعطينا الـ
+
+301
+00:23:59,880 --> 00:24:04,340
+Unconjugated bilirubin بكميات أكبر من الوضع الـ
+
+302
+00:24:04,340 --> 00:24:08,100
+Normal، تمام؟ إذن الـ Unconjugated bilirubin بيزيد
+
+303
+00:24:08,100 --> 00:24:12,080
+في حالات الـ Hemolytic Anemia لكن الـ Conjugated
+
+304
+00:24:12,080 --> 00:24:16,380
+bilirubin الـ bilirubin المرتبط حكينا بيزيد في حال
+
+305
+00:24:16,750 --> 00:24:22,690
+اتكونت حصاوي في العصارة أو في القناة الصفراوية
+
+306
+00:24:22,690 --> 00:24:28,280
+تمام؟This is the type of bilirubin elevated in
+
+307
+00:24:28,280 --> 00:24:32,240
+cases of hepatocellular dysfunction such as
+
+308
+00:24:32,240 --> 00:24:36,540
+hepatitis الـ Unconjugated bilirubin بزيد في حالات
+
+309
+00:24:36,540 --> 00:24:41,600
+الـ hemolytic أنيميا وأيضا بزيد في حالة صار في
+
+310
+00:24:41,600 --> 00:24:45,640
+عنده hepatocellular dysfunction مشكلة في خلايا
+
+311
+00:24:45,640 --> 00:24:49,870
+الكبدإيش هذه المشكلة؟ مثلًا Hepatitis Hepatitis
+
+312
+00:24:49,870 --> 00:24:54,070
+معناه التهاب في خلايا الكبد بغض نظر عن سبب الاتهاب
+
+313
+00:24:54,070 --> 00:24:59,450
+فيروس كحول أيا كان خلايا الكبد حدث فيها مشكلة حدث
+
+314
+00:24:59,450 --> 00:25:05,730
+فيها damage تمام؟حلجات الـ RBCs اتكسّرت وطلعت الـ
+
+315
+00:25:05,730 --> 00:25:09,990
+Hemoglobin الـ Hemoglobin اتكسّر و أعطاني
+
+316
+00:25:09,990 --> 00:25:15,570
+Unconjugated Bilirubin أجى الألبم حمله وودّاه على
+
+317
+00:25:15,570 --> 00:25:21,720
+الكبد الكبد فيه مشكلةفي التهاب في خلاياه تمام؟
+
+318
+00:25:21,720 --> 00:25:27,000
+وبالتالي مش هيقدر الكبد يحول الـ Unconjugated
+
+319
+00:25:27,000 --> 00:25:31,340
+bilirubin لconjugated bilirubin وبالتالي إيش اللي
+
+320
+00:25:31,340 --> 00:25:34,700
+هيصير؟ إيش متوقعين يصير؟ متوقعين إن الـ
+
+321
+00:25:34,700 --> 00:25:39,860
+Unconjugated bilirubin هيزيد تركيزه في بلازمة الدم
+
+322
+00:25:39,860 --> 00:25:44,910
+لإن الكبد في خلل، في مشكلةمش جادر يحوله مش جادر
+
+323
+00:25:44,910 --> 00:25:50,110
+يربطه بمادة الـglucuronic acid ويحوله ل conjugated
+
+324
+00:25:50,110 --> 00:25:55,030
+bilirubin إذا الـunconjugated bilirubin بيزداد في
+
+325
+00:25:55,030 --> 00:25:59,190
+حالة الـhemolytic أنيميا وحالات الـHepatitis،
+
+326
+00:25:59,190 --> 00:26:04,540
+تمام؟هنا عملنا جدول فرجلنا بين الـ bilirubin
+
+327
+00:26:04,540 --> 00:26:09,120
+المرتبط بمادة الـglucuronic acid والـ bilirubin
+
+328
+00:26:09,120 --> 00:26:13,560
+الغير مرتبط اللي بيطلع بسرعة من الـ hemoglobin
+
+329
+00:26:13,560 --> 00:26:18,020
+المتكسر تمام؟ ال conjugated bilirubin، الـ
+
+330
+00:26:18,020 --> 00:26:21,930
+bilirubin المرتبط بيسموه الـ directبلي روبن البلي
+
+331
+00:26:21,930 --> 00:26:26,130
+روبن المباشر الصفة التانية له انه water soluble
+
+332
+00:26:26,130 --> 00:26:30,750
+دائب في الميه يعني دائب في بلازمة دم يعني بيمشي في
+
+333
+00:26:30,750 --> 00:26:35,730
+بلازمة دم من غير اي carrier من غير اي ناقل تمام
+
+334
+00:26:35,730 --> 00:26:41,770
+found in urine بشوفه في ال urine لأن جزء منه بيروح
+
+335
+00:26:41,770 --> 00:26:45,770
+على الكلاق وبالتالي بيصير له execution عن طريق ال
+
+336
+00:26:45,770 --> 00:26:53,500
+urineبصيرله execution عن طريق الكدنى وبالتالي
+
+337
+00:26:53,500 --> 00:27:02,060
+بيطلع مع الـ urine مابتدوش أي محفز أثناء التفاعل،
+
+338
+00:27:02,060 --> 00:27:05,880
+هذه هنشوفها أكتر إشي في التفاعل يعني مابدوه في الـ
+
+339
+00:27:05,880 --> 00:27:10,000
+kit الخاص في ورّي أيجينت تبع الـ conjugated Billy
+
+340
+00:27:10,000 --> 00:27:16,000
+Robin مابيكون فيه أي محفز لشغلهأما الـ Bilirubin
+
+341
+00:27:16,000 --> 00:27:20,960
+الغير مرتبط أو بيسموه غير مباشر هو water insoluble
+
+342
+00:27:20,960 --> 00:27:25,000
+غير دائب في الميه يعني غير دائب في بلازمة الدم لما
+
+343
+00:27:25,000 --> 00:27:29,120
+طلع من ال RBCs يعني طلع من ال hemoglobin اللي
+
+344
+00:27:29,120 --> 00:27:34,180
+موجود جواهات ال RBCs طلع وصل بلازمة الدم لما راح
+
+345
+00:27:34,180 --> 00:27:38,760
+على الكبت حكينا إجا ال album اللي نقله ال album
+
+346
+00:27:38,760 --> 00:27:43,340
+عبارة عن ال protein بشتغل ك transporter ناقلبنقل
+
+347
+00:27:43,340 --> 00:27:49,420
+الـ Unconjugated bilirubin من الدم إلى الكبد Not
+
+348
+00:27:49,420 --> 00:27:53,100
+found in urine تفاجنا لا بشوفه في urine ولا بشوفه
+
+349
+00:27:53,100 --> 00:27:57,560
+في feces تمام؟ needs accelerator يعني أثناء
+
+350
+00:27:57,560 --> 00:28:03,160
+التفاعل وفي ال reaction نحتاج إلى محفزالـ Total
+
+351
+00:28:03,160 --> 00:28:06,620
+Bilirubin الـ kit أنا لما بحكيلكوا بدنا نفحص Total
+
+352
+00:28:06,620 --> 00:28:12,780
+Bilirubin معناه الـ kit هذا بيحسبلي ال conjugated
+
+353
+00:28:12,780 --> 00:28:16,660
+bilirubin زائد ال unconjugated bilirubin يعني
+
+354
+00:28:16,660 --> 00:28:20,760
+بيحسبلي كل ال bilirubin اللي موجود في بلازم الدم
+
+355
+00:28:20,760 --> 00:28:25,380
+سواء المرتبط أو الغير مرتبط يعني conjugated زائد
+
+356
+00:28:25,380 --> 00:28:29,200
+unconjugated bilirubin typically only the total
+
+357
+00:28:29,200 --> 00:28:33,640
+bilirubin is reported عادة يا جماعةالدكتور بطلب
+
+358
+00:28:33,640 --> 00:28:38,800
+الـ Total Billy-Robin وبنسجل نتيجته لكن لو لاحظ
+
+359
+00:28:38,800 --> 00:28:42,300
+الدكتور إنه فيه مشكلة في الـ Total Billy-Robin
+
+360
+00:28:42,300 --> 00:28:46,780
+مثلًا الـ Total Billy-Robin عالي، تمام؟ ساعتها
+
+361
+00:28:46,780 --> 00:28:50,990
+بطلبالـ Direct والـ Indirect باللي روبن ساعتها
+
+362
+00:28:50,990 --> 00:28:55,410
+بيطلب فحص الأنواع الإتنين عشان يعرف وين المشكلة
+
+363
+00:28:55,410 --> 00:28:59,170
+بالظبط المشكلة في ال Direct باللي روبن ولا ال
+
+364
+00:28:59,170 --> 00:29:02,730
+Indirect باللي روبن مين اللي فيه مشكلة ومين اللي
+
+365
+00:29:02,730 --> 00:29:07,110
+زايد تمام؟إذا كان الفحص الـ Total بيه مشكلة إذا
+
+366
+00:29:07,110 --> 00:29:12,350
+كان الفحص الـ Total بيه مشكلة تجارب تجارب تجارب
+
+367
+00:29:12,350 --> 00:29:13,970
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+368
+00:29:13,970 --> 00:29:15,330
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+369
+00:29:15,330 --> 00:29:16,930
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+370
+00:29:16,930 --> 00:29:17,210
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+371
+00:29:17,210 --> 00:29:17,370
+تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب
+
+372
+00:29:17,370 --> 00:29:22,290
+تجارب تجارب تجارب تجارب تجارب تجفحص الـ Direct
+
+373
+00:29:22,290 --> 00:29:27,090
+والـ Indirect الفحصين اعملهم على حدة نشوف وين
+
+374
+00:29:27,090 --> 00:29:30,150
+المشكلة بالظبط يعني بدنا نفهم ان ال Direct بلي
+
+375
+00:29:30,150 --> 00:29:36,530
+روبن له kit وال Indirect بلي روبن أيضا له kitممكن
+
+376
+00:29:36,530 --> 00:29:40,270
+أنا أقيس الـ Total Billy-Robin بالـ kit الخاص فيه
+
+377
+00:29:40,270 --> 00:29:45,710
+و أطرحه و أعمل فحص ال conjugated بس و أطرحه من ال
+
+378
+00:29:45,710 --> 00:29:49,210
+conjugated بتطلعلي تركيز ال unconjugated Billy
+
+379
+00:29:49,210 --> 00:29:52,570
+-Robin أو العكس Total Billy-Robin ناقص ال
+
+380
+00:29:52,570 --> 00:29:56,990
+unconjugated بتطلعلي ال conjugated يعني ممكن أعمل
+
+381
+00:29:56,990 --> 00:30:00,690
+ال total Billy-Robin و أعمل واحد من الاتنين و
+
+382
+00:30:00,690 --> 00:30:06,200
+بطرحه من بعض بتطلعلي التالت واضح؟لـ Clinical
+
+383
+00:30:06,200 --> 00:30:11,220
+Significance أهمية الفحص حالات بيزيد فيها الـ
+
+384
+00:30:11,220 --> 00:30:14,720
+Conjugated bilirubin الحالة الأولى حكيناها الـ
+
+385
+00:30:14,720 --> 00:30:18,700
+Biliary Obstruction انسداد في الـ Biliary Duct في
+
+386
+00:30:18,700 --> 00:30:23,080
+القناع الصفراوية هلجيت الـ Conjugated bilirubin
+
+387
+00:30:23,080 --> 00:30:28,130
+اتكول فيه الكبتوبدّه يصيرله Execration حكينا بيمر
+
+388
+00:30:28,130 --> 00:30:32,090
+عبر القناة الصفرية بعدين بروح على الأمعاق عشان
+
+389
+00:30:32,090 --> 00:30:36,450
+يطلع مع الـ stool لكن لو لاجى Stones حصاوي في هذه
+
+390
+00:30:36,450 --> 00:30:40,870
+القناة مش هيقدر يمشي فيها وبالتالي هيرجع بشكل
+
+391
+00:30:40,870 --> 00:30:46,010
+reverse على الكبد مرة أخرى وبعدين هيطلع على إبلازم
+
+392
+00:30:46,010 --> 00:30:51,590
+الدم ويزيد تركيزه في الدم، تمام؟الحالة التانية
+
+393
+00:30:51,590 --> 00:30:56,010
+Cancer of the head of the pancreas حدوث سرطان في
+
+394
+00:30:56,010 --> 00:31:01,970
+أعلى البنكرياس لو جينا تخيلنا التركيبة الكبد تحت
+
+395
+00:31:01,970 --> 00:31:06,550
+المرارة زي ما تذكرين جنب الكبد بسرعة البنكرياس أو
+
+396
+00:31:06,550 --> 00:31:12,360
+لتحته شويةهل جاد الـ liver والأمعاء إيش اللي بيوصل
+
+397
+00:31:12,360 --> 00:31:16,440
+بينهم؟ الـ bilary duct القناة الصفراوية كذلك
+
+398
+00:31:16,440 --> 00:31:22,200
+البنكرياس والأمعاء إيش بيوصل بينهم؟ برضه الـ
+
+399
+00:31:22,200 --> 00:31:25,800
+bilary duct برضه القناة الصفراوية لأنه يا جماعة
+
+400
+00:31:25,800 --> 00:31:31,190
+البنكرياس مش بس بيفرز هرمونات زي الإنسلينبرضه الـ
+
+401
+00:31:31,190 --> 00:31:37,410
+Pancreas بيفرذ أميلاز و ليباز هذه أنزيمات بيفرذها
+
+402
+00:31:37,410 --> 00:31:41,990
+الـ Pancreas و بتمشي عبر القناة الصفراوية و بتروح
+
+403
+00:31:41,990 --> 00:31:46,230
+على الأمعاء عشان تساعد في هضم الطعام تساعد في هضم
+
+404
+00:31:46,230 --> 00:31:50,750
+الـ ليباز بيساعد في هضم الدهون الـ Amylase بيساعد
+
+405
+00:31:50,750 --> 00:31:56,860
+في هضم الـ Carbohydrate تمام؟ وبالتاليلما بيصير
+
+406
+00:31:56,860 --> 00:32:01,920
+عند الـ Cancer بالـ Pancreas معنى الكلام ممكن الـ
+
+407
+00:32:01,920 --> 00:32:06,300
+Cancer يمد على الـ Biliary Duct يعني ممكن يصيرله
+
+408
+00:32:06,300 --> 00:32:11,990
+Metastasis ينتشر ويمد ويصيب القناة الصفراويةفلما
+
+409
+00:32:11,990 --> 00:32:17,190
+بيصير عندي cancer في القناة الصفراوية برضه هتتأثر
+
+410
+00:32:17,190 --> 00:32:21,610
+القناة وبالتالي الـ conjugated دليروبين اللي اتكون
+
+411
+00:32:21,610 --> 00:32:28,210
+فيه الكبد مش هيقدر يمشي عبر هذه القناة لأن خلايا
+
+412
+00:32:28,210 --> 00:32:34,280
+هذه القناة ضربتومش هيقدر يمشي من خلال القناة
+
+413
+00:32:34,280 --> 00:32:38,600
+السفرية ويروح على الأمعاء وبالتالي هيضل فيه الكبد
+
+414
+00:32:38,600 --> 00:32:43,640
+ويرجع على بلازمة الدم ويزيد تركيزه إذا سرطان في
+
+415
+00:32:43,640 --> 00:32:48,020
+الـ pancreas ممكن يمد هذا السرطان على القناة
+
+416
+00:32:48,020 --> 00:32:51,880
+السفرية اللي هيمشي فيها الـ conjugated bilirubin
+
+417
+00:32:51,880 --> 00:32:56,140
+فلو صار في القناةCancer معناه مش هيقدر الـ
+
+418
+00:32:56,140 --> 00:32:59,000
+conjugated bilirubin يعبر ويروح على الأمعاق
+
+419
+00:32:59,000 --> 00:33:03,020
+وبالتالي هيزداد تركيزه في الدم حالات الدوبين
+
+420
+00:33:03,020 --> 00:33:07,680
+جونسون سيندروم هذه syndrome يعني أكيد مرض وراثي
+
+421
+00:33:07,680 --> 00:33:12,060
+هذا المرض الوراثي معناه أنه أنا بيصير في عندى
+
+422
+00:33:12,060 --> 00:33:18,170
+مشكلة في الـBiliary duct تمام؟مشكلة وراثية في
+
+423
+00:33:18,170 --> 00:33:21,950
+القناة الصفراوية بيصير فيها obstruction بيصير فيها
+
+424
+00:33:21,950 --> 00:33:26,670
+incident سبب الincident مش حصاوي إنما هو وراثي
+
+425
+00:33:26,670 --> 00:33:30,050
+يعني مثلا ممكن الشخص ينولد عنده القناة الصفراوية
+
+426
+00:33:30,050 --> 00:33:34,190
+مغلقة مش فاتحة تمام؟ وبالتالي بيجي ال conjugated
+
+427
+00:33:34,190 --> 00:33:37,850
+بلي روبين اتكون فيه الكبد بده يطلع عبر هذا القناة
+
+428
+00:33:37,850 --> 00:33:42,620
+بيلاجيهامغلقة هذه الـ Syndrome بنسميها Dopine
+
+429
+00:33:42,620 --> 00:33:49,040
+Johnson Syndrome حدوث غلق في القدم بشكل وراسي
+
+430
+00:33:49,040 --> 00:33:54,590
+تمام؟أما الـ Unconjugated Billy Robin ماتة بالزيد
+
+431
+00:33:54,590 --> 00:33:58,770
+يا جماعة أول حالة حكنها Autoimmune Hemolysis يعني
+
+432
+00:33:58,770 --> 00:34:03,990
+Hemolytic Anemia لما بيصير عنده ال RBCs بتعرف
+
+433
+00:34:03,990 --> 00:34:08,030
+عليها الجسم كأنها خلايا غريبة وبالتالي بيطلعلها
+
+434
+00:34:08,030 --> 00:34:12,490
+Antibody بهجمها بتتكسر وبالتالي بيطلعله مجلبا و
+
+435
+00:34:12,490 --> 00:34:16,670
+بتكسرونتيجة تكسير الـ Hemoglobin بتطلع الـ
+
+436
+00:34:16,670 --> 00:34:20,070
+Unconjugated bilirubin طبعا Hemolytic Anemia يعني
+
+437
+00:34:20,070 --> 00:34:25,290
+تكسير مهول في الـ RBCs يعني هيطلع Unconjugated
+
+438
+00:34:25,290 --> 00:34:33,240
+bilirubin بكميات كبيرة، تمام؟حالات الكريجلر نجار
+
+439
+00:34:33,240 --> 00:34:39,520
+سيندروم كريجلر نجار سيندروم هذه مرض وراسي بيصير في
+
+440
+00:34:39,520 --> 00:34:45,420
+عندي طفرة في الجين المسئول عن تصنيع الـ enzyme
+
+441
+00:34:45,420 --> 00:34:49,820
+اللي مسئول عن الـ conjugation مش حاكينا في الكبد
+
+442
+00:34:50,730 --> 00:34:54,930
+بيجي الـ Unconjugated bilirubin عشان يتحول عشان
+
+443
+00:34:54,930 --> 00:35:00,110
+يتم ربطه بالـ Glucuronic Acid هلجيت حكينا مين بربط
+
+444
+00:35:00,110 --> 00:35:03,210
+الـ Unconjugated bilirubin بالـ Glucuronic Acid؟
+
+445
+00:35:03,210 --> 00:35:07,930
+حكينا فيه Enzyme موجود في الكبد لكن لو هذا الإنسان
+
+446
+00:35:07,930 --> 00:35:11,850
+عنده Crigler Najjar Syndrome يعني مش هيتم تصنيع
+
+447
+00:35:11,850 --> 00:35:17,490
+هذا الـ Enzyme في الكبد بسبب مشكلة ورثيةبالتالي مش
+
+448
+00:35:17,490 --> 00:35:22,290
+هيصير ارتباط للـ Unconjugated bilirubin مش هيتم
+
+449
+00:35:22,290 --> 00:35:25,870
+ربطه بالـ Glucuronic Acid وبالتالي إيش المحصلة؟ إن
+
+450
+00:35:25,870 --> 00:35:30,110
+الـ Unconjugated bilirubin هيظل عالي في بلازمة دم
+
+451
+00:35:30,110 --> 00:35:32,830
+على الفاضي هييجي على الكبد على الفاضي الكبد مش
+
+452
+00:35:32,830 --> 00:35:38,290
+هيقدر يعمل ربط لأنه مافيش إنزايم جواته يعمل هذا
+
+453
+00:35:38,290 --> 00:35:43,680
+الربط حالات الـ Gilbert Syndromeالـ Gilbert
+
+454
+00:35:43,680 --> 00:35:47,760
+Syndrome اللي جات الـ Unconjugated بيلي روبن طلع
+
+455
+00:35:47,760 --> 00:35:52,720
+من الـ RBCs مين الـ carrier له، مين اللي حمله على
+
+456
+00:35:52,720 --> 00:35:56,780
+الكبت حكينا الألبما، هذا ناقل للـ Unconjugated
+
+457
+00:35:56,780 --> 00:36:02,010
+بيلي روبن لأنه ما بيقدر يمشي في بلازمة دهانحملهم
+
+458
+00:36:02,010 --> 00:36:06,090
+وبالتالي وراحوا علي الكبد هلجيت قبل ما يفوتوا
+
+459
+00:36:06,090 --> 00:36:10,310
+الكبد يا جماعة؟ فيه Receptor على سطح الكبد تمام؟
+
+460
+00:36:10,310 --> 00:36:14,650
+هذا الـReceptor الـUnconjugated Billy-Robin برتبط
+
+461
+00:36:14,650 --> 00:36:18,370
+عليها وبعدين الكبد بيسحب الـUnconjugated Billy
+
+462
+00:36:18,370 --> 00:36:21,690
+-Robin للداخل لكن الناس اللي عندهم Gilbert
+
+463
+00:36:21,690 --> 00:36:27,460
+Syndromeبكون عندهم بشكل وراسي مشكلة في الـ
+
+464
+00:36:27,460 --> 00:36:31,540
+Receptor اللي موجودة على سطح الكبت اللي بدي يرتبط
+
+465
+00:36:31,540 --> 00:36:35,580
+فيها الـ Unconjugated bilirubin عشان يدخل لجوا
+
+466
+00:36:35,580 --> 00:36:39,600
+الكبت عشان هيك في حالات الـ Gilbert Syndrome أصلا
+
+467
+00:36:39,600 --> 00:36:42,720
+الـ Unconjugated bilirubin مقدرش يفوت جوا الكبت
+
+468
+00:36:42,720 --> 00:36:47,000
+فهيضلوا فيه بلازمة دم عالي حالات الـ Hemolytic
+
+469
+00:36:47,000 --> 00:36:50,840
+Transfusion Reaction يعني عمليات نجلة الدم، في ناس
+
+470
+00:36:50,840 --> 00:36:54,430
+كتير بنقولولهم الدمبعد فترة بيصير عندهم Hemolysis
+
+471
+00:36:54,430 --> 00:37:00,670
+أو نجلناله دم فصيلة غير فصيلته، تمام؟ المحصلة
+
+472
+00:37:00,670 --> 00:37:04,790
+هيصير في تكسير للـRBCs بكميات أكبر، يعني تكسير
+
+473
+00:37:04,790 --> 00:37:08,710
+للـHemoglobin، يعني خروج الـUnconjugated bilirubin
+
+474
+00:37:08,710 --> 00:37:14,490
+بشكل مهول من الـRBCs حالات الـHepatitis، اتفجنالما
+
+475
+00:37:14,490 --> 00:37:18,570
+خلايا الكبد يكون فيها مشكلة، يكون فيها التهاب بيجي
+
+476
+00:37:18,570 --> 00:37:22,330
+الـ Unconjugated bilirubin بده يتحول لـ Conjugated
+
+477
+00:37:22,330 --> 00:37:26,150
+bilirubin، خلايا الكبد ماتقدر يتحولوا لأنه فيها
+
+478
+00:37:26,150 --> 00:37:31,310
+مشكلة المحصلة إن الـ Unconjugated bilirubin تركيزه
+
+479
+00:37:31,310 --> 00:37:36,810
+بارتفاع في الدم، تمام؟طبعًا يا جماعة التفسير إن
+
+480
+00:37:36,810 --> 00:37:41,970
+هذه الـ Syndrome إيش هي هذا الكلام لأ مش هتضبكوا
+
+481
+00:37:41,970 --> 00:37:47,870
+فيه فقط للمعرفة بس إن الحالات المهمة هذه يعني بدنا
+
+482
+00:37:47,870 --> 00:37:50,630
+نعرف إيش الحالات اللي بيزيد فيها الـ Conjugated و
+
+483
+00:37:50,630 --> 00:37:53,690
+الحالات اللي بيزيد فيها الـ Unconjugated ومش ضروري
+
+484
+00:37:53,690 --> 00:37:57,150
+التفسير اللي أنا شرحته فقط للعلم، تمام؟
+
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/AJ9OpH9yA0U_postprocess.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/AJ9OpH9yA0U_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..6fc8faa6243976bf246eed541607529f77306036
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/AJ9OpH9yA0U_postprocess.srt
@@ -0,0 +1,1460 @@
+1
+00:00:01,100 --> 00:00:05,940
+هنستكمل محاضرتنا طبعا بس بدي أحكي شغلة هلجيت لما
+
+2
+00:00:05,940 --> 00:00:10,700
+أنا مثّلت نتائج الـcontrol اللي حصلت عليها خلال
+
+3
+00:00:10,700 --> 00:00:16,100
+عشرين يوم على الـchart الـLevy Genes Chart هذه
+
+4
+00:00:16,100 --> 00:00:21,440
+النتائج كيف بتعرف إن هذه النتيجة مقبولة أو مرفوضة؟
+
+5
+00:00:21,440 --> 00:00:27,990
+بيحكيلي نتائج الـcontrol المقبولة لازم تكونموجودة
+
+6
+00:00:27,990 --> 00:00:34,510
+ضمن X bar موجب أو ناقص 2 standard deviation لو
+
+7
+00:00:34,510 --> 00:00:39,750
+النقاط اللي شفناها على المنحنة كانت محصورة بين الـ
+
+8
+00:00:39,750 --> 00:00:44,310
+X bar الـ mean موجب أو ناقص 2 standard deviation
+
+9
+00:00:44,310 --> 00:00:49,240
+إذن النتائج مقبولةطيب لو لجيت في يوم من الأيام
+
+10
+00:00:49,240 --> 00:00:55,360
+نتيجة outside برة لإتنين standard deviation معناه
+
+11
+00:00:55,360 --> 00:01:00,340
+في عندي مشكلة شو هذه المشكلة؟ error خطأ قد يكون
+
+12
+00:01:00,340 --> 00:01:05,360
+random قد يكون systematic يعني بده حل عشان هيك
+
+13
+00:01:05,360 --> 00:01:10,800
+حطولنا ال Westgard rule اللي هي قواعد Westgard هذه
+
+14
+00:01:10,800 --> 00:01:18,570
+القواعدإذن بتسهّن علينا اكتشاف وين الخطأ في أي يوم
+
+15
+00:01:18,570 --> 00:01:24,050
+حدث خطأ وإيش هو الخطأ اللي صار لما شغلنا الـ
+
+16
+00:01:24,050 --> 00:01:28,710
+Control أول قاعدة، خلّينا نستعرض مع بعض القواعد
+
+17
+00:01:28,710 --> 00:01:34,110
+أول قاعدة اسمها 1.2S تفاجنة S يقصد فيها
+
+18
+00:01:34,110 --> 00:01:40,290
+الـStandard Deviationلو جينا نطبق قاعدة الـ N تمام
+
+19
+00:01:40,290 --> 00:01:45,310
+الـ N قلنا الـ number عدد نتائج الـ control اللي
+
+20
+00:01:45,310 --> 00:01:50,810
+فيها المشكلة هنا كتبلك واحد معناه عدد نتائج الـ
+
+21
+00:01:50,810 --> 00:01:55,410
+control اللي فيها المشكلة نتيجة واحدة اتنين F
+
+22
+00:01:55,410 --> 00:02:01,310
+معناه هذه النتيجة الواحدة outside طلعت برا لإتنين
+
+23
+00:02:01,310 --> 00:02:08,150
+standard deviationإذن لو في يوم من الأيام طلعت أن
+
+24
+00:02:08,150 --> 00:02:12,670
+هذا نص القاعدة 1,2,S في يوم من الأيام لو طلعت
+
+25
+00:02:12,670 --> 00:02:18,410
+نتيجة واحدة outside من نتائج الـcontrol برا لإتنين
+
+26
+00:02:18,410 --> 00:02:24,010
+standard deviation برا، outside، وين برا؟ تعالوا
+
+27
+00:02:24,010 --> 00:02:29,590
+على الرسمة نشوفاتطلعولي في اليوم التاني لو جيتي
+
+28
+00:02:29,590 --> 00:02:35,010
+على اليوم التاني هتلاقي نتيجة الـ Control طلعت برا
+
+29
+00:02:35,010 --> 00:02:41,570
+الموجة بـ 2SD شايفين الموجة بـ 2SD والخط الأصفر
+
+30
+00:02:41,570 --> 00:02:47,600
+فيه فوجه نقطةيعني هي في يوم من الأيام طلعت نتيجة
+
+31
+00:02:47,600 --> 00:02:54,880
+فوق الـ2S دي أو ممكن تطلع تحت السالب 2S دي لو
+
+32
+00:02:54,880 --> 00:02:59,960
+نزلنا تحت، تحت المين، عندي سالب 2S دي أو هذا الخط
+
+33
+00:02:59,960 --> 00:03:07,160
+الأصفر لو النقطة طلعت برضه تحته سواء فوق الموجة 2S
+
+34
+00:03:07,160 --> 00:03:12,780
+أو تحت السالب 2S ما هي outside 2Sأنا لما أحكيكوا
+
+35
+00:03:12,780 --> 00:03:17,880
+outside برا الإتنين S أقصد إما فوق الموجة بإتنين
+
+36
+00:03:17,880 --> 00:03:23,440
+تطلع النقطة أو تحت السالب إتنين تمام؟ بيحكيلي هذه
+
+37
+00:03:23,440 --> 00:03:26,860
+القاعدة a warning rule قاعدة تحذيرية يعني لو
+
+38
+00:03:26,860 --> 00:03:30,720
+طلعتلك نتيجة من نتائج ال control تنطبق عليها هذه
+
+39
+00:03:30,720 --> 00:03:36,350
+القاعدة هذه قاعدة تحذيرية بتحذركthat is violated
+
+40
+00:03:36,350 --> 00:03:40,350
+when a single control observation قيمة واحدة من
+
+41
+00:03:40,350 --> 00:03:45,390
+نتائج الـ control is outside خارج الموجد أو الـ
+
+42
+00:03:45,390 --> 00:03:50,770
+minus لإتنين as limits. This rule warns that a
+
+43
+00:03:50,770 --> 00:03:53,890
+random error أو systematic error may be present in
+
+44
+00:03:53,890 --> 00:03:56,730
+the test system. هذه القاعدة تحذيرية بتقول لك
+
+45
+00:03:56,730 --> 00:04:02,570
+انتبه، ممكن في الأيام الجاية يصير عندك random
+
+46
+00:04:02,570 --> 00:04:06,760
+error أو systematic error.إذا لو ظهرت عندي هذه
+
+47
+00:04:06,760 --> 00:04:11,600
+القاعدة في نتائج الـ Control إنه خد حذرك لكن هذه
+
+48
+00:04:11,600 --> 00:04:15,460
+القاعدة لا تعتبر rejection rule قاعدة يعني .. يعني
+
+49
+00:04:15,460 --> 00:04:18,500
+إيش يعني rejection؟ رفض إنه أنا لو طلعت هذه
+
+50
+00:04:18,500 --> 00:04:22,200
+النتيجة معي أو قيمة من القيم برا الإتنين أسمها،
+
+51
+00:04:22,200 --> 00:04:28,400
+برفضها عادي بقبلها، لكن بدي أخد الحيطة و الحذر و
+
+52
+00:04:28,400 --> 00:04:36,460
+أنتبه في الخطوات الجايةالقاعدة التانية 1 3 F يعني
+
+53
+00:04:36,460 --> 00:04:40,960
+في يوم من الأيام ظهرت نتيجة واحدة من نتائج
+
+54
+00:04:40,960 --> 00:04:45,860
+الـcontrol outside برا التلاتة standard deviation
+
+55
+00:04:45,860 --> 00:04:51,860
+إما فوق الموجة، إما فوق خط الموجة بتلاتة F ديأو
+
+56
+00:04:51,860 --> 00:04:57,100
+تحت خط السالب تلاتة S دي تعالوا نشوف على الرسمة في
+
+57
+00:04:57,100 --> 00:05:01,820
+اليوم السادس زهرت النقطة لو طلعنا فوق وشوفنا
+
+58
+00:05:01,820 --> 00:05:07,960
+النتيجة زهرت فوق الموجة بتلاتة S أو لو زهرت تحت خط
+
+59
+00:05:07,960 --> 00:05:14,080
+السالب تلاتة S برضه صح المهم المهم برا التلاتة S
+
+60
+00:05:14,970 --> 00:05:21,170
+إذاً هذه النتيجة وهذه القاعدة اسمها قاعدة 1.3S one
+
+61
+00:05:21,170 --> 00:05:25,610
+equality control result outside موجب أو ناقص
+
+62
+00:05:25,610 --> 00:05:29,530
+التلاتة standard deviation وهذه القاعدة تعتبر
+
+63
+00:05:29,530 --> 00:05:33,590
+rejection rule قاعدة رفض يعني لو ظهرت نتيجة من
+
+64
+00:05:33,590 --> 00:05:37,930
+نتائج ال control برة التلاتة S دي برفضها وبوجه
+
+65
+00:05:37,930 --> 00:05:42,710
+الشغل ولازم أشوف وين المشكلة اللي جعلت هذه القيمة
+
+66
+00:05:42,710 --> 00:05:49,450
+خاطئةوجود هذه القاعدة ينذر بوجود إما Unacceptable
+
+67
+00:05:49,450 --> 00:05:54,110
+Random Error خطأ عشوائي غير مقبول أو بداية لـ
+
+68
+00:05:54,110 --> 00:05:59,370
+Systematic Error بس الأرجح إنه لو ظهرت قاعدة الـ 1
+
+69
+00:05:59,370 --> 00:06:03,710
+تلاتة أسف نتائج الـ Control إذا فاندي Random Error
+
+70
+00:06:03,710 --> 00:06:05,690
+الأرجح Random Error
+
+71
+00:06:08,460 --> 00:06:14,380
+نيجي للقاعدة التالتة القاعدة التالتة هي 2 2 S يعني
+
+72
+00:06:14,380 --> 00:06:21,460
+في يومين متتاليان ظهرت عندي نتجتين من نتائج الـ
+
+73
+00:06:21,460 --> 00:06:28,180
+Control هدول النتجتين ظهروا outside الـ 2S إما فوق
+
+74
+00:06:28,180 --> 00:06:35,790
+الموجب 2 أو تحت خط السالب 2بنفس الاتجاه تعالى نشوف
+
+75
+00:06:35,790 --> 00:06:40,890
+الرسمة و بعدين نقرأ ال slide هي لو جينا على الرسمة
+
+76
+00:06:40,890 --> 00:06:44,750
+في اليوم التاني و اليوم التالت هنشوف في اليوم
+
+77
+00:06:44,750 --> 00:06:51,150
+التاني ظهرت النقطة الصفراء فوق خط الموجة بـ2S وفي
+
+78
+00:06:51,150 --> 00:06:54,870
+اليوم التالت ظهرت نقطة صفراء نتيجة من نتائج
+
+79
+00:06:54,870 --> 00:07:00,730
+الـcontrol برضه فوق الموجة بـ2Sيعني في يومين
+
+80
+00:07:00,730 --> 00:07:06,670
+متتاليين ظهروا عنده نتجتين من نتائج الـ Control
+
+81
+00:07:06,670 --> 00:07:13,310
+فوق خط الموجة بـ 2 أو ممكن يظهروا تحت خط السالب 2S
+
+82
+00:07:13,310 --> 00:07:19,990
+إذا بنتبق عليهم قاعدة 2 2S هذه القاعدة rejection
+
+83
+00:07:19,990 --> 00:07:26,090
+rule قاعدة رفض يعني لو ظهروا نتجتين outside 2Sفي
+
+84
+00:07:26,090 --> 00:07:30,150
+يومين متتاليين معناه في عندي مشكلة وبدي أحلها
+
+85
+00:07:30,150 --> 00:07:35,310
+وعالأغلب بتكون المشكلة systematic error عالأغلب
+
+86
+00:07:35,310 --> 00:07:39,010
+بتكون المشكلة systematic error this rule
+
+87
+00:07:39,010 --> 00:07:44,330
+identifies systematic error only حكيناthe criteria
+
+88
+00:07:44,330 --> 00:07:48,730
+for this rule ايش نص القاعدة؟ two consecutive
+
+89
+00:07:48,730 --> 00:07:53,550
+equality control results يعني نتجتين من نتائج ال
+
+90
+00:07:53,550 --> 00:07:58,870
+control في يومين متتالين كلمة consecutive متتالين
+
+91
+00:07:59,990 --> 00:08:05,430
+طلع greater than outside يعني الأتنين S on the
+
+92
+00:08:05,430 --> 00:08:09,770
+same side of the mean تمام؟ إن النتجتين مع بعض
+
+93
+00:08:09,770 --> 00:08:14,750
+التنتين بتطلع فوق الأتنين F أو تحت خط الثالب أتنين
+
+94
+00:08:14,750 --> 00:08:20,610
+Fأما بجية الجملة على الـ slide التانية هنشرحها or
+
+95
+00:08:20,610 --> 00:08:25,130
+both controls in the same run exceeds موجب أو ناقص
+
+96
+00:08:25,130 --> 00:08:30,690
+2 SD على ال slide التانية patient results cannot
+
+97
+00:08:30,690 --> 00:08:34,580
+be reported لما بظهروا عندى نتائج ال controlتنتين
+
+98
+00:08:34,580 --> 00:08:39,500
+برا الأتنين S ممنوع أحط عينات المرضى في الجهاز
+
+99
+00:08:39,500 --> 00:08:44,300
+وأشتغلهم لازم أحل مشكلة ال control بعدين نشبك
+
+100
+00:08:44,300 --> 00:08:48,820
+عينات المرضى وهذا الاشي بحتاج لـ Corrective Action
+
+101
+00:08:48,820 --> 00:08:52,620
+أكيد بحتاج أني أنا حكيتلكوا عندي Systematic Error
+
+102
+00:08:52,620 --> 00:08:58,080
+يعني لازم أشوف حل لمشكلة الـ Systematic Error ونحل
+
+103
+00:08:58,080 --> 00:09:04,820
+الخطأخلونا نحكي عن الرسمة نشوف الرسمة اللي تحت
+
+104
+00:09:04,820 --> 00:09:09,880
+بعدين نطلع على الرسمة اللي فوق الرسمة اللي تحت لو
+
+105
+00:09:09,880 --> 00:09:15,860
+جيته على اليوم الرابع هتلاقي النقطة الخضرة فوق خط
+
+106
+00:09:15,860 --> 00:09:22,520
+الموجة بـ2Sوبرضه في اليوم الخامس برضه كمان نقطة
+
+107
+00:09:22,520 --> 00:09:28,540
+خضرة فوق الخط الموجة بـ 2S إذا في يومين متتاليين
+
+108
+00:09:28,540 --> 00:09:33,960
+ظهروا عندى نتجتين فوق الموجة بـ 2S إذا هذه قاعدة
+
+109
+00:09:33,960 --> 00:09:40,810
+الـ 22S لو انتبهتيتحت كتبلك Level 1 ولون أخضر
+
+110
+00:09:40,810 --> 00:09:45,770
+Level 1 يقصد فيه الـ Normal Control يقصد فيه أنه
+
+111
+00:09:45,770 --> 00:09:51,350
+أنا بس مشيت Normal Control بيحكيلي لو أنتي مشيتي
+
+112
+00:09:51,350 --> 00:09:55,070
+الـ Two Control يعني الـ Normal Control و الـ
+
+113
+00:09:55,070 --> 00:10:00,510
+Abnormal Control Level 1 و Level 2 انشوف الرسمة
+
+114
+00:10:00,510 --> 00:10:03,410
+اللي فوق إذا الرسمة اللي تحت هذه كلنا عارفينها
+
+115
+00:10:03,410 --> 00:10:08,410
+والقاعدة عاديةإذا مشيت أنا control واحد هيك الكلام
+
+116
+00:10:08,410 --> 00:10:12,750
+صحيح طيب لو أنا مشيت to control level واحد و level
+
+117
+00:10:12,750 --> 00:10:17,270
+اتنين انشوف الرسمة اللي فوق الرسمة اللي فوق بتقول
+
+118
+00:10:17,270 --> 00:10:22,770
+لي في يوم واحد أنا مشيت controlينnormal control و
+
+119
+00:10:22,770 --> 00:10:27,910
+abnormal control يعني هيطلعوا عندى نتجتين لو طلعوا
+
+120
+00:10:27,910 --> 00:10:34,310
+النتجتين outside الـ 2S سواء أعلى من موجب الـ 2 أو
+
+121
+00:10:34,310 --> 00:10:39,810
+تحت خط السالب 2 إذا أيضا تنطبق عليها قاعدة الـ 2
+
+122
+00:10:39,810 --> 00:10:45,090
+2S هي في اليوم التالتمشيت Normal و Abnormal
+
+123
+00:10:45,090 --> 00:10:50,850
+Control والنتشتين مع بعض طلعوا تحت خط السالب 2 زي
+
+124
+00:10:50,850 --> 00:10:56,150
+ما انتوا شايفين أو اذا طلعوا فوق خط موجب 2، فوق خط
+
+125
+00:10:56,150 --> 00:11:00,970
+الموجب 2، برضه صح، اذا يا اما بتقولي في يومين
+
+126
+00:11:00,970 --> 00:11:07,800
+متتالين ظهرت نتشتين أو اما الواحد يقول انهفي يوم
+
+127
+00:11:07,800 --> 00:11:11,880
+واحد أنا اشتغلت Controllain يعني في اليوم الواحد
+
+128
+00:11:11,880 --> 00:11:19,380
+ظهرت عندى نتج تان تمام القاعدة الرابعة اسمها الـ
+
+129
+00:11:19,380 --> 00:11:26,120
+R4S تعالى نشوف ايش هذه القاعدة على شو بتنص القاعدة
+
+130
+00:11:26,120 --> 00:11:32,520
+R4S بحكيلي انه تعالى نشوفها على الرسمة و بعدين
+
+131
+00:11:32,520 --> 00:11:38,260
+نرجع نشوف على ايش بتنص من الرسمة هنفهملو جيت على
+
+132
+00:11:38,260 --> 00:11:43,260
+اليوم الخامس والسادس معي على الرسم اللي على اليمين
+
+133
+00:11:43,260 --> 00:11:49,160
+لو جينا على اليوم الخامس هتلاحظي طلعت نقطة صفراء
+
+134
+00:11:49,160 --> 00:11:55,210
+نتيجة الـ Control تحت خط السالب 2S تمامفي اليوم
+
+135
+00:11:55,210 --> 00:12:00,270
+السادس لو جيت هلاقي طلعت نتيجة الـ Control النقطة
+
+136
+00:12:00,270 --> 00:12:07,670
+الصفراء فوق خط الموجب 2S يعني بقدر أستنتج القاعدة
+
+137
+00:12:07,670 --> 00:12:15,420
+تاعة الـ R4S في يومين متتالينطلع عندى نتجتين لـ
+
+138
+00:12:15,420 --> 00:12:20,920
+Control نتيجة من النتائج طلعت تحت السالي بـ 2S
+
+139
+00:12:20,920 --> 00:12:26,980
+ونتيجة الـ نتيجة الأخرى طلعت فوق خط الموجة بـ 2S
+
+140
+00:12:26,980 --> 00:12:32,780
+يعني واحدة فوق وواحدة تحت عكس الـ 2 2S الـ 2 2S
+
+141
+00:12:32,780 --> 00:12:38,940
+تنتل يا إما معبعة فوق يا إما معبعة تحت لكن الـ R4S
+
+142
+00:12:38,940 --> 00:12:45,390
+نتيجةتحت السلب 2 ونتيجة فوق الموجب 2 هذا نص
+
+143
+00:12:45,390 --> 00:12:50,650
+القاعدة القاعدة يا جماعة rejection rule يعني لو
+
+144
+00:12:50,650 --> 00:12:54,470
+ظهرت هذه القاعدة عندى في نتائج ال control برفض
+
+145
+00:12:54,470 --> 00:12:59,910
+نتيجة ال control معناه بينزر لوجود random error
+
+146
+00:12:59,910 --> 00:13:05,650
+خطأ عشوائي وبدنا انحله تمام وجود قاعدة ال R4S
+
+147
+00:13:05,650 --> 00:13:10,420
+معناه عندنا خطأ عشوائي وبدنا انحلهتعالى نشوف
+
+148
+00:13:10,420 --> 00:13:16,560
+الرسمة اللي على اليسار بدنا نقرأ تحت level 1 يعني
+
+149
+00:13:16,560 --> 00:13:21,400
+normal control level 2 يعني abnormal control يعني
+
+150
+00:13:21,400 --> 00:13:27,160
+في اليوم الواحد في اليوم التالت مشة controlين مشة
+
+151
+00:13:27,160 --> 00:13:31,960
+ال normal وال abnormal نتيجة من النتائج نتيجة
+
+152
+00:13:31,960 --> 00:13:37,040
+اللون الأخضر ال normal control طلعت فوق الموجب 2S
+
+153
+00:13:37,460 --> 00:13:42,460
+ونتيجة الـ Level 2 الـ Abnormal Control طلعت تحت
+
+154
+00:13:42,460 --> 00:13:48,900
+السالب 2S برضه تنطبق عليها قاعدة الـ R4S في يوم
+
+155
+00:13:48,900 --> 00:13:54,620
+واحد مشيت Control 2 أو في يومينوتتاليين في كل يوم
+
+156
+00:13:54,620 --> 00:13:58,820
+نتيجة طلعت واحدة طلعت تحت السلب اتنين واحدة طلعت
+
+157
+00:13:58,820 --> 00:14:05,600
+موجب اتنين طيب لو ارجعنا للقاعدة R4S الاربعة
+
+158
+00:14:05,600 --> 00:14:12,510
+standard deviation من وين جايين؟ جايين منالفرق بين
+
+159
+00:14:12,510 --> 00:14:17,550
+النقطتين النقطة اللي فوق والنقطة اللي تحت نرجع
+
+160
+00:14:17,550 --> 00:14:24,010
+برضه على الرسم اللي على اليمين النقطة اللي فوق هي
+
+161
+00:14:24,010 --> 00:14:28,550
+موجب اتنين صح ولا لأ انهاطالع فوق الموجة بتنين
+
+162
+00:14:28,550 --> 00:14:33,150
+والنقطة اللي تحت طالعة تحت السالي بتنين لو حكيتلك
+
+163
+00:14:33,150 --> 00:14:37,610
+هتيل الفرق بين النقطين يعني طرح يعني هتطرح النقطة
+
+164
+00:14:37,610 --> 00:14:42,230
+اللي فوق من النقطة اللي تحت يعني هتحكي موجة بتنين
+
+165
+00:14:42,230 --> 00:14:50,730
+ناقص بدي أطرحبنحكي شو موجة بتنين ناقص سالب اتنين و
+
+166
+00:14:50,730 --> 00:14:56,170
+هي ساوي أربعة كيف النقطة اللي فوق موجة بتنين بدي
+
+167
+00:14:56,170 --> 00:15:00,630
+أطرحها من النقطة اللي تحت يعني موجة بتنين ناقص
+
+168
+00:15:00,630 --> 00:15:06,650
+سالب اتنين فبطلع الفرق بين النقطتين أربعة standard
+
+169
+00:15:06,650 --> 00:15:12,290
+deviationنقرأ الكلام، this rule identifies random
+
+170
+00:15:12,290 --> 00:15:16,150
+error only حكينا وجودها معناه random error one
+
+171
+00:15:16,150 --> 00:15:21,870
+control exceeds the mean by minus 2SD نتيجة واحدة
+
+172
+00:15:21,870 --> 00:15:26,030
+طلعت تحت السالب 2 and the other control exceeds
+
+173
+00:15:26,030 --> 00:15:32,320
+the mean by plus 2SD واحدة فوق الـ2SDالـ
+
+174
+00:15:32,320 --> 00:15:35,260
+difference between the two results will therefore
+
+175
+00:15:35,260 --> 00:15:39,880
+exceed 4SD الفرق بين النقطين أربعة standard
+
+176
+00:15:39,880 --> 00:15:46,610
+deviation هذا المطلوب من هذه الـ slideالقاعدة
+
+177
+00:15:46,610 --> 00:15:53,650
+الخامسة أربعة واحد S بفهم إنه في أربع أيام متتالية
+
+178
+00:15:53,650 --> 00:15:59,450
+ظهرت عندي أربع نتائج من نتائج الـ Control كلهم
+
+179
+00:15:59,450 --> 00:16:05,210
+outside الواحد standard deviation كلهم إما أعلى من
+
+180
+00:16:05,210 --> 00:16:11,250
+موجة بواحد أو كلهم تحت خط السالب واحد SD تعالوا
+
+181
+00:16:11,250 --> 00:16:16,050
+نشوف الرسمةفي اليوم، ركزوا معي السابع والتاني
+
+182
+00:16:16,050 --> 00:16:20,870
+والتاسع والعاشر، تمام؟ في اليوم السابع، النتيجة
+
+183
+00:16:20,870 --> 00:16:26,010
+طلعت هي المين وهي سالب واحد أس اللون الأخضر، الخط
+
+184
+00:16:26,010 --> 00:16:31,070
+اللي لونه أخضر في اليوم السابع، النتيجة طلعت تحت
+
+185
+00:16:31,070 --> 00:16:34,510
+السالب واحد، هي اللون الأخضر وهي النقطة الخضرة تحت
+
+186
+00:16:34,510 --> 00:16:38,910
+السالب واحد وفي اليوم التامن، أيضًا النتيجة تحت
+
+187
+00:16:38,910 --> 00:16:43,010
+السالب واحد، okay هي على الخط، بس هي تحتفي اليوم
+
+188
+00:16:43,010 --> 00:16:47,170
+التاسع أيضًا النتيجة تحت السالب واحد وفي اليوم
+
+189
+00:16:47,170 --> 00:16:51,990
+العاشر برضه النتيجة تحت السالب واحد أو ممكن الأربع
+
+190
+00:16:51,990 --> 00:16:57,130
+نقاط هدول كلهم يطلعوا فوق خط الموجة بواحد أس هي
+
+191
+00:16:57,130 --> 00:17:01,740
+موجة بواحد أس بيطلعوا فوقهيا تحت السالب واحد يا
+
+192
+00:17:01,740 --> 00:17:07,220
+فوق الموجب واحد هذه بحكي عنها قاعدة 41S هذه
+
+193
+00:17:07,220 --> 00:17:11,540
+القاعدة rejection rule وجودها مرفوض ولو ان وجدت
+
+194
+00:17:11,540 --> 00:17:16,680
+إذا تنذر له وجود systematic error يجب حله سريعا،
+
+195
+00:17:16,680 --> 00:17:21,430
+تمام؟نقرأ The criteria which must be met to
+
+196
+00:17:21,430 --> 00:17:25,770
+manifest this rule are بتنص على four consecutive
+
+197
+00:17:25,770 --> 00:17:29,550
+equality control result for one level of control
+
+198
+00:17:29,550 --> 00:17:34,950
+are outside الموجب أو ناقص الواحد SD on the same
+
+199
+00:17:34,950 --> 00:17:39,740
+side of the mean أربع نتائج في أيام متتاليةطلعوا
+
+200
+00:17:39,740 --> 00:17:45,040
+خارج الـ 1S إما فوق الموجة بـ 1 أو تحت السالب 1
+
+201
+00:17:45,040 --> 00:17:49,440
+إذا نشيت نوع واحد من الـ Control هذه الرسمة لما
+
+202
+00:17:49,440 --> 00:17:53,660
+بمشي يا Normal Control يا Abnormal Control أما
+
+203
+00:17:53,660 --> 00:17:58,420
+النقطة الأخرى، على الـ slide التانية هنشرحها قلنا
+
+204
+00:17:58,420 --> 00:18:03,380
+هذه القاعدة تكشف الـ Systematic Error وهي قاعدة
+
+205
+00:18:03,380 --> 00:18:09,280
+Rejected Rule مرفوضةنيجي على هذه الـ slide تعالوا
+
+206
+00:18:09,280 --> 00:18:13,460
+معي الرسم اللي فوق امشي فقط level واحد يعني
+
+207
+00:18:13,460 --> 00:18:18,540
+control واحد يعني انتبهوا اليوم التالت والرابع
+
+208
+00:18:18,540 --> 00:18:24,610
+والخامس والسادس هذه أربع أيام متتاليةتمام اليوم
+
+209
+00:18:24,610 --> 00:18:30,230
+التالت والرابع والخامس والسادس كل النتائج طلعت تحت
+
+210
+00:18:30,230 --> 00:18:37,530
+خط السالب واحد S إذا هذه قاعدة أربعة واحد S لكن لو
+
+211
+00:18:37,530 --> 00:18:43,300
+اشتغلت Normal و Abnormal Control في نفس اليومlevel
+
+212
+00:18:43,300 --> 00:18:48,420
+واحد و level اتنين يعني هتحكي في اليوم التاني
+
+213
+00:18:48,420 --> 00:18:52,600
+انتبهوا على الرسم اللي تحت في اليوم التاني اشتغل
+
+214
+00:18:52,600 --> 00:18:57,860
+controlين normal و abnormal control اللون الأخضر و
+
+215
+00:18:57,860 --> 00:19:04,920
+ال move اللي فوق بعد تمام؟هدولا النقطتين طلعوا فوق
+
+216
+00:19:04,920 --> 00:19:11,000
+الموجة بـ 1S تمام، يعني برا الـ 1S، okay في اليوم
+
+217
+00:19:11,000 --> 00:19:15,480
+التالت برضه اشتغل Normal و Abnormal Control و
+
+218
+00:19:15,480 --> 00:19:21,140
+النتيجتين برضه الأخضر والموف طلعوا برضه فوق الموجة
+
+219
+00:19:21,140 --> 00:19:25,980
+بـ 1S إذا لما بدك تشتغلي Controlling في نفس اليوم
+
+220
+00:19:26,210 --> 00:19:31,090
+بتسيري تحكي في يومين متتاليين طلعوا عندي أربع
+
+221
+00:19:31,090 --> 00:19:39,070
+نتائج فوق الـ1S، تمام؟ سواء فوق الموجب 1 أو الأربع
+
+222
+00:19:39,070 --> 00:19:45,190
+نقاط هذه طلعت تحت السلب 1 إذا لو مشيت Ctrl 1، بحكي
+
+223
+00:19:45,190 --> 00:19:49,270
+في أربع أيام متتالية، طلعوا عندي أربع نتائجطيب لو
+
+224
+00:19:49,270 --> 00:19:54,570
+في اليوم الواحد مشيت نتج تان هقول في يومين متتالين
+
+225
+00:19:54,570 --> 00:19:59,110
+طلع عندي أربع نتاج لأنه فعليا في اليوم الواحد
+
+226
+00:19:59,110 --> 00:20:06,990
+اشتغل Controlling وبالتالي طلّع نتج تانعشرة X bar
+
+227
+00:20:06,990 --> 00:20:13,310
+عشرة X bar يعني في عشر أيام متتالية ظهرت عندي عشر
+
+228
+00:20:13,310 --> 00:20:19,870
+نتائج هذه العشر نتائج إما ظهرت كلها فوق خط المين
+
+229
+00:20:19,870 --> 00:20:24,710
+أو تحت خط المين المين هو الـ X bar هو الوسط
+
+230
+00:20:24,710 --> 00:20:31,400
+الحسابي تعالوا شوفوا من اليوم الأول لليوم العاشرفي
+
+231
+00:20:31,400 --> 00:20:35,160
+اليوم الأول النقطة هي خط المين اللي بالمنتصف اللي
+
+232
+00:20:35,160 --> 00:20:39,980
+لونه أسود في اليوم الأول النقطة فوق خط المين اليوم
+
+233
+00:20:39,980 --> 00:20:44,020
+التاني النقطة برضه فوق خط المين من اليوم الأول
+
+234
+00:20:44,020 --> 00:20:48,340
+لليوم العاشر لو شفتوا النقاط كلها طالع فوق المين
+
+235
+00:20:48,340 --> 00:20:53,660
+مافيش ولا نقطة تحت هذه قاعدة اسمها 10XPAR هذه
+
+236
+00:20:53,660 --> 00:20:58,120
+القاعدة إن وجدت في نتائج الـcontrol بحكي عنها هي
+
+237
+00:20:58,120 --> 00:21:03,730
+rejected rule قاعدة مرفوضةوإن وجدت بيتنبهني إن في
+
+238
+00:21:03,730 --> 00:21:08,810
+عندي Systematic Error موجود في عندنا أخطاء منهجية
+
+239
+00:21:08,810 --> 00:21:14,230
+موجودة، تمام؟ These rules are violated when there
+
+240
+00:21:14,230 --> 00:21:18,750
+are 10 consecutive quality control results for one
+
+241
+00:21:18,750 --> 00:21:23,410
+level of control are on one side of domain يعني لو
+
+242
+00:21:23,410 --> 00:21:26,410
+أنا اشتغلت هذه الرسمة اللي عندي على control واحد
+
+243
+00:21:26,410 --> 00:21:30,610
+سواء normal أو abnormal، اشتغلت عليهطلعت عشر نتائج
+
+244
+00:21:30,610 --> 00:21:34,550
+في عشر أيام متتالية كلها فوق المين أو كلها تحت
+
+245
+00:21:34,550 --> 00:21:39,730
+المين تمام النقطة التانية هنحكي فيها على ال slide
+
+246
+00:21:39,730 --> 00:21:44,130
+اللي بعدها هذه القاعدة تفاجنا الـ Systematic Error
+
+247
+00:21:44,130 --> 00:21:50,990
+وRejected Rule تماملو انتبهنا على الرسمة اللي فوق
+
+248
+00:21:50,990 --> 00:21:56,910
+ماشية فقط Normal Control هي من اليوم الأول لليوم
+
+249
+00:21:56,910 --> 00:22:01,750
+العاشر لو انتبهتوا على النتائج وهي الـMean الـM هو
+
+250
+00:22:01,750 --> 00:22:06,200
+الـMean، هي خط الـMeanالعشر نتائج كلها تحت خط
+
+251
+00:22:06,200 --> 00:22:10,200
+المين الرسمة اللي جابلها كانت العشر نتائج كلها فوق
+
+252
+00:22:10,200 --> 00:22:15,820
+خط المين صحيح هذا كله قاعدة اسمها قاعدة العشرة X
+
+253
+00:22:15,820 --> 00:22:20,260
+bar طيب لو أنا في اليوم الواحد مشيت controlين
+
+254
+00:22:20,260 --> 00:22:24,460
+normal و abnormal يعني في اليوم الواحد حصلت على
+
+255
+00:22:24,460 --> 00:22:30,850
+نتجتين تمام؟ نشوف الرسمة اللي تحتفي اليوم الأول
+
+256
+00:22:30,850 --> 00:22:35,230
+اشتغل Ctrl 2 وبالتالي حصل على نتاج 2 اللون الـ
+
+257
+00:22:35,230 --> 00:22:38,830
+mauve والأخضر في اليوم التاني اشتغل برضه Ctrl 2
+
+258
+00:22:38,830 --> 00:22:44,770
+وفي اليوم التالت والرابع والخامس إذا خلال خمس أيام
+
+259
+00:22:44,770 --> 00:22:50,150
+متتالية في كل يوم اشتغل Ctrl 2 وبالتالي حصل على
+
+260
+00:22:50,150 --> 00:22:56,810
+نتاج 2 فلو عدينا النتائج هيطلع عشر نتائج خلال خمس
+
+261
+00:22:56,810 --> 00:23:03,250
+أياملأنه كل يوم حصل على نتاشتين فخلال خمس أيام كان
+
+262
+00:23:03,250 --> 00:23:08,650
+حاصل على عشر نتائج والعشر نتائج لو انتبهتوا كلهم
+
+263
+00:23:08,650 --> 00:23:13,210
+فوق خط المين هاي الـM هي المين والعشر نتائج كلها
+
+264
+00:23:13,210 --> 00:23:17,550
+فوق خط المين فهذه قاعدة تسمى العشرة X bar يعني
+
+265
+00:23:17,550 --> 00:23:23,580
+اللي بدي أعرفه سواء انت اشتغلتي Ctrl 1أو اشتغل كـ
+
+266
+00:23:23,580 --> 00:23:30,330
+Controllant بنفس اليوم تنطبق عليهم نفس القاعدةهنا
+
+267
+00:23:30,330 --> 00:23:35,410
+فقط يعني نظام مراجعة هو عامل مراجعة بس أربع قواعد
+
+268
+00:23:35,410 --> 00:23:39,810
+الواحد تلاتة أس اتفجنا نتيجة واحدة من نتائج ال
+
+269
+00:23:39,810 --> 00:23:43,690
+control برا التلاتة أس هنا حاطط النقطة اللي
+
+270
+00:23:43,690 --> 00:23:48,570
+بالدائرة تحت السالد تلاتة أس لو طلعتلكم إياها فوق
+
+271
+00:23:48,570 --> 00:23:53,440
+الموجة بتلاتة أس برضه صح تمام؟القاعدة التانية
+
+272
+00:23:53,440 --> 00:23:57,600
+اتنين اتنين أس في يومين متتاليين اليوم التاني
+
+273
+00:23:57,600 --> 00:24:02,580
+والتالت طلعت عندي نتجتين فوق الموجة باتنين شفتوا؟
+
+274
+00:24:02,580 --> 00:24:06,080
+هي الموجة باتنين وهي النقطتين معلم عليهم أو لو
+
+275
+00:24:06,080 --> 00:24:10,660
+حطيتلكم النقطتين تحت السالب اتنين أس تحت خط السالب
+
+276
+00:24:10,660 --> 00:24:18,100
+اتنين أس برضه صحتمام القاعدة التالتة الـ R4S قلنا
+
+277
+00:24:18,100 --> 00:24:25,600
+إنه في اليوم الخامس مخلي نتيجة تحت السالب 2 تحت خط
+
+278
+00:24:25,600 --> 00:24:30,560
+السالب 2 وفي اليوم السادس مخلي النتيجة فوق الموجة
+
+279
+00:24:30,560 --> 00:24:35,040
+2 إذا واحدة تحت السالب 2 وواحدة فوق الموجة 2 إذا
+
+280
+00:24:35,040 --> 00:24:42,320
+هذه قاعدة الـ R4S تمامأخر إشي أربعة واحد يعني أربع
+
+281
+00:24:42,320 --> 00:24:48,360
+أيام متتالية اليوم السابع التامن التاسع العاشر هاي
+
+282
+00:24:48,360 --> 00:24:53,140
+في اليوم السابع نتيجتي تحت السالب واحد هاي خط
+
+283
+00:24:53,140 --> 00:24:58,260
+السالب واحد اللي لونه أخضر هاي تحته في اليوم
+
+284
+00:24:58,260 --> 00:25:03,700
+التامن في خطأ في النقطة بطلب منكم تمسحوا النقطة
+
+285
+00:25:03,700 --> 00:25:09,900
+هذه اللي فوقنقطة رقم تمانية واتنزلوها تحت السالب
+
+286
+00:25:09,900 --> 00:25:14,100
+واحد انتوا بالملزمة هتمسحوها واتنزليها تحت السالب
+
+287
+00:25:14,100 --> 00:25:17,460
+واحد لإنها لازم تكون تحت السالب واحد في اليوم
+
+288
+00:25:17,460 --> 00:25:21,620
+التاسع النقطة هيها تحت السالب واحد تحت خط السالب
+
+289
+00:25:21,620 --> 00:25:25,500
+واحد في اليوم العاشر برضه نقطة تحت خط السالب واحد
+
+290
+00:25:25,500 --> 00:25:32,440
+إذا انت تنطبق عليهم قاعدة 41Sعندي فيه شغلات أخطأ
+
+291
+00:25:32,440 --> 00:25:37,660
+ممكن أنا يعني لما أرسم نتائج الـ Control أن تبهلها
+
+292
+00:25:37,660 --> 00:25:42,880
+وأحكي والله هنا فيه خطأ عندي فيه مشكلة تسمى مشكلة
+
+293
+00:25:42,880 --> 00:25:48,300
+الـ Shift، تمام؟ Shift معناها تنزاح القيم لجهة
+
+294
+00:25:48,300 --> 00:25:53,470
+معينة، تمام؟نشوف شو تعريف الـ Shift الـ Shift is a
+
+295
+00:25:53,470 --> 00:25:58,030
+sudden consistent change in values in either side
+
+296
+00:25:58,030 --> 00:26:02,930
+of the mean بكل بساطة بتشوفي مجموعة من نتائج الـ
+
+297
+00:26:02,930 --> 00:26:07,690
+control كلها جاية إما كلها فوق الـ mean أو كلها
+
+298
+00:26:07,690 --> 00:26:11,290
+تحت الـ mean مش كل النتائج يعني بتلاقيلك مثلا عشر
+
+299
+00:26:11,290 --> 00:26:17,070
+نتائج كلهم جايين فوق الـ meanأو عشر نتائج كلهم تحت
+
+300
+00:26:17,070 --> 00:26:22,210
+الـ Main يعني بشكل مبسط مافي Distribution لنتائج
+
+301
+00:26:22,210 --> 00:26:26,330
+الـ Control على الـ Curve يفترض النتائج ستتوزع جزء
+
+302
+00:26:26,330 --> 00:26:30,550
+منها يطلع فوق الـ Main وجزء منها تحت الـ Main لكن
+
+303
+00:26:30,550 --> 00:26:34,770
+في الـ Shift بلاجة في انزياح يعني أن القيم بتنزاح
+
+304
+00:26:34,770 --> 00:26:41,010
+تنزاح لجهة معينة من الـ Main إما فوقه أو تحتهتمام؟
+
+305
+00:26:41,010 --> 00:26:45,890
+Quality control data results are distributed on
+
+306
+00:26:45,890 --> 00:26:51,030
+one side of the meme for 6 ل7 consecutive days
+
+307
+00:26:51,030 --> 00:26:58,710
+يعني لو لجيتيخلال ست لسبع أيام متتالية يعني سبع
+
+308
+00:26:58,710 --> 00:27:04,130
+أيام متتالية لجيت في السبع أيام سبع نتائج كانت
+
+309
+00:27:04,130 --> 00:27:08,570
+كلها فوق المين أو كلها تحت المين بحكي والله عندي
+
+310
+00:27:08,570 --> 00:27:13,490
+مشكلة shift في النتائج عندي نتائج بتنزح إما كلها
+
+311
+00:27:13,490 --> 00:27:18,710
+فوق أو تحت وهذه مشكلة، تمام؟هذا بيسموه الـ Shift
+
+312
+00:27:18,710 --> 00:27:24,650
+لو جينا على الرسمة شوفولي من اليوم العاشر لليوم
+
+313
+00:27:24,650 --> 00:27:30,710
+التلاتين من اليوم العاشر لليوم التلاتين لو جيت على
+
+314
+00:27:30,710 --> 00:27:37,250
+ال X bar خط المين الموف هذا وجسمته هي انجسم انتبهي
+
+315
+00:27:37,250 --> 00:27:42,990
+من اليوم العاشر لليوم التلاتين كل النقاط فوق خط
+
+316
+00:27:42,990 --> 00:27:48,060
+المينكل النقاط فوق خط المين مافيش ولا نقطة نازلة
+
+317
+00:27:48,060 --> 00:27:55,450
+تحت معناه في عندي shift في إزاحة للقيم تمام؟أما
+
+318
+00:27:55,450 --> 00:28:00,650
+بالنسبة لمشكلة أخرى ممكن نشوفها هي الـ Trend الـ
+
+319
+00:28:00,650 --> 00:28:04,230
+Trend إيش تعريفه؟ is a gradual decrease or
+
+320
+00:28:04,230 --> 00:28:08,090
+increase in the values in either side of the mean
+
+321
+00:28:08,090 --> 00:28:15,830
+بنشوف ذيادة أو نقصان تدريجي في القيم كيف؟ مثلا
+
+322
+00:28:15,830 --> 00:28:26,260
+تعالوا انتبهوا معيمن اليوم العاشر لليوم العشرين من
+
+323
+00:28:26,260 --> 00:28:32,220
+اليوم العاشر لليوم العشرين ايش بتشوفوا القيم القيم
+
+324
+00:28:32,220 --> 00:28:36,680
+جاية من المين وانزل لتحت يعني في عندي gradual
+
+325
+00:28:36,680 --> 00:28:42,040
+decrease بدأت تنزل تحت المين وعمل زي انحضار زي ما
+
+326
+00:28:42,040 --> 00:28:46,020
+احنا شايفين منحضر لتحت هذا بيسموه trend gradual
+
+327
+00:28:46,020 --> 00:28:51,810
+decreaseبشكل تدريجي القيم ماشية كأنها ماشية باتجاه
+
+328
+00:28:51,810 --> 00:28:56,610
+النقصان، تمام؟ أو ممكن لو رسمنا رسمة أخرى أو
+
+329
+00:28:56,610 --> 00:29:02,590
+increase، يعني من من المين نفسه ترسمي خط لفوق،
+
+330
+00:29:02,590 --> 00:29:06,510
+القيم تمشي لفوق، يعني إما هذه خط المين، إما
+
+331
+00:29:06,510 --> 00:29:12,120
+النتائج تلاقيها،من المين ونازلة لتحت بشكل منحدر أو
+
+332
+00:29:12,120 --> 00:29:18,040
+من المين وطالعة لفوق بشكل يعني ترضي القيام طالعة
+
+333
+00:29:18,040 --> 00:29:23,700
+لفوق هذه بيسموها الـ Trend طيب، بحكي للقاعدةخلال
+
+334
+00:29:23,700 --> 00:29:28,500
+سبع أيام لو لجيتي سبع نتائج إما ماشية باتجاه
+
+335
+00:29:28,500 --> 00:29:32,960
+النقصان أو طالعة بالزيادة معناها هذا شكل ال trend
+
+336
+00:29:32,960 --> 00:29:38,360
+كتير مميز إما علاقة تحت لتحت ماشية أو نقاط طالعة
+
+337
+00:29:38,360 --> 00:29:45,870
+لفوق يعني في الزيادة، تمام؟أما بالنسبة للـ
+
+338
+00:29:45,870 --> 00:29:50,950
+dispersion آخر مشكلة معناه التشطط بيحكيلي values
+
+339
+00:29:50,950 --> 00:29:54,510
+maybe within the acceptable range but are
+
+340
+00:29:54,510 --> 00:29:59,490
+uneventfully distributed outside the plus minus
+
+341
+00:29:59,490 --> 00:30:03,950
+واحد S limits ال dispersion لو انت طلعتي على كل
+
+342
+00:30:03,950 --> 00:30:11,030
+نتائج ال control بتكون ضمن ال X bar موجب أو ناقص
+
+343
+00:30:11,030 --> 00:30:17,150
+لتنين SD يعني كل نتائجمقبولة ضمن الـ Range بس وين
+
+344
+00:30:17,150 --> 00:30:22,990
+في مشكلة في تشتت القيم الكتير أو النقاط نتائج الـ
+
+345
+00:30:22,990 --> 00:30:27,570
+Control بعيدة عن الـ Mean و بعيدة عن بعضها البعض
+
+346
+00:30:27,570 --> 00:30:31,130
+في dispersion على الرغم من إنها واجعة في الـ
+
+347
+00:30:31,130 --> 00:30:35,780
+Normal Range إذن بدنا نفهمإن كل القيم موجودة ضمن
+
+348
+00:30:35,780 --> 00:30:41,520
+الـ Normal Range الـ X bar موجب أو –2SD لكن في
+
+349
+00:30:41,520 --> 00:30:47,300
+مشكلة في القيم إنها متناثرة متشتتة بعيدة عن الـ
+
+350
+00:30:47,300 --> 00:30:53,260
+Main السببThis is indicating هذا مؤشر على وجود فقد
+
+351
+00:30:53,260 --> 00:30:57,420
+الـ precision فقد الإحكام والضقة في ال kit اللي
+
+352
+00:30:57,420 --> 00:31:02,060
+أنا بشتغله للفحص أو مشكلة إنه حدث Indic Random
+
+353
+00:31:02,060 --> 00:31:07,100
+Error عمل هذا التشتت سواء المشكلة في ال precision
+
+354
+00:31:07,540 --> 00:31:13,840
+أو هناك زيادة في الـ Random Error في الشغل هذا كله
+
+355
+00:31:13,840 --> 00:31:19,580
+What Cause هذا كله هيؤدي إلى حدوث زيادة في الـ
+
+356
+00:31:19,580 --> 00:31:22,580
+Standard Deviation للقيم لما تيجي تحسبي الـ
+
+357
+00:31:22,580 --> 00:31:26,960
+Standard Deviation بطلع كتير عالي مقدار الانحراف
+
+358
+00:31:28,130 --> 00:31:32,010
+طيب لو مقدار التشتت طلع عالي كتير معناه القيم
+
+359
+00:31:32,010 --> 00:31:36,570
+هتبعد عن الـ mean تمام؟ وبالتالي يصير في
+
+360
+00:31:36,570 --> 00:31:41,630
+dispersion تشتت هذه القيم لو انتبهتي على الرسمة من
+
+361
+00:31:41,630 --> 00:31:48,030
+اليوم الأول لليوم التلاتين كل قيمة محصورة بين الـ
+
+362
+00:31:48,030 --> 00:31:53,290
+X bar موجب أو ناقص لـ2S يعني هي قيمة أو قنتين أو
+
+363
+00:31:53,290 --> 00:31:58,670
+تلاتة فوقلكن لو كنظرة أولى هتحس القيم فيها
+
+364
+00:31:58,670 --> 00:32:03,850
+dispersion فيها تشطط و بعيدة عن المين تمام؟
+
+365
+00:32:03,850 --> 00:32:04,830
+يعطيكوا العافية
+
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/AJ9OpH9yA0U_raw.json b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/AJ9OpH9yA0U_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..250343ad0ea5240ea65588d53d058152b691f316
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/AJ9OpH9yA0U_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2580, "start": 1.1, "end": 25.8, "text": "هنستكمل محاضرتنا طبعا بس بدي أحكي شغلة هلجيت لما أنا مثّلت نتائج الـcontrol اللي حصلت عليها خلال عشرين يوم على الـchart الـLevy Genes Chart هذه النتائج كيف بتعرف إن هذه النتيجة مقبولة أو مرفوضة؟ بيحكيلي نتائج الـcontrol المقبولة لازم تكون", "tokens": [3224, 1863, 14851, 24793, 1211, 3714, 5016, 46958, 43500, 8315, 23032, 3555, 3615, 995, 4724, 3794, 4724, 16254, 5551, 5016, 4117, 1829, 13412, 17082, 37977, 8032, 1211, 7435, 36081, 5296, 15042, 41850, 50113, 11703, 1211, 2655, 8717, 2655, 16373, 7435, 2423, 39184, 40905, 13672, 1829, 11331, 36520, 2655, 25894, 11296, 16490, 1211, 6027, 6225, 46309, 9957, 7251, 20498, 15844, 2423, 39184, 339, 446, 2423, 39184, 11020, 11869, 3632, 279, 49762, 29538, 28239, 2655, 16373, 7435, 9122, 33911, 39894, 3615, 28480, 36145, 29538, 28239, 31371, 7435, 3660, 3714, 4587, 3555, 12610, 3660, 34051, 3714, 28480, 2407, 11242, 3660, 22807, 4724, 1829, 5016, 4117, 1829, 20292, 8717, 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لو لجيت في يوم من الأيام نتيجة outside برة لإتنين standard deviation معناه في عندي مشكلة شو هذه المشكلة؟ error خطأ قد يكون random قد يكون systematic يعني بده حل عشان هيك حطولنا ال Westgard rule اللي هي قواعد Westgard هذه القواعد", "tokens": [9566, 1829, 3555, 45164, 5296, 7435, 36081, 8978, 7251, 20498, 9154, 16247, 1829, 10943, 8717, 31371, 7435, 3660, 2380, 4724, 25720, 5296, 28814, 2655, 1863, 9957, 3832, 25163, 20449, 8315, 3224, 8978, 18871, 16254, 37893, 28820, 3660, 13412, 2407, 29538, 9673, 8592, 28820, 3660, 22807, 6713, 16490, 9566, 10721, 12174, 3215, 7251, 30544, 4974, 12174, 3215, 7251, 30544, 27249, 37495, 22653, 47525, 3224, 11331, 1211, 6225, 8592, 7649, 39896, 4117, 11331, 9566, 12610, 8315, 2423, 4055, 36260, 4978, 13672, 1829, 39896, 12174, 14407, 22488, 4055, 36260, 29538, 25062, 14407, 22488], "avg_logprob": -0.15856799679798084, "compression_ratio": 1.5726872246696035, "no_speech_prob": 0.0, "words": [{"start": 46.72, "end": 47.16, "word": "طيب", "probability": 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This rule warns that a random error أو systematic error may be present in the test system. هذه القاعدة تحذيرية بتقول لك انتبه، ممكن في الأيام الجاية يصير عندك random error أو systematic error.", "tokens": [6780, 307, 33239, 562, 257, 2167, 1969, 14816, 12174, 32640, 3660, 36764, 24401, 3660, 9154, 8717, 2655, 16373, 7435, 2423, 39184, 1969, 307, 2380, 16490, 9640, 7435, 9673, 29245, 3215, 34051, 2423, 39184, 3175, 5296, 28814, 2655, 1863, 9957, 382, 10406, 13, 639, 4978, 12286, 82, 300, 257, 4974, 6713, 34051, 27249, 6713, 815, 312, 1974, 294, 264, 1500, 1185, 13, 29538, 25062, 995, 22488, 3660, 6055, 5016, 8848, 13546, 10632, 39894, 39648, 5296, 4117, 16472, 2655, 3555, 3224, 12399, 3714, 43020, 8978, 16247, 1829, 10943, 25724, 995, 10632, 7251, 9381, 13546, 43242, 4117, 4974, 6713, 34051, 27249, 6713, 13], "avg_logprob": -0.16413984617384353, "compression_ratio": 1.5543478260869565, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 214.95, "end": 215.25, "word": "that", 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بـ2S", "probability": 0.9306640625}], "temperature": 1.0}, {"id": 18, "seek": 44527, "start": 419.17, "end": 445.27, "text": "يعني في يومين متتاليين ظهروا عنده نتجتين من نتائج الـ Control فوق خط الموجة بـ 2 أو ممكن يظهروا تحت خط السالب 2S إذا بنتبق عليهم قاعدة 2 2S هذه القاعدة rejection rule قاعدة رفض يعني لو ظهروا نتجتين outside 2S", "tokens": [40228, 22653, 8978, 7251, 20498, 9957, 44650, 2655, 6027, 1829, 9957, 1357, 116, 3224, 2288, 14407, 43242, 3224, 8717, 2655, 7435, 2655, 9957, 9154, 8717, 2655, 16373, 7435, 2423, 39184, 12912, 6156, 30543, 16490, 9566, 9673, 29245, 3660, 4724, 39184, 568, 34051, 3714, 43020, 7251, 19913, 3224, 2288, 14407, 6055, 33753, 16490, 9566, 21136, 6027, 3555, 568, 50, 11933, 15730, 4724, 29399, 3555, 4587, 25894, 16095, 12174, 995, 22488, 3660, 568, 568, 50, 29538, 25062, 995, 22488, 3660, 26044, 4978, 12174, 995, 22488, 3660, 12602, 5172, 11242, 37495, 22653, 45164, 1357, 116, 3224, 2288, 14407, 8717, 2655, 7435, 2655, 9957, 2380, 568, 50], 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442.55, "word": " يعني", "probability": 0.931396484375}, {"start": 442.55, "end": 442.81, "word": " لو", "probability": 0.97216796875}, {"start": 442.81, "end": 443.21, "word": " ظهروا", "probability": 0.95751953125}, {"start": 443.21, "end": 443.81, "word": " نتجتين", "probability": 0.98603515625}, {"start": 443.81, "end": 444.41, "word": " outside", "probability": 0.7275390625}, {"start": 444.41, "end": 445.27, "word": " 2S", "probability": 0.751220703125}], "temperature": 1.0}, {"id": 19, "seek": 46285, "start": 445.89, "end": 462.85, "text": "في يومين متتاليين معناه في عندي مشكلة وبدي أحلها وعالأغلب بتكون المشكلة systematic error عالأغلب بتكون المشكلة systematic error this rule identifies systematic error only حكينا", "tokens": [41185, 7251, 20498, 9957, 44650, 2655, 6027, 1829, 9957, 20449, 8315, 3224, 8978, 18871, 16254, 37893, 28820, 3660, 46599, 16254, 5551, 5016, 1211, 11296, 4032, 3615, 6027, 10721, 17082, 46152, 39894, 30544, 9673, 8592, 28820, 3660, 27249, 6713, 6225, 6027, 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450.15, "end": 451.47, "word": " وعالأغلب", "probability": 0.8438313802083334}, {"start": 451.47, "end": 452.07, "word": " بتكون", "probability": 0.9306640625}, {"start": 452.07, "end": 452.95, "word": " المشكلة", "probability": 0.99365234375}, {"start": 452.95, "end": 453.53, "word": " systematic", "probability": 0.49609375}, {"start": 453.53, "end": 454.23, "word": " error", "probability": 0.9365234375}, {"start": 454.23, "end": 455.31, "word": " عالأغلب", "probability": 0.89345703125}, {"start": 455.31, "end": 456.01, "word": " بتكون", "probability": 0.934326171875}, {"start": 456.01, "end": 456.79, "word": " المشكلة", "probability": 0.995849609375}, {"start": 456.79, "end": 457.43, "word": " systematic", "probability": 0.806640625}, {"start": 457.43, "end": 458.01, "word": " error", "probability": 0.9521484375}, {"start": 458.01, "end": 458.61, "word": " this", "probability": 0.73388671875}, {"start": 458.61, "end": 459.01, "word": " rule", "probability": 0.91845703125}, {"start": 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"probability": 0.994140625}, {"start": 1244.02, "end": 1244.48, "word": " لليوم", "probability": 0.8772786458333334}, {"start": 1244.48, "end": 1245.12, "word": " العاشر", "probability": 0.9552408854166666}, {"start": 1245.12, "end": 1245.44, "word": " لو", "probability": 0.92626953125}, {"start": 1245.44, "end": 1245.92, "word": " شفتوا", "probability": 0.7919921875}, {"start": 1245.92, "end": 1246.48, "word": " النقاط", "probability": 0.904296875}, {"start": 1246.48, "end": 1246.98, "word": " كلها", "probability": 0.99560546875}, {"start": 1246.98, "end": 1247.6, "word": " طالع", "probability": 0.8626302083333334}, {"start": 1247.6, "end": 1247.94, "word": " فوق", "probability": 0.971435546875}, {"start": 1247.94, "end": 1248.34, "word": " المين", "probability": 0.9296875}, {"start": 1248.34, "end": 1248.76, "word": " مافيش", "probability": 0.5679524739583334}, {"start": 1248.76, "end": 1248.94, "word": " ولا", "probability": 0.8408203125}, {"start": 1248.94, "end": 1249.36, "word": " نقطة", "probability": 0.9895833333333334}, {"start": 1249.36, "end": 1249.8, "word": " تحت", "probability": 0.991455078125}, {"start": 1249.8, "end": 1250.38, "word": " هذه", "probability": 0.61083984375}, {"start": 1250.38, "end": 1251.0, "word": " قاعدة", "probability": 0.9888916015625}, {"start": 1251.0, "end": 1251.54, "word": " اسمها", "probability": 0.9676106770833334}, {"start": 1251.54, "end": 1253.14, "word": " 10XPAR", "probability": 0.5914459228515625}, {"start": 1253.14, "end": 1253.66, "word": " هذه", "probability": 0.96630859375}, {"start": 1253.66, "end": 1254.32, "word": " القاعدة", "probability": 0.9957275390625}, {"start": 1254.32, "end": 1254.62, "word": " إن", "probability": 0.87841796875}, {"start": 1254.62, "end": 1255.16, "word": " وجدت", "probability": 0.7903645833333334}, {"start": 1255.16, "end": 1255.3, "word": " في", "probability": 0.98046875}, {"start": 1255.3, "end": 1255.8, "word": " نتائج", "probability": 0.9931640625}, {"start": 1255.8, "end": 1256.38, "word": " الـcontrol", "probability": 0.666748046875}, {"start": 1256.38, "end": 1257.18, "word": " بحكي", "probability": 0.942138671875}, {"start": 1257.18, "end": 1257.62, "word": " عنها", "probability": 0.9970703125}, {"start": 1257.62, "end": 1258.12, "word": " هي", "probability": 0.8515625}, {"start": 1258.12, "end": 1258.8, "word": " rejected", "probability": 0.464599609375}, {"start": 1258.8, "end": 1259.44, "word": " rule", "probability": 0.92041015625}, {"start": 1259.44, "end": 1260.0, "word": " قاعدة", "probability": 0.9625244140625}, {"start": 1260.0, "end": 1260.72, "word": " مرفوضة", "probability": 0.91630859375}], "temperature": 1.0}, {"id": 57, "seek": 128875, "start": 1261.07, "end": 1288.75, "text": "وإن وجدت بيتنبهني إن في عندي Systematic Error موجود في عندنا أخطاء منهجية موجودة، تمام؟ These rules are violated when there are 10 consecutive quality control results for one level of control are on one side of domain يعني لو أنا اشتغلت هذه الرسمة اللي عندي على control واحد سواء normal أو abnormal، اشتغلت عليه", "tokens": [2407, 28814, 1863, 49610, 3215, 2655, 4724, 36081, 1863, 3555, 3224, 22653, 36145, 8978, 18871, 16254, 8910, 2399, 3300, 2874, 3714, 29245, 23328, 8978, 43242, 8315, 5551, 9778, 9566, 16606, 9154, 3224, 7435, 10632, 3714, 29245, 23328, 3660, 12399, 46811, 10943, 22807, 1981, 4474, 366, 33239, 562, 456, 366, 1266, 30497, 3125, 1969, 3542, 337, 472, 1496, 295, 1969, 366, 322, 472, 1252, 295, 9274, 37495, 22653, 45164, 41850, 1975, 8592, 2655, 17082, 1211, 2655, 29538, 34892, 38251, 3660, 13672, 1829, 18871, 16254, 15844, 1969, 36764, 24401, 8608, 2407, 16606, 2710, 34051, 32847, 12399, 1975, 8592, 2655, 17082, 1211, 2655, 47356], "avg_logprob": -0.18167892828875898, "compression_ratio": 1.5342960288808665, "no_speech_prob": 0.0, "words": [{"start": 1261.07, "end": 1261.41, "word": "وإن", "probability": 0.6238606770833334}, {"start": 1261.41, "end": 1261.99, "word": " وجدت", "probability": 0.9864908854166666}, {"start": 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{"start": 1282.57, "end": 1283.23, "word": " يعني", "probability": 0.87939453125}, {"start": 1283.23, "end": 1283.41, "word": " لو", "probability": 0.86767578125}, {"start": 1283.41, "end": 1283.71, "word": " أنا", "probability": 0.869140625}, {"start": 1283.71, "end": 1284.25, "word": " اشتغلت", "probability": 0.908935546875}, {"start": 1284.25, "end": 1284.49, "word": " هذه", "probability": 0.64013671875}, {"start": 1284.49, "end": 1284.89, "word": " الرسمة", "probability": 0.9581705729166666}, {"start": 1284.89, "end": 1284.99, "word": " اللي", "probability": 0.94921875}, {"start": 1284.99, "end": 1285.25, "word": " عندي", "probability": 0.8369140625}, {"start": 1285.25, "end": 1285.49, "word": " على", "probability": 0.8837890625}, {"start": 1285.49, "end": 1285.97, "word": " control", "probability": 0.744140625}, {"start": 1285.97, "end": 1286.41, "word": " واحد", "probability": 0.985595703125}, {"start": 1286.41, "end": 1286.73, "word": " سواء", "probability": 0.95703125}, {"start": 1286.73, "end": 1287.11, "word": " normal", "probability": 0.53173828125}, {"start": 1287.11, "end": 1287.33, "word": " أو", "probability": 0.92333984375}, {"start": 1287.33, "end": 1288.01, "word": " abnormal،", "probability": 0.748291015625}, {"start": 1288.01, "end": 1288.51, "word": " اشتغلت", "probability": 0.947509765625}, {"start": 1288.51, "end": 1288.75, "word": " عليه", "probability": 0.93505859375}], "temperature": 1.0}, {"id": 58, "seek": 130655, "start": 1289.37, "end": 1306.55, "text": "طلعت عشر نتائج في عشر أيام متتالية كلها فوق المين أو كلها تحت المين تمام النقطة التانية هنحكي فيها على ال slide اللي بعدها هذه القاعدة تفاجنا الـ Systematic Error وRejected Rule تمام", "tokens": [9566, 1211, 34268, 6225, 46309, 8717, 2655, 16373, 7435, 8978, 6225, 46309, 36632, 10943, 44650, 2655, 6027, 10632, 28242, 11296, 6156, 30543, 9673, 9957, 34051, 28242, 11296, 6055, 33753, 9673, 9957, 46811, 10943, 28239, 47432, 3660, 16712, 7649, 10632, 8032, 1863, 5016, 4117, 1829, 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أو النقاط نتائج الـ Control بعيدة عن الـ Mean و بعيدة عن بعضها البعض في dispersion على الرغم من إنها واجعة في الـ Normal Range إذن بدنا نفهم", "tokens": [2304, 4587, 3555, 12610, 3660, 48812, 27842, 2423, 39184, 33778, 4724, 3794, 4032, 9957, 8978, 37893, 28820, 3660, 8978, 6055, 8592, 2655, 2655, 25062, 32640, 33251, 2655, 13546, 34051, 28239, 4587, 41193, 8717, 2655, 16373, 7435, 2423, 39184, 12912, 45030, 25708, 3660, 18871, 2423, 39184, 12302, 4032, 45030, 25708, 3660, 18871, 45030, 11242, 11296, 29739, 3615, 11242, 8978, 24631, 313, 15844, 34892, 17082, 2304, 9154, 36145, 11296, 36764, 7435, 27884, 8978, 2423, 39184, 21277, 33778, 11933, 8848, 1863, 47525, 8315, 8717, 5172, 16095], "avg_logprob": -0.18815103563524427, "compression_ratio": 1.5763546798029557, "no_speech_prob": 8.404254913330078e-06, "words": [{"start": 1814.45, "end": 1815.23, "word": "مقبولة", "probability": 0.94794921875}, {"start": 1815.23, "end": 1815.75, "word": " ضمن", "probability": 0.84423828125}, {"start": 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{"start": 1833.66, "end": 1834.02, "word": " كل", "probability": 0.87744140625}, {"start": 1834.02, "end": 1834.5, "word": " القيم", "probability": 0.857666015625}, {"start": 1834.5, "end": 1835.4, "word": " موجودة", "probability": 0.955078125}, {"start": 1835.4, "end": 1835.78, "word": " ضمن", "probability": 0.96533203125}, {"start": 1835.78, "end": 1836.24, "word": " الـ", "probability": 0.86865234375}, {"start": 1836.24, "end": 1836.52, "word": " Normal", "probability": 0.6640625}, {"start": 1836.52, "end": 1837.06, "word": " Range", "probability": 0.912109375}, {"start": 1837.06, "end": 1837.42, "word": " الـ", "probability": 0.6220703125}, {"start": 1837.42, "end": 1837.62, "word": " X", "probability": 0.65625}, {"start": 1837.62, "end": 1837.88, "word": " bar", "probability": 0.444091796875}, {"start": 1837.88, "end": 1838.3, "word": " موجب", "probability": 0.9417317708333334}, {"start": 1838.3, "end": 1838.58, "word": " أو", "probability": 0.91943359375}, {"start": 1838.58, 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1867.54, "end": 1886.96, "text": "أو هناك زيادة في الـ Random Error في الشغل هذا كله What Cause هذا كله هيؤدي إلى حدوث زيادة في الـ Standard Deviation للقيم لما تيجي تحسبي الـ Standard Deviation بطلع كتير عالي مقدار الانحراف", "tokens": [10721, 2407, 34105, 4117, 30767, 1829, 18513, 3660, 8978, 2423, 39184, 37603, 3300, 2874, 8978, 25124, 17082, 1211, 23758, 28242, 3224, 708, 10865, 23758, 28242, 3224, 39896, 33604, 16254, 30731, 11331, 3215, 2407, 12984, 30767, 1829, 18513, 3660, 8978, 2423, 39184, 21298, 48565, 399, 24976, 4587, 32640, 5296, 15042, 6055, 1829, 7435, 1829, 6055, 5016, 35457, 1829, 2423, 39184, 21298, 48565, 399, 4724, 9566, 1211, 3615, 9122, 2655, 13546, 6225, 6027, 1829, 3714, 28543, 9640, 2423, 7649, 5016, 23557, 5172], "avg_logprob": -0.14978781158541454, "compression_ratio": 1.553191489361702, "no_speech_prob": 4.76837158203125e-07, "words": [{"start": 1867.54, "end": 1868.12, "word": "أو", "probability": 0.960693359375}, {"start": 1868.12, "end": 1868.96, "word": 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هذا", "probability": 0.349609375}, {"start": 1875.1, "end": 1875.64, "word": " كله", "probability": 0.989501953125}, {"start": 1875.64, "end": 1876.62, "word": " هيؤدي", "probability": 0.8370768229166666}, {"start": 1876.62, "end": 1877.12, "word": " إلى", "probability": 0.8828125}, {"start": 1877.12, "end": 1878.2, "word": " حدوث", "probability": 0.9609375}, {"start": 1878.2, "end": 1879.18, "word": " زيادة", "probability": 0.9930419921875}, {"start": 1879.18, "end": 1879.32, "word": " في", "probability": 0.87109375}, {"start": 1879.32, "end": 1879.58, "word": " الـ", "probability": 0.927490234375}, {"start": 1879.58, "end": 1879.9, "word": " Standard", "probability": 0.599609375}, {"start": 1879.9, "end": 1880.58, "word": " Deviation", "probability": 0.902587890625}, {"start": 1880.58, "end": 1881.1, "word": " للقيم", "probability": 0.85205078125}, {"start": 1881.1, "end": 1881.36, "word": " لما", "probability": 0.87548828125}, {"start": 1881.36, "end": 1881.68, "word": " تيجي", "probability": 0.9150390625}, {"start": 1881.68, "end": 1882.24, "word": " تحسبي", "probability": 0.86041259765625}, {"start": 1882.24, "end": 1882.58, "word": " الـ", "probability": 0.904052734375}, {"start": 1882.58, "end": 1882.9, "word": " Standard", "probability": 0.7431640625}, {"start": 1882.9, "end": 1883.58, "word": " Deviation", "probability": 0.970458984375}, {"start": 1883.58, "end": 1884.48, "word": " بطلع", "probability": 0.78033447265625}, {"start": 1884.48, "end": 1885.06, "word": " كتير", "probability": 0.8186848958333334}, {"start": 1885.06, "end": 1885.46, "word": " عالي", "probability": 0.9835611979166666}, {"start": 1885.46, "end": 1886.04, "word": " مقدار", "probability": 0.9723307291666666}, {"start": 1886.04, "end": 1886.96, "word": " الانحراف", "probability": 0.9453125}], "temperature": 1.0}, {"id": 86, "seek": 191411, "start": 1888.13, "end": 1914.11, "text": "طيب لو مقدار التشتت طلع عالي كتير معناه القيم هتبعد عن الـ mean تمام؟ وبالتالي يصير في dispersion تشتت هذه القيم لو انتبهتي على الرسمة من اليوم الأول لليوم التلاتين كل قيمة محصورة بين الـ X bar موجب أو ناقص لـ2S يعني هي قيمة أو قنتين أو تلاتة فوق", "tokens": [9566, 1829, 3555, 45164, 3714, 28543, 9640, 16712, 8592, 2655, 2655, 23032, 1211, 3615, 6225, 6027, 1829, 9122, 2655, 13546, 20449, 8315, 3224, 25062, 32640, 8032, 2655, 3555, 22488, 18871, 2423, 39184, 914, 46811, 10943, 22807, 46599, 6027, 2655, 6027, 1829, 7251, 9381, 13546, 8978, 24631, 313, 6055, 8592, 2655, 2655, 29538, 25062, 32640, 45164, 16472, 2655, 3555, 3224, 31371, 15844, 34892, 38251, 3660, 9154, 45595, 20498, 16247, 12610, 5296, 20292, 20498, 16712, 1211, 9307, 9957, 28242, 12174, 32640, 3660, 3714, 5016, 9381, 13063, 3660, 49374, 2423, 39184, 1783, 2159, 3714, 29245, 3555, 34051, 8717, 995, 4587, 9381, 5296, 39184, 17, 50, 37495, 22653, 39896, 12174, 32640, 3660, 34051, 12174, 29399, 9957, 34051, 6055, 1211, 9307, 3660, 6156, 30543], "avg_logprob": -0.14817708743115265, "compression_ratio": 1.7520661157024793, "no_speech_prob": 0.0, "words": [{"start": 1888.13, "end": 1888.51, "word": "طيب", "probability": 0.9075520833333334}, {"start": 1888.51, "end": 1888.67, "word": " لو", "probability": 0.56396484375}, {"start": 1888.67, "end": 1889.15, "word": " مقدار", "probability": 0.8120930989583334}, {"start": 1889.15, "end": 1889.75, "word": " التشتت", "probability": 0.9010009765625}, {"start": 1889.75, "end": 1890.19, "word": " طلع", "probability": 0.9254557291666666}, {"start": 1890.19, "end": 1890.65, "word": " عالي", "probability": 0.9679361979166666}, {"start": 1890.65, "end": 1890.97, "word": " كتير", "probability": 0.953125}, {"start": 1890.97, "end": 1891.53, "word": " معناه", "probability": 0.8536783854166666}, {"start": 1891.53, "end": 1892.01, "word": " القيم", "probability": 0.91650390625}, {"start": 1892.01, "end": 1892.79, "word": " هتبعد", "probability": 0.89453125}, {"start": 1892.79, "end": 1893.29, "word": " عن", "probability": 0.98681640625}, {"start": 1893.29, "end": 1893.87, "word": " الـ", "probability": 0.924072265625}, {"start": 1893.87, "end": 1894.03, "word": " mean", "probability": 0.1815185546875}, {"start": 1894.03, "end": 1895.41, "word": " تمام؟", "probability": 0.8701171875}, {"start": 1895.41, "end": 1896.05, "word": " وبالتالي", "probability": 0.906640625}, {"start": 1896.05, "end": 1896.41, "word": " يصير", "probability": 0.9153645833333334}, {"start": 1896.41, "end": 1896.57, "word": " في", "probability": 0.9375}, {"start": 1896.57, "end": 1897.47, "word": " dispersion", "probability": 0.6436767578125}, {"start": 1897.47, "end": 1898.15, "word": " تشتت", "probability": 0.9791259765625}, {"start": 1898.15, "end": 1898.65, "word": " هذه", "probability": 0.416015625}, {"start": 1898.65, "end": 1899.09, "word": " القيم", "probability": 0.929443359375}, {"start": 1899.09, "end": 1899.53, "word": " لو", "probability": 0.90234375}, {"start": 1899.53, "end": 1900.21, "word": " انتبهتي", "probability": 0.9552734375}, {"start": 1900.21, "end": 1900.57, "word": " على", "probability": 0.94287109375}, {"start": 1900.57, "end": 1901.43, "word": " الرسمة", "probability": 0.9724934895833334}, {"start": 1901.43, "end": 1901.63, "word": " من", "probability": 0.94384765625}, {"start": 1901.63, "end": 1901.99, "word": " اليوم", "probability": 0.9794921875}, {"start": 1901.99, "end": 1902.47, "word": " الأول", "probability": 0.980224609375}, {"start": 1902.47, "end": 1903.03, "word": " لليوم", "probability": 0.919921875}, {"start": 1903.03, "end": 1903.93, "word": " التلاتين", "probability": 0.9344482421875}, {"start": 1903.93, "end": 1904.65, "word": " كل", "probability": 0.857421875}, {"start": 1904.65, "end": 1905.29, "word": " قيمة", "probability": 0.9728190104166666}, {"start": 1905.29, "end": 1906.47, "word": " محصورة", "probability": 0.98447265625}, {"start": 1906.47, "end": 1907.03, "word": " بين", "probability": 0.974609375}, {"start": 1907.03, "end": 1908.03, "word": " الـ", "probability": 0.747802734375}, {"start": 1908.03, "end": 1908.31, "word": " X", "probability": 0.484130859375}, {"start": 1908.31, "end": 1908.69, "word": " bar", "probability": 0.49169921875}, {"start": 1908.69, "end": 1909.33, "word": " موجب", "probability": 0.8377278645833334}, {"start": 1909.33, "end": 1909.59, "word": " أو", "probability": 0.91650390625}, {"start": 1909.59, "end": 1910.07, "word": " ناقص", "probability": 0.9888916015625}, {"start": 1910.07, "end": 1911.19, "word": " لـ2S", "probability": 0.74591064453125}, {"start": 1911.19, "end": 1911.99, "word": " يعني", "probability": 0.93310546875}, {"start": 1911.99, "end": 1912.21, "word": " هي", "probability": 0.88427734375}, {"start": 1912.21, "end": 1912.59, "word": " قيمة", "probability": 0.9895833333333334}, {"start": 1912.59, "end": 1912.75, "word": " أو", "probability": 0.6923828125}, {"start": 1912.75, "end": 1913.13, "word": " قنتين", "probability": 0.7197265625}, {"start": 1913.13, "end": 1913.29, "word": " أو", "probability": 0.916015625}, {"start": 1913.29, "end": 1913.75, "word": " تلاتة", "probability": 0.98046875}, {"start": 1913.75, "end": 1914.11, "word": " فوق", "probability": 0.6934814453125}], "temperature": 1.0}, {"id": 87, "seek": 192483, "start": 1914.65, "end": 1924.83, "text": "لكن لو كنظرة أولى هتحس القيم فيها dispersion فيها تشطط و بعيدة عن المين تمام؟ يعطيكوا العافية", "tokens": [1211, 19452, 45164, 9122, 1863, 19913, 25720, 5551, 12610, 7578, 8032, 2655, 5016, 3794, 25062, 32640, 8978, 11296, 24631, 313, 8978, 11296, 6055, 8592, 9566, 9566, 4032, 45030, 25708, 3660, 18871, 9673, 9957, 46811, 10943, 22807, 37495, 9566, 1829, 4117, 14407, 18863, 31845, 10632], "avg_logprob": -0.1596354219648573, "compression_ratio": 1.28, "no_speech_prob": 0.0, "words": [{"start": 1914.65, "end": 1915.09, "word": "لكن", "probability": 0.89013671875}, {"start": 1915.09, "end": 1915.29, "word": " لو", "probability": 0.9716796875}, {"start": 1915.29, "end": 1916.11, "word": " كنظرة", "probability": 0.893310546875}, {"start": 1916.11, "end": 1916.55, "word": " أولى", "probability": 0.9620768229166666}, {"start": 1916.55, "end": 1917.23, "word": " هتحس", "probability": 0.8453369140625}, {"start": 1917.23, "end": 1917.81, "word": " القيم", "probability": 0.90869140625}, {"start": 1917.81, "end": 1918.67, "word": " فيها", "probability": 0.948974609375}, {"start": 1918.67, "end": 1919.63, "word": " dispersion", "probability": 0.8779296875}, {"start": 1919.63, "end": 1920.19, "word": " فيها", "probability": 0.901123046875}, {"start": 1920.19, "end": 1920.81, "word": " تشطط", "probability": 0.8824462890625}, {"start": 1920.81, "end": 1921.13, "word": " و", "probability": 0.6904296875}, {"start": 1921.13, "end": 1921.75, "word": " بعيدة", "probability": 0.9459635416666666}, {"start": 1921.75, "end": 1922.27, "word": " عن", "probability": 0.98095703125}, {"start": 1922.27, "end": 1922.97, "word": " المين", "probability": 0.659912109375}, {"start": 1922.97, "end": 1923.85, "word": " تمام؟", "probability": 0.7198893229166666}, {"start": 1923.85, "end": 1924.35, "word": " يعطيكوا", "probability": 0.78349609375}, {"start": 1924.35, "end": 1924.83, "word": " العافية", "probability": 0.9749348958333334}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 1931.7145, "duration_after_vad": 1901.4787499999984}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/AJ9OpH9yA0U_raw.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/AJ9OpH9yA0U_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..6fc8faa6243976bf246eed541607529f77306036
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/AJ9OpH9yA0U_raw.srt
@@ -0,0 +1,1460 @@
+1
+00:00:01,100 --> 00:00:05,940
+هنستكمل محاضرتنا طبعا بس بدي أحكي شغلة هلجيت لما
+
+2
+00:00:05,940 --> 00:00:10,700
+أنا مثّلت نتائج الـcontrol اللي حصلت عليها خلال
+
+3
+00:00:10,700 --> 00:00:16,100
+عشرين يوم على الـchart الـLevy Genes Chart هذه
+
+4
+00:00:16,100 --> 00:00:21,440
+النتائج كيف بتعرف إن هذه النتيجة مقبولة أو مرفوضة؟
+
+5
+00:00:21,440 --> 00:00:27,990
+بيحكيلي نتائج الـcontrol المقبولة لازم تكونموجودة
+
+6
+00:00:27,990 --> 00:00:34,510
+ضمن X bar موجب أو ناقص 2 standard deviation لو
+
+7
+00:00:34,510 --> 00:00:39,750
+النقاط اللي شفناها على المنحنة كانت محصورة بين الـ
+
+8
+00:00:39,750 --> 00:00:44,310
+X bar الـ mean موجب أو ناقص 2 standard deviation
+
+9
+00:00:44,310 --> 00:00:49,240
+إذن النتائج مقبولةطيب لو لجيت في يوم من الأيام
+
+10
+00:00:49,240 --> 00:00:55,360
+نتيجة outside برة لإتنين standard deviation معناه
+
+11
+00:00:55,360 --> 00:01:00,340
+في عندي مشكلة شو هذه المشكلة؟ error خطأ قد يكون
+
+12
+00:01:00,340 --> 00:01:05,360
+random قد يكون systematic يعني بده حل عشان هيك
+
+13
+00:01:05,360 --> 00:01:10,800
+حطولنا ال Westgard rule اللي هي قواعد Westgard هذه
+
+14
+00:01:10,800 --> 00:01:18,570
+القواعدإذن بتسهّن علينا اكتشاف وين الخطأ في أي يوم
+
+15
+00:01:18,570 --> 00:01:24,050
+حدث خطأ وإيش هو الخطأ اللي صار لما شغلنا الـ
+
+16
+00:01:24,050 --> 00:01:28,710
+Control أول قاعدة، خلّينا نستعرض مع بعض القواعد
+
+17
+00:01:28,710 --> 00:01:34,110
+أول قاعدة اسمها 1.2S تفاجنة S يقصد فيها
+
+18
+00:01:34,110 --> 00:01:40,290
+الـStandard Deviationلو جينا نطبق قاعدة الـ N تمام
+
+19
+00:01:40,290 --> 00:01:45,310
+الـ N قلنا الـ number عدد نتائج الـ control اللي
+
+20
+00:01:45,310 --> 00:01:50,810
+فيها المشكلة هنا كتبلك واحد معناه عدد نتائج الـ
+
+21
+00:01:50,810 --> 00:01:55,410
+control اللي فيها المشكلة نتيجة واحدة اتنين F
+
+22
+00:01:55,410 --> 00:02:01,310
+معناه هذه النتيجة الواحدة outside طلعت برا لإتنين
+
+23
+00:02:01,310 --> 00:02:08,150
+standard deviationإذن لو في يوم من الأيام طلعت أن
+
+24
+00:02:08,150 --> 00:02:12,670
+هذا نص القاعدة 1,2,S في يوم من الأيام لو طلعت
+
+25
+00:02:12,670 --> 00:02:18,410
+نتيجة واحدة outside من نتائج الـcontrol برا لإتنين
+
+26
+00:02:18,410 --> 00:02:24,010
+standard deviation برا، outside، وين برا؟ تعالوا
+
+27
+00:02:24,010 --> 00:02:29,590
+على الرسمة نشوفاتطلعولي في اليوم التاني لو جيتي
+
+28
+00:02:29,590 --> 00:02:35,010
+على اليوم التاني هتلاقي نتيجة الـ Control طلعت برا
+
+29
+00:02:35,010 --> 00:02:41,570
+الموجة بـ 2SD شايفين الموجة بـ 2SD والخط الأصفر
+
+30
+00:02:41,570 --> 00:02:47,600
+فيه فوجه نقطةيعني هي في يوم من الأيام طلعت نتيجة
+
+31
+00:02:47,600 --> 00:02:54,880
+فوق الـ2S دي أو ممكن تطلع تحت السالب 2S دي لو
+
+32
+00:02:54,880 --> 00:02:59,960
+نزلنا تحت، تحت المين، عندي سالب 2S دي أو هذا الخط
+
+33
+00:02:59,960 --> 00:03:07,160
+الأصفر لو النقطة طلعت برضه تحته سواء فوق الموجة 2S
+
+34
+00:03:07,160 --> 00:03:12,780
+أو تحت السالب 2S ما هي outside 2Sأنا لما أحكيكوا
+
+35
+00:03:12,780 --> 00:03:17,880
+outside برا الإتنين S أقصد إما فوق الموجة بإتنين
+
+36
+00:03:17,880 --> 00:03:23,440
+تطلع النقطة أو تحت السالب إتنين تمام؟ بيحكيلي هذه
+
+37
+00:03:23,440 --> 00:03:26,860
+القاعدة a warning rule قاعدة تحذيرية يعني لو
+
+38
+00:03:26,860 --> 00:03:30,720
+طلعتلك نتيجة من نتائج ال control تنطبق عليها هذه
+
+39
+00:03:30,720 --> 00:03:36,350
+القاعدة هذه قاعدة تحذيرية بتحذركthat is violated
+
+40
+00:03:36,350 --> 00:03:40,350
+when a single control observation قيمة واحدة من
+
+41
+00:03:40,350 --> 00:03:45,390
+نتائج الـ control is outside خارج الموجد أو الـ
+
+42
+00:03:45,390 --> 00:03:50,770
+minus لإتنين as limits. This rule warns that a
+
+43
+00:03:50,770 --> 00:03:53,890
+random error أو systematic error may be present in
+
+44
+00:03:53,890 --> 00:03:56,730
+the test system. هذه القاعدة تحذيرية بتقول لك
+
+45
+00:03:56,730 --> 00:04:02,570
+انتبه، ممكن في الأيام الجاية يصير عندك random
+
+46
+00:04:02,570 --> 00:04:06,760
+error أو systematic error.إذا لو ظهرت عندي هذه
+
+47
+00:04:06,760 --> 00:04:11,600
+القاعدة في نتائج الـ Control إنه خد حذرك لكن هذه
+
+48
+00:04:11,600 --> 00:04:15,460
+القاعدة لا تعتبر rejection rule قاعدة يعني .. يعني
+
+49
+00:04:15,460 --> 00:04:18,500
+إيش يعني rejection؟ رفض إنه أنا لو طلعت هذه
+
+50
+00:04:18,500 --> 00:04:22,200
+النتيجة معي أو قيمة من القيم برا الإتنين أسمها،
+
+51
+00:04:22,200 --> 00:04:28,400
+برفضها عادي بقبلها، لكن بدي أخد الحيطة و الحذر و
+
+52
+00:04:28,400 --> 00:04:36,460
+أنتبه في الخطوات الجايةالقاعدة التانية 1 3 F يعني
+
+53
+00:04:36,460 --> 00:04:40,960
+في يوم من الأيام ظهرت نتيجة واحدة من نتائج
+
+54
+00:04:40,960 --> 00:04:45,860
+الـcontrol outside برا التلاتة standard deviation
+
+55
+00:04:45,860 --> 00:04:51,860
+إما فوق الموجة، إما فوق خط الموجة بتلاتة F ديأو
+
+56
+00:04:51,860 --> 00:04:57,100
+تحت خط السالب تلاتة S دي تعالوا نشوف على الرسمة في
+
+57
+00:04:57,100 --> 00:05:01,820
+اليوم السادس زهرت النقطة لو طلعنا فوق وشوفنا
+
+58
+00:05:01,820 --> 00:05:07,960
+النتيجة زهرت فوق الموجة بتلاتة S أو لو زهرت تحت خط
+
+59
+00:05:07,960 --> 00:05:14,080
+السالب تلاتة S برضه صح المهم المهم برا التلاتة S
+
+60
+00:05:14,970 --> 00:05:21,170
+إذاً هذه النتيجة وهذه القاعدة اسمها قاعدة 1.3S one
+
+61
+00:05:21,170 --> 00:05:25,610
+equality control result outside موجب أو ناقص
+
+62
+00:05:25,610 --> 00:05:29,530
+التلاتة standard deviation وهذه القاعدة تعتبر
+
+63
+00:05:29,530 --> 00:05:33,590
+rejection rule قاعدة رفض يعني لو ظهرت نتيجة من
+
+64
+00:05:33,590 --> 00:05:37,930
+نتائج ال control برة التلاتة S دي برفضها وبوجه
+
+65
+00:05:37,930 --> 00:05:42,710
+الشغل ولازم أشوف وين المشكلة اللي جعلت هذه القيمة
+
+66
+00:05:42,710 --> 00:05:49,450
+خاطئةوجود هذه القاعدة ينذر بوجود إما Unacceptable
+
+67
+00:05:49,450 --> 00:05:54,110
+Random Error خطأ عشوائي غير مقبول أو بداية لـ
+
+68
+00:05:54,110 --> 00:05:59,370
+Systematic Error بس الأرجح إنه لو ظهرت قاعدة الـ 1
+
+69
+00:05:59,370 --> 00:06:03,710
+تلاتة أسف نتائج الـ Control إذا فاندي Random Error
+
+70
+00:06:03,710 --> 00:06:05,690
+الأرجح Random Error
+
+71
+00:06:08,460 --> 00:06:14,380
+نيجي للقاعدة التالتة القاعدة التالتة هي 2 2 S يعني
+
+72
+00:06:14,380 --> 00:06:21,460
+في يومين متتاليان ظهرت عندي نتجتين من نتائج الـ
+
+73
+00:06:21,460 --> 00:06:28,180
+Control هدول النتجتين ظهروا outside الـ 2S إما فوق
+
+74
+00:06:28,180 --> 00:06:35,790
+الموجب 2 أو تحت خط السالب 2بنفس الاتجاه تعالى نشوف
+
+75
+00:06:35,790 --> 00:06:40,890
+الرسمة و بعدين نقرأ ال slide هي لو جينا على الرسمة
+
+76
+00:06:40,890 --> 00:06:44,750
+في اليوم التاني و اليوم التالت هنشوف في اليوم
+
+77
+00:06:44,750 --> 00:06:51,150
+التاني ظهرت النقطة الصفراء فوق خط الموجة بـ2S وفي
+
+78
+00:06:51,150 --> 00:06:54,870
+اليوم التالت ظهرت نقطة صفراء نتيجة من نتائج
+
+79
+00:06:54,870 --> 00:07:00,730
+الـcontrol برضه فوق الموجة بـ2Sيعني في يومين
+
+80
+00:07:00,730 --> 00:07:06,670
+متتاليين ظهروا عنده نتجتين من نتائج الـ Control
+
+81
+00:07:06,670 --> 00:07:13,310
+فوق خط الموجة بـ 2 أو ممكن يظهروا تحت خط السالب 2S
+
+82
+00:07:13,310 --> 00:07:19,990
+إذا بنتبق عليهم قاعدة 2 2S هذه القاعدة rejection
+
+83
+00:07:19,990 --> 00:07:26,090
+rule قاعدة رفض يعني لو ظهروا نتجتين outside 2Sفي
+
+84
+00:07:26,090 --> 00:07:30,150
+يومين متتاليين معناه في عندي مشكلة وبدي أحلها
+
+85
+00:07:30,150 --> 00:07:35,310
+وعالأغلب بتكون المشكلة systematic error عالأغلب
+
+86
+00:07:35,310 --> 00:07:39,010
+بتكون المشكلة systematic error this rule
+
+87
+00:07:39,010 --> 00:07:44,330
+identifies systematic error only حكيناthe criteria
+
+88
+00:07:44,330 --> 00:07:48,730
+for this rule ايش نص القاعدة؟ two consecutive
+
+89
+00:07:48,730 --> 00:07:53,550
+equality control results يعني نتجتين من نتائج ال
+
+90
+00:07:53,550 --> 00:07:58,870
+control في يومين متتالين كلمة consecutive متتالين
+
+91
+00:07:59,990 --> 00:08:05,430
+طلع greater than outside يعني الأتنين S on the
+
+92
+00:08:05,430 --> 00:08:09,770
+same side of the mean تمام؟ إن النتجتين مع بعض
+
+93
+00:08:09,770 --> 00:08:14,750
+التنتين بتطلع فوق الأتنين F أو تحت خط الثالب أتنين
+
+94
+00:08:14,750 --> 00:08:20,610
+Fأما بجية الجملة على الـ slide التانية هنشرحها or
+
+95
+00:08:20,610 --> 00:08:25,130
+both controls in the same run exceeds موجب أو ناقص
+
+96
+00:08:25,130 --> 00:08:30,690
+2 SD على ال slide التانية patient results cannot
+
+97
+00:08:30,690 --> 00:08:34,580
+be reported لما بظهروا عندى نتائج ال controlتنتين
+
+98
+00:08:34,580 --> 00:08:39,500
+برا الأتنين S ممنوع أحط عينات المرضى في الجهاز
+
+99
+00:08:39,500 --> 00:08:44,300
+وأشتغلهم لازم أحل مشكلة ال control بعدين نشبك
+
+100
+00:08:44,300 --> 00:08:48,820
+عينات المرضى وهذا الاشي بحتاج لـ Corrective Action
+
+101
+00:08:48,820 --> 00:08:52,620
+أكيد بحتاج أني أنا حكيتلكوا عندي Systematic Error
+
+102
+00:08:52,620 --> 00:08:58,080
+يعني لازم أشوف حل لمشكلة الـ Systematic Error ونحل
+
+103
+00:08:58,080 --> 00:09:04,820
+الخطأخلونا نحكي عن الرسمة نشوف الرسمة اللي تحت
+
+104
+00:09:04,820 --> 00:09:09,880
+بعدين نطلع على الرسمة اللي فوق الرسمة اللي تحت لو
+
+105
+00:09:09,880 --> 00:09:15,860
+جيته على اليوم الرابع هتلاقي النقطة الخضرة فوق خط
+
+106
+00:09:15,860 --> 00:09:22,520
+الموجة بـ2Sوبرضه في اليوم الخامس برضه كمان نقطة
+
+107
+00:09:22,520 --> 00:09:28,540
+خضرة فوق الخط الموجة بـ 2S إذا في يومين متتاليين
+
+108
+00:09:28,540 --> 00:09:33,960
+ظهروا عندى نتجتين فوق الموجة بـ 2S إذا هذه قاعدة
+
+109
+00:09:33,960 --> 00:09:40,810
+الـ 22S لو انتبهتيتحت كتبلك Level 1 ولون أخضر
+
+110
+00:09:40,810 --> 00:09:45,770
+Level 1 يقصد فيه الـ Normal Control يقصد فيه أنه
+
+111
+00:09:45,770 --> 00:09:51,350
+أنا بس مشيت Normal Control بيحكيلي لو أنتي مشيتي
+
+112
+00:09:51,350 --> 00:09:55,070
+الـ Two Control يعني الـ Normal Control و الـ
+
+113
+00:09:55,070 --> 00:10:00,510
+Abnormal Control Level 1 و Level 2 انشوف الرسمة
+
+114
+00:10:00,510 --> 00:10:03,410
+اللي فوق إذا الرسمة اللي تحت هذه كلنا عارفينها
+
+115
+00:10:03,410 --> 00:10:08,410
+والقاعدة عاديةإذا مشيت أنا control واحد هيك الكلام
+
+116
+00:10:08,410 --> 00:10:12,750
+صحيح طيب لو أنا مشيت to control level واحد و level
+
+117
+00:10:12,750 --> 00:10:17,270
+اتنين انشوف الرسمة اللي فوق الرسمة اللي فوق بتقول
+
+118
+00:10:17,270 --> 00:10:22,770
+لي في يوم واحد أنا مشيت controlينnormal control و
+
+119
+00:10:22,770 --> 00:10:27,910
+abnormal control يعني هيطلعوا عندى نتجتين لو طلعوا
+
+120
+00:10:27,910 --> 00:10:34,310
+النتجتين outside الـ 2S سواء أعلى من موجب الـ 2 أو
+
+121
+00:10:34,310 --> 00:10:39,810
+تحت خط السالب 2 إذا أيضا تنطبق عليها قاعدة الـ 2
+
+122
+00:10:39,810 --> 00:10:45,090
+2S هي في اليوم التالتمشيت Normal و Abnormal
+
+123
+00:10:45,090 --> 00:10:50,850
+Control والنتشتين مع بعض طلعوا تحت خط السالب 2 زي
+
+124
+00:10:50,850 --> 00:10:56,150
+ما انتوا شايفين أو اذا طلعوا فوق خط موجب 2، فوق خط
+
+125
+00:10:56,150 --> 00:11:00,970
+الموجب 2، برضه صح، اذا يا اما بتقولي في يومين
+
+126
+00:11:00,970 --> 00:11:07,800
+متتالين ظهرت نتشتين أو اما الواحد يقول انهفي يوم
+
+127
+00:11:07,800 --> 00:11:11,880
+واحد أنا اشتغلت Controllain يعني في اليوم الواحد
+
+128
+00:11:11,880 --> 00:11:19,380
+ظهرت عندى نتج تان تمام القاعدة الرابعة اسمها الـ
+
+129
+00:11:19,380 --> 00:11:26,120
+R4S تعالى نشوف ايش هذه القاعدة على شو بتنص القاعدة
+
+130
+00:11:26,120 --> 00:11:32,520
+R4S بحكيلي انه تعالى نشوفها على الرسمة و بعدين
+
+131
+00:11:32,520 --> 00:11:38,260
+نرجع نشوف على ايش بتنص من الرسمة هنفهملو جيت على
+
+132
+00:11:38,260 --> 00:11:43,260
+اليوم الخامس والسادس معي على الرسم اللي على اليمين
+
+133
+00:11:43,260 --> 00:11:49,160
+لو جينا على اليوم الخامس هتلاحظي طلعت نقطة صفراء
+
+134
+00:11:49,160 --> 00:11:55,210
+نتيجة الـ Control تحت خط السالب 2S تمامفي اليوم
+
+135
+00:11:55,210 --> 00:12:00,270
+السادس لو جيت هلاقي طلعت نتيجة الـ Control النقطة
+
+136
+00:12:00,270 --> 00:12:07,670
+الصفراء فوق خط الموجب 2S يعني بقدر أستنتج القاعدة
+
+137
+00:12:07,670 --> 00:12:15,420
+تاعة الـ R4S في يومين متتالينطلع عندى نتجتين لـ
+
+138
+00:12:15,420 --> 00:12:20,920
+Control نتيجة من النتائج طلعت تحت السالي بـ 2S
+
+139
+00:12:20,920 --> 00:12:26,980
+ونتيجة الـ نتيجة الأخرى طلعت فوق خط الموجة بـ 2S
+
+140
+00:12:26,980 --> 00:12:32,780
+يعني واحدة فوق وواحدة تحت عكس الـ 2 2S الـ 2 2S
+
+141
+00:12:32,780 --> 00:12:38,940
+تنتل يا إما معبعة فوق يا إما معبعة تحت لكن الـ R4S
+
+142
+00:12:38,940 --> 00:12:45,390
+نتيجةتحت السلب 2 ونتيجة فوق الموجب 2 هذا نص
+
+143
+00:12:45,390 --> 00:12:50,650
+القاعدة القاعدة يا جماعة rejection rule يعني لو
+
+144
+00:12:50,650 --> 00:12:54,470
+ظهرت هذه القاعدة عندى في نتائج ال control برفض
+
+145
+00:12:54,470 --> 00:12:59,910
+نتيجة ال control معناه بينزر لوجود random error
+
+146
+00:12:59,910 --> 00:13:05,650
+خطأ عشوائي وبدنا انحله تمام وجود قاعدة ال R4S
+
+147
+00:13:05,650 --> 00:13:10,420
+معناه عندنا خطأ عشوائي وبدنا انحلهتعالى نشوف
+
+148
+00:13:10,420 --> 00:13:16,560
+الرسمة اللي على اليسار بدنا نقرأ تحت level 1 يعني
+
+149
+00:13:16,560 --> 00:13:21,400
+normal control level 2 يعني abnormal control يعني
+
+150
+00:13:21,400 --> 00:13:27,160
+في اليوم الواحد في اليوم التالت مشة controlين مشة
+
+151
+00:13:27,160 --> 00:13:31,960
+ال normal وال abnormal نتيجة من النتائج نتيجة
+
+152
+00:13:31,960 --> 00:13:37,040
+اللون الأخضر ال normal control طلعت فوق الموجب 2S
+
+153
+00:13:37,460 --> 00:13:42,460
+ونتيجة الـ Level 2 الـ Abnormal Control طلعت تحت
+
+154
+00:13:42,460 --> 00:13:48,900
+السالب 2S برضه تنطبق عليها قاعدة الـ R4S في يوم
+
+155
+00:13:48,900 --> 00:13:54,620
+واحد مشيت Control 2 أو في يومينوتتاليين في كل يوم
+
+156
+00:13:54,620 --> 00:13:58,820
+نتيجة طلعت واحدة طلعت تحت السلب اتنين واحدة طلعت
+
+157
+00:13:58,820 --> 00:14:05,600
+موجب اتنين طيب لو ارجعنا للقاعدة R4S الاربعة
+
+158
+00:14:05,600 --> 00:14:12,510
+standard deviation من وين جايين؟ جايين منالفرق بين
+
+159
+00:14:12,510 --> 00:14:17,550
+النقطتين النقطة اللي فوق والنقطة اللي تحت نرجع
+
+160
+00:14:17,550 --> 00:14:24,010
+برضه على الرسم اللي على اليمين النقطة اللي فوق هي
+
+161
+00:14:24,010 --> 00:14:28,550
+موجب اتنين صح ولا لأ انهاطالع فوق الموجة بتنين
+
+162
+00:14:28,550 --> 00:14:33,150
+والنقطة اللي تحت طالعة تحت السالي بتنين لو حكيتلك
+
+163
+00:14:33,150 --> 00:14:37,610
+هتيل الفرق بين النقطين يعني طرح يعني هتطرح النقطة
+
+164
+00:14:37,610 --> 00:14:42,230
+اللي فوق من النقطة اللي تحت يعني هتحكي موجة بتنين
+
+165
+00:14:42,230 --> 00:14:50,730
+ناقص بدي أطرحبنحكي شو موجة بتنين ناقص سالب اتنين و
+
+166
+00:14:50,730 --> 00:14:56,170
+هي ساوي أربعة كيف النقطة اللي فوق موجة بتنين بدي
+
+167
+00:14:56,170 --> 00:15:00,630
+أطرحها من النقطة اللي تحت يعني موجة بتنين ناقص
+
+168
+00:15:00,630 --> 00:15:06,650
+سالب اتنين فبطلع الفرق بين النقطتين أربعة standard
+
+169
+00:15:06,650 --> 00:15:12,290
+deviationنقرأ الكلام، this rule identifies random
+
+170
+00:15:12,290 --> 00:15:16,150
+error only حكينا وجودها معناه random error one
+
+171
+00:15:16,150 --> 00:15:21,870
+control exceeds the mean by minus 2SD نتيجة واحدة
+
+172
+00:15:21,870 --> 00:15:26,030
+طلعت تحت السالب 2 and the other control exceeds
+
+173
+00:15:26,030 --> 00:15:32,320
+the mean by plus 2SD واحدة فوق الـ2SDالـ
+
+174
+00:15:32,320 --> 00:15:35,260
+difference between the two results will therefore
+
+175
+00:15:35,260 --> 00:15:39,880
+exceed 4SD الفرق بين النقطين أربعة standard
+
+176
+00:15:39,880 --> 00:15:46,610
+deviation هذا المطلوب من هذه الـ slideالقاعدة
+
+177
+00:15:46,610 --> 00:15:53,650
+الخامسة أربعة واحد S بفهم إنه في أربع أيام متتالية
+
+178
+00:15:53,650 --> 00:15:59,450
+ظهرت عندي أربع نتائج من نتائج الـ Control كلهم
+
+179
+00:15:59,450 --> 00:16:05,210
+outside الواحد standard deviation كلهم إما أعلى من
+
+180
+00:16:05,210 --> 00:16:11,250
+موجة بواحد أو كلهم تحت خط السالب واحد SD تعالوا
+
+181
+00:16:11,250 --> 00:16:16,050
+نشوف الرسمةفي اليوم، ركزوا معي السابع والتاني
+
+182
+00:16:16,050 --> 00:16:20,870
+والتاسع والعاشر، تمام؟ في اليوم السابع، النتيجة
+
+183
+00:16:20,870 --> 00:16:26,010
+طلعت هي المين وهي سالب واحد أس اللون الأخضر، الخط
+
+184
+00:16:26,010 --> 00:16:31,070
+اللي لونه أخضر في اليوم السابع، النتيجة طلعت تحت
+
+185
+00:16:31,070 --> 00:16:34,510
+السالب واحد، هي اللون الأخضر وهي النقطة الخضرة تحت
+
+186
+00:16:34,510 --> 00:16:38,910
+السالب واحد وفي اليوم التامن، أيضًا النتيجة تحت
+
+187
+00:16:38,910 --> 00:16:43,010
+السالب واحد، okay هي على الخط، بس هي تحتفي اليوم
+
+188
+00:16:43,010 --> 00:16:47,170
+التاسع أيضًا النتيجة تحت السالب واحد وفي اليوم
+
+189
+00:16:47,170 --> 00:16:51,990
+العاشر برضه النتيجة تحت السالب واحد أو ممكن الأربع
+
+190
+00:16:51,990 --> 00:16:57,130
+نقاط هدول كلهم يطلعوا فوق خط الموجة بواحد أس هي
+
+191
+00:16:57,130 --> 00:17:01,740
+موجة بواحد أس بيطلعوا فوقهيا تحت السالب واحد يا
+
+192
+00:17:01,740 --> 00:17:07,220
+فوق الموجب واحد هذه بحكي عنها قاعدة 41S هذه
+
+193
+00:17:07,220 --> 00:17:11,540
+القاعدة rejection rule وجودها مرفوض ولو ان وجدت
+
+194
+00:17:11,540 --> 00:17:16,680
+إذا تنذر له وجود systematic error يجب حله سريعا،
+
+195
+00:17:16,680 --> 00:17:21,430
+تمام؟نقرأ The criteria which must be met to
+
+196
+00:17:21,430 --> 00:17:25,770
+manifest this rule are بتنص على four consecutive
+
+197
+00:17:25,770 --> 00:17:29,550
+equality control result for one level of control
+
+198
+00:17:29,550 --> 00:17:34,950
+are outside الموجب أو ناقص الواحد SD on the same
+
+199
+00:17:34,950 --> 00:17:39,740
+side of the mean أربع نتائج في أيام متتاليةطلعوا
+
+200
+00:17:39,740 --> 00:17:45,040
+خارج الـ 1S إما فوق الموجة بـ 1 أو تحت السالب 1
+
+201
+00:17:45,040 --> 00:17:49,440
+إذا نشيت نوع واحد من الـ Control هذه الرسمة لما
+
+202
+00:17:49,440 --> 00:17:53,660
+بمشي يا Normal Control يا Abnormal Control أما
+
+203
+00:17:53,660 --> 00:17:58,420
+النقطة الأخرى، على الـ slide التانية هنشرحها قلنا
+
+204
+00:17:58,420 --> 00:18:03,380
+هذه القاعدة تكشف الـ Systematic Error وهي قاعدة
+
+205
+00:18:03,380 --> 00:18:09,280
+Rejected Rule مرفوضةنيجي على هذه الـ slide تعالوا
+
+206
+00:18:09,280 --> 00:18:13,460
+معي الرسم اللي فوق امشي فقط level واحد يعني
+
+207
+00:18:13,460 --> 00:18:18,540
+control واحد يعني انتبهوا اليوم التالت والرابع
+
+208
+00:18:18,540 --> 00:18:24,610
+والخامس والسادس هذه أربع أيام متتاليةتمام اليوم
+
+209
+00:18:24,610 --> 00:18:30,230
+التالت والرابع والخامس والسادس كل النتائج طلعت تحت
+
+210
+00:18:30,230 --> 00:18:37,530
+خط السالب واحد S إذا هذه قاعدة أربعة واحد S لكن لو
+
+211
+00:18:37,530 --> 00:18:43,300
+اشتغلت Normal و Abnormal Control في نفس اليومlevel
+
+212
+00:18:43,300 --> 00:18:48,420
+واحد و level اتنين يعني هتحكي في اليوم التاني
+
+213
+00:18:48,420 --> 00:18:52,600
+انتبهوا على الرسم اللي تحت في اليوم التاني اشتغل
+
+214
+00:18:52,600 --> 00:18:57,860
+controlين normal و abnormal control اللون الأخضر و
+
+215
+00:18:57,860 --> 00:19:04,920
+ال move اللي فوق بعد تمام؟هدولا النقطتين طلعوا فوق
+
+216
+00:19:04,920 --> 00:19:11,000
+الموجة بـ 1S تمام، يعني برا الـ 1S، okay في اليوم
+
+217
+00:19:11,000 --> 00:19:15,480
+التالت برضه اشتغل Normal و Abnormal Control و
+
+218
+00:19:15,480 --> 00:19:21,140
+النتيجتين برضه الأخضر والموف طلعوا برضه فوق الموجة
+
+219
+00:19:21,140 --> 00:19:25,980
+بـ 1S إذا لما بدك تشتغلي Controlling في نفس اليوم
+
+220
+00:19:26,210 --> 00:19:31,090
+بتسيري تحكي في يومين متتاليين طلعوا عندي أربع
+
+221
+00:19:31,090 --> 00:19:39,070
+نتائج فوق الـ1S، تمام؟ سواء فوق الموجب 1 أو الأربع
+
+222
+00:19:39,070 --> 00:19:45,190
+نقاط هذه طلعت تحت السلب 1 إذا لو مشيت Ctrl 1، بحكي
+
+223
+00:19:45,190 --> 00:19:49,270
+في أربع أيام متتالية، طلعوا عندي أربع نتائجطيب لو
+
+224
+00:19:49,270 --> 00:19:54,570
+في اليوم الواحد مشيت نتج تان هقول في يومين متتالين
+
+225
+00:19:54,570 --> 00:19:59,110
+طلع عندي أربع نتاج لأنه فعليا في اليوم الواحد
+
+226
+00:19:59,110 --> 00:20:06,990
+اشتغل Controlling وبالتالي طلّع نتج تانعشرة X bar
+
+227
+00:20:06,990 --> 00:20:13,310
+عشرة X bar يعني في عشر أيام متتالية ظهرت عندي عشر
+
+228
+00:20:13,310 --> 00:20:19,870
+نتائج هذه العشر نتائج إما ظهرت كلها فوق خط المين
+
+229
+00:20:19,870 --> 00:20:24,710
+أو تحت خط المين المين هو الـ X bar هو الوسط
+
+230
+00:20:24,710 --> 00:20:31,400
+الحسابي تعالوا شوفوا من اليوم الأول لليوم العاشرفي
+
+231
+00:20:31,400 --> 00:20:35,160
+اليوم الأول النقطة هي خط المين اللي بالمنتصف اللي
+
+232
+00:20:35,160 --> 00:20:39,980
+لونه أسود في اليوم الأول النقطة فوق خط المين اليوم
+
+233
+00:20:39,980 --> 00:20:44,020
+التاني النقطة برضه فوق خط المين من اليوم الأول
+
+234
+00:20:44,020 --> 00:20:48,340
+لليوم العاشر لو شفتوا النقاط كلها طالع فوق المين
+
+235
+00:20:48,340 --> 00:20:53,660
+مافيش ولا نقطة تحت هذه قاعدة اسمها 10XPAR هذه
+
+236
+00:20:53,660 --> 00:20:58,120
+القاعدة إن وجدت في نتائج الـcontrol بحكي عنها هي
+
+237
+00:20:58,120 --> 00:21:03,730
+rejected rule قاعدة مرفوضةوإن وجدت بيتنبهني إن في
+
+238
+00:21:03,730 --> 00:21:08,810
+عندي Systematic Error موجود في عندنا أخطاء منهجية
+
+239
+00:21:08,810 --> 00:21:14,230
+موجودة، تمام؟ These rules are violated when there
+
+240
+00:21:14,230 --> 00:21:18,750
+are 10 consecutive quality control results for one
+
+241
+00:21:18,750 --> 00:21:23,410
+level of control are on one side of domain يعني لو
+
+242
+00:21:23,410 --> 00:21:26,410
+أنا اشتغلت هذه الرسمة اللي عندي على control واحد
+
+243
+00:21:26,410 --> 00:21:30,610
+سواء normal أو abnormal، اشتغلت عليهطلعت عشر نتائج
+
+244
+00:21:30,610 --> 00:21:34,550
+في عشر أيام متتالية كلها فوق المين أو كلها تحت
+
+245
+00:21:34,550 --> 00:21:39,730
+المين تمام النقطة التانية هنحكي فيها على ال slide
+
+246
+00:21:39,730 --> 00:21:44,130
+اللي بعدها هذه القاعدة تفاجنا الـ Systematic Error
+
+247
+00:21:44,130 --> 00:21:50,990
+وRejected Rule تماملو انتبهنا على الرسمة اللي فوق
+
+248
+00:21:50,990 --> 00:21:56,910
+ماشية فقط Normal Control هي من اليوم الأول لليوم
+
+249
+00:21:56,910 --> 00:22:01,750
+العاشر لو انتبهتوا على النتائج وهي الـMean الـM هو
+
+250
+00:22:01,750 --> 00:22:06,200
+الـMean، هي خط الـMeanالعشر نتائج كلها تحت خط
+
+251
+00:22:06,200 --> 00:22:10,200
+المين الرسمة اللي جابلها كانت العشر نتائج كلها فوق
+
+252
+00:22:10,200 --> 00:22:15,820
+خط المين صحيح هذا كله قاعدة اسمها قاعدة العشرة X
+
+253
+00:22:15,820 --> 00:22:20,260
+bar طيب لو أنا في اليوم الواحد مشيت controlين
+
+254
+00:22:20,260 --> 00:22:24,460
+normal و abnormal يعني في اليوم الواحد حصلت على
+
+255
+00:22:24,460 --> 00:22:30,850
+نتجتين تمام؟ نشوف الرسمة اللي تحتفي اليوم الأول
+
+256
+00:22:30,850 --> 00:22:35,230
+اشتغل Ctrl 2 وبالتالي حصل على نتاج 2 اللون الـ
+
+257
+00:22:35,230 --> 00:22:38,830
+mauve والأخضر في اليوم التاني اشتغل برضه Ctrl 2
+
+258
+00:22:38,830 --> 00:22:44,770
+وفي اليوم التالت والرابع والخامس إذا خلال خمس أيام
+
+259
+00:22:44,770 --> 00:22:50,150
+متتالية في كل يوم اشتغل Ctrl 2 وبالتالي حصل على
+
+260
+00:22:50,150 --> 00:22:56,810
+نتاج 2 فلو عدينا النتائج هيطلع عشر نتائج خلال خمس
+
+261
+00:22:56,810 --> 00:23:03,250
+أياملأنه كل يوم حصل على نتاشتين فخلال خمس أيام كان
+
+262
+00:23:03,250 --> 00:23:08,650
+حاصل على عشر نتائج والعشر نتائج لو انتبهتوا كلهم
+
+263
+00:23:08,650 --> 00:23:13,210
+فوق خط المين هاي الـM هي المين والعشر نتائج كلها
+
+264
+00:23:13,210 --> 00:23:17,550
+فوق خط المين فهذه قاعدة تسمى العشرة X bar يعني
+
+265
+00:23:17,550 --> 00:23:23,580
+اللي بدي أعرفه سواء انت اشتغلتي Ctrl 1أو اشتغل كـ
+
+266
+00:23:23,580 --> 00:23:30,330
+Controllant بنفس اليوم تنطبق عليهم نفس القاعدةهنا
+
+267
+00:23:30,330 --> 00:23:35,410
+فقط يعني نظام مراجعة هو عامل مراجعة بس أربع قواعد
+
+268
+00:23:35,410 --> 00:23:39,810
+الواحد تلاتة أس اتفجنا نتيجة واحدة من نتائج ال
+
+269
+00:23:39,810 --> 00:23:43,690
+control برا التلاتة أس هنا حاطط النقطة اللي
+
+270
+00:23:43,690 --> 00:23:48,570
+بالدائرة تحت السالد تلاتة أس لو طلعتلكم إياها فوق
+
+271
+00:23:48,570 --> 00:23:53,440
+الموجة بتلاتة أس برضه صح تمام؟القاعدة التانية
+
+272
+00:23:53,440 --> 00:23:57,600
+اتنين اتنين أس في يومين متتاليين اليوم التاني
+
+273
+00:23:57,600 --> 00:24:02,580
+والتالت طلعت عندي نتجتين فوق الموجة باتنين شفتوا؟
+
+274
+00:24:02,580 --> 00:24:06,080
+هي الموجة باتنين وهي النقطتين معلم عليهم أو لو
+
+275
+00:24:06,080 --> 00:24:10,660
+حطيتلكم النقطتين تحت السالب اتنين أس تحت خط السالب
+
+276
+00:24:10,660 --> 00:24:18,100
+اتنين أس برضه صحتمام القاعدة التالتة الـ R4S قلنا
+
+277
+00:24:18,100 --> 00:24:25,600
+إنه في اليوم الخامس مخلي نتيجة تحت السالب 2 تحت خط
+
+278
+00:24:25,600 --> 00:24:30,560
+السالب 2 وفي اليوم السادس مخلي النتيجة فوق الموجة
+
+279
+00:24:30,560 --> 00:24:35,040
+2 إذا واحدة تحت السالب 2 وواحدة فوق الموجة 2 إذا
+
+280
+00:24:35,040 --> 00:24:42,320
+هذه قاعدة الـ R4S تمامأخر إشي أربعة واحد يعني أربع
+
+281
+00:24:42,320 --> 00:24:48,360
+أيام متتالية اليوم السابع التامن التاسع العاشر هاي
+
+282
+00:24:48,360 --> 00:24:53,140
+في اليوم السابع نتيجتي تحت السالب واحد هاي خط
+
+283
+00:24:53,140 --> 00:24:58,260
+السالب واحد اللي لونه أخضر هاي تحته في اليوم
+
+284
+00:24:58,260 --> 00:25:03,700
+التامن في خطأ في النقطة بطلب منكم تمسحوا النقطة
+
+285
+00:25:03,700 --> 00:25:09,900
+هذه اللي فوقنقطة رقم تمانية واتنزلوها تحت السالب
+
+286
+00:25:09,900 --> 00:25:14,100
+واحد انتوا بالملزمة هتمسحوها واتنزليها تحت السالب
+
+287
+00:25:14,100 --> 00:25:17,460
+واحد لإنها لازم تكون تحت السالب واحد في اليوم
+
+288
+00:25:17,460 --> 00:25:21,620
+التاسع النقطة هيها تحت السالب واحد تحت خط السالب
+
+289
+00:25:21,620 --> 00:25:25,500
+واحد في اليوم العاشر برضه نقطة تحت خط السالب واحد
+
+290
+00:25:25,500 --> 00:25:32,440
+إذا انت تنطبق عليهم قاعدة 41Sعندي فيه شغلات أخطأ
+
+291
+00:25:32,440 --> 00:25:37,660
+ممكن أنا يعني لما أرسم نتائج الـ Control أن تبهلها
+
+292
+00:25:37,660 --> 00:25:42,880
+وأحكي والله هنا فيه خطأ عندي فيه مشكلة تسمى مشكلة
+
+293
+00:25:42,880 --> 00:25:48,300
+الـ Shift، تمام؟ Shift معناها تنزاح القيم لجهة
+
+294
+00:25:48,300 --> 00:25:53,470
+معينة، تمام؟نشوف شو تعريف الـ Shift الـ Shift is a
+
+295
+00:25:53,470 --> 00:25:58,030
+sudden consistent change in values in either side
+
+296
+00:25:58,030 --> 00:26:02,930
+of the mean بكل بساطة بتشوفي مجموعة من نتائج الـ
+
+297
+00:26:02,930 --> 00:26:07,690
+control كلها جاية إما كلها فوق الـ mean أو كلها
+
+298
+00:26:07,690 --> 00:26:11,290
+تحت الـ mean مش كل النتائج يعني بتلاقيلك مثلا عشر
+
+299
+00:26:11,290 --> 00:26:17,070
+نتائج كلهم جايين فوق الـ meanأو عشر نتائج كلهم تحت
+
+300
+00:26:17,070 --> 00:26:22,210
+الـ Main يعني بشكل مبسط مافي Distribution لنتائج
+
+301
+00:26:22,210 --> 00:26:26,330
+الـ Control على الـ Curve يفترض النتائج ستتوزع جزء
+
+302
+00:26:26,330 --> 00:26:30,550
+منها يطلع فوق الـ Main وجزء منها تحت الـ Main لكن
+
+303
+00:26:30,550 --> 00:26:34,770
+في الـ Shift بلاجة في انزياح يعني أن القيم بتنزاح
+
+304
+00:26:34,770 --> 00:26:41,010
+تنزاح لجهة معينة من الـ Main إما فوقه أو تحتهتمام؟
+
+305
+00:26:41,010 --> 00:26:45,890
+Quality control data results are distributed on
+
+306
+00:26:45,890 --> 00:26:51,030
+one side of the meme for 6 ل7 consecutive days
+
+307
+00:26:51,030 --> 00:26:58,710
+يعني لو لجيتيخلال ست لسبع أيام متتالية يعني سبع
+
+308
+00:26:58,710 --> 00:27:04,130
+أيام متتالية لجيت في السبع أيام سبع نتائج كانت
+
+309
+00:27:04,130 --> 00:27:08,570
+كلها فوق المين أو كلها تحت المين بحكي والله عندي
+
+310
+00:27:08,570 --> 00:27:13,490
+مشكلة shift في النتائج عندي نتائج بتنزح إما كلها
+
+311
+00:27:13,490 --> 00:27:18,710
+فوق أو تحت وهذه مشكلة، تمام؟هذا بيسموه الـ Shift
+
+312
+00:27:18,710 --> 00:27:24,650
+لو جينا على الرسمة شوفولي من اليوم العاشر لليوم
+
+313
+00:27:24,650 --> 00:27:30,710
+التلاتين من اليوم العاشر لليوم التلاتين لو جيت على
+
+314
+00:27:30,710 --> 00:27:37,250
+ال X bar خط المين الموف هذا وجسمته هي انجسم انتبهي
+
+315
+00:27:37,250 --> 00:27:42,990
+من اليوم العاشر لليوم التلاتين كل النقاط فوق خط
+
+316
+00:27:42,990 --> 00:27:48,060
+المينكل النقاط فوق خط المين مافيش ولا نقطة نازلة
+
+317
+00:27:48,060 --> 00:27:55,450
+تحت معناه في عندي shift في إزاحة للقيم تمام؟أما
+
+318
+00:27:55,450 --> 00:28:00,650
+بالنسبة لمشكلة أخرى ممكن نشوفها هي الـ Trend الـ
+
+319
+00:28:00,650 --> 00:28:04,230
+Trend إيش تعريفه؟ is a gradual decrease or
+
+320
+00:28:04,230 --> 00:28:08,090
+increase in the values in either side of the mean
+
+321
+00:28:08,090 --> 00:28:15,830
+بنشوف ذيادة أو نقصان تدريجي في القيم كيف؟ مثلا
+
+322
+00:28:15,830 --> 00:28:26,260
+تعالوا انتبهوا معيمن اليوم العاشر لليوم العشرين من
+
+323
+00:28:26,260 --> 00:28:32,220
+اليوم العاشر لليوم العشرين ايش بتشوفوا القيم القيم
+
+324
+00:28:32,220 --> 00:28:36,680
+جاية من المين وانزل لتحت يعني في عندي gradual
+
+325
+00:28:36,680 --> 00:28:42,040
+decrease بدأت تنزل تحت المين وعمل زي انحضار زي ما
+
+326
+00:28:42,040 --> 00:28:46,020
+احنا شايفين منحضر لتحت هذا بيسموه trend gradual
+
+327
+00:28:46,020 --> 00:28:51,810
+decreaseبشكل تدريجي القيم ماشية كأنها ماشية باتجاه
+
+328
+00:28:51,810 --> 00:28:56,610
+النقصان، تمام؟ أو ممكن لو رسمنا رسمة أخرى أو
+
+329
+00:28:56,610 --> 00:29:02,590
+increase، يعني من من المين نفسه ترسمي خط لفوق،
+
+330
+00:29:02,590 --> 00:29:06,510
+القيم تمشي لفوق، يعني إما هذه خط المين، إما
+
+331
+00:29:06,510 --> 00:29:12,120
+النتائج تلاقيها،من المين ونازلة لتحت بشكل منحدر أو
+
+332
+00:29:12,120 --> 00:29:18,040
+من المين وطالعة لفوق بشكل يعني ترضي القيام طالعة
+
+333
+00:29:18,040 --> 00:29:23,700
+لفوق هذه بيسموها الـ Trend طيب، بحكي للقاعدةخلال
+
+334
+00:29:23,700 --> 00:29:28,500
+سبع أيام لو لجيتي سبع نتائج إما ماشية باتجاه
+
+335
+00:29:28,500 --> 00:29:32,960
+النقصان أو طالعة بالزيادة معناها هذا شكل ال trend
+
+336
+00:29:32,960 --> 00:29:38,360
+كتير مميز إما علاقة تحت لتحت ماشية أو نقاط طالعة
+
+337
+00:29:38,360 --> 00:29:45,870
+لفوق يعني في الزيادة، تمام؟أما بالنسبة للـ
+
+338
+00:29:45,870 --> 00:29:50,950
+dispersion آخر مشكلة معناه التشطط بيحكيلي values
+
+339
+00:29:50,950 --> 00:29:54,510
+maybe within the acceptable range but are
+
+340
+00:29:54,510 --> 00:29:59,490
+uneventfully distributed outside the plus minus
+
+341
+00:29:59,490 --> 00:30:03,950
+واحد S limits ال dispersion لو انت طلعتي على كل
+
+342
+00:30:03,950 --> 00:30:11,030
+نتائج ال control بتكون ضمن ال X bar موجب أو ناقص
+
+343
+00:30:11,030 --> 00:30:17,150
+لتنين SD يعني كل نتائجمقبولة ضمن الـ Range بس وين
+
+344
+00:30:17,150 --> 00:30:22,990
+في مشكلة في تشتت القيم الكتير أو النقاط نتائج الـ
+
+345
+00:30:22,990 --> 00:30:27,570
+Control بعيدة عن الـ Mean و بعيدة عن بعضها البعض
+
+346
+00:30:27,570 --> 00:30:31,130
+في dispersion على الرغم من إنها واجعة في الـ
+
+347
+00:30:31,130 --> 00:30:35,780
+Normal Range إذن بدنا نفهمإن كل القيم موجودة ضمن
+
+348
+00:30:35,780 --> 00:30:41,520
+الـ Normal Range الـ X bar موجب أو –2SD لكن في
+
+349
+00:30:41,520 --> 00:30:47,300
+مشكلة في القيم إنها متناثرة متشتتة بعيدة عن الـ
+
+350
+00:30:47,300 --> 00:30:53,260
+Main السببThis is indicating هذا مؤشر على وجود فقد
+
+351
+00:30:53,260 --> 00:30:57,420
+الـ precision فقد الإحكام والضقة في ال kit اللي
+
+352
+00:30:57,420 --> 00:31:02,060
+أنا بشتغله للفحص أو مشكلة إنه حدث Indic Random
+
+353
+00:31:02,060 --> 00:31:07,100
+Error عمل هذا التشتت سواء المشكلة في ال precision
+
+354
+00:31:07,540 --> 00:31:13,840
+أو هناك زيادة في الـ Random Error في الشغل هذا كله
+
+355
+00:31:13,840 --> 00:31:19,580
+What Cause هذا كله هيؤدي إلى حدوث زيادة في الـ
+
+356
+00:31:19,580 --> 00:31:22,580
+Standard Deviation للقيم لما تيجي تحسبي الـ
+
+357
+00:31:22,580 --> 00:31:26,960
+Standard Deviation بطلع كتير عالي مقدار الانحراف
+
+358
+00:31:28,130 --> 00:31:32,010
+طيب لو مقدار التشتت طلع عالي كتير معناه القيم
+
+359
+00:31:32,010 --> 00:31:36,570
+هتبعد عن الـ mean تمام؟ وبالتالي يصير في
+
+360
+00:31:36,570 --> 00:31:41,630
+dispersion تشتت هذه القيم لو انتبهتي على الرسمة من
+
+361
+00:31:41,630 --> 00:31:48,030
+اليوم الأول لليوم التلاتين كل قيمة محصورة بين الـ
+
+362
+00:31:48,030 --> 00:31:53,290
+X bar موجب أو ناقص لـ2S يعني هي قيمة أو قنتين أو
+
+363
+00:31:53,290 --> 00:31:58,670
+تلاتة فوقلكن لو كنظرة أولى هتحس القيم فيها
+
+364
+00:31:58,670 --> 00:32:03,850
+dispersion فيها تشطط و بعيدة عن المين تمام؟
+
+365
+00:32:03,850 --> 00:32:04,830
+يعطيكوا العافية
+
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/GY2MTVi93So.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/GY2MTVi93So.srt
new file mode 100644
index 0000000000000000000000000000000000000000..8aef496c0e824a2a8d5e0599f671385f26d9150d
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/GY2MTVi93So.srt
@@ -0,0 +1,1638 @@
+1
+00:00:00,930 --> 00:00:04,530
+السلام عليكم ورحمة الله وبركاته يعطيكم العافية
+
+2
+00:00:04,530 --> 00:00:08,270
+جميعا إن شاء الله اليوم موضوعنا بعنوان Cardiac
+
+3
+00:00:08,270 --> 00:00:12,170
+Profile Test فحوصات تشيك على وضع عضلة القلب
+
+4
+00:00:15,030 --> 00:00:25,190
+القلب هو عبارة
+
+5
+00:00:25,190 --> 00:00:30,730
+عن عضلة مسئولة عن ضخ الدم لجميع أعضاء الجسم من
+
+6
+00:00:30,730 --> 00:00:35,910
+خلال blood vessels من خلال الأوردة والشرايين طبعا
+
+7
+00:00:35,910 --> 00:00:41,530
+القلب بيستطيع أنه يدفع الدم من خلال الـContraction
+
+8
+00:00:41,530 --> 00:00:46,350
+اللي بتسير له من خلال عملية الانقباض، الانقباض
+
+9
+00:00:46,350 --> 00:00:52,630
+لهذه العضلة هو اللي بيخلي القلب يدفع الدم لجميع
+
+10
+00:00:52,630 --> 00:00:58,010
+أعضاء الجسم. الـ Rule of Laboratory يعني أهمية
+
+11
+00:00:58,010 --> 00:01:02,430
+الفحوصات المخبرية. واحد، a cystic cardiac disease
+
+12
+00:01:02,430 --> 00:01:06,710
+such as acute myocardial infarction يعني من خلال
+
+13
+00:01:06,710 --> 00:01:10,850
+الفحوصات الكيميائية إحنا بنقدر نحكي هل هذا الشخص
+
+14
+00:01:10,850 --> 00:01:14,940
+مصاب بأمراض القلب. ومن هذه الأمراض الـ acute
+
+15
+00:01:14,940 --> 00:01:20,700
+myocardial infarction، الـ AMI، الذبحة القلبية، تمام؟
+
+16
+00:01:20,700 --> 00:01:24,040
+إذا أنا من خلال الفحوصات الكيميائية بقدر أحكي هل
+
+17
+00:01:24,040 --> 00:01:28,920
+هذا الشخص مصاب بالـ AMI or not. Offer body chemistry
+
+18
+00:01:28,920 --> 00:01:32,860
+information to aid supportive cardiac therapy.
+
+19
+00:01:32,860 --> 00:01:38,240
+أيضًا من خلال الفحوصات الكيميائية ممكن تساعدنا في
+
+20
+00:01:38,240 --> 00:01:43,300
+متابعة الأشخاص اللي عندهم مشاكل في القلب. يعني ثبت
+
+21
+00:01:43,300 --> 00:01:46,800
+أن الشخص عنده مشكلة في عضلة القلب، أكيد هيعطيه
+
+22
+00:01:46,800 --> 00:01:51,630
+الدكتور therapy، هيعطيه علاج، تمام؟ عشان أتابع هل
+
+23
+00:01:51,630 --> 00:01:56,150
+العلاج أعطى نتيجة ولا لأ، لابد من إجراء الفحوصات
+
+24
+00:01:56,150 --> 00:02:00,570
+الكيميائية، تمام؟ إذا ملاحظة: single diagnostic
+
+25
+00:02:00,570 --> 00:02:03,610
+laboratory test that assess cardiac function
+
+26
+00:02:03,610 --> 00:02:08,210
+doesn't exist. يعني هذه الجملة مش بس لفحوصات اللي
+
+27
+00:02:08,210 --> 00:02:12,810
+بتشيكلي على عضلة القلب، تمام؟ عشان أنا بدي أشيك على
+
+28
+00:02:12,810 --> 00:02:18,030
+عضلة القلب، يعني ما بنفع أعمل فحص واحد لحاله، يفضل
+
+29
+00:02:18,030 --> 00:02:23,030
+نعمل فحصين أو أكثر. مش بس لعضلة القلب، لو أنا بدي
+
+30
+00:02:23,030 --> 00:02:27,870
+أشيك على وضع الكلى أو على وضع الكبد، liver زي ما
+
+31
+00:02:27,870 --> 00:02:32,710
+أخذنا، تمام؟ لازم أعمل أكثر من فحص، مش أكتفي بفحص
+
+32
+00:02:32,710 --> 00:02:38,170
+واحد. فحص واحد مش كافي أنه يشيكلي على وضع عضلة
+
+33
+00:02:38,170 --> 00:02:39,310
+القلب، تمام؟
+
+34
+00:02:42,350 --> 00:02:46,570
+الـ Cardiac Marker، الفحوصات اللي بتشيك على وضع
+
+35
+00:02:46,570 --> 00:02:51,810
+عضلة القلب. أول شغلة هي عبارة عن إنزيمات، تمام؟ إذا
+
+36
+00:02:51,810 --> 00:02:56,070
+الفحوصات اللي بتشيك على وضع عضلة القلب هي عبارة عن
+
+37
+00:02:56,070 --> 00:03:02,130
+enzymes. هناك ثلاث إنزيمات مسؤولة عن التشيك على
+
+38
+00:03:02,130 --> 00:03:09,740
+وضع عضلة القلب. أول enzyme، الـ AST أو الاسم الآخر
+
+39
+00:03:09,740 --> 00:03:14,440
+له، لو حكينا الـ GOT، إذا فاكرين، أو As Got، بيحكوا
+
+40
+00:03:14,440 --> 00:03:18,200
+عنه، ضعوا حرف الـ S في البداية، S جاية من Serum
+
+41
+00:03:18,200 --> 00:03:22,280
+وكلمة GOT أخذنا اختصارها قبل هيك لما أخذنا
+
+42
+00:03:22,280 --> 00:03:26,780
+الفحوصات اللي بتشيك على وضع عضلة الكبد، حكينا أن الـ
+
+43
+00:03:26,780 --> 00:03:31,000
+AST موجود في الكبد، هذا الـ enzyme، خلايا الكبد
+
+44
+00:03:31,000 --> 00:03:37,500
+بتفرزه، تمام؟ أيضًا الـ AST بدنا نفهم أنه موجود في
+
+45
+00:03:37,500 --> 00:03:41,480
+عضلة القلب، مكانه الأساسي في عضلة القلب، هو موجود في
+
+46
+00:03:41,480 --> 00:03:45,260
+الدم، ولكن at low concentration، الوضع الطبيعي أن
+
+47
+00:03:45,260 --> 00:03:49,200
+الـ AST بيكون موجود بالدم، ولكن بتركيز قليل جدًا
+
+48
+00:03:49,200 --> 00:03:53,640
+لكن مكانه الأصلي في عضلة القلب. الـ Aspartate
+
+49
+00:03:53,640 --> 00:03:57,900
+Transaminase. الإنزيم الثاني، الـ Lactate
+
+50
+00:03:57,900 --> 00:04:03,440
+Dehydrogenase أو الاختصار تبعه الـ LDH أو في ناس
+
+51
+00:04:03,440 --> 00:04:09,720
+بتحكي LD وخلاص، تمام؟ سواء كتبنا LD أو LDH هو الـ
+
+52
+00:04:09,720 --> 00:04:14,280
+Lactate Dehydrogenase. هذا الإنزيم فيه منه five
+
+53
+00:04:14,280 --> 00:04:20,320
+isoenzymes، فيه منه خمس نظائر، وكل نظير منه بيكون
+
+54
+00:04:20,320 --> 00:04:26,380
+موجود بعضو معين في الجسم، تمام؟ زي ما نشوف .. زي ما
+
+55
+00:04:26,380 --> 00:04:30,320
+هنشوف إن شاء الله بالـ slides القادمة. هذه الخمسة
+
+56
+00:04:30,320 --> 00:04:35,840
+iso-enzyme composed of combination of H and M
+
+57
+00:04:35,840 --> 00:04:42,080
+subunits. كل نظير بتكون من two subunits، من وحدتين،
+
+58
+00:04:42,080 --> 00:04:48,270
+هادول الوحدتين هي الـ H والـ M.  «H» جاية من كلمة
+
+59
+00:04:48,270 --> 00:04:53,210
+«heart»، إنه هذا النظير طالع من عضلة القلب، أو هذا
+
+60
+00:04:53,210 --> 00:04:59,050
+الـ enzyme أصلا هو موجود في عضلة القلب. كلمة «M» من
+
+61
+00:04:59,050 --> 00:05:03,550
+«muscle»، إنه هذا النظير أو هذا الـ enzyme أصله في
+
+62
+00:05:03,550 --> 00:05:07,830
+الـ muscle، أصله في العضلات، موجود في العضلات. هنفهم
+
+63
+00:05:07,830 --> 00:05:12,300
+هذا الكلام بالـ slides الجاية. الثالث إنزيم الـ
+
+64
+00:05:12,300 --> 00:05:17,560
+Creatine Kinase اللي هو الـ CK، اختصاره CK. هذا
+
+65
+00:05:17,560 --> 00:05:22,740
+ال إنزيم فيه منه ثلاث نظائر، وكل نظير بيكون موجود
+
+66
+00:05:22,740 --> 00:05:27,620
+بمكان معين في الجسم، بعضو معين. هذه النظائر
+
+67
+00:05:28,590 --> 00:05:33,110
+composed of combination of N and B subunits. كل
+
+68
+00:05:33,110 --> 00:05:38,470
+نظير بتكون من two subunits، من الـ N ومن الـ B. كلمة N
+
+69
+00:05:38,470 --> 00:05:43,130
+يعني جاية من الـ muscle، وكلمة B يعني جاية من الـ brain،
+
+70
+00:05:43,130 --> 00:05:47,540
+من الدماغ. أن هذا الـ enzyme موجود في الدماغ، أو ممكن
+
+71
+00:05:47,540 --> 00:05:52,220
+هذا النظير أشوفه في الـ Muscle، تمام؟ هنفهم قصة
+
+72
+00:05:52,220 --> 00:05:55,860
+النظائر في الـ slides الجاية. بس أهم شيء من هذه
+
+73
+00:05:55,860 --> 00:05:59,660
+الـ slide بدنا نطلع أنه أنا في عندي ثلاث إنزيمات
+
+74
+00:05:59,660 --> 00:06:04,560
+بتشيك على وظائف عضلة القلب أو بتشيك على عضلة القلب
+
+75
+00:06:04,560 --> 00:06:08,680
+الـ AST، والـ LDH، والـ CK، تمام؟
+
+76
+00:06:12,460 --> 00:06:17,120
+Lactate Dehydrogenase. أول marker بدنا نحكي فيه
+
+77
+00:06:17,120 --> 00:06:22,660
+وأول فحص بيشيك على وضع عضلة القلب، اختصاره LD أو
+
+78
+00:06:22,660 --> 00:06:26,760
+LDH. هذا الإنزيم كلنا عارفين بيحول البيروفات
+
+79
+00:06:26,760 --> 00:06:31,020
+للاكتات، والـ NADH إلى NAD، أو العكس، يعني التفاعل
+
+80
+00:06:31,020 --> 00:06:35,620
+بيمشي بشكل عكسي، reversible، بيحول اللاكتات لبيروفات
+
+81
+00:06:35,620 --> 00:06:40,920
+والـ NAD إلى NADH. إذا أنا من خلال المعادلة بقدر
+
+82
+00:06:40,920 --> 00:06:46,900
+أستنتج أن الكتات اللي موجودة في المختبر واللي بتقيس
+
+83
+00:06:46,900 --> 00:06:53,200
+نشاط الـ «إنزايم» تعتمد على قياس الـ «absorbance»
+
+84
+00:06:53,200 --> 00:07:00,060
+لمركب الـ NAD، قد إيش عند 340، يعني في منطقة الـ «UV». الـ
+
+85
+00:07:00,060 --> 00:07:04,540
+«activity is measured»، يعني تركيز أو نشاط الـ
+
+86
+00:07:04,540 --> 00:07:10,300
+«إنزيم» بتم قياسه من خلال قياس ومتابعة الـ
+
+87
+00:07:10,300 --> 00:07:16,200
+«absorbance» عند 340، لأن خلال التفاعل بيتكون عندي
+
+88
+00:07:16,200 --> 00:07:21,820
+مركب الـ NADH، والـ NADH هذا بيصير له امتصاص عند
+
+89
+00:07:21,820 --> 00:07:27,840
+ثلاثمية وأربعين، وامتصاصه يعبر عن نشاط الـ enzyme
+
+90
+00:07:27,840 --> 00:07:35,370
+في العينة، تمام؟ النقطة الثانية، methods can be: من
+
+91
+00:07:35,370 --> 00:07:40,770
+بيروفات اللي بيختصر لبيروفات، من بيروفات للاكتات، or
+
+92
+00:07:40,770 --> 00:07:45,650
+لاكتات لبيروفات. The reference range is different.
+
+93
+00:07:45,650 --> 00:07:52,170
+إيش قصده بهذه الجملة؟ جماعة في كتّاب بتقيس، بتقيس
+
+94
+00:07:52,170 --> 00:07:57,430
+كيف؟ بشكل forward، يعني التفاعل ماشي زي المعادلة
+
+95
+00:07:57,430 --> 00:08:01,310
+اللي أمامنا، إنه الـ enzyme، lactate dehydrogenase
+
+96
+00:08:01,310 --> 00:08:04,110
+بيكون موجود في عينة الـ patients، صح ولا لأ؟ أنا بدي
+
+97
+00:08:04,110 --> 00:08:08,810
+أقيس نشاطه، الـ enzyme. الـ reaction بيكون فيه بيروفيت،
+
+98
+00:08:08,810 --> 00:08:13,140
+تمام؟ فالـ enzyme اللي موجود في عينة المريض،
+
+99
+00:08:13,140 --> 00:08:17,260
+لما بأخلطه على الـ reagent هيحول الـ pyruvate لـ
+
+100
+00:08:17,260 --> 00:08:22,820
+lactate، والـ NADH إلى NAD. فهنا إحنا هنقيس الـ
+
+101
+00:08:22,820 --> 00:08:26,260
+reduction في الـ absorbance، القلة في الـ
+
+102
+00:08:26,260 --> 00:08:29,520
+absorbance، لأن كلنا عارفين من NADH لـ NAD الـ
+
+103
+00:08:29,520 --> 00:08:36,040
+absorbance هيقل، تمام؟ لكن في كتّاب أخرى بتقيس نشاط
+
+104
+00:08:36,040 --> 00:08:41,830
+الـ enzyme، ولكن بشكل reversible، كيف؟ عينة المريض
+
+105
+00:08:41,830 --> 00:08:45,110
+فيها lactate dehydrogenase، فيها الإنزيم اللي أنا
+
+106
+00:08:45,110 --> 00:08:49,670
+بدي أقيس نشاطه، تمام؟ الـ reagent ما بيكون فيه
+
+107
+00:08:49,670 --> 00:08:52,770
+بيروفيت، ها إيش بيكون فيه؟ بيكون فيه لاكتات.
+
+108
+00:08:52,770 --> 00:08:56,630
+فالـ Lactate Dehydrogenase، الإنزيم اللي موجود في
+
+109
+00:08:56,630 --> 00:09:00,970
+العينة بيشتغل على اللاكتات اللي موجود في الـ reagent،
+
+110
+00:09:00,970 --> 00:09:08,340
+وبيحوله لبيروفيت، وبيحول الـ NAD إلى NADH. هنقيس
+
+111
+00:09:08,340 --> 00:09:12,820
+الزيادة في الـ absorbance، تمام؟ لأن لو الـ NAD
+
+112
+00:09:12,820 --> 00:09:17,780
+اتحولت لـ NADH، الـ absorbance هيزيد، تمام؟ هي
+
+113
+00:09:17,780 --> 00:09:23,250
+الفقرة الثانية، هيك فكرتها، إنه في كتّاب يعني
+
+114
+00:09:23,250 --> 00:09:27,650
+الـ reagent بيكون فيها pyruvate، تمام؟ وفي كتّاب
+
+115
+00:09:27,650 --> 00:09:31,090
+الـ reagent بيكون فيها lactate، يعني يا إن التفاعل
+
+116
+00:09:31,090 --> 00:09:35,630
+بمشي forward أو بمشي reverse، في المحصلة أنت
+
+117
+00:09:35,630 --> 00:09:40,450
+بالأخر هتحصل على نشاط الـ enzyme، تركيز الـ enzyme
+
+118
+00:09:40,450 --> 00:09:44,880
+في العينة، تمام؟ طبعا كل كتّاب يا جماعة لها reference
+
+119
+00:09:44,880 --> 00:09:50,280
+range مختلفة، normal range مختلفة. Total LD activity
+
+120
+00:09:50,280 --> 00:09:57,670
+has poor specificity. إيش قصده؟ هل جيت؟ حكيت لكم إنه
+
+121
+00:09:57,670 --> 00:10:02,310
+اللاكتات ديهايدروجينيز هذا الإنزيم فيه منه خمسة
+
+122
+00:10:02,310 --> 00:10:06,410
+isoenzyme. يعني هل جيت لو أخذت منك serum، تمام؟ في
+
+123
+00:10:06,410 --> 00:10:10,570
+الـ serum تبعك، في الدم تبعك، في بلازما الدم فيه
+
+124
+00:10:10,570 --> 00:10:17,790
+خمسة isoenzyme، فيه خمس نظائر، فيه LD1 و LD2 و LD3
+
+125
+00:10:17,790 --> 00:10:24,210
+و LD4 و LD5، تمام؟ كل هدول إنزيمات، ولكن هي نظائر،
+
+126
+00:10:24,210 --> 00:10:28,590
+يعني بتشارك مع بعضها البعض وبتختلف اختلافات بسيطة
+
+127
+00:10:28,590 --> 00:10:32,950
+بين بعضها البعض، تمام؟ إذًا كل إنسان الوضع الطبيعي
+
+128
+00:10:32,950 --> 00:10:39,770
+في الدم تبعه فيه خمس نظائر، فيه LD1 و LD2 و LD3 و LD4
+
+129
+00:10:39,770 --> 00:10:46,380
+و LD5، تمام؟ هدول مع بعض اسمهم Total LD، هم كل
+
+130
+00:10:46,380 --> 00:10:50,980
+اللاكتات ديهايدروجينيز. الـ Total يعني الكتّاب،
+
+131
+00:10:50,980 --> 00:10:54,840
+الكتّاب اللي فعليًا موجودة عندنا بالمختبر، بقيس الـ
+
+132
+00:10:54,840 --> 00:11:00,700
+Total LDH، بقيس LD1 زائد، LD2 زائد، LD3 زائد، LD4
+
+133
+00:11:00,700 --> 00:11:06,540
+زائد، LD5. بقيس كل الـ isoenzyme اللي موجودة في
+
+134
+00:11:06,540 --> 00:11:12,100
+الدم، تمام؟ للأسف هذا الفحص إحنا بنسميه Total LD،
+
+135
+00:11:12,100 --> 00:11:16,040
+يعني بيقيس كل الـ isoenzyme، بيجمعهم مع بعض. للأسف
+
+136
+00:11:16,040 --> 00:11:21,780
+هذا الفحص يعني مش متخصص، مش specific، ليش؟ لو
+
+137
+00:11:21,780 --> 00:11:25,900
+اجاني مريض، بدنا نركز، لو اجاني مريض وفحصت له Total
+
+138
+00:11:25,900 --> 00:11:30,200
+LDH وطلع عالي، عالي كتير، هذا بيعطيك indication
+
+139
+00:11:30,200 --> 00:11:35,920
+لشو؟ بيعطيني indication فقط أن هذا المريض عنده
+
+140
+00:11:35,920 --> 00:11:41,200
+damage في عضو معين، عنده خراب في عضو معين، بس إيش
+
+141
+00:11:41,200 --> 00:11:46,200
+هو العضو اللي فيه المشكلة، ما بتقدر تعرفه، ليش؟
+
+142
+00:11:46,200 --> 00:11:50,940
+لأنّه بتكون تعرف أن الخمسة isoenzyme، الخمس نظائر
+
+143
+00:11:50,940 --> 00:11:54,290
+اللي بتكون موجودة في الدم، موجودة في low
+
+144
+00:11:54,290 --> 00:11:58,090
+concentration. يعني معظم الإنزيمات بتكون موجودة في
+
+145
+00:11:58,090 --> 00:12:03,710
+الدم، ولكن بتركيز قليل. هذا الإنسان الطبيعي، لكن لو
+
+146
+00:12:03,710 --> 00:12:08,670
+اجاني شخص عملت له total LD، يعني فحصت له كل الخمسة
+
+147
+00:12:08,670 --> 00:12:13,270
+isoenzyme مع بعض وسجلت نتيجته وطلع عالية كتير،
+
+148
+00:12:13,270 --> 00:12:17,570
+معناه الكلام، إذا عالية الإنزيمات كتير، معناه في
+
+149
+00:12:17,570 --> 00:12:24,120
+عنده damage، لكن ما بعرف أي عضو حدث فيه الدمج، تمام؟
+
+150
+00:12:24,120 --> 00:12:29,920
+هي مشكلة فحص الـ Total LD، عشان هيك بيلجأوا لفحص
+
+151
+00:12:29,920 --> 00:12:34,480
+الـ electrophoresis، بياخذوا serum، وهذا الـ serum
+
+152
+00:12:34,480 --> 00:12:40,000
+بيفصل العينة أو بيفصل الـ isoenzyme، بيعطيك تركيز
+
+153
+00:12:40,000 --> 00:12:44,920
+الـ LD1 والـ LD2 والـ LD3 والـ LD4 والـ LD5، كل
+
+154
+00:12:44,920 --> 00:12:51,570
+واحد تركيزه على حدة، وبالتالي أنت بتعرفي أي نظير هو
+
+155
+00:12:51,570 --> 00:12:57,810
+العالي عند هذا المريض، وبالتالي إذا أنت حددت أي iso-
+
+156
+00:12:57,810 --> 00:13:02,890
+enzyme هو العالي، تقدر تعرفي وين الـ damage صار، في
+
+157
+00:13:02,890 --> 00:13:09,950
+أي عضو صار، تمام؟ عشان هيك فحص الـ Total LDH بحد
+
+158
+00:13:09,950 --> 00:13:17,110
+ذاته مش كتير بيفيدني، تمام؟ The specificity of LD
+
+159
+00:13:17,110 --> 00:13:22,750
+isoenzymes. بدنا نحكي عن الخمس إنزيمات اللي هم
+
+160
+00:13:22,750 --> 00:13:30,010
+النظائر، أسماؤهم: LD-1، LD-2، LD-3، LD-4، LD-5. هذه
+
+161
+00:13:30,010 --> 00:13:34,350
+النظائر، هذه النظائر الخمسة، هذه الإنزيمات الخمسة
+
+162
+00:13:34,350 --> 00:13:40,290
+بشكل أساسي موجودة في بلازما الدم وبتركيز قليل، هذا
+
+163
+00:13:40,290 --> 00:13:45,530
+عند الإنسان الطبيعي. وين هي موجودة بشكل أساسي؟ وين
+
+164
+00:13:45,530 --> 00:13:50,270
+مكانها؟ مكانها بتكون موجودة في أعضاء الجسم، ما بتكون
+
+165
+00:13:50,270 --> 00:13:53,630
+موجودة في البلازما. بتكون موجودة في البلازما، ولكن
+
+166
+00:13:53,630 --> 00:13:59,170
+بتركيز قليل. إتفاقنا أن الكتّاب اللي موجودة في المختبر
+
+167
+00:13:59,170 --> 00:14:04,930
+بتقيس الـ Total الـ LD، يعني بتقيس مجموع الـ isoenzyme
+
+168
+00:14:04,930 --> 00:14:09,310
+كلهم. الـ LD1 زائد الـ LD2 زائد الـ LD3 زائد
+
+169
+00:14:09,310 --> 00:14:14,350
+الـ LD4 زائد الـ LD5، بتعطيني تركيز، تركيزهم كلهم
+
+170
+00:14:14,350 --> 00:14:18,930
+مع بعض، تمام؟ عشان هيك سمّيناها total الـ LD، يعني بجمع
+
+17
+
+223
+00:18:59,760 --> 00:19:04,780
+العضلات، تمام؟ إذا هذه الـ subunits يعني بدنا نحفظ
+
+224
+00:19:04,780 --> 00:19:10,460
+مثلاً الـ LD1 إيش الرمز تبعه؟ أربعة H Indicator
+
+225
+00:19:10,460 --> 00:19:14,840
+لاقاش أنّه هو موجود أكثر شيء في عضلة القلب LD2 مكوّن
+
+226
+00:19:14,840 --> 00:19:22,020
+من 4 وحدات 3H و 1M و LD3 مكوّن من 4 وحدات 2H و 2M
+
+227
+00:19:22,020 --> 00:19:32,030
+LD4 مكوّن من 4M و 1H  LD5 مكوّن من 4M  الـ LD1 هو
+
+228
+00:19:32,030 --> 00:19:39,290
+أسرع
+
+229
+00:19:39,290 --> 00:19:45,610
+إنزيم ويمشي بشكل سريع باتجاه الـ positive باتجاه
+
+230
+00:19:45,610 --> 00:19:49,210
+الموجة، يعني باتجاه الأنود هذا وين؟ هدف الـ
+
+231
+00:19:49,210 --> 00:19:52,970
+Electrophoresis يعني لو فصلت هذه الإنزيمات على الـ
+
+232
+00:19:52,970 --> 00:19:56,070
+Cellulose acetate وهذا الكلام سنشتغله في الفصل
+
+233
+00:19:56,070 --> 00:20:03,810
+القادم ستجد أن الـ LD1 يمشي أسرع باتجاه الموجب يعني
+
+234
+00:20:03,810 --> 00:20:10,000
+أفهم شحنته بتكون موجبة تمام؟ الـ Diagnostic
+
+235
+00:20:10,000 --> 00:20:14,260
+Significance أهمية الفحص in healthy individuals
+
+236
+00:20:14,260 --> 00:20:19,240
+الـ LD2 is in highest quantity than الـ LD1، الـ LD3،
+
+237
+00:20:19,240 --> 00:20:24,580
+الـ LD4، and الـ LD5 في شغلتين عند الإنسان السليم
+
+238
+00:20:24,580 --> 00:20:30,180
+بدنا نعرفهم أول شغلة أن الخمسة isoenzymes الخمس
+
+239
+00:20:30,180 --> 00:20:35,360
+نظائر كلهم بيكونوا موجودين في بلازما الدم وبتركيز
+
+240
+00:20:35,360 --> 00:20:39,820
+قليل، هي أول معلومة، تمام؟ الشغل الثاني اللي بدنا
+
+241
+00:20:39,820 --> 00:20:47,120
+نعرفها أن الـLD2 موجود بأعلى تركيز من باقي النظائر
+
+242
+00:20:47,120 --> 00:20:52,880
+في بلازما الدم يعني كلهم تركيزهم قليل، تمام؟ بس
+
+243
+00:20:52,880 --> 00:20:57,500
+مين أعلى واحد فيهم في التركيز؟ الـLD2 زي ما هو
+
+244
+00:20:57,500 --> 00:21:04,030
+حكي لي في الفقرة أن الـLD2 موجود بتركيز أعلى من باقي
+
+245
+00:21:04,030 --> 00:21:09,470
+النظائر في بلازما الدم عشان هيك لو طلبت منكم
+
+246
+00:21:09,470 --> 00:21:16,150
+تجسموا لي تركيز الـLD1 على الـLD2 يعني بدي الـratio
+
+247
+00:21:16,150 --> 00:21:22,550
+لو طلبت منكم الـratio ما بين الـLD1 وLD2 هتطلع أقل
+
+248
+00:21:22,550 --> 00:21:31,040
+من 1 يعني لو جسمت تركيز LD1 على تركيز LD2 أنا متوقع
+
+249
+00:21:31,040 --> 00:21:37,160
+عند الإنسان الطبيعي تركيز LD2 أعلى من LD1 فلو جسمت
+
+250
+00:21:37,160 --> 00:21:42,740
+التركيز القليل تبع LD1 على التركيز الكبير اللي هو
+
+251
+00:21:42,740 --> 00:21:50,160
+الـLD2 محصلة القسمة الـratio هيطلع أقل من واحد
+
+252
+00:21:50,160 --> 00:21:57,780
+فتذكر LD1 على LD2 كله هيطلع أقل من واحد عند
+
+253
+00:21:57,780 --> 00:22:03,370
+الإنسان السليم تمام؟ الـHeart Problems في حال حدث
+
+254
+00:22:03,370 --> 00:22:09,430
+عندي مشكلة في عضلة القلب بيحكي لي أنه تركيز LD2
+
+255
+00:22:09,430 --> 00:22:16,430
+وLD1 لأن هذا الـisoenzyme حكينا LD1 وLD2 بشكل
+
+256
+00:22:16,430 --> 00:22:21,270
+أساسي موجودين في عضلة القلب فأي مشكلة في عضلة القلب
+
+257
+00:22:21,270 --> 00:22:26,030
+LD1 و LD2 عضلة القلب هيصير لها damage وبالتالي
+
+258
+00:22:26,030 --> 00:22:30,450
+هيصير لهم release هيطلع من عضلة القلب إلى البلازما
+
+259
+00:22:30,450 --> 00:22:35,910
+مادة وبالتالي LD1 و LD2 هيزيد تركيزهم في البلازما
+
+260
+00:22:35,910 --> 00:22:41,940
+مادة من 2 لـ 10 أضعاف الوضع الطبيعي يعني ممكن يرتفع
+
+261
+00:22:41,940 --> 00:22:47,340
+من اثنين لعشرة أضعاف الوضع الطبيعي لو صار عندي
+
+262
+00:22:47,340 --> 00:22:54,160
+heart problem تمام؟ إذا احنا في مشاكل القلب بنركز
+
+263
+00:22:54,160 --> 00:22:57,700
+على الـ two isoenzymes  الاثنين  لأن هما الاثنين اللي موجودين في عضلة القلب بتركيز
+
+264
+00:22:57,700 --> 00:23:02,160
+عالي تمام؟ if problem is not myocardial infarction
+
+265
+00:23:08,130 --> 00:23:13,490
+يعني لو كانت المشكلة مشكلة في القلب ولكن مش ذبحة
+
+266
+00:23:13,490 --> 00:23:19,670
+قلبية both LD1 و LD2 rise أكيد صار عندي مشكلة
+
+267
+00:23:19,670 --> 00:23:23,670
+في عضلة القلب تمام صار عندي مشكلة في عضلة القلب هيطلع
+
+268
+00:23:23,670 --> 00:23:28,370
+LD1 و LD2 من عضلة القلب لبلازما الدم وبالتالي
+
+269
+00:23:28,370 --> 00:23:34,210
+الاثنين هيزيدوا LD1 و LD2 في بلازما الدم هيزيدوا with
+
+270
+00:23:34,210 --> 00:23:40,170
+LD2 being greater than LD1 لكن LD2 هيظل تركيزه
+
+271
+00:23:40,170 --> 00:23:46,450
+أعلى من LD1، تمام؟ إذا في حال حدث عندي مشكلة في عضلة
+
+272
+00:23:46,450 --> 00:23:51,670
+القلب، تمام؟ ولكن هذه المشكلة مش ذبحة قلبية، إنما
+
+273
+00:23:51,670 --> 00:23:56,970
+مشاكل أخرى  النتيجة أن الـLD1 وLD2 هيطلعوا من القلب
+
+274
+00:23:56,970 --> 00:24:01,590
+للبلازما الدم وبالتالي الـLD2 هيرتفع  الـLD1 وLD2
+
+275
+00:24:01,590 --> 00:24:05,470
+هيزيدوا في بلازما الدم لكن بيحكي لي أن الـLD2
+
+276
+00:24:05,470 --> 00:24:12,850
+بيظل تركيزه أعلى من الـLD1، تمام؟ لكن لو كانت
+
+277
+00:24:12,850 --> 00:24:17,810
+المشكلة Myocardial Infarction، MI ذبحة قلبية
+
+278
+00:24:18,550 --> 00:24:24,150
+الاثنين هيطلعوا من عضلة القلب LD1 و LD2 بس إيش
+
+279
+00:24:24,150 --> 00:24:32,510
+بيحكي لي LD1 بتصير أعلى من LD2؟ ليش؟ مش عضلة القلب
+
+280
+00:24:32,510 --> 00:24:40,070
+فيها LD1 أكثر من LD2 هذه في عضلة القلب حكينا 60%
+
+281
+00:24:40,070 --> 00:24:46,470
+من الـ LD1 موجود في عضلة القلب و 30% من LD2 موجود
+
+282
+00:24:46,470 --> 00:24:51,110
+في عضلة القلب يعني في عضلة القلب جوا LD1 أعلى من
+
+283
+00:24:51,110 --> 00:24:58,020
+LD2 لكن في الدم LD2 أعلى من LD1 هذا الوضع الطبيعي
+
+284
+00:24:58,020 --> 00:25:03,980
+لو صار عندي دمج في عضلة القلب ذبحة قلبية LD1 و LD2
+
+285
+00:25:03,980 --> 00:25:09,720
+هيطلعوا بس LD1 كميته أكثر في عضلة القلب وبالتالي
+
+286
+00:25:09,720 --> 00:25:15,900
+هيطلع بشكل أكبر إلى الدم وبالتالي LD1 هيصير تركيزه
+
+287
+00:25:15,900 --> 00:25:22,430
+أعلى من LD2 في حالات الذبحة القلبية، تمام؟ عشان
+
+288
+00:25:22,430 --> 00:25:27,290
+هيك، كيف بتأكدوا أن هذا الشخص عنده ذبحة قلبية ولا
+
+289
+00:25:27,290 --> 00:25:35,010
+لأ، بيروح يجسم LD1 على LD2، تركيز LD1 على LD2،
+
+290
+00:25:35,010 --> 00:25:40,450
+في الذبحة القلبية، LD1 أعلى، وبالتالي، LD1
+
+291
+00:25:40,450 --> 00:25:44,470
+اللي تركيزه أعلى، لو جسمته على LD2 اللي تركيزه
+
+292
+00:25:44,470 --> 00:25:50,250
+أقل، إيش هتصير الـratio؟ هتصير أعلى من 1، تمام؟
+
+293
+00:25:50,930 --> 00:25:58,090
+إذاً بدنا نشوف شغلتين في الإنسان الطبيعي LD2 أعلى
+
+294
+00:25:58,090 --> 00:26:05,710
+من LD1 فلو جسمت تركيز LD1 على LD2 حاصل القسمة
+
+295
+00:26:05,710 --> 00:26:13,240
+هيطلع أقل من 1 تمام؟ هذا الإنسان السليم أو حدث عنده
+
+296
+00:26:13,240 --> 00:26:19,080
+مشكلة في القلب ولكن مش ذبحة قلبية لو جسمت LD1 على
+
+297
+00:26:19,080 --> 00:26:25,200
+LD2 برضه هيطلع الـratio أقل من 1 لأن وجدنا أن LD2
+
+298
+00:26:25,200 --> 00:26:32,490
+هتظل أعلى من LD1 لكن إنسان آخر حدثت معه ذبحة قلبية
+
+299
+00:26:32,490 --> 00:26:37,810
+Acute Myocardial Infarction حكالي 1 و 2 بيرتفعوا
+
+300
+00:26:37,810 --> 00:26:44,350
+بس 1 بيرتفع أكثر من 2 وبالتالي لو جسمت LD1 الكبير
+
+301
+00:26:44,350 --> 00:26:50,790
+على LD2 الصغير الـratio بدها تطلع أكبر من 1 إذا
+
+302
+00:26:50,790 --> 00:26:55,630
+الإنسان الطبيعي الـratio بتكون بين الـLD1 والـLD2
+
+303
+00:26:55,630 --> 00:27:01,060
+أقل من 1 والإنسان اللي عنده ذبحة قلبية الـratio ما
+
+304
+00:27:01,060 --> 00:27:08,520
+بين LD1 وLD2 هتطلع  الإنسان طبعاً اللي عنده مشكلة
+
+305
+00:27:08,520 --> 00:27:13,660
+بذبحة قلبية لو جسمت LD1 على LD2 هتطلع أعلى من 1
+
+306
+00:27:13,660 --> 00:27:17,840
+إذا الـratio بتكون أقل من 1 عند الناس الطبيعية وratio
+
+307
+00:27:17,840 --> 00:27:21,720
+أعلى من 1 عند الناس اللي عندها ذبحة قلبية وهذه
+
+308
+00:27:21,720 --> 00:27:26,540
+الظاهرة بيسموها flipped pattern يعني ظاهرة كلمة
+
+309
+00:27:26,540 --> 00:27:31,500
+flip معناها تغير، ظاهرة التغير أن أنا لو إنسان
+
+310
+00:27:31,500 --> 00:27:37,020
+سليم أو عندي مشاكل في عضلة القلب ولكن مش ذبحة قلبية
+
+311
+00:27:37,020 --> 00:27:44,360
+وجسمت التركيز LD1 على LD2 يفترض يطلع حاصل القسمة
+
+312
+00:27:44,360 --> 00:27:49,100
+بينهم الرقم لازم يطلع أقل من واحد لكن لو أنا عندي
+
+313
+00:27:49,100 --> 00:27:57,840
+ذبحة قلبية وروح تجسم التركيز LD1 على LD2 لازم يطلع
+
+314
+00:27:57,840 --> 00:28:02,940
+الـratio ومحصلة التقسيم تطلع أكثر من 1 العدد اللي
+
+315
+00:28:02,940 --> 00:28:08,940
+بدي يطلع من القسمة لازم يكون أكثر من 1 هذه بيسموها
+
+316
+00:28:08,940 --> 00:28:13,460
+flipped pattern يعني مرة أقل من واحد ومرة أكثر من واحد
+
+317
+00:28:13,460 --> 00:28:15,360
+في تغير تمام؟
+
+318
+00:28:18,770 --> 00:28:22,390
+الـ "Say for Enzyme Activity" تقريباً هذه السلايد
+
+319
+00:28:22,390 --> 00:28:27,990
+دي حكيناها بيحكي لي هنا الطرق المستخدمة لقياس نشاط
+
+320
+00:28:27,990 --> 00:28:32,890
+اللاكتات ديهيدروجينيز حكينا طريقة الـkit تعتمد
+
+321
+00:28:32,890 --> 00:28:36,930
+على إنها تقرأ الـabsorbance تقيس الـabsorbance
+
+322
+00:28:36,930 --> 00:28:44,630
+تبع الـNADH عند 340 تمام؟ التفاعل يمكن يتم تجريبه
+
+323
+00:28:44,630 --> 00:28:49,470
+في طريقة إضافية أو عكسية يعني التفاعل بيمشي
+
+324
+00:28:49,470 --> 00:28:53,850
+باتجاهين اللاكتات ديهيدروجينيز ممكن يحول
+
+325
+00:28:53,850 --> 00:28:58,170
+البيروفات إلى لاكتات والـNADH إلى NAD أو العكس يحول
+
+326
+00:28:58,170 --> 00:29:04,280
+اللاكتات إلى بيروفات والـNAD إلى NADH تمام؟ لو كان
+
+327
+00:29:04,280 --> 00:29:10,080
+التفاعل ماشي بشكل forward يعني pyruvate NADH في
+
+328
+00:29:10,080 --> 00:29:14,560
+وجود الإنزيم بعطيني lactate NAD  لازم الـreagent
+
+329
+00:29:14,560 --> 00:29:18,520
+اللي بيكون موجود في الـkit الـpH تبع الـreagent
+
+330
+00:29:18,520 --> 00:29:25,380
+يكون 8.3 إلى 8.9 أما إذا الـreaction ماشي بشكل
+
+331
+00:29:25,380 --> 00:29:30,100
+reverse يعني الإنزيم هيحول اللاكتات إلى pyruvate
+
+332
+00:29:30,100 --> 00:29:36,000
+الـpH تبع الـreagent لازم تكون من 7.1 إلى 7.4
+
+333
+00:29:36,000 --> 00:29:41,460
+تمام؟ مش .. مش هنحفظها لأن الـpH مش كتير بتعنيني
+
+334
+00:29:41,460 --> 00:29:46,080
+تمام؟ لأنها بتيجي مضبوطة من الشركة بس بدنا نفهم أن
+
+335
+00:29:46,080 --> 00:29:51,610
+اللاكتات ديهيدروجينيز هذا الإنزيم بيكون يعني هو
+
+336
+00:29:51,610 --> 00:29:55,750
+بشكل عام أنا الكيت بقيس الـtotal LDH يعني الخمسة
+
+337
+00:29:55,750 --> 00:30:00,050
+isoenzymes مع بعضها كل الخمسة isoenzymes مع بعضها
+
+338
+00:30:00,050 --> 00:30:04,230
+بتكون موجودة في عينة الـpatient لما أنت تدير الـ
+
+339
+00:30:04,230 --> 00:30:09,290
+reagent على عينة الـpatient الـreagent فيه بيروفات
+
+340
+00:30:09,770 --> 00:30:14,530
+هذه الإنزيمات هتحول الـpyruvate إلى lactate وتعمل
+
+341
+00:30:14,530 --> 00:30:19,810
+اختزال، تحول الـNADH إلى NAD أو العكس حكينا ممكن
+
+342
+00:30:19,810 --> 00:30:23,890
+يكون في الـreagent lactate يعني التفاعل يمشي بشكل
+
+343
+00:30:23,890 --> 00:30:29,860
+reversible، تمام؟ هذا بس اللي بدنا نحكي بهذه الـ
+
+344
+00:30:29,860 --> 00:30:36,720
+slide الـreference range للإنزيم من 100 إلى 225
+
+345
+00:30:36,720 --> 00:30:40,920
+هذا تركيز الإنزيم international unit per liter
+
+346
+00:30:40,920 --> 00:30:47,230
+هذا الـnormal range انتبهوا total LDH لـtotal
+
+347
+00:30:47,230 --> 00:30:53,190
+Lactate Dehydrogenase يعني مجموع تركيز الخمس نظائر
+
+348
+00:30:53,190 --> 00:30:57,610
+مع بعضها الـLD1 و LD2 و LD3 و LD4 و LD5 لو جمعت
+
+349
+00:30:57,610 --> 00:31:03,830
+تركيزهم كلهم مع بعض بيكون تركيزهم من 100 إلى 225
+
+350
+00:31:03,830 --> 00:31:07,430
+international unit per liter برضه مش حفظ لأنه من
+
+351
+00:31:07,430 --> 00:31:12,940
+كتالوج الـnormal range مختلف تمام؟ الـmarker
+
+352
+00:31:12,940 --> 00:31:17,460
+الثاني، الـenzyme الثاني اللي بيشيك على وضع عضلة
+
+353
+00:31:17,460 --> 00:31:23,540
+القلب اسمه الـCK اللي هو الكرياتين كيناز أكشن
+
+354
+00:31:23,540 --> 00:31:27,960
+الشغل هذا الـenzyme في الجسم، this enzyme is
+
+355
+00:31:27,960 --> 00:31:31,780
+associated with the regeneration and storage of
+
+356
+00:31:31,780 --> 00:31:36,880
+high energy phosphate ATP وظيفة هذا الـenzyme في
+
+357
+00:31:36,880 --> 00:31:42,140
+الجسم أنه مسؤول عن توليد الطاقة الـregeneration
+
+358
+00:31:42,140 --> 00:31:47,740
+و إنتاج الطاقة and storage وتخزين الطاقة يعني في حال
+
+359
+00:31:47,740 --> 00:31:53,200
+الجسم احتاج لطاقة وبالأخص العضلات في حال احتاجت
+
+360
+00:31:53,200 --> 00:31:57,860
+لطاقة الـCK بيشتغل وبيعمل regeneration بيطلع لها
+
+361
+00:31:57,860 --> 00:32:03,220
+طاقة تمام؟ لكن في حال العضلات كان عندها فائض من الـ
+
+362
+00:32:03,220 --> 00:32:07,720
+ATP فائض من هذه الطاقة هذا الـenzyme مسؤول أنه
+
+363
+00:32:07,720 --> 00:32:15,470
+يعمل storage مسؤول أنه يخزن الطاقة الفائضة تمام؟ It
+
+364
+00:32:15,470 --> 00:32:19,490
+catalyzes the following reversible reaction in the
+
+365
+00:32:19,490 --> 00:32:23,510
+body التفاعل بيمشي باتجاهين إما forward أو
+
+366
+00:32:23,510 --> 00:32:29,350
+reversible حسب حاجة الجسم كيف؟ في حال الجسم كان
+
+367
+00:32:29,350 --> 00:32:32,630
+عنده فائض وخاصة في العضلات يعني هذا الـreaction
+
+368
+00:32:32,630 --> 00:32:37,920
+أكثر شيء بيصير في العضلات خاصة لو كان الجسم يعني لو
+
+369
+00:32:37,920 --> 00:32:43,760
+بدنا نمشي بشكل forward كرياتين زائد ATP في وجود
+
+370
+00:32:43,760 --> 00:32:50,300
+الإنزيم الـCK يعني مادة الكرياتين مرتبطة في الـATP
+
+371
+00:32:50,300 --> 00:32:54,360
+أنا لما بمشي بشكل forward من التفاعل معناه أنا
+
+372
+00:32:54,360 --> 00:32:59,640
+عندي فائض من الـATP الـATP هي الطاقة أنا عندي فائض
+
+373
+00:32:59,640 --> 00:33:04,870
+فالجسم بيعمل storage بيخزن هذه الطاقة فالـcreatine
+
+374
+00:33:04,870 --> 00:33:12,170
+بي مرتبط مع الـATP الفائض في وجود أنزيم الـCK هيتم
+
+375
+00:33:12,170 --> 00:33:17,710
+فقد فوسفات جروب من الـATP وتحويلها إلى creatine
+
+376
+00:33:17,710 --> 00:33:23,670
+فبيعطيني مركب اسمه creatine phosphate زائد ADP إذاً هيك
+
+377
+00:33:23,670 --> 00:33:27,570
+الجسم خزن الطاقة يعني لو أنا بدي أمشي باتجاه
+
+378
+00:33:27,570 --> 00:33:32,750
+العكسي من التفاعل معناه أنا هيك بخزن طاقة okay في
+
+379
+00:33:32,750 --> 00:33:37,030
+حال العضلات احتاجت إلى طاقة يعني الجسم بدي يعمل
+
+380
+00:33:37,030 --> 00:33:42,560
+regeneration بدي يولّد الطاقة تمام؟ هنمشي بشكل
+
+381
+00:33:42,560 --> 00:33:48,500
+reversible creatine phosphate هذه المادة هيتم فقد
+
+382
+00:33:48,500 --> 00:33:54,340
+منها فوسفات group وتروح إلى الـADP وبالتالي
+
+383
+00:33:54,340 --> 00:33:59,320
+الـADP زائد فوسفات group هيعطيني ATP
+
+384
+00:33:59,320 --> 00:34:03,900
+والكرياتين فوسفات لما نزع منها فوسفات group
+
+385
+00:34:03,900 --> 00:34:10,290
+هتظل كرياتين يعني لما أمشي بشكل عكسي ADP زائد
+
+386
+00:34:10,290 --> 00:34:15,250
+كرياتين فوسفات في وجود الـCK بعطيني ATP وكرياتين
+
+387
+00:34:15,250 --> 00:34:20,510
+إذن هيك احنا عملنا regeneration للطاقة وطلعنا ATP
+
+388
+00:34:20,510 --> 00:34:25,890
+من التفاعل طبعاً يعني حفظ ولا مش حفظ لازم نفهم أن
+
+389
+00:34:25,890 --> 00:34:30,550
+الـCK من الإنزيمات المهمة في الجسم مسؤولة عن إنتاج
+
+390
+00:34:30,550 --> 00:34:36,950
+وتخزين الطاقة الفائضة، تمام؟ هنجي زي ما حك
+
+445
+00:39:39,010 --> 00:39:42,910
+Diagnostic
+
+446
+00:39:42,910 --> 00:39:47,870
+significance أهمية فحص الـCK والـIsoenzyme. The
+
+447
+00:39:47,870 --> 00:39:51,890
+value of CK-Isoenzyme separation can be found
+
+448
+00:39:51,890 --> 00:39:55,870
+principally in detection of myocardial damage. يعني
+
+449
+00:39:55,870 --> 00:40:01,950
+لما أنا أشتغل، يعني أفحص تركيز، وأقيس تركيز CK1 و
+
+450
+00:40:01,950 --> 00:40:07,970
+CK2 و CK3 بشكل منفصل، أنا هيك بقدر أحكي إنه هل
+
+451
+00:40:07,970 --> 00:40:13,110
+المريض عنده دبحــة قلبية ولا لا. كيف؟ إنه CK2 لو طلع
+
+452
+00:40:13,660 --> 00:40:17,700
+أعلى من الوضع الطبيعي، معناه أكيد في عنده ضبحة
+
+453
+00:40:17,700 --> 00:40:22,200
+قلبية، صح ولا لأ؟ لأن CK2 هو اللي متركز في عضلة
+
+454
+00:40:22,200 --> 00:40:27,340
+القلب. فلو صار دَمج فيها، فهيطلع CK2 من عضلة القلب للـ
+
+455
+00:40:27,340 --> 00:40:31,470
+Plasma، الدم. إذًا من خلال الـ Separation للـ
+
+456
+00:40:31,470 --> 00:40:36,530
+Isoenzyme بتقنية الـ Electrophoresis اللي بتقيسلي
+
+457
+00:40:36,530 --> 00:40:41,530
+كل إنزايم على حدة، أنا بقدر أكشف إنه هل هذا الشخص
+
+458
+00:40:41,530 --> 00:40:46,630
+عنده Acute Myocardial Infarction or not، تمام؟
+
+459
+00:40:47,750 --> 00:40:52,370
+Cardiac Tissue Contains Significant Quantities Of
+
+460
+00:40:52,370 --> 00:40:58,490
+CKMB. Approximately 20% من كل الـ CKMB بيحكيلي عضلة
+
+461
+00:40:58,490 --> 00:41:05,510
+القلب تحتوي بشكل أساسي على كمية كبيرة من الـ
+
+462
+00:41:05,510 --> 00:41:11,210
+Isoenzyme CK2. من الـ «CKMB»، الإسم الآخر له. اتفقنا
+
+463
+00:41:11,210 --> 00:41:18,370
+إنّه 20% من هذا الـ Isoenzyme موجود بعضلة القلب. إذن
+
+464
+00:41:18,370 --> 00:41:24,530
+20% من الـ «CKMB» متركزة في عضلة القلب، فهو نوعا ما
+
+465
+00:41:24,530 --> 00:41:30,910
+متخصص لعضلة القلب. لكن سي كي واحد وتلاتة، لأ، مش
+
+466
+00:41:30,910 --> 00:41:35,970
+موجودين بعضلة القلب، موجودين ولكن بتركيز قليل جداً
+
+467
+00:41:35,970 --> 00:41:41,970
+واحد بالمية، تمام؟ فعشان هيك، عشان أنا أتأكد إنه
+
+468
+00:41:41,970 --> 00:41:46,950
+هذا الشخص عنده دَبحــة قلبية، إيش بعمل؟ بروح أعمله
+
+469
+00:41:46,950 --> 00:41:52,610
+فحص الـ Total CK. بجيب كيت الـ Total CK اللي بحسبلي
+
+470
+00:41:52,610 --> 00:41:57,590
+CK1 زائد CK2 زائد CK3، وبيعطيني تركيزهم التلاتة
+
+471
+00:41:57,590 --> 00:42:03,630
+مع بعض، مجموع التركيز، تمام؟ بجمع التلاتة وبيعطيني
+
+472
+00:42:03,630 --> 00:42:07,990
+تركيزهم التلاتة مع بعض، تمام؟ إذا بيجيني مريض
+
+473
+00:42:07,990 --> 00:42:14,290
+بقيسله Total CK وبسجل النتيجة، وبرضه بروح أقيسله
+
+474
+00:42:14,290 --> 00:42:21,030
+تركيز الـ CK2، اللي اسمه CKMB. هذا الـ enzyme، هذا
+
+475
+00:42:21,030 --> 00:42:24,930
+النظير المتخصص بعضلة القلب، برضه بقيسله تركيزه
+
+476
+00:42:24,930 --> 00:42:28,670
+اتفقنا. مش بتقنيات يعني عادي، ممكن أعمل
+
+477
+00:42:28,670 --> 00:42:33,250
+Electrophoresis، ولكن بتكلف.  حكينا لكم إنّه موجود في
+
+478
+00:42:33,250 --> 00:42:38,510
+الجامعة، كيت بقيس الـ Total CK، وكيت بقيس كمان
+
+479
+00:42:38,510 --> 00:42:43,790
+النظير، الـ CK2، تركيز فقط الـ CK2. فأنا بفحصله
+
+480
+00:42:43,790 --> 00:42:49,030
+الفحصين. بعمله Total CK وبسجل النتيجة، وبعمله الـ
+
+481
+00:42:49,030 --> 00:42:55,270
+CK2 وبسجل نتيجته. وبروح أطبّق قانون، القانون إيش
+
+482
+00:42:55,270 --> 00:43:01,970
+بيحكيلي؟  تركيز الـ CK2 على الـ Total CK.
+
+483
+00:43:01,970 --> 00:43:06,310
+إذا بدك تعرفي إن الشخص عنده acute myocardial
+
+484
+00:43:06,310 --> 00:43:10,890
+infarction ولا لا، اعملي فحصين الـ Total CK والـ
+
+485
+00:43:10,890 --> 00:43:19,150
+CK2. وروح اجمعي تركيز الـ CK2، تركيز النظير على الـ
+
+486
+00:43:19,150 --> 00:43:28,130
+Total CK. لو طلعت الـ ratio أقل من 6%، إذًا هذا إنسان
+
+487
+00:43:28,130 --> 00:43:32,670
+سليم، طبعًا. أنا أحكي لك 6%، إنتِ رح تجمعي تركيز
+
+488
+00:43:32,670 --> 00:43:41,790
+الـCK2 على تركيز الـ Total CK، وضرب بـ 100%، تمام؟ لو
+
+489
+00:43:41,790 --> 00:43:47,740
+طلعت النتيجة أقل من 6%، هذا إنسان سليم. لو طلعت الـ
+
+490
+00:43:47,740 --> 00:43:52,560
+ratio أعلى من 6%، معناه أكيد في عنده Acute
+
+491
+00:43:52,560 --> 00:43:59,700
+Myocardial Infarction. نقرأ Increased CK MB. يعني لو
+
+492
+00:43:59,700 --> 00:44:07,540
+طلعت الـ CK MB أعلى بـ 6% من الـ Total CK activity
+
+493
+00:44:07,540 --> 00:44:11,440
+is a strong indication للـ Acute Myocardial
+
+494
+00:44:11,440 --> 00:44:16,140
+Infarction.  جزء بهذه الجملة. لو إنتِ جمعتي تركيز
+
+495
+00:44:16,140 --> 00:44:21,340
+الـCK2، أو الاسم الآخر له الـCKMB، جمعتي تركيز
+
+496
+00:44:21,340 --> 00:44:27,780
+النظير على تركيز الـTotal CK، وضربتي بـ100%، طلعت
+
+497
+00:44:27,780 --> 00:44:35,500
+القيمة أقل من أو يساوي 6%، إذًا هذا إنسان سليم. أعلى
+
+498
+00:44:35,500 --> 00:44:41,840
+من 6%، إذًا بيكون عنده Acute Myocardial Infarction.
+
+499
+00:44:41,840 --> 00:44:47,690
+تمام؟ Post Acute Myocardial Infarction. الـ «CKMB»
+
+500
+00:44:47,690 --> 00:44:52,050
+يعني بعد ما يصير عندي دَبحــة قلبية، إيش بيصير في هذا
+
+501
+00:44:52,050 --> 00:44:55,870
+الـ enzyme؟ أنا بعرف إنه هيطلع من عضلة القلب إلى
+
+502
+00:44:55,870 --> 00:45:02,950
+الدم، صح ولا لا؟ الـ «CKMB» تزيد 4 إلى 8 ساعات بعد
+
+503
+00:45:02,950 --> 00:45:05,970
+الـ Acute Myocardial Infarction. يعني هالجيت لما
+
+504
+00:45:05,970 --> 00:45:12,530
+تصاب بدَبحــة قلبية، بعد الإصابة بـ 4 إلى 8 ساعات، بدأ
+
+505
+00:45:12,740 --> 00:45:18,280
+الـ CKMB بالارتفاع، تمام؟ بيبدأ يطلع من عضلة القلب
+
+506
+00:45:18,280 --> 00:45:23,640
+وبيبدأ يرتفع تركيزه في بلازما الدم، وبيصل إلى الـ
+
+507
+00:45:23,640 --> 00:45:27,700
+peaks. كلمة peaks يعني بيصل لأعلى تركيز في بلازما
+
+508
+00:45:27,700 --> 00:45:36,860
+الدم خلال 12 لـ 24 ساعة بعد الإصابة، تمام؟ وبيضل
+
+509
+00:45:36,860 --> 00:45:44,160
+عالي في الجسم تقريباً من يومين لثلاثة أيام. بعد يومين
+
+510
+00:45:44,160 --> 00:45:48,360
+لثلاثة أيام، بيبدأ يرجع طبيعي. يعني هو بيضل عالي في
+
+511
+00:45:48,360 --> 00:45:54,460
+الجسم، وبعد يومين لثلاثة أيام من الإصابة بيبدأ يقل
+
+512
+00:45:54,460 --> 00:46:01,510
+ويرجع تركيزه للوضع الطبيعي، تمام؟ إذًا هو نوعاً ما
+
+513
+00:46:01,510 --> 00:46:07,050
+بنقدر نحكي عنه هذا الـ Isoenzyme متخصص لعضلة القلب
+
+514
+00:46:07,050 --> 00:46:11,070
+ومن خلاله أنا بتابع المريض، هل في عنده acute
+
+515
+00:46:11,070 --> 00:46:14,750
+myocardial infarction or not، تمام؟
+
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/GY2MTVi93So_raw.json b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/GY2MTVi93So_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..58e54e9163bfda591af9b2edf672f0c127a70ac7
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+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/GY2MTVi93So_raw.json
@@ -0,0 +1 @@
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0.990234375}, {"start": 228.7, "end": 229.2, "word": " جدًا", "probability": 0.949951171875}, {"start": 229.2, "end": 229.82, "word": " لكن", "probability": 0.93994140625}, {"start": 229.82, "end": 230.4, "word": " مكانه", "probability": 0.99169921875}, {"start": 230.4, "end": 230.88, "word": " الأصلي", "probability": 0.869140625}, {"start": 230.88, "end": 231.12, "word": " في", "probability": 0.99609375}, {"start": 231.12, "end": 231.58, "word": " عضلة", "probability": 0.99267578125}, {"start": 231.58, "end": 232.32, "word": " القلب", "probability": 0.996826171875}, {"start": 232.32, "end": 232.9, "word": " الـ", "probability": 0.927001953125}, {"start": 232.9, "end": 233.64, "word": " Aspartate", "probability": 0.8816731770833334}, {"start": 233.64, "end": 235.08, "word": " Transaminase", "probability": 0.8025716145833334}], "temperature": 1.0}, {"id": 12, "seek": 26422, "start": 235.2, "end": 264.22, "text": "الإنزايم التاني الـ Lactate Dehydrogenase أو الإختصار تبعه الـ LDH أو في ناس بتحكي LD وخلاص، تمام؟ سواء كتبنا LD أو LDH هو الـ Lactate Dehydrogenase هذا الإنزايم في منه five isoenzymes في منه خمس نظائر وكل نظير منه بيكون موجود بعضو معين في الجسم، تمام؟", "tokens": [6027, 28814, 1863, 11622, 995, 32640, 16712, 7649, 1829, 2423, 39184, 441, 578, 473, 1346, 21591, 7747, 651, 34051, 33688, 46456, 9381, 9640, 6055, 3555, 3615, 3224, 2423, 39184, 33936, 39, 34051, 8978, 8717, 32277, 39894, 5016, 4117, 1829, 33936, 4032, 9778, 1211, 33546, 12399, 46811, 10943, 22807, 8608, 2407, 16606, 9122, 2655, 3555, 8315, 33936, 34051, 33936, 39, 31439, 2423, 39184, 441, 578, 473, 1346, 21591, 7747, 651, 23758, 33688, 1863, 11622, 995, 32640, 8978, 9154, 3224, 1732, 307, 78, 268, 1229, 5814, 8978, 9154, 3224, 16490, 2304, 3794, 8717, 19913, 16373, 2288, 4032, 28820, 8717, 19913, 13546, 9154, 3224, 4724, 1829, 30544, 3714, 29245, 23328, 45030, 11242, 2407, 20449, 9957, 8978, 25724, 38251, 12399, 46811, 10943, 22807], "avg_logprob": -0.14335937661429246, "compression_ratio": 1.6458333333333333, "no_speech_prob": 7.748603820800781e-07, "words": [{"start": 235.2, "end": 236.2, "word": "الإنزايم", "probability": 0.8531901041666666}, {"start": 236.2, "end": 236.82, "word": " التاني", "probability": 0.9195963541666666}, {"start": 236.82, "end": 237.3, "word": " الـ", "probability": 0.615234375}, {"start": 237.3, "end": 237.9, "word": " Lactate", "probability": 0.84765625}, {"start": 237.9, "end": 239.3, "word": " Dehydrogenase", "probability": 0.913330078125}, {"start": 239.3, "end": 239.7, "word": " أو", "probability": 0.8369140625}, {"start": 239.7, "end": 240.5, "word": " الإختصار", "probability": 0.9422607421875}, {"start": 240.5, "end": 241.4, "word": " تبعه", "probability": 0.9102783203125}, {"start": 241.4, "end": 241.78, "word": " الـ", "probability": 0.87744140625}, {"start": 241.78, "end": 242.72, "word": " LDH", "probability": 0.823974609375}, {"start": 242.72, "end": 243.02, "word": " أو", "probability": 0.92822265625}, {"start": 243.02, "end": 243.2, "word": " في", "probability": 0.92236328125}, {"start": 243.2, "end": 243.44, "word": " ناس", "probability": 0.96630859375}, {"start": 243.44, "end": 243.94, "word": " بتحكي", "probability": 0.962890625}, {"start": 243.94, "end": 244.32, "word": " LD", "probability": 0.8828125}, {"start": 244.32, "end": 245.18, "word": " وخلاص،", "probability": 0.81650390625}, {"start": 245.18, "end": 245.68, "word": " تمام؟", "probability": 0.8816731770833334}, {"start": 245.68, "end": 246.24, "word": " سواء", "probability": 0.9775390625}, {"start": 246.24, "end": 246.76, "word": " كتبنا", "probability": 0.9884033203125}, {"start": 246.76, "end": 247.14, "word": " LD", "probability": 0.9521484375}, {"start": 247.14, "end": 247.68, "word": " أو", "probability": 0.91796875}, {"start": 247.68, "end": 248.58, "word": " LDH", "probability": 0.95166015625}, {"start": 248.58, "end": 248.96, "word": " هو", "probability": 0.8603515625}, {"start": 248.96, "end": 249.72, "word": " الـ", "probability": 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قياسه من خلال قياس ومتابعة الـ «absorbance» عند 340 لأن خلال التفاعل", "tokens": [2407, 6027, 20292, 39894, 38436, 12984, 8717, 8592, 41193, 2423, 39184, 4657, 28814, 1863, 11622, 995, 9957, 5933, 6055, 34268, 2304, 3215, 15844, 12174, 25528, 3794, 2423, 39184, 4657, 17243, 30907, 719, 5933, 5296, 29973, 4117, 3555, 2423, 8315, 3215, 12174, 3215, 8592, 43242, 805, 5254, 37495, 22653, 8978, 9154, 9566, 28671, 2423, 39184, 4657, 52, 53, 5933, 2423, 39184, 4657, 1479, 578, 4253, 307, 12690, 5933, 37495, 22653, 6055, 31747, 1829, 11622, 34051, 8717, 8592, 41193, 2423, 39184, 4657, 28814, 1863, 11622, 995, 9957, 5933, 4724, 39237, 12174, 25528, 3794, 3224, 9154, 16490, 1211, 6027, 12174, 25528, 3794, 4032, 2304, 2655, 16758, 27884, 2423, 39184, 4657, 17243, 30907, 719, 5933, 43242, 805, 5254, 5296, 33456, 16490, 1211, 6027, 16712, 5172, 995, 30241], "avg_logprob": -0.16494456173912173, "compression_ratio": 1.7747747747747749, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 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"text": "هدولة مع بعض اسمهم Total LD هم كل اللاكتات دي Hydrogenase الـ Total يعني الكتات، الكت اللي فعليا موجودة عندنا بالجامعة بقيس الـ Total LDH بقيس LD1 زائد، LD2 زائد، LD3 زائد، LD4 زائد، LD5 بقيس كل الـ Isoenzyme اللي موجودة في الدم، تمام؟", "tokens": [3224, 3215, 12610, 3660, 20449, 45030, 11242, 24525, 2304, 16095, 23170, 33936, 8032, 2304, 28242, 13672, 995, 4117, 2655, 9307, 11778, 1829, 24231, 7747, 651, 2423, 39184, 23170, 37495, 22653, 33251, 2655, 9307, 12399, 33251, 2655, 13672, 1829, 6156, 3615, 20292, 995, 3714, 29245, 23328, 3660, 43242, 8315, 20666, 7435, 10943, 27884, 4724, 38436, 3794, 2423, 39184, 23170, 33936, 39, 4724, 38436, 3794, 33936, 16, 30767, 16373, 3215, 12399, 33936, 17, 30767, 16373, 3215, 12399, 33936, 18, 30767, 16373, 3215, 12399, 33936, 19, 30767, 16373, 3215, 12399, 33936, 20, 4724, 38436, 3794, 28242, 2423, 39184, 286, 539, 268, 1229, 1398, 13672, 1829, 3714, 29245, 23328, 3660, 8978, 32748, 2304, 12399, 46811, 10943, 22807], "avg_logprob": 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{"start": 687.94, "end": 688.24, "word": " عالي", "probability": 0.9853515625}, {"start": 688.24, "end": 689.0, "word": " كتير،", "probability": 0.9111328125}, {"start": 689.0, "end": 689.2, "word": " هذا", "probability": 0.8408203125}, {"start": 689.2, "end": 689.68, "word": " بيعطيك", "probability": 0.94619140625}, {"start": 689.68, "end": 690.2, "word": " indication", "probability": 0.5634765625}, {"start": 690.2, "end": 690.76, "word": " لشو؟", "probability": 0.957275390625}], "temperature": 1.0}, {"id": 33, "seek": 71272, "start": 691.3, "end": 712.72, "text": "بيعطيني indication فقط إن هذا المريض عنده damage في عضو معين، عنده خراب في عضو معين، بس إيش هو العضو اللي فيه المشكلة، ما بتقدر تعرفه، ليش؟ لأنه بتكون تعرف إن الخمسة isoenzyme، الخمس نظائر اللي بتكون موجودة في الدم", "tokens": [21292, 3615, 9566, 1829, 22653, 18877, 6156, 47432, 36145, 23758, 9673, 16572, 11242, 43242, 3224, 4344, 8978, 6225, 11242, 2407, 20449, 9957, 12399, 43242, 3224, 16490, 2288, 16758, 8978, 6225, 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"end": 695.0, "word": " المريض", "probability": 0.9739583333333334}, {"start": 695.0, "end": 695.92, "word": " عنده", "probability": 0.97412109375}, {"start": 695.92, "end": 696.9, "word": " damage", "probability": 0.720703125}, {"start": 696.9, "end": 697.26, "word": " في", "probability": 0.96240234375}, {"start": 697.26, "end": 697.48, "word": " عضو", "probability": 0.8336588541666666}, {"start": 697.48, "end": 698.14, "word": " معين،", "probability": 0.7985026041666666}, {"start": 698.14, "end": 698.6, "word": " عنده", "probability": 0.986572265625}, {"start": 698.6, "end": 699.22, "word": " خراب", "probability": 0.9869791666666666}, {"start": 699.22, "end": 699.48, "word": " في", "probability": 0.9765625}, {"start": 699.48, "end": 699.72, "word": " عضو", "probability": 0.99658203125}, {"start": 699.72, "end": 700.68, "word": " معين،", "probability": 0.9332682291666666}, {"start": 700.68, "end": 700.92, "word": " بس", "probability": 0.975341796875}, {"start": 700.92, "end": 701.2, "word": " إيش", "probability": 0.9176432291666666}, {"start": 701.2, "end": 701.48, "word": " هو", "probability": 0.9765625}, {"start": 701.48, "end": 701.98, "word": " العضو", "probability": 0.9912109375}, {"start": 701.98, "end": 702.34, "word": " اللي", "probability": 0.90234375}, {"start": 702.34, "end": 702.6, "word": " فيه", "probability": 0.983154296875}, {"start": 702.6, "end": 703.44, "word": " المشكلة،", "probability": 0.91513671875}, {"start": 703.44, "end": 703.62, "word": " ما", "probability": 0.67529296875}, {"start": 703.62, "end": 704.22, "word": " بتقدر", "probability": 0.709716796875}, {"start": 704.22, "end": 705.34, "word": " تعرفه،", "probability": 0.749267578125}, {"start": 705.34, "end": 706.2, "word": " ليش؟", "probability": 0.95556640625}, {"start": 706.2, "end": 706.58, "word": " لأنه", "probability": 0.89794921875}, {"start": 706.58, "end": 706.88, "word": " بتكون", "probability": 0.7138671875}, {"start": 706.88, "end": 707.24, "word": " تعرف", "probability": 0.94384765625}, {"start": 707.24, "end": 707.56, "word": " إن", "probability": 0.73681640625}, {"start": 707.56, "end": 708.8, "word": " الخمسة", "probability": 0.9228515625}, {"start": 708.8, "end": 709.82, "word": " isoenzyme،", "probability": 0.6877848307291666}, {"start": 709.82, "end": 710.24, "word": " الخمس", "probability": 0.9886067708333334}, {"start": 710.24, "end": 710.94, "word": " نظائر", "probability": 0.932373046875}, {"start": 710.94, "end": 711.26, "word": " اللي", "probability": 0.94091796875}, {"start": 711.26, "end": 711.68, "word": " بتكون", "probability": 0.948974609375}, {"start": 711.68, "end": 712.26, "word": " موجودة", "probability": 0.9866943359375}, {"start": 712.26, "end": 712.4, "word": " في", "probability": 0.98876953125}, {"start": 712.4, "end": 712.72, "word": " الدم", "probability": 0.989013671875}], "temperature": 1.0}, {"id": 34, "seek": 73835, "start": 713.19, "end": 738.35, "text": "موجودة في low concentration يعني معظم الإنزيمات بتكون موجودة في الدم ولكن بتركيز قليل هذا الإنسان الطبيعي لكن لو إجالي شخص اعملتله total LD يعني فحصتله كل الخمسة ISO enzyme مع بعض وسجلت نتجتها وطلعت عالية كتير معناه الكلام إذا عالية الإنزيمات كتير معناه في عنده damage", "tokens": [2304, 29245, 23328, 3660, 8978, 2295, 9856, 37495, 22653, 20449, 19913, 2304, 33688, 1863, 11622, 32640, 9307, 39894, 30544, 3714, 29245, 23328, 3660, 8978, 32748, 2304, 35525, 19452, 39894, 31747, 1829, 11622, 12174, 20292, 1211, 23758, 33688, 1863, 3794, 7649, 41950, 21292, 3615, 1829, 44381, 45164, 11933, 7435, 6027, 1829, 13412, 9778, 9381, 1975, 25957, 1211, 2655, 43761, 3217, 33936, 37495, 22653, 6156, 5016, 9381, 2655, 43761, 28242, 33962, 2304, 3794, 3660, 25042, 24521, 20449, 45030, 11242, 46952, 7435, 1211, 2655, 8717, 2655, 7435, 2655, 11296, 4032, 9566, 1211, 34268, 6225, 6027, 10632, 9122, 2655, 13546, 20449, 8315, 3224, 2423, 28820, 10943, 11933, 15730, 6225, 6027, 10632, 33688, 1863, 11622, 32640, 9307, 9122, 2655, 13546, 20449, 8315, 3224, 8978, 43242, 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total", "probability": 0.471923828125}, {"start": 725.89, "end": 726.57, "word": " LD", "probability": 0.93408203125}, {"start": 726.57, "end": 727.15, "word": " يعني", "probability": 0.93310546875}, {"start": 727.15, "end": 727.81, "word": " فحصتله", "probability": 0.80205078125}, {"start": 727.81, "end": 728.13, "word": " كل", "probability": 0.98876953125}, {"start": 728.13, "end": 728.67, "word": " الخمسة", "probability": 0.9542236328125}, {"start": 728.67, "end": 728.89, "word": " ISO", "probability": 0.31005859375}, {"start": 728.89, "end": 729.41, "word": " enzyme", "probability": 0.3525390625}, {"start": 729.41, "end": 729.67, "word": " مع", "probability": 0.982421875}, {"start": 729.67, "end": 730.01, "word": " بعض", "probability": 0.959716796875}, {"start": 730.01, "end": 730.65, "word": " وسجلت", "probability": 0.820556640625}, {"start": 730.65, "end": 731.29, "word": " نتجتها", "probability": 0.91796875}, {"start": 731.29, "end": 732.19, "word": " وطلعت", "probability": 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"probability": 0.82275390625}], "temperature": 1.0}, {"id": 35, "seek": 76694, "start": 738.94, "end": 766.94, "text": "لكن ما بعرف أي عضو حدث فيه الدمش تمام؟ هي مشكلة فحص الـ Total LD عشان هيك بيلجأوا لفحص الـ Electrophoresis بياخدوا سيرام وهذا السيرام بيفصله العينة أو بيفصله الـ Isoenzyme بعطيك تركيز الـ LD1 والـ LD2 والـ LD3 والـ LD4 والـ LD5 كل واحد تركيزه على حدا", "tokens": [1211, 19452, 19446, 45030, 28480, 36632, 6225, 11242, 2407, 11331, 3215, 12984, 8978, 3224, 32748, 2304, 8592, 46811, 10943, 22807, 39896, 37893, 28820, 3660, 6156, 5016, 9381, 2423, 39184, 23170, 33936, 6225, 8592, 7649, 39896, 4117, 4724, 26895, 7435, 10721, 14407, 5296, 5172, 5016, 9381, 2423, 39184, 12575, 11741, 2706, 271, 4724, 1829, 47283, 3215, 14407, 8608, 13546, 10943, 37037, 15730, 21136, 13546, 10943, 4724, 33911, 36520, 3224, 18863, 9957, 3660, 34051, 4724, 33911, 36520, 3224, 2423, 39184, 286, 539, 268, 1229, 1398, 4724, 3615, 9566, 1829, 4117, 6055, 31747, 1829, 11622, 2423, 39184, 33936, 16, 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857.77, "word": " الدي", "probability": 0.884765625}, {"start": 857.77, "end": 858.39, "word": " يعني", "probability": 0.931640625}, {"start": 858.39, "end": 858.93, "word": " بجمع", "probability": 0.916015625}, {"start": 858.93, "end": 859.85, "word": " تركيزهم", "probability": 0.99375}, {"start": 859.85, "end": 860.65, "word": " وبعطيني", "probability": 0.853466796875}, {"start": 860.65, "end": 861.33, "word": " تركيز", "probability": 0.9937744140625}, {"start": 861.33, "end": 862.09, "word": " نهائي", "probability": 0.9844970703125}, {"start": 862.09, "end": 862.83, "word": " تمام", "probability": 0.95556640625}], "temperature": 1.0}, {"id": 40, "seek": 88037, "start": 863.91, "end": 880.37, "text": "عشان هيك حكيتلكم إن فحص الـ Total LD مش كتير مفيد فالإفادة أكتر إن كل إنزايم أعرف تركيزه على حدا يعني أعرف تركيز LD1 لحاله وLD2 لحاله وLD3 لحاله", "tokens": [3615, 8592, 7649, 39896, 4117, 11331, 4117, 36081, 23275, 2304, 36145, 6156, 5016, 9381, 2423, 39184, 23170, 33936, 37893, 9122, 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{"start": 865.97, "end": 866.29, "word": " Total", "probability": 0.6591796875}, {"start": 866.29, "end": 866.83, "word": " LD", "probability": 0.5869140625}, {"start": 866.83, "end": 867.47, "word": " مش", "probability": 0.52294921875}, {"start": 867.47, "end": 868.01, "word": " كتير", "probability": 0.953125}, {"start": 868.01, "end": 868.91, "word": " مفيد", "probability": 0.9588216145833334}, {"start": 868.91, "end": 870.71, "word": " فالإفادة", "probability": 0.8876953125}, {"start": 870.71, "end": 871.23, "word": " أكتر", "probability": 0.9892578125}, {"start": 871.23, "end": 871.85, "word": " إن", "probability": 0.6318359375}, {"start": 871.85, "end": 872.29, "word": " كل", "probability": 0.66650390625}, {"start": 872.29, "end": 872.99, "word": " إنزايم", "probability": 0.776123046875}, {"start": 872.99, "end": 873.49, "word": " أعرف", "probability": 0.9944661458333334}, {"start": 873.49, "end": 874.07, "word": " تركيزه", "probability": 0.99140625}, {"start": 874.07, "end": 874.25, "word": " على", "probability": 0.9375}, {"start": 874.25, "end": 874.63, "word": " حدا", "probability": 0.7314453125}, {"start": 874.63, "end": 874.93, "word": " يعني", "probability": 0.775634765625}, {"start": 874.93, "end": 875.25, "word": " أعرف", "probability": 0.984375}, {"start": 875.25, "end": 875.67, "word": " تركيز", "probability": 0.9910888671875}, {"start": 875.67, "end": 876.39, "word": " LD1", "probability": 0.624267578125}, {"start": 876.39, "end": 877.25, "word": " لحاله", "probability": 0.9735107421875}, {"start": 877.25, "end": 878.21, "word": " وLD2", "probability": 0.7830403645833334}, {"start": 878.21, "end": 878.87, "word": " لحاله", "probability": 0.9932861328125}, {"start": 878.87, "end": 879.65, "word": " وLD3", "probability": 0.7460123697916666}, {"start": 879.65, "end": 880.37, "word": " لحاله", "probability": 0.99560546875}], "temperature": 1.0}, {"id": 41, "seek": 90230, "start": 880.6, "end": 902.3, "text": "هذا بيعطيني فايدة أكتر من فحص الـ Total LD من فحص مجموعهم مع بعض تمام؟ كيف بعرف تركيز كل واحد على حدة من خلال الـ Electrophoresis الفصل الجاي هنعرف انجيس الـ LD1 والـ LD2 والـ LD3 كل واحد على حدة بطريقة الـ Electrophoresis", "tokens": [3224, 15730, 4724, 40228, 9566, 1829, 22653, 6156, 995, 25708, 3660, 5551, 4117, 2655, 2288, 9154, 6156, 5016, 9381, 2423, 39184, 23170, 33936, 9154, 6156, 5016, 9381, 3714, 7435, 2304, 45367, 16095, 20449, 45030, 11242, 46811, 10943, 22807, 9122, 33911, 45030, 28480, 6055, 31747, 1829, 11622, 28242, 36764, 24401, 15844, 11331, 41891, 9154, 16490, 1211, 6027, 2423, 39184, 12575, 11741, 2706, 271, 27188, 36520, 25724, 47302, 8032, 1863, 3615, 28480, 16472, 7435, 1829, 3794, 2423, 39184, 33936, 16, 16070, 39184, 33936, 17, 16070, 39184, 33936, 18, 28242, 36764, 24401, 15844, 11331, 41891, 4724, 9566, 16572, 28671, 2423, 39184, 12575, 11741, 2706, 271], "avg_logprob": -0.13076455992402383, "compression_ratio": 1.6952380952380952, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 880.6, 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" مع", "probability": 0.99609375}, {"start": 885.54, "end": 885.9, "word": " بعض", "probability": 0.987548828125}, {"start": 885.9, "end": 886.84, "word": " تمام؟", "probability": 0.7501627604166666}, {"start": 886.84, "end": 887.3, "word": " كيف", "probability": 0.96630859375}, {"start": 887.3, "end": 887.74, "word": " بعرف", "probability": 0.953125}, {"start": 887.74, "end": 888.38, "word": " تركيز", "probability": 0.993408203125}, {"start": 888.38, "end": 888.66, "word": " كل", "probability": 0.98095703125}, {"start": 888.66, "end": 889.12, "word": " واحد", "probability": 0.99658203125}, {"start": 889.12, "end": 889.42, "word": " على", "probability": 0.82080078125}, {"start": 889.42, "end": 889.84, "word": " حدة", "probability": 0.6707763671875}, {"start": 889.84, "end": 890.36, "word": " من", "probability": 0.97998046875}, {"start": 890.36, "end": 890.94, "word": " خلال", "probability": 0.9959309895833334}, {"start": 890.94, "end": 891.54, "word": " الـ", "probability": 0.961181640625}, {"start": 891.54, "end": 892.48, "word": " Electrophoresis", "probability": 0.902587890625}, {"start": 892.48, "end": 893.18, "word": " الفصل", "probability": 0.757080078125}, {"start": 893.18, "end": 893.74, "word": " الجاي", "probability": 0.783935546875}, {"start": 893.74, "end": 894.58, "word": " هنعرف", "probability": 0.875244140625}, {"start": 894.58, "end": 895.36, "word": " انجيس", "probability": 0.7095947265625}, {"start": 895.36, "end": 895.56, "word": " الـ", "probability": 0.948974609375}, {"start": 895.56, "end": 896.18, "word": " LD1", "probability": 0.777099609375}, {"start": 896.18, "end": 896.56, "word": " والـ", "probability": 0.5211181640625}, {"start": 896.56, "end": 897.0, "word": " LD2", "probability": 0.918701171875}, {"start": 897.0, "end": 897.24, "word": " والـ", "probability": 0.882568359375}, {"start": 897.24, "end": 897.66, "word": " LD3", "probability": 0.9541015625}, {"start": 897.66, "end": 898.06, "word": " كل", "probability": 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الاسم الأخر لـ Isoenzyme", "tokens": [1211, 2407, 11331, 4117, 36081, 23275, 2304, 20666, 10943, 2655, 5016, 7649, 2423, 39184, 413, 16, 34051, 2423, 39184, 389, 39, 39, 39, 8032, 4117, 24525, 2304, 3224, 37495, 22653, 3714, 43020, 8717, 34268, 26890, 3224, 2423, 32277, 2304, 16247, 34740, 5296, 39184, 286, 539, 268, 1229, 1398], "avg_logprob": -0.31297830659516, "compression_ratio": 1.225, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1001.36, "end": 1001.8, "word": "لو", "probability": 0.8017578125}, {"start": 1001.8, "end": 1002.52, "word": " حكيتلكم", "probability": 0.785400390625}, {"start": 1002.52, "end": 1003.26, "word": " بالامتحان", "probability": 0.95654296875}, {"start": 1003.26, "end": 1003.84, "word": " الـ", "probability": 0.4534912109375}, {"start": 1003.84, "end": 1004.4, "word": " D1", "probability": 0.68115234375}, {"start": 1004.4, "end": 1004.94, "word": " أو", "probability": 0.8173828125}, {"start": 1004.94, "end": 1005.42, "word": " الـ", 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"end": 1207.27, "text": "بتجاه الموجب يعني أفهم شحنته بتكون ثالث تمام؟", "tokens": [3555, 2655, 7435, 40294, 9673, 29245, 3555, 37495, 22653, 5551, 5172, 16095, 13412, 5016, 29399, 3224, 39894, 30544, 38637, 6027, 12984, 46811, 10943, 22807], "avg_logprob": -0.34749999046325686, "compression_ratio": 1.0921052631578947, "no_speech_prob": 1.6093254089355469e-06, "words": [{"start": 1200.65, "end": 1202.73, "word": "بتجاه", "probability": 0.5744781494140625}, {"start": 1202.73, "end": 1203.53, "word": " الموجب", "probability": 0.8738606770833334}, {"start": 1203.53, "end": 1203.81, "word": " يعني", "probability": 0.6094970703125}, {"start": 1203.81, "end": 1204.25, "word": " أفهم", "probability": 0.8556315104166666}, {"start": 1204.25, "end": 1204.89, "word": " شحنته", "probability": 0.8887939453125}, {"start": 1204.89, "end": 1205.73, "word": " بتكون", "probability": 0.7490234375}, {"start": 1205.73, "end": 1206.45, "word": " ثالث", "probability": 0.8697916666666666}, {"start": 1206.45, 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هيصيرلها damage وبالتالي هيصيرلهم release هيطلع من عضلة القلب إلى إبلاذ مادة وبالتالي LD1 و LD2 هيزيد تركيزهم في إبلاذ مادة من 2 ل10", "tokens": [5172, 10721, 1829, 37893, 28820, 3660, 45030, 11242, 37977, 25062, 46152, 33936, 16, 4032, 33936, 17, 6225, 11242, 37977, 25062, 46152, 39896, 9381, 13546, 1211, 11296, 4344, 46599, 6027, 2655, 6027, 1829, 39896, 9381, 13546, 1211, 16095, 4374, 39896, 9566, 1211, 3615, 9154, 6225, 11242, 37977, 25062, 46152, 30731, 11933, 3555, 15040, 8848, 3714, 18513, 3660, 4032, 3555, 6027, 2655, 6027, 1829, 33936, 16, 4032, 33936, 17, 39896, 11622, 25708, 6055, 31747, 1829, 11622, 16095, 8978, 11933, 3555, 15040, 8848, 3714, 18513, 3660, 9154, 568, 5296, 3279], "avg_logprob": -0.15145596827973018, "compression_ratio": 1.8012422360248448, "no_speech_prob": 8.344650268554688e-07, "words": [{"start": 1338.91, "end": 1339.61, "word": "فأي", "probability": 0.8175455729166666}, {"start": 1339.61, "end": 1340.21, "word": " مشكلة", "probability": 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بعضلة", "probability": 0.777099609375}, {"start": 1380.68, "end": 1381.12, "word": " القلب", "probability": 0.99609375}, {"start": 1381.12, "end": 1382.16, "word": " بتركيز", "probability": 0.8214111328125}, {"start": 1382.16, "end": 1382.88, "word": " عالية", "probability": 0.9871419270833334}, {"start": 1382.88, "end": 1383.66, "word": " تمام؟", "probability": 0.9417317708333334}], "temperature": 1.0}, {"id": 65, "seek": 141331, "start": 1384.19, "end": 1413.31, "text": "if problem is not myocardial infarction يعني لو كانت المشكلة مشكلة بالقلب ولكن مش ذبحة قلبية both LD1 و LD2 rise أكيد مش صار عندي مشكلة بعضلة القلب تمام صار عندي مشكلة بعضلة القلب هيطلع LD1 و LD2 من عضلة القلب لبلازمة دم وبالتالي التانين هيزيدوا LD1 و LD2 في بلازمة دم هيزيدوا", "tokens": [351, 1154, 307, 406, 452, 905, 515, 831, 1536, 289, 882, 37495, 22653, 45164, 25961, 2655, 9673, 8592, 28820, 3660, 37893, 28820, 3660, 20666, 4587, 46152, 35525, 19452, 37893, 29910, 49628, 3660, 12174, 46152, 10632, 1293, 33936, 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عضلة", "probability": 0.9876302083333334}, {"start": 1405.89, "end": 1406.27, "word": " القلب", "probability": 0.996337890625}, {"start": 1406.27, "end": 1406.91, "word": " لبلازمة", "probability": 0.8205078125}, {"start": 1406.91, "end": 1407.21, "word": " دم", "probability": 0.927490234375}, {"start": 1407.21, "end": 1408.37, "word": " وبالتالي", "probability": 0.96416015625}, {"start": 1408.37, "end": 1408.95, "word": " التانين", "probability": 0.73095703125}, {"start": 1408.95, "end": 1409.79, "word": " هيزيدوا", "probability": 0.967529296875}, {"start": 1409.79, "end": 1410.63, "word": " LD1", "probability": 0.847900390625}, {"start": 1410.63, "end": 1410.85, "word": " و", "probability": 0.9951171875}, {"start": 1410.85, "end": 1411.45, "word": " LD2", "probability": 0.925048828125}, {"start": 1411.45, "end": 1411.69, "word": " في", "probability": 0.96337890625}, {"start": 1411.69, "end": 1412.29, "word": " بلازمة", "probability": 0.9495849609375}, {"start": 1412.29, "end": 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"probability": 0.8946533203125}, {"start": 1536.91, "end": 1537.79, "word": " LD1", "probability": 0.94970703125}, {"start": 1537.79, "end": 1538.89, "word": " أعلى،", "probability": 0.92919921875}, {"start": 1538.89, "end": 1539.67, "word": " وبالتالي،", "probability": 0.884765625}, {"start": 1539.67, "end": 1540.45, "word": " LD1", "probability": 0.96484375}, {"start": 1540.45, "end": 1540.67, "word": " اللي", "probability": 0.953369140625}, {"start": 1540.67, "end": 1541.25, "word": " تركيزه", "probability": 0.9884765625}, {"start": 1541.25, "end": 1541.85, "word": " أعلى،", "probability": 0.957275390625}, {"start": 1541.85, "end": 1542.01, "word": " لو", "probability": 0.9501953125}, {"start": 1542.01, "end": 1542.69, "word": " جسمته", "probability": 0.94677734375}, {"start": 1542.69, "end": 1542.87, "word": " على", "probability": 0.9443359375}, {"start": 1542.87, "end": 1543.61, "word": " LD2", "probability": 0.98681640625}, {"start": 1543.61, "end": 1543.83, "word": " اللي", "probability": 0.97705078125}, {"start": 1543.83, "end": 1544.47, "word": " تركيزه", "probability": 0.99599609375}, {"start": 1544.47, "end": 1545.65, "word": " أقل،", "probability": 0.991943359375}, {"start": 1545.65, "end": 1545.77, "word": " إيش", "probability": 0.9114583333333334}, {"start": 1545.77, "end": 1546.23, "word": " هتصير", "probability": 0.9368896484375}, {"start": 1546.23, "end": 1546.45, "word": " الـ", "probability": 0.879638671875}, {"start": 1546.45, "end": 1546.93, "word": " Ratio؟", "probability": 0.7561848958333334}, {"start": 1546.93, "end": 1547.61, "word": " هتصير", "probability": 0.969970703125}, {"start": 1547.61, "end": 1548.37, "word": " أعلى", "probability": 0.9773763020833334}, {"start": 1548.37, "end": 1548.73, "word": " من", "probability": 0.9970703125}, {"start": 1548.73, "end": 1549.67, "word": " 1،", "probability": 0.790283203125}, {"start": 1549.67, "end": 1550.25, "word": " تمام؟", "probability": 0.9793294270833334}], "temperature": 1.0}, {"id": 72, "seek": 157097, "start": 1550.93, "end": 1570.97, "text": "إذاً بدنا نشوف شغلتان في الإنسان الطبيعي LD2 أعلى من LD1 فلو جسمت تركيز LD1 على LD2 حاصل القسمة هيطلع أجل من 1 تمام؟ هذا الإنسان الهلفي", "tokens": [28814, 15730, 14111, 47525, 8315, 8717, 8592, 38688, 13412, 17082, 1211, 2655, 7649, 8978, 33688, 1863, 3794, 7649, 41950, 21292, 3615, 1829, 33936, 17, 5551, 3615, 23942, 9154, 33936, 16, 6156, 1211, 2407, 10874, 38251, 2655, 6055, 31747, 1829, 11622, 33936, 16, 15844, 33936, 17, 11331, 33546, 1211, 25062, 38251, 3660, 39896, 9566, 1211, 3615, 5551, 7435, 1211, 9154, 502, 46811, 10943, 22807, 23758, 33688, 1863, 3794, 7649, 2423, 3224, 1211, 41185], "avg_logprob": -0.1285316764491878, "compression_ratio": 1.5098039215686274, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1550.93, "end": 1551.65, "word": "إذاً", "probability": 0.6492513020833334}, {"start": 1551.65, "end": 1552.19, "word": " بدنا", "probability": 0.78759765625}, {"start": 1552.19, "end": 1552.71, 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{"start": 1835.08, "end": 1836.72, "word": " 225", "probability": 0.84814453125}, {"start": 1836.72, "end": 1837.18, "word": " هذا", "probability": 0.62548828125}, {"start": 1837.18, "end": 1837.84, "word": " تركيز", "probability": 0.9827880859375}, {"start": 1837.84, "end": 1838.38, "word": " الإنزايم", "probability": 0.92373046875}, {"start": 1838.38, "end": 1839.1, "word": " international", "probability": 0.361328125}, {"start": 1839.1, "end": 1839.96, "word": " unit", "probability": 0.9189453125}, {"start": 1839.96, "end": 1840.4, "word": " per", "probability": 0.8896484375}, {"start": 1840.4, "end": 1840.92, "word": " liter", "probability": 0.8076171875}, {"start": 1840.92, "end": 1841.8, "word": " هذا", "probability": 0.82177734375}, {"start": 1841.8, "end": 1842.36, "word": " الـ", "probability": 0.75048828125}, {"start": 1842.36, "end": 1842.62, "word": " normal", "probability": 0.7353515625}, {"start": 1842.62, "end": 1843.2, "word": " range", "probability": 0.953125}, 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4117, 15844, 4032, 11242, 3615, 6225, 11242, 37977, 25062, 46152, 24525, 2304, 3224, 2423, 39184, 9419, 13672, 1829, 31439, 33251, 16572, 9307, 9957, 9122, 9957, 1829, 11622, 5551, 4117, 8592, 1863, 25124, 17082, 1211, 23758, 2423, 39184, 16257, 1229, 1398, 8978, 25724, 38251, 12399, 341, 24521, 307, 6615, 365, 264, 43813, 293, 6725, 295, 1090, 2281, 46542, 39202], "avg_logprob": -0.19116512051335088, "compression_ratio": 1.4363636363636363, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1872.16, "end": 1872.94, "word": "الـMarker", "probability": 0.653594970703125}, {"start": 1872.94, "end": 1873.84, "word": " التاني،", "probability": 0.8892822265625}, {"start": 1873.84, "end": 1874.52, "word": " الـEnzyme", "probability": 0.81689453125}, {"start": 1874.52, "end": 1875.1, "word": " التاني", "probability": 0.9939778645833334}, {"start": 1875.1, "end": 1875.38, "word": " اللي", "probability": 0.951416015625}, {"start": 1875.38, "end": 1875.94, "word": " بيشيك", "probability": 0.9552734375}, {"start": 1875.94, "end": 1876.2, "word": " على", "probability": 0.86962890625}, {"start": 1876.2, "end": 1876.86, "word": " وضع", "probability": 0.9864908854166666}, {"start": 1876.86, "end": 1877.46, "word": " عضلة", "probability": 0.9542643229166666}, {"start": 1877.46, "end": 1877.98, "word": " القلب", "probability": 0.99755859375}, {"start": 1877.98, "end": 1878.64, "word": " اسمه", "probability": 0.9368489583333334}, {"start": 1878.64, "end": 1879.54, "word": " الـCK", "probability": 0.8406575520833334}, {"start": 1879.54, "end": 1880.3, "word": " اللي", "probability": 0.9189453125}, {"start": 1880.3, "end": 1880.54, "word": " هو", "probability": 0.98779296875}, {"start": 1880.54, "end": 1881.5, "word": " الكرياتين", "probability": 0.67169189453125}, {"start": 1881.5, "end": 1882.38, "word": " كينيز", "probability": 0.7420654296875}, {"start": 1882.38, "end": 1883.54, "word": " أكشن", "probability": 0.71881103515625}, {"start": 1883.54, "end": 1884.24, "word": " الشغل", "probability": 0.95703125}, {"start": 1884.24, "end": 1884.48, "word": " هذا", "probability": 0.900390625}, {"start": 1884.48, "end": 1885.18, "word": " الـEnzyme", "probability": 0.83330078125}, {"start": 1885.18, "end": 1885.38, "word": " في", "probability": 0.97021484375}, {"start": 1885.38, "end": 1886.42, "word": " الجسم،", "probability": 0.8302408854166666}, {"start": 1886.42, "end": 1886.68, "word": " this", "probability": 0.55224609375}, {"start": 1886.68, "end": 1887.38, "word": " enzyme", "probability": 0.9560546875}, {"start": 1887.38, "end": 1887.96, "word": " is", "probability": 0.9501953125}, {"start": 1887.96, "end": 1888.9, "word": " associated", "probability": 0.92626953125}, {"start": 1888.9, "end": 1889.46, "word": " with", "probability": 0.931640625}, {"start": 1889.46, "end": 1889.7, "word": " the", "probability": 0.76025390625}, {"start": 1889.7, "end": 1890.34, "word": " regeneration", "probability": 0.9638671875}, {"start": 1890.34, "end": 1891.0, "word": " and", "probability": 0.9501953125}, {"start": 1891.0, "end": 1891.46, "word": " storage", "probability": 0.90185546875}, {"start": 1891.46, "end": 1891.78, "word": " of", "probability": 0.982421875}, {"start": 1891.78, "end": 1892.12, "word": " high", "probability": 0.880859375}, {"start": 1892.12, "end": 1892.74, "word": " energy", "probability": 0.58154296875}, {"start": 1892.74, "end": 1893.48, "word": " phosphate", "probability": 0.95166015625}, {"start": 1893.48, "end": 1894.08, "word": " ATP", "probability": 0.56005859375}], "temperature": 1.0}, {"id": 87, "seek": 191828, "start": 1894.96, "end": 1918.28, "text": "وظيفة هذا الـ enzyme في الجسم إنه مسؤول عن توليد الطاقة الـ regeneration إنتاج طاقة and storage وتخزين الطاقة يعني في حال الجسم احتاج لطاقة وبالأخص العضلات في حال احتاجت لطاقة الـCK بيشتغل وبيعملها regeneration بيطلعلها طاقة", "tokens": [2407, 19913, 33911, 3660, 23758, 2423, 39184, 24521, 8978, 25724, 38251, 36145, 3224, 47524, 33604, 12610, 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{"start": 1896.58, "end": 1896.88, "word": " في", "probability": 0.98046875}, {"start": 1896.88, "end": 1897.66, "word": " الجسم", "probability": 0.988037109375}, {"start": 1897.66, "end": 1898.52, "word": " إنه", "probability": 0.7548828125}, {"start": 1898.52, "end": 1899.2, "word": " مسؤول", "probability": 0.8346354166666666}, {"start": 1899.2, "end": 1899.64, "word": " عن", "probability": 0.9921875}, {"start": 1899.64, "end": 1900.62, "word": " توليد", "probability": 0.8523763020833334}, {"start": 1900.62, "end": 1901.22, "word": " الطاقة", "probability": 0.9912109375}, {"start": 1901.22, "end": 1901.62, "word": " الـ", "probability": 0.782470703125}, {"start": 1901.62, "end": 1902.14, "word": " regeneration", "probability": 0.6484375}, {"start": 1902.14, "end": 1903.24, "word": " إنتاج", "probability": 0.7635904947916666}, {"start": 1903.24, "end": 1903.68, "word": " طاقة", "probability": 0.9816080729166666}, {"start": 1903.68, "end": 1904.2, "word": " and", "probability": 0.8515625}, {"start": 1904.2, "end": 1904.84, "word": " storage", "probability": 0.87109375}, {"start": 1904.84, "end": 1906.16, "word": " وتخزين", "probability": 0.916748046875}, {"start": 1906.16, "end": 1906.9, "word": " الطاقة", "probability": 0.99609375}, {"start": 1906.9, "end": 1907.2, "word": " يعني", "probability": 0.74609375}, {"start": 1907.2, "end": 1907.38, "word": " في", "probability": 0.97607421875}, {"start": 1907.38, "end": 1907.74, "word": " حال", "probability": 0.996337890625}, {"start": 1907.74, "end": 1908.34, "word": " الجسم", "probability": 0.96875}, {"start": 1908.34, "end": 1909.24, "word": " احتاج", "probability": 0.8541666666666666}, {"start": 1909.24, "end": 1909.82, "word": " لطاقة", "probability": 0.98046875}, {"start": 1909.82, "end": 1910.76, "word": " وبالأخص", "probability": 0.8837890625}, {"start": 1910.76, "end": 1911.6, "word": " العضلات", "probability": 0.9876708984375}, {"start": 1911.6, "end": 1912.12, "word": " في", "probability": 0.923828125}, {"start": 1912.12, "end": 1912.5, "word": " حال", "probability": 0.996826171875}, {"start": 1912.5, "end": 1913.2, "word": " احتاجت", "probability": 0.895263671875}, {"start": 1913.2, "end": 1913.76, "word": " لطاقة", "probability": 0.986083984375}, {"start": 1913.76, "end": 1914.72, "word": " الـCK", "probability": 0.8684895833333334}, {"start": 1914.72, "end": 1915.44, "word": " بيشتغل", "probability": 0.959228515625}, {"start": 1915.44, "end": 1916.18, "word": " وبيعملها", "probability": 0.88837890625}, {"start": 1916.18, "end": 1916.94, "word": " regeneration", "probability": 0.830078125}, {"start": 1916.94, "end": 1917.86, "word": " بيطلعلها", "probability": 0.866455078125}, {"start": 1917.86, "end": 1918.28, "word": " طاقة", "probability": 0.99462890625}], "temperature": 1.0}, {"id": 88, "seek": 193424, "start": 1918.9, "end": 1934.24, "text": "تمام؟ لكن في حال العضلات كان عندها فائد من الـ ATP فائد من هذه الطاقة هذا الـ enzyme مسئول انه يعمل storage مسئول انه يخزن الطاقة الفائدة تمام؟", "tokens": [39237, 10943, 22807, 44381, 8978, 11331, 6027, 18863, 11242, 1211, 9307, 25961, 43242, 11296, 6156, 16373, 3215, 9154, 2423, 39184, 39202, 6156, 16373, 3215, 9154, 29538, 41950, 995, 28671, 23758, 2423, 39184, 24521, 47524, 19986, 12610, 16472, 3224, 7251, 25957, 1211, 6725, 47524, 19986, 12610, 16472, 3224, 7251, 9778, 11622, 1863, 41950, 995, 28671, 27188, 16373, 41891, 46811, 10943, 22807], "avg_logprob": -0.14626024199313806, "compression_ratio": 1.588235294117647, "no_speech_prob": 2.7418136596679688e-06, "words": [{"start": 1918.9, "end": 1919.62, "word": "تمام؟", "probability": 0.5799560546875}, {"start": 1919.62, "end": 1919.96, "word": " لكن", "probability": 0.93896484375}, {"start": 1919.96, "end": 1920.2, "word": " في", "probability": 0.9521484375}, {"start": 1920.2, "end": 1920.48, "word": " حال", "probability": 0.995361328125}, {"start": 1920.48, "end": 1921.06, "word": " العضلات", "probability": 0.978271484375}, {"start": 1921.06, "end": 1921.28, "word": " كان", "probability": 0.96728515625}, {"start": 1921.28, "end": 1921.7, "word": " عندها", "probability": 0.995849609375}, {"start": 1921.7, "end": 1922.54, "word": " فائد", "probability": 0.861328125}, {"start": 1922.54, "end": 1922.92, "word": " من", "probability": 0.97900390625}, {"start": 1922.92, "end": 1923.22, "word": " الـ", "probability": 0.971923828125}, {"start": 1923.22, "end": 1923.62, "word": " ATP", "probability": 0.63037109375}, {"start": 1923.62, "end": 1924.28, "word": " فائد", "probability": 0.90185546875}, {"start": 1924.28, "end": 1924.44, "word": " من", "probability": 0.99462890625}, {"start": 1924.44, "end": 1924.78, "word": " هذه", "probability": 0.89404296875}, {"start": 1924.78, "end": 1925.32, "word": " الطاقة", "probability": 0.9915364583333334}, {"start": 1925.32, "end": 1926.12, "word": " هذا", "probability": 0.465576171875}, {"start": 1926.12, "end": 1926.34, "word": " الـ", "probability": 0.783935546875}, {"start": 1926.34, "end": 1926.76, "word": " enzyme", "probability": 0.8369140625}, {"start": 1926.76, "end": 1927.42, "word": " مسئول", "probability": 0.9225260416666666}, {"start": 1927.42, "end": 1927.72, "word": " انه", "probability": 0.5859375}, {"start": 1927.72, "end": 1928.06, "word": " يعمل", "probability": 0.9833984375}, {"start": 1928.06, "end": 1928.6, "word": " storage", "probability": 0.469482421875}, {"start": 1928.6, "end": 1929.44, "word": " مسئول", "probability": 0.94091796875}, {"start": 1929.44, "end": 1930.3, "word": " انه", "probability": 0.92333984375}, {"start": 1930.3, "end": 1931.86, "word": " يخزن", "probability": 0.9468994140625}, {"start": 1931.86, "end": 1932.48, "word": " الطاقة", "probability": 0.9952799479166666}, {"start": 1932.48, "end": 1933.42, "word": " الفائدة", "probability": 0.9775390625}, {"start": 1933.42, "end": 1934.24, "word": " تمام؟", "probability": 0.8675130208333334}], "temperature": 1.0}, {"id": 89, "seek": 195467, "start": 1935.21, "end": 1954.67, "text": "It catalyzes the following reversible reaction in the body التفاعل بيمشي باتجاهين إما forward أو reversible حسب حاجة الجسم كيف؟ في حال الجسم كان عنده فائض وخاصة في العضلات يعني هذا ال reaction أكتر إش بيصير في العضلات", "tokens": [3522, 3857, 5222, 12214, 264, 3480, 44788, 5480, 294, 264, 1772, 16712, 5172, 995, 30241, 4724, 32640, 8592, 1829, 4724, 9307, 7435, 40294, 9957, 11933, 15042, 2128, 34051, 44788, 11331, 35457, 11331, 26108, 3660, 25724, 38251, 9122, 33911, 22807, 8978, 11331, 6027, 25724, 38251, 25961, 43242, 3224, 6156, 16373, 11242, 4032, 9778, 33546, 3660, 8978, 18863, 11242, 1211, 9307, 37495, 22653, 23758, 2423, 5480, 5551, 4117, 2655, 2288, 11933, 8592, 4724, 1829, 9381, 13546, 8978, 18863, 11242, 1211, 9307], "avg_logprob": -0.14658203125, "compression_ratio": 1.5188679245283019, "no_speech_prob": 0.0, "words": [{"start": 1935.21, "end": 1935.47, "word": "It", "probability": 0.34326171875}, {"start": 1935.47, "end": 1936.35, "word": " catalyzes", "probability": 0.8505859375}, {"start": 1936.35, "end": 1936.59, "word": " the", "probability": 0.6083984375}, {"start": 1936.59, "end": 1937.27, "word": " following", "probability": 0.888671875}, {"start": 1937.27, "end": 1938.15, "word": " reversible", "probability": 0.86083984375}, {"start": 1938.15, "end": 1938.97, "word": " reaction", "probability": 0.91162109375}, {"start": 1938.97, "end": 1939.35, "word": " in", "probability": 0.955078125}, {"start": 1939.35, "end": 1939.49, "word": " the", "probability": 0.923828125}, {"start": 1939.49, "end": 1939.73, "word": " body", "probability": 0.86865234375}, {"start": 1939.73, "end": 1940.81, "word": " التفاعل", "probability": 0.912109375}, {"start": 1940.81, "end": 1941.51, "word": " بيمشي", "probability": 0.8673095703125}, {"start": 1941.51, "end": 1942.23, "word": " باتجاهين", "probability": 0.9587890625}, {"start": 1942.23, "end": 1942.57, "word": " إما", "probability": 0.70849609375}, {"start": 1942.57, "end": 1943.13, "word": " forward", "probability": 0.72900390625}, {"start": 1943.13, "end": 1943.51, "word": " أو", "probability": 0.96630859375}, {"start": 1943.51, "end": 1944.37, "word": " reversible", "probability": 0.96044921875}, {"start": 1944.37, "end": 1945.33, "word": " حسب", "probability": 0.909912109375}, {"start": 1945.33, "end": 1945.97, "word": " حاجة", "probability": 0.9957682291666666}, {"start": 1945.97, "end": 1946.47, "word": " الجسم", "probability": 0.984619140625}, {"start": 1946.47, "end": 1947.77, "word": " كيف؟", "probability": 0.8444010416666666}, {"start": 1947.77, "end": 1947.91, "word": " في", "probability": 0.83935546875}, {"start": 1947.91, "end": 1948.23, "word": " حال", "probability": 0.9931640625}, {"start": 1948.23, "end": 1948.79, "word": " الجسم", "probability": 0.986328125}, {"start": 1948.79, "end": 1949.35, "word": " كان", "probability": 0.9873046875}, {"start": 1949.35, "end": 1949.83, "word": " عنده", "probability": 0.977783203125}, {"start": 1949.83, "end": 1950.33, "word": " فائض", "probability": 0.6741536458333334}, {"start": 1950.33, "end": 1950.93, "word": " وخاصة", "probability": 0.8668212890625}, {"start": 1950.93, "end": 1951.01, "word": " في", "probability": 0.89501953125}, {"start": 1951.01, "end": 1951.61, "word": " العضلات", "probability": 0.9913330078125}, {"start": 1951.61, "end": 1951.85, "word": " يعني", "probability": 0.81787109375}, {"start": 1951.85, "end": 1952.09, "word": " هذا", "probability": 0.818359375}, {"start": 1952.09, "end": 1952.17, "word": " ال", "probability": 0.58837890625}, {"start": 1952.17, "end": 1952.63, "word": " reaction", "probability": 0.8544921875}, {"start": 1952.63, "end": 1953.05, "word": " أكتر", "probability": 0.984619140625}, {"start": 1953.05, "end": 1953.23, "word": " إش", "probability": 0.5732421875}, {"start": 1953.23, "end": 1953.65, "word": " بيصير", "probability": 0.8529052734375}, {"start": 1953.65, "end": 1953.85, "word": " في", "probability": 0.98291015625}, {"start": 1953.85, "end": 1954.67, "word": " 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موجودين في البلازم الدم بشكل طبيعي و at low concentration وبتركيز قليلة، موجودين في البلازم الدم ولكن موجودين بتركيز عالية في أعضاء الجسم المختلفة", "tokens": [9419, 16, 4032, 9419, 17, 4032, 9419, 18, 12399, 46811, 10943, 22807, 8032, 3215, 12610, 16712, 1211, 2655, 8717, 19913, 16373, 2288, 8717, 36178, 2423, 28820, 10943, 3714, 29245, 23328, 9957, 8978, 29739, 1211, 31377, 2304, 32748, 2304, 4724, 8592, 28820, 23032, 21292, 3615, 1829, 4032, 412, 2295, 9856, 46599, 2655, 31747, 1829, 11622, 12174, 20292, 37977, 12399, 3714, 29245, 23328, 9957, 8978, 29739, 1211, 31377, 2304, 32748, 2304, 35525, 19452, 3714, 29245, 23328, 9957, 39894, 31747, 1829, 11622, 6225, 6027, 10632, 8978, 5551, 3615, 11242, 16606, 25724, 38251, 9673, 46456, 46538, 3660], "avg_logprob": -0.11959773587419632, "compression_ratio": 1.6802030456852792, "no_speech_prob": 6.556510925292969e-07, "words": [{"start": 2094.1, "end": 2095.14, "word": "CK1", "probability": 0.68603515625}, {"start": 2095.14, "end": 2096.48, 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تركيز كل إنزايم على حدى بلجأ لتقنية الـ Electrophoresis تعطيلي تركيز كل إنزايم على حدى، تمام؟ إذا هاي عندنا في الجدول CK1، الإسم الآخر له BB هدول إنه كل إيزو إنزايم زي ما حكينا عن الـLDH", "tokens": [1211, 2407, 4724, 16254, 5551, 3615, 28480, 6055, 31747, 1829, 11622, 28242, 36145, 11622, 995, 32640, 15844, 11331, 3215, 7578, 4724, 1211, 7435, 10721, 5296, 2655, 4587, 1863, 10632, 2423, 39184, 12575, 11741, 2706, 271, 6055, 3615, 9566, 1829, 20292, 6055, 31747, 1829, 11622, 28242, 36145, 11622, 995, 32640, 15844, 11331, 3215, 7578, 12399, 46811, 10943, 22807, 11933, 15730, 8032, 47302, 43242, 8315, 8978, 25724, 3215, 12610, 383, 42, 16, 12399, 33688, 38251, 6024, 95, 34740, 46740, 19168, 8032, 3215, 12610, 36145, 3224, 28242, 11933, 1829, 11622, 2407, 36145, 11622, 995, 32640, 30767, 1829, 19446, 11331, 4117, 1829, 8315, 18871, 2423, 39184, 23704, 39], "avg_logprob": -0.19315476076943533, "compression_ratio": 1.6341463414634145, "no_speech_prob": 0.0, "words": [{"start": 2133.15, 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{"start": 2334.6, "end": 2334.94, "word": " أنا", "probability": 0.83154296875}, {"start": 2334.94, "end": 2335.22, "word": " مين", "probability": 0.9794921875}, {"start": 2335.22, "end": 2335.86, "word": " بيعنيني", "probability": 0.769287109375}, {"start": 2335.86, "end": 2336.36, "word": " أكتر", "probability": 0.975830078125}, {"start": 2336.36, "end": 2336.82, "word": " واحد", "probability": 0.994384765625}, {"start": 2336.82, "end": 2338.64, "word": " الـCK2", "probability": 0.7061767578125}, {"start": 2338.64, "end": 2339.98, "word": " تمام؟", "probability": 0.7957356770833334}, {"start": 2339.98, "end": 2340.24, "word": " بدي", "probability": 0.81787109375}, {"start": 2340.24, "end": 2340.96, "word": " أحكيلكم", "probability": 0.9203287760416666}, {"start": 2340.96, "end": 2341.42, "word": " شغلة", "probability": 0.9210611979166666}, {"start": 2341.42, "end": 2341.92, "word": " عندنا", "probability": 0.855712890625}, {"start": 2341.92, "end": 2342.04, "word": " في", 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"end": 2359.86, "word": " كتات", "probability": 0.9930013020833334}, {"start": 2359.86, "end": 2361.04, "word": " خاصة", "probability": 0.9754231770833334}, {"start": 2361.04, "end": 2361.24, "word": " فيه", "probability": 0.91796875}, {"start": 2361.24, "end": 2361.8, "word": " عملوله", "probability": 0.948974609375}, {"start": 2361.8, "end": 2362.06, "word": " كت", "probability": 0.686279296875}, {"start": 2362.06, "end": 2362.28, "word": " لأن", "probability": 0.775634765625}, {"start": 2362.28, "end": 2362.5, "word": " هو", "probability": 0.63525390625}, {"start": 2362.5, "end": 2363.44, "word": " متخصص", "probability": 0.9854736328125}, {"start": 2363.44, "end": 2364.04, "word": " لعدلة", "probability": 0.8194986979166666}, {"start": 2364.04, "end": 2364.98, "word": " القلب،", "probability": 0.7643229166666666}, {"start": 2364.98, "end": 2365.64, "word": " تمام؟", "probability": 0.9078776041666666}, {"start": 2365.64, "end": 2365.88, "word": " يعني", "probability": 0.9345703125}, 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2585.09, "end": 2585.55, "word": " acute", "probability": 0.49365234375}, {"start": 2585.55, "end": 2586.31, "word": " myocardial", "probability": 0.966552734375}, {"start": 2586.31, "end": 2586.93, "word": " infarction", "probability": 0.8068033854166666}, {"start": 2586.93, "end": 2587.17, "word": " ولا", "probability": 0.576171875}, {"start": 2587.17, "end": 2587.49, "word": " لا", "probability": 0.75341796875}, {"start": 2587.49, "end": 2588.15, "word": " اعمليه", "probability": 0.6549072265625}, {"start": 2588.15, "end": 2588.69, "word": " فحسين", "probability": 0.79742431640625}, {"start": 2588.69, "end": 2589.15, "word": " الـ", "probability": 0.88330078125}, {"start": 2589.15, "end": 2589.39, "word": " Total", "probability": 0.7265625}, {"start": 2589.39, "end": 2590.05, "word": " CK", "probability": 0.971923828125}, {"start": 2590.05, "end": 2590.89, "word": " والـ", "probability": 0.6728515625}, {"start": 2590.89, "end": 2591.59, "word": " CK2", "probability": 0.9544270833333334}], "temperature": 1.0}, {"id": 120, "seek": 260273, "start": 2592.79, "end": 2602.73, "text": "وروحي جسمي تركيز الـ CK2 تركيز النظير على الـ Total CK لو طلعت ال ratio", "tokens": [13063, 2407, 5016, 1829, 10874, 38251, 1829, 6055, 31747, 1829, 11622, 2423, 39184, 383, 42, 17, 6055, 31747, 1829, 11622, 28239, 19913, 13546, 15844, 2423, 39184, 23170, 383, 42, 45164, 23032, 1211, 34268, 2423, 8509], "avg_logprob": -0.2259114570915699, "compression_ratio": 1.2282608695652173, "no_speech_prob": 4.172325134277344e-07, "words": [{"start": 2592.79, "end": 2593.39, "word": "وروحي", "probability": 0.720703125}, {"start": 2593.39, "end": 2593.99, "word": " جسمي", "probability": 0.962890625}, {"start": 2593.99, "end": 2594.95, "word": " تركيز", "probability": 0.97216796875}, {"start": 2594.95, "end": 2595.17, "word": " الـ", "probability": 0.953369140625}, {"start": 2595.17, "end": 2596.29, "word": " CK2", "probability": 0.4193115234375}, {"start": 2596.29, "end": 2597.19, "word": " تركيز", "probability": 0.866455078125}, {"start": 2597.19, "end": 2597.81, "word": " النظير", "probability": 0.9034830729166666}, {"start": 2597.81, "end": 2598.45, "word": " على", "probability": 0.8212890625}, {"start": 2598.45, "end": 2599.15, "word": " الـ", "probability": 0.949951171875}, {"start": 2599.15, "end": 2599.57, "word": " Total", "probability": 0.73681640625}, {"start": 2599.57, "end": 2600.31, "word": " CK", "probability": 0.9345703125}, {"start": 2600.31, "end": 2600.97, "word": " لو", "probability": 0.75}, {"start": 2600.97, "end": 2601.73, "word": " طلعت", "probability": 0.9890950520833334}, {"start": 2601.73, "end": 2602.19, "word": " ال", "probability": 0.9345703125}, {"start": 2602.19, "end": 2602.73, "word": " ratio", "probability": 0.501953125}], "temperature": 1.0}, {"id": 121, "seek": 262609, "start": 2604.01, "end": 2626.09, "text": "أقل من 6%، إذًا هذا إنسان سليم طبعًا، أنا أحكي لك 6%، انت هتجسمي تركيز الـCK2 على تركيز الـ TotalCK درجة 100%، تمام؟ لو طلعت النتيجة أقل من 6%، هذا إنسان سليم", "tokens": [10721, 4587, 1211, 9154, 1386, 4, 12399, 11933, 8848, 14111, 995, 23758, 36145, 3794, 7649, 8608, 20292, 2304, 23032, 3555, 3615, 14111, 995, 12399, 41850, 5551, 5016, 4117, 1829, 5296, 4117, 1386, 4, 12399, 16472, 2655, 8032, 2655, 7435, 38251, 1829, 6055, 31747, 1829, 11622, 2423, 39184, 9419, 17, 15844, 6055, 31747, 1829, 11622, 2423, 39184, 23170, 9419, 11778, 47341, 3660, 2319, 4, 12399, 46811, 10943, 22807, 45164, 23032, 1211, 34268, 28239, 31371, 7435, 3660, 5551, 4587, 1211, 9154, 1386, 4, 12399, 23758, 36145, 3794, 7649, 8608, 20292, 2304], "avg_logprob": -0.18993056184715695, "compression_ratio": 1.5773809523809523, "no_speech_prob": 2.980232238769531e-07, "words": [{"start": 2604.01, "end": 2604.59, "word": "أقل", "probability": 0.89404296875}, {"start": 2604.59, "end": 2604.87, "word": " من", "probability": 0.98681640625}, {"start": 2604.87, "end": 2605.33, "word": " 6", "probability": 0.9873046875}, {"start": 2605.33, "end": 2606.73, "word": "%،", "probability": 0.618896484375}, {"start": 2606.73, "end": 2606.97, "word": " إذًا", "probability": 0.68170166015625}, {"start": 2606.97, "end": 2607.43, "word": " هذا", "probability": 0.86962890625}, {"start": 2607.43, "end": 2608.13, "word": " إنسان", "probability": 0.9734700520833334}, {"start": 2608.13, "end": 2608.55, "word": " سليم", "probability": 0.8802083333333334}, {"start": 2608.55, "end": 2609.25, "word": " طبعًا،", "probability": 0.7902018229166666}, {"start": 2609.25, "end": 2609.29, "word": " أنا", "probability": 0.91845703125}, {"start": 2609.29, "end": 2609.53, "word": " أحكي", "probability": 0.8756103515625}, {"start": 2609.53, "end": 2609.67, "word": " لك", "probability": 0.6783447265625}, {"start": 2609.67, "end": 2609.89, "word": " 6", "probability": 0.94482421875}, {"start": 2609.89, "end": 2610.49, "word": "%،", "probability": 0.804931640625}, {"start": 2610.49, "end": 2610.67, "word": " انت", "probability": 0.6568603515625}, {"start": 2610.67, "end": 2611.59, "word": " هتجسمي", "probability": 0.813818359375}, {"start": 2611.59, "end": 2612.67, "word": " تركيز", "probability": 0.9810791015625}, {"start": 2612.67, "end": 2614.23, "word": " الـCK2", "probability": 0.810302734375}, {"start": 2614.23, "end": 2614.69, "word": " على", "probability": 0.8076171875}, {"start": 2614.69, "end": 2615.79, "word": " تركيز", "probability": 0.9891357421875}, {"start": 2615.79, "end": 2616.41, "word": " الـ", "probability": 0.96435546875}, {"start": 2616.41, "end": 2619.19, "word": " TotalCK", "probability": 0.516845703125}, {"start": 2619.19, "end": 2619.65, "word": " درجة", "probability": 0.6013997395833334}, {"start": 2619.65, "end": 2619.87, "word": " 100", "probability": 0.7568359375}, {"start": 2619.87, "end": 2620.59, "word": "%،", "probability": 0.58447265625}, {"start": 2620.59, "end": 2621.55, "word": " تمام؟", "probability": 0.9791666666666666}, {"start": 2621.55, "end": 2621.79, "word": " لو", "probability": 0.890625}, {"start": 2621.79, "end": 2622.39, "word": " طلعت", "probability": 0.9847005208333334}, {"start": 2622.39, "end": 2623.05, "word": " النتيجة", "probability": 0.9774169921875}, {"start": 2623.05, "end": 2623.39, "word": " أقل", "probability": 0.9599609375}, {"start": 2623.39, "end": 2623.59, "word": " من", "probability": 0.9931640625}, {"start": 2623.59, "end": 2623.93, "word": " 6", "probability": 0.998046875}, {"start": 2623.93, "end": 2624.49, "word": "%،", "probability": 0.887451171875}, {"start": 2624.49, "end": 2624.75, "word": " هذا", "probability": 0.90576171875}, {"start": 2624.75, "end": 2625.51, "word": " إنسان", "probability": 0.9856770833333334}, {"start": 2625.51, "end": 2626.09, "word": " سليم", "probability": 0.986328125}], "temperature": 1.0}, {"id": 122, "seek": 265378, "start": 2626.68, "end": 2653.78, "text": "لو طلعت الـ Ratio أعلى من 6% معناه أكيد في عنده Acute Myocardial Infarction نقرأ Increased CK MB يعني لو طلعت الـ CK MB أعلى بـ 6% من الـ Total CK activity is a strong indication للـ Acute Myocardial Infarction جزده بهذه الجملة", "tokens": [1211, 2407, 23032, 1211, 34268, 2423, 39184, 24269, 1004, 5551, 3615, 23942, 9154, 1386, 4, 20449, 8315, 3224, 5551, 4117, 25708, 8978, 43242, 3224, 5097, 1169, 1222, 905, 515, 831, 11537, 289, 882, 8717, 4587, 2288, 10721, 30367, 1937, 383, 42, 28866, 37495, 22653, 45164, 23032, 1211, 34268, 2423, 39184, 383, 42, 28866, 5551, 3615, 23942, 4724, 39184, 1386, 4, 9154, 2423, 39184, 23170, 383, 42, 5191, 307, 257, 2068, 18877, 24976, 39184, 5097, 1169, 1222, 905, 515, 831, 11537, 289, 882, 10874, 11622, 3215, 3224, 39627, 24192, 25724, 2304, 37977], "avg_logprob": -0.146314544522244, "compression_ratio": 1.495049504950495, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 2626.68, "end": 2627.0, "word": "لو", "probability": 0.988525390625}, {"start": 2627.0, "end": 2627.48, "word": " طلعت", "probability": 0.982421875}, {"start": 2627.48, "end": 2627.74, "word": " الـ", "probability": 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0.86962890625}, {"start": 2634.24, "end": 2635.1, "word": " نقرأ", "probability": 0.8917236328125}, {"start": 2635.1, "end": 2637.18, "word": " Increased", "probability": 0.57183837890625}, {"start": 2637.18, "end": 2638.0, "word": " CK", "probability": 0.739013671875}, {"start": 2638.0, "end": 2638.4, "word": " MB", "probability": 0.276123046875}, {"start": 2638.4, "end": 2639.22, "word": " يعني", "probability": 0.871826171875}, {"start": 2639.22, "end": 2639.7, "word": " لو", "probability": 0.9130859375}, {"start": 2639.7, "end": 2640.26, "word": " طلعت", "probability": 0.9947916666666666}, {"start": 2640.26, "end": 2640.48, "word": " الـ", "probability": 0.9873046875}, {"start": 2640.48, "end": 2640.92, "word": " CK", "probability": 0.852783203125}, {"start": 2640.92, "end": 2641.36, "word": " MB", "probability": 0.92529296875}, {"start": 2641.36, "end": 2642.38, "word": " أعلى", "probability": 0.9762369791666666}, {"start": 2642.38, "end": 2643.1, "word": " بـ", "probability": 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{"start": 2650.48, "end": 2650.78, "word": " Acute", "probability": 0.925048828125}, {"start": 2650.78, "end": 2651.44, "word": " Myocardial", "probability": 0.9903564453125}, {"start": 2651.44, "end": 2652.12, "word": " Infarction", "probability": 0.896484375}, {"start": 2652.12, "end": 2652.9, "word": " جزده", "probability": 0.7218017578125}, {"start": 2652.9, "end": 2653.32, "word": " بهذه", "probability": 0.948974609375}, {"start": 2653.32, "end": 2653.78, "word": " الجملة", "probability": 0.9523111979166666}], "temperature": 1.0}, {"id": 123, "seek": 268268, "start": 2654.18, "end": 2682.68, "text": "لو انت جسمتي تركيز الـCK2 أو الاسم الآخر له الـCKNB جسمتي تركيز النظير على تركيز الـTotal CK وضربت بـ100% طلعت القيمة أجل من أو يساوي 6% إذا هذا إنسان سليم أعلى من 6% إذا بيكون عنده Acute Myocardial Infarction تمام؟", "tokens": [1211, 2407, 16472, 2655, 10874, 38251, 31371, 6055, 31747, 1829, 11622, 2423, 39184, 9419, 17, 34051, 2423, 32277, 2304, 6024, 95, 34740, 46740, 2423, 39184, 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بعد يومين لتلت أيام بيبدأ يرجع طبيعي يعني هو بيضله عالي في الجسم وبعد يومين لتلت أيام من الإصابة بيبدأ يقل ويرجع تركيزه للوضع الطبيعي، تمام؟", "tokens": [2655, 4587, 16572, 3555, 14111, 995, 9154, 7251, 20498, 9957, 5296, 2655, 1211, 2655, 36632, 10943, 39182, 7251, 20498, 9957, 5296, 2655, 1211, 2655, 36632, 10943, 4724, 1829, 44510, 10721, 7251, 47341, 3615, 23032, 21292, 3615, 1829, 37495, 22653, 31439, 4724, 1829, 11242, 43761, 6225, 6027, 1829, 8978, 25724, 38251, 46599, 22488, 7251, 20498, 9957, 5296, 2655, 1211, 2655, 36632, 10943, 9154, 33688, 9381, 16758, 3660, 4724, 1829, 44510, 10721, 7251, 4587, 1211, 4032, 13546, 7435, 3615, 6055, 31747, 1829, 11622, 3224, 24976, 2407, 11242, 3615, 41950, 21292, 3615, 1829, 12399, 46811, 10943, 22807], "avg_logprob": -0.08577302945287604, "compression_ratio": 2.013245033112583, "no_speech_prob": 0.00011086463928222656, "words": [{"start": 2739.42, "end": 2740.52, "word": "تقريبًا", "probability": 0.8658854166666666}, {"start": 2740.52, 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2747.52, "word": " هو", "probability": 0.94970703125}, {"start": 2747.52, "end": 2747.92, "word": " بيضله", "probability": 0.75347900390625}, {"start": 2747.92, "end": 2748.24, "word": " عالي", "probability": 0.9796549479166666}, {"start": 2748.24, "end": 2748.36, "word": " في", "probability": 0.9541015625}, {"start": 2748.36, "end": 2748.84, "word": " الجسم", "probability": 0.98779296875}, {"start": 2748.84, "end": 2749.9, "word": " وبعد", "probability": 0.799560546875}, {"start": 2749.9, "end": 2750.48, "word": " يومين", "probability": 0.9889322916666666}, {"start": 2750.48, "end": 2751.24, "word": " لتلت", "probability": 0.9954833984375}, {"start": 2751.24, "end": 2751.8, "word": " أيام", "probability": 0.96337890625}, {"start": 2751.8, "end": 2752.2, "word": " من", "probability": 0.99462890625}, {"start": 2752.2, "end": 2753.04, "word": " الإصابة", "probability": 0.990478515625}, {"start": 2753.04, "end": 2753.9, "word": " بيبدأ", "probability": 0.9493408203125}, {"start": 2753.9, "end": 2754.46, "word": " يقل", "probability": 0.9969075520833334}, {"start": 2754.46, "end": 2755.16, "word": " ويرجع", "probability": 0.9925537109375}, {"start": 2755.16, "end": 2755.94, "word": " تركيزه", "probability": 0.98779296875}, {"start": 2755.94, "end": 2757.02, "word": " للوضع", "probability": 0.9774169921875}, {"start": 2757.02, "end": 2758.06, "word": " الطبيعي،", "probability": 0.883837890625}, {"start": 2758.06, "end": 2758.7, "word": " تمام؟", "probability": 0.9723307291666666}], "temperature": 1.0}, {"id": 127, "seek": 277475, "start": 2759.79, "end": 2774.75, "text": "إذا هو نوعا ما بنقدر نحكي عنه هذا الـ Isoenzyme متخصص لعضلة القلب ومن خلاله أنا بتابع المريض هل في عنده acute myocardial infarction or not، تمام؟", "tokens": [28814, 15730, 31439, 8717, 45367, 995, 19446, 44945, 28543, 2288, 8717, 5016, 4117, 1829, 18871, 3224, 23758, 2423, 39184, 286, 539, 268, 1229, 1398, 44650, 9778, 9381, 9381, 5296, 3615, 11242, 37977, 25062, 46152, 4032, 27842, 16490, 1211, 6027, 3224, 41850, 39894, 16758, 3615, 9673, 16572, 11242, 8032, 1211, 8978, 43242, 3224, 24390, 452, 905, 515, 831, 1536, 289, 882, 420, 406, 12399, 46811, 10943, 22807], "avg_logprob": -0.13677705757653535, "compression_ratio": 1.2857142857142858, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2759.79, "end": 2760.17, "word": "إذا", "probability": 0.537841796875}, {"start": 2760.17, "end": 2760.59, "word": " هو", "probability": 0.9482421875}, {"start": 2760.59, "end": 2761.37, "word": " نوعا", "probability": 0.8260091145833334}, {"start": 2761.37, "end": 2761.51, "word": " ما", "probability": 0.9306640625}, {"start": 2761.51, "end": 2762.09, "word": " بنقدر", "probability": 0.89990234375}, {"start": 2762.09, "end": 2762.53, "word": " نحكي", "probability": 0.986572265625}, {"start": 2762.53, "end": 2762.89, "word": " عنه", "probability": 0.989501953125}, {"start": 2762.89, "end": 2763.37, "word": " هذا", "probability": 0.60693359375}, {"start": 2763.37, "end": 2763.65, "word": " الـ", "probability": 0.96728515625}, {"start": 2763.65, "end": 2764.51, "word": " Isoenzyme", "probability": 0.78779296875}, {"start": 2764.51, "end": 2765.59, "word": " متخصص", "probability": 0.981201171875}, {"start": 2765.59, "end": 2766.39, "word": " لعضلة", "probability": 0.81414794921875}, {"start": 2766.39, "end": 2767.05, "word": " القلب", "probability": 0.9951171875}, {"start": 2767.05, "end": 2767.61, "word": " ومن", "probability": 0.87744140625}, {"start": 2767.61, "end": 2768.21, "word": " خلاله", "probability": 0.995361328125}, {"start": 2768.21, "end": 2768.45, "word": " أنا", "probability": 0.8994140625}, {"start": 2768.45, "end": 2769.03, "word": " بتابع", "probability": 0.94580078125}, {"start": 2769.03, "end": 2769.57, "word": " المريض", "probability": 0.9876302083333334}, {"start": 2769.57, "end": 2770.05, "word": " هل", "probability": 0.897216796875}, {"start": 2770.05, "end": 2770.15, "word": " في", "probability": 0.95947265625}, {"start": 2770.15, "end": 2770.51, "word": " عنده", "probability": 0.9814453125}, {"start": 2770.51, "end": 2771.07, "word": " acute", "probability": 0.48486328125}, {"start": 2771.07, "end": 2771.99, "word": " myocardial", "probability": 0.978515625}, {"start": 2771.99, "end": 2772.85, "word": " infarction", "probability": 0.943359375}, {"start": 2772.85, "end": 2773.39, "word": " or", "probability": 0.77392578125}, {"start": 2773.39, "end": 2774.13, "word": " not،", "probability": 0.7054443359375}, {"start": 2774.13, "end": 2774.75, "word": " تمام؟", "probability": 0.978515625}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2775.5044375, "duration_after_vad": 2735.2281249999933}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/GYOlLisgDhg.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/GYOlLisgDhg.srt
new file mode 100644
index 0000000000000000000000000000000000000000..8ad488d1f725c4d42c723544601a3ae136fefad6
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/GYOlLisgDhg.srt
@@ -0,0 +1,1397 @@
+1
+00:00:00,940 --> 00:00:04,260
+السلام عليكم ورحمة الله وبركاته، يعطيكم العافية
+
+2
+00:00:04,260 --> 00:00:08,320
+جميعًا إن شاء الله، اليوم محاضرتنا بعنوان: liver
+
+3
+00:00:08,320 --> 00:00:15,060
+function test، فحوصات تشيك على وضع الكبد، هذه ال
+
+4
+00:00:15,060 --> 00:00:19,940
+slide اللي أمامنا، بنشوف فيها صور، هذه الصور عليها
+
+5
+00:00:19,940 --> 00:00:24,920
+شرح شريحها سيكون إن شاء الله في الـ slides القادمة
+
+6
+00:00:27,080 --> 00:00:31,160
+Liver is the largest organ of the body, weighing
+
+7
+00:00:31,160 --> 00:00:36,620
+about واحد ونصف كيلوغرام، يعتبر الكبد هو أكبر عضو
+
+8
+00:00:36,620 --> 00:00:42,580
+موجود في جسم الإنسان، ويزن حوالي واحد ونصف كيلو
+
+9
+00:00:42,580 --> 00:00:47,960
+غرام، ووزن العضو نفسه واحد ونصف كيلوغرام، فهو أكبر
+
+10
+00:00:47,960 --> 00:00:51,910
+عضو في جسم الإنسان. Liver is called the kitchen of our
+
+11
+00:00:51,910 --> 00:00:58,370
+body، يعتبر الكبد هو المطبخ في الجسم نظرًا، يعني
+
+12
+00:00:58,370 --> 00:01:02,990
+لأهميته في داخل الجسم، هو من أكبر الأعضاء، وزنه
+
+13
+00:01:02,990 --> 00:01:07,570
+حوالي واحد ونصف كيلوغرام، ويُطلق عليه مصطلح الـ
+
+14
+00:01:07,570 --> 00:01:11,450
+kitchen في الجسم، هو المطبخ داخل الجسم
+
+15
+00:01:21,940 --> 00:01:26,240
+Major metabolic functions of the liver، بدنا نستعرض
+
+16
+00:01:26,240 --> 00:01:31,860
+بهذه الـ slide أهم وظائف الكبد، هذه جزء من الوظائف
+
+17
+00:01:31,860 --> 00:01:37,300
+الوظائف كثيرة، ولكن هذه الوظائف يعني الأهم، تمام؟
+
+18
+00:01:37,620 --> 00:01:42,260
+والأساسية، أولًا: Synthetic Function، الكبد له
+
+19
+00:01:42,260 --> 00:01:47,760
+وظائف تصنيعية، اتفقنا أن الكبد داخل الجسم هو المصنع
+
+20
+00:01:47,760 --> 00:01:53,160
+الذي يصنع معظم بروتينات الجسم، الـ Plasma proteins،
+
+21
+00:01:53,160 --> 00:01:56,300
+البروتينات الموجودة في البلازما، الـ Albumin،
+
+22
+00:01:56,300 --> 00:02:00,800
+الـ Globulins، كلها، الـ Alpha 1، الـ Alpha 2، الـ Beta
+
+23
+00:02:00,800 --> 00:02:05,920
+هذه كل الـ Globulins، كلها هذه تُصنع من خلال الكبد
+
+24
+00:02:06,540 --> 00:02:10,080
+أيضًا الكوليسترول و الـ Triglyceride، حكينا أيضًا
+
+25
+00:02:10,080 --> 00:02:15,000
+الكبد مسؤول عن تصنيعهما، وأيضًا نحصل عليهما من الأكل
+
+26
+00:02:15,000 --> 00:02:20,160
+صح ولا لأ؟ and Lipoproteins، أيضًا ناقلات الدهون يا
+
+27
+00:02:20,160 --> 00:02:25,660
+جماعة، التي حكينا عنها، الـ HDL والـ LDL والـ VLDL،
+
+28
+00:02:25,660 --> 00:02:30,480
+هذه كلها الناقلات، أيضًا المسؤول عن تصنيعها هو الكبد،
+
+29
+00:02:30,480 --> 00:02:35,880
+إذًا الوظائف تصنيعية، الوظيفة الثانية: Detoxification
+
+30
+00:02:35,880 --> 00:02:41,280
+and Excretion، أيضًا للكبد وظائف، وهذه وظيفة كثيرًا
+
+31
+00:02:41,280 --> 00:02:47,580
+مهمة، إنه يتخلص من سمية بعض المواد التي تدخل
+
+32
+00:02:47,580 --> 00:02:52,660
+الجسم، كيف الكبد يتخلص من سمية المواد؟ أن الكبد
+
+33
+00:02:52,660 --> 00:02:57,760
+مسؤول عن تحويل الأمونيا إلى يوريا، وهذا اتفقنا عليه
+
+34
+00:02:57,760 --> 00:03:02,610
+في المحاضرة الماضية، نتيجة تكسير الـ Amino Acid،
+
+35
+00:03:02,610 --> 00:03:06,610
+الأحماض الأمينية، تنتج في الدم أمونيا، الأمونيا
+
+36
+00:03:06,610 --> 00:03:12,630
+سامة، تذهب الأمونيا إلى الكبد، لأن في الكبد سيتم
+
+37
+00:03:12,630 --> 00:03:17,590
+ربط الأمونيا بالـ CO2 وتحويل المركب إلى يوريا،
+
+38
+00:03:17,590 --> 00:03:22,710
+يعني الأمونيا تتحول إلى يوريا أين؟ في الكبد، وبعد ذلك
+
+39
+00:03:22,710 --> 00:03:27,050
+الـ Urea يُصار إلى إخراجها وطردها مع الـ Urine،
+
+40
+00:03:27,050 --> 00:03:34,050
+خارج الجسم، تمام؟ أيضًا يا جماعة الكبد مسؤول عن
+
+41
+00:03:34,050 --> 00:03:39,650
+التخلص من سمية الـ Bilirubin، الـ Bilirubin له مُعامل
+
+42
+00:03:39,650 --> 00:03:43,930
+خاص به، الأسبوع القادم سنأخذه، الـ Bilirubin عبارة عن
+
+43
+00:03:43,930 --> 00:03:49,490
+مادة كيميائية تنتج نتيجة تكسير الـ Hemoglobin الذي
+
+44
+00:03:49,490 --> 00:03:53,170
+موجود في الـ RBCs، التي هي الـ RBCs، خلايا الدم الحمراء،
+
+45
+00:03:53,170 --> 00:03:58,610
+عندما تتكسر؟ والـ Hemoglobin الذي بداخلها سيتكسر، فيصبح
+
+46
+00:03:58,610 --> 00:04:02,470
+عندنا Release لمادة الـ Bilirubin، أيضًا مادة الـ
+
+47
+00:04:02,470 --> 00:04:06,510
+Bilirubin مادة سامة، لو بقيت في الدم بتركيز عال،
+
+48
+00:04:06,510 --> 00:04:11,290
+يُعتبر سامًا، فالـ Bilirubin الذي يخرج من الـ RBCs
+
+49
+00:04:11,290 --> 00:04:16,850
+المكسرة، أين يذهب؟ أيضًا يذهب إلى الكبد، وفي الكبد
+
+50
+00:04:16,850 --> 00:04:23,370
+يُتم تحويله إلى مركب آخر أقل سمية، وهذا المركب الأقل
+
+51
+00:04:23,370 --> 00:04:29,350
+سمية بعد ذلك يصبح له Excretion، خروج من الجسم،
+
+52
+00:04:29,350 --> 00:04:34,870
+تمامًا، أيضًا الكوليسترول، اتفقنا عندما يكون الـ HDL، هذا
+
+53
+00:04:34,870 --> 00:04:39,250
+الـ Good Cholesterol، الذي يجمع الفائض عن حاجة
+
+54
+00:04:39,250 --> 00:04:43,170
+الخلايا، ويرجع، أين حكينا يوديه؟ يوديه إلى الكبد،
+
+55
+00:04:43,170 --> 00:04:49,110
+والكبد لديه ميكانيزم معين، يتخلص من الكوليسترول، إذًا
+
+56
+00:04:49,110 --> 00:04:54,120
+يعمل Detoxification، يتخلص من سمية المواد، Drug
+
+57
+00:04:54,120 --> 00:04:58,900
+Metabolism، أيضًا يا جماعة، عندما نتناول الأدوية، الأدوية
+
+58
+00:04:58,900 --> 00:05:04,400
+عندما نتناولها داخل الجسم، بميكانيزم معين الدواء يُحول
+
+59
+00:05:04,400 --> 00:05:10,190
+إلى مركب، ثم يُحول إلى مركب آخر، خلال تحويل الدواء من
+
+60
+00:05:10,190 --> 00:05:14,370
+مركب إلى مركب، ممكن يتكون مركب له سمية عالية،
+
+61
+00:05:14,370 --> 00:05:19,510
+من يتخلص من سمية هذا المركب؟ الكبد، الـ Storage
+
+62
+00:05:19,510 --> 00:05:24,030
+Function، الذي هو وظائف تخزينية، في الكبد يتم تخزين
+
+63
+00:05:24,030 --> 00:05:28,830
+أنواع كثيرة من الـ Vitamins، Vitamin A و D و E و K،
+
+64
+00:05:28,830 --> 00:05:33,110
+و Vitamin B12، أيضًا الكبد مسؤول عن تصنيع العصارة
+
+65
+00:05:33,110 --> 00:05:36,230
+الصفراوية، الـ Bile Acid أو ما تُسمى بالـ Bile Salt،
+
+66
+00:05:36,400 --> 00:05:40,540
+التي هذه العصارة الصفراوية تلعب دورًا مهمًا في أنها
+
+67
+00:05:40,540 --> 00:05:45,800
+تساعد في هضم الطعام، وخاصة في هضم الدهون، تمام؟
+
+68
+00:05:45,800 --> 00:05:49,960
+إذًا هذه الوظائف الأساسية للكبد في الجسم
+
+69
+00:05:55,420 --> 00:06:00,700
+Liver function tests، الفحوصات التي تشيك على وظائف
+
+70
+00:06:00,700 --> 00:06:05,240
+الكبد، هذه الفحوصات تُعد non-invasive methods،
+
+71
+00:06:05,240 --> 00:06:09,420
+for screening of liver dysfunction، هذه الفحوصات
+
+72
+00:06:09,420 --> 00:06:14,870
+non-invasive، يعني invasive معناها اختراق، فعليًا يا
+
+73
+00:06:14,870 --> 00:06:18,770
+جماعة، هو في الـ slide كاتب non-invasive، ولكن نحن
+
+74
+00:06:18,770 --> 00:06:24,430
+نحكي الطريقة invasive، يعني ندخل الـ needle،
+
+75
+00:06:24,430 --> 00:06:27,490
+في الوريد، صح ولا مش صح؟ أنا عندما أريد أن آخذ عينة الدم، كيف
+
+76
+00:06:27,490 --> 00:06:32,430
+أحصل على الدم لأعمل الفحوصات؟ لا أدخل الـ needle،
+
+77
+00:06:32,430 --> 00:06:38,200
+في الوريد لسحب الدم، فالطريقة invasive، تمام؟ ليست
+
+78
+00:06:38,200 --> 00:06:43,760
+نقطة خلاف، المهم أننا نسحب عينة الدم، ونعمل لها
+
+79
+00:06:43,760 --> 00:06:49,280
+الفحوصات التي تشيك على الكبد، لنرى هل الكبد
+
+80
+00:06:49,280 --> 00:06:55,140
+يؤدي وظيفته أم يوجد disorder، مشاكل، تمام؟ فجملة
+
+81
+00:06:55,140 --> 00:06:59,300
+invasive و non-invasive ليست نقطة خلاف، help in
+
+82
+00:06:59,300 --> 00:07:04,500
+identifying general types of disorder، هذه الفحوصات
+
+83
+00:07:04,500 --> 00:07:09,920
+تساعدني في تحديد أي نوع من الـ disease الموجود في
+
+84
+00:07:09,920 --> 00:07:15,780
+الكبد، يعني من خلال الفحوصات، أعرف وأستطيع أن أعرف ماذا
+
+85
+00:07:15,780 --> 00:07:20,430
+نوع الـ problem الموجودة في الكبد، تمام؟ أيضًا من
+
+86
+00:07:20,430 --> 00:07:24,990
+خلال الفحوصات، أستطيع أن assess severity and allow
+
+87
+00:07:24,990 --> 00:07:30,070
+prediction of outcome، أستطيع أن أُقيّم شدة المرض، يعني
+
+88
+00:07:30,070 --> 00:07:33,490
+من خلال نتيجة الفحص، أستطيع أن أقول: والله هذا المريض
+
+89
+00:07:33,490 --> 00:07:37,990
+الكبد لديه متضرر، هذا المريض لازال في بداية، لديه الكبد
+
+90
+00:07:37,990 --> 00:07:44,390
+فيه مشاكل، ممكن أن نُعالجه بالعلاج، وهكذا، تمام؟ أيضًا من
+
+91
+00:07:44,390 --> 00:07:50,050
+خلال الفحوصات، أستطيع أن أتوقع الـ Disease نفسه، أعمل
+
+92
+00:07:50,050 --> 00:07:53,790
+متابعة للمرض، ومتابعة للـ treatment، الناس الذين يكون
+
+93
+00:07:53,790 --> 00:07:58,090
+لديهم مشاكل في الكبد، يُعطون أنواعًا من العلاج، لكي
+
+94
+00:07:58,090 --> 00:08:04,320
+أعرف هل العلاج يُفيد، يعني يُحسّن المريض مع
+
+95
+00:08:04,320 --> 00:08:07,980
+العلاج أم لا؟ لا أستطيع أن أعرف إلا من خلال Liver
+
+96
+00:08:07,980 --> 00:08:11,480
+function test، من خلال الفحوصات التي تشيك على
+
+97
+00:08:11,480 --> 00:08:18,220
+الكبد، تمام؟ فهذه يعني وصف للفحوصات، أهمية الفحوصات،
+
+98
+00:08:18,220 --> 00:08:23,680
+أن لماذا نعمل فحوصات تشيك على وضع الكبد؟
+
+99
+00:08:27,080 --> 00:08:32,460
+Liver Function Test، فحوصات تشيك على وظائف الكبد،
+
+100
+00:08:32,460 --> 00:08:37,160
+بُصنّفت على أنها، هذه الفحوصات التي تشيك على
+
+101
+00:08:37,160 --> 00:08:42,080
+وظائف الكبد، قُسمت إلى قسمين، tests to detect
+
+102
+00:08:42,080 --> 00:08:47,540
+hepatic injury، مجموعة من الفحوصات تشيك لي على، و
+
+103
+00:08:47,540 --> 00:08:52,500
+تُكشف لي عن الـ hepatic injury، هل حدث فيه دمار في
+
+104
+00:08:52,500 --> 00:08:57,110
+الكبد؟ ومن خلال هذه الفحوصات، أستطيع أن أعرف هل
+
+105
+00:08:57,110 --> 00:09:01,650
+المريض لديه المشكلة mild or severe، المشكلة بسيطة
+
+106
+00:09:01,650 --> 00:09:07,930
+أم يعني شديدة، والأمور لديه يعني صعبة، أيضًا أستطيع
+
+107
+00:09:07,930 --> 00:09:12,510
+أن أُحدد هل المريض لديه المشكلة acute حادة أو chronic،
+
+108
+00:09:12,510 --> 00:09:18,040
+لديه مشاكل مزمنة في الكبد، أيضًا من خلال الفحوصات
+
+109
+00:09:18,040 --> 00:09:22,540
+أستطيع أن أُحدد طبيعة الإصابة التي أصيب بها الكبد، الـ
+
+110
+00:09:22,540 --> 00:09:28,660
+nature of liver injury، هل المشكلة hepatocellular
+
+111
+00:09:28,660 --> 00:09:33,160
+or cholestasis، هل المشكلة hepatocellular، يعني
+
+112
+00:09:33,160 --> 00:09:38,780
+المشكلة في خلايا الكبد نفسها؟ هل الإصابة أثرت على
+
+113
+00:09:38,780 --> 00:09:44,080
+خلايا الكبد نفسها، أو Cholestasis، Cholestasis هي الـ
+
+114
+00:09:44,080 --> 00:09:48,940
+stones، هي الحصوات، أو تكونت عند حصوات في الكبد،
+
+115
+00:09:48,940 --> 00:09:53,880
+وبالتالي، ممكن أن تعمل مشاكل في الكبد، أو ممكن يا جماعة
+
+116
+00:09:53,880 --> 00:09:58,860
+الحصوات تتكون في الـ Biliary Duct، في القناة
+
+117
+00:09:58,860 --> 00:10:03,060
+الصفراوية، التي هي ما بعد الكبد، تتكون بعد الكبد،
+
+118
+00:10:03,060 --> 00:10:08,720
+تمام؟ إذًا الكوليستاس، الحصوات إما في الكبد نفسه أو
+
+119
+00:10:08,720 --> 00:10:13,380
+في الـ Biliary duct، في القناة الصفراوية، طبعًا كل هذا
+
+120
+00:10:13,380 --> 00:10:19,740
+سيؤثر على الكبد، تمام؟  الجانب الآخر من الفحوصات،
+
+121
+00:10:19,740 --> 00:10:23,660
+لديّ مجموعة من الفحوصات تشيك على الـ Hepatic
+
+122
+00:10:23,660 --> 00:10:29,780
+function، على وظائف الكبد، مثلًا الوظيفة التصنيعية،
+
+123
+00:10:29,780 --> 00:10:33,180
+يعني أنا لابد أن يكون لديّ فحوصات تشيك على وظيفة
+
+124
+00:10:33,180 --> 00:10:37,280
+الكبد، من هذه الوظائف التصنيع، يعني أنا لابد أن يكون
+
+125
+00:10:37,280 --> 00:10:42,460
+لديّ فحص يقول لي: هل الكبد يصنع بروتينات جيدًا أم
+
+126
+00:10:42,460 --> 00:10:47,780
+الكبد فيه مشكلة، وبالتالي هذه المشكلة أثرت على
+
+127
+00:10:47,780 --> 00:10:54,200
+وظيفة التصنيع لديه، تمام؟ إذًا فحوصات تشيك على خلايا
+
+128
+00:10:54,200 --> 00:10:59,860
+الكبد نفسها، والحصوات، وفحوصات تشيك على وظائف الكبد،
+
+129
+00:10:59,860 --> 00:11:03,060
+مثلًا الوظيفة التصنيعية،
+
+130
+00:11:04,960 --> 00:11:10,440
+الـ Classification of liver function tests، هنا قسّمنا
+
+131
+00:11:10,440 --> 00:11:14,920
+الفحوصات التي تشيك على وظائف الكبد إلى ثلاث،
+
+132
+00:11:14,920 --> 00:11:18,680
+أقسام، إلى ثلاث مجموعات، مجموعة أولى، مجموعة ثانية، مجموعة
+
+133
+00:11:18,680 --> 00:11:23,580
+ثالثة، المجموعة الأولى: Markers of liver dysfunction،
+
+134
+00:11:23,580 --> 00:11:29,620
+المجموعة الأولى، فحوصات تشيك على وظائف الكبد، الـ Liver
+
+135
+00:11:29,620 --> 00:11:35,960
+function، هل الكبد يؤدي الوظائف التصنيعية الخاصة به أم
+
+136
+00:11:35,960 --> 00:11:40,480
+الوظيفة الـ Detoxification، التخلص من سمية بعض المواد
+
+137
+00:11:40,480 --> 00:11:45,260
+بالشكل الصحيح أم لا؟ هذه الـ slide إن شاء الله،
+
+138
+00:11:45,260 --> 00:11:51,660
+ستكون موضوعنا الأسبوع القادم، تمام؟ التي هي أننا
+
+139
+00:11:51,660 --> 00:11:57,240
+بدنا ندرس الفحوصات التي تشيك على وظائف الكبد، أولًا،
+
+140
+00:11:57,240 --> 00:12:03,520
+فحص الـ Serum Bilirubin، نفحص الـ Total Bilirubin و
+
+141
+00:12:03,520 --> 00:12:07,480
+الـ Conjugated Bilirubin، هذه أسماء فحوصات، Total
+
+142
+00:12:07,480 --> 00:12:12,840
+Bilirubin و Conjugated Bilirubin، سنشرحها، وسنتحدث
+
+143
+00:12:12,840 --> 00:12:16,130
+عن هذه الفحوصات الأسبوع القادم، اتفقنا أن الـ
+
+144
+00:12:16,130 --> 00:12:21,010
+Bilirubin يأتي من تكسير الـ RBCs، وهو مادة سامة، لابد أن
+
+145
+00:12:21,010 --> 00:12:24,890
+يذهب إلى الكبد، وفي الكبد يتحول إلى مادة أخرى، وبعد
+
+146
+00:12:24,890 --> 00:12:29,610
+ذلك، هذه المادة الأخرى، يُصار إلى إخراجها، تخرج خارج
+
+147
+00:12:29,610 --> 00:12:35,090
+الجسم، طيب لو الكبد فيه مشكلة، معناه لن يستطيع أن يؤدي
+
+148
+00:12:35,090 --> 00:12:39,670
+وظيفة الـ Detoxification، معناه لن يستطيع أن يتخلص من
+
+149
+00:12:39,670 --> 00:12:44,610
+الـ Bilirubin، وبالتالي سيكون لدينا مشكلة في جسم
+
+150
+00:12:44,610 --> 00:12:49,570
+الإنسان، تمام؟ إذًا نفحص الـ Total و الـ Conjugated
+
+151
+00:12:49,570 --> 00:12:54,510
+Bilirubin، يشيكان على وظيفة الكبد، أي وظيفة؟
+
+152
+00:12:54,510 --> 00:13:00,350
+وظيفة الـ Detoxification، التخلص من السمية، تمام؟
+
+153
+00:13:00,350 --> 00:13:05,810
+أيضًا، ممكن أن آخذ عينة Urine، وأفحص فيها الـ Bile
+
+154
+00:13:05,810 --> 00:13:10,410
+Salt، العصارة الصفراوية، و الـ Urobilinogen، الـ
+
+155
+00:13:10,410 --> 00:13:14,550
+Urobilinogen هذه مادة تأتي من الـ Bilirubin،
+
+156
+00:13:14,550 --> 00:13:18,870
+ممكن أن أخذتوها في المحاضرات السابقة، وحتى لو لم تأخذوها الأسبوع
+
+157
+00:13:18,870 --> 00:13:21,930
+الذي يأتي، سنشرح بالضبط من أين تأتي، ولكن سريعًا،
+
+158
+00:13:21,930 --> 00:13:25,710
+الـ Urobilinogen هذه مادة تأتي من الـ Bilirubin،
+
+159
+00:13:25,710 --> 00:13:30,640
+تمام؟ فأنا لو فحصت هذه المادة في الـ Urine،
+
+160
+00:13:30,640 --> 00:13:37,260
+وفحصت العصارة الصفراوية، أستطيع أيضًا أن أُقيّم هل الكبد
+
+161
+00:13:37,260 --> 00:13:43,060
+يؤدي وظيفته أم لا، تمام؟ هل الكبد ينتج Bile
+
+162
+00:13:43,060 --> 00:13:47,320
+Salt أم لا؟ إذًا أنا هنا أشيك على الوظيفة
+
+163
+00:13:47,320 --> 00:13:53,530
+التصنيعية للكبد، تمام؟ أنه ينتج Bile Salt أم لا،
+
+164
+00:13:53,530 --> 00:13:58,790
+أيضًا لو أنا عملت فحص الـ Total Protein، وفحص
+
+165
+00:13:58,790 --> 00:14:04,490
+الألبومين، وفحص آخر يُسمى Albumin to Globulin
+
+166
+00:14:04,490 --> 00:14:08,950
+Ratio، أنا هكذا أيضًا أشيك على الوظيفة التصنيعية
+
+167
+00:14:08,950 --> 00:14:13,190
+للَكبد، لأنه لو طلع الـ Total Bilirubin، قيم منخفضة جدًا عند
+
+168
+00:14:13,190 --> 00:14:19,200
+المريض، آسف، الـ Total Protein، لو طلعت تركيز
+
+169
+00:14:19,200 --> 00:14:23,560
+البروتينات في الجسم منخفضة جدًا، أفهم أن الكبد تصنيعه
+
+170
+00:14:23,560 --> 00:14:28
+
+223
+00:19:00,700 --> 00:19:04,760
+significance are هذه العائلة الكبيرة حكينا تضم
+
+224
+00:19:04,760 --> 00:19:09,740
+مجموعة من الإنزيمات أهم two enzymes في العائلة هما
+
+225
+00:19:09,740 --> 00:19:15,740
+الـ AST والـ ALT هذه الفحوصات أو هذه الإنزيمات لها
+
+226
+00:19:15,740 --> 00:19:20,460
+وظائف تشخيصية من خلالها أنا بقدر أشيك على خلايا
+
+227
+00:19:20,460 --> 00:19:27,590
+الكبد، حدث فيها injury أو سليمة. إذن أول إنزيم مهم
+
+228
+00:19:27,590 --> 00:19:33,850
+الـ AST اسمه Aspartate Aminotransferase. اسم آخر
+
+229
+00:19:33,850 --> 00:19:40,690
+للإنزيم Glutamate Oxaloacetate Transaminase أو
+
+230
+00:19:40,690 --> 00:19:46,670
+بيحكوا عنه الـ GOT. إذن الاختصارات مهمة، اسم الإنزيم
+
+231
+00:19:46,670 --> 00:19:53,990
+AST أو GOT تمام، إلى اسمين. الإنزيم الآخر الـ ALT
+
+232
+00:19:53,990 --> 00:19:58,890
+اختصاره Alanine Aminotransferase، الاسم الآخر
+
+233
+00:19:58,890 --> 00:20:04,370
+للإنزيم Glutamate Pyruvate Transaminase أو
+
+234
+00:20:04,370 --> 00:20:11,320
+الاختصار GPT. الـ AST بيحكوا عنه الـ GOT والـ ALT
+
+235
+00:20:11,320 --> 00:20:16,360
+بيحكوا عنه الـ GPT. هذه أسماء أخرى للإنزيمات. الـ
+
+236
+00:20:16,360 --> 00:20:22,260
+Pyridoxal Phosphate أو بيسموه الـ B6. هذا يعتبر
+
+237
+00:20:22,260 --> 00:20:28,380
+الـ core enzyme أو الـ core factor. هذا يعتبر هو
+
+238
+00:20:28,380 --> 00:20:34,080
+اللي بينشط الإنزيمات الـ AST والـ ALT أو العائلة
+
+239
+00:20:34,080 --> 00:20:39,400
+كلها، يعني الإنزيمات. إنزيمات الـ Amino Transferase
+
+240
+00:20:39,400 --> 00:20:44,180
+إنزيمات هذه العائلة عشان تشتغل يا جماعة بدها محفز،
+
+241
+00:20:44,180 --> 00:20:48,580
+بدها Co-Factor، بدها Co-Enzyme. الـ Co-Enzyme لهذه
+
+242
+00:20:48,580 --> 00:20:54,600
+العائلة هو مادة الـ Pyridoxal Phosphate، تمام؟ من
+
+243
+00:20:54,600 --> 00:21:02,640
+غيره، الإنزيمات ما بتشتغل وما بتأدي وظيفتها. نبدأ إن
+
+244
+00:21:02,640 --> 00:21:06,780
+شاء الله بالفحوصات اللي بتشيك على الـ
+
+245
+00:21:06,780 --> 00:21:11,720
+Hepatocellular injury على خلايا الكبد نفسها. حكينا
+
+246
+00:21:11,720 --> 00:21:17,940
+two enzymes الـ AST والـ ALT، ونبدأ بأول enzyme الـ
+
+247
+00:21:17,940 --> 00:21:24,790
+AST test، فحص الـ AST Aspartate Aminotransferase.
+
+248
+00:21:24,790 --> 00:21:29,830
+الـ AST involved in the transfer of amino group
+
+249
+00:21:29,830 --> 00:21:37,160
+between الاسبارتات and الألفا كيتو جلوطاريت. بحكي لي هنا إن
+
+250
+00:21:37,160 --> 00:21:41,880
+الـ AST، إيش الوظيفة الأساسية له هذا الـ enzyme؟
+
+251
+00:21:41,880 --> 00:21:50,940
+ينقل amino group من مركب الاسبارتات لمركب الـ
+
+252
+00:21:50,940 --> 00:21:57,040
+Alpha-Ketoglutarate. لو جيت على الرسمة هي
+
+253
+00:21:57,040 --> 00:22:01,820
+الاسبارتات، مادة الاسبارتات ترتبط مع مادة الـ Alpha
+
+254
+00:22:01,820 --> 00:22:09,140
+Ketoglutarate في وجود إنزيم الـ AST، الـ Aspartate
+
+255
+00:22:09,140 --> 00:22:15,420
+هيتم، هذا الـ enzyme، الـ AST، هينقل amino group من
+
+256
+00:22:15,420 --> 00:22:21,280
+مادة الـ Aspartate لمادة الـ Alpha-Keto جلوطاريت.
+
+257
+00:22:21,280 --> 00:22:27,020
+إيه المحصلة؟ الـ Aspartate هيتحول لـ Oxaloacetate،
+
+258
+00:22:27,020 --> 00:22:33,100
+والـ Alpha-Keto جلوطاريت هتتحول لجلوتامات. يعني
+
+259
+00:22:33,100 --> 00:22:37,600
+نتيجة نقل amino group من الـ Aspartate للـ Alpha
+
+260
+00:22:37,600 --> 00:22:42,380
+Ketoglutarate، الـ Aspartate تتحول لـ Oxaloacetate،
+
+261
+00:22:42,380 --> 00:22:46,720
+والـ Alpha-Ketoglutarate اتحول لجلوتامات. يا
+
+262
+00:22:46,720 --> 00:22:51,340
+جماعة، التفاعل مش حفظ، ما بيعني أنه يتحفظ. أخذتوة في
+
+263
+00:22:51,340 --> 00:22:54,660
+الحيوية وأكيد فاهمينه وعارفينه، بس كنتوا تعرفوا أنه
+
+264
+00:22:54,660 --> 00:22:57,680
+بينقل Amino Group من الـ Aspartate للـ Alpha Keto
+
+265
+00:22:57,680 --> 00:23:04,550
+Gultarate. هذه الوظيفة الأساسية للـ AST، تمام؟ الـ
+
+266
+00:23:04,550 --> 00:23:09,250
+Clinical Significance يعني الأهمية الطبية لهذا
+
+267
+00:23:09,250 --> 00:23:14,830
+الفحص، لفحص الـ AST. الـ AST، الـ Aspartate Amino
+
+268
+00:23:14,830 --> 00:23:19,230
+Transferase is an enzyme found primarily in the
+
+269
+00:23:19,230 --> 00:23:23,150
+heart, liver and muscle. هذا الـ enzyme يا جماعة
+
+270
+00:23:23,150 --> 00:23:30,190
+بشكل أساسي موجود في القلب، وموجود جوا الكبد، وموجود
+
+271
+00:23:30,190 --> 00:23:35,250
+في الـ muscle، في العضلات، تمام؟ إذن بدنا نفهم إن
+
+272
+00:23:35,250 --> 00:23:40,350
+إنزيم الـ AST مكانه الأصلي موجود في عضلة القلب،
+
+273
+00:23:40,350 --> 00:23:45,410
+وموجود في الكبد، وموجود في العضلات. طب لو سألناكم
+
+274
+00:23:45,410 --> 00:23:51,010
+سؤال، الـ AST هذا الإنزيم موجود في الدم ولا لا؟
+
+275
+00:23:51,010 --> 00:23:55,870
+موجود في بلازما الدم ولا لا؟ هجاوبكم: صحيح موجود في
+
+276
+00:23:55,870 --> 00:24:01,440
+بلازما الدم، ولكن الـ Concentration قليل جدًا، يعني
+
+277
+00:24:01,440 --> 00:24:06,360
+موجود في البلازما تبعتنا، ولكن بتركيز قليل جدًا،
+
+278
+00:24:06,360 --> 00:24:10,860
+هذا الإنسان الطبيعي. إذا الإنسان الطبيعي لو فحصناه
+
+279
+00:24:10,860 --> 00:24:15,740
+الـ AST، لازم يكون الـ AST قليل جدًا، بلا
+
+280
+00:24:15,740 --> 00:24:21,000
+Concentration، موجود في بلازما الدم لأنه بشكل أساس
+
+281
+00:24:21,000 --> 00:24:24,960
+الـ AST ما بيكون موجود في الدم بكميات كبيرة، هو يَمتاز
+
+282
+00:24:24,960 --> 00:24:31,160
+بأنه موجود في الكبد، وفي عضلة القلب، وفي العضلات الأخرى.
+
+283
+00:24:31,160 --> 00:24:35,980
+تمام؟ Additional AST is released into the
+
+284
+00:24:35,980 --> 00:24:40,700
+circulation after injury or death of cells. تخيلوا
+
+285
+00:24:40,700 --> 00:24:46,560
+معي، الخلايا الكبد بدأت يصير فيها damage، بدأت يصير
+
+286
+00:24:46,560 --> 00:24:51,820
+فيها تدمير. إيش هيصير لما خلايا الكبد تتدمر؟ هيصير
+
+287
+00:24:51,820 --> 00:24:57,940
+في عندي release، تسرب، للـ Enzyme الـ AST من خلايا
+
+288
+00:24:57,940 --> 00:25:04,080
+الكبد إلى بلازما الدم. وبالتالي، لو جيت لإنسان
+
+289
+00:25:04,080 --> 00:25:08,600
+اللي عنده مشكلة في خلايا الكبد، عنده damage، وفحصت له
+
+290
+00:25:08,600 --> 00:25:13,980
+الـ AST، هلاقي تركيز الـ AST عنده في الدم عالي جدًا.
+
+291
+00:25:13,980 --> 00:25:18,810
+فلما ألاقي تركيز الـ AST في الدم عالي جدًا، بدنا نفهم
+
+292
+00:25:18,810 --> 00:25:24,830
+بسرعة إن هذا الشخص ممكن يكون صاير عنده مشكلة في
+
+293
+00:25:24,830 --> 00:25:29,110
+خلايا الكبد، وتدمير في خلايا الكبد، وبالتالي أدى ذلك
+
+294
+00:25:29,110 --> 00:25:34,390
+لخروج الـ enzyme من مكانه الأصلي من الكبد إلى
+
+295
+00:25:34,390 --> 00:25:41,220
+البلازما الدم. يعني الـ AST بيزيد في الدم بعد حدوث
+
+296
+00:25:41,220 --> 00:25:48,160
+death، موت للخلايا، أو إصابة لخلايا الكبد، أو خلايا
+
+297
+00:25:48,160 --> 00:25:54,380
+القلب أو العضلات نفسها، تمام؟ This test is one of
+
+298
+00:25:54,380 --> 00:25:57,880
+the several that are performed when there has been
+
+299
+00:25:57,880 --> 00:26:02,280
+damage to the heart muscle as in myocardial
+
+300
+00:26:02,280 --> 00:26:07,000
+infarction and in assessing liver damage. هذا الفحص
+
+301
+00:26:07,000 --> 00:26:12,560
+يا جماعة، يبين أيضًا، لو حسينا في عندنا مشكلة في
+
+302
+00:26:12,560 --> 00:26:18,800
+عضلة القلب، حدوث مثلًا تدمير في خلايا عضلة القلب. لما
+
+303
+00:26:18,800 --> 00:26:22,860
+يصير عندي مشكلة، دمج في القلب، مشكلة في القلب، وفي
+
+304
+00:26:22,860 --> 00:26:27,380
+خلايا القلب، برضه الـ AST الموجود في القلب، هيبقى
+
+305
+00:26:27,380 --> 00:26:31,840
+يطلع من القلب، ويروح وين؟ ويجي على الدم، وبالتالي
+
+306
+00:26:31,840 --> 00:26:36,100
+يزداد تركيزه في الدم. أيضًا في حالات الـ myocardial
+
+307
+00:26:36,100 --> 00:26:41,000
+infarction، النوبة القلبية. النوبة القلبية، برضه خلايا
+
+308
+00:26:41,000 --> 00:26:46,260
+القلب برضه بيصير فيها damage، برضه هيطلع الـ AST من
+
+309
+00:26:46,260 --> 00:26:51,660
+القلب للدم، وبالتالي يزيد تركيزه في الدم. أيضًا حالات
+
+310
+00:26:51,660 --> 00:26:56,920
+الـ liver damage. يعني يا جماعة، من هاي الـ slide بس
+
+311
+00:26:56,920 --> 00:27:02,280
+نتج أن فحص الـ AST فحص مش specific، زي اليوريا لما
+
+312
+00:27:02,280 --> 00:27:08,600
+حكينا عن اليوريا والـ kidney. إذن فحص الـ AST فحص مش
+
+313
+00:27:08,600 --> 00:27:15,100
+متخصص لمشاكل الكبد، ليش؟ لأن الـ AST موجود بأكثر من
+
+314
+00:27:15,100 --> 00:27:19,280
+مكان، موجود في الكبد، وفي القلب، وفي العضلات. فلما
+
+315
+00:27:19,280 --> 00:27:24,970
+يصير damage سواء في الكبد أو في القلب أو في العضلات
+
+316
+00:27:24,970 --> 00:27:30,930
+هيزيد تركيزه في الدم، فهو مش خاص بس لمشاكل
+
+317
+00:27:30,930 --> 00:27:35,990
+الكبد، برضه هو بيزيد في حالات مشاكل القلب ومشاكل
+
+318
+00:27:35,990 --> 00:27:41,660
+العضلات، تمام؟ okay، بنرجع نحكي إنه مش متخصص للكبد،
+
+319
+00:27:41,660 --> 00:27:46,640
+على الرغم من إنه مش متخصص، إلا إنه بيعتبر فحص من
+
+320
+00:27:46,640 --> 00:27:52,100
+الفحوصات اللي بتشيك على الكبد، تمام؟ Infants levels
+
+321
+00:27:52,100 --> 00:27:56,480
+approximately twice the adult level. بحكي، الأطفال
+
+322
+00:27:56,480 --> 00:28:03,240
+بيكون عندهم تركيز، يعني المواليد الجدد والأطفال بيكون
+
+323
+00:28:03,240 --> 00:28:08,240
+عندهم تركيز الـ enzyme الـ AST، أعلى من الـ
+
+324
+00:28:08,240 --> 00:28:13,480
+Adult بمرتين، تمام؟ بعد هيك، بيبدأ التركيز عندهم
+
+325
+00:28:13,480 --> 00:28:21,860
+يقل لحد ما يصل للتركيز اللي يفترض يكون موجود عند
+
+326
+00:28:21,860 --> 00:28:26,900
+الـ Adult، وهذا بيصير حوالي أول 6 شهور، يعني أول ما
+
+327
+00:28:26,900 --> 00:28:32,150
+ينولد الطفل، الجنين يعني الـ fetus نفسه، أول ما ينولد
+
+328
+00:28:32,150 --> 00:28:36,430
+الـ newborn، المواليد الجدد، أول ما ينولدوا بيكون
+
+329
+00:28:36,430 --> 00:28:41,870
+عندهم تركيز الـ AST أعلى من الـ Adult بمرتين. بعد
+
+330
+00:28:41,870 --> 00:28:46,590
+هيك لما بيصير عمره 6 شهور، الـ baby لما بيصير عمره 6
+
+331
+00:28:46,590 --> 00:28:52,010
+شهور، خلاص تركيز الـ AST بيصير عنده نفس تركيز الـ
+
+332
+00:28:52,010 --> 00:28:58,540
+AST اللي موجود عند الـ Adult، تمام؟ معلومة مش كتير
+
+333
+00:28:58,540 --> 00:29:04,280
+بنركز عليها، يعني أهم شيء نفهم الـ AST وين موجود،
+
+334
+00:29:04,280 --> 00:29:08,440
+وتركيزه في الدم بيكون قليل، تمام؟ في حال حدوث دمج
+
+335
+00:29:08,440 --> 00:29:12,300
+في الكبد أو في القلب أو في العضلات، هيطلع من هذه
+
+336
+00:29:12,300 --> 00:29:16,320
+الأماكن للدم، وبالتالي يزيد، وبالتالي هيزيد
+
+337
+00:29:16,320 --> 00:29:22,600
+تركيزه، بس هذا المهم في هذه الـ slide. الـ specimen
+
+338
+00:29:22,600 --> 00:29:26,300
+collection، يعني لما يجيني patient بدي أعمله فحص
+
+339
+00:29:26,300 --> 00:29:32,380
+الـ AST، شو العينة اللي بنستخدمها؟ Serum أو بلازما، و
+
+340
+00:29:32,380 --> 00:29:35,700
+لما بدي أجمع في بلازما، الـ anticoagulant المسموح
+
+341
+00:29:35,700 --> 00:29:40,700
+فيها إما EDTA أو Heparin، تمام؟ هي النقطة الأولى.
+
+342
+00:29:40,700 --> 00:29:44,200
+النقطة الثانية بدي إياكم تركزوا معها. هلا جينا اتفقنا
+
+343
+00:29:44,200 --> 00:29:49,640
+إن الـ AST موجود بشكل أساسي في الـ liver وفي الـ
+
+344
+00:29:49,640 --> 00:29:52,800
+heart، في الكبد والقلب والعضلات.
+
+345
+00:29:52,800 --> 00:29:58,460
+واضيفوا كمان موقع رابع للـ AST، أيضًا الـ AST موجود
+
+346
+00:29:58,460 --> 00:30:04,760
+جوا الـ RBCs، جوا خلايا الدم الحمراء، تمام؟ إذن الـ
+
+347
+00:30:04,760 --> 00:30:09,360
+AST موجود في الـ heart، والـ liver، والـ muscle، والـ
+
+348
+00:30:09,360 --> 00:30:15,240
+RBCs. وبالتالي يا جماعة، Hemolysis should be avoided
+
+349
+00:30:15,240 --> 00:30:20,100
+because it can dramatically increase الـ serum AST
+
+350
+00:30:20,100 --> 00:30:24,600
+concentration. أي عينة hemolyzed لازم أعملها
+
+351
+00:30:24,600 --> 00:30:28,720
+rejection. لما بدك تشتغلي فحص الـ AST، أي عينة
+
+352
+00:30:28,720 --> 00:30:33,340
+ فيها Hemolysis، يعني الـ RBCs فيها متكسرة، هذه
+
+353
+00:30:33,340 --> 00:30:38,640
+العينة ممنوع نستخدمها، ليش؟ لأن الـ Hemolysis بيؤدي
+
+354
+00:30:38,640 --> 00:30:43,780
+إلى تكسير الـ RBCs، بيؤدي إلى خروج الـ AST من
+
+355
+00:30:43,780 --> 00:30:49,160
+موقعه، من الـ RBCs إلى الـ serum، تمام؟ وبالتالي،
+
+356
+00:30:49,160 --> 00:30:54,180
+أنا باجي بفحص المريض، بلاقي عنده الـ AST عالي كثير
+
+357
+00:30:54,180 --> 00:30:59,720
+في الـ serum. طب هل هو عالي لإنه عنده مشكلة مرضية ولا
+
+358
+00:30:59,720 --> 00:31:05,840
+الـ AST عالي لإنه عندي خلل في جمع العينة، صار
+
+359
+00:31:05,840 --> 00:31:10,170
+Hemolysis، وبالتالي طلع الـ AST من الـ RBCs على الـ
+
+360
+00:31:10,170 --> 00:31:17,050
+serum وزود تركيزه بشكل خاطئ، تمام؟ إذن يا جماعة، الـ
+
+361
+00:31:17,050 --> 00:31:21,910
+AST موجود بشكل أساسي في الـ RBCs، فأثناء جمع العينة
+
+362
+00:31:21,910 --> 00:31:26,070
+بدي أتجنب الـ Hemolysis، لأنه بأخاف الـ RBCs تتكسر
+
+363
+00:31:26,070 --> 00:31:31,490
+ويطلع منها الـ AST ويطلع على الـ serum ويزيد تركيز
+
+364
+00:31:31,490 --> 00:31:37,760
+الـ AST بشكل خاطئ. معلومة، بحكيلكم الـ RBCs contain
+
+365
+00:31:37,760 --> 00:31:43,220
+خمس أضعاف الـ AST الموجود في الـ serum. الـ RBCs
+
+366
+00:31:43,220 --> 00:31:47,560
+بتحتوي على AST، هي الفكرة أن الـ RBCs بتحتوي على
+
+367
+00:31:47,560 --> 00:31:53,880
+AST بكميات كبيرة أكثر من الـ AST الموجود في
+
+368
+00:31:53,880 --> 00:31:55,720
+الـ serum، تمام؟
+
+369
+00:31:58,430 --> 00:32:02,330
+الـ "Assay for enzyme activity"، بدنا نشوف الطرق
+
+370
+00:32:02,330 --> 00:32:06,330
+المستخدمة لقياس نشاط الإنزيم في الـ serum. إحنا يا
+
+371
+00:32:06,330 --> 00:32:10,670
+جماعة ما بنقيس تركيز الإنزيم في الـ serum، إحنا
+
+372
+00:32:10,670 --> 00:32:14,810
+بنقيس مدى نشاط الإنزيم، الـ activity تبع الإنزيم،
+
+373
+00:32:14,810 --> 00:32:19,430
+ولما إحنا بنقيس الـ activity، الـ activity تعبر عن
+
+374
+00:32:19,430 --> 00:32:26,840
+تركيز الإنزيم، تمام؟ Measurement by Karmen method.
+
+375
+00:32:26,840 --> 00:32:31,520
+إحنا بنقيس الـ AST، بنقيس نشاطه في الـ serum بطريقة
+
+376
+00:32:31,520 --> 00:32:36,340
+الـ Karmen method، a coupled reaction involving
+
+377
+00:32:36,340 --> 00:32:40,060
+التفاعل لابد من وجود فيه الـ Pyridoxal 5-Phosphate،
+
+378
+00:32:40,060 --> 00:32:44,240
+هذا الـ cofactor اللي بينشط الإنزيم وبيخليه
+
+379
+00:32:44,240 --> 00:32:47,640
+يقدِّي وظيفته. لازم يكون فيه في التفاعل، ماليت
+
+380
+00:32:47,640 --> 00:32:52,650
+Dehydrogenase. هنشوف شو وظيفته. الـ reaction كله
+
+381
+00:32:52,650 --> 00:32:57,450
+هيكون على 37 درجة سليزيوس، يعني أنا فعليًا هشتغل
+
+382
+00:32:57,450 --> 00:33:01,470
+التفاعل على الـ water bath، مش على الـ room
+
+383
+00:33:01,470 --> 00:33:06,330
+temperature. في محصلة التفاعل، هنقرأ الـ decrease في
+
+384
+00:33:06,330 --> 00:33:09,610
+الـ absorbance، القلة في الـ absorbance على
+
+385
+00:33:09,610 --> 00:33:15,690
+wavelength 340. يعني هستخدم كيوفيت خاصة مصنوعة من
+
+386
+00:33:15,690 --> 00:33:20,550
+الزجاج، مش بلاستيك. كيوفيت لأن الـ wavelengths
+
+387
+00:33:20,550 --> 00:33:23,550
+340، يعني أنا بقرأ في منطقة الـ
+
+388
+00:33:23,550 --> 00:33:27,570
+ultraviolet، المنطقة فوق البنفسجية. الها كيوفيت
+
+389
+00:33:27,570 --> 00:33:32,650
+خاصة، تمام؟ هلا جينا للمربع الأزرق، هنحكي الـ
+
+390
+00:33:32,650 --> 00:33:37,610
+principle للفحص، مبدأ الفحص، كيف الفحص بيصير. هلا
+
+391
+00:33:37,6
+
+445
+00:38:07,610 --> 00:38:12,330
+اللي بيصير فيها ده مش في خلايا الكبد بشكل حاد يعني
+
+446
+00:38:12,330 --> 00:38:17,090
+إنسان سليم وما فيه شيء فجأة بيحكيلك عنده «acute
+
+447
+00:38:17,090 --> 00:38:22,150
+hepatocellular disorder» يعني حالة حادة بشكل مفاجئ
+
+448
+00:38:22,150 --> 00:38:27,510
+فبـتكون خلايا الكبد حدث فيها مشكلة، بيكون سبب الـ
+
+449
+00:38:27,510 --> 00:38:31,670
+Damage اللي صار في الكبد هو الـ Viral Hepatitis
+
+450
+00:38:31,670 --> 00:38:36,650
+فيروس دخل خلايا الكبد وعمل فيها التهابات وبالتالي
+
+451
+00:38:36,650 --> 00:38:40,410
+أحدث فيها Damage نتيجة هذا الـ Damage، الـ AST
+
+452
+00:38:40,410 --> 00:38:43,950
+بيطلع من خلايا الكبد إلى الدم وبالتالي يزداد
+
+453
+00:38:43,950 --> 00:38:48,670
+تركيزه. أيضًا حالات الـ Cirrhosis، حالات تليف الكبد
+
+454
+00:38:48,670 --> 00:38:54,650
+برضه هيطلع الـ AST من خلايا الكبد إلى الدم ويزيد
+
+455
+00:38:54,650 --> 00:38:56,040
+تركيزه. السلام عليكم
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/GYOlLisgDhg_postprocess.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/GYOlLisgDhg_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..f55255170dae8f258d9b671019a302372e23c250
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/GYOlLisgDhg_postprocess.srt
@@ -0,0 +1,1820 @@
+1
+00:00:00,940 --> 00:00:04,260
+السلام عليكم ورحمة الله وبركاته يعطيكم العافية
+
+2
+00:00:04,260 --> 00:00:08,320
+جميعا إن شاء الله اليوم محاضرتنا بعنوان liver
+
+3
+00:00:08,320 --> 00:00:15,060
+function test فحوصات تشيك على وضع الكبد هذه ال
+
+4
+00:00:15,060 --> 00:00:19,940
+slide اللي أمامنا بنشوف فيها صور هذه الصور عليها
+
+5
+00:00:19,940 --> 00:00:24,920
+شريح شريحها هيكون إن شاء الله في ال slides القادمة
+
+6
+00:00:27,080 --> 00:00:31,160
+Liver is the largest organ of the body weighing
+
+7
+00:00:31,160 --> 00:00:36,620
+about واحد و نص كيلو جرام يعتبر الكبت هو أكبر عضو
+
+8
+00:00:36,620 --> 00:00:42,580
+موجود في جسم الإنسان وبيوزن حوالي واحد و نص كيلو
+
+9
+00:00:42,580 --> 00:00:47,960
+جرام ووزن العضو نفسه واحد و نص كيلو جرام فهو أكبر
+
+10
+00:00:47,960 --> 00:00:51,910
+عضو في جسم الإنسانLiver is called kitchen of our
+
+11
+00:00:51,910 --> 00:00:58,370
+body بعتبره ال liver هو المطبخ في الجسم نظرا يعني
+
+12
+00:00:58,370 --> 00:01:02,990
+لأهميته في داخل الجسم هو من أكبر الأعضاء وزنه
+
+13
+00:01:02,990 --> 00:01:07,570
+حوالي واحد و نص كيلو جرام وبيطلق عليه مصطلح ال
+
+14
+00:01:07,570 --> 00:01:11,450
+kitchen في الجسم هو المطبخ داخل الجسم
+
+15
+00:01:21,940 --> 00:01:26,240
+Major metabolic functions of the liver بدنا نستعرض
+
+16
+00:01:26,240 --> 00:01:31,860
+بهاي ال slide أهم وظائف للكبد هذه جزء من الوظائف
+
+17
+00:01:31,860 --> 00:01:37,300
+الوظائف كتيرة بس هذه الوظائف يعني الأهم تمام؟
+
+18
+00:01:37,620 --> 00:01:42,260
+والأساسية أول شغلة Synthetic Function الكبد له
+
+19
+00:01:42,260 --> 00:01:47,760
+وظائف تصنيعية اتفجنا إن الكبد جوات الجسم هو المصنع
+
+20
+00:01:47,760 --> 00:01:53,160
+اللي بيصنع معظم بروتينات الجسم الـPlasma proteins
+
+21
+00:01:53,160 --> 00:01:56,300
+البروتينات الموجودة في البلازمة الـAlbumin
+
+22
+00:01:56,300 --> 00:02:00,800
+الـGlobulins كلها الـAlpha 1 الـAlpha 2 الـBeta
+
+23
+00:02:00,800 --> 00:02:05,920
+هذه كل الـGlobulins كلها هذه بتتصنع من خلال الكبد
+
+24
+00:02:06,540 --> 00:02:10,080
+أيضًا الكوليسترول و الـ triglyceride حكينا برضه
+
+25
+00:02:10,080 --> 00:02:15,000
+الكبد مسئول عن تصنيعهم و برضه بنحصل عليهم من الأكل
+
+26
+00:02:15,000 --> 00:02:20,160
+صح ولا لأ؟ and ليبوبروتينز برضه نواقل الدهون يا
+
+27
+00:02:20,160 --> 00:02:25,660
+جماعةاللي حكينا عنها الـ HDL والـ LDL والـ VLDL
+
+28
+00:02:25,660 --> 00:02:30,480
+هذه كلها النواقل برضه المسؤول عن تصنيعها هو الكبد،
+
+29
+00:02:30,480 --> 00:02:35,880
+اذا الوظائف تصنيعية الوظيفة التانية Detoxification
+
+30
+00:02:35,880 --> 00:02:41,280
+and Excretionبرضه إله وظائف الكبد وهذه وظيفة كتير
+
+31
+00:02:41,280 --> 00:02:47,580
+مهمة إنه بيتخلص من سمية بعض المواد اللي بتدخل
+
+32
+00:02:47,580 --> 00:02:52,660
+الجسم كيف الكبد بتخلص من سمية المواد؟ إن الكبد
+
+33
+00:02:52,660 --> 00:02:57,760
+مسئول عن تحويل الأمونيا إلى يوريا وهذا اتفجنا عليه
+
+34
+00:02:57,760 --> 00:03:02,610
+في المعمل اللي فاتمتيجة تكسير الـ Amino Acid
+
+35
+00:03:02,610 --> 00:03:06,610
+الأحماض الأمينية تنتج في الدم أمونيا الأمونيا
+
+36
+00:03:06,610 --> 00:03:12,630
+ثامنة بتروح الأمونيا على الكبد عشان في الكبد هيتم
+
+37
+00:03:12,630 --> 00:03:17,590
+ربط الأمونيا بالـ CO2 وتحويل المرتكب إلى يوريا
+
+38
+00:03:17,590 --> 00:03:22,710
+يعني الأمونيا بتتحول اليوريا وين في الكبدوبعد هيك
+
+39
+00:03:22,710 --> 00:03:27,050
+الـUrea بتعمل إليها Execration وطردها مع الـUrine
+
+40
+00:03:27,050 --> 00:03:34,050
+خارج الجسم تمام؟ أيضا يا جماعة الكبد مسئول أن
+
+41
+00:03:34,050 --> 00:03:39,650
+يتخلص من سمية الـBilly Robinالـ Bilirubin له معمل
+
+42
+00:03:39,650 --> 00:03:43,930
+خاص فيه لسبوع الجاي هناخده الـ Bilirubin عبارة عن
+
+43
+00:03:43,930 --> 00:03:49,490
+مادة كينيائية تنتج نتيجة تكسير الـ Hemoglobin اللي
+
+44
+00:03:49,490 --> 00:03:53,170
+موجود في الـ RBCs هلجيت الـ RBCs خلايا الدم الحمرا
+
+45
+00:03:53,170 --> 00:03:58,610
+لما تتكسر؟والـ Hemoglobin اللي جوا هيتكسر بيصير
+
+46
+00:03:58,610 --> 00:04:02,470
+فعنا Release لمادة الـ bilirubin أيضًا مادة الـ
+
+47
+00:04:02,470 --> 00:04:06,510
+bilirubin مادة سامة لو ضلت في الدم بتركيز عالية
+
+48
+00:04:06,510 --> 00:04:11,290
+يعتبر سام فالـ bilirubin اللي بيطلع من الـ RBCs
+
+49
+00:04:11,290 --> 00:04:16,850
+المكسرة وين بيروح؟ أيضًا بيروح على الكبد وفي الكبد
+
+50
+00:04:16,850 --> 00:04:23,370
+بتتم تحويله لمركّبأخر أقل سمية و هذا المركب الأقل
+
+51
+00:04:23,370 --> 00:04:29,350
+سمية بعد هيك بيصير له execution خروج من الجسم
+
+52
+00:04:29,350 --> 00:04:34,870
+تماماًأيضًا الكوليسترول اتفاجنا لما الـ HDL هذا
+
+53
+00:04:34,870 --> 00:04:39,250
+الـ God-cholesterol اللي بيلم الفائض عن حاجة
+
+54
+00:04:39,250 --> 00:04:43,170
+الخلايا وبرجع وين حكينا بيوديه، بيوديه على الكبد
+
+55
+00:04:43,170 --> 00:04:49,110
+والكبد بيه ميكانيزم معين بتخلص من الكوليسترول، إذا
+
+56
+00:04:49,110 --> 00:04:54,120
+بيعمل Detoxificationبتخلص من سمية المواد Drug
+
+57
+00:04:54,120 --> 00:04:58,900
+Metabolism أيضا يا جماعة لما بناخد الأدوية الأدوية
+
+58
+00:04:58,900 --> 00:05:04,400
+لما بناخدها جوا الجسم بميكانيزم معين الدواء بتحول
+
+59
+00:05:04,400 --> 00:05:10,190
+لمركّب وبعدين بتحول لمركّب آخرخلال تحويل الدواء من
+
+60
+00:05:10,190 --> 00:05:14,370
+مُركّب لمُركّب ممكن يتكوّل مُركّب له سمية عالية
+
+61
+00:05:14,370 --> 00:05:19,510
+مين بتخلص من سمية هذا المُركّب الكبد الـ Storage
+
+62
+00:05:19,510 --> 00:05:24,030
+Function اللي هو وظائف تخزينية في الكبد بتم تخزين
+
+63
+00:05:24,030 --> 00:05:28,830
+أنواع كتيرة من الـ Vitamins Vitamin A وD وE وK
+
+64
+00:05:28,830 --> 00:05:33,110
+وVitamin P12 أيضًا الكبد مسؤول عن تصنيع العصارة
+
+65
+00:05:33,110 --> 00:05:36,230
+السفراوية الـ Bile Acid أو ما تسمى بالـ Bile Salt
+
+66
+00:05:36,400 --> 00:05:40,540
+اللي هذه العصارة الصفرية بتلعب دور مهم في إنها
+
+67
+00:05:40,540 --> 00:05:45,800
+بتساعد في هضم الطعام وخاصة في هضم الدهون، تمام؟
+
+68
+00:05:45,800 --> 00:05:49,960
+إذاً هذه الوظائف الأساسية للكبط في الجسم
+
+69
+00:05:55,420 --> 00:06:00,700
+Liver function tests الفحوصات اللي بتشيك على وظائف
+
+70
+00:06:00,700 --> 00:06:05,240
+الكبد هذه الفحوصات تحكي له non-invasive methods
+
+71
+00:06:05,240 --> 00:06:09,420
+for screening of liver dysfunction هذه الفحوصات
+
+72
+00:06:09,420 --> 00:06:14,870
+non-invasive يعني invasive معناها اختراقفعليا يا
+
+73
+00:06:14,870 --> 00:06:18,770
+جماعة هو بالـ slide كاتب non-invasive بس إحنا
+
+74
+00:06:18,770 --> 00:06:24,430
+بنحكي الطريقة invasive يعني بنفوت ال needle
+
+75
+00:06:24,430 --> 00:06:27,490
+بالوريد صح ولا مش صح أنا لما بدي عيّن الدم كيف
+
+76
+00:06:27,490 --> 00:06:32,430
+بحصل على الدم عشان أعمل الفحوصات مش بدخل ال needle
+
+77
+00:06:32,430 --> 00:06:38,200
+في الوريد عشان أسحب الدم فالطريقة invasive تمام؟مش
+
+78
+00:06:38,200 --> 00:06:43,760
+نقطة خلاف المهم إنه إحنا بنسحب عينة الدم و بنعملها
+
+79
+00:06:43,760 --> 00:06:49,280
+الفحوصات اللي بتشيك على الكبد عشان نشوف هل الكبد
+
+80
+00:06:49,280 --> 00:06:55,140
+بيقدي وظيفته ولا في disorder، في مشاكل، تمام؟ فجثة
+
+81
+00:06:55,140 --> 00:06:59,300
+invasive و non-invasive مش نقطة خلافhelp in
+
+82
+00:06:59,300 --> 00:07:04,500
+identifying general types of disorder هذه الفحوصات
+
+83
+00:07:04,500 --> 00:07:09,920
+بتساعدني اني احدد ايش نوع ال disease اللي موجود في
+
+84
+00:07:09,920 --> 00:07:15,780
+الكبد يعني من خلال الفحوصات انا بعرف وبقدر اعرف شو
+
+85
+00:07:15,780 --> 00:07:20,430
+نوع ال problem اللي موجودة في الكبد تمام؟أيضًا من
+
+86
+00:07:20,430 --> 00:07:24,990
+خلال الفحصات بقدر assess severity and allow
+
+87
+00:07:24,990 --> 00:07:30,070
+prediction of outcome بقدر أتندع بشدة المرض يعني
+
+88
+00:07:30,070 --> 00:07:33,490
+من خلال نتيجة الفحص بقدر أحكي والله هذا المريض
+
+89
+00:07:33,490 --> 00:07:37,990
+الكبد عنده متدمر هذا المريض لسه بداية عنده الكبد
+
+90
+00:07:37,990 --> 00:07:44,390
+فيه مشاكل ممكن نلحجه بالعلاج وكذا، تمام؟أيضًا من
+
+91
+00:07:44,390 --> 00:07:50,050
+خلال الفحوصات بقدر أتنبأ بالـ Disease نفسه أعمل
+
+92
+00:07:50,050 --> 00:07:53,790
+متابعة للمرض ومتابعة لل treatment الناس اللي بيكون
+
+93
+00:07:53,790 --> 00:07:58,090
+عندهم مشاكل في الكبت بيعطوهم أنواع من العلاج عشان
+
+94
+00:07:58,090 --> 00:08:04,320
+أعرف هل العلاج يعنيكويس يعني بتحسن المريض مع
+
+95
+00:08:04,320 --> 00:08:07,980
+الإلاج ولا لا ما بقدر أعرف إلا من خلال liver
+
+96
+00:08:07,980 --> 00:08:11,480
+function test من خلال الفحوصات اللي بتشيك على
+
+97
+00:08:11,480 --> 00:08:18,220
+الكبد تمام فهذه يعني وصف للفحوصات أهمية الفحوصات
+
+98
+00:08:18,220 --> 00:08:23,680
+أنه ليش بنعمل فحوصات تشيك على وضع الكبد
+
+99
+00:08:27,080 --> 00:08:32,460
+Liver Function Test فحوصات تشيك على وظائف الكبد
+
+100
+00:08:32,460 --> 00:08:37,160
+proudly classified as هذه الفحوصات اللي بتشيك على
+
+101
+00:08:37,160 --> 00:08:42,080
+وظائف الكبد تم تقسيمها إلى قسمين tests to detect
+
+102
+00:08:42,080 --> 00:08:47,540
+hepatic injury مجموعة من الفحوصات بتشيكلي على و
+
+103
+00:08:47,540 --> 00:08:52,500
+بتكشفلي على ال hepatic injury هل حدث فيه دمار في
+
+104
+00:08:52,500 --> 00:08:57,110
+الكبد؟ومن خلال هذه الفحوصات أنا بقدر أعرف هل
+
+105
+00:08:57,110 --> 00:09:01,650
+المريض عنده المشكلة mild or severe المشكلة بسيطة
+
+106
+00:09:01,650 --> 00:09:07,930
+ولا يعني شديدة والأمور عنده يعني صعبة برضه بقدر
+
+107
+00:09:07,930 --> 00:09:12,510
+أحدد هل المريض عنده المشكلة acute حادة أو chronic
+
+108
+00:09:12,510 --> 00:09:18,040
+عنده مشاكل مزمنة في الكبدأيضًا من خلال الفحوصات
+
+109
+00:09:18,040 --> 00:09:22,540
+بقدر أحدد طبيعة الإصابة اللي انصاب فيها الكبد الـ
+
+110
+00:09:22,540 --> 00:09:28,660
+nature of liver injury هل المشكلة hepatocellular
+
+111
+00:09:28,660 --> 00:09:33,160
+or cholestasis هل المشكلة hepatocellular يعني
+
+112
+00:09:33,160 --> 00:09:38,780
+المشكلة في خلايا الكبد نفسها؟ هل الإصابةأثرت على
+
+113
+00:09:38,780 --> 00:09:44,080
+خلايا الكبد نفسها أو Colistases، Colistases هي الـ
+
+114
+00:09:44,080 --> 00:09:48,940
+Stons، هي الحصاوي أو اتكونت عند حصاوي في الكبد
+
+115
+00:09:48,940 --> 00:09:53,880
+وبالتالي ممكن يعمل مشاكل في الكبد أو ممكن يا جماعة
+
+116
+00:09:53,880 --> 00:09:58,860
+الحصاوي تتكون في الـ Biliary Duct في القناع
+
+117
+00:09:58,860 --> 00:10:03,060
+الصفراوية اللي هي ما بعد الكبد، بتكون بعد الكبد،
+
+118
+00:10:03,060 --> 00:10:08,720
+تمام؟إذا الكوليستاس الحصاوي إما في الكبد نفسه أو
+
+119
+00:10:08,720 --> 00:10:13,380
+في الـBiliary duct في القناع الصفراوية طبعا كل هذا
+
+120
+00:10:13,380 --> 00:10:19,740
+هيأثر على الكبد، تمام؟ الشق الأخر من الفحوصات،
+
+121
+00:10:19,740 --> 00:10:23,660
+عندي مجموعة من الفحوصات بتشيك على الـHepatic
+
+122
+00:10:23,660 --> 00:10:29,780
+function على وظائف الكبد، مثلا الوظيفة التصنيعية
+
+123
+00:10:29,780 --> 00:10:33,180
+يعني أنا لازم يكون عندي فحوصات بتشيك على وظيفة
+
+124
+00:10:33,180 --> 00:10:37,280
+الكبدمن هذه الوظائف التصنيع يعني أنا لازم يكون
+
+125
+00:10:37,280 --> 00:10:42,460
+عندى فحص يقول ليه هل الكبد بيصنع بروتينات كويس ولا
+
+126
+00:10:42,460 --> 00:10:47,780
+الكبد فيه مشكلة وبالتالي هذه المشكلة أثرت على
+
+127
+00:10:47,780 --> 00:10:54,200
+وظيفة التصنيع عنده تمام؟ إذا فحصات بتشيك على خلايا
+
+128
+00:10:54,200 --> 00:10:59,860
+الكبد نفسها والحفاوي وفحصات بتشيك على وظائف الكبد
+
+129
+00:10:59,860 --> 00:11:03,060
+مثل ذلك الوظيفة التصنيعية
+
+130
+00:11:04,960 --> 00:11:10,440
+الـ classification of liver function tests هنا قسم
+
+131
+00:11:10,440 --> 00:11:14,920
+الفحوصات اللي بتشيك على وظائف الكبد إلى ثلاثة
+
+132
+00:11:14,920 --> 00:11:18,680
+أقسام إلى تلاتة group group أول، group تاني، group
+
+133
+00:11:18,680 --> 00:11:23,580
+تالت الجروب الأول markers of liver dysfunction
+
+134
+00:11:23,580 --> 00:11:29,620
+الجروب الأول فحوصات تشيك على وظائف الكبد ال liver
+
+135
+00:11:29,620 --> 00:11:35,960
+function هل الكبد بيؤدي الوظائفالتصنيعية تبعته أو
+
+136
+00:11:35,960 --> 00:11:40,480
+الوظيفة الـ Detoxification تخلص من سمية بعض المواد
+
+137
+00:11:40,480 --> 00:11:45,260
+بالشكل الصحيح ولا لا؟ هاي ال slide ان شاء الله
+
+138
+00:11:45,260 --> 00:11:51,660
+هتكون موضوعنا الإسبوع الجاي، تمام؟اللي هي إنه إحنا
+
+139
+00:11:51,660 --> 00:11:57,240
+بدنا ندرس الفحوصات اللي بتشيك على وظائف الكبد أول
+
+140
+00:11:57,240 --> 00:12:03,520
+فحص الـ Serum Bilirubin نفحص الـ Total Bilirubin و
+
+141
+00:12:03,520 --> 00:12:07,480
+الـ Conjugated Bilirubin هذه أسماء فحوصات Total
+
+142
+00:12:07,480 --> 00:12:12,840
+Bilirubin و Conjugated Bilirubin هنشتغلهم و هنحكي
+
+143
+00:12:12,840 --> 00:12:16,130
+عن هذه الفحوصات الإسبوع الجايتفاجنا إن الـ
+
+144
+00:12:16,130 --> 00:12:21,010
+bilirubin جاي من تكسير ال RBCs و هو مادة ثمة لازم
+
+145
+00:12:21,010 --> 00:12:24,890
+يروح على الكبد و في الكبد يتحول لمادة أخرى و بعد
+
+146
+00:12:24,890 --> 00:12:29,610
+هيك هذه المادة الأخرى بيصيرلها execution تطلع برا
+
+147
+00:12:29,610 --> 00:12:35,090
+الجسمطب لو الكابت فيه مشكلة معناه مش هيقدر يؤدي
+
+148
+00:12:35,090 --> 00:12:39,670
+وظيفة الـ Detoxification معناه مش هيقدر يتخلصني من
+
+149
+00:12:39,670 --> 00:12:44,610
+الـBilly Robin وبالتالي هيصير عندنا مشكلة في جسم
+
+150
+00:12:44,610 --> 00:12:49,570
+الإنسانتمام؟ إذا نفحص الـ Total و الـ Conjugated
+
+151
+00:12:49,570 --> 00:12:54,510
+باللي روبين بيشيكوا على وظيفة الكبد أي وظيفة؟
+
+152
+00:12:54,510 --> 00:13:00,350
+وظيفة الـ Detoxification التخلص من السمية تمام؟
+
+153
+00:13:00,350 --> 00:13:05,810
+أيضا ممكن أجيب عينة urine و أفحص فيها الـ Bile
+
+154
+00:13:05,810 --> 00:13:10,410
+Salt العصارى السفرية و الـ Uropilinogenالـ
+
+155
+00:13:10,410 --> 00:13:14,550
+Europlanogen هذه مادة جاية من الـ Billy Robbins
+
+156
+00:13:14,550 --> 00:13:18,870
+يمكن أخدتوها في السوائل وحتى لو ما أخدتوها الأسبوع
+
+157
+00:13:18,870 --> 00:13:21,930
+اللي جاية هنشرح بالظبط من وين جاية بس هلجيت على
+
+158
+00:13:21,930 --> 00:13:25,710
+السريع الـ Europlanogen هذه مادة جاية من الـ Billy
+
+159
+00:13:25,710 --> 00:13:30,640
+Robbinsتمام؟ فأنا لو فحصت هذه المادة في الـ urine
+
+160
+00:13:30,640 --> 00:13:37,260
+وفحصت العصارة الصفراوية بقدر برضه أقيم هل الكبد
+
+161
+00:13:37,260 --> 00:13:43,060
+بيقدّي وظيفته ولا لأ، تمام؟ هل الكبد بينتج bile
+
+162
+00:13:43,060 --> 00:13:47,320
+salt ولا لأ؟ إذا أنا هنا بشيك على الوظيفة
+
+163
+00:13:47,320 --> 00:13:53,530
+التصنيعية للكبد، تمام؟إنه بنتز Bile Salt ولا لا
+
+164
+00:13:53,530 --> 00:13:58,790
+برضه لو أنا عملت فحص الـ Total Protein وفحص
+
+165
+00:13:58,790 --> 00:14:04,490
+الألبومان وفحص آخر بيسموه ألبومان على Globulin
+
+166
+00:14:04,490 --> 00:14:08,950
+Ratio أنا هيك برضه بشيك على الوظيفة التصنيعية
+
+167
+00:14:08,950 --> 00:14:13,190
+للكبت لأنه لو طلع الـ Total Bilirub نواط كتير عند
+
+168
+00:14:13,190 --> 00:14:19,200
+المريض sorry الـ Total Proteinلو طلعت تركيز
+
+169
+00:14:19,200 --> 00:14:23,560
+البروتينات في الجسم واطي كتير بفهم إن الكبد تصنيعه
+
+170
+00:14:23,560 --> 00:14:28,120
+ما بيصنعه كويس تمام؟ فيه مشكلة أثرت على التصنيع
+
+171
+00:14:28,120 --> 00:14:32,060
+برضه يا جماعة فحص الـBT اللي أخدناه في النزف
+
+172
+00:14:32,060 --> 00:14:36,480
+البراثروم بين تايم أنا لما بعمل فحص الـBT مش إني
+
+173
+00:14:36,480 --> 00:14:42,930
+بس بشيك على شغلات بتتعلق بالنزفأنا هنا بشيك على
+
+174
+00:14:42,930 --> 00:14:48,650
+الوظيفة التصنيعية للكبد مش الكبد بيصنع الـ factor
+
+175
+00:14:48,650 --> 00:14:53,030
+الـ coagulation factor عوامل التخثر اللي هي حكينا
+
+176
+00:14:53,030 --> 00:14:56,830
+عوامل التجلط هي عبارة عن الـ بروتينات وبالتالي انت
+
+177
+00:14:56,830 --> 00:15:03,350
+لما بتعملي فحص الـ BT انت هيك بتشيكي على عوامل
+
+178
+00:15:03,350 --> 00:15:07,650
+التجلط الـ coagulation factor لأن معظمها بتصنع في
+
+179
+00:15:07,650 --> 00:15:08,330
+الكبد
+
+180
+00:15:11,200 --> 00:15:15,180
+الجروب التاني من الفحوصات Markers of
+
+181
+00:15:15,180 --> 00:15:21,080
+Hepatocellular Injury فحوصات بتشيك على خلايا الكبد
+
+182
+00:15:21,080 --> 00:15:25,820
+نفسها هل خلايا الكبد نفسها حدث فيها damage، ضمار،
+
+183
+00:15:25,820 --> 00:15:32,110
+injury، إصابة هذه الفحوصات عبارة عن فحسينالـ ALT
+
+184
+00:15:32,110 --> 00:15:37,550
+والـ AST هذه عبارة عن أنزيمات أول أنزيم اسمه
+
+185
+00:15:37,550 --> 00:15:41,070
+Alanine Aminotransferase والـ Aspartate
+
+186
+00:15:41,070 --> 00:15:45,890
+Aminotransferase هدولة فحصين بيشيكوا على خلايا
+
+187
+00:15:45,890 --> 00:15:50,050
+الكبدة هل حدث فيها injury ولا لأ؟ وهذا موضوعنا
+
+188
+00:15:50,050 --> 00:15:55,890
+اليوم إن شاء الله إن نحكي عن فحص الـ ALT والـ AST
+
+189
+00:15:58,400 --> 00:16:03,060
+الجروب التالت Markers of Cholestases فى عندي
+
+190
+00:16:03,060 --> 00:16:07,560
+مجموعة من الفحوصات بتشيك هل فى Cholestases فى
+
+191
+00:16:07,560 --> 00:16:13,020
+Stones حصاوي اتكونت فى الـ Biliary Duct فى القناع
+
+192
+00:16:13,020 --> 00:16:19,180
+الصفراوية اللى تيجي بعد الكبد تمام؟ هذه الفحوصات
+
+193
+00:16:19,180 --> 00:16:25,150
+هما الـ ALB والـ GGT برضه عبارة عن أنزايمAlkaline
+
+194
+00:16:25,150 --> 00:16:30,150
+Phosphatase الـ ALB والـ GGT اسمه الـ Gamma
+
+195
+00:16:30,150 --> 00:16:35,050
+Glutamyl Transferase إذن هدول الفحوصات بيشيكوا هل
+
+196
+00:16:35,050 --> 00:16:39,890
+في كل الـ Stasis في الـ Biliary Duct ولا لأ برضه
+
+197
+00:16:39,890 --> 00:16:42,510
+هذه الفحوصات موضوعنا لليوم
+
+198
+00:16:45,920 --> 00:16:50,740
+الـ Liver enzymes إنزيمات الكبد خلونا نبدأ
+
+199
+00:16:50,740 --> 00:16:55,740
+بالفحوصات اللي بتشيك على الـHepatocellular injury
+
+200
+00:16:55,740 --> 00:17:00,300
+على خلايا الكبد نفسها هل فيه دمش في خلايا الكبد
+
+201
+00:17:00,300 --> 00:17:04,660
+نفسها ولا لا حكينا هذه الإنزيمات عبارة عن two
+
+202
+00:17:04,660 --> 00:17:10,500
+enzymes الـALT والـAST تمام؟ هنبدأ أول إشي في
+
+203
+00:17:10,500 --> 00:17:17,900
+الـASTأمينو ترانس فيريزز أمينو ترانس فيريزز أو
+
+204
+00:17:17,900 --> 00:17:23,080
+إلها اسم آخر لـ Transaminases are a group of
+
+205
+00:17:23,080 --> 00:17:28,480
+enzymes هذه اسم عيلة كبير إذا الأمينو ترانس فيريزز
+
+206
+00:17:28,480 --> 00:17:34,310
+أو اسم آخر لـ Transaminases هذه اسم عيلةهذه العيلة
+
+207
+00:17:34,310 --> 00:17:40,210
+بتضم مجموعة من الإنزيمات are a group of enzymes هي
+
+208
+00:17:40,210 --> 00:17:45,370
+مجموعة من الإنزيمات الوظيفة الأساسية للـ Amino
+
+209
+00:17:45,370 --> 00:17:51,020
+Transferasesthat catalyze the interconversion of
+
+210
+00:17:51,020 --> 00:17:55,540
+amino acid and keto acid by transfer of amino
+
+211
+00:17:55,540 --> 00:17:59,580
+group إذن الـ Aminotransferases أو الـ
+
+212
+00:17:59,580 --> 00:18:06,200
+Transaminases هذه عبارة عن اسم عيلة بتضم مجموعة من
+
+213
+00:18:06,200 --> 00:18:12,370
+الانزيمات هذه الانزيماتالوظيفة الأساسية لإلها إنها
+
+214
+00:18:12,370 --> 00:18:19,490
+تنجل amino group مجموعة amino group تنجلها من الـ
+
+215
+00:18:19,490 --> 00:18:24,610
+amino acid من الأحماض الأمينية إلى الـ keto acid
+
+216
+00:18:24,610 --> 00:18:30,770
+إلى الأحماض الكيتونية، تمام؟إذاً كمان مرة الـ
+
+217
+00:18:30,770 --> 00:18:34,890
+Aminotransferases أو الـ Transaminases هم مجموعات
+
+218
+00:18:34,890 --> 00:18:38,490
+من الانزيمات هذه اسم العيلة بتضم مجموعة من
+
+219
+00:18:38,490 --> 00:18:42,990
+الانزيمات الوظيفة الأساسية لها نقل Amino group
+
+220
+00:18:42,990 --> 00:18:48,010
+مجموعة Amino group من الـ amino acid من الأحماض
+
+221
+00:18:48,010 --> 00:18:55,270
+الأمينية إلى الـ keto acid الأحماض الكيتونية تمام؟
+
+222
+00:18:56,180 --> 00:19:00,700
+The two aminotransferases of greatest clinical
+
+223
+00:19:00,700 --> 00:19:04,760
+significance are هذه العيلة الكبيرة حكينا بتضم
+
+224
+00:19:04,760 --> 00:19:09,740
+مجموعة من الإنزيمات أهم two enzymes في العيلة هما
+
+225
+00:19:09,740 --> 00:19:15,740
+الـ AST والـ ALT هذه الفحوصات أو هذه الإنزيمات لها
+
+226
+00:19:15,740 --> 00:19:20,460
+وظائف تشخيصية من خلالها أنا بقدر أشيك على خلايا
+
+227
+00:19:20,460 --> 00:19:27,590
+الكبد حدث فيها injury أو سليمةإذن أول إنزين مهم
+
+228
+00:19:27,590 --> 00:19:33,850
+الـ AST اسمه Aspartate Aminotransferase اسم آخر
+
+229
+00:19:33,850 --> 00:19:40,690
+للإنزين Glutamate Oxaloacetate Transaminase أو
+
+230
+00:19:40,690 --> 00:19:46,670
+بيحكوا عنه الـ GOT إذن الإختصارات مهمة اسم الإنزين
+
+231
+00:19:46,670 --> 00:19:53,990
+AST أو GOT تمام إلى إسمينالإنزايم الآخر الـ ALT
+
+232
+00:19:53,990 --> 00:19:58,890
+اختصاري الانين امينو ترانس فريز الاسم الآخر
+
+233
+00:19:58,890 --> 00:20:04,370
+للإنزايم أجلوتاميت بايروفيت ترانس أمينيز أو
+
+234
+00:20:04,370 --> 00:20:11,320
+الإختصار GUPTالـ AST بيحكوا عنه الـ Got والـ ALT
+
+235
+00:20:11,320 --> 00:20:16,360
+بيحكوا عنه الـ Gept هذه أسماء أخرى للإنزيمات الـ
+
+236
+00:20:16,360 --> 00:20:22,260
+Pyridoxal Phosphate أو بيسموه الـ B5B هذا يعتبر
+
+237
+00:20:22,260 --> 00:20:28,380
+الـ core enzyme أو الـ core factor هذا يعتبر هو
+
+238
+00:20:28,380 --> 00:20:34,080
+اللي بينشط ال enzymes الـ AST والـ ALT أو العيلة
+
+239
+00:20:34,080 --> 00:20:39,400
+كلها يعني الإنزيماتإنزيمات الـ Amino Transferase
+
+240
+00:20:39,400 --> 00:20:44,180
+إنزيمات هذه العيلة عشان تشتغل يا جماعة بدها محفز
+
+241
+00:20:44,180 --> 00:20:48,580
+بدها Co-Factor بدها Co-Enzyme الـ Co-Enzyme لهذه
+
+242
+00:20:48,580 --> 00:20:54,600
+العيلة هو مادة الـ Pyridoxal Phosphate تمام؟ من
+
+243
+00:20:54,600 --> 00:21:02,640
+غيره الإنزيمات ما بتشتغل وما بتأدي وظيفتهانبدأ ان
+
+244
+00:21:02,640 --> 00:21:06,780
+شاء الله بالفحوصات اللي بتشيك على الـ
+
+245
+00:21:06,780 --> 00:21:11,720
+Hepatocellular injury على خلايا الكبد نفسها حكينا
+
+246
+00:21:11,720 --> 00:21:17,940
+two enzyme الـ AST والـ ALT ونبدأ بأول enzyme الـ
+
+247
+00:21:17,940 --> 00:21:24,790
+AST test فحص الـ ASTAspartate Amino Transferase
+
+248
+00:21:24,790 --> 00:21:29,830
+الـ AST involved in the transfer of amino group
+
+249
+00:21:29,830 --> 00:21:37,160
+between الأسبرتات and الألفا كيتو أسدبحكيلي هنا إن
+
+250
+00:21:37,160 --> 00:21:41,880
+الـ AST إيش الوظيفة الأساسية له هذا الـ enzyme
+
+251
+00:21:41,880 --> 00:21:50,940
+ينجلّي amino group من مُركّب الأسبرتات لمركّب الـ
+
+252
+00:21:50,940 --> 00:21:57,040
+Alpha Ketoglutarate لو جيته على الرسمة هي
+
+253
+00:21:57,040 --> 00:22:01,820
+الأسبرتات، مادة الأسبرتات ترتبط مع مادة الـ Alpha
+
+254
+00:22:01,820 --> 00:22:09,140
+Ketoglutarateفي وجود إنزايم الـ ASTالـ Aspartate
+
+255
+00:22:09,140 --> 00:22:15,420
+هيتم هذا الـ enzyme الـ AST هينجل amino group من
+
+256
+00:22:15,420 --> 00:22:21,280
+مادة الـ Aspartate لمادة الـ Alpha-Keto إجلوترات
+
+257
+00:22:21,280 --> 00:22:27,020
+إيه المحصلة؟ الـ Aspartate هيتحول لـ Oxaloacetate
+
+258
+00:22:27,020 --> 00:22:33,100
+والـ Alpha-Keto إجلوترات هتتحول لإجلوتامات يعني
+
+259
+00:22:33,100 --> 00:22:37,600
+نتيجة نجل amino group من الـ Aspartateللـ Alpha
+
+260
+00:22:37,600 --> 00:22:42,380
+Keto Glutarate الـ Aspartate تتحول لـ Oxaloacetate
+
+261
+00:22:42,380 --> 00:22:46,720
+والـ Alpha Keto Glutarate اتحول لـ Glutamate يا
+
+262
+00:22:46,720 --> 00:22:51,340
+جماعة التفاعل مش حفظ ما بيعني ان يتحفظوه أخدتوه في
+
+263
+00:22:51,340 --> 00:22:54,660
+الحيوية وأكيد فاهمينه وعارفينه بس كنتوا يعرفوا انه
+
+264
+00:22:54,660 --> 00:22:57,680
+بينجل Amino Group من الـ Aspartate للـ Alpha Keto
+
+265
+00:22:57,680 --> 00:23:04,550
+Glutarate هذه الوظيفة الأساسية للـ AST تمام؟الـ
+
+266
+00:23:04,550 --> 00:23:09,250
+Clinical Significance يعني الأهمية الطبية لهذا
+
+267
+00:23:09,250 --> 00:23:14,830
+الفحص، لفحص الـ AST الـ AST الـ Aspartate Amino
+
+268
+00:23:14,830 --> 00:23:19,230
+Transferase is an enzyme found primarily in the
+
+269
+00:23:19,230 --> 00:23:23,150
+heart, liver and muscle هذا الـ enzyme يا جماعة
+
+270
+00:23:23,150 --> 00:23:30,190
+بشكل أساسي موجود في القلب وموجود جوا الكبد وموجود
+
+271
+00:23:30,190 --> 00:23:35,250
+في ال muscle في العضلات، تمام؟إذاً بدنا نتفج إن
+
+272
+00:23:35,250 --> 00:23:40,350
+انزايم الـ AST مكانه أصلي موجود في عضلة القلب
+
+273
+00:23:40,350 --> 00:23:45,410
+وموجود في الكبد وموجود في العضلات طب لو سألناكم
+
+274
+00:23:45,410 --> 00:23:51,010
+سؤال الـ AST هذا الانزايم موجود في الدم ولا لا؟
+
+275
+00:23:51,010 --> 00:23:55,870
+موجود في بلازمة الدم ولا لا؟ هجاوبكم صحيح موجود في
+
+276
+00:23:55,870 --> 00:24:01,440
+بلازمة الدم ولكنالـ Concentration قليل جدا، يعني
+
+277
+00:24:01,440 --> 00:24:06,360
+موجود في البلازمة تبعتنا، ولكن بتركيز قليل جدا،
+
+278
+00:24:06,360 --> 00:24:10,860
+هذا الإنسان الطبيعي، إذا الإنسان الطبيعي لو فحصله
+
+279
+00:24:10,860 --> 00:24:15,740
+الـ AST، لازم يكون الـ AST قليل جدابلا
+
+280
+00:24:15,740 --> 00:24:21,000
+Concentration موجود في بلازمة الدم لأنه بشكل أساس
+
+281
+00:24:21,000 --> 00:24:24,960
+الـ AST ما بيكون موجود في الدم بكميات كبيرة هو يما
+
+282
+00:24:24,960 --> 00:24:31,160
+كانوا في الكبد و في عضلة القلب و في العضلات الأخرى
+
+283
+00:24:31,160 --> 00:24:35,980
+تمام؟Additional AST is released into the
+
+284
+00:24:35,980 --> 00:24:40,700
+circulation after injury or death of cells تخيلوا
+
+285
+00:24:40,700 --> 00:24:46,560
+معي الخلايا الكبد بدأ يصير فيها damage بدأ يصير
+
+286
+00:24:46,560 --> 00:24:51,820
+فيها تدمير إيش هيصير لما خلايا الكبد تتدمر؟ هيصير
+
+287
+00:24:51,820 --> 00:24:57,940
+في عندي release، تسربلـ Enzyme الـ AST من خلايا
+
+288
+00:24:57,940 --> 00:25:04,080
+الكبد إلى إبلازمة الدم وبالتالي لو جيت للإنسان
+
+289
+00:25:04,080 --> 00:25:08,600
+اللي عنده مشكلة في خلايا الكبد عنده damage وفحصتله
+
+290
+00:25:08,600 --> 00:25:13,980
+الـ AST هلاجي تركيز الـ AST عنده في الدم عالي جدا
+
+291
+00:25:13,980 --> 00:25:18,810
+فلما لاجي تركيز الـ AST في الدم عالي جدابدنا نفهم
+
+292
+00:25:18,810 --> 00:25:24,830
+بسرعة إن هذا الشخص ممكن يكون ساير عنده مشكلة في
+
+293
+00:25:24,830 --> 00:25:29,110
+خلايا الكبد وتدمير في خلايا الكبد وبالتالي أدى ذلك
+
+294
+00:25:29,110 --> 00:25:34,390
+لخروج الـ enzyme من مكانه الأصلي من الكبد إلى
+
+295
+00:25:34,390 --> 00:25:41,220
+البلازما الدميعني الـ AST بيزيد في الدم بعد حدوث
+
+296
+00:25:41,220 --> 00:25:48,160
+death موت للخلايا أو إصابة لخلايا الكبد أو خلايا
+
+297
+00:25:48,160 --> 00:25:54,380
+القلب أو العضلات نفسها، تمام؟This test is one of
+
+298
+00:25:54,380 --> 00:25:57,880
+the several that are performed when there has been
+
+299
+00:25:57,880 --> 00:26:02,280
+damage to the heart muscle as in myocardial
+
+300
+00:26:02,280 --> 00:26:07,000
+infarction and in assessing liver damage هذا الفحص
+
+301
+00:26:07,000 --> 00:26:12,560
+يا جماعة يبين عمل أيضا لو حسينا في عنا مشكلة في
+
+302
+00:26:12,560 --> 00:26:18,800
+عضلة القلب حدوث مثلا تدمير في خلايا عضلة القلبلما
+
+303
+00:26:18,800 --> 00:26:22,860
+يصير عندي مشكلة دمش في القلب مشكلة في القلب وفي
+
+304
+00:26:22,860 --> 00:26:27,380
+خلايا القلب برضه الـ ASD الموجود في القلب هيبقى
+
+305
+00:26:27,380 --> 00:26:31,840
+يطلع من القلب ويروح وين وييجي على الدم وبالتالي
+
+306
+00:26:31,840 --> 00:26:36,100
+يذداد تركيزه في الدم أيضا في حالات الـ myocardial
+
+307
+00:26:36,100 --> 00:26:41,000
+infarction الذبح القلبية الذبح القلبية برضه خلايا
+
+308
+00:26:41,000 --> 00:26:46,260
+القلب برضه بيصير فيها damageبرضه هيطلع الـ ASD من
+
+309
+00:26:46,260 --> 00:26:51,660
+القلب للدم وبالتالي يزيد تركيزه في الدم أيضا حالات
+
+310
+00:26:51,660 --> 00:26:56,920
+ال liver damage يعني يا جماعة من هاي ل slide بس
+
+311
+00:26:56,920 --> 00:27:02,280
+تنتج أن فحص ال ASD فحص مش specific زي اليوريا لما
+
+312
+00:27:02,280 --> 00:27:08,600
+حكينا عن اليوريا و ال kidneyإذن فحص الـ AST فحص مش
+
+313
+00:27:08,600 --> 00:27:15,100
+متخصص لمشاكل الكبد ليش؟ لأن الـ AST موجود بأكتر من
+
+314
+00:27:15,100 --> 00:27:19,280
+مكان موجود في الكبد وفي القلب وفي العضلات فلما
+
+315
+00:27:19,280 --> 00:27:24,970
+يصير damage سواء في الكبدأو في القلب أو في العضلات
+
+316
+00:27:24,970 --> 00:27:30,930
+already هيزيد تركيزه في الدم فهو مش خاص بس لمشاكل
+
+317
+00:27:30,930 --> 00:27:35,990
+الكبل برضه هو بيزيد في حالات مشاكل القلب ومشاكل
+
+318
+00:27:35,990 --> 00:27:41,660
+العضلاتتمام؟ okay بنرجع نحكي إنه مش متخصص للكبد
+
+319
+00:27:41,660 --> 00:27:46,640
+على الرغم من إنه مش متخصص إلا إنه بيعتبر فحص من
+
+320
+00:27:46,640 --> 00:27:52,100
+الفحوصات اللي بتشيك على الكبد تمام؟ infants levels
+
+321
+00:27:52,100 --> 00:27:56,480
+approximately twice the adult level بحكي للأطفال
+
+322
+00:27:56,480 --> 00:28:03,240
+بيكون عندهم تركيزيعني الموليد الجدد والأطفال بيكون
+
+323
+00:28:03,240 --> 00:28:08,240
+عندهم تركيز الـ Enzyme الـ AST فدًا أعلى من الـ
+
+324
+00:28:08,240 --> 00:28:13,480
+Adult بمرتين تمام؟ بعد هيك، بيبدأ التركيز عندهم
+
+325
+00:28:13,480 --> 00:28:21,860
+يقل لحد ما يصل للتركيز اللي يفترض يكون موجود عند
+
+326
+00:28:21,860 --> 00:28:26,900
+الـ Adult وهذا بيصير حوالي أول 6 شهور يعني أول ما
+
+327
+00:28:26,900 --> 00:28:32,150
+ينولد الطفلالجنين يعني الـ fetus نفسه أول ما ينولد
+
+328
+00:28:32,150 --> 00:28:36,430
+الـ newborn الموليد الجدد أول ما ينولده بيكون
+
+329
+00:28:36,430 --> 00:28:41,870
+عندهم تركيز الـ AST أعلى من الـ Adult بمرتين بعد
+
+330
+00:28:41,870 --> 00:28:46,590
+هيك لما بيصير عمره 6 شهور ال baby لما بيصير عمره 6
+
+331
+00:28:46,590 --> 00:28:52,010
+شهور خلاص تركيز الـ AST بيصير عنده نفس تركيز الـ
+
+332
+00:28:52,010 --> 00:28:58,540
+AST اللي موجود عند الـ Adult تمام؟معلومة مش كتير
+
+333
+00:28:58,540 --> 00:29:04,280
+بنركز عليها، يعني أهم إشي نفهم الـ AST وين موجود،
+
+334
+00:29:04,280 --> 00:29:08,440
+وتركيزه في الدم بيكون قليل، تمام؟ في حال حد ازدمج
+
+335
+00:29:08,440 --> 00:29:12,300
+في الكبد أو في القلب أو في العضلات، هيطلع من هذه
+
+336
+00:29:12,300 --> 00:29:16,320
+الأماكن للدم، وبالتالي يزيد، وبالتالي هيزيد
+
+337
+00:29:16,320 --> 00:29:22,600
+تركيزه، بس هذا المهم في هذه الـ slideالـ specimen
+
+338
+00:29:22,600 --> 00:29:26,300
+collection يعني لما يجيني patient بدي أعمله فحص
+
+339
+00:29:26,300 --> 00:29:32,380
+الـ AST شو العينة اللي بنستخدمها Serum or بلازمة و
+
+340
+00:29:32,380 --> 00:29:35,700
+لما بدي أجمع في بلازمة الـ anticoagulant المسموح
+
+341
+00:29:35,700 --> 00:29:40,700
+فيها إما Edeta أو Hiberin، تمام؟ هي النقطة الأولى
+
+342
+00:29:40,700 --> 00:29:44,200
+النقطة التانية بدي ياكوا تركزوا معاههل جيت اتفجنا
+
+343
+00:29:44,200 --> 00:29:49,640
+إن الـ AST موجود بشكل أساسي في الـ liver و في ال
+
+344
+00:29:49,640 --> 00:29:52,800
+heart في الكبط و القلب و ال muscle و العضلات
+
+345
+00:29:52,800 --> 00:29:58,460
+وضيفوا كمان موقع رابع للـ AST أيضًا الـ AST موجود
+
+346
+00:29:58,460 --> 00:30:04,760
+جوات ال RBCs جوات خلايا الدم الحمرة، تمام؟إذن الـ
+
+347
+00:30:04,760 --> 00:30:09,360
+ASD موجود في الـ heart والـ liver والـ muscle والـ
+
+348
+00:30:09,360 --> 00:30:15,240
+RBCs وبالتالي يا جماعة Hemolysis should be avoided
+
+349
+00:30:15,240 --> 00:30:20,100
+because it can dramatically increase السيرم ASD
+
+350
+00:30:20,100 --> 00:30:24,600
+concentration أي عينة hemolized لازم أعملها
+
+351
+00:30:24,600 --> 00:30:28,720
+rejection لما بدك تشتغلي فحص الـ ASD أي عينة
+
+352
+00:30:28,720 --> 00:30:33,340
+سيريلها Hemolysisيعني الـ RBCs فيها متكسر، هذه
+
+353
+00:30:33,340 --> 00:30:38,640
+العينة ممنوع استخدمها، ليش؟ لأن الـ Hemolysis هيؤد
+
+354
+00:30:38,640 --> 00:30:43,780
+إلى تكسير الـ RBCs، هيؤد إلى خروج الـ AST من
+
+355
+00:30:43,780 --> 00:30:49,160
+موقعه، من الـ RBCs إلى الـ Serum، تمام؟ وبالتالي،
+
+356
+00:30:49,160 --> 00:30:54,180
+أنا باجي بفحص للمريضبلاجي عنده الـ AST عالي كتير
+
+357
+00:30:54,180 --> 00:30:59,720
+في السيرة طب هل هو عالي لإنه عنده مشكلة مرضية ولا
+
+358
+00:30:59,720 --> 00:31:05,840
+الـ AST عالي لإنه عندي خلل في جمع العينة صار
+
+359
+00:31:05,840 --> 00:31:10,170
+Hemolysisوبالتالي طلع الـ AST من الـ RBCs على الـ
+
+360
+00:31:10,170 --> 00:31:17,050
+Serum وزود تركيزه بشكل خاطئ تمام؟ إذن يا جماعة الـ
+
+361
+00:31:17,050 --> 00:31:21,910
+AST موجود بشكل أساسي في الـ RBCs فأثناء جمع العينة
+
+362
+00:31:21,910 --> 00:31:26,070
+بدي أتجنب الـ Hemolysis لأنه بخاف الـ RBCs تتكسر
+
+363
+00:31:26,070 --> 00:31:31,490
+ويطلع منها الـ AST ويطلع على الـ Serum ويزود تركيز
+
+364
+00:31:31,490 --> 00:31:37,760
+الـ AST بشكل خاطئ معلومةبحكيلك الـ RBCs contain
+
+365
+00:31:37,760 --> 00:31:43,220
+خمس أضعاف الـ AST الموجود في السيرم الـ RBCs
+
+366
+00:31:43,220 --> 00:31:47,560
+بتحتوي على AST، هي الفكرة أن الـ RBCs بتحتوي على
+
+367
+00:31:47,560 --> 00:31:53,880
+AST بكميات كبيرة أكتر من الـ AST الموجود في
+
+368
+00:31:53,880 --> 00:31:55,720
+السيرم، تمام؟
+
+369
+00:31:58,430 --> 00:32:02,330
+الـ «Say for enzyme activity» بدنا نشوف الطرق
+
+370
+00:32:02,330 --> 00:32:06,330
+المستخدمة لقياس نشاط الإنزايم في الـ Serum إحنا يا
+
+371
+00:32:06,330 --> 00:32:10,670
+جماعة ما بنقيس تركيز الإنزايم في الـ Serum كتاتنا
+
+372
+00:32:10,670 --> 00:32:14,810
+بتقيس مدى نشاط الإنزايم الـ activity تبع الإنزايم
+
+373
+00:32:14,810 --> 00:32:19,430
+ولمّا إحنا بنقيس ال activity، الـ activity تعبر عن
+
+374
+00:32:19,430 --> 00:32:26,840
+تركيز الإنزايم، تمام؟measurement by Karman method
+
+375
+00:32:26,840 --> 00:32:31,520
+إحنا بنقيس الـ AST بنقيس نشاطه في الـ Serum بطريقة
+
+376
+00:32:31,520 --> 00:32:36,340
+الـ Karman method a coupled reaction involving
+
+377
+00:32:36,340 --> 00:32:40,060
+التفاعل لابد من وجود فيه الـ Pyridoxal 5-Fosfate
+
+378
+00:32:40,060 --> 00:32:44,240
+هذا الـ cofactor اللي بينشط الإنزايم و بيخليه
+
+379
+00:32:44,240 --> 00:32:47,640
+يقدّي وظيفته لازم يكون فيه في التفاعل ملات
+
+380
+00:32:47,640 --> 00:32:52,650
+Dehydrogenase هنشوف شو وظيفتهالـ Reaction كله
+
+381
+00:32:52,650 --> 00:32:57,450
+هيكون على 37 درجة سليزيوس يعني أنا فعليًا هشتغل
+
+382
+00:32:57,450 --> 00:33:01,470
+التفاعل على الـ Water Bath مش على الـ Room
+
+383
+00:33:01,470 --> 00:33:06,330
+Temperature في محصلة التفاعل هنقرأ الـ Decrease في
+
+384
+00:33:06,330 --> 00:33:09,610
+الـ Absorbance القلة في الـ Absorbance على
+
+385
+00:33:09,610 --> 00:33:15,690
+wavelength 340يعني هستخدم كيوفيت خاصة مصنوعة من
+
+386
+00:33:15,690 --> 00:33:20,550
+الذجاج مش لبلاستيك كيوفيت لإن ال wavelengths
+
+387
+00:33:20,550 --> 00:33:23,550
+تلاتمية وأربعين يعني أنا بقرأ في منطقة ال
+
+388
+00:33:23,550 --> 00:33:27,570
+ultraviolet المنطقة الفوق بنفس جيهة إلها كيوفيت
+
+389
+00:33:27,570 --> 00:33:32,650
+خاصة تمام؟هل جيت المربع الأزرق؟ هنحكي الـ
+
+390
+00:33:32,650 --> 00:33:37,610
+principle للفحص، مبدأ الفحص، كيف الفحص بيصير هل
+
+391
+00:33:37,610 --> 00:33:40,250
+جيت يا جماعة الـ serum تبع ال patient، تبع
+
+392
+00:33:40,250 --> 00:33:43,810
+الإنسان، موجود في الـ ASC، موجود في الـ enzyme
+
+393
+00:33:43,810 --> 00:33:48,390
+اللي أنا بدي أقيس ال activity تبعته، تمام؟والـ
+
+394
+00:33:48,390 --> 00:33:53,070
+Reagent اللي موجود في الـ kit يحتوي على substrate
+
+395
+00:33:53,070 --> 00:33:59,430
+يحتوي على المواد اللي هيشتغل عليها الـ enzyme لأن
+
+396
+00:33:59,430 --> 00:34:04,870
+الـ Reagent هيكون فيه مادة الـ Aspartate ومادة الـ
+
+397
+00:34:04,870 --> 00:34:08,110
+Alpha-keto-glutarate زي ما انتوا شايفين بالسندوق
+
+398
+00:34:08,110 --> 00:34:13,210
+الأزرقأذن أسبرتاد زائد ألفا كيتوجلوترات هذه
+
+399
+00:34:13,210 --> 00:34:17,550
+الـsubstrates موجودة في الـreagent اللي هيشتغل
+
+400
+00:34:17,550 --> 00:34:21,990
+عليها الـenzyme اللي موجود في الـserum إذن بدنا
+
+401
+00:34:21,990 --> 00:34:26,160
+نتخيل الـASC موجود في الـserumوالـ Aspartate والـ
+
+402
+00:34:26,160 --> 00:34:29,800
+Alpha-Keto إجلوترات موجودين في الـ Reagent لما
+
+403
+00:34:29,800 --> 00:34:34,120
+بخلط الـ Reagent على الـ Serum الـ AST الموجود في
+
+404
+00:34:34,120 --> 00:34:38,240
+الـ Serum هيشتغل على الـ Aspartate والـ Alpha-Keto
+
+405
+00:34:38,240 --> 00:34:45,340
+إجلوترات ويحولهم لمواد أخرى هي الـ Oxaloacetate
+
+406
+00:34:45,340 --> 00:34:51,060
+زائد لجلوتمات، تمام؟هل جيت الـ Oxaloacetate مع الـ
+
+407
+00:34:51,060 --> 00:34:56,280
+NAD H والـ H Plus في وجود الـ ND اللي هو الملات
+
+408
+00:34:56,280 --> 00:34:59,340
+الـ dehydrogenase انزايم بيكون موجود ضمن الـ
+
+409
+00:34:59,340 --> 00:35:04,700
+Reagent هيحول الـ Oxaloacetate لملات و هيحول الـ
+
+410
+00:35:04,700 --> 00:35:10,070
+NAD H إلى NADأنا هقرأ الـ Decrease في الـ
+
+411
+00:35:10,070 --> 00:35:14,330
+Absorbance تفاجنا في أول معامل لما بيكون عند ناد
+
+412
+00:35:14,330 --> 00:35:18,810
+أتش ويتحول لناد في الـ Reaction معناه الـ
+
+413
+00:35:18,810 --> 00:35:24,850
+Absorbance هيقل إذا أنا بقرأ الـ Decrease في الـ
+
+414
+00:35:24,850 --> 00:35:32,920
+Absorbance على 340 الـ Wavelengthوبعلاقة معينة بتم
+
+415
+00:35:32,920 --> 00:35:37,920
+حساب ال activity تبعت ال enzyme وبعلاقة معينة
+
+416
+00:35:38,920 --> 00:35:45,380
+وبفاكتر معين هنعطيكم إياه بتم حساب نشاط الـ enzyme
+
+417
+00:35:45,380 --> 00:35:50,760
+و ال activity تبعت ال enzyme هي هتعبر عن تركيز ال
+
+418
+00:35:50,760 --> 00:35:55,240
+enzyme في ال serum يا جماعة هذا مبدأ الفحص ال
+
+419
+00:35:55,240 --> 00:36:00,080
+procedure خطوة بخطوتها هنحكيها في المعمل ما بينفع
+
+420
+00:36:00,080 --> 00:36:04,450
+نحكيها هيك لازم نكتبها كتابة ع الصبورةلما نشتغل
+
+421
+00:36:04,450 --> 00:36:07,970
+فحص الـ AST لما نرجع الجامعة هنعطيكم الـ procedure
+
+422
+00:36:07,970 --> 00:36:12,070
+خطوة خطوة و هنشوف كيف بنشتغل فحص الـ AST
+
+423
+00:36:12,070 --> 00:36:18,740
+بالسلايدات مش موجودة هنحكيها بالمعمل، تمام؟الـ
+
+424
+00:36:18,740 --> 00:36:22,840
+Normal Range لفحص الـ AST من تمانية لعشرين
+
+425
+00:36:22,840 --> 00:36:28,380
+International Unit Per Liter هذه وحدة قياس
+
+426
+00:36:28,380 --> 00:36:33,680
+الإنزيمات IU Per Liter International Unit Per
+
+427
+00:36:33,680 --> 00:36:38,150
+Literpost-acute myocardial infarction تفاجنا
+
+428
+00:36:38,150 --> 00:36:42,470
+معلومة بسيطة إن الـ AST موجود في الـ heart فلو
+
+429
+00:36:42,470 --> 00:36:46,570
+انصاب الإنسان بالـ acute myocardial infarction
+
+430
+00:36:46,570 --> 00:36:54,070
+بالدبحة القلبية بعد ما ينصب من 6 ل 8 ساعاتبدا الـ
+
+431
+00:36:54,070 --> 00:36:58,690
+AST يرتفع في الـ Serum يعني بيبدأ يطلع من عضلة
+
+432
+00:36:58,690 --> 00:37:04,090
+القلب ويطلع إلى الدم ويرتفع تمام؟ بيصل إلى ال
+
+433
+00:37:04,090 --> 00:37:09,730
+peaks إلى القمة يعني بيصل تركيزه لأعلى تركيز خلال
+
+434
+00:37:09,730 --> 00:37:16,930
+24 ساعة من الإصابة بالدبحة القلبية وبعد هيك بيضلوا
+
+435
+00:37:16,930 --> 00:37:23,380
+عالي في الـ Serumالـ AST بيضلوا عالي وبيرجع طبيعي
+
+436
+00:37:23,380 --> 00:37:30,560
+بعد خمس أيام من الدبحة القلبية بيرجع طبيعي بيرجع
+
+437
+00:37:30,560 --> 00:37:34,500
+تركيزه طبيعي في الـ Serum بعد خمس أيام من حدوث
+
+438
+00:37:34,500 --> 00:37:39,920
+الإصابة طبعا متى بيرتفع و متى بيصل لل peaks و متى
+
+439
+00:37:39,920 --> 00:37:44,600
+بيرجع للـ Normal Rangeهذه يعني مش حفظ بالظبط بس
+
+440
+00:37:44,600 --> 00:37:49,720
+بدنا نفهمها ASC levels are highest in acute
+
+441
+00:37:49,720 --> 00:37:53,460
+hepatocellular disorder الـ viral hepatitis
+
+442
+00:37:53,460 --> 00:37:59,840
+والسيروسز بحكي للـ ASC بيصل لأعلى تركيز له في الـ
+
+443
+00:37:59,840 --> 00:38:04,140
+Serum في حالة الـ acute hepatocellular disorder
+
+444
+00:38:04,140 --> 00:38:05,200
+الحالات
+
+445
+00:38:07,610 --> 00:38:12,330
+اللي بيصير فيها ده مش في خلايا الكبد بشكل حاد يعني
+
+446
+00:38:12,330 --> 00:38:17,090
+إنسان سليم ومافي إشي فجأة بيحكيلك عنده «acute
+
+447
+00:38:17,090 --> 00:38:22,150
+hepatocellular disorder» يعني حالة حادة بشكل مفاجئ
+
+448
+00:38:22,150 --> 00:38:27,510
+فبطه خلايا الكبد حدث فيها مشكلةبيكون سبب الـ
+
+449
+00:38:27,510 --> 00:38:31,670
+Damage اللي صار في الكبد هو الـ Viral Hepatitis
+
+450
+00:38:31,670 --> 00:38:36,650
+فيروس دخل خلايا الكبد وعمل فيها التهابات وبالتالي
+
+451
+00:38:36,650 --> 00:38:40,410
+أحدث فيها Damage لتيجة هذا الـ Damage الـ AST
+
+452
+00:38:40,410 --> 00:38:43,950
+بيطلع من خلايا الكبد إلى الدم وبالتالي بإزداد
+
+453
+00:38:43,950 --> 00:38:48,670
+تركيزه أيضًا حالات الـ Cirrhosis حالات تليف الكبد
+
+454
+00:38:48,670 --> 00:38:54,650
+برضه هيطلع الـ AST من خلايا الكبد إلى الدم ويزيد
+
+455
+00:38:54,650 --> 00:38:56,040
+تركيزهالسلام عليكم
+
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/InqN-dDPQVI_postprocess.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/InqN-dDPQVI_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..9718ee1f00d544623e914a6a22c4d1f20e2846ed
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/InqN-dDPQVI_postprocess.srt
@@ -0,0 +1,1188 @@
+1
+00:00:01,330 --> 00:00:05,730
+الـ Creatinine Clearance Test هذا فحص جديد اسمه
+
+2
+00:00:05,730 --> 00:00:11,670
+Creatinine Clearance وبرمزوله CCL Creatinine
+
+3
+00:00:11,670 --> 00:00:16,730
+Clearanceهذا الفحص يستخدم لإستناء عدد الـ
+
+4
+00:00:16,730 --> 00:00:22,210
+Glomerular Filtration أنا من خلال هذا الفحص بقدر
+
+5
+00:00:22,210 --> 00:00:29,690
+أحسب معدل فلترة الكلة بقدر أحسب وأقدر معدل فلترة
+
+6
+00:00:29,690 --> 00:00:34,570
+الكلة Glomerulus Filtrationلو سألناكم سؤال جانبي
+
+7
+00:00:34,570 --> 00:00:38,570
+شو تعريف معدل فلترة الكلة الـ glomerulus
+
+8
+00:00:38,570 --> 00:00:44,770
+filtration rate هي عبارة عن حجم الدم كمية الدم
+
+9
+00:00:44,770 --> 00:00:52,230
+اللي واصلة للكلة في الدقيقة الواحدة عشان يتم عملية
+
+10
+00:00:52,230 --> 00:00:58,640
+فلترة هذا الدم تمام؟طبعا اسم الفحص كرياتينين
+
+11
+00:00:58,640 --> 00:01:04,560
+Clearance ديش صموه بهذا الاثم لأنه تم استخدام مادة
+
+12
+00:01:04,560 --> 00:01:11,200
+الكرياتينين في هذا الفحص من أجل تقدير قيمة أو من
+
+13
+00:01:11,200 --> 00:01:19,120
+أجل تقدير معدل فالترة الكلة إذا تم استخدام مادة
+
+14
+00:01:19,120 --> 00:01:28,440
+الكرياتينين تم استخداممادة الكرياتينين من أجل حساب
+
+15
+00:01:28,440 --> 00:01:33,940
+معدل فالترة الكلة كرياتينين is it chosen يعني تم
+
+16
+00:01:33,940 --> 00:01:40,240
+اختيار الكرياتينين بالأخص في هذا الفحص عشان أحسب
+
+17
+00:01:40,240 --> 00:01:47,020
+معدل فالترة الكلةلأن كل الكرياتينين التفاجنة بيجي
+
+18
+00:01:47,020 --> 00:01:52,300
+على الكلة وبتفلتر وبعد ما يتفلتر كل الكرياتينين
+
+19
+00:01:52,300 --> 00:01:57,800
+بيصيرله execution عن طريق اليورين تمام؟ وبتطلع كله
+
+20
+00:01:57,800 --> 00:02:02,720
+برا الجسم نسبة ضئيلة جدا جدا فقط هي اللي بتضلها في
+
+21
+00:02:02,720 --> 00:02:07,800
+بلازمة الدم وما بيصيرله reabsorption ما بيصيرله
+
+22
+00:02:07,800 --> 00:02:13,960
+إعادة انتصاص عشان هيك استخدموا مادة الكرياتينينمن
+
+23
+00:02:13,960 --> 00:02:22,500
+أجل حساب معدل فالترة الكلا بدقة، تمام؟ however, a
+
+24
+00:02:22,500 --> 00:02:27,080
+small amount of the keratinin about 5% in the
+
+25
+00:02:27,080 --> 00:02:30,720
+final urine of healthy person is derived from
+
+26
+00:02:30,720 --> 00:02:35,340
+tubular secretion هذه الجملة بالتحديد بدنا نلغيها
+
+27
+00:02:35,340 --> 00:02:40,820
+وما بدنا نحكي عنها، تمام؟to do the test عشان أعمل
+
+28
+00:02:40,820 --> 00:02:45,040
+فحص الكرياتينين clearance كلمة clearance معناها
+
+29
+00:02:45,040 --> 00:02:50,780
+execution خروج التخلص من الكرياتينين كرياتينين
+
+30
+00:02:50,780 --> 00:02:56,540
+clearance معناها execution للكرياتينين هذا فحص أنا
+
+31
+00:02:56,540 --> 00:03:02,740
+من خلاله بقدر معدل فلترة الكلاه بحسب معدل فلترة
+
+32
+00:03:02,740 --> 00:03:08,480
+الكلاه تمام؟ وإيه لقالهم؟ليش استخدموا الكرياتينين
+
+33
+00:03:08,480 --> 00:03:14,820
+في القانون؟ وليش استخدموا الكرياتينين من أجل تقدير
+
+34
+00:03:14,820 --> 00:03:21,960
+معدل فالترة الكلة؟ لأن الكرياتينين فضلات، هذه
+
+35
+00:03:21,960 --> 00:03:26,400
+الفضلات كلها بتخرج و بيصيرلها clearance عن طريق
+
+36
+00:03:26,400 --> 00:03:31,980
+الكلة، برا الجسم وجزء ضئيل منه بيصيرله إعادة
+
+37
+00:03:31,980 --> 00:03:38,070
+انتصاصto do the test عشان تعمل الفحص one needs a
+
+38
+00:03:38,070 --> 00:03:41,450
+precisely timed urine collection and a blood
+
+39
+00:03:41,450 --> 00:03:45,330
+sample taken during the collection period عشان
+
+40
+00:03:45,330 --> 00:03:49,110
+تعمل فحص يعني لو إجاكي في ال request للمريض
+
+41
+00:03:49,110 --> 00:03:53,430
+curiosity in clearance عشان تعمل هذا الفحص لازم
+
+42
+00:03:53,430 --> 00:03:58,950
+تجمع من المريض عينتان عينة دم وعينة urine عينة
+
+43
+00:03:58,950 --> 00:04:05,000
+الدمبدي أفحص فيها تركيز الكرياتينين وعينة الـ
+
+44
+00:04:05,000 --> 00:04:09,700
+urine برضه بدي أفحص في الـ urine برضه الكرياتينين،
+
+45
+00:04:09,700 --> 00:04:15,700
+تمام؟ إذا عينتين، عينة serum وعينة urine في
+
+46
+00:04:15,700 --> 00:04:22,530
+العينتين بدنا نفحص تركيز الكرياتينينهذه فكرة فحص
+
+47
+00:04:22,530 --> 00:04:27,330
+الـ Creatinine Clearance وليش أنا بعمل هذا الفحص؟
+
+48
+00:04:27,330 --> 00:04:32,450
+عشان بدي أحسب معدل فلترة الكلة بدي أحسب الـ
+
+49
+00:04:32,450 --> 00:04:38,240
+Glomerular Filtration RateCreatinine Clearance
+
+50
+00:04:38,240 --> 00:04:41,340
+Pest Results are obtained from a 24-hour urine
+
+51
+00:04:41,340 --> 00:04:45,860
+collection أفضل نتيجة هو الـ 24-hour urine إن
+
+52
+00:04:45,860 --> 00:04:50,280
+المريض يجيب زجاجات ويبدأ يجمع ال urine فيها على
+
+53
+00:04:50,280 --> 00:04:54,660
+مدار الـ 24 ساعةوهذه الزجاجات اللي فيها الـ urine
+
+54
+00:04:54,660 --> 00:04:59,900
+اللي جمعها خلال 24 ساعة بياخدها على المستشفى عشان
+
+55
+00:04:59,900 --> 00:05:04,880
+يعملوله فحص الـ creatinine clearance the test is
+
+56
+00:05:04,880 --> 00:05:08,700
+initiated by having patients in pituitary bladder
+
+57
+00:05:08,700 --> 00:05:14,340
+at the beginning of the time period يعني عينة ال
+
+58
+00:05:14,340 --> 00:05:20,210
+urineبدو يجمعها على مدار الـ 24 ساعة يعني من
+
+59
+00:05:20,210 --> 00:05:25,230
+التمانية الصبح اليوم للتمانية الصبح تاني يوم هي
+
+60
+00:05:25,230 --> 00:05:31,890
+هدول 24 ساعة اليوم تمانية صباحا بصحى المريض بيكون
+
+61
+00:05:31,890 --> 00:05:36,770
+محضر الزجاجات طبعا بصحى بده يعمل urine بده يفوت
+
+62
+00:05:36,770 --> 00:05:41,320
+الحمام يعمل urineهذا الـ urine اللي بده يطلعه
+
+63
+00:05:41,320 --> 00:05:47,380
+ممنوع يحطه في الزجاجات ممنوع يحطه في الحسبة بعمله
+
+64
+00:05:47,380 --> 00:05:53,140
+تفريغ MBT وخلاص بعد هيك وجد ما يحس أنه بدي يعمل
+
+65
+00:05:53,140 --> 00:05:56,940
+urine تاني بيبدأ يحط هذا ال urine في الزجاجات
+
+66
+00:05:56,940 --> 00:06:02,470
+ويجمعه بيضلوا يجمع فيه ال urineلتاني يوم الساعة
+
+67
+00:06:02,470 --> 00:06:07,770
+تمانية الصبح تاني يوم الساعة تمانية الصبح لما
+
+68
+00:06:07,770 --> 00:06:13,610
+بيصحى برضه لما بده ييجي يفرغ ال urine تاني يوم
+
+69
+00:06:13,610 --> 00:06:18,170
+الساعة تمانية الصبح برضه ال urine في هذا الوقت
+
+70
+00:06:18,170 --> 00:06:23,070
+ممنوع برضه يحطه ضمن الحسبة ممنوع يحطه في الزجاجات
+
+71
+00:06:23,070 --> 00:06:31,680
+اللي جمع فيها بيروح يفرغه في خلاص بيفرغهوبتخلص منه
+
+72
+00:06:31,680 --> 00:06:37,660
+إذا جمع العينة 24 ساعة بيضلوا يجمع يولن من
+
+73
+00:06:37,660 --> 00:06:43,140
+التمانية صباحي اليوم للتمانية صباحي تاني يومع
+
+74
+00:06:43,140 --> 00:06:46,660
+الساعة تمانية الصبح لو حاسس بده يعمل urine ممنوع
+
+75
+00:06:46,660 --> 00:06:50,680
+ينحسب هذا ال urine ضمن الحسبة و تاني يوم كذلك
+
+76
+00:06:50,680 --> 00:06:54,940
+الساعة تمانية الصبح لو حاسس بده يعمل urine ممنوع
+
+77
+00:06:54,940 --> 00:07:03,090
+برضه هذا ال urine يتجمع وينحط في الحسبة تمام؟الـ
+
+78
+00:07:03,090 --> 00:07:07,870
+Creatinine Clearance Test طبعاً هذا الفحص له قانون
+
+79
+00:07:07,870 --> 00:07:14,190
+ومن خلال هذا القانون أنا بأحسب معدل فلترة الكلاب
+
+80
+00:07:14,190 --> 00:07:19,230
+بحسب الـ glomerulus filtration rate إذا القانون
+
+81
+00:07:19,230 --> 00:07:23,810
+نصه كالقاتي مش اللي مكتوب بالسلايدات ما بدنا
+
+82
+00:07:23,810 --> 00:07:29,510
+نستخدمه هنحكي عن القانون الشائع انه الـ Creatinine
+
+83
+00:07:29,510 --> 00:07:35,250
+Clearance إيش بيساوييساوي تركيز الكرياتينين في الـ
+
+84
+00:07:35,250 --> 00:07:40,590
+urine بالmilligram per deciliter ضرب ال volume of
+
+85
+00:07:40,590 --> 00:07:46,610
+urine بالmilliliter يعني حجم ال urine كمية ال
+
+86
+00:07:46,610 --> 00:07:51,710
+urine اللي طلعها المريض بالmilliliter على تركيز
+
+87
+00:07:51,710 --> 00:07:55,650
+الكرياتينين في ال blood بالmilligram per deciliter
+
+88
+00:07:55,650 --> 00:08:03,510
+دايق ضرب ال timeالـ Time اللي هو وقت تجميع عينة
+
+89
+00:08:03,510 --> 00:08:08,270
+اليوران الـ Time يعني 24 Hour لكن في القانون
+
+90
+00:08:08,270 --> 00:08:13,190
+بيحكيلي لازم اتحول الـ Hour إلى Minutes الساعة إلى
+
+91
+00:08:13,190 --> 00:08:20,180
+دقائق فلما أحول من ساعة لدقيقة بدرب في ستين24 ساعة
+
+92
+00:08:20,180 --> 00:08:27,680
+24 ساعة يعني الـ 24 مضروبها في 60 بطلع عندي 1440
+
+93
+00:08:27,680 --> 00:08:32,960
+minutes إذا القانون كالقاتل الـ Creatinine
+
+94
+00:08:32,960 --> 00:08:36,800
+Clearance إيش بيساوي تركيز الكرياتينين في الـ
+
+95
+00:08:36,800 --> 00:08:40,900
+urine بالmilligram per deciliter ضرب ال volume of
+
+96
+00:08:40,900 --> 00:08:46,060
+urine بالmilliliter على تركيز الكرياتينين في الـ
+
+97
+00:08:46,060 --> 00:08:50,300
+serum ضربطبعا بال milligram per deciliter ضرب ال
+
+98
+00:08:50,300 --> 00:08:56,080
+time الوقت بال minutes اللي هي ال 1440 دقيقة كانت
+
+99
+00:08:56,080 --> 00:09:01,860
+24 ساعة حولت للدقيقة ضربت ال 24 ب 60 فطلع عندي
+
+100
+00:09:01,860 --> 00:09:09,870
+1440 دقيقةدقيقة، لو جينا نشوف طبعا هذا القانون لو
+
+101
+00:09:09,870 --> 00:09:15,930
+أنا طبقته أنا هيك بطلّع معدّل فالترة الكلة بطلّع
+
+102
+00:09:15,930 --> 00:09:22,030
+معدّل فالترة الكلة طبعا الوحدة تبعت معدّل فالترة
+
+103
+00:09:22,030 --> 00:09:26,560
+الكلة من القانون بجيبهاالـ milligram تركيز
+
+104
+00:09:26,560 --> 00:09:29,680
+الكرياتينين في الـ urine بيكون بالmilligram per
+
+105
+00:09:29,680 --> 00:09:34,100
+deciliter وتركيز الكرياتينين في الدم برضه بيكون
+
+106
+00:09:34,100 --> 00:09:37,620
+بالmilligram per deciliter واحدة في البسط وواحدة
+
+107
+00:09:37,620 --> 00:09:42,180
+في المقام الوحدات بالغباط بيضل فوق عندي في البسط
+
+108
+00:09:42,180 --> 00:09:45,900
+mean بيضل ال volume of urine حجم ال urine
+
+109
+00:09:45,900 --> 00:09:53,490
+بالmilliliter علىتحت في المقام بيكون عندي الـtime
+
+110
+00:09:53,490 --> 00:10:00,590
+الوقت بالـ minutes بالدقائق إذا فعليا وحدة قياسالـ
+
+111
+00:10:00,590 --> 00:10:05,850
+Glomerulus filtration rate معدل فلترة الكيلة بالـ
+
+112
+00:10:05,850 --> 00:10:10,670
+milliliter per minute milliliter per minute وهذا
+
+113
+00:10:10,670 --> 00:10:17,630
+أصلا تعريفها حجم الدم كمية الدم بالmilliliter اللي
+
+114
+00:10:17,630 --> 00:10:23,330
+بتصل الكيلة في كل دقيقة و اللي لازمة لعملية
+
+115
+00:10:23,330 --> 00:10:30,180
+الفلترة إذا الكرياتينين clearance test هذا فحصإله
+
+116
+00:10:30,180 --> 00:10:35,700
+قانونه لو أنا طبقت القانون اللي أعطيتكم إياه هطلّع
+
+117
+00:10:35,700 --> 00:10:42,960
+معدّل فالترة الكلة تمام؟ و الوحدة تبعت القانون و
+
+118
+00:10:42,960 --> 00:10:47,660
+تبعت معدّل فالترة الكلة الناتج النهائي بيكون
+
+119
+00:10:47,660 --> 00:10:54,000
+بالmilliliter per minute تمام؟بالـ milliliter per
+
+120
+00:10:54,000 --> 00:10:56,920
+minute الـ milligram per deciliter والـ milligram
+
+121
+00:10:56,920 --> 00:11:00,740
+per deciliter ألغوا بعض فبيضل عندى فى ال bus فوق
+
+122
+00:11:00,740 --> 00:11:05,000
+بالـ milliliter وفى المقام تحت الـ time بالـ
+
+123
+00:11:05,000 --> 00:11:09,280
+minutes تمام؟ هذا بالنسبة لنص هذه ال slide هذه ال
+
+124
+00:11:09,280 --> 00:11:13,540
+slide كاتبين قانون آخر مش مستخدم كتير عندنا اللى
+
+125
+00:11:13,540 --> 00:11:18,580
+مستخدم اللى حكيتلكم عنه بنطبقه و بنطلع النتيجة
+
+126
+00:11:18,580 --> 00:11:20,940
+بالـ milliliter per minute
+
+127
+00:11:23,540 --> 00:11:27,020
+The range of creatinine clearance in healthy
+
+128
+00:11:27,020 --> 00:11:34,480
+persons corrected to a surface area of 1.73 m² is
+
+129
+00:11:34,480 --> 00:11:40,440
+90 to 120 ml per minute الـ Healthy people إحنا
+
+130
+00:11:40,440 --> 00:11:46,250
+كناس طبيعيين الـ creatinine clearance عندناأو ما
+
+131
+00:11:46,250 --> 00:11:51,130
+يسمى بالـGlomerulus Filtration Rate معدل فلترة
+
+132
+00:11:51,130 --> 00:11:58,210
+الكلاب عنا الوضع الطبيعي لازم تطلع ما بين 90 ل120
+
+133
+00:11:58,210 --> 00:12:04,260
+ملي لتر per minuteيعني حوالي في الدقيقة الواحدة
+
+134
+00:12:04,260 --> 00:12:10,800
+حجم الدم اللي بيصل الكلة من تسعين لمية وعشرين اما
+
+135
+00:12:10,800 --> 00:12:15,600
+الدم بيصل للكلة في الدقيقة الواحدة وبتم عملية
+
+136
+00:12:15,600 --> 00:12:21,740
+الفلترة لإله، تمام؟ إذا الـhealthy peopleمعدل
+
+137
+00:12:21,740 --> 00:12:28,380
+فلترة الكيلة للناس الطبيعية من 90 ل120 ملي لتر per
+
+138
+00:12:28,380 --> 00:12:34,680
+minute يعني كل دقيقة بيصل الكيلة حوالي من 90 ل120
+
+139
+00:12:34,680 --> 00:12:40,140
+أم الدم تمام، بتفلتره وبتنزل اللي ما بده هي مع ال
+
+140
+00:12:40,140 --> 00:12:45,820
+urine بتعمل Reabsorption للشغلات المهمة ال point
+
+141
+00:12:45,820 --> 00:12:50,600
+التانية، النقطة التانية ما بدنا هيها لغية تمام؟ما
+
+142
+00:12:50,600 --> 00:12:56,560
+بدنا نتطلع عليها هذه الـ slide انشرحت parallel
+
+143
+00:12:56,560 --> 00:13:00,520
+determination of urea and creatinine is performed
+
+144
+00:13:00,520 --> 00:13:03,300
+to differentiate between pre-renal and post-renal
+
+145
+00:13:03,300 --> 00:13:06,520
+azotemia لما تعمل فحص الـ urea و ال creatinine
+
+146
+00:13:06,520 --> 00:13:09,760
+التانين مع بعض بيميزه بين الحالات المرضية الـ pre
+
+147
+00:13:09,760 --> 00:13:13,160
+-renal و ال post-renal شفنا حالات لـ pre-renal
+
+148
+00:13:13,160 --> 00:13:18,700
+azotemiaهذه الحالات caused by سببها يكون عندك
+
+149
+00:13:18,700 --> 00:13:22,600
+الكيلة الطبيعية بس انها dehydration جفاف نتيجة
+
+150
+00:13:22,600 --> 00:13:27,140
+الجفاف اليوريا في البلازمة تتركز و تزيد تركيزها
+
+151
+00:13:27,140 --> 00:13:31,730
+لكن اتفاقنا الكرياتينين ما بتأثرزيادة البروتين
+
+152
+00:13:31,730 --> 00:13:35,410
+كاتابوليزم برضه هيزيد من تركيز اليوريا بس
+
+153
+00:13:35,410 --> 00:13:40,210
+الكرياتينين ما بتأثر أو قلة في الـ Renal Perfusion
+
+154
+00:13:40,210 --> 00:13:45,910
+قلة في تروية الكلة يعني كمية الدم اللي واصلة للكلة
+
+155
+00:13:45,910 --> 00:13:52,030
+قليلة جدا وبالتالي ما بيصير عندي فالترة في اليوريا
+
+156
+00:13:52,030 --> 00:13:57,930
+وبالتالي بيزيد تركيزها في الدمهذا كله هيؤد إلى
+
+157
+00:13:57,930 --> 00:14:03,210
+ارتفاع اليوريا بينما مستوى الكرياتينين يبقى ضمن
+
+158
+00:14:03,210 --> 00:14:08,370
+الـNormal Range لكن حالات الـPostrenal Azotemia
+
+159
+00:14:08,370 --> 00:14:13,110
+يعني الكيلة طبيعية لكن المشكلة في وجود حصاوي في
+
+160
+00:14:13,110 --> 00:14:17,290
+الـUrinary Tract في المسالك البولية الكيلة فالترت
+
+161
+00:14:17,290 --> 00:14:21,370
+الدم نزلت اليوريا والكرياتينين والكرياتينين بدأوا
+
+162
+00:14:21,370 --> 00:14:26,570
+يطلعوا مع الـUrineلكن لاجوا فيه عائق لسطون الحصاوي
+
+163
+00:14:26,570 --> 00:14:30,890
+وبالتالي رجعوا للدم مرة أخرى وزاد تركيزهم في الدم
+
+164
+00:14:30,890 --> 00:14:35,490
+في الـ Posternal اللي بيكون سببه Obstruction
+
+165
+00:14:35,490 --> 00:14:39,690
+انسداد في الـ Urinary Tract both يوريا وكرياتينين
+
+166
+00:14:39,690 --> 00:14:43,710
+بارتفعوا في الدمBut الكرياتينين in a smaller
+
+167
+00:14:43,710 --> 00:14:47,370
+extent طبعا التنين بيرتفعوا بس ارتفاع اليوريا
+
+168
+00:14:47,370 --> 00:14:52,090
+بيكون اكبر من ارتفاع الكرياتينين تمام؟ هاي ال
+
+169
+00:14:52,090 --> 00:14:58,640
+slide انحكى فيهاالـUric Acid المادة التالتة اللي
+
+170
+00:14:58,640 --> 00:15:03,060
+بتشيك على وظائف الكلة وهي تعتبر Non-protein
+
+171
+00:15:03,060 --> 00:15:07,400
+nitrogen substances مادة من المواد اللي بتحتوي في
+
+172
+00:15:07,400 --> 00:15:11,300
+تركيبها الداخل على الـNitrogen ولكنها لا تعتبر من
+
+173
+00:15:11,300 --> 00:15:16,400
+ضمن البروتينات Uric Acid is formedfrom the
+
+174
+00:15:16,400 --> 00:15:19,820
+breakdown of the nucleic acid الـUric Acid هو
+
+175
+00:15:19,820 --> 00:15:25,100
+فضلات جاي من تكسير الـNucleic Acid يعني لما تتكسر
+
+176
+00:15:25,100 --> 00:15:32,260
+الأحماض النووية الـDNA والـRNA نتيجة تكسيرهم بينتج
+
+177
+00:15:32,260 --> 00:15:38,870
+عنها مادة الـUric Acid تمام؟and is an end product
+
+178
+00:15:38,870 --> 00:15:44,130
+of a purine metabolism كتير من المأكلات، اللحوم،
+
+179
+00:15:44,130 --> 00:15:49,170
+الحمرة، الفول، الحمص، البقليات كلها هذه المواد
+
+180
+00:15:49,170 --> 00:15:53,150
+تحتوي على مادة الـpurine لما الإنسان بتناول هذه
+
+181
+00:15:53,150 --> 00:15:57,390
+المواد عشان يصير في استفادة من مادة الـpurine
+
+182
+00:15:57,390 --> 00:16:02,510
+بيصير metabolism لهذه المادة وتكسير نتيجة تكسير
+
+183
+00:16:02,510 --> 00:16:07,840
+مادة الـpurineاللي أصلاً هذه المادة جاية من مأكلات
+
+184
+00:16:07,840 --> 00:16:11,960
+لحم وبقليات لما بتتكسر مادة البيورين بيصير عنا
+
+185
+00:16:11,960 --> 00:16:17,480
+release لمادة الـUric Acid إذاً هي فضلات جاية من
+
+186
+00:16:17,480 --> 00:16:23,670
+تكسير الـDNA والـRNA ومادة البيورين، تمام؟Yuric
+
+187
+00:16:23,670 --> 00:16:27,690
+acid is transported by the plasma from the liver
+
+188
+00:16:27,690 --> 00:16:32,130
+to the kidney where it is filtered and where about
+
+189
+00:16:32,130 --> 00:16:38,510
+70% is executed هلجيت الـYuric acid اللي اتكون في
+
+190
+00:16:38,510 --> 00:16:43,990
+الدم، نتيجة تكسير الـDNA والـRNA والـLipurineمع
+
+191
+00:16:43,990 --> 00:16:48,490
+الدم بيجي الـ Uric Acid على الكلة عشان تصير عملية
+
+192
+00:16:48,490 --> 00:16:54,850
+الفلترة لإله و70% من الـ Uric Acid بيصيرله
+
+193
+00:16:54,850 --> 00:16:59,590
+Execration عن طريق اليورين 70% من الـ Uric Acid
+
+194
+00:16:59,590 --> 00:17:03,610
+فضلات بيطلع كله أصلا هو فضلات وسط product الـ Uric
+
+195
+00:17:03,610 --> 00:17:10,520
+Acid ف70% منه بيخرج مع اليورينتمام؟ والجثم بتخلص
+
+196
+00:17:10,520 --> 00:17:14,960
+منه The remainder of uric acid is executed into
+
+197
+00:17:14,960 --> 00:17:20,520
+the gastrointestinal tract برضه جزء من الـ uric
+
+198
+00:17:20,520 --> 00:17:26,400
+acid بيروح على منطقة الـ gastrointestinal tract
+
+199
+00:17:26,400 --> 00:17:30,860
+وبيتم خروج الـ uric acid مع الستول إذا الـ uric
+
+200
+00:17:30,860 --> 00:17:36,780
+acid بيروح على الكلاب وبيخرج 70% منه عن طريق الـ
+
+201
+00:17:36,780 --> 00:17:45,720
+urineأيضًا الـ Uric Acid بيروح في الجهاز الهضمي
+
+202
+00:17:45,720 --> 00:17:49,620
+الـ Gastrointestinal tract بيروح في هذه المناطق و
+
+203
+00:17:49,620 --> 00:17:54,140
+بيخرج مع الستول إذا بخرج مع اليورين و مع الستول و
+
+204
+00:17:54,140 --> 00:17:58,100
+بتبقى جزء بسيط جدًا من الـ Uric Acid موجود في
+
+205
+00:17:58,100 --> 00:18:02,660
+بلازمة الدم، تمام؟ إذا تركيزه في بلازمة الدم قليل
+
+206
+00:18:04,940 --> 00:18:09,840
+clinical significance أهمية الفحص disease states
+
+207
+00:18:09,840 --> 00:18:14,440
+with increased plasma uric acid حالات مرضية بزداد
+
+208
+00:18:14,440 --> 00:18:20,490
+فيها تركيز ال uric acid الجوت النقرسincreased الـ
+
+209
+00:18:20,490 --> 00:18:24,110
+catabolism of the nucleic acid يعني لما بيصير عندي
+
+210
+00:18:24,110 --> 00:18:29,030
+زيادة في تكسير ال DNA و ال RNA معنى الكلاب هيصير
+
+211
+00:18:29,030 --> 00:18:33,490
+في عندي release لـ uric acid بكميات أكبر لما بيصير
+
+212
+00:18:33,490 --> 00:18:36,750
+عندي renal disease مشكلة في الكلاب لما بيصير عندي
+
+213
+00:18:36,750 --> 00:18:40,390
+مشكلة في الكلاب الكلاب مش هتقدر ت filter ال uric
+
+214
+00:18:40,390 --> 00:18:45,290
+acid مش هتقدر تطلعه مع ال urine وبالتالي هينحجز
+
+215
+00:18:45,290 --> 00:18:49,820
+فيه الدم و يزيد تركيزهأذن تلت حلقات بيزيد فيها
+
+216
+00:18:49,820 --> 00:18:54,660
+تركيز الـUric Acid الـGout، الـRenal Disease زيادة
+
+217
+00:18:54,660 --> 00:18:58,960
+في الـCatabolism of the Nucleic Acidنشوف بالنسبة
+
+218
+00:18:58,960 --> 00:19:03,980
+لها النقرص In gout, increased serum levels of uric
+
+219
+00:19:03,980 --> 00:19:08,260
+acid lead to formation of monosodium urate
+
+220
+00:19:08,260 --> 00:19:11,920
+crystals around the joints في النقرص إيش اللي
+
+221
+00:19:11,920 --> 00:19:16,480
+بيصير؟ بيصير عندنا زيادة في الـUric Acid لما بيزيد
+
+222
+00:19:16,480 --> 00:19:21,950
+الـUric Acid في الدمبروح برتبط مع الـ Monosodium
+
+223
+00:19:21,950 --> 00:19:26,970
+برتبط مع الـ Sodium فبتكون عند الـ Crystals اسمه
+
+224
+00:19:26,970 --> 00:19:31,310
+Monosodium Urate يعني الـ Monosodium مع الـ Uric
+
+225
+00:19:31,310 --> 00:19:35,470
+Acid بربطوا مع بعض بكونوا الـ Crystals أملاح هذه
+
+226
+00:19:35,470 --> 00:19:40,610
+الـ Crystals عبارة عن أملاح هذه الأملح بتروح تترسب
+
+227
+00:19:40,610 --> 00:19:45,250
+على المفاصل تحت الجسم في الـ joint بالأخص مفاصل
+
+228
+00:19:45,250 --> 00:19:50,310
+الأقدام القدمعشان هيك مرضى النقرس دايما بنشوف
+
+229
+00:19:50,310 --> 00:19:55,210
+عندهم التهابات في المفاصل لإن الـUric Acid عندهم
+
+230
+00:19:55,210 --> 00:19:59,790
+عالي كتير في الدم فهذا الـUric Acid ربط مع الـ
+
+231
+00:19:59,790 --> 00:20:05,390
+Monosodium كون عندى أملاح اسمها Monosodium Urate
+
+232
+00:20:05,390 --> 00:20:11,970
+ترثبت في الـjoint في المفاصل وعملت التهاباتYuric
+
+233
+00:20:11,970 --> 00:20:15,490
+Acid Test is useful to assess for gout and to
+
+234
+00:20:15,490 --> 00:20:18,410
+monitor patients with renal failure اليوريك أسد
+
+235
+00:20:18,410 --> 00:20:23,910
+مهم جدا لإنقيم حالة الأشخاص اللي عندهم النقرس
+
+236
+00:20:23,910 --> 00:20:28,590
+وانتبع الناس اللي عندها مشاكل في الكلة طبعا فحص مش
+
+237
+00:20:28,590 --> 00:20:34,410
+متخصص لإنه بيزيد في حالات أخرى غير الكلة تمام؟ زي
+
+238
+00:20:34,410 --> 00:20:38,650
+و زي اليوريا عشان هيك حكينا الكرياتينين أفضل منهم
+
+239
+00:20:40,670 --> 00:20:43,930
+الـ Clinical Significance بنكمل فيها «The monitor
+
+240
+00:20:43,930 --> 00:20:46,950
+of uric acid levels are too high after
+
+241
+00:20:46,950 --> 00:20:50,850
+chemotherapy or radiation» برضه بيحكيلي الـ uric
+
+242
+00:20:50,850 --> 00:20:56,250
+acid بيكون عالي بعد ما المريض ياخد جرعة كيماوي أو
+
+243
+00:20:56,250 --> 00:21:00,030
+إشعاع ناس اللي بيكون عندها cancer سرطان بيعطوهم
+
+244
+00:21:00,030 --> 00:21:03,330
+chemotherapy كيماوي أو radiation ال chemotherapy
+
+245
+00:21:03,330 --> 00:21:08,150
+بيستهدف الخلايا بيستهدف ال DNA بيكسرواأو الـ RNA
+
+246
+00:21:08,150 --> 00:21:13,370
+تمام؟ وبالتالي محصلة تكسير الـ DNA هينتج عندنا
+
+247
+00:21:13,370 --> 00:21:18,590
+Uric Acid فبيعملوا Uric Acid دايماً لأشخاص اللي
+
+248
+00:21:18,590 --> 00:21:23,410
+بياخدوا كيموثيرابي و Radiation Hypo-uricemia
+
+249
+00:21:23,410 --> 00:21:26,970
+معناها انخفاض في مستوى الـ Uric Acid في الدم
+
+250
+00:21:26,970 --> 00:21:32,370
+السلدم هذا نادرا ما بنشوفه seldom observedيعني
+
+251
+00:21:32,370 --> 00:21:36,710
+دايمًا الـ Hyper-Euthymia هي الشائعة زيادة الـUric
+
+252
+00:21:36,710 --> 00:21:41,330
+Acid لكن الـHypo هذه حالة نادرة and associated
+
+253
+00:21:41,330 --> 00:21:44,970
+with rare hereditary metabolic disorders انخفاض
+
+254
+00:21:44,970 --> 00:21:49,830
+الـUric Acid حالات نادرة وبنشوف فيه أمراض ورسية
+
+255
+00:21:49,830 --> 00:21:54,870
+أيضًا نادرة الحدوث متعلقة في مشاكل في العمليات
+
+256
+00:21:54,870 --> 00:21:59,920
+الأيضية الـmetabolic disorder تمام؟لـ specimen لو
+
+257
+00:21:59,920 --> 00:22:03,940
+بدنا نعمل فحص الـ Uric Acid عنا Serum or إبلازمة
+
+258
+00:22:03,940 --> 00:22:07,180
+لل stability للـ Serum أو الإبلازمة 6 شهور في
+
+259
+00:22:07,180 --> 00:22:11,680
+الفريزر بنخزن العينة أو أحطها 7 أيام في التلاجة أو
+
+260
+00:22:11,680 --> 00:22:18,080
+3 أيام at room temperatureEnzymatic Calorimetric
+
+261
+00:22:18,080 --> 00:22:23,420
+طبعا مبدأ كتاتنا وطريقة العمل في الـ kit هي
+
+262
+00:22:23,420 --> 00:22:27,840
+enzymatic method و Calorimetric تمام؟ لو جينا
+
+263
+00:22:27,840 --> 00:22:32,020
+للتفاعل اللي أمامنا طبعا في عينات المريض في الـ
+
+264
+00:22:32,020 --> 00:22:35,320
+serum أو البلازما تبعه بيكون موجود الـ uric acid
+
+265
+00:22:35,320 --> 00:22:41,340
+في وجود الميه و ال oxygen و في وجود أنزايم الـ
+
+266
+00:22:41,340 --> 00:22:46,530
+uricase هذا الانزايم موجود في الـ reagentهيتفاعل
+
+267
+00:22:46,530 --> 00:22:51,950
+مع الـ Uric Acid ويكسّره ويعطينا مادة زائد CO2 و
+
+268
+00:22:51,950 --> 00:22:56,790
+Hydrogen Peroxide هلجيت الـ Hydrogen Peroxide مع
+
+269
+00:22:56,790 --> 00:23:01,010
+مادة أخرى موجودة في الـ Reagent اسمها الـ
+
+270
+00:23:01,010 --> 00:23:06,470
+Aminofenazone في محصلة الـ reaction هتتكون مادة
+
+271
+00:23:06,470 --> 00:23:12,580
+لكل من و تلت جزيئات ميّه إذا الفكرةالـReagent
+
+272
+00:23:12,580 --> 00:23:16,740
+والـUric Acid الموجودة في الـPatient Serum لما
+
+273
+00:23:16,740 --> 00:23:21,520
+بنخلطهم على بعض محصلة الـReaction تكوين لون وشدة
+
+274
+00:23:21,520 --> 00:23:26,100
+اللون تتناسب تناسب تردي مع تركيز الـUric Acid في
+
+275
+00:23:26,100 --> 00:23:30,820
+العينة، تمام؟ إذا نفس الشغل الـLipid Profile
+
+276
+00:23:30,820 --> 00:23:37,160
+والبروتينات والجلوكوز نفس الفكرةالبروسيجر يا جماعة
+
+277
+00:23:37,160 --> 00:23:41,280
+بسيطة جدا بنجيب تلاتة أنبيب بلانك standard sample
+
+278
+00:23:41,280 --> 00:23:44,920
+بنعملهم labeling تمام؟ بتجيب ال reaction تبع ال
+
+279
+00:23:44,920 --> 00:23:48,820
+kit بتاخد واحد أمقال بتحطيها في كل أمبوبة علبة ال
+
+280
+00:23:48,820 --> 00:23:52,080
+standard بيكون مكتوب عليها تركيز ال uric acid تاخد
+
+281
+00:23:52,080 --> 00:23:55,280
+منها 25 مايكرون بتحطيها في أمبوبة ال standard
+
+282
+00:23:55,280 --> 00:23:58,830
+بتعملي mix منيحبتجيب الـ Patient سيرم أو بلازمة
+
+283
+00:23:58,830 --> 00:24:03,410
+بتاخد منه 25 مايكرون وبتحطيهم في عينة الـ Sample
+
+284
+00:24:03,410 --> 00:24:06,590
+تبع الـ Patient، الأنبوبة، بتعمل الـ Mix و25
+
+285
+00:24:06,590 --> 00:24:09,550
+مايكرون من الـ Distilled Water بتاخديها وبتحطيها
+
+286
+00:24:09,550 --> 00:24:13,670
+في الـ Blank وبتعمل الـ Mix Incubation للتلت أنبيب
+
+287
+00:24:13,670 --> 00:24:17,570
+15 دقيقة at room temperature أو 10 دقائق على الـ
+
+288
+00:24:17,570 --> 00:24:24,310
+Water bath ع 37 نضبط الجهاز على 550 نانومتر وبنصفر
+
+289
+00:24:24,310 --> 00:24:28,970
+الجهاز على الـ Blankوبعدها بنحط الـ standard و
+
+290
+00:24:28,970 --> 00:24:32,170
+بناخد ال absorbance تبعه وبعدين بنحط ال sample و
+
+291
+00:24:32,170 --> 00:24:35,610
+بناخد ال absorbance تبعه و بنطبق Beer's law و
+
+292
+00:24:35,610 --> 00:24:40,250
+بنحسب تركيز ال uric acid ال normal range من 4 ل 6
+
+293
+00:24:40,250 --> 00:24:44,350
+milligram per deciliter ال color بيحكيلي بيضلوا
+
+294
+00:24:44,350 --> 00:24:48,960
+stable تلاتين دقيقة، اذا الوحدة القياسللـUrea
+
+295
+00:24:48,960 --> 00:24:51,840
+والكرياتين والـUric Acid بالـ milligram per
+
+296
+00:24:51,840 --> 00:24:56,400
+deciliter وبهيك بنكون خلصنا شبترنا لليوم يعطيكم
+
+297
+00:24:56,400 --> 00:24:57,320
+ألف عافية
+
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/Llr1MX6sqCo_raw.json b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/Llr1MX6sqCo_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..0666d2cdfd19281d3d8844c9ec190ef45d367e5f
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/Llr1MX6sqCo_raw.json
@@ -0,0 +1 @@
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"word": "%", "probability": 0.99169921875}, {"start": 187.5, "end": 188.12, "word": " من", "probability": 0.98974609375}, {"start": 188.12, "end": 188.36, "word": " الـ", "probability": 0.953857421875}, {"start": 188.36, "end": 188.76, "word": " Total", "probability": 0.888671875}, {"start": 188.76, "end": 189.82, "word": " CK،", "probability": 0.79638671875}, {"start": 189.82, "end": 190.44, "word": " تمام؟", "probability": 0.9708658854166666}], "temperature": 1.0}, {"id": 10, "seek": 19461, "start": 193.05, "end": 194.61, "text": "CK-ISO-ENZYMES�", "tokens": [9419, 12, 2343, 46, 12, 2195, 26888, 44, 2358, 171, 119, 123, 171, 119, 123, 171, 119, 123, 171, 119, 123, 171, 119, 123, 171, 119, 123, 171, 119, 123, 171, 119, 123, 171, 119, 123, 171, 119, 123, 171, 119, 123, 171, 119, 123, 171, 119, 123, 171, 119, 123, 171, 119, 123, 171, 119, 123, 171, 119, 123, 171, 119, 123, 171, 119, 123, 171, 119, 123, 171, 119, 123, 171, 119, 123, 171, 119, 123, 171, 119, 123, 171, 119, 123, 171, 119, 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1.0}, {"id": 11, "seek": 25129, "start": 221.79, "end": 251.29, "text": "حكينا الـ CKMB اللي هو CK2 لإنه مهم مهم وبيشيك على وضع عضلة القلب حكينا فيه إله كيت خاص فيه بقيس تركيزه calculation of relative index CKMB mass assay على ال total CK ضرب 100% may be used as indicator of myocardial infarction هذا الكلام حكيته", "tokens": [5016, 4117, 1829, 8315, 2423, 39184, 383, 42, 47554, 13672, 1829, 31439, 383, 42, 17, 5296, 28814, 1863, 3224, 3714, 16095, 3714, 16095, 4032, 21292, 8592, 1829, 4117, 15844, 4032, 11242, 3615, 6225, 11242, 37977, 25062, 46152, 11331, 4117, 1829, 8315, 8978, 3224, 11933, 43761, 9122, 36081, 16490, 33546, 8978, 3224, 4724, 38436, 3794, 6055, 31747, 1829, 11622, 3224, 17108, 295, 4972, 8186, 383, 42, 47554, 2758, 1256, 320, 15844, 2423, 3217, 383, 42, 48812, 25513, 2319, 4, 815, 312, 1143, 382, 16961, 295, 452, 905, 515, 831, 1536, 289, 882, 23758, 2423, 28820, 10943, 11331, 4117, 36081, 3224], "avg_logprob": -0.1704687447845936, "compression_ratio": 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عملوا قانون اسمه Relative Index إيش بيثاوي بتجسم تركيز الـCKMB تركيز هذا الـEnzyme على تركيز الـTotalCK كله درب 100%", "tokens": [7435, 16758, 14407, 6225, 42213, 14407, 12174, 7649, 11536, 24525, 2304, 3224, 8738, 1166, 33552, 11933, 1829, 8592, 4724, 1829, 12984, 995, 45865, 39894, 7435, 38251, 6055, 31747, 1829, 11622, 2423, 39184, 9419, 47554, 6055, 31747, 1829, 11622, 23758, 2423, 39184, 16257, 1229, 1398, 15844, 6055, 31747, 1829, 11622, 2423, 39184, 51, 38180, 9419, 28242, 3224, 11778, 25513, 2319, 4], "avg_logprob": -0.24231556986199052, "compression_ratio": 1.256578947368421, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 251.77, "end": 252.83, "word": "جابوا", "probability": 0.69775390625}, {"start": 252.83, "end": 253.23, "word": " عملوا", "probability": 0.9265950520833334}, {"start": 253.23, "end": 253.67, "word": " قانون", "probability": 0.97265625}, {"start": 253.67, "end": 255.17, "word": " اسمه", "probability": 0.8741861979166666}, {"start": 255.17, 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"end": 265.39, "word": " الـTotalCK", "probability": 0.8373046875}, {"start": 265.39, "end": 266.33, "word": " كله", "probability": 0.882568359375}, {"start": 266.33, "end": 266.83, "word": " درب", "probability": 0.76904296875}, {"start": 266.83, "end": 267.37, "word": " 100", "probability": 0.625}, {"start": 267.37, "end": 267.89, "word": "%", "probability": 0.85791015625}], "temperature": 1.0}, {"id": 13, "seek": 28666, "start": 268.5, "end": 286.66, "text": "حكينا لو طلعت النتيجة أقل من 6% هذا indication إن الإنسان سليم لو طلعت النتيجة أعلى من 6% معناه هذا احتمال يكون عنده acute myocardial infarction دبح قلبية، تمام؟", "tokens": [5016, 4117, 1829, 8315, 45164, 23032, 1211, 34268, 28239, 31371, 7435, 3660, 5551, 4587, 1211, 9154, 1386, 4, 23758, 18877, 36145, 33688, 1863, 3794, 7649, 8608, 20292, 2304, 45164, 23032, 1211, 34268, 28239, 31371, 7435, 3660, 5551, 3615, 23942, 9154, 1386, 4, 20449, 8315, 3224, 23758, 1975, 33753, 2304, 6027, 7251, 30544, 43242, 3224, 24390, 452, 905, 515, 831, 1536, 289, 882, 11778, 49628, 12174, 46152, 10632, 12399, 46811, 10943, 22807], "avg_logprob": -0.1019422731672724, "compression_ratio": 1.4912280701754386, "no_speech_prob": 0.0, "words": [{"start": 268.5, "end": 268.96, "word": "حكينا", "probability": 0.9415283203125}, {"start": 268.96, "end": 269.18, "word": " لو", "probability": 0.9189453125}, {"start": 269.18, "end": 269.66, "word": " طلعت", "probability": 0.9886067708333334}, {"start": 269.66, "end": 270.38, "word": " النتيجة", "probability": 0.979736328125}, {"start": 270.38, "end": 270.92, "word": " أقل", "probability": 0.9288736979166666}, {"start": 270.92, "end": 271.14, "word": " من", "probability": 0.98876953125}, {"start": 271.14, "end": 271.56, "word": " 6", "probability": 0.97900390625}, {"start": 271.56, "end": 272.14, "word": "%", "probability": 0.90185546875}, {"start": 272.14, "end": 272.82, "word": " هذا", "probability": 0.587890625}, {"start": 272.82, "end": 273.66, "word": " indication", "probability": 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279.58, "end": 280.4, "word": " احتمال", "probability": 0.9442138671875}, {"start": 280.4, "end": 280.9, "word": " يكون", "probability": 0.98876953125}, {"start": 280.9, "end": 282.0, "word": " عنده", "probability": 0.99365234375}, {"start": 282.0, "end": 282.56, "word": " acute", "probability": 0.52587890625}, {"start": 282.56, "end": 283.84, "word": " myocardial", "probability": 0.9815673828125}, {"start": 283.84, "end": 284.72, "word": " infarction", "probability": 0.9427083333333334}, {"start": 284.72, "end": 285.2, "word": " دبح", "probability": 0.752685546875}, {"start": 285.2, "end": 286.1, "word": " قلبية،", "probability": 0.8690185546875}, {"start": 286.1, "end": 286.66, "word": " تمام؟", "probability": 0.9737955729166666}], "temperature": 1.0}, {"id": 14, "seek": 31572, "start": 286.96, "end": 315.72, "text": "الـ Relative Index هذه القوانين تسمح بالفرق بين إزالة الـ Total CK بسبب إزالة الـ Myocardial Damage و بسبب إزالة الـ Skeletal أو الـ Neural Damage يعني أنا من خلال هذا القانون بقدر أعرف هل الشخص عنده Myocardial Damage مشكلة بعضلة القلب ولا مشاكل في العضلات الهيكلية أو في الدماغ، تمام؟", "tokens": [6027, 39184, 8738, 1166, 33552, 29538, 25062, 2407, 7649, 9957, 6055, 38251, 5016, 20666, 5172, 2288, 4587, 49374, 11933, 11622, 6027, 3660, 2423, 39184, 23170, 383, 42, 4724, 35457, 3555, 11933, 11622, 6027, 3660, 2423, 39184, 1222, 905, 515, 831, 5885, 609, 4032, 4724, 35457, 3555, 11933, 11622, 6027, 3660, 2423, 39184, 32344, 2631, 304, 34051, 2423, 39184, 1734, 1807, 5885, 609, 37495, 22653, 41850, 9154, 16490, 1211, 6027, 23758, 25062, 7649, 11536, 4724, 28543, 2288, 5551, 3615, 28480, 8032, 1211, 25124, 9778, 9381, 43242, 3224, 1222, 905, 515, 831, 5885, 609, 37893, 28820, 3660, 45030, 11242, 37977, 25062, 46152, 49429, 37893, 995, 28820, 8978, 18863, 11242, 1211, 9307, 2423, 3224, 1829, 28820, 10632, 34051, 8978, 32748, 2304, 5718, 118, 12399, 46811, 10943, 22807], "avg_logprob": -0.27074998569488523, "compression_ratio": 1.7297297297297298, 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{"start": 401.82, "end": 402.38, "word": " و", "probability": 0.91162109375}, {"start": 402.38, "end": 402.96, "word": " ال", "probability": 0.828125}, {"start": 402.96, "end": 403.22, "word": " B", "probability": 0.87109375}, {"start": 403.22, "end": 403.62, "word": " ال", "probability": 0.72314453125}, {"start": 403.62, "end": 403.92, "word": " M", "probability": 0.9716796875}, {"start": 403.92, "end": 404.56, "word": " حكينا", "probability": 0.9744873046875}, {"start": 404.56, "end": 405.2, "word": " راجعة", "probability": 0.92822265625}, {"start": 405.2, "end": 405.36, "word": " من", "probability": 0.98681640625}, {"start": 405.36, "end": 405.74, "word": " كلمة", "probability": 0.9894205729166666}, {"start": 405.74, "end": 406.08, "word": " muscle", "probability": 0.755859375}, {"start": 406.08, "end": 406.42, "word": " و", "probability": 0.568359375}, {"start": 406.42, "end": 406.54, "word": " ال", "probability": 0.927734375}, {"start": 406.54, "end": 406.76, "word": " B", "probability": 0.9765625}, {"start": 406.76, "end": 407.36, "word": " راجعة", "probability": 0.984375}, {"start": 407.36, "end": 407.58, "word": " من", "probability": 0.9921875}, {"start": 407.58, "end": 408.36, "word": " كلمة", "probability": 0.9925130208333334}, {"start": 408.36, "end": 408.84, "word": " brain", "probability": 0.75634765625}], "temperature": 1.0}, {"id": 19, "seek": 43167, "start": 409.27, "end": 431.67, "text": "فعلياً هدول عبارة عن الـ enzyme عبارة عن البروتينات كلنا عارفين تركبتها البروتينات أحماض أمينية سلاسل بيبتدية فالـ M و الـ B هدى لرموز أطلقوها على السلاسل البيبتدية يعني لما بحكي CK1 عبارة عن شو؟", "tokens": [5172, 3615, 20292, 995, 14111, 8032, 3215, 12610, 6225, 3555, 9640, 3660, 18871, 2423, 39184, 24521, 6225, 3555, 9640, 3660, 18871, 2423, 26890, 35473, 9957, 9307, 28242, 8315, 6225, 9640, 5172, 9957, 6055, 31747, 3555, 2655, 11296, 2423, 26890, 35473, 9957, 9307, 5551, 35571, 46958, 5551, 2304, 9957, 10632, 8608, 15040, 3794, 1211, 4724, 1829, 3555, 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عبارة", "probability": 0.981689453125}, {"start": 413.47, "end": 413.61, "word": " عن", "probability": 0.99462890625}, {"start": 413.61, "end": 414.23, "word": " البروتينات", "probability": 0.865625}, {"start": 414.23, "end": 414.59, "word": " كلنا", "probability": 0.779052734375}, {"start": 414.59, "end": 414.93, "word": " عارفين", "probability": 0.9898681640625}, {"start": 414.93, "end": 415.61, "word": " تركبتها", "probability": 0.96552734375}, {"start": 415.61, "end": 416.35, "word": " البروتينات", "probability": 0.93583984375}, {"start": 416.35, "end": 416.87, "word": " أحماض", "probability": 0.8707682291666666}, {"start": 416.87, "end": 417.57, "word": " أمينية", "probability": 0.823974609375}, {"start": 417.57, "end": 418.57, "word": " سلاسل", "probability": 0.8577880859375}, {"start": 418.57, "end": 419.39, "word": " بيبتدية", "probability": 0.7909342447916666}, {"start": 419.39, "end": 420.69, "word": " فالـ", "probability": 0.7970377604166666}, {"start": 420.69, "end": 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بحكي", "probability": 0.9542236328125}, {"start": 428.69, "end": 430.07, "word": " CK1", "probability": 0.7049153645833334}, {"start": 430.07, "end": 430.85, "word": " عبارة", "probability": 0.9945068359375}, {"start": 430.85, "end": 431.05, "word": " عن", "probability": 0.99267578125}, {"start": 431.05, "end": 431.67, "word": " شو؟", "probability": 0.9484049479166666}], "temperature": 1.0}, {"id": 20, "seek": 45763, "start": 432.17, "end": 457.63, "text": "الـ CK1 عبارة عن BB يعني هذا الـ Isoenzyme بيحتوي على two polypeptide H2 سلسلتين من السلاسل البيبتدية كل سلسلة بيسموها B تمام؟ لما أحكي CK2 يعني CKMB يعني هذا الـ Isoenzyme بتكون من two polypeptide من سلسلتين", "tokens": [6027, 39184, 383, 42, 16, 6225, 3555, 9640, 3660, 18871, 19168, 37495, 22653, 23758, 2423, 39184, 286, 539, 268, 1229, 1398, 4724, 1829, 33753, 45865, 15844, 732, 6754, 494, 662, 482, 389, 17, 8608, 1211, 3794, 1211, 2655, 9957, 9154, 21136, 15040, 3794, 1211, 2423, 21292, 3555, 2655, 3215, 10632, 28242, 8608, 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{"start": 435.45, "end": 435.73, "word": " الـ", "probability": 0.93212890625}, {"start": 435.73, "end": 436.69, "word": " Isoenzyme", "probability": 0.825}, {"start": 436.69, "end": 437.59, "word": " بيحتوي", "probability": 0.83831787109375}, {"start": 437.59, "end": 437.95, "word": " على", "probability": 0.919921875}, {"start": 437.95, "end": 438.63, "word": " two", "probability": 0.478759765625}, {"start": 438.63, "end": 439.91, "word": " polypeptide", "probability": 0.8470458984375}, {"start": 439.91, "end": 440.55, "word": " H2", "probability": 0.51025390625}, {"start": 440.55, "end": 441.65, "word": " سلسلتين", "probability": 0.8753255208333334}, {"start": 441.65, "end": 442.55, "word": " من", "probability": 0.99072265625}, {"start": 442.55, "end": 443.31, "word": " السلاسل", "probability": 0.9381103515625}, {"start": 443.31, "end": 444.35, "word": " البيبتدية", "probability": 0.6979166666666666}, {"start": 444.35, "end": 444.91, "word": " كل", "probability": 0.8427734375}, {"start": 444.91, "end": 445.39, "word": " سلسلة", "probability": 0.9954833984375}, {"start": 445.39, "end": 446.05, "word": " بيسموها", "probability": 0.98193359375}, {"start": 446.05, "end": 446.37, "word": " B", "probability": 0.72265625}, {"start": 446.37, "end": 447.41, "word": " تمام؟", "probability": 0.6993001302083334}, {"start": 447.41, "end": 447.59, "word": " لما", "probability": 0.874755859375}, {"start": 447.59, "end": 448.01, "word": " أحكي", "probability": 0.9071044921875}, {"start": 448.01, "end": 449.21, "word": " CK2", "probability": 0.9049479166666666}, {"start": 449.21, "end": 449.95, "word": " يعني", "probability": 0.91162109375}, {"start": 449.95, "end": 451.39, "word": " CKMB", "probability": 0.7980143229166666}, {"start": 451.39, "end": 452.17, "word": " يعني", "probability": 0.952392578125}, {"start": 452.17, "end": 452.51, "word": " هذا", "probability": 0.96435546875}, {"start": 452.51, "end": 452.71, "word": " الـ", "probability": 0.848388671875}, {"start": 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"end": 828.78, "word": "-subunit", "probability": 0.7275390625}, {"start": 828.78, "end": 829.06, "word": " of", "probability": 0.712890625}, {"start": 829.06, "end": 829.68, "word": " CKB", "probability": 0.822265625}, {"start": 829.68, "end": 830.1, "word": " برضه", "probability": 0.7557779947916666}, {"start": 830.1, "end": 830.2, "word": " الـ", "probability": 0.753662109375}, {"start": 830.2, "end": 830.68, "word": " antibody", "probability": 0.43310546875}, {"start": 830.68, "end": 831.6, "word": " بشبك", "probability": 0.8973388671875}, {"start": 831.6, "end": 831.84, "word": " مع", "probability": 0.9833984375}, {"start": 831.84, "end": 832.54, "word": " الـ", "probability": 0.865478515625}, {"start": 832.54, "end": 832.72, "word": " M", "probability": 0.91796875}, {"start": 832.72, "end": 833.5, "word": "-subunit", "probability": 0.92724609375}, {"start": 833.5, "end": 833.82, "word": " اللي", "probability": 0.924560546875}, {"start": 833.82, "end": 833.98, "word": " في", "probability": 0.900390625}, {"start": 833.98, "end": 834.9, "word": " CK2", "probability": 0.8487955729166666}, {"start": 834.9, "end": 836.12, "word": " وبالتالي", "probability": 0.9421875}, {"start": 836.12, "end": 836.66, "word": " هذا", "probability": 0.82958984375}, {"start": 836.66, "end": 836.86, "word": " الـ", "probability": 0.57928466796875}, {"start": 836.86, "end": 837.3, "word": " enzyme", "probability": 0.90966796875}, {"start": 837.3, "end": 838.1, "word": " نصه", "probability": 0.92138671875}, {"start": 838.1, "end": 838.48, "word": " بيصير", "probability": 0.9405517578125}, {"start": 838.48, "end": 839.02, "word": " شغال", "probability": 0.9812825520833334}, {"start": 839.02, "end": 839.42, "word": " بيصير", "probability": 0.948974609375}, {"start": 839.42, "end": 839.9, "word": " اسمه", "probability": 0.943359375}, {"start": 839.9, "end": 840.54, "word": " CKB", "probability": 0.92626953125}, {"start": 840.54, "end": 841.32, "word": " الـ", "probability": 0.84423828125}, {"start": 841.32, "end": 841.48, "word": " M", "probability": 0.8857421875}, {"start": 841.48, "end": 841.96, "word": " خلاص", "probability": 0.98095703125}, {"start": 841.96, "end": 842.28, "word": " صار", "probability": 0.6849365234375}, {"start": 842.28, "end": 842.58, "word": " لها", "probability": 0.75634765625}, {"start": 842.58, "end": 843.4, "word": " inhibition", "probability": 0.767578125}, {"start": 843.4, "end": 844.46, "word": " and", "probability": 0.513671875}, {"start": 844.46, "end": 844.74, "word": " this", "probability": 0.9482421875}, {"start": 844.74, "end": 845.22, "word": " allowed", "probability": 0.8349609375}, {"start": 845.22, "end": 846.12, "word": " determination", "probability": 0.71875}, {"start": 846.12, "end": 846.66, "word": " of", "probability": 0.94970703125}, {"start": 846.66, "end": 846.94, "word": " the", "probability": 0.6689453125}, {"start": 846.94, "end": 847.18, "word": " B", "probability": 0.958984375}, {"start": 847.18, "end": 847.84, "word": "-subunit", "probability": 0.95068359375}, {"start": 847.84, "end": 848.16, "word": " of", "probability": 0.96142578125}, {"start": 848.16, "end": 848.98, "word": " CKB", "probability": 0.9723307291666666}, {"start": 848.98, "end": 849.48, "word": " عشان", "probability": 0.9597981770833334}, {"start": 849.48, "end": 849.8, "word": " هيك", "probability": 0.8740234375}, {"start": 849.8, "end": 850.28, "word": " فقط", "probability": 0.9931640625}, {"start": 850.28, "end": 850.88, "word": " اللي", "probability": 0.970703125}, {"start": 850.88, "end": 851.28, "word": " هيتم", "probability": 0.73974609375}, {"start": 851.28, "end": 852.04, "word": " قياسه", "probability": 0.9156494140625}, {"start": 852.04, "end": 852.86, "word": " هو", "probability": 0.96435546875}, {"start": 852.86, "end": 853.74, "word": " CKB", "probability": 0.90673828125}], "temperature": 1.0}, {"id": 38, "seek": 86961, "start": 854.73, "end": 869.61, "text": "أما الـ M صار لها Inhibition تمام؟ افترضنا إن الـ CKB بي مش موجود في بلازمة الدم وكله موجود في الـ Brain الـ CKB هذا نص الإنزايم", "tokens": [10721, 15042, 2423, 39184, 376, 20328, 9640, 5296, 11296, 682, 5455, 849, 46811, 10943, 22807, 1975, 5172, 2655, 43042, 8315, 36145, 2423, 39184, 383, 42, 33, 4724, 1829, 37893, 3714, 29245, 23328, 8978, 4724, 1211, 31377, 46007, 32748, 2304, 4032, 28820, 3224, 3714, 29245, 23328, 8978, 2423, 39184, 29783, 2423, 39184, 383, 42, 33, 23758, 8717, 9381, 33688, 1863, 11622, 995, 32640], "avg_logprob": -0.23995535193927706, "compression_ratio": 1.4246575342465753, "no_speech_prob": 0.0, "words": [{"start": 854.73, "end": 855.23, "word": "أما", "probability": 0.779296875}, {"start": 855.23, "end": 855.77, "word": " الـ", "probability": 0.7061767578125}, {"start": 855.77, "end": 855.95, "word": " M", "probability": 0.71923828125}, {"start": 855.95, "end": 856.23, "word": " صار", "probability": 0.721435546875}, {"start": 856.23, "end": 856.51, "word": " لها", "probability": 0.791015625}, {"start": 856.51, "end": 857.33, "word": " Inhibition", "probability": 0.77001953125}, {"start": 857.33, "end": 859.31, "word": " تمام؟", "probability": 0.615478515625}, {"start": 859.31, "end": 860.09, "word": " افترضنا", "probability": 0.9681640625}, {"start": 860.09, "end": 860.39, "word": " إن", "probability": 0.572265625}, {"start": 860.39, "end": 860.65, "word": " الـ", "probability": 0.86962890625}, {"start": 860.65, "end": 861.23, "word": " CKB", "probability": 0.7849934895833334}, {"start": 861.23, "end": 861.51, "word": " بي", "probability": 0.611572265625}, {"start": 861.51, "end": 862.01, "word": " مش", "probability": 0.6826171875}, {"start": 862.01, "end": 862.51, "word": " موجود", "probability": 0.98486328125}, {"start": 862.51, "end": 862.67, "word": " في", "probability": 0.83642578125}, {"start": 862.67, "end": 863.21, "word": " بلازمة", "probability": 0.77880859375}, {"start": 863.21, "end": 863.53, "word": " الدم", "probability": 0.985107421875}, {"start": 863.53, "end": 864.17, "word": " وكله", "probability": 0.8258463541666666}, {"start": 864.17, "end": 864.69, "word": " موجود", "probability": 0.98828125}, {"start": 864.69, "end": 864.99, "word": " في", "probability": 0.9658203125}, {"start": 864.99, "end": 865.47, "word": " الـ", "probability": 0.763671875}, {"start": 865.47, "end": 865.75, "word": " Brain", "probability": 0.6826171875}, {"start": 865.75, "end": 867.15, "word": " الـ", "probability": 0.85546875}, {"start": 867.15, "end": 867.87, "word": " CKB", "probability": 0.8937174479166666}, {"start": 867.87, "end": 868.35, "word": " هذا", "probability": 0.440673828125}, {"start": 868.35, "end": 868.73, "word": " نص", "probability": 0.864501953125}, {"start": 868.73, "end": 869.61, "word": " الإنزايم", "probability": 0.80439453125}], "temperature": 1.0}, {"id": 39, "seek": 89741, "start": 870.41, "end": 897.41, "text": "Catalytic concentration which corresponds to half of CKNB concentration هو فعليا نص تركيز الإنزايم ككل is determined from the rate of NADPH formation measured at 340 إذا أنا فعليا قصت نص تركيز الإنزايم بدرب النتيجة النهائية اللي بتطلع معايا ب2 عشان يطلعلي تركيز الإنزايم الكل تمام؟", "tokens": [34, 40478, 43658, 9856, 597, 23249, 281, 1922, 295, 383, 42, 45, 33, 9856, 31439, 6156, 3615, 20292, 995, 8717, 9381, 6055, 31747, 1829, 11622, 33688, 1863, 11622, 995, 32640, 9122, 28820, 307, 9540, 490, 264, 3314, 295, 426, 6112, 21904, 11723, 12690, 412, 805, 5254, 11933, 15730, 41850, 6156, 3615, 20292, 995, 12174, 9381, 2655, 8717, 9381, 6055, 31747, 1829, 11622, 33688, 1863, 11622, 995, 32640, 47525, 25513, 28239, 31371, 7435, 3660, 28239, 3224, 16373, 10632, 13672, 1829, 39894, 9566, 1211, 3615, 20449, 995, 25528, 4724, 17, 6225, 8592, 7649, 7251, 9566, 1211, 3615, 20292, 6055, 31747, 1829, 11622, 33688, 1863, 11622, 995, 32640, 2423, 28820, 46811, 10943, 22807], "avg_logprob": -0.1927083341388015, "compression_ratio": 1.5912698412698412, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 870.41, "end": 871.17, "word": "Catalytic", "probability": 0.6678873697916666}, {"start": 871.17, "end": 872.41, "word": " concentration", "probability": 0.51220703125}, {"start": 872.41, "end": 873.03, "word": " which", "probability": 0.62841796875}, {"start": 873.03, "end": 873.89, "word": " corresponds", "probability": 0.6748046875}, {"start": 873.89, "end": 874.25, "word": " to", "probability": 0.95263671875}, {"start": 874.25, "end": 874.71, "word": " half", "probability": 0.6689453125}, {"start": 874.71, "end": 875.11, "word": " of", "probability": 0.9638671875}, {"start": 875.11, "end": 875.91, "word": " CKNB", "probability": 0.608856201171875}, {"start": 875.91, "end": 876.75, "word": " concentration", "probability": 0.89990234375}, {"start": 876.75, "end": 876.99, "word": " هو", "probability": 0.763671875}, {"start": 876.99, "end": 877.55, "word": " فعليا", "probability": 0.863037109375}, {"start": 877.55, "end": 877.97, "word": " نص", "probability": 0.9384765625}, {"start": 877.97, "end": 878.69, "word": " تركيز", "probability": 0.9580078125}, {"start": 878.69, "end": 879.41, "word": " الإنزايم", "probability": 0.7923828125}, {"start": 879.41, "end": 879.99, "word": " ككل", "probability": 0.9453125}, {"start": 879.99, "end": 880.93, "word": " is", "probability": 0.62890625}, {"start": 880.93, "end": 881.73, "word": " determined", "probability": 0.9462890625}, {"start": 881.73, "end": 882.27, "word": " from", "probability": 0.92822265625}, {"start": 882.27, "end": 882.59, "word": " the", "probability": 0.8779296875}, {"start": 882.59, "end": 882.85, "word": " rate", "probability": 0.939453125}, {"start": 882.85, "end": 883.07, "word": " of", "probability": 0.9736328125}, {"start": 883.07, "end": 883.69, "word": " NADPH", "probability": 0.5807291666666666}, {"start": 883.69, "end": 884.33, "word": " formation", "probability": 0.93408203125}, {"start": 884.33, "end": 885.03, "word": " measured", "probability": 0.86376953125}, {"start": 885.03, "end": 885.45, "word": " at", "probability": 0.95751953125}, {"start": 885.45, "end": 886.47, "word": " 340", "probability": 0.86083984375}, {"start": 886.47, "end": 886.77, "word": " إذا", "probability": 0.554443359375}, {"start": 886.77, "end": 887.05, "word": " أنا", "probability": 0.8740234375}, {"start": 887.05, "end": 887.57, "word": " فعليا", "probability": 0.962646484375}, {"start": 887.57, "end": 888.09, "word": " قصت", "probability": 0.8165690104166666}, {"start": 888.09, "end": 888.57, "word": " نص", "probability": 0.990234375}, {"start": 888.57, "end": 889.19, "word": " تركيز", "probability": 0.9935302734375}, {"start": 889.19, "end": 889.81, "word": " الإنزايم", "probability": 0.9802734375}, {"start": 889.81, "end": 890.63, "word": " بدرب", "probability": 0.52392578125}, {"start": 890.63, "end": 891.53, "word": " النتيجة", "probability": 0.9676513671875}, {"start": 891.53, "end": 891.97, "word": " النهائية", "probability": 0.9832763671875}, {"start": 891.97, "end": 892.09, "word": " اللي", "probability": 0.844970703125}, {"start": 892.09, "end": 892.51, "word": " بتطلع", "probability": 0.9638671875}, {"start": 892.51, "end": 892.81, "word": " معايا", "probability": 0.7770182291666666}, {"start": 892.81, "end": 893.25, "word": " ب2", "probability": 0.5526123046875}, {"start": 893.25, "end": 893.93, "word": " عشان", "probability": 0.9794921875}, {"start": 893.93, "end": 894.45, "word": " يطلعلي", "probability": 0.94326171875}, {"start": 894.45, "end": 895.05, "word": " تركيز", "probability": 0.9962158203125}, {"start": 895.05, "end": 895.81, "word": " الإنزايم", "probability": 0.98017578125}, {"start": 895.81, "end": 896.47, "word": " الكل", "probability": 0.783203125}, {"start": 896.47, "end": 897.41, "word": " تمام؟", "probability": 0.755615234375}], "temperature": 1.0}, {"id": 40, "seek": 90670, "start": 897.68, "end": 906.7, "text": "هذه فكرة الـ Kit اللي بيقيص الـ Isoenzyme CK2 أو الاسم الآخر له CKMB", "tokens": [3224, 24192, 6156, 4117, 25720, 2423, 39184, 23037, 13672, 1829, 4724, 1829, 4587, 1829, 9381, 2423, 39184, 286, 539, 268, 1229, 1398, 383, 42, 17, 34051, 2423, 32277, 2304, 6024, 95, 34740, 46740, 383, 42, 47554], "avg_logprob": -0.29370777349214294, "compression_ratio": 1.0833333333333333, "no_speech_prob": 0.0, "words": [{"start": 897.68, "end": 898.0, "word": "هذه", "probability": 0.88232421875}, {"start": 898.0, "end": 898.64, "word": " فكرة", "probability": 0.9493815104166666}, {"start": 898.64, "end": 899.74, "word": " الـ", "probability": 0.717041015625}, {"start": 899.74, "end": 900.1, "word": " Kit", "probability": 0.167724609375}, {"start": 900.1, "end": 900.54, "word": " اللي", "probability": 0.833251953125}, {"start": 900.54, "end": 901.2, "word": " بيقيص", "probability": 0.77294921875}, {"start": 901.2, "end": 901.82, "word": " الـ", "probability": 0.807861328125}, {"start": 901.82, "end": 902.66, "word": " Isoenzyme", "probability": 0.85419921875}, {"start": 902.66, "end": 903.84, "word": " CK2", "probability": 0.7413736979166666}, {"start": 903.84, "end": 904.32, "word": " أو", "probability": 0.8720703125}, {"start": 904.32, "end": 904.72, "word": " الاسم", "probability": 0.7908528645833334}, {"start": 904.72, "end": 905.12, "word": " الآخر", "probability": 0.9539388020833334}, {"start": 905.12, "end": 905.34, "word": " له", "probability": 0.4970703125}, {"start": 905.34, "end": 906.7, "word": " CKMB", "probability": 0.56298828125}], "temperature": 1.0}, {"id": 41, "seek": 93789, "start": 908.95, "end": 937.89, "text": "CKNB procedure للأسف هذا الـ kit يعني هو كان موجود ولكن خلصناه فطريقة شغله سهلة كتير بنحضر working reagent فهمنا صارنا نعرف شو يعني working reagent يعني mix من two reagent يعني reagent A و B بخلطهم بكميات بتكون موجودة في ال pamphlet بحددها و بحضره بحطه في ال water bath جبل ما استخدمه تمام ع 37 بروح أجيب", "tokens": [34, 34559, 33, 10747, 24976, 10721, 3794, 5172, 23758, 2423, 39184, 8260, 37495, 22653, 31439, 25961, 3714, 29245, 23328, 35525, 19452, 16490, 1211, 9381, 8315, 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"word": " أو", "probability": 0.90869140625}, {"start": 1093.47, "end": 1093.65, "word": " ال", "probability": 0.4580078125}, {"start": 1093.65, "end": 1094.15, "word": " «CK", "probability": 0.935302734375}, {"start": 1094.15, "end": 1095.47, "word": " اتنان»", "probability": 0.709033203125}, {"start": 1095.47, "end": 1095.85, "word": " بس", "probability": 0.912841796875}, {"start": 1095.85, "end": 1096.33, "word": " احنا", "probability": 0.8834635416666666}], "temperature": 1.0}, {"id": 49, "seek": 110657, "start": 1097.35, "end": 1106.57, "text": "بدناش نطبق المعادلة اللي إحنا شايفينها هذه معادلة شوية معقدة و بدها حسابات، تمام؟", "tokens": [44510, 8315, 8592, 8717, 9566, 3555, 4587, 9673, 3615, 18513, 37977, 13672, 1829, 11933, 5016, 8315, 13412, 995, 33911, 9957, 11296, 29538, 20449, 18513, 37977, 13412, 2407, 10632, 20449, 28543, 3660, 4032, 47525, 11296, 11331, 3794, 16758, 9307, 12399, 46811, 10943, 22807], "avg_logprob": -0.19622092399486277, "compression_ratio": 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54, "seek": 121259, "start": 1203.4, "end": 1212.6, "text": "فاللي هنعتمده بطرح الـ two absorbance من بعض بضربهم بالـ factor بتطلع ليه النتيجة بالـ international unit per liter", "tokens": [5172, 6027, 20292, 8032, 1863, 34268, 2304, 3215, 3224, 4724, 9566, 2288, 5016, 2423, 39184, 732, 15631, 719, 9154, 45030, 11242, 4724, 11242, 25513, 16095, 20666, 39184, 5952, 39894, 9566, 1211, 3615, 32239, 3224, 28239, 31371, 7435, 3660, 20666, 39184, 5058, 4985, 680, 2733], "avg_logprob": -0.26059027512868244, "compression_ratio": 1.2352941176470589, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1203.4, "end": 1203.8, "word": "فاللي", "probability": 0.70458984375}, {"start": 1203.8, "end": 1204.5, "word": " هنعتمده", "probability": 0.8678385416666666}, {"start": 1204.5, "end": 1204.9, "word": " بطرح", "probability": 0.8336181640625}, {"start": 1204.9, "end": 1205.12, "word": " الـ", "probability": 0.66650390625}, {"start": 1205.12, "end": 1205.18, "word": " two", "probability": 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"word": " جوا،", "probability": 0.7420247395833334}, {"start": 1724.01, "end": 1724.75, "word": " تمام؟", "probability": 0.9749348958333334}], "temperature": 1.0}, {"id": 80, "seek": 175093, "start": 1725.09, "end": 1750.93, "text": "هذه البروتينات ترتبط بالخيوط المكوّنة للعضلات الهيكلية وعضلة القلب Troponin T-Troponin I-Troponin C هي التلت أنواع الوظيفة الأساسية لهذه البروتينات الموجودة في العضلات إنه داخل العضلة", "tokens": [3224, 24192, 2423, 26890, 35473, 9957, 9307, 6055, 43500, 3555, 9566, 20666, 9778, 1829, 2407, 9566, 9673, 4117, 2407, 11703, 1863, 3660, 24976, 3615, 11242, 1211, 9307, 2423, 3224, 1829, 28820, 10632, 4032, 3615, 11242, 37977, 25062, 46152, 43917, 266, 259, 314, 12, 51, 1513, 266, 259, 286, 12, 51, 1513, 266, 259, 383, 39896, 16712, 1211, 2655, 14739, 14407, 3615, 2423, 2407, 19913, 33911, 3660, 16247, 3794, 32277, 10632, 46740, 24192, 2423, 26890, 35473, 9957, 9307, 9673, 29245, 23328, 3660, 8978, 18863, 11242, 1211, 9307, 36145, 3224, 11778, 47283, 1211, 18863, 11242, 37977], "avg_logprob": -0.13906249309840954, "compression_ratio": 1.782857142857143, "no_speech_prob": 1.7285346984863281e-06, "words": [{"start": 1725.09, "end": 1725.45, "word": "هذه", "probability": 0.935546875}, {"start": 1725.45, "end": 1726.11, "word": " البروتينات", "probability": 0.90595703125}, {"start": 1726.11, "end": 1727.21, "word": " ترتبط", "probability": 0.9844970703125}, {"start": 1727.21, "end": 1728.55, "word": " بالخيوط", "probability": 0.9490234375}, {"start": 1728.55, "end": 1729.97, "word": " المكوّنة", "probability": 0.8535970052083334}, {"start": 1729.97, "end": 1731.25, "word": " للعضلات", "probability": 0.888671875}, {"start": 1731.25, "end": 1731.89, "word": " الهيكلية", "probability": 0.954296875}, {"start": 1731.89, "end": 1732.35, "word": " وعضلة", "probability": 0.909912109375}, {"start": 1732.35, "end": 1732.81, "word": " القلب", "probability": 0.995849609375}, {"start": 1732.81, "end": 1733.73, "word": " Troponin", "probability": 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"probability": 0.96318359375}, {"start": 1747.99, "end": 1748.61, "word": " الموجودة", "probability": 0.9398193359375}, {"start": 1748.61, "end": 1748.71, "word": " في", "probability": 0.95947265625}, {"start": 1748.71, "end": 1749.31, "word": " العضلات", "probability": 0.99609375}, {"start": 1749.31, "end": 1750.03, "word": " إنه", "probability": 0.4654541015625}, {"start": 1750.03, "end": 1750.39, "word": " داخل", "probability": 0.9720052083333334}, {"start": 1750.39, "end": 1750.93, "word": " العضلة", "probability": 0.9915364583333334}], "temperature": 1.0}, {"id": 81, "seek": 175873, "start": 1751.69, "end": 1758.73, "text": "هذه البروتينات ترتبط بالكالسوم وبتنظم عملية الإنقباض للعضلات", "tokens": [3224, 24192, 2423, 26890, 35473, 9957, 9307, 6055, 43500, 3555, 9566, 20666, 4117, 6027, 3794, 20498, 46599, 2655, 1863, 19913, 2304, 6225, 42213, 10632, 33688, 1863, 4587, 3555, 46958, 24976, 3615, 11242, 1211, 9307], "avg_logprob": -0.1940848273890359, "compression_ratio": 1.2696629213483146, "no_speech_prob": 0.0, "words": [{"start": 1751.69, "end": 1752.19, "word": "هذه", "probability": 0.95751953125}, {"start": 1752.19, "end": 1752.91, "word": " البروتينات", "probability": 0.893359375}, {"start": 1752.91, "end": 1753.71, "word": " ترتبط", "probability": 0.879150390625}, {"start": 1753.71, "end": 1754.49, "word": " بالكالسوم", "probability": 0.796533203125}, {"start": 1754.49, "end": 1755.65, "word": " وبتنظم", "probability": 0.768896484375}, {"start": 1755.65, "end": 1756.59, "word": " عملية", "probability": 0.9715169270833334}, {"start": 1756.59, "end": 1757.75, "word": " الإنقباض", "probability": 0.840380859375}, {"start": 1757.75, "end": 1758.73, "word": " للعضلات", "probability": 0.9451171875}], "temperature": 1.0}, {"id": 82, "seek": 179050, "start": 1764.8, "end": 1790.5, "text": "Tissue Specificity of Troponin SubunitsTroponin-C is the same in all muscle tissue بيحكيلي إن النوع الأول من البروتينات Troponin-C هذا النوع موجود في كل العضلات موجود في العضلات الهيكلية وموجود أيضا في عضلة القلب إذا Troponin-C هذا البروتين مش متخصص لعضلة القلب تمام؟", "tokens": [51, 891, 622, 20484, 1089, 507, 295, 43917, 266, 259, 8511, 409, 1208, 51, 1513, 266, 259, 12, 34, 307, 264, 912, 294, 439, 8679, 12404, 4724, 1829, 5016, 4117, 1829, 20292, 36145, 28239, 45367, 16247, 12610, 9154, 2423, 26890, 35473, 9957, 9307, 43917, 266, 259, 12, 34, 23758, 28239, 45367, 3714, 29245, 23328, 8978, 28242, 18863, 11242, 1211, 9307, 3714, 29245, 23328, 8978, 18863, 11242, 1211, 9307, 2423, 3224, 1829, 28820, 10632, 4032, 2304, 29245, 23328, 36632, 11242, 995, 8978, 6225, 11242, 37977, 25062, 46152, 11933, 15730, 43917, 266, 259, 12, 34, 23758, 2423, 26890, 35473, 9957, 37893, 44650, 9778, 9381, 9381, 5296, 3615, 11242, 37977, 25062, 46152, 46811, 10943, 22807], "avg_logprob": -0.12852600190491803, "compression_ratio": 1.7434782608695651, "no_speech_prob": 4.172325134277344e-07, "words": [{"start": 1764.8, "end": 1765.14, "word": "Tissue", "probability": 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"probability": 0.8828125}, {"start": 1772.56, "end": 1773.24, "word": " بيحكيلي", "probability": 0.85302734375}, {"start": 1773.24, "end": 1773.42, "word": " إن", "probability": 0.548828125}, {"start": 1773.42, "end": 1773.72, "word": " النوع", "probability": 0.923583984375}, {"start": 1773.72, "end": 1774.26, "word": " الأول", "probability": 0.992919921875}, {"start": 1774.26, "end": 1774.6, "word": " من", "probability": 0.9921875}, {"start": 1774.6, "end": 1775.36, "word": " البروتينات", "probability": 0.92763671875}, {"start": 1775.36, "end": 1776.2, "word": " Troponin", "probability": 0.8302408854166666}, {"start": 1776.2, "end": 1776.62, "word": "-C", "probability": 0.963623046875}, {"start": 1776.62, "end": 1777.2, "word": " هذا", "probability": 0.74853515625}, {"start": 1777.2, "end": 1777.5, "word": " النوع", "probability": 0.992431640625}, {"start": 1777.5, "end": 1778.02, "word": " موجود", "probability": 0.9845377604166666}, {"start": 1778.02, "end": 1778.18, "word": " في", "probability": 0.97900390625}, {"start": 1778.18, "end": 1778.52, "word": " كل", "probability": 0.9912109375}, {"start": 1778.52, "end": 1779.3, "word": " العضلات", "probability": 0.97900390625}, {"start": 1779.3, "end": 1779.92, "word": " موجود", "probability": 0.9287109375}, {"start": 1779.92, "end": 1780.06, "word": " في", "probability": 0.978515625}, {"start": 1780.06, "end": 1780.54, "word": " العضلات", "probability": 0.99609375}, {"start": 1780.54, "end": 1781.22, "word": " الهيكلية", "probability": 0.96484375}, {"start": 1781.22, "end": 1781.88, "word": " وموجود", "probability": 0.9114990234375}, {"start": 1781.88, "end": 1782.32, "word": " أيضا", "probability": 0.8811848958333334}, {"start": 1782.32, "end": 1782.5, "word": " في", "probability": 0.951171875}, {"start": 1782.5, "end": 1782.9, "word": " عضلة", "probability": 0.9900716145833334}, {"start": 1782.9, "end": 1783.58, "word": " القلب", "probability": 0.9970703125}, {"start": 1783.58, "end": 1784.18, "word": " إذا", "probability": 0.530029296875}, {"start": 1784.18, "end": 1785.02, "word": " Troponin", "probability": 0.8263346354166666}, {"start": 1785.02, "end": 1785.4, "word": "-C", "probability": 0.98583984375}, {"start": 1785.4, "end": 1785.96, "word": " هذا", "probability": 0.81884765625}, {"start": 1785.96, "end": 1786.62, "word": " البروتين", "probability": 0.9832763671875}, {"start": 1786.62, "end": 1787.18, "word": " مش", "probability": 0.9189453125}, {"start": 1787.18, "end": 1788.12, "word": " متخصص", "probability": 0.9927978515625}, {"start": 1788.12, "end": 1788.82, "word": " لعضلة", "probability": 0.9365234375}, {"start": 1788.82, "end": 1789.46, "word": " القلب", "probability": 0.9970703125}, {"start": 1789.46, "end": 1790.5, "word": " تمام؟", "probability": 0.86962890625}], "temperature": 1.0}, {"id": 83, "seek": 182030, "start": 1790.84, "end": 1820.3, "text": "التروبونين I and T have cardiac specific forms هذا اختصار لcardiac-troponin I and cardiac-troponin T بيحكي للنوعين التانين، تروبونين I وT هدولة بشكل أساسي موجودين في الcardiac موجودين بشكل أساسي بعضلة القلب ومش موجودين بالعضلات الأخرى بس تروبونين C موجود بكل العضلات", "tokens": [6027, 2655, 32887, 3555, 11536, 9957, 286, 293, 314, 362, 32129, 2685, 6422, 23758, 1975, 46456, 9381, 9640, 5296, 22259, 13921, 12, 83, 1513, 266, 259, 286, 293, 32129, 12, 83, 1513, 266, 259, 314, 4724, 1829, 5016, 4117, 1829, 24976, 1863, 45367, 9957, 16712, 7649, 9957, 12399, 6055, 32887, 3555, 11536, 9957, 286, 4032, 51, 8032, 3215, 12610, 3660, 4724, 8592, 28820, 5551, 3794, 32277, 1829, 3714, 29245, 23328, 9957, 8978, 2423, 22259, 13921, 3714, 29245, 23328, 9957, 4724, 8592, 28820, 5551, 3794, 32277, 1829, 45030, 11242, 37977, 25062, 46152, 4032, 2304, 8592, 3714, 29245, 23328, 9957, 20666, 3615, 11242, 1211, 9307, 16247, 34740, 7578, 4724, 3794, 6055, 32887, 3555, 11536, 9957, 383, 3714, 29245, 23328, 4724, 28820, 18863, 11242, 1211, 9307], "avg_logprob": -0.16129031657211243, "compression_ratio": 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{"start": 1799.16, "end": 1800.04, "word": "-troponin", "probability": 0.81982421875}, {"start": 1800.04, "end": 1800.54, "word": " I", "probability": 0.8720703125}, {"start": 1800.54, "end": 1801.04, "word": " and", "probability": 0.76318359375}, {"start": 1801.04, "end": 1801.66, "word": " cardiac", "probability": 0.451904296875}, {"start": 1801.66, "end": 1802.56, "word": "-troponin", "probability": 0.93525390625}, {"start": 1802.56, "end": 1802.82, "word": " T", "probability": 0.99169921875}, {"start": 1802.82, "end": 1803.52, "word": " بيحكي", "probability": 0.89033203125}, {"start": 1803.52, "end": 1804.18, "word": " للنوعين", "probability": 0.979248046875}, {"start": 1804.18, "end": 1805.14, "word": " التانين،", "probability": 0.79052734375}, {"start": 1805.14, "end": 1805.74, "word": " تروبونين", "probability": 0.8421875}, {"start": 1805.74, "end": 1806.14, "word": " I", "probability": 0.9970703125}, {"start": 1806.14, "end": 1806.58, "word": " وT", "probability": 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ومش", "probability": 0.9651692708333334}, {"start": 1814.14, "end": 1814.9, "word": " موجودين", "probability": 0.989501953125}, {"start": 1814.9, "end": 1815.96, "word": " بالعضلات", "probability": 0.9658203125}, {"start": 1815.96, "end": 1816.88, "word": " الأخرى", "probability": 0.9864908854166666}, {"start": 1816.88, "end": 1817.38, "word": " بس", "probability": 0.95654296875}, {"start": 1817.38, "end": 1818.02, "word": " تروبونين", "probability": 0.898828125}, {"start": 1818.02, "end": 1818.28, "word": " C", "probability": 0.95458984375}, {"start": 1818.28, "end": 1819.02, "word": " موجود", "probability": 0.9856770833333334}, {"start": 1819.02, "end": 1819.56, "word": " بكل", "probability": 0.6890869140625}, {"start": 1819.56, "end": 1820.3, "word": " العضلات", "probability": 0.99755859375}], "temperature": 1.0}, {"id": 84, "seek": 184488, "start": 1820.54, "end": 1844.88, "text": "تمام؟ Circulating concentration of Troponin I and Troponin T are very low يعني الوضع الـ Normal إن Troponin I وT موجودين في الـ blood at very low concentration حتى فيه بيحكوا إن أفضل لتروبنين كلها تركي .. يعني", "tokens": [39237, 10943, 22807, 13791, 2444, 990, 9856, 295, 43917, 266, 259, 286, 293, 43917, 266, 259, 314, 366, 588, 2295, 37495, 22653, 2423, 2407, 11242, 3615, 2423, 39184, 21277, 36145, 43917, 266, 259, 286, 4032, 51, 3714, 29245, 23328, 9957, 8978, 2423, 39184, 3390, 412, 588, 2295, 9856, 11331, 49975, 8978, 3224, 4724, 1829, 5016, 4117, 14407, 36145, 5551, 5172, 11242, 1211, 5296, 2655, 32887, 3555, 1863, 9957, 28242, 11296, 6055, 31747, 1829, 4386, 37495, 22653], "avg_logprob": -0.3001217408613725, "compression_ratio": 1.4307692307692308, "no_speech_prob": 1.3113021850585938e-06, "words": [{"start": 1820.54, "end": 1821.6, "word": "تمام؟", "probability": 0.6439615885416666}, {"start": 1821.6, "end": 1823.28, "word": " Circulating", "probability": 0.68377685546875}, {"start": 1823.28, "end": 1824.32, "word": " concentration", "probability": 0.76220703125}, {"start": 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"برجع لوضعه الطبيعي و لتركيزه الطبيعي Troponin-T tend to remain elevated longer يعني حكينا في ال slide اللي قبل أن Troponin-T بيضلوا سبع أيام يعني أطول مدة من Troponin-I بيضلوا عالي في الدم", "tokens": [26890, 7435, 3615, 5296, 2407, 11242, 3615, 3224, 41950, 21292, 3615, 1829, 4032, 5296, 2655, 31747, 1829, 11622, 3224, 41950, 21292, 3615, 1829, 43917, 266, 259, 12, 51, 3928, 281, 6222, 23457, 2854, 37495, 22653, 11331, 4117, 1829, 8315, 8978, 2423, 4137, 13672, 1829, 12174, 36150, 14739, 43917, 266, 259, 12, 51, 4724, 1829, 11242, 1211, 14407, 8608, 3555, 3615, 36632, 10943, 37495, 22653, 5551, 9566, 12610, 3714, 41891, 9154, 43917, 266, 259, 12, 40, 4724, 1829, 11242, 1211, 14407, 6225, 6027, 1829, 8978, 32748, 2304], "avg_logprob": -0.16154812636046573, "compression_ratio": 1.5722222222222222, "no_speech_prob": 1.2516975402832031e-06, "words": [{"start": 2219.6, "end": 2220.36, "word": "برجع", "probability": 0.8375651041666666}, {"start": 2220.36, "end": 2221.88, "word": " لوضعه", 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infarct than Troponin I بيحكيلي إن Troponin T فيه إلو مستان أول إشي إنه بيضلوا تركيزه عالي في الدم لفترة أكتر من Troponin I وأيضا sensitive أكتر يعني أول ما يصير ال heart damage بيبدأ هو يطلع ويزيد تركيزه جبل لTroponin I", "tokens": [474, 6909, 2946, 19392, 934, 786, 1614, 934, 1536, 289, 349, 813, 43917, 266, 259, 286, 4724, 1829, 5016, 4117, 1829, 20292, 36145, 43917, 266, 259, 314, 8978, 3224, 11933, 1211, 2407, 3714, 14851, 7649, 5551, 12610, 11933, 8592, 1829, 36145, 3224, 4724, 1829, 11242, 1211, 14407, 6055, 31747, 1829, 11622, 3224, 6225, 6027, 1829, 8978, 32748, 2304, 5296, 5172, 2655, 25720, 5551, 4117, 2655, 2288, 9154, 43917, 266, 259, 286, 36725, 1829, 11242, 995, 9477, 5551, 4117, 2655, 2288, 37495, 22653, 5551, 12610, 19446, 7251, 9381, 13546, 2423, 1917, 4344, 4724, 1829, 44510, 10721, 31439, 7251, 9566, 1211, 3615, 4032, 1829, 11622, 25708, 6055, 31747, 1829, 11622, 3224, 10874, 36150, 5296, 51, 1513, 266, 259, 286], "avg_logprob": -0.15320445571915578, 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حتى لو ارتفعت بتركيز قليل بتتم الكشف عنه High sensitivity CRP", "tokens": [3224, 15730, 44650, 9778, 9381, 9381, 8978, 33251, 8592, 5172, 18871, 5551, 4587, 1211, 9122, 2304, 10632, 9154, 2423, 39184, 14123, 47, 3714, 29245, 23328, 3660, 8978, 32748, 2304, 37495, 22653, 5551, 12610, 19446, 2423, 39184, 14123, 47, 7251, 44510, 10721, 7251, 43500, 5172, 3615, 11331, 49975, 45164, 1975, 43500, 5172, 34268, 39894, 31747, 1829, 11622, 12174, 20292, 1211, 39894, 39237, 33251, 8592, 5172, 18871, 3224, 5229, 19392, 14123, 47], "avg_logprob": -0.11608714578856885, "compression_ratio": 1.4523809523809523, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 2344.31, "end": 2345.27, "word": "هذا", "probability": 0.912841796875}, {"start": 2345.27, "end": 2346.43, "word": " متخصص", "probability": 0.960205078125}, {"start": 2346.43, "end": 2346.61, "word": " في", "probability": 0.8681640625}, {"start": 2346.61, "end": 2347.17, "word": " الكشف", "probability": 0.9664713541666666}, {"start": 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{"start": 2392.08, "end": 2393.34, "word": " أيضا", "probability": 0.79443359375}, {"start": 2393.34, "end": 2393.98, "word": " بيرتفع", "probability": 0.9408203125}, {"start": 2393.98, "end": 2394.14, "word": " في", "probability": 0.9755859375}, {"start": 2394.14, "end": 2394.54, "word": " حالات", "probability": 0.9736328125}, {"start": 2394.54, "end": 2394.68, "word": " ال", "probability": 0.9443359375}, {"start": 2394.68, "end": 2395.1, "word": " injury", "probability": 0.958984375}, {"start": 2395.1, "end": 2396.26, "word": " الإصابات", "probability": 0.9229736328125}, {"start": 2396.26, "end": 2396.86, "word": " في", "probability": 0.7275390625}, {"start": 2396.86, "end": 2397.24, "word": " حالات", "probability": 0.9635416666666666}, {"start": 2397.24, "end": 2397.38, "word": " ال", "probability": 0.94091796875}, {"start": 2397.38, "end": 2397.86, "word": " infection", "probability": 0.8369140625}], "temperature": 1.0}, {"id": 110, "seek": 241567, "start": 2398.66, "end": 2415.68, "text": "في حالات الـinflammatory condition كلها بنركز في حالات ال injury يعني لو حدث عندي damage في عضو معين أو injury في عضو معين it is non specific كلنا عارفين مش متخصص فقط بعطيكي مؤشر أنه في إلتهاب وين الإلتهاب ما بيحدد المكان", "tokens": [41185, 11331, 6027, 9307, 2423, 39184, 45684, 4745, 4188, 28242, 11296, 44945, 31747, 11622, 8978, 11331, 6027, 9307, 2423, 10454, 37495, 22653, 45164, 11331, 3215, 12984, 18871, 16254, 4344, 8978, 6225, 11242, 2407, 20449, 9957, 34051, 10454, 8978, 6225, 11242, 2407, 20449, 9957, 309, 307, 2107, 2685, 28242, 8315, 6225, 9640, 5172, 9957, 37893, 44650, 9778, 9381, 9381, 6156, 47432, 4724, 3615, 9566, 1829, 4117, 1829, 3714, 33604, 46309, 14739, 3224, 8978, 11933, 1211, 2655, 11296, 3555, 4032, 9957, 33688, 1211, 2655, 11296, 3555, 19446, 4724, 1829, 24401, 3215, 9673, 41361], "avg_logprob": -0.1598165730095428, "compression_ratio": 1.599078341013825, "no_speech_prob": 8.940696716308594e-07, "words": [{"start": 2398.66, "end": 2398.88, "word": 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2408.38, "word": " is", "probability": 0.876953125}, {"start": 2408.38, "end": 2408.52, "word": " non", "probability": 0.6328125}, {"start": 2408.52, "end": 2409.06, "word": " specific", "probability": 0.67138671875}, {"start": 2409.06, "end": 2409.44, "word": " كلنا", "probability": 0.788330078125}, {"start": 2409.44, "end": 2409.7, "word": " عارفين", "probability": 0.991943359375}, {"start": 2409.7, "end": 2409.92, "word": " مش", "probability": 0.9765625}, {"start": 2409.92, "end": 2410.68, "word": " متخصص", "probability": 0.9945068359375}, {"start": 2410.68, "end": 2411.2, "word": " فقط", "probability": 0.99169921875}, {"start": 2411.2, "end": 2411.92, "word": " بعطيكي", "probability": 0.8128255208333334}, {"start": 2411.92, "end": 2412.4, "word": " مؤشر", "probability": 0.9850260416666666}, {"start": 2412.4, "end": 2412.78, "word": " أنه", "probability": 0.6422119140625}, {"start": 2412.78, "end": 2412.9, "word": " في", "probability": 0.9580078125}, {"start": 2412.9, "end": 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36145, 3224, 34105, 4117, 16712, 3224, 16758, 9307, 6225, 42213, 2655, 37893, 995, 28820, 8978, 25062, 46152, 16070, 10721, 45367, 10632, 32748, 2304, 2407, 10632, 46599, 3224, 4117, 44945, 39648, 36145, 13412, 16606, 21984, 16490, 1211, 9381, 8315, 13412, 3555, 2655, 2288, 8315, 4032, 40228, 9566, 1829, 4117, 14407, 18863, 31845, 10632], "avg_logprob": -0.17261029832503375, "compression_ratio": 1.4439655172413792, "no_speech_prob": 1.0132789611816406e-06, "words": [{"start": 2415.97, "end": 2416.89, "word": "CRP", "probability": 0.574951171875}, {"start": 2416.89, "end": 2417.11, "word": " may", "probability": 0.257080078125}, {"start": 2417.11, "end": 2417.37, "word": " be", "probability": 0.95556640625}, {"start": 2417.37, "end": 2418.17, "word": " considered", "probability": 0.80859375}, {"start": 2418.17, "end": 2418.71, "word": " as", "probability": 0.9619140625}, {"start": 2418.71, "end": 2418.97, "word": " a", "probability": 0.91796875}, {"start": 2418.97, "end": 2419.27, "word": " risk", "probability": 0.9501953125}, {"start": 2419.27, "end": 2419.85, "word": " factor", "probability": 0.76953125}, {"start": 2419.85, "end": 2420.65, "word": " marker", "probability": 0.736328125}, {"start": 2420.65, "end": 2420.97, "word": " for", "probability": 0.89208984375}, {"start": 2420.97, "end": 2421.71, "word": " cardiovascular", "probability": 0.8369140625}, {"start": 2421.71, "end": 2422.57, "word": " disease", "probability": 0.91064453125}, {"start": 2422.57, "end": 2423.27, "word": " لما", "probability": 0.888427734375}, {"start": 2423.27, "end": 2423.49, "word": " الـ", "probability": 0.721923828125}, {"start": 2423.49, "end": 2424.01, "word": " CRP", "probability": 0.902099609375}, {"start": 2424.01, "end": 2424.67, "word": " يرتفع", "probability": 0.9840087890625}, {"start": 2424.67, "end": 2425.47, "word": " ممكن", "probability": 0.84912109375}, {"start": 2425.47, "end": 2426.19, "word": " يكون", "probability": 0.9931640625}, {"start": 2426.19, "end": 2426.83, "word": " عندي", "probability": 0.692138671875}, {"start": 2426.83, "end": 2427.91, "word": " مؤشر", "probability": 0.9825846354166666}, {"start": 2427.91, "end": 2428.65, "word": " إنه", "probability": 0.6973876953125}, {"start": 2428.65, "end": 2429.55, "word": " هناك", "probability": 0.972900390625}, {"start": 2429.55, "end": 2430.51, "word": " التهابات", "probability": 0.8343505859375}, {"start": 2430.51, "end": 2431.27, "word": " عملت", "probability": 0.9720052083333334}, {"start": 2431.27, "end": 2431.83, "word": " مشاكل", "probability": 0.9943033854166666}, {"start": 2431.83, "end": 2432.03, "word": " في", "probability": 0.9873046875}, {"start": 2432.03, "end": 2432.51, "word": " القلب", "probability": 0.9912109375}, {"start": 2432.51, "end": 2433.11, "word": " والأوعية", "probability": 0.7611083984375}, {"start": 2433.11, "end": 2434.07, "word": " الدموية", "probability": 0.9693603515625}, {"start": 2434.07, "end": 2436.03, "word": " وبهك", "probability": 0.7071940104166666}, {"start": 2436.03, "end": 2436.39, "word": " بنقول", "probability": 0.927001953125}, {"start": 2436.39, "end": 2436.53, "word": " إن", "probability": 0.7353515625}, {"start": 2436.53, "end": 2436.69, "word": " شاء", "probability": 0.914794921875}, {"start": 2436.69, "end": 2436.81, "word": " الله", "probability": 0.96533203125}, {"start": 2436.81, "end": 2437.31, "word": " خلصنا", "probability": 0.984130859375}, {"start": 2437.31, "end": 2437.93, "word": " شبترنا", "probability": 0.8177734375}, {"start": 2437.93, "end": 2438.47, "word": " ويعطيكوا", "probability": 0.7554931640625}, {"start": 2438.47, "end": 2438.89, "word": " العافية", "probability": 0.9484049479166666}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2439.7903125, "duration_after_vad": 2399.3562499999966}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/OEKZUS3N-iI.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/OEKZUS3N-iI.srt
new file mode 100644
index 0000000000000000000000000000000000000000..6bd5c602f87c43776351c872c9c280c8c8b6c85e
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/OEKZUS3N-iI.srt
@@ -0,0 +1,1636 @@
+1
+00:00:00,770 --> 00:00:04,750
+هنحكي هنا عن الفحص الثاني اللي بيشيك على الـ
+
+2
+00:00:04,750 --> 00:00:08,670
+Hepatocellular injury هل خلايا الكبد فيها damage
+
+3
+00:00:08,670 --> 00:00:13,530
+ولا لأ، الإنزيم الآخر، الـ ALT (Alanine
+
+4
+00:00:13,530 --> 00:00:18,270
+Aminotransferase)، إنزيم  له نشاط إنزيمي
+
+5
+00:00:18,270 --> 00:00:23,410
+مشابه لـ AST، شغله يا جماعة نفس شغل الـ
+
+6
+00:00:23,410 --> 00:00:29,650
+AST، إيه شغلهم؟ ينقل أمين جروب (مجموعة أمين) من مكان
+
+7
+00:00:29,650 --> 00:00:37,360
+لمكان آخر، تمام؟  هذا الـ ALT (Converts) يحول الألانين
+
+8
+00:00:37,360 --> 00:00:42,440
+والألفا كيتو جلو تاريت إلى مادة البيروفات
+
+9
+00:00:42,440 --> 00:00:46,840
+والجلوتامات، زي ما أنتم شايفين، هي الـ Amino Acid
+
+10
+00:00:46,840 --> 00:00:52,380
+الحمض الأميني، الألانين مع ألفا كيتو جلو تاريت في
+
+11
+00:00:52,380 --> 00:00:57,100
+وجود الـ ALT إنزيم، إيش بيعمل؟ بنزع الـ Amino
+
+12
+00:00:57,100 --> 00:01:01,630
+Group الموجودة في الحمض الأميني الألانين وبياخدها
+
+13
+00:01:01,630 --> 00:01:06,690
+وبينقلها على المركب الآخر، الـ α- كيتو جلو تاريت
+
+14
+00:01:06,690 --> 00:01:13,410
+محصلة النقل أن الألانين هيتحول لـ Pyruvate والـ
+
+15
+00:01:13,410 --> 00:01:18,670
+α-كيتو جلو تاريت هذه المادة هتتحول لـ Glutamate
+
+16
+00:01:18,670 --> 00:01:25,130
+طبعًا مش هطلب منكم المعادلة وفي التحويل، بس للعلم ول
+
+17
+00:01:25,130 --> 00:01:31,030
+للفهم، الـ Clinical Significance للفحص، الأهمية
+
+18
+00:01:31,030 --> 00:01:35,590
+التشخيصية لفحص الـ ALT، it is found in the kidneys,
+
+19
+00:01:35,910 --> 00:01:39,910
+heart and skeletal muscle tissue, but primarily in
+
+20
+00:01:39,910 --> 00:01:44,030
+the liver tissue، بيحكي لي إنزيم الـ ALT، وين
+
+21
+00:01:44,030 --> 00:01:47,910
+الأماكن اللي بيكون موجود فيها بشكل أساسي، موجود في
+
+22
+00:01:47,910 --> 00:01:53,470
+الكبد، والقلب، والعضلات الهيكلية، و RBCs، أضيف كمان
+
+23
+00:01:53,620 --> 00:01:57,400
+الـ Red Blood Cells (خلايا الدم الحمراء)، موجود في هذه
+
+24
+00:01:57,400 --> 00:02:02,760
+الأماكن يا جماعة، بتركيز قليل جدًا، لا يُذكر، تمام؟
+
+25
+00:02:02,760 --> 00:02:07,680
+لكنه موجود بـ primarily، ولكن بشكل أساسي، الـ ALT
+
+26
+00:02:07,680 --> 00:02:12,600
+موجود في خلايا الكبد، إذا الـ ALT موجود في الـ
+
+27
+00:02:12,600 --> 00:02:16,280
+kidney، والـ heart، والـ skeletal muscle، والـ RBCs
+
+28
+00:02:16,840 --> 00:02:22,080
+بكميات قليلة جدًا، لكن في ال liver tissue موجود بـ
+
+29
+00:02:22,080 --> 00:02:28,040
+high concentration (بتركيز عالي)، تمام، في الدم، في الـ
+
+30
+00:02:28,040 --> 00:02:34,220
+serum، زي زي الـ AST، الـ ALT موجود بتركيز قليل جدًا
+
+31
+00:02:34,220 --> 00:02:38,960
+في الإنسان الطبيعي، الـ ALT يكون موجود في الـ serum
+
+32
+00:02:38,960 --> 00:02:43,830
+ولكن بتركيز قليل، لكن وين موجود أكثر شيء في الـ
+
+33
+00:02:43,830 --> 00:02:48,910
+tissue، في الأنسجة، تمام؟ وبشكل أساسي في الكبد، الـ
+
+34
+00:02:48,910 --> 00:02:52,470
+test is used mainly in the diagnosis of liver
+
+35
+00:02:52,470 --> 00:02:55,990
+disease and to monitor the effects of hepatotoxic
+
+36
+00:02:55,990 --> 00:03:01,850
+drugs، الفحص بينعمل بشكل أساسي، فحص الـ ALT، عشان نشخص
+
+37
+00:03:01,850 --> 00:03:06,930
+مشاكل الكبد، وخاصة المشاكل اللي بتصيب الخلايا،
+
+38
+00:03:06,930 --> 00:03:13,700
+تمام؟ وأيضًا عشان نتابع تأثير الأدوية السامة على
+
+39
+00:03:13,700 --> 00:03:19,260
+الكبد، أحيانًا في الـ Drugs، ممكن بعض الأدوية تؤثر
+
+40
+00:03:19,260 --> 00:03:24,520
+على الكبد، تمام؟ وتؤثر على خلايا الكبد، وتعمل injury
+
+41
+00:03:24,520 --> 00:03:30,040
+فيها، فإحنا من خلال فحص الـ ALT بنتابع هذه الأدوية
+
+42
+00:03:30,040 --> 00:03:35,940
+تمام؟ often higher than AST with liver damage and
+
+43
+00:03:35,940 --> 00:03:42,780
+tend to remain elevated longer، هنا بيحكي لي الـ ALT
+
+44
+00:03:42,780 --> 00:03:48,220
+عادة تركيزه أعلى من الـ AST في حالات liver damage
+
+45
+00:03:48,220 --> 00:03:53,160
+يعني لو صار عندي مشكلة في الكبد (liver damage)، الـ
+
+46
+00:03:53,160 --> 00:03:57,720
+AST والـ ALT، الإثنين موجودين في الكبد، تمام؟ بس
+
+47
+00:03:57,720 --> 00:04:02,220
+مين موجود أكثر في الكبد؟ الـ ALT، الـ ALT موجود في
+
+48
+00:04:02,220 --> 00:04:06,700
+الكبد بتركيز عالي كثير، أعلى من الـ AST، فلما بيصير
+
+49
+00:04:06,700 --> 00:04:11,860
+عندي مشكلة في الكبد، هيطلع الـ ALT والـ AST للخارج،
+
+50
+00:04:11,860 --> 00:04:17,110
+على الدم، تمام؟ وبالتالي الـ ALT والـ AST الإثنين
+
+51
+00:04:17,110 --> 00:04:22,050
+هيزيدوا في الدم، بس الـ ALT هيزيد أكثر من الـ AST
+
+52
+00:04:22,050 --> 00:04:28,250
+لأنه أصلًا هو تركيزه في الـ liver أكثر وأعلى
+
+53
+00:04:28,250 --> 00:04:32,690
+وبالتالي لما يطلعوا الإثنين على الدم، الـ ALT والـ
+
+54
+00:04:32,690 --> 00:04:38,510
+AST بيزيدوا، بس الـ ALT بيكون أعلى من الـ AST، تمام؟
+
+55
+00:04:38,510 --> 00:04:44,250
+أيضًا كمان شغلة، إذًا كمان شغلة ثانية بدنا نعرفها أنه
+
+56
+00:04:44,250 --> 00:04:49,090
+غير أن الـ ALT بيكون أعلى من الـ AST في حالات
+
+57
+00:04:49,090 --> 00:04:54,390
+liver damage، كمان الـ ALT بيظل عالي في الدم
+
+58
+00:04:54,390 --> 00:05:02,690
+لفترة أطول من الـ AST، حكينا أنه يعني more liver
+
+59
+00:05:02,690 --> 00:05:07,930
+يعني كمان شغلة ثانية، more liver specific than AST
+
+60
+00:05:07,930 --> 00:05:13,510
+إذاً في ثلاث شغلات بدنا نأخذها بعين الاعتبار، الـ ALT
+
+61
+00:05:13,510 --> 00:05:18,050
+في الكبد تركيزه أعلى من الـ AST، فلما بيصير liver
+
+62
+00:05:18,050 --> 00:05:24,070
+damage، الإثنين بيطلعوا على الدم، لكن في الدم الـ ALT
+
+63
+00:05:24,070 --> 00:05:30,490
+هيكون تركيزه أعلى من الـ AST، ومش بس هيك، كمان الـ ALT
+
+64
+00:05:30,490 --> 00:05:37,150
+بيظل عالي لفترة طويلة، أطول من الـ AST، يعني ممكن
+
+65
+00:05:37,150 --> 00:05:43,270
+بعد خمس، ست أيام، الـ AST يرجع طبيعي، ويظل الـ ALT
+
+66
+00:05:43,270 --> 00:05:49,150
+عالي في الـ Serum، تمام، شغلة ثالثة بيحكي لنا أن الـ
+
+67
+00:05:49,150 --> 00:05:57,230
+ALT يعتبر متخصص أكثر من الـ AST، متخصص للكبد، فحص
+
+68
+00:05:57,230 --> 00:06:03,700
+الـ ALT متخصص أكثر في الكبد من فحص الـ AST، تفاجأنا أن
+
+69
+00:06:03,700 --> 00:06:09,280
+الـ AST مش متخصص، بيرتفع في حالات النوبة القلبية، بيرتفع
+
+70
+00:06:09,280 --> 00:06:14,860
+في حالات مشاكل الكبد، لكن الـ ALT بقول لك remains
+
+71
+00:06:14,860 --> 00:06:20,040
+normal in acute myocardial infarction (يبقى طبيعي
+
+72
+00:06:20,040 --> 00:06:25,400
+في حالات النوبة القلبية)، إذن هو متخصص أكثر شيء للكبد
+
+73
+00:06:25,960 --> 00:06:30,260
+ليش يا جماعة، مع أنه هتسألوني، هتحكوا لي طيب الـ ALT
+
+74
+00:06:30,260 --> 00:06:34,880
+هو موجود في القلب، حكيناه، وفي الـ kidney، طيب ليش
+
+75
+00:06:34,880 --> 00:06:39,140
+في حالات النوبة القلبية ما بيزيد؟ لأنه حكيت لكم هو
+
+76
+00:06:39,140 --> 00:06:42,200
+موجود في الـ kidney، والـ heart، والـ skeletal
+
+77
+00:06:42,200 --> 00:06:48,420
+muscle، والـ RBCs بكميات قليلة جدًا، مش زي الـ AST،
+
+78
+00:06:48,420 --> 00:06:52,760
+الـ AST موجود في هذه الأنسجة بكميات أكبر، وبالتالي
+
+79
+00:06:52,760 --> 00:06:56,680
+الـ ALT موجود في عضلة القلب، ولكن بكميات قليلة، يعني
+
+80
+00:06:56,680 --> 00:07:00,320
+لما بيصير دمج في القلب ويطلع الـ ALT على الـ
+
+81
+00:07:00,320 --> 00:07:05,220
+Serum، على الدم، مش كثير هيزيد تركيزه أو هيفرق
+
+82
+00:07:05,220 --> 00:07:09,020
+معاه، تمام؟ وبالتالي بيظل ضمن الـ Normal Range،
+
+83
+00:07:09,020 --> 00:07:15,020
+إذاً فحص الـ ALT متخصص أكثر من فحص الـ AST للكبد
+
+84
+00:07:17,040 --> 00:07:21,580
+الـ Specimen Collection (نوع العينة)، زي الـ AST، سيرم
+
+85
+00:07:21,580 --> 00:07:25,140
+أو بلازما، البلازما، نوع الـ Anticoagulant، EDTA أو
+
+86
+00:07:25,140 --> 00:07:30,820
+هيبارين، تمام؟ لأنه كمان الـ ALT موجود جوا الـ RBCs
+
+87
+00:07:30,820 --> 00:07:35,240
+يعني بدي أتجنب أجمع عينة Hemolyzed، والعينة الـ
+
+88
+00:07:35,240 --> 00:07:39,660
+Hemolyzed بدي أعملها rejection (أرفضها)، ليش؟ لأنه لو
+
+89
+00:07:39,660 --> 00:07:44,600
+العينة صار لها Hemolysis، هيطلع الـ ALT من الـ RBCs
+
+90
+00:07:44,600 --> 00:07:48,630
+على السيرم، يزيد تركيزه في الـ Serum بشكل خاطئ
+
+91
+00:07:48,630 --> 00:07:56,770
+معلومة أن الـ ALT موجود بالـ RBCs تقريبًا بـ 5
+
+92
+00:07:56,770 --> 00:08:01,010
+أضعاف الـ ALT اللي موجود في الـ Serum، يعني هو
+
+93
+00:08:01,010 --> 00:08:07,090
+موجود في الـ RBCs، ولكن بـ 5 أضعاف، تمام؟ لو بتتذكروا
+
+94
+00:08:07,090 --> 00:08:13,600
+الـ AST، موجود، الـ AST في الـ RBCs بـ 15 ضعف، يعني
+
+95
+00:08:13,600 --> 00:08:19,880
+الـ AST موجود في الـ RBCs بكميات أكبر من الـ ALT
+
+96
+00:08:19,880 --> 00:08:25,020
+تمام؟ هذه معلومة مهمة، الـ AST موجود في الـ RBCs
+
+97
+00:08:25,020 --> 00:08:31,740
+بكميات أكبر من الـ ALT، الـ "Say for enzyme
+
+98
+00:08:31,740 --> 00:08:36,140
+activity"، قياس الـ activity  تبع الإنزيم، الطرق
+
+99
+00:08:36,140 --> 00:08:41,460
+المستخدمة في قياس الـ activity تبع إنزيم الـ ALT
+
+100
+00:08:42,350 --> 00:08:48,250
+طبعًا الطريقة ومبدأ الشغل نفس مبدأ شغل الـ AST، مش
+
+101
+00:08:48,250 --> 00:08:52,030
+هي إنزيمات، كلها نفس المبدأ، الكلام المكتوب بالـ
+
+102
+00:08:52,030 --> 00:08:58,330
+slide، تلخيصه في المربع اللي تحت، الأبيض، هذا الـ
+
+103
+00:08:58,330 --> 00:09:02,430
+principle (مبدأ الفحص)، نفس الـ AST بالظبط يا جماعة
+
+104
+00:09:03,290 --> 00:09:07,070
+الـ Serum تبع المريض بيكون فيه الـ ALT، الـ
+
+105
+00:09:07,070 --> 00:09:10,490
+enzyme اللي أنا بدي أحسب الـ activity تبعته، بدي
+
+106
+00:09:10,490 --> 00:09:15,390
+أحسب نشاطه، لأنه نشاطه هيعبر عن الـ concentration
+
+107
+00:09:15,390 --> 00:09:25,350
+لهذا الـ enzyme، تمام؟ هلجيت؟ الألانين والألفا
+
+108
+00:09:25,350 --> 00:09:32,870
+كيتو جلو تاريت، هذه substrate موجودة في الـ reagent، هل
+
+109
+00:09:32,870 --> 00:09:35,990
+جات الألانين، حكيناه، والـ Alpha-ketoglutarate
+
+110
+00:09:35,990 --> 00:09:40,950
+substrate، هذه المواد موجودة في الـ Reagent، لما نخلط
+
+111
+00:09:40,950 --> 00:09:45,710
+الـ Reagent على عينة المريض، على السيرم، الـ ALT
+
+112
+00:09:45,710 --> 00:09:49,670
+الموجود في السيرم هيشتغل على الـ substrate اللي
+
+113
+00:09:49,670 --> 00:09:53,630
+موجودة في الـ Reagent، ويحول الألانين لـ Pyruvate
+
+114
+00:09:53,630 --> 00:09:57,930
+والـ Alpha-ketoglutarate لـ Glutamate، البيروفات
+
+115
+00:09:57,930 --> 00:10:02,250
+هيرتبط مع الـ NADH، في وجود إنزيم اسمه لكتات
+
+116
+00:10:02,250 --> 00:10:07,390
+ديهيدروجيناز، حيعطيني لكتات و NAD+، الـ Decrease في
+
+117
+00:10:07,390 --> 00:10:12,030
+الـ Absorbance، يعني الـ NADH تحولت لـ NAD+، صار لها
+
+118
+00:10:12,030 --> 00:10:15,390
+reduction، يعني حيصير في عندي Decrease في
+
+119
+00:10:15,390 --> 00:10:20,110
+الـ absorbance، هذا النقصان في الـ absorbance هنقرأه
+
+120
+00:10:20,110 --> 00:10:24,230
+على 340 nanometer، الـ wavelength، يعني في منطقة
+
+121
+00:10:24,230 --> 00:10:30,550
+الـ UV، وهذا التفاعل، والنقصان في الـ absorbance، هيعبر
+
+122
+00:10:30,550 --> 00:10:35,890
+عن الـ activity تبع الـ enzyme في العينة، برضه الـ
+
+123
+00:10:35,890 --> 00:10:41,310
+procedure مش مذكورة، هنذكرها لما نشتغل الفحص، طبعًا
+
+124
+00:10:41,310 --> 00:10:45,700
+إحنا بنرجع للجامعة، هنشتغل الـ ALT يا الـ AST، لأن
+
+125
+00:10:45,700 --> 00:10:48,300
+الإثنين نفس الـ procedure، تمام؟
+
+126
+00:10:56,930 --> 00:11:03,430
+الـ Normal Range لـ ALT عند الذكور من 13 لـ 35
+
+127
+00:11:03,430 --> 00:11:08,410
+International Unit Per Liter، عند الإناث من 10 لـ 30
+
+128
+00:11:08,410 --> 00:11:13,830
+International Unit Per Liter، High Serum Levels in
+
+129
+00:11:13,830 --> 00:11:19,790
+Acute Hepatitis، يعني الـ ALT بيكون موجود بتركيز
+
+130
+00:11:19,790 --> 00:11:23,130
+عالي جدًا في الـ Serum في حالات الـ Acute
+
+131
+00:11:23,130 --> 00:11:29,090
+Hepatitis (الالتهاب الحاد في خلايا الكبد)، تمام؟
+
+132
+00:11:29,090 --> 00:11:35,050
+بيصل تركيز الـ ALT في حالات الـ Acute Hepatitis من
+
+133
+00:11:35,050 --> 00:11:41,650
+300 لـ 1000 International Unit per Liter، تمام؟ الـ
+
+134
+00:11:41,650 --> 00:11:46,810
+ALT بيكون بتركيز عالي جدًا، موجود في السيرم عند
+
+135
+00:11:46,810 --> 00:11:50,570
+شخص اللي بيكون عنده التهاب حاد في الكبد، وبيصل
+
+136
+00:11:50,570 --> 00:11:56,590
+تركيز الإنزيم من 300 لـ 1000 IU per liter، لكن بيصير
+
+137
+00:11:56,590 --> 00:12:02,850
+له moderate elevation، الـ Moderate elevation يعني
+
+138
+00:12:02,850 --> 00:12:07,530
+الـ ALT بيصير له ارتفاع بشكل متوسط في حالات الـ
+
+139
+00:12:07,530 --> 00:12:11,130
+Alcohol Hepatitis، يعني Hepatitis معناها التهاب في
+
+140
+00:12:11,130 --> 00:12:15,370
+خلايا الكبد، Alcohol Hepatitis، إن اللي سبب التهاب
+
+141
+00:12:15,370 --> 00:12:20,660
+في خلايا الكبد، تناول الكحوليات، من 100 لـ 300
+
+142
+00:12:20,660 --> 00:12:24,620
+International Unit per Liter، بارتفاع الـ ALT في
+
+143
+00:12:24,620 --> 00:12:28,220
+السيرم في حالة الـ Alcohol Hepatitis، Minor
+
+144
+00:12:28,220 --> 00:12:33,780
+elevation (بارتفاع الـ ALT بشكل بسيط في حالات
+
+145
+00:12:33,780 --> 00:12:38,900
+التليف الكبدي)، تليف الكبد، الـ Hepatitis C، التهاب
+
+146
+00:12:38,900 --> 00:12:43,320
+الكبد نتيجة الفيروس
+
+147
+00:12:45,360 --> 00:12:52,320
+Hepatitis C، نتيجة فيروس، تلتهابت خلايا الكبد، وأيضًا في
+
+148
+00:12:52,320 --> 00:12:57,600
+حالة الـ Non-alcoholic Steatohepatitis، اللي اختصاره
+
+149
+00:12:57,600 --> 00:13:04,260
+NASH، الـ Non-alcoholic Steatohepatitis، هذا مرض، طبعًا
+
+150
+00:13:04,260 --> 00:13:10,660
+بيسموه مرض تشمع الكبد، تشمع الكبد، أنه الدهون بتبدأ
+
+151
+00:13:10,660 --> 00:13:15,860
+تتراكم على الـ liver، طبعًا الدهون بتبدأ تتراكم على
+
+152
+00:13:15,860 --> 00:13:21,110
+الـ liver، ومش بالضرورة يصيب الناس اللي بتناولوا كحول
+
+153
+00:13:21,110 --> 00:13:24,350
+يعني بيسموه non-alcoholic، يعني اللي بينصابوا فيه كمان
+
+154
+00:13:24,350 --> 00:13:28,490
+ما بيشربوا كحول، أنه نحكي مثلًا من الكحول هي عاملة
+
+155
+00:13:28,490 --> 00:13:34,350
+هذه المشكلة، هدول الأشخاص، المشكلة عندهم metabolic
+
+156
+00:13:34,350 --> 00:13:40,500
+syndrome، يعني سمنة، نتيجة الزيادة في الوزن، نتيجة
+
+157
+00:13:40,500 --> 00:13:44,560
+ارتفاع السكر في الدم، بميكانيزمات معينة، الدهون
+
+158
+00:13:44,560 --> 00:13:51,100
+عندهم تتراكم على الكبد، برضه هدول الأشخاص، بيصير
+
+159
+00:13:51,100 --> 00:13:55,660
+عندهم Minor elevation (ارتفاع بسيط في الـ ALT)
+
+160
+00:13:55,660 --> 00:14:00,280
+تقريبًا من 50 لـ 100 International Unit per Liter
+
+161
+00:14:00,280 --> 00:14:04,560
+بيرتفع طبعًا الـ Non-alcoholic steatohepatitis، لو
+
+162
+00:14:04,560 --> 00:14:09,460
+حبيتوا تعرفوا هذا المرض، ممكن على جوجل تشوفوه و
+
+163
+00:14:09,460 --> 00:14:17,400
+تبحثوا عنه، تمام، Levels of AST and ALT، AST is
+
+164
+00:14:17,400 --> 00:14:21,960
+assessed along with ALT، الـ Monitoring Liver Damage، يا
+
+165
+00:14:21,960 --> 00:14:28,000
+جماعة، ما بنطلب كل فحص لحاله، عادة الـ AST والـ ALT
+
+166
+00:14:28,000 --> 00:14:33,540
+الإثنين بينطلبوا مع بعض، عشان نشوف وضع الكبد
+
+167
+00:14:33,540 --> 00:14:39,610
+ونشوف هل حدث liver damage or not، تمام؟ These two
+
+168
+00:14:39,610 --> 00:14:44,990
+values normally exist in an approximately واحد
+
+169
+00:14:44,990 --> 00:14:51,250
+لواحد ratio، عند الإنسان الطبيعي الـ AST والـ ALT
+
+170
+00:14:51,250 --> 00:14:57,030
+الإثنين تقريبًا في السيرم نفس التركيز، فالـ ratio
+
+171
+00:14:57,030 --> 00:15:02,
+
+223
+00:19:30,430 --> 00:19:37,310
+كل الـ ALB عن الـ ALB الآخر. أنا في عندي ALB موجود في
+
+224
+00:19:37,310 --> 00:19:39,510
+الكبد، في الـ bone، في الـ placenta، في الـ
+
+225
+00:19:39,510 --> 00:19:44,870
+intestine. هذه كلها نظائر للإنزيم، كلها تتشارك مع
+
+226
+00:19:44,870 --> 00:19:49,790
+بعضها في خصائص و بتختلف مع بعضها في خصائص. كيف بدي
+
+227
+00:19:49,790 --> 00:19:55,190
+أفرق بينهم و أفصلهم؟ بتقنية الـ Electrophoresis
+
+228
+00:19:55,190 --> 00:20:00,010
+تفصل الـ ALB الأربعة اللي جاية من الكبد و الـ bone
+
+229
+00:20:00,010 --> 00:20:06,340
+و الـ placenta و الـ intestine، و بتحسب تركيز كل ALB
+
+230
+00:20:06,340 --> 00:20:09,880
+على حدة. يعني الـ ALB اللي جاي من الكبد بتم حساب
+
+231
+00:20:09,880 --> 00:20:14,260
+تركيزه، من الـ bone، من الـ placenta، من الـ intestine
+
+232
+00:20:14,260 --> 00:20:20,380
+بواسطة الـ Electrophoresis. بحكي للـ ALB هذا النظير
+
+233
+00:20:20,380 --> 00:20:24,980
+اللي بيكون في الكبد، على الـ Electrophoresis، على
+
+234
+00:20:24,980 --> 00:20:30,140
+الجل أو الـ cellulose acetate، بيمشي بشكل أسرع. لكن
+
+235
+00:20:30,140 --> 00:20:34,240
+الـ ALB اللي بيطلع من الـ intestine، في الـ
+
+236
+00:20:34,240 --> 00:20:37,680
+Electrophoresis أثناء الفصل، لما بيمشي بيكون قطة
+
+237
+00:20:37,680 --> 00:20:44,530
+واحدة. هذه من خصائصهم، تمام؟ أو تقنية أخرى هي
+
+238
+00:20:44,530 --> 00:20:48,810
+immunochemical. بيعتبروا أن الـ enzyme، هذا النظير
+
+239
+00:20:48,810 --> 00:20:53,700
+الـ ALB، Antigen. الـ Enzyme عبارة عن الـ Antigen.
+
+240
+00:20:53,700 --> 00:20:59,060
+بروحي جيبوا Antibody متخصص لهذا الـ Antigen. فالـ
+
+241
+00:20:59,060 --> 00:21:02,620
+Antibody بربط بالـ Enzyme و بعطيني Complex
+
+242
+00:21:02,620 --> 00:21:06,540
+(Antibody-Antigen Reaction). بحسب هذا الـ Complex
+
+243
+00:21:06,540 --> 00:21:14,040
+بطرق مناعية عشان أشوف تركيز الـ Enzyme، تمام؟ لكن يا
+
+244
+00:21:14,040 --> 00:21:21,160
+جماعة، هنا بدنا نركز على شغلة. الـ ALB موجود في الـ
+
+245
+00:21:21,160 --> 00:21:26,060
+serum تبع الإنسان بتركيز قليل جداً، زي الـ ALT
+
+246
+00:21:26,060 --> 00:21:33,920
+و الـ AST. لكن في حال إجاني شخص فحص له الـ ALB اللي
+
+247
+00:21:33,920 --> 00:21:38,220
+في الـ serum و لقيته عالي كتير كتير كتير، هذا
+
+248
+00:21:38,220 --> 00:21:44,000
+بيعطيك مؤشر على شو؟ إنه حدث damage في الـ organ.
+
+249
+00:21:44,000 --> 00:21:49,080
+طيب أي organ بالظبط؟ هل حدث damage في الـ liver ولا
+
+250
+00:21:49,080 --> 00:21:52,560
+في الـ bone ولا في الـ placenta ولا في الـ intestine؟
+
+251
+00:21:52,560 --> 00:21:58,860
+ما بتقدر تعرف من خلال الفحص، تمام؟ إذا فحص الـ ALP،
+
+252
+00:21:58,860 --> 00:22:04,220
+لو كان الـ ALP عالي كتير في الدم، بعطيكي مؤشر إن
+
+253
+00:22:04,220 --> 00:22:08,480
+هذا الشخص عنده tissue damage، عنده تدمير في الخلايا
+
+254
+00:22:08,480 --> 00:22:12,960
+وفي أعضاء معينة. طب إيش هذه الـ organ اللي صار إليها
+
+255
+00:22:12,960 --> 00:22:16,560
+damage؟ هل الكبد اتدمر؟ ولا الـ bone اتدمر؟ ولا
+
+256
+00:22:16,560 --> 00:22:19,700
+الـ placenta؟ ولا الـ intestine؟ ما هي أربع مناطق
+
+257
+00:22:19,700 --> 00:22:26,430
+فيهم ALP، ما بنعرف، تمام؟ لو بدي أعرف وين الدمج
+
+258
+00:22:26,430 --> 00:22:31,910
+بالظبط، بتروحي تعملي الـ Electrophoresis عشان تشوفي
+
+259
+00:22:31,910 --> 00:22:36,990
+الـ ALB اللي جاي من الكبد، و الـ ALB اللي جاي من
+
+260
+00:22:36,990 --> 00:22:40,070
+الـ bone، و الـ ALB اللي جاي من الـ placenta، و الـ ALB
+
+261
+00:22:40,070 --> 00:22:44,410
+اللي جاي من الـ intestine. مين أعلى واحد في التركيز؟
+
+262
+00:22:44,410 --> 00:22:49,920
+طبعاً في جهاز اسمه Densitometer بيحدد تركيز كل واحد
+
+263
+00:22:49,920 --> 00:22:54,180
+على حدة. فبتعرفي اللي أعلى في التركيز، معناه هذا
+
+264
+00:22:54,180 --> 00:22:58,700
+العضو هو اللي صار فيه الدمج، تمام؟ عشان هيك فحص الـ
+
+265
+00:22:58,700 --> 00:23:04,780
+ALP مش متخصص للكبد، بيرتفع في حالات مشاكل العظام،
+
+266
+00:23:04,780 --> 00:23:09,520
+مشاكل الـ placenta، مشاكل الأمعاء، تمام؟ هذه الشغلة
+
+267
+00:23:09,520 --> 00:23:15,030
+كتير ضرورية نفهمها. الـ Clinical Significance، بدنا
+
+268
+00:23:15,030 --> 00:23:20,650
+نحكي عن أهمية إنزيم الـ ALP، أهمية هذا الفحص.
+
+269
+00:23:20,650 --> 00:23:25,010
+Alkaline phosphatase is an enzyme found in the
+
+270
+00:23:25,010 --> 00:23:29,440
+liver, bone, placenta, intestine, and kidneys. الـ ALP
+
+271
+00:23:29,440 --> 00:23:33,800
+عبارة عن إنزيم موجود في الـ tissue كتيرة، في الكبد
+
+272
+00:23:33,800 --> 00:23:36,320
+و في الـ bone، و في الـ placenta، و الـ intestine، و الـ
+
+273
+00:23:36,320 --> 00:23:40,680
+kidneys. و لو قرأتم مقالة، هيحكيلكم إن الـ ALP موجود
+
+274
+00:23:40,680 --> 00:23:44,520
+في كل الـ organ، في كل الـ tissue اللي موجودة في
+
+275
+00:23:44,520 --> 00:23:49,580
+الجسم، فيها ALP، تمام؟ تركيزه في الدم قليل جداً، هذا
+
+276
+00:23:49,580 --> 00:23:55,410
+الوضع الطبيعي. لكن مكانه الأصلي جوات الخلايا.
+
+277
+00:23:55,410 --> 00:24:00,610
+Primarily in the cells lining the biliary tract.
+
+278
+00:24:00,610 --> 00:24:06,570
+يعني يا جماعة، كمان الـ ALP موجود في الخلايا اللي
+
+279
+00:24:06,570 --> 00:24:11,230
+بتكون الـ biliary tract، القناة الصفراوية. هالجُزء دي
+
+280
+00:24:11,230 --> 00:24:16,690
+اكم تتخيلوا معي، فوق في الكبد، اللي بيصل بين الكبد
+
+281
+00:24:16,690 --> 00:24:20,590
+والأمعاء اللي موجودة تحت، الـ intestine، قناة، القناة
+
+282
+00:24:20,590 --> 00:24:25,470
+الصفراوية، الـ biliary duct. إذن، في عندي كبد، وتحتها في
+
+283
+00:24:25,470 --> 00:24:30,270
+قناة صفراوية، biliary duct، وتحت القناة الصفراوية في
+
+284
+00:24:30,270 --> 00:24:34,990
+الأمعاء. هالجُزء، هذه الـ biliary duct، القناة الصفراوية،
+
+285
+00:24:34,990 --> 00:24:40,030
+الخلايا اللي فيها، هذه الخلايا أيضاً موجود فيها
+
+286
+00:24:40,030 --> 00:24:51,350
+الـ ALP، تمام؟ أيضاً هذه الخلايا اللي بتكون القناة
+
+287
+00:24:51,350 --> 00:24:57,410
+الصفراوية، لو اتكون في القناة stones، حصاوي، هذه
+
+288
+00:24:57,410 --> 00:25:03,010
+الحصاوي هتدمر الخلايا، وبالتالي الخلايا هتبدأ تفرز
+
+289
+00:25:03,010 --> 00:25:10,530
+ALP. إذاً، انتبهوا، الـ ALP موجود بشكل أساسي في الخلايا
+
+290
+00:25:10,530 --> 00:25:17,010
+اللي بتكون القناة الصفراوية. فلو اتكونت حصاوي في
+
+291
+00:25:17,010 --> 00:25:21,190
+القناة الصفراوية، هتأثر على الخلايا الموجودة هناك
+
+292
+00:25:21,190 --> 00:25:27,210
+وبالتالي تبدأ الخلايا تفرز ALP ويزيد تركيزه في
+
+293
+00:25:27,210 --> 00:25:31,850
+الدم. عشان هيك حكينا إن الـ ALP يعني بنعتبره مؤشر
+
+294
+00:25:31,850 --> 00:25:38,170
+لوجود كوليستاسيس، لوجود حصاوي في القناة الصفراوية. إذن
+
+295
+00:25:38,170 --> 00:25:42,610
+كمان شغلة بدي أحكيلكم إياها، إنه كمان لما بيصير عندي دمج
+
+296
+00:25:42,610 --> 00:25:47,310
+في خلايا الكبد، يعني خلايا الكبد اتدمرت، برضه الـ
+
+297
+00:25:47,310 --> 00:25:52,260
+ALP هيزيد في الدم. لأن الكبد برضه بفرز ALP، تمام؟
+
+298
+00:25:52,260 --> 00:25:57,400
+وبالتالي هيطلع الـ ALP من الكبد على الدم، ولكن بشكل
+
+299
+00:25:57,400 --> 00:26:02,720
+أكبر. الـ ALP بيزيد كتير كتير كتير لما بتتكون حصاوي
+
+300
+00:26:02,720 --> 00:26:07,040
+في القناة الصفراوية، لأن هذه الحصاوي اللي في
+
+301
+00:26:07,040 --> 00:26:11,700
+القناة هتأثر على الخلايا اللي في القناة، وبالتالي
+
+302
+00:26:12,360 --> 00:26:18,700
+هتبدأ تفرز ALP ويزيد تركيزه بشكل أكبر، تمام؟ أيضاً
+
+303
+00:26:18,700 --> 00:26:24,860
+الـ ALP بيكون موجود في الـ osteoblast، الخلايا
+
+304
+00:26:24,860 --> 00:26:30,340
+البنائية للعظم، تمام؟ Involved in the formation of
+
+305
+00:26:30,340 --> 00:26:34,310
+a new bone.  الجسم العظم لما بيتبنى يحتاج لـ
+
+306
+00:26:34,310 --> 00:26:39,690
+osteoblast، خلايا بناء عشان تبنيها. هذه الخلايا برضه
+
+307
+00:26:39,690 --> 00:26:47,190
+بتفرز ALP جواها، في ALP، تمام؟ فالـ ALP is normally
+
+308
+00:26:47,190 --> 00:26:53,030
+excreted from the liver in the bile. برضه الـ ALP
+
+309
+00:26:53,030 --> 00:27:00,190
+يا جماعة، بشكل طبيعي بيصير له excretion من الكبد إلى
+
+310
+00:27:00,190 --> 00:27:08,790
+الـ biliary duct، للقناة الصفراوية، بشكل طبيعي. زيادة
+
+311
+00:27:08,790 --> 00:27:16,370
+الـ ALP، زيادة الـ ALP، بنشوفه بشكل شائع عند الـ
+
+312
+00:27:16,370 --> 00:27:20,790
+bone growth، عند الـ children، الأطفال. الأطفال،
+
+313
+00:27:20,790 --> 00:27:24,870
+الأطفال،  مش بنحكي مرض، بيكونوا في مرحلة بناء للعظم
+
+314
+00:27:24,870 --> 00:27:29,390
+تبعهم، البناء، يعني خلايا الـ osteoblast بدها تبدأ
+
+315
+00:27:29,390 --> 00:27:34,070
+تشتغل، الخلايا البنائية، الخلايا هذه بتبدأ تفرز
+
+316
+00:27:34,070 --> 00:27:39,390
+أثناء بناء العظام، بتبدأ تفرز الـ ALP، لأنه فيها
+
+317
+00:27:39,390 --> 00:27:44,660
+ALP، تمام؟ وبالتالي عند الأطفال، لو فحصنا ALP، حالة
+
+318
+00:27:44,660 --> 00:27:49,260
+جاء عالي عندهم، مش عالي لأن عندهم حالات مرضية، عالي
+
+319
+00:27:49,260 --> 00:27:53,240
+لأنهم في مرحلة بناء، الـ osteoblast، الخلايا البنائية
+
+320
+00:27:53,240 --> 00:27:57,020
+للعظم تبدأ تشتغل عندهم، وبالتالي أثناء شغلها
+
+321
+00:27:57,020 --> 00:28:01,520
+بيصير في release للـ ALP، بيطلع الـ ALP على الدم
+
+322
+00:28:01,520 --> 00:28:07,100
+ويرتفع تركيزه. أيضاً الـ ALP بيرتفع في حالات liver
+
+323
+00:28:07,100 --> 00:28:11,180
+disease، مشاكل الكبد، لأنه أصلاً هو موجود في الكبد، صح
+
+324
+00:28:11,180 --> 00:28:15,140
+ولا لأ؟ فأي دمج في الكبد، هيطلع على الدم ويزيد
+
+325
+00:28:15,140 --> 00:28:19,460
+تركيزه. برضه الـ ALP بيزيد في حالات الـ biliary
+
+326
+00:28:19,460 --> 00:28:25,120
+obstruction، انسداد في القناة الصفراوية نتيجة تكوين
+
+327
+00:28:25,120 --> 00:28:29,610
+stones. حكينا القناة الصفراوية، لو اتكونت فيها حصاوي،
+
+328
+00:28:29,610 --> 00:28:35,870
+الخلايا اللي بتكون القناة، أصلاً فيها ALP، وبالتالي
+
+329
+00:28:35,870 --> 00:28:40,830
+وجود الحصاوي في هذه الخلايا، هيدمرها ويخليها تفرز
+
+330
+00:28:40,830 --> 00:28:47,640
+ALP منها للدم، تمام؟ إذن ثلاث حالات بيرتفع فيهم الـ
+
+331
+00:28:47,640 --> 00:28:52,700
+ALP: تكوين الـ stones في القناة الصفراوية، وجود مشكلة
+
+332
+00:28:52,700 --> 00:28:56,820
+في الكبد، حالات الـ growth اللي هي عند الأطفال بشكل
+
+333
+00:28:56,820 --> 00:29:02,780
+طبيعي. Serum ALP Activity Primarily Reflects
+
+334
+00:29:02,780 --> 00:29:06,740
+the changes in bone and liver function. طبعاً تركيز
+
+335
+00:29:06,740 --> 00:29:12,400
+الـ ALP، نشاط الـ ALP، بيعكس مدى التغيرات اللي بتصير
+
+336
+00:29:12,400 --> 00:29:17,340
+في الكبد و الـ bone، أكيد، لأنه أصلاً هو موجود في الكبد
+
+337
+00:29:17,340 --> 00:29:22,100
+وموجود في الـ bone، فأي مشكلة فيهم، في الـ liver أو في
+
+338
+00:29:22,100 --> 00:29:27,100
+الـ bone، هتأثر على تركيز الـ ALP. وبالتالي، حتى لو كان
+
+339
+00:29:27,100 --> 00:29:31,880
+هناك زيادة ALP أعلى، ممكن تجدها في أعضاء أخرى برضه،
+
+340
+00:29:31,880 --> 00:29:40,270
+الـ ALP موجودة في أعضاء أخرى، وبتركيز عالٍ، على
+
+341
+00:29:40,270 --> 00:29:44,110
+الرغم من أن الـ ALP، اتفقنا، موجود في كل الـ tissue،
+
+342
+00:29:44,110 --> 00:29:49,030
+في كل الـ organ، لكن فعلياً الـ activity تبعت الـ
+
+343
+00:29:49,030 --> 00:29:54,530
+ALP، أكثر شيء يعني، تتأثر في مشاكل الـ liver و الـ
+
+344
+00:29:54,530 --> 00:29:57,910
+bone، هم اللي بيحددوا تركيز الـ ALP، الـ liver و الـ
+
+345
+00:29:57,910 --> 00:30:02,350
+bone، على الرغم من أنه موجود في organs أخرى، بتركيز
+
+346
+00:30:02,350 --> 00:30:08,780
+عالي، تمام؟ Specimen collection، جمع العينة، a blood
+
+347
+00:30:08,780 --> 00:30:12,720
+sample should be drawn after a fast of at least 8 hours.
+
+348
+00:30:12,720 --> 00:30:18,140
+يعني لما بنعمل فحص الـ ALP، يفضل، يفضل أن نصوم 8
+
+349
+00:30:18,140 --> 00:30:22,980
+ساعات قبل إجراء الفحص. العينة serum أو بلازما. نوع الـ
+
+350
+00:30:22,980 --> 00:30:29,480
+anticoagulant المسموح فقط فيه هو الهيبارين. Slight
+
+351
+00:30:29,480 --> 00:30:35,440
+hemolysis is tolerable. يعني لما بيكون العينة أنت
+
+352
+00:30:35,440 --> 00:30:38,220
+شايفة فيها hemolysis، شايفة إنه فيه تكسير في
+
+353
+00:30:38,220 --> 00:30:42,060
+الـ RBCs، ولكن slight، بسيط أو خفيف، بقبلها،
+
+354
+00:30:42,060 --> 00:30:46,200
+tolerable، تمام. But gross hemolysis، لو جاتني عينة
+
+355
+00:30:46,200 --> 00:30:52,560
+الـ RBCs أغلبها مكسرة، gross hemolysis، gross يعني الـ
+
+356
+00:30:52,560 --> 00:30:56,360
+hemolysis كتير كتير شديد، هذه should be avoided.
+
+357
+00:30:56,360 --> 00:31:03,190
+يعني بأرفض العينة تماماً. إذن بفهم إن الـ ALP أيضاً
+
+358
+00:31:03,190 --> 00:31:07,190
+موجود جوة الـ RBCs، متفقين؟ موجود في كل أنسجة
+
+359
+00:31:07,190 --> 00:31:10,590
+الجسم تقريباً، هذا الـ enzyme موجود في كل أنسجة
+
+360
+00:31:10,590 --> 00:31:15,570
+الجسم، حتى الـ RBCs، تمام؟ الـ point الرابع من
+
+361
+00:31:15,570 --> 00:31:20,190
+الشريحة ما بدنا إياه. ننتقل للـ point الخامسة. It is
+
+362
+00:31:20,190 --> 00:31:24,630
+best to analyze ALP specimens the same day they
+
+363
+00:31:24,630 --> 00:31:29,290
+are drawn. يفضل ما نخزن العينة، يعني ما
+
+364
+00:31:29,290 --> 00:31:32,510
+نخزن الـ serum أو البلازما في الثلاجة أو بالفريزر
+
+365
+00:31:32,510 --> 00:31:36,310
+عشان أشتغل الـ ALP، ويفضل في اليوم اللي بجمع فيه
+
+366
+00:31:36,310 --> 00:31:41,830
+العينة، أفحص الـ enzyme على طول، تمام؟ الـ ALP is
+
+367
+00:31:41,830 --> 00:31:46,650
+inhibited by metal-complexing anticoagulants. إيش
+
+368
+00:31:46,650 --> 00:31:51,730
+يعني؟ يعني الـ EDTA، والأوكزاليت، والسترات، هذه الـ
+
+369
+00:31:51,730 --> 00:31:56,670
+anticoagulants ممنوع أسحب فيها، تمام؟ EDTA،
+
+370
+00:31:56,670 --> 00:32:01,410
+أوكزاليت، سترات، ممنوع أسحب فيهم. ليش؟ لأن كل هذه الـ
+
+371
+00:32:01,410 --> 00:32:07,250
+anticoagulants بتشتغل كـ chelating agents، بتشتغل
+
+372
+00:32:07,750 --> 00:32:12,830
+فتسحب المغنيسيوم، تمام؟ المغنيسيوم اتفقنا هذا الـ
+
+373
+00:32:12,830 --> 00:32:18,930
+co-factor للـ ALP، هو المسؤول عن نشاط إنزيم الـ ALP.
+
+374
+00:32:18,930 --> 00:32:23,690
+فلو انسحب المغنيسيوم، لو أنا يا جماعة عينت الدم
+
+375
+00:32:23,690 --> 00:32:28,010
+بـ EDTA أو أوكساليت أو سترات، هذه الـ anticoagulants
+
+376
+00:32:28,010 --> 00:32:31,920
+بتشتغل chelating agents، بتسحب المغنيسيوم، وبالتالي
+
+377
+00:32:31,920 --> 00:32:35,120
+الـ ALP مش هيشتغل، الـ enzyme مش هيشتغل على الـ
+
+378
+00:32:35,120 --> 00:32:39,440
+substrate تبعته، لأن الـ cofactor تم سحبه. عشان هيك
+
+379
+00:32:39,440 --> 00:32:44,180
+ممنوعة هذه الـ anticoagulants، لإنه بتعمل inhibit للـ
+
+380
+00:32:44,180 --> 00:32:50,080
+enzyme، بتثبط الـ ALP. كيف بتثبته؟ من خلال إنها بتسحب
+
+381
+00:32:50,080 --> 00:32:55,420
+المغنيسيوم. عشان هيك ممنوع الجمع بهذه الـ
+
+382
+00:32:55,420 --> 00:33:01,500
+anticoagulants. Assay for enzyme activity، بدنا نشوف
+
+383
+00:33:01,500 --> 00:33:06,740
+الطرق المستخدمة لقياس نشاط الـ ALP. Almost all
+
+384
+00:33:06,740 --> 00:33:11,520
+assays for ALP employ p-nitrophenyl phosphate as
+
+385
+00:33:11,520 --> 00:33:16,660
+the substrate. تقريباً كل الطرق، وكل الـ kits، الـ
+
+386
+00:33:16,660 --> 00:33:20,820
+reagents بيحتوي على الـ substrate. إيش هذه الـ
+
+387
+00:33:20,820 --> 00:33:25,840
+substrate؟ اسمها الـ p-nitrophenyl phosphate. هذه
+
+388
+00:33:25,840 --> 00:33:32,030
+الـ substrate تبع إنزيم الـ ALP، تمام؟ هالجُزء،
+
+389
+00:33:32,030 --> 00:33:35,330
+انتبهوا، تحت في الـ reaction، بدنا نتخيل كيف
+
+390
+
+445
+00:38:12,190 --> 00:38:16,820
+الـ group؟ هو الـ Gamma Glutamyl، الـ GGT بيحكيلك
+
+446
+00:38:16,820 --> 00:38:20,880
+موجود بتركيز عالي جداً في الـ liver; it is a high
+
+447
+00:38:20,880 --> 00:38:24,600
+concentration in liver tissue. موجود بتركيز عالي
+
+448
+00:38:24,600 --> 00:38:28,760
+جداً في الكبد، أيضاً موجود في الـ kidney، وموجود في
+
+449
+00:38:28,760 --> 00:38:33,260
+الـ pancreas، وأضيفوا عليها: موجود أيضاً في الخلايا
+
+450
+00:38:33,260 --> 00:38:39,880
+التي تُكوّن الـ biliary tract، القنوات الصفراوية، تمام؟
+
+451
+00:38:39,880 --> 00:38:46,680
+وموجود في الدم بالوضع الطبيعي بتركيز قليل. الـ
+
+452
+00:38:46,680 --> 00:38:50,520
+Diagnostic Significance: أهمية فحص الـ GGT
+
+453
+00:38:50,520 --> 00:38:54,880
+Increased plasma GGT is associated with
+
+454
+00:38:54,880 --> 00:38:59,980
+hepatobiliary disease. يعني الـ GGT يا جماعة بيرتفع
+
+455
+00:38:59,980 --> 00:39:06,260
+لما بيصير فيه damage، أو حصوات (stones) في
+
+456
+00:39:06,260 --> 00:39:10,100
+الـ Biliary Tract، في القناة الصفراوية، وبالتالي
+
+457
+00:39:10,100 --> 00:39:14,300
+الحصوات ستؤثر على الخلايا الموجودة في هذه المنطقة.
+
+458
+00:39:14,300 --> 00:39:20,020
+هذه الخلايا ستبدأ بإفراز، ستفرز الـ GGT للبلازما،
+
+459
+00:39:20,020 --> 00:39:26,160
+تمام؟ Highest seen in biliary obstruction. في
+
+460
+00:39:26,160 --> 00:39:31,460
+حالات الانسداد في القنوات الصفراوية بسبب تكوين
+
+461
+00:39:31,460 --> 00:39:35,680
+stones، بيكون يعني تركيزه عالي جداً جداً أيضاً في
+
+462
+00:39:35,680 --> 00:39:39,380
+حالات الـ Alcohol cirrhosis، تليف الكبد الذي
+
+463
+00:39:39,380 --> 00:39:44,020
+سببه تناول الكحول، أيضاً يرتفع الـ GGT في البلازما.
+
+464
+00:39:44,840 --> 00:39:50,500
+فحص الـ GGT يُستخدم مع ALB، يعني يُجرى
+
+465
+00:39:50,500 --> 00:39:54,760
+الاثنان معاً to differentiate between liver and
+
+466
+00:39:54,760 --> 00:39:59,420
+bone disease، عشان نميز هل المشكلة في الكبد أم
+
+467
+00:39:59,420 --> 00:40:02,580
+المشكلة في العظام.  خلّيني أركز على هذه النقطة، لأنها
+
+468
+00:40:02,580 --> 00:40:07,660
+كتير مهمة. حكينا أن الـ ALB موجود في الكبد وموجود
+
+469
+00:40:07,660 --> 00:40:13,390
+في العظام، لكن الـ GGT موجود في الكبد فقط،  ليس موجوداً في
+
+470
+00:40:13,390 --> 00:40:17,570
+العظام.  فانت لما بتعمل الاثنين معاً، تخيل إيجاني
+
+471
+00:40:17,570 --> 00:40:22,530
+مريض، عملت له فحص ALB و GGT، الاثنان معاً، وطلع الاثنان
+
+472
+00:40:22,530 --> 00:40:28,250
+عالِيين جداً، معناه أكيد في عندي مشكلة في الكبد، مشكلة
+
+473
+00:40:28,250 --> 00:40:31,430
+في القنوات الصفراوية، فيها حصوات.  لما يكون الاثنان
+
+474
+00:40:31,430 --> 00:40:36,190
+عالِيين، تمام؟ لكن إيجاني مريض آخر، عملت له الاثنين
+
+475
+00:40:36,190 --> 00:40:41,940
+معاً، الـ ALB والـ GGT، طلع الـ ALB عنده عالياً، لكن الـ
+
+476
+00:40:41,940 --> 00:40:48,820
+GGT طبيعي، إذن هذا يؤكد أنه لديه مشكلة في
+
+477
+00:40:48,820 --> 00:40:53,040
+العظام، مشكلة في العظام. الـ GGT عنده طبيعي،
+
+478
+00:40:53,040 --> 00:40:57,960
+يعني القنوات الصفراوية لديه طبيعية، والكبد لديه
+
+479
+00:40:57,960 --> 00:41:03,060
+طبيعي. إذن ارتفاع الـ ALB وحده، يُعتبر indication
+
+480
+00:41:03,060 --> 00:41:07,230
+أن المشكلة في العظام، لأنه وحده موجود في الـ bone
+
+481
+00:41:07,230 --> 00:41:12,550
+... يعني ليس الـ GGT، تمام؟ إذاً لو عملت الفحصين
+
+482
+00:41:12,550 --> 00:41:16,690
+معاً، والاثنان طلعا عالِيين، إذن أكيد المشكلة في
+
+483
+00:41:16,690 --> 00:41:20,890
+الكبد وفي القنوات الصفراوية. لو عملت الفحصين معاً
+
+484
+00:41:20,890 --> 00:41:26,630
+والـ ALB كان عالياً، والـ GGT كان طبيعياً، إذن أكيد
+
+485
+00:41:26,630 --> 00:41:30,490
+المشكلة تكون في الـ bone، في العظم، تمام؟
+
+486
+00:41:32,760 --> 00:41:35,900
+الـ "Say for enzyme activity" بدنا نشوف الطرق
+
+487
+00:41:35,900 --> 00:41:39,940
+المستخدمة لقياس الـ enzyme. كمان يا جماعة، كيتاتنا
+
+488
+00:41:39,940 --> 00:41:46,440
+التي تفحص الـ GGT، أيضاً  colorimetric reaction، مثل
+
+489
+00:41:46,440 --> 00:41:50,100
+فحص الـ ALB تماماً.  لذلك، عندما نعود إلى الجامعة
+
+490
+00:41:50,100 --> 00:41:54,980
+سوف نعمل واحداً منهما، سنعمل إما ALP أو GGT، لكن ما
+
+491
+00:41:54,980 --> 00:41:59,280
+هو متوفر لدينا في الجامعة هو ALP، تمام؟ لكن هذا لا
+
+492
+00:41:59,280 --> 00:42:02,400
+يمنع أن نرى التفاعل، كيف يكون التفاعل،
+
+493
+00:42:02,400 --> 00:42:06,200
+انتبهوا على الصندوق الأزرق. هلجيت، الـ Serum  للمريض
+
+494
+00:42:06,200 --> 00:42:09,940
+يحتوي على الـ GGT، يحتوي على الـ enzyme،
+
+495
+00:42:09,940 --> 00:42:14,280
+تمام؟ وأنا أريد فحص activity  لها. هلجيت الـ
+
+496
+00:42:14,280 --> 00:42:19,440
+reaction، يحتوي على الـ substrate التي سيُكسرها الـ
+
+497
+00:42:19,440 --> 00:42:25,200
+enzyme. الـ substrate هي الـ L-Gamma-Glutamyl-p-Nitro-anilide
+
+498
+00:42:25,200 --> 00:42:32,640
+زائد Glycyl-Glycine. هذه كلها الـ
+
+499
+00:42:32,640 --> 00:42:37,140
+substrate الموجودة في الـ reagent، سيعمل عليها الـ
+
+500
+00:42:37,140 --> 00:42:41,680
+enzyme الموجود في الـ serum، ومحصلة التفاعل
+
+501
+00:42:41,680 --> 00:42:48,280
+ستعطيني مادة تُسمى الـ p-Nitroaniline و الـ Gamma
+
+502
+00:42:48,280 --> 00:42:55,350
+Glutamyl Glycylglycine. إذن محصلة التفاعل: إعطاء مادة
+
+503
+00:42:55,350 --> 00:43:01,470
+ملونة، الـ p-Nitroaniline، وشدة اللون الذي تكون،
+
+504
+00:43:01,470 --> 00:43:06,790
+نتيجة محصلة التفاعل، ستتناسب تناسباً طردياً مع نشاط الـ
+
+505
+00:43:06,790 --> 00:43:12,030
+enzyme في العينة. ومادة الـ p-Nitroaniline سنقرأها
+
+506
+00:43:12,030 --> 00:43:18,020
+على wavelength 405 نانومتر. الـ Reference Range عند
+
+507
+00:43:18,020 --> 00:43:23,120
+الرجال من 6 إلى 45 International Unit Per Liter، عند
+
+508
+00:43:23,120 --> 00:43:28,260
+الإناث من 5 إلى 30 International Unit Per Liter. إذن،
+
+509
+00:43:28,260 --> 00:43:31,540
+المادة المتفاعلة: إن السيروم يحتوي على الإنزيم
+
+510
+00:43:31,540 --> 00:43:35,640
+والـ reagent يحتوي على الـ substrate، عندما أضعهما معاً، الـ
+
+511
+00:43:35,640 --> 00:43:39,620
+enzyme يُكسر الـ substrate. محصلة التفاعل مادة
+
+512
+00:43:39,620 --> 00:43:43,940
+ملونة، نقيس هذه المادة على wavelength معينة،
+
+513
+00:43:43,940 --> 00:43:48,160
+وشدة اللون ستتناسب تناسباً طردياً مع activity  الـ
+
+514
+00:43:48,160 --> 00:43:54,240
+enzyme. وبهذه نكون قد أنهينا  chapter liver function
+
+515
+00:43:54,240 --> 00:43:55,940
+tests، ويعطيكم ألف عافية.
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/OEKZUS3N-iI_postprocess.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/OEKZUS3N-iI_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..4aac5a1c5f9e25faf2cad60625eecc1e47458e3c
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/OEKZUS3N-iI_postprocess.srt
@@ -0,0 +1,2060 @@
+1
+00:00:00,770 --> 00:00:04,750
+هنحكي هنا عن الفحص التاني اللي بيشيك على الـ
+
+2
+00:00:04,750 --> 00:00:08,670
+Hepatocellular injury هل خلايا الكبد فيها damage
+
+3
+00:00:08,670 --> 00:00:13,530
+ولا لأ الإنزايم الآخر الـALT Alanine
+
+4
+00:00:13,530 --> 00:00:18,270
+Aminotransferasea transferase with enzymatic
+
+5
+00:00:18,270 --> 00:00:23,410
+activity similar to AST شغلوا يا جماعة نفس شغل الـ
+
+6
+00:00:23,410 --> 00:00:29,650
+AST إيه شغلهم؟ ينجلق أمين جروب مجموعة أمين من مكان
+
+7
+00:00:29,650 --> 00:00:37,360
+لمكان آخر، تمام؟Converts هذا الـ ALT يحول الألانين
+
+8
+00:00:37,360 --> 00:00:42,440
+والألفا كيتو إجلوتارات إلى مادة البيروفات
+
+9
+00:00:42,440 --> 00:00:46,840
+والجلوتامات زي ما انتوا شايفين هي الـ Amino Acid
+
+10
+00:00:46,840 --> 00:00:52,380
+الحمض الأميني الألانين مع الألفا كيتو إجلوتارات في
+
+11
+00:00:52,380 --> 00:00:57,100
+وجود الـ ALT إنزايم إيش بيعمل؟ بنزع الـ Amino
+
+12
+00:00:57,100 --> 00:01:01,630
+Groupاللي موجودة في الحند الأمين الألانين وبياخدها
+
+13
+00:01:01,630 --> 00:01:06,690
+وبينجلها على المركب الآخر الـ αكيتو إجلوتاريت
+
+14
+00:01:06,690 --> 00:01:13,410
+محصلة النقل إن الألانين هيتحول لـ Pyruvate والـ
+
+15
+00:01:13,410 --> 00:01:18,670
+αكيتو إجلوتاريت هذه المادة هتتحول لـ Glutamate
+
+16
+00:01:18,670 --> 00:01:25,130
+طبعا مش هطلبكوا في المعادلة وفي التحويل بس للعلم و
+
+17
+00:01:25,130 --> 00:01:31,030
+للفهمالـ Clinical Significance للفحص الأهمية
+
+18
+00:01:31,030 --> 00:01:35,590
+التشخيصية لفحص الـ ALT it is found in the kidneys,
+
+19
+00:01:35,910 --> 00:01:39,910
+heart and skeletal muscle tissue but primarily in
+
+20
+00:01:39,910 --> 00:01:44,030
+the liver tissue بيحكيلي إنزايم الـ ALT وين
+
+21
+00:01:44,030 --> 00:01:47,910
+الأماكن اللي بيكون موجود فيها بشكل أساسي موجود في
+
+22
+00:01:47,910 --> 00:01:53,470
+الكدن والهارت والسكلتال muscle وال RBCs ضيفه كمان
+
+23
+00:01:53,620 --> 00:01:57,400
+الـ Red Blood Cell خلاية الدم الحمراء موجود في هذه
+
+24
+00:01:57,400 --> 00:02:02,760
+الأماكن يا جماعة بتركيز قليلة جدا لا تسكر تمام؟
+
+25
+00:02:02,760 --> 00:02:07,680
+لكنه موجود بطي primarily ولكن بشكل أساس الـ ALT
+
+26
+00:02:07,680 --> 00:02:12,600
+موجود في خلايا الكبط إذا الـ ALT موجود في الـ
+
+27
+00:02:12,600 --> 00:02:16,280
+kidney والـ heart والـ skeletal muscle والـ RBCs
+
+28
+00:02:16,840 --> 00:02:22,080
+بكميات قليلة جدا لكن فيه ال liver tissue موجود ب
+
+29
+00:02:22,080 --> 00:02:28,040
+high concentration بتركيز عالية تمام في الدم في ال
+
+30
+00:02:28,040 --> 00:02:34,220
+serum زي زي ال AST ال ALT موجود بتركيز قليل جدا
+
+31
+00:02:34,220 --> 00:02:38,960
+هذا الإنسان الطبيعي ال ALT يكون موجود في ال serum
+
+32
+00:02:38,960 --> 00:02:43,830
+ولكن بتركيز قليل لكن وين موجودأكتر إشي في الـ
+
+33
+00:02:43,830 --> 00:02:48,910
+tissue، في الأنثجا، تمام؟ وبشكل أساسي في الكبت الـ
+
+34
+00:02:48,910 --> 00:02:52,470
+test is used mainly in the diagnosis of liver
+
+35
+00:02:52,470 --> 00:02:55,990
+disease and to monitor the effects of hepatotoxic
+
+36
+00:02:55,990 --> 00:03:01,850
+drug الفحص بينعمل بشكل أساسي فحص ال ALT عشان نشخص
+
+37
+00:03:01,850 --> 00:03:06,930
+المشاكل الكبت وخاصة المشاكل اللي بتصيب الخلايا،
+
+38
+00:03:06,930 --> 00:03:13,700
+تمام؟وأيضًا عشان نتابع تأثير الأدوية السامة على
+
+39
+00:03:13,700 --> 00:03:19,260
+الكبد أحيانًا في الـ Drug ممكن بعض الأدوية تأثر
+
+40
+00:03:19,260 --> 00:03:24,520
+على الكبد تمام؟ وتأثر على خلايا الكبد وتعمل injury
+
+41
+00:03:24,520 --> 00:03:30,040
+فيها فإحنا من خلال فحص الـ ALT بنتابع هذه الأدوية
+
+42
+00:03:30,040 --> 00:03:35,940
+تمام؟often higher than AST with liver damage and
+
+43
+00:03:35,940 --> 00:03:42,780
+tend to remain elevated longer هنا بيحكيلي الـ ALT
+
+44
+00:03:42,780 --> 00:03:48,220
+عادة تركيزه أعلى من الـ AST في حالات liver damage
+
+45
+00:03:48,220 --> 00:03:53,160
+يعني لو صار عندي مشكلة في الكبت liver damageالـ
+
+46
+00:03:53,160 --> 00:03:57,720
+AST والـ ALT التانيين موجودين في الكبت، تمام؟ بس
+
+47
+00:03:57,720 --> 00:04:02,220
+مين موجود أكتر في الكبت الـ ALT؟ الـ ALT موجود في
+
+48
+00:04:02,220 --> 00:04:06,700
+الكبت بتركيز عالي كتير، أعلى من الـ AST فلما بيصير
+
+49
+00:04:06,700 --> 00:04:11,860
+عندي مشكلة في الكبت، هيطلع الـ ALT والـ AST لبرا،
+
+50
+00:04:11,860 --> 00:04:17,110
+ع الدم، تمام؟وبالتالي الـ ALT و الـ AST التنين
+
+51
+00:04:17,110 --> 00:04:22,050
+هيزيدوا في الدم بس الـ ALT هيزيد أكتر من الـ AST
+
+52
+00:04:22,050 --> 00:04:28,250
+لأنه أصلا هو تركيزه في الـ liver أكتر وأعلى
+
+53
+00:04:28,250 --> 00:04:32,690
+وبالتالي لما يطلعوا الإتنين ع الدم الـ ALT و الـ
+
+54
+00:04:32,690 --> 00:04:38,510
+AST بيزيدوا بس الـ ALT بيكون أعلى من الـ AST تمام؟
+
+55
+00:04:38,510 --> 00:04:44,250
+أيضا كمان شغلةإذاً كمان شغلة تانية بدنا نعرفها إنه
+
+56
+00:04:44,250 --> 00:04:49,090
+غير إن الـ ALT بيكون أعلى من الـ AST في حالات
+
+57
+00:04:49,090 --> 00:04:54,390
+liver damage كمان الـ ALT بيظلوا عالي في الدم
+
+58
+00:04:54,390 --> 00:05:02,690
+لفترة أطول من الـ AST حكينا إنه يعنيmore liver
+
+59
+00:05:02,690 --> 00:05:07,930
+يعني كمان شغلة تانية more liver specific than AST
+
+60
+00:05:07,930 --> 00:05:13,510
+إذا في تلت شغلات بدنا ناخدها بعين الاعتبار ال ALT
+
+61
+00:05:13,510 --> 00:05:18,050
+في الكبد تركيزه أعلى من ال AST فلما بيصير liver
+
+62
+00:05:18,050 --> 00:05:24,070
+damage التنين بيطلعوا على الدم لكن في الدم ال ALT
+
+63
+00:05:24,070 --> 00:05:30,490
+هيكون تركيزه أعلى من ال ASTومش بس هيك كمان الـ ALT
+
+64
+00:05:30,490 --> 00:05:37,150
+بيظل عالي لفترة طويلة أطول من الـ AST يعني ممكن
+
+65
+00:05:37,150 --> 00:05:43,270
+بعد خمس، ست أيام الـ AST يرجع طبيعي ويظل الـ ALT
+
+66
+00:05:43,270 --> 00:05:49,150
+عالي في الـ Serumتمام شغلة تالتة بيحكيلنا إن الـ
+
+67
+00:05:49,150 --> 00:05:57,230
+ALT يعتبر متخصص أكتر من الـ AST متخصص للكبد فحص
+
+68
+00:05:57,230 --> 00:06:03,700
+الـ ALT متخصص أكتر في الكبدمن فحص ال ASC تفاجنا إن
+
+69
+00:06:03,700 --> 00:06:09,280
+ال ASC مش متخصص برتفع في حالات الدبح القلبية برتفع
+
+70
+00:06:09,280 --> 00:06:14,860
+في حالات مشاكل الكبد لكن ال ALT بقولك remains
+
+71
+00:06:14,860 --> 00:06:20,040
+normal in acute myocardial infarction يبقى طبيعي
+
+72
+00:06:20,040 --> 00:06:25,400
+في حالات الذبح القلبية إذن هو متخصص أكتر إشي للكبد
+
+73
+00:06:25,960 --> 00:06:30,260
+ليش يا جماعة، مع إنه هتسألوني، هتحكولي طيب الـ ALT
+
+74
+00:06:30,260 --> 00:06:34,880
+هيه موجود في القلب حكيناه، وفي الـ kidney طيب ليش
+
+75
+00:06:34,880 --> 00:06:39,140
+في حالات الدبح القلبية ما بيزيد؟ لإنه حكيتلكم هو
+
+76
+00:06:39,140 --> 00:06:42,200
+موجود في الـ kidney و الـ heart و الـ skeletal
+
+77
+00:06:42,200 --> 00:06:48,420
+muscle و الـ RBCs بكميات قليلة جداًمش زي الـ AST،
+
+78
+00:06:48,420 --> 00:06:52,760
+الـ AST موجود في هذه التشوب كميات أكبر وبالتالي
+
+79
+00:06:52,760 --> 00:06:56,680
+الـ ALT موجود في عضلة القلب ولكن كميات قليلة، يعني
+
+80
+00:06:56,680 --> 00:07:00,320
+لما بيصير دمش في القلب ويطلع الـ ALT على الـ
+
+81
+00:07:00,320 --> 00:07:05,220
+Serum، على الدم، مش كتير هيزيد تركيزه أو هيفرج
+
+82
+00:07:05,220 --> 00:07:09,020
+معاه، تمام؟ وبالتالي بيضلوا ضمن الـ Normal Range،
+
+83
+00:07:09,020 --> 00:07:15,020
+إذا فحص الـ ALT متخصص أكتر من فحص الـ AST للكبد
+
+84
+00:07:17,040 --> 00:07:21,580
+الـ Specimen Collection نوع العينة زي الـ AST سيرم
+
+85
+00:07:21,580 --> 00:07:25,140
+أو بلازمة البلازمة نوع الـ Anticoagulant إدتا أو
+
+86
+00:07:25,140 --> 00:07:30,820
+هيبرين تمام؟ لأنه كمان الـ ALT موجود جوات الـ RBCs
+
+87
+00:07:30,820 --> 00:07:35,240
+يعني بدي أتجنب أجمع عينة Hemolyse و العينة الـ
+
+88
+00:07:35,240 --> 00:07:39,660
+Hemolyse بدي أعملها rejection أرفضها ليش؟ لأنه لو
+
+89
+00:07:39,660 --> 00:07:44,600
+العينة سرقلها Hemolysis هيطلع الـ ALT من الـ RBCs
+
+90
+00:07:44,600 --> 00:07:48,630
+على السيرمويزيد تركيزه في الـ Serum بشكل خاطئ
+
+91
+00:07:48,630 --> 00:07:56,770
+معلومة إن الـ ALT موجود بالـ RBCs تقريبا بـ 5
+
+92
+00:07:56,770 --> 00:08:01,010
+أضعاف الـ ALT اللي موجود في الـ Serum يعني هو
+
+93
+00:08:01,010 --> 00:08:07,090
+موجود في الـ RBCs ولكن 5 أضعاف، تمام؟ لو بتتذكروا
+
+94
+00:08:07,090 --> 00:08:13,600
+الـ AST موجود الـ AST في الـ RBCs بـ 15 دعفيعني
+
+95
+00:08:13,600 --> 00:08:19,880
+الـ AST موجود في الـ RBCs بكميات أكبر من الـ ALT
+
+96
+00:08:19,880 --> 00:08:25,020
+تمام؟ هذه معلومة مهمة الـ AST موجود في الـ RBCs
+
+97
+00:08:25,020 --> 00:08:31,740
+بكميات أكبر من الـ ALT الـ «Say for enzyme
+
+98
+00:08:31,740 --> 00:08:36,140
+activity» قياس الـ activity تبعة الإنزايم الطرق
+
+99
+00:08:36,140 --> 00:08:41,460
+المستخدمة في قياس الـ activity تبعة إنزايم الـ ALT
+
+100
+00:08:42,350 --> 00:08:48,250
+طبعا الطريقة ومبدأ الشغل نفس مبدأ شغل الـ AST مش
+
+101
+00:08:48,250 --> 00:08:52,030
+هي أنزمات كلها نفس المبدأ الكلام المكتوب بالـ
+
+102
+00:08:52,030 --> 00:08:58,330
+slide تلخيصه في المربع اللي تحت الأبيض هذا الـ
+
+103
+00:08:58,330 --> 00:09:02,430
+principle مبدأ الفحص نفس الـ AST بالظبط يا جماعة
+
+104
+00:09:03,290 --> 00:09:07,070
+الـ Serum تبع ال patient بيكون فيه الـ ALT الـ
+
+105
+00:09:07,070 --> 00:09:10,490
+enzyme اللي أنا بدي أحسب ال activity تبعته بدي
+
+106
+00:09:10,490 --> 00:09:15,390
+أحسب نشاطه لأنه نشاطه هيعبر عن الـ concentration
+
+107
+00:09:15,390 --> 00:09:25,350
+لهذا الـ enzyme تمام؟ هلجيت؟ الألانين والألفا
+
+108
+00:09:25,350 --> 00:09:32,870
+كيتو إجلترات هذي substrate موجودة في الـ reagentهل
+
+109
+00:09:32,870 --> 00:09:35,990
+جات الألانين حكيناه والـ Alpha-ketoglutarate
+
+110
+00:09:35,990 --> 00:09:40,950
+سبستريت هذه المواد موجودة في الـ Reagent لما نخلط
+
+111
+00:09:40,950 --> 00:09:45,710
+الـ Reagent على عينة المريض على السيرام الـ ALT
+
+112
+00:09:45,710 --> 00:09:49,670
+الموجود في السيرام هيشتغل على السبستريت اللي
+
+113
+00:09:49,670 --> 00:09:53,630
+موجودة في الـ Reagent ويحول الألانين لـ Pyruvate
+
+114
+00:09:53,630 --> 00:09:57,930
+والـ Alpha-ketoglutarate لـ Glutamateالبيروفيات
+
+115
+00:09:57,930 --> 00:10:02,250
+هيرتبط مع الـ NADH في وجود إنذايم اسمه لكتات
+
+116
+00:10:02,250 --> 00:10:07,390
+ديهيدروجيناذ حيعطيني لكتات و NADH الـ Decrease في
+
+117
+00:10:07,390 --> 00:10:12,030
+الـ Absorbance يعني الـ NADH اتحولت لـ NADH صارلها
+
+118
+00:10:12,030 --> 00:10:15,390
+reductionيعني حيصير في عندي decrease في
+
+119
+00:10:15,390 --> 00:10:20,110
+الـabsorbance هذا النقصان في الـabsorbance هنقرأه
+
+120
+00:10:20,110 --> 00:10:24,230
+على 340 nanometer الـ wavelength يعني في منطقة
+
+121
+00:10:24,230 --> 00:10:30,550
+الـUV وهذا التفاعل والنقصان في الـabsorbance هيعبر
+
+122
+00:10:30,550 --> 00:10:35,890
+عن الـactivity تبعة الـenzyme في العينة برضه ال
+
+123
+00:10:35,890 --> 00:10:41,310
+procedure مش مذكورة هنذكرها لما نشتغل الفحص طبعا
+
+124
+00:10:41,310 --> 00:10:45,700
+احنا بنرجع الجامعةيا هنشتغل الـ ALT يا الـ AST لأن
+
+125
+00:10:45,700 --> 00:10:48,300
+الاتنين نفس الـ procedure تمام؟
+
+126
+00:10:56,930 --> 00:11:03,430
+الـ Normal Range لـ ALT عند المال من 13 ل 35
+
+127
+00:11:03,430 --> 00:11:08,410
+International Unit Per Liter عند الفمان من 10 ل 30
+
+128
+00:11:08,410 --> 00:11:13,830
+International Unit Per Liter High Serum Levels in
+
+129
+00:11:13,830 --> 00:11:19,790
+Acute Hepatitis يعني الـ ALTبيكون موجود بتركيز
+
+130
+00:11:19,790 --> 00:11:23,130
+عالي جداً في الـ Serum في حالات الـ Acute
+
+131
+00:11:23,130 --> 00:11:29,090
+Hepatitis الالتهاب الحاد في خلايا الكبد، تمام؟
+
+132
+00:11:29,090 --> 00:11:35,050
+بيصل تركيز الـ ALT في حالات الـ Acute Hepatitis من
+
+133
+00:11:35,050 --> 00:11:41,650
+300 لـ 1000 International Unit per Liter، تمام؟الـ
+
+134
+00:11:41,650 --> 00:11:46,810
+ALT بيكون بتركيز عالي جدًا موجود في السيرام عند
+
+135
+00:11:46,810 --> 00:11:50,570
+شخص اللي بيكون عنده التهاب حاد في الكبد وبيصل
+
+136
+00:11:50,570 --> 00:11:56,590
+تركيز الانزين من 300 ل1000 IU per liter لكن بيصير
+
+137
+00:11:56,590 --> 00:12:02,850
+له moderate elevationالـ Moderate elevation يعني
+
+138
+00:12:02,850 --> 00:12:07,530
+الـ ALT بيصيرله ارتفاع بشكل متوسط في حالات الـ
+
+139
+00:12:07,530 --> 00:12:11,130
+Alcohol Hepatitis يعني Hepatitis معناه التهاب في
+
+140
+00:12:11,130 --> 00:12:15,370
+خلايا الكبد Alcohol Hepatitis ان اللي سبب التهاب
+
+141
+00:12:15,370 --> 00:12:20,660
+في خلايا الكبد تناول الكحولاتمن 100 لـ 300
+
+142
+00:12:20,660 --> 00:12:24,620
+International Unit per Liter بارتفاع الـ ALT في
+
+143
+00:12:24,620 --> 00:12:28,220
+السيرام في حالة الـ Alcohol Hepatitis Minor
+
+144
+00:12:28,220 --> 00:12:33,780
+elevation بارتفاع الـ ALT بشكل بسيط في حالات
+
+145
+00:12:33,780 --> 00:12:38,900
+السيروسيز تليفات الكبد الـ Hepatitis C التهاب
+
+146
+00:12:38,900 --> 00:12:43,320
+الكبد نتيجة الفيروس
+
+147
+00:12:45,360 --> 00:12:52,320
+Hepatitis C نتيجة فيروس تلتهب خلايا الكبد وأيضا في
+
+148
+00:12:52,320 --> 00:12:57,600
+حالة الـ Non-alcohol Stetohepatitis اللي اختصاره
+
+149
+00:12:57,600 --> 00:13:04,260
+NASH الـ Non-alcohol Stetohepatitis هذا مرضطبعاً
+
+150
+00:13:04,260 --> 00:13:10,660
+بيسموه مرض تشمع الكبد تشمع الكبد انه الدهون بتبدأ
+
+151
+00:13:10,660 --> 00:13:15,860
+تتراكم على ال liver طبعاً الفات بتبدأ تتراكم على
+
+152
+00:13:15,860 --> 00:13:21,110
+ال liverومش بد ضرورة يصيب الناس اللي بتناولوا كحول
+
+153
+00:13:21,110 --> 00:13:24,350
+يعني بيسمونا alcohol يعني اللي بينصابوا فيه كمان
+
+154
+00:13:24,350 --> 00:13:28,490
+ما بيشربوا كحول انه نحكي مثلا من الكحول هي عاملة
+
+155
+00:13:28,490 --> 00:13:34,350
+هذه المشكلة هدول الأشخاص المشكلة عندهم metabolic
+
+156
+00:13:34,350 --> 00:13:40,500
+syndrome يعني opacity نتيجة الزيادة في الوزننتيجة
+
+157
+00:13:40,500 --> 00:13:44,560
+ارتفاع السكر في الدم بميكانيزمات معينة، الضهون
+
+158
+00:13:44,560 --> 00:13:51,100
+عندهم تتراكم على الكبد، برضه هدول الأشخاصبيصير
+
+159
+00:13:51,100 --> 00:13:55,660
+عندهم Minor Innovation ارتفاع بسيط في الـ ALT
+
+160
+00:13:55,660 --> 00:14:00,280
+تقريبا من 50 لـ 100 International Unit per Liter
+
+161
+00:14:00,280 --> 00:14:04,560
+بيرتفع طبعا الـ Non-alcoholistetohepatitis لو
+
+162
+00:14:04,560 --> 00:14:09,460
+حبيته تعرفوا هذا المرض ممكن على جوجل تشوفه و
+
+163
+00:14:09,460 --> 00:14:17,400
+تبحثوا عنه تمامLevels of AST and ALT AST is
+
+164
+00:14:17,400 --> 00:14:21,960
+assessed along ALT الـ Monitoring Liver Damage يا
+
+165
+00:14:21,960 --> 00:14:28,000
+جماعة ما بينطلب كل فحص لحاله عادة الـ AST والـ ALT
+
+166
+00:14:28,000 --> 00:14:33,540
+اتنين بينطلبوا مع بعض عشان نشيط على وضع الكبد
+
+167
+00:14:33,540 --> 00:14:39,610
+ونشوف هل حدث liver damage or not تمام؟These two
+
+168
+00:14:39,610 --> 00:14:44,990
+values normally exist in an approximately واحد
+
+169
+00:14:44,990 --> 00:14:51,250
+لواحد ratio عند الإنسان الطبيعي الـ AST والـ ALT
+
+170
+00:14:51,250 --> 00:14:57,030
+التنين تقريبا في السيرم نفس التركيز فال ratio
+
+171
+00:14:57,030 --> 00:15:02,830
+لإلهم واحد لواحد يعني موجودين بالسيرم ب ratio واحد
+
+172
+00:15:02,830 --> 00:15:07,390
+لواحد نفس التركيز تقريبا هذا عند الإنسان الطبيعي،
+
+173
+00:15:07,390 --> 00:15:13,240
+تمام؟as a rough guide لكن في حالات مرضية ممكن
+
+174
+00:15:13,240 --> 00:15:19,860
+انزايم يزيد عن الانزايم الآخر مثلا الـ AST بيكون
+
+175
+00:15:19,860 --> 00:15:24,460
+أعلى من الـ ALT في حالة الـ Alcohol Hepatitis
+
+176
+00:15:24,460 --> 00:15:28,260
+التهاب الكبد نتيجة تناول الكحول حالات الـ
+
+177
+00:15:28,260 --> 00:15:33,040
+Cirrhosis تليفات الكبد حالات الـ Metastatic Cancer
+
+178
+00:15:33,040 --> 00:15:38,700
+of Liver حالات انتقال الكنسر بيكون الكنسر من مكان
+
+179
+00:15:39,230 --> 00:15:45,750
+وبيجي بنتقل على ال liver الـ non-pilary cirrhosis
+
+180
+00:15:45,750 --> 00:15:50,670
+تليفات بتخص الكبد ما بتخص القناة نفسها القناة
+
+181
+00:15:50,670 --> 00:15:58,060
+الصفراويةلكن الـ ALT بيكون أعلى من الـ AST في
+
+182
+00:15:58,060 --> 00:16:03,320
+حالات الـ Viral End Drug Hepatitis يعني التهاد
+
+183
+00:16:03,320 --> 00:16:10,040
+خلايا الكبد نتيجة فيروس أو نتيجة تناول أدوية أثرت
+
+184
+00:16:10,040 --> 00:16:15,210
+بسميتها على الكبدالـ Chronic Hepatitis C التهاب
+
+185
+00:16:15,210 --> 00:16:21,590
+الكبت نتيجة برضه فيروس وهذه حالة صارت لما بدخل
+
+186
+00:16:21,590 --> 00:16:25,690
+الفيروس وممكن تظلها الحالة chronic، مزمنة حالات
+
+187
+00:16:25,690 --> 00:16:29,590
+الـ Hepatic Obstruction انثداد في الـ Bile Reduct
+
+188
+00:16:29,590 --> 00:16:34,390
+في القناع الصفراوية لمابعد الكبت هذه حالات الـ ALT
+
+189
+00:16:34,390 --> 00:16:41,190
+بزيد فيها أكتر من الـ ASD تمام؟هل جيت؟ هنشوف
+
+190
+00:16:41,190 --> 00:16:47,290
+مجموعة من الفحوصات هذه الفحوصات أيضًا بتشيك هل في
+
+191
+00:16:47,290 --> 00:16:52,210
+عندنا كلستاثث عندنا حصاوي Stons سواء في الكبد نفسه
+
+192
+00:16:52,210 --> 00:16:56,490
+وبالتالي هيأثر على الخلايا تبعته أو في الـBiliary
+
+193
+00:16:56,490 --> 00:17:02,010
+duct في القناع السفراوية في Stons ولا لا أول فحص
+
+194
+00:17:02,010 --> 00:17:06,330
+هو الـALB الـAlkaline Phosphatase Enzyme
+
+195
+00:17:07,530 --> 00:17:12,090
+Phosphatases transfer a phosphate moiety from one
+
+196
+00:17:12,090 --> 00:17:16,430
+group to a second Forming an alcohol and a second
+
+197
+00:17:16,430 --> 00:17:20,330
+phosphate compound تعالوا نشوف التفاعل ال reaction
+
+198
+00:17:20,330 --> 00:17:26,020
+هنفهم الكلامهلجيت يا جماعة انزايم الـ ALB بيشتغل
+
+199
+00:17:26,020 --> 00:17:31,220
+at alkaline pH يعني بده medium media تكون هذه ال
+
+200
+00:17:31,220 --> 00:17:36,680
+media قاعدية بيئة قاعدية من تسعة لعشر ال pH لازم
+
+201
+00:17:36,680 --> 00:17:42,120
+يكون تمام الـ ALB ال substrate هذا الانزايم اللي
+
+202
+00:17:42,120 --> 00:17:44,980
+له substrate اللي له مادة بيشتغل عليها اسم ال
+
+203
+00:17:44,980 --> 00:17:50,940
+substrate فوسفو مونيستر فوسفو مونو إيسترهذا الـ
+
+204
+00:17:50,940 --> 00:17:55,760
+enzyme بيجعل هذه الـ substrate و بيكثرها محصلة
+
+205
+00:17:55,760 --> 00:18:01,180
+التكسير هيعطيني الكحول و هيعطيني فوسفات ايون لما
+
+206
+00:18:01,180 --> 00:18:06,180
+المادة تتفاعل مع الميّه إذا فوسفة monoester مع
+
+207
+00:18:06,180 --> 00:18:11,830
+الميّه في وجود ال ALB هيعطيني كحول و فوسفات ايونAt
+
+208
+00:18:11,830 --> 00:18:16,770
+alkaline pH The optimal reaction pH for ALP is
+
+209
+00:18:16,770 --> 00:18:22,450
+between 9 و10 عشان ال enzyme يشتغل بده pH تكون من
+
+210
+00:18:22,450 --> 00:18:27,210
+9 ل 10 and that is with the buffer and substrate
+
+211
+00:18:27,210 --> 00:18:32,590
+طبعا مش بس الفوسفة منيستر هي ال substrate لل
+
+212
+00:18:32,590 --> 00:18:36,840
+enzyme فيه substrate أخرى تمام؟هذا الـ enzyme
+
+213
+00:18:36,840 --> 00:18:40,920
+require مغنيسيوم as an activator عشان يشتغل بده
+
+214
+00:18:40,920 --> 00:18:44,380
+محفظ، بده co-factor هذا الـ enzyme عشان يشتغل بده
+
+215
+00:18:44,380 --> 00:18:49,240
+محفظ المحفظ تبعه هو المغنيسيوم، تمام؟
+
+216
+00:18:51,740 --> 00:18:58,640
+الـ Isoenzymes نظائر الـ ALB ALB exists as a
+
+217
+00:18:58,640 --> 00:19:03,820
+number of Isoenzymes الـ ALB فيه إلى عدد من
+
+218
+00:19:03,820 --> 00:19:11,080
+النظائر موجودين في organ مختلفة major are thus
+
+219
+00:19:11,080 --> 00:19:15,580
+found الـ ALB موجود في الـ liver في الـ bone في
+
+220
+00:19:15,580 --> 00:19:20,430
+الـ placenta وفي الـ intestine تمام؟إذا في عندي
+
+221
+00:19:20,430 --> 00:19:24,510
+ALB موجود في الكبت وموجود في العضام وموجود في الـ
+
+222
+00:19:24,510 --> 00:19:30,430
+placenta وموجود في الأمعاة هلجيت كيف لو بدنا نفرج
+
+223
+00:19:30,430 --> 00:19:37,310
+كل ALB عن الـ ALB الآخر أنا في عندي ALB موجود في
+
+224
+00:19:37,310 --> 00:19:39,510
+الكبت، في الـ bone، في الـ placenta، في الـ
+
+225
+00:19:39,510 --> 00:19:44,870
+intestine هذه كلها مظائر للإنزايمكلها تتشارك مع
+
+226
+00:19:44,870 --> 00:19:49,790
+بعضها في خصائص و بتختلف مع بعضها في خصائص كيف بدي
+
+227
+00:19:49,790 --> 00:19:55,190
+أفرج بينهم و أفصلهم بتقنية الـ Electrophoresis
+
+228
+00:19:55,190 --> 00:20:00,010
+تفصل الـ ALB الأربعة اللي جاية من الكبط و الـ bone
+
+229
+00:20:00,010 --> 00:20:06,340
+و الـ placenta و الـ intestineوبتحسب تركيز كل ALB
+
+230
+00:20:06,340 --> 00:20:09,880
+على حدة يعني الـ ALB اللي جاي من اللفر بتم حساب
+
+231
+00:20:09,880 --> 00:20:14,260
+تركيزه من البون، من الـ placenta، من الـ intestine
+
+232
+00:20:14,260 --> 00:20:20,380
+بواسطة الـ Electrophoresis بحكي للـ ALBهذا النظير
+
+233
+00:20:20,380 --> 00:20:24,980
+اللي بيكون في الكبد على الـ Electrophoresis على
+
+234
+00:20:24,980 --> 00:20:30,140
+الجل أو الـ cellulose acetate بيمشي بشكل أسرع لكن
+
+235
+00:20:30,140 --> 00:20:34,240
+الـ ALB اللي بيطلع من الـ intestine في الـ
+
+236
+00:20:34,240 --> 00:20:37,680
+Electrophoresis أثناء الفصل لما بيمشي بيكون قطة
+
+237
+00:20:37,680 --> 00:20:44,530
+واحد هذه من خصائصهم، تمام؟أو تقنية أخرى هي
+
+238
+00:20:44,530 --> 00:20:48,810
+immunochemical بيعتبروا أن الـ enzyme هذا النظير
+
+239
+00:20:48,810 --> 00:20:53,700
+الـ ALB Antigenالـ Enzyme عبارة عن الـ Antigen
+
+240
+00:20:53,700 --> 00:20:59,060
+بروح يجيبوا Antibody متخصص لهذا الـ Antigen فالـ
+
+241
+00:20:59,060 --> 00:21:02,620
+Antibody بربط بالـ Enzyme و بعطيني Complex
+
+242
+00:21:02,620 --> 00:21:06,540
+Antibody Antigen Reaction بحسب هذا الـ Complex
+
+243
+00:21:06,540 --> 00:21:14,040
+بطرق منعية عشان أشوف تركيز الـ Enzyme تمام؟ لكن يا
+
+244
+00:21:14,040 --> 00:21:21,160
+جماعة هنا بدنا نبّح على شغلالـ ALB موجود في الـ
+
+245
+00:21:21,160 --> 00:21:26,060
+serum تبع الإنسان بتركيز قليلة جدا زي و زي الـ ALT
+
+246
+00:21:26,060 --> 00:21:33,920
+و الـ ASTلكن في حال إجاني شخص فحصله الـ ALB اللي
+
+247
+00:21:33,920 --> 00:21:38,220
+في الـ Serum و لاجئته عالي كتير كتير كتير هذا
+
+248
+00:21:38,220 --> 00:21:44,000
+بيعطيك مؤشر على شو انه حدث اندي damage في ال organ
+
+249
+00:21:44,000 --> 00:21:49,080
+طيب أي organ بالظبط؟ هل حدث damage في ال liver ولا
+
+250
+00:21:49,080 --> 00:21:52,560
+في ال bone ولا في ال placenta ولا في ال intestine
+
+251
+00:21:52,560 --> 00:21:58,860
+ما بتقدر تعرفي من خلال الفحص تمام؟إذا فحص الـ ALP
+
+252
+00:21:58,860 --> 00:22:04,220
+لو كان الـ ALP عالي كتير في الدم بعطيكي مؤشر إن
+
+253
+00:22:04,220 --> 00:22:08,480
+هذا الشخص عنده tissue damage عنده تدمير في الخلايا
+
+254
+00:22:08,480 --> 00:22:12,960
+وفي أعضاء معينة طب إيش هذه ال organ اللي صار إليها
+
+255
+00:22:12,960 --> 00:22:16,560
+damage؟ هل الكبد اتدمر؟ ولا البون اتدمر؟ ولا
+
+256
+00:22:16,560 --> 00:22:19,700
+البلاسنتا؟ ولا ال intestine؟ ما دولة أربع مناطق
+
+257
+00:22:19,700 --> 00:22:26,430
+فيهم ALP مابنعرف، تمام؟لو بدى أعرف وين الدمج
+
+258
+00:22:26,430 --> 00:22:31,910
+بالظبط بتروحى تعملى الـ Electrophoresis عشان تشوف
+
+259
+00:22:31,910 --> 00:22:36,990
+الـ ALB اللى جاي من الكبد و الـ ALB اللى جاي من
+
+260
+00:22:36,990 --> 00:22:40,070
+البعض و الـ ALB اللى جاى من الـ placenta و الـ ALB
+
+261
+00:22:40,070 --> 00:22:44,410
+اللى جاى من الـ intestine مين أعلى واحد في التركيز
+
+262
+00:22:44,410 --> 00:22:49,920
+طبعا فى جهاز اسمه Densitometerبحد التركيز كل واحد
+
+263
+00:22:49,920 --> 00:22:54,180
+على حده فبتعرف اللي أعلى في التركيز معناه هذا
+
+264
+00:22:54,180 --> 00:22:58,700
+العضو هو اللي صار في الدمش، تمام؟ عشان هيك فحص ال
+
+265
+00:22:58,700 --> 00:23:04,780
+ALP مش متخصص للكبد برتفع في حالات مشاكل العضام،
+
+266
+00:23:04,780 --> 00:23:09,520
+مشاكل البلاسنتا، مشاكل الأمعة، تمام؟ هذه الشغله
+
+267
+00:23:09,520 --> 00:23:15,030
+كتير ضرورية نفهمهاالـ Clinical Significance بدنا
+
+268
+00:23:15,030 --> 00:23:20,650
+نحكي عن أهمية أنزايم الـ ALB أهمية هذا الفحص
+
+269
+00:23:20,650 --> 00:23:25,010
+alkaline phosphatase is an enzyme found in the
+
+270
+00:23:25,010 --> 00:23:29,440
+liver pan placenta intestine and kidneysالـ ALB
+
+271
+00:23:29,440 --> 00:23:33,800
+عبارة عن إنزايم موجود في الـ tissue كتيرة في الكبد
+
+272
+00:23:33,800 --> 00:23:36,320
+و في البان و في الـ placenta و الـ intestine و الـ
+
+273
+00:23:36,320 --> 00:23:40,680
+kidneys و لو قرأته مقالة هيحكيلكم إن الـ ALB موجود
+
+274
+00:23:40,680 --> 00:23:44,520
+في كل الـ organ في كل الـ tissue اللي موجودة في
+
+275
+00:23:44,520 --> 00:23:49,580
+الجسم فيها ALB تمام؟ تركيزه في الدم قليل جدا هذا
+
+276
+00:23:49,580 --> 00:23:55,410
+الوضع الطبيعي لكن مكانه أصلي جوات الخلاياA
+
+277
+00:23:55,410 --> 00:24:00,610
+primarily in the cells lining the biliary tract
+
+278
+00:24:00,610 --> 00:24:06,570
+يعني يا جماعة كمان الـ ALB موجود في الخلايا اللي
+
+279
+00:24:06,570 --> 00:24:11,230
+بتكون الـ biliary tract القناة السفراوية هالجدل دي
+
+280
+00:24:11,230 --> 00:24:16,690
+اكم تتخيلوا معي فوق في الكبداللي بيصل بين الكبد
+
+281
+00:24:16,690 --> 00:24:20,590
+والأمعاء اللي موجودة تحت الـIntestine قناة، القناة
+
+282
+00:24:20,590 --> 00:24:25,470
+الصفرية الـBiliary Duct إذن، في عندي كبد وتحتها في
+
+283
+00:24:25,470 --> 00:24:30,270
+قناة صفرية، Biliary Duct وتحت القناة الصفرية في
+
+284
+00:24:30,270 --> 00:24:34,990
+الأمعاء هلجيت هذه الـBiliary Duct القناة الصفرية
+
+285
+00:24:34,990 --> 00:24:40,030
+الخلايا اللي فيها هذه الخلايا أيضًا موجود فيها
+
+286
+00:24:40,030 --> 00:24:51,350
+الـALB، تمام؟أيضًا هذه الخلايا اللي بتكون القناة
+
+287
+00:24:51,350 --> 00:24:57,410
+الصفراوية لو اتكون في القناة stones حصاوي هذه
+
+288
+00:24:57,410 --> 00:25:03,010
+الحصاوية هتدمر الخلايا وبالتالي الخلايا هتبدأ تفرز
+
+289
+00:25:03,010 --> 00:25:10,530
+ALB إذا انتفضنا الـ ALB موجودبشكل أساسي في الخلايا
+
+290
+00:25:10,530 --> 00:25:17,010
+اللي بتكون القناع الصفراوية فلو اتكونت حصاوي في
+
+291
+00:25:17,010 --> 00:25:21,190
+القناع الصفراوية هتأثر على الخلايا الموجودة هناك
+
+292
+00:25:21,190 --> 00:25:27,210
+وبالتاليهتبدأ الخلايا تفرز ALP ويزيد تركيزه في
+
+293
+00:25:27,210 --> 00:25:31,850
+الدم عشان هيك حكينا إن الـ ALP يعني بنعتبره مؤشر
+
+294
+00:25:31,850 --> 00:25:38,170
+لوجود كوليستاسز لوجود حصاوي في القناة الصفرية إذن
+
+295
+00:25:38,170 --> 00:25:42,610
+كمان شغلة بدأ أحكيلكم إنه كمان لما بيصير عندي دمش
+
+296
+00:25:42,610 --> 00:25:47,310
+في خلايا الكبد يعني خلايا الكبد اضدمرت برضه الـ
+
+297
+00:25:47,310 --> 00:25:52,260
+ALP هيزيد في الدملأن الكبد برضه بفرز ALB تمام؟
+
+298
+00:25:52,260 --> 00:25:57,400
+وبالتالي هيطلع الـ ALB من الكبد على الدم ولكن بشكل
+
+299
+00:25:57,400 --> 00:26:02,720
+أكبر الـ ALB بيزيد كتير كتير كتير لما بتتكون حصاوي
+
+300
+00:26:02,720 --> 00:26:07,040
+في القناع الصفراوية لأن هذه الحصاوية اللي في
+
+301
+00:26:07,040 --> 00:26:11,700
+القناع هتأثر على الخلايا اللي في القناع وبالتالي
+
+302
+00:26:12,360 --> 00:26:18,700
+هتبدأ تفرز ALB ويزيد تركيزه بشكل أكبر، تمام؟ أيضًا
+
+303
+00:26:18,700 --> 00:26:24,860
+الـ ALB بيكون موجود في الـ Osteoplast الخلايا
+
+304
+00:26:24,860 --> 00:26:30,340
+البنائية للعدم، تمام؟ involved in the formation of
+
+305
+00:26:30,340 --> 00:26:34,310
+a new bone الجثة العضام لما تنبنيتحتاج لـ
+
+306
+00:26:34,310 --> 00:26:39,690
+Osteoplast خلايا بناء عشان تبنيها هذه الخلايا برضه
+
+307
+00:26:39,690 --> 00:26:47,190
+بتفرذ ALB جواها في ALB تمام؟ فالـ ALB is normally
+
+308
+00:26:47,190 --> 00:26:53,030
+executed from the liver in the bile برضه الـ ALB
+
+309
+00:26:53,030 --> 00:27:00,190
+يا جماعة بشكل طبيعي بيصيرله executionمن الكبد إلى
+
+310
+00:27:00,190 --> 00:27:08,790
+الـ Biliary Duct للقناة السفرية بشكل طبيعي زيادة
+
+311
+00:27:08,790 --> 00:27:16,370
+الـ ALP زيادة الـ ALP بنشوفه بشكل شائع عند الـ
+
+312
+00:27:16,370 --> 00:27:20,790
+Bonne Growth عند الـ Children الأطفالالأطفال،
+
+313
+00:27:20,790 --> 00:27:24,870
+الأطفال، مش بنحكي، بيكونوا في مرحلة بناء للعضم
+
+314
+00:27:24,870 --> 00:27:29,390
+تبعهم البناء، يعني خلايا الـ Osteoplast بدها تبدأ
+
+315
+00:27:29,390 --> 00:27:34,070
+تشتغل، الخلايا البناءة الخلايا هذه بتبدأ تفرذ
+
+316
+00:27:34,070 --> 00:27:39,390
+أثناء بناء الإظام، بتبدأ تفرذ الـ ALB لأنه فيها
+
+317
+00:27:39,390 --> 00:27:44,660
+ALB، تمام؟وبالتالي عند الأطفال لو فحصنا ALP حالة
+
+318
+00:27:44,660 --> 00:27:49,260
+جيه عالى عندهم مش عالى لإن عندهم حالات مرضية عالى
+
+319
+00:27:49,260 --> 00:27:53,240
+لإن هم في مرحلة بناء ال osteoblast الخلايا البناءة
+
+320
+00:27:53,240 --> 00:27:57,020
+تحت العضم تبدأ تشتغل عندهم وبالتالي أثناء شغلها
+
+321
+00:27:57,020 --> 00:28:01,520
+بيصير في release لل ALP بيطلع ال ALP على الدم
+
+322
+00:28:01,520 --> 00:28:07,100
+ويرتفع تركيزهأيضًا الـ ALP بيرتفع في حالات liver
+
+323
+00:28:07,100 --> 00:28:11,180
+disease مشاكل الكبط لأنه أصلا هو موجود في الكبط صح
+
+324
+00:28:11,180 --> 00:28:15,140
+ولا لأ؟ فأي دمش في الكبط هيطلع على الدم ويزيد
+
+325
+00:28:15,140 --> 00:28:19,460
+تركيزه برضه ال ALP بيزيد في حالات ال binary
+
+326
+00:28:19,460 --> 00:28:25,120
+obstruction انسداد في القناة الصفراوية نتيجة تكوين
+
+327
+00:28:25,120 --> 00:28:29,610
+stones حكينا القناة الصفراويةلو اتكونت فيها حصاوي
+
+328
+00:28:29,610 --> 00:28:35,870
+الخلايا اللي كونت القناع أصلا فيها ALB وبالتالي
+
+329
+00:28:35,870 --> 00:28:40,830
+وجود الحصاوي في هذه الخلايا هيدمرها ويخليها تفرز
+
+330
+00:28:40,830 --> 00:28:47,640
+ALB منها للدم، تمام؟أذن تلت حالات بيرتفع فيهم الـ
+
+331
+00:28:47,640 --> 00:28:52,700
+ALP تكوين الـ stones في القناة الصفرية وجود مشكلة
+
+332
+00:28:52,700 --> 00:28:56,820
+فيه الكبت حالات الـ growth إنه مو عند الأطفال بشكل
+
+333
+00:28:56,820 --> 00:29:02,780
+طبيعيSerum ALB Activity Primarily Reflects
+
+334
+00:29:02,780 --> 00:29:06,740
+الـChanges في الـBone وLiver Function طبعا تركيز
+
+335
+00:29:06,740 --> 00:29:12,400
+الـ ALB نشاط الـ ALB بيعكس مدى التغيرات اللي بتسير
+
+336
+00:29:12,400 --> 00:29:17,340
+في الكبط و البون أكيد لأنه أصلا هو موجود في الكبط
+
+337
+00:29:17,340 --> 00:29:22,100
+وموجود في البون فأي مشكلة فيهم في ال liver أو في
+
+338
+00:29:22,100 --> 00:29:27,100
+البون هيأثر على تركيز ال ALBبالتالي، حتى لو كان
+
+339
+00:29:27,100 --> 00:29:31,880
+هناك عملية ALP أعلى ممكن تجدها في أعضاء أخرى برضه
+
+340
+00:29:31,880 --> 00:29:40,270
+الـ ALP موجودة في أعضاء أخرى وبتركيز عاليةعلى
+
+341
+00:29:40,270 --> 00:29:44,110
+الرغم من أن الـ ALB تفاجنا موجود في كل الـ tissue
+
+342
+00:29:44,110 --> 00:29:49,030
+في كل الـ organ لكن فعلياً الـ activity تبعت الـ
+
+343
+00:29:49,030 --> 00:29:54,530
+ALB أكتر إشي يعني تتأثر في مشاكل ال liver و ال
+
+344
+00:29:54,530 --> 00:29:57,910
+bone هم اللي بيحددوا تركيز ال ALB ال liver و ال
+
+345
+00:29:57,910 --> 00:30:02,350
+bone على الرغم من أنه موجود في organ أخرى بتركيز
+
+346
+00:30:02,350 --> 00:30:08,780
+عالية تمام؟Specimen collection جمع العينة a blood
+
+347
+00:30:08,780 --> 00:30:12,720
+should be drawn after a fast of at least 8 hours
+
+348
+00:30:12,720 --> 00:30:18,140
+يعني لما بنعمل فحص ال ALP يفضل يفضل أن نصوم 8
+
+349
+00:30:18,140 --> 00:30:22,980
+ساعات قبل إجراء الفحص العينة سيرم أو بلازمة نوع ال
+
+350
+00:30:22,980 --> 00:30:29,480
+anticoagulant المسموح فقط فيه هو الهيبرين slight
+
+351
+00:30:29,480 --> 00:30:35,440
+hemolysis isTolerable يعني لما بيكون العينة انت
+
+352
+00:30:35,440 --> 00:30:38,220
+شايفة فيه Hemolysis شايفة انه فيه تكسير في
+
+353
+00:30:38,220 --> 00:30:42,060
+الاربيسيز ولكن slight بسيط أو خفيف بقبلها
+
+354
+00:30:42,060 --> 00:30:46,200
+tolerable تمام but gross Hemolysis لو جاتني عينة
+
+355
+00:30:46,200 --> 00:30:52,560
+الاربيسيز أغلبها مكسر اجرس Hemolysis اجرس يعني ال
+
+356
+00:30:52,560 --> 00:30:56,360
+Hemolysis كتير كتير شديد هذه should be avoided
+
+357
+00:30:56,360 --> 00:31:03,190
+يعني بأرفض العينة تماماإذن بفهم إن الـ ALB أيضًا
+
+358
+00:31:03,190 --> 00:31:07,190
+موجود جوّات الـ RBCs متفاجنة، موجود في كل أنسجة
+
+359
+00:31:07,190 --> 00:31:10,590
+الجسم تقريبًا، هذا الـ enzyme موجود في كل أنسجة
+
+360
+00:31:10,590 --> 00:31:15,570
+الجسم، حتى الـ RBCs، تمام؟ الـ point الرابع من
+
+361
+00:31:15,570 --> 00:31:20,190
+الشريحة ما بدنا إياهانجي للـ point الخامسة it is
+
+362
+00:31:20,190 --> 00:31:24,630
+best to analyze ال ALB specimens the same day they
+
+363
+00:31:24,630 --> 00:31:29,290
+are drawn يفضل ما انخزن العينة اللي بديها يعني ما
+
+364
+00:31:29,290 --> 00:31:32,510
+أخزن ال serum أو البلازمة في التلاجة أو بالفريزر
+
+365
+00:31:32,510 --> 00:31:36,310
+عشان أشتغل ال ALB وفضل في اليوم اللي بجمع فيه
+
+366
+00:31:36,310 --> 00:31:41,830
+العينة أفحص ال enzyme على طول، تمام؟الـ ALB is
+
+367
+00:31:41,830 --> 00:31:46,650
+inhibited bymetal-complexing anticoagulant إيش
+
+368
+00:31:46,650 --> 00:31:51,730
+يعني؟ يعني الإديتا والأجزالات والسترات هذه الـ
+
+369
+00:31:51,730 --> 00:31:56,670
+anticoagulant ممنوع أسحب فيها تمام؟ إديتا،
+
+370
+00:31:56,670 --> 00:32:01,410
+أجزالات، سترات ممنوع أسحب فيهم ليش؟ لأن كل هذه الـ
+
+371
+00:32:01,410 --> 00:32:07,250
+anticoagulant بتشتغل كـ chelating agent بتشتغل
+
+372
+00:32:07,750 --> 00:32:12,830
+فتسحب المغنيسيوم تمام؟ المغنيسيوم اتفاجنا هذا الـ
+
+373
+00:32:12,830 --> 00:32:18,930
+Co-Factor لـ ALB هو المسئول عن نشاط إنزايم الـ ALB
+
+374
+00:32:18,930 --> 00:32:23,690
+فلو انسحب المغنيسيوم لو أنا جماعة عينت الدم
+
+375
+00:32:23,690 --> 00:32:28,010
+بإيديتا أو أجزالات أو ستريات هذه الـ Anticoagulant
+
+376
+00:32:28,010 --> 00:32:31,920
+تشتغل Calculating Agent تسحب المغنيسيوموبالتالي
+
+377
+00:32:31,920 --> 00:32:35,120
+الـ ALB مش هيشتغل الـ enzyme مش هيشتغل على الـ
+
+378
+00:32:35,120 --> 00:32:39,440
+substrate تبعته لإن الـ cofactor تم سحبه عشان هيك
+
+379
+00:32:39,440 --> 00:32:44,180
+ممنوعة هذه الـ anticoagulant لإنه بتعمل inhibit لل
+
+380
+00:32:44,180 --> 00:32:50,080
+enzyme بتثبت ال ALB كيف بتثبته من خلال إنها بتسحب
+
+381
+00:32:50,080 --> 00:32:55,420
+المغنيسيوم عشان هيك ممنوع الجمع بهذه الـ
+
+382
+00:32:55,420 --> 00:33:01,500
+anticoagulantassay for enzyme activity بدنا نشوف
+
+383
+00:33:01,500 --> 00:33:06,740
+الطرق المستخدمة لقياس نشاط ال ALP almost all
+
+384
+00:33:06,740 --> 00:33:11,520
+assays for ALP employ P-Nitrophenyl Phosphate as
+
+385
+00:33:11,520 --> 00:33:16,660
+the substrate تقريبا كل الطرق وكل الكتاتالـ
+
+386
+00:33:16,660 --> 00:33:20,820
+Reagent بيحتوي على الـ Substrate إيش هذه الـ
+
+387
+00:33:20,820 --> 00:33:25,840
+Substrate؟ اسمها الـ B-Nitro Phenyl Phosphate هذه
+
+388
+00:33:25,840 --> 00:33:32,030
+الـ Substrate تبع إنزايم الـ ALB تمام؟هلجيت،
+
+389
+00:33:32,030 --> 00:33:35,330
+انتبهوا تحت في الـReaction بدنا نتخيل كيف
+
+390
+00:33:35,330 --> 00:33:40,570
+الـReaction حيصير الـALB هذا الـEnzyme موجود في
+
+391
+00:33:40,570 --> 00:33:43,650
+الـPatient Serum أو الـPatient Plasma وأنا بدي
+
+392
+00:33:43,650 --> 00:33:48,190
+أقيس الـActivity تبعتها الـReagent بيكون جاي من
+
+393
+00:33:48,190 --> 00:33:52,830
+الـCAT الـReagent بيكون في الـCAT جاي من شركة
+
+394
+00:33:52,830 --> 00:33:57,610
+معينة الـReagent يحتوي على Substrate اسمها الـB
+
+395
+00:33:57,610 --> 00:34:02,910
+-Nitrophenyl Phosphateوهذا الـ Substrate colorless
+
+396
+00:34:02,910 --> 00:34:09,030
+ما إلها أي لون تمام؟ والـ pH تبع الـ reagent هي
+
+397
+00:34:09,030 --> 00:34:12,810
+alkaline media لأن اتفجنا الـ ALP بيشتغل على
+
+398
+00:34:12,810 --> 00:34:18,150
+alkaline media عشرة point اتنين الـ pH هل جيت لما
+
+399
+00:34:18,150 --> 00:34:21,990
+تخلط الـ reagent ادريه وتحطيه على ال serum تبع ال
+
+400
+00:34:21,990 --> 00:34:26,640
+patient؟الـAlB الموجود في السيرام هيكسّر
+
+401
+00:34:26,640 --> 00:34:30,240
+الـsubstrate الموجودة في الـreagent اللي هي الـB
+
+402
+00:34:30,240 --> 00:34:37,080
+-Nitrophenyl Phosphate محصلة التكسير هينتج عندنا
+
+403
+00:34:37,080 --> 00:34:44,400
+مُركّب اسمه الـB-Nitrophenol-Phosphate-Ion الـB
+
+404
+00:34:44,400 --> 00:34:50,760
+-Nitrophenol هذه مادة إملونة، تمام؟هذه المادة
+
+405
+00:34:50,760 --> 00:34:57,080
+بيصيرلها انتصاص على 405 نانومتر بتم قراءتها على
+
+406
+00:34:57,080 --> 00:35:01,810
+الـ Spectrophotometerواللون اللي بينتج محصلة
+
+407
+00:35:01,810 --> 00:35:06,470
+التفاعل هو لون أصفر يعني بدنا نفهم أن طريقة الشغل
+
+408
+00:35:06,470 --> 00:35:11,810
+عادي جدا زي كأنه بفحص فحص سكر أو بروتين أو ألبومان
+
+409
+00:35:11,810 --> 00:35:16,350
+أو دهون colorometric reaction مش زي الـ ASC و الـ
+
+410
+00:35:16,350 --> 00:35:20,770
+ALT الـ ASC و الـ ALT اللي هم procedure معينة الـ
+
+411
+00:35:20,770 --> 00:35:26,950
+ALP لأ colorometric سهل جدا طريقة التفاعلالـ ALB
+
+412
+00:35:26,950 --> 00:35:30,850
+موجود في الـ Serum لما بنحط عليه الـ Reagent الـ
+
+413
+00:35:30,850 --> 00:35:35,150
+Reagent بيحتوي على مادة الـ B-Nitrophenylfosfate
+
+414
+00:35:35,150 --> 00:35:39,310
+هذه مادة غير ملونة لما بيشتغل عليها الـ enzyme
+
+415
+00:35:39,310 --> 00:35:45,610
+ويكسرهامحصلة التفاعل إعطاء مادة ملونة اللي هي الـB
+
+416
+00:35:45,610 --> 00:35:50,370
+-Nitrophenol لونها أسفر إذا لما بتحط السيرام على
+
+417
+00:35:50,370 --> 00:35:55,350
+الـReagent تحصلت الـReaction لون شدة اللون تتناسب
+
+418
+00:35:55,350 --> 00:36:00,250
+تناسب ترضي مع الـActivity تبع الإنزايم شدة اللون
+
+419
+00:36:00,250 --> 00:36:05,330
+الناتجة تتناسب تناسب ترضي مع الـActivity تبع
+
+420
+00:36:05,330 --> 00:36:09,930
+الإنزايم واضح؟ إذاً Calorimetric reaction عادي
+
+421
+00:36:09,930 --> 00:36:15,670
+جداًالـ Normal Range للـ ALP موجود في السيرم
+
+422
+00:36:15,670 --> 00:36:21,630
+تقريبا من 40 ل125 International Unit per Liter
+
+423
+00:36:21,630 --> 00:36:27,930
+تركيزه في الدمالإنزايم التاني الـ Gamma Glutamyl
+
+424
+00:36:27,930 --> 00:36:32,950
+Transferase أو ما يسمى بالـ GGT Gamma Glutamyl
+
+425
+00:36:32,950 --> 00:36:37,150
+Transferase أيضًا هذا الإنزايم الآخر اللي مع الـ
+
+426
+00:36:37,150 --> 00:36:42,930
+ALB التنين بيشيكوا هل فيه كوليستاسز موجودة في الـ
+
+427
+00:36:42,930 --> 00:36:46,430
+Biliary Tract ولا لأ، هل موجود حصاوي في القناة
+
+428
+00:36:46,430 --> 00:36:50,400
+الصفراوية ولا لأهذا الـ enzyme إيش ال reaction
+
+429
+00:36:50,400 --> 00:36:56,060
+تبعه؟ مش مطلوب نحفظه بس بدنا نحكيه Transfers الـ
+
+430
+00:36:56,060 --> 00:37:00,340
+Gamma Glutamyl Residue from Gamma Glutamyl Peptide
+
+431
+00:37:00,340 --> 00:37:04,940
+usually Glutathione to Amino Acid H2O and other
+
+432
+00:37:04,940 --> 00:37:09,840
+small peptides Glutathione serves as the Gamma
+
+433
+00:37:09,840 --> 00:37:15,080
+Glutamyl donor إيه جزء ده؟ شوف الصندوق الأزرق هذا
+
+434
+00:37:15,080 --> 00:37:19,800
+الـ Glutathione عبارة عن حمض أمينةالـ «Gamma
+
+435
+00:37:19,800 --> 00:37:22,940
+Glutamyl Transferase» هذا الـ إنزايم إيش بيعمل؟
+
+436
+00:37:22,940 --> 00:37:27,920
+بنجل الـ «Gamma Glutamyl Residue» من الـ
+
+437
+00:37:27,920 --> 00:37:33,320
+«Glutathione» وبيوديها على أمينو أسد آخر الأمينو
+
+438
+00:37:33,320 --> 00:37:37,100
+أسد آخر اللي هنا الأخر اللي هنا هو الـ cysteine
+
+439
+00:37:37,100 --> 00:37:42,420
+محصلة التفاعل لـ «Glutathione» هيتحول لـ «Glutamyl
+
+440
+00:37:42,420 --> 00:37:49,090
+Peptide»ويتكون عندي مركب اسمه الـ cysteine glycine
+
+441
+00:37:50,630 --> 00:37:55,550
+الوظيفة الأساسية له بنجل مجموعة الـ Gamma Glutamyl
+
+442
+00:37:55,550 --> 00:38:01,430
+من الـ Glutathione لأمينو أسد آخر يعني بيشتغل كـ
+
+443
+00:38:01,430 --> 00:38:07,110
+donor كمعطي لـ Gamma Glutamyl تمام؟ الـ
+
+444
+00:38:07,110 --> 00:38:12,190
+Glutathione بيشتغل كـ donor كمعطي لـ group إيش هو
+
+445
+00:38:12,190 --> 00:38:16,820
+الـ group؟ هو الـ Gamma Glutamylالـ GGT بيحكيلك
+
+446
+00:38:16,820 --> 00:38:20,880
+موجود بتركيز عالي جداً في الـ liver is a high
+
+447
+00:38:20,880 --> 00:38:24,600
+concentration in liver tissue موجود بتركيز عالي
+
+448
+00:38:24,600 --> 00:38:28,760
+جداً في الكبد أيضاً موجود في الـ kidney وموجود في
+
+449
+00:38:28,760 --> 00:38:33,260
+الـ pancreas وضيفوا عليها موجود أيضاً في الخلايا
+
+450
+00:38:33,260 --> 00:38:39,880
+اللي كونت ال bilary tract القناع الصفراوية تمام؟
+
+451
+00:38:39,880 --> 00:38:46,680
+وموجود في الدم بالوضع الطبيعي بتركيز قليلالـ
+
+452
+00:38:46,680 --> 00:38:50,520
+Diagnostic Significance أهمية فحص الـ GGT
+
+453
+00:38:50,520 --> 00:38:54,880
+Increased plasma GGT is associated with
+
+454
+00:38:54,880 --> 00:38:59,980
+hepatopilary disease يعني الـ GGT يا جماعة بيرتفع
+
+455
+00:38:59,980 --> 00:39:06,260
+لما بيصير عنده damage فيه أوالـ Stones حصاوي في
+
+456
+00:39:06,260 --> 00:39:10,100
+الـ Biliary Tract في القناة الصفرية وبالتالي
+
+457
+00:39:10,100 --> 00:39:14,300
+الحصاوي هتأثر على الخلايا الموجودة في هذه المنطقة
+
+458
+00:39:14,300 --> 00:39:20,020
+هذه الخلايا هتبدأ تفرز ash تفرز الـ GGT للبلازما،
+
+459
+00:39:20,020 --> 00:39:26,160
+تمام؟Highest seen in the bilary obstruction في
+
+460
+00:39:26,160 --> 00:39:31,460
+حالات الانتداد في القناع الصفراوية بسبب تكوين
+
+461
+00:39:31,460 --> 00:39:35,680
+Estones بيكون يعني تركيزه عالي كتير كتير برضه في
+
+462
+00:39:35,680 --> 00:39:39,380
+حالات الـ Alcohol cirrhosis تلايه في الكبد اللي
+
+463
+00:39:39,380 --> 00:39:44,020
+سببه تناول الكحول برضه بيرتفع الـ GGT في البلازمة
+
+464
+00:39:44,840 --> 00:39:50,500
+هلجيت فحص الـ GGT used with ALB يعني بينعملوا
+
+465
+00:39:50,500 --> 00:39:54,760
+التنين مع بعض to differentiate between liver and
+
+466
+00:39:54,760 --> 00:39:59,420
+bone disease عشان نميز هل المشكلة في الكبد ولا
+
+467
+00:39:59,420 --> 00:40:02,580
+المشكلة بالعظام خلّيني أركز على هذا اللقطة عشان
+
+468
+00:40:02,580 --> 00:40:07,660
+كتير مهمة حكينا إن الـ ALB موجود في الكبد وموجود
+
+469
+00:40:07,660 --> 00:40:13,390
+في العظاملكن الـ GGT موجود في الكبت بس مش موجود في
+
+470
+00:40:13,390 --> 00:40:17,570
+العظام فانت لما بتعمل الاتنين مع بعض تخيل إيجاني
+
+471
+00:40:17,570 --> 00:40:22,530
+مريض اعملتله ALB و GGT الاتنين مع بعض وطلع الاتنين
+
+472
+00:40:22,530 --> 00:40:28,250
+عليين كتير معناه أكيد في عندي مشكلة في الكبت مشكلة
+
+473
+00:40:28,250 --> 00:40:31,430
+في القدرات السفرية فيها حصاوي لما يكونوا الاتنين
+
+474
+00:40:31,430 --> 00:40:36,190
+عليين تمام؟ لكن إيجاني مريض تاني اعملتله الاتنين
+
+475
+00:40:36,190 --> 00:40:41,940
+مع بعض ال ALB و ال GGTطلع الـ ALB عنده عالي بس الـ
+
+476
+00:40:41,940 --> 00:40:48,820
+GGT normal إذاً هذا بيأكد عنده إن المشكلة عنده في
+
+477
+00:40:48,820 --> 00:40:53,040
+البان مشكلة في العظام الـ GGT عنده طلعة طبيعية
+
+478
+00:40:53,040 --> 00:40:57,960
+يعني القناة السفرية عندهم طبيعية والكبد عندهم
+
+479
+00:40:57,960 --> 00:41:03,060
+طبيعي إذا الـ ALB ارتفع لحاله معناه دا indication
+
+480
+00:41:03,060 --> 00:41:07,230
+إن المشكلة في البانلأن هو لحاله موجود في الـ bone
+
+481
+00:41:07,230 --> 00:41:12,550
+ما .. يعني ماهاش الـ GGT تمام؟ إذا لو عملت الفحصين
+
+482
+00:41:12,550 --> 00:41:16,690
+مع بعض والتانين طلعوا عالين إذا أكيد المشكلة في
+
+483
+00:41:16,690 --> 00:41:20,890
+الكبد وفي القناة الصفرية لو عملت الفحصين مع بعض
+
+484
+00:41:20,890 --> 00:41:26,630
+والـ ALB كان عالي والـ GGT كان طبيعي إذا أكيد
+
+485
+00:41:26,630 --> 00:41:30,490
+المشكلة بتكون في الـ bone في العظم تمام؟
+
+486
+00:41:32,760 --> 00:41:35,900
+الـ «Say for enzyme activity» بدنا نشوف الطرق
+
+487
+00:41:35,900 --> 00:41:39,940
+المستخدمة لقياس الـ enzyme كمان يا جماعة كتاتنا
+
+488
+00:41:39,940 --> 00:41:46,440
+اللي بتفحص الـ GGT برضه colorimetric reaction زي و
+
+489
+00:41:46,440 --> 00:41:50,100
+زي فحص الـ ALB بالظبط عشان هيك لما نرجع الجامعة
+
+490
+00:41:50,100 --> 00:41:54,980
+هنشتغل واحد منهمهنشتغل يا ALP يا GGT، بس اللي
+
+491
+00:41:54,980 --> 00:41:59,280
+متوفر عندنا في الجامعة الـ ALP، تمام؟ بس هذا ما
+
+492
+00:41:59,280 --> 00:42:02,400
+بيمنع أن نشوف قليلة التفاعل كيف قليلة التفاعل،
+
+493
+00:42:02,400 --> 00:42:06,200
+انتبهوا على الصندوق الأزرق هلجت الـ Serum تبع ال
+
+494
+00:42:06,200 --> 00:42:09,940
+patient بيكون فيه الـ GGT، بيكون فيه الـ enzyme،
+
+495
+00:42:09,940 --> 00:42:14,280
+تمام؟ و أنا بدي أفحص ال activity تبعتهاهل جيت الـ
+
+496
+00:42:14,280 --> 00:42:19,440
+reaction بيكون فيه الـ substrate اللي هيكسرها الـ
+
+497
+00:42:19,440 --> 00:42:25,200
+enzyme الـ substrate هي الـ L-Gamma-Glutamyl-B
+
+498
+00:42:25,200 --> 00:42:32,640
+-Nitro-Analyte زائد لـGlycyl-Glycineهذه كلها الـ
+
+499
+00:42:32,640 --> 00:42:37,140
+substrate موجودة في الـ reagent هيشتغل عليها الـ
+
+500
+00:42:37,140 --> 00:42:41,680
+enzyme اللي موجود في الـ serum ومحصلة التفاعل
+
+501
+00:42:41,680 --> 00:42:48,280
+هيعطيني مادة اسمها الـ B-Nitroaniline و الـ Gamma
+
+502
+00:42:48,280 --> 00:42:55,350
+Glutamyl Glycylglycineإذا محصلة التفاعل اعطاء مادة
+
+503
+00:42:55,350 --> 00:43:01,470
+ملونة الـ B-Nitroaniline وشدة اللون اللي اتكونها
+
+504
+00:43:01,470 --> 00:43:06,790
+نتيجة محصلة التفاعل هتتناسب تناسب ترضي مع نشاط الـ
+
+505
+00:43:06,790 --> 00:43:12,030
+enzyme في العينة ومادة الـ B-Nitroaniline هنقرأها
+
+506
+00:43:12,030 --> 00:43:18,020
+على wavelength 405 نانومترالـ Reference Range عند
+
+507
+00:43:18,020 --> 00:43:23,120
+المال من 6 لـ 45 International Unit Per Liter عند
+
+508
+00:43:23,120 --> 00:43:28,260
+الفمال من 5 ل 30 International Unit Per Liter إذا
+
+509
+00:43:28,260 --> 00:43:31,540
+المادة التفاعل إن السيران موجود في الإنزاين
+
+510
+00:43:31,540 --> 00:43:35,640
+والـreagent فيه الـsubstrateلما بحطهم على بعض الـ
+
+511
+00:43:35,640 --> 00:43:39,620
+enzyme هيكسّر ال substrate محصلة التفاعل مادة
+
+512
+00:43:39,620 --> 00:43:43,940
+ملونة احنا بنجيس هذه المادة على wavelength معينة
+
+513
+00:43:43,940 --> 00:43:48,160
+وشدة اللون هتتناسب تناسب تردي مع ال activity تبعت
+
+514
+00:43:48,160 --> 00:43:54,240
+ال enzyme وبهيك بنكون خلصنا chapter liver function
+
+515
+00:43:54,240 --> 00:43:55,940
+test ويعطيكم ألف عافية
+
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/OEKZUS3N-iI_raw.json b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/OEKZUS3N-iI_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..4014ce869350d47757cb65a3faf0bb29c1c09a4d
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/OEKZUS3N-iI_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 1541, "start": 0.77, "end": 15.41, "text": "هنحكي هنا عن الفحص التاني اللي بيشيك على الـ Hepatocellular injury هل خلايا الكبد فيها damage ولا لأ الإنزايم الآخر الـALT Alanine Aminotransferase", "tokens": [3224, 1863, 5016, 4117, 1829, 34105, 18871, 27188, 5016, 9381, 16712, 7649, 1829, 13672, 1829, 4724, 1829, 8592, 1829, 4117, 15844, 2423, 39184, 30578, 2513, 4164, 1040, 10454, 8032, 1211, 16490, 15040, 25528, 33251, 44510, 8978, 11296, 4344, 49429, 5296, 10721, 33688, 1863, 11622, 995, 32640, 6024, 95, 34740, 2423, 39184, 3427, 51, 16442, 533, 2012, 259, 310, 25392, 612, 651], "avg_logprob": -0.1842237869578023, "compression_ratio": 1.2790697674418605, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 0.77, "end": 1.45, "word": "هنحكي", "probability": 0.88798828125}, {"start": 1.45, "end": 1.73, "word": " هنا", "probability": 0.9814453125}, {"start": 1.73, "end": 2.21, "word": " عن", "probability": 0.99169921875}, {"start": 2.21, "end": 2.77, "word": " الفحص", "probability": 0.9085286458333334}, {"start": 2.77, "end": 3.41, "word": " التاني", "probability": 0.9685872395833334}, {"start": 3.41, "end": 3.85, "word": " اللي", "probability": 0.903564453125}, {"start": 3.85, "end": 4.37, "word": " بيشيك", "probability": 0.949609375}, {"start": 4.37, "end": 4.59, "word": " على", "probability": 0.89453125}, {"start": 4.59, "end": 4.75, "word": " الـ", "probability": 0.92724609375}, {"start": 4.75, "end": 5.69, "word": " Hepatocellular", "probability": 0.7664794921875}, {"start": 5.69, "end": 6.29, "word": " injury", "probability": 0.70947265625}, {"start": 6.29, "end": 6.87, "word": " هل", "probability": 0.82421875}, {"start": 6.87, "end": 7.31, "word": " خلايا", "probability": 0.8834635416666666}, {"start": 7.31, "end": 7.77, "word": " الكبد", "probability": 0.83056640625}, {"start": 7.77, "end": 8.27, "word": " فيها", "probability": 0.98583984375}, {"start": 8.27, "end": 8.67, "word": " damage", "probability": 0.74853515625}, {"start": 8.67, "end": 9.05, "word": " ولا", "probability": 0.7705078125}, {"start": 9.05, "end": 9.45, "word": " لأ", "probability": 0.97509765625}, {"start": 9.45, "end": 10.41, "word": " الإنزايم", "probability": 0.72666015625}, {"start": 10.41, "end": 11.01, "word": " الآخر", "probability": 0.91650390625}, {"start": 11.01, "end": 12.57, "word": " الـALT", "probability": 0.7247314453125}, {"start": 12.57, "end": 13.53, "word": " Alanine", "probability": 0.61767578125}, {"start": 13.53, "end": 15.41, "word": " Aminotransferase", "probability": 0.91796875}], "temperature": 1.0}, {"id": 2, "seek": 3211, "start": 15.69, "end": 32.11, "text": "a transferase with enzymatic activity similar to AST شغلوا يا جماعة نفس شغل الـ AST إيه شغلهم؟ ينجلق أمين جروب مجموعة أمين من مكان لمكان آخر، تمام؟", "tokens": [64, 5003, 651, 365, 16272, 25915, 5191, 2531, 281, 316, 6840, 13412, 17082, 1211, 14407, 35186, 10874, 15042, 27884, 8717, 36178, 13412, 17082, 1211, 2423, 39184, 316, 6840, 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"probability": 0.7418212890625}, {"start": 20.61, "end": 21.33, "word": " شغلوا", "probability": 0.718505859375}, {"start": 21.33, "end": 21.43, "word": " يا", "probability": 0.93798828125}, {"start": 21.43, "end": 22.01, "word": " جماعة", "probability": 0.99267578125}, {"start": 22.01, "end": 22.55, "word": " نفس", "probability": 0.957763671875}, {"start": 22.55, "end": 23.07, "word": " شغل", "probability": 0.9563802083333334}, {"start": 23.07, "end": 23.41, "word": " الـ", "probability": 0.786376953125}, {"start": 23.41, "end": 23.95, "word": " AST", "probability": 0.821044921875}, {"start": 23.95, "end": 24.37, "word": " إيه", "probability": 0.744873046875}, {"start": 24.37, "end": 25.27, "word": " شغلهم؟", "probability": 0.8689453125}, {"start": 25.27, "end": 26.01, "word": " ينجلق", "probability": 0.76328125}, {"start": 26.01, "end": 26.49, "word": " أمين", "probability": 0.8040364583333334}, {"start": 26.49, "end": 27.05, "word": " جروب", "probability": 0.80029296875}, {"start": 27.05, "end": 27.95, "word": " مجموعة", "probability": 0.90439453125}, {"start": 27.95, "end": 28.55, "word": " أمين", "probability": 0.9752604166666666}, {"start": 28.55, "end": 29.05, "word": " من", "probability": 0.974609375}, {"start": 29.05, "end": 29.65, "word": " مكان", "probability": 0.993408203125}, {"start": 29.65, "end": 30.61, "word": " لمكان", "probability": 0.94091796875}, {"start": 30.61, "end": 31.57, "word": " آخر،", "probability": 0.7579752604166666}, {"start": 31.57, "end": 32.11, "word": " تمام؟", "probability": 0.9840494791666666}], "temperature": 1.0}, {"id": 3, "seek": 5752, "start": 32.9, "end": 57.52, "text": "Converts هذا الـ ALT يحول الألانين والألفا كيتو إجلوتارات إلى مادة البيروفات والجلوتامات زي ما انتوا شايفين هي الـ Amino Acid الحمض الأميني الألانين مع الألفا كيتو إجلوتارات في وجود الـ ALT إنزايم إيش بيعمل؟ بنزع الـ Amino Group", "tokens": [9838, 36999, 23758, 2423, 39184, 7056, 51, 7251, 5016, 12610, 16247, 1211, 7649, 9957, 16070, 10721, 46538, 995, 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{"start": 44.48, "end": 44.96, "word": " شايفين", "probability": 0.9832763671875}, {"start": 44.96, "end": 45.48, "word": " هي", "probability": 0.476806640625}, {"start": 45.48, "end": 46.16, "word": " الـ", "probability": 0.6060791015625}, {"start": 46.16, "end": 46.48, "word": " Amino", "probability": 0.749755859375}, {"start": 46.48, "end": 46.84, "word": " Acid", "probability": 0.781494140625}, {"start": 46.84, "end": 47.26, "word": " الحمض", "probability": 0.94970703125}, {"start": 47.26, "end": 47.86, "word": " الأميني", "probability": 0.946044921875}, {"start": 47.86, "end": 48.76, "word": " الألانين", "probability": 0.9439697265625}, {"start": 48.76, "end": 49.46, "word": " مع", "probability": 0.97412109375}, {"start": 49.46, "end": 50.64, "word": " الألفا", "probability": 0.8310546875}, {"start": 50.64, "end": 51.02, "word": " كيتو", "probability": 0.9397786458333334}, {"start": 51.02, "end": 51.92, "word": " إجلوتارات", "probability": 0.9833984375}, {"start": 51.92, "end": 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الآخر الـ αكيتو إجلوتاريت محصلة النقل إن الألانين هيتحول لـ Pyruvate والـ αكيتو إجلوتاريت هذه المادة هتتحول لـ Glutamate طبعا مش هطلبكوا في المعادلة وفي التحويل بس للعلم و للفهم", "tokens": [6027, 20292, 3714, 29245, 23328, 3660, 8978, 21542, 41260, 16247, 2304, 9957, 16247, 1211, 7649, 9957, 4032, 21292, 47283, 3215, 11296, 4032, 21292, 1863, 7435, 1211, 11296, 15844, 9673, 31747, 3555, 6024, 95, 34740, 2423, 39184, 5691, 4117, 36081, 2407, 11933, 7435, 1211, 35473, 9640, 36081, 3714, 5016, 36520, 3660, 28239, 4587, 1211, 36145, 16247, 1211, 7649, 9957, 39896, 2655, 5016, 12610, 5296, 39184, 9953, 894, 19083, 16070, 39184, 5691, 4117, 36081, 2407, 11933, 7435, 1211, 35473, 9640, 36081, 29538, 9673, 18513, 3660, 8032, 2655, 2655, 5016, 12610, 5296, 39184, 5209, 325, 335, 473, 23032, 3555, 3615, 995, 37893, 8032, 9566, 46152, 4117, 14407, 8978, 9673, 3615, 18513, 37977, 4032, 41185, 16712, 5016, 2407, 26895, 4724, 3794, 24976, 3615, 19528, 4032, 24976, 5172, 16095], "avg_logprob": 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"end": 82.73, "word": " التحويل", "probability": 0.9561767578125}, {"start": 82.73, "end": 84.05, "word": " بس", "probability": 0.817626953125}, {"start": 84.05, "end": 84.89, "word": " للعلم", "probability": 0.88427734375}, {"start": 84.89, "end": 85.13, "word": " و", "probability": 0.49169921875}, {"start": 85.13, "end": 85.61, "word": " للفهم", "probability": 0.9200846354166666}], "temperature": 1.0}, {"id": 5, "seek": 11347, "start": 87.65, "end": 113.47, "text": "الـ Clinical Significance للفحص الأهمية التشخيصية لفحص الـ ALT it is found in the kidneys, heart and skeletal muscle tissue but primarily in the liver tissue بيحكيلي إنزايم الـ ALT وين الأماكن اللي بيكون موجود فيها بشكل أساسي موجود في الكدن والهارت والسكلتال muscle وال RBCs ضيفه كمان", "tokens": [6027, 39184, 47942, 13515, 1089, 719, 24976, 5172, 5016, 9381, 16247, 16095, 10632, 16712, 8592, 9778, 1829, 9381, 10632, 5296, 5172, 5016, 9381, 2423, 39184, 7056, 51, 309, 307, 1352, 294, 264, 35994, 11, 1917, 293, 32321, 304, 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103.35, "end": 104.03, "word": " وين", "probability": 0.94677734375}, {"start": 104.03, "end": 104.67, "word": " الأماكن", "probability": 0.99365234375}, {"start": 104.67, "end": 104.83, "word": " اللي", "probability": 0.962646484375}, {"start": 104.83, "end": 105.19, "word": " بيكون", "probability": 0.9822591145833334}, {"start": 105.19, "end": 105.63, "word": " موجود", "probability": 0.9737955729166666}, {"start": 105.63, "end": 106.05, "word": " فيها", "probability": 0.93505859375}, {"start": 106.05, "end": 106.79, "word": " بشكل", "probability": 0.97314453125}, {"start": 106.79, "end": 107.29, "word": " أساسي", "probability": 0.9853515625}, {"start": 107.29, "end": 107.71, "word": " موجود", "probability": 0.9853515625}, {"start": 107.71, "end": 107.91, "word": " في", "probability": 0.98193359375}, {"start": 107.91, "end": 108.63, "word": " الكدن", "probability": 0.8068033854166666}, {"start": 108.63, "end": 109.87, "word": " والهارت", "probability": 0.67724609375}, {"start": 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"probability": 0.836181640625}, {"start": 207.6, "end": 208.62, "word": " بنتابع", "probability": 0.871337890625}, {"start": 208.62, "end": 209.12, "word": " هذه", "probability": 0.982421875}, {"start": 209.12, "end": 210.04, "word": " الأدوية", "probability": 0.9969482421875}, {"start": 210.04, "end": 210.94, "word": " تمام؟", "probability": 0.8733723958333334}], "temperature": 1.0}, {"id": 10, "seek": 23158, "start": 211.42, "end": 231.58, "text": "often higher than AST with liver damage and tend to remain elevated longer هنا بيحكيلي الـ ALT عادة تركيزه أعلى من الـ AST في حالات liver damage يعني لو صار عندي مشكلة في الكبت liver damage", "tokens": [6750, 268, 2946, 813, 316, 6840, 365, 15019, 4344, 293, 3928, 281, 6222, 23457, 2854, 34105, 4724, 1829, 5016, 4117, 1829, 20292, 2423, 39184, 7056, 51, 6225, 18513, 3660, 6055, 31747, 1829, 11622, 3224, 5551, 3615, 23942, 9154, 2423, 39184, 316, 6840, 8978, 11331, 6027, 9307, 15019, 4344, 37495, 22653, 45164, 20328, 9640, 18871, 16254, 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217.04, "word": " remain", "probability": 0.85791015625}, {"start": 217.04, "end": 218.16, "word": " elevated", "probability": 0.97998046875}, {"start": 218.16, "end": 219.06, "word": " longer", "probability": 0.96240234375}, {"start": 219.06, "end": 220.3, "word": " هنا", "probability": 0.73779296875}, {"start": 220.3, "end": 221.08, "word": " بيحكيلي", "probability": 0.970458984375}, {"start": 221.08, "end": 222.24, "word": " الـ", "probability": 0.6729736328125}, {"start": 222.24, "end": 222.78, "word": " ALT", "probability": 0.7939453125}, {"start": 222.78, "end": 223.54, "word": " عادة", "probability": 0.982421875}, {"start": 223.54, "end": 224.66, "word": " تركيزه", "probability": 0.95439453125}, {"start": 224.66, "end": 225.34, "word": " أعلى", "probability": 0.93896484375}, {"start": 225.34, "end": 225.56, "word": " من", "probability": 0.9921875}, {"start": 225.56, "end": 225.88, "word": " الـ", "probability": 0.878662109375}, {"start": 225.88, "end": 226.48, "word": " AST", 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هيزيد أكتر من الـ AST لأنه أصلا هو تركيزه في الـ liver أكتر وأعلى وبالتالي لما يطلعوا الإتنين ع الدم الـ ALT و الـ AST بيزيدوا بس الـ ALT بيكون أعلى من الـ AST تمام؟ أيضا كمان شغلة", "tokens": [37746, 6027, 2655, 6027, 1829, 2423, 39184, 7056, 51, 4032, 2423, 39184, 316, 6840, 16712, 1863, 9957, 39896, 11622, 25708, 14407, 8978, 32748, 2304, 4724, 3794, 2423, 39184, 7056, 51, 39896, 11622, 25708, 5551, 4117, 2655, 2288, 9154, 2423, 39184, 316, 6840, 5296, 33456, 3224, 5551, 9381, 15040, 31439, 6055, 31747, 1829, 11622, 3224, 8978, 2423, 39184, 15019, 5551, 4117, 2655, 2288, 36725, 3615, 23942, 46599, 6027, 2655, 6027, 1829, 5296, 15042, 7251, 9566, 1211, 3615, 14407, 33688, 2655, 1863, 9957, 6225, 32748, 2304, 2423, 39184, 7056, 51, 4032, 2423, 39184, 316, 6840, 4724, 1829, 11622, 25708, 14407, 4724, 3794, 2423, 39184, 7056, 51, 4724, 1829, 30544, 5551, 3615, 23942, 9154, 2423, 39184, 316, 6840, 46811, 10943, 22807, 36632, 11242, 995, 9122, 2304, 7649, 13412, 17082, 37977], 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{"start": 336.51, "end": 336.77, "word": " يعني", "probability": 0.89794921875}, {"start": 336.77, "end": 337.15, "word": " ممكن", "probability": 0.9873046875}, {"start": 337.15, "end": 337.49, "word": " بعد", "probability": 0.97412109375}, {"start": 337.49, "end": 338.07, "word": " خمس،", "probability": 0.8004150390625}, {"start": 338.07, "end": 338.27, "word": " ست", "probability": 0.982421875}, {"start": 338.27, "end": 338.87, "word": " أيام", "probability": 0.93359375}, {"start": 338.87, "end": 339.75, "word": " الـ", "probability": 0.94970703125}, {"start": 339.75, "end": 340.23, "word": " AST", "probability": 0.870361328125}, {"start": 340.23, "end": 340.85, "word": " يرجع", "probability": 0.9879557291666666}, {"start": 340.85, "end": 341.53, "word": " طبيعي", "probability": 0.9794921875}, {"start": 341.53, "end": 342.59, "word": " ويظل", "probability": 0.9207763671875}, {"start": 342.59, "end": 342.83, "word": " الـ", "probability": 0.952880859375}, {"start": 342.83, "end": 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"text": "من فحص ال ASC تفاجنا إن ال ASC مش متخصص برتفع في حالات الدبح القلبية برتفع في حالات مشاكل الكبد لكن ال ALT بقولك remains normal in acute myocardial infarction يبقى طبيعي في حالات الذبح القلبية إذن هو متخصص أكتر إشي للكبد", "tokens": [27842, 6156, 5016, 9381, 2423, 7469, 34, 6055, 5172, 26108, 8315, 36145, 2423, 7469, 34, 37893, 44650, 9778, 9381, 9381, 4724, 43500, 5172, 3615, 8978, 11331, 6027, 9307, 32748, 49628, 25062, 46152, 10632, 4724, 43500, 5172, 3615, 8978, 11331, 6027, 9307, 37893, 995, 28820, 33251, 44510, 44381, 2423, 7056, 51, 4724, 39648, 4117, 7023, 2710, 294, 24390, 452, 905, 515, 831, 1536, 289, 882, 7251, 3555, 4587, 7578, 23032, 21292, 3615, 1829, 8978, 11331, 6027, 9307, 32545, 49628, 25062, 46152, 10632, 11933, 8848, 1863, 31439, 44650, 9778, 9381, 9381, 5551, 4117, 2655, 2288, 11933, 8592, 1829, 24976, 4117, 44510], "avg_logprob": -0.1158593776077032, "compression_ratio": 1.75, "no_speech_prob": 3.2186508178710938e-06, "words": [{"start": 361.54, "end": 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{"start": 402.96, "end": 403.54, "word": " RBCs", "probability": 0.5684407552083334}, {"start": 403.54, "end": 404.62, "word": " بكميات", "probability": 0.9412841796875}, {"start": 404.62, "end": 405.38, "word": " قليلة", "probability": 0.9793294270833334}, {"start": 405.38, "end": 406.1, "word": " جداً", "probability": 0.9757486979166666}], "temperature": 1.0}, {"id": 19, "seek": 43502, "start": 407.12, "end": 435.02, "text": "مش زي الـ AST، الـ AST موجود في هذه التشوب كميات أكبر وبالتالي الـ ALT موجود في عضلة القلب ولكن كميات قليلة، يعني لما بيصير دمش في القلب ويطلع الـ ALT على الـ Serum، على الدم، مش كتير هيزيد تركيزه أو هيفرج معاه، تمام؟ وبالتالي بيضلوا ضمن الـ Normal Range، إذا فحص الـ ALT متخصص أكتر من فحص الـ AST للكبد", "tokens": [2304, 8592, 30767, 1829, 2423, 39184, 316, 6840, 12399, 2423, 39184, 316, 6840, 3714, 29245, 23328, 8978, 29538, 16712, 8592, 37746, 9122, 2304, 1829, 9307, 5551, 4117, 26890, 46599, 6027, 2655, 6027, 1829, 2423, 39184, 7056, 51, 3714, 29245, 23328, 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"probability": 0.8702392578125}, {"start": 627.49, "end": 628.63, "word": " والنقصان", "probability": 0.93564453125}, {"start": 628.63, "end": 628.79, "word": " في", "probability": 0.9892578125}, {"start": 628.79, "end": 629.55, "word": " الـabsorbance", "probability": 0.93076171875}, {"start": 629.55, "end": 630.55, "word": " هيعبر", "probability": 0.7650146484375}, {"start": 630.55, "end": 630.83, "word": " عن", "probability": 0.94140625}, {"start": 630.83, "end": 632.25, "word": " الـactivity", "probability": 0.7755126953125}, {"start": 632.25, "end": 632.95, "word": " تبعة", "probability": 0.7984619140625}, {"start": 632.95, "end": 633.69, "word": " الـenzyme", "probability": 0.7451171875}, {"start": 633.69, "end": 634.15, "word": " في", "probability": 0.9853515625}, {"start": 634.15, "end": 635.01, "word": " العينة", "probability": 0.9117838541666666}, {"start": 635.01, "end": 635.63, "word": " برضه", "probability": 0.9109700520833334}, {"start": 635.63, "end": 635.89, "word": " ال", "probability": 0.9697265625}, {"start": 635.89, "end": 636.41, "word": " procedure", "probability": 0.623046875}, {"start": 636.41, "end": 637.29, "word": " مش", "probability": 0.9619140625}, {"start": 637.29, "end": 638.37, "word": " مذكورة", "probability": 0.807421875}, {"start": 638.37, "end": 639.17, "word": " هنذكرها", "probability": 0.81318359375}, {"start": 639.17, "end": 639.41, "word": " لما", "probability": 0.93310546875}, {"start": 639.41, "end": 640.01, "word": " نشتغل", "probability": 0.99453125}, {"start": 640.01, "end": 640.87, "word": " الفحص", "probability": 0.8313802083333334}, {"start": 640.87, "end": 641.31, "word": " طبعا", "probability": 0.9500732421875}, {"start": 641.31, "end": 641.53, "word": " احنا", "probability": 0.8095703125}, {"start": 641.53, "end": 641.99, "word": " بنرجع", "probability": 0.7318522135416666}, {"start": 641.99, "end": 642.47, "word": " الجامعة", "probability": 0.9786783854166666}], "temperature": 1.0}, {"id": 28, "seek": 64829, "start": 642.78, "end": 648.3, "text": "يا هنشتغل الـ ALT يا الـ AST لأن الاتنين نفس الـ procedure تمام؟", "tokens": [25528, 8032, 1863, 8592, 2655, 17082, 1211, 2423, 39184, 7056, 51, 35186, 2423, 39184, 316, 6840, 5296, 33456, 2423, 9307, 1863, 9957, 8717, 36178, 2423, 39184, 10747, 46811, 10943, 22807], "avg_logprob": -0.2445816416894236, "compression_ratio": 1.1348314606741574, "no_speech_prob": 0.0, "words": [{"start": 642.78, "end": 643.0, "word": "يا", "probability": 0.71435546875}, {"start": 643.0, "end": 643.74, "word": " هنشتغل", "probability": 0.926025390625}, {"start": 643.74, "end": 643.92, "word": " الـ", "probability": 0.748779296875}, {"start": 643.92, "end": 644.4, "word": " ALT", "probability": 0.866943359375}, {"start": 644.4, "end": 644.76, "word": " يا", "probability": 0.58349609375}, {"start": 644.76, "end": 644.98, "word": " الـ", "probability": 0.905517578125}, {"start": 644.98, "end": 645.38, "word": " AST", "probability": 0.70751953125}, {"start": 645.38, "end": 645.7, "word": " لأن", "probability": 0.716796875}, {"start": 645.7, "end": 646.24, "word": " الاتنين", "probability": 0.7572021484375}, {"start": 646.24, "end": 646.78, "word": " نفس", "probability": 0.98828125}, {"start": 646.78, "end": 647.08, "word": " الـ", "probability": 0.78173828125}, {"start": 647.08, "end": 647.52, "word": " procedure", "probability": 0.87548828125}, {"start": 647.52, "end": 648.3, "word": " تمام؟", "probability": 0.8177083333333334}], "temperature": 1.0}, {"id": 29, "seek": 67705, "start": 656.93, "end": 677.05, "text": "الـ Normal Range لـ ALT عند المال من 13 ل 35 International Unit Per Liter عند الفمان من 10 ل 30 International Unit Per Liter High Serum Levels in Acute Hepatitis يعني الـ ALT", "tokens": [6027, 39184, 21277, 33778, 5296, 39184, 7056, 51, 43242, 9673, 6027, 9154, 3705, 5296, 6976, 9157, 27894, 3026, 16090, 43242, 27188, 2304, 7649, 9154, 1266, 5296, 2217, 9157, 27894, 3026, 16090, 5229, 4210, 449, 16872, 82, 294, 5097, 1169, 30578, 267, 16074, 37495, 22653, 2423, 39184, 7056, 51], "avg_logprob": -0.18670281098813427, "compression_ratio": 1.4026845637583893, "no_speech_prob": 0.0, "words": [{"start": 656.93, "end": 657.31, "word": "الـ", "probability": 0.90625}, {"start": 657.31, "end": 657.55, "word": " Normal", "probability": 0.84375}, {"start": 657.55, "end": 658.21, "word": " Range", "probability": 0.89794921875}, {"start": 658.21, "end": 659.41, "word": " لـ", "probability": 0.821044921875}, {"start": 659.41, "end": 660.05, "word": " ALT", "probability": 0.785888671875}, {"start": 660.05, "end": 660.47, "word": " عند", "probability": 0.8720703125}, {"start": 660.47, "end": 660.97, "word": " المال", "probability": 0.76953125}, {"start": 660.97, "end": 661.95, "word": " من", "probability": 0.86962890625}, {"start": 661.95, "end": 662.45, "word": " 13", "probability": 0.90380859375}, {"start": 662.45, "end": 662.69, "word": " ل", "probability": 0.6787109375}, {"start": 662.69, "end": 663.43, "word": " 35", 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{"start": 669.97, "end": 670.39, "word": " Per", "probability": 0.9306640625}, {"start": 670.39, "end": 670.95, "word": " Liter", "probability": 0.904296875}, {"start": 670.95, "end": 671.89, "word": " High", "probability": 0.69677734375}, {"start": 671.89, "end": 672.49, "word": " Serum", "probability": 0.879150390625}, {"start": 672.49, "end": 673.65, "word": " Levels", "probability": 0.838134765625}, {"start": 673.65, "end": 673.83, "word": " in", "probability": 0.85400390625}, {"start": 673.83, "end": 674.51, "word": " Acute", "probability": 0.884033203125}, {"start": 674.51, "end": 675.59, "word": " Hepatitis", "probability": 0.9568684895833334}, {"start": 675.59, "end": 676.11, "word": " يعني", "probability": 0.83984375}, {"start": 676.11, "end": 676.35, "word": " الـ", "probability": 0.85498046875}, {"start": 676.35, "end": 677.05, "word": " ALT", "probability": 0.931884765625}], "temperature": 1.0}, {"id": 30, "seek": 70051, "start": 677.61, "end": 700.51, "text": "بيكون موجود بتركيز عالي جداً في الـ Serum في حالات الـ Acute Hepatitis الالتهاب الحاد في خلايا الكبد، تمام؟ بيصل تركيز الـ ALT في حالات الـ Acute Hepatitis من 300 لـ 1000 International Unit per Liter، تمام؟", "tokens": [3555, 1829, 30544, 3714, 29245, 23328, 39894, 31747, 1829, 11622, 6225, 6027, 1829, 10874, 28259, 14111, 8978, 2423, 39184, 4210, 449, 8978, 11331, 6027, 9307, 2423, 39184, 5097, 1169, 30578, 267, 16074, 2423, 6027, 2655, 11296, 3555, 21542, 18513, 8978, 16490, 15040, 25528, 33251, 44510, 12399, 46811, 10943, 22807, 4724, 1829, 36520, 6055, 31747, 1829, 11622, 2423, 39184, 7056, 51, 8978, 11331, 6027, 9307, 2423, 39184, 5097, 1169, 30578, 267, 16074, 9154, 6641, 5296, 39184, 9714, 9157, 27894, 680, 16090, 12399, 46811, 10943, 22807], "avg_logprob": -0.13612132703556734, "compression_ratio": 1.6041666666666667, "no_speech_prob": 2.980232238769531e-07, "words": [{"start": 677.61, "end": 678.19, "word": "بيكون", "probability": 0.7152506510416666}, {"start": 678.19, "end": 678.85, "word": " موجود", "probability": 0.9816080729166666}, {"start": 678.85, "end": 679.79, "word": " بتركيز", "probability": 0.942626953125}, {"start": 679.79, "end": 680.43, "word": " عالي", "probability": 0.9833984375}, {"start": 680.43, "end": 680.93, "word": " جداً", "probability": 0.84814453125}, {"start": 680.93, "end": 681.01, "word": " في", "probability": 0.9619140625}, {"start": 681.01, "end": 681.25, "word": " الـ", "probability": 0.744140625}, {"start": 681.25, "end": 681.57, "word": " Serum", "probability": 0.844482421875}, {"start": 681.57, "end": 681.99, "word": " في", "probability": 0.7705078125}, {"start": 681.99, "end": 682.45, "word": " حالات", "probability": 0.9816080729166666}, {"start": 682.45, "end": 682.65, "word": " الـ", "probability": 0.98876953125}, {"start": 682.65, "end": 683.13, "word": " Acute", "probability": 0.6917724609375}, {"start": 683.13, "end": 684.09, "word": " Hepatitis", "probability": 0.95361328125}, {"start": 684.09, "end": 685.51, "word": " الالتهاب", "probability": 0.78203125}, {"start": 685.51, "end": 686.19, "word": " الحاد", "probability": 0.91015625}, {"start": 686.19, "end": 686.55, "word": " في", "probability": 0.9716796875}, {"start": 686.55, "end": 687.23, "word": " خلايا", "probability": 0.9816080729166666}, {"start": 687.23, "end": 688.23, "word": " الكبد،", "probability": 0.7722981770833334}, {"start": 688.23, "end": 689.09, "word": " تمام؟", "probability": 0.9456380208333334}, {"start": 689.09, "end": 689.71, "word": " بيصل", "probability": 0.9578450520833334}, {"start": 689.71, "end": 690.49, "word": " تركيز", "probability": 0.9957275390625}, {"start": 690.49, "end": 690.81, "word": " الـ", "probability": 0.98486328125}, {"start": 690.81, "end": 691.53, "word": " ALT", "probability": 0.922119140625}, {"start": 691.53, "end": 692.05, "word": " في", "probability": 0.94921875}, {"start": 692.05, "end": 692.55, "word": " حالات", "probability": 0.98974609375}, {"start": 692.55, "end": 692.83, "word": " الـ", 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700.99, "end": 718.07, "text": "الـ ALT بيكون بتركيز عالي جدًا موجود في السيرام عند شخص اللي بيكون عنده التهاب حاد في الكبد وبيصل تركيز الانزين من 300 ل1000 IU per liter لكن بيصير له moderate elevation", "tokens": [6027, 39184, 7056, 51, 4724, 1829, 30544, 39894, 31747, 1829, 11622, 6225, 6027, 1829, 10874, 3215, 14111, 995, 3714, 29245, 23328, 8978, 21136, 13546, 10943, 43242, 13412, 9778, 9381, 13672, 1829, 4724, 1829, 30544, 43242, 3224, 16712, 11296, 3555, 11331, 18513, 8978, 33251, 44510, 4032, 21292, 36520, 6055, 31747, 1829, 11622, 2423, 7649, 11622, 9957, 9154, 6641, 5296, 21199, 44218, 680, 2733, 44381, 4724, 1829, 9381, 13546, 46740, 18174, 25827], "avg_logprob": -0.23965669559760833, "compression_ratio": 1.4516129032258065, "no_speech_prob": 3.5762786865234375e-07, "words": [{"start": 700.99, "end": 701.65, "word": "الـ", "probability": 0.7783203125}, {"start": 701.65, "end": 702.27, "word": " ALT", "probability": 0.85693359375}, {"start": 702.27, "end": 703.05, "word": " بيكون", "probability": 0.726806640625}, {"start": 703.05, "end": 704.03, "word": " بتركيز", "probability": 0.9461669921875}, {"start": 704.03, "end": 704.55, "word": " عالي", "probability": 0.9484049479166666}, {"start": 704.55, "end": 704.97, "word": " جدًا", "probability": 0.759735107421875}, {"start": 704.97, "end": 705.45, "word": " موجود", "probability": 0.9557291666666666}, {"start": 705.45, "end": 705.59, "word": " في", "probability": 0.955078125}, {"start": 705.59, "end": 706.09, "word": " السيرام", "probability": 0.6984049479166666}, {"start": 706.09, "end": 706.81, "word": " عند", "probability": 0.880859375}, {"start": 706.81, "end": 707.33, "word": " شخص", "probability": 0.9208984375}, {"start": 707.33, "end": 707.61, "word": " اللي", "probability": 0.863037109375}, {"start": 707.61, "end": 708.01, "word": " بيكون", "probability": 0.8732096354166666}, {"start": 708.01, "end": 708.41, "word": " عنده", "probability": 0.972412109375}, {"start": 708.41, "end": 709.05, "word": " التهاب", "probability": 0.8221028645833334}, {"start": 709.05, "end": 709.31, "word": " حاد", "probability": 0.806396484375}, {"start": 709.31, "end": 709.43, "word": " في", "probability": 0.6826171875}, {"start": 709.43, "end": 709.83, "word": " الكبد", "probability": 0.802734375}, {"start": 709.83, "end": 710.57, "word": " وبيصل", "probability": 0.861328125}, {"start": 710.57, "end": 711.05, "word": " تركيز", "probability": 0.990478515625}, {"start": 711.05, "end": 711.63, "word": " الانزين", "probability": 0.73114013671875}, {"start": 711.63, "end": 711.91, "word": " من", "probability": 0.89453125}, {"start": 711.91, "end": 712.37, "word": " 300", "probability": 0.89697265625}, {"start": 712.37, "end": 713.29, "word": " ل1000", "probability": 0.5892333984375}, {"start": 713.29, "end": 714.23, "word": " IU", "probability": 0.2218017578125}, {"start": 714.23, "end": 714.61, "word": " per", "probability": 0.036651611328125}, {"start": 714.61, "end": 715.05, "word": " liter", 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طبعاً الفات بتبدأ تتراكم على ال liver", "tokens": [9566, 3555, 3615, 995, 14111, 4724, 1829, 38251, 2407, 3224, 3714, 43042, 6055, 8592, 2304, 3615, 33251, 44510, 6055, 8592, 2304, 3615, 33251, 44510, 16472, 3224, 32748, 3224, 11536, 39894, 44510, 10721, 6055, 2655, 23557, 24793, 15844, 2423, 15019, 23032, 3555, 3615, 995, 14111, 27188, 9307, 39894, 44510, 10721, 6055, 2655, 23557, 24793, 15844, 2423, 15019], "avg_logprob": -0.18366228279314542, "compression_ratio": 1.7043478260869565, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 783.42, "end": 784.26, "word": "طبعاً", "probability": 0.84423828125}, {"start": 784.26, "end": 784.88, "word": " بيسموه", "probability": 0.92392578125}, {"start": 784.88, "end": 785.08, "word": " مرض", "probability": 0.840087890625}, {"start": 785.08, "end": 785.86, "word": " تشمع", "probability": 0.90625}, {"start": 785.86, "end": 786.46, "word": " الكبد", "probability": 0.928466796875}, {"start": 786.46, "end": 787.04, "word": " تشمع", 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فيه إلى عدد من النظائر موجودين في organ مختلفة major are thus found الـ ALB موجود في الـ liver في الـ bone في الـ placenta وفي الـ intestine تمام؟", "tokens": [6027, 39184, 286, 539, 268, 1229, 5814, 8717, 19913, 16373, 2288, 2423, 39184, 7056, 33, 7056, 33, 8198, 382, 257, 1230, 295, 286, 539, 268, 1229, 5814, 2423, 39184, 7056, 33, 8978, 3224, 30731, 6225, 3215, 3215, 9154, 28239, 19913, 16373, 2288, 3714, 29245, 23328, 9957, 8978, 1798, 3714, 46456, 46538, 3660, 2563, 366, 8807, 1352, 2423, 39184, 7056, 33, 3714, 29245, 23328, 8978, 2423, 39184, 15019, 8978, 2423, 39184, 9026, 8978, 2423, 39184, 20831, 8938, 4032, 41185, 2423, 39184, 42446, 46811, 10943, 22807], "avg_logprob": -0.2009191169458277, "compression_ratio": 1.6096256684491979, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1131.74, "end": 1132.1, "word": "الـ", "probability": 0.962158203125}, {"start": 1132.1, "end": 1133.22, "word": " Isoenzymes", "probability": 0.77646484375}, {"start": 1133.22, "end": 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Biliary Duct وتحت القناة الصفرية في الأمعاء هلجيت هذه الـBiliary Duct القناة الصفرية الخلايا اللي فيها هذه الخلايا أيضًا موجود فيها الـALB، تمام؟", "tokens": [6027, 20292, 4724, 1829, 36520, 49374, 33251, 44510, 16070, 10721, 2304, 3615, 16606, 13672, 1829, 3714, 29245, 23328, 3660, 6055, 33753, 2423, 39184, 25597, 377, 533, 12174, 8315, 3660, 12399, 25062, 8315, 3660, 31767, 5172, 2288, 10632, 2423, 39184, 33, 38550, 5153, 349, 11933, 8848, 1863, 12399, 8978, 18871, 16254, 9122, 44510, 34683, 33753, 11296, 8978, 12174, 8315, 3660, 20328, 5172, 2288, 10632, 12399, 363, 38550, 5153, 349, 34683, 33753, 25062, 8315, 3660, 31767, 5172, 2288, 10632, 8978, 16247, 2304, 3615, 16606, 8032, 1211, 7435, 36081, 29538, 2423, 39184, 33, 38550, 5153, 349, 25062, 8315, 3660, 31767, 5172, 2288, 10632, 33962, 15040, 25528, 13672, 1829, 8978, 11296, 29538, 33962, 15040, 25528, 36632, 11242, 14111, 995, 3714, 29245, 23328, 8978, 11296, 2423, 39184, 3427, 33, 12399, 46811, 10943, 22807], "avg_logprob": 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"text": "أذن تلت حالات بيرتفع فيهم الـ ALP تكوين الـ stones في القناة الصفرية وجود مشكلة فيه الكبت حالات الـ growth إنه مو عند الأطفال بشكل طبيعي", "tokens": [10721, 8848, 1863, 6055, 1211, 2655, 11331, 6027, 9307, 4724, 13546, 2655, 5172, 3615, 8978, 16095, 2423, 39184, 7056, 47, 6055, 4117, 2407, 9957, 2423, 39184, 14083, 8978, 25062, 8315, 3660, 31767, 5172, 2288, 10632, 49610, 23328, 37893, 28820, 3660, 8978, 3224, 33251, 3555, 2655, 11331, 6027, 9307, 2423, 39184, 4599, 36145, 3224, 3714, 2407, 43242, 16247, 9566, 5172, 6027, 4724, 8592, 28820, 23032, 21292, 3615, 1829], "avg_logprob": -0.2173713219954687, "compression_ratio": 1.45, "no_speech_prob": 0.0, "words": [{"start": 1725.84, "end": 1726.24, "word": "أذن", "probability": 0.5802408854166666}, {"start": 1726.24, "end": 1726.48, "word": " تلت", "probability": 0.7789713541666666}, {"start": 1726.48, "end": 1726.76, "word": " حالات", "probability": 0.8714192708333334}, {"start": 1726.76, "end": 1727.14, "word": " بيرتفع", 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{"start": 2113.83, "end": 2114.57, "word": " reaction", "probability": 0.83349609375}, {"start": 2114.57, "end": 2115.11, "word": " مش", "probability": 0.947265625}, {"start": 2115.11, "end": 2115.41, "word": " زي", "probability": 0.99560546875}, {"start": 2115.41, "end": 2115.63, "word": " الـ", "probability": 0.81884765625}, {"start": 2115.63, "end": 2116.07, "word": " ASC", "probability": 0.86474609375}, {"start": 2116.07, "end": 2116.17, "word": " و", "probability": 0.59619140625}, {"start": 2116.17, "end": 2116.35, "word": " الـ", "probability": 0.633056640625}, {"start": 2116.35, "end": 2116.87, "word": " ALT", "probability": 0.9072265625}, {"start": 2116.87, "end": 2117.49, "word": " الـ", "probability": 0.874267578125}, {"start": 2117.49, "end": 2117.93, "word": " ASC", "probability": 0.9794921875}, {"start": 2117.93, "end": 2118.05, "word": " و", "probability": 0.96435546875}, {"start": 2118.05, "end": 2118.25, "word": " الـ", "probability": 0.728515625}, {"start": 2118.25, 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{"start": 2137.83, "end": 2138.41, "word": " بيشتغل", "probability": 0.977783203125}, {"start": 2138.41, "end": 2138.69, "word": " عليها", "probability": 0.990478515625}, {"start": 2138.69, "end": 2138.95, "word": " الـ", "probability": 0.764892578125}, {"start": 2138.95, "end": 2139.31, "word": " enzyme", "probability": 0.63916015625}, {"start": 2139.31, "end": 2140.45, "word": " ويكسرها", "probability": 0.944091796875}], "temperature": 1.0}, {"id": 97, "seek": 217051, "start": 2140.81, "end": 2170.51, "text": "محصلة التفاعل إعطاء مادة ملونة اللي هي الـB-Nitrophenol لونها أسفر إذا لما بتحط السيرام على الـReagent تحصلت الـReaction لون شدة اللون تتناسب تناسب ترضي مع الـActivity تبع الإنزايم شدة اللون الناتجة تتناسب تناسب ترضي مع الـActivity تبع الإنزايم واضح؟ إذاً Calorimetric reaction عادي جداً", "tokens": [2304, 5016, 36520, 3660, 16712, 5172, 995, 30241, 11933, 3615, 9566, 16606, 3714, 18513, 3660, 3714, 1211, 11536, 3660, 13672, 1829, 39896, 2423, 39184, 33, 12, 45, 270, 11741, 268, 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13546, 2304, 6055, 4587, 16572, 3555, 995, 9154, 3356, 5296, 48804, 9157, 27894, 680, 16090, 6055, 31747, 1829, 11622, 3224, 8978, 32748, 2304], "avg_logprob": -0.17366975706976814, "compression_ratio": 1.0923076923076922, "no_speech_prob": 0.0, "words": [{"start": 2171.95, "end": 2172.33, "word": "الـ", "probability": 0.9482421875}, {"start": 2172.33, "end": 2172.55, "word": " Normal", "probability": 0.87255859375}, {"start": 2172.55, "end": 2173.21, "word": " Range", "probability": 0.955078125}, {"start": 2173.21, "end": 2173.87, "word": " للـ", "probability": 0.85595703125}, {"start": 2173.87, "end": 2174.45, "word": " ALP", "probability": 0.742431640625}, {"start": 2174.45, "end": 2175.05, "word": " موجود", "probability": 0.97265625}, {"start": 2175.05, "end": 2175.17, "word": " في", "probability": 0.962890625}, {"start": 2175.17, "end": 2175.67, "word": " السيرم", "probability": 0.7705078125}, {"start": 2175.67, "end": 2176.43, "word": " تقريبا", "probability": 0.94775390625}, {"start": 2176.43, "end": 2176.85, "word": " من", "probability": 0.79541015625}, {"start": 2176.85, "end": 2177.53, "word": " 40", "probability": 0.95947265625}, {"start": 2177.53, "end": 2178.49, "word": " ل125", "probability": 0.5928955078125}, {"start": 2178.49, "end": 2180.01, "word": " International", "probability": 0.362548828125}, {"start": 2180.01, "end": 2180.63, "word": " Unit", "probability": 0.814453125}, {"start": 2180.63, "end": 2181.03, "word": " per", "probability": 0.52099609375}, {"start": 2181.03, "end": 2181.63, "word": " Liter", "probability": 0.6767578125}, {"start": 2181.63, "end": 2182.73, "word": " تركيزه", "probability": 0.9599609375}, {"start": 2182.73, "end": 2183.01, "word": " في", "probability": 0.990234375}, {"start": 2183.01, "end": 2183.69, "word": " الدم", "probability": 0.97900390625}], "temperature": 1.0}, {"id": 99, "seek": 220813, "start": 2185.01, "end": 2208.13, "text": "الإنزايم التاني الـ Gamma Glutamyl Transferase أو ما يسمى بالـ GGT Gamma Glutamyl Transferase أيضًا هذا الإنزايم الآخر اللي مع الـ ALB التنين بيشيكوا هل فيه كوليستاسز موجودة في الـ Biliary Tract ولا لأ، هل موجود حصاوي في القناة الصفراوية ولا لأ", "tokens": [6027, 28814, 1863, 11622, 995, 32640, 16712, 7649, 1829, 2423, 39184, 24723, 1696, 5209, 325, 335, 5088, 35025, 651, 34051, 19446, 7251, 38251, 7578, 20666, 39184, 42240, 51, 24723, 1696, 5209, 325, 335, 5088, 35025, 651, 36632, 11242, 14111, 995, 23758, 33688, 1863, 11622, 995, 32640, 6024, 95, 34740, 13672, 1829, 20449, 2423, 39184, 7056, 33, 16712, 1863, 9957, 4724, 1829, 8592, 1829, 4117, 14407, 8032, 1211, 8978, 3224, 9122, 12610, 1829, 14851, 32277, 11622, 3714, 29245, 23328, 3660, 8978, 2423, 39184, 363, 38550, 1765, 578, 49429, 5296, 10721, 12399, 8032, 1211, 3714, 29245, 23328, 11331, 9381, 995, 45865, 8978, 25062, 8315, 3660, 31767, 5172, 23557, 2407, 10632, 49429, 5296, 10721], "avg_logprob": -0.1992187567853502, "compression_ratio": 1.7085201793721974, "no_speech_prob": 5.960464477539063e-08, 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2199.15, "word": " بيشيكوا", "probability": 0.8959147135416666}, {"start": 2199.15, "end": 2199.59, "word": " هل", "probability": 0.959716796875}, {"start": 2199.59, "end": 2199.87, "word": " فيه", "probability": 0.94384765625}, {"start": 2199.87, "end": 2200.89, "word": " كوليستاسز", "probability": 0.729736328125}, {"start": 2200.89, "end": 2201.75, "word": " موجودة", "probability": 0.974853515625}, {"start": 2201.75, "end": 2202.03, "word": " في", "probability": 0.97314453125}, {"start": 2202.03, "end": 2202.93, "word": " الـ", "probability": 0.704345703125}, {"start": 2202.93, "end": 2203.39, "word": " Biliary", "probability": 0.5966796875}, {"start": 2203.39, "end": 2204.05, "word": " Tract", "probability": 0.6912841796875}, {"start": 2204.05, "end": 2204.39, "word": " ولا", "probability": 0.626953125}, {"start": 2204.39, "end": 2204.75, "word": " لأ،", "probability": 0.7090657552083334}, {"start": 2204.75, "end": 2204.99, "word": " هل", "probability": 0.92724609375}, {"start": 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اللي بتفحص الـ GGT برضه colorimetric reaction زي و زي فحص الـ ALB بالظبط عشان هيك لما نرجع الجامعة هنشتغل واحد منهم", "tokens": [6027, 39184, 4657, 42263, 337, 24521, 5191, 5933, 47525, 8315, 8717, 8592, 38688, 41950, 2288, 4587, 9673, 14851, 9778, 40448, 3660, 5296, 4587, 25528, 3794, 2423, 39184, 24521, 9122, 2304, 7649, 35186, 10874, 15042, 27884, 9122, 2655, 9307, 8315, 13672, 1829, 39894, 5172, 5016, 9381, 2423, 39184, 42240, 51, 4724, 43042, 3224, 2017, 332, 17475, 5480, 30767, 1829, 4032, 30767, 1829, 6156, 5016, 9381, 2423, 39184, 7056, 33, 20666, 19913, 3555, 9566, 6225, 8592, 7649, 39896, 4117, 5296, 15042, 8717, 47341, 3615, 25724, 10943, 27884, 8032, 1863, 8592, 2655, 17082, 1211, 36764, 24401, 9154, 16095], "avg_logprob": -0.15071615188693008, "compression_ratio": 1.4366812227074235, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 2492.76, "end": 2493.14, "word": "الـ", "probability": 0.854736328125}, {"start": 2493.14, "end": 2493.28, "word": " «Say", 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محصلة التفاعل اعطاء مادة ملونة الـ B-Nitroaniline وشدة اللون اللي اتكونها نتيجة محصلة التفاعل هتتناسب تناسب ترضي مع نشاط الـ enzyme في العينة ومادة الـ B-Nitroaniline هنقرأها على wavelength 405 نانومتر", "tokens": [28814, 15730, 3714, 5016, 36520, 3660, 16712, 5172, 995, 30241, 1975, 3615, 9566, 16606, 3714, 18513, 3660, 3714, 1211, 11536, 3660, 2423, 39184, 363, 12, 45, 270, 340, 282, 388, 533, 4032, 8592, 41891, 13672, 11536, 13672, 1829, 1975, 2655, 30544, 11296, 8717, 31371, 7435, 3660, 3714, 5016, 36520, 3660, 16712, 5172, 995, 30241, 8032, 2655, 2655, 8315, 35457, 6055, 8315, 35457, 6055, 43042, 1829, 20449, 8717, 8592, 41193, 2423, 39184, 24521, 8978, 18863, 9957, 3660, 4032, 15042, 41891, 2423, 39184, 363, 12, 45, 270, 340, 282, 388, 533, 8032, 1863, 4587, 2288, 10721, 11296, 15844, 22907, 3356, 20, 8717, 7649, 20498, 2655, 2288], "avg_logprob": -0.12827381179446265, "compression_ratio": 1.6354679802955665, "no_speech_prob": 0.0, "words": [{"start": 2571.85, "end": 2572.19, 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"end": 2581.47, "word": " اتكونها", "probability": 0.70635986328125}, {"start": 2581.47, "end": 2582.57, "word": " نتيجة", "probability": 0.9853515625}, {"start": 2582.57, "end": 2583.25, "word": " محصلة", "probability": 0.9652099609375}, {"start": 2583.25, "end": 2583.81, "word": " التفاعل", "probability": 0.9752197265625}, {"start": 2583.81, "end": 2584.63, "word": " هتتناسب", "probability": 0.88876953125}, {"start": 2584.63, "end": 2585.21, "word": " تناسب", "probability": 0.8719075520833334}, {"start": 2585.21, "end": 2585.79, "word": " ترضي", "probability": 0.8458658854166666}, {"start": 2585.79, "end": 2586.05, "word": " مع", "probability": 0.99365234375}, {"start": 2586.05, "end": 2586.55, "word": " نشاط", "probability": 0.99169921875}, {"start": 2586.55, "end": 2586.79, "word": " الـ", "probability": 0.858154296875}, {"start": 2586.79, "end": 2587.27, "word": " enzyme", "probability": 0.65087890625}, {"start": 2587.27, "end": 2587.65, "word": " في", "probability": 0.96826171875}, {"start": 2587.65, "end": 2588.53, "word": " العينة", "probability": 0.8761393229166666}, {"start": 2588.53, "end": 2589.55, "word": " ومادة", "probability": 0.8377278645833334}, {"start": 2589.55, "end": 2589.81, "word": " الـ", "probability": 0.94873046875}, {"start": 2589.81, "end": 2589.95, "word": " B", "probability": 0.77001953125}, {"start": 2589.95, "end": 2590.99, "word": "-Nitroaniline", "probability": 0.9873046875}, {"start": 2590.99, "end": 2592.03, "word": " هنقرأها", "probability": 0.9441731770833334}, {"start": 2592.03, "end": 2592.27, "word": " على", "probability": 0.875}, {"start": 2592.27, "end": 2592.83, "word": " wavelength", "probability": 0.95703125}, {"start": 2592.83, "end": 2594.11, "word": " 405", "probability": 0.880615234375}, {"start": 2594.11, "end": 2595.35, "word": " نانومتر", "probability": 0.82734375}], "temperature": 1.0}, {"id": 117, "seek": 261334, "start": 2596.08, "end": 2613.34, "text": "الـ Reference Range عند المال من 6 لـ 45 International Unit Per Liter عند الفمال من 5 ل 30 International Unit Per Liter إذا المادة التفاعل إن السيران موجود في الإنزاين والـreagent فيه الـsubstrate", "tokens": [6027, 39184, 1300, 5158, 33778, 43242, 9673, 6027, 9154, 1386, 5296, 39184, 6905, 9157, 27894, 3026, 16090, 43242, 27188, 2304, 6027, 9154, 1025, 5296, 2217, 9157, 27894, 3026, 16090, 11933, 15730, 9673, 18513, 3660, 16712, 5172, 995, 30241, 36145, 21136, 13546, 7649, 3714, 29245, 23328, 8978, 33688, 1863, 11622, 995, 9957, 16070, 39184, 265, 559, 317, 8978, 3224, 2423, 39184, 30131, 372, 4404], "avg_logprob": -0.21386719308793545, "compression_ratio": 1.5511363636363635, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 2596.08, "end": 2596.4, "word": "الـ", "probability": 0.9296875}, {"start": 2596.4, "end": 2596.86, "word": " Reference", "probability": 0.66015625}, {"start": 2596.86, "end": 2597.48, "word": " Range", "probability": 0.89892578125}, {"start": 2597.48, "end": 2598.02, "word": " عند", "probability": 0.93017578125}, {"start": 2598.02, "end": 2598.48, "word": " المال", "probability": 0.9169921875}, {"start": 2598.48, "end": 2599.1, "word": " من", "probability": 0.865234375}, {"start": 2599.1, "end": 2599.54, "word": " 6", "probability": 0.94384765625}, {"start": 2599.54, "end": 2599.76, "word": " لـ", "probability": 0.702392578125}, {"start": 2599.76, "end": 2600.52, "word": " 45", "probability": 0.8271484375}, {"start": 2600.52, "end": 2601.2, "word": " International", "probability": 0.37890625}, {"start": 2601.2, "end": 2601.74, "word": " Unit", "probability": 0.6787109375}, {"start": 2601.74, "end": 2602.04, "word": " Per", "probability": 0.4423828125}, {"start": 2602.04, "end": 2602.42, "word": " Liter", "probability": 0.76123046875}, {"start": 2602.42, "end": 2603.12, "word": " عند", "probability": 0.83740234375}, {"start": 2603.12, "end": 2603.64, "word": " الفمال", "probability": 0.97265625}, {"start": 2603.64, "end": 2603.94, "word": " من", "probability": 0.9755859375}, {"start": 2603.94, "end": 2604.34, "word": " 5", "probability": 0.93798828125}, {"start": 2604.34, "end": 2604.74, "word": " ل", "probability": 0.98193359375}, {"start": 2604.74, "end": 2605.26, "word": " 30", "probability": 0.88134765625}, {"start": 2605.26, "end": 2606.0, "word": " International", "probability": 0.8828125}, {"start": 2606.0, "end": 2606.62, "word": " Unit", "probability": 0.96435546875}, {"start": 2606.62, "end": 2607.0, "word": " Per", "probability": 0.9609375}, {"start": 2607.0, "end": 2607.5, "word": " Liter", "probability": 0.90673828125}, {"start": 2607.5, "end": 2608.26, "word": " إذا", "probability": 0.86865234375}, {"start": 2608.26, "end": 2608.74, "word": " المادة", "probability": 0.822265625}, {"start": 2608.74, "end": 2609.44, "word": " التفاعل", "probability": 0.961181640625}, {"start": 2609.44, "end": 2609.84, "word": " إن", "probability": 0.60791015625}, {"start": 2609.84, "end": 2610.36, "word": " السيران", "probability": 0.67041015625}, {"start": 2610.36, "end": 2610.76, "word": " موجود", "probability": 0.984375}, {"start": 2610.76, "end": 2610.9, "word": " في", "probability": 0.9755859375}, {"start": 2610.9, "end": 2611.54, "word": " الإنزاين", "probability": 0.743701171875}, {"start": 2611.54, "end": 2612.36, "word": " والـreagent", "probability": 0.7146484375}, {"start": 2612.36, "end": 2612.62, "word": " فيه", "probability": 0.983154296875}, {"start": 2612.62, "end": 2613.34, "word": " الـsubstrate", "probability": 0.78681640625}], "temperature": 1.0}, {"id": 118, "seek": 263594, "start": 2613.48, "end": 2635.94, "text": "لما بحطهم على بعض الـ enzyme هيكسّر ال substrate محصلة التفاعل مادة ملونة احنا بنجيس هذه المادة على wavelength معينة وشدة اللون هتتناسب تناسب تردي مع ال activity تبعت ال enzyme وبهيك بنكون خلصنا chapter liver function test ويعطيكم ألف عافية", "tokens": [1211, 15042, 4724, 5016, 9566, 16095, 15844, 45030, 11242, 2423, 39184, 24521, 39896, 4117, 3794, 11703, 2288, 2423, 27585, 3714, 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الـ", "probability": 0.5660400390625}, {"start": 2615.64, "end": 2615.96, "word": " enzyme", "probability": 0.69482421875}, {"start": 2615.96, "end": 2616.64, "word": " هيكسّر", "probability": 0.83955078125}, {"start": 2616.64, "end": 2616.76, "word": " ال", "probability": 0.94189453125}, {"start": 2616.76, "end": 2617.26, "word": " substrate", "probability": 0.65087890625}, {"start": 2617.26, "end": 2618.42, "word": " محصلة", "probability": 0.8826904296875}, {"start": 2618.42, "end": 2619.12, "word": " التفاعل", "probability": 0.9122314453125}, {"start": 2619.12, "end": 2619.62, "word": " مادة", "probability": 0.9178059895833334}, {"start": 2619.62, "end": 2620.16, "word": " ملونة", "probability": 0.973388671875}, {"start": 2620.16, "end": 2620.72, "word": " احنا", "probability": 0.7508951822916666}, {"start": 2620.72, "end": 2621.24, "word": " بنجيس", "probability": 0.935302734375}, {"start": 2621.24, "end": 2621.5, "word": " هذه", "probability": 0.77392578125}, {"start": 2621.5, "end": 2622.12, "word": " المادة", "probability": 0.9879557291666666}, {"start": 2622.12, "end": 2622.68, "word": " على", "probability": 0.84228515625}, {"start": 2622.68, "end": 2623.12, "word": " wavelength", "probability": 0.87451171875}, {"start": 2623.12, "end": 2623.94, "word": " معينة", "probability": 0.9812825520833334}, {"start": 2623.94, "end": 2624.56, "word": " وشدة", "probability": 0.7459309895833334}, {"start": 2624.56, "end": 2624.92, "word": " اللون", "probability": 0.990966796875}, {"start": 2624.92, "end": 2625.54, "word": " هتتناسب", "probability": 0.96201171875}, {"start": 2625.54, "end": 2626.02, "word": " تناسب", "probability": 0.9267578125}, {"start": 2626.02, "end": 2626.38, "word": " تردي", "probability": 0.8836263020833334}, {"start": 2626.38, "end": 2626.62, "word": " مع", "probability": 0.96826171875}, {"start": 2626.62, "end": 2626.78, "word": " ال", "probability": 0.970703125}, {"start": 2626.78, "end": 2627.42, "word": " activity", "probability": 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\ No newline at end of file
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/OEKZUS3N-iI_raw.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/OEKZUS3N-iI_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..4aac5a1c5f9e25faf2cad60625eecc1e47458e3c
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/OEKZUS3N-iI_raw.srt
@@ -0,0 +1,2060 @@
+1
+00:00:00,770 --> 00:00:04,750
+هنحكي هنا عن الفحص التاني اللي بيشيك على الـ
+
+2
+00:00:04,750 --> 00:00:08,670
+Hepatocellular injury هل خلايا الكبد فيها damage
+
+3
+00:00:08,670 --> 00:00:13,530
+ولا لأ الإنزايم الآخر الـALT Alanine
+
+4
+00:00:13,530 --> 00:00:18,270
+Aminotransferasea transferase with enzymatic
+
+5
+00:00:18,270 --> 00:00:23,410
+activity similar to AST شغلوا يا جماعة نفس شغل الـ
+
+6
+00:00:23,410 --> 00:00:29,650
+AST إيه شغلهم؟ ينجلق أمين جروب مجموعة أمين من مكان
+
+7
+00:00:29,650 --> 00:00:37,360
+لمكان آخر، تمام؟Converts هذا الـ ALT يحول الألانين
+
+8
+00:00:37,360 --> 00:00:42,440
+والألفا كيتو إجلوتارات إلى مادة البيروفات
+
+9
+00:00:42,440 --> 00:00:46,840
+والجلوتامات زي ما انتوا شايفين هي الـ Amino Acid
+
+10
+00:00:46,840 --> 00:00:52,380
+الحمض الأميني الألانين مع الألفا كيتو إجلوتارات في
+
+11
+00:00:52,380 --> 00:00:57,100
+وجود الـ ALT إنزايم إيش بيعمل؟ بنزع الـ Amino
+
+12
+00:00:57,100 --> 00:01:01,630
+Groupاللي موجودة في الحند الأمين الألانين وبياخدها
+
+13
+00:01:01,630 --> 00:01:06,690
+وبينجلها على المركب الآخر الـ αكيتو إجلوتاريت
+
+14
+00:01:06,690 --> 00:01:13,410
+محصلة النقل إن الألانين هيتحول لـ Pyruvate والـ
+
+15
+00:01:13,410 --> 00:01:18,670
+αكيتو إجلوتاريت هذه المادة هتتحول لـ Glutamate
+
+16
+00:01:18,670 --> 00:01:25,130
+طبعا مش هطلبكوا في المعادلة وفي التحويل بس للعلم و
+
+17
+00:01:25,130 --> 00:01:31,030
+للفهمالـ Clinical Significance للفحص الأهمية
+
+18
+00:01:31,030 --> 00:01:35,590
+التشخيصية لفحص الـ ALT it is found in the kidneys,
+
+19
+00:01:35,910 --> 00:01:39,910
+heart and skeletal muscle tissue but primarily in
+
+20
+00:01:39,910 --> 00:01:44,030
+the liver tissue بيحكيلي إنزايم الـ ALT وين
+
+21
+00:01:44,030 --> 00:01:47,910
+الأماكن اللي بيكون موجود فيها بشكل أساسي موجود في
+
+22
+00:01:47,910 --> 00:01:53,470
+الكدن والهارت والسكلتال muscle وال RBCs ضيفه كمان
+
+23
+00:01:53,620 --> 00:01:57,400
+الـ Red Blood Cell خلاية الدم الحمراء موجود في هذه
+
+24
+00:01:57,400 --> 00:02:02,760
+الأماكن يا جماعة بتركيز قليلة جدا لا تسكر تمام؟
+
+25
+00:02:02,760 --> 00:02:07,680
+لكنه موجود بطي primarily ولكن بشكل أساس الـ ALT
+
+26
+00:02:07,680 --> 00:02:12,600
+موجود في خلايا الكبط إذا الـ ALT موجود في الـ
+
+27
+00:02:12,600 --> 00:02:16,280
+kidney والـ heart والـ skeletal muscle والـ RBCs
+
+28
+00:02:16,840 --> 00:02:22,080
+بكميات قليلة جدا لكن فيه ال liver tissue موجود ب
+
+29
+00:02:22,080 --> 00:02:28,040
+high concentration بتركيز عالية تمام في الدم في ال
+
+30
+00:02:28,040 --> 00:02:34,220
+serum زي زي ال AST ال ALT موجود بتركيز قليل جدا
+
+31
+00:02:34,220 --> 00:02:38,960
+هذا الإنسان الطبيعي ال ALT يكون موجود في ال serum
+
+32
+00:02:38,960 --> 00:02:43,830
+ولكن بتركيز قليل لكن وين موجودأكتر إشي في الـ
+
+33
+00:02:43,830 --> 00:02:48,910
+tissue، في الأنثجا، تمام؟ وبشكل أساسي في الكبت الـ
+
+34
+00:02:48,910 --> 00:02:52,470
+test is used mainly in the diagnosis of liver
+
+35
+00:02:52,470 --> 00:02:55,990
+disease and to monitor the effects of hepatotoxic
+
+36
+00:02:55,990 --> 00:03:01,850
+drug الفحص بينعمل بشكل أساسي فحص ال ALT عشان نشخص
+
+37
+00:03:01,850 --> 00:03:06,930
+المشاكل الكبت وخاصة المشاكل اللي بتصيب الخلايا،
+
+38
+00:03:06,930 --> 00:03:13,700
+تمام؟وأيضًا عشان نتابع تأثير الأدوية السامة على
+
+39
+00:03:13,700 --> 00:03:19,260
+الكبد أحيانًا في الـ Drug ممكن بعض الأدوية تأثر
+
+40
+00:03:19,260 --> 00:03:24,520
+على الكبد تمام؟ وتأثر على خلايا الكبد وتعمل injury
+
+41
+00:03:24,520 --> 00:03:30,040
+فيها فإحنا من خلال فحص الـ ALT بنتابع هذه الأدوية
+
+42
+00:03:30,040 --> 00:03:35,940
+تمام؟often higher than AST with liver damage and
+
+43
+00:03:35,940 --> 00:03:42,780
+tend to remain elevated longer هنا بيحكيلي الـ ALT
+
+44
+00:03:42,780 --> 00:03:48,220
+عادة تركيزه أعلى من الـ AST في حالات liver damage
+
+45
+00:03:48,220 --> 00:03:53,160
+يعني لو صار عندي مشكلة في الكبت liver damageالـ
+
+46
+00:03:53,160 --> 00:03:57,720
+AST والـ ALT التانيين موجودين في الكبت، تمام؟ بس
+
+47
+00:03:57,720 --> 00:04:02,220
+مين موجود أكتر في الكبت الـ ALT؟ الـ ALT موجود في
+
+48
+00:04:02,220 --> 00:04:06,700
+الكبت بتركيز عالي كتير، أعلى من الـ AST فلما بيصير
+
+49
+00:04:06,700 --> 00:04:11,860
+عندي مشكلة في الكبت، هيطلع الـ ALT والـ AST لبرا،
+
+50
+00:04:11,860 --> 00:04:17,110
+ع الدم، تمام؟وبالتالي الـ ALT و الـ AST التنين
+
+51
+00:04:17,110 --> 00:04:22,050
+هيزيدوا في الدم بس الـ ALT هيزيد أكتر من الـ AST
+
+52
+00:04:22,050 --> 00:04:28,250
+لأنه أصلا هو تركيزه في الـ liver أكتر وأعلى
+
+53
+00:04:28,250 --> 00:04:32,690
+وبالتالي لما يطلعوا الإتنين ع الدم الـ ALT و الـ
+
+54
+00:04:32,690 --> 00:04:38,510
+AST بيزيدوا بس الـ ALT بيكون أعلى من الـ AST تمام؟
+
+55
+00:04:38,510 --> 00:04:44,250
+أيضا كمان شغلةإذاً كمان شغلة تانية بدنا نعرفها إنه
+
+56
+00:04:44,250 --> 00:04:49,090
+غير إن الـ ALT بيكون أعلى من الـ AST في حالات
+
+57
+00:04:49,090 --> 00:04:54,390
+liver damage كمان الـ ALT بيظلوا عالي في الدم
+
+58
+00:04:54,390 --> 00:05:02,690
+لفترة أطول من الـ AST حكينا إنه يعنيmore liver
+
+59
+00:05:02,690 --> 00:05:07,930
+يعني كمان شغلة تانية more liver specific than AST
+
+60
+00:05:07,930 --> 00:05:13,510
+إذا في تلت شغلات بدنا ناخدها بعين الاعتبار ال ALT
+
+61
+00:05:13,510 --> 00:05:18,050
+في الكبد تركيزه أعلى من ال AST فلما بيصير liver
+
+62
+00:05:18,050 --> 00:05:24,070
+damage التنين بيطلعوا على الدم لكن في الدم ال ALT
+
+63
+00:05:24,070 --> 00:05:30,490
+هيكون تركيزه أعلى من ال ASTومش بس هيك كمان الـ ALT
+
+64
+00:05:30,490 --> 00:05:37,150
+بيظل عالي لفترة طويلة أطول من الـ AST يعني ممكن
+
+65
+00:05:37,150 --> 00:05:43,270
+بعد خمس، ست أيام الـ AST يرجع طبيعي ويظل الـ ALT
+
+66
+00:05:43,270 --> 00:05:49,150
+عالي في الـ Serumتمام شغلة تالتة بيحكيلنا إن الـ
+
+67
+00:05:49,150 --> 00:05:57,230
+ALT يعتبر متخصص أكتر من الـ AST متخصص للكبد فحص
+
+68
+00:05:57,230 --> 00:06:03,700
+الـ ALT متخصص أكتر في الكبدمن فحص ال ASC تفاجنا إن
+
+69
+00:06:03,700 --> 00:06:09,280
+ال ASC مش متخصص برتفع في حالات الدبح القلبية برتفع
+
+70
+00:06:09,280 --> 00:06:14,860
+في حالات مشاكل الكبد لكن ال ALT بقولك remains
+
+71
+00:06:14,860 --> 00:06:20,040
+normal in acute myocardial infarction يبقى طبيعي
+
+72
+00:06:20,040 --> 00:06:25,400
+في حالات الذبح القلبية إذن هو متخصص أكتر إشي للكبد
+
+73
+00:06:25,960 --> 00:06:30,260
+ليش يا جماعة، مع إنه هتسألوني، هتحكولي طيب الـ ALT
+
+74
+00:06:30,260 --> 00:06:34,880
+هيه موجود في القلب حكيناه، وفي الـ kidney طيب ليش
+
+75
+00:06:34,880 --> 00:06:39,140
+في حالات الدبح القلبية ما بيزيد؟ لإنه حكيتلكم هو
+
+76
+00:06:39,140 --> 00:06:42,200
+موجود في الـ kidney و الـ heart و الـ skeletal
+
+77
+00:06:42,200 --> 00:06:48,420
+muscle و الـ RBCs بكميات قليلة جداًمش زي الـ AST،
+
+78
+00:06:48,420 --> 00:06:52,760
+الـ AST موجود في هذه التشوب كميات أكبر وبالتالي
+
+79
+00:06:52,760 --> 00:06:56,680
+الـ ALT موجود في عضلة القلب ولكن كميات قليلة، يعني
+
+80
+00:06:56,680 --> 00:07:00,320
+لما بيصير دمش في القلب ويطلع الـ ALT على الـ
+
+81
+00:07:00,320 --> 00:07:05,220
+Serum، على الدم، مش كتير هيزيد تركيزه أو هيفرج
+
+82
+00:07:05,220 --> 00:07:09,020
+معاه، تمام؟ وبالتالي بيضلوا ضمن الـ Normal Range،
+
+83
+00:07:09,020 --> 00:07:15,020
+إذا فحص الـ ALT متخصص أكتر من فحص الـ AST للكبد
+
+84
+00:07:17,040 --> 00:07:21,580
+الـ Specimen Collection نوع العينة زي الـ AST سيرم
+
+85
+00:07:21,580 --> 00:07:25,140
+أو بلازمة البلازمة نوع الـ Anticoagulant إدتا أو
+
+86
+00:07:25,140 --> 00:07:30,820
+هيبرين تمام؟ لأنه كمان الـ ALT موجود جوات الـ RBCs
+
+87
+00:07:30,820 --> 00:07:35,240
+يعني بدي أتجنب أجمع عينة Hemolyse و العينة الـ
+
+88
+00:07:35,240 --> 00:07:39,660
+Hemolyse بدي أعملها rejection أرفضها ليش؟ لأنه لو
+
+89
+00:07:39,660 --> 00:07:44,600
+العينة سرقلها Hemolysis هيطلع الـ ALT من الـ RBCs
+
+90
+00:07:44,600 --> 00:07:48,630
+على السيرمويزيد تركيزه في الـ Serum بشكل خاطئ
+
+91
+00:07:48,630 --> 00:07:56,770
+معلومة إن الـ ALT موجود بالـ RBCs تقريبا بـ 5
+
+92
+00:07:56,770 --> 00:08:01,010
+أضعاف الـ ALT اللي موجود في الـ Serum يعني هو
+
+93
+00:08:01,010 --> 00:08:07,090
+موجود في الـ RBCs ولكن 5 أضعاف، تمام؟ لو بتتذكروا
+
+94
+00:08:07,090 --> 00:08:13,600
+الـ AST موجود الـ AST في الـ RBCs بـ 15 دعفيعني
+
+95
+00:08:13,600 --> 00:08:19,880
+الـ AST موجود في الـ RBCs بكميات أكبر من الـ ALT
+
+96
+00:08:19,880 --> 00:08:25,020
+تمام؟ هذه معلومة مهمة الـ AST موجود في الـ RBCs
+
+97
+00:08:25,020 --> 00:08:31,740
+بكميات أكبر من الـ ALT الـ «Say for enzyme
+
+98
+00:08:31,740 --> 00:08:36,140
+activity» قياس الـ activity تبعة الإنزايم الطرق
+
+99
+00:08:36,140 --> 00:08:41,460
+المستخدمة في قياس الـ activity تبعة إنزايم الـ ALT
+
+100
+00:08:42,350 --> 00:08:48,250
+طبعا الطريقة ومبدأ الشغل نفس مبدأ شغل الـ AST مش
+
+101
+00:08:48,250 --> 00:08:52,030
+هي أنزمات كلها نفس المبدأ الكلام المكتوب بالـ
+
+102
+00:08:52,030 --> 00:08:58,330
+slide تلخيصه في المربع اللي تحت الأبيض هذا الـ
+
+103
+00:08:58,330 --> 00:09:02,430
+principle مبدأ الفحص نفس الـ AST بالظبط يا جماعة
+
+104
+00:09:03,290 --> 00:09:07,070
+الـ Serum تبع ال patient بيكون فيه الـ ALT الـ
+
+105
+00:09:07,070 --> 00:09:10,490
+enzyme اللي أنا بدي أحسب ال activity تبعته بدي
+
+106
+00:09:10,490 --> 00:09:15,390
+أحسب نشاطه لأنه نشاطه هيعبر عن الـ concentration
+
+107
+00:09:15,390 --> 00:09:25,350
+لهذا الـ enzyme تمام؟ هلجيت؟ الألانين والألفا
+
+108
+00:09:25,350 --> 00:09:32,870
+كيتو إجلترات هذي substrate موجودة في الـ reagentهل
+
+109
+00:09:32,870 --> 00:09:35,990
+جات الألانين حكيناه والـ Alpha-ketoglutarate
+
+110
+00:09:35,990 --> 00:09:40,950
+سبستريت هذه المواد موجودة في الـ Reagent لما نخلط
+
+111
+00:09:40,950 --> 00:09:45,710
+الـ Reagent على عينة المريض على السيرام الـ ALT
+
+112
+00:09:45,710 --> 00:09:49,670
+الموجود في السيرام هيشتغل على السبستريت اللي
+
+113
+00:09:49,670 --> 00:09:53,630
+موجودة في الـ Reagent ويحول الألانين لـ Pyruvate
+
+114
+00:09:53,630 --> 00:09:57,930
+والـ Alpha-ketoglutarate لـ Glutamateالبيروفيات
+
+115
+00:09:57,930 --> 00:10:02,250
+هيرتبط مع الـ NADH في وجود إنذايم اسمه لكتات
+
+116
+00:10:02,250 --> 00:10:07,390
+ديهيدروجيناذ حيعطيني لكتات و NADH الـ Decrease في
+
+117
+00:10:07,390 --> 00:10:12,030
+الـ Absorbance يعني الـ NADH اتحولت لـ NADH صارلها
+
+118
+00:10:12,030 --> 00:10:15,390
+reductionيعني حيصير في عندي decrease في
+
+119
+00:10:15,390 --> 00:10:20,110
+الـabsorbance هذا النقصان في الـabsorbance هنقرأه
+
+120
+00:10:20,110 --> 00:10:24,230
+على 340 nanometer الـ wavelength يعني في منطقة
+
+121
+00:10:24,230 --> 00:10:30,550
+الـUV وهذا التفاعل والنقصان في الـabsorbance هيعبر
+
+122
+00:10:30,550 --> 00:10:35,890
+عن الـactivity تبعة الـenzyme في العينة برضه ال
+
+123
+00:10:35,890 --> 00:10:41,310
+procedure مش مذكورة هنذكرها لما نشتغل الفحص طبعا
+
+124
+00:10:41,310 --> 00:10:45,700
+احنا بنرجع الجامعةيا هنشتغل الـ ALT يا الـ AST لأن
+
+125
+00:10:45,700 --> 00:10:48,300
+الاتنين نفس الـ procedure تمام؟
+
+126
+00:10:56,930 --> 00:11:03,430
+الـ Normal Range لـ ALT عند المال من 13 ل 35
+
+127
+00:11:03,430 --> 00:11:08,410
+International Unit Per Liter عند الفمان من 10 ل 30
+
+128
+00:11:08,410 --> 00:11:13,830
+International Unit Per Liter High Serum Levels in
+
+129
+00:11:13,830 --> 00:11:19,790
+Acute Hepatitis يعني الـ ALTبيكون موجود بتركيز
+
+130
+00:11:19,790 --> 00:11:23,130
+عالي جداً في الـ Serum في حالات الـ Acute
+
+131
+00:11:23,130 --> 00:11:29,090
+Hepatitis الالتهاب الحاد في خلايا الكبد، تمام؟
+
+132
+00:11:29,090 --> 00:11:35,050
+بيصل تركيز الـ ALT في حالات الـ Acute Hepatitis من
+
+133
+00:11:35,050 --> 00:11:41,650
+300 لـ 1000 International Unit per Liter، تمام؟الـ
+
+134
+00:11:41,650 --> 00:11:46,810
+ALT بيكون بتركيز عالي جدًا موجود في السيرام عند
+
+135
+00:11:46,810 --> 00:11:50,570
+شخص اللي بيكون عنده التهاب حاد في الكبد وبيصل
+
+136
+00:11:50,570 --> 00:11:56,590
+تركيز الانزين من 300 ل1000 IU per liter لكن بيصير
+
+137
+00:11:56,590 --> 00:12:02,850
+له moderate elevationالـ Moderate elevation يعني
+
+138
+00:12:02,850 --> 00:12:07,530
+الـ ALT بيصيرله ارتفاع بشكل متوسط في حالات الـ
+
+139
+00:12:07,530 --> 00:12:11,130
+Alcohol Hepatitis يعني Hepatitis معناه التهاب في
+
+140
+00:12:11,130 --> 00:12:15,370
+خلايا الكبد Alcohol Hepatitis ان اللي سبب التهاب
+
+141
+00:12:15,370 --> 00:12:20,660
+في خلايا الكبد تناول الكحولاتمن 100 لـ 300
+
+142
+00:12:20,660 --> 00:12:24,620
+International Unit per Liter بارتفاع الـ ALT في
+
+143
+00:12:24,620 --> 00:12:28,220
+السيرام في حالة الـ Alcohol Hepatitis Minor
+
+144
+00:12:28,220 --> 00:12:33,780
+elevation بارتفاع الـ ALT بشكل بسيط في حالات
+
+145
+00:12:33,780 --> 00:12:38,900
+السيروسيز تليفات الكبد الـ Hepatitis C التهاب
+
+146
+00:12:38,900 --> 00:12:43,320
+الكبد نتيجة الفيروس
+
+147
+00:12:45,360 --> 00:12:52,320
+Hepatitis C نتيجة فيروس تلتهب خلايا الكبد وأيضا في
+
+148
+00:12:52,320 --> 00:12:57,600
+حالة الـ Non-alcohol Stetohepatitis اللي اختصاره
+
+149
+00:12:57,600 --> 00:13:04,260
+NASH الـ Non-alcohol Stetohepatitis هذا مرضطبعاً
+
+150
+00:13:04,260 --> 00:13:10,660
+بيسموه مرض تشمع الكبد تشمع الكبد انه الدهون بتبدأ
+
+151
+00:13:10,660 --> 00:13:15,860
+تتراكم على ال liver طبعاً الفات بتبدأ تتراكم على
+
+152
+00:13:15,860 --> 00:13:21,110
+ال liverومش بد ضرورة يصيب الناس اللي بتناولوا كحول
+
+153
+00:13:21,110 --> 00:13:24,350
+يعني بيسمونا alcohol يعني اللي بينصابوا فيه كمان
+
+154
+00:13:24,350 --> 00:13:28,490
+ما بيشربوا كحول انه نحكي مثلا من الكحول هي عاملة
+
+155
+00:13:28,490 --> 00:13:34,350
+هذه المشكلة هدول الأشخاص المشكلة عندهم metabolic
+
+156
+00:13:34,350 --> 00:13:40,500
+syndrome يعني opacity نتيجة الزيادة في الوزننتيجة
+
+157
+00:13:40,500 --> 00:13:44,560
+ارتفاع السكر في الدم بميكانيزمات معينة، الضهون
+
+158
+00:13:44,560 --> 00:13:51,100
+عندهم تتراكم على الكبد، برضه هدول الأشخاصبيصير
+
+159
+00:13:51,100 --> 00:13:55,660
+عندهم Minor Innovation ارتفاع بسيط في الـ ALT
+
+160
+00:13:55,660 --> 00:14:00,280
+تقريبا من 50 لـ 100 International Unit per Liter
+
+161
+00:14:00,280 --> 00:14:04,560
+بيرتفع طبعا الـ Non-alcoholistetohepatitis لو
+
+162
+00:14:04,560 --> 00:14:09,460
+حبيته تعرفوا هذا المرض ممكن على جوجل تشوفه و
+
+163
+00:14:09,460 --> 00:14:17,400
+تبحثوا عنه تمامLevels of AST and ALT AST is
+
+164
+00:14:17,400 --> 00:14:21,960
+assessed along ALT الـ Monitoring Liver Damage يا
+
+165
+00:14:21,960 --> 00:14:28,000
+جماعة ما بينطلب كل فحص لحاله عادة الـ AST والـ ALT
+
+166
+00:14:28,000 --> 00:14:33,540
+اتنين بينطلبوا مع بعض عشان نشيط على وضع الكبد
+
+167
+00:14:33,540 --> 00:14:39,610
+ونشوف هل حدث liver damage or not تمام؟These two
+
+168
+00:14:39,610 --> 00:14:44,990
+values normally exist in an approximately واحد
+
+169
+00:14:44,990 --> 00:14:51,250
+لواحد ratio عند الإنسان الطبيعي الـ AST والـ ALT
+
+170
+00:14:51,250 --> 00:14:57,030
+التنين تقريبا في السيرم نفس التركيز فال ratio
+
+171
+00:14:57,030 --> 00:15:02,830
+لإلهم واحد لواحد يعني موجودين بالسيرم ب ratio واحد
+
+172
+00:15:02,830 --> 00:15:07,390
+لواحد نفس التركيز تقريبا هذا عند الإنسان الطبيعي،
+
+173
+00:15:07,390 --> 00:15:13,240
+تمام؟as a rough guide لكن في حالات مرضية ممكن
+
+174
+00:15:13,240 --> 00:15:19,860
+انزايم يزيد عن الانزايم الآخر مثلا الـ AST بيكون
+
+175
+00:15:19,860 --> 00:15:24,460
+أعلى من الـ ALT في حالة الـ Alcohol Hepatitis
+
+176
+00:15:24,460 --> 00:15:28,260
+التهاب الكبد نتيجة تناول الكحول حالات الـ
+
+177
+00:15:28,260 --> 00:15:33,040
+Cirrhosis تليفات الكبد حالات الـ Metastatic Cancer
+
+178
+00:15:33,040 --> 00:15:38,700
+of Liver حالات انتقال الكنسر بيكون الكنسر من مكان
+
+179
+00:15:39,230 --> 00:15:45,750
+وبيجي بنتقل على ال liver الـ non-pilary cirrhosis
+
+180
+00:15:45,750 --> 00:15:50,670
+تليفات بتخص الكبد ما بتخص القناة نفسها القناة
+
+181
+00:15:50,670 --> 00:15:58,060
+الصفراويةلكن الـ ALT بيكون أعلى من الـ AST في
+
+182
+00:15:58,060 --> 00:16:03,320
+حالات الـ Viral End Drug Hepatitis يعني التهاد
+
+183
+00:16:03,320 --> 00:16:10,040
+خلايا الكبد نتيجة فيروس أو نتيجة تناول أدوية أثرت
+
+184
+00:16:10,040 --> 00:16:15,210
+بسميتها على الكبدالـ Chronic Hepatitis C التهاب
+
+185
+00:16:15,210 --> 00:16:21,590
+الكبت نتيجة برضه فيروس وهذه حالة صارت لما بدخل
+
+186
+00:16:21,590 --> 00:16:25,690
+الفيروس وممكن تظلها الحالة chronic، مزمنة حالات
+
+187
+00:16:25,690 --> 00:16:29,590
+الـ Hepatic Obstruction انثداد في الـ Bile Reduct
+
+188
+00:16:29,590 --> 00:16:34,390
+في القناع الصفراوية لمابعد الكبت هذه حالات الـ ALT
+
+189
+00:16:34,390 --> 00:16:41,190
+بزيد فيها أكتر من الـ ASD تمام؟هل جيت؟ هنشوف
+
+190
+00:16:41,190 --> 00:16:47,290
+مجموعة من الفحوصات هذه الفحوصات أيضًا بتشيك هل في
+
+191
+00:16:47,290 --> 00:16:52,210
+عندنا كلستاثث عندنا حصاوي Stons سواء في الكبد نفسه
+
+192
+00:16:52,210 --> 00:16:56,490
+وبالتالي هيأثر على الخلايا تبعته أو في الـBiliary
+
+193
+00:16:56,490 --> 00:17:02,010
+duct في القناع السفراوية في Stons ولا لا أول فحص
+
+194
+00:17:02,010 --> 00:17:06,330
+هو الـALB الـAlkaline Phosphatase Enzyme
+
+195
+00:17:07,530 --> 00:17:12,090
+Phosphatases transfer a phosphate moiety from one
+
+196
+00:17:12,090 --> 00:17:16,430
+group to a second Forming an alcohol and a second
+
+197
+00:17:16,430 --> 00:17:20,330
+phosphate compound تعالوا نشوف التفاعل ال reaction
+
+198
+00:17:20,330 --> 00:17:26,020
+هنفهم الكلامهلجيت يا جماعة انزايم الـ ALB بيشتغل
+
+199
+00:17:26,020 --> 00:17:31,220
+at alkaline pH يعني بده medium media تكون هذه ال
+
+200
+00:17:31,220 --> 00:17:36,680
+media قاعدية بيئة قاعدية من تسعة لعشر ال pH لازم
+
+201
+00:17:36,680 --> 00:17:42,120
+يكون تمام الـ ALB ال substrate هذا الانزايم اللي
+
+202
+00:17:42,120 --> 00:17:44,980
+له substrate اللي له مادة بيشتغل عليها اسم ال
+
+203
+00:17:44,980 --> 00:17:50,940
+substrate فوسفو مونيستر فوسفو مونو إيسترهذا الـ
+
+204
+00:17:50,940 --> 00:17:55,760
+enzyme بيجعل هذه الـ substrate و بيكثرها محصلة
+
+205
+00:17:55,760 --> 00:18:01,180
+التكسير هيعطيني الكحول و هيعطيني فوسفات ايون لما
+
+206
+00:18:01,180 --> 00:18:06,180
+المادة تتفاعل مع الميّه إذا فوسفة monoester مع
+
+207
+00:18:06,180 --> 00:18:11,830
+الميّه في وجود ال ALB هيعطيني كحول و فوسفات ايونAt
+
+208
+00:18:11,830 --> 00:18:16,770
+alkaline pH The optimal reaction pH for ALP is
+
+209
+00:18:16,770 --> 00:18:22,450
+between 9 و10 عشان ال enzyme يشتغل بده pH تكون من
+
+210
+00:18:22,450 --> 00:18:27,210
+9 ل 10 and that is with the buffer and substrate
+
+211
+00:18:27,210 --> 00:18:32,590
+طبعا مش بس الفوسفة منيستر هي ال substrate لل
+
+212
+00:18:32,590 --> 00:18:36,840
+enzyme فيه substrate أخرى تمام؟هذا الـ enzyme
+
+213
+00:18:36,840 --> 00:18:40,920
+require مغنيسيوم as an activator عشان يشتغل بده
+
+214
+00:18:40,920 --> 00:18:44,380
+محفظ، بده co-factor هذا الـ enzyme عشان يشتغل بده
+
+215
+00:18:44,380 --> 00:18:49,240
+محفظ المحفظ تبعه هو المغنيسيوم، تمام؟
+
+216
+00:18:51,740 --> 00:18:58,640
+الـ Isoenzymes نظائر الـ ALB ALB exists as a
+
+217
+00:18:58,640 --> 00:19:03,820
+number of Isoenzymes الـ ALB فيه إلى عدد من
+
+218
+00:19:03,820 --> 00:19:11,080
+النظائر موجودين في organ مختلفة major are thus
+
+219
+00:19:11,080 --> 00:19:15,580
+found الـ ALB موجود في الـ liver في الـ bone في
+
+220
+00:19:15,580 --> 00:19:20,430
+الـ placenta وفي الـ intestine تمام؟إذا في عندي
+
+221
+00:19:20,430 --> 00:19:24,510
+ALB موجود في الكبت وموجود في العضام وموجود في الـ
+
+222
+00:19:24,510 --> 00:19:30,430
+placenta وموجود في الأمعاة هلجيت كيف لو بدنا نفرج
+
+223
+00:19:30,430 --> 00:19:37,310
+كل ALB عن الـ ALB الآخر أنا في عندي ALB موجود في
+
+224
+00:19:37,310 --> 00:19:39,510
+الكبت، في الـ bone، في الـ placenta، في الـ
+
+225
+00:19:39,510 --> 00:19:44,870
+intestine هذه كلها مظائر للإنزايمكلها تتشارك مع
+
+226
+00:19:44,870 --> 00:19:49,790
+بعضها في خصائص و بتختلف مع بعضها في خصائص كيف بدي
+
+227
+00:19:49,790 --> 00:19:55,190
+أفرج بينهم و أفصلهم بتقنية الـ Electrophoresis
+
+228
+00:19:55,190 --> 00:20:00,010
+تفصل الـ ALB الأربعة اللي جاية من الكبط و الـ bone
+
+229
+00:20:00,010 --> 00:20:06,340
+و الـ placenta و الـ intestineوبتحسب تركيز كل ALB
+
+230
+00:20:06,340 --> 00:20:09,880
+على حدة يعني الـ ALB اللي جاي من اللفر بتم حساب
+
+231
+00:20:09,880 --> 00:20:14,260
+تركيزه من البون، من الـ placenta، من الـ intestine
+
+232
+00:20:14,260 --> 00:20:20,380
+بواسطة الـ Electrophoresis بحكي للـ ALBهذا النظير
+
+233
+00:20:20,380 --> 00:20:24,980
+اللي بيكون في الكبد على الـ Electrophoresis على
+
+234
+00:20:24,980 --> 00:20:30,140
+الجل أو الـ cellulose acetate بيمشي بشكل أسرع لكن
+
+235
+00:20:30,140 --> 00:20:34,240
+الـ ALB اللي بيطلع من الـ intestine في الـ
+
+236
+00:20:34,240 --> 00:20:37,680
+Electrophoresis أثناء الفصل لما بيمشي بيكون قطة
+
+237
+00:20:37,680 --> 00:20:44,530
+واحد هذه من خصائصهم، تمام؟أو تقنية أخرى هي
+
+238
+00:20:44,530 --> 00:20:48,810
+immunochemical بيعتبروا أن الـ enzyme هذا النظير
+
+239
+00:20:48,810 --> 00:20:53,700
+الـ ALB Antigenالـ Enzyme عبارة عن الـ Antigen
+
+240
+00:20:53,700 --> 00:20:59,060
+بروح يجيبوا Antibody متخصص لهذا الـ Antigen فالـ
+
+241
+00:20:59,060 --> 00:21:02,620
+Antibody بربط بالـ Enzyme و بعطيني Complex
+
+242
+00:21:02,620 --> 00:21:06,540
+Antibody Antigen Reaction بحسب هذا الـ Complex
+
+243
+00:21:06,540 --> 00:21:14,040
+بطرق منعية عشان أشوف تركيز الـ Enzyme تمام؟ لكن يا
+
+244
+00:21:14,040 --> 00:21:21,160
+جماعة هنا بدنا نبّح على شغلالـ ALB موجود في الـ
+
+245
+00:21:21,160 --> 00:21:26,060
+serum تبع الإنسان بتركيز قليلة جدا زي و زي الـ ALT
+
+246
+00:21:26,060 --> 00:21:33,920
+و الـ ASTلكن في حال إجاني شخص فحصله الـ ALB اللي
+
+247
+00:21:33,920 --> 00:21:38,220
+في الـ Serum و لاجئته عالي كتير كتير كتير هذا
+
+248
+00:21:38,220 --> 00:21:44,000
+بيعطيك مؤشر على شو انه حدث اندي damage في ال organ
+
+249
+00:21:44,000 --> 00:21:49,080
+طيب أي organ بالظبط؟ هل حدث damage في ال liver ولا
+
+250
+00:21:49,080 --> 00:21:52,560
+في ال bone ولا في ال placenta ولا في ال intestine
+
+251
+00:21:52,560 --> 00:21:58,860
+ما بتقدر تعرفي من خلال الفحص تمام؟إذا فحص الـ ALP
+
+252
+00:21:58,860 --> 00:22:04,220
+لو كان الـ ALP عالي كتير في الدم بعطيكي مؤشر إن
+
+253
+00:22:04,220 --> 00:22:08,480
+هذا الشخص عنده tissue damage عنده تدمير في الخلايا
+
+254
+00:22:08,480 --> 00:22:12,960
+وفي أعضاء معينة طب إيش هذه ال organ اللي صار إليها
+
+255
+00:22:12,960 --> 00:22:16,560
+damage؟ هل الكبد اتدمر؟ ولا البون اتدمر؟ ولا
+
+256
+00:22:16,560 --> 00:22:19,700
+البلاسنتا؟ ولا ال intestine؟ ما دولة أربع مناطق
+
+257
+00:22:19,700 --> 00:22:26,430
+فيهم ALP مابنعرف، تمام؟لو بدى أعرف وين الدمج
+
+258
+00:22:26,430 --> 00:22:31,910
+بالظبط بتروحى تعملى الـ Electrophoresis عشان تشوف
+
+259
+00:22:31,910 --> 00:22:36,990
+الـ ALB اللى جاي من الكبد و الـ ALB اللى جاي من
+
+260
+00:22:36,990 --> 00:22:40,070
+البعض و الـ ALB اللى جاى من الـ placenta و الـ ALB
+
+261
+00:22:40,070 --> 00:22:44,410
+اللى جاى من الـ intestine مين أعلى واحد في التركيز
+
+262
+00:22:44,410 --> 00:22:49,920
+طبعا فى جهاز اسمه Densitometerبحد التركيز كل واحد
+
+263
+00:22:49,920 --> 00:22:54,180
+على حده فبتعرف اللي أعلى في التركيز معناه هذا
+
+264
+00:22:54,180 --> 00:22:58,700
+العضو هو اللي صار في الدمش، تمام؟ عشان هيك فحص ال
+
+265
+00:22:58,700 --> 00:23:04,780
+ALP مش متخصص للكبد برتفع في حالات مشاكل العضام،
+
+266
+00:23:04,780 --> 00:23:09,520
+مشاكل البلاسنتا، مشاكل الأمعة، تمام؟ هذه الشغله
+
+267
+00:23:09,520 --> 00:23:15,030
+كتير ضرورية نفهمهاالـ Clinical Significance بدنا
+
+268
+00:23:15,030 --> 00:23:20,650
+نحكي عن أهمية أنزايم الـ ALB أهمية هذا الفحص
+
+269
+00:23:20,650 --> 00:23:25,010
+alkaline phosphatase is an enzyme found in the
+
+270
+00:23:25,010 --> 00:23:29,440
+liver pan placenta intestine and kidneysالـ ALB
+
+271
+00:23:29,440 --> 00:23:33,800
+عبارة عن إنزايم موجود في الـ tissue كتيرة في الكبد
+
+272
+00:23:33,800 --> 00:23:36,320
+و في البان و في الـ placenta و الـ intestine و الـ
+
+273
+00:23:36,320 --> 00:23:40,680
+kidneys و لو قرأته مقالة هيحكيلكم إن الـ ALB موجود
+
+274
+00:23:40,680 --> 00:23:44,520
+في كل الـ organ في كل الـ tissue اللي موجودة في
+
+275
+00:23:44,520 --> 00:23:49,580
+الجسم فيها ALB تمام؟ تركيزه في الدم قليل جدا هذا
+
+276
+00:23:49,580 --> 00:23:55,410
+الوضع الطبيعي لكن مكانه أصلي جوات الخلاياA
+
+277
+00:23:55,410 --> 00:24:00,610
+primarily in the cells lining the biliary tract
+
+278
+00:24:00,610 --> 00:24:06,570
+يعني يا جماعة كمان الـ ALB موجود في الخلايا اللي
+
+279
+00:24:06,570 --> 00:24:11,230
+بتكون الـ biliary tract القناة السفراوية هالجدل دي
+
+280
+00:24:11,230 --> 00:24:16,690
+اكم تتخيلوا معي فوق في الكبداللي بيصل بين الكبد
+
+281
+00:24:16,690 --> 00:24:20,590
+والأمعاء اللي موجودة تحت الـIntestine قناة، القناة
+
+282
+00:24:20,590 --> 00:24:25,470
+الصفرية الـBiliary Duct إذن، في عندي كبد وتحتها في
+
+283
+00:24:25,470 --> 00:24:30,270
+قناة صفرية، Biliary Duct وتحت القناة الصفرية في
+
+284
+00:24:30,270 --> 00:24:34,990
+الأمعاء هلجيت هذه الـBiliary Duct القناة الصفرية
+
+285
+00:24:34,990 --> 00:24:40,030
+الخلايا اللي فيها هذه الخلايا أيضًا موجود فيها
+
+286
+00:24:40,030 --> 00:24:51,350
+الـALB، تمام؟أيضًا هذه الخلايا اللي بتكون القناة
+
+287
+00:24:51,350 --> 00:24:57,410
+الصفراوية لو اتكون في القناة stones حصاوي هذه
+
+288
+00:24:57,410 --> 00:25:03,010
+الحصاوية هتدمر الخلايا وبالتالي الخلايا هتبدأ تفرز
+
+289
+00:25:03,010 --> 00:25:10,530
+ALB إذا انتفضنا الـ ALB موجودبشكل أساسي في الخلايا
+
+290
+00:25:10,530 --> 00:25:17,010
+اللي بتكون القناع الصفراوية فلو اتكونت حصاوي في
+
+291
+00:25:17,010 --> 00:25:21,190
+القناع الصفراوية هتأثر على الخلايا الموجودة هناك
+
+292
+00:25:21,190 --> 00:25:27,210
+وبالتاليهتبدأ الخلايا تفرز ALP ويزيد تركيزه في
+
+293
+00:25:27,210 --> 00:25:31,850
+الدم عشان هيك حكينا إن الـ ALP يعني بنعتبره مؤشر
+
+294
+00:25:31,850 --> 00:25:38,170
+لوجود كوليستاسز لوجود حصاوي في القناة الصفرية إذن
+
+295
+00:25:38,170 --> 00:25:42,610
+كمان شغلة بدأ أحكيلكم إنه كمان لما بيصير عندي دمش
+
+296
+00:25:42,610 --> 00:25:47,310
+في خلايا الكبد يعني خلايا الكبد اضدمرت برضه الـ
+
+297
+00:25:47,310 --> 00:25:52,260
+ALP هيزيد في الدملأن الكبد برضه بفرز ALB تمام؟
+
+298
+00:25:52,260 --> 00:25:57,400
+وبالتالي هيطلع الـ ALB من الكبد على الدم ولكن بشكل
+
+299
+00:25:57,400 --> 00:26:02,720
+أكبر الـ ALB بيزيد كتير كتير كتير لما بتتكون حصاوي
+
+300
+00:26:02,720 --> 00:26:07,040
+في القناع الصفراوية لأن هذه الحصاوية اللي في
+
+301
+00:26:07,040 --> 00:26:11,700
+القناع هتأثر على الخلايا اللي في القناع وبالتالي
+
+302
+00:26:12,360 --> 00:26:18,700
+هتبدأ تفرز ALB ويزيد تركيزه بشكل أكبر، تمام؟ أيضًا
+
+303
+00:26:18,700 --> 00:26:24,860
+الـ ALB بيكون موجود في الـ Osteoplast الخلايا
+
+304
+00:26:24,860 --> 00:26:30,340
+البنائية للعدم، تمام؟ involved in the formation of
+
+305
+00:26:30,340 --> 00:26:34,310
+a new bone الجثة العضام لما تنبنيتحتاج لـ
+
+306
+00:26:34,310 --> 00:26:39,690
+Osteoplast خلايا بناء عشان تبنيها هذه الخلايا برضه
+
+307
+00:26:39,690 --> 00:26:47,190
+بتفرذ ALB جواها في ALB تمام؟ فالـ ALB is normally
+
+308
+00:26:47,190 --> 00:26:53,030
+executed from the liver in the bile برضه الـ ALB
+
+309
+00:26:53,030 --> 00:27:00,190
+يا جماعة بشكل طبيعي بيصيرله executionمن الكبد إلى
+
+310
+00:27:00,190 --> 00:27:08,790
+الـ Biliary Duct للقناة السفرية بشكل طبيعي زيادة
+
+311
+00:27:08,790 --> 00:27:16,370
+الـ ALP زيادة الـ ALP بنشوفه بشكل شائع عند الـ
+
+312
+00:27:16,370 --> 00:27:20,790
+Bonne Growth عند الـ Children الأطفالالأطفال،
+
+313
+00:27:20,790 --> 00:27:24,870
+الأطفال، مش بنحكي، بيكونوا في مرحلة بناء للعضم
+
+314
+00:27:24,870 --> 00:27:29,390
+تبعهم البناء، يعني خلايا الـ Osteoplast بدها تبدأ
+
+315
+00:27:29,390 --> 00:27:34,070
+تشتغل، الخلايا البناءة الخلايا هذه بتبدأ تفرذ
+
+316
+00:27:34,070 --> 00:27:39,390
+أثناء بناء الإظام، بتبدأ تفرذ الـ ALB لأنه فيها
+
+317
+00:27:39,390 --> 00:27:44,660
+ALB، تمام؟وبالتالي عند الأطفال لو فحصنا ALP حالة
+
+318
+00:27:44,660 --> 00:27:49,260
+جيه عالى عندهم مش عالى لإن عندهم حالات مرضية عالى
+
+319
+00:27:49,260 --> 00:27:53,240
+لإن هم في مرحلة بناء ال osteoblast الخلايا البناءة
+
+320
+00:27:53,240 --> 00:27:57,020
+تحت العضم تبدأ تشتغل عندهم وبالتالي أثناء شغلها
+
+321
+00:27:57,020 --> 00:28:01,520
+بيصير في release لل ALP بيطلع ال ALP على الدم
+
+322
+00:28:01,520 --> 00:28:07,100
+ويرتفع تركيزهأيضًا الـ ALP بيرتفع في حالات liver
+
+323
+00:28:07,100 --> 00:28:11,180
+disease مشاكل الكبط لأنه أصلا هو موجود في الكبط صح
+
+324
+00:28:11,180 --> 00:28:15,140
+ولا لأ؟ فأي دمش في الكبط هيطلع على الدم ويزيد
+
+325
+00:28:15,140 --> 00:28:19,460
+تركيزه برضه ال ALP بيزيد في حالات ال binary
+
+326
+00:28:19,460 --> 00:28:25,120
+obstruction انسداد في القناة الصفراوية نتيجة تكوين
+
+327
+00:28:25,120 --> 00:28:29,610
+stones حكينا القناة الصفراويةلو اتكونت فيها حصاوي
+
+328
+00:28:29,610 --> 00:28:35,870
+الخلايا اللي كونت القناع أصلا فيها ALB وبالتالي
+
+329
+00:28:35,870 --> 00:28:40,830
+وجود الحصاوي في هذه الخلايا هيدمرها ويخليها تفرز
+
+330
+00:28:40,830 --> 00:28:47,640
+ALB منها للدم، تمام؟أذن تلت حالات بيرتفع فيهم الـ
+
+331
+00:28:47,640 --> 00:28:52,700
+ALP تكوين الـ stones في القناة الصفرية وجود مشكلة
+
+332
+00:28:52,700 --> 00:28:56,820
+فيه الكبت حالات الـ growth إنه مو عند الأطفال بشكل
+
+333
+00:28:56,820 --> 00:29:02,780
+طبيعيSerum ALB Activity Primarily Reflects
+
+334
+00:29:02,780 --> 00:29:06,740
+الـChanges في الـBone وLiver Function طبعا تركيز
+
+335
+00:29:06,740 --> 00:29:12,400
+الـ ALB نشاط الـ ALB بيعكس مدى التغيرات اللي بتسير
+
+336
+00:29:12,400 --> 00:29:17,340
+في الكبط و البون أكيد لأنه أصلا هو موجود في الكبط
+
+337
+00:29:17,340 --> 00:29:22,100
+وموجود في البون فأي مشكلة فيهم في ال liver أو في
+
+338
+00:29:22,100 --> 00:29:27,100
+البون هيأثر على تركيز ال ALBبالتالي، حتى لو كان
+
+339
+00:29:27,100 --> 00:29:31,880
+هناك عملية ALP أعلى ممكن تجدها في أعضاء أخرى برضه
+
+340
+00:29:31,880 --> 00:29:40,270
+الـ ALP موجودة في أعضاء أخرى وبتركيز عاليةعلى
+
+341
+00:29:40,270 --> 00:29:44,110
+الرغم من أن الـ ALB تفاجنا موجود في كل الـ tissue
+
+342
+00:29:44,110 --> 00:29:49,030
+في كل الـ organ لكن فعلياً الـ activity تبعت الـ
+
+343
+00:29:49,030 --> 00:29:54,530
+ALB أكتر إشي يعني تتأثر في مشاكل ال liver و ال
+
+344
+00:29:54,530 --> 00:29:57,910
+bone هم اللي بيحددوا تركيز ال ALB ال liver و ال
+
+345
+00:29:57,910 --> 00:30:02,350
+bone على الرغم من أنه موجود في organ أخرى بتركيز
+
+346
+00:30:02,350 --> 00:30:08,780
+عالية تمام؟Specimen collection جمع العينة a blood
+
+347
+00:30:08,780 --> 00:30:12,720
+should be drawn after a fast of at least 8 hours
+
+348
+00:30:12,720 --> 00:30:18,140
+يعني لما بنعمل فحص ال ALP يفضل يفضل أن نصوم 8
+
+349
+00:30:18,140 --> 00:30:22,980
+ساعات قبل إجراء الفحص العينة سيرم أو بلازمة نوع ال
+
+350
+00:30:22,980 --> 00:30:29,480
+anticoagulant المسموح فقط فيه هو الهيبرين slight
+
+351
+00:30:29,480 --> 00:30:35,440
+hemolysis isTolerable يعني لما بيكون العينة انت
+
+352
+00:30:35,440 --> 00:30:38,220
+شايفة فيه Hemolysis شايفة انه فيه تكسير في
+
+353
+00:30:38,220 --> 00:30:42,060
+الاربيسيز ولكن slight بسيط أو خفيف بقبلها
+
+354
+00:30:42,060 --> 00:30:46,200
+tolerable تمام but gross Hemolysis لو جاتني عينة
+
+355
+00:30:46,200 --> 00:30:52,560
+الاربيسيز أغلبها مكسر اجرس Hemolysis اجرس يعني ال
+
+356
+00:30:52,560 --> 00:30:56,360
+Hemolysis كتير كتير شديد هذه should be avoided
+
+357
+00:30:56,360 --> 00:31:03,190
+يعني بأرفض العينة تماماإذن بفهم إن الـ ALB أيضًا
+
+358
+00:31:03,190 --> 00:31:07,190
+موجود جوّات الـ RBCs متفاجنة، موجود في كل أنسجة
+
+359
+00:31:07,190 --> 00:31:10,590
+الجسم تقريبًا، هذا الـ enzyme موجود في كل أنسجة
+
+360
+00:31:10,590 --> 00:31:15,570
+الجسم، حتى الـ RBCs، تمام؟ الـ point الرابع من
+
+361
+00:31:15,570 --> 00:31:20,190
+الشريحة ما بدنا إياهانجي للـ point الخامسة it is
+
+362
+00:31:20,190 --> 00:31:24,630
+best to analyze ال ALB specimens the same day they
+
+363
+00:31:24,630 --> 00:31:29,290
+are drawn يفضل ما انخزن العينة اللي بديها يعني ما
+
+364
+00:31:29,290 --> 00:31:32,510
+أخزن ال serum أو البلازمة في التلاجة أو بالفريزر
+
+365
+00:31:32,510 --> 00:31:36,310
+عشان أشتغل ال ALB وفضل في اليوم اللي بجمع فيه
+
+366
+00:31:36,310 --> 00:31:41,830
+العينة أفحص ال enzyme على طول، تمام؟الـ ALB is
+
+367
+00:31:41,830 --> 00:31:46,650
+inhibited bymetal-complexing anticoagulant إيش
+
+368
+00:31:46,650 --> 00:31:51,730
+يعني؟ يعني الإديتا والأجزالات والسترات هذه الـ
+
+369
+00:31:51,730 --> 00:31:56,670
+anticoagulant ممنوع أسحب فيها تمام؟ إديتا،
+
+370
+00:31:56,670 --> 00:32:01,410
+أجزالات، سترات ممنوع أسحب فيهم ليش؟ لأن كل هذه الـ
+
+371
+00:32:01,410 --> 00:32:07,250
+anticoagulant بتشتغل كـ chelating agent بتشتغل
+
+372
+00:32:07,750 --> 00:32:12,830
+فتسحب المغنيسيوم تمام؟ المغنيسيوم اتفاجنا هذا الـ
+
+373
+00:32:12,830 --> 00:32:18,930
+Co-Factor لـ ALB هو المسئول عن نشاط إنزايم الـ ALB
+
+374
+00:32:18,930 --> 00:32:23,690
+فلو انسحب المغنيسيوم لو أنا جماعة عينت الدم
+
+375
+00:32:23,690 --> 00:32:28,010
+بإيديتا أو أجزالات أو ستريات هذه الـ Anticoagulant
+
+376
+00:32:28,010 --> 00:32:31,920
+تشتغل Calculating Agent تسحب المغنيسيوموبالتالي
+
+377
+00:32:31,920 --> 00:32:35,120
+الـ ALB مش هيشتغل الـ enzyme مش هيشتغل على الـ
+
+378
+00:32:35,120 --> 00:32:39,440
+substrate تبعته لإن الـ cofactor تم سحبه عشان هيك
+
+379
+00:32:39,440 --> 00:32:44,180
+ممنوعة هذه الـ anticoagulant لإنه بتعمل inhibit لل
+
+380
+00:32:44,180 --> 00:32:50,080
+enzyme بتثبت ال ALB كيف بتثبته من خلال إنها بتسحب
+
+381
+00:32:50,080 --> 00:32:55,420
+المغنيسيوم عشان هيك ممنوع الجمع بهذه الـ
+
+382
+00:32:55,420 --> 00:33:01,500
+anticoagulantassay for enzyme activity بدنا نشوف
+
+383
+00:33:01,500 --> 00:33:06,740
+الطرق المستخدمة لقياس نشاط ال ALP almost all
+
+384
+00:33:06,740 --> 00:33:11,520
+assays for ALP employ P-Nitrophenyl Phosphate as
+
+385
+00:33:11,520 --> 00:33:16,660
+the substrate تقريبا كل الطرق وكل الكتاتالـ
+
+386
+00:33:16,660 --> 00:33:20,820
+Reagent بيحتوي على الـ Substrate إيش هذه الـ
+
+387
+00:33:20,820 --> 00:33:25,840
+Substrate؟ اسمها الـ B-Nitro Phenyl Phosphate هذه
+
+388
+00:33:25,840 --> 00:33:32,030
+الـ Substrate تبع إنزايم الـ ALB تمام؟هلجيت،
+
+389
+00:33:32,030 --> 00:33:35,330
+انتبهوا تحت في الـReaction بدنا نتخيل كيف
+
+390
+00:33:35,330 --> 00:33:40,570
+الـReaction حيصير الـALB هذا الـEnzyme موجود في
+
+391
+00:33:40,570 --> 00:33:43,650
+الـPatient Serum أو الـPatient Plasma وأنا بدي
+
+392
+00:33:43,650 --> 00:33:48,190
+أقيس الـActivity تبعتها الـReagent بيكون جاي من
+
+393
+00:33:48,190 --> 00:33:52,830
+الـCAT الـReagent بيكون في الـCAT جاي من شركة
+
+394
+00:33:52,830 --> 00:33:57,610
+معينة الـReagent يحتوي على Substrate اسمها الـB
+
+395
+00:33:57,610 --> 00:34:02,910
+-Nitrophenyl Phosphateوهذا الـ Substrate colorless
+
+396
+00:34:02,910 --> 00:34:09,030
+ما إلها أي لون تمام؟ والـ pH تبع الـ reagent هي
+
+397
+00:34:09,030 --> 00:34:12,810
+alkaline media لأن اتفجنا الـ ALP بيشتغل على
+
+398
+00:34:12,810 --> 00:34:18,150
+alkaline media عشرة point اتنين الـ pH هل جيت لما
+
+399
+00:34:18,150 --> 00:34:21,990
+تخلط الـ reagent ادريه وتحطيه على ال serum تبع ال
+
+400
+00:34:21,990 --> 00:34:26,640
+patient؟الـAlB الموجود في السيرام هيكسّر
+
+401
+00:34:26,640 --> 00:34:30,240
+الـsubstrate الموجودة في الـreagent اللي هي الـB
+
+402
+00:34:30,240 --> 00:34:37,080
+-Nitrophenyl Phosphate محصلة التكسير هينتج عندنا
+
+403
+00:34:37,080 --> 00:34:44,400
+مُركّب اسمه الـB-Nitrophenol-Phosphate-Ion الـB
+
+404
+00:34:44,400 --> 00:34:50,760
+-Nitrophenol هذه مادة إملونة، تمام؟هذه المادة
+
+405
+00:34:50,760 --> 00:34:57,080
+بيصيرلها انتصاص على 405 نانومتر بتم قراءتها على
+
+406
+00:34:57,080 --> 00:35:01,810
+الـ Spectrophotometerواللون اللي بينتج محصلة
+
+407
+00:35:01,810 --> 00:35:06,470
+التفاعل هو لون أصفر يعني بدنا نفهم أن طريقة الشغل
+
+408
+00:35:06,470 --> 00:35:11,810
+عادي جدا زي كأنه بفحص فحص سكر أو بروتين أو ألبومان
+
+409
+00:35:11,810 --> 00:35:16,350
+أو دهون colorometric reaction مش زي الـ ASC و الـ
+
+410
+00:35:16,350 --> 00:35:20,770
+ALT الـ ASC و الـ ALT اللي هم procedure معينة الـ
+
+411
+00:35:20,770 --> 00:35:26,950
+ALP لأ colorometric سهل جدا طريقة التفاعلالـ ALB
+
+412
+00:35:26,950 --> 00:35:30,850
+موجود في الـ Serum لما بنحط عليه الـ Reagent الـ
+
+413
+00:35:30,850 --> 00:35:35,150
+Reagent بيحتوي على مادة الـ B-Nitrophenylfosfate
+
+414
+00:35:35,150 --> 00:35:39,310
+هذه مادة غير ملونة لما بيشتغل عليها الـ enzyme
+
+415
+00:35:39,310 --> 00:35:45,610
+ويكسرهامحصلة التفاعل إعطاء مادة ملونة اللي هي الـB
+
+416
+00:35:45,610 --> 00:35:50,370
+-Nitrophenol لونها أسفر إذا لما بتحط السيرام على
+
+417
+00:35:50,370 --> 00:35:55,350
+الـReagent تحصلت الـReaction لون شدة اللون تتناسب
+
+418
+00:35:55,350 --> 00:36:00,250
+تناسب ترضي مع الـActivity تبع الإنزايم شدة اللون
+
+419
+00:36:00,250 --> 00:36:05,330
+الناتجة تتناسب تناسب ترضي مع الـActivity تبع
+
+420
+00:36:05,330 --> 00:36:09,930
+الإنزايم واضح؟ إذاً Calorimetric reaction عادي
+
+421
+00:36:09,930 --> 00:36:15,670
+جداًالـ Normal Range للـ ALP موجود في السيرم
+
+422
+00:36:15,670 --> 00:36:21,630
+تقريبا من 40 ل125 International Unit per Liter
+
+423
+00:36:21,630 --> 00:36:27,930
+تركيزه في الدمالإنزايم التاني الـ Gamma Glutamyl
+
+424
+00:36:27,930 --> 00:36:32,950
+Transferase أو ما يسمى بالـ GGT Gamma Glutamyl
+
+425
+00:36:32,950 --> 00:36:37,150
+Transferase أيضًا هذا الإنزايم الآخر اللي مع الـ
+
+426
+00:36:37,150 --> 00:36:42,930
+ALB التنين بيشيكوا هل فيه كوليستاسز موجودة في الـ
+
+427
+00:36:42,930 --> 00:36:46,430
+Biliary Tract ولا لأ، هل موجود حصاوي في القناة
+
+428
+00:36:46,430 --> 00:36:50,400
+الصفراوية ولا لأهذا الـ enzyme إيش ال reaction
+
+429
+00:36:50,400 --> 00:36:56,060
+تبعه؟ مش مطلوب نحفظه بس بدنا نحكيه Transfers الـ
+
+430
+00:36:56,060 --> 00:37:00,340
+Gamma Glutamyl Residue from Gamma Glutamyl Peptide
+
+431
+00:37:00,340 --> 00:37:04,940
+usually Glutathione to Amino Acid H2O and other
+
+432
+00:37:04,940 --> 00:37:09,840
+small peptides Glutathione serves as the Gamma
+
+433
+00:37:09,840 --> 00:37:15,080
+Glutamyl donor إيه جزء ده؟ شوف الصندوق الأزرق هذا
+
+434
+00:37:15,080 --> 00:37:19,800
+الـ Glutathione عبارة عن حمض أمينةالـ «Gamma
+
+435
+00:37:19,800 --> 00:37:22,940
+Glutamyl Transferase» هذا الـ إنزايم إيش بيعمل؟
+
+436
+00:37:22,940 --> 00:37:27,920
+بنجل الـ «Gamma Glutamyl Residue» من الـ
+
+437
+00:37:27,920 --> 00:37:33,320
+«Glutathione» وبيوديها على أمينو أسد آخر الأمينو
+
+438
+00:37:33,320 --> 00:37:37,100
+أسد آخر اللي هنا الأخر اللي هنا هو الـ cysteine
+
+439
+00:37:37,100 --> 00:37:42,420
+محصلة التفاعل لـ «Glutathione» هيتحول لـ «Glutamyl
+
+440
+00:37:42,420 --> 00:37:49,090
+Peptide»ويتكون عندي مركب اسمه الـ cysteine glycine
+
+441
+00:37:50,630 --> 00:37:55,550
+الوظيفة الأساسية له بنجل مجموعة الـ Gamma Glutamyl
+
+442
+00:37:55,550 --> 00:38:01,430
+من الـ Glutathione لأمينو أسد آخر يعني بيشتغل كـ
+
+443
+00:38:01,430 --> 00:38:07,110
+donor كمعطي لـ Gamma Glutamyl تمام؟ الـ
+
+444
+00:38:07,110 --> 00:38:12,190
+Glutathione بيشتغل كـ donor كمعطي لـ group إيش هو
+
+445
+00:38:12,190 --> 00:38:16,820
+الـ group؟ هو الـ Gamma Glutamylالـ GGT بيحكيلك
+
+446
+00:38:16,820 --> 00:38:20,880
+موجود بتركيز عالي جداً في الـ liver is a high
+
+447
+00:38:20,880 --> 00:38:24,600
+concentration in liver tissue موجود بتركيز عالي
+
+448
+00:38:24,600 --> 00:38:28,760
+جداً في الكبد أيضاً موجود في الـ kidney وموجود في
+
+449
+00:38:28,760 --> 00:38:33,260
+الـ pancreas وضيفوا عليها موجود أيضاً في الخلايا
+
+450
+00:38:33,260 --> 00:38:39,880
+اللي كونت ال bilary tract القناع الصفراوية تمام؟
+
+451
+00:38:39,880 --> 00:38:46,680
+وموجود في الدم بالوضع الطبيعي بتركيز قليلالـ
+
+452
+00:38:46,680 --> 00:38:50,520
+Diagnostic Significance أهمية فحص الـ GGT
+
+453
+00:38:50,520 --> 00:38:54,880
+Increased plasma GGT is associated with
+
+454
+00:38:54,880 --> 00:38:59,980
+hepatopilary disease يعني الـ GGT يا جماعة بيرتفع
+
+455
+00:38:59,980 --> 00:39:06,260
+لما بيصير عنده damage فيه أوالـ Stones حصاوي في
+
+456
+00:39:06,260 --> 00:39:10,100
+الـ Biliary Tract في القناة الصفرية وبالتالي
+
+457
+00:39:10,100 --> 00:39:14,300
+الحصاوي هتأثر على الخلايا الموجودة في هذه المنطقة
+
+458
+00:39:14,300 --> 00:39:20,020
+هذه الخلايا هتبدأ تفرز ash تفرز الـ GGT للبلازما،
+
+459
+00:39:20,020 --> 00:39:26,160
+تمام؟Highest seen in the bilary obstruction في
+
+460
+00:39:26,160 --> 00:39:31,460
+حالات الانتداد في القناع الصفراوية بسبب تكوين
+
+461
+00:39:31,460 --> 00:39:35,680
+Estones بيكون يعني تركيزه عالي كتير كتير برضه في
+
+462
+00:39:35,680 --> 00:39:39,380
+حالات الـ Alcohol cirrhosis تلايه في الكبد اللي
+
+463
+00:39:39,380 --> 00:39:44,020
+سببه تناول الكحول برضه بيرتفع الـ GGT في البلازمة
+
+464
+00:39:44,840 --> 00:39:50,500
+هلجيت فحص الـ GGT used with ALB يعني بينعملوا
+
+465
+00:39:50,500 --> 00:39:54,760
+التنين مع بعض to differentiate between liver and
+
+466
+00:39:54,760 --> 00:39:59,420
+bone disease عشان نميز هل المشكلة في الكبد ولا
+
+467
+00:39:59,420 --> 00:40:02,580
+المشكلة بالعظام خلّيني أركز على هذا اللقطة عشان
+
+468
+00:40:02,580 --> 00:40:07,660
+كتير مهمة حكينا إن الـ ALB موجود في الكبد وموجود
+
+469
+00:40:07,660 --> 00:40:13,390
+في العظاملكن الـ GGT موجود في الكبت بس مش موجود في
+
+470
+00:40:13,390 --> 00:40:17,570
+العظام فانت لما بتعمل الاتنين مع بعض تخيل إيجاني
+
+471
+00:40:17,570 --> 00:40:22,530
+مريض اعملتله ALB و GGT الاتنين مع بعض وطلع الاتنين
+
+472
+00:40:22,530 --> 00:40:28,250
+عليين كتير معناه أكيد في عندي مشكلة في الكبت مشكلة
+
+473
+00:40:28,250 --> 00:40:31,430
+في القدرات السفرية فيها حصاوي لما يكونوا الاتنين
+
+474
+00:40:31,430 --> 00:40:36,190
+عليين تمام؟ لكن إيجاني مريض تاني اعملتله الاتنين
+
+475
+00:40:36,190 --> 00:40:41,940
+مع بعض ال ALB و ال GGTطلع الـ ALB عنده عالي بس الـ
+
+476
+00:40:41,940 --> 00:40:48,820
+GGT normal إذاً هذا بيأكد عنده إن المشكلة عنده في
+
+477
+00:40:48,820 --> 00:40:53,040
+البان مشكلة في العظام الـ GGT عنده طلعة طبيعية
+
+478
+00:40:53,040 --> 00:40:57,960
+يعني القناة السفرية عندهم طبيعية والكبد عندهم
+
+479
+00:40:57,960 --> 00:41:03,060
+طبيعي إذا الـ ALB ارتفع لحاله معناه دا indication
+
+480
+00:41:03,060 --> 00:41:07,230
+إن المشكلة في البانلأن هو لحاله موجود في الـ bone
+
+481
+00:41:07,230 --> 00:41:12,550
+ما .. يعني ماهاش الـ GGT تمام؟ إذا لو عملت الفحصين
+
+482
+00:41:12,550 --> 00:41:16,690
+مع بعض والتانين طلعوا عالين إذا أكيد المشكلة في
+
+483
+00:41:16,690 --> 00:41:20,890
+الكبد وفي القناة الصفرية لو عملت الفحصين مع بعض
+
+484
+00:41:20,890 --> 00:41:26,630
+والـ ALB كان عالي والـ GGT كان طبيعي إذا أكيد
+
+485
+00:41:26,630 --> 00:41:30,490
+المشكلة بتكون في الـ bone في العظم تمام؟
+
+486
+00:41:32,760 --> 00:41:35,900
+الـ «Say for enzyme activity» بدنا نشوف الطرق
+
+487
+00:41:35,900 --> 00:41:39,940
+المستخدمة لقياس الـ enzyme كمان يا جماعة كتاتنا
+
+488
+00:41:39,940 --> 00:41:46,440
+اللي بتفحص الـ GGT برضه colorimetric reaction زي و
+
+489
+00:41:46,440 --> 00:41:50,100
+زي فحص الـ ALB بالظبط عشان هيك لما نرجع الجامعة
+
+490
+00:41:50,100 --> 00:41:54,980
+هنشتغل واحد منهمهنشتغل يا ALP يا GGT، بس اللي
+
+491
+00:41:54,980 --> 00:41:59,280
+متوفر عندنا في الجامعة الـ ALP، تمام؟ بس هذا ما
+
+492
+00:41:59,280 --> 00:42:02,400
+بيمنع أن نشوف قليلة التفاعل كيف قليلة التفاعل،
+
+493
+00:42:02,400 --> 00:42:06,200
+انتبهوا على الصندوق الأزرق هلجت الـ Serum تبع ال
+
+494
+00:42:06,200 --> 00:42:09,940
+patient بيكون فيه الـ GGT، بيكون فيه الـ enzyme،
+
+495
+00:42:09,940 --> 00:42:14,280
+تمام؟ و أنا بدي أفحص ال activity تبعتهاهل جيت الـ
+
+496
+00:42:14,280 --> 00:42:19,440
+reaction بيكون فيه الـ substrate اللي هيكسرها الـ
+
+497
+00:42:19,440 --> 00:42:25,200
+enzyme الـ substrate هي الـ L-Gamma-Glutamyl-B
+
+498
+00:42:25,200 --> 00:42:32,640
+-Nitro-Analyte زائد لـGlycyl-Glycineهذه كلها الـ
+
+499
+00:42:32,640 --> 00:42:37,140
+substrate موجودة في الـ reagent هيشتغل عليها الـ
+
+500
+00:42:37,140 --> 00:42:41,680
+enzyme اللي موجود في الـ serum ومحصلة التفاعل
+
+501
+00:42:41,680 --> 00:42:48,280
+هيعطيني مادة اسمها الـ B-Nitroaniline و الـ Gamma
+
+502
+00:42:48,280 --> 00:42:55,350
+Glutamyl Glycylglycineإذا محصلة التفاعل اعطاء مادة
+
+503
+00:42:55,350 --> 00:43:01,470
+ملونة الـ B-Nitroaniline وشدة اللون اللي اتكونها
+
+504
+00:43:01,470 --> 00:43:06,790
+نتيجة محصلة التفاعل هتتناسب تناسب ترضي مع نشاط الـ
+
+505
+00:43:06,790 --> 00:43:12,030
+enzyme في العينة ومادة الـ B-Nitroaniline هنقرأها
+
+506
+00:43:12,030 --> 00:43:18,020
+على wavelength 405 نانومترالـ Reference Range عند
+
+507
+00:43:18,020 --> 00:43:23,120
+المال من 6 لـ 45 International Unit Per Liter عند
+
+508
+00:43:23,120 --> 00:43:28,260
+الفمال من 5 ل 30 International Unit Per Liter إذا
+
+509
+00:43:28,260 --> 00:43:31,540
+المادة التفاعل إن السيران موجود في الإنزاين
+
+510
+00:43:31,540 --> 00:43:35,640
+والـreagent فيه الـsubstrateلما بحطهم على بعض الـ
+
+511
+00:43:35,640 --> 00:43:39,620
+enzyme هيكسّر ال substrate محصلة التفاعل مادة
+
+512
+00:43:39,620 --> 00:43:43,940
+ملونة احنا بنجيس هذه المادة على wavelength معينة
+
+513
+00:43:43,940 --> 00:43:48,160
+وشدة اللون هتتناسب تناسب تردي مع ال activity تبعت
+
+514
+00:43:48,160 --> 00:43:54,240
+ال enzyme وبهيك بنكون خلصنا chapter liver function
+
+515
+00:43:54,240 --> 00:43:55,940
+test ويعطيكم ألف عافية
+
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/SjaAdCYcBak_postprocess.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/SjaAdCYcBak_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..e02dc62b5b3107cb7f465497c8b8a4a497acce64
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/SjaAdCYcBak_postprocess.srt
@@ -0,0 +1,1784 @@
+1
+00:00:00,590 --> 00:00:05,710
+مبدأ شغل الـ KET بكل بساطة Endymetic Method بتروح
+
+2
+00:00:05,710 --> 00:00:09,630
+تجيبي عينة المريض Serum أو البلازمة بيكون فيها
+
+3
+00:00:09,630 --> 00:00:13,450
+الدهون التلاتية إذاً الـ Triglycerides بيكون موجود
+
+4
+00:00:13,450 --> 00:00:18,030
+في الـ Serum أو البلازمة تبع المريض وبتروح تجيبي
+
+5
+00:00:18,030 --> 00:00:25,100
+الـ Reagent اللي موجود في KETفي الـKit الخاص بفحث
+
+6
+00:00:25,100 --> 00:00:29,120
+الـ Triglyceride بتجيب الـ Reagent الـ Reagent
+
+7
+00:00:29,120 --> 00:00:34,620
+بيكون عبارة عن انزيمات لما بنخلط، بنضيف الـ
+
+8
+00:00:34,620 --> 00:00:40,800
+Reagent على عينة المريض بيحدث هناك تفاعل ما بين
+
+9
+00:00:40,800 --> 00:00:44,880
+الانزيمات الموجودة في الـ Reagent وما بين الـ
+
+10
+00:00:44,880 --> 00:00:49,080
+Triglycerides اللي موجود في الـ Serum محصلة
+
+11
+00:00:49,080 --> 00:00:55,830
+التفاعل نحصل على لونشدّت اللون تتناسب تناسط طردي
+
+12
+00:00:55,830 --> 00:01:01,070
+مع تركيز للـ Triglycerides اللي موجود في الـ Serum
+
+13
+00:01:01,070 --> 00:01:07,030
+يعني نتيجة التفاعل لو نتج لون غامق هذا دليل إن
+
+14
+00:01:07,030 --> 00:01:12,010
+الدهون التلاتية تركيزها عالي في العينة لو نتج لون
+
+15
+00:01:12,010 --> 00:01:16,450
+فاتح معناه إن الدهون التلاتية تركيزها طبيعي في
+
+16
+00:01:16,450 --> 00:01:21,950
+العينة إذا التفاعل كالقاتيالـ Triglycerides اللي
+
+17
+00:01:21,950 --> 00:01:27,350
+موجود في عينة المريض لايبوبروتين ليباس هذا عبارة
+
+18
+00:01:27,350 --> 00:01:32,090
+عن انزايم موجود في الرياجين لما بندير الرياجين على
+
+19
+00:01:32,090 --> 00:01:36,030
+عينة المريض هذا الانزايم بيشتغل على الـ
+
+20
+00:01:36,030 --> 00:01:40,610
+Triglyceride وبيكسرها بيعطيني Glycerol و 3 fatty
+
+21
+00:01:40,610 --> 00:01:47,000
+acidالـGlycerol في وجود الـATP ووجود إنزايم آخر
+
+22
+00:01:47,000 --> 00:01:52,020
+موجود في الـreagent اسمه الـGlycerol Kinase
+
+23
+00:01:52,020 --> 00:01:56,800
+هيعطيني مادة لـGlycerol تلاتة فوسفات زائد ADP
+
+24
+00:01:56,800 --> 00:02:01,700
+الـGlycerol تلاتة فوسفات في وجود إنزايم آخر موجود
+
+25
+00:02:01,700 --> 00:02:06,360
+في الـreagent اسمه Glycerol Phosphate Oxidase
+
+26
+00:02:06,360 --> 00:02:10,380
+هيعطيني مادة اسمها الـDihydroxy
+
+27
+00:02:12,230 --> 00:02:16,330
+acetone phosphate زائد hydrogen peroxide الـ
+
+28
+00:02:16,330 --> 00:02:20,090
+hydrogen peroxide لما يتفاعل مع مادة موجودة في الـ
+
+29
+00:02:20,090 --> 00:02:24,410
+reagent الأربع أمينوفينازون في وجود الـ peroxidase
+
+30
+00:02:24,410 --> 00:02:28,150
+enzyme برضه موجود في الـ reagent في الآخر هيعطوني
+
+31
+00:02:28,150 --> 00:02:34,630
+مادة اسمها liquinonimine هذه مادة هي الـ colored
+
+32
+00:02:34,630 --> 00:02:41,710
+compoundالمُركّب الملون الناتج نتيجة تفاعل الـ
+
+33
+00:02:41,710 --> 00:02:44,790
+Reagent مع الدغون التلاتية الموجودة في الـ Serum
+
+34
+00:02:44,790 --> 00:02:49,210
+تبع المريض وطبعا هذا اللون بنقيسه احنا على جهاز
+
+35
+00:02:49,210 --> 00:02:53,890
+الـ Spectrophotometer، تمام؟ إذا نفس مبدأ عمل
+
+36
+00:02:53,890 --> 00:02:58,410
+السكر، فحص السكر وفحص الـ Total Protein وفحص
+
+37
+00:02:58,410 --> 00:03:02,470
+الألبومين كانت كلها عبارة عن Color، ينتج عندنا
+
+38
+00:03:02,470 --> 00:03:08,620
+Color ونقيسه على الـ Spectraالـ procedure لالفحص
+
+39
+00:03:08,620 --> 00:03:13,320
+بتجيبي تلت أنبيب بلاستيك تيوب بتعمليلهم label
+
+40
+00:03:13,320 --> 00:03:17,040
+تكتبي على الأولى plank التانية standard التالتة ال
+
+41
+00:03:17,040 --> 00:03:20,800
+patient standard بتجيبي ال reagent A اللي هو ال
+
+42
+00:03:20,800 --> 00:03:25,140
+reagent تبع الـ triglyceride test وبتحطي على كل
+
+43
+00:03:25,140 --> 00:03:30,300
+تيوب واحد انقل يعني الف microliter ال kit تبع
+
+44
+00:03:30,300 --> 00:03:34,020
+الدهون التلاتية بيقول فيه standard هذا ال standard
+
+45
+00:03:34,550 --> 00:03:40,310
+عبارة عن دهون تلاتية تمام؟ ويلها تركيز معين يعني
+
+46
+00:03:40,310 --> 00:03:43,570
+تركيز الدهون التلاتية الموجودة في الـ Standard
+
+47
+00:03:43,570 --> 00:03:48,630
+بتكون معلومة وبتكون مكتوبة على علبة الـ Standard
+
+48
+00:03:48,630 --> 00:03:52,790
+نفسها تفتح الـ Standard تاخد منه 10 مايكرون
+
+49
+00:03:52,790 --> 00:03:57,590
+وبتحطيها فوق الـ 1 ML داخل انبوبة الـ Standard
+
+50
+00:03:57,590 --> 00:04:02,390
+وتعمل ميكس منيحةو بتجيب السيرام أو البلازمة تبعت
+
+51
+00:04:02,390 --> 00:04:06,430
+ال patient sample تاخد منها 10 مايكرون و بتحطيها
+
+52
+00:04:06,430 --> 00:04:10,630
+في انبوبة ال sample و بتجيبي 10 مايكروليتر من ال
+
+53
+00:04:10,630 --> 00:04:14,390
+distilled water و بتحطيها في انبوبة ال blank و
+
+54
+00:04:14,390 --> 00:04:18,570
+تعملي mix منيح و incubation 10 دقائق at room
+
+55
+00:04:18,570 --> 00:04:23,330
+temperature أو ممكن تاخد الأنابيب و تحطيها في ال
+
+56
+00:04:23,330 --> 00:04:29,530
+water bath لمدة 5 دقائقبعدين بتقرأي هال جيت بتجيب
+
+57
+00:04:29,530 --> 00:04:32,970
+ال blank و بتسفر ال spectrophotometer على ال blank
+
+58
+00:04:32,970 --> 00:04:38,190
+بعدين بتحطي انبوبة ال standard بتحطيها ب QVIT
+
+59
+00:04:38,190 --> 00:04:42,390
+السائل اللي جوا انبوبة ال standard بتحطيها في ال
+
+60
+00:04:42,390 --> 00:04:47,210
+QVIT و بتقرايها إذا إحنا أخدنا ال absorbance لل
+
+61
+00:04:47,210 --> 00:04:53,250
+standardبعدين بتجيبى cuvette أخرى بتحط فيها مكونات
+
+62
+00:04:53,250 --> 00:04:58,010
+ال sample و بتقرأى انبوبة ال sample و بتاخدى
+
+63
+00:04:58,010 --> 00:05:03,850
+absorbance لل sample و التفاعل بيضلوا stable لمدة
+
+64
+00:05:03,850 --> 00:05:08,830
+ساعة إذا أنا حصلت على ال absorbance لل standard و
+
+65
+00:05:08,830 --> 00:05:12,570
+absorbance لل sample كيف بدي أطلّر تركيز الدهون
+
+66
+00:05:12,570 --> 00:05:18,370
+التلاتية بطبق برزلوالـ Concentration للـ
+
+67
+00:05:18,370 --> 00:05:24,010
+Triglyceride في عينة المريض يساوي الـ Absorbance
+
+68
+00:05:25,640 --> 00:05:30,980
+تبع الـ Patient Sample على الـ Absorbance للـ
+
+69
+00:05:30,980 --> 00:05:35,560
+Standard درب الـ Concentration للـ Standard الـ
+
+70
+00:05:35,560 --> 00:05:38,340
+Absorbance للـ Patient Sample معروف والـ
+
+71
+00:05:38,340 --> 00:05:42,000
+Absorbance للـ Standard معروف والـ Concentration
+
+72
+00:05:42,000 --> 00:05:46,140
+للـ Standard معروف إذا بقدر أعرف الـ Concentration
+
+73
+00:05:46,660 --> 00:05:50,620
+للدهون التلاتية في ال patient sample و الوحدة
+
+74
+00:05:50,620 --> 00:05:56,240
+بالmilligram per deciliter و ال normal range للـ
+
+75
+00:05:56,240 --> 00:06:02,900
+triglyceride عند الإنسان الطبيعي يعني أقل من 200
+
+76
+00:06:02,900 --> 00:06:07,240
+milligram per deciliter لازم الدهون التلاتية تكون
+
+77
+00:06:07,240 --> 00:06:11,580
+أقل من 200 milligram per deciliter في العينة ال
+
+78
+00:06:11,580 --> 00:06:24,540
+normal تمام؟ ال cholesterolالكلسترول هو
+
+79
+00:06:24,540 --> 00:06:31,400
+نوع من أنواع الدهون اللي موجودة في بلازمة الدم
+
+80
+00:06:31,400 --> 00:06:36,540
+بشكل أساسي إذا الـ Triglycerides الدهون التلاتية
+
+81
+00:06:36,540 --> 00:06:43,060
+والكلسترول هذه الدهون أساسية موجودة في بلازمة الدم
+
+82
+00:06:43,710 --> 00:06:47,010
+service mainly important physiological functions
+
+83
+00:06:47,010 --> 00:06:51,330
+including الكوليسترول إلو تلت وظائف أساسية في
+
+84
+00:06:51,330 --> 00:06:56,630
+الجسم يدخل الكوليسترول في تصنيع العصارة السفراوية
+
+85
+00:06:56,630 --> 00:07:02,330
+synthesis of bile acid ويدخل في تصنيع ال steroid
+
+86
+00:07:02,330 --> 00:07:06,870
+hormones أيضا يدخل في تركيب ال cell membrane
+
+87
+00:07:07,440 --> 00:07:13,560
+الكلسترول يدخل في تركيب غشاء الكثير من الخلايا
+
+88
+00:07:13,560 --> 00:07:19,580
+الكثير من الخلايا في الجسم عشان تنبنى لازم
+
+89
+00:07:19,580 --> 00:07:24,580
+يتكونلها مثلا الغشاء هذا الغشاء تركيبته الأساسية
+
+90
+00:07:24,580 --> 00:07:28,800
+بتكون كلسترول يعني بيدخل في تركيب الغشاء هو
+
+91
+00:07:28,800 --> 00:07:36,830
+الكلستروليعني الكوليسترول هو مكوّن أساسي ضمن
+
+92
+00:07:36,830 --> 00:07:41,330
+مكونات الـ cell membrane كوليسترول أيضًا يظهر
+
+93
+00:07:41,330 --> 00:07:45,290
+يتعامل بـ atherosclerosis هذا التقاط الكوليسترول
+
+94
+00:07:45,290 --> 00:07:49,230
+هو واحد من تجارب العمليات العامة التي تستخدمها
+
+95
+00:07:49,230 --> 00:07:55,760
+اليومالكوليسترول كتير ارتفاعه مرتبط بحدوث تسلب
+
+96
+00:07:55,760 --> 00:08:01,720
+الشرين لأنه الفائض من الكوليسترول والكوليسترول
+
+97
+00:08:01,720 --> 00:08:06,060
+الذائد عن الحاجة بيروحه هو مترسب في الأوعية
+
+98
+00:08:06,060 --> 00:08:11,020
+والشرين وبالتالي عامل تسلب شرين عشان هيك قياس
+
+99
+00:08:11,020 --> 00:08:16,380
+مستوى الكوليسترول في الدم واحد من الفحوصات الشائعة
+
+100
+00:08:16,380 --> 00:08:18,140
+الروتونية حاليا
+
+101
+00:08:20,710 --> 00:08:24,790
+لو إجاني شخص بده يعمل فحص الـ Cholesterol Test
+
+102
+00:08:24,790 --> 00:08:29,310
+تمام، إيش نوع العينة؟ يا Serum، يا Plasma الـ
+
+103
+00:08:29,310 --> 00:08:33,590
+Anticoagulant المسموح فيها إيديتا أو هيبارين أي
+
+104
+00:08:33,590 --> 00:08:38,430
+Anticoagulant غير الإيديتا أو الهيبارين مرفوضة زي
+
+105
+00:08:38,430 --> 00:08:43,330
+الـ Fluoride، السترات، الأجزالات، هذه كلها مرفوضة
+
+106
+00:08:43,330 --> 00:08:50,830
+وليش مرفوضة؟ لنفس السبب فيفحص الـ Triglyceride
+
+107
+00:08:50,830 --> 00:08:55,290
+حكينا إن لو استخدمت هذه الـ Anticoagulant هتعمل
+
+108
+00:08:55,290 --> 00:09:00,190
+shifting للـ water اللي موجود في ال RBCs ويطلعوا
+
+109
+00:09:00,190 --> 00:09:05,150
+على البلازمة وبالتالي هتخفف مكونات البلازمة يعني
+
+110
+00:09:05,150 --> 00:09:08,970
+هتخفف الكوليسترول وبالتالي هيجي المستوى
+
+111
+00:09:08,970 --> 00:09:14,550
+الكوليسترول بشكل خاطرلـ Storage and Stability ممكن
+
+112
+00:09:14,550 --> 00:09:18,790
+السيرم أو البلازم أخذنهم سبع أيام في التلاجة أو
+
+113
+00:09:18,790 --> 00:09:25,030
+تلت أشهر فيه للـ Freezerبرضه مادة عمل الـ kit
+
+114
+00:09:25,030 --> 00:09:29,250
+enzymatic reaction يعني الـ reagent الخاص
+
+115
+00:09:29,250 --> 00:09:34,330
+بالكلسترول بيكون عبارة عن enzymes عن مجموعة من
+
+116
+00:09:34,330 --> 00:09:39,590
+الانزيمات الكلام اللي فوق بالـ slide ملخصه ال
+
+117
+00:09:39,590 --> 00:09:44,050
+chart اللي تحت خلينا نتبع على ال chart اللي تحتهل
+
+118
+00:09:44,050 --> 00:09:48,570
+جيت الـ Serum أو البلازمة عيّنة المريض بيكون فيها
+
+119
+00:09:48,570 --> 00:09:54,130
+الكوليسترول بس يا جماعة ملاحظة أن الكوليسترول ما
+
+120
+00:09:54,130 --> 00:10:00,550
+بيكون موجود بشكل إفري في البلازمة تبع الدم عند
+
+121
+00:10:00,550 --> 00:10:06,270
+الإنسانالكلسترول ما بيكون free، بيكون مربوط بـ
+
+122
+00:10:06,270 --> 00:10:11,650
+Fatty Acid بأحماض دهنية بواسطة رابطة الـ E-sperb
+
+123
+00:10:11,650 --> 00:10:15,570
+bond يعني الكوليسترول اللي موجود في الـ Serum تبعي
+
+124
+00:10:16,480 --> 00:10:21,980
+أو في البلازمة تبعتي بيكون شكله كليسترول إيسترز
+
+125
+00:10:21,980 --> 00:10:27,820
+يعني كليسترول مربوط بأحماض دهنية بواسطة Easter
+
+126
+00:10:27,820 --> 00:10:31,700
+bond إذا السيرام أو البلازمة تبعت المريض فيها
+
+127
+00:10:31,700 --> 00:10:38,510
+كليسترول إيسترفي وجود الميّه والكليسترول استيريز
+
+128
+00:10:38,510 --> 00:10:42,710
+انزاي موجود في الـ reagent هيشتغل على الكليسترول
+
+129
+00:10:42,710 --> 00:10:48,630
+Easter ويكسّر الكليسترول Easter وبالتالي هيتحرر
+
+130
+00:10:48,630 --> 00:10:53,610
+الكليسترول وينفك عن ال fatty acid اللي كانت رطّة
+
+131
+00:10:53,610 --> 00:10:58,590
+فيههيجي الكوليسترول يربط في الـ Oxygen اللي جاي من
+
+132
+00:10:58,590 --> 00:11:02,910
+الهواء الجوي، في وجود انظيم اسمه كوليسترول
+
+133
+00:11:02,910 --> 00:11:06,810
+أكسيدازي موجود في الـreagent، هيعطيني مركب اسمه
+
+134
+00:11:06,810 --> 00:11:10,830
+كوليسترول تلاتة one زائد hydrogen peroxide،
+
+135
+00:11:10,830 --> 00:11:14,970
+hydrogen peroxide مع الhydroxybenzoate
+
+136
+00:11:17,260 --> 00:11:24,120
+والاربعة أمينو تايدريدين هذه كلها مواد موجودة في
+
+137
+00:11:24,120 --> 00:11:28,520
+الـreagent في وجود البروكسيدايز انزايم محصلة
+
+138
+00:11:28,520 --> 00:11:34,340
+الـreaction هيعطيهم اللون الأحمر وأربع جزيئات ميّه
+
+139
+00:11:34,340 --> 00:11:42,040
+إذن اتحادأو تفاعل الكوليسترول Easter اللي موجود في
+
+140
+00:11:42,040 --> 00:11:46,200
+الـ Serum مع الـ Reagent محصلة التفاعل هيعطيني
+
+141
+00:11:46,200 --> 00:11:50,780
+مادة املونة ولون التفاعل هيكون أحمر أول ما شوف
+
+142
+00:11:50,780 --> 00:11:54,340
+اللون الأحمر معناه حدث هناك reaction ما بين
+
+143
+00:11:54,340 --> 00:11:57,060
+الكوليسترول الموجود في عينة المريض وما بين الـ
+
+144
+00:11:57,060 --> 00:12:01,120
+Reagent وشدت اللون تتناسب تناسب تردي مع تركيز
+
+145
+00:12:01,120 --> 00:12:07,810
+الكوليسترول اللي موجود في العينة تمام؟نفس مبدأ شغل
+
+146
+00:12:07,810 --> 00:12:11,450
+كتات لـ Triglyceride والسكر والـ Total Protein
+
+147
+00:12:11,450 --> 00:12:17,300
+والألبماالـ procedure نفس شغل لـ Triglyceride
+
+148
+00:12:17,300 --> 00:12:22,300
+بتجيبي تلتة أنبيب بتعملي blank بتعملي label تكتبي
+
+149
+00:12:22,300 --> 00:12:25,320
+على الأنبوبة الأولى blank تانية standard تالتة
+
+150
+00:12:25,320 --> 00:12:28,840
+sample بتجيبي الـ reagent الخاص بالكوليسترول بتحطي
+
+151
+00:12:28,840 --> 00:12:33,100
+على كل tube واحد أمقل بتجيبي ال standard اللي
+
+152
+00:12:33,100 --> 00:12:37,460
+جواته كوليسترول واللي تركيزه معلوم تاخد منه عشرة
+
+153
+00:12:37,460 --> 00:12:41,360
+micron بيكون في ال kit تبع الكوليسترول وبتحطيه في
+
+154
+00:12:41,360 --> 00:12:45,010
+أنبوبة ال standard وبتعملي mixو بتجيب ال patient
+
+155
+00:12:45,010 --> 00:12:48,590
+sample serum أو البلازمة بتاخد منها 10 مايكرون و
+
+156
+00:12:48,590 --> 00:12:52,810
+بتحطيها في انبوبة ال sample و بتجيب 10 مايكرون من
+
+157
+00:12:52,810 --> 00:12:57,040
+ال distilled water و بتحطيها على ال blankتعمل ميكس
+
+158
+00:12:57,040 --> 00:13:00,720
+منيح للانابيب وincubation عشرين دقيقة الـ room
+
+159
+00:13:00,720 --> 00:13:05,240
+temperature أو ممكن تاخد الانابيب تحطيها على الـ
+
+160
+00:13:05,240 --> 00:13:09,520
+water bath لمدة عشر دقائق بعدين بتسفر الجهاز على
+
+161
+00:13:09,520 --> 00:13:13,740
+خمسمية نانو متر بتسفري على الـ plank تضبط ال
+
+162
+00:13:13,740 --> 00:13:17,620
+wavelength على خمسمية نانو متر و بتحطيها ال gate
+
+163
+00:13:17,620 --> 00:13:23,170
+في الكيوفت مكونات انبوبة الـ standardتاخد الـ
+
+164
+00:13:23,170 --> 00:13:26,790
+Absorbance للـ Standard و بعدين الـ Absorbance للـ
+
+165
+00:13:26,790 --> 00:13:31,270
+Sample و بعدين بتطبق بيريز لا عشان تحس بتركيز
+
+166
+00:13:31,270 --> 00:13:36,730
+الكوليسترول في عينة ال patient و الوحدة هتطلع بال
+
+167
+00:13:36,730 --> 00:13:40,970
+milligram per deciliter أيضا ال normal range
+
+168
+00:13:40,970 --> 00:13:45,530
+للكوليسترول في الجسم لازم يكون أقل من 200
+
+169
+00:13:45,530 --> 00:13:50,440
+milligram per deciliter و بدناش ننسىإنه ال normal
+
+170
+00:13:50,440 --> 00:13:55,180
+range من مختبر لمختبر بيكون مختلف حسب ال kit و حسب
+
+171
+00:13:55,180 --> 00:14:01,420
+الشركة اللي بتصنع ال kit تمام؟الـ HDL الـ high
+
+172
+00:14:01,420 --> 00:14:05,840
+density lipoprotein is a fraction of plasma
+
+173
+00:14:05,840 --> 00:14:11,680
+lipoprotein وهو نوع من أنواع نواقل الدهون وبشكل
+
+174
+00:14:11,680 --> 00:14:17,160
+أساس اتفاجنا أنه بينجل الكلسترول هل بينجل دهون
+
+175
+00:14:17,160 --> 00:14:23,590
+تلاتية triglyceride نعم ولكن بكميات قليلةالـ HDL
+
+176
+00:14:23,590 --> 00:14:29,290
+يا جماعة بيسموه الـ Good Libo Protein الناقل الجيد
+
+177
+00:14:29,290 --> 00:14:35,010
+للكلسترول بينما الـ LDL الـ Low Density Libo
+
+178
+00:14:35,010 --> 00:14:40,730
+Protein برضه هذا ناقل للكلسترول لكن الـ LDL بيسموه
+
+179
+00:14:40,730 --> 00:14:47,170
+الـ Bad Cholesterol الناقل السيء للكلسترول ليش؟
+
+180
+00:14:47,170 --> 00:14:53,010
+ليش الـ HDL بيسموه Good والـ LDL بيسموه Bad؟لأن
+
+181
+00:14:53,010 --> 00:14:59,950
+الـ LDL بياخد الكوليسترول اللي أكلناه يعني اللي
+
+182
+00:14:59,950 --> 00:15:04,090
+كان مصدره من الـ diet الأكل وبياخد الكوليسترول
+
+183
+00:15:04,090 --> 00:15:09,390
+اللي اتصنع جواة الجسم، داخل الكبت، داخل الـ liver
+
+184
+00:15:09,390 --> 00:15:15,530
+بياخد الكوليسترول وبيبدأ يوزع فيه على الـ tissue
+
+185
+00:15:15,530 --> 00:15:23,340
+والأنسجة اللي بتحتاج إلى الكوليسترولتتكون عشان
+
+186
+00:15:23,340 --> 00:15:29,480
+يعني العمليات الحيوية المختلفة، تمام؟ إذن الـ LDL
+
+187
+00:15:29,480 --> 00:15:38,780
+بيوزع الكوليسترول من الكبد ومن الدم لأنحاء التشوق
+
+188
+00:15:38,780 --> 00:15:43,860
+المختلفة ولأنسجة الجسم المختلفة والخلايا المختلفة
+
+189
+00:15:43,860 --> 00:15:49,960
+اللي بيحاجة لكوليسترولبينما الـ HDL يا جماعة
+
+190
+00:15:49,960 --> 00:15:57,360
+بيشتغل عكس الـ LDL بيروح على التشوف والخلايا بياخد
+
+191
+00:15:57,360 --> 00:16:02,280
+الفائض من الكوليسترول هالجيت الخلية أخدت حاجتها من
+
+192
+00:16:02,280 --> 00:16:07,220
+الكوليسترول الفائض لو دلوا متراكم على الخلية أو
+
+193
+00:16:07,220 --> 00:16:13,020
+على النسيج هيخربهاوبالتالي أي فائض من الكوليسترول
+
+194
+00:16:13,020 --> 00:16:18,000
+داخل الخلايا بيجي الـ HDL بياخد هذا الفائض من
+
+195
+00:16:18,000 --> 00:16:23,860
+الكوليسترول و بيحمله و بيضله يمشي و برجع على الكبد
+
+196
+00:16:23,860 --> 00:16:28,720
+بيوديه على الكبد عشان الكبد يتصرف في الفائض من
+
+197
+00:16:28,720 --> 00:16:34,900
+الكوليسترول و يطلعه بطرق مختلفة من الجسم، تمام؟إذن
+
+198
+00:16:34,900 --> 00:16:39,800
+بدنا نفهم إن الـ LDL الكوليسترول هذا الـ Low
+
+199
+00:16:39,800 --> 00:16:44,940
+Density Lipoprotein هذا اللي بيوزع الكوليسترول من
+
+200
+00:16:44,940 --> 00:16:50,840
+مكان التصنيع من الكبد لأنسجة الجسم و للخلايا اللي
+
+201
+00:16:50,840 --> 00:16:57,160
+بدها الكوليسترول بس الـ HDL هذا الـ Good اللي كويس
+
+202
+00:16:57,160 --> 00:17:03,020
+فيه إنه بيروح على الخلايابيحمل فائد الكوليسترول،
+
+203
+00:17:03,020 --> 00:17:07,740
+الفائد عن حاجتها، بياخده، بيلتقطه، و بيمشي بشكل
+
+204
+00:17:07,740 --> 00:17:12,740
+reverse عكسي لفوق، لحد ما يصلّى الكبد، و بيودّي
+
+205
+00:17:12,740 --> 00:17:18,530
+الفائد لكبد، عشان الكبد يتصرف بهذا الفائد، تمام؟it
+
+206
+00:17:18,530 --> 00:17:23,410
+is composed of تركيبة الـ HDL قولنا عامل زي الكورة
+
+207
+00:17:23,410 --> 00:17:28,290
+من برا عبارة عن البروتين هو أصلا عبارة عن البروتين
+
+208
+00:17:28,290 --> 00:17:34,550
+الماقل 50% من تركيبته البروتين وحكينا برضه من برا
+
+209
+00:17:34,550 --> 00:17:40,330
+إغشاءه فيه phospholipid و 25% من تركيبه فيه
+
+210
+00:17:40,330 --> 00:17:45,300
+phospholipidو جوه إذا حكينا التركيبة الخارجية
+
+211
+00:17:45,300 --> 00:17:50,140
+protein و phospholipid و جوه بيشيل الكوليسترول
+
+212
+00:17:50,140 --> 00:17:54,420
+اللي بده يعني ياخده من الأنسجة و الخلايا و يوديه
+
+213
+00:17:54,420 --> 00:17:59,560
+للـ liver عشرين في المية من الكوليسترول يتم وضعه
+
+214
+00:17:59,560 --> 00:18:06,570
+بداخل هذا ال protein و نقله إلى الكبدو 5% بيحمل
+
+215
+00:18:06,570 --> 00:18:10,210
+الـ triglyceride اتفاجنا هو بيحمل دهون تلاتية ولكن
+
+216
+00:18:10,210 --> 00:18:14,630
+بنسبة قليلة إنما بشكل أساسي هو ناقل للكوليسترول
+
+217
+00:18:14,630 --> 00:18:20,310
+evidence suggest that كتير أدلة جالت إنه الـ high
+
+218
+00:18:20,310 --> 00:18:24,590
+density lipoprotein cholesterol هذا الناقل is a
+
+219
+00:18:24,590 --> 00:18:30,420
+primary coronary heart disease risk factorحكينا إن
+
+220
+00:18:30,420 --> 00:18:35,080
+الإنسان الطبيعي الـ HDL لازم يكون أعلى من 60
+
+221
+00:18:35,080 --> 00:18:41,220
+milligram per deciliter لو فحصته و لجيته أقل من 60
+
+222
+00:18:41,220 --> 00:18:46,140
+milligram per deciliter هذا risk factor إن الشخص
+
+223
+00:18:46,140 --> 00:18:50,540
+سينصاب بـ coronary heart disease لأنه تخيلوا
+
+224
+00:18:50,540 --> 00:18:55,500
+الموضوع لو الـ HDL تركزه قليل في الجسم إيش هيصير
+
+225
+00:18:55,500 --> 00:18:59,080
+في الكوليسترول اللي موجود في الخلايا؟هيترسّب على
+
+226
+00:18:59,080 --> 00:19:05,650
+تشغيل الخلايا مش هيلاقي الـ HDL الناقلمش هيكون
+
+227
+00:19:05,650 --> 00:19:11,450
+موجود وحكينا وظيفته إنه ياخد الفائض عن حاجة الخلية
+
+228
+00:19:11,450 --> 00:19:16,190
+ويرجعه للكبد طيب لو مش موجود الـ HDL إيش هيصير في
+
+229
+00:19:16,190 --> 00:19:20,310
+الكلسترول؟ مش هيلاقي مين يشيله ويطلعه على ال liver
+
+230
+00:19:20,310 --> 00:19:25,470
+فهيضله مترسب على الخلايا ويخرّب الخلايا ويعمل
+
+231
+00:19:25,470 --> 00:19:29,930
+أمراض في الشراين والأورده تمام؟ لأن الكلسترول
+
+232
+00:19:29,930 --> 00:19:31,630
+هيكون مترسب فيها
+
+233
+00:19:34,330 --> 00:19:39,690
+الـ Analysis Methods طرق قياس الـ HDL كيف بنقيص
+
+234
+00:19:39,690 --> 00:19:44,490
+الـ HDL أول طريقة بالـ Ultra Centrifugation ما
+
+235
+00:19:44,490 --> 00:19:50,850
+بيستخدموها اكتر طبعا الـ Liboprotein لواق الدهون
+
+236
+00:19:50,850 --> 00:19:56,460
+أربعةالـ Kylomicron الـ HDL والـ LDL والـ VLDL
+
+237
+00:19:56,460 --> 00:20:00,820
+هدولا كلهم بيكونوا موجودين في البلازمة تبع الإنسان
+
+238
+00:20:00,820 --> 00:20:04,980
+أو في السيرام تاخد عينة البلازمة أو السيرام
+
+239
+00:20:04,980 --> 00:20:10,740
+وبتحطيها في جهاز centrifuge اسمه Ultra Centrifuge
+
+240
+00:20:10,740 --> 00:20:18,940
+هذا الجهاز هيفصل العينة إلى أربع طبقات تمام؟طبقة
+
+241
+00:20:18,940 --> 00:20:24,100
+هيكون موجود فيها الـ HDL وطبقة هيكون فيها الـ LDL
+
+242
+00:20:24,100 --> 00:20:28,780
+وطبقة هيكون فيها الـ VLDL وطبقة هيكون فيها
+
+243
+00:20:28,780 --> 00:20:33,860
+كايدومايكرون هتاخدوا التفصيل أكتر مع الدكتور مازن
+
+244
+00:20:33,860 --> 00:20:38,420
+بس احنا الفكرة، فكرة الفحص إنه في جهاز بيفصل
+
+245
+00:20:38,420 --> 00:20:43,820
+الـLiboproteins الأربعة بيفصلهم عن بعض بيفصل
+
+246
+00:20:43,820 --> 00:20:49,310
+الـHDL وLDL وVLDL وكايدومايكرون عن بعضالفصل بناء
+
+247
+00:20:49,310 --> 00:20:55,870
+على الـ density بناء على مدى كثافة هذا الناقل طبعا
+
+248
+00:20:55,870 --> 00:21:01,690
+الـ HDL هو أعلى واحد من حيث الـ density من اسمه
+
+249
+00:21:01,690 --> 00:21:06,010
+اسمه high density lipoproteinواللي بتكون كثافته
+
+250
+00:21:06,010 --> 00:21:11,510
+أكتر بيكون محتوى من البروتينات أكتر احنا حكينا 50%
+
+251
+00:21:11,510 --> 00:21:16,630
+من تركيبة الـ HDL عبارة عن البروتينات يعني أعلى
+
+252
+00:21:16,630 --> 00:21:24,070
+واحد في الكثافة الـ HDL تمام؟ هيجي من وراه الـ LDL
+
+253
+00:21:24,070 --> 00:21:29,030
+الـ Low Density Liboprotein ومن وراه الـ VLDL الـ
+
+254
+00:21:29,030 --> 00:21:33,240
+Very Low Density Liboproteinمن ورا الـKylomicron
+
+255
+00:21:33,240 --> 00:21:38,460
+الـKylomicron جاله أنها أقل واحدة من حيث الكثافة
+
+256
+00:21:38,460 --> 00:21:45,540
+وبالتالي محتوىها لبروتين قليل جدا، تمام؟ إذا فكرة
+
+257
+00:21:45,540 --> 00:21:49,260
+الـUltra Centrifugation مابدي أي تفصيل من اللي
+
+258
+00:21:49,260 --> 00:21:53,380
+حكيته، هتاخدوه مع الدكتور مازن، بس بدكوا تعرفوا أن
+
+259
+00:21:53,380 --> 00:21:57,840
+طريقة بتنفصل فيها الـLiboprotein نواقل الدهون عن
+
+260
+00:21:57,840 --> 00:22:04,350
+بعضها البعض،حسب كثافتها واللي تركيبه واللي محتوالي
+
+261
+00:22:04,350 --> 00:22:09,450
+بروتيني أكتر يعني الناقل اللي عنده بروتينات أكتر
+
+262
+00:22:09,450 --> 00:22:15,890
+هو معناه كثافته أعلى تمام بولي أكرا لماي جيل
+
+263
+00:22:15,890 --> 00:22:21,150
+إلكتروفوريسس هذا ان شاء الله السنة الجاية الفصل
+
+264
+00:22:21,150 --> 00:22:23,270
+التاني هناخد
+
+265
+00:22:26,740 --> 00:22:30,860
+الـ Polyacrylamide Gel Electrophoresis الفصل الجاي
+
+266
+00:22:30,860 --> 00:22:37,950
+هناخدكيف ممكن أفصل الليبو بروتين الأربعة نواق
+
+267
+00:22:37,950 --> 00:22:41,910
+الدهون الأربعة على الـ Polyacrylamide Gel هتشوفوا
+
+268
+00:22:41,910 --> 00:22:46,670
+يا جماعة الأربع بندات الـ HDL و الـ LDL و الـ VLDL
+
+269
+00:22:46,670 --> 00:22:52,250
+و الـ Kilo Micron و بقدر بعد ما أفصلهم أحسب تركيز
+
+270
+00:22:52,250 --> 00:22:57,390
+كل واحد على حدة من خلال جهاز اسمه «Densitometer»
+
+271
+00:22:57,390 --> 00:23:02,260
+هناخده بالتفصيل الفصل الجايالـ Precipitation في
+
+272
+00:23:02,260 --> 00:23:06,560
+كتات و هذه الكتات المعتمدة عندنا في المختبر ان انا
+
+273
+00:23:06,560 --> 00:23:10,680
+بفحص تركيز الـ HDL بطريقة الـ Precipitation
+
+274
+00:23:10,680 --> 00:23:16,720
+الطريقة بتعتمد على اني باضيف اني باضيف مادة على
+
+275
+00:23:16,720 --> 00:23:20,920
+الـ Serum تبع المريض هذه المادة بتعمل الـ
+
+276
+00:23:20,920 --> 00:23:28,060
+Precipitation ترثيبلكل الـ lipoprotein ما عدا الـ
+
+277
+00:23:28,060 --> 00:23:32,520
+lipoprotein اللي أنا بدي أقيصه بيظل فوق، بيظل فيه
+
+278
+00:23:32,520 --> 00:23:37,940
+الـ supernatant مثلا اليوم أنا بدي أقيص الـ HDLبحط
+
+279
+00:23:37,940 --> 00:23:43,060
+مادة بترسّب كل الـ lipoprotein تحت اللي هم الـ
+
+280
+00:23:43,060 --> 00:23:48,040
+VLDL و الـ LDL و الـ Kilomicron و بضل عندي لفوق
+
+281
+00:23:48,040 --> 00:23:52,920
+الـ HDL إذا based on the ability of various agents
+
+282
+00:23:52,920 --> 00:23:56,240
+to precipitate the selectivity of the major
+
+283
+00:23:56,240 --> 00:24:00,820
+lipoprotein fractions except HDL بضيف مادة بترسّب
+
+284
+00:24:00,820 --> 00:24:05,130
+كل الـ lipoprotein معدل الـ HDLImmunological طرق
+
+285
+00:24:05,130 --> 00:24:09,270
+مناعية احنا بنحكي نواقل الدهون اللي هي الـ
+
+286
+00:24:09,270 --> 00:24:12,030
+lipoprotein عبارة عن البروتينات عبارة عن
+
+287
+00:24:12,030 --> 00:24:16,730
+الانتيجينات فلو جبت انا antibodies مثلا هنا
+
+288
+00:24:16,730 --> 00:24:22,510
+بيحكيلك بدي اقيس ال HDL لو جبت antibodiesهذا الـ
+
+289
+00:24:22,510 --> 00:24:28,490
+Antibody مثلا جبت Antibody ضد الـ LDL وAntibody ضد
+
+290
+00:24:28,490 --> 00:24:34,170
+الـ VLDL وAntibody ضد الـ Kilomicron او اذا تمام
+
+291
+00:24:34,170 --> 00:24:39,870
+المهم Antibodies بجيبها لكل الـ lipoprotein مع هذا
+
+292
+00:24:39,870 --> 00:24:44,090
+الـ lipoprotein اللي انا بدي اقيسه بخليه free
+
+293
+00:24:44,090 --> 00:24:51,490
+باخده و بقيسه تمام؟أو العكس أروح أجيب antibody ضد
+
+294
+00:24:51,490 --> 00:24:56,050
+مثلا الـHDL اللي أنا بدي أقيسه برتبط معاه ما هو
+
+295
+00:24:56,050 --> 00:24:59,570
+الـHDL-antigen مع الـantibody بعطيني الـcomplex
+
+296
+00:24:59,570 --> 00:25:03,570
+بالإليزا بالطرق المنعية اللي أنتوا عارفينها بيتم
+
+297
+00:25:03,570 --> 00:25:08,720
+قياس تركيز الـHDLهنا إيش حاكيه إن Antibodies
+
+298
+00:25:08,720 --> 00:25:13,200
+against human lipoproteins are used to form
+
+299
+00:25:13,200 --> 00:25:17,540
+antigen-antibody complexes with LDL, VLDL and
+
+300
+00:25:17,540 --> 00:25:22,480
+chylomicron يعني جاب Antibody ضد الليبوبروتين هذه
+
+301
+00:25:22,480 --> 00:25:28,550
+التلاتةin a way that only فقط الـ HDL الـ
+
+302
+00:25:28,550 --> 00:25:33,550
+selectivity determined فقط الـ HDL بيضلوا free و
+
+303
+00:25:33,550 --> 00:25:39,030
+بقيسوا بالطريقة العادية عادة بتكون enzymatic
+
+304
+00:25:39,030 --> 00:25:43,310
+method تمام؟ ال kit تبعه لما نرجع الجامعة هنقرأ ال
+
+305
+00:25:43,310 --> 00:25:46,290
+kit ال pamphlet تبعته و نشوف قلية شغله
+
+306
+00:25:51,150 --> 00:25:54,670
+لـ precipitation methods حكينا in the plasma
+
+307
+00:25:54,670 --> 00:25:58,570
+كوليسترول is transported by three ليبوبروتين في
+
+308
+00:25:58,570 --> 00:26:03,890
+البلازمة الكوليسترول ينقل عن طريق تلت نواقل الـ
+
+309
+00:26:03,890 --> 00:26:07,270
+high-density ليبوبروتين الـ HDL والـ low-density
+
+310
+00:26:07,270 --> 00:26:10,510
+ليبوبروتين الـ LDL والـ very low-density
+
+311
+00:26:10,510 --> 00:26:14,860
+ليبوبروتينقلنا إن الـ VLDL هذا الـ Very low
+
+312
+00:26:14,860 --> 00:26:18,400
+density lipoprotein بنقل لـ Triglyceride بشكل
+
+313
+00:26:18,400 --> 00:26:24,880
+أساسي وأيضا ينقل لكلسترول ولكن بنسبة قليلةأما الـ
+
+314
+00:26:24,880 --> 00:26:32,160
+HDL و الـ LDL هدول نواقل خاصة بالكلسترول الـ HDL
+
+315
+00:26:32,160 --> 00:26:37,380
+-Lipoproteins are assayed كيف أنا ممكن يعني أقيس
+
+316
+00:26:37,380 --> 00:26:42,600
+الكلسترول اللي بيحمله الـ HDL هذا الناقل الـ High
+
+317
+00:26:42,600 --> 00:26:47,620
+Density Lipoprotein عن طريق أني أرسب النواقل
+
+318
+00:26:47,620 --> 00:26:53,260
+الأخرى أرسب الـ LDLوالـ VLDL في القاع ومين بيضل
+
+319
+00:26:53,260 --> 00:26:57,460
+الـ supernatant في الـ supernatant بيضل الـ HDL
+
+320
+00:26:58,780 --> 00:27:02,700
+الترسيب بيكون بواسطة مادة اسمها الـ Polyethylene
+
+321
+00:27:02,700 --> 00:27:07,380
+Glycol هذه مادة بتكون موجودة بالـ Reagent تبع الـ
+
+322
+00:27:07,380 --> 00:27:11,540
+kit تبع فحص الـ HDL لما بضيف الـ Reagent على
+
+323
+00:27:11,540 --> 00:27:14,840
+السيرم الـ Reagent فيه مادة الـ Polyethylene
+
+324
+00:27:14,840 --> 00:27:19,280
+Glycol اللي بترسب الـ LDL و الـ VLDL و
+
+325
+00:27:19,280 --> 00:27:23,610
+الكايلومايكرونفقط هيضلوا في الـ supernatant الـ
+
+326
+00:27:23,610 --> 00:27:29,650
+HDL بناخده و بنحسب تركيز الكوليسترول اللي بيكون
+
+327
+00:27:29,650 --> 00:27:34,910
+جوات الـ HDL HDL is left in the supernatant
+
+328
+00:27:34,910 --> 00:27:39,170
+solution for cholesterol quantitation عشان نقيس
+
+329
+00:27:39,170 --> 00:27:46,200
+تركيز الكوليسترول اللي جواته وهذا فحص الـ HDLCHDL
+
+330
+00:27:46,200 --> 00:27:51,640
+كوليسترول يعني حساب الكوليسترول اللي موجود ومحمول
+
+331
+00:27:51,640 --> 00:28:00,180
+على اللايبو بروتين HDL low density lipoprotein الـ
+
+332
+00:28:00,180 --> 00:28:07,280
+LDL الناقل الآخرهلجيت يا جماعة الـ LDL برضه إله
+
+333
+00:28:07,280 --> 00:28:12,600
+كيت خاص فيه عشان من خلال هذا الـ kit انقيس تركيز
+
+334
+00:28:12,600 --> 00:28:17,180
+الكوليسترول اللي موجود في هذا الناقل في الـ LDL
+
+335
+00:28:17,180 --> 00:28:23,130
+لكن جاله فيه طريقة سهلةممكن من خلال معادلة اسمها
+
+336
+00:28:23,130 --> 00:28:28,230
+Fredwald equation أطبقها وبالتالي من خلالها بقدر
+
+337
+00:28:28,230 --> 00:28:32,570
+أعرف تركيز الكوليسترول اللي موجود و اللي محمول
+
+338
+00:28:32,570 --> 00:28:38,710
+داخل الـ LDL الـ LDL كوليسترول، تركيز الكوليسترول
+
+339
+00:28:38,710 --> 00:28:45,310
+اللي محمول بواسطة الـ LDL إيش بدو يساوي؟بدو يساوي
+
+340
+00:28:45,310 --> 00:28:51,050
+الـ Total Cholesterol أي تركيز الكوليسترول الكامل
+
+341
+00:28:51,050 --> 00:28:56,850
+اللي حسبناه في البلازمة ناقص الـ HDL-cholesterol
+
+342
+00:28:56,850 --> 00:29:03,610
+يعني ناقص الكوليسترول اللي موجود ومحمول داخل الـ
+
+343
+00:29:03,610 --> 00:29:08,370
+HDL ما هذا برضه احنا جبناه وحسبناه بطريقة الـ kit
+
+344
+00:29:08,370 --> 00:29:13,910
+و Total Cholesterol حسبناهحكيته لكم الطريقة الـ
+
+345
+00:29:13,910 --> 00:29:19,430
+procedure تبعته ناقص لـ triglyceride تركيز لـ
+
+346
+00:29:19,430 --> 00:29:24,850
+triglyceride على 2.2 بتجسمي نتيجة لـ triglyceride
+
+347
+00:29:24,850 --> 00:29:33,020
+على 2.2والنتيجة اللى تطلع هو تركيز الكوليسترول
+
+348
+00:29:33,020 --> 00:29:40,480
+اللى موجود داخل الـ LDL و الوحدة بتكون بالملي مول
+
+349
+00:29:40,480 --> 00:29:47,670
+per لترلكن يا جماعة لو جسمت لـ Triglyceride على
+
+350
+00:29:47,670 --> 00:29:54,390
+الرقم 5 تمام؟ النتيجة هتطلع بالـ milligram per
+
+351
+00:29:54,390 --> 00:30:01,820
+deciliter وبيحكيلنا كمان شغلةللـ Triglyceride،
+
+352
+00:30:01,820 --> 00:30:08,000
+تركيز الدهون التلاتية، لو جسمتها على خمسة، هيعطيني
+
+353
+00:30:08,000 --> 00:30:13,520
+الـ VLDL كوليسترول، كمية الكوليسترول اللى موجودة
+
+354
+00:30:13,520 --> 00:30:17,940
+داخل الـ VLDL اللى حاملها الـ Very Low Density
+
+355
+00:30:17,940 --> 00:30:22,120
+Libo Protein إذا ماعليش، حلينا نعيد الـ slide كمان
+
+356
+00:30:22,120 --> 00:30:27,530
+مرةلو بدى احسب الكوليسترول تركيزه اللى موجود على
+
+357
+00:30:27,530 --> 00:30:32,470
+ناقل الـ LDL داخل الـ LDL هيساوي الـ Total
+
+358
+00:30:32,470 --> 00:30:36,550
+Cholesterol اللى حسبناه بالـ Slides الأولى فحص
+
+359
+00:30:36,550 --> 00:30:40,070
+الكوليسترول تفحص الكوليسترول في السيرم أو البلازمة
+
+360
+00:30:40,070 --> 00:30:46,040
+ككلبتسجل نتيجته ناقص HDL كوليسترول تركيز
+
+361
+00:30:46,040 --> 00:30:50,460
+الكوليسترول اللى جوهة الـ HDL هذا حسبناه بطريقة
+
+362
+00:30:50,460 --> 00:30:54,120
+الـ precipitation وقولنا ان ال procedure بتاعة ال
+
+363
+00:30:54,120 --> 00:31:00,380
+method لما نرجع الجامعة هنتعلمهاناقص لـ
+
+364
+00:31:00,380 --> 00:31:05,960
+Triglyceride حسبنا تركيزه على 2.2 فهتطلع النتيجة
+
+365
+00:31:05,960 --> 00:31:10,680
+بالـ millimole per liter لكن لو بد النتيجة
+
+366
+00:31:10,680 --> 00:31:15,060
+بالmilligram per deciliter وهي الوحدة الأكثر شيوعا
+
+367
+00:31:15,060 --> 00:31:20,540
+بجسم ل Triglyceride بدل ما هي على 2.2 بجسمها على 5
+
+368
+00:31:21,360 --> 00:31:25,940
+وقلنا هذه معادلة لو جبت تركيز لـ Triglyceride
+
+369
+00:31:25,940 --> 00:31:32,080
+وجسمته على خمسة هيطلع لتركيز الكوليسترول اللي
+
+370
+00:31:32,080 --> 00:31:38,940
+محمول جوات الـ VLDL تمام؟ إذنWhere all
+
+371
+00:31:38,940 --> 00:31:42,180
+concentrations are given in millimoles per liter
+
+372
+00:31:42,180 --> 00:31:47,420
+المعادلة الزرجة لو كل الوحدات كانت يعني لما أجسمها
+
+373
+00:31:47,420 --> 00:31:51,840
+2.2 لـ triglyceride الوحدة بتطلع بالmillimoles per
+
+374
+00:31:51,840 --> 00:31:58,250
+literإذا كتبت تركيز الكوليسترول بالملي جرام بار دي
+
+375
+00:31:58,250 --> 00:32:02,230
+سيلتر لو أنا بدي المعادلة بالملي جرام بار دي سيلتر
+
+376
+00:32:02,230 --> 00:32:05,890
+و النتيجة تركيز الكوليسترول بالملي جرام بار دي
+
+377
+00:32:05,890 --> 00:32:11,130
+سيلتر بديك تجسم لـ Triglyceride على خمسة بدل من 2
+
+378
+00:32:11,130 --> 00:32:17,390
+.2 The Quotient Triglyceride على خمسة لو جسمت لـ
+
+379
+00:32:17,390 --> 00:32:22,890
+Triglyceride على خمسةis used and estimate هيك أنا
+
+380
+00:32:22,890 --> 00:32:29,750
+بقدر اعرف تركيز الكلسترول اللي محمول بالـ VLDL
+
+381
+00:32:31,340 --> 00:32:35,880
+بحكيلي آخر جملة The virtually all of the plasma
+
+382
+00:32:35,880 --> 00:32:41,980
+triglyceride is carried on VLDL كل triglyceride
+
+383
+00:32:41,980 --> 00:32:46,080
+اللي موجودة في البلازمة واللي مصدرها من الكبد
+
+384
+00:32:46,080 --> 00:32:52,350
+تصنعت في الكبد تحمل عن طريق ال VLDLand second that
+
+385
+00:32:52,350 --> 00:32:56,670
+the triglyceride cholesterol ratio of VLDL is
+
+386
+00:32:56,670 --> 00:33:03,010
+constant at about 5.1 بيحكيلي يعني ال VLDL بينقل
+
+387
+00:33:03,010 --> 00:33:07,890
+Triglyceride و Cholesterolولكن بينقل الـ
+
+388
+00:33:07,890 --> 00:33:12,770
+Triglyceride بكميات أكبر من الكوليسترول يعني حوالي
+
+389
+00:33:12,770 --> 00:33:17,410
+بينقل خمسة إلى واحد خمسة part من الـ Triglyceride
+
+390
+00:33:17,410 --> 00:33:23,940
+مع واحد part من الكوليسترول تمام؟طبعا يا جماعة إذا
+
+391
+00:33:23,940 --> 00:33:27,680
+ما بدنا نطبق المعادلة عشان نحسب الكوليسترول اللي
+
+392
+00:33:27,680 --> 00:33:33,040
+موجود في الـ LDL فيه هناك kit خاص و procedure خاصة
+
+393
+00:33:33,040 --> 00:33:37,300
+هنشتغلها عملي كيف نحسب الكوليسترول اللي موجود في
+
+394
+00:33:37,300 --> 00:33:44,150
+الـ LDL وشغل عملي مش بس بتطبيق معادلةالمعادلة هذه
+
+395
+00:33:44,150 --> 00:33:49,230
+اسمها Fredwald equation للأسف مش في كل الحالات
+
+396
+00:33:49,230 --> 00:33:54,810
+بنفع أطبق هذه المعادلة وأحسب الكوليسترول تركيزه
+
+397
+00:33:54,810 --> 00:34:00,210
+اللي موجود في الـ LDL فيه limitations في محددات
+
+398
+00:34:00,210 --> 00:34:05,770
+لاستخدام هذه المعادلة في حالات هذه الحالات لو
+
+399
+00:34:05,770 --> 00:34:13,880
+انواجهت حالة واحدة منهايمنع استخدام وتطبيق معادلة
+
+400
+00:34:13,880 --> 00:34:18,920
+الـ Fredwald equation لحساب الكوليسترول من الـ LDL
+
+401
+00:34:18,920 --> 00:34:22,920
+وفي هذه الحالة لازم ألجأ للـ kit و أشتغل الفحث
+
+402
+00:34:22,920 --> 00:34:27,080
+عملي عشان أحسب تركيز الكوليسترول اللي موجود في الـ
+
+403
+00:34:27,080 --> 00:34:32,160
+LDL بقول لي when Kilomicron are present in plasma
+
+404
+00:34:32,160 --> 00:34:37,750
+لو كان المريض عنده Kilomicron في البلازمةالـ
+
+405
+00:34:37,750 --> 00:34:42,490
+Kylomicron نوع من أنواع نواقل الدهون يا جماعة ومش
+
+406
+00:34:42,490 --> 00:34:47,730
+دايما تظهر في البلازمة تظهر في البلازمة في حالة
+
+407
+00:34:47,730 --> 00:34:51,710
+الـ non fasting في حالة عدب الصيام يعني أنت بتاكل
+
+408
+00:34:51,710 --> 00:34:55,990
+فانت بتاكل أكل مثلا فيه دهون تلاتية هذه الدهون
+
+409
+00:34:55,990 --> 00:34:59,330
+التلاتية مصدرها من الأكل اللي بتيجي على الدم مين
+
+410
+00:34:59,330 --> 00:35:04,280
+بده يحملها حكيمة بيحملها الـ Kylomicron فتتصنعلكن
+
+411
+00:35:04,280 --> 00:35:09,180
+في حال انت fast انت صايم معناه مافيش أكل مافيش
+
+412
+00:35:09,180 --> 00:35:13,060
+دهون تلاتية مصدرها خارجي وبالتالي ال kylo micron
+
+413
+00:35:13,060 --> 00:35:17,620
+مش هتتصنع ليش تتصنع ال kylo micron؟ إيش بدها تحمل؟
+
+414
+00:35:17,620 --> 00:35:21,960
+مش هتحمل حاجة إذا في حالة ال fasting ما بشوف ال
+
+415
+00:35:21,960 --> 00:35:25,640
+kylo micron في بلازمة الإنسان في حالة ال non
+
+416
+00:35:25,640 --> 00:35:30,260
+fasting يعني الأكل بشوف ال kylo micron في بلازمة
+
+417
+00:35:30,260 --> 00:35:38,070
+الإنسان يعني لمايعني في حالة انت مش صايم وعندك
+
+418
+00:35:38,070 --> 00:35:43,050
+كايلو مايكرونز في البلازمة ممنوع تطبق هذه المعادلة
+
+419
+00:35:43,050 --> 00:35:47,290
+عشان تحسب تركيز الكوليسترول اللي موجود في الـ LDL
+
+420
+00:35:48,220 --> 00:35:52,300
+حالة أخرى لو فحصت عندك الدهون التلاتية ولاجتها
+
+421
+00:35:52,300 --> 00:35:58,040
+أعلى من 400 milligram per deciliter ممنوع أستخدم
+
+422
+00:35:58,040 --> 00:36:03,260
+هذه المعادلة عشان أحسب تركيز الكوليسترول في الـ
+
+423
+00:36:03,260 --> 00:36:08,540
+LDL ممنوع لازم أستخدم الـ kit و أستخدم الـ reagent
+
+424
+00:36:08,540 --> 00:36:11,760
+و الطريقة العملية عشان أحسب تركيز الكوليسترول اللي
+
+425
+00:36:11,760 --> 00:36:15,640
+موجود في الـ LDL أيضا في ال patients في المرضى
+
+426
+00:36:15,640 --> 00:36:20,260
+اللي عندهم حالةمرضية اسمها الـ Dis-Beta
+
+427
+00:36:20,260 --> 00:36:25,640
+-Libobrotonemia لما أحكيلكم Alpha يعني أقصد الـ
+
+428
+00:36:25,640 --> 00:36:32,260
+HDL لما أحكيلكم Beta معناها الـ LDL لما أحكيلكم
+
+429
+00:36:32,260 --> 00:36:38,980
+Pre-Beta معناها الـ VLDL فDis-Beta يعني مشكلة في
+
+430
+00:36:38,980 --> 00:36:44,690
+الـ LDLLiboprotonemia يعني عندنا الـ Type 3 Hyper
+
+431
+00:36:44,690 --> 00:36:49,450
+-Liboprotonemia يعني المريض عنده Hyper ارتفاع في
+
+432
+00:36:49,450 --> 00:36:53,790
+الـ Beta يعني في الـ LDL من نوع الـ Type 3 هتاخدوه
+
+433
+00:36:53,790 --> 00:36:59,510
+مع الدكتور مثلا سواء هذه الحالة اللي تحت أو الحالة
+
+434
+00:36:59,510 --> 00:37:03,970
+التانية أو الحالة الأولى لو ان وجدت واحدة منهم
+
+435
+00:37:04,850 --> 00:37:09,070
+ساعتها ممنوع تستخدم الـ Fredwald equation ممنوع
+
+436
+00:37:09,070 --> 00:37:15,130
+ممنوع أستخدم المعادلة فلازم أحسب تركيز الكوليسترول
+
+437
+00:37:15,130 --> 00:37:20,270
+اللي موجود في الـ LDL بطريقة الـ KET مش بالمعادلة
+
+438
+00:37:20,270 --> 00:37:24,810
+سريعا، تمام؟ يا جماعة لما كنت أحكيلكم Normal Range
+
+439
+00:37:24,810 --> 00:37:29,990
+للـ HDL لازم يكون أعلى من 60 ملي جرام per
+
+440
+00:37:29,990 --> 00:37:37,410
+deciliterتركيز الـ Cholesterol الموجود أو المحمول
+
+441
+00:37:37,410 --> 00:37:44,270
+في الـ HDLولمّا أحكي لكم إن تركيز الـ LDL أقل من
+
+442
+00:37:44,270 --> 00:37:49,410
+100 ميلي جرام per deciliter يعني تركيز الكوليسترول
+
+443
+00:37:49,410 --> 00:37:54,970
+اللي محمول جوات الـ LDL لازم يكون أقل من 100 ميلي
+
+444
+00:37:54,970 --> 00:38:00,130
+جرام per deciliter بس حبيت أنبه لهذه الشغلة إن أنا
+
+445
+00:38:00,130 --> 00:38:05,550
+بقيس تركيز الكوليسترول اللي موجودة في النواقل
+
+446
+00:38:05,550 --> 00:38:07,570
+تمام؟ يعطيكم العافية
+
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/SjaAdCYcBak_raw.json b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/SjaAdCYcBak_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..e45d9475b604c5ee6feed2c98711a2f13af6dc22
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/SjaAdCYcBak_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2185, "start": 0.59, "end": 21.85, "text": "مبدأ شغل الـ KET بكل بساطة Endymetic Method بتروح تجيبي عينة المريض Serum أو البلازمة بيكون فيها الدهون التلاتية إذاً الـ Triglycerides بيكون موجود في الـ Serum أو البلازمة تبع المريض وبتروح تجيبي الـ Reagent اللي موجود في KET", "tokens": [2304, 44510, 10721, 13412, 17082, 1211, 2423, 39184, 591, 4850, 4724, 28820, 4724, 3794, 41193, 3660, 6967, 4199, 3532, 25285, 39894, 32887, 5016, 6055, 7435, 1829, 21292, 6225, 9957, 3660, 9673, 16572, 11242, 4210, 449, 34051, 29739, 1211, 31377, 46007, 4724, 1829, 30544, 8978, 11296, 32748, 3224, 11536, 16712, 1211, 9307, 10632, 11933, 15730, 14111, 2423, 39184, 1765, 328, 356, 1776, 1875, 4724, 1829, 30544, 3714, 29245, 23328, 8978, 2423, 39184, 4210, 449, 34051, 29739, 1211, 31377, 46007, 6055, 3555, 3615, 9673, 16572, 11242, 46599, 2655, 32887, 5016, 6055, 7435, 1829, 21292, 2423, 39184, 1300, 559, 317, 13672, 1829, 3714, 29245, 23328, 8978, 591, 4850], "avg_logprob": 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{"start": 258.57, "end": 259.31, "word": " temperature", "probability": 0.96044921875}, {"start": 259.31, "end": 260.29, "word": " أو", "probability": 0.7333984375}, {"start": 260.29, "end": 261.01, "word": " ممكن", "probability": 0.99072265625}, {"start": 261.01, "end": 261.63, "word": " تاخد", "probability": 0.9635416666666666}, {"start": 261.63, "end": 262.31, "word": " الأنابيب", "probability": 0.8946533203125}, {"start": 262.31, "end": 262.53, "word": " و", "probability": 0.78759765625}, {"start": 262.53, "end": 263.05, "word": " تحطيها", "probability": 0.9953125}, {"start": 263.05, "end": 263.21, "word": " في", "probability": 0.9765625}, {"start": 263.21, "end": 263.33, "word": " ال", "probability": 0.978515625}, {"start": 263.33, "end": 263.67, "word": " water", "probability": 0.89892578125}, {"start": 263.67, "end": 264.19, "word": " bath", "probability": 0.93994140625}, {"start": 264.19, "end": 264.85, "word": " لمدة", "probability": 0.959228515625}, {"start": 264.85, "end": 265.39, "word": " 5", "probability": 0.87158203125}, {"start": 265.39, "end": 266.43, "word": " دقائق", "probability": 0.9871826171875}], "temperature": 1.0}, {"id": 11, "seek": 28773, "start": 267.11, "end": 287.73, "text": "بعدين بتقرأي هال جيت بتجيب ال blank و بتسفر ال spectrophotometer على ال blank بعدين بتحطي انبوبة ال standard بتحطيها ب QVIT السائل اللي جوا انبوبة ال standard بتحطيها في ال QVIT و بتقرايها إذا إحنا أخدنا ال absorbance لل standard", "tokens": [3555, 22488, 9957, 39894, 4587, 2288, 10721, 1829, 8032, 6027, 10874, 36081, 39894, 7435, 1829, 3555, 2423, 8247, 4032, 39894, 3794, 5172, 2288, 2423, 6177, 11741, 310, 13606, 15844, 2423, 8247, 39182, 9957, 39894, 5016, 9566, 1829, 16472, 3555, 37746, 3660, 2423, 3832, 39894, 5016, 9566, 1829, 11296, 4724, 1249, 53, 3927, 21136, 16373, 1211, 13672, 1829, 10874, 14407, 16472, 3555, 37746, 3660, 2423, 3832, 39894, 5016, 9566, 1829, 11296, 8978, 2423, 1249, 53, 3927, 4032, 39894, 4587, 23557, 1829, 11296, 11933, 15730, 11933, 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0.9033203125}, {"start": 271.17, "end": 272.19, "word": " spectrophotometer", "probability": 0.8145751953125}, {"start": 272.19, "end": 272.43, "word": " على", "probability": 0.65087890625}, {"start": 272.43, "end": 272.57, "word": " ال", "probability": 0.916015625}, {"start": 272.57, "end": 272.97, "word": " blank", "probability": 0.7939453125}, {"start": 272.97, "end": 273.81, "word": " بعدين", "probability": 0.84912109375}, {"start": 273.81, "end": 275.09, "word": " بتحطي", "probability": 0.966064453125}, {"start": 275.09, "end": 276.05, "word": " انبوبة", "probability": 0.8238525390625}, {"start": 276.05, "end": 276.19, "word": " ال", "probability": 0.85009765625}, {"start": 276.19, "end": 276.67, "word": " standard", "probability": 0.91552734375}, {"start": 276.67, "end": 277.43, "word": " بتحطيها", "probability": 0.9435546875}, {"start": 277.43, "end": 277.57, "word": " ب", "probability": 0.5986328125}, {"start": 277.57, "end": 278.19, "word": " QVIT", "probability": 0.22705078125}, {"start": 278.19, "end": 279.87, "word": " السائل", "probability": 0.931640625}, {"start": 279.87, "end": 280.03, "word": " اللي", "probability": 0.8955078125}, {"start": 280.03, "end": 280.31, "word": " جوا", "probability": 0.8642578125}, {"start": 280.31, "end": 280.89, "word": " انبوبة", "probability": 0.870849609375}, {"start": 280.89, "end": 281.01, "word": " ال", "probability": 0.84521484375}, {"start": 281.01, "end": 281.37, "word": " standard", "probability": 0.96728515625}, {"start": 281.37, "end": 282.13, "word": " بتحطيها", "probability": 0.974609375}, {"start": 282.13, "end": 282.27, "word": " في", "probability": 0.84619140625}, {"start": 282.27, "end": 282.39, "word": " ال", "probability": 0.95654296875}, {"start": 282.39, "end": 282.85, "word": " QVIT", "probability": 0.9425455729166666}, {"start": 282.85, "end": 283.63, "word": " و", "probability": 0.556640625}, {"start": 283.63, "end": 284.55, "word": " بتقرايها", "probability": 0.87216796875}, {"start": 284.55, "end": 284.87, "word": " إذا", "probability": 0.6231689453125}, {"start": 284.87, "end": 285.39, "word": " إحنا", "probability": 0.7143961588541666}, {"start": 285.39, "end": 285.79, "word": " أخدنا", "probability": 0.9420166015625}, {"start": 285.79, "end": 285.93, "word": " ال", "probability": 0.83984375}, {"start": 285.93, "end": 286.87, "word": " absorbance", "probability": 0.91162109375}, {"start": 286.87, "end": 287.21, "word": " لل", "probability": 0.548828125}, {"start": 287.21, "end": 287.73, "word": " standard", "probability": 0.88525390625}], "temperature": 1.0}, {"id": 12, "seek": 31517, "start": 288.81, "end": 315.17, "text": "بعدين بتجيبى cuvette أخرى بتحط فيها مكونات ال sample و بتقرأى انبوبة ال sample و بتاخدى absorbance لل sample و التفاعل بيضلوا stable لمدة ساعة إذا أنا حصلت على ال absorbance لل standard و absorbance لل sample كيف بدي أطلّر تركيز الدهون التلاتية بطبق برزلو", "tokens": [3555, 22488, 9957, 39894, 7435, 1829, 3555, 7578, 2702, 41440, 5551, 34740, 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{"start": 290.51, "end": 291.15, "word": " أخرى", "probability": 0.9168294270833334}, {"start": 291.15, "end": 291.77, "word": " بتحط", "probability": 0.9275716145833334}, {"start": 291.77, "end": 292.19, "word": " فيها", "probability": 0.9697265625}, {"start": 292.19, "end": 293.25, "word": " مكونات", "probability": 0.9126953125}, {"start": 293.25, "end": 293.65, "word": " ال", "probability": 0.96337890625}, {"start": 293.65, "end": 294.07, "word": " sample", "probability": 0.53759765625}, {"start": 294.07, "end": 294.97, "word": " و", "probability": 0.60693359375}, {"start": 294.97, "end": 296.11, "word": " بتقرأى", "probability": 0.7833984375}, {"start": 296.11, "end": 296.81, "word": " انبوبة", "probability": 0.8612060546875}, {"start": 296.81, "end": 296.99, "word": " ال", "probability": 0.98828125}, {"start": 296.99, "end": 297.31, "word": " sample", "probability": 0.95947265625}, {"start": 297.31, "end": 297.53, "word": " و", "probability": 0.67822265625}, {"start": 297.53, "end": 298.01, "word": " بتاخدى", "probability": 0.853759765625}, {"start": 298.01, "end": 298.77, "word": " absorbance", "probability": 0.903564453125}, {"start": 298.77, "end": 298.97, "word": " لل", "probability": 0.6025390625}, {"start": 298.97, "end": 299.47, "word": " sample", "probability": 0.93505859375}, {"start": 299.47, "end": 300.25, "word": " و", "probability": 0.55712890625}, {"start": 300.25, "end": 301.59, "word": " التفاعل", "probability": 0.9168701171875}, {"start": 301.59, "end": 302.27, "word": " بيضلوا", "probability": 0.76865234375}, {"start": 302.27, "end": 303.09, "word": " stable", "probability": 0.88134765625}, {"start": 303.09, "end": 303.85, "word": " لمدة", "probability": 0.95263671875}, {"start": 303.85, "end": 304.37, "word": " ساعة", "probability": 0.9856770833333334}, {"start": 304.37, "end": 305.25, "word": " إذا", "probability": 0.6685791015625}, {"start": 305.25, "end": 305.55, "word": " أنا", "probability": 0.499267578125}, {"start": 305.55, "end": 306.09, "word": " حصلت", "probability": 0.9866536458333334}, {"start": 306.09, "end": 306.33, "word": " على", "probability": 0.90234375}, {"start": 306.33, "end": 306.63, "word": " ال", "probability": 0.81982421875}, {"start": 306.63, "end": 307.55, "word": " absorbance", "probability": 0.962890625}, {"start": 307.55, "end": 307.89, "word": " لل", "probability": 0.78857421875}, {"start": 307.89, "end": 308.53, "word": " standard", "probability": 0.8623046875}, {"start": 308.53, "end": 308.83, "word": " و", "probability": 0.8408203125}, {"start": 308.83, "end": 309.67, "word": " absorbance", "probability": 0.812744140625}, {"start": 309.67, "end": 309.97, "word": " لل", "probability": 0.94189453125}, {"start": 309.97, "end": 310.41, "word": " sample", "probability": 0.95166015625}, {"start": 310.41, "end": 310.89, "word": " كيف", "probability": 0.95703125}, {"start": 310.89, "end": 311.15, "word": " بدي", "probability": 0.870849609375}, {"start": 311.15, "end": 311.59, "word": " أطلّر", "probability": 0.834033203125}, {"start": 311.59, "end": 312.13, "word": " تركيز", "probability": 0.99072265625}, {"start": 312.13, "end": 312.57, "word": " الدهون", "probability": 0.9563802083333334}, {"start": 312.57, "end": 313.29, "word": " التلاتية", "probability": 0.87158203125}, {"start": 313.29, "end": 314.27, "word": " بطبق", "probability": 0.8310546875}, {"start": 314.27, "end": 315.17, "word": " برزلو", "probability": 0.6513671875}], "temperature": 1.0}, {"id": 13, "seek": 32401, "start": 316.23, "end": 324.01, "text": "الـ Concentration للـ Triglyceride في عينة المريض يساوي الـ Absorbance", "tokens": [6027, 39184, 2656, 2207, 2405, 24976, 39184, 1765, 328, 356, 1776, 482, 8978, 6225, 9957, 3660, 9673, 16572, 11242, 7251, 3794, 995, 45865, 2423, 39184, 5813, 30907, 719], "avg_logprob": -0.14507004721411343, "compression_ratio": 1.0434782608695652, "no_speech_prob": 0.0, "words": [{"start": 316.23, "end": 316.65, "word": "الـ", "probability": 0.947265625}, {"start": 316.65, "end": 317.75, "word": " Concentration", "probability": 0.8129069010416666}, {"start": 317.75, "end": 318.37, "word": " للـ", "probability": 0.78369140625}, {"start": 318.37, "end": 319.57, "word": " Triglyceride", "probability": 0.86640625}, {"start": 319.57, "end": 319.97, "word": " في", "probability": 0.880859375}, {"start": 319.97, "end": 320.61, "word": " عينة", "probability": 0.900390625}, {"start": 320.61, "end": 321.23, "word": " المريض", "probability": 0.92333984375}, {"start": 321.23, "end": 322.05, "word": " يساوي", "probability": 0.9613037109375}, {"start": 322.05, "end": 323.03, "word": " الـ", "probability": 0.77197265625}, {"start": 323.03, "end": 324.01, "word": " Absorbance", "probability": 0.8544921875}], "temperature": 1.0}, {"id": 14, "seek": 34614, "start": 325.64, "end": 346.14, "text": "تبع الـ Patient Sample على الـ Absorbance للـ Standard درب الـ Concentration للـ Standard الـ Absorbance للـ Patient Sample معروف والـ Absorbance للـ Standard معروف والـ Concentration للـ Standard معروف إذا بقدر أعرف الـ Concentration", "tokens": [2655, 3555, 3615, 2423, 39184, 25173, 4832, 781, 15844, 2423, 39184, 5813, 30907, 719, 24976, 39184, 21298, 11778, 25513, 2423, 39184, 2656, 2207, 2405, 24976, 39184, 21298, 2423, 39184, 5813, 30907, 719, 24976, 39184, 25173, 4832, 781, 20449, 32887, 5172, 16070, 39184, 5813, 30907, 719, 24976, 39184, 21298, 20449, 32887, 5172, 16070, 39184, 2656, 2207, 2405, 24976, 39184, 21298, 20449, 32887, 5172, 11933, 15730, 4724, 28543, 2288, 5551, 3615, 28480, 2423, 39184, 2656, 2207, 2405], "avg_logprob": -0.15851150904046862, "compression_ratio": 2.1619718309859155, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 325.64, "end": 326.12, "word": "تبع", "probability": 0.770263671875}, {"start": 326.12, "end": 326.8, "word": " الـ", "probability": 0.87841796875}, {"start": 326.8, "end": 327.1, "word": " Patient", "probability": 0.385986328125}, {"start": 327.1, "end": 327.74, "word": " Sample", "probability": 0.7548828125}, {"start": 327.74, "end": 328.32, "word": " على", "probability": 0.7216796875}, {"start": 328.32, "end": 329.04, "word": " الـ", "probability": 0.936767578125}, {"start": 329.04, "end": 330.1, "word": " Absorbance", "probability": 0.80322265625}, {"start": 330.1, "end": 330.98, "word": " للـ", "probability": 0.5618896484375}, {"start": 330.98, "end": 331.94, "word": " Standard", "probability": 0.83935546875}, {"start": 331.94, "end": 332.62, "word": " درب", "probability": 0.623046875}, {"start": 332.62, "end": 333.12, "word": " الـ", "probability": 0.9345703125}, {"start": 333.12, "end": 334.02, "word": " Concentration", "probability": 0.9710286458333334}, {"start": 334.02, "end": 334.38, "word": " للـ", "probability": 0.84423828125}, {"start": 334.38, "end": 334.76, "word": " Standard", "probability": 0.9541015625}, {"start": 334.76, "end": 335.56, "word": " الـ", "probability": 0.80859375}, {"start": 335.56, "end": 336.18, "word": " Absorbance", 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{"start": 717.06, "end": 717.54, "word": " Reagent", "probability": 0.9033203125}, {"start": 717.54, "end": 718.68, "word": " وشدت", "probability": 0.852783203125}, {"start": 718.68, "end": 718.96, "word": " اللون", "probability": 0.82373046875}, {"start": 718.96, "end": 719.52, "word": " تتناسب", "probability": 0.912353515625}, {"start": 719.52, "end": 720.02, "word": " تناسب", "probability": 0.92041015625}, {"start": 720.02, "end": 720.44, "word": " تردي", "probability": 0.7325846354166666}, {"start": 720.44, "end": 720.62, "word": " مع", "probability": 0.986328125}, {"start": 720.62, "end": 721.12, "word": " تركيز", "probability": 0.9940185546875}, {"start": 721.12, "end": 721.88, "word": " الكوليسترول", "probability": 0.9734700520833334}, {"start": 721.88, "end": 722.24, "word": " اللي", "probability": 0.9560546875}, {"start": 722.24, "end": 722.68, "word": " موجود", "probability": 0.9873046875}, {"start": 722.68, "end": 722.98, "word": " في", "probability": 0.98876953125}, {"start": 722.98, "end": 724.2, "word": " العينة", "probability": 0.9285481770833334}, {"start": 724.2, "end": 724.92, "word": " تمام؟", "probability": 0.7998046875}], "temperature": 1.0}, {"id": 32, "seek": 73215, "start": 725.67, "end": 732.15, "text": "نفس مبدأ شغل كتات لـ Triglyceride والسكر والـ Total Protein والألبما", "tokens": [1863, 36178, 3714, 44510, 10721, 13412, 17082, 1211, 9122, 2655, 9307, 5296, 39184, 1765, 328, 356, 1776, 482, 16070, 3794, 37983, 16070, 39184, 23170, 43371, 259, 16070, 10721, 46152, 15042], "avg_logprob": -0.2183719748450864, "compression_ratio": 1.0515463917525774, "no_speech_prob": 0.0, "words": [{"start": 725.67, "end": 726.21, "word": "نفس", "probability": 0.908203125}, {"start": 726.21, "end": 726.91, "word": " مبدأ", "probability": 0.8819986979166666}, {"start": 726.91, "end": 727.81, "word": " شغل", "probability": 0.9542643229166666}, {"start": 727.81, "end": 728.45, "word": " كتات", "probability": 0.935546875}, {"start": 728.45, "end": 728.67, "word": " لـ", "probability": 0.703125}, {"start": 728.67, "end": 729.69, "word": " Triglyceride", "probability": 0.776806640625}, {"start": 729.69, "end": 730.31, "word": " والسكر", "probability": 0.8701171875}, {"start": 730.31, "end": 730.59, "word": " والـ", "probability": 0.871826171875}, {"start": 730.59, "end": 730.77, "word": " Total", "probability": 0.5859375}, {"start": 730.77, "end": 731.45, "word": " Protein", "probability": 0.824951171875}, {"start": 731.45, "end": 732.15, "word": " والألبما", "probability": 0.714111328125}], "temperature": 1.0}, {"id": 33, "seek": 76350, "start": 733.74, "end": 763.5, "text": "الـ procedure نفس شغل لـ Triglyceride بتجيبي تلتة أنبيب بتعملي blank بتعملي label تكتبي على الأنبوبة الأولى blank تانية standard تالتة sample بتجيبي الـ reagent الخاص بالكوليسترول بتحطي على كل tube واحد أمقل بتجيبي ال standard اللي جواته كوليسترول واللي تركيزه معلوم تاخد منه عشرة micron بيكون في ال kit تبع الكوليسترول وبتحطيه في أنبوبة ال standard وبتعملي mix", 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" mix", "probability": 0.9736328125}], "temperature": 1.0}, {"id": 34, "seek": 77523, "start": 763.83, "end": 775.23, "text": "و بتجيب ال patient sample serum أو البلازمة بتاخد منها 10 مايكرون و بتحطيها في انبوبة ال sample و بتجيب 10 مايكرون من ال distilled water و بتحطيها على ال blank", "tokens": [2407, 39894, 7435, 1829, 3555, 2423, 4537, 6889, 32755, 34051, 29739, 1211, 31377, 46007, 39894, 47283, 3215, 9154, 11296, 1266, 19446, 1829, 37983, 11536, 4032, 39894, 5016, 9566, 1829, 11296, 8978, 16472, 3555, 37746, 3660, 2423, 6889, 4032, 39894, 7435, 1829, 3555, 1266, 19446, 1829, 37983, 11536, 9154, 2423, 1483, 6261, 1281, 4032, 39894, 5016, 9566, 1829, 11296, 15844, 2423, 8247], "avg_logprob": -0.20438508256789176, "compression_ratio": 1.535031847133758, "no_speech_prob": 1.0728836059570312e-06, "words": [{"start": 763.83, "end": 764.11, "word": "و", "probability": 0.35986328125}, {"start": 764.11, "end": 764.57, "word": " بتجيب", "probability": 0.93603515625}, {"start": 764.57, 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في", "probability": 0.91064453125}, {"start": 769.39, "end": 769.91, "word": " انبوبة", "probability": 0.913330078125}, {"start": 769.91, "end": 770.07, "word": " ال", "probability": 0.9716796875}, {"start": 770.07, "end": 770.43, "word": " sample", "probability": 0.8916015625}, {"start": 770.43, "end": 771.31, "word": " و", "probability": 0.6474609375}, {"start": 771.31, "end": 771.71, "word": " بتجيب", "probability": 0.9569091796875}, {"start": 771.71, "end": 772.01, "word": " 10", "probability": 0.390380859375}, {"start": 772.01, "end": 772.63, "word": " مايكرون", "probability": 0.970947265625}, {"start": 772.63, "end": 772.81, "word": " من", "probability": 0.9921875}, {"start": 772.81, "end": 772.95, "word": " ال", "probability": 0.9609375}, {"start": 772.95, "end": 773.37, "word": " distilled", "probability": 0.864013671875}, {"start": 773.37, "end": 773.69, "word": " water", "probability": 0.9521484375}, {"start": 773.69, "end": 773.79, "word": " و", "probability": 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الوحدة هتطلع بال milligram per deciliter أيضا ال normal range للكوليسترول في الجسم لازم يكون أقل من 200 milligram per deciliter و بدناش ننسى", "tokens": [2655, 47283, 3215, 2423, 39184, 5813, 30907, 719, 24976, 39184, 21298, 4032, 39182, 9957, 2423, 39184, 5813, 30907, 719, 24976, 39184, 4832, 781, 4032, 39182, 9957, 39894, 9566, 3555, 4587, 4724, 13546, 1829, 11622, 20193, 6225, 8592, 7649, 6055, 5016, 3794, 4724, 2655, 31747, 1829, 11622, 33251, 12610, 1829, 14851, 2288, 12610, 8978, 6225, 9957, 3660, 2423, 4537, 4032, 2423, 2407, 24401, 3660, 8032, 2655, 9566, 1211, 3615, 20666, 38298, 680, 979, 388, 1681, 36632, 11242, 995, 2423, 2710, 3613, 5296, 23275, 12610, 1829, 14851, 2288, 12610, 8978, 25724, 38251, 5296, 31377, 2304, 7251, 30544, 5551, 4587, 1211, 9154, 2331, 38298, 680, 979, 388, 1681, 4032, 47525, 8315, 8592, 8717, 1863, 3794, 7578], "avg_logprob": -0.2023026310560996, "compression_ratio": 1.7208333333333334, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 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"word": " و", "probability": 0.62548828125}, {"start": 815.29, "end": 815.91, "word": " الوحدة", "probability": 0.9539794921875}, {"start": 815.91, "end": 816.51, "word": " هتطلع", "probability": 0.98662109375}, {"start": 816.51, "end": 816.73, "word": " بال", "probability": 0.9521484375}, {"start": 816.73, "end": 817.27, "word": " milligram", "probability": 0.2119140625}, {"start": 817.27, "end": 817.99, "word": " per", "probability": 0.92529296875}, {"start": 817.99, "end": 818.91, "word": " deciliter", "probability": 0.8103841145833334}, {"start": 818.91, "end": 819.65, "word": " أيضا", "probability": 0.8907877604166666}, {"start": 819.65, "end": 820.01, "word": " ال", "probability": 0.923828125}, {"start": 820.01, "end": 820.41, "word": " normal", "probability": 0.402587890625}, {"start": 820.41, "end": 820.97, "word": " range", "probability": 0.93505859375}, {"start": 820.97, "end": 822.21, "word": " للكوليسترول", "probability": 0.9219447544642857}, {"start": 822.21, "end": 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ننسى", "probability": 0.9693603515625}], "temperature": 1.0}, {"id": 37, "seek": 83778, "start": 828.88, "end": 837.78, "text": "إنه ال normal range من مختبر لمختبر بيكون مختلف حسب ال kit و حسب الشركة اللي بتصنع ال kit تمام؟", "tokens": [28814, 1863, 3224, 2423, 2710, 3613, 9154, 3714, 46456, 26890, 32767, 46456, 26890, 4724, 1829, 30544, 3714, 46456, 46538, 11331, 35457, 2423, 8260, 4032, 11331, 35457, 25124, 31747, 3660, 13672, 1829, 39894, 9381, 1863, 3615, 2423, 8260, 46811, 10943, 22807], "avg_logprob": -0.14233993320930294, "compression_ratio": 1.3275862068965518, "no_speech_prob": 6.794929504394531e-06, "words": [{"start": 828.88, "end": 829.46, "word": "إنه", "probability": 0.6578776041666666}, {"start": 829.46, "end": 829.94, "word": " ال", "probability": 0.95458984375}, {"start": 829.94, "end": 830.44, "word": " normal", "probability": 0.313720703125}, {"start": 830.44, "end": 830.9, "word": " range", "probability": 0.92578125}, {"start": 830.9, "end": 831.04, "word": " من", "probability": 0.98095703125}, {"start": 831.04, "end": 831.52, "word": " مختبر", "probability": 0.990234375}, {"start": 831.52, "end": 832.2, "word": " لمختبر", "probability": 0.9772135416666666}, {"start": 832.2, "end": 832.78, "word": " بيكون", "probability": 0.9441731770833334}, {"start": 832.78, "end": 833.46, "word": " مختلف", "probability": 0.9947916666666666}, {"start": 833.46, "end": 834.02, "word": " حسب", "probability": 0.95166015625}, {"start": 834.02, "end": 834.22, "word": " ال", "probability": 0.98291015625}, {"start": 834.22, "end": 834.58, "word": " kit", "probability": 0.736328125}, {"start": 834.58, "end": 834.86, "word": " و", "probability": 0.96435546875}, {"start": 834.86, "end": 835.18, "word": " حسب", "probability": 0.752685546875}, {"start": 835.18, "end": 835.68, "word": " الشركة", "probability": 0.9934895833333334}, {"start": 835.68, "end": 835.76, "word": " اللي", "probability": 0.89404296875}, {"start": 835.76, "end": 836.4, "word": " بتصنع", "probability": 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"word": " of", "probability": 0.9560546875}, {"start": 845.3, "end": 845.84, "word": " plasma", "probability": 0.2362060546875}, {"start": 845.84, "end": 846.92, "word": " lipoprotein", "probability": 0.9677734375}, {"start": 846.92, "end": 847.6, "word": " وهو", "probability": 0.851318359375}, {"start": 847.6, "end": 848.14, "word": " نوع", "probability": 0.8828125}, {"start": 848.14, "end": 848.5, "word": " من", "probability": 0.994140625}, {"start": 848.5, "end": 849.14, "word": " أنواع", "probability": 0.9485677083333334}, {"start": 849.14, "end": 850.02, "word": " نواقل", "probability": 0.92919921875}, {"start": 850.02, "end": 850.76, "word": " الدهون", "probability": 0.9664713541666666}, {"start": 850.76, "end": 851.68, "word": " وبشكل", "probability": 0.912109375}, {"start": 851.68, "end": 852.16, "word": " أساس", "probability": 0.9757486979166666}, {"start": 852.16, "end": 852.72, "word": " اتفاجنا", "probability": 0.77001953125}, {"start": 852.72, "end": 853.06, "word": " 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89165, "start": 862.43, "end": 891.65, "text": "الـ HDL يا جماعة بيسموه الـ Good Libo Protein الناقل الجيد للكلسترول بينما الـ LDL الـ Low Density Libo Protein برضه هذا ناقل للكلسترول لكن الـ LDL بيسموه الـ Bad Cholesterol الناقل السيء للكلسترول ليش؟ ليش الـ HDL بيسموه Good والـ LDL بيسموه Bad؟", "tokens": [6027, 39184, 12149, 43, 35186, 10874, 15042, 27884, 4724, 1829, 38251, 2407, 3224, 2423, 39184, 2205, 15834, 78, 43371, 259, 28239, 995, 4587, 1211, 25724, 25708, 24976, 28820, 14851, 2288, 12610, 49374, 15042, 2423, 39184, 33936, 43, 2423, 39184, 17078, 413, 6859, 15834, 78, 43371, 259, 4724, 43042, 3224, 23758, 8717, 995, 4587, 1211, 24976, 28820, 14851, 2288, 12610, 44381, 2423, 39184, 33936, 43, 4724, 1829, 38251, 2407, 3224, 2423, 39184, 11523, 761, 401, 21947, 28239, 995, 4587, 1211, 21136, 1829, 38207, 24976, 28820, 14851, 2288, 12610, 32239, 8592, 22807, 32239, 8592, 2423, 39184, 12149, 43, 4724, 1829, 38251, 2407, 3224, 2205, 16070, 39184, 33936, 43, 4724, 1829, 38251, 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ناقل", "probability": 0.9921875}, {"start": 876.71, "end": 877.91, "word": " للكلسترول", "probability": 0.93271484375}, {"start": 877.91, "end": 878.81, "word": " لكن", "probability": 0.94189453125}, {"start": 878.81, "end": 879.19, "word": " الـ", "probability": 0.8994140625}, {"start": 879.19, "end": 879.93, "word": " LDL", "probability": 0.957763671875}, {"start": 879.93, "end": 880.73, "word": " بيسموه", "probability": 0.982421875}, {"start": 880.73, "end": 880.91, "word": " الـ", "probability": 0.6558837890625}, {"start": 880.91, "end": 881.35, "word": " Bad", "probability": 0.93310546875}, {"start": 881.35, "end": 882.37, "word": " Cholesterol", "probability": 0.7491861979166666}, {"start": 882.37, "end": 883.29, "word": " الناقل", "probability": 0.96337890625}, {"start": 883.29, "end": 884.11, "word": " السيء", "probability": 0.9677734375}, {"start": 884.11, "end": 885.27, "word": " للكلسترول", "probability": 0.92822265625}, {"start": 885.27, "end": 887.17, "word": " ليش؟", 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الكوليسترول هذا الـ Low Density Lipoprotein هذا اللي بيوزع الكوليسترول من مكان التصنيع من الكبد لأنسجة الجسم و للخلايا اللي بدها الكوليسترول بس الـ HDL هذا الـ Good اللي كويس فيه إنه بيروح على الخلايا", "tokens": [28814, 8848, 1863, 47525, 8315, 8717, 5172, 16095, 36145, 2423, 39184, 33936, 43, 33251, 12610, 1829, 14851, 2288, 12610, 23758, 2423, 39184, 17078, 413, 6859, 27475, 404, 81, 1370, 259, 23758, 13672, 1829, 4724, 1829, 2407, 11622, 3615, 33251, 12610, 1829, 14851, 2288, 12610, 9154, 3714, 41361, 16712, 9381, 22653, 3615, 9154, 33251, 44510, 5296, 33456, 3794, 7435, 3660, 25724, 38251, 4032, 24976, 9778, 15040, 25528, 13672, 1829, 47525, 11296, 33251, 12610, 1829, 14851, 2288, 12610, 4724, 3794, 2423, 39184, 12149, 43, 23758, 2423, 39184, 2205, 13672, 1829, 9122, 45865, 3794, 8978, 3224, 36145, 3224, 4724, 13546, 2407, 5016, 15844, 33962, 15040, 25528], "avg_logprob": -0.17743389752621835, "compression_ratio": 1.8487804878048781, "no_speech_prob": 0.0, "words": [{"start": 994.56, "end": 994.9, "word": "إذن", "probability": 0.4989013671875}, {"start": 994.9, "end": 995.16, "word": " بدنا", "probability": 0.892333984375}, {"start": 995.16, "end": 995.62, "word": " نفهم", "probability": 0.9920247395833334}, {"start": 995.62, "end": 996.38, "word": " إن", "probability": 0.72265625}, {"start": 996.38, "end": 996.74, "word": " الـ", "probability": 0.93603515625}, {"start": 996.74, "end": 997.5, "word": " LDL", "probability": 0.869140625}, {"start": 997.5, "end": 998.5, "word": " الكوليسترول", "probability": 0.8595377604166666}, {"start": 998.5, "end": 999.04, "word": " هذا", "probability": 0.60986328125}, {"start": 999.04, "end": 999.54, "word": " الـ", "probability": 0.935791015625}, {"start": 999.54, "end": 999.8, "word": " Low", "probability": 0.423828125}, {"start": 999.8, "end": 1000.46, "word": " Density", "probability": 0.7139892578125}, {"start": 1000.46, "end": 1001.5, "word": " Lipoprotein", "probability": 0.7489013671875}, {"start": 1001.5, "end": 1002.06, "word": " هذا", "probability": 0.796875}, {"start": 1002.06, "end": 1002.38, "word": " اللي", "probability": 0.900634765625}, {"start": 1002.38, "end": 1003.24, "word": " بيوزع", "probability": 0.9369140625}, {"start": 1003.24, "end": 1004.42, "word": " الكوليسترول", "probability": 0.9671223958333334}, {"start": 1004.42, "end": 1004.94, "word": " من", "probability": 0.95703125}, {"start": 1004.94, "end": 1005.54, "word": " مكان", "probability": 0.993896484375}, {"start": 1005.54, "end": 1006.46, "word": " التصنيع", "probability": 0.91650390625}, {"start": 1006.46, "end": 1006.82, "word": " من", "probability": 0.93212890625}, {"start": 1006.82, "end": 1007.34, "word": " الكبد", "probability": 0.913818359375}, {"start": 1007.34, "end": 1009.44, "word": " لأنسجة", "probability": 0.8236328125}, {"start": 1009.44, "end": 1009.86, "word": " الجسم", "probability": 0.988037109375}, {"start": 1009.86, "end": 1010.1, "word": " و", "probability": 0.340576171875}, {"start": 1010.1, "end": 1010.7, "word": " للخلايا", "probability": 0.8992919921875}, {"start": 1010.7, "end": 1010.84, "word": " اللي", "probability": 0.95556640625}, {"start": 1010.84, "end": 1011.06, "word": " بدها", "probability": 0.80078125}, {"start": 1011.06, "end": 1011.74, "word": " الكوليسترول", "probability": 0.9208984375}, {"start": 1011.74, "end": 1012.46, "word": " بس", "probability": 0.854736328125}, {"start": 1012.46, "end": 1013.56, "word": " الـ", "probability": 0.798095703125}, {"start": 1013.56, "end": 1014.44, "word": " HDL", "probability": 0.6934814453125}, {"start": 1014.44, "end": 1015.06, "word": " هذا", "probability": 0.74755859375}, {"start": 1015.06, "end": 1015.78, "word": " الـ", "probability": 0.915771484375}, {"start": 1015.78, "end": 1016.24, "word": " Good", "probability": 0.490234375}, {"start": 1016.24, "end": 1016.56, "word": " اللي", "probability": 0.970458984375}, {"start": 1016.56, "end": 1017.16, "word": " كويس", "probability": 0.9845377604166666}, {"start": 1017.16, "end": 1017.6, "word": " فيه", "probability": 0.98681640625}, {"start": 1017.6, "end": 1018.42, "word": " إنه", "probability": 0.8330078125}, {"start": 1018.42, "end": 1019.18, "word": " بيروح", "probability": 0.978515625}, {"start": 1019.18, "end": 1019.54, "word": " على", "probability": 0.93994140625}, {"start": 1019.54, "end": 1020.2, "word": " الخلايا", "probability": 0.98486328125}], "temperature": 1.0}, {"id": 45, "seek": 103742, "start": 1020.48, "end": 1037.42, "text": "بيحمل فائد الكوليسترول، الفائد عن حاجتها، بياخده، بيلتقطه، و بيمشي بشكل reverse عكسي لفوق، لحد ما يصلّى الكبد، و بيودّي الفائد لكبد، عشان الكبد يتصرف بهذا الفائد، تمام؟", "tokens": [21292, 35571, 1211, 6156, 16373, 3215, 33251, 12610, 1829, 14851, 2288, 12610, 12399, 27188, 16373, 3215, 18871, 11331, 26108, 2655, 11296, 12399, 4724, 1829, 47283, 3215, 3224, 12399, 4724, 26895, 2655, 47432, 3224, 12399, 4032, 4724, 32640, 8592, 1829, 4724, 8592, 28820, 9943, 6225, 4117, 3794, 1829, 5296, 5172, 30543, 12399, 5296, 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{"start": 1025.66, "end": 1026.7, "word": " بيلتقطه،", "probability": 0.7596028645833334}, {"start": 1026.7, "end": 1026.78, "word": " و", "probability": 0.80322265625}, {"start": 1026.78, "end": 1027.26, "word": " بيمشي", "probability": 0.8865966796875}, {"start": 1027.26, "end": 1027.74, "word": " بشكل", "probability": 0.9886067708333334}, {"start": 1027.74, "end": 1028.38, "word": " reverse", "probability": 0.6396484375}, {"start": 1028.38, "end": 1028.98, "word": " عكسي", "probability": 0.956298828125}, {"start": 1028.98, "end": 1029.7, "word": " لفوق،", "probability": 0.88232421875}, {"start": 1029.7, "end": 1030.04, "word": " لحد", "probability": 0.9677734375}, {"start": 1030.04, "end": 1030.18, "word": " ما", "probability": 0.98876953125}, {"start": 1030.18, "end": 1030.88, "word": " يصلّى", "probability": 0.65966796875}, {"start": 1030.88, "end": 1031.9, "word": " الكبد،", "probability": 0.8697916666666666}, {"start": 1031.9, "end": 1032.0, "word": " و", "probability": 0.95849609375}, {"start": 1032.0, "end": 1032.74, "word": " بيودّي", "probability": 0.8171875}, {"start": 1032.74, "end": 1033.18, "word": " الفائد", "probability": 0.9772135416666666}, {"start": 1033.18, "end": 1033.86, "word": " لكبد،", "probability": 0.61346435546875}, {"start": 1033.86, "end": 1034.16, "word": " عشان", "probability": 0.9163411458333334}, {"start": 1034.16, "end": 1034.52, "word": " الكبد", "probability": 0.901123046875}, {"start": 1034.52, "end": 1035.18, "word": " يتصرف", "probability": 0.9940185546875}, {"start": 1035.18, "end": 1035.74, "word": " بهذا", "probability": 0.9306640625}, {"start": 1035.74, "end": 1036.88, "word": " الفائد،", "probability": 0.9132080078125}, {"start": 1036.88, "end": 1037.42, "word": " تمام؟", "probability": 0.9698893229166666}], "temperature": 1.0}, {"id": 46, "seek": 106134, "start": 1038.27, "end": 1061.35, "text": "it is composed of تركيبة الـ HDL قولنا عامل زي الكورة من برا عبارة عن البروتين هو أصلا عبارة عن البروتين الماقل 50% من تركيبته البروتين وحكينا برضه من برا إغشاءه فيه phospholipid و 25% من تركيبه فيه phospholipid", "tokens": [270, 307, 18204, 295, 6055, 31747, 1829, 49401, 2423, 39184, 12149, 43, 12174, 12610, 8315, 6225, 10943, 1211, 30767, 1829, 33251, 13063, 3660, 9154, 4724, 23557, 6225, 3555, 9640, 3660, 18871, 2423, 26890, 35473, 9957, 31439, 5551, 9381, 15040, 6225, 3555, 9640, 3660, 18871, 2423, 26890, 35473, 9957, 9673, 995, 4587, 1211, 2625, 4, 9154, 6055, 31747, 1829, 3555, 47395, 2423, 26890, 35473, 9957, 4032, 5016, 4117, 1829, 8315, 4724, 43042, 3224, 9154, 4724, 23557, 11933, 17082, 8592, 16606, 3224, 8978, 3224, 19775, 401, 647, 327, 4032, 3552, 4, 9154, 6055, 31747, 1829, 3555, 3224, 8978, 3224, 19775, 401, 647, 327], "avg_logprob": -0.13549325308379004, "compression_ratio": 1.8021390374331552, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 1038.27, "end": 1038.53, "word": "it", "probability": 0.37841796875}, {"start": 1038.53, "end": 1038.81, "word": " is", "probability": 0.83740234375}, {"start": 1038.81, "end": 1039.31, "word": " composed", "probability": 0.955078125}, {"start": 1039.31, "end": 1039.81, "word": " of", "probability": 0.9755859375}, {"start": 1039.81, "end": 1040.97, "word": " تركيبة", "probability": 0.9017333984375}, {"start": 1040.97, "end": 1041.33, "word": " الـ", "probability": 0.944580078125}, {"start": 1041.33, "end": 1041.83, "word": " HDL", "probability": 0.7568359375}, {"start": 1041.83, "end": 1042.15, "word": " قولنا", "probability": 0.802734375}, {"start": 1042.15, "end": 1042.49, "word": " عامل", "probability": 0.9807942708333334}, {"start": 1042.49, "end": 1042.79, "word": " زي", "probability": 0.970703125}, {"start": 1042.79, "end": 1043.41, "word": " الكورة", "probability": 0.9832356770833334}, {"start": 1043.41, "end": 1044.03, "word": " من", "probability": 0.91650390625}, {"start": 1044.03, "end": 1044.65, "word": " برا", "probability": 0.75341796875}, {"start": 1044.65, "end": 1045.31, "word": " عبارة", "probability": 0.8870849609375}, {"start": 1045.31, "end": 1045.47, "word": " عن", "probability": 0.99462890625}, {"start": 1045.47, "end": 1046.05, "word": " البروتين", "probability": 0.8165283203125}, {"start": 1046.05, "end": 1046.47, "word": " هو", "probability": 0.845703125}, {"start": 1046.47, "end": 1047.03, "word": " أصلا", "probability": 0.8138020833333334}, {"start": 1047.03, "end": 1047.61, "word": " عبارة", "probability": 0.9642333984375}, {"start": 1047.61, "end": 1047.77, "word": " عن", "probability": 0.99609375}, {"start": 1047.77, "end": 1048.29, "word": " البروتين", "probability": 0.975341796875}, {"start": 1048.29, "end": 1048.79, "word": " الماقل", "probability": 0.883544921875}, {"start": 1048.79, "end": 1049.65, "word": " 50", "probability": 0.403076171875}, {"start": 1049.65, "end": 1050.09, "word": "%", "probability": 0.95556640625}, {"start": 1050.09, "end": 1050.61, "word": " من", "probability": 0.98583984375}, {"start": 1050.61, "end": 1051.57, "word": " تركيبته", "probability": 0.98291015625}, {"start": 1051.57, "end": 1052.51, "word": " البروتين", "probability": 0.95458984375}, {"start": 1052.51, "end": 1053.39, "word": " وحكينا", "probability": 0.923046875}, {"start": 1053.39, "end": 1053.79, "word": " برضه", "probability": 0.9212239583333334}, {"start": 1053.79, "end": 1054.03, "word": " من", "probability": 0.9697265625}, {"start": 1054.03, "end": 1054.55, "word": " برا", "probability": 0.9443359375}, {"start": 1054.55, "end": 1055.51, "word": " إغشاءه", "probability": 0.740478515625}, {"start": 1055.51, "end": 1055.75, "word": " فيه", "probability": 0.97412109375}, {"start": 1055.75, "end": 1056.49, "word": " phospholipid", "probability": 0.80328369140625}, {"start": 1056.49, "end": 1056.97, "word": " و", "probability": 0.9638671875}, {"start": 1056.97, "end": 1057.35, "word": " 25", "probability": 0.496337890625}, {"start": 1057.35, "end": 1058.21, "word": "%", "probability": 0.9873046875}, {"start": 1058.21, "end": 1058.69, "word": " من", "probability": 0.9931640625}, {"start": 1058.69, "end": 1059.59, "word": " تركيبه", "probability": 0.99140625}, {"start": 1059.59, "end": 1060.33, "word": " فيه", "probability": 0.993408203125}, {"start": 1060.33, "end": 1061.35, "word": " phospholipid", "probability": 0.8990478515625}], "temperature": 1.0}, {"id": 47, "seek": 108378, "start": 1062.16, "end": 1083.78, "text": "و جوه إذا حكينا التركيبة الخارجية protein و phospholipid و جوه بيشيل الكوليسترول اللي بده يعني ياخده من الأنسجة و الخلايا و يوديه للـ liver عشرين في المية من الكوليسترول يتم وضعه بداخل هذا ال protein و نقله إلى الكبد", "tokens": [2407, 10874, 2407, 3224, 11933, 15730, 11331, 4117, 1829, 8315, 16712, 31747, 1829, 49401, 33962, 9640, 7435, 10632, 7944, 4032, 19775, 401, 647, 327, 4032, 10874, 2407, 3224, 4724, 1829, 8592, 26895, 33251, 12610, 1829, 14851, 2288, 12610, 13672, 1829, 47525, 3224, 37495, 22653, 7251, 47283, 3215, 3224, 9154, 16247, 1863, 3794, 7435, 3660, 4032, 33962, 15040, 25528, 4032, 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"word": " بيستخدموها", "probability": 0.9773995535714286}, {"start": 1185.61, "end": 1186.31, "word": " اكتر", "probability": 0.81005859375}, {"start": 1186.31, "end": 1187.53, "word": " طبعا", "probability": 0.967529296875}, {"start": 1187.53, "end": 1188.51, "word": " الـ", "probability": 0.693359375}, {"start": 1188.51, "end": 1189.33, "word": " Liboprotein", "probability": 0.6681640625}, {"start": 1189.33, "end": 1189.97, "word": " لواق", "probability": 0.7001953125}, {"start": 1189.97, "end": 1190.85, "word": " الدهون", "probability": 0.9143880208333334}, {"start": 1190.85, "end": 1191.43, "word": " أربعة", "probability": 0.8230794270833334}], "temperature": 1.0}, {"id": 53, "seek": 121724, "start": 1191.74, "end": 1217.24, "text": "الـ Kylomicron الـ HDL والـ LDL والـ VLDL هدولا كلهم بيكونوا موجودين في البلازمة تبع الإنسان أو في السيرام تاخد عينة البلازمة أو السيرام وبتحطيها في جهاز centrifuge اسمه Ultra Centrifuge هذا الجهاز هيفصل العينة إلى أربع طبقات تمام؟", "tokens": [6027, 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"compression_ratio": 0.961038961038961, "no_speech_prob": 0.0, "words": [{"start": 1346.74, "end": 1347.0, "word": "الـ", "probability": 0.5086669921875}, {"start": 1347.0, "end": 1348.08, "word": " Polyacrylamide", "probability": 0.8240234375}, {"start": 1348.08, "end": 1348.42, "word": " Gel", "probability": 0.427978515625}, {"start": 1348.42, "end": 1349.64, "word": " Electrophoresis", "probability": 0.9549560546875}, {"start": 1349.64, "end": 1350.32, "word": " الفصل", "probability": 0.73974609375}, {"start": 1350.32, "end": 1350.86, "word": " الجاي", "probability": 0.67578125}, {"start": 1350.86, "end": 1352.56, "word": " هناخد", "probability": 0.76092529296875}], "temperature": 1.0}, {"id": 60, "seek": 137941, "start": 1352.93, "end": 1379.41, "text": "كيف ممكن أفصل الليبو بروتين الأربعة نواق الدهون الأربعة على الـ Polyacrylamide Gel هتشوفوا يا جماعة الأربع بندات الـ HDL و الـ LDL و الـ VLDL و الـ Kilo Micron و بقدر بعد ما أفصلهم أحسب تركيز كل واحد على حدة من خلال جهاز اسمه 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بالتفصيل", "probability": 0.939453125}, {"start": 1378.57, "end": 1379.01, "word": " الفصل", "probability": 0.859130859375}, {"start": 1379.01, "end": 1379.41, "word": " الجاي", "probability": 0.645263671875}], "temperature": 1.0}, {"id": 61, "seek": 140300, "start": 1380.42, "end": 1403.0, "text": "الـ Precipitation في كتات و هذه الكتات المعتمدة عندنا في المختبر ان انا بفحص تركيز الـ HDL بطريقة الـ Precipitation الطريقة بتعتمد على اني باضيف اني باضيف مادة على الـ Serum تبع المريض هذه المادة بتعمل الـ Precipitation ترثيب", "tokens": [6027, 39184, 6001, 11371, 4614, 8978, 9122, 2655, 9307, 4032, 29538, 33251, 2655, 9307, 9673, 34268, 2304, 41891, 43242, 8315, 8978, 9673, 46456, 26890, 16472, 1975, 8315, 4724, 5172, 5016, 9381, 6055, 31747, 1829, 11622, 2423, 39184, 12149, 43, 4724, 9566, 16572, 28671, 2423, 39184, 6001, 11371, 4614, 41950, 16572, 28671, 39894, 34268, 2304, 3215, 15844, 16472, 1829, 4724, 46958, 33911, 16472, 1829, 4724, 46958, 33911, 3714, 18513, 3660, 15844, 2423, 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"probability": 0.93359375}, {"start": 1432.92, "end": 1433.22, "word": " to", "probability": 0.93896484375}, {"start": 1433.22, "end": 1434.24, "word": " precipitate", "probability": 0.95654296875}, {"start": 1434.24, "end": 1434.5, "word": " the", "probability": 0.366455078125}, {"start": 1434.5, "end": 1435.36, "word": " selectivity", "probability": 0.959716796875}, {"start": 1435.36, "end": 1435.8, "word": " of", "probability": 0.367919921875}, {"start": 1435.8, "end": 1435.86, "word": " the", "probability": 0.658203125}, {"start": 1435.86, "end": 1436.24, "word": " major", "probability": 0.79736328125}, {"start": 1436.24, "end": 1437.12, "word": " lipoprotein", "probability": 0.95224609375}, {"start": 1437.12, "end": 1437.9, "word": " fractions", "probability": 0.7021484375}, {"start": 1437.9, "end": 1438.52, "word": " except", "probability": 0.8740234375}, {"start": 1438.52, "end": 1439.26, "word": " HDL", "probability": 0.90625}, {"start": 1439.26, "end": 1439.92, "word": " 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"end": 1452.03, "word": " عن", "probability": 0.9970703125}, {"start": 1452.03, "end": 1453.19, "word": " الانتيجينات", "probability": 0.7605678013392857}, {"start": 1453.19, "end": 1453.99, "word": " فلو", "probability": 0.96875}, {"start": 1453.99, "end": 1454.39, "word": " جبت", "probability": 0.9619140625}, {"start": 1454.39, "end": 1454.71, "word": " انا", "probability": 0.784423828125}, {"start": 1454.71, "end": 1455.47, "word": " antibodies", "probability": 0.84716796875}, {"start": 1455.47, "end": 1456.23, "word": " مثلا", "probability": 0.921142578125}, {"start": 1456.23, "end": 1456.73, "word": " هنا", "probability": 0.9501953125}, {"start": 1456.73, "end": 1457.25, "word": " بيحكيلك", "probability": 0.822509765625}, {"start": 1457.25, "end": 1457.51, "word": " بدي", "probability": 0.68408203125}, {"start": 1457.51, "end": 1457.95, "word": " اقيس", "probability": 0.8203125}, {"start": 1457.95, "end": 1458.11, "word": " ال", "probability": 0.98779296875}, {"start": 1458.11, "end": 1458.87, "word": " HDL", "probability": 0.691162109375}, {"start": 1458.87, "end": 1459.51, "word": " لو", "probability": 0.86328125}, {"start": 1459.51, "end": 1459.93, "word": " جبت", "probability": 0.9931640625}, {"start": 1459.93, "end": 1460.61, "word": " antibodies", "probability": 0.9306640625}], "temperature": 1.0}, {"id": 65, "seek": 148669, "start": 1461.91, "end": 1486.69, "text": "هذا الـ Antibody مثلا جبت Antibody ضد الـ LDL وAntibody ضد الـ VLDL وAntibody ضد الـ Kilomicron او اذا تمام المهم Antibodies بجيبها لكل الـ lipoprotein مع هذا الـ lipoprotein اللي انا بدي اقيسه بخليه free باخده و بقيسه تمام؟", "tokens": [3224, 15730, 2423, 39184, 5130, 897, 843, 50113, 15040, 10874, 3555, 2655, 5130, 897, 843, 48812, 3215, 2423, 39184, 33936, 43, 4032, 35807, 897, 843, 48812, 3215, 2423, 39184, 691, 23704, 43, 4032, 35807, 897, 843, 48812, 3215, 2423, 39184, 23912, 21401, 2044, 1975, 2407, 1975, 15730, 46811, 10943, 9673, 16095, 5130, 897, 6087, 4724, 7435, 1829, 3555, 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0.904052734375}, {"start": 1481.03, "end": 1481.31, "word": " انا", "probability": 0.830322265625}, {"start": 1481.31, "end": 1481.73, "word": " بدي", "probability": 0.75830078125}, {"start": 1481.73, "end": 1482.45, "word": " اقيسه", "probability": 0.77783203125}, {"start": 1482.45, "end": 1483.63, "word": " بخليه", "probability": 0.9451904296875}, {"start": 1483.63, "end": 1484.09, "word": " free", "probability": 0.3671875}, {"start": 1484.09, "end": 1484.99, "word": " باخده", "probability": 0.9512939453125}, {"start": 1484.99, "end": 1485.07, "word": " و", "probability": 0.65234375}, {"start": 1485.07, "end": 1486.01, "word": " بقيسه", "probability": 0.9739990234375}, {"start": 1486.01, "end": 1486.69, "word": " تمام؟", "probability": 0.9000651041666666}], "temperature": 1.0}, {"id": 66, "seek": 150551, "start": 1487.55, "end": 1505.51, "text": "أو العكس أروح أجيب antibody ضد مثلا الـHDL اللي أنا بدي أقيسه برتبط معاه ما هو الـHDL-antigen مع الـantibody بعطيني الـcomplex بالإليزا بالطرق المنعية اللي أنتوا عارفينها بيتم قياس تركيز الـHDL", "tokens": [10721, 2407, 18863, 4117, 3794, 5551, 32887, 5016, 5551, 7435, 1829, 3555, 34507, 48812, 3215, 50113, 15040, 2423, 39184, 39, 35, 43, 13672, 1829, 41850, 4724, 16254, 5551, 38436, 3794, 3224, 4724, 43500, 3555, 9566, 20449, 40294, 19446, 31439, 2423, 39184, 22859, 43, 12, 394, 3213, 20449, 2423, 39184, 394, 897, 843, 45030, 9566, 9957, 1829, 2423, 39184, 1112, 18945, 20666, 28814, 20292, 11622, 995, 20666, 9566, 2288, 4587, 9673, 1863, 3615, 10632, 13672, 1829, 14739, 2655, 14407, 6225, 9640, 5172, 9957, 11296, 4724, 36081, 2304, 12174, 25528, 3794, 6055, 31747, 1829, 11622, 2423, 39184, 22859, 43], "avg_logprob": -0.18973214863514415, "compression_ratio": 1.5879396984924623, "no_speech_prob": 0.0, "words": [{"start": 1487.55, "end": 1487.83, "word": "أو", "probability": 0.9541015625}, {"start": 1487.83, "end": 1488.47, "word": " العكس", "probability": 0.9020182291666666}, {"start": 1488.47, "end": 1489.03, "word": " أروح", "probability": 0.718994140625}, {"start": 1489.03, "end": 1489.49, "word": " أجيب", "probability": 0.9837646484375}, {"start": 1489.49, "end": 1490.21, "word": " antibody", "probability": 0.401123046875}, {"start": 1490.21, "end": 1491.49, "word": " ضد", "probability": 0.7159423828125}, {"start": 1491.49, "end": 1492.09, "word": " مثلا", "probability": 0.855224609375}, {"start": 1492.09, "end": 1493.23, "word": " الـHDL", "probability": 0.839990234375}, {"start": 1493.23, "end": 1493.45, "word": " اللي", "probability": 0.8857421875}, {"start": 1493.45, "end": 1493.61, "word": " أنا", "probability": 0.7890625}, {"start": 1493.61, "end": 1493.89, "word": " بدي", "probability": 0.832275390625}, {"start": 1493.89, "end": 1494.51, "word": " أقيسه", "probability": 0.8892822265625}, {"start": 1494.51, "end": 1495.39, "word": " برتبط", "probability": 0.8958740234375}, {"start": 1495.39, "end": 1495.81, "word": " معاه", "probability": 0.962890625}, {"start": 1495.81, "end": 1495.95, "word": " ما", "probability": 0.66015625}, {"start": 1495.95, "end": 1496.05, "word": " هو", "probability": 0.732421875}, {"start": 1496.05, "end": 1496.79, "word": " الـHDL", "probability": 0.874267578125}, {"start": 1496.79, "end": 1497.39, "word": "-antigen", "probability": 0.7572428385416666}, {"start": 1497.39, "end": 1497.85, "word": " مع", "probability": 0.94970703125}, {"start": 1497.85, "end": 1498.53, "word": " الـantibody", "probability": 0.91552734375}, {"start": 1498.53, "end": 1498.97, "word": " بعطيني", "probability": 0.69732666015625}, {"start": 1498.97, "end": 1499.57, "word": " الـcomplex", "probability": 0.66943359375}, {"start": 1499.57, "end": 1500.65, "word": " بالإليزا", "probability": 0.747412109375}, {"start": 1500.65, "end": 1501.07, "word": " بالطرق", "probability": 0.82513427734375}, {"start": 1501.07, "end": 1501.59, "word": " المنعية", "probability": 0.86627197265625}, {"start": 1501.59, "end": 1501.75, "word": " اللي", "probability": 0.968994140625}, {"start": 1501.75, "end": 1502.09, "word": " أنتوا", "probability": 0.78857421875}, {"start": 1502.09, "end": 1502.77, "word": " عارفينها", "probability": 0.99296875}, {"start": 1502.77, "end": 1503.57, "word": " بيتم", "probability": 0.8194986979166666}, {"start": 1503.57, "end": 1504.15, "word": " قياس", "probability": 0.9444986979166666}, {"start": 1504.15, "end": 1504.69, "word": " تركيز", "probability": 0.988525390625}, {"start": 1504.69, "end": 1505.51, "word": " الـHDL", "probability": 0.92333984375}], "temperature": 1.0}, {"id": 67, "seek": 152312, "start": 1506.38, "end": 1523.12, "text": "هنا إيش حاكيه إن Antibodies against human lipoproteins are used to form antigen-antibody complexes with LDL, VLDL and chylomicron يعني جاب Antibody ضد الليبوبروتين هذه التلاتة", "tokens": [3224, 8315, 11933, 1829, 8592, 11331, 995, 4117, 1829, 3224, 36145, 5130, 897, 6087, 1970, 1952, 8280, 404, 81, 1370, 1292, 366, 1143, 281, 1254, 2511, 3213, 12, 394, 897, 843, 43676, 365, 33936, 43, 11, 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1512.22, "word": " are", "probability": 0.755859375}, {"start": 1512.22, "end": 1512.62, "word": " used", "probability": 0.93115234375}, {"start": 1512.62, "end": 1512.88, "word": " to", "probability": 0.97607421875}, {"start": 1512.88, "end": 1513.2, "word": " form", "probability": 0.9306640625}, {"start": 1513.2, "end": 1513.86, "word": " antigen", "probability": 0.790771484375}, {"start": 1513.86, "end": 1514.5, "word": "-antibody", "probability": 0.8663330078125}, {"start": 1514.5, "end": 1515.3, "word": " complexes", "probability": 0.86083984375}, {"start": 1515.3, "end": 1515.96, "word": " with", "probability": 0.90283203125}, {"start": 1515.96, "end": 1516.62, "word": " LDL,", "probability": 0.957275390625}, {"start": 1516.76, "end": 1517.32, "word": " VLDL", "probability": 0.93212890625}, {"start": 1517.32, "end": 1517.54, "word": " and", "probability": 0.7275390625}, {"start": 1517.54, "end": 1518.38, "word": " chylomicron", "probability": 0.8251953125}, {"start": 1518.38, "end": 1519.02, "word": " يعني", "probability": 0.8916015625}, {"start": 1519.02, "end": 1519.34, "word": " جاب", "probability": 0.95458984375}, {"start": 1519.34, "end": 1520.12, "word": " Antibody", "probability": 0.7390950520833334}, {"start": 1520.12, "end": 1520.76, "word": " ضد", "probability": 0.993896484375}, {"start": 1520.76, "end": 1521.96, "word": " الليبوبروتين", "probability": 0.7908761160714286}, {"start": 1521.96, "end": 1522.48, "word": " هذه", "probability": 0.8115234375}, {"start": 1522.48, "end": 1523.12, "word": " التلاتة", "probability": 0.9691162109375}], "temperature": 1.0}, {"id": 68, "seek": 154629, "start": 1523.71, "end": 1546.29, "text": "in a way that only فقط الـ HDL الـ selectivity determined فقط الـ HDL بيضلوا free و بقيسوا بالطريقة العادية عادة بتكون enzymatic method تمام؟ ال kit تبعه لما نرجع الجامعة هنقرأ ال kit ال pamphlet تبعته و نشوف قلية شغله", "tokens": [259, 257, 636, 300, 787, 6156, 47432, 2423, 39184, 12149, 43, 2423, 39184, 3048, 4253, 9540, 6156, 47432, 2423, 39184, 12149, 43, 4724, 1829, 11242, 1211, 14407, 1737, 4032, 4724, 38436, 3794, 14407, 20666, 9566, 16572, 28671, 18863, 18513, 10632, 6225, 18513, 3660, 39894, 30544, 16272, 25915, 3170, 46811, 10943, 22807, 2423, 8260, 6055, 3555, 3615, 3224, 5296, 15042, 8717, 47341, 3615, 25724, 10943, 27884, 8032, 1863, 4587, 2288, 10721, 2423, 8260, 2423, 30738, 950, 2631, 6055, 3555, 34268, 3224, 4032, 8717, 8592, 38688, 12174, 1211, 10632, 13412, 17082, 43761], "avg_logprob": -0.16577952838206028, "compression_ratio": 1.4570135746606334, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1523.71, "end": 1524.01, "word": "in", "probability": 0.5458984375}, {"start": 1524.01, "end": 1524.29, "word": " a", "probability": 0.98388671875}, {"start": 1524.29, "end": 1524.63, "word": " way", "probability": 0.97119140625}, {"start": 1524.63, "end": 1525.09, "word": " that", "probability": 0.92919921875}, {"start": 1525.09, "end": 1525.93, "word": " only", "probability": 0.84228515625}, {"start": 1525.93, "end": 1526.75, "word": " فقط", "probability": 0.968994140625}, {"start": 1526.75, "end": 1527.23, "word": " الـ", "probability": 0.975830078125}, {"start": 1527.23, "end": 1528.05, "word": " HDL", "probability": 0.6749267578125}, {"start": 1528.05, "end": 1528.55, "word": " الـ", "probability": 0.75146484375}, {"start": 1528.55, "end": 1529.49, "word": " selectivity", "probability": 0.788330078125}, {"start": 1529.49, "end": 1530.53, "word": " determined", "probability": 0.7021484375}, {"start": 1530.53, "end": 1530.93, "word": " فقط", "probability": 0.9775390625}, {"start": 1530.93, "end": 1531.19, "word": " الـ", "probability": 0.968017578125}, {"start": 1531.19, "end": 1531.75, "word": " HDL", "probability": 0.883056640625}, {"start": 1531.75, "end": 1532.43, "word": " بيضلوا", "probability": 0.74970703125}, {"start": 1532.43, "end": 1532.89, "word": " free", "probability": 0.76806640625}, {"start": 1532.89, "end": 1533.55, "word": " و", "probability": 0.505859375}, {"start": 1533.55, "end": 1534.49, "word": " بقيسوا", "probability": 0.8277587890625}, {"start": 1534.49, "end": 1535.29, "word": " بالطريقة", "probability": 0.9725341796875}, {"start": 1535.29, "end": 1536.25, "word": " العادية", "probability": 0.9947916666666666}, {"start": 1536.25, "end": 1537.77, "word": " عادة", "probability": 0.9833984375}, {"start": 1537.77, "end": 1538.19, "word": " بتكون", "probability": 0.901123046875}, {"start": 1538.19, "end": 1539.03, "word": " enzymatic", "probability": 0.9619140625}, {"start": 1539.03, "end": 1539.53, "word": " method", "probability": 0.9775390625}, {"start": 1539.53, "end": 1540.41, "word": " تمام؟", "probability": 0.7063802083333334}, {"start": 1540.41, "end": 1540.55, "word": " ال", "probability": 0.87109375}, {"start": 1540.55, "end": 1540.75, "word": " kit", "probability": 0.451171875}, {"start": 1540.75, "end": 1541.31, "word": " تبعه", "probability": 0.9171142578125}, {"start": 1541.31, "end": 1541.53, "word": " لما", "probability": 0.872802734375}, {"start": 1541.53, "end": 1541.95, "word": " نرجع", "probability": 0.9645182291666666}, {"start": 1541.95, "end": 1542.51, "word": " الجامعة", "probability": 0.9361979166666666}, {"start": 1542.51, "end": 1543.15, "word": " هنقرأ", "probability": 0.92607421875}, {"start": 1543.15, "end": 1543.31, "word": " ال", "probability": 0.97509765625}, {"start": 1543.31, "end": 1543.55, "word": " kit", "probability": 0.66162109375}, {"start": 1543.55, "end": 1543.75, "word": " ال", "probability": 0.78125}, {"start": 1543.75, "end": 1544.23, "word": " pamphlet", "probability": 0.8098958333333334}, {"start": 1544.23, "end": 1544.81, "word": " تبعته", "probability": 0.953369140625}, {"start": 1544.81, "end": 1544.93, "word": " و", "probability": 0.9716796875}, {"start": 1544.93, "end": 1545.27, "word": " نشوف", "probability": 0.8994140625}, {"start": 1545.27, "end": 1545.79, "word": " قلية", "probability": 0.586181640625}, {"start": 1545.79, "end": 1546.29, "word": " شغله", "probability": 0.97900390625}], "temperature": 1.0}, {"id": 69, "seek": 157141, "start": 1551.15, "end": 1571.41, "text": "لـ precipitation methods حكينا in the plasma كوليسترول is transported by three ليبوبروتين في البلازمة الكوليسترول ينقل عن طريق تلت نواقل الـ high-density ليبوبروتين الـ HDL والـ low-density ليبوبروتين الـ LDL والـ very low-density ليبوبروتين", "tokens": [1211, 39184, 37662, 7150, 11331, 4117, 1829, 8315, 294, 264, 22564, 9122, 12610, 1829, 14851, 2288, 12610, 307, 29373, 538, 1045, 32239, 3555, 2407, 26890, 35473, 9957, 8978, 29739, 1211, 31377, 2304, 3660, 33251, 12610, 1829, 14851, 2288, 12610, 7251, 1863, 4587, 1211, 18871, 23032, 16572, 4587, 6055, 1211, 2655, 8717, 14407, 4587, 1211, 2423, 39184, 1090, 12, 67, 6859, 32239, 3555, 2407, 26890, 35473, 9957, 2423, 39184, 12149, 43, 16070, 39184, 2295, 12, 67, 6859, 32239, 3555, 2407, 26890, 35473, 9957, 2423, 39184, 33936, 43, 16070, 39184, 588, 2295, 12, 67, 6859, 32239, 3555, 2407, 26890, 35473, 9957], "avg_logprob": -0.2087499976158142, "compression_ratio": 1.8195876288659794, "no_speech_prob": 0.0, "words": [{"start": 1551.15, "end": 1551.43, "word": "لـ", "probability": 0.5672607421875}, {"start": 1551.43, "end": 1551.85, "word": " precipitation", "probability": 0.412109375}, {"start": 1551.85, "end": 1552.81, "word": " methods", "probability": 0.716796875}, {"start": 1552.81, "end": 1553.49, "word": " حكينا", "probability": 0.9801025390625}, {"start": 1553.49, "end": 1553.97, "word": " in", "probability": 0.2088623046875}, {"start": 1553.97, "end": 1554.15, "word": " the", "probability": 0.89599609375}, {"start": 1554.15, "end": 1554.67, "word": " plasma", "probability": 0.8203125}, {"start": 1554.67, "end": 1555.65, "word": " كوليسترول", "probability": 0.8525187174479166}, {"start": 1555.65, "end": 1555.95, "word": " is", "probability": 0.41357421875}, {"start": 1555.95, "end": 1556.75, "word": " transported", "probability": 0.96337890625}, {"start": 1556.75, "end": 1557.11, "word": " by", "probability": 0.9267578125}, {"start": 1557.11, "end": 1557.45, "word": " three", "probability": 0.56787109375}, {"start": 1557.45, "end": 1558.29, "word": " ليبوبروتين", "probability": 0.8140462239583334}, {"start": 1558.29, "end": 1558.57, "word": " في", "probability": 0.84814453125}, {"start": 1558.57, "end": 1559.13, "word": " البلازمة", "probability": 0.73193359375}, {"start": 1559.13, "end": 1559.89, "word": " الكوليسترول", "probability": 0.9124348958333334}, {"start": 1559.89, "end": 1560.89, "word": " ينقل", "probability": 0.9232177734375}, {"start": 1560.89, "end": 1561.35, "word": " عن", "probability": 0.98486328125}, {"start": 1561.35, "end": 1561.89, "word": " طريق", "probability": 0.9928385416666666}, {"start": 1561.89, "end": 1562.31, "word": " تلت", "probability": 0.9083658854166666}, {"start": 1562.31, "end": 1563.11, "word": " نواقل", "probability": 0.9580078125}, {"start": 1563.11, "end": 1563.89, "word": " الـ", "probability": 0.88818359375}, {"start": 1563.89, "end": 1564.01, "word": " high", "probability": 0.38623046875}, {"start": 1564.01, "end": 1564.63, "word": "-density", "probability": 0.7177734375}, {"start": 1564.63, "end": 1565.41, "word": " ليبوبروتين", "probability": 0.9599609375}, {"start": 1565.41, "end": 1565.63, "word": " الـ", "probability": 0.764892578125}, {"start": 1565.63, "end": 1566.25, "word": " HDL", "probability": 0.787109375}, {"start": 1566.25, "end": 1566.65, "word": " والـ", "probability": 0.4736328125}, {"start": 1566.65, "end": 1566.79, "word": " low", "probability": 0.92822265625}, {"start": 1566.79, "end": 1567.27, "word": "-density", "probability": 0.85595703125}, {"start": 1567.27, "end": 1568.19, "word": " ليبوبروتين", "probability": 0.983154296875}, {"start": 1568.19, "end": 1568.43, "word": " الـ", "probability": 0.922119140625}, {"start": 1568.43, "end": 1569.05, "word": " LDL", "probability": 0.9697265625}, {"start": 1569.05, "end": 1569.55, "word": " والـ", "probability": 0.701904296875}, {"start": 1569.55, "end": 1569.73, "word": " very", "probability": 0.80126953125}, {"start": 1569.73, "end": 1570.03, "word": " low", "probability": 0.751953125}, {"start": 1570.03, "end": 1570.51, "word": "-density", "probability": 0.8264973958333334}, {"start": 1570.51, "end": 1571.41, "word": " ليبوبروتين", "probability": 0.9847819010416666}], "temperature": 1.0}, {"id": 70, "seek": 158332, "start": 1571.8, "end": 1583.32, "text": "قلنا إن الـ VLDL هذا الـ Very low density lipoprotein بنقل لـ Triglyceride بشكل أساسي وأيضا ينقل لكلسترول ولكن بنسبة قليلة", "tokens": [4587, 1211, 8315, 36145, 2423, 39184, 691, 23704, 43, 23758, 2423, 39184, 4372, 2295, 10305, 8280, 404, 81, 1370, 259, 44945, 4587, 1211, 5296, 39184, 1765, 328, 356, 1776, 482, 4724, 8592, 28820, 5551, 3794, 32277, 1829, 36725, 1829, 11242, 995, 7251, 1863, 4587, 1211, 5296, 28820, 14851, 2288, 12610, 35525, 19452, 44945, 35457, 3660, 12174, 20292, 37977], "avg_logprob": -0.17862818200709457, "compression_ratio": 1.2620689655172415, "no_speech_prob": 0.0, "words": [{"start": 1571.8, "end": 1572.2, "word": "قلنا", "probability": 0.7679036458333334}, {"start": 1572.2, "end": 1572.44, "word": " إن", "probability": 0.68408203125}, {"start": 1572.44, "end": 1572.7, "word": " الـ", "probability": 0.873046875}, {"start": 1572.7, "end": 1573.8, "word": " VLDL", "probability": 0.9169921875}, {"start": 1573.8, "end": 1574.3, "word": " هذا", "probability": 0.70703125}, {"start": 1574.3, "end": 1574.52, "word": " الـ", "probability": 0.943359375}, {"start": 1574.52, "end": 1574.64, "word": " Very", "probability": 0.46826171875}, {"start": 1574.64, "end": 1574.86, "word": " low", "probability": 0.3369140625}, {"start": 1574.86, "end": 1575.2, "word": " density", "probability": 0.81103515625}, {"start": 1575.2, "end": 1576.12, "word": " lipoprotein", "probability": 0.8765625}, {"start": 1576.12, "end": 1576.76, "word": " بنقل", "probability": 0.8792317708333334}, {"start": 1576.76, "end": 1576.98, "word": " لـ", "probability": 0.707275390625}, {"start": 1576.98, "end": 1577.92, "word": " Triglyceride", "probability": 0.801708984375}, {"start": 1577.92, "end": 1578.4, "word": " بشكل", "probability": 0.9886067708333334}, {"start": 1578.4, "end": 1579.12, "word": " أساسي", "probability": 0.9814453125}, {"start": 1579.12, "end": 1580.08, "word": " وأيضا", "probability": 0.8953857421875}, {"start": 1580.08, "end": 1580.58, "word": " ينقل", "probability": 0.92333984375}, {"start": 1580.58, "end": 1581.46, "word": " لكلسترول", "probability": 0.7841796875}, {"start": 1581.46, "end": 1582.12, "word": " ولكن", "probability": 0.89990234375}, {"start": 1582.12, "end": 1582.78, "word": " بنسبة", "probability": 0.92333984375}, {"start": 1582.78, "end": 1583.32, "word": " قليلة", "probability": 0.9832356770833334}], "temperature": 1.0}, {"id": 71, "seek": 160970, "start": 1584.24, "end": 1609.7, "text": "أما الـ HDL و الـ LDL هدول نواقل خاصة بالكلسترول الـ HDL-Lipoproteins are assayed كيف أنا ممكن يعني أقيس الكلسترول اللي بيحمله الـ HDL هذا الناقل الـ High Density Lipoprotein عن طريق أني أرسب النواقل الأخرى أرسب الـ LDL", "tokens": [10721, 15042, 2423, 39184, 12149, 43, 4032, 2423, 39184, 33936, 43, 8032, 3215, 12610, 8717, 14407, 4587, 1211, 16490, 33546, 3660, 20666, 28820, 14851, 2288, 12610, 2423, 39184, 12149, 43, 12, 43, 647, 404, 81, 1370, 1292, 366, 1256, 47315, 9122, 33911, 41850, 3714, 43020, 37495, 22653, 5551, 38436, 3794, 2423, 28820, 14851, 2288, 12610, 13672, 1829, 4724, 1829, 35571, 43761, 2423, 39184, 12149, 43, 23758, 28239, 995, 4587, 1211, 2423, 39184, 5229, 413, 6859, 27475, 404, 81, 1370, 259, 18871, 23032, 16572, 4587, 14739, 1829, 5551, 2288, 3794, 3555, 28239, 14407, 4587, 1211, 16247, 34740, 7578, 5551, 2288, 3794, 3555, 2423, 39184, 33936, 43], "avg_logprob": -0.14482605499479007, "compression_ratio": 1.691542288557214, "no_speech_prob": 0.0, "words": [{"start": 1584.24, "end": 1584.6, "word": "أما", 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"-Lipoproteins", "probability": 0.7898646763392857}, {"start": 1593.32, "end": 1593.84, "word": " are", "probability": 0.68896484375}, {"start": 1593.84, "end": 1594.64, "word": " assayed", "probability": 0.685302734375}, {"start": 1594.64, "end": 1595.18, "word": " كيف", "probability": 0.95751953125}, {"start": 1595.18, "end": 1595.48, "word": " أنا", "probability": 0.76025390625}, {"start": 1595.48, "end": 1595.98, "word": " ممكن", "probability": 0.98974609375}, {"start": 1595.98, "end": 1596.64, "word": " يعني", "probability": 0.846923828125}, {"start": 1596.64, "end": 1597.38, "word": " أقيس", "probability": 0.8186848958333334}, {"start": 1597.38, "end": 1598.74, "word": " الكلسترول", "probability": 0.8875}, {"start": 1598.74, "end": 1599.12, "word": " اللي", "probability": 0.92431640625}, {"start": 1599.12, "end": 1599.84, "word": " بيحمله", "probability": 0.982421875}, {"start": 1599.84, "end": 1600.32, "word": " الـ", "probability": 0.9755859375}, {"start": 1600.32, "end": 1601.08, "word": " HDL", "probability": 0.87646484375}, {"start": 1601.08, "end": 1601.5, "word": " هذا", "probability": 0.791015625}, {"start": 1601.5, "end": 1602.2, "word": " الناقل", "probability": 0.9327392578125}, {"start": 1602.2, "end": 1602.46, "word": " الـ", "probability": 0.93994140625}, {"start": 1602.46, "end": 1602.6, "word": " High", "probability": 0.478515625}, {"start": 1602.6, "end": 1603.14, "word": " Density", "probability": 0.72119140625}, {"start": 1603.14, "end": 1604.16, "word": " Lipoprotein", "probability": 0.92919921875}, {"start": 1604.16, "end": 1604.96, "word": " عن", "probability": 0.9326171875}, {"start": 1604.96, "end": 1605.6, "word": " طريق", "probability": 0.99755859375}, {"start": 1605.6, "end": 1606.14, "word": " أني", "probability": 0.70849609375}, {"start": 1606.14, "end": 1606.84, "word": " أرسب", "probability": 0.721923828125}, {"start": 1606.84, "end": 1607.62, "word": " النواقل", "probability": 0.9725341796875}, {"start": 1607.62, "end": 1608.26, "word": " الأخرى", "probability": 0.9920247395833334}, {"start": 1608.26, "end": 1608.98, "word": " أرسب", "probability": 0.900634765625}, {"start": 1608.98, "end": 1609.2, "word": " الـ", "probability": 0.9423828125}, {"start": 1609.2, "end": 1609.7, "word": " LDL", "probability": 0.95458984375}], "temperature": 1.0}, {"id": 72, "seek": 161746, "start": 1610.18, "end": 1617.46, "text": "والـ VLDL في القاع ومين بيضل الـ supernatant في الـ supernatant بيضل الـ HDL", "tokens": [2407, 6027, 39184, 691, 23704, 43, 8978, 25062, 45761, 4032, 2304, 9957, 4724, 1829, 11242, 1211, 2423, 39184, 1687, 12241, 394, 8978, 2423, 39184, 1687, 12241, 394, 4724, 1829, 11242, 1211, 2423, 39184, 12149, 43], "avg_logprob": -0.2341579852832688, "compression_ratio": 1.4285714285714286, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1610.18, "end": 1610.68, "word": "والـ", "probability": 0.6613362630208334}, {"start": 1610.68, "end": 1611.42, "word": " VLDL", "probability": 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1624.26, "end": 1624.64, "word": " مادة", "probability": 0.9140625}, {"start": 1624.64, "end": 1625.02, "word": " بتكون", "probability": 0.7008056640625}, {"start": 1625.02, "end": 1625.64, "word": " موجودة", "probability": 0.96484375}, {"start": 1625.64, "end": 1625.9, "word": " بالـ", "probability": 0.90625}, {"start": 1625.9, "end": 1626.48, "word": " Reagent", "probability": 0.7151692708333334}, {"start": 1626.48, "end": 1626.92, "word": " تبع", "probability": 0.9290364583333334}, {"start": 1626.92, "end": 1627.38, "word": " الـ", "probability": 0.86279296875}, {"start": 1627.38, "end": 1627.62, "word": " kit", "probability": 0.359130859375}, {"start": 1627.62, "end": 1627.94, "word": " تبع", "probability": 0.9161783854166666}, {"start": 1627.94, "end": 1628.38, "word": " فحص", "probability": 0.9793294270833334}, {"start": 1628.38, "end": 1628.64, "word": " الـ", "probability": 0.974365234375}, {"start": 1628.64, "end": 1629.28, "word": " HDL", "probability": 0.8388671875}, {"start": 1629.28, "end": 1630.0, "word": " لما", "probability": 0.849365234375}, {"start": 1630.0, "end": 1630.42, "word": " بضيف", "probability": 0.8849283854166666}, {"start": 1630.42, "end": 1630.66, "word": " الـ", "probability": 0.929443359375}, {"start": 1630.66, "end": 1631.24, "word": " Reagent", "probability": 0.8972981770833334}, {"start": 1631.24, "end": 1631.54, "word": " على", "probability": 0.796875}, {"start": 1631.54, "end": 1632.18, "word": " السيرم", "probability": 0.7189127604166666}, {"start": 1632.18, "end": 1632.68, "word": " الـ", "probability": 0.8974609375}, {"start": 1632.68, "end": 1633.18, "word": " Reagent", "probability": 0.9632161458333334}, {"start": 1633.18, "end": 1633.48, "word": " فيه", "probability": 0.906982421875}, {"start": 1633.48, "end": 1633.9, "word": " مادة", "probability": 0.95947265625}, {"start": 1633.9, "end": 1634.18, "word": " الـ", "probability": 0.92919921875}, {"start": 1634.18, "end": 1634.84, "word": " Polyethylene", "probability": 0.8732096354166666}, {"start": 1634.84, "end": 1635.54, "word": " Glycol", "probability": 0.9728190104166666}, {"start": 1635.54, "end": 1635.96, "word": " اللي", "probability": 0.849609375}, {"start": 1635.96, "end": 1636.64, "word": " بترسب", "probability": 0.835205078125}, {"start": 1636.64, "end": 1636.9, "word": " الـ", "probability": 0.939453125}, {"start": 1636.9, "end": 1637.54, "word": " LDL", "probability": 0.92236328125}, {"start": 1637.54, "end": 1637.88, "word": " و", "probability": 0.7685546875}, {"start": 1637.88, "end": 1638.08, "word": " الـ", "probability": 0.6600341796875}, {"start": 1638.08, "end": 1639.06, "word": " VLDL", "probability": 0.953125}, {"start": 1639.06, "end": 1639.28, "word": " و", "probability": 0.9443359375}, {"start": 1639.28, "end": 1640.42, "word": " الكايلومايكرون", "probability": 0.6901332310267857}], "temperature": 1.0}, {"id": 74, "seek": 166477, "start": 1640.87, "end": 1664.77, "text": "فقط هيضلوا في الـ supernatant الـ HDL بناخده و بنحسب تركيز الكوليسترول اللي بيكون جوات الـ HDL HDL is left in the supernatant solution for cholesterol quantitation عشان نقيس تركيز الكوليسترول اللي جواته وهذا فحص الـ HDLC", "tokens": [5172, 47432, 39896, 11242, 1211, 14407, 8978, 2423, 39184, 1687, 12241, 394, 2423, 39184, 12149, 43, 44945, 47283, 3215, 3224, 4032, 44945, 5016, 35457, 6055, 31747, 1829, 11622, 33251, 12610, 1829, 14851, 2288, 12610, 13672, 1829, 4724, 1829, 30544, 10874, 2407, 9307, 2423, 39184, 12149, 43, 12149, 43, 307, 1411, 294, 264, 1687, 12241, 394, 3827, 337, 24716, 4426, 4614, 6225, 8592, 7649, 8717, 38436, 3794, 6055, 31747, 1829, 11622, 33251, 12610, 1829, 14851, 2288, 12610, 13672, 1829, 10874, 2407, 9307, 3224, 37037, 15730, 6156, 5016, 9381, 2423, 39184, 12149, 14766], "avg_logprob": -0.14809782462923424, "compression_ratio": 1.6787564766839378, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 1640.87, "end": 1641.43, "word": "فقط", "probability": 0.94873046875}, {"start": 1641.43, 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{"start": 1649.11, "end": 1649.65, "word": " بيكون", "probability": 0.9357096354166666}, {"start": 1649.65, "end": 1650.55, "word": " جوات", "probability": 0.6564127604166666}, {"start": 1650.55, "end": 1651.09, "word": " الـ", "probability": 0.974365234375}, {"start": 1651.09, "end": 1651.77, "word": " HDL", "probability": 0.886474609375}, {"start": 1651.77, "end": 1652.91, "word": " HDL", "probability": 0.94091796875}, {"start": 1652.91, "end": 1653.23, "word": " is", "probability": 0.81884765625}, {"start": 1653.23, "end": 1653.61, "word": " left", "probability": 0.9375}, {"start": 1653.61, "end": 1654.09, "word": " in", "probability": 0.96142578125}, {"start": 1654.09, "end": 1654.29, "word": " the", "probability": 0.91162109375}, {"start": 1654.29, "end": 1654.91, "word": " supernatant", "probability": 0.9366861979166666}, {"start": 1654.91, "end": 1655.49, "word": " solution", "probability": 0.951171875}, {"start": 1655.49, "end": 1656.03, "word": " for", "probability": 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"word": " HDLC", "probability": 0.7509765625}], "temperature": 1.0}, {"id": 75, "seek": 168264, "start": 1665.34, "end": 1682.64, "text": "HDL كوليسترول يعني حساب الكوليسترول اللي موجود ومحمول على اللايبو بروتين HDL low density lipoprotein الـ LDL الناقل الآخر", "tokens": [22859, 43, 9122, 12610, 1829, 14851, 2288, 12610, 37495, 22653, 11331, 3794, 16758, 33251, 12610, 1829, 14851, 2288, 12610, 13672, 1829, 3714, 29245, 23328, 4032, 2304, 35571, 12610, 15844, 13672, 47302, 3555, 2407, 4724, 32887, 2655, 9957, 12149, 43, 2295, 10305, 8280, 404, 81, 1370, 259, 2423, 39184, 33936, 43, 28239, 995, 4587, 1211, 6024, 95, 34740], "avg_logprob": -0.23316271937098995, "compression_ratio": 1.3472222222222223, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 1665.34, "end": 1666.2, "word": "HDL", "probability": 0.709228515625}, {"start": 1666.2, "end": 1667.16, "word": " كوليسترول", "probability": 0.8475341796875}, {"start": 1667.16, "end": 1667.48, "word": " يعني", "probability": 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lipoprotein", "probability": 0.79833984375}, {"start": 1679.72, "end": 1680.18, "word": " الـ", "probability": 0.5067138671875}, {"start": 1680.18, "end": 1680.98, "word": " LDL", "probability": 0.875732421875}, {"start": 1680.98, "end": 1681.94, "word": " الناقل", "probability": 0.8798828125}, {"start": 1681.94, "end": 1682.64, "word": " الآخر", "probability": 0.9365234375}], "temperature": 1.0}, {"id": 76, "seek": 169956, "start": 1684.06, "end": 1699.56, "text": "هلجيت يا جماعة الـ LDL برضه إله كيت خاص فيه عشان من خلال هذا الـ kit انقيس تركيز الكوليسترول اللي موجود في هذا الناقل في الـ LDL لكن جاله فيه طريقة سهلة", "tokens": [3224, 1211, 7435, 36081, 35186, 10874, 15042, 27884, 2423, 39184, 33936, 43, 4724, 43042, 3224, 11933, 43761, 9122, 36081, 16490, 33546, 8978, 3224, 6225, 8592, 7649, 9154, 16490, 1211, 6027, 23758, 2423, 39184, 8260, 16472, 38436, 3794, 6055, 31747, 1829, 11622, 33251, 12610, 1829, 14851, 2288, 12610, 13672, 1829, 3714, 29245, 23328, 8978, 23758, 28239, 995, 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"end": 1688.94, "word": " فيه", "probability": 0.98828125}, {"start": 1688.94, "end": 1689.56, "word": " عشان", "probability": 0.9786783854166666}, {"start": 1689.56, "end": 1689.92, "word": " من", "probability": 0.99560546875}, {"start": 1689.92, "end": 1690.32, "word": " خلال", "probability": 0.994140625}, {"start": 1690.32, "end": 1690.58, "word": " هذا", "probability": 0.841796875}, {"start": 1690.58, "end": 1690.8, "word": " الـ", "probability": 0.872802734375}, {"start": 1690.8, "end": 1691.04, "word": " kit", "probability": 0.5361328125}, {"start": 1691.04, "end": 1691.88, "word": " انقيس", "probability": 0.6520182291666666}, {"start": 1691.88, "end": 1692.6, "word": " تركيز", "probability": 0.9835205078125}, {"start": 1692.6, "end": 1693.6, "word": " الكوليسترول", "probability": 0.9048665364583334}, {"start": 1693.6, "end": 1694.04, "word": " اللي", "probability": 0.872314453125}, {"start": 1694.04, "end": 1694.64, "word": " موجود", "probability": 0.9855143229166666}, {"start": 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معادلة اسمها Fredwald equation أطبقها وبالتالي من خلالها بقدر أعرف تركيز الكوليسترول اللي موجود و اللي محمول داخل الـ LDL الـ LDL كوليسترول، تركيز الكوليسترول اللي محمول بواسطة الـ LDL إيش بدو يساوي؟", "tokens": [2304, 43020, 9154, 16490, 1211, 6027, 20449, 18513, 37977, 24525, 2304, 11296, 10112, 33262, 5367, 5551, 9566, 3555, 4587, 11296, 46599, 6027, 2655, 6027, 1829, 9154, 16490, 1211, 6027, 11296, 4724, 28543, 2288, 5551, 3615, 28480, 6055, 31747, 1829, 11622, 33251, 12610, 1829, 14851, 2288, 12610, 13672, 1829, 3714, 29245, 23328, 4032, 13672, 1829, 3714, 35571, 12610, 11778, 47283, 1211, 2423, 39184, 33936, 43, 2423, 39184, 33936, 43, 9122, 12610, 1829, 14851, 2288, 12610, 12399, 6055, 31747, 1829, 11622, 33251, 12610, 1829, 14851, 2288, 12610, 13672, 1829, 3714, 35571, 12610, 4724, 14407, 3794, 9566, 3660, 2423, 39184, 33936, 43, 11933, 1829, 8592, 47525, 2407, 7251, 3794, 995, 45865, 22807], "avg_logprob": -0.12294033738699826, "compression_ratio": 1.8958333333333333, 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1707.65, "end": 1708.23, "word": " بقدر", "probability": 0.9729817708333334}, {"start": 1708.23, "end": 1708.75, "word": " أعرف", "probability": 0.91552734375}, {"start": 1708.75, "end": 1709.41, "word": " تركيز", "probability": 0.986572265625}, {"start": 1709.41, "end": 1710.29, "word": " الكوليسترول", "probability": 0.941650390625}, {"start": 1710.29, "end": 1710.69, "word": " اللي", "probability": 0.796875}, {"start": 1710.69, "end": 1711.25, "word": " موجود", "probability": 0.9856770833333334}, {"start": 1711.25, "end": 1711.85, "word": " و", "probability": 0.7705078125}, {"start": 1711.85, "end": 1712.07, "word": " اللي", "probability": 0.59619140625}, {"start": 1712.07, "end": 1712.57, "word": " محمول", "probability": 0.9850260416666666}, {"start": 1712.57, "end": 1713.35, "word": " داخل", "probability": 0.95166015625}, {"start": 1713.35, "end": 1713.77, "word": " الـ", "probability": 0.8671875}, {"start": 1713.77, "end": 1714.45, "word": " LDL", "probability": 0.8740234375}, {"start": 1714.45, "end": 1715.81, "word": " الـ", "probability": 0.708984375}, {"start": 1715.81, "end": 1716.41, "word": " LDL", "probability": 0.880615234375}, {"start": 1716.41, "end": 1717.49, "word": " كوليسترول،", "probability": 0.8373674665178571}, {"start": 1717.49, "end": 1717.93, "word": " تركيز", "probability": 0.977783203125}, {"start": 1717.93, "end": 1718.71, "word": " الكوليسترول", "probability": 0.9703776041666666}, {"start": 1718.71, "end": 1719.01, "word": " اللي", "probability": 0.964599609375}, {"start": 1719.01, "end": 1719.57, "word": " محمول", "probability": 0.9851888020833334}, {"start": 1719.57, "end": 1721.09, "word": " بواسطة", "probability": 0.9791015625}, {"start": 1721.09, "end": 1721.61, "word": " الـ", "probability": 0.873046875}, {"start": 1721.61, "end": 1722.41, "word": " LDL", "probability": 0.8896484375}, {"start": 1722.41, "end": 1722.91, "word": " إيش", "probability": 0.8090006510416666}, {"start": 1722.91, "end": 1723.23, "word": " بدو", "probability": 0.4791259765625}, {"start": 1723.23, "end": 1723.97, "word": " يساوي؟", "probability": 0.9130859375}], "temperature": 1.0}, {"id": 78, "seek": 175093, "start": 1724.49, "end": 1750.93, "text": "بدو يساوي الـ Total Cholesterol أي تركيز الكوليسترول الكامل اللي حسبناه في البلازمة ناقص الـ HDL-cholesterol يعني ناقص الكوليسترول اللي موجود ومحمول داخل الـ HDL ما هذا برضه احنا جبناه وحسبناه بطريقة الـ kit و Total Cholesterol حسبناه", "tokens": [44510, 2407, 7251, 3794, 995, 45865, 2423, 39184, 23170, 761, 401, 21947, 36632, 6055, 31747, 1829, 11622, 33251, 12610, 1829, 14851, 2288, 12610, 33251, 10943, 1211, 13672, 1829, 11331, 35457, 8315, 3224, 8978, 29739, 1211, 31377, 46007, 8717, 995, 4587, 9381, 2423, 39184, 12149, 43, 12, 339, 401, 21947, 37495, 22653, 8717, 995, 4587, 9381, 33251, 12610, 1829, 14851, 2288, 12610, 13672, 1829, 3714, 29245, 23328, 4032, 2304, 35571, 12610, 11778, 47283, 1211, 2423, 39184, 12149, 43, 19446, 23758, 4724, 43042, 3224, 1975, 5016, 8315, 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"end": 1731.05, "word": " الكامل", "probability": 0.8605143229166666}, {"start": 1731.05, "end": 1731.43, "word": " اللي", "probability": 0.7548828125}, {"start": 1731.43, "end": 1732.13, "word": " حسبناه", "probability": 0.977783203125}, {"start": 1732.13, "end": 1732.25, "word": " في", "probability": 0.85107421875}, {"start": 1732.25, "end": 1733.43, "word": " البلازمة", "probability": 0.875244140625}, {"start": 1733.43, "end": 1734.83, "word": " ناقص", "probability": 0.9716796875}, {"start": 1734.83, "end": 1735.43, "word": " الـ", "probability": 0.986572265625}, {"start": 1735.43, "end": 1736.13, "word": " HDL", "probability": 0.785888671875}, {"start": 1736.13, "end": 1736.85, "word": "-cholesterol", "probability": 0.60418701171875}, {"start": 1736.85, "end": 1737.47, "word": " يعني", "probability": 0.902587890625}, {"start": 1737.47, "end": 1738.15, "word": " ناقص", "probability": 0.993408203125}, {"start": 1738.15, "end": 1739.65, "word": " الكوليسترول", "probability": 0.9409993489583334}, {"start": 1739.65, "end": 1740.81, "word": " اللي", "probability": 0.952880859375}, {"start": 1740.81, "end": 1741.81, "word": " موجود", "probability": 0.9827473958333334}, {"start": 1741.81, "end": 1742.73, "word": " ومحمول", "probability": 0.9752197265625}, {"start": 1742.73, "end": 1743.41, "word": " داخل", "probability": 0.9576822916666666}, {"start": 1743.41, "end": 1743.61, "word": " الـ", "probability": 0.982421875}, {"start": 1743.61, "end": 1744.21, "word": " HDL", "probability": 0.7474365234375}, {"start": 1744.21, "end": 1744.49, "word": " ما", "probability": 0.572265625}, {"start": 1744.49, "end": 1744.67, "word": " هذا", "probability": 0.4248046875}, {"start": 1744.67, "end": 1744.99, "word": " برضه", "probability": 0.9479166666666666}, {"start": 1744.99, "end": 1745.31, "word": " احنا", "probability": 0.8538411458333334}, {"start": 1745.31, "end": 1746.13, "word": " جبناه", "probability": 0.9730224609375}, {"start": 1746.13, "end": 1747.19, "word": " وحسبناه", "probability": 0.8736328125}, {"start": 1747.19, "end": 1747.85, "word": " بطريقة", "probability": 0.984130859375}, {"start": 1747.85, "end": 1748.11, "word": " الـ", "probability": 0.905517578125}, {"start": 1748.11, "end": 1748.37, "word": " kit", "probability": 0.2486572265625}, {"start": 1748.37, "end": 1748.93, "word": " و", "probability": 0.6435546875}, {"start": 1748.93, "end": 1749.29, "word": " Total", "probability": 0.4296875}, {"start": 1749.29, "end": 1750.05, "word": " Cholesterol", "probability": 0.87451171875}, {"start": 1750.05, "end": 1750.93, "word": " حسبناه", "probability": 0.9910888671875}], "temperature": 1.0}, {"id": 79, "seek": 176703, "start": 1751.71, "end": 1767.03, "text": "حكيته لكم الطريقة الـ procedure تبعته ناقص لـ triglyceride تركيز لـ triglyceride على 2.2 بتجسمي نتيجة لـ triglyceride على 2.2", "tokens": [5016, 4117, 36081, 3224, 5296, 24793, 41950, 16572, 28671, 2423, 39184, 10747, 6055, 3555, 34268, 3224, 8717, 995, 4587, 9381, 5296, 39184, 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"end": 1758.47, "word": " triglyceride", "probability": 0.78204345703125}, {"start": 1758.47, "end": 1759.13, "word": " تركيز", "probability": 0.9381103515625}, {"start": 1759.13, "end": 1759.43, "word": " لـ", "probability": 0.9365234375}, {"start": 1759.43, "end": 1760.41, "word": " triglyceride", "probability": 0.906494140625}, {"start": 1760.41, "end": 1760.95, "word": " على", "probability": 0.84765625}, {"start": 1760.95, "end": 1761.65, "word": " 2", "probability": 0.93896484375}, {"start": 1761.65, "end": 1762.37, "word": ".2", "probability": 0.9912109375}, {"start": 1762.37, "end": 1763.19, "word": " بتجسمي", "probability": 0.8582763671875}, {"start": 1763.19, "end": 1763.65, "word": " نتيجة", "probability": 0.9921875}, {"start": 1763.65, "end": 1763.93, "word": " لـ", "probability": 0.770263671875}, {"start": 1763.93, "end": 1764.85, "word": " triglyceride", "probability": 0.93798828125}, {"start": 1764.85, "end": 1765.25, "word": " على", "probability": 0.900390625}, {"start": 1765.25, "end": 1765.95, "word": " 2", "probability": 0.99267578125}, {"start": 1765.95, "end": 1767.03, "word": ".2", "probability": 0.998046875}], "temperature": 1.0}, {"id": 80, "seek": 178170, "start": 1767.3, "end": 1781.7, "text": "والنتيجة اللى تطلع هو تركيز الكوليسترول اللى موجود داخل الـ LDL و الوحدة بتكون بالملي مول per لتر", "tokens": [2407, 6027, 29399, 1829, 7435, 3660, 13672, 7578, 6055, 9566, 1211, 3615, 31439, 6055, 31747, 1829, 11622, 33251, 12610, 1829, 14851, 2288, 12610, 13672, 7578, 3714, 29245, 23328, 11778, 47283, 1211, 2423, 39184, 33936, 43, 4032, 2423, 2407, 24401, 3660, 39894, 30544, 20666, 2304, 20292, 3714, 12610, 680, 5296, 2655, 2288], "avg_logprob": -0.24218750200592554, "compression_ratio": 1.4132231404958677, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 1767.3, "end": 1768.62, "word": "والنتيجة", "probability": 0.8737386067708334}, {"start": 1768.62, "end": 1768.96, "word": " اللى", "probability": 0.719970703125}, {"start": 1768.96, 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1876.06, "word": " بجسم", "probability": 0.8180338541666666}, {"start": 1876.06, "end": 1876.26, "word": " ل", "probability": 0.943359375}, {"start": 1876.26, "end": 1877.22, "word": " Triglyceride", "probability": 0.88017578125}, {"start": 1877.22, "end": 1877.6, "word": " بدل", "probability": 0.976318359375}, {"start": 1877.6, "end": 1877.68, "word": " ما", "probability": 0.9521484375}, {"start": 1877.68, "end": 1877.84, "word": " هي", "probability": 0.931640625}, {"start": 1877.84, "end": 1877.98, "word": " على", "probability": 0.424072265625}, {"start": 1877.98, "end": 1878.2, "word": " 2", "probability": 0.98974609375}, {"start": 1878.2, "end": 1878.8, "word": ".2", "probability": 0.998291015625}, {"start": 1878.8, "end": 1879.6, "word": " بجسمها", "probability": 0.9505615234375}, {"start": 1879.6, "end": 1879.94, "word": " على", "probability": 0.93603515625}, {"start": 1879.94, "end": 1880.54, "word": " 5", "probability": 0.8623046875}], "temperature": 1.0}, {"id": 86, "seek": 189756, "start": 1881.36, "end": 1897.56, "text": "وقلنا هذه معادلة لو جبت تركيز لـ Triglyceride وجسمته على خمسة هيطلع لتركيز الكوليسترول اللي محمول جوات الـ VLDL تمام؟ إذن", "tokens": [2407, 4587, 1211, 8315, 29538, 20449, 18513, 37977, 45164, 10874, 3555, 2655, 6055, 31747, 1829, 11622, 5296, 39184, 1765, 328, 356, 1776, 482, 4032, 7435, 38251, 47395, 15844, 16490, 2304, 3794, 3660, 8032, 1829, 9566, 1211, 3615, 5296, 2655, 31747, 1829, 11622, 33251, 12610, 1829, 14851, 2288, 12610, 13672, 1829, 3714, 35571, 12610, 10874, 2407, 9307, 2423, 39184, 691, 23704, 43, 46811, 10943, 22807, 11933, 8848, 1863], "avg_logprob": -0.20530790835618973, "compression_ratio": 1.3205128205128205, "no_speech_prob": 2.980232238769531e-07, "words": [{"start": 1881.36, "end": 1881.88, "word": "وقلنا", "probability": 0.72491455078125}, {"start": 1881.88, "end": 1882.28, "word": " هذه", "probability": 0.69921875}, {"start": 1882.28, "end": 1882.94, "word": " معادلة", "probability": 0.9664713541666666}, {"start": 1882.94, "end": 1883.36, "word": " لو", "probability": 0.77197265625}, {"start": 1883.36, "end": 1883.8, "word": " جبت", "probability": 0.962890625}, {"start": 1883.8, "end": 1884.56, "word": " تركيز", "probability": 0.9891357421875}, {"start": 1884.56, "end": 1884.92, "word": " لـ", "probability": 0.79833984375}, {"start": 1884.92, "end": 1885.94, "word": " Triglyceride", "probability": 0.806494140625}, {"start": 1885.94, "end": 1886.82, "word": " وجسمته", "probability": 0.7918701171875}, {"start": 1886.82, "end": 1887.02, "word": " على", "probability": 0.92529296875}, {"start": 1887.02, "end": 1887.8, "word": " خمسة", "probability": 0.8785400390625}, {"start": 1887.8, "end": 1889.0, "word": " هيطلع", "probability": 0.775341796875}, {"start": 1889.0, "end": 1890.04, "word": " لتركيز", "probability": 0.95244140625}, {"start": 1890.04, "end": 1891.5, "word": " الكوليسترول", "probability": 0.8876953125}, {"start": 1891.5, "end": 1892.08, "word": " اللي", "probability": 0.88427734375}, {"start": 1892.08, "end": 1892.7, "word": " محمول", "probability": 0.984375}, {"start": 1892.7, "end": 1893.34, "word": " جوات", "probability": 0.6156005859375}, {"start": 1893.34, "end": 1893.6, "word": " الـ", "probability": 0.837646484375}, {"start": 1893.6, "end": 1894.84, "word": " VLDL", "probability": 0.9085286458333334}, {"start": 1894.84, "end": 1896.22, "word": " تمام؟", "probability": 0.8255208333333334}, {"start": 1896.22, "end": 1897.56, "word": " إذن", "probability": 0.673828125}], "temperature": 1.0}, {"id": 87, "seek": 191218, "start": 1898.18, "end": 1912.18, "text": "Where all concentrations are given in millimoles per liter المعادلة الزرجة لو كل الوحدات كانت يعني لما أجسمها 2.2 لـ triglyceride الوحدة بتطلع بالmillimoles per liter", "tokens": [14436, 439, 33512, 366, 2212, 294, 1728, 332, 7456, 680, 2733, 9673, 3615, 18513, 37977, 6024, 110, 47341, 3660, 45164, 28242, 2423, 2407, 24401, 9307, 25961, 2655, 37495, 22653, 5296, 15042, 5551, 7435, 38251, 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"probability": 0.8017578125}, {"start": 1902.18, "end": 1902.82, "word": " المعادلة", "probability": 0.8875732421875}, {"start": 1902.82, "end": 1903.42, "word": " الزرجة", "probability": 0.72314453125}, {"start": 1903.42, "end": 1903.84, "word": " لو", "probability": 0.830078125}, {"start": 1903.84, "end": 1904.36, "word": " كل", "probability": 0.83056640625}, {"start": 1904.36, "end": 1905.72, "word": " الوحدات", "probability": 0.961181640625}, {"start": 1905.72, "end": 1906.26, "word": " كانت", "probability": 0.957275390625}, {"start": 1906.26, "end": 1906.7, "word": " يعني", "probability": 0.55950927734375}, {"start": 1906.7, "end": 1906.92, "word": " لما", "probability": 0.908447265625}, {"start": 1906.92, "end": 1907.42, "word": " أجسمها", "probability": 0.70745849609375}, {"start": 1907.42, "end": 1907.62, "word": " 2", "probability": 0.71142578125}, {"start": 1907.62, "end": 1908.3, "word": ".2", "probability": 0.96875}, {"start": 1908.3, "end": 1909.12, "word": " لـ", "probability": 0.65869140625}, {"start": 1909.12, "end": 1910.02, "word": " triglyceride", "probability": 0.7762451171875}, {"start": 1910.02, "end": 1910.54, "word": " الوحدة", "probability": 0.9541015625}, {"start": 1910.54, "end": 1911.02, "word": " بتطلع", "probability": 0.88330078125}, {"start": 1911.02, "end": 1911.6, "word": " بالmillimoles", "probability": 0.81243896484375}, {"start": 1911.6, "end": 1911.84, "word": " per", "probability": 0.9228515625}, {"start": 1911.84, "end": 1912.18, "word": " liter", "probability": 0.83837890625}], "temperature": 1.0}, {"id": 88, "seek": 193885, "start": 1913.25, "end": 1938.85, "text": "إذا كتبت تركيز الكوليسترول بالملي جرام بار دي سيلتر لو أنا بدي المعادلة بالملي جرام بار دي سيلتر و النتيجة تركيز الكوليسترول بالملي جرام بار دي سيلتر بديك تجسم لـ Triglyceride على خمسة بدل من 2.2 The Quotient Triglyceride على خمسة لو جسمت لـ Triglyceride على خمسة", "tokens": [28814, 15730, 9122, 2655, 3555, 2655, 6055, 2288, 4117, 1829, 11622, 33251, 12610, 1829, 14851, 2288, 12610, 20666, 2304, 20292, 10874, 2288, 10943, 4724, 9640, 11778, 1829, 8608, 26895, 2655, 2288, 45164, 41850, 4724, 16254, 9673, 3615, 18513, 37977, 20666, 2304, 20292, 10874, 2288, 10943, 4724, 9640, 11778, 1829, 8608, 26895, 2655, 2288, 4032, 28239, 31371, 7435, 3660, 6055, 31747, 1829, 11622, 33251, 12610, 1829, 14851, 2288, 12610, 20666, 2304, 20292, 10874, 2288, 10943, 4724, 9640, 11778, 1829, 8608, 26895, 2655, 2288, 4724, 16254, 4117, 6055, 7435, 38251, 5296, 39184, 1765, 328, 356, 1776, 482, 15844, 16490, 2304, 3794, 3660, 47525, 1211, 9154, 568, 13, 17, 440, 2326, 310, 1196, 1765, 328, 356, 1776, 482, 15844, 16490, 2304, 3794, 3660, 45164, 10874, 38251, 2655, 5296, 39184, 1765, 328, 356, 1776, 482, 15844, 16490, 2304, 3794, 3660], "avg_logprob": -0.23791057785062025, "compression_ratio": 2.299465240641711, "no_speech_prob": 0.0, "words": [{"start": 1913.25, "end": 1913.59, "word": "إذا", "probability": 0.556640625}, {"start": 1913.59, "end": 1914.61, "word": " كتبت", "probability": 0.58575439453125}, {"start": 1914.61, "end": 1915.27, "word": " تركيز", "probability": 0.6334228515625}, {"start": 1915.27, "end": 1915.27, "word": " الكوليسترول", "probability": 0.91943359375}, {"start": 1915.27, "end": 1917.37, "word": " بالملي", "probability": 0.6102701822916666}, {"start": 1917.37, "end": 1917.75, "word": " جرام", "probability": 0.87841796875}, {"start": 1917.75, "end": 1918.05, "word": " بار", "probability": 0.2838134765625}, {"start": 1918.05, "end": 1918.25, "word": " دي", "probability": 0.972900390625}, {"start": 1918.25, "end": 1918.73, "word": " سيلتر", "probability": 0.66656494140625}, {"start": 1918.73, "end": 1918.95, "word": " لو", "probability": 0.129150390625}, {"start": 1918.95, "end": 1919.23, "word": " أنا", "probability": 0.57666015625}, {"start": 1919.23, "end": 1919.59, "word": " بدي", "probability": 0.6788330078125}, {"start": 1919.59, "end": 1920.41, "word": " المعادلة", "probability": 0.9853515625}, {"start": 1920.41, "end": 1921.01, "word": " بالملي", "probability": 0.91357421875}, {"start": 1921.01, "end": 1921.41, "word": " جرام", "probability": 0.9791666666666666}, {"start": 1921.41, "end": 1921.65, "word": " بار", "probability": 0.90185546875}, {"start": 1921.65, "end": 1921.85, "word": " دي", "probability": 0.992919921875}, {"start": 1921.85, "end": 1922.23, "word": " سيلتر", "probability": 0.9779052734375}, {"start": 1922.23, "end": 1922.47, "word": " و", "probability": 0.6025390625}, {"start": 1922.47, "end": 1923.21, "word": " النتيجة", "probability": 0.8753662109375}, {"start": 1923.21, "end": 1923.69, "word": " تركيز", "probability": 0.904541015625}, {"start": 1923.69, "end": 1924.33, "word": " الكوليسترول", "probability": 0.9689127604166666}, {"start": 1924.33, "end": 1925.25, "word": " بالملي", "probability": 0.9558919270833334}, {"start": 1925.25, "end": 1925.53, "word": " جرام", "probability": 0.9755859375}, {"start": 1925.53, "end": 1925.71, "word": " بار", "probability": 0.97412109375}, {"start": 1925.71, "end": 1925.89, "word": " دي", "probability": 0.98974609375}, {"start": 1925.89, "end": 1926.41, "word": " سيلتر", "probability": 0.98779296875}, {"start": 1926.41, "end": 1927.17, "word": " بديك", "probability": 0.6175944010416666}, {"start": 1927.17, "end": 1927.67, "word": " تجسم", "probability": 0.95263671875}, {"start": 1927.67, "end": 1928.03, "word": " لـ", "probability": 0.785400390625}, {"start": 1928.03, "end": 1928.95, "word": " Triglyceride", "probability": 0.8314208984375}, {"start": 1928.95, "end": 1929.39, "word": " على", "probability": 0.7392578125}, {"start": 1929.39, "end": 1930.23, "word": " خمسة", "probability": 0.8709716796875}, {"start": 1930.23, "end": 1930.59, "word": " بدل", "probability": 0.967041015625}, {"start": 1930.59, "end": 1930.79, "word": " من", "probability": 0.986328125}, {"start": 1930.79, "end": 1931.13, "word": " 2", "probability": 0.720703125}, {"start": 1931.13, "end": 1931.99, "word": ".2", "probability": 0.98486328125}, {"start": 1931.99, "end": 1933.23, "word": " The", "probability": 0.10284423828125}, {"start": 1933.23, "end": 1934.09, "word": " Quotient", "probability": 0.56982421875}, {"start": 1934.09, "end": 1935.73, "word": " Triglyceride", "probability": 0.941015625}, {"start": 1935.73, "end": 1935.91, "word": " على", "probability": 0.87451171875}, {"start": 1935.91, "end": 1936.47, "word": " خمسة", "probability": 0.9892578125}, {"start": 1936.47, "end": 1936.69, "word": " لو", "probability": 0.7646484375}, {"start": 1936.69, "end": 1937.19, "word": " جسمت", "probability": 0.9736328125}, {"start": 1937.19, "end": 1937.39, "word": " لـ", "probability": 0.858642578125}, {"start": 1937.39, "end": 1938.15, "word": " Triglyceride", "probability": 0.93955078125}, {"start": 1938.15, "end": 1938.31, "word": " على", "probability": 0.83984375}, {"start": 1938.31, "end": 1938.85, "word": " خمسة", "probability": 0.9891357421875}], "temperature": 1.0}, {"id": 89, "seek": 194975, "start": 1939.81, "end": 1949.75, "text": "is used and estimate هيك أنا بقدر اعرف تركيز الكلسترول اللي محمول بالـ VLDL", "tokens": [271, 1143, 293, 12539, 39896, 4117, 41850, 4724, 28543, 2288, 1975, 3615, 28480, 6055, 31747, 1829, 11622, 2423, 28820, 14851, 2288, 12610, 13672, 1829, 3714, 35571, 12610, 20666, 39184, 691, 23704, 43], "avg_logprob": -0.25757575757575757, "compression_ratio": 1.0943396226415094, "no_speech_prob": 0.0, "words": [{"start": 1939.81, "end": 1940.13, "word": "is", "probability": 0.051544189453125}, {"start": 1940.13, "end": 1940.57, "word": " used", "probability": 0.931640625}, {"start": 1940.57, "end": 1941.09, "word": " and", "probability": 0.51220703125}, {"start": 1941.09, "end": 1942.01, "word": " estimate", "probability": 0.806640625}, {"start": 1942.01, "end": 1942.67, "word": " هيك", "probability": 0.859619140625}, {"start": 1942.67, "end": 1942.89, "word": " أنا", "probability": 0.63037109375}, {"start": 1942.89, "end": 1943.47, "word": " بقدر", "probability": 0.9921875}, {"start": 1943.47, "end": 1943.95, "word": " اعرف", "probability": 0.8255208333333334}, {"start": 1943.95, "end": 1944.75, "word": " تركيز", "probability": 0.9793701171875}, {"start": 1944.75, "end": 1946.15, "word": " الكلسترول", "probability": 0.76826171875}, {"start": 1946.15, "end": 1946.51, "word": " اللي", "probability": 0.78125}, {"start": 1946.51, "end": 1947.11, "word": " محمول", "probability": 0.9765625}, {"start": 1947.11, "end": 1948.41, "word": " بالـ", "probability": 0.76318359375}, {"start": 1948.41, "end": 1949.75, "word": " VLDL", "probability": 0.9033203125}], "temperature": 1.0}, {"id": 90, "seek": 196996, "start": 1951.34, "end": 1969.96, "text": "بحكيلي آخر جملة The virtually all of the plasma triglyceride is carried on VLDL كل triglyceride اللي موجودة في البلازمة واللي مصدرها من الكبد تصنعت في الكبد تحمل عن طريق ال VLDL", "tokens": [49628, 4117, 1829, 20292, 19753, 34740, 10874, 2304, 37977, 440, 14103, 439, 295, 264, 22564, 35386, 356, 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التانية", "probability": 0.9798177083333334}, {"start": 2220.83, "end": 2221.09, "word": " أو", "probability": 0.9306640625}, {"start": 2221.09, "end": 2221.57, "word": " الحالة", "probability": 0.9915364583333334}, {"start": 2221.57, "end": 2222.01, "word": " الأولى", "probability": 0.9752604166666666}, {"start": 2222.01, "end": 2222.21, "word": " لو", "probability": 0.95361328125}, {"start": 2222.21, "end": 2222.35, "word": " ان", "probability": 0.8447265625}, {"start": 2222.35, "end": 2222.91, "word": " وجدت", "probability": 0.8400065104166666}, {"start": 2222.91, "end": 2223.47, "word": " واحدة", "probability": 0.9876302083333334}, {"start": 2223.47, "end": 2223.97, "word": " منهم", "probability": 0.993896484375}], "temperature": 1.0}, {"id": 102, "seek": 225081, "start": 2224.85, "end": 2250.81, "text": "ساعتها ممنوع تستخدم الـ Fredwald equation ممنوع ممنوع أستخدم المعادلة فلازم أحسب تركيز الكوليسترول اللي موجود في الـ LDL بطريقة الـ KET مش بالمعادلة سريعا، تمام؟ يا جماعة لما كنت أحكيلكم Normal Range للـ HDL لازم يكون أعلى من 60 ملي جرام per deciliter", "tokens": [3794, 995, 34268, 11296, 3714, 27842, 45367, 6055, 14851, 9778, 40448, 2423, 39184, 10112, 33262, 5367, 3714, 27842, 45367, 3714, 27842, 45367, 5551, 14851, 9778, 40448, 9673, 3615, 18513, 37977, 6156, 1211, 31377, 2304, 5551, 5016, 35457, 6055, 31747, 1829, 11622, 33251, 12610, 1829, 14851, 2288, 12610, 13672, 1829, 3714, 29245, 23328, 8978, 2423, 39184, 33936, 43, 4724, 9566, 16572, 28671, 2423, 39184, 591, 4850, 37893, 20666, 2304, 3615, 18513, 37977, 8608, 16572, 3615, 995, 12399, 46811, 10943, 22807, 35186, 10874, 15042, 27884, 5296, 15042, 9122, 29399, 5551, 5016, 4117, 1829, 23275, 2304, 21277, 33778, 24976, 39184, 12149, 43, 5296, 31377, 2304, 7251, 30544, 5551, 3615, 23942, 9154, 4060, 3714, 20292, 10874, 2288, 10943, 680, 979, 388, 1681], "avg_logprob": -0.15572478365497427, "compression_ratio": 1.5914396887159532, "no_speech_prob": 4.172325134277344e-07, "words": [{"start": 2224.85, "end": 2225.47, "word": "ساعتها", "probability": 0.8651123046875}, {"start": 2225.47, "end": 2225.87, "word": " ممنوع", "probability": 0.9142252604166666}, {"start": 2225.87, "end": 2226.53, "word": " تستخدم", "probability": 0.9793701171875}, {"start": 2226.53, "end": 2226.77, "word": " الـ", "probability": 0.6895751953125}, {"start": 2226.77, "end": 2227.37, "word": " Fredwald", "probability": 0.554931640625}, {"start": 2227.37, "end": 2228.25, "word": " equation", "probability": 0.75146484375}, {"start": 2228.25, "end": 2229.07, "word": " ممنوع", "probability": 0.9228515625}, {"start": 2229.07, "end": 2229.97, "word": " ممنوع", "probability": 0.8587239583333334}, {"start": 2229.97, "end": 2230.63, "word": " أستخدم", "probability": 0.8946533203125}, {"start": 2230.63, "end": 2231.45, "word": " المعادلة", "probability": 0.9949951171875}, {"start": 2231.45, "end": 2232.95, "word": " فلازم", "probability": 0.9296875}, {"start": 2232.95, "end": 2233.71, "word": " أحسب", "probability": 0.9734700520833334}, {"start": 2233.71, "end": 2234.29, "word": " تركيز", "probability": 0.98779296875}, {"start": 2234.29, "end": 2235.13, "word": " الكوليسترول", "probability": 0.9149576822916666}, {"start": 2235.13, "end": 2235.45, "word": " اللي", "probability": 0.834716796875}, {"start": 2235.45, "end": 2235.95, "word": " موجود", "probability": 0.9851888020833334}, {"start": 2235.95, "end": 2236.13, "word": " في", "probability": 0.93798828125}, {"start": 2236.13, "end": 2236.39, "word": " الـ", "probability": 0.956787109375}, {"start": 2236.39, "end": 2237.21, "word": " LDL", "probability": 0.907958984375}, {"start": 2237.21, "end": 2238.17, "word": " بطريقة", "probability": 0.93359375}, {"start": 2238.17, "end": 2238.45, "word": " الـ", "probability": 0.894287109375}, {"start": 2238.45, "end": 2238.77, "word": " KET", "probability": 0.43896484375}, {"start": 2238.77, "end": 2239.29, "word": " مش", "probability": 0.7783203125}, {"start": 2239.29, "end": 2240.27, "word": " بالمعادلة", "probability": 0.99111328125}, {"start": 2240.27, "end": 2240.91, "word": " سريعا،", "probability": 0.774755859375}, {"start": 2240.91, "end": 2241.99, "word": " تمام؟", "probability": 0.9637044270833334}, {"start": 2241.99, "end": 2242.17, "word": " يا", "probability": 0.96337890625}, {"start": 2242.17, "end": 2242.49, "word": " جماعة", "probability": 0.99462890625}, {"start": 2242.49, "end": 2242.69, "word": " لما", "probability": 0.765869140625}, {"start": 2242.69, "end": 2243.01, "word": " كنت", "probability": 0.95361328125}, {"start": 2243.01, "end": 2243.67, "word": " أحكيلكم", "probability": 0.9130045572916666}, {"start": 2243.67, "end": 2244.11, "word": " Normal", "probability": 0.4697265625}, {"start": 2244.11, "end": 2244.81, "word": " Range", "probability": 0.83984375}, {"start": 2244.81, "end": 2245.67, "word": " للـ", "probability": 0.84619140625}, {"start": 2245.67, "end": 2246.61, "word": " HDL", "probability": 0.6666259765625}, {"start": 2246.61, "end": 2247.21, "word": " لازم", "probability": 0.9908854166666666}, {"start": 2247.21, "end": 2247.55, "word": " يكون", "probability": 0.991455078125}, {"start": 2247.55, "end": 2248.09, "word": " أعلى", "probability": 0.93359375}, {"start": 2248.09, "end": 2248.29, "word": " من", "probability": 0.9853515625}, {"start": 2248.29, "end": 2248.83, "word": " 60", "probability": 0.90966796875}, {"start": 2248.83, "end": 2249.23, "word": " ملي", "probability": 0.42626953125}, {"start": 2249.23, "end": 2249.69, "word": " جرام", "probability": 0.8702799479166666}, {"start": 2249.69, "end": 2249.99, "word": " per", "probability": 0.7578125}, {"start": 2249.99, "end": 2250.81, "word": " deciliter", "probability": 0.6878255208333334}], "temperature": 1.0}, {"id": 103, "seek": 225855, "start": 2252.29, "end": 2258.55, "text": "تركيز الـ Cholesterol الموجود أو المحمول في الـ HDL", "tokens": [2655, 31747, 1829, 11622, 2423, 39184, 761, 401, 21947, 9673, 29245, 23328, 34051, 9673, 35571, 12610, 8978, 2423, 39184, 12149, 43], "avg_logprob": -0.3004261282357303, "compression_ratio": 1.1111111111111112, "no_speech_prob": 0.0, "words": [{"start": 2252.29, "end": 2253.69, "word": "تركيز", "probability": 0.86212158203125}, {"start": 2253.69, "end": 2254.03, "word": " الـ", "probability": 0.6007080078125}, {"start": 2254.03, "end": 2254.87, "word": " Cholesterol", "probability": 0.6136067708333334}, {"start": 2254.87, "end": 2256.21, "word": " الموجود", "probability": 0.654541015625}, {"start": 2256.21, "end": 2256.49, "word": " أو", "probability": 0.67041015625}, {"start": 2256.49, "end": 2257.41, "word": " المحمول", "probability": 0.9093424479166666}, {"start": 2257.41, "end": 2257.59, "word": " في", "probability": 0.88720703125}, {"start": 2257.59, "end": 2257.81, "word": " الـ", "probability": 0.952880859375}, {"start": 2257.81, "end": 2258.55, "word": " HDL", "probability": 0.83837890625}], "temperature": 1.0}, {"id": 104, "seek": 228757, "start": 2260.05, "end": 2287.57, "text": "ولمّا أحكي لكم إن تركيز الـ LDL أقل من 100 ميلي جرام per deciliter يعني تركيز الكوليسترول اللي محمول جوات الـ LDL لازم يكون أقل من 100 ميلي جرام per deciliter بس حبيت أنبه لهذه الشغلة إن أنا بقيس تركيز الكوليسترول اللي موجودة في النواقل تمام؟ يعطيكم العافية", "tokens": [12610, 2304, 11703, 995, 5551, 5016, 4117, 1829, 5296, 24793, 36145, 6055, 31747, 1829, 11622, 2423, 39184, 33936, 43, 5551, 4587, 1211, 9154, 2319, 3714, 1829, 20292, 10874, 2288, 10943, 680, 979, 388, 1681, 37495, 22653, 6055, 31747, 1829, 11622, 33251, 12610, 1829, 14851, 2288, 12610, 13672, 1829, 3714, 35571, 12610, 10874, 2407, 9307, 2423, 39184, 33936, 43, 5296, 31377, 2304, 7251, 30544, 5551, 4587, 1211, 9154, 2319, 3714, 1829, 20292, 10874, 2288, 10943, 680, 979, 388, 1681, 4724, 3794, 11331, 21292, 2655, 14739, 3555, 3224, 46740, 24192, 25124, 17082, 37977, 36145, 41850, 4724, 38436, 3794, 6055, 31747, 1829, 11622, 33251, 12610, 1829, 14851, 2288, 12610, 13672, 1829, 3714, 29245, 23328, 3660, 8978, 28239, 14407, 4587, 1211, 46811, 10943, 22807, 37495, 9566, 1829, 24793, 18863, 31845, 10632], "avg_logprob": -0.15979004418477416, "compression_ratio": 1.959090909090909, "no_speech_prob": 5.364418029785156e-07, "words": [{"start": 2260.05, "end": 2260.49, "word": "ولمّا", "probability": 0.7703857421875}, {"start": 2260.49, "end": 2260.91, "word": " أحكي", "probability": 0.93408203125}, {"start": 2260.91, "end": 2261.19, "word": " لكم", "probability": 0.7266845703125}, {"start": 2261.19, "end": 2261.55, "word": " إن", "probability": 0.5546875}, {"start": 2261.55, "end": 2262.27, "word": " تركيز", "probability": 0.9541015625}, {"start": 2262.27, "end": 2262.57, "word": " الـ", "probability": 0.893798828125}, {"start": 2262.57, "end": 2263.27, "word": " LDL", "probability": 0.865478515625}, {"start": 2263.27, "end": 2263.99, "word": " أقل", "probability": 0.8564453125}, {"start": 2263.99, "end": 2264.27, "word": " من", "probability": 0.99072265625}, {"start": 2264.27, "end": 2264.81, "word": " 100", "probability": 0.755859375}, {"start": 2264.81, "end": 2265.23, "word": " ميلي", "probability": 0.52978515625}, {"start": 2265.23, "end": 2265.61, "word": " جرام", "probability": 0.91357421875}, {"start": 2265.61, "end": 2265.83, "word": " per", "probability": 0.60498046875}, {"start": 2265.83, "end": 2266.77, "word": " deciliter", "probability": 0.6846516927083334}, {"start": 2266.77, "end": 2267.59, "word": " يعني", "probability": 0.868408203125}, {"start": 2267.59, "end": 2268.37, "word": " تركيز", "probability": 0.99169921875}, {"start": 2268.37, "end": 2269.41, "word": " الكوليسترول", "probability": 0.9249674479166666}, {"start": 2269.41, "end": 2270.07, "word": " اللي", "probability": 0.82763671875}, {"start": 2270.07, "end": 2270.73, "word": " محمول", "probability": 0.9762369791666666}, {"start": 2270.73, "end": 2271.39, "word": " جوات", "probability": 0.6009928385416666}, {"start": 2271.39, "end": 2271.71, "word": " الـ", "probability": 0.916015625}, {"start": 2271.71, "end": 2272.27, "word": " LDL", "probability": 0.866943359375}, {"start": 2272.27, "end": 2272.77, "word": " لازم", "probability": 0.9874674479166666}, {"start": 2272.77, "end": 2273.05, "word": " يكون", "probability": 0.991455078125}, {"start": 2273.05, "end": 2273.71, "word": " أقل", "probability": 0.9892578125}, {"start": 2273.71, "end": 2273.93, "word": " من", "probability": 0.9951171875}, {"start": 2273.93, "end": 2274.37, "word": " 100", "probability": 0.85693359375}, {"start": 2274.37, "end": 2274.97, "word": " ميلي", "probability": 0.91943359375}, {"start": 2274.97, "end": 2275.39, "word": " جرام", "probability": 0.98876953125}, {"start": 2275.39, "end": 2275.59, "word": " per", "probability": 0.9462890625}, {"start": 2275.59, "end": 2276.43, "word": " deciliter", "probability": 0.8229166666666666}, {"start": 2276.43, "end": 2277.03, "word": " بس", "probability": 0.89501953125}, {"start": 2277.03, "end": 2277.53, "word": " حبيت", "probability": 0.904296875}, {"start": 2277.53, "end": 2278.03, "word": " أنبه", "probability": 0.91796875}, {"start": 2278.03, "end": 2278.57, "word": " لهذه", "probability": 0.946533203125}, {"start": 2278.57, "end": 2279.39, "word": " الشغلة", "probability": 0.7683919270833334}, {"start": 2279.39, "end": 2279.77, "word": " إن", "probability": 0.4716796875}, {"start": 2279.77, "end": 2280.13, "word": " أنا", "probability": 0.5078125}, {"start": 2280.13, "end": 2281.01, "word": " بقيس", "probability": 0.8707682291666666}, {"start": 2281.01, "end": 2281.95, "word": " تركيز", "probability": 0.995849609375}, {"start": 2281.95, "end": 2282.81, "word": " الكوليسترول", "probability": 0.9666341145833334}, {"start": 2282.81, "end": 2283.45, "word": " اللي", "probability": 0.962646484375}, {"start": 2283.45, "end": 2284.15, "word": " موجودة", "probability": 0.9822998046875}, {"start": 2284.15, "end": 2284.35, "word": " في", "probability": 0.9892578125}, {"start": 2284.35, "end": 2285.55, "word": " النواقل", "probability": 0.768096923828125}, {"start": 2285.55, "end": 2286.57, "word": " تمام؟", "probability": 0.7760416666666666}, {"start": 2286.57, "end": 2287.03, "word": " يعطيكم", "probability": 0.950439453125}, {"start": 2287.03, "end": 2287.57, "word": " العافية", "probability": 0.9837239583333334}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2291.2290625, "duration_after_vad": 2233.8662499999928}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/UjIhn24JqWE_raw.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/UjIhn24JqWE_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..27675f77d3217d95cfb836a4c1d9d1607761308e
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/UjIhn24JqWE_raw.srt
@@ -0,0 +1,1696 @@
+1
+00:00:00,860 --> 00:00:04,700
+لـ specimen and storage العينة Total bilirubin
+
+2
+00:00:04,700 --> 00:00:08,820
+determinations using a diazo method require either
+
+3
+00:00:08,820 --> 00:00:13,220
+serum or plasma عينتي سيرم أو بلازمة اسم الطريقة
+
+4
+00:00:13,220 --> 00:00:17,620
+لمن خلالها بدنا نفحص ال total bilirubin diazo
+
+5
+00:00:17,620 --> 00:00:22,860
+method تمام؟ bilirubin is very sensitive to and is
+
+6
+00:00:22,860 --> 00:00:26,240
+destroyed by light and heat therefore specimens
+
+7
+00:00:26,240 --> 00:00:30,500
+should be protected from light prior to and during
+
+8
+00:00:31,050 --> 00:00:35,470
+to end during analysis الـ bilirubin هذه مادة
+
+9
+00:00:35,470 --> 00:00:40,550
+كينيائية حساسة جدا لل light يعني أنا لو جبت عينة
+
+10
+00:00:40,550 --> 00:00:45,570
+فيها bilirubin مثلا وسلطت عليها ال light ممكن هذا
+
+11
+00:00:45,570 --> 00:00:51,310
+ال bilirubin كله يتكسر تمام؟إذا الـ Bilirubin هذه
+
+12
+00:00:51,310 --> 00:00:54,990
+المادة الكيميائية بيصيرلها destroy إذا اتعرضت
+
+13
+00:00:54,990 --> 00:01:00,250
+لlight أو لدرجات حرارة عالية عشان هيك عينته لازم
+
+14
+00:01:00,250 --> 00:01:05,910
+أحميها من الإضاءة المباشرة أثناء التحليلمش معنى
+
+15
+00:01:05,910 --> 00:01:09,890
+إضاءة المختبر ممكن تأثرلي على العينة لأ إضاءة
+
+16
+00:01:09,890 --> 00:01:15,250
+المختبر عادية هنا جزده لو انت صلطت إضاءة تمام يعني
+
+17
+00:01:15,250 --> 00:01:18,550
+لو الإضاءة كانت عالية كتير و متصلت على العينة
+
+18
+00:01:18,550 --> 00:01:24,950
+هتأثر Concentrationsmaybe decrease by 30 ل 50% per
+
+19
+00:01:24,950 --> 00:01:28,170
+hour if exposed to direct sunlight يعني أنا لو جبت
+
+20
+00:01:28,170 --> 00:01:32,370
+عينة وعرضتها مباشرة لأشعة الشمس والعينة كان فيها
+
+21
+00:01:32,370 --> 00:01:37,410
+بالي روبن تركيز ال بالي روبن في الساعة هيجل من 30
+
+22
+00:01:37,410 --> 00:01:44,580
+ل 50% يعني كتير حساسة هذه المادة للإضاءة، تمام؟If
+
+23
+00:01:44,580 --> 00:01:48,320
+separated and stored in the dark Serum or Plasma
+
+24
+00:01:48,320 --> 00:01:52,140
+يعني أنا ممكن أفصل الـ Serum و Plasma أحفظ أحفظهم
+
+25
+00:01:52,140 --> 00:01:57,220
+لندة يوم at room temperature سبع أيام في التلاجة
+
+26
+00:01:57,220 --> 00:02:03,800
+أو تلت شهور ممكن أخزنهم على سالب عشر يعنينكمل في
+
+27
+00:02:03,800 --> 00:02:06,860
+الـ specimen and storage هذا الـ slide حكيناها
+
+28
+00:02:06,860 --> 00:02:10,620
+conjugated bilirubin may be determined in either
+
+29
+00:02:10,620 --> 00:02:15,160
+serum or plasma إذا فحص الـ total bilirubin بطلبه
+
+30
+00:02:15,160 --> 00:02:19,580
+سيرم أو بلازمة أيضا فحص ال conjugated bilirubin
+
+31
+00:02:19,580 --> 00:02:24,800
+سيرم أو بلازمة أيضا ال unconjugated bilirubin سيرم
+
+32
+00:02:24,800 --> 00:02:30,340
+أو بلازمة تمام؟Urine samples can be analyzed by
+
+33
+00:02:30,340 --> 00:02:35,240
+direct diazo method برضه يا جماعة ال conjugated
+
+34
+00:02:35,240 --> 00:02:39,900
+bilirubin موجود في ال urine حكينا فممكن أنا أفحص
+
+35
+00:02:39,900 --> 00:02:44,160
+تركيزه في ال urine من خلال طريقة ال diazo method
+
+36
+00:02:44,160 --> 00:02:49,560
+تمام؟ since the polar conjugated bilirubin is not
+
+37
+00:02:49,560 --> 00:02:54,300
+protein bound and is filtered at the glomerulus
+
+38
+00:02:54,300 --> 00:02:58,220
+and excreted into the urineهذا الـ Conjugated
+
+39
+00:02:58,220 --> 00:03:02,980
+bilirubin بولر قطبي بدوب في الميّه ما بيرتبط
+
+40
+00:03:02,980 --> 00:03:08,060
+بالبروتين ما بيرتبط بناقل يعني ما بده ناقل في
+
+41
+00:03:08,060 --> 00:03:14,300
+بلازمة الدم بيمشي بشكل free وحكينا جزء منه بيروح
+
+42
+00:03:14,300 --> 00:03:20,040
+على الكدن عشان يتم عمل له filtration وexecration
+
+43
+00:03:20,040 --> 00:03:25,910
+مع اليورين تمام؟ هذا الكلام حكيناه قبل هيكإذا لما
+
+44
+00:03:25,910 --> 00:03:29,230
+بدي أفحص Conjugated بليروبين إما بفحصه في الـ
+
+45
+00:03:29,230 --> 00:03:32,590
+Serum و البلازمة ولو بدي أفحص تركيزه في الـ urine
+
+46
+00:03:32,590 --> 00:03:36,970
+برضه بفحص تركيزه في الـ urine عن طريق الـ Diazo
+
+47
+00:03:36,970 --> 00:03:42,030
+method بطريقة الـ Diazo methodالـ Say Principle
+
+48
+00:03:42,030 --> 00:03:46,910
+مبدأ الفحث ركزوا معي قبل ما نتطلع على السلايدات
+
+49
+00:03:46,910 --> 00:03:51,610
+مثلا لو أنا بدي أجي أفحص الـ conjugated bilirubin
+
+50
+00:03:51,610 --> 00:03:56,750
+اللي موجود في إبلازمة الدم بجيب إبلازمةأكيد جواة
+
+51
+00:03:56,750 --> 00:04:00,610
+البلازمة هيكون الـ Conjugated Bilirubin وبروح أجيب
+
+52
+00:04:00,610 --> 00:04:04,450
+الـ Reagent اللي موجود في الـ Kit اللي بيقيس الـ
+
+53
+00:04:04,450 --> 00:04:08,790
+Conjugated Bilirubin وهذا الـ Reagent طبعا مكوناته
+
+54
+00:04:08,790 --> 00:04:13,490
+مواد كيميائية وأكيد من ضمن مكوناته الميه لكن بدنا
+
+55
+00:04:13,490 --> 00:04:17,680
+نعرف أنه في الـ Reagent مافيAccelerator للتفاعل،
+
+56
+00:04:17,680 --> 00:04:22,520
+ما في محفظ للتفاعل لأنه أنا هنا بدي أقيس الـ
+
+57
+00:04:22,520 --> 00:04:25,800
+Conjugated حكينا لما بدينا نقيس الـ Conjugated
+
+58
+00:04:25,800 --> 00:04:29,280
+بالـ Robin، بالـ Robin المرتبط التفاعل ما بيحتاج
+
+59
+00:04:29,280 --> 00:04:35,420
+إلى تحفيذفاللي بيصير أني بقى أروح أخلط الـ Serum
+
+60
+00:04:35,420 --> 00:04:38,800
+تبع المريض اللي فيه الـ Conjugated Bilirubin مع
+
+61
+00:04:38,800 --> 00:04:44,320
+الـ Reagent ومحصلة التفاعل بنقرأها على الـ
+
+62
+00:04:44,320 --> 00:04:50,340
+Spectrophotometer زي فحص السكر، زي فحص الدهون
+
+63
+00:04:50,340 --> 00:04:53,800
+التلاتية الـ Total Protein عادي، فحصات عادية جدا
+
+64
+00:04:53,800 --> 00:04:59,970
+مبدأها تمام؟ خلصنا من هذه الجثةطيب، لو بدي أقيص
+
+65
+00:04:59,970 --> 00:05:04,190
+الـ Billy-Robin اللي غير مرتبط الـ Unconjugated
+
+66
+00:05:04,190 --> 00:05:08,530
+Billy-Robin بنجيب السيرة، تمام، تبع المريض اللي
+
+67
+00:05:08,530 --> 00:05:13,710
+جواته Unconjugated Billy-Robin وبنجيب كت هذا الـ
+
+68
+00:05:13,710 --> 00:05:17,510
+kit خاص في قياس الـ Unconjugated Billy-Robin يعني
+
+69
+00:05:17,510 --> 00:05:21,530
+كل نوع من الـ Billy-Robin له kit خاص فيه حتى الـ
+
+70
+00:05:21,530 --> 00:05:24,390
+Total Billy-Robin اللي بيجيسهم هما التانين له kit
+
+71
+00:05:24,390 --> 00:05:29,680
+خاص فيه، تمام؟فبنجيب الـ Kit الخاص بقياس الـ
+
+72
+00:05:29,680 --> 00:05:33,660
+Unconjugated Bilirubin أكيد الـ Reagent يحتوي على
+
+73
+00:05:33,660 --> 00:05:38,760
+مواد كيميائية وبيحتوي على ميّه و لازم الـ Reagent
+
+74
+00:05:38,760 --> 00:05:43,140
+هذا اللي بدي يقيث الـ Unconjugated اللي بدي يتفاعل
+
+75
+00:05:43,140 --> 00:05:46,760
+مع الـ Unconjugated Bilirubin لازم يسير أو لازم
+
+76
+00:05:46,760 --> 00:05:52,130
+يكون فيه accelerator يكون فيه محفظ، هنحكي ليشهل
+
+77
+00:05:52,130 --> 00:05:56,770
+جيت بجيب السيرة و بجيب الـ reagent بديرهم مع بعض،
+
+78
+00:05:56,770 --> 00:06:02,270
+بيصير في عندي تفاعل، تمام؟ بيحكيلي إن الـ
+
+79
+00:06:02,270 --> 00:06:06,030
+accelerator اللي موجود في الـ reagent المحفظ عادة
+
+80
+00:06:06,030 --> 00:06:11,030
+بيكون قحول، تمام؟ القحول طب تخيلوا إن هذا الـ
+
+81
+00:06:11,030 --> 00:06:16,430
+reagent مش فيه قحولودرت الـ Reagent على العينة مش
+
+82
+00:06:16,430 --> 00:06:20,890
+هيصير تفاعل بين الـ Unconjugated Billy-Robin وبين
+
+83
+00:06:20,890 --> 00:06:26,310
+الـ Reagent إذا لازم وجود محفز، ليش؟ لأنه يا جماعة
+
+84
+00:06:26,310 --> 00:06:30,890
+الـ Reagent تفاجنا فيه مواد كيميائية وميّه فلما
+
+85
+00:06:30,890 --> 00:06:34,330
+بتدري انت على الـ Serum اللي فيه Unconjugated
+
+86
+00:06:34,330 --> 00:06:38,650
+Billy-Robinحكينا إن هذا النوع من الـ Bilirubin غير
+
+87
+00:06:38,650 --> 00:06:42,450
+دائق في الميّه فإنت لو بتحط الـ Reagent عليه مش
+
+88
+00:06:42,450 --> 00:06:46,650
+هيدوب مش هيرتبطه أصلا مش هيرتبط الـ Reagent بالـ
+
+89
+00:06:46,650 --> 00:06:49,410
+Unconjugated Bilirubin لأن الـ Reagent من ضمن
+
+90
+00:06:49,410 --> 00:06:54,350
+مكوناته الميّه وهذا النوع بدوبش في الميّه عشان هيك
+
+91
+00:06:54,350 --> 00:07:00,290
+لازم كحول جوات الـ Reagent الكحول هتجعل الـ
+
+92
+00:07:00,290 --> 00:07:05,670
+Unconjugated Bilirubin يعني هتوفر وسطملائم للتفاعل
+
+93
+00:07:05,670 --> 00:07:09,690
+و هتخلّي الـ Unconjugated «بيلي روبين» يرتبط مع
+
+94
+00:07:09,690 --> 00:07:14,550
+الـ Reagent ويصير التفاعل، تمام؟إذا ملخص الـ
+
+95
+00:07:14,550 --> 00:07:18,710
+Slider إنه كل فحص الـ Total Bilirubin الـ Direct
+
+96
+00:07:18,710 --> 00:07:22,970
+والـ Indirect Bilirubin كل فحص له kit خاص فيه لو
+
+97
+00:07:22,970 --> 00:07:26,390
+بدي أقيس ال Direct بجيب ال kit تبع ال Direct و
+
+98
+00:07:26,390 --> 00:07:31,350
+بخلط ال serum بال reagent ال reagent ما بيحتوي على
+
+99
+00:07:31,350 --> 00:07:37,270
+أي محفزات لإن ال Direct بدوب في الميه وبالتالي ال
+
+100
+00:07:37,270 --> 00:07:41,390
+reagent من ضمن مكوناته ميه فلو خلطهم هيصير فيه
+
+101
+00:07:41,390 --> 00:07:46,700
+تفاعللكن على العكس الـ Indirect Bilirubin الـ
+
+102
+00:07:46,700 --> 00:07:50,440
+Bilirubin الغير مرتبط من خصائصه إنه ما بدوب في
+
+103
+00:07:50,440 --> 00:07:54,760
+الميّه فلو حطيت على الـ Reagent الـ Reagent أصلا
+
+104
+00:07:54,760 --> 00:07:58,340
+عبارة عن مواد كيميائية وميّه مش هيصير في تفاعل
+
+105
+00:07:58,340 --> 00:08:02,880
+بينهم بتاتا إلا إذا كان الـ Reagent بيحتوي على
+
+106
+00:08:02,880 --> 00:08:09,680
+محفظ والمحفظ هنا كحول الكحول هيجعلالـ Indirect
+
+107
+00:08:09,680 --> 00:08:13,320
+بيلي روبين يتفاعل مع الـ Reagent وبالتالي بنقرأ
+
+108
+00:08:13,320 --> 00:08:17,140
+التفاعل على الـ Spectrophotometer تمام؟ نقرأ الـ
+
+109
+00:08:17,140 --> 00:08:22,860
+slide ع السريع بيلي روبين is normal Serum reacted
+
+110
+00:08:22,860 --> 00:08:27,890
+with diazoreagentالـ Reagent يحتوي على مادة ديازو
+
+111
+00:08:27,890 --> 00:08:34,270
+صلفونيليك أسد Only when alcohol was added هنا طبعا
+
+112
+00:08:34,270 --> 00:08:39,770
+بيحكي بخص هنا ال indirect باليروبين ال باليروبين
+
+113
+00:08:39,770 --> 00:08:44,630
+الغير مرتبط لازم الكحول يكون موجود في الـ Reagent
+
+114
+00:08:45,590 --> 00:08:50,550
+the pigment that reacted in the absence of alcohol
+
+115
+00:08:50,550 --> 00:08:55,870
+was termed direct conjugated هنا قصده لما يكون ال
+
+116
+00:08:55,870 --> 00:09:01,870
+reagent مافيش فيه كحول عادي it mean لما ال reagent
+
+117
+00:09:01,870 --> 00:09:05,370
+مايكونش فيه كحول عادي ال conjugated bilirubin
+
+118
+00:09:05,370 --> 00:09:10,270
+هيتفاعل معاه بكل بساطة the pigment that required
+
+119
+00:09:10,270 --> 00:09:15,800
+the presence of alcohol was termed أما المادةاللي
+
+120
+00:09:15,800 --> 00:09:19,860
+بدها كحول و اللي لازم الكحول يكون موجود في الـ
+
+121
+00:09:19,860 --> 00:09:23,160
+reagent إيش بسميها هذه المادة؟ بسميها الـ indirect
+
+122
+00:09:23,160 --> 00:09:26,980
+bilirubin الـ bilirubin الغير مرتبط هذا بده كحول
+
+123
+00:09:26,980 --> 00:09:32,130
+لازم يكون موجود في الـ reagent تمام؟ليش؟ لأن الـ
+
+124
+00:09:32,130 --> 00:09:36,970
+Unconjugated bilirubin is a non-polar غير كُتبي ما
+
+125
+00:09:36,970 --> 00:09:40,410
+بيدوب في الميّه is not soluble in ميّه، in water
+
+126
+00:09:40,410 --> 00:09:45,590
+وبالتالي لو حطيتهم خلطوا مع الـ reagent مش هيصير
+
+127
+00:09:45,590 --> 00:09:49,230
+فيه تفاعل لأن أصلا التفاجنة الـ reagent مكوناته من
+
+128
+00:09:49,230 --> 00:09:54,270
+ضمن مكوناته الميّه فلازم مادة تعمل التفاعل اللي هي
+
+129
+00:09:54,270 --> 00:10:00,240
+الكحول عشان هيكit will react with diazo reagent
+
+130
+00:10:00,240 --> 00:10:04,900
+only in the presence of an agent يعني فقط هذا ال
+
+131
+00:10:04,900 --> 00:10:09,560
+indirect باليروبين هيتفاعل مع ال reagent إذا كان
+
+132
+00:10:09,560 --> 00:10:14,060
+من ضمن مكونات ال reagent كحول تمام؟ accelerator
+
+133
+00:10:16,220 --> 00:10:20,760
+such as alcohol in which both بيلي روبين and the
+
+134
+00:10:20,760 --> 00:10:25,440
+diazo reagent are soluble ساعتها هذا البيلي روبين
+
+135
+00:10:25,440 --> 00:10:31,400
+هيدوب في ال reagent ويسير عنده التفاعل تمام هذا
+
+136
+00:10:31,400 --> 00:10:35,680
+مبدأ التفاعل بكل بساطة قاعد السيران مع ال reagent
+
+137
+00:10:35,680 --> 00:10:38,720
+و بعطيني التفاعل بس أهم الشيء لما بدك تفحص ال
+
+138
+00:10:38,720 --> 00:10:41,880
+indirect ال reagent تبعه بدي يكون فيه كحول بدي
+
+139
+00:10:41,880 --> 00:10:46,650
+يكون فيه acceleratorالبروسيجر for Total Billy
+
+140
+00:10:46,650 --> 00:10:49,710
+-Robin فحص الـ Total Billy-Robin إله كت خاص فيه
+
+141
+00:10:49,710 --> 00:10:53,790
+أكيد هنشتغله إن شاء الله بالجامعة زي ما هو مكتوب
+
+142
+00:10:53,790 --> 00:10:59,210
+عندنا هنتبع نجيب أربع أنابيب نعمل label انبوبة
+
+143
+00:10:59,210 --> 00:11:03,850
+هسميها reagent blank انبوبة هسميها sample blank
+
+144
+00:11:03,850 --> 00:11:08,450
+انبوبة هسميها sample وانبوبة هسميها standard تمام؟
+
+145
+00:11:09,700 --> 00:11:13,020
+كل واحدة إيش وظيفتها هذا هنحكيه في المعمل إن شاء
+
+146
+00:11:13,020 --> 00:11:16,880
+الله الأنبوبة الأولى الـ Reagent Blank إيش بحط
+
+147
+00:11:16,880 --> 00:11:22,300
+فيها؟ بحط فيها واحد ML Working Reagent مع 100
+
+148
+00:11:22,300 --> 00:11:27,260
+مايكرون ديستالد ووتر وهذه الأنبوبة فقط أنا هصفر
+
+149
+00:11:27,260 --> 00:11:32,340
+عليها في الجهاز مش هاخد منها أي فايدة فقط للتصفير
+
+150
+00:11:32,340 --> 00:11:37,120
+تمام؟ اللي سمنها Blank بس هنا كاتب Reagent Blank
+
+151
+00:11:37,120 --> 00:11:43,130
+تمامالأنبوبة التالتة اسمها San Del Blanc هحط فيها
+
+152
+00:11:47,570 --> 00:11:53,090
+أنبوبة الـ Sample Blank بنحط فيها واحد أنقل من
+
+153
+00:11:53,090 --> 00:11:58,370
+Reagent اسمه بيجي في الـ Kit اسمه Reagent A Total
+
+154
+00:11:58,370 --> 00:12:03,810
+تمام؟ التي اختصار لـ Total وعالـ Sample Blank بقى
+
+155
+00:12:03,810 --> 00:12:08,690
+حط 100 ميكروليتر من ال patient sample من عينة
+
+156
+00:12:08,690 --> 00:12:13,780
+المريض من الـ Serum أو البلازمة تمام؟الأنبوبة
+
+157
+00:12:13,780 --> 00:12:17,780
+التالتة حكينا بعملها labeling و بكتب عليها ال
+
+158
+00:12:17,780 --> 00:12:22,160
+patient sample تختلف عن ال sample بلانك patient
+
+159
+00:12:22,160 --> 00:12:27,860
+sample باخد 1 ml من ال working reagent هنحضره مع
+
+160
+00:12:27,860 --> 00:12:35,020
+بعض و فوق ال 1 ml هحط 100 microliter أيضا من ال
+
+161
+00:12:35,020 --> 00:12:39,680
+patient sampleإذا في أمبوبة الـ Sample بـ Blank و
+
+162
+00:12:39,680 --> 00:12:44,840
+أمبوبة الـ Patient Sample حطيت 100 ميكروليتر من
+
+163
+00:12:44,840 --> 00:12:50,440
+عينة المريض على الأمبوب تانية، تمام؟ أمبوبة الـ
+
+164
+00:12:50,440 --> 00:12:54,180
+Standard كنا عارفين واحد أنقل من Working Reagent
+
+165
+00:12:54,180 --> 00:12:58,700
+مع 100 ميكروليتر من علبة الـ Standard اللي بتكون
+
+166
+00:12:58,700 --> 00:13:03,940
+جاية مع الـ Kit وترتيب الـ Total Billy Robin بيكون
+
+167
+00:13:03,940 --> 00:13:08,990
+موجود على أمبوبة الـ Standardبعمل mix للأربع
+
+168
+00:13:08,990 --> 00:13:13,190
+قنابيب وبتركهم incubation two minute at room
+
+169
+00:13:13,190 --> 00:13:17,790
+temperature بعد هيك بقطبط جهاز الـ Spectro على
+
+170
+00:13:17,790 --> 00:13:25,750
+خمسمية وأربعين نانو مترركزوا معي كيف هشتغل هجيب
+
+171
+00:13:25,750 --> 00:13:30,190
+ديستالد ووتر عادي و أحطه في الجهاز و أضغط ع Zero،
+
+172
+00:13:30,190 --> 00:13:35,550
+أصفر عليه بعد ما أصفر على الـ Distilled Water بروح
+
+173
+00:13:35,550 --> 00:13:39,210
+أجيب أنبوبة الـ Sans Blanc اللي مكتوب عليها Sans
+
+174
+00:13:39,210 --> 00:13:44,250
+Blanc بدخلها في الجهاز و باخد الـ Absorbance لها،
+
+175
+00:13:44,250 --> 00:13:48,450
+تمام؟ إذا الـ Absorbance للـ Sans Blanc بنسجله
+
+176
+00:13:48,450 --> 00:13:53,180
+بالدفتربعد ما اخلص خلاص بنكب انبوبة الـ Sample
+
+177
+00:13:53,180 --> 00:13:58,960
+بلانك و ادنيجي باخد الـ Reagent بلانك بحطه بالـ
+
+178
+00:13:58,960 --> 00:14:03,880
+Cuvete و بدخله في الجهاز و بصفر عليه و بعد ما صفر
+
+179
+00:14:03,880 --> 00:14:09,050
+عليهبروح بدخّل الـ standard و باخد ال absorbance
+
+180
+00:14:09,050 --> 00:14:13,550
+للـ standard و بعدين بدخّل ال sample تاعت المريض
+
+181
+00:14:13,550 --> 00:14:16,410
+ال patient sample انبوبة ال patient sample و
+
+182
+00:14:16,410 --> 00:14:20,630
+باخدلها absorbance إذا هنا زي و زي أي فحص بس في
+
+183
+00:14:20,630 --> 00:14:25,550
+خطوة زيادة إذا انتأول إشي بتصفري على الـReagent
+
+184
+00:14:25,550 --> 00:14:29,710
+Blank بعدين بتدخلي أنبوبة الـStandard وأنبوبة
+
+185
+00:14:29,710 --> 00:14:33,490
+الـPatient Sample وبتاخد الـAbsorbance لإلهم بعد
+
+186
+00:14:33,490 --> 00:14:37,010
+هيك بتجيبي Distilled Water بتدخليها على الجهاز
+
+187
+00:14:37,010 --> 00:14:41,410
+وبتصفري عليهابعدين بتدخل الأنبوبة الغريبة هذه اللي
+
+188
+00:14:41,410 --> 00:14:45,330
+هنشوف في العملية شو الفايدة منها اللي هي اسمها الـ
+
+189
+00:14:45,330 --> 00:14:49,510
+Sample Blank بدخلها و برضه باخد ال absorbance لها
+
+190
+00:14:49,510 --> 00:14:52,790
+إذا صار عندي تلاتة absorbance ال absorbance تبع ال
+
+191
+00:14:52,790 --> 00:14:56,570
+standard و تبع ال patient sample و تبع أنبوبة ال
+
+192
+00:14:56,570 --> 00:15:03,660
+sample ال blank تمام؟هل جيت يا جماعة معظم الدكاترة
+
+193
+00:15:03,660 --> 00:15:07,240
+بيعملوا الفحصين مع بعض بيعملوا الـ Total بلي روبان
+
+194
+00:15:07,240 --> 00:15:12,160
+و بيعملوا ال Direct بلي روبان لو بدهم ال indirect
+
+195
+00:15:12,160 --> 00:15:16,540
+بترحوا ال total من ال direct تمام؟ فبطلع تركيز ال
+
+196
+00:15:16,540 --> 00:15:21,060
+indirect بلي روبانفهنا احنا هنشتغل الفحصين هنشتغل
+
+197
+00:15:21,060 --> 00:15:24,740
+فحص الـ Total بالـ European Test و هنشتغل فحص الـ
+
+198
+00:15:24,740 --> 00:15:27,280
+Direct بالـ European Test لأن هذا الـ kit برضه
+
+199
+00:15:27,280 --> 00:15:31,080
+متوافر عندنا بالجامعة فإيش الـ procedure بتروح
+
+200
+00:15:31,080 --> 00:15:35,820
+تجيبي تلاتة قنابي بتعملي labeling لهم reagent
+
+201
+00:15:35,820 --> 00:15:40,060
+blank الأنبوبة الأولى الأنبوبة التانية sample
+
+202
+00:15:40,060 --> 00:15:44,240
+blank والأنبوبة التالتة بنسميها ال sample أو ال
+
+203
+00:15:44,240 --> 00:15:49,200
+patient sample تمام؟في الـ «Reagent Blank» بحط 1
+
+204
+00:15:49,200 --> 00:15:55,220
+ML من الـ «Working Reagent» مع 100 µL ديستالد ووتر
+
+205
+00:15:55,220 --> 00:16:00,180
+الأنبوبة التانية «Standby Blank» بحط 1 ML من الـ
+
+206
+00:16:00,180 --> 00:16:05,680
+«Reagent A Direct» دي اختصار لـ Direct وفوقها بحط
+
+207
+00:16:05,680 --> 00:16:10,800
+100 µL من الـ «Patient Sandal» الأنبوبة التالتة
+
+208
+00:16:10,800 --> 00:16:14,940
+تحت الـ «Patient Sandal» بحط 1 ML من الـ «Working
+
+209
+00:16:14,940 --> 00:16:19,530
+Reagent» فيهاو فوق هميت مايكرو ليتر من ال patient
+
+210
+00:16:19,530 --> 00:16:24,230
+sample وبعمل incubation خمس دقائق على ال water
+
+211
+00:16:24,230 --> 00:16:29,200
+bath يعني على درجة حرارة سبعة وتلاتينإيش بعمل؟
+
+212
+00:16:29,200 --> 00:16:33,200
+بروح أجيب الـReagent Blank بحطه بالـCuvette و
+
+213
+00:16:33,200 --> 00:16:37,740
+بدخله على الجهاز و بصفر عليه، تمام؟ بعدين بروح
+
+214
+00:16:37,740 --> 00:16:42,060
+أجيب الـPatient Sample بحطها بالـCuvette بدخلها و
+
+215
+00:16:42,060 --> 00:16:47,300
+باخد الـabsorbance للـPatient Sample، تمام؟ بعد
+
+216
+00:16:47,300 --> 00:16:53,250
+هيك بجيب Distilled Waterبدخله بالجهاز و بصفر عليه
+
+217
+00:16:53,250 --> 00:16:58,350
+بعدين بجيب انبوبة الـ sand بالـblank بحطها بتوفيت
+
+218
+00:16:58,350 --> 00:17:02,950
+و بدخلها بالجهاز و باخد ال absorbance تبعها إذا
+
+219
+00:17:02,950 --> 00:17:07,550
+هنا هحصل على two absorbance ال absorbanceلأ الـ
+
+220
+00:17:07,550 --> 00:17:11,570
+Sample Blank و الـ Absorbance للـ Patient Standard
+
+221
+00:17:11,570 --> 00:17:15,510
+أما الـ Standard بيقوللي الـ Absorbance للـ
+
+222
+00:17:15,510 --> 00:17:21,770
+Standard هنا هو نفسه هيكون الـ Absorbance اللي
+
+223
+00:17:21,770 --> 00:17:26,410
+موجود أو اللي أنا طلعته بالفحص الأول هو فحص الـ
+
+224
+00:17:26,410 --> 00:17:29,740
+Total Bilirubinمش أنا ماشيت أنبوبة الـ Standard
+
+225
+00:17:29,740 --> 00:17:34,660
+الـ Absorbance تبعها هيكون نفس الـ Absorbance تبع
+
+226
+00:17:34,660 --> 00:17:39,620
+فحص الـ Direct باليروبين عشان هيك مافيش داعي أمشي
+
+227
+00:17:39,620 --> 00:17:46,140
+Standard بالفحص هيك ال procedure التحكيلة هنفهمها
+
+228
+00:17:46,140 --> 00:17:51,780
+أكتر لما نشتغلها بإيدانا هنشوف ال calculation
+
+229
+00:17:51,780 --> 00:17:57,980
+الحسابات عادي جدا يا جماعة بطبق Beer's lawأولاً
+
+230
+00:17:57,980 --> 00:18:01,240
+بدي أحسب تركيز أنا اشتغلت في حسينة الـ Total
+
+231
+00:18:01,240 --> 00:18:05,420
+Bilirubin والـ Direct أول إشي بدي أحسب تركيز الـ
+
+232
+00:18:05,420 --> 00:18:09,320
+Total Bilirubin في ال patient sample إيش هيسوي
+
+233
+00:18:09,320 --> 00:18:16,050
+بطبق Beer's law العادى بس بإضافة بسيطةبتجيب الـ
+
+234
+00:18:16,050 --> 00:18:20,810
+Absorbance للـ Patient Sample جبته من الجهاز بطرحه
+
+235
+00:18:20,810 --> 00:18:25,990
+من الـ Absorbance للـ Sample بلانك تمام؟ هذه
+
+236
+00:18:25,990 --> 00:18:29,490
+الأنبوبة الإضافية اللي أول مرة أصلا نمشيها في
+
+237
+00:18:29,490 --> 00:18:35,390
+الفحوصات بأقسم هذا كله على الـ Absorbance للـ
+
+238
+00:18:35,390 --> 00:18:40,130
+Standardدرب الـ Concentration للـ Standard إذا أنا
+
+239
+00:18:40,130 --> 00:18:43,510
+طلعت الـ Absorbance للـ Patient Sample و للـ
+
+240
+00:18:43,510 --> 00:18:46,890
+Standard و الـ Sample بلانك و الـ Concentration
+
+241
+00:18:46,890 --> 00:18:50,150
+للـ Standard موجودة على علبة الـ Standard اللي
+
+242
+00:18:50,150 --> 00:18:54,490
+موجودة في الـ Kit إذا تطبيق Beer's Law بس فوق في
+
+243
+00:18:54,490 --> 00:18:57,630
+البسط الـ Absorbance للـ Sample بتاعة المريض
+
+244
+00:18:57,630 --> 00:19:02,390
+باترحى من الـ Absorbance تبع انبوبة الـ Sample
+
+245
+00:19:02,390 --> 00:19:06,740
+بلانك، تمام؟بطلع النتيجة والـ concentration بالـ
+
+246
+00:19:06,740 --> 00:19:12,040
+milligram per deciliter هذا الفحص الأول أيضًا
+
+247
+00:19:12,040 --> 00:19:16,760
+الفحص التاني الـ direct bilirubin تركيز الـ
+
+248
+00:19:16,760 --> 00:19:20,660
+bilirubin المرتبط في عينة المريض إيش بيساوي برضه
+
+249
+00:19:20,660 --> 00:19:25,560
+بالطبق الـ Beer's law بس مع إضافة بسيطةتقول الـ
+
+250
+00:19:25,560 --> 00:19:29,500
+Absorbance للـ Patient Sample ناقص الـ Absorbance
+
+251
+00:19:29,500 --> 00:19:33,360
+للـ Sample Blank إذا فقط الإشي الجديد إني بقترح
+
+252
+00:19:33,360 --> 00:19:36,960
+الـ Absorbance تبع الـ Patient Sample من الـ
+
+253
+00:19:36,960 --> 00:19:41,180
+Absorbance تبع الـ Sample Blank على الـ Absorbance
+
+254
+00:19:41,180 --> 00:19:46,360
+للـ Standard درب الـ Concentration للـ Standardالـ
+
+255
+00:19:46,360 --> 00:19:50,500
+Absorbance التفاجنة تبع الـ Standard في فحص الـ
+
+256
+00:19:50,500 --> 00:19:56,780
+Total باليروبين هو نفس الـ Absorbance تبع الـ
+
+257
+00:19:56,780 --> 00:20:00,280
+Standard في فحص الـ Direct عشان هيك في الفحص
+
+258
+00:20:00,280 --> 00:20:05,060
+التاني ما مشينا انبوبة Standard لأنه حكينا نفس الـ
+
+259
+00:20:05,060 --> 00:20:09,240
+Absorbance في الفحصين تمام؟ وهدى النقطة بتحكيلنا
+
+260
+00:20:09,240 --> 00:20:13,290
+هيكجماعة فحص الـ Bilirubin الـ Total والـ Direct
+
+261
+00:20:13,290 --> 00:20:17,870
+أنا بفحص الـ Total، بسجل التركيز والـ Direct برضه
+
+262
+00:20:17,870 --> 00:20:21,650
+بتركيز بالmilligram per deciliter والاتنين بترحهم
+
+263
+00:20:21,650 --> 00:20:26,370
+من بعض، بتطلع لتركيز الـ Indirect Bilirubin الفحص
+
+264
+00:20:26,370 --> 00:20:31,250
+مش سعيد، ولكن شوية بيختلف عن الفحصات الرتونية اللي
+
+265
+00:20:31,250 --> 00:20:34,470
+أخدناها اللي هو السكر والـ Total البروتين ال
+
+266
+00:20:34,470 --> 00:20:39,240
+procedure تبعت شوية مختلفةهنفهمها أكتر لما نشتغلها
+
+267
+00:20:39,240 --> 00:20:42,840
+عملية وأكيد الـ Total و ال Direct من ضمن الفحوصات
+
+268
+00:20:42,840 --> 00:20:47,560
+اللي هنشتغلها خلال الأسبوع الجاية، تمام؟ فاللي مش
+
+269
+00:20:47,560 --> 00:20:51,340
+فاهمة كتير الـ procedure في التسجيل هنعيدها إن شاء
+
+270
+00:20:51,340 --> 00:20:52,120
+الله في المعمل
+
+271
+00:20:55,230 --> 00:20:59,850
+أخر أشياء هنحكي عن الـ Normal Range لـ Billy Robin
+
+272
+00:20:59,850 --> 00:21:04,210
+Test Serum Billy Robin Levels أول أشياء هنا قصدها
+
+273
+00:21:04,210 --> 00:21:08,490
+الـ Normal Total Billy Robin يعني الـ Normal Range
+
+274
+00:21:08,490 --> 00:21:12,370
+لفحص Total Billy Robin يعني لوفحصنا الـ Total
+
+275
+00:21:12,370 --> 00:21:18,030
+bilirubin في بلازمة دم لازم تطلع النتيجة من 0.2 لـ
+
+276
+00:21:18,030 --> 00:21:24,390
+1.8 كانت بالك 0.8 بس الصح 1.8 milligram per
+
+277
+00:21:24,390 --> 00:21:28,470
+deciliter شايفين الكميات جديش قليلة الـ Total
+
+278
+00:21:28,470 --> 00:21:34,290
+bilirubin كله لازم يكون في بلازمة دم من 0.2 لـ 1.8
+
+279
+00:21:35,260 --> 00:21:40,340
+أما الـ Normal Range للـ Indirect Bilirubin من 0.2
+
+280
+00:21:40,340 --> 00:21:44,860
+لـ 0.7 milligram per deciliter برضه كميات very
+
+281
+00:21:44,860 --> 00:21:48,780
+very long الـ Conjugated Bilirubin الـ Normal
+
+282
+00:21:48,780 --> 00:21:54,880
+Range إليه من 0.1 لـ 0.4 milligram per deciliter
+
+283
+00:21:54,880 --> 00:22:00,840
+أخر إشي بيحكيلي Latent Jaundiceتفاجنا إيش هو الـ
+
+284
+00:22:00,840 --> 00:22:05,740
+jaundice حالة مرضية بنسميها السفار أو بدل jaundice
+
+285
+00:22:05,740 --> 00:22:10,780
+بيحكوا اكترس هتاخدوها في النظري اكترس أو jaundice
+
+286
+00:22:10,780 --> 00:22:15,040
+معناها سفار أو يرقان ليش الإنسان بيصير عنده سفار و
+
+287
+00:22:15,040 --> 00:22:20,130
+يرقانوليش الصفار واليارقان مرتبط مع الـ bilirubin
+
+288
+00:22:20,130 --> 00:22:24,650
+نحكي مع بعض تفاجنا إن مادة الـ bilirubin هذه
+
+289
+00:22:24,650 --> 00:22:29,350
+المادة الكيميائية هي pigments زي صفرة صفرة هذه
+
+290
+00:22:29,350 --> 00:22:33,070
+مادة يعني مادة الـ bilirubin إشي أصفر موجود في
+
+291
+00:22:33,070 --> 00:22:38,840
+بلازمة دم تمام؟اتفجنا إنه بيعطي العصارة السفروية
+
+292
+00:22:38,840 --> 00:22:41,760
+اللون الأصفر يعني هو المسئول عن إعطاء العصارة
+
+293
+00:22:41,760 --> 00:22:47,120
+السفروية اللون الأصفر هل جيت الإنسان الطبيعي لو
+
+294
+00:22:47,120 --> 00:22:51,620
+سحبت دم منه وفصلت الدم وطلعت على البلازما تبعته
+
+295
+00:22:51,620 --> 00:22:56,760
+لون البلازما أصفر قش يعني سفار فاتح الـ Serum أو
+
+296
+00:22:56,760 --> 00:23:01,290
+البلازما صح ولا لأ؟ بيكون سفار فاتحهذا إنسان طبيعي
+
+297
+00:23:01,290 --> 00:23:06,190
+تركيز الـ Total بلي روبن عنده من point 2 ل 1.8
+
+298
+00:23:06,190 --> 00:23:11,050
+يعني الإنسان السليم يفترض تركيز الـ Total بلي روبن
+
+299
+00:23:11,050 --> 00:23:16,510
+عنده من point 2 ل 1.8 milligram per deciliter صح
+
+300
+00:23:16,510 --> 00:23:22,520
+ولا لا؟ حتى الإنسان السليم ممنوع أشوف وجهه أصفرأو
+
+301
+00:23:22,520 --> 00:23:28,620
+العين تبعته صفرة كتير أو الـ skin اللي جيه كتير
+
+302
+00:23:28,620 --> 00:23:33,580
+كتير صفار في كل المناطق ممنوع للإنسان السليم ال
+
+303
+00:23:33,580 --> 00:23:39,320
+skin تبعه بدي تكون لونه طبيعي لكن الأشخاص اللي
+
+304
+00:23:39,320 --> 00:23:45,220
+عندهم ارتفاع في ال total Billy Robbins هلاجي عندهم
+
+305
+00:23:45,220 --> 00:23:50,350
+jaundice هلاجي عندهم صفار أو يرقانلو أن الأشخاص
+
+306
+00:23:50,350 --> 00:23:54,030
+اللي عندهم الـ total bilirubin عالي كتير و سحبت
+
+307
+00:23:54,030 --> 00:23:58,730
+منهم عينة وفصلتيها وشفت الـ serum أو البلازمة
+
+308
+00:23:58,730 --> 00:24:03,690
+هتلاقي اللون dark yellow أصفر كتير كتير غامق أصلا
+
+309
+00:24:03,690 --> 00:24:08,010
+أنت بتفصل العينة من جبل ما تحكم إن عنده total
+
+310
+00:24:08,010 --> 00:24:10,790
+bilirubin عالي ولا لأ من الـ serum اللي بتعرفي من
+
+311
+00:24:10,790 --> 00:24:14,820
+اللونبتلاقي لون الـ Serum أصفر غامق، غامق جداً
+
+312
+00:24:14,820 --> 00:24:18,060
+فبتحكي أكيد عنده ارتفاع في الـ total bilirubin
+
+313
+00:24:18,060 --> 00:24:21,860
+لأنه التفاجنة مادة الـ bilirubin مادة صفراء، مادة
+
+314
+00:24:21,860 --> 00:24:25,340
+يعني pigment، أصلاً هي صبغة وبالتالي لما بزيد
+
+315
+00:24:25,340 --> 00:24:32,060
+تركيزها في بلازمة الدمهيزيد اللون تبعها فهتصبغ لـ
+
+316
+00:24:32,060 --> 00:24:36,380
+Plasma هتخليها صفرة كتير وبالتالي هذا الصفار هيأثر
+
+317
+00:24:36,380 --> 00:24:41,660
+على الـ organ تبع الإنسان نتيجة الصفار ونتيجة
+
+318
+00:24:41,660 --> 00:24:45,040
+ارتفاع هذه المادة الكيميائية هي صبغة وبالتالي هذه
+
+319
+00:24:45,040 --> 00:24:49,140
+الصبغة هتبدأ نشوفها بتترسب على ال skin يعني هنشوف
+
+320
+00:24:49,140 --> 00:24:55,230
+لون ال skinأصفر هتشوف العين لو فتحته صور لناس
+
+321
+00:24:55,230 --> 00:24:59,290
+مصابة بـ jaundice برضه هتلاقي فيه صفار عشان هيك يا
+
+322
+00:24:59,290 --> 00:25:04,310
+جماعة إذا بتعرفوا الأطفال اللي بنولده جديد بيكون
+
+323
+00:25:04,310 --> 00:25:08,790
+عندهم صفار صح ولا لأ؟ ليش؟أصلاً بيكون عندهم ارتفاع
+
+324
+00:25:08,790 --> 00:25:12,730
+في الـ bilirubin طب ليش؟ وخاصة الـ unconjugated
+
+325
+00:25:12,730 --> 00:25:15,730
+bilirubin لأن الكبد لسه بيكون مش مقتمل عندهم
+
+326
+00:25:15,730 --> 00:25:20,350
+وبالتالي ما بيقدر يعمل عملية ال conjugation المحص
+
+327
+00:25:20,350 --> 00:25:24,470
+لأن خلايا ال RBCs تتكسر عندهم وال hemoglobin بتكسر
+
+328
+00:25:24,470 --> 00:25:27,910
+فبيطلع عند مين ال unconjugated bilirubin بيكون
+
+329
+00:25:27,910 --> 00:25:32,090
+عندهم عالي كتير وما بيقدروما بيقدر يتحول لكون
+
+330
+00:25:32,090 --> 00:25:36,170
+conjugated لأن الكبد لسه مش مكتمل بس هذه حالة مش
+
+331
+00:25:36,170 --> 00:25:40,450
+مرضية هذه حالة انه عادية يعني عشان هيك لأنهم صغار
+
+332
+00:25:40,450 --> 00:25:46,920
+مولودين يعني جدد موليد جدد وبالتاليبحكيلك صلت
+
+333
+00:25:46,920 --> 00:25:51,320
+عليهم ضوء وخاصة ضوء الأزرق لأن اتفجنا إن الـ Light
+
+334
+00:25:51,320 --> 00:25:55,020
+بيكسر هذا الـ bilirubin تمام؟ بيمنع هذا ال
+
+335
+00:25:55,020 --> 00:26:00,640
+bilirubin يطلع على جدار الدماغ ويخترق الجدار ويعمل
+
+336
+00:26:00,640 --> 00:26:04,080
+مشاكل ممكن يؤدي للوفاء إذا دلوا عالي وبالتالي
+
+337
+00:26:04,080 --> 00:26:09,100
+بنصحونا نعرض الأطفال للضوء تمام؟ إذا نعرفنا إيش
+
+338
+00:26:09,100 --> 00:26:12,860
+ارتباط اليرقان هذا المرض الـ jaundice بارتفاع
+
+339
+00:26:12,860 --> 00:26:17,150
+التتة ال bilirubin وأصلا السببالصفار هو ارتفاع الـ
+
+340
+00:26:17,150 --> 00:26:21,550
+Total Bilirubin لما تلاقي الإنسان أصفر وجهه شاحب،
+
+341
+00:26:21,550 --> 00:26:25,110
+عينيه بتحكي هذا عنده ارتفاع في الـ Bilirubin،
+
+342
+00:26:25,110 --> 00:26:31,030
+تمام؟ فلو الـ Bilirubin يا جماعة كان أعلى من الـ
+
+343
+00:26:31,030 --> 00:26:35,010
+Total Bilirubin لو طلع أعلى من 1 milligram per
+
+344
+00:26:35,010 --> 00:26:39,690
+deciliter معناه دي حالة latent يعني لسه، يعني لسه
+
+345
+00:26:39,690 --> 00:26:44,820
+الصفار بيكون خاننيعني لسه بادي، يعني لسه مش بادي
+
+346
+00:26:44,820 --> 00:26:49,460
+تظهر عليه أعراض السفارة، تمام؟ لكن لما بتطلع الـ
+
+347
+00:26:49,460 --> 00:26:54,140
+Total Billy-Robin أعلى من 2 milligram per
+
+348
+00:26:54,140 --> 00:26:58,620
+deciliter معناها ده أكيد جون ديس، أكيد سفارة، تشخص
+
+349
+00:26:58,620 --> 00:27:02,940
+الحالة أن هذا الشخص عنده يرقان نتيجة ارتفاع الـ
+
+350
+00:27:02,940 --> 00:27:08,840
+Total Billy-Robin، تمام؟Billy Robbins Levels and
+
+351
+00:27:08,840 --> 00:27:13,480
+Jondes تعالوا نشوف ال class of jondes تصنيف
+
+352
+00:27:13,480 --> 00:27:19,020
+اليرقان أو السفارة قسموه لتلت أقسم الـ Pre-Hepatic
+
+353
+00:27:19,020 --> 00:27:23,840
+Jondes أو الـ Hepatic Jondes أو الـ Post-Hepatic
+
+354
+00:27:23,840 --> 00:27:28,160
+Jondes تعالوا نفهم الـ Pre-Hepatic أو بيسموه الـ
+
+355
+00:27:28,160 --> 00:27:34,620
+Hemolytic Jondes يعني هذا السفاراللي عند المريض
+
+356
+00:27:34,620 --> 00:27:40,220
+سببه Hemolysis تكسير في الـ RBCs سببه الـ Pre
+
+357
+00:27:40,220 --> 00:27:43,920
+-Hepatic يعني ما له علاقة في ال liver liver عند
+
+358
+00:27:43,920 --> 00:27:48,200
+هدول الأشخاص سليم و 100% لكن مشكلة الصفار و
+
+359
+00:27:48,200 --> 00:27:52,740
+اليارقان اللي عندهم انه في عندهم Hemolysis إيش
+
+360
+00:27:52,740 --> 00:27:58,240
+أسباب الـ Hemolytic jaundice الصفاريعني السفار من
+
+361
+00:27:58,240 --> 00:28:02,940
+هذا النوع إيش أسبابه؟ أسبابه Abnormal RBCs إنسان
+
+362
+00:28:02,940 --> 00:28:07,320
+بتتصنع عنده RBCs شكلها مثلا مختلف وبالتالي هذه
+
+363
+00:28:07,320 --> 00:28:12,360
+الـRBCs عمرها قصير وبالتالي بتتكسر بسرعة كل ما
+
+364
+00:28:12,360 --> 00:28:16,120
+الـRBCs اتكسرت يعني اللي بتكون، بتكسر، بتكون،
+
+365
+00:28:16,120 --> 00:28:20,160
+بتكسر زي كأنه Hemolytic Anemia معناه هيطلع
+
+366
+00:28:20,160 --> 00:28:25,340
+الـUnconjugated Billy Robin من هذه الـRBCsوهيزيد
+
+367
+00:28:25,340 --> 00:28:30,440
+تركيزه في الدم ويعمل يرقان أو سفار، تمام؟ لأن هذا
+
+368
+00:28:30,440 --> 00:28:33,120
+الـ bilirubin كل أنواع الـ bilirubin هي pigments،
+
+369
+00:28:33,120 --> 00:28:38,840
+هي صبغة، تمام؟ أو في عندي antibodiesأو أدوية،
+
+370
+00:28:38,840 --> 00:28:44,040
+drugs أو toxins كل هذه المواد ممكن تأثر على الـ
+
+371
+00:28:44,040 --> 00:28:49,500
+RBCs أدوية أو سموم أو antibodies ممكن تأثر على الـ
+
+372
+00:28:49,500 --> 00:28:53,880
+RBCs وتعمل Hemolytic Anemia فالـ Hemolytic Anemia
+
+373
+00:28:53,880 --> 00:28:57,470
+يعني الـ RBCs كتيرة بتتكسر يعني Hemoglobinكتير
+
+374
+00:28:57,470 --> 00:29:01,870
+بتكسر يعني خروج للـ Unconjugated bilirubin بكميات
+
+375
+00:29:01,870 --> 00:29:06,850
+كبيرة يعني حدوث اليارقان، تمام؟ حالات الثلاثيميا،
+
+376
+00:29:06,850 --> 00:29:11,030
+برضه عارفين في الثلاثيميا برضه الـ RBCs بتتكسر،
+
+377
+00:29:11,030 --> 00:29:15,370
+الـ RBCs اللي بتتكون بتتكسر بسرعة حالات الـ
+
+378
+00:29:15,370 --> 00:29:18,110
+Hemoglobinopathies المشاكل اللي بتكون في الـ
+
+379
+00:29:18,110 --> 00:29:21,510
+Hemoglobin معناه الـ Hemoglobin برضه هنا فيه
+
+380
+00:29:21,510 --> 00:29:25,050
+مشكلة، هيصيرله تكسير ويطلع منه الـ Unconjugated
+
+381
+00:29:25,050 --> 00:29:29,440
+bilirubinأما يا جماعة الـ Gilbert والـ Crigler
+
+382
+00:29:29,440 --> 00:29:35,160
+Najjar Syndrome أشطبوهم من هنا ونزلوهم تحت نزلوهم
+
+383
+00:29:35,160 --> 00:29:39,400
+وحطوهم في المربع التاني تمام؟
+
+384
+00:29:41,930 --> 00:29:45,830
+إذا في حالات الـ Hemolytic jaundice أو حالات الـ
+
+385
+00:29:45,830 --> 00:29:51,010
+Pre-Hepatic هنا اللي بيزداد هو الـ Unconjugated
+
+386
+00:29:51,010 --> 00:29:55,210
+bilirubin لأن هذه الحالات الكبت سليم بس الـ RBCZ
+
+387
+00:29:55,210 --> 00:29:59,030
+بتتكسر بكميات كبيرة بتطلع منها الـ Unconjugated
+
+388
+00:29:59,030 --> 00:30:05,750
+bilirubin تمام؟ وبيعملي jaundice، سفرأما الحالة
+
+389
+00:30:05,750 --> 00:30:12,290
+التانية سموها Hepatic jaundice صفار سببه مشكلة في
+
+390
+00:30:12,290 --> 00:30:17,730
+الكبد أو Hepatosimilar jaundice صفار سببه مشكلة في
+
+391
+00:30:17,730 --> 00:30:22,050
+خلايا الكبد نفسها هلجت الـ Unconjugated Billy
+
+392
+00:30:22,050 --> 00:30:26,050
+-Robin طلع من الـ RBCs وبده يروح على الكبد عشان
+
+393
+00:30:26,050 --> 00:30:32,010
+بده يتحول عشان بده يتم عملية الربط لإله؟لكن بسبب
+
+394
+00:30:32,010 --> 00:30:36,970
+Viral Hepatitis، فيروس أثر على خلايا الكبد وعمل
+
+395
+00:30:36,970 --> 00:30:41,210
+فيها التهاب أو Toxic Hepatitis، مواد سما أثرت على
+
+396
+00:30:41,210 --> 00:30:44,530
+خلايا الكبد وعملت فيها التهاب Intra-hepatic
+
+397
+00:30:44,530 --> 00:30:48,590
+cholestasis، يعني تكوين حصاوي جواد خلايا الكبد
+
+398
+00:30:49,840 --> 00:30:53,300
+أيضاً ضيفوا عليها الـ Gilbert-Andrey Kriegler
+
+399
+00:30:53,300 --> 00:30:56,700
+نجاري سندروم اللي حكيتلكم احذفوها من فوق ونزلوهم
+
+400
+00:30:56,700 --> 00:31:01,560
+من تحت هذه حالات ورصية كل هذه الحالات بيصير أنا
+
+401
+00:31:01,560 --> 00:31:05,140
+عندي مشكلة في خلايا الكبد نفسها معناه خلايا الكبد
+
+402
+00:31:05,140 --> 00:31:08,540
+مش هتقدر تحول الـ Unconjugated bilirubin
+
+403
+00:31:08,540 --> 00:31:13,480
+لconjugated bilirubin المحصلة أن الـ Unconjugated
+
+404
+00:31:13,480 --> 00:31:18,160
+bilirubinهيزداد تركيزه في الدم ويؤدي إلى Jaundice
+
+405
+00:31:18,160 --> 00:31:22,100
+بس نوع الـ Jaundice Hepatic Jaundice صفار سببه
+
+406
+00:31:22,100 --> 00:31:27,220
+مشكلة في خلايا الكبد إذن الـ Pre-Hepatic والـ
+
+407
+00:31:27,220 --> 00:31:30,800
+Hepatic في الحالتين هدول الـ Unconjugated
+
+408
+00:31:30,800 --> 00:31:34,940
+Bilirubin هو اللي بيرتفع وبيعمل Jaundice بيعمل
+
+409
+00:31:34,940 --> 00:31:40,320
+صفار أو ما يسمى باليرقامآخر إشي الـ Post-hepatic
+
+410
+00:31:40,320 --> 00:31:45,820
+يعني مشاكل ما بعد اللفر Extra-hepatic cholestasis
+
+411
+00:31:45,820 --> 00:31:50,560
+تكوين حصاوي برا الكبد، وين جزده برا؟ يعني في
+
+412
+00:31:50,560 --> 00:31:54,780
+الـBiliary Duct في القناع الصفراوية، تكوين
+
+413
+00:31:54,780 --> 00:32:00,030
+Gallstones، حصاويفي القناة السفرية أو tumors أو
+
+414
+00:32:00,030 --> 00:32:05,770
+cancer في هذه القناة أو cancer في البنكرياس وانتد
+
+415
+00:32:05,770 --> 00:32:09,170
+هذا السرطان على القناة السفرية إذا في ال post
+
+416
+00:32:09,170 --> 00:32:13,110
+-hepatic يعني عندي مشكلة في القناة السفرية هال
+
+417
+00:32:13,110 --> 00:32:18,070
+gate ال conjugated اتكون في ال liver وبده يطلع على
+
+418
+00:32:18,070 --> 00:32:22,800
+الأمعاء عشان يتم خروجه مع ال thesisلكن لاجأ فيه
+
+419
+00:32:22,800 --> 00:32:26,600
+انسداد في القناة الصفرية مش هيقدر يعبر عبرها
+
+420
+00:32:26,600 --> 00:32:31,240
+وبالتالي المحصلة إنه هيرجع على الكبد وبعدها يطلع ع
+
+421
+00:32:31,240 --> 00:32:35,860
+الدم ويزداد تركيزه يعني في حالة الـ Post-Hepatic
+
+422
+00:32:35,860 --> 00:32:40,840
+Jaundice صفار سببه مشكلة في القناة الصفرية أدّل
+
+423
+00:32:40,840 --> 00:32:44,500
+ارتفاع الـ Conjugated Billy-Robin وهو اللي عمل
+
+424
+00:32:44,500 --> 00:32:47,760
+الصفار تمام؟ وبهك يعطيكم ألف عافية
+
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/_KHiyilTHZ0.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/_KHiyilTHZ0.srt
new file mode 100644
index 0000000000000000000000000000000000000000..7df9cee597b7e0877c65fa6b1f2d1ef0304c6e46
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/_KHiyilTHZ0.srt
@@ -0,0 +1,1385 @@
+1
+00:00:00,810 --> 00:00:04,390
+السلام عليكم ورحمة الله وبركاته، يعطيكم العافية
+
+2
+00:00:04,390 --> 00:00:08,790
+جميعًا إن شاء الله، اليوم موضوعنا lipid profiling
+
+3
+00:00:08,790 --> 00:00:14,660
+فحوصات الدهون، نحكي عن الـIntroduction. The major
+
+4
+00:00:14,660 --> 00:00:17,920
+lipids present in the plasma are fatty acids,
+
+5
+00:00:18,080 --> 00:00:20,780
+triglycerides, cholesterol and phospholipids
+
+6
+00:00:20,780 --> 00:00:27,180
+بيحكي لي إنه الدهون الأساسية اللي موجودة في بلازما
+
+7
+00:00:27,180 --> 00:00:32,560
+الدم هي عبارة عن fatty acids، أحماض دهنية،
+
+8
+00:00:32,560 --> 00:00:37,840
+triglycerides، دهون ثلاثية، الكوليسترول كلنا عارفين
+
+9
+00:00:37,840 --> 00:00:42,500
+الكوليسترول، and الـphospholipids، اللي هي دهون مربوطة
+
+10
+00:00:42,500 --> 00:00:47,940
+بـphosphate group. إذا هذه هي الدهون الأساسية اللي
+
+11
+00:00:47,940 --> 00:00:52,440
+موجودة في بلازما الدم. Other lipid-soluble
+
+12
+00:00:52,440 --> 00:00:56,560
+substances present in much smaller amounts. Example:
+
+13
+00:00:56,560 --> 00:01:02,470
+steroid hormones. بيحكي لي إن في هناك مواد، هذه المواد
+
+14
+00:01:02,470 --> 00:01:08,830
+دائبة في الدهون اللي موجودة في بلازما الدم، وهذه
+
+15
+00:01:08,830 --> 00:01:13,210
+الـsubstances اللي دائبة في الدهون موجودة في
+
+16
+00:01:13,210 --> 00:01:18,010
+البلازما بـsmall amounts، بكميات قليلة، وهي
+
+17
+00:01:18,010 --> 00:01:22,250
+الـsteroid hormones. إذًا الـsteroid hormones هذه
+
+18
+00:01:22,250 --> 00:01:27,190
+الهرمونات دائبة في الـlipids اللي بتكون موجودة في
+
+19
+00:01:27,190 --> 00:01:31,910
+البلازما، وتركيز الـsteroid hormones عادة بتكون
+
+20
+00:01:31,910 --> 00:01:36,710
+قليلة في البلازما. Elevated plasma concentrations
+
+21
+00:01:36,710 --> 00:01:40,990
+of lipids, particularly cholesterol, are related to
+
+22
+00:01:40,990 --> 00:01:46,250
+the pathogenesis of atherosclerosis. بيحكي لي ارتفاع
+
+23
+00:01:46,250 --> 00:01:52,050
+مستوى الدهون وتركيز الدهون في البلازما لما بتزيد،
+
+24
+00:01:52,050 --> 00:01:58,830
+وبالأخص الكوليسترول، هذا مرتبط ارتباط وثيق بحدوث
+
+25
+00:01:58,830 --> 00:02:04,550
+تصلب الشرايين. إذا تصلب الشرايين ثبت من أسبابه هو
+
+26
+00:02:04,550 --> 00:02:13,200
+ارتفاع الدهون في بلازما الدم. Lipids transport، نقل
+
+27
+00:02:13,200 --> 00:02:17,660
+الدهون في البلازما. Lipids are carried in the
+
+28
+00:02:17,660 --> 00:02:22,520
+bloodstream by complexes known as lipoproteins.
+
+29
+00:02:22,520 --> 00:02:26,680
+بدنا نعرف هالـgate، لو الإنسان تناول أكل مليان
+
+30
+00:02:26,680 --> 00:02:33,290
+دهون، أو الجسم صنع هذه الدهون، في الآخر الدهون هتكون
+
+31
+00:02:33,290 --> 00:02:37,130
+موجودة في الـbloodstream، في الدم، في الـplasma.
+
+32
+00:02:37,130 --> 00:02:43,030
+هل هذه الدهون، لو بدها تنتقل من الدم إلى أنسجة
+
+33
+00:02:43,030 --> 00:02:47,550
+الجسم، إلى خلايا الجسم، عشان الخلايا أحيانًا تحتاج
+
+34
+00:02:47,550 --> 00:02:53,000
+إلى دهون عشان تشتغل أو عشان تتكون، وبالتالي الدهون
+
+35
+00:02:53,000 --> 00:02:58,160
+insoluble in، غير دائبة في بلازما الدم،
+
+36
+00:02:58,160 --> 00:03:03,320
+وبالتالي ما تقدر الدهون تتحرك بشكل free في
+
+37
+00:03:03,320 --> 00:03:08,380
+البلازما، ما تقدر تمشي لحالها، وبالتالي تحتاج إلى
+
+38
+00:03:08,380 --> 00:03:14,200
+transporters، إلى نواقل، تنقلها من مكان لمكان. نواقل
+
+39
+00:03:14,200 --> 00:03:20,530
+الدهون سمّوها lipoproteins. هي أصلًا النواقل عبارة
+
+40
+00:03:20,530 --> 00:03:25,390
+عن بروتينات، فسمّوها الـlipoproteins، يعني بروتينات
+
+41
+00:03:25,390 --> 00:03:31,640
+تنقل الـlipids. كلمة lipo من الـlipids. إذًا lipids are
+
+42
+00:03:31,640 --> 00:03:35,660
+carried in the bloodstream by complexes known as
+
+43
+00:03:35,660 --> 00:03:41,300
+lipoproteins. الدهون تنقل في الدم من خلال بروتينات،
+
+44
+00:03:41,300 --> 00:03:46,180
+سمّوها هذه البروتينات عبارة عن نواقل، سمّوها الـ
+
+45
+00:03:46,180 --> 00:03:50,520
+lipoproteins، نواقل الدهون. This is because these
+
+46
+00:03:50,520 --> 00:03:54,260
+lipids are not soluble in the plasma water. ليش؟
+
+47
+00:03:54,260 --> 00:04:00,040
+أنا بدي نواقل للدهون، لأن الدهون بطبيعتها لا تذوب
+
+48
+00:04:00,040 --> 00:04:05,460
+في بلازما الدم، ما تقدر تمشي في البلازما بشكل free.
+
+49
+00:04:06,340 --> 00:04:10,400
+Thus, they travel in micelle-like complexes
+
+50
+00:04:10,400 --> 00:04:14,460
+composed of phospholipid, cholesterol and protein
+
+51
+00:04:14,460 --> 00:04:18,560
+on the outside, with cholesterol esters and
+
+52
+00:04:18,560 --> 00:04:23,640
+triglycerides on the inside. هلّأ بيشرح لي شكل
+
+53
+00:04:23,640 --> 00:04:28,860
+النواقل؟ النواقل ببساطة هي بروتينات تنقل الدهون،
+
+54
+00:04:28,860 --> 00:04:33,580
+فسمّوها الـlipoproteins، بروتينات تنقل الليبيد، تنقل
+
+55
+00:04:33,580 --> 00:04:38,560
+الـlipids. هذه الـlipoproteins، هذه النواقل، عادةً شكلها
+
+56
+00:04:38,560 --> 00:04:42,480
+مثل شكل الميسل، بدنا نتخيّلها، إيش يعني الميسل؟ مثل
+
+57
+00:04:42,480 --> 00:04:50,670
+شكل الكرة، تمام؟ هيك مكورة، من برّا، من برّا التركيبة
+
+58
+00:04:50,670 --> 00:04:55,370
+تبعها هي بروتينات، وبالتالي هذه الكورة، الميسل،
+
+59
+00:04:55,370 --> 00:05:02,030
+outside، من برّا، عبارة عن بروتين، تمام؟ وعبارة عن
+
+60
+00:05:02,030 --> 00:05:06,950
+فوسفوليبيد وكوليسترول. إذا التركيبة الخارجية
+
+61
+00:05:06,950 --> 00:05:13,570
+لـlipoproteins، لنواقل الدهون، من برّا تركيبتها
+
+62
+00:05:14,290 --> 00:05:18,910
+البروتين والـphospholipids والكوليسترول، أما من
+
+63
+00:05:18,910 --> 00:05:24,530
+الداخل فهي، من الداخل بتحط الدهون اللي بدها تنقلها،
+
+64
+00:05:24,530 --> 00:05:30,590
+عشان تنقلها من مكان إلى مكان آخر، وبالتالي جواتها
+
+65
+00:05:30,590 --> 00:05:37,430
+إما هيكون، يعني هيكون جوا هذه النواقل كوليسترول و
+
+66
+00:05:37,430 --> 00:05:43,210
+triglycerides. بس الـcholesterol اللي بتنقله بيكون
+
+67
+00:05:43,210 --> 00:05:47,810
+على شكل كوليسترول إيستر. إيش يعني كوليسترول إيستر؟
+
+68
+00:05:47,810 --> 00:05:53,510
+يعني كوليسترول مربوط بـfatty acid، بأحماض دهنية
+
+69
+00:05:53,510 --> 00:05:58,650
+بواسطة إيستر بوند. يعني مش كوليسترول free لحاله، لأ،
+
+70
+00:05:58,650 --> 00:06:03,990
+إنما كوليسترول مع fatty acid، مربوطين مع بعض بإيستر
+
+71
+00:06:03,990 --> 00:06:09,310
+بوند. هيكون جوا هذه النواقل، و triglycerides برضه
+
+72
+00:06:09,310 --> 00:06:13,110
+هي الدهون
+
+73
+00:06:13,110 --> 00:06:20,170
+الثلاثية. إذا تركيبة الـlipoproteins، تركيبة النواقل،
+
+74
+00:06:20,170 --> 00:06:26,860
+كالتالي: من برّا الـmembrane تبعها عبارة عن بروتين و
+
+75
+00:06:26,860 --> 00:06:32,820
+phospholipids وكوليسترول، ومن جوا بتنقل الدهون اللي
+
+76
+00:06:32,820 --> 00:06:37,780
+بدها تنقلها، بتنقل triglycerides وبتنقل
+
+77
+00:06:37,780 --> 00:06:41,560
+cholesterol esters. هذه الدهون الأساسية اللي لازمة
+
+78
+00:06:41,560 --> 00:06:48,860
+للخلايا، اللي لازمة تنقل من الدم للخلايا، تمام؟ الـ
+
+79
+00:06:48,860 --> 00:06:53,720
+four main types of lipoproteins are: chylomicrons,
+
+80
+00:06:53,720 --> 00:06:59,940
+VLDL, LDL and HDL. الأنواع، نواقل الدهون عبارة عن
+
+81
+00:06:59,940 --> 00:07:03,660
+أربعة نواقل. النواقل الأول بنسميه chylomicrons،
+
+82
+00:07:03,660 --> 00:07:07,360
+النواقل الثاني بنسميه الـvery low density
+
+83
+00:07:07,360 --> 00:07:12,180
+lipoproteins. النواقل الثالث الـlow-density
+
+84
+00:07:12,180 --> 00:07:16,260
+lipoproteins. والنواقل الرابع الـhigh-density
+
+85
+00:07:16,260 --> 00:07:21,880
+lipoproteins. هذه كلها نواقل للـlipids، الدهون،
+
+86
+00:07:21,880 --> 00:07:28,020
+وبالأخص هذه النواقل هي اللي بتنقل الكوليسترول esters
+
+87
+00:07:28,020 --> 00:07:34,540
+والـtriglycerides، تمام؟ أهمية الفحص لـclinical
+
+88
+00:07:34,540 --> 00:07:38,900
+significance. الكوليسترول والـtriglycerides، مثل
+
+89
+00:07:38,900 --> 00:07:42,860
+العديد من الأشياء الأساسية للجسم، تدفع اهتمام
+
+90
+00:07:42,860 --> 00:07:48,340
+كلينيكي، عندما يتواجد بتركيزات غير عادية. بيحكي لي هنا
+
+91
+00:07:48,340 --> 00:07:54,260
+هنا إن الكوليسترول والـtriglycerides هذه دهون
+
+92
+00:07:54,260 --> 00:07:59,940
+أساسية، بيحتاجها الجسم وخلايا الجسم، وبالتالي لأنها
+
+93
+00:07:59,940 --> 00:08:06,100
+أساسية، فأي تغيير في تركيز هذه الـlipids، يؤدي ذلك
+
+94
+00:08:06,100 --> 00:08:11,520
+إلى حدوث مشاكل، تمام؟ عادةً يحدث انحراف أو انحراف عن
+
+95
+00:08:11,520 --> 00:08:16,640
+المستوى بسبب غلطات في التنظيم والتنظيم
+
+96
+00:08:16,640 --> 00:08:18,380
+والتنظيم، والتّنظيم، والتّنظيم، والتّنظيم،
+
+97
+00:08:18,380 --> 00:08:19,800
+والتنظيم، والتّنظيم، والتّنظيم، والتّنظيم،
+
+98
+00:08:19,800 --> 00:08:23,000
+والتنظيم، والتّنظيم، والتّنظيم، والتّنظيم، هنا
+
+99
+00:08:23,000 --> 00:08:28,220
+بيحكي لي إن الزيادة أو النقصان في هذه الـlipids،
+
+100
+00:08:28,220 --> 00:08:33,560
+إما بيكون السبب، يعني شو أسباب إن الـlipids بتزيد
+
+101
+00:08:33,560 --> 00:08:38,680
+أو تنقص عند شخص معيّن؟ إما يكون عندي مشكلة في الـ
+
+102
+00:08:38,680 --> 00:08:41,440
+synthesis، في تصنيع هذه الـlipids، أو بالـ
+
+103
+00:08:41,440 --> 00:08:46,240
+degradation، بتحطيمها، أو بالـtransporters نفسها، أو
+
+104
+00:08:46,240 --> 00:08:50,500
+بنواقل الـlipids نفسها، اللي هم الـlipoproteins،
+
+105
+00:08:51,040 --> 00:08:55,820
+ممكن يكون فيهم مشكلة، فيهم خلل. Increased or
+
+106
+00:08:55,820 --> 00:08:58,920
+decreased plasma lipoproteins are named
+
+107
+00:08:58,920 --> 00:09:03,520
+hyperlipoproteinemia and hypolipoproteinemia
+
+108
+00:09:03,520 --> 00:09:10,680
+respectively. الارتفاع في نواقل الدهون، يعني الارتفاع
+
+109
+00:09:10,680 --> 00:09:15,340
+في الـlipoproteins، بنسمّيها hyperlipoproteinemia،
+
+110
+00:09:15,340 --> 00:09:22,200
+والانخفاض في تركيز نواقل الدهون بنسمّيها
+
+111
+00:09:22,200 --> 00:09:28,320
+الـhypolipoproteinemia. Hyper، ارتفاع، وhypo، انخفاض،
+
+112
+00:09:28,320 --> 00:09:36,070
+lipoproteinemia، يقصد فيها نواقل الدهون. Lipids as
+
+113
+00:09:36,070 --> 00:09:41,090
+biochemical markers of disease. تعتبر الدهون علامة
+
+114
+00:09:41,090 --> 00:09:47,190
+كيميائية لحدوث مرض معيّن. Clinical chemistry
+
+115
+00:09:47,190 --> 00:09:51,190
+laboratories offer many tests for lipid disorders.
+
+116
+00:09:51,190 --> 00:09:57,690
+طبعًا أوجدت المختبرات فحوصات بتشيك على وضع الدهون
+
+117
+00:09:57,690 --> 00:10:02,750
+في الجسم. One of the most common tests is the lipid
+
+118
+00:10:02,750 --> 00:10:07,880
+profile. واحد من أشهر الفحوصات الشائعة عندنا الـ
+
+119
+00:10:07,880 --> 00:10:11,880
+lipid profile. كلمة profile حكينا لكم إياها قبل هيك،
+
+120
+00:10:11,880 --> 00:10:16,240
+أو lipid panel. كلمة panel معناها مجموعة، كلمة
+
+121
+00:10:16,240 --> 00:10:20,600
+profile معناها مجموعة. لما أحكي لك في الـrequest، في
+
+122
+00:10:20,600 --> 00:10:24,080
+الطلب، lipid profile، يكتب لك الدكتور lipid profile،
+
+123
+00:10:24,080 --> 00:10:30,640
+يقصد فيها مجموعة الفحوصات الخاصة بالـlipids، وهم
+
+124
+00:10:30,640 --> 00:10:34,980
+أربعة فحوصات. يعني لما الدكتور يكتب لنا في الـ
+
+125
+00:10:34,980 --> 00:10:38,760
+request تبع المريض lipid profile، يعني بده فحوصات
+
+126
+00:10:38,760 --> 00:10:45,480
+الدهون كلها، وهم أربعة فحوصات، اللي هم: أول فحص الـ
+
+127
+00:10:45,480 --> 00:10:50,400
+triglycerides، الدهون الثلاثية. ثاني فحص الكوليسترول،
+
+128
+00:10:50,400 --> 00:10:57,680
+ثالث فحص الـHDL، اللي هو فحص تركيز الـhigh-density
+
+129
+00:10:57,680 --> 00:11:04,720
+lipoproteins. والـLDL، الـlow-density lipoproteins.
+
+130
+00:11:04,720 --> 00:11:09,100
+إذًا بدنا نفهم مع بعض، كلمة lipid profile معناها
+
+131
+00:11:09,100 --> 00:11:14,940
+فحوصات الدهون، وهم أربعة فحوصات، زي ما كتبت لكم. This
+
+132
+00:11:14,940 --> 00:11:19,540
+panel of tests includes: هذا الـprofile عبارة عن
+
+133
+00:11:19,540 --> 00:11:24,100
+measurement of، قياس لـtriglycerides and
+
+134
+00:11:24,100 --> 00:11:30,310
+الكوليسترول. هي فحص، وقياس الـlow-density
+
+135
+00:11:30,310 --> 00:11:34,950
+lipoprotein cholesterol، الـLDL-C، والـhigh
+
+136
+00:11:34,950 --> 00:11:40,590
+-density lipoprotein cholesterol، الـHDL-C. بدنا
+
+137
+00:11:40,590 --> 00:11:47,460
+نفهم إن الـLDL والـHDL، هذي نواقل الدهون، وبالأخص
+
+138
+00:11:47,460 --> 00:11:52,780
+هذه الـlipoproteins، هذه النواقل، تنقل الكوليسترول
+
+139
+00:11:52,780 --> 00:11:58,580
+بشكل أكبر. في ناس هتسألني، طب تنقل الدهون الثلاثية؟
+
+140
+00:11:58,580 --> 00:12:04,440
+نعم، تنقل الدهون الثلاثية، ولكن هي بشكل أساسي بتنقل لنا
+
+141
+00:12:04,440 --> 00:12:09,660
+الكوليسترول، عشان هيك بيسمّوها HDL وLDL-C، خاصة
+
+142
+00:12:09,660 --> 00:12:14,500
+بالكوليسترول، نواقل بتحمل جواتها الكوليسترول،
+
+143
+00:12:14,500 --> 00:12:19,700
+وبتنقله من البلازما للخلايا. النتائج من نتائج
+
+144
+00:12:19,700 --> 00:12:24,380
+التجارب لهذه الليبيدات، تقدّم مقاييس خطر للحصول على
+
+145
+00:12:24,380 --> 00:12:31,080
+مرض قلبي. طبعًا نتائج الفحوصات الأربعة هذه اللي احنا
+
+146
+00:12:31,080 --> 00:12:37,610
+عددناها، النتائج هتحكم هل هذا الشخص هيكون عنده risk
+
+147
+00:12:37,610 --> 00:12:43,190
+factor لحدوث مرض الـcoronary heart disease، أمراض
+
+148
+00:12:43,190 --> 00:12:47,970
+القلب والأوعية الدموية، لأنه يا جماعة ارتفاع الـ
+
+149
+00:12:47,970 --> 00:12:53,030
+lipids، ارتفاع الدهون في بلازما الدم، مرتبط ارتباط
+
+150
+00:12:53,030 --> 00:12:58,010
+وثيق بحدوث أمراض القلب والأوعية الدموية وتصلب
+
+151
+00:12:58,010 --> 00:13:03,830
+الشرايين. لأن الدهون لما بتزيد في البلازما، تترسب على
+
+152
+00:13:03,830 --> 00:13:09,210
+الأوردة والشرايين، وبتسكر الشريان والوريد، وبالتالي
+
+153
+00:13:09,210 --> 00:13:14,570
+بيبطل فيه تدفق للدم، وبالتالي بيصير عندي أمراض الـ
+
+154
+00:13:14,570 --> 00:13:17,330
+cardiovascular disease، أمراض القلب والأوعية
+
+155
+00:13:17,330 --> 00:13:21,910
+الدموية. طبعًا كيف الدهون بتسبب المرض هذا، ميكانزم
+
+156
+00:13:21,910 --> 00:13:27,510
+كبير، وحنأخذه بالتفصيل، تمام؟ بس بدنا نعرف إن ارتفاع
+
+157
+00:13:27,510 --> 00:13:31,590
+الدهون مرتبط ارتباط وثيق بحدوث أمراض القلب
+
+158
+00:13:31,590 --> 00:13:37,210
+والأوعية الدموية. It is therefore clear that lipid
+
+159
+00:13:37,210 --> 00:13:40,050
+measurements should be made in all patients known
+
+160
+00:13:40,050 --> 00:13:43,690
+to have vascular disease and are at increased
+
+161
+00:13:43,690 --> 00:13:49,500
+risk. يفضل إنّه نعمل فحص الـlipid profile، فحوصات
+
+162
+00:13:49,500 --> 00:13:53,940
+الدهون، للمرضى اللي أصلاً هم بيعانوا من مشاكل في
+
+163
+00:13:53,940 --> 00:13:57,860
+الأوعية الدموية، الـvascular disease، بين فترة و
+
+164
+00:13:57,860 --> 00:14:03,000
+فترة، نشيك عليهم ونعمل لهم الـlipid profile، لإنه لو
+
+165
+00:14:03,000 --> 00:14:08,420
+زادت الدهون عندهم، هتزيد الحالة عندهم، وهتسكر
+
+166
+00:14:08,420 --> 00:14:12,920
+الشرايين والأوردة بشكل أكبر. This plasma lipids
+
+167
+00:14:12,920 --> 00:14:15,960
+should be measured in the individuals with the
+
+168
+00:14:15,960 --> 00:14:20,000
+following. هلّأ يا جماعة، فحص هذه الجملة معناها أنه
+
+169
+00:14:20,000 --> 00:14:26,920
+فحص الـlipid profile، فحوصات الدهون، بتنطلب للحالات
+
+170
+00:14:26,920 --> 00:14:32,940
+التالية: أول حالة، أي شخص عنده coronary heart disease،
+
+171
+00:14:32,940 --> 00:14:36,700
+عنده مشاكل في القلب والأوعية الدموية، لازم بين فترة
+
+172
+00:14:36,700 --> 00:14:40,500
+وفترة نعمل له lipid profile، لأنه لو هذا الشخص
+
+173
+00:14:40,500 --> 00:14:45,840
+الدهون عنده زادت، هتزيد عنده المشكلة، هتزيد مشكلة
+
+174
+00:14:45,840 --> 00:14:49,340
+القلب والأوعية الدموية عنده. الناس اللي عندها
+
+175
+00:14:49,340 --> 
+
+223
+00:18:36,090 --> 00:18:40,610
+بيكون هناك Risk Factor للإصابة بـ Coronary Heart
+
+224
+00:18:40,610 --> 00:18:47,410
+Disease، أو إذا كان الـ HDL أقل من 40 ميلي جرام per
+
+225
+00:18:47,410 --> 00:18:52,690
+ديسميتر. الوضع الطبيعي أن الـ HDL عند الإنسان لازم
+
+226
+00:18:52,690 --> 00:18:58,730
+يكون أعلى من 60 ميلي جرام per ديسميتر. لو
+
+227
+00:18:58,730 --> 00:19:04,150
+كان أقل من 60، هيكون عندنا Risk Factor للإصابة
+
+228
+00:19:04,150 --> 00:19:08,360
+بأمراض القلب. أيضًا، الـ diabetes mellitus، يعني يا
+
+229
+00:19:08,360 --> 00:19:14,120
+جماعة، مش للحفظ هذا الجدول، بس بدنا نفهم أن هذه
+
+230
+00:19:14,120 --> 00:19:17,980
+الحالات، لو وجدت عند الشخص، هيكون عنده risk factor
+
+231
+00:19:17,980 --> 00:19:23,120
+للإصابة بأمراض القلب والأوعية الدموية. لكن لما نحكي
+
+232
+00:19:23,120 --> 00:19:27,900
+negative risk factors، يعني لو وجدت هذه الأمور
+
+233
+00:19:27,900 --> 00:19:32,780
+مش هيصير عندنا أمراض لا بالقلب ولا بالأوعية
+
+234
+00:19:32,780 --> 00:19:37,820
+الدموية. إذا كان الـ HDL cholesterol concentration
+
+235
+00:19:37,820 --> 00:19:41,720
+أعلى أو يساوي 60 milligram per deciliter، هذا
+
+236
+00:19:41,720 --> 00:19:46,120
+ممتاز، هذا الإنسان الطبيعي. أو إذا كان الـ LDL
+
+237
+00:19:46,120 --> 00:19:49,480
+cholesterol أقل من 100 milligram per deciliter، برضه
+
+238
+00:19:49,480 --> 00:19:54,580
+هذا محبب، هذا الـnormal range، تمام؟ وبالتالي مش
+
+239
+00:19:54,580 --> 00:19:58,120
+هيصير عند الشخص أمراض لا بالقلب ولا بالأوعية
+
+240
+00:19:58,120 --> 00:20:05,160
+الدموية. هذا الجدول مش للحفظ، إنما للفهم. هنبدأ في أول
+
+241
+00:20:05,160 --> 00:20:10,540
+نوع من أنواع الدهون اللي بتكون موجودة في الدم لـ
+
+242
+00:20:10,540 --> 00:20:15,280
+Triglycerides. كتير بنسمع عنه، الدهون الثلاثية.
+
+243
+00:20:15,280 --> 00:20:20,540
+glycerol-packed backbone with fatty acids attached by
+
+244
+00:20:20,540 --> 00:20:26,590
+ester bonds. الدهون الثلاثية إيش تركيبها؟ تركيبها
+
+245
+00:20:26,590 --> 00:20:32,210
+three fatty acids، تلت أحماض دهنية مرتبطة مع
+
+246
+00:20:32,210 --> 00:20:38,410
+جليسرول بواسطة ester bonds. هذه هي الدهون الثلاثية.
+
+247
+00:20:40,240 --> 00:20:47,740
+٣ أحماض دهنية مربوطين بالجليسرول بواسطة ester
+
+248
+00:20:47,740 --> 00:20:54,720
+bonds. طبعًا الشكل مش مطلوب نحفظه، ولا مطلوب نعرف
+
+249
+00:20:54,720 --> 00:21:00,150
+تركيب الشكل. الـ sources of triglycerides، إيش مصادر
+
+250
+00:21:00,150 --> 00:21:04,170
+الدهون الثلاثية؟ ليها مصدرين يا جماعة، exogenous
+
+251
+00:21:04,170 --> 00:21:08,770
+sources، مصادر خارجية، و endogenous sources، مصادر
+
+252
+00:21:08,770 --> 00:21:14,270
+داخلية. مصادر خارجية من الـ diet، من الأكل، يعني في
+
+253
+00:21:14,270 --> 00:21:21,570
+كتير أكلات بتكون مليانة دهون ثلاثية. إذا أكلنا، تمام؟
+
+254
+00:21:22,450 --> 00:21:27,610
+إذن المصدر الخارجي للدهون الثلاثية هي من أكل
+
+255
+00:21:27,610 --> 00:21:33,070
+الإنسان، من الـ diet. أما المصدر الداخلي لـ
+
+256
+00:21:33,070 --> 00:21:38,110
+triglycerides، من ال liver، يعني المسئول عن تصنيع
+
+257
+00:21:38,110 --> 00:21:42,950
+الدهون الثلاثية في داخل الجسم هو ال liver. خارج
+
+258
+00:21:42,950 --> 00:21:46,850
+الجسم المصدر من الـ diet. طب بدنا نركز مع بعض، هي
+
+259
+00:21:46,850 --> 00:21:52,710
+نعرفنا لـ triglycerides تركيبه، و عرفنا مصادره. بدي
+
+260
+00:21:52,710 --> 00:21:56,270
+أعرف لـ triglycerides، لما يسير في الدم، الدهون
+
+261
+00:21:56,270 --> 00:22:00,690
+الثلاثية، مين بينقلها للخلايا؟ مش الخلايا أحيانًا
+
+262
+00:22:00,690 --> 00:22:05,510
+تحتاج دهون ثلاثية عشان تشتغل، عشان تتكون، كيف..كيف
+
+263
+00:22:05,510 --> 00:22:08,890
+بتنتقل الدهون الثلاثية في الدم؟ مش حكينا بدها
+
+264
+00:22:08,890 --> 00:22:15,290
+lipoproteins، بدها نواقل، تكون هي بطبيعتها بروتينات
+
+265
+00:22:15,290 --> 00:22:21,820
+تنقلها من مكان لمكان. تمام؟ انتبهوا معايا، إذا كان
+
+266
+00:22:21,820 --> 00:22:27,420
+مصدر الدهون الثلاثية من الأكل، يعني المصدر
+
+267
+00:22:27,420 --> 00:22:32,260
+exogenous، خارجي، هلأ أنت أكلت أكلة مليانة دهون
+
+268
+00:22:32,260 --> 00:22:38,000
+ثلاثية، وصلت هلأ الدهون الثلاثية، مين بيجي
+
+269
+00:22:38,000 --> 00:22:44,630
+ينقلها؟ بينقلها الكايلومايكرون. الكايلومايكرون هو
+
+270
+00:22:44,630 --> 00:22:51,710
+نوع من أنواع نواقل الدهون، وبشكل أساسي بينقل لـ
+
+271
+00:22:51,710 --> 00:22:57,970
+triglycerides اللي بيكون مصدرها خارجي من الـ diet.
+
+272
+00:22:59,650 --> 00:23:04,490
+إذن الـ الكايلومايكرون هو الـ lipoprotein بينقل
+
+273
+00:23:04,490 --> 00:23:11,450
+الـ triglycerides اللي مصدرها من الأكل، تمام؟ هلأ جيت
+
+274
+00:23:11,450 --> 00:23:14,610
+حكينا إن الـ liver بيكون الـ triglycerides
+
+275
+00:23:14,610 --> 00:23:18,850
+وبالتالي بوصل الـ triglycerides على الدم، هلأ جيت
+
+276
+00:23:18,850 --> 00:23:24,690
+الـ triglycerides اللي مصدره من الكبد، مين بينقله؟
+
+277
+00:23:24,690 --> 00:23:31,110
+بينقله ناقل آخر اسمه الـ VLDL، الـ Very Low
+
+278
+00:23:31,110 --> 00:23:36,950
+Density Lipoprotein، بينقل بشكل أساسي لـ
+
+279
+00:23:36,950 --> 00:23:42,110
+triglycerides اللي بيكون مصدره من الكبد، اللي اتصنع
+
+280
+00:23:42,110 --> 00:23:47,510
+فيه الكبد، تمام؟ إذا حسب المصدر تبع الـ
+
+281
+00:23:47,510 --> 00:23:54,320
+triglycerides، بيجي الليبوبروتين وبينقله. إذا كان
+
+282
+00:23:54,320 --> 00:23:58,320
+المصدر من الأكل، مين بينقله؟ الـ chylomicron. إذا كان
+
+283
+00:23:58,320 --> 00:24:02,580
+مصدر الدهون الثلاثية من الكبد، مين اللي هينقله؟ الـ
+
+284
+00:24:02,580 --> 00:24:09,520
+VLDL. لو سألناكم سؤال، الـ VLDL، الـ Very Low Density
+
+285
+00:24:09,520 --> 00:24:14,660
+Lipoprotein، هل هو ناقل فقط لـ triglycerides اللي
+
+286
+00:24:14,660 --> 00:24:20,710
+مصدرها من الكبد؟ لأ، بيحمل cholesterol ولكن بنسبة
+
+287
+00:24:20,710 --> 00:24:25,250
+قليلة، يعني هو بينقل cholesterol كمان، ولكن مش بشكل
+
+288
+00:24:25,250 --> 00:24:30,150
+أساسي، إنما هو بشكل أساسي مصمم للدهون الثلاثية،
+
+289
+00:24:30,150 --> 00:24:33,450
+تمام؟
+
+290
+00:24:33,450 --> 00:24:37,870
+Triglycerides، serum triglycerides measurements
+
+291
+00:24:37,870 --> 00:24:42,790
+are done for the following clinical reasons. هلأ جيت
+
+292
+00:24:42,790 --> 00:24:48,740
+يا جماعة؟ ارتفاع لـ triglycerides في بلازما الدم
+
+293
+00:24:48,740 --> 00:24:55,400
+يسبب pancreatitis، يسبب التهاب في البنكرياس، لأن
+
+294
+00:24:55,400 --> 00:24:59,600
+الدهون لما ترتفع في البلازما، في الدم، ويزيد
+
+295
+00:24:59,600 --> 00:25:05,300
+تركيزها عن الـ range المسموح، بتبدأ تترسب على أعضاء
+
+296
+00:25:05,300 --> 00:25:10,340
+وخلايا الجسم، فبتبدأ الدهون الثلاثية تترسب على
+
+297
+00:25:10,340 --> 00:25:14,940
+البنكرياس، وبتعمل فيه التهاب. إذن الـ hyper
+
+298
+00:25:14,940 --> 00:25:20,540
+triglyceridemia، يعني التهاب، يعني ارتفاع
+
+299
+00:25:20,540 --> 00:25:25,760
+للـ triglycerides في الدم، increases the risk for
+
+300
+00:25:25,760 --> 00:25:33,060
+pancreatitis. إذن يزيد من احتمالية الإصابة بالتهاب
+
+301
+00:25:33,060 --> 00:25:37,260
+البنكرياس. يعني أغلب اللي عندهم ارتفاع في الدهون
+
+302
+00:25:37,260 --> 00:25:41,040
+الثلاثية بشكل هائل، بيكون عندهم التهاب في
+
+303
+00:25:41,040 --> 00:25:45,200
+البنكرياس. لأن الدهون الثلاثية بتترسب على الـ
+
+304
+00:25:45,200 --> 00:25:51,260
+pancreas. الـ hypertriglyceridemia، ارتفاع لـ
+
+305
+00:25:51,260 --> 00:25:56,700
+triglycerides في الدم، is associated، مربوط، with the
+
+306
+00:25:56,700 --> 00:26:01,160
+following clinical findings، مربوط بـ clinical
+
+307
+00:26:01,160 --> 00:26:06,460
+features، بيحكوا عنها بأعراض، تمام؟ يعني الناس اللي
+
+308
+00:26:06,460 --> 00:26:10,020
+بيكون عندهم ارتفاع في الدهون الثلاثية، بيكون عندهم
+
+309
+00:26:10,020 --> 00:26:15,650
+أعراض. مش شرط تنطبق عليهم كل الأعراض. أول شغلة الـ
+
+310
+00:26:15,650 --> 00:26:21,230
+eruptive xanthoma. الـ xanthoma يا جماعة زي
+
+311
+00:26:21,230 --> 00:26:26,590
+الرسمة اللي فوق، الأولى، هي عبارة عن تقرحات على سطح
+
+312
+00:26:26,590 --> 00:26:33,680
+ال skin، على سطح الجلد، أو بيحكوا عنها نتوءات، تقرحات
+
+313
+00:26:33,680 --> 00:26:38,980
+أو نتوءات على ال skin surface، على سطح الجلد، تظهر
+
+314
+00:26:38,980 --> 00:26:44,780
+في في في كل مناطق الجسم، تظهر في القدم، بالإيد، على
+
+315
+00:26:44,780 --> 00:26:50,250
+الرقبة، عالوجه. هذه التقرحات بتظهر في كل مكان. إيش
+
+316
+00:26:50,250 --> 00:26:54,190
+سببها؟ بتظهر نتيجة ارتفاع الدهون الثلاثية في
+
+317
+00:26:54,190 --> 00:26:58,270
+البلازما، بتبدأ الدهون الثلاثية تترسب على أعضاء
+
+318
+00:26:58,270 --> 00:27:02,030
+الجسم المختلفة، تترسب على الـ pancreas، بتبدأ تترسب
+
+319
+00:27:02,030 --> 00:27:07,350
+على الـ skin، تطلع على الـ skin، وبالتالي تعمل
+
+320
+00:27:07,350 --> 00:27:14,430
+تقرحات ونتوءات. Lipemia retinalis أيضًا، ارتفاع
+
+321
+00:27:14,430 --> 00:27:19,470
+الدهون الثلاثية في البلازما، بتخلي قرنية العين
+
+322
+00:27:19,470 --> 00:27:23,970
+لـ lipemia retinalis. معنى الكلام، لو شفت الصورة
+
+323
+00:27:23,970 --> 00:27:28,730
+التانية، شفت الشرايين والأوردة اللي بتغذي الشبكية
+
+324
+00:27:28,730 --> 00:27:32,720
+اللي بتغذي قرنية العين، المفروض يكون لونها أحمر، مش
+
+325
+00:27:32,720 --> 00:27:36,420
+بيمشي فيها الدم، ولكن نتيجة لارتفاع الدهون
+
+326
+00:27:36,420 --> 00:27:41,100
+الثلاثية في الـ plasma، بتبدأ الدهون الثلاثية تترسب
+
+327
+00:27:41,100 --> 00:27:46,900
+جوا الأوعية والشرايين، تمام؟ وطبعًا الدهون إيش بده
+
+328
+00:27:46,900 --> 00:27:51,640
+يكون لونها؟ زي الـ milky color، لون الحليب بالظبط.
+
+329
+00:27:52,560 --> 00:27:57,380
+بتبدو وكأنها milky appearance، زي الحليب زي ما احنا
+
+330
+00:27:57,380 --> 00:28:02,900
+شايفين، مش أوردة وشرايين حمراء، هذا نتيجة ترسب الدهون
+
+331
+00:28:02,900 --> 00:28:08,240
+الثلاثية في الأوردة والشرايين المغذية لقرنية العين.
+
+332
+00:28:08,240 --> 00:28:13,260
+هذه بنسميها lipemia retinalis. برضه من الأعراض ممكن
+
+333
+00:28:13,260 --> 00:28:17,860
+يصير عندنا hepatomegaly و splenomegaly، يعني تدخم في
+
+334
+00:28:17,860 --> 00:28:22,920
+ال liver وفي ال spleen. أيضًا، depressed الـ HDL،
+
+335
+00:28:22,920 --> 00:28:28,800
+ارتفاع الدهون الثلاثية بعمل depression، بعمل تثبيط
+
+336
+00:28:28,800 --> 00:28:36,320
+للـ HDL، أي بينقص من مستوى الـ HDL cholesterol. وهذا مش
+
+337
+00:28:36,320 --> 00:28:42,260
+كويس، وهنشوف لقدام لما ناخد الـ HDL ونفهم كويس إيش
+
+338
+00:28:42,260 --> 00:28:46,040
+دوره. إذا ارتفع الدهون الثلاثية، بيعمل depressed،
+
+339
+00:28:46,040 --> 00:28:51,760
+بيخفض من الـ HDL cholesterol. in characterizing risk
+
+340
+00:28:51,760 --> 00:28:56,340
+of cardiovascular disease. أكيد اللي عنده ارتفاع في
+
+341
+00:28:56,340 --> 00:29:00,160
+الدهون الثلاثية، بيكون عنده احتمال للإصابة بأمراض
+
+342
+00:29:00,160 --> 00:29:04,200
+القلب والأوعية الدموية. for the estimation of LDL
+
+343
+00:29:04,200 --> 00:29:08,640
+cholesterol using the Friedewald equation. إذا بدك
+
+344
+00:29:08,640 --> 00:29:12,540
+تحسب تركيز الـ LDL، بتستخدم معادلة هذه في نهاية
+
+345
+00:29:12,540 --> 00:29:14,220
+المحاضرة، هنفهمها.
+
+346
+00:29:16,450 --> 00:29:21,490
+خلونا يا جماعة نبدأ بالأهم. إيجاني شخص مكتوب في
+
+347
+00:29:21,490 --> 00:29:25,890
+الـ request تبعه، try a glyceride test، يعني فحص دهون
+
+348
+00:29:25,890 --> 00:29:30,690
+ثلاثية. إيش العينة اللي بدي أسحبها منه؟ العينة إما
+
+349
+00:29:30,690 --> 00:29:34,150
+serum أو بلازما. ولو بدي أسحب بلازما، نوع
+
+350
+00:29:34,150 --> 00:29:38,850
+الـ anticoagulant EDTA certain anticoagulants
+
+351
+00:29:38,850 --> 00:29:44,450
+لكن الـ anticoagulants الأخرى زي الفلورايد، الستريت،
+
+352
+00:29:44,450 --> 00:29:51,850
+الأوكزاليت، هذه ممنوعة بتاتا. لأن لو أنا جمعت عينة
+
+353
+00:29:51,850 --> 00:29:55,350
+الدم في هذه الـ anticoagulants، في الفلورايد أو
+
+354
+00:29:55,350 --> 00:30:02,600
+الستريت أو الأوكزاليت، إيش هيصير؟ هيؤدي ذلك إلى
+
+355
+00:30:02,600 --> 00:30:08,160
+cause large shifts of water from the red blood
+
+356
+00:30:08,160 --> 00:30:14,320
+cells to plasma. هتصير تطلع المية اللي موجودة جوة
+
+357
+00:30:14,320 --> 00:30:21,500
+الـ RBC، هتطلع بكميات كبيرة وتروح على بلازما الدم.
+
+358
+00:30:21,500 --> 00:30:26,260
+طبعًا في بلازما الدم عندنا سكر، وعندنا بروتينات، و
+
+359
+00:30:26,260 --> 00:30:30,080
+عندنا الـ lipids بأنواعها، ومواقع الـ lipids كلها
+
+360
+00:30:30,080 --> 00:30:33,740
+موجودة في البلازما. فلما المية يصير لها الـ shift،
+
+361
+00:30:33,740 --> 00:30:41,030
+تطلع من الـ RBCs وتروح ليه على البلازما؟ إيش هيصير
+
+362
+00:30:41,030 --> 00:30:45,710
+في مكونات البلازما؟ هتتخفف، وبالتالي الـ limits اللي
+
+363
+00:30:45,710 --> 00:30:50,290
+موجودة في البلازما، البروتينات، كل هذا هيتخفف ويجي
+
+364
+00:30:50,290 --> 00:30:55,150
+تركيزه بشكل خاطئ، which results in the dilution of
+
+365
+00:30:55,150 --> 00:30:59,590
+the plasma components. تقريبًا 10% من الدهون
+
+366
+00:30:59,590 --> 00:31:06,910
+الثلاثية هيتخفف. إذن ليش ممنوع أي anticoagulant، فقط
+
+367
+00:31:06,910 --> 00:31:10,110
+المسموح فيه الـ EDTA؟ لأنه لو استخدمت هذه الـ
+
+368
+00:31:10,110 --> 00:31:14,430
+anticoagulants، بتعمل shifting للـ water، بتطلع المية
+
+369
+00:31:14,430 --> 00:31:18,450
+الموجودة في خلايا الدم الحمراء، وبتخليها تروح على
+
+370
+00:31:18,450 --> 00:31:21,730
+البلازما. وبالتالي، هذه المية زيادتها في
+
+371
+00:31:21,730 --> 00:31:26,330
+البلازما، هتخفف الـ components، مكونات البلازما، بما
+
+372
+00:31:26,330 --> 00:31:30,550
+فيها الـ lipids، بما فيها الدهون الثلاثية، هيجي
+
+373
+00:31:30,550 --> 00:31:37,460
+تركيزها عن الطبيعي. لازم فحص الدهون الثلاثية تكون
+
+374
+00:31:37,460 --> 00:31:43,220
+صائم من 12 لـ 16 ساعة، لأن اتفقنا الدهون الثلاثية
+
+375
+00:31:43,220 --> 00:31:49,100
+مصادرها خارجية من الأكل، فإنت لو أكلت أكل، مش هعرف
+
+376
+00:31:49,100 --> 00:31:52,640
+أفحص لك فحص الدهون الثلاثية. هلأ جيت الدهون الثلاثية
+
+377
+00:31:52,640 --> 00:31:56,940
+مرتفع عندك، تمام؟ لأن أنت فعليًا بتكون ماكل أكلات
+
+378
+00:31:56,940 --> 00:32:02,590
+فيها دهون ثلاثية، فلازم نكون صائمين. Samples drawn
+
+379
+00:32:02,590 --> 00:32:05,810
+from non-fasting patients are not suitable for
+
+380
+00:32:05,810 --> 00:32:10,670
+analysis. أي عينة بتتاخد من مريض مش صائم، هذه العينة
+
+381
+00:32:10,670 --> 00:32:17,150
+مش مقبولة، ما بدنا اياها، مش مناسبة للفحص، لأنه بما أنه
+
+382
+00:32:17,150 --> 00:32:22,110
+non-fasting، زي ما حكيت لكم، مش صائم، يعني بياكل، والأكل
+
+383
+00:32:22,110 --> 00:32:25,870
+هيكون فيه دهون ثلاثية، وبالتالي لو فحصنا الدهون
+
+384
+00:32:25,870 --> 00:32:31,150
+الثلاثية، هتكون عالية كتير. طب هل عالية كتير لأنه
+
+385
+00:32:31,150 --> 00:32:35,930
+ماكل أكلات فيها دهون ثلاثية، ولا عالية كتير لأنه
+
+386
+00:32:35,930 --> 00:32:40,830
+عنده مشاكل أصلا في الدهون الثلاثية في الجسم؟ مش
+
+387
+00:32:40,830 --> 00:32:46,370
+هقدر أميز. since elevated triglyceride levels
+
+388
+00:32:47,690 --> 00:32:52,310
+caused by normal absorption of food. ارتفاع
+
+389
+00:32:52,310 --> 00:32:57,770
+عالية هيكون بسبب الأكل، cannot be distinguished، مش
+
+390
+00:32:57,770 --> 00:33:04,430
+هقدر أميزه عن الارتفاع اللي بيكون سببه أصلا حالة
+
+391
+00:33:04,430 --> 00:33:08,390
+مرضية، lipid metabolism or inborn error of
+
+392
+00:33:08,390 --> 00:33:12,950
+metabolism. تمام؟ عشان هيك لازم نكون صائمين. تخزين
+
+393
+00:33:12,950 --> 00:33:16,330
+ال serum والبلازما في ال room temperature مدة
+
+394
+00:33:16,330 -->
\ No newline at end of file
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/_KHiyilTHZ0_raw.json b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/_KHiyilTHZ0_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..fac829219a040f9106755f4bbc93fb31c90f412c
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/_KHiyilTHZ0_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 1045, "start": 0.81, "end": 10.45, "text": "السلام عليكم ورحمة الله وبركاته يعطيكم العافية جميعا ان شاء الله اليوم موضوعنا lipid profiling فحوصات الدهون", "tokens": [6027, 3794, 37440, 25894, 24793, 4032, 2288, 35571, 3660, 21984, 4032, 26890, 4117, 9307, 3224, 37495, 9566, 1829, 24793, 18863, 31845, 10632, 10874, 2304, 40228, 995, 16472, 13412, 16606, 21984, 45595, 20498, 3714, 2407, 11242, 45367, 8315, 8280, 327, 1740, 4883, 6156, 5016, 2407, 9381, 9307, 32748, 3224, 11536], "avg_logprob": -0.14054687917232514, "compression_ratio": 1.3880597014925373, "no_speech_prob": 3.5762786865234375e-07, "words": [{"start": 0.81, "end": 1.19, "word": "السلام", "probability": 0.83447265625}, {"start": 1.19, "end": 1.59, "word": " عليكم", "probability": 0.94140625}, {"start": 1.59, "end": 2.01, "word": " ورحمة", "probability": 0.886962890625}, {"start": 2.01, "end": 2.27, "word": " الله", "probability": 0.97509765625}, {"start": 2.27, "end": 3.13, "word": " 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0.59033203125}, {"start": 101.23, "end": 102.41, "word": " pathogenesis", "probability": 0.9705403645833334}, {"start": 102.41, "end": 102.75, "word": " of", "probability": 0.9755859375}, {"start": 102.75, "end": 104.41, "word": " atherosclerosis", "probability": 0.86923828125}, {"start": 104.41, "end": 105.41, "word": " بيحكيلي", "probability": 0.8902994791666666}, {"start": 105.41, "end": 106.25, "word": " ارتفاع", "probability": 0.979736328125}, {"start": 106.25, "end": 107.09, "word": " مستوى", "probability": 0.97412109375}, {"start": 107.09, "end": 107.85, "word": " الدهون", "probability": 0.9869791666666666}], "temperature": 1.0}, {"id": 6, "seek": 12827, "start": 108.05, "end": 128.27, "text": "وتركيز الدهون في البلازمة لما بتزيد وبالأخص الكوليسترول هذا مرتبط ارتباط وثيق بحدوث تصلب الشرايين إذا تصلب الشرايين ثبت من أسبابه هو ارتفاع الدهون في بلازمة الدم", "tokens": [35473, 31747, 1829, 11622, 32748, 3224, 11536, 8978, 29739, 1211, 31377, 46007, 5296, 15042, 39894, 11622, 25708, 46599, 6027, 10721, 9778, 9381, 33251, 12610, 1829, 14851, 2288, 12610, 23758, 3714, 43500, 3555, 9566, 1975, 43500, 3555, 41193, 4032, 12984, 1829, 4587, 4724, 24401, 2407, 12984, 6055, 9381, 46152, 25124, 23557, 1829, 9957, 11933, 15730, 6055, 9381, 46152, 25124, 23557, 1829, 9957, 38637, 3555, 2655, 9154, 5551, 35457, 16758, 3224, 31439, 1975, 43500, 5172, 45761, 32748, 3224, 11536, 8978, 4724, 1211, 31377, 46007, 32748, 2304], "avg_logprob": -0.15165440755731918, "compression_ratio": 1.8734177215189873, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 108.05, "end": 109.11, "word": "وتركيز", "probability": 0.962158203125}, {"start": 109.11, "end": 109.65, "word": " الدهون", "probability": 0.9461263020833334}, {"start": 109.65, "end": 109.95, "word": " في", "probability": 0.94189453125}, {"start": 109.95, "end": 110.71, "word": " البلازمة", "probability": 0.646240234375}, {"start": 110.71, "end": 111.39, "word": " لما", "probability": 0.833740234375}, {"start": 111.39, "end": 112.05, "word": " بتزيد", "probability": 0.8898111979166666}, {"start": 112.05, "end": 113.53, "word": " وبالأخص", "probability": 0.83056640625}, {"start": 113.53, "end": 114.51, "word": " الكوليسترول", "probability": 0.8860677083333334}, {"start": 114.51, "end": 115.09, "word": " هذا", "probability": 0.59326171875}, {"start": 115.09, "end": 116.01, "word": " مرتبط", "probability": 0.9857177734375}, {"start": 116.01, "end": 116.71, "word": " ارتباط", "probability": 0.9693603515625}, {"start": 116.71, "end": 117.43, "word": " وثيق", "probability": 0.884521484375}, {"start": 117.43, "end": 118.83, "word": " بحدوث", "probability": 0.95556640625}, {"start": 118.83, "end": 119.69, "word": " تصلب", "probability": 0.8047688802083334}, {"start": 119.69, "end": 120.61, "word": " الشرايين", "probability": 0.836669921875}, {"start": 120.61, "end": 121.07, "word": " إذا", "probability": 0.5030517578125}, {"start": 121.07, "end": 121.71, "word": " تصلب", "probability": 0.8981119791666666}, {"start": 121.71, "end": 122.45, "word": " الشرايين", "probability": 0.9437255859375}, {"start": 122.45, "end": 123.07, "word": " ثبت", "probability": 0.7738444010416666}, {"start": 123.07, "end": 123.31, "word": " من", "probability": 0.9833984375}, {"start": 123.31, "end": 124.05, "word": " أسبابه", "probability": 0.9774169921875}, {"start": 124.05, "end": 124.55, "word": " هو", "probability": 0.94287109375}, {"start": 124.55, "end": 125.73, "word": " ارتفاع", "probability": 0.9776611328125}, {"start": 125.73, "end": 126.41, "word": " الدهون", "probability": 0.9899088541666666}, {"start": 126.41, "end": 126.85, "word": " في", "probability": 0.96484375}, {"start": 126.85, "end": 127.71, "word": " بلازمة", "probability": 0.852783203125}, {"start": 127.71, "end": 128.27, "word": " الدم", "probability": 0.98486328125}], "temperature": 1.0}, {"id": 7, "seek": 14732, "start": 130.54, "end": 147.32, "text": "Lipids transport نقل الدهون في البلازمة Lipids are carried in the bloodstream by complexes known as lipoproteins بدنا نعرف هال gate لو الإنسان اتناول أكل مليان دهون", "tokens": [43, 647, 3742, 5495, 8717, 4587, 1211, 32748, 3224, 11536, 8978, 29739, 1211, 31377, 46007, 27475, 3742, 366, 9094, 294, 264, 3390, 9291, 538, 43676, 2570, 382, 8280, 404, 81, 1370, 1292, 47525, 8315, 8717, 3615, 28480, 8032, 6027, 8539, 45164, 33688, 1863, 3794, 7649, 1975, 2655, 8315, 12610, 5551, 28820, 3714, 20292, 7649, 11778, 3224, 11536], "avg_logprob": -0.20959052315046048, "compression_ratio": 1.277456647398844, "no_speech_prob": 0.0, "words": [{"start": 130.54, "end": 131.18, "word": "Lipids", "probability": 0.7845052083333334}, {"start": 131.18, "end": 132.16, "word": " transport", "probability": 0.517578125}, {"start": 132.16, "end": 133.2, "word": " نقل", "probability": 0.89599609375}, {"start": 133.2, "end": 134.1, "word": " الدهون", "probability": 0.9778645833333334}, {"start": 134.1, "end": 134.52, "word": " في", "probability": 0.89404296875}, {"start": 134.52, "end": 135.48, "word": " البلازمة", "probability": 0.74798583984375}, {"start": 135.48, "end": 136.38, "word": " Lipids", "probability": 0.6304931640625}, {"start": 136.38, "end": 136.7, "word": " are", "probability": 0.94091796875}, {"start": 136.7, "end": 137.14, "word": " carried", "probability": 0.93017578125}, {"start": 137.14, "end": 137.5, "word": " in", "probability": 0.96337890625}, {"start": 137.5, "end": 137.66, "word": " the", "probability": 0.88720703125}, {"start": 137.66, "end": 138.46, "word": " bloodstream", "probability": 0.737060546875}, {"start": 138.46, "end": 138.96, "word": " by", "probability": 0.8984375}, {"start": 138.96, "end": 139.74, "word": " complexes", "probability": 0.79345703125}, {"start": 139.74, "end": 140.24, "word": " known", "probability": 0.6728515625}, {"start": 140.24, "end": 140.82, "word": " as", "probability": 0.9775390625}, {"start": 140.82, "end": 142.52, "word": " lipoproteins", "probability": 0.76611328125}, {"start": 142.52, "end": 143.12, "word": " بدنا", "probability": 0.71484375}, {"start": 143.12, "end": 143.44, "word": " نعرف", "probability": 0.99560546875}, {"start": 143.44, "end": 143.64, "word": " هال", "probability": 0.6180419921875}, {"start": 143.64, "end": 144.0, "word": " gate", "probability": 0.2783203125}, {"start": 144.0, "end": 144.38, "word": " لو", "probability": 0.97021484375}, {"start": 144.38, "end": 144.98, "word": " الإنسان", "probability": 0.9794921875}, {"start": 144.98, "end": 145.4, "word": " اتناول", "probability": 0.8570556640625}, {"start": 145.4, "end": 145.88, "word": " أكل", "probability": 0.85791015625}, {"start": 145.88, "end": 146.68, "word": " مليان", "probability": 0.9949544270833334}, {"start": 146.68, "end": 147.32, "word": " دهون", "probability": 0.9793294270833334}], "temperature": 1.0}, {"id": 8, "seek": 17075, "start": 147.79, "end": 170.75, "text": "أو الجسم صنع هذه الدهون في الآخر الدهون هتكون موجودة في الـ blood stream في الدم في الـ plasma هلجت هذه الدهون لو بدها تنتقل من الدم إلى أنسجة الجسم إلى خلايا الجسم عشان الخلايا أحيانا تحتاج إلى دهون عشان تشتغل أو عشان تتكون", "tokens": [10721, 2407, 25724, 38251, 20328, 1863, 3615, 29538, 32748, 3224, 11536, 8978, 6024, 95, 34740, 32748, 3224, 11536, 8032, 2655, 30544, 3714, 29245, 23328, 3660, 8978, 2423, 39184, 3390, 4309, 8978, 32748, 2304, 8978, 2423, 39184, 22564, 8032, 1211, 7435, 2655, 29538, 32748, 3224, 11536, 45164, 47525, 11296, 6055, 29399, 4587, 1211, 9154, 32748, 2304, 30731, 14739, 3794, 7435, 3660, 25724, 38251, 30731, 16490, 15040, 25528, 25724, 38251, 6225, 8592, 7649, 33962, 15040, 25528, 5551, 5016, 1829, 7649, 995, 6055, 33753, 26108, 30731, 11778, 3224, 11536, 6225, 8592, 7649, 6055, 8592, 2655, 17082, 1211, 34051, 6225, 8592, 7649, 6055, 2655, 30544], "avg_logprob": -0.11236213344861479, "compression_ratio": 1.9897435897435898, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 147.79, "end": 148.43, "word": "أو", "probability": 0.92724609375}, {"start": 148.43, "end": 149.67, "word": " الجسم", "probability": 0.937744140625}, {"start": 149.67, "end": 150.23, "word": " صنع", "probability": 0.9147135416666666}, {"start": 150.23, "end": 150.69, "word": " هذه", "probability": 0.91015625}, {"start": 150.69, "end": 151.39, "word": " الدهون", "probability": 0.9703776041666666}, {"start": 151.39, "end": 151.83, "word": " في", "probability": 0.56787109375}, {"start": 151.83, "end": 152.27, "word": " الآخر", "probability": 0.8878580729166666}, {"start": 152.27, "end": 152.77, "word": " الدهون", "probability": 0.97314453125}, {"start": 152.77, "end": 153.29, "word": " هتكون", "probability": 0.86572265625}, {"start": 153.29, "end": 153.95, "word": " موجودة", "probability": 0.9827880859375}, {"start": 153.95, "end": 154.17, "word": " في", "probability": 0.96044921875}, {"start": 154.17, "end": 154.57, "word": " الـ", "probability": 0.65478515625}, {"start": 154.57, "end": 154.85, "word": " blood", "probability": 0.37841796875}, {"start": 154.85, "end": 155.59, "word": " stream", "probability": 0.6572265625}, {"start": 155.59, "end": 155.85, "word": " في", "probability": 0.74365234375}, {"start": 155.85, "end": 156.27, "word": " الدم", "probability": 0.9755859375}, {"start": 156.27, "end": 156.51, "word": " في", "probability": 0.5068359375}, {"start": 156.51, "end": 156.85, "word": " الـ", "probability": 0.584716796875}, {"start": 156.85, "end": 157.13, "word": " plasma", "probability": 0.625}, {"start": 157.13, "end": 158.15, "word": " هلجت", "probability": 0.68170166015625}, {"start": 158.15, "end": 158.49, "word": " هذه", "probability": 0.97607421875}, {"start": 158.49, "end": 159.11, "word": " الدهون", "probability": 0.9908854166666666}, {"start": 159.11, "end": 159.69, "word": " لو", "probability": 0.98779296875}, {"start": 159.69, "end": 160.07, "word": " بدها", "probability": 0.968017578125}, {"start": 160.07, "end": 160.81, "word": " تنتقل", "probability": 0.9857177734375}, {"start": 160.81, "end": 161.15, "word": " من", "probability": 0.9970703125}, {"start": 161.15, "end": 161.59, "word": " الدم", "probability": 0.986328125}, {"start": 161.59, "end": 162.19, "word": " إلى", "probability": 0.9443359375}, {"start": 162.19, "end": 163.03, "word": " أنسجة", "probability": 0.9573974609375}, {"start": 163.03, "end": 163.47, "word": " الجسم", "probability": 0.988037109375}, {"start": 163.47, "end": 163.81, "word": " إلى", "probability": 0.95556640625}, {"start": 163.81, "end": 164.39, "word": " خلايا", "probability": 0.9801432291666666}, {"start": 164.39, "end": 164.87, "word": " الجسم", "probability": 0.99169921875}, {"start": 164.87, "end": 165.31, "word": " عشان", "probability": 0.97119140625}, {"start": 165.31, "end": 165.95, "word": " الخلايا", "probability": 0.9739583333333334}, {"start": 165.95, "end": 166.83, "word": " أحيانا", "probability": 0.97529296875}, {"start": 166.83, "end": 167.55, "word": " تحتاج", "probability": 0.7910970052083334}, {"start": 167.55, "end": 167.91, "word": " إلى", "probability": 0.953125}, {"start": 167.91, "end": 168.39, "word": " دهون", "probability": 0.9842122395833334}, {"start": 168.39, "end": 168.95, "word": " عشان", "probability": 0.9925130208333334}, {"start": 168.95, "end": 169.53, "word": " تشتغل", "probability": 0.99677734375}, {"start": 169.53, "end": 169.87, "word": " أو", "probability": 0.92431640625}, {"start": 169.87, "end": 170.19, "word": " عشان", "probability": 0.99462890625}, {"start": 170.19, "end": 170.75, "word": " تتكون", "probability": 0.9427083333333334}], "temperature": 1.0}, {"id": 9, "seek": 19754, "start": 171.3, "end": 197.54, "text": "وبالتالي الدهون Insoluble in بلازمة غير دائبة في بلازمة الدم وبالتالي ماتتقدر الدهون تتحرك بشكل free في البلازمة ماتتقدر تمشي لحالها وبالتالي تحتاج إلى Transporter إلى مواقل تنجلها من مكان لمكان مواقل الدهون سموها لايبو بروتين", "tokens": [37746, 6027, 2655, 6027, 1829, 32748, 3224, 11536, 9442, 39754, 638, 294, 4724, 1211, 31377, 46007, 32771, 13546, 11778, 16373, 49401, 8978, 4724, 1211, 31377, 46007, 32748, 2304, 46599, 6027, 2655, 6027, 1829, 3714, 9307, 2655, 28543, 2288, 32748, 3224, 11536, 6055, 2655, 5016, 31747, 4724, 8592, 28820, 1737, 8978, 29739, 1211, 31377, 46007, 3714, 9307, 2655, 28543, 2288, 46811, 8592, 1829, 5296, 5016, 6027, 11296, 46599, 6027, 2655, 6027, 1829, 6055, 33753, 26108, 30731, 6531, 37356, 30731, 3714, 14407, 4587, 1211, 6055, 1863, 7435, 1211, 11296, 9154, 3714, 41361, 32767, 41361, 3714, 14407, 4587, 1211, 32748, 3224, 11536, 8608, 2304, 2407, 11296, 5296, 47302, 3555, 2407, 4724, 32887, 2655, 9957], "avg_logprob": -0.1480189717507788, "compression_ratio": 1.8980582524271845, "no_speech_prob": 0.0, "words": [{"start": 171.3, "end": 172.16, "word": "وبالتالي", "probability": 0.95615234375}, {"start": 172.16, "end": 173.0, "word": " الدهون", "probability": 0.943359375}, {"start": 173.0, "end": 174.44, "word": " Insoluble", "probability": 0.6484781901041666}, {"start": 174.44, "end": 174.82, "word": " in", "probability": 0.81005859375}, {"start": 174.82, "end": 175.42, "word": " بلازمة", "probability": 0.586669921875}, {"start": 175.42, "end": 176.1, "word": " غير", "probability": 0.93408203125}, {"start": 176.1, "end": 176.7, "word": " دائبة", "probability": 0.9430338541666666}, {"start": 176.7, "end": 177.14, "word": " في", "probability": 0.96630859375}, {"start": 177.14, "end": 177.82, "word": " بلازمة", "probability": 0.878662109375}, {"start": 177.82, "end": 178.16, "word": " الدم", "probability": 0.983642578125}, {"start": 178.16, "end": 179.1, "word": " وبالتالي", "probability": 0.95107421875}, {"start": 179.1, "end": 180.02, "word": " ماتتقدر", "probability": 0.757080078125}, {"start": 180.02, "end": 180.74, "word": " الدهون", "probability": 0.9835611979166666}, {"start": 180.74, "end": 181.9, "word": " تتحرك", "probability": 0.989990234375}, {"start": 181.9, "end": 182.68, "word": " بشكل", "probability": 0.990234375}, {"start": 182.68, "end": 183.14, "word": " free", "probability": 0.485595703125}, {"start": 183.14, "end": 183.32, "word": " في", "probability": 0.84765625}, {"start": 183.32, "end": 183.86, "word": " البلازمة", "probability": 0.9051513671875}, {"start": 183.86, "end": 184.78, "word": " ماتتقدر", "probability": 0.9359375}, {"start": 184.78, "end": 185.22, "word": " تمشي", "probability": 0.9713541666666666}, {"start": 185.22, "end": 186.08, "word": " لحالها", "probability": 0.9884033203125}, {"start": 186.08, "end": 187.36, "word": " وبالتالي", "probability": 0.959765625}, {"start": 187.36, "end": 188.1, "word": " تحتاج", "probability": 0.98828125}, {"start": 188.1, "end": 188.38, "word": " إلى", "probability": 0.87060546875}, {"start": 188.38, "end": 189.5, "word": " Transporter", "probability": 0.763427734375}, {"start": 189.5, "end": 190.04, "word": " إلى", "probability": 0.7724609375}, {"start": 190.04, "end": 190.72, "word": " مواقل", "probability": 0.9442138671875}, {"start": 190.72, "end": 191.48, "word": " تنجلها", "probability": 0.97998046875}, {"start": 191.48, "end": 191.78, "word": " من", "probability": 0.99267578125}, {"start": 191.78, "end": 192.3, "word": " مكان", "probability": 0.993408203125}, {"start": 192.3, "end": 192.98, "word": " لمكان", "probability": 0.927490234375}, {"start": 192.98, "end": 194.2, "word": " مواقل", "probability": 0.9764404296875}, {"start": 194.2, "end": 194.8, "word": " الدهون", "probability": 0.9874674479166666}, {"start": 194.8, "end": 195.72, "word": " سموها", "probability": 0.93798828125}, {"start": 195.72, "end": 196.72, "word": " لايبو", "probability": 0.6215972900390625}, {"start": 196.72, "end": 197.54, "word": " بروتين", "probability": 0.81085205078125}], "temperature": 1.0}, {"id": 10, "seek": 20925, "start": 198.23, "end": 209.25, "text": "هي بالاصل المواقع عبارة عن البروتينات فسموها الـLiboproteins يعني بروتينات تنقل الليبد كلمة لايبو من الليبد", "tokens": [3224, 1829, 20666, 33546, 1211, 9673, 14407, 4587, 3615, 6225, 3555, 9640, 3660, 18871, 2423, 26890, 35473, 9957, 9307, 6156, 38251, 2407, 11296, 2423, 39184, 43, 897, 404, 81, 1370, 1292, 37495, 22653, 4724, 32887, 2655, 9957, 9307, 6055, 1863, 4587, 1211, 13672, 1829, 44510, 9122, 19528, 3660, 5296, 47302, 3555, 2407, 9154, 13672, 1829, 44510], "avg_logprob": -0.24465460526315788, "compression_ratio": 1.4841269841269842, "no_speech_prob": 0.0, "words": [{"start": 198.23, "end": 198.57, "word": "هي", "probability": 0.845703125}, {"start": 198.57, "end": 199.17, "word": " بالاصل", "probability": 0.9259440104166666}, {"start": 199.17, "end": 199.93, "word": " المواقع", "probability": 0.8406982421875}, {"start": 199.93, "end": 200.53, "word": " عبارة", "probability": 0.9925537109375}, {"start": 200.53, "end": 200.71, "word": " عن", "probability": 0.9951171875}, {"start": 200.71, "end": 201.63, "word": " البروتينات", "probability": 0.740380859375}, {"start": 201.63, "end": 202.55, "word": " فسموها", "probability": 0.9476318359375}, {"start": 202.55, "end": 204.11, "word": " الـLiboproteins", "probability": 0.665283203125}, {"start": 204.11, "end": 204.59, "word": " يعني", "probability": 0.945556640625}, {"start": 204.59, "end": 205.39, "word": " بروتينات", "probability": 0.8650390625}, {"start": 205.39, "end": 206.13, "word": " تنقل", "probability": 0.9913330078125}, {"start": 206.13, "end": 206.61, "word": " الليبد", "probability": 0.5276692708333334}, {"start": 206.61, "end": 207.43, "word": " كلمة", "probability": 0.9405924479166666}, {"start": 207.43, "end": 208.19, "word": " لايبو", "probability": 0.705474853515625}, {"start": 208.19, "end": 208.59, "word": " من", "probability": 0.97607421875}, {"start": 208.59, "end": 209.25, "word": " الليبد", "probability": 0.8260091145833334}], "temperature": 1.0}, {"id": 11, "seek": 22872, "start": 210.14, "end": 228.72, "text": "إذاً لبدز are carried in the bloodstream by complexes known as lipoprotein الدهون تنقل في الدم من خلال البروتينات سمنها هذه البروتينات عبارة عن نواقل سمنها الـ lipoproteins نواقل الدهون", "tokens": [28814, 15730, 14111, 5296, 3555, 3215, 11622, 366, 9094, 294, 264, 3390, 9291, 538, 43676, 2570, 382, 8280, 404, 81, 1370, 259, 32748, 3224, 11536, 6055, 1863, 4587, 1211, 8978, 32748, 2304, 9154, 16490, 1211, 6027, 2423, 26890, 35473, 9957, 9307, 8608, 27842, 11296, 29538, 2423, 26890, 35473, 9957, 9307, 6225, 3555, 9640, 3660, 18871, 8717, 14407, 4587, 1211, 8608, 27842, 11296, 2423, 39184, 8280, 404, 81, 1370, 1292, 8717, 14407, 4587, 1211, 32748, 3224, 11536], "avg_logprob": -0.23356331788100204, "compression_ratio": 1.5568181818181819, "no_speech_prob": 0.0, "words": [{"start": 210.14, "end": 210.92, "word": "إذاً", "probability": 0.5801595052083334}, {"start": 210.92, "end": 211.42, "word": " لبدز", "probability": 0.50640869140625}, {"start": 211.42, "end": 211.64, "word": " are", "probability": 0.1337890625}, {"start": 211.64, "end": 212.0, "word": " carried", "probability": 0.9130859375}, {"start": 212.0, "end": 212.26, "word": " in", "probability": 0.951171875}, {"start": 212.26, "end": 212.38, "word": " the", "probability": 0.70703125}, {"start": 212.38, "end": 213.12, "word": " bloodstream", "probability": 0.7861328125}, {"start": 213.12, "end": 213.6, "word": " by", "probability": 0.638671875}, {"start": 213.6, "end": 214.4, "word": " complexes", "probability": 0.703125}, {"start": 214.4, "end": 215.06, "word": " known", "probability": 0.5810546875}, {"start": 215.06, "end": 215.66, "word": " as", "probability": 0.98046875}, {"start": 215.66, "end": 216.52, "word": " lipoprotein", "probability": 0.778515625}, {"start": 216.52, "end": 217.26, "word": " الدهون", "probability": 0.9342447916666666}, {"start": 217.26, "end": 218.2, "word": " تنقل", "probability": 0.9356689453125}, {"start": 218.2, "end": 218.54, "word": " في", "probability": 0.9658203125}, {"start": 218.54, "end": 219.02, "word": " الدم", "probability": 0.989990234375}, {"start": 219.02, "end": 219.54, "word": " من", "probability": 0.99853515625}, {"start": 219.54, "end": 220.26, "word": " خلال", "probability": 0.9964192708333334}, {"start": 220.26, "end": 221.3, "word": " البروتينات", "probability": 0.91474609375}, {"start": 221.3, "end": 222.32, "word": " سمنها", "probability": 0.7130533854166666}, {"start": 222.32, "end": 222.92, "word": " هذه", "probability": 0.40966796875}, {"start": 222.92, "end": 223.54, "word": " البروتينات", "probability": 0.9638671875}, {"start": 223.54, "end": 224.02, "word": " عبارة", "probability": 0.895263671875}, {"start": 224.02, "end": 224.22, "word": " عن", "probability": 0.9970703125}, {"start": 224.22, "end": 224.84, "word": " نواقل", "probability": 0.931396484375}, {"start": 224.84, "end": 225.66, "word": " سمنها", "probability": 0.9392903645833334}, {"start": 225.66, "end": 226.18, "word": " الـ", "probability": 0.474609375}, {"start": 226.18, "end": 227.1, "word": " lipoproteins", "probability": 0.8462890625}, {"start": 227.1, "end": 228.2, "word": " نواقل", "probability": 0.870361328125}, {"start": 228.2, "end": 228.72, "word": " الدهون", "probability": 0.9903971354166666}], "temperature": 1.0}, {"id": 12, "seek": 24546, "start": 228.96, "end": 245.46, "text": "This is because these lipids are not soluble in the plasma water ليش؟ أنا بدي نواقل للدهون لإن الدهون بطبيعتها لا تذوب في بلازمة الدم ما تقدر تمشي في البلازمة بشكل إفري", "tokens": [5723, 307, 570, 613, 8280, 3742, 366, 406, 24807, 638, 294, 264, 22564, 1281, 32239, 8592, 22807, 41850, 4724, 16254, 8717, 14407, 4587, 1211, 24976, 3215, 3224, 11536, 5296, 28814, 1863, 32748, 3224, 11536, 4724, 9566, 21292, 34268, 11296, 20193, 6055, 8848, 37746, 8978, 4724, 1211, 31377, 46007, 32748, 2304, 19446, 6055, 28543, 2288, 46811, 8592, 1829, 8978, 29739, 1211, 31377, 46007, 4724, 8592, 28820, 11933, 5172, 16572], "avg_logprob": -0.21444746635962222, "compression_ratio": 1.4078212290502794, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 228.96, "end": 229.36, "word": "This", "probability": 0.10162353515625}, {"start": 229.36, "end": 229.54, "word": " is", "probability": 0.95166015625}, {"start": 229.54, "end": 230.08, "word": " because", "probability": 0.9443359375}, {"start": 230.08, "end": 230.52, "word": " these", "probability": 0.5654296875}, {"start": 230.52, "end": 231.12, "word": " lipids", "probability": 0.6402587890625}, {"start": 231.12, "end": 231.48, "word": " are", "probability": 0.85302734375}, {"start": 231.48, "end": 231.74, "word": " not", "probability": 0.95556640625}, {"start": 231.74, "end": 232.32, "word": " soluble", "probability": 0.9072265625}, {"start": 232.32, "end": 232.62, "word": " in", "probability": 0.94189453125}, {"start": 232.62, "end": 232.74, "word": " the", "probability": 0.63818359375}, {"start": 232.74, "end": 233.1, "word": " plasma", "probability": 0.97802734375}, {"start": 233.1, "end": 233.62, "word": " water", "probability": 0.94873046875}, {"start": 233.62, "end": 234.26, "word": " ليش؟", "probability": 0.650390625}, {"start": 234.26, "end": 234.4, "word": " أنا", "probability": 0.76123046875}, {"start": 234.4, "end": 235.26, "word": " بدي", "probability": 0.85107421875}, {"start": 235.26, "end": 236.34, "word": " نواقل", "probability": 0.9564208984375}, {"start": 236.34, "end": 236.98, "word": " للدهون", "probability": 0.9110107421875}, {"start": 236.98, "end": 237.56, "word": " لإن", "probability": 0.779052734375}, {"start": 237.56, "end": 238.08, "word": " الدهون", "probability": 0.9869791666666666}, {"start": 238.08, "end": 238.96, "word": " بطبيعتها", "probability": 0.9666015625}, {"start": 238.96, "end": 239.36, "word": " لا", "probability": 0.70458984375}, {"start": 239.36, "end": 240.04, "word": " تذوب", "probability": 0.9054361979166666}, {"start": 240.04, "end": 240.42, "word": " في", "probability": 0.935546875}, {"start": 240.42, "end": 241.28, "word": " بلازمة", "probability": 0.7081298828125}, {"start": 241.28, "end": 241.76, "word": " الدم", "probability": 0.981689453125}, {"start": 241.76, "end": 242.06, "word": " ما", "probability": 0.298095703125}, {"start": 242.06, "end": 242.72, "word": " تقدر", "probability": 0.8756510416666666}, {"start": 242.72, "end": 243.16, "word": " تمشي", "probability": 0.98681640625}, {"start": 243.16, "end": 243.28, "word": " في", "probability": 0.8623046875}, {"start": 243.28, "end": 244.02, "word": " البلازمة", "probability": 0.8741455078125}, {"start": 244.02, "end": 244.88, "word": " بشكل", "probability": 0.9930013020833334}, {"start": 244.88, "end": 245.46, "word": " إفري", "probability": 0.82568359375}], "temperature": 1.0}, {"id": 13, "seek": 27395, "start": 246.34, "end": 273.96, "text": "This they travel in micelle-like complexes composed of phospholipid, cholesterol and protein on the outside with cholesterol easter and triglyceride on the inside هلجيت بيشرحلي شكل النواقل؟ النواقل التفاجنة هي بروتينات تنقل الدهون فسموها الـLiboprotein بروتينات تنقل الليبو تنقل الليبد", "tokens": [5723, 436, 3147, 294, 22257, 2447, 12, 4092, 43676, 18204, 295, 19775, 401, 647, 327, 11, 24716, 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"word": " micelle", "probability": 0.29400634765625}, {"start": 248.94, "end": 249.5, "word": "-like", "probability": 0.896240234375}, {"start": 249.5, "end": 250.4, "word": " complexes", "probability": 0.91064453125}, {"start": 250.4, "end": 251.16, "word": " composed", "probability": 0.75048828125}, {"start": 251.16, "end": 251.58, "word": " of", "probability": 0.97802734375}, {"start": 251.58, "end": 252.5, "word": " phospholipid,", "probability": 0.761749267578125}, {"start": 252.76, "end": 253.22, "word": " cholesterol", "probability": 0.626953125}, {"start": 253.22, "end": 253.9, "word": " and", "probability": 0.70166015625}, {"start": 253.9, "end": 254.46, "word": " protein", "probability": 0.84326171875}, {"start": 254.46, "end": 254.88, "word": " on", "probability": 0.56103515625}, {"start": 254.88, "end": 255.22, "word": " the", "probability": 0.94482421875}, {"start": 255.22, "end": 255.82, "word": " outside", "probability": 0.85888671875}, {"start": 255.82, "end": 256.56, "word": " with", "probability": 0.849609375}, {"start": 256.56, "end": 257.24, "word": " cholesterol", "probability": 0.80419921875}, {"start": 257.24, "end": 258.0, "word": " easter", "probability": 0.3944091796875}, {"start": 258.0, "end": 258.56, "word": " and", "probability": 0.92138671875}, {"start": 258.56, "end": 259.74, "word": " triglyceride", "probability": 0.8948974609375}, {"start": 259.74, "end": 260.3, "word": " on", "probability": 0.9404296875}, {"start": 260.3, "end": 260.82, "word": " the", "probability": 0.92919921875}, {"start": 260.82, "end": 261.5, "word": " inside", "probability": 0.95703125}, {"start": 261.5, "end": 262.16, "word": " هلجيت", "probability": 0.743408203125}, {"start": 262.16, "end": 262.92, "word": " بيشرحلي", "probability": 0.89609375}, {"start": 262.92, "end": 263.64, "word": " شكل", "probability": 0.986572265625}, {"start": 263.64, "end": 265.2, "word": " النواقل؟", "probability": 0.80107421875}, {"start": 265.2, "end": 265.76, "word": " النواقل", "probability": 0.9669189453125}, {"start": 265.76, "end": 266.3, "word": " التفاجنة", "probability": 0.778125}, {"start": 266.3, "end": 266.48, "word": " هي", "probability": 0.73876953125}, {"start": 266.48, "end": 267.44, "word": " بروتينات", "probability": 0.80302734375}, {"start": 267.44, "end": 268.28, "word": " تنقل", "probability": 0.968017578125}, {"start": 268.28, "end": 268.86, "word": " الدهون", "probability": 0.9728190104166666}, {"start": 268.86, "end": 269.76, "word": " فسموها", "probability": 0.9420166015625}, {"start": 269.76, "end": 271.14, "word": " الـLiboprotein", "probability": 0.668487548828125}, {"start": 271.14, "end": 271.84, "word": " بروتينات", "probability": 0.95}, {"start": 271.84, "end": 272.38, "word": " تنقل", "probability": 0.9970703125}, {"start": 272.38, "end": 273.06, "word": " الليبو", "probability": 0.8397216796875}, {"start": 273.06, "end": 273.58, "word": " تنقل", "probability": 0.9117431640625}, {"start": 273.58, "end": 273.96, "word": " الليبد", "probability": 0.7593994140625}], "temperature": 1.0}, {"id": 14, "seek": 28708, "start": 274.42, "end": 287.08, "text": "هذه اللايبو بروتين هذه النواقل عادةً شكلها مثل شكل الميسل بدنا نتخيلها، إيش يعني الميسل؟ مثل شكل الكرة، تمام؟ هيك مكورة، من برا", "tokens": [3224, 24192, 13672, 47302, 3555, 2407, 4724, 32887, 31371, 1863, 29538, 28239, 14407, 4587, 1211, 6225, 18513, 3660, 14111, 13412, 28820, 11296, 50113, 1211, 13412, 28820, 9673, 1829, 3794, 1211, 47525, 8315, 8717, 2655, 9778, 26895, 11296, 12399, 11933, 1829, 8592, 37495, 22653, 9673, 1829, 3794, 1211, 22807, 50113, 1211, 13412, 28820, 33251, 25720, 12399, 46811, 10943, 22807, 39896, 4117, 3714, 4117, 13063, 3660, 12399, 9154, 4724, 23557], "avg_logprob": -0.2592844289282094, "compression_ratio": 1.681159420289855, "no_speech_prob": 0.0, "words": [{"start": 274.42, "end": 274.84, "word": "هذه", "probability": 0.758056640625}, {"start": 274.84, "end": 275.34, "word": " اللايبو", "probability": 0.60882568359375}, {"start": 275.34, "end": 276.04, "word": " بروتين", "probability": 0.796875}, {"start": 276.04, "end": 276.62, "word": " هذه", "probability": 0.231201171875}, {"start": 276.62, "end": 277.46, "word": " النواقل", "probability": 0.8543701171875}, {"start": 277.46, "end": 278.16, "word": " عادةً", "probability": 0.80548095703125}, {"start": 278.16, "end": 278.56, "word": " شكلها", "probability": 0.9412434895833334}, {"start": 278.56, "end": 278.84, "word": " مثل", "probability": 0.93017578125}, {"start": 278.84, "end": 279.14, "word": " شكل", "probability": 0.9365234375}, {"start": 279.14, "end": 279.66, "word": " الميسل", "probability": 0.7655029296875}, {"start": 279.66, "end": 279.96, "word": " بدنا", "probability": 0.6414794921875}, {"start": 279.96, "end": 280.74, "word": " نتخيلها،", "probability": 0.8833821614583334}, {"start": 280.74, "end": 280.88, "word": " إيش", "probability": 0.7236328125}, {"start": 280.88, "end": 281.1, "word": " يعني", "probability": 0.945068359375}, 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{"start": 401.56, "end": 402.3, "word": " للخلايا", "probability": 0.9617919921875}, {"start": 402.3, "end": 402.76, "word": " اللي", "probability": 0.961669921875}, {"start": 402.76, "end": 403.12, "word": " لازمة", "probability": 0.947265625}, {"start": 403.12, "end": 403.66, "word": " تنتجل", "probability": 0.8917236328125}, {"start": 403.66, "end": 403.84, "word": " من", "probability": 0.99072265625}, {"start": 403.84, "end": 404.24, "word": " الدم", "probability": 0.97705078125}, {"start": 404.24, "end": 405.82, "word": " للخلايا", "probability": 0.8460693359375}, {"start": 405.82, "end": 406.62, "word": " تمام؟", "probability": 0.83349609375}], "temperature": 1.0}, {"id": 20, "seek": 42870, "start": 408.64, "end": 428.7, "text": "الـ four main types of lipoproteins are كايلو مايكرون، VLDL، LDL and HDL الأنواع نواقل الدهون عبارة عن أربع نواقل النواقل الأول بنسميه كايلو مايكرون النواقل التاني بنسميه الـ very low density lipoprotein", "tokens": [6027, 39184, 1451, 2135, 3467, 295, 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"probability": 0.7373046875}, {"start": 426.16, "end": 426.3, "word": " very", "probability": 0.3095703125}, {"start": 426.3, "end": 426.6, "word": " low", "probability": 0.9091796875}, {"start": 426.6, "end": 427.36, "word": " density", "probability": 0.7666015625}, {"start": 427.36, "end": 428.7, "word": " lipoprotein", "probability": 0.96044921875}], "temperature": 1.0}, {"id": 21, "seek": 45086, "start": 429.4, "end": 450.86, "text": "النواقل التالت الـ Low-density lipoprotein والنواقل الرابع الـ High-density lipoprotein هذه كلها نواقل للـ lipids الدهون وبالأخص هذه النواقل هي اللي بتنجل الكلسترول Easter والـ triglyceride تمام؟", "tokens": [6027, 1863, 14407, 4587, 1211, 16712, 6027, 2655, 2423, 39184, 17078, 12, 67, 6859, 8280, 404, 81, 1370, 259, 16070, 1863, 14407, 4587, 1211, 34892, 16758, 3615, 2423, 39184, 5229, 12, 67, 6859, 8280, 404, 81, 1370, 259, 29538, 28242, 11296, 8717, 14407, 4587, 1211, 24976, 39184, 8280, 3742, 32748, 3224, 11536, 46599, 6027, 10721, 9778, 9381, 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"word": " libids", "probability": 0.777587890625}, {"start": 520.66, "end": 521.2, "word": " أو", "probability": 0.9794921875}, {"start": 521.2, "end": 521.44, "word": " بالـ", "probability": 0.832275390625}, {"start": 521.44, "end": 522.56, "word": " degradation،", "probability": 0.768798828125}, {"start": 522.56, "end": 523.62, "word": " بتحطيمها", "probability": 0.8876953125}, {"start": 523.62, "end": 524.18, "word": " أو", "probability": 0.96728515625}, {"start": 524.18, "end": 524.46, "word": " بالـ", "probability": 0.95849609375}, {"start": 524.46, "end": 525.26, "word": " Transporter", "probability": 0.6903076171875}, {"start": 525.26, "end": 525.9, "word": " نفسها", "probability": 0.9957682291666666}, {"start": 525.9, "end": 526.24, "word": " أو", "probability": 0.9794921875}, {"start": 526.24, "end": 527.08, "word": " بنواقل", "probability": 0.94140625}, {"start": 527.08, "end": 527.32, "word": " الـ", "probability": 0.932861328125}, {"start": 527.32, "end": 527.7, "word": " libids", "probability": 0.77734375}, {"start": 527.7, "end": 528.36, "word": " نفسها", "probability": 0.9931640625}, {"start": 528.36, "end": 528.74, "word": " اللي", "probability": 0.963134765625}, {"start": 528.74, "end": 529.4, "word": " هم", "probability": 0.644775390625}, {"start": 529.4, "end": 529.74, "word": " الـ", "probability": 0.724609375}, {"start": 529.74, "end": 530.5, "word": " lipoprotein", "probability": 0.7633544921875}], "temperature": 1.0}, {"id": 26, "seek": 54440, "start": 531.04, "end": 544.4, "text": "ممكن يكون فيهم مشكلة فيهم خلل Increased or decreased plasma lipoproteins are named hyperlipoprotonemia وhypolipoprotonemia respectively", "tokens": [2304, 43020, 7251, 30544, 8978, 16095, 37893, 28820, 3660, 8978, 16095, 16490, 1211, 1211, 30367, 1937, 420, 24436, 22564, 8280, 404, 81, 1370, 1292, 366, 4926, 9848, 75, 647, 404, 10536, 266, 14058, 4032, 3495, 12892, 647, 404, 10536, 266, 14058, 25009], "avg_logprob": -0.17614462694456412, "compression_ratio": 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" are", "probability": 0.8125}, {"start": 538.5, "end": 538.92, "word": " named", "probability": 0.9345703125}, {"start": 538.92, "end": 540.82, "word": " hyperlipoprotonemia", "probability": 0.7684151785714286}, {"start": 540.82, "end": 543.52, "word": " وhypolipoprotonemia", "probability": 0.88623046875}, {"start": 543.52, "end": 544.4, "word": " respectively", "probability": 0.8505859375}], "temperature": 1.0}, {"id": 27, "seek": 57290, "start": 545.38, "end": 572.9, "text": "الارتفاع في نواقل الدهون يعني الارتفاع في الـLiboprotein بنسميها Hyperliboprotonemia والانخفاض في تركيز نواقل الدهون بنسميها الـHyperliboprotonemia Hyperارتفاع وHyperانخفاض Liboprotonemia يقصد فيها نواقل الدهون", "tokens": [6027, 9640, 2655, 5172, 45761, 8978, 8717, 14407, 4587, 1211, 32748, 3224, 11536, 37495, 22653, 2423, 9640, 2655, 5172, 45761, 8978, 2423, 39184, 43, 897, 404, 81, 1370, 259, 44945, 38251, 1829, 11296, 29592, 38270, 404, 10536, 266, 14058, 16070, 7649, 9778, 5172, 46958, 8978, 6055, 31747, 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"end": 568.32, "word": " وHyperانخفاض", "probability": 0.9549386160714286}, {"start": 568.32, "end": 570.18, "word": " Liboprotonemia", "probability": 0.7840576171875}, {"start": 570.18, "end": 570.76, "word": " يقصد", "probability": 0.97998046875}, {"start": 570.76, "end": 571.2, "word": " فيها", "probability": 0.9921875}, {"start": 571.2, "end": 572.16, "word": " نواقل", "probability": 0.995361328125}, {"start": 572.16, "end": 572.9, "word": " الدهون", "probability": 0.9943033854166666}], "temperature": 1.0}, {"id": 28, "seek": 60315, "start": 574.83, "end": 603.15, "text": "Lipids as biochemical markers of disease تعتبر الدهون علامة كيميائية لحدوث مرض معين Clinical chemistry laboratories offer many tests for lipid disorders طبعا أوجدت المختبرات فحوصات بتشيك على وضع الدهون في الجسم one of the most common tests is the lipid profile", "tokens": [43, 647, 3742, 382, 12198, 34114, 19175, 295, 4752, 6055, 34268, 26890, 32748, 3224, 11536, 11203, 10943, 3660, 9122, 32640, 1829, 16373, 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{"start": 679.18, "end": 679.54, "word": " عن", "probability": 0.99658203125}, {"start": 679.54, "end": 680.46, "word": " measurement", "probability": 0.454345703125}, {"start": 680.46, "end": 681.08, "word": " of", "probability": 0.93359375}, {"start": 681.08, "end": 681.94, "word": " قياس", "probability": 0.966796875}, {"start": 681.94, "end": 682.34, "word": " لـ", "probability": 0.8154296875}, {"start": 682.34, "end": 683.44, "word": " triglycerides", "probability": 0.84869384765625}, {"start": 683.44, "end": 684.1, "word": " and", "probability": 0.888671875}, {"start": 684.1, "end": 685.16, "word": " الكوليسترول", "probability": 0.824462890625}], "temperature": 1.0}, {"id": 32, "seek": 70585, "start": 686.27, "end": 705.85, "text": "هي فحسين وقياس الـ Low-density lipoprotein cholesterol الـ LDL-C والـ High-density lipoprotein cholesterol الـ HDL-C بدنا نفهم إن الـ LDL والـ HDL هذي نواقل الدهون", "tokens": [3224, 1829, 6156, 5016, 3794, 9957, 4032, 4587, 25528, 3794, 2423, 39184, 17078, 12, 67, 6859, 8280, 404, 81, 1370, 259, 24716, 2423, 39184, 33936, 43, 12, 34, 16070, 39184, 5229, 12, 67, 6859, 8280, 404, 81, 1370, 259, 24716, 2423, 39184, 12149, 43, 12, 34, 47525, 8315, 8717, 5172, 16095, 36145, 2423, 39184, 33936, 43, 16070, 39184, 12149, 43, 8032, 8848, 1829, 8717, 14407, 4587, 1211, 32748, 3224, 11536], "avg_logprob": -0.1763864407237147, "compression_ratio": 1.5103448275862068, "no_speech_prob": 0.0, "words": [{"start": 686.27, "end": 686.83, "word": "هي", "probability": 0.717529296875}, {"start": 686.83, "end": 687.81, "word": " فحسين", "probability": 0.86279296875}, {"start": 687.81, "end": 689.17, "word": " وقياس", "probability": 0.88427734375}, {"start": 689.17, "end": 689.53, "word": " الـ", "probability": 0.92919921875}, {"start": 689.53, "end": 689.69, "word": " Low", "probability": 0.77001953125}, {"start": 689.69, "end": 690.31, "word": "-density", "probability": 0.6338704427083334}, {"start": 690.31, "end": 691.39, "word": " lipoprotein", "probability": 0.8775390625}, {"start": 691.39, "end": 692.19, "word": " cholesterol", "probability": 0.69384765625}, {"start": 692.19, "end": 692.73, "word": " الـ", "probability": 0.693603515625}, {"start": 692.73, "end": 693.35, "word": " LDL", "probability": 0.81201171875}, {"start": 693.35, "end": 693.87, "word": "-C", "probability": 0.896484375}, {"start": 693.87, "end": 694.69, "word": " والـ", "probability": 0.70556640625}, {"start": 694.69, "end": 694.95, "word": " High", "probability": 0.81005859375}, {"start": 694.95, "end": 695.69, "word": "-density", "probability": 0.9020182291666666}, {"start": 695.69, "end": 697.09, "word": " lipoprotein", "probability": 0.96689453125}, {"start": 697.09, "end": 697.91, "word": " cholesterol", "probability": 0.669921875}, {"start": 697.91, "end": 698.59, "word": " الـ", "probability": 0.949462890625}, {"start": 698.59, "end": 699.33, "word": " HDL", "probability": 0.8349609375}, {"start": 699.33, "end": 699.85, "word": "-C", "probability": 0.990478515625}, {"start": 699.85, "end": 700.59, "word": " بدنا", "probability": 0.846923828125}, {"start": 700.59, "end": 701.07, "word": " نفهم", "probability": 0.9931640625}, {"start": 701.07, "end": 701.53, "word": " إن", "probability": 0.65234375}, {"start": 701.53, "end": 701.83, "word": " الـ", "probability": 0.902587890625}, {"start": 701.83, "end": 702.51, "word": " LDL", "probability": 0.9248046875}, {"start": 702.51, "end": 702.91, "word": " والـ", "probability": 0.77734375}, {"start": 702.91, "end": 703.61, "word": " HDL", "probability": 0.859619140625}, {"start": 703.61, "end": 704.17, "word": " هذي", "probability": 0.6724446614583334}, {"start": 704.17, "end": 705.13, "word": " نواقل", "probability": 0.97509765625}, {"start": 705.13, "end": 705.85, "word": " الدهون", "probability": 0.9705403645833334}], "temperature": 1.0}, {"id": 33, "seek": 72104, "start": 706.22, "end": 721.04, "text": "و بالأخص هذه الـ lipoprotein هذه النواقل تنقل الكوليسترول بشكل أكبر في ناس هتسألني طب تنقل الدهون التلاتية؟ نعم تنقل الدهون التلاتية", "tokens": [2407, 20666, 10721, 9778, 9381, 29538, 2423, 39184, 8280, 404, 81, 1370, 259, 29538, 28239, 14407, 4587, 1211, 6055, 1863, 4587, 1211, 33251, 12610, 1829, 14851, 2288, 12610, 4724, 8592, 28820, 5551, 4117, 26890, 8978, 8717, 32277, 8032, 2655, 3794, 10721, 1211, 22653, 23032, 3555, 6055, 1863, 4587, 1211, 32748, 3224, 11536, 16712, 1211, 9307, 10632, 22807, 8717, 25957, 6055, 1863, 4587, 1211, 32748, 3224, 11536, 16712, 1211, 9307, 10632], "avg_logprob": -0.17451584339141846, "compression_ratio": 1.669064748201439, "no_speech_prob": 0.0, "words": [{"start": 706.22, "end": 706.54, "word": "و", "probability": 0.57421875}, {"start": 706.54, "end": 707.46, "word": " بالأخص", "probability": 0.770263671875}, {"start": 707.46, "end": 707.94, "word": " هذه", "probability": 0.83154296875}, {"start": 707.94, "end": 708.22, "word": " الـ", "probability": 0.76416015625}, {"start": 708.22, "end": 709.26, "word": " lipoprotein", "probability": 0.7943359375}, {"start": 709.26, "end": 709.7, "word": " هذه", "probability": 0.6015625}, {"start": 709.7, "end": 710.48, "word": " النواقل", "probability": 0.878173828125}, {"start": 710.48, "end": 711.54, "word": " تنقل", "probability": 0.980712890625}, {"start": 711.54, "end": 712.78, "word": " الكوليسترول", "probability": 0.908447265625}, {"start": 712.78, "end": 713.34, "word": " بشكل", "probability": 0.9939778645833334}, {"start": 713.34, "end": 713.88, "word": " أكبر", "probability": 0.9461263020833334}, {"start": 713.88, "end": 715.02, "word": " في", "probability": 0.2481689453125}, {"start": 715.02, "end": 715.3, "word": " ناس", "probability": 0.958740234375}, {"start": 715.3, "end": 715.84, "word": " هتسألني", "probability": 0.8978678385416666}, {"start": 715.84, "end": 716.06, "word": " طب", "probability": 0.570556640625}, {"start": 716.06, "end": 716.82, "word": " تنقل", "probability": 0.855712890625}, {"start": 716.82, "end": 717.72, "word": " الدهون", "probability": 0.9786783854166666}, {"start": 717.72, "end": 718.58, "word": " التلاتية؟", "probability": 0.848193359375}, {"start": 718.58, "end": 718.94, "word": " نعم", "probability": 0.956298828125}, {"start": 718.94, "end": 719.68, "word": " تنقل", "probability": 0.9730224609375}, {"start": 719.68, "end": 720.3, "word": " الدهون", "probability": 0.9949544270833334}, {"start": 720.3, "end": 721.04, "word": " التلاتية", "probability": 0.9935302734375}], "temperature": 1.0}, {"id": 34, "seek": 73728, "start": 721.22, "end": 737.28, "text": "ولكن هي بشكل أساسي بتنجلنا الكوليسترول عشان هيك بيسموها HDL و LDL-C خاصة بالكوليسترول مواقل بتحمل جواتها الكوليسترول وبتنجله من البلازمة للخلايا", "tokens": [12610, 19452, 39896, 4724, 8592, 28820, 5551, 3794, 32277, 1829, 39894, 1863, 7435, 1211, 8315, 33251, 12610, 1829, 14851, 2288, 12610, 6225, 8592, 7649, 39896, 4117, 4724, 1829, 38251, 2407, 11296, 12149, 43, 4032, 33936, 43, 12, 34, 16490, 33546, 3660, 20666, 4117, 12610, 1829, 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"temperature": 1.0}, {"id": 38, "seek": 82433, "start": 805.19, "end": 824.33, "text": "بس بدنا نعرف إن ارتفاع الدهون مرتبط ارتباط وسيق بحدوث أمراض القلب والأوعية الدموية it is therefore clear that lipid measurements should be made in all patients known to have vesicular disease and induce at increased risk", "tokens": [3555, 3794, 47525, 8315, 8717, 3615, 28480, 36145, 1975, 43500, 5172, 45761, 32748, 3224, 11536, 3714, 43500, 3555, 9566, 1975, 43500, 3555, 41193, 46952, 1829, 4587, 4724, 24401, 2407, 12984, 5551, 29973, 46958, 25062, 46152, 16070, 10721, 45367, 10632, 32748, 2304, 2407, 10632, 309, 307, 4412, 1850, 300, 8280, 327, 15383, 820, 312, 1027, 294, 439, 4209, 2570, 281, 362, 28274, 14646, 4752, 293, 41263, 412, 6505, 3148], "avg_logprob": -0.13428442720053851, "compression_ratio": 1.3827751196172249, "no_speech_prob": 0.0, "words": [{"start": 805.19, "end": 805.67, "word": "بس", "probability": 0.77490234375}, {"start": 805.67, "end": 806.25, "word": " بدنا", "probability": 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"text": "يفضل إنه نعمل فحص الـ Lipid Profile فحوصات الدمون للمرضى اللي أصلا هما بيعانوا من مشاكل في القوية الدموية الـ Vascular Disease بين فترة و فترة نشيك عليهم و نعملهم الـ Lipids Profile لإنه", "tokens": [33911, 11242, 1211, 36145, 3224, 8717, 25957, 1211, 6156, 5016, 9381, 2423, 39184, 27475, 327, 6039, 794, 6156, 5016, 2407, 9381, 9307, 32748, 2304, 11536, 5296, 19528, 43042, 7578, 13672, 1829, 5551, 9381, 15040, 8032, 15042, 4724, 40228, 7649, 14407, 9154, 37893, 995, 28820, 8978, 25062, 2407, 10632, 32748, 2304, 2407, 10632, 2423, 39184, 691, 22084, 35360, 49374, 6156, 2655, 25720, 4032, 6156, 2655, 25720, 8717, 8592, 1829, 4117, 25894, 16095, 4032, 8717, 25957, 1211, 16095, 2423, 39184, 27475, 3742, 6039, 794, 5296, 28814, 1863, 3224], "avg_logprob": -0.18983477593838483, "compression_ratio": 1.5736842105263158, "no_speech_prob": 0.0, "words": [{"start": 824.88, "end": 825.72, "word": "يفضل", "probability": 0.7763671875}, {"start": 825.72, "end": 826.22, "word": " إنه", "probability": 0.6845703125}, {"start": 826.22, "end": 826.76, "word": " نعمل", "probability": 0.9934895833333334}, {"start": 826.76, "end": 827.46, "word": " فحص", "probability": 0.88330078125}, {"start": 827.46, "end": 827.88, "word": " الـ", "probability": 0.7132568359375}, {"start": 827.88, "end": 828.1, "word": " Lipid", "probability": 0.62548828125}, {"start": 828.1, "end": 828.76, "word": " Profile", "probability": 0.839111328125}, {"start": 828.76, "end": 829.5, "word": " فحوصات", "probability": 0.79638671875}, {"start": 829.5, "end": 830.02, "word": " الدمون", "probability": 0.7156575520833334}, {"start": 830.02, "end": 830.98, "word": " للمرضى", "probability": 0.9415283203125}, {"start": 830.98, "end": 831.26, "word": " اللي", "probability": 0.958251953125}, {"start": 831.26, "end": 831.76, "word": " أصلا", "probability": 0.9127604166666666}, {"start": 831.76, "end": 832.08, "word": " هما", "probability": 0.736328125}, {"start": 832.08, "end": 832.72, "word": " بيعانوا", "probability": 0.9508056640625}, {"start": 832.72, "end": 833.2, "word": " من", "probability": 0.9853515625}, {"start": 833.2, "end": 833.78, "word": " مشاكل", "probability": 0.9627278645833334}, {"start": 833.78, "end": 833.94, "word": " في", "probability": 0.91845703125}, {"start": 833.94, "end": 834.4, "word": " القوية", "probability": 0.703125}, {"start": 834.4, "end": 834.98, "word": " الدموية", "probability": 0.979736328125}, {"start": 834.98, "end": 835.4, "word": " الـ", "probability": 0.822265625}, {"start": 835.4, "end": 835.84, "word": " Vascular", "probability": 0.552001953125}, {"start": 835.84, "end": 836.66, "word": " Disease", "probability": 0.72021484375}, {"start": 836.66, "end": 837.34, "word": " بين", "probability": 0.92041015625}, {"start": 837.34, "end": 837.74, "word": " فترة", "probability": 0.9918619791666666}, {"start": 837.74, "end": 837.86, "word": " و", "probability": 0.98779296875}, {"start": 837.86, "end": 838.26, "word": " فترة", "probability": 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للحالات التالية", "tokens": [1211, 2407, 30767, 18513, 2655, 32748, 3224, 11536, 43242, 16095, 8032, 2655, 11622, 25708, 21542, 6027, 3660, 43242, 16095, 4032, 3224, 2655, 3794, 37983, 25124, 23557, 1829, 9957, 16070, 10721, 13063, 41891, 4724, 8592, 28820, 5551, 4117, 26890, 639, 22564, 8280, 3742, 820, 312, 12690, 294, 264, 5346, 365, 264, 3480, 8032, 1211, 7435, 36081, 35186, 10874, 15042, 27884, 6156, 5016, 9381, 29538, 25724, 2304, 37977, 20449, 8315, 11296, 14739, 3224, 6156, 5016, 9381, 2423, 39184, 43, 647, 3742, 6039, 794, 6156, 5016, 9381, 9307, 32748, 3224, 11536, 39894, 1863, 9566, 46152, 24976, 5016, 6027, 9307, 16712, 6027, 10632], "avg_logprob": -0.1599999998509884, "compression_ratio": 1.5465587044534412, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 842.62, "end": 843.0, "word": "لو", "probability": 0.992919921875}, {"start": 843.0, "end": 843.64, "word": " زادت", "probability": 0.9739583333333334}, {"start": 843.64, "end": 844.2, "word": " الدهون", 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بدنا نعرف يا جماعة أن التركيز الطبيعي للـLDL كوليسترول أقل من 100 milligram per deciliter عند الإنسان الطبيعي", "tokens": [49827, 26184, 14055, 2423, 8315, 3794, 9673, 3215, 9778, 1863, 9957, 4724, 8592, 28820, 3714, 14851, 29973, 46172, 13672, 1829, 43242, 16095, 48812, 17082, 9566, 13672, 1829, 43242, 16095, 6055, 31747, 1829, 11622, 2423, 39184, 33936, 43, 9122, 12610, 1829, 14851, 2288, 12610, 9856, 5551, 3615, 23942, 9154, 21243, 38298, 680, 979, 388, 1681, 47525, 8315, 8717, 3615, 28480, 35186, 10874, 15042, 27884, 14739, 16712, 31747, 1829, 11622, 41950, 21292, 3615, 1829, 24976, 39184, 23704, 43, 9122, 12610, 1829, 14851, 2288, 12610, 5551, 4587, 1211, 9154, 2319, 38298, 680, 979, 388, 1681, 43242, 33688, 1863, 3794, 7649, 41950, 21292, 3615, 1829], "avg_logprob": -0.120710781538019, "compression_ratio": 1.6875, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 1069.28, "end": 1069.74, "word": "current", "probability": 0.432861328125}, {"start": 1069.74, "end": 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{"start": 1078.02, "end": 1078.98, "word": " تركيز", "probability": 0.989990234375}, {"start": 1078.98, "end": 1079.64, "word": " الـ", "probability": 0.785888671875}, {"start": 1079.64, "end": 1080.1, "word": " LDL", "probability": 0.843017578125}, {"start": 1080.1, "end": 1081.08, "word": " كوليسترول", "probability": 0.853271484375}, {"start": 1081.08, "end": 1082.32, "word": " concentration", "probability": 0.61865234375}, {"start": 1082.32, "end": 1083.06, "word": " أعلى", "probability": 0.9475911458333334}, {"start": 1083.06, "end": 1083.28, "word": " من", "probability": 0.9873046875}, {"start": 1083.28, "end": 1084.06, "word": " 160", "probability": 0.71875}, {"start": 1084.06, "end": 1085.14, "word": " milligram", "probability": 0.1795654296875}, {"start": 1085.14, "end": 1085.54, "word": " per", "probability": 0.90478515625}, {"start": 1085.54, "end": 1086.36, "word": " deciliter", "probability": 0.8513997395833334}, {"start": 1086.36, "end": 1087.08, "word": " بدنا", "probability": 0.8359375}, {"start": 1087.08, "end": 1087.4, "word": " نعرف", "probability": 0.9928385416666666}, {"start": 1087.4, "end": 1087.54, "word": " يا", "probability": 0.98046875}, {"start": 1087.54, "end": 1088.04, "word": " جماعة", "probability": 0.99609375}, {"start": 1088.04, "end": 1088.4, "word": " أن", "probability": 0.5166015625}, {"start": 1088.4, "end": 1089.14, "word": " التركيز", "probability": 0.9864501953125}, {"start": 1089.14, "end": 1089.94, "word": " الطبيعي", "probability": 0.9881591796875}, {"start": 1089.94, "end": 1091.46, "word": " للـLDL", "probability": 0.812255859375}, {"start": 1091.46, "end": 1092.58, "word": " كوليسترول", "probability": 0.9366861979166666}, {"start": 1092.58, "end": 1093.36, "word": " أقل", "probability": 0.8738606770833334}, {"start": 1093.36, "end": 1093.8, "word": " من", "probability": 0.99609375}, {"start": 1093.8, "end": 1094.24, "word": " 100", "probability": 0.85400390625}, {"start": 1094.24, "end": 1095.24, "word": " milligram", "probability": 0.97021484375}, {"start": 1095.24, "end": 1095.72, "word": " per", "probability": 0.93212890625}, {"start": 1095.72, "end": 1096.5, "word": " deciliter", "probability": 0.9283854166666666}, {"start": 1096.5, "end": 1096.76, "word": " عند", "probability": 0.98974609375}, {"start": 1096.76, "end": 1097.38, "word": " الإنسان", "probability": 0.9910888671875}, {"start": 1097.38, "end": 1097.98, "word": " الطبيعي", "probability": 0.977294921875}], "temperature": 1.0}, {"id": 51, "seek": 111525, "start": 1098.43, "end": 1115.25, "text": "لو كان أكتر من 100 في عنده الشخص هيكون risk factor للإصابة بأمراض القلب والأوعية الدموية برضه الـ LDL لو كان أكتر من 130 أو زي ما حكتلكم أكتر من 100", "tokens": [1211, 2407, 25961, 5551, 4117, 2655, 2288, 9154, 2319, 8978, 43242, 3224, 25124, 9778, 9381, 39896, 30544, 3148, 5952, 24976, 28814, 9381, 16758, 3660, 4724, 10721, 29973, 46958, 25062, 46152, 16070, 10721, 45367, 10632, 32748, 2304, 2407, 10632, 4724, 43042, 3224, 2423, 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كان الـ HDL أقل من 40 ميلي جرام per ديسميتر الوضع الطبيعي إن الـ HDL عند الإنسان لازم يكون أعلى من أكبر من 60 ميلي جرام per ديسميتر لو كان أقل من 60، هيكون عندنا Risk Factor للإصابة بأمراض القلب", "tokens": [21292, 30544, 34105, 4117, 45892, 479, 15104, 24976, 28814, 9381, 16758, 3660, 20666, 39184, 24199, 822, 13569, 35360, 34051, 11933, 15730, 25961, 2423, 39184, 12149, 43, 5551, 4587, 1211, 9154, 3356, 3714, 1829, 20292, 10874, 2288, 10943, 680, 11778, 1829, 38251, 36081, 2288, 2423, 2407, 11242, 3615, 41950, 21292, 3615, 1829, 36145, 2423, 39184, 12149, 43, 43242, 33688, 1863, 3794, 7649, 5296, 31377, 2304, 7251, 30544, 5551, 3615, 23942, 9154, 5551, 4117, 26890, 9154, 4060, 3714, 1829, 20292, 10874, 2288, 10943, 680, 11778, 1829, 38251, 36081, 2288, 45164, 25961, 5551, 4587, 1211, 9154, 4060, 12399, 39896, 30544, 43242, 8315, 45892, 479, 15104, 24976, 28814, 9381, 16758, 3660, 4724, 10721, 29973, 46958, 25062, 46152], "avg_logprob": -0.13267544225642555, "compression_ratio": 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{"start": 1204.68, "end": 1205.16, "word": " أول", "probability": 0.9521484375}, {"start": 1205.16, "end": 1205.6, "word": " نوع", "probability": 0.99462890625}, {"start": 1205.6, "end": 1206.04, "word": " من", "probability": 0.97998046875}, {"start": 1206.04, "end": 1206.8, "word": " أنواع", "probability": 0.9700520833333334}, {"start": 1206.8, "end": 1207.56, "word": " الدهون", "probability": 0.9368489583333334}, {"start": 1207.56, "end": 1207.98, "word": " اللي", "probability": 0.83642578125}, {"start": 1207.98, "end": 1208.54, "word": " بتكون", "probability": 0.9521484375}, {"start": 1208.54, "end": 1209.38, "word": " موجودة", "probability": 0.9837646484375}, {"start": 1209.38, "end": 1209.5, "word": " في", "probability": 0.95458984375}, {"start": 1209.5, "end": 1209.94, "word": " الدم", "probability": 0.98828125}, {"start": 1209.94, "end": 1210.54, "word": " لـ", "probability": 0.90625}, {"start": 1210.54, "end": 1211.7, "word": " Triglycerides", "probability": 0.8771484375}, {"start": 1211.7, "end": 1212.28, "word": " كتير", "probability": 0.7892252604166666}, {"start": 1212.28, "end": 1212.88, "word": " بنسمع", "probability": 0.9752604166666666}, {"start": 1212.88, "end": 1213.28, "word": " عنه", "probability": 0.98486328125}, {"start": 1213.28, "end": 1214.12, "word": " الدهون", "probability": 0.9781901041666666}, {"start": 1214.12, "end": 1215.28, "word": " التولاتية", "probability": 0.7679443359375}, {"start": 1215.28, "end": 1216.94, "word": " glycerol", "probability": 0.6909586588541666}, {"start": 1216.94, "end": 1217.44, "word": "-packed", "probability": 0.6376546223958334}, {"start": 1217.44, "end": 1217.7, "word": " boon", "probability": 0.5040283203125}, {"start": 1217.7, "end": 1218.14, "word": " with", "probability": 0.912109375}, {"start": 1218.14, "end": 1218.64, "word": " fatty", "probability": 0.958984375}, {"start": 1218.64, "end": 1219.16, "word": " acid", "probability": 0.9091796875}, {"start": 1219.16, "end": 1219.94, "word": " attached", "probability": 0.8154296875}, {"start": 1219.94, "end": 1220.54, "word": " by", "probability": 0.9765625}, {"start": 1220.54, "end": 1221.32, "word": " ester", "probability": 0.5672607421875}, {"start": 1221.32, "end": 1221.9, "word": " bonds", "probability": 0.93359375}], "temperature": 1.0}, {"id": 56, "seek": 123841, "start": 1223.05, "end": 1238.41, "text": "الدهون التلاتية إيش تركيبها؟ تركيبها three fatty acid تلت أحماض دهونية مرتبطة مع إجليسرول بواسطة Easter bond هذه هي الدهون التلاتية", "tokens": [6027, 3215, 3224, 11536, 16712, 1211, 9307, 10632, 11933, 1829, 8592, 6055, 31747, 1829, 3555, 11296, 22807, 6055, 31747, 1829, 3555, 11296, 1045, 24898, 8258, 6055, 1211, 2655, 5551, 35571, 46958, 11778, 3224, 11536, 10632, 3714, 43500, 3555, 9566, 3660, 20449, 11933, 7435, 20292, 3794, 2288, 12610, 4724, 14407, 3794, 9566, 3660, 9403, 6086, 29538, 39896, 32748, 3224, 11536, 16712, 1211, 9307, 10632], "avg_logprob": -0.20312500256113708, "compression_ratio": 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{"start": 1230.33, "end": 1231.67, "word": " مرتبطة", "probability": 0.98056640625}, {"start": 1231.67, "end": 1232.21, "word": " مع", "probability": 0.93505859375}, {"start": 1232.21, "end": 1233.65, "word": " إجليسرول", "probability": 0.7628987630208334}, {"start": 1233.65, "end": 1234.91, "word": " بواسطة", "probability": 0.98095703125}, {"start": 1234.91, "end": 1235.51, "word": " Easter", "probability": 0.324951171875}, {"start": 1235.51, "end": 1236.05, "word": " bond", "probability": 0.52734375}, {"start": 1236.05, "end": 1236.59, "word": " هذه", "probability": 0.662109375}, {"start": 1236.59, "end": 1236.85, "word": " هي", "probability": 0.91796875}, {"start": 1236.85, "end": 1237.47, "word": " الدهون", "probability": 0.9928385416666666}, {"start": 1237.47, "end": 1238.41, "word": " التلاتية", "probability": 0.9937744140625}], "temperature": 1.0}, {"id": 57, "seek": 125609, "start": 1240.24, "end": 1256.1, "text": "3 أحماض دهنية مربوطين بالجليسرول بواسطة Easter bond طبعا الشكل مش مطلوب نحفظه ولا مطلوب نعرف تركيبة الشكل", "tokens": [18, 5551, 35571, 46958, 11778, 3224, 1863, 10632, 3714, 25513, 2407, 9566, 9957, 20666, 7435, 20292, 3794, 2288, 12610, 4724, 14407, 3794, 9566, 3660, 9403, 6086, 23032, 3555, 3615, 995, 25124, 28820, 37893, 3714, 9566, 1211, 37746, 8717, 5016, 5172, 19913, 3224, 49429, 3714, 9566, 1211, 37746, 8717, 3615, 28480, 6055, 31747, 1829, 49401, 25124, 28820], "avg_logprob": -0.19627192773317037, "compression_ratio": 1.338235294117647, "no_speech_prob": 1.3113021850585938e-06, "words": [{"start": 1240.24, "end": 1240.62, "word": "3", "probability": 0.439208984375}, {"start": 1240.62, "end": 1241.4, "word": " أحماض", "probability": 0.7914225260416666}, {"start": 1241.4, "end": 1241.94, "word": " دهنية", "probability": 0.8431396484375}, {"start": 1241.94, "end": 1244.78, "word": " مربوطين", "probability": 0.8556640625}, {"start": 1244.78, "end": 1246.1, "word": " بالجليسرول", "probability": 0.780029296875}, {"start": 1246.1, "end": 1247.2, "word": " بواسطة", "probability": 0.972265625}, {"start": 1247.2, "end": 1247.74, "word": " Easter", "probability": 0.52197265625}, {"start": 1247.74, "end": 1248.34, "word": " bond", "probability": 0.56201171875}, {"start": 1248.34, "end": 1251.08, "word": " طبعا", "probability": 0.7623291015625}, {"start": 1251.08, "end": 1251.54, "word": " الشكل", "probability": 0.956787109375}, {"start": 1251.54, "end": 1252.02, "word": " مش", "probability": 0.85498046875}, {"start": 1252.02, "end": 1252.62, "word": " مطلوب", "probability": 0.9530029296875}, {"start": 1252.62, "end": 1253.34, "word": " نحفظه", "probability": 0.92373046875}, {"start": 1253.34, "end": 1253.48, "word": " ولا", "probability": 0.84326171875}, {"start": 1253.48, "end": 1254.28, "word": " مطلوب", "probability": 0.8975830078125}, {"start": 1254.28, "end": 1254.72, "word": " نعرف", "probability": 0.986328125}, {"start": 1254.72, "end": 1255.66, "word": " تركيبة", "probability": 0.867431640625}, {"start": 1255.66, "end": 1256.1, "word": " الشكل", "probability": 0.9638671875}], "temperature": 1.0}, {"id": 58, "seek": 128157, "start": 1256.95, "end": 1281.57, "text": "الـ sources of triglycerides إيش مصادر الدهون التلاتية؟يلها مصدرين يا جماعة exogenous sources مصادر خارجية وindigenous sources مصادر داخلية مصادر خارجية من الـ diet من الأكل يعني في كتير أكلات بتكون مليانة دهون تلاتية إذا أكلنا تمام", "tokens": [6027, 39184, 7139, 295, 35386, 356, 1776, 1875, 11933, 1829, 8592, 3714, 9381, 18513, 2288, 32748, 3224, 11536, 16712, 1211, 9307, 10632, 22807, 26895, 11296, 3714, 9381, 3215, 2288, 9957, 35186, 10874, 15042, 27884, 454, 45519, 7139, 3714, 9381, 18513, 2288, 16490, 9640, 7435, 10632, 4032, 471, 11214, 7139, 3714, 9381, 18513, 2288, 11778, 47283, 1211, 10632, 3714, 9381, 18513, 2288, 16490, 9640, 7435, 10632, 9154, 2423, 39184, 6339, 9154, 16247, 28820, 37495, 22653, 8978, 9122, 2655, 13546, 5551, 28820, 9307, 39894, 30544, 3714, 20292, 7649, 3660, 11778, 3224, 11536, 6055, 1211, 9307, 10632, 11933, 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" من", "probability": 0.99560546875}, {"start": 1271.79, "end": 1272.05, "word": " الـ", "probability": 0.801513671875}, {"start": 1272.05, "end": 1272.37, "word": " diet", "probability": 0.85400390625}, {"start": 1272.37, "end": 1272.75, "word": " من", "probability": 0.630859375}, {"start": 1272.75, "end": 1273.31, "word": " الأكل", "probability": 0.96044921875}, {"start": 1273.31, "end": 1273.89, "word": " يعني", "probability": 0.866455078125}, {"start": 1273.89, "end": 1274.27, "word": " في", "probability": 0.927734375}, {"start": 1274.27, "end": 1274.81, "word": " كتير", "probability": 0.9651692708333334}, {"start": 1274.81, "end": 1275.59, "word": " أكلات", "probability": 0.9646809895833334}, {"start": 1275.59, "end": 1277.55, "word": " بتكون", "probability": 0.913330078125}, {"start": 1277.55, "end": 1278.49, "word": " مليانة", "probability": 0.968994140625}, {"start": 1278.49, "end": 1278.91, "word": " دهون", "probability": 0.9820963541666666}, {"start": 1278.91, "end": 1279.59, 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26895, 2407, 19446, 1829, 37983, 11536], "avg_logprob": -0.12886905216035388, "compression_ratio": 1.8829787234042554, "no_speech_prob": 0.0, "words": [{"start": 1338.52, "end": 1339.02, "word": "تمام", "probability": 0.811767578125}, {"start": 1339.02, "end": 1340.0, "word": " فانتبهوا", "probability": 0.9443359375}, {"start": 1340.0, "end": 1340.32, "word": " معايا", "probability": 0.7823079427083334}, {"start": 1340.32, "end": 1341.3, "word": " إذا", "probability": 0.861328125}, {"start": 1341.3, "end": 1341.82, "word": " كان", "probability": 0.99560546875}, {"start": 1341.82, "end": 1342.96, "word": " مصدر", "probability": 0.99658203125}, {"start": 1342.96, "end": 1343.88, "word": " الدهون", "probability": 0.9723307291666666}, {"start": 1343.88, "end": 1344.84, "word": " التلاتية", "probability": 0.90234375}, {"start": 1344.84, "end": 1345.56, "word": " من", "probability": 0.98291015625}, {"start": 1345.56, "end": 1346.22, "word": " الأكل", "probability": 0.9716796875}, {"start": 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نواقل الدهون وبشكل أثاثي بينجل لـ triglyceride اللي بيكون مصدرها خارجي من الـ diet", "tokens": [6027, 4117, 995, 26895, 2407, 19446, 1829, 37983, 11536, 31439, 8717, 45367, 9154, 14739, 14407, 3615, 8717, 14407, 4587, 1211, 32748, 3224, 11536, 46599, 8592, 28820, 5551, 12984, 5718, 104, 1829, 4724, 9957, 7435, 1211, 5296, 39184, 35386, 356, 1776, 482, 13672, 1829, 4724, 1829, 30544, 3714, 9381, 3215, 2288, 11296, 16490, 9640, 7435, 1829, 9154, 2423, 39184, 6339], "avg_logprob": -0.18815104340513547, "compression_ratio": 1.3884892086330936, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1362.27, "end": 1363.45, "word": "الكايلو", "probability": 0.682373046875}, {"start": 1363.45, "end": 1364.03, "word": " مايكرون", "probability": 0.8182373046875}, {"start": 1364.03, "end": 1364.63, "word": " هو", "probability": 0.6181640625}, {"start": 1364.63, "end": 1365.55, "word": " نوع", "probability": 0.932861328125}, {"start": 1365.55, "end": 1365.75, "word": " من", "probability": 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الـ", "probability": 0.88134765625}, {"start": 1385.47, "end": 1386.75, "word": " triglyceride", "probability": 0.758941650390625}, {"start": 1386.75, "end": 1387.33, "word": " اللي", "probability": 0.883544921875}, {"start": 1387.33, "end": 1388.25, "word": " مصدرها", "probability": 0.9916015625}, {"start": 1388.25, "end": 1388.51, "word": " من", "probability": 0.99462890625}, {"start": 1388.51, "end": 1389.31, "word": " الأكل", "probability": 0.980224609375}, {"start": 1389.31, "end": 1391.01, "word": " تمام،", "probability": 0.7246907552083334}, {"start": 1391.01, "end": 1391.29, "word": " هل", "probability": 0.87646484375}, {"start": 1391.29, "end": 1391.45, "word": " جيت", "probability": 0.76904296875}, {"start": 1391.45, "end": 1391.85, "word": " حكينا", "probability": 0.96484375}, {"start": 1391.85, "end": 1392.05, "word": " إن", "probability": 0.62158203125}, {"start": 1392.05, "end": 1392.21, "word": " الـ", "probability": 0.4417724609375}, {"start": 1392.21, "end": 1392.43, "word": " liver", "probability": 0.92724609375}, {"start": 1392.43, "end": 1393.37, "word": " بيكوّن", "probability": 0.7991129557291666}, {"start": 1393.37, "end": 1393.59, "word": " الـ", "probability": 0.81005859375}, {"start": 1393.59, "end": 1394.61, "word": " triglyceride", "probability": 0.935302734375}, {"start": 1394.61, "end": 1395.57, "word": " وبالتالي", "probability": 0.86953125}, {"start": 1395.57, "end": 1395.97, "word": " بوصل", "probability": 0.8821614583333334}, {"start": 1395.97, "end": 1396.29, "word": " الـ", "probability": 0.737060546875}, {"start": 1396.29, "end": 1397.17, "word": " triglyceride", "probability": 0.9696044921875}, {"start": 1397.17, "end": 1397.61, "word": " على", "probability": 0.9111328125}, {"start": 1397.61, "end": 1398.23, "word": " الدم،", "probability": 0.8743489583333334}, {"start": 1398.23, "end": 1398.65, "word": " هل", "probability": 0.989013671875}, {"start": 1398.65, "end": 1398.85, "word": " جيت", "probability": 0.914794921875}, {"start": 1398.85, "end": 1399.19, "word": " الـ", "probability": 0.617431640625}, {"start": 1399.19, "end": 1400.37, "word": " triglyceride؟", "probability": 0.955859375}], "temperature": 1.0}, {"id": 64, "seek": 142867, "start": 1400.45, "end": 1428.67, "text": "اللي مصدره من الكبد مين بينجله؟ بينجله معاقل آخر اسمه الـ VLDL الـ Very Low Density Liboiprotein بينقل بشكل أساسي لـ Triglyceride اللي بيكون مصدره من الكبد اللي اتصنع فيه الكبد، تمام؟ إذا حسب المصدر تبع الـ Triglyceride", "tokens": [6027, 20292, 3714, 9381, 3215, 2288, 3224, 9154, 33251, 44510, 3714, 9957, 4724, 9957, 7435, 43761, 22807, 4724, 9957, 7435, 43761, 20449, 995, 4587, 1211, 19753, 34740, 24525, 2304, 3224, 2423, 39184, 691, 23704, 43, 2423, 39184, 4372, 17078, 413, 6859, 441, 27776, 647, 81, 1370, 259, 4724, 9957, 4587, 1211, 4724, 8592, 28820, 5551, 3794, 32277, 1829, 5296, 39184, 1765, 328, 356, 1776, 482, 13672, 1829, 4724, 1829, 30544, 3714, 9381, 3215, 2288, 3224, 9154, 33251, 44510, 13672, 1829, 1975, 2655, 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1438.1, "end": 1438.32, "word": " كان", "probability": 0.9970703125}, {"start": 1438.32, "end": 1438.72, "word": " مصدر", "probability": 0.994140625}, {"start": 1438.72, "end": 1439.1, "word": " الدهون", "probability": 0.9593098958333334}, {"start": 1439.1, "end": 1439.78, "word": " التلاتية", "probability": 0.882080078125}, {"start": 1439.78, "end": 1440.04, "word": " من", "probability": 0.9794921875}, {"start": 1440.04, "end": 1440.62, "word": " الكبد", "probability": 0.78466796875}, {"start": 1440.62, "end": 1441.04, "word": " مين", "probability": 0.91455078125}, {"start": 1441.04, "end": 1441.2, "word": " اللي", "probability": 0.986572265625}, {"start": 1441.2, "end": 1442.1, "word": " هينجلو؟", "probability": 0.9306640625}, {"start": 1442.1, "end": 1442.58, "word": " الـ", "probability": 0.88623046875}, {"start": 1442.58, "end": 1443.78, "word": " VLDL", "probability": 0.9519856770833334}, {"start": 1443.78, "end": 1444.34, "word": " لو", "probability": 0.94189453125}, {"start": 1444.34, "end": 1445.04, "word": " سألناكم", "probability": 0.95595703125}, {"start": 1445.04, "end": 1445.62, "word": " سؤال", "probability": 0.9894205729166666}, {"start": 1445.62, "end": 1446.58, "word": " الـ", "probability": 0.918701171875}, {"start": 1446.58, "end": 1447.7, "word": " VLDL", "probability": 0.9466145833333334}, {"start": 1447.7, "end": 1448.08, "word": " الـ", "probability": 0.90283203125}, {"start": 1448.08, "end": 1448.36, "word": " Very", "probability": 0.472900390625}, {"start": 1448.36, "end": 1448.84, "word": " Low", "probability": 0.708984375}, {"start": 1448.84, "end": 1449.52, "word": " Density", "probability": 0.946533203125}, {"start": 1449.52, "end": 1450.5, "word": " Liboprotein", "probability": 0.6493408203125}, {"start": 1450.5, "end": 1450.92, "word": " هل", "probability": 0.920166015625}, {"start": 1450.92, "end": 1451.24, "word": " هو", "probability": 0.9951171875}, {"start": 1451.24, "end": 1452.0, "word": " ناقل", "probability": 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reasons هلجيت يا جماعة؟", "tokens": [21292, 35571, 1211, 9122, 12610, 1829, 14851, 2288, 12610, 35525, 19452, 44945, 35457, 3660, 12174, 20292, 37977, 37495, 22653, 31439, 4724, 9957, 7435, 1211, 9122, 12610, 1829, 14851, 2288, 12610, 9122, 2304, 7649, 35525, 19452, 37893, 4724, 8592, 28820, 5551, 3794, 32277, 1829, 36145, 15042, 31439, 4724, 8592, 28820, 5551, 3794, 32277, 1829, 3714, 9381, 2304, 2304, 24976, 3215, 3224, 11536, 16712, 1211, 9307, 10632, 12399, 46811, 10943, 22807, 1765, 328, 356, 1776, 1875, 12399, 32755, 35386, 356, 1776, 1875, 15383, 366, 1096, 337, 264, 3480, 9115, 4112, 8032, 1211, 7435, 36081, 35186, 10874, 15042, 27884, 22807], "avg_logprob": -0.14078444440145882, "compression_ratio": 1.5570175438596492, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1457.47, "end": 1458.11, "word": "بيحمل", "probability": 0.9366861979166666}, {"start": 1458.11, "end": 1458.89, "word": " كوليسترول", "probability": 0.8730875651041666}, {"start": 1458.89, "end": 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"end": 1836.04, "text": "فلما الميّه يسيرلها الـ Shift تطلع من الـ RBCs", "tokens": [5172, 1211, 15042, 9673, 1829, 11703, 3224, 7251, 3794, 13546, 1211, 11296, 2423, 39184, 28304, 6055, 9566, 1211, 3615, 9154, 2423, 39184, 497, 7869, 82], "avg_logprob": -0.18960336366525063, "compression_ratio": 1.1194029850746268, "no_speech_prob": 0.0, "words": [{"start": 1831.68, "end": 1832.16, "word": "فلما", "probability": 0.8068033854166666}, {"start": 1832.16, "end": 1832.62, "word": " الميّه", "probability": 0.85205078125}, {"start": 1832.62, "end": 1833.2, "word": " يسيرلها", "probability": 0.8806640625}, {"start": 1833.2, "end": 1833.42, "word": " الـ", "probability": 0.65576171875}, {"start": 1833.42, "end": 1833.74, "word": " Shift", "probability": 0.5048828125}, {"start": 1833.74, "end": 1834.52, "word": " تطلع", "probability": 0.939697265625}, {"start": 1834.52, "end": 1834.76, "word": " من", "probability": 0.98974609375}, {"start": 1834.76, "end": 1835.06, "word": " الـ", 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196637, "start": 1948.47, "end": 1966.37, "text": "طب هل عالية كتير لإنه ماكل أكلات فيها دهون تلاتية ولا عالية كتير لإنه عنده مشاكل أصلا في الدهون التلاتية في الجسم مش هقدر أميز since elevated لـ triglyceride levels", "tokens": [9566, 3555, 8032, 1211, 6225, 6027, 10632, 9122, 2655, 13546, 5296, 28814, 1863, 3224, 19446, 28820, 5551, 28820, 9307, 8978, 11296, 11778, 3224, 11536, 6055, 1211, 9307, 10632, 49429, 6225, 6027, 10632, 9122, 2655, 13546, 5296, 28814, 1863, 3224, 43242, 3224, 37893, 995, 28820, 5551, 9381, 15040, 8978, 32748, 3224, 11536, 16712, 1211, 9307, 10632, 8978, 25724, 38251, 37893, 8032, 28543, 2288, 5551, 2304, 1829, 11622, 1670, 23457, 5296, 39184, 35386, 356, 1776, 482, 4358], "avg_logprob": -0.12787828516019017, "compression_ratio": 1.6441717791411044, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1948.47, "end": 1948.79, "word": "طب", "probability": 0.632568359375}, {"start": 1948.79, "end": 1949.19, "word": " هل", "probability": 0.92333984375}, 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2009.15, "word": " لـ", "probability": 0.869140625}, {"start": 2009.15, "end": 2010.39, "word": " Triglyceride", "probability": 0.752783203125}, {"start": 2010.39, "end": 2011.27, "word": " كتات", "probability": 0.8544921875}, {"start": 2011.27, "end": 2011.89, "word": " لـ", "probability": 0.940185546875}, {"start": 2011.89, "end": 2013.05, "word": " Triglyceride", "probability": 0.9326171875}, {"start": 2013.05, "end": 2014.03, "word": " مبدأها", "probability": 0.9296875}, {"start": 2014.03, "end": 2014.91, "word": " Enzymatic", "probability": 0.7294921875}, {"start": 2014.91, "end": 2015.35, "word": " method", "probability": 0.9619140625}, {"start": 2015.35, "end": 2016.13, "word": " أغلبها", "probability": 0.9786376953125}, {"start": 2016.13, "end": 2016.77, "word": " بيشتغل", "probability": 0.9736328125}, {"start": 2016.77, "end": 2017.61, "word": " بطريقة", "probability": 0.9659423828125}, {"start": 2017.61, "end": 2018.75, "word": " الانزيمات", "probability": 0.80947265625}, {"start": 2018.75, "end": 2019.27, "word": " هاي", "probability": 0.673828125}, {"start": 2019.27, "end": 2019.37, "word": " ال", "probability": 0.9208984375}, {"start": 2019.37, "end": 2019.71, "word": " slide", "probability": 0.90673828125}, {"start": 2019.71, "end": 2020.13, "word": " اللي", "probability": 0.899658203125}, {"start": 2020.13, "end": 2020.81, "word": " أمامنا", "probability": 0.9537353515625}, {"start": 2020.81, "end": 2021.49, "word": " هي", "probability": 0.8515625}, {"start": 2021.49, "end": 2022.69, "word": " يعني", "probability": 0.787109375}, {"start": 2022.69, "end": 2023.75, "word": " هنشرحها", "probability": 0.939453125}, {"start": 2023.75, "end": 2024.59, "word": " ولكن", "probability": 0.87451171875}, {"start": 2024.59, "end": 2025.37, "word": " بشكل", "probability": 0.9943033854166666}, {"start": 2025.37, "end": 2026.77, "word": " مختصر", "probability": 0.9801025390625}, {"start": 2026.77, "end": 2027.55, "word": " وأفضل", "probability": 0.8941650390625}, {"start": 2027.55, "end": 2027.73, "word": " من", "probability": 0.9970703125}, {"start": 2027.73, "end": 2028.13, "word": " هيك", "probability": 0.938720703125}, {"start": 2028.13, "end": 2028.37, "word": " بال", "probability": 0.9111328125}, {"start": 2028.37, "end": 2028.89, "word": " slide", "probability": 0.78173828125}, {"start": 2028.89, "end": 2029.31, "word": " اللي", "probability": 0.985107421875}, {"start": 2029.31, "end": 2029.73, "word": " بعيدها", "probability": 0.88916015625}, {"start": 2029.73, "end": 2030.25, "word": " تمام؟", "probability": 0.8772786458333334}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2031.8156875, "duration_after_vad": 1996.1293749999966}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/_KHiyilTHZ0_raw.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/_KHiyilTHZ0_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..83ce91382db3bf07909e9d3b9c00b9ffacbd2b50
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/_KHiyilTHZ0_raw.srt
@@ -0,0 +1,1600 @@
+1
+00:00:00,810 --> 00:00:04,390
+السلام عليكم ورحمة الله وبركاته يعطيكم العافية
+
+2
+00:00:04,390 --> 00:00:08,790
+جميعا ان شاء الله اليوم موضوعنا lipid profiling
+
+3
+00:00:08,790 --> 00:00:14,660
+فحوصات الدهوننحكي عن الـ Introduction The major
+
+4
+00:00:14,660 --> 00:00:17,920
+lipids present in the plasma are fatty acids,
+
+5
+00:00:18,080 --> 00:00:20,780
+triglycerides, cholesterol and phospholipids
+
+6
+00:00:20,780 --> 00:00:27,180
+بيحكيلي إنه الدهون الأساسية اللي موجودة في بلازمة
+
+7
+00:00:27,180 --> 00:00:32,560
+الدم هي عبارة عن fatty acid أحماض دهونية،
+
+8
+00:00:32,560 --> 00:00:37,840
+triglycerides، دهون طولاتيةالكلسترول كلنا عارفين
+
+9
+00:00:37,840 --> 00:00:42,500
+الكلسترول and الـphospholipids اللي هي دهون مربوطة
+
+10
+00:00:42,500 --> 00:00:47,940
+بـphosphate group إذا هذه هي الدهون الأساسية اللي
+
+11
+00:00:47,940 --> 00:00:52,440
+موجودة في بلازمة الدم other lipid-soluble
+
+12
+00:00:52,440 --> 00:00:56,560
+substances present in much smaller amounts example
+
+13
+00:00:56,560 --> 00:01:02,470
+steroid hormonesبحكي لي إن في هناك مواد هذه المواد
+
+14
+00:01:02,470 --> 00:01:08,830
+دائمة في الدهون اللي موجودة في بلازمة الدم وهذه
+
+15
+00:01:08,830 --> 00:01:13,210
+الـsubstance اللي دائمة في الدهون موجودة في
+
+16
+00:01:13,210 --> 00:01:18,010
+البلازمة بـsmall amounts بكميات قليلة وهي
+
+17
+00:01:18,010 --> 00:01:22,250
+الـsteroid hormoneإذاً الـSteroid Hormones هذه
+
+18
+00:01:22,250 --> 00:01:27,190
+الهرمونات دائبة في الـLipids اللي بتكون موجودة في
+
+19
+00:01:27,190 --> 00:01:31,910
+البلازمة وتركيز الـSteroid Hormone عادة بتكون
+
+20
+00:01:31,910 --> 00:01:36,710
+قليلة في البلازمة elevated plasma concentrations
+
+21
+00:01:36,710 --> 00:01:40,990
+of lipids particularly cholesterol are related to
+
+22
+00:01:40,990 --> 00:01:46,250
+the pathogenesis of atherosclerosis بيحكيلي ارتفاع
+
+23
+00:01:46,250 --> 00:01:52,050
+مستوى الدهونوتركيز الدهون في البلازمة لما بتزيد
+
+24
+00:01:52,050 --> 00:01:58,830
+وبالأخص الكوليسترول هذا مرتبط ارتباط وثيق بحدوث
+
+25
+00:01:58,830 --> 00:02:04,550
+تصلب الشرايين إذا تصلب الشرايين ثبت من أسبابه هو
+
+26
+00:02:04,550 --> 00:02:13,200
+ارتفاع الدهون في بلازمة الدمLipids transport نقل
+
+27
+00:02:13,200 --> 00:02:17,660
+الدهون في البلازمة Lipids are carried in the
+
+28
+00:02:17,660 --> 00:02:22,520
+bloodstream by complexes known as lipoproteins
+
+29
+00:02:22,520 --> 00:02:26,680
+بدنا نعرف هال gate لو الإنسان اتناول أكل مليان
+
+30
+00:02:26,680 --> 00:02:33,290
+دهونأو الجسم صنع هذه الدهون في الآخر الدهون هتكون
+
+31
+00:02:33,290 --> 00:02:37,130
+موجودة في الـ blood stream في الدم في الـ plasma
+
+32
+00:02:37,130 --> 00:02:43,030
+هلجت هذه الدهون لو بدها تنتقل من الدم إلى أنسجة
+
+33
+00:02:43,030 --> 00:02:47,550
+الجسم إلى خلايا الجسم عشان الخلايا أحيانا تحتاج
+
+34
+00:02:47,550 --> 00:02:53,000
+إلى دهون عشان تشتغل أو عشان تتكونوبالتالي الدهون
+
+35
+00:02:53,000 --> 00:02:58,160
+Insoluble in بلازمة غير دائبة في بلازمة الدم
+
+36
+00:02:58,160 --> 00:03:03,320
+وبالتالي ماتتقدر الدهون تتحرك بشكل free في
+
+37
+00:03:03,320 --> 00:03:08,380
+البلازمة ماتتقدر تمشي لحالها وبالتالي تحتاج إلى
+
+38
+00:03:08,380 --> 00:03:14,200
+Transporter إلى مواقل تنجلها من مكان لمكان مواقل
+
+39
+00:03:14,200 --> 00:03:20,530
+الدهون سموها لايبو بروتينهي بالاصل المواقع عبارة
+
+40
+00:03:20,530 --> 00:03:25,390
+عن البروتينات فسموها الـLiboproteins يعني بروتينات
+
+41
+00:03:25,390 --> 00:03:31,640
+تنقل الليبد كلمة لايبو من الليبدإذاً لبدز are
+
+42
+00:03:31,640 --> 00:03:35,660
+carried in the bloodstream by complexes known as
+
+43
+00:03:35,660 --> 00:03:41,300
+lipoprotein الدهون تنقل في الدم من خلال البروتينات
+
+44
+00:03:41,300 --> 00:03:46,180
+سمنها هذه البروتينات عبارة عن نواقل سمنها الـ
+
+45
+00:03:46,180 --> 00:03:50,520
+lipoproteins نواقل الدهونThis is because these
+
+46
+00:03:50,520 --> 00:03:54,260
+lipids are not soluble in the plasma water ليش؟
+
+47
+00:03:54,260 --> 00:04:00,040
+أنا بدي نواقل للدهون لإن الدهون بطبيعتها لا تذوب
+
+48
+00:04:00,040 --> 00:04:05,460
+في بلازمة الدم ما تقدر تمشي في البلازمة بشكل إفري
+
+49
+00:04:06,340 --> 00:04:10,400
+This they travel in micelle-like complexes
+
+50
+00:04:10,400 --> 00:04:14,460
+composed of phospholipid, cholesterol and protein
+
+51
+00:04:14,460 --> 00:04:18,560
+on the outside with cholesterol easter and
+
+52
+00:04:18,560 --> 00:04:23,640
+triglyceride on the inside هلجيت بيشرحلي شكل
+
+53
+00:04:23,640 --> 00:04:28,860
+النواقل؟ النواقل التفاجنة هي بروتينات تنقل الدهون
+
+54
+00:04:28,860 --> 00:04:33,580
+فسموها الـLiboprotein بروتينات تنقل الليبو تنقل
+
+55
+00:04:33,580 --> 00:04:38,560
+الليبدهذه اللايبو بروتين هذه النواقل عادةً شكلها
+
+56
+00:04:38,560 --> 00:04:42,480
+مثل شكل الميسل بدنا نتخيلها، إيش يعني الميسل؟ مثل
+
+57
+00:04:42,480 --> 00:04:50,670
+شكل الكرة، تمام؟ هيك مكورة، من برامن برا التركيبة
+
+58
+00:04:50,670 --> 00:04:55,370
+تبعتها هي بروتينات وبالتالي هذه الكورة الميسن
+
+59
+00:04:55,370 --> 00:05:02,030
+outside من برا عبارة عن بروتين تمام؟ وعبارة عن
+
+60
+00:05:02,030 --> 00:05:06,950
+فوسفوليبيد وكلسترول إذا التركيبة الخارجية
+
+61
+00:05:06,950 --> 00:05:13,570
+لـLiboproteins لنواقل الدهون من برا تركبتها
+
+62
+00:05:14,290 --> 00:05:18,910
+البروتين و الـ Phospholipid و الكوليسترول أما من
+
+63
+00:05:18,910 --> 00:05:24,530
+الداخل فهي من الداخل بتحط الدهون اللي بدها تنجلها
+
+64
+00:05:24,530 --> 00:05:30,590
+عشان تنجلها من مكان إلى مكان آخر وبالتالي جواتها
+
+65
+00:05:30,590 --> 00:05:37,430
+إما هيكون يعني هيكون جوا هذه النواقل كوليسترول و
+
+66
+00:05:37,430 --> 00:05:43,210
+Triglycerideبس الـ cholesterol اللي بتنجله بيكون
+
+67
+00:05:43,210 --> 00:05:47,810
+على شكل كليسترول إيستر إيش يعني كليسترول إيستر؟
+
+68
+00:05:47,810 --> 00:05:53,510
+يعني كليسترول مربوط بـ fatty acid بأحماض دهنية
+
+69
+00:05:53,510 --> 00:05:58,650
+بواسطة إيستر بوند يعني مش كليسترول free لحاله لأ
+
+70
+00:05:58,650 --> 00:06:03,990
+إنما كليسترول مع fatty acid مربوطين مع بعض بإيستر
+
+71
+00:06:03,990 --> 00:06:09,310
+بوندهيكون جواد هذه النواقل و لـ Triglyceride برضه
+
+72
+00:06:09,310 --> 00:06:13,110
+هي الدهون
+
+73
+00:06:13,110 --> 00:06:20,170
+التلاتية اذا تركيبة اللايبو بروتين تركيبة النواقل
+
+74
+00:06:20,170 --> 00:06:26,860
+كالاتينمن برا الـ membrane تبعها عبارة عن بروتين و
+
+75
+00:06:26,860 --> 00:06:32,820
+phospholipid و كلسترول و من جوا بتنجل الدهون اللي
+
+76
+00:06:32,820 --> 00:06:37,780
+بدها تنجلها بتنجل الـ triglyceride و بتنجل الـ
+
+77
+00:06:37,780 --> 00:06:41,560
+cholesterol ester هذه الدهون الأساسية اللي لازمة
+
+78
+00:06:41,560 --> 00:06:48,860
+للخلايا اللي لازمة تنتجل من الدم للخلايا تمام؟الـ
+
+79
+00:06:48,860 --> 00:06:53,720
+four main types of lipoproteins are كايلو مايكرون،
+
+80
+00:06:53,720 --> 00:06:59,940
+VLDL، LDL and HDL الأنواع نواقل الدهون عبارة عن
+
+81
+00:06:59,940 --> 00:07:03,660
+أربع نواقل النواقل الأول بنسميه كايلو مايكرون
+
+82
+00:07:03,660 --> 00:07:07,360
+النواقل التاني بنسميه الـ very low density
+
+83
+00:07:07,360 --> 00:07:12,180
+lipoproteinالنواقل التالت الـ Low-density
+
+84
+00:07:12,180 --> 00:07:16,260
+lipoprotein والنواقل الرابع الـ High-density
+
+85
+00:07:16,260 --> 00:07:21,880
+lipoprotein هذه كلها نواقل للـ lipids الدهون
+
+86
+00:07:21,880 --> 00:07:28,020
+وبالأخص هذه النواقل هي اللي بتنجل الكلسترول Easter
+
+87
+00:07:28,020 --> 00:07:34,540
+والـ triglyceride تمام؟أهمية الفحص لـ Clinical
+
+88
+00:07:34,540 --> 00:07:38,900
+Significance كوليسترول و الـ Triglycerides مثل
+
+89
+00:07:38,900 --> 00:07:42,860
+العديد من الأشياء الأساسية للجسم تدفع إهتمام
+
+90
+00:07:42,860 --> 00:07:48,340
+كلينيكال عندما يتواجد في مركزات غير عادية بيحكي لي
+
+91
+00:07:48,340 --> 00:07:54,260
+هناإن الكوليسترول والـ triglycerides هذه دهون
+
+92
+00:07:54,260 --> 00:07:59,940
+أساسية بيحتاجها الجسم وخلايا الجسم وبالتالي لأنها
+
+93
+00:07:59,940 --> 00:08:06,100
+أساسية فأي تغيير في تركيز هذه الـ lipids هيؤدي ذلك
+
+94
+00:08:06,100 --> 00:08:11,520
+إلى حدوث مشاكل، تمام؟عادة يحدث تقليد أو تقليد من
+
+95
+00:08:11,520 --> 00:08:16,640
+المستوى بسبب غلطيات في تنسيق التنسيق والتنسيق
+
+96
+00:08:16,640 --> 00:08:18,380
+والتنسيق والتنسيق والتنسيق والتنسيق والتنسيق
+
+97
+00:08:18,380 --> 00:08:19,800
+والتنسيق والتنسيق والتنسيق والتنسيق والتنسيق
+
+98
+00:08:19,800 --> 00:08:23,000
+والتنسيق والتنسيق والتنسيق والتنسيق والتنسيقهنا
+
+99
+00:08:23,000 --> 00:08:28,220
+بيحكيلي إن الزيادة أو المقصان في هذه الـ libids
+
+100
+00:08:28,220 --> 00:08:33,560
+إما بيكون السبب يعني شو أسباب إن الـ libids بتزيد
+
+101
+00:08:33,560 --> 00:08:38,680
+أو تنجس عند شخص معين إما يكون عندي مشكلة في الـ
+
+102
+00:08:38,680 --> 00:08:41,440
+synthesis في تصنيع هذه الـ libids أو بالـ
+
+103
+00:08:41,440 --> 00:08:46,240
+degradation، بتحطيمها أو بالـ Transporter نفسها أو
+
+104
+00:08:46,240 --> 00:08:50,500
+بنواقل الـ libids نفسها اللي هم الـ lipoprotein
+
+105
+00:08:51,040 --> 00:08:55,820
+ممكن يكون فيهم مشكلة فيهم خلل Increased or
+
+106
+00:08:55,820 --> 00:08:58,920
+decreased plasma lipoproteins are named
+
+107
+00:08:58,920 --> 00:09:03,520
+hyperlipoprotonemia وhypolipoprotonemia
+
+108
+00:09:03,520 --> 00:09:10,680
+respectivelyالارتفاع في نواقل الدهون يعني الارتفاع
+
+109
+00:09:10,680 --> 00:09:15,340
+في الـLiboprotein بنسميها Hyperliboprotonemia
+
+110
+00:09:15,340 --> 00:09:22,200
+والانخفاض في تركيز نواقل الدهون بنسميها
+
+111
+00:09:22,200 --> 00:09:28,320
+الـHyperliboprotonemia Hyperارتفاع وHyperانخفاض
+
+112
+00:09:28,320 --> 00:09:36,070
+Liboprotonemia يقصد فيها نواقل الدهونLipids as
+
+113
+00:09:36,070 --> 00:09:41,090
+biochemical markers of disease تعتبر الدهون علامة
+
+114
+00:09:41,090 --> 00:09:47,190
+كيميائية لحدوث مرض معين Clinical chemistry
+
+115
+00:09:47,190 --> 00:09:51,190
+laboratories offer many tests for lipid disorders
+
+116
+00:09:51,190 --> 00:09:57,690
+طبعا أوجدت المختبرات فحوصات بتشيك على وضع الدهون
+
+117
+00:09:57,690 --> 00:10:02,750
+في الجسم one of the most common tests is the lipid
+
+118
+00:10:02,750 --> 00:10:07,880
+profileواحد من أشهر الفحوصات الشائعة عندنا الـ
+
+119
+00:10:07,880 --> 00:10:11,880
+Libid Profile كلمة Profile حكينا لكم إياها قبل هيك
+
+120
+00:10:11,880 --> 00:10:16,240
+أو Libid Panel كلمة Panel معناها مجموعة كلمة
+
+121
+00:10:16,240 --> 00:10:20,600
+Profile معناها مجموعة لما أحكي لك في ال request في
+
+122
+00:10:20,600 --> 00:10:24,080
+الطلب Libid Profile يكتب لك الدكتور Libid Profile
+
+123
+00:10:24,080 --> 00:10:30,640
+يقصد فيها مجموعة الفحوصات الخاصة بالـ Libid وهم
+
+124
+00:10:30,640 --> 00:10:34,980
+أربع فحوصاتيعني لما الدكتور يكتب لنا فيه ال
+
+125
+00:10:34,980 --> 00:10:38,760
+request تبع المريض Lipid Profile يعني بده فحوصات
+
+126
+00:10:38,760 --> 00:10:45,480
+الدهون كلها وهم أربع فحوصات اللي هم أول فحص الـ
+
+127
+00:10:45,480 --> 00:10:50,400
+Triglyceride الدهون التلاتية تاني فحص الكلسترول
+
+128
+00:10:50,400 --> 00:10:57,680
+تالت فحص الـ HDL اللي هو فحص تركيزالـ high-density
+
+129
+00:10:57,680 --> 00:11:04,720
+lipoprotein والـ LDL الـ low-density lipoprotein
+
+130
+00:11:04,720 --> 00:11:09,100
+إذا بدنا نتفج مع بعض كلمة lipid profile معناها
+
+131
+00:11:09,100 --> 00:11:14,940
+فحوصات الدهون وهم أربع فحوصات زي ما كتبلكم this
+
+132
+00:11:14,940 --> 00:11:19,540
+panel of tests includes هذا الـ profile عبارة عن
+
+133
+00:11:19,540 --> 00:11:24,100
+measurement of قياس لـ triglycerides and
+
+134
+00:11:24,100 --> 00:11:30,310
+الكوليسترولهي فحسين وقياس الـ Low-density
+
+135
+00:11:30,310 --> 00:11:34,950
+lipoprotein cholesterol الـ LDL-C والـ High
+
+136
+00:11:34,950 --> 00:11:40,590
+-density lipoprotein cholesterol الـ HDL-C بدنا
+
+137
+00:11:40,590 --> 00:11:47,460
+نفهم إن الـ LDL والـ HDL هذي نواقل الدهونو بالأخص
+
+138
+00:11:47,460 --> 00:11:52,780
+هذه الـ lipoprotein هذه النواقل تنقل الكوليسترول
+
+139
+00:11:52,780 --> 00:11:58,580
+بشكل أكبر في ناس هتسألني طب تنقل الدهون التلاتية؟
+
+140
+00:11:58,580 --> 00:12:04,440
+نعم تنقل الدهون التلاتيةولكن هي بشكل أساسي بتنجلنا
+
+141
+00:12:04,440 --> 00:12:09,660
+الكوليسترول عشان هيك بيسموها HDL و LDL-C خاصة
+
+142
+00:12:09,660 --> 00:12:14,500
+بالكوليسترول مواقل بتحمل جواتها الكوليسترول
+
+143
+00:12:14,500 --> 00:12:19,700
+وبتنجله من البلازمة للخلاياالنتائج من تجارب
+
+144
+00:12:19,700 --> 00:12:24,380
+التجارب لهذه الليبادات تقدم ميجارات خطر للحصول على
+
+145
+00:12:24,380 --> 00:12:31,080
+مرض قلبي طبعا نتائج الفحوصات الأربعة هذه اللي احنا
+
+146
+00:12:31,080 --> 00:12:37,610
+عددناهمالنتائج هتحكم هل هذا الشخص هيكون عنده risk
+
+147
+00:12:37,610 --> 00:12:43,190
+factor لحدوث مرض الـ coronary heart disease أمراض
+
+148
+00:12:43,190 --> 00:12:47,970
+القلب والأوعية الدموية لأنه يا جماعة ارتفاع ال
+
+149
+00:12:47,970 --> 00:12:53,030
+libids ارتفاع الدهون في بلازمة الدم مرتبط ارتباط
+
+150
+00:12:53,030 --> 00:12:58,010
+وثيق بحدوث أمراض القلب والأوعية الدموية وتصلب
+
+151
+00:12:58,010 --> 00:13:03,830
+الشراينلأن الدهون لما بتزيد في البلازمة تترسب على
+
+152
+00:13:03,830 --> 00:13:09,210
+الأوردة والشرايين وبتسكر الشريان والوريد وبالتالي
+
+153
+00:13:09,210 --> 00:13:14,570
+بيبطل فيه تضفق للدم وبالتالي بيصير عندي أمراض الـ
+
+154
+00:13:14,570 --> 00:13:17,330
+cardiovascular disease أمراض القلب والأواعي
+
+155
+00:13:17,330 --> 00:13:21,910
+الدموية طبعا كيف الدهون بتسبب المرض هذا ميكانزم
+
+156
+00:13:21,910 --> 00:13:27,510
+كبير وحتخدومة بالنظري تمام؟بس بدنا نعرف إن ارتفاع
+
+157
+00:13:27,510 --> 00:13:31,590
+الدهون مرتبط ارتباط وسيق بحدوث أمراض القلب
+
+158
+00:13:31,590 --> 00:13:37,210
+والأوعية الدموية it is therefore clear that lipid
+
+159
+00:13:37,210 --> 00:13:40,050
+measurements should be made in all patients known
+
+160
+00:13:40,050 --> 00:13:43,690
+to have vesicular disease and induce at increased
+
+161
+00:13:43,690 --> 00:13:49,500
+riskيفضل إنه نعمل فحص الـ Lipid Profile فحوصات
+
+162
+00:13:49,500 --> 00:13:53,940
+الدمون للمرضى اللي أصلا هما بيعانوا من مشاكل في
+
+163
+00:13:53,940 --> 00:13:57,860
+القوية الدموية الـ Vascular Disease بين فترة و
+
+164
+00:13:57,860 --> 00:14:03,000
+فترة نشيك عليهم و نعملهم الـ Lipids Profile لإنهلو
+
+165
+00:14:03,000 --> 00:14:08,420
+زادت الدهون عندهم هتزيد الحالة عندهم وهتسكر
+
+166
+00:14:08,420 --> 00:14:12,920
+الشرايين والأوردة بشكل أكبر This plasma lipids
+
+167
+00:14:12,920 --> 00:14:15,960
+should be measured in the individuals with the
+
+168
+00:14:15,960 --> 00:14:20,000
+following هلجيت يا جماعة فحص هذه الجملة معناها أنه
+
+169
+00:14:20,000 --> 00:14:26,920
+فحص الـLipids Profile فحصات الدهون بتنطلب للحالات
+
+170
+00:14:26,920 --> 00:14:32,940
+التاليةأول حالة أي شخص عنده coronary heart disease
+
+171
+00:14:32,940 --> 00:14:36,700
+عنده مشاكل في القلب والأوعية الدموية لازم بين فترة
+
+172
+00:14:36,700 --> 00:14:40,500
+وفترة نعمله lipid zebrafine لأنه لو هذا الشخص
+
+173
+00:14:40,500 --> 00:14:45,840
+الدهون عنده زادت هتزيد عنده المشكلة هتزيد مشكلة
+
+174
+00:14:45,840 --> 00:14:49,340
+القلب والأوعية الدموية عنده الناس اللي عندها
+
+175
+00:14:49,340 --> 00:14:53,020
+cerebrovascular and peripheral vesicular disease
+
+176
+00:14:53,020 --> 00:14:56,730
+مشاكل في القلب والأوعية الدمويةتنين، a family
+
+177
+00:14:56,730 --> 00:15:01,230
+history of a premature coronary disease العائلة
+
+178
+00:15:01,230 --> 00:15:05,770
+اللي عندها تاريخ بمرض القلب والأوعي الدموية كتير
+
+179
+00:15:05,770 --> 00:15:11,330
+بنسأل ويراثيا في عائلات بصل الشاب على عمر التلاتين
+
+180
+00:15:11,330 --> 00:15:14,410
+أو الأربعين سنة بنصاب بأمراض القلب والأوعي
+
+181
+00:15:14,410 --> 00:15:18,770
+الدموية، هذا ويراثيا، وبالتالي أنا عارفة أن هذه
+
+182
+00:15:19,840 --> 00:15:24,720
+العائلة عندها بسن بصل الشاب سن الأربعين بيصير عنده
+
+183
+00:15:24,720 --> 00:15:28,400
+مشاكل في القلب وبالتالي أنا لازم أعمله Libids
+
+184
+00:15:28,400 --> 00:15:35,380
+Profile وأتابعه مبكرا من سن و هو صغير دايما نعمله
+
+185
+00:15:35,380 --> 00:15:42,500
+Libids Profile عشان نقلل من مضاعفات المرض نفسه،
+
+186
+00:15:42,500 --> 00:15:48,330
+تمام؟بنطلب الفحث للناس اللي عندها risk factor
+
+187
+00:15:48,330 --> 00:15:53,230
+للإصابة بأمراض القلب والأوعي الدموية الـ diabetes
+
+188
+00:15:53,230 --> 00:15:54,810
+mellitus والـ hypertension
+
+189
+00:15:57,300 --> 00:16:04,040
+اللي هما مرضى الضغط الـ hypertension ومرضى السكري
+
+190
+00:16:04,040 --> 00:16:08,440
+حكينا إنه من مضاعفات الضغط ومضاعفات السكري على
+
+191
+00:16:08,440 --> 00:16:12,060
+المدى اللي بعيد إنهم هيعانوا من أمراض بالقلب و
+
+192
+00:16:12,060 --> 00:16:15,220
+الأوعي الدموية فلازم دايما نعملهم الـ lipid
+
+193
+00:16:15,220 --> 00:16:19,020
+profile ال patients اللي بيكون عنده clinical
+
+194
+00:16:19,020 --> 00:16:23,660
+feature بيكون عنده أعراضارتفاع الدهون يعني من
+
+195
+00:16:23,660 --> 00:16:27,300
+الأعراض اللي أنا بشاهدها عليه بحكي والله عنده
+
+196
+00:16:27,300 --> 00:16:31,880
+ارتفاع الدهون في ال plasma فلازم نعمله فحص ال
+
+197
+00:16:31,880 --> 00:16:35,880
+limits profile patients whose plasma is seen to be
+
+198
+00:16:35,880 --> 00:16:40,080
+lipemic يعني لما انت تجي تفصل عينة المريض في كتير
+
+199
+00:16:40,080 --> 00:16:44,390
+ناس عندهم الدهون عالية بس ما بيشعروا فيهاوما
+
+200
+00:16:44,390 --> 00:16:48,830
+بيشعروا بأعراض أو مضاعفات وبالتالي من البلازمة
+
+201
+00:16:48,830 --> 00:16:53,350
+تبعتهم لما نفصل عيناتهم بنشوف البلازمة تبدو كأنها
+
+202
+00:16:53,350 --> 00:16:59,070
+milky زي الحليب معكرة تربيت تمام؟ بتكون lidemic
+
+203
+00:16:59,070 --> 00:16:59,870
+بلازمة
+
+204
+00:17:02,250 --> 00:17:07,130
+Positive risk factors هذه الحالات اللي بالجدول
+
+205
+00:17:07,130 --> 00:17:12,590
+الأزرق هذه الحالات لو انوجدت عند الشخص بيكون عنده
+
+206
+00:17:12,590 --> 00:17:17,910
+risk factor للإصابة بال coronary heart disease
+
+207
+00:17:17,910 --> 00:17:23,870
+بأمراض القلب والأوعية الدمويةالـ Age الأشخاص اللي
+
+208
+00:17:23,870 --> 00:17:27,730
+فوق سن الخمسة وأربعين من جهة ال man أو جهة ال
+
+209
+00:17:27,730 --> 00:17:31,790
+woman النساء العمرها أكتر من خمسة وخمسين يعني كل
+
+210
+00:17:31,790 --> 00:17:35,650
+ما الإنسان اتقدم بالعمر كل ما احتمال إصابته بأمراض
+
+211
+00:17:35,650 --> 00:17:39,910
+القلب والأوعي الدموية بتكون أكبر Family history of
+
+212
+00:17:39,910 --> 00:17:43,150
+a premature coronary heart disease الناس اللي
+
+213
+00:17:43,150 --> 00:17:47,570
+عندهم أصلا أمراض وراثية وبيصلوا سن معين وبيصير
+
+214
+00:17:47,570 --> 00:17:51,720
+عندهم المرضcurrent cigarette smoking الناس
+
+215
+00:17:51,720 --> 00:17:56,480
+المدخنين بشكل مستمر hypertension اللي عندهم ضغط
+
+216
+00:17:56,480 --> 00:18:02,320
+اللي عندهم تركيز الـ LDL كوليسترول concentration
+
+217
+00:18:02,320 --> 00:18:07,540
+أعلى من 160 milligram per deciliter بدنا نعرف يا
+
+218
+00:18:07,540 --> 00:18:13,800
+جماعة أن التركيز الطبيعي للـLDL كوليسترول أقل من
+
+219
+00:18:13,800 --> 00:18:18,830
+100 milligram per deciliter عند الإنسان الطبيعيلو
+
+220
+00:18:18,830 --> 00:18:23,790
+كان أكتر من 100 في عنده الشخص هيكون risk factor
+
+221
+00:18:23,790 --> 00:18:29,270
+للإصابة بأمراض القلب والأوعية الدموية برضه الـ LDL
+
+222
+00:18:29,270 --> 00:18:35,250
+لو كان أكتر من 130 أو زي ما حكتلكم أكتر من 100
+
+223
+00:18:36,090 --> 00:18:40,610
+بيكون هناك Risk Factor للإصابة بالـ Coronary Heart
+
+224
+00:18:40,610 --> 00:18:47,410
+Disease أو إذا كان الـ HDL أقل من 40 ميلي جرام per
+
+225
+00:18:47,410 --> 00:18:52,690
+ديسميتر الوضع الطبيعي إن الـ HDL عند الإنسان لازم
+
+226
+00:18:52,690 --> 00:18:58,730
+يكون أعلى من أكبر من 60 ميلي جرام per ديسميتر لو
+
+227
+00:18:58,730 --> 00:19:04,150
+كان أقل من 60، هيكون عندنا Risk Factor للإصابة
+
+228
+00:19:04,150 --> 00:19:08,360
+بأمراض القلبأيضًا الـ diabetes mellitus يعني يا
+
+229
+00:19:08,360 --> 00:19:14,120
+جماعة مش لأ الحفظ هذا الجدول بس بدنا نفهم أن هذه
+
+230
+00:19:14,120 --> 00:19:17,980
+حالات لو ان وجدت عند الشخص هيكون عنده risk factor
+
+231
+00:19:17,980 --> 00:19:23,120
+للإصابة بأمراض القلب والأوعية الدموية لكن لما نحكي
+
+232
+00:19:23,120 --> 00:19:27,900
+negative risk factors يعني لو ان وجدت هذه الأمور
+
+233
+00:19:27,900 --> 00:19:32,780
+مش هيصير عندنا أمراض لا بالقلب ولا بالأوعية
+
+234
+00:19:32,780 --> 00:19:37,820
+الدمويةإذا كان الـ HDL كوليسترول concentration
+
+235
+00:19:37,820 --> 00:19:41,720
+أعلى أو يساوي 60 milligram per deciliter هذا
+
+236
+00:19:41,720 --> 00:19:46,120
+ممتاز، هذا الإنسان الطبيعي أو إذا كان الـ LDL
+
+237
+00:19:46,120 --> 00:19:49,480
+كوليسترول أقل من 100 milligram per deciliter برضه
+
+238
+00:19:49,480 --> 00:19:54,580
+هذا محبب، هذا الـnormal range تمام؟ وبالتالي مش
+
+239
+00:19:54,580 --> 00:19:58,120
+هيصير عند الشخص أمراض لا بالقلب ولا بالأوعية
+
+240
+00:19:58,120 --> 00:20:05,160
+الدموية هذا الجدول مش للحفظ إنما للفهمهنبدأ في أول
+
+241
+00:20:05,160 --> 00:20:10,540
+نوع من أنواع الدهون اللي بتكون موجودة في الدم لـ
+
+242
+00:20:10,540 --> 00:20:15,280
+Triglycerides كتير بنسمع عنه الدهون التولاتية
+
+243
+00:20:15,280 --> 00:20:20,540
+glycerol-packed boon with fatty acid attached by
+
+244
+00:20:20,540 --> 00:20:26,590
+ester bondsالدهون التلاتية إيش تركيبها؟ تركيبها
+
+245
+00:20:26,590 --> 00:20:32,210
+three fatty acid تلت أحماض دهونية مرتبطة مع
+
+246
+00:20:32,210 --> 00:20:38,410
+إجليسرول بواسطة Easter bond هذه هي الدهون التلاتية
+
+247
+00:20:40,240 --> 00:20:47,740
+3 أحماض دهنية مربوطين بالجليسرول بواسطة Easter
+
+248
+00:20:47,740 --> 00:20:54,720
+bond طبعا الشكل مش مطلوب نحفظه ولا مطلوب نعرف
+
+249
+00:20:54,720 --> 00:21:00,150
+تركيبة الشكلالـ sources of triglycerides إيش مصادر
+
+250
+00:21:00,150 --> 00:21:04,170
+الدهون التلاتية؟يلها مصدرين يا جماعة exogenous
+
+251
+00:21:04,170 --> 00:21:08,770
+sources مصادر خارجية وindigenous sources مصادر
+
+252
+00:21:08,770 --> 00:21:14,270
+داخلية مصادر خارجية من الـ diet من الأكل يعني في
+
+253
+00:21:14,270 --> 00:21:21,570
+كتير أكلات بتكون مليانة دهون تلاتية إذا أكلنا تمام
+
+254
+00:21:22,450 --> 00:21:27,610
+إذن المصدر الخارجي للدهون التلاتية هي من أكل
+
+255
+00:21:27,610 --> 00:21:33,070
+الإنسان من الـ diet أما المصدر الداخلي لأ لـ
+
+256
+00:21:33,070 --> 00:21:38,110
+triglyceride من ال liver يعني المسئول عن تصنيع
+
+257
+00:21:38,110 --> 00:21:42,950
+الدهون التلاتية في داخل الجسم هو ال liver خارج
+
+258
+00:21:42,950 --> 00:21:46,850
+الجسم المصدر من ال diet طب بدنا نركز مع بعض هي
+
+259
+00:21:46,850 --> 00:21:52,710
+نعرفنا لـ triglycerideتركيبه واعرفنا مصادره بدي
+
+260
+00:21:52,710 --> 00:21:56,270
+أعرف لـ Triglyceride لما يسير في الدم الدهون
+
+261
+00:21:56,270 --> 00:22:00,690
+التلاتية مين بينجله للخلايا مش الخلايا أحيانا
+
+262
+00:22:00,690 --> 00:22:05,510
+تحتاج دهون تلاتية عشان تشتغل عشان تتكون كيف .. كيف
+
+263
+00:22:05,510 --> 00:22:08,890
+بتنتج للدهون التلاتية في الدم مش حاكينا بدها
+
+264
+00:22:08,890 --> 00:22:15,290
+lipoproteins بدها نواقل تكون هي بطبيعتها بروتينات
+
+265
+00:22:15,290 --> 00:22:21,820
+تنجلها من مكان لمكانتمام فانتبهوا معايا إذا كان
+
+266
+00:22:21,820 --> 00:22:27,420
+مصدر الدهون التلاتية من الأكل يعني المصدر
+
+267
+00:22:27,420 --> 00:22:32,260
+exogenous خارجي هلجيت أنت أكلت واجبة مليانة دهون
+
+268
+00:22:32,260 --> 00:22:38,000
+تلاتية وصلت هلجيت الدهون التلاتية عدم مين بيجي
+
+269
+00:22:38,000 --> 00:22:44,630
+ينجلها؟ بينجلها الكايلو مايكرونالكايلو مايكرون هو
+
+270
+00:22:44,630 --> 00:22:51,710
+نوع من أنواع نواقل الدهون وبشكل أثاثي بينجل لـ
+
+271
+00:22:51,710 --> 00:22:57,970
+triglyceride اللي بيكون مصدرها خارجي من الـ diet
+
+272
+00:22:59,650 --> 00:23:04,490
+إذن الـ «كايلومايكرون» هو الـ lipoprotein بينجلي
+
+273
+00:23:04,490 --> 00:23:11,450
+الـ triglyceride اللي مصدرها من الأكل تمام، هل جيت
+
+274
+00:23:11,450 --> 00:23:14,610
+حكينا إن الـ liver بيكوّن الـ triglyceride
+
+275
+00:23:14,610 --> 00:23:18,850
+وبالتالي بوصل الـ triglyceride على الدم، هل جيت
+
+276
+00:23:18,850 --> 00:23:24,690
+الـ triglyceride؟اللي مصدره من الكبد مين بينجله؟
+
+277
+00:23:24,690 --> 00:23:31,110
+بينجله معاقل آخر اسمه الـ VLDL الـ Very Low
+
+278
+00:23:31,110 --> 00:23:36,950
+Density Liboiprotein بينقل بشكل أساسي لـ
+
+279
+00:23:36,950 --> 00:23:42,110
+Triglyceride اللي بيكون مصدره من الكبد اللي اتصنع
+
+280
+00:23:42,110 --> 00:23:47,510
+فيه الكبد، تمام؟ إذا حسب المصدر تبع الـ
+
+281
+00:23:47,510 --> 00:23:54,320
+Triglycerideبيجي الليبو بروتين وبنجلو إذا كان
+
+282
+00:23:54,320 --> 00:23:58,320
+المصدر من الأكل مين بنجلو؟ الـ Chylomicron إذا كان
+
+283
+00:23:58,320 --> 00:24:02,580
+مصدر الدهون التلاتية من الكبد مين اللي هينجلو؟ الـ
+
+284
+00:24:02,580 --> 00:24:09,520
+VLDL لو سألناكم سؤال الـ VLDL الـ Very Low Density
+
+285
+00:24:09,520 --> 00:24:14,660
+Liboprotein هل هو ناقل فقط للـ Triglyceride اللي
+
+286
+00:24:14,660 --> 00:24:20,710
+مصدرها من الكبد؟ لأبيحمل كوليسترول ولكن بنسبة
+
+287
+00:24:20,710 --> 00:24:25,250
+قليلة يعني هو بينجل كوليسترول كمان ولكن مش بشكل
+
+288
+00:24:25,250 --> 00:24:30,150
+أساسي إنما هو بشكل أساسي مصمم للدهون التلاتية،
+
+289
+00:24:30,150 --> 00:24:33,450
+تمام؟
+
+290
+00:24:33,450 --> 00:24:37,870
+Triglycerides، serum triglycerides measurements
+
+291
+00:24:37,870 --> 00:24:42,790
+are done for the following clinical reasons هلجيت
+
+292
+00:24:42,790 --> 00:24:48,740
+يا جماعة؟ارتفاع لـ Triglycerides في بلازمة الدم
+
+293
+00:24:48,740 --> 00:24:55,400
+يسبب Pancreatitis يسبب التهاب في البنكرياز لأن
+
+294
+00:24:55,400 --> 00:24:59,600
+الدهون لما ترتفع في البلازمة في الدم وبيزيد
+
+295
+00:24:59,600 --> 00:25:05,300
+تركيزها عن الـ Range المسموح تبدأ تترثب على أعضاء
+
+296
+00:25:05,300 --> 00:25:10,340
+وخلايا الجثم فتبدأ الدهون التولاتية تترثب على
+
+297
+00:25:10,340 --> 00:25:14,940
+البنكرياز وبتعمل فيه التهابإذن الـHyper
+
+298
+00:25:14,940 --> 00:25:20,540
+-Triglyceridemia يعني التهاب يعني ارتفاع
+
+299
+00:25:20,540 --> 00:25:25,760
+للـTriglyceride في الدم Increases the risk for
+
+300
+00:25:25,760 --> 00:25:33,060
+pancreatitis إذن يزيد من احتمالية الإصابة بالتهاب
+
+301
+00:25:33,060 --> 00:25:37,260
+البانكرياس يعني أغلب اللي عندهم ارتفاع في الدهون
+
+302
+00:25:37,260 --> 00:25:41,040
+التلاتية بشكل هائل بيكون عندهم التهاب في
+
+303
+00:25:41,040 --> 00:25:45,200
+البانكرياسلأن الدهون التلاتية بتترثب على الـ
+
+304
+00:25:45,200 --> 00:25:51,260
+pancreas الـ hyper triglyceridemia ارتفاع لـ
+
+305
+00:25:51,260 --> 00:25:56,700
+triglyceride في الدم is associated مربوط with the
+
+306
+00:25:56,700 --> 00:26:01,160
+following clinical findings مربوط بـ clinical
+
+307
+00:26:01,160 --> 00:26:06,460
+feature بيحكوا عنها بأعراض تمام؟ يعني الناس اللي
+
+308
+00:26:06,460 --> 00:26:10,020
+بيكون عندهم ارتفاع في الدهون التلاتية بيكون عندهم
+
+309
+00:26:10,020 --> 00:26:15,650
+أعراضمش شرط تنطبق عليهم كل الأعراض أول شغلة الـ
+
+310
+00:26:15,650 --> 00:26:21,230
+Eruptive Exanthoma الـ Exanthoma يا جماعة زي
+
+311
+00:26:21,230 --> 00:26:26,590
+الرسمة اللي فوق الأولى هي عبارة عن تقرحات على سطح
+
+312
+00:26:26,590 --> 00:26:33,680
+ال skin على سطح الجلد أو بيحكوا عنهانتوئات تقرحات
+
+313
+00:26:33,680 --> 00:26:38,980
+أو نتوئات على ال skin surface على سطح الجلد تظهر
+
+314
+00:26:38,980 --> 00:26:44,780
+في في في كل ممااطق الجسم تظهر في القدم بالإيد على
+
+315
+00:26:44,780 --> 00:26:50,250
+الرجبةعالوجه، هذه التقرحات بتظهر في كل مكان، إيش
+
+316
+00:26:50,250 --> 00:26:54,190
+سببها؟ اتفجنا، نتيجة ارتفاع الدهون التلاتية في
+
+317
+00:26:54,190 --> 00:26:58,270
+البلازمة، تبدأ الدهون التلاتية تترثب على أعضاء
+
+318
+00:26:58,270 --> 00:27:02,030
+الجسم المختلفة، ترثبت على الـPancreas، تبدأ تترثب
+
+319
+00:27:02,030 --> 00:27:07,350
+على الـSkin، تطلع على الـSkin، وبالتالي تعمل
+
+320
+00:27:07,350 --> 00:27:14,430
+تقرحات ونتوئات،Libemia Retinalis أيضًا ارتفاع
+
+321
+00:27:14,430 --> 00:27:19,470
+الدهون التلاتية في البلازمة بتخلي قرنية العين
+
+322
+00:27:19,470 --> 00:27:23,970
+لـLibemia Retinalis معنى الكلام لو شفت الصورة
+
+323
+00:27:23,970 --> 00:27:28,730
+التانية شفت الشرايين والأوردة اللي بتغذ الرتنة
+
+324
+00:27:28,730 --> 00:27:32,720
+اللي بتغذ قرنية العينالوفترض يكون لونها أحمر، مش
+
+325
+00:27:32,720 --> 00:27:36,420
+بيمشي فيها الدم، ولكن نتيجة لارتفاع الدهون
+
+326
+00:27:36,420 --> 00:27:41,100
+التلاتية في الـ Plasma، تبدأ الدهون التلاتية تترثب
+
+327
+00:27:41,100 --> 00:27:46,900
+جوات الأوعية والشرين، تمام؟ وطبعا الدهون إيش بده
+
+328
+00:27:46,900 --> 00:27:51,640
+يكون لونها؟ زي الـ Milky Color، لون الحليب بالظبط
+
+329
+00:27:52,560 --> 00:27:57,380
+تبدو وكأنها Milky Appearance زي الحليب زي ما احنا
+
+330
+00:27:57,380 --> 00:28:02,900
+شايفين مش أوردة و شريين حمرة هذا نتيجة ترسب الدهون
+
+331
+00:28:02,900 --> 00:28:08,240
+التلاتية في الأوردة والشريين المغذية لقرانية العين
+
+332
+00:28:08,240 --> 00:28:13,260
+هذه بنسميها Lipemia Retinalis برضه من الأعراض ممكن
+
+333
+00:28:13,260 --> 00:28:17,860
+يصير عنا Hepatomegaly وSplenomegaly يعني تدخم في
+
+334
+00:28:17,860 --> 00:28:22,920
+ال liver و في ال spleenأيضًا Depressed الـ HDL
+
+335
+00:28:22,920 --> 00:28:28,800
+ارتفاع الدهون التلاتية بعمل depression بعمل تفبيط
+
+336
+00:28:28,800 --> 00:28:36,320
+للـ HDL أي ينقص من مستوى الـ HDL كوليسترالوهذا مش
+
+337
+00:28:36,320 --> 00:28:42,260
+كويس وحنشوف لقدام لما ناخد الـ HDL ونفهم كويس إيش
+
+338
+00:28:42,260 --> 00:28:46,040
+دوره إذا نرتفع الدهون التلاتية بيعمل depressed
+
+339
+00:28:46,040 --> 00:28:51,760
+بيخفض من الـ HDL كوليسترال in characterizing risk
+
+340
+00:28:51,760 --> 00:28:56,340
+ofcardiovascular disease أكيد اللي عنده ارتفاع في
+
+341
+00:28:56,340 --> 00:29:00,160
+الدهون التلاتية بيكون عنده احتمال للاصابة بأمراض
+
+342
+00:29:00,160 --> 00:29:04,200
+القلب والأوعية الدموية for the estimation of LDL
+
+343
+00:29:04,200 --> 00:29:08,640
+cholesterol using the Friedwald equation إذا بدك
+
+344
+00:29:08,640 --> 00:29:12,540
+تحسب تركيز الـ LDL تستخدم معادلة هذه في نهاية
+
+345
+00:29:12,540 --> 00:29:14,220
+المحاضرة هنفهمها
+
+346
+00:29:16,450 --> 00:29:21,490
+خلّونا يا جماعة نبدأ بالأهم إيجاني شخص مكتوب في
+
+347
+00:29:21,490 --> 00:29:25,890
+الـrequest تبعه try a glyceride test يعني فحص ضغون
+
+348
+00:29:25,890 --> 00:29:30,690
+طولاتية إيش العينة اللي بدي أسحبها منه؟ العينة إما
+
+349
+00:29:30,690 --> 00:29:34,150
+Serum أو بلازمة ولو بدي أسحب بلازمة نوع
+
+350
+00:29:34,150 --> 00:29:38,850
+الـAnticoagulant Editablecertain anticoagulants
+
+351
+00:29:38,850 --> 00:29:44,450
+لكن الـ anticoagulants الأخرى زي الفلورايد الستريت
+
+352
+00:29:44,450 --> 00:29:51,850
+الأجزاليت هذه ممنوعة بتاتا لأن لو أنا جمعت عينة
+
+353
+00:29:51,850 --> 00:29:55,350
+الدم في هذه الـ anticoagulant في الفلورايد أو
+
+354
+00:29:55,350 --> 00:30:02,600
+الستريت أو الأجزاليت إيش هيصير؟ هيؤدي ذلك إلىعمل
+
+355
+00:30:02,600 --> 00:30:08,160
+cause large shifts of water from the red blood
+
+356
+00:30:08,160 --> 00:30:14,320
+cell to بلازمه هتصير تطلع الميه اللي موجوده جواه
+
+357
+00:30:14,320 --> 00:30:21,500
+الـ RBC هتطلع بكميات كبيرة و تروح على بلازمه الدم
+
+358
+00:30:21,500 --> 00:30:26,260
+طبعا في بلازمه الدم عند السكر و عند البروتينات و
+
+359
+00:30:26,260 --> 00:30:30,080
+عند الـ lipids بأنواعها و مواقع الـ lipids كلها
+
+360
+00:30:30,080 --> 00:30:33,740
+موجودة في البلازمهفلما الميّه يسيرلها الـ Shift
+
+361
+00:30:33,740 --> 00:30:41,030
+تطلع من الـ RBCsوتروح ليه على البلازمة؟ إيش هيصير
+
+362
+00:30:41,030 --> 00:30:45,710
+في مكونات البلازمة؟ هتتخفف وبالتالي الـLimits اللي
+
+363
+00:30:45,710 --> 00:30:50,290
+موجودة في البلازمة، البروتينات كل هذا هيتخفف ويجيل
+
+364
+00:30:50,290 --> 00:30:55,150
+تركيزه بشكل خاطئ which result in the dilution of
+
+365
+00:30:55,150 --> 00:30:59,590
+the plasma components تقريبا 10% من الدهون
+
+366
+00:30:59,590 --> 00:31:06,910
+التلاتية هيتخففإذن، ليش ممنوع أي Anticoagulant فقط
+
+367
+00:31:06,910 --> 00:31:10,110
+المسموح في الـ Edeta؟ لأنه لو استخدمت هذه الـ
+
+368
+00:31:10,110 --> 00:31:14,430
+Anticoagulant تعمل shifting للـ water بتطلع الميّه
+
+369
+00:31:14,430 --> 00:31:18,450
+الموجودة في خلايا الدم الحمرة وبتخليها تروح على
+
+370
+00:31:18,450 --> 00:31:21,730
+البلازمة وبالتالي، هذه الميّه الزيادتها في
+
+371
+00:31:21,730 --> 00:31:26,330
+البلازمة هتخفف الـ component مكونات البلازمة بما
+
+372
+00:31:26,330 --> 00:31:30,550
+فيها الـ lipids بما فيها الدهون التلاتية هيجل
+
+373
+00:31:30,550 --> 00:31:37,460
+تركيزها عن الطبيعيلازم فحص الدهون التلاتية تكون
+
+374
+00:31:37,460 --> 00:31:43,220
+صايم من 12 ل 16 ساعة لإن اتفجنا الدهون التلاتية
+
+375
+00:31:43,220 --> 00:31:49,100
+مصادرها خارجية من الأكل فإنت لو أكلت أكل مش هعرف
+
+376
+00:31:49,100 --> 00:31:52,640
+أفحص لك فحص الدهون التلاتية هلاجي الدهون التلاتية
+
+377
+00:31:52,640 --> 00:31:56,940
+مولعة عندك تمام لإن انت فعليا بتكون ماكل أكلات
+
+378
+00:31:56,940 --> 00:32:02,590
+فيها دهون تلاتية فلازم نكون صايمينSamples drawn
+
+379
+00:32:02,590 --> 00:32:05,810
+from non-fasting patients are not suitable for
+
+380
+00:32:05,810 --> 00:32:10,670
+analysis أي عينة بتتاخد من مريض مش صايم هذه العينة
+
+381
+00:32:10,670 --> 00:32:17,150
+مش مقبولة ما بدناياها مش مناسبة للفحص لأنه بما أنه
+
+382
+00:32:17,150 --> 00:32:22,110
+non-fast زي ما حكيتلكم مش صايم يعني بياكل والأكل
+
+383
+00:32:22,110 --> 00:32:25,870
+هيكون في دهون تلاتية وبالتالي لو فحصلوا الدهون
+
+384
+00:32:25,870 --> 00:32:31,150
+التلاتية هتكون عالية كتيرطب هل عالية كتير لإنه
+
+385
+00:32:31,150 --> 00:32:35,930
+ماكل أكلات فيها دهون تلاتية ولا عالية كتير لإنه
+
+386
+00:32:35,930 --> 00:32:40,830
+عنده مشاكل أصلا في الدهون التلاتية في الجسم مش
+
+387
+00:32:40,830 --> 00:32:46,370
+هقدر أميز since elevated لـ triglyceride levels
+
+388
+00:32:47,690 --> 00:32:52,310
+caused by normal absorption of food ارتفاع التاج
+
+389
+00:32:52,310 --> 00:32:57,770
+عنده هيكون بسبب الأكل cannot be distinguished مش
+
+390
+00:32:57,770 --> 00:33:04,430
+هقدر اميزه عن الارتفاع اللي بيكون سببه أصلا حالة
+
+391
+00:33:04,430 --> 00:33:08,390
+مرضية lipid metabolism or inborn error of
+
+392
+00:33:08,390 --> 00:33:12,950
+metabolism تمام؟عشان هيك لازم نكون صايمين تخزين
+
+393
+00:33:12,950 --> 00:33:16,330
+السيرام و البلازمة في ال room temperature مدة
+
+394
+00:33:16,330 --> 00:33:20,050
+يومين في التلاجة بتظلها العين السبع أيام في ال
+
+395
+00:33:20,050 --> 00:33:26,110
+freezer ممكن أخزنها لمدة سنة كاملةEnzymatic method
+
+396
+00:33:26,110 --> 00:33:33,050
+طريقة شغل فحث لـ Triglyceride كتات لـ Triglyceride
+
+397
+00:33:33,050 --> 00:33:37,610
+مبدأها Enzymatic method أغلبها بيشتغل بطريقة
+
+398
+00:33:37,610 --> 00:33:43,750
+الانزيمات هاي ال slide اللي أمامنا هي يعني هنشرحها
+
+399
+00:33:43,750 --> 00:33:49,730
+ولكن بشكل مختصر وأفضل من هيك بال slide اللي بعيدها
+
+400
+00:33:49,730 --> 00:33:50,250
+تمام؟
+
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/a3GO5ndJhG8.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/a3GO5ndJhG8.srt
new file mode 100644
index 0000000000000000000000000000000000000000..54fd32f4b17264d600d791677c98a714e9b49d18
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/a3GO5ndJhG8.srt
@@ -0,0 +1,1344 @@
+1
+00:00:00,000 --> 00:00:05,140
+بدنا هالجهة نبدأ بفحص الـOGTT اختصار لـ Oral
+
+2
+00:00:05,140 --> 00:00:11,800
+Glucose Tolerance Test فكرة الفحص بكل بساطة فكرة
+
+3
+00:00:11,800 --> 00:00:17,060
+فحص الـ OGTT Oral Glucose من اسمه إنه بيجيك شخص بدي
+
+4
+00:00:17,060 --> 00:00:22,590
+يعمل هذا الفحص بدي يعمل فحص الـ OGTT بروح بقى أعطيه
+
+5
+00:00:22,590 --> 00:00:29,250
+قطعة سكر أو سكر مدوب بمية هالجيت بنشوف كيف وبيشربه
+
+6
+00:00:29,250 --> 00:00:33,090
+هالجيت لو جسمه طبيعي الوضع الطبيعي أنت أكلت شغل
+
+7
+00:00:33,090 --> 00:00:38,120
+فيه سكر معناه السكر في الدم عندك هيزيد نتيجة زيادة
+
+8
+00:00:38,120 --> 00:00:42,460
+السكر في الدم الإنسولين بتحسس لهذا السكر بيبقى
+
+9
+00:00:42,460 --> 00:00:47,460
+يطلع الإنسولين على الدم وبيبدأ الإنسولين ياخد هذا
+
+10
+00:00:47,460 --> 00:00:52,700
+السكر الموجود في الدم ويبدأ يساوي فيه، يدخله جواه
+
+11
+00:00:52,700 --> 00:00:57,660
+الخلايا عشان دور الإنسولين بيبَخَفّض مستوى السكر
+
+12
+00:00:57,660 --> 00:01:03,510
+الموجود في الدم هذا بكل بساطة اللي بيصير هذا أنت
+
+13
+00:01:03,510 --> 00:01:09,710
+إنسان طبيعي استطاع جسمك يتعامل كلمة يتعامل هنا
+
+14
+00:01:09,710 --> 00:01:14,510
+معناها tolerance يتحمل يتعامل لأن جسمك طبيعي
+
+15
+00:01:14,510 --> 00:01:20,650
+استطاع جسمك يتعامل مع جرعة السكر اللي أنا أعطيتك
+
+16
+00:01:20,650 --> 00:01:25,980
+إياها. اهتمام؟ على سبيل المثال، لو جينا لإنسان عنده
+
+17
+00:01:25,980 --> 00:01:30,500
+مشاكل بالإنسولين وعنده مشاكل بهرمون الإنسولين،
+
+18
+00:01:30,500 --> 00:01:35,320
+أعطيته جرعة سكر، شربها، أكلها، أيا كان، قطعة سكر،
+
+19
+00:01:35,320 --> 00:01:39,810
+سكر في الدم هيزيد عنده مشكلة بالإنسولين هرمون
+
+20
+00:01:39,810 --> 00:01:44,050
+الإنسولين لم يتم إفرازه وبالتالي إيش هيصير في
+
+21
+00:01:44,050 --> 00:01:50,270
+السكر؟ هيظل عالي معناه بنستنتج إن جسم هذا الشخص
+
+22
+00:01:50,270 --> 00:01:54,630
+إنتولرانس كلمة intolerance عكس tolerance
+
+23
+00:01:54,630 --> 00:02:00,110
+intolerance معناه لم يتعامل مع جرعة السكر اللي أنا
+
+24
+00:02:00,110 --> 00:02:07,180
+أعطيته إياها. إذن بشكل مبسط الإنسان الطبيعي بيقدر
+
+25
+00:02:07,180 --> 00:02:11,340
+يتعامل مع جرعة السكر اللي أنا بعطيه إياها
+
+26
+00:02:11,340 --> 00:02:15,900
+Tolerance، يتحمل لإنه عنده إنسولين والإنسولين هيخفض
+
+27
+00:02:15,900 --> 00:02:19,900
+السكر عنده في الدم لكن الإنسان الثاني عنده problem،
+
+28
+00:02:19,900 --> 00:02:25,320
+عنده مشاكل في الإنسولين لو أنا أعطيته جرعة سكر جسمه
+
+29
+00:02:25,320 --> 00:02:30,550
+Intolerance. Intolerance معناه لا يستطيع أن يتعامل
+
+30
+00:02:30,550 --> 00:02:34,590
+مع جرعة السكر اللي أنا أعطيته إياها لإنه بكل بساطة
+
+31
+00:02:34,590 --> 00:02:40,390
+الإنسولين فيه مشاكل، تمام؟ هذه فكرة الفحص. On a
+
+32
+00:02:40,390 --> 00:02:45,270
+standard oral glucose dose لما أنا أعطيك جرعة من
+
+33
+00:02:45,270 --> 00:02:50,650
+الجلوكوز، طبعا الجلوكوز محلول، بيتم تناوله عن
+
+34
+00:02:50,650 --> 00:02:55,750
+طريق الفم، تمام؟ بنشربه شرب أو بتأكله جرعة من السكر
+
+35
+00:02:56,390 --> 00:03:01,450
+التجارب عن تجارب الجلوكوز والتمثيل الغذائي لتجارب
+
+36
+00:03:01,450 --> 00:03:06,270
+الجلوكوز يجب أن تكون هناك قدرة على التحمل في ملاحظة
+
+37
+00:03:06,270 --> 00:03:11,770
+الانتظام الطبيعي والعودة هنا حيصير في استجابة لجسمك جسمك
+
+38
+00:03:11,770 --> 00:03:17,230
+هينتظم و هيعمل عمليات لهذا الجلوكوز هيطلع الإنسولين
+
+39
+00:03:17,960 --> 00:03:23,640
+هذا الإنسولين بالأول السكر ارتفع الإنسولين هيجي
+
+40
+00:03:23,640 --> 00:03:28,600
+يدخل السكر على الخلايا وبالتالي يرجع return برجع
+
+41
+00:03:28,600 --> 00:03:34,020
+السكر لوضعه الطبيعي تمام؟ إذا جسمك tolerant، اتحمل
+
+42
+00:03:34,020 --> 00:03:39,440
+whereas على سبيل العكس والنقيض abnormal and
+
+43
+00:03:39,440 --> 00:03:43,700
+improper glucose metabolism is termed glucose
+
+44
+00:03:43,700 --> 00:03:49,100
+intolerance. الثاني عنده مشكلة في العمليات الخاصة
+
+45
+00:03:49,100 --> 00:03:54,160
+بالجلوكوز مشكلة أنه ما فيش إنسولين مثلا يخفض مستوى
+
+46
+00:03:54,160 --> 00:03:59,000
+السكر عنده وبالتالي جسمه intolerance مش قادر
+
+47
+00:03:59,000 --> 00:04:03,740
+يتعامل مع جرعة السكر اللي أنا أعطيته إياها. هذه فكرة
+
+48
+00:04:03,740 --> 00:04:08,460
+فحص الـ Oral Glucose Tolerance Test هل جسمك بيقدر
+
+49
+00:04:08,460 --> 00:04:13,920
+يتعامل أو لا يستطيع أن يتعامل مع جرعة السكر اللي
+
+50
+00:04:13,920 --> 00:04:18,890
+تم إعطاؤك إياها، تمام؟ This is used to diagnose
+
+51
+00:04:18,890 --> 00:04:24,010
+diseases where the glucose metabolism is impaired
+
+52
+00:04:24,010 --> 00:04:29,410
+as in diabetes mellitus. فحص الـ OGTT مثل فحص الـ
+
+53
+00:04:29,410 --> 00:04:34,690
+fasting blood sugar يستخدم بغرض الـ diagnosis بغرض
+
+54
+00:04:34,690 --> 00:04:41,660
+التشخيص أقول هل عندك مرض سكري أم سليم، إذا الهدف
+
+55
+00:04:41,660 --> 00:04:45,820
+منه يعني أنا بقدر أعمل فحص الـ OGTT، أي شخص بقدر
+
+56
+00:04:45,820 --> 00:04:49,480
+يعمل فحص الـ OGTT عشان يعرف عنده سكري ولا لأ،
+
+57
+00:04:49,480 --> 00:04:54,480
+تمام؟ تمام. الـ Oral glucose tolerance test هذا
+
+58
+00:04:54,480 --> 00:05:00,340
+الفحص has been widely used as the golden standard
+
+59
+00:05:00,340 --> 00:05:05,160
+for diagnosis of diabetes mellitus in clinically
+
+60
+00:05:05,160 --> 00:05:11,300
+doubtful cases. هذا الفحص بشكل منتشر وواسع هو الـ
+
+61
+00:05:11,300 --> 00:05:16,120
+golden standard هو الفحص المثالي الذهبي من أجل
+
+62
+00:05:16,120 --> 00:05:21,460
+التشخيص من أجل إني أحكي عن شخص سليم ولا عنده مرض
+
+63
+00:05:21,460 --> 00:05:27,320
+سكري خاصة في الحالات الـ doubtful cases الحالات
+
+64
+00:05:27,320 --> 00:05:31,680
+المشكوك في أمرها اللي لو أنا عملتلها fasting blood
+
+65
+00:05:31,680 --> 00:05:37,120
+sugar بتكونش واضحة كثير عنده سكري ولا لأ فبنطلب له
+
+66
+00:05:37,120 --> 00:05:41,240
+الـ OGTT تمام؟ في الحالات المشكوك في أمرها
+
+67
+00:05:41,240 --> 00:05:44,620
+والحالات العادية اللي بدي أعرف عنده سكر ولا لأ
+
+68
+00:05:44,620 --> 00:05:51,500
+إذاً هذا الفحص، لا التشخيص. Lately, throughout the use of
+
+69
+00:05:51,500 --> 00:05:57,860
+OGTT in primary care has been questioned for
+
+70
+00:05:57,860 --> 00:06:03,140
+several reasons. طبعا فحص الـ OGTT فحص بيعمله في
+
+71
+00:06:03,140 --> 00:06:07,720
+الرعاية الأولية وفي المستشفيات لعدة أسباب، بينطلب
+
+72
+00:06:07,720 --> 00:06:13,590
+لعدة أسباب. It has low reproducibility and is very
+
+73
+00:06:13,590 --> 00:06:17,910
+expensive. للأسف هذا الفحص مع إنه الفحص الذهبي من
+
+74
+00:06:17,910 --> 00:06:22,390
+أجل التشخيص هل عندك سكري ولا لأ إلا إنه فيه عيوب
+
+75
+00:06:22,390 --> 00:06:27,110
+إنه كثير غالي مش يعني مش كتير كتير غالي إنه لو
+
+76
+00:06:27,110 --> 00:06:31,370
+بدنا نيجي نحكي فحص السكر فحص السكر هذا فحص روتيني
+
+77
+00:06:31,630 --> 00:06:36,110
+يعني يفترض يكون سعره ما يزيدش عن 10 شيكل لكن لما
+
+78
+00:06:36,110 --> 00:06:40,450
+أبدأ أحكي لك أعمل فحص السكر بـ 20 أو بـ 30 زي فحص
+
+79
+00:06:40,450 --> 00:06:44,110
+الـ OGTT، هذه مشكلة إذن المشكلة الأساسية بهذا
+
+80
+00:06:44,110 --> 00:06:49,370
+الفحص إنه كثير غالي ومش دائماً بنطلبه. However, for
+
+81
+00:06:49,370 --> 00:06:53,330
+the detection of diabetes in a pregnant woman is
+
+82
+00:06:53,330 --> 00:06:59,390
+still recommended. ما زال هذا الفحص اللي بيوصف فيه
+
+83
+00:06:59,390 --> 00:07:04,870
+إنه ينعمل للستات الحوامل اللي بيشكوا إنه عندهم سكر
+
+84
+00:07:04,870 --> 00:07:10,010
+حمل. وبيني وبينكم في المستشفيات هذا الفحص ما بينعملش
+
+85
+00:07:10,010 --> 00:07:14,530
+يعني أنا لو شك عندي سكر ولا لأ بروح المستشفى بعمل
+
+86
+00:07:14,530 --> 00:07:18,990
+فحص الـ fasting blood sugar العادي تمام؟ بصوم تمام
+
+87
+00:07:18,990 --> 00:07:24,050
+ساعات و بروح أعمله. بس فحص الـ OGTT هنا بينعمل فقط
+
+88
+00:07:24,050 --> 00:07:29,490
+بعيادات الوكالة للستات الحوامل اللي شاكين في عندها
+
+89
+00:07:29,490 --> 00:07:35,380
+سكر حمل. هل جَاءَ الشخص اللي بدي أعمل له هذا الفحص سواء
+
+90
+00:07:35,380 --> 00:07:39,880
+ست حامل وشاكين عندها سكري أو الشخص العادي بدي أشوف
+
+91
+00:07:39,880 --> 00:07:44,100
+عنده سكر ولا لأ أو طفل انولد شاكين فيه عنده سكر ولا
+
+92
+00:07:44,100 --> 00:07:48,320
+لأ لازم يكون فيه preparation فيه تحضير للمريض أول
+
+93
+00:07:48,320 --> 00:07:53,380
+شيء ممنوع تعمل أي activity أي نشاط أو جهد. Don't
+
+94
+00:07:53,380 --> 00:07:58,860
+smoke. ممنوع التدخين أو أي exercise يكون نشاطات
+
+95
+00:07:59,450 --> 00:08:05,610
+تعتمد مجهود وصعبة، ممنوع تعملها لمدة 8 ساعات قبل
+
+96
+00:08:05,610 --> 00:08:10,110
+إجراء الفحص أو خلال وانت بتعمل الفحص. إذا ممنوع
+
+97
+00:08:10,110 --> 00:08:14,810
+التدخين، ممنوع الـ activity، ممنوع الـ exercise لمدة
+
+98
+00:08:14,810 --> 00:08:18,990
+8 ساعات قبل إجراء الفحص يعني قبل 8 ساعات من إجراءك
+
+99
+00:08:18,990 --> 00:08:24,950
+للفحص، بدك تمتنع عن هذه الأشياء. تمام؟ برضه هذا
+
+100
+00:08:24,950 --> 00:08:29,010
+الفحص يعني أنا عارفة إن الأسبوع اللي جاي بدي أروح
+
+101
+00:08:29,010 --> 00:08:35,010
+أعمل فحص الـ OGTT لازم أحضر نفسي قبل ثلاثة أيام من
+
+102
+00:08:35,010 --> 00:08:40,050
+عمل الفحص لازم هذه الثلاثة أيام أكل فيها
+
+103
+00:08:40,050 --> 00:08:46,010
+carbohydrate كتير أغذي حالي شوية، تمام؟ Diet، eat
+
+104
+00:08:46,010 --> 00:08:51,850
+a high carbohydrate diet. بدك تاكل أكلات مليئة بالـ
+
+105
+00:08:51,850 --> 00:08:58,380
+carbohydrate. بدك تاكل تقريباً يكون فيه 150
+
+106
+00:08:58,380 --> 00:09:03,580
+جرام يومياً بدي يكون الأكل تبعك فيه Carbohydrate
+
+107
+00:09:03,580 --> 00:09:09,400
+أكثر من 150 جرام يومياً لمدة ثلاثة أيام، إذا قبل ما
+
+108
+00:09:09,400 --> 00:09:14,020
+تعمل الفحص بثلاثة أيام، بدك تغذي حالك، تاكل أكلات
+
+109
+00:09:14,020 --> 00:09:19,560
+مليئة بالـ Carbohydrate. Then وبعد هيك بعد الثلاثة
+
+110
+00:09:19,560 --> 00:09:23,600
+أيام اليوم الرابع بدك تعمل الفحص. بعد هيك بدك تبدأ
+
+111
+00:09:23,600 --> 00:09:29,740
+تصوم. Then fast. لازم قبل ما أجري هذا الفحص أصوم من
+
+112
+00:09:29,740 --> 00:09:36,100
+عشرة إلى اثنتي عشرة ساعة. 10، 11، 12، في ناس بتصوم ثمانية
+
+113
+00:09:36,100 --> 00:09:43,540
+برضه صح. نصوم 10 إلى 12 ساعة قبل إجراء الفحص وممنوع
+
+114
+00:09:43,540 --> 00:09:47,920
+في فترة الصوم تشرب قهوة أو تشرب.. الأشخاص طبعاً
+
+115
+00:09:47,920 --> 00:09:53,140
+اللي بيشربوا كحول لمدة 8 ساعات قبل إجراء الفحص فقط
+
+116
+00:09:53,140 --> 00:09:58,920
+الأشياء المسموحة فيها أشربها وأنا صائمة. المياه بتصومي
+
+117
+00:09:58,920 --> 00:10:02,000
+عن كل شيء إلا المياه عادي المياه مسموح لك في هذا
+
+118
+00:10:02,000 --> 00:10:06,980
+الفحص تشربيه. تمام؟ أي drugs أي أدوية أي
+
+119
+00:10:06,980 --> 00:10:12,400
+medication أنت بتاخذه؟ لازم تخبر أخصائي التحليل
+
+120
+00:10:12,400 --> 00:10:18,180
+إنك بتاخد علاج كذا كذا لأنه بيخاف هذا العلاج يأثر
+
+121
+00:10:18,180 --> 00:10:23,420
+على نتيجة الفحص. Drug medicines inform the person
+
+122
+00:10:23,420 --> 00:10:27,240
+performing the test to omit any medication listed
+
+123
+00:10:27,240 --> 00:10:31,900
+يقول لنا إيش بياخد أدوية. As undertaking this drug
+
+124
+00:10:31,900 --> 00:10:35,540
+the test result may differ. ممكن وإنت ممكن هذه
+
+125
+00:10:35,540 --> 00:10:39,810
+الأدوية تأثر على نتيجة الفحص. الـ Contraceptive حبوب
+
+126
+00:10:39,810 --> 00:10:44,850
+منع الحمل to be stopped. لازم نوقفها one cycle
+
+127
+00:10:44,850 --> 00:10:50,250
+before the performance of the OGTT. إذن حبوب منع
+
+128
+00:10:50,250 --> 00:10:54,630
+الحمل برضه بتأثر على هذا الفحص وأدوية أخرى بتأثر
+
+129
+00:10:54,630 --> 00:10:59,210
+عشان هيك هنا ضربوا مثال عشان هيك أي أدوية لازم
+
+130
+00:10:59,210 --> 00:11:02,610
+نحكي فيها ونحكي إنه إحنا بناخد هذا الدواء. جاب الـ
+
+131
+00:11:02,610 --> 00:11:07,160
+manager. الفحص الـ test must be performed at daytime.
+
+132
+00:11:07,160 --> 00:11:14,540
+يعني ممكن بأي وقت في اليوم تعمل الفحص يفضل يفضل at
+
+133
+00:11:14,540 --> 00:11:18,760
+the morning. في الصباح الباكر تقريباً معك من الساعة
+
+134
+00:11:18,760 --> 00:11:23,400
+السابعة صباحاً للتاسعة صباحاً في هذا الوقت أفضل وقت من
+
+135
+00:11:23,400 --> 00:11:25,880
+أجل إجراء فحص الـ OGTT.
+
+136
+00:11:28,620 --> 00:11:32,800
+هل جَاءَ. بحكي ليه؟ test usually takes. الفحص بياخد
+
+137
+00:11:32,800 --> 00:11:37,840
+ثلاثة ساعات، ثلاثة hours but can last as long as
+
+138
+00:11:37,840 --> 00:11:42,840
+six hours. كان ياخد ست ساعات معهم، تمام؟ Drink water
+
+139
+00:11:42,840 --> 00:11:47,020
+frequently during the test. عادي، ممكن أثناء وإنت
+
+140
+00:11:47,020 --> 00:11:50,660
+بتعمل الفحص خلال الثلاث ساعات  للفحص ممكن تشرب
+
+141
+00:11:50,660 --> 00:11:55,950
+ماء فقط. الماء اللي مسموح لك تشربه.  الصحابة الأولى
+
+142
+00:11:55,950 --> 00:12:01,050
+والصحابة الأولى الصحابة الهوائية تتجمد بين الساعة
+
+143
+00:12:01,050 --> 00:12:08,230
+السابعة والتاسعة بعد أنك صمت 12 ساعة. هل جَاءَ الكلام
+
+144
+00:12:08,230 --> 00:12:13,490
+اللي موجود بالـ slide. نشوف تحت. Operator gives a
+
+145
+00:12:13,490 --> 00:12:18,070
+test load of glucose usually من 75 إلى 100 جرام من
+
+146
+00:12:18,070 --> 00:12:22,610
+الـ dextrose اللي هو الجلوكوز مدوب بـ 300 مل
+
+147
+00:12:22,610 --> 00:12:28,870
+ماء أو مدوب بالليمون. Drink the entire solution
+
+148
+00:12:28,870 --> 00:12:34,340
+in 5 minutes. هل جَاءَ إحنا كلام السلايدات يعني إحنا
+
+149
+00:12:34,340 --> 00:12:37,140
+بنشوف إيش بيصير عندنا في غزة في الواقع يعني كيف
+
+150
+00:12:37,140 --> 00:12:41,500
+بنعمل الفحص. الفحص عندنا للأمانة بيستغرق two hours
+
+151
+00:12:41,500 --> 00:12:46,380
+فقط ساعتين مش ثلاثة ولا ستة. تمام؟ بيستغرق ساعتين
+
+152
+00:12:46,380 --> 00:12:51,640
+عشان هيك بيسموه الـ two hour الـ two hour oral
+
+153
+00:12:51,640 --> 00:12:56,900
+glucose tolerance test. two hour OGTT. هيك اسم الفحص
+
+154
+00:12:56,900 --> 00:13:02,070
+لأنه بيستغرق ساعتين. تمام؟ إيش بنحكي للست الحامل؟
+
+155
+00:13:02,070 --> 00:13:07,590
+المهم تيجي صايمة من 10 إلى 12 ساعة. أن التحضيرات
+
+156
+00:13:07,590 --> 00:13:12,570
+الأخرى تاكل carbohydrate وما تعملش exercise، هذه
+
+157
+00:13:12,570 --> 00:13:16,110
+كلها شغلات.. هذه الـ standard، شغلات مثالية، بس
+
+158
+00:13:16,110 --> 00:13:19,580
+للأمانة ما بتتطبقش عندنا، يعني هذا اللي بيصير عندنا
+
+159
+00:13:19,580 --> 00:13:24,540
+ست حامل، بقول لها المرة الجاية بدنا نعمل لك OGTT، هذا
+
+160
+00:13:24,540 --> 00:13:28,260
+الفحص، تيجي لي أهم شيء صايمة من عشر إلى اثنتي عشرة
+
+161
+00:13:28,260 --> 00:13:31,480
+ساعة، تيجي صايمة من عشر إلى اثنتي عشرة ساعة، تيجي
+
+162
+00:13:31,480 --> 00:13:37,360
+للمختبر، تمام؟ تجي. أول ما تيجي يفترض أحكي لها معك
+
+163
+00:13:37,360 --> 00:13:41,380
+من الساعة السابعة للساعة التاسعة في هذا الوقت في الصباح
+
+164
+00:13:41,380 --> 00:13:45,780
+الباكر أفضل وقت لصحب العينة تجيني وهي صايمة
+
+165
+00:13:45,780 --> 00:13:51,600
+بسحب لها عينة الدم وهذه العينة بشتغل لها fasting
+
+166
+00:13:51,600 --> 00:13:57,260
+blood sugar بشتغل لها فحص السكر fasting وهي صايمة
+
+167
+00:13:57,260 --> 00:14:01,840
+لأن هي أصلاً صايمة. إذن أول ما تيجي الست الحامل على
+
+168
+00:14:01,840 --> 00:14:05,360
+المختبر وهي صايمة عشر ساعات أو ثمانية أو اثنتي عشرة
+
+169
+00:14:05,360 --> 00:14:12,020
+بسحب منها عينة وهذه العينة بشتغل لها فحص السكر وهذا
+
+170
+00:14:12,020 --> 00:14:17,320
+الفحص بنسميه fasting blood sugar وبسجل النتيجة
+
+171
+00:14:17,320 --> 00:14:22,460
+بنفس الوقت بقول لها تروح تجيب لي عينة بول عشان
+
+172
+00:14:22,460 --> 00:14:27,140
+بالـ strip أشوف في البول فيه سكر ولا لأ. تمام،
+
+1
+
+223
+00:18:43,880 --> 00:18:48,160
+كان يستغرق 6 ساعات، و3 ساعات كل نصف ساعة بيسحب
+
+224
+00:18:48,160 --> 00:18:51,480
+عينة من الست كل نصف ساعة بيسحب عينة من الست، وهذا
+
+225
+00:18:51,480 --> 00:18:55,840
+كثير مجهد، و..و.. وبتعب نفسية المريض، تمام؟
+
+226
+00:18:57,830 --> 00:19:01,810
+هلجيت، بس بدي أحكي عن الـNormal Range اللي خاص
+
+227
+00:19:01,810 --> 00:19:05,130
+بالـTwo Hour Oral Glucose Tolerance Test عندنا
+
+228
+00:19:05,130 --> 00:19:09,630
+بقول، لو بعد ساعتين، يعني بعد ما أعطيتك جرعة السكر
+
+229
+00:19:09,630 --> 00:19:14,170
+تمام، بعد ساعتين لما أجي أعملك فحص السكر، إذا طلع
+
+230
+00:19:14,170 --> 00:19:18,730
+سكرك 110 milligram per deciliter أو أقل، هذا إنسان
+
+231
+00:19:18,730 --> 00:19:24,040
+Normal، بين 140 لـ 200 ملي جرام per deciliter، هذا
+
+232
+00:19:24,040 --> 00:19:28,000
+إنسان pre-diabetic، يعني عنده risk factor للمستقبل
+
+233
+00:19:28,000 --> 00:19:33,940
+أنه يصاب بمرض السكري، لو طلع سكره 200 ملي جرام per
+
+234
+00:19:33,940 --> 00:19:38,260
+deciliter أو أعلى من 200، هذا بيكون مؤكد diabetic
+
+235
+00:19:38,260 --> 00:19:43,170
+إنسان مريض سكري، اللي أمامنا جدول، أكيد مش حفظ، بس
+
+236
+00:19:43,170 --> 00:19:48,450
+بدنا نفهم، ونفهم الـCalculation، بظهر لك كل عالم كيف
+
+237
+00:19:48,450 --> 00:19:53,410
+كان بيشتغل فحص الـOGTT، لأنه كل عالم استخدم طريقة
+
+238
+00:19:53,410 --> 00:19:59,190
+مختلفة لشغل الـOGTT، وبرضه تحليل نتيجة الـOGTT
+
+239
+00:19:59,190 --> 00:20:05,150
+برضه مختلفة من عالم لعالم، تمام؟ هلجيت عندنا، والـ
+
+240
+00:20:05,150 --> 00:20:08,690
+Carson criteria العالم، والـCarson كيف اشتغل الـ
+
+241
+00:20:08,690 --> 00:20:13,210
+OGTT، وكيف حلل النتيجة، بتيجي السيدة صايمة
+
+242
+00:20:13,210 --> 00:20:17,170
+fasting، تمام، وبيسحب منها عينة، وبيشتغل لها فحص
+
+243
+00:20:17,170 --> 00:20:23,030
+السكر fasting blood sugar، لو طلع سكرها 130 أو أعلى
+
+244
+00:20:23,030 --> 00:20:28,130
+من 130، بأعطيها 1 point، بأعطيها درجة، طيب لو سكرها
+
+245
+00:20:28,130 --> 00:20:32,850
+كان أقل من 130، بيعطيها صفر، يعني ما فيش لها ولا
+
+246
+00:20:32,850 --> 00:20:37,690
+درجة، بعدين بيعطيها المحلول السكري، بعد نصف ساعة ما
+
+247
+00:20:37,690 --> 00:20:41,630
+بيسحب لها دم، هي حاطة شُحطة، يعني ما بيسحب لها دم بعد
+
+248
+00:20:41,630 --> 00:20:46,690
+ساعة من إعطاءها محلول السكر، بيسحب لها دم، لو طلع
+
+249
+00:20:46,690 --> 00:20:52,440
+أعلى من 190، إذا بأعطيها نصف درجة، أقل من 190
+
+250
+00:20:52,440 --> 00:20:56,280
+milligram per deciliter، صفر، بأعطيها شوية درجة، ع
+
+251
+00:20:56,280 --> 00:21:00,500
+الساعة ونصف، يعني عـ90 minutes، ما بيسحب لها، عـ
+
+252
+00:21:00,500 --> 00:21:05,930
+الساعتين، يعني عـ120 minutes، بيسحب، وبيفحصها، لو
+
+253
+00:21:05,930 --> 00:21:10,810
+طلع دمها أكثر من، سكر الدم أكثر من 140 milligram
+
+254
+00:21:10,810 --> 00:21:14,970
+per deciliter، بعطيها نصف point، نصف درجة، أقل من 140
+
+255
+00:21:14,970 --> 00:21:18,930
+ما بيعطيها ولا درجة، صفر، عـالساعتين ونصف برضه
+
+256
+00:21:18,930 --> 00:21:23,130
+بيسحب لها عينة دم أخرى، طلع أكثر من 130 milligram
+
+257
+00:21:23,130 --> 00:21:27,450
+per deciliter، بعطيها point، أقل من 130 ما بيعطيها
+
+258
+00:21:27,450 --> 00:21:31,390
+ولا point، صفر، الـResult في الآخر بيقول لك بيجمع الـ
+
+259
+00:21:31,390 --> 00:21:35,010
+points، بيجمع النقاط، لو طلعت من اتنين لتلاتة point
+
+260
+00:21:35,010 --> 00:21:39,350
+بتكون هذه السيدة diabetic، لو طلع مجموع نقاطها من نصف
+
+261
+00:21:39,350 --> 00:21:42,770
+لواحد ونصف point، بتكون Suspected، يعني pre-diabetic
+
+262
+00:21:42,770 --> 00:21:48,050
+لو طلع مجموع النقاط صفر، معناها Non-diabetic، هنا
+
+263
+00:21:48,050 --> 00:21:53,370
+لو جمعناها نقطة، نقطتين ونصف،  نصف، نقطة، يعني هاي
+
+264
+00:21:53,370 --> 00:21:57,850
+تلاتة point، تلاتة point، صنفها Diabetic، أما إيجي عالم
+
+265
+00:21:57,850 --> 00:22:02,710
+آخر، Vajankund criteria، الست بتكون okay، صايمة، لكن
+
+266
+00:22:02,710 --> 00:22:06,830
+ما بيسحب لها عينة وهي صايمة، وبيعطيها جرعة السكر، ما
+
+267
+00:22:06,830 --> 00:22:10,010
+بيسحب لها عينة على الثلاثين minute، بيسحب لها عينة
+
+268
+00:22:10,010 --> 00:22:13,600
+على الساعة، عـالـ60 minutes، يعني بعد ما يعطيها جرعة
+
+269
+00:22:13,600 --> 00:22:18,780
+السكر بساعة، لو طلعت أعلى من 190، بعطيها plus 1، أقل
+
+270
+00:22:18,780 --> 00:22:23,160
+من 190، بعطيها صفر، وعالساعة ونصف، يعني عـالـ90
+
+271
+00:22:23,160 --> 00:22:28,320
+minutes، برضه بيحسب لها، وبيسحب لها عينة، وبيحسب نسبة
+
+272
+00:22:28,320 --> 00:22:33,740
+السكر فيها، أعلى من 165، بعطيها plus 1، أقل من 165
+
+273
+00:22:33,740 --> 00:22:39,140
+بعطيها صفر، عـالساعتين، يعني عـالـ120 minutes، برضه
+
+274
+00:22:39,140 --> 00:22:44,360
+بيسحب لها كمان عينة، طلع السكر أعلى من 140، بيعطيها
+
+275
+00:22:44,360 --> 00:22:49,460
+plus 1، أقل من 140، بيعطيها صفر point، في الآخر بيجمع
+
+276
+00:22:49,460 --> 00:22:54,920
+النقاط، لو طلعت تلاتة مجموعهم، إذا هي Diabetic، من 1 لـ 2
+
+277
+00:22:54,920 --> 00:22:59,980
+suspect، إذا ما فيش كل صفر، إذا ما هي Diabetic، هنا تلاتة
+
+278
+00:22:59,980 --> 00:23:04,620
+مجموعهم plus 1، plus 1، plus 1، إذا هي Diabetic، آخر عالم
+
+279
+00:23:04,620 --> 00:23:09,720
+revised some nation، هذا العالم إيش قال؟ بيجستت
+
+280
+00:23:09,720 --> 00:23:13,240
+بيعمل لها الفحص وهي صايمة، F معناها fasting blood
+
+281
+00:23:13,240 --> 00:23:17,280
+sugar، تمام، وهي صايمة بيعمل لها الفحص، وبيسجل الـ
+
+282
+00:23:17,280 --> 00:23:22,880
+result تبعت السكر، بروح عـالساعة، بعدين بيعطيها جرعة
+
+283
+00:23:22,880 --> 00:23:26,600
+السكر، بعد ساعة من إعطاءها محلول السكري، يعني عـ
+
+284
+00:23:26,600 --> 00:23:31,560
+الـ60 دقيقة، بيسحب لها عينة، وبعد ساعة ونصف، يعني عـ
+
+285
+00:23:31,560 --> 00:23:36,180
+الـ90 دقيقة، برضه بيسحب لها عينة، وعـالـ120 دقيقة
+
+286
+00:23:36,180 --> 00:23:40,840
+يعني بعد ساعتين، برضه بيسحب لها عينة، وفي كل مرة
+
+287
+00:23:40,840 --> 00:23:45,080
+بيفحص لها مستوى السكر، نسبة السكر في الدم، هلجيت الـ
+
+288
+00:23:45,080 --> 00:23:50,560
+results، النتيجة، يعني وهي صايمة، وعـالساعة، وعـالساعة
+
+289
+00:23:50,560 --> 00:23:55,400
+ونصف، وعـالساعتين، الـresults تبعت السكر، نسب السكر
+
+290
+00:23:55,400 --> 00:23:59,940
+بيروحوا هو بيجمعهم، عامل لهم summation، مثلاً طلع السكر
+
+291
+00:23:59,940 --> 00:24:05,520
+عندي 120، المرة الثانية 105، 200، 300، بجمع هذه
+
+292
+00:24:05,520 --> 00:24:12,850
+الأرقام، تمام؟ ولو طلع مجموع السكر فيها، هاي في الـ
+
+293
+00:24:12,850 --> 00:24:15,850
+Fasting، والـ60 Minutes، والـ90 Minutes، والـ
+
+294
+00:24:15,850 --> 00:24:19,450
+120 Minutes، لو طلع مجموع السكر أعلى من 600
+
+295
+00:24:19,450 --> 00:24:22,770
+milligrams per deciliter، إذا الست بتكون Diabetic
+
+296
+00:24:22,770 --> 00:24:27,110
+لو الـSummation لنسب السكر كانت أقل من 600
+
+297
+00:24:27,110 --> 00:24:30,290
+milligrams per deciliter، إذا هي Non-Diabetic
+
+298
+00:24:30,290 --> 00:24:35,150
+نستنتج من هنا، طبعاً لا بدنا نحفظ، ولا بدنا نعرف شيء
+
+299
+00:24:35,150 --> 00:24:39,890
+بس أهم شيء نفهم إن كل عالم كانت طريقة شغله للفحص
+
+300
+00:24:39,890 --> 00:24:44,170
+مختلفة، والـInterpretation برضه للنتائج، وتحليله
+
+301
+00:24:44,170 --> 00:24:51,150
+للنتائج برضه كانت مختلفة، واتحطّ "Insulin levels explain the glucose tolerance curve"، هذا الـcurve
+
+302
+00:24:51,150 --> 00:24:54,230
+already، احنا يا جماعة حكيناه قبل، هذا الـcurve
+
+303
+00:24:54,230 --> 00:24:57,890
+اسمه tolerance curve، لإنسان سليم اللي جسمه بيقدر
+
+304
+00:24:57,890 --> 00:25:02,230
+يتعامل مع جرعة السكر اللي بياخدها، اللون البنفسجي،
+
+305
+00:25:06,470 --> 00:25:10,530
+الـMove هو خط الإنسولين، واللون الأخضر هو خط
+
+306
+00:25:10,530 --> 00:25:16,050
+الجلوكوز، هلجيت لو جينا عـالـY-axis، عند 90 ملي
+
+307
+00:25:16,050 --> 00:25:19,850
+جرام per deciliter، هذه نسبة السكر عند الإنسان
+
+308
+00:25:19,850 --> 00:25:23,530
+الطبيعي، احنا حكينا من 70 لـ110، هو طالع عنده 90
+
+309
+00:25:23,530 --> 00:25:28,310
+هلجيت لو رحت أنا أعطيته جرعة سكر، إيش بتتخيلوا
+
+310
+00:25:28,310 --> 00:25:33,190
+المنحنى الأخضر راح يصير، راح يرتفع؟ يعني سكره راح يزيد في
+
+311
+00:25:33,190 --> 00:25:38,170
+الدم، تمام، راح يزيد، في المقابل، لما السكر يزيد في
+
+312
+00:25:38,170 --> 00:25:42,650
+الدم، كمان الإنسولين بده يزيد، هاي الخط البنفسجي
+
+313
+00:25:42,650 --> 00:25:46,310
+زاد، هاي الاثنين زادوا مع بعض، ليش الإنسولين زاد؟
+
+314
+00:25:46,310 --> 00:25:51,030
+عشان بده يبدأ يخفض من مستوى السكر، عند حد معين،
+
+315
+00:25:51,030 --> 00:25:55,030
+شوفوا الـcurve الأخضر، إيش صار فيه؟ الخط الأخضر
+
+316
+00:25:55,030 --> 00:26:00,210
+نزل، معناه السكر بدأ ينزل، ليش؟ لأن الإنسولين خفضه
+
+317
+00:26:00,700 --> 00:26:05,500
+لما السكر بدأ ينزل، تمام، برضه الإنسولين بده يبدأ
+
+318
+00:26:05,500 --> 00:26:10,980
+ينزل، عشان ما فيش شيء  داله مرتفع، إذا الإنسولين خفض
+
+319
+00:26:10,980 --> 00:26:15,560
+السكر، هي الـcurve الأخضر بدأ ينزل، ولما نزل السكر
+
+320
+00:26:15,560 --> 00:26:21,280
+برضه بدأ الإنسولين، خلاص بدأ الإنسولين ينخفض، وبطل
+
+321
+00:26:21,280 --> 00:26:27,280
+ينفرز، لأن السكر انخفض، تمام؟ هذا اللي بدنا نفهمه من
+
+322
+00:26:27,280 --> 00:26:32,520
+الرسمة، لو قرأنا المربعات اللي لونهم Orange، Rising
+
+323
+00:26:32,520 --> 00:26:36,260
+blood glucose stimulate insulin production، ارتفاع
+
+324
+00:26:36,260 --> 00:26:40,920
+مستوى السكر أدى إلى زيادة مستوى الإنسولين في الدم
+
+325
+00:26:40,920 --> 00:26:46,500
+High level من الإنسولين، لما زاد الإنسولين سبب drop in
+
+326
+00:26:46,500 --> 00:26:51,320
+blood glucose، سبب انخفاض في مستوى السكر، as a
+
+327
+00:26:51,320 --> 00:26:57,300
+glucose level، لما مستوى السكر انخفض، there is less
+
+328
+00:26:57,300 --> 00:27:01,360
+stimulation for insulin production، بطل في عندنا محفز
+
+329
+00:27:01,360 --> 00:27:06,060
+للانسولين يظل عالي وموجود في الدم، and insulin drop
+
+330
+00:27:06,060 --> 00:27:10,860
+برضه الإنسولين انخفض، والـInsulin level returned to
+
+331
+00:27:10,860 --> 00:27:15,100
+normal، بعد هيك خلاص رجع الإنسولين لتركيزه الطبيعي
+
+332
+00:27:15,100 --> 00:27:21,120
+الجلوكوز بدأ يرتفع بشكل تدريجي، لحد ما يصل لوضعه
+
+333
+00:27:21,120 --> 00:27:25,040
+الطبيعي، اللي بدنا نفهمه أن الاثنين بيرتفعوا مع بعض
+
+334
+00:27:25,040 --> 00:27:30,480
+والاثنين بنخفضوا مع بعض، تمام؟ لأنه لو ارتفع السكر،
+
+335
+00:27:30,480 --> 00:27:34,960
+راح يزيد الإنسولين عشان يخفض السكر، ولو نزل السكر
+
+336
+00:27:34,960 --> 00:27:39,580
+وانخفض، خلاص الإنسولين خلص دوره، برضه راح ينخفض، ويرجع
+
+337
+00:27:39,580 --> 00:27:45,250
+لوضعه الطبيعي، هلجيت يا جماعة؟ بدنا نحكي لكم عن الـ
+
+338
+00:27:45,250 --> 00:27:49,350
+Normal Range، نحكي، وبعدين نشوف الـSlides بما يخص
+
+339
+00:27:49,350 --> 00:27:53,670
+فحص الـTwo Hour Oral Glucose Tolerance Test
+
+340
+00:27:53,670 --> 00:27:59,270
+الوضع الطبيعي، لو طلع الشخص سكره 110 milligram per
+
+341
+00:27:59,270 --> 00:28:04,870
+deciliter أو أقل، إذا هذا إنسان Normal، وسليم، طيب لو
+
+342
+00:28:04,870 --> 00:28:10,690
+طلع السكر عنده من 140 لـ200، في هذا الـrange، من
+
+343
+00:28:10,690 --> 00:28:15,690
+140 لـ200 milligram per deciliter، هذا pre-diabetic
+
+344
+00:28:15,690 --> 00:28:19,190
+الـpre-diabetic، يعني عنده risk factor في المستقبل
+
+345
+00:28:19,190 --> 00:28:25,720
+لإصابة بالسكري، لو طلع سكره 200 أو أعلى من 200، فهذا
+
+346
+00:28:25,720 --> 00:28:31,380
+أكيد Diabetic، هذه الـNormal Range الصحيحة، والخاصة
+
+347
+00:28:31,380 --> 00:28:37,250
+بفحص الـOral Glucose Tolerance Test، تمام؟ أما
+
+348
+00:28:37,250 --> 00:28:42,570
+بالنسبة للـNormal Range الخاصة بأول فحص أخذناه
+
+349
+00:28:42,570 --> 00:28:46,770
+الـFasting Blood Sugar، تمام؟ هذا الفحص اللي احنا
+
+350
+00:28:46,770 --> 00:28:53,030
+كلنا بنعمله، الوضع الطبيعي من 70 لـ110 milligram per
+
+351
+00:28:53,030 --> 00:28:59,720
+deciliter، لكن هذا إنسان Normal، لكن لو طلع من 110 لـ
+
+352
+00:28:59,720 --> 00:29:04,500
+126 milligram per deciliter، هذا بيكون pre-diabetic
+
+353
+00:29:04,500 --> 00:29:11,440
+لو طلع السكر 126 أو أعلى، هذا بيكون إنسان أكيد
+
+354
+00:29:11,440 --> 00:29:15,120
+Diabetic، وأكيد مريض سكري، ما بنخربط بين
+
+355
+00:29:15,120 --> 00:29:20,560
+الـNormal Range الخاصة بفحص الـOGTT، والخاصة بفحص
+
+356
+00:29:20,560 --> 00:29:26,690
+الـfasting blood sugar، تمام؟ نشوف أول نقطة باللون
+
+357
+00:29:26,690 --> 00:29:31,170
+الأحمر، Normal Response، هنا جزء الـNormal Range
+
+358
+00:29:31,170 --> 00:29:36,110
+الخاصة بالـOral Glucose Tolerance Test، a person
+
+359
+00:29:36,110 --> 00:29:39,690
+is said to have a normal response when the two
+
+360
+00:29:39,690 --> 00:29:43,650
+-hour glucose level is less than or equal to 110
+
+361
+00:29:43,650 --> 00:29:48,110
+milligram per deciliter، هذا الوضع الطبيعي، للإنسان
+
+362
+00:29:48,110 --> 00:29:52,510
+الطبيعي، لو عملت له فحص الـOGTT، بده يطلع السكر عنده
+
+363
+00:29:52,510 --> 00:29:58,910
+110 أو أقل، عشان أقدر أحكي عنه طبيعي، أما النقطة
+
+364
+00:29:58,910 --> 00:30:03,030
+الثالثة، سيبوني من النقطة الثانية، النقطة الثالثة
+
+365
+00:30:03,030 --> 00:30:07,150
+بتقول لي "Impaired glucose tolerance"، كلمة
+
+366
+00:30:07,150 --> 00:30:12,810
+"Impaired" معناه يعني فيه خلل، فيه مشكلة، ممكن أحكي
+
+367
+00:30:12,810 --> 00:30:16,930
+عنها الـpre-diabetic، تمام؟ "Impaired" معناه خلل
+
+368
+00:30:16,930 --> 00:30:23,080
+أو مشكلة في الـglucose tolerance، "الشخص يعاني من خلل في  تحرير الجلوكوز"، متى بقول عن هذا الشخص عنده خلل
+
+369
+00:30:23,080 --> 00:30:27,540
+عنده مشكلة في الجلوكوز توليرانس، when the two hour
+
+370
+00:30:27,540 --> 00:30:32,080
+glucose results from the oral glucose tolerance
+
+371
+00:30:32,080 --> 00:30:36,340
+test are greater than or equal to مئة وأربعين
+
+374
+00:30:47,580 --> 00:30:52,640
+لو عملت لشخص فحص الـOral Glucose Tolerance
+
+375
+00:30:52,640 --> 00:30:57,900
+Test، تمام؟ وبعد ما أعطيته جرعة السكر بساعتين
+
+376
+00:30:57,900 --> 00:31:05,230
+فحصت له السكر، طلعت النتيجة ما بين الـ140 للـ200، يعني
+
+377
+00:31:05,230 --> 00:31:10,510
+بهذه الحدود، Range، ما بين الـ140 والـ200 milligram
+
+378
+00:31:10,510 --> 00:31:14,770
+per deciliter، بحكي عن هذا الشخص الـpre-diabetic
+
+379
+00:31:14,770 --> 00:31:19,310
+إيش يعني pre-diabetic؟ يعني هو عنده Impaired، عنده
+
+380
+00:31:19,310 --> 00:31:24,460
+خلل، عنده مشكلة، عنده risk factor لإصابة بالسكري
+
+381
+00:31:24,460 --> 00:31:28,600
+في المستقبل، فتعطيه حمية، تقوله العب، exercise، ما
+
+382
+00:31:28,600 --> 00:31:32,760
+تأكلش أكلات، لأنه احتمال في المستقبل يصير عندك سكري
+
+383
+00:31:32,760 --> 00:31:38,300
+أما النقطة اللي في النص، Impaired fasting glucose
+
+384
+00:31:38,300 --> 00:31:43,920
+بيقصد فيها فحص الـfasting blood sugar اللي أخذناه
+
+385
+00:31:43,920 --> 00:31:50,130
+أول مرة، when a person has fasting glucose equal to
+
+386
+00:31:50,130 --> 00:31:56,210
+or greater than 110 and less than 126. This is
+
+387
+00:31:56,210 --> 00:32:00,070
+considered a risk factor for future diabetes. هذا
+
+388
+00:32:00,070 --> 00:32:05,
\ No newline at end of file
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/a3GO5ndJhG8_postprocess.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/a3GO5ndJhG8_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..fc6632bea67d8a12d578ad853fe4356e5afcebff
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/a3GO5ndJhG8_postprocess.srt
@@ -0,0 +1,1678 @@
+1
+00:00:00,000 --> 00:00:05,140
+بدنا هالجهة نبدأ بفحص الـ OGTT اختصار لـ Oral
+
+2
+00:00:05,140 --> 00:00:11,800
+Glucose Tolerance Test فكرة الفحص بكل بساطة فكرة
+
+3
+00:00:11,800 --> 00:00:17,060
+فحص ال OGTT Oral Glucose من اسمه إنه بيجيك شخص بدي
+
+4
+00:00:17,060 --> 00:00:22,590
+يعمل هذا الفحص بدي يعمل فحص ال OGTTبروح بقى أعطيه
+
+5
+00:00:22,590 --> 00:00:29,250
+قطعة سكر أو سكر مدوب بميه هالجيت بنشوف كيف وبيشربه
+
+6
+00:00:29,250 --> 00:00:33,090
+هالجيت لو جسمه طبيعي الوضع الطبيعي انت أكلت شغل
+
+7
+00:00:33,090 --> 00:00:38,120
+فيها سكر معناه السكر في الدم عندك هيزيدنتيجة زيادة
+
+8
+00:00:38,120 --> 00:00:42,460
+السكر في الدم الإنسولين بتحسس لهذا السكر بيبقى
+
+9
+00:00:42,460 --> 00:00:47,460
+يطلع الإنسولين على الدم وبيبدأ الإنسولين ياخد هذا
+
+10
+00:00:47,460 --> 00:00:52,700
+السكر الموجود في الدم ويبدأش يساوي فيه، يدخله جواه
+
+11
+00:00:52,700 --> 00:00:57,660
+الخلايا عشان دور الإنسولين بديخفض مستوى السكر
+
+12
+00:00:57,660 --> 00:01:03,510
+الموجود في الدمهذا بكل بساطة اللي بيصير هذا أنت
+
+13
+00:01:03,510 --> 00:01:09,710
+إنسان طبيعي استطاع جسمك يتعامل كلمة يتعامل هنا
+
+14
+00:01:09,710 --> 00:01:14,510
+معناها tolerance يتحمل يتعامل لأن جسمك طبيعي
+
+15
+00:01:14,510 --> 00:01:20,650
+استطاع جسمك يتعامل مع جرعة السكر اللي أنا أعطيتك
+
+16
+00:01:20,650 --> 00:01:25,980
+إياهاتمام؟ على سبيل النقط، لو جينا لإنسان عنده
+
+17
+00:01:25,980 --> 00:01:30,500
+مشاكل بالإنسولين وعنده مشاكل بهرمون الإنسولين،
+
+18
+00:01:30,500 --> 00:01:35,320
+أعطيته جرعة سكر، شربها، أكلها، أيا كان، قطعة سكر،
+
+19
+00:01:35,320 --> 00:01:39,810
+سكر في الدم هيزيدعنده مشكلة بالإنسولين هرمون
+
+20
+00:01:39,810 --> 00:01:44,050
+الإنسولين لم يتم إفرازه وبالتالي إيش هيصير في
+
+21
+00:01:44,050 --> 00:01:50,270
+السكر؟ هيظل عالي معناه بنستنتج إن جثم هذا الشخص
+
+22
+00:01:50,270 --> 00:01:54,630
+انتولرانس كلمة intolerance عكس tolerance
+
+23
+00:01:54,630 --> 00:02:00,110
+intolerance معناه لم يتعامل مع جرعة السكر اللي أنا
+
+24
+00:02:00,110 --> 00:02:07,180
+أعطيته إياهإذن بشكل مبسط الإنسان الطبيعي بقدر
+
+25
+00:02:07,180 --> 00:02:11,340
+يتعامل مع جرعة السكر اللي أنا بعطيله إياها
+
+26
+00:02:11,340 --> 00:02:15,900
+Tolerance، يتحمل لإنه عنده إنسلين والإنسلين هيخفض
+
+27
+00:02:15,900 --> 00:02:19,900
+السكر عنده في الدم لكن الإنسان تاني عنده problem،
+
+28
+00:02:19,900 --> 00:02:25,320
+عنده مشاكل في الإنسلين لو أنا أعطيته جرعة سكر جسمه
+
+29
+00:02:25,320 --> 00:02:30,550
+IntoleranceIntolerance معناه لا يستطيع أن يتعامل
+
+30
+00:02:30,550 --> 00:02:34,590
+مع جرعة السكر اللي أنا أعطيته إياه لإنه بكل بساطة
+
+31
+00:02:34,590 --> 00:02:40,390
+الإنسولين فيه مشاكل، تمام؟ هذه فكرة الفحص On a
+
+32
+00:02:40,390 --> 00:02:45,270
+standard oral glucose dose لما أنا أعطيك جرعة من
+
+33
+00:02:45,270 --> 00:02:50,650
+الجلوكوس، طبعا الجلوكوس مش محلول، بتم تناوله عن
+
+34
+00:02:50,650 --> 00:02:55,750
+طريق الفم، تمام؟ بنشرب شرب أو بتاكل جرعة من السكر
+
+35
+00:02:56,390 --> 00:03:01,450
+التجارب عن تجارب الجلوكوز والمتابوليزم لتجارب
+
+36
+00:03:01,450 --> 00:03:06,270
+الجلوكوز يجب أن تكون تولرانة في ملاحظة الانتصاف
+
+37
+00:03:06,270 --> 00:03:11,770
+الطبيعي والعودة هنا حيصير في استجابة لجسمك جسمك
+
+38
+00:03:11,770 --> 00:03:17,230
+هينتص و هيعمل عمليات لهذا الجلوكوز هيطلع الإنسولين
+
+39
+00:03:17,960 --> 00:03:23,640
+هذا الإنسلين بالأول السكر ارتفع الإنسلين هييجي
+
+40
+00:03:23,640 --> 00:03:28,600
+يدخل السكر على الخلايا وبالتالي يـreturn برجع
+
+41
+00:03:28,600 --> 00:03:34,020
+السكر لوضعه الطبيعي تمام؟ إذا جسمك tolerant، اتحمل
+
+42
+00:03:34,020 --> 00:03:39,440
+whereas على سبيل العكس والنقد abnormal and
+
+43
+00:03:39,440 --> 00:03:43,700
+improper glucose metabolism is termed glucose
+
+44
+00:03:43,700 --> 00:03:49,100
+intoleranceالثاني عنده مشكلة في العمليات الخاصة
+
+45
+00:03:49,100 --> 00:03:54,160
+بالجلوكوز مشكلة أنه فيش إنسولين مثلا يخفض مستوى
+
+46
+00:03:54,160 --> 00:03:59,000
+السكر عنده وبالتالي جسمه intolerance مش قادر
+
+47
+00:03:59,000 --> 00:04:03,740
+يتعامل مع جرعة السكر اللي أنا أعطيته إياهاهذه فكرة
+
+48
+00:04:03,740 --> 00:04:08,460
+فحص الـ Oral Glucose Tolerance Test هل جسمك بقدر
+
+49
+00:04:08,460 --> 00:04:13,920
+يتعامل أو لا يستطيع أن يتعامل مع جرعة السكر اللي
+
+50
+00:04:13,920 --> 00:04:18,890
+تم إعطائك إياها، تمام؟this used to diagnose
+
+51
+00:04:18,890 --> 00:04:24,010
+diseases where the glucose metabolism is impaired
+
+52
+00:04:24,010 --> 00:04:29,410
+as in diabetes mellitus فحص ال OGTT مثل فحص ال
+
+53
+00:04:29,410 --> 00:04:34,690
+fasting blood sugar يستخدم بغرض ال diagnosis بغرض
+
+54
+00:04:34,690 --> 00:04:41,660
+التشخيص أقول هل عندكمرض سكري أم سليم، إذا الهدف
+
+55
+00:04:41,660 --> 00:04:45,820
+منه يعني أنا بقدر أعمل فحص الـ OGTT، أي شخص بقدر
+
+56
+00:04:45,820 --> 00:04:49,480
+يعمل فحص الـ OGTT عشان يعرف عنده سكري ولا لا،
+
+57
+00:04:49,480 --> 00:04:54,480
+تمام؟تمام الـ Orange glucose tolerance test هذا
+
+58
+00:04:54,480 --> 00:05:00,340
+الفحص has been widely used as the golden standard
+
+59
+00:05:00,340 --> 00:05:05,160
+for diagnoses of diabetes mellitus in clinically
+
+60
+00:05:05,160 --> 00:05:11,300
+doubtful cases هذا الفحص بشكل منتشر وواسع هو الـ
+
+61
+00:05:11,300 --> 00:05:16,120
+golden standard هو الفحص المثالي الذهبي من أجل
+
+62
+00:05:16,120 --> 00:05:21,460
+التشخيصمن أجل إني أحكي عنك شخص سليم و لا عندك مرض
+
+63
+00:05:21,460 --> 00:05:27,320
+سكري خاصة في الحالات الـDoubtful cases الحالات
+
+64
+00:05:27,320 --> 00:05:31,680
+المشكوك في أمرها اللي لو أنا عملتلها fasting blood
+
+65
+00:05:31,680 --> 00:05:37,120
+sugar بتكونش واضحة كتير عنده سكري و لا لأ فبنطلبله
+
+66
+00:05:37,120 --> 00:05:41,240
+الـ OGTT تمام؟ في الحالات المشكوك في أمرها
+
+67
+00:05:41,240 --> 00:05:44,620
+والحالات العادية اللي بدي أعرف عنده سكر و لا لأ
+
+68
+00:05:44,620 --> 00:05:51,500
+إذا انفحص، لا تتشخيصLately throughout the use of
+
+69
+00:05:51,500 --> 00:05:57,860
+OGTT in primary care has been questioned for
+
+70
+00:05:57,860 --> 00:06:03,140
+several reasons طبعا فحص الـ OGTT فحص بيعمله في
+
+71
+00:06:03,140 --> 00:06:07,720
+الرعاية الأولية وفي المستشفيات لعدة أسباب، بينطلب
+
+72
+00:06:07,720 --> 00:06:13,590
+لعدة أسبابIt has law reproducibility and is very
+
+73
+00:06:13,590 --> 00:06:17,910
+expensive للأسف هذا الفحص مع إنه الفحص الدهبي من
+
+74
+00:06:17,910 --> 00:06:22,390
+أجل التشخيص هل عندك سكري ولا لأ إلا إنه فيه عيوب
+
+75
+00:06:22,390 --> 00:06:27,110
+إنه كتير غالي مش يعني مش كتير كتير غالي إنه لو
+
+76
+00:06:27,110 --> 00:06:31,370
+بدنا نيجي نحكي فحص السكر فحص السكر هذا فحص روتيني
+
+77
+00:06:31,630 --> 00:06:36,110
+يعني يفترض يكون سعره ما يزيدش عن 10 شكل لكن لم
+
+78
+00:06:36,110 --> 00:06:40,450
+أبدأ أحكي لك أعمل فحص السكر بـ20 أو بـ30 زي فحص
+
+79
+00:06:40,450 --> 00:06:44,110
+الـ OGTT، هذه مشكلة إذن المشكلة الأساسية بهذا
+
+80
+00:06:44,110 --> 00:06:49,370
+الفحص إنه كثير غالي ومش دايما بنطلب however for
+
+81
+00:06:49,370 --> 00:06:53,330
+the detection of diabetes in a pregnant woman is
+
+82
+00:06:53,330 --> 00:06:59,390
+still recommended ما زال هذا الفحصاللي بيوصف فيه
+
+83
+00:06:59,390 --> 00:07:04,870
+إنه ينعمل للستات الحوامل اللي بيشكوا إنه عندهم سكر
+
+84
+00:07:04,870 --> 00:07:10,010
+حمل وبيني وبينكم في المستشفيات هذا الفحص بينعملش
+
+85
+00:07:10,010 --> 00:07:14,530
+يعني أنا لو شك عندي سكر ولا لأ بروح المستشفى بعمل
+
+86
+00:07:14,530 --> 00:07:18,990
+فحص ال fasting blood sugar العادي تمام؟ بصوم تمام
+
+87
+00:07:18,990 --> 00:07:24,050
+ساعات و بروح أعملهبس فحص الـ OGTT هنا بينعمل فقط
+
+88
+00:07:24,050 --> 00:07:29,490
+بعيادات الوكالة للستات الحوامل اللي شاكين في عندها
+
+89
+00:07:29,490 --> 00:07:35,380
+سكر حمنهل جيت الشخص اللي بدي يعمل هذا الفحص سواء
+
+90
+00:07:35,380 --> 00:07:39,880
+ست حامل وشاكين عندها سكري أو الشخص العادي بدي يشوف
+
+91
+00:07:39,880 --> 00:07:44,100
+عنده سكر ولا لأ أو طفل انولد شاكين في عنده سكر ولا
+
+92
+00:07:44,100 --> 00:07:48,320
+لأ لازم يكون فيه preparation فيه تحضير للمريض أول
+
+93
+00:07:48,320 --> 00:07:53,380
+إشي ممنوع تعمل أي activity أي نشاط أو جهد don't
+
+94
+00:07:53,380 --> 00:07:58,860
+smoke ممنوع التدخين أو أي exercise يكون نشاطات
+
+95
+00:07:59,450 --> 00:08:05,610
+تعتمد مجهود وصعبة، ممنوع تعملها لمدة 8 ساعات قبل
+
+96
+00:08:05,610 --> 00:08:10,110
+إجراء الفحص أو خلال وانت بتعمل الفحص إذا ممنوع
+
+97
+00:08:10,110 --> 00:08:14,810
+التدخين، ممنوع الـActivity، ممنوع الـExercise لمدة
+
+98
+00:08:14,810 --> 00:08:18,990
+8 ساعات قبل إجراء الفحص يعني قبل 8 ساعات من إجراءك
+
+99
+00:08:18,990 --> 00:08:24,950
+للفحص، بدك تمتنع عن هذه الشغلاتتمام؟ برضه هذا
+
+100
+00:08:24,950 --> 00:08:29,010
+الفحص يعني أنا عارفة إن الأسبوع اللي جاي بيدروح
+
+101
+00:08:29,010 --> 00:08:35,010
+أعمل فحص الـ OGTT لازم أحضر نفسي جابل تلت أيام من
+
+102
+00:08:35,010 --> 00:08:40,050
+عمل الفحص لازم هذه التلت أيام أكل فيها
+
+103
+00:08:40,050 --> 00:08:46,010
+carbohydrate كتير أغذي حالي شوية، تمام؟ Diet، eat
+
+104
+00:08:46,010 --> 00:08:51,850
+a high carbohydrate diet بدك تاكل أكلات مليئة بالـ
+
+105
+00:08:51,850 --> 00:08:58,380
+carbohydrateبداك تاكل تقريبا الوشبه يكون فيها 150
+
+106
+00:08:58,380 --> 00:09:03,580
+جرام يوميا بدي يكون الأكل تبعك فيه Carbohydrate
+
+107
+00:09:03,580 --> 00:09:09,400
+أكتر من 150 جرام يوميا لمدة تلت أيام، إذا قبل ما
+
+108
+00:09:09,400 --> 00:09:14,020
+تعمل الفحص بتلت أيام، بداك تغذي حالك، تاكل وشبهات
+
+109
+00:09:14,020 --> 00:09:19,560
+مليئة بالـ Carbohydratethen وبعد هيك بعد التلت
+
+110
+00:09:19,560 --> 00:09:23,600
+أيام اليوم الرابع بدك تعمل فحص بعد هيك بدك تبدأ
+
+111
+00:09:23,600 --> 00:09:29,740
+تصوم then fast لازم قبل ما أجري هذا الفحص أصوم من
+
+112
+00:09:29,740 --> 00:09:36,100
+عشرة لاتناشر ساعة10، 11، 12، في ناس بتصوم تمانية
+
+113
+00:09:36,100 --> 00:09:43,540
+برضه صح انصوم 10 لـ 12 ساعة قبل إجراء الفحص وممنوع
+
+114
+00:09:43,540 --> 00:09:47,920
+في فترة الصوم تشرب كافي أو تشرب .. الأشخاص طبعا
+
+115
+00:09:47,920 --> 00:09:53,140
+بيشربوا كحول لمدة 8 ساعات قبل إجراء الفحص فقط
+
+116
+00:09:53,140 --> 00:09:58,920
+الشغل المسموح فيها أشربهاوانا صايمة الميّه بتصومي
+
+117
+00:09:58,920 --> 00:10:02,000
+عن كل إشي إلا الميّه عادى الميّه مسموح إليك في هذا
+
+118
+00:10:02,000 --> 00:10:06,980
+الفحص تشربيها تمام؟ أي drugs أي أدوية أي
+
+119
+00:10:06,980 --> 00:10:12,400
+medication أنت بتاخدها؟لازم تخبر أخصائي التحليل
+
+120
+00:10:12,400 --> 00:10:18,180
+إنك بتاخد علاج كذا كذا لأنه بخاف هذا العلاج يأثر
+
+121
+00:10:18,180 --> 00:10:23,420
+على نتيجة الفحص Drug medicines inform the person
+
+122
+00:10:23,420 --> 00:10:27,240
+performing the test to omit any medication listed
+
+123
+00:10:27,240 --> 00:10:31,900
+يقولنا إيش بياخد أدوية as undertaking this drug
+
+124
+00:10:31,900 --> 00:10:35,540
+the test result maybe differ ممكن وإنت ممكن هذه
+
+125
+00:10:35,540 --> 00:10:39,810
+الأدوية تأثر على نتيجة الفحصالـ Contraceptive حبوب
+
+126
+00:10:39,810 --> 00:10:44,850
+منع الحمل to be stopped لازم نوقفها one cycle
+
+127
+00:10:44,850 --> 00:10:50,250
+before the performance of the OGTT إذن حبوب منع
+
+128
+00:10:50,250 --> 00:10:54,630
+الحمل برضه بتأثر على هذا الفحص وأدوية أخرى بتأثر
+
+129
+00:10:54,630 --> 00:10:59,210
+عشان هيك هنا ضربوا مثال عشان هيك أي أدوية لازم
+
+130
+00:10:59,210 --> 00:11:02,610
+نحكي فيها ونحكي إنه إحنا بناخد هذا الدواء جاب ال
+
+131
+00:11:02,610 --> 00:11:07,160
+manager الفحص ال test must be performed atdaytime
+
+132
+00:11:07,160 --> 00:11:14,540
+يعني ممكن بأي وقت في اليوم تعمل الفحص يفضل يفضل at
+
+133
+00:11:14,540 --> 00:11:18,760
+the morning في الصباح الباكر تقريبا معاك من الساعة
+
+134
+00:11:18,760 --> 00:11:23,400
+سبعة صباحا لتسعة صباحا في هذا الوقت أفضل وقت من
+
+135
+00:11:23,400 --> 00:11:25,880
+أجل إجراء فحص ال OGTT
+
+136
+00:11:28,620 --> 00:11:32,800
+هل جيتش بحكي ليه؟ test usually takes الفحص بياخد
+
+137
+00:11:32,800 --> 00:11:37,840
+تلات ساعات، تلاتة hours but can last as long as
+
+138
+00:11:37,840 --> 00:11:42,840
+the man كان ياخد ست ساعات معاهم، تمام؟ drink water
+
+139
+00:11:42,840 --> 00:11:47,020
+frequently during the test عادي، ممكن أثناء و أنت
+
+140
+00:11:47,020 --> 00:11:50,660
+بتعمل الفحص خلال التلات ساعات تعود الفحص ممكن تشرب
+
+141
+00:11:50,660 --> 00:11:55,950
+ميه فقط الميه اللي مسموح فيها تشربهاالصحابة الأولى
+
+142
+00:11:55,950 --> 00:12:01,050
+والصحابة الأولى الصحابة الهوائية تتجمد بين الساعة
+
+143
+00:12:01,050 --> 00:12:08,230
+السابعة والتسعة بعد أنك فطرت 12 ساعةهل جيت الكلام
+
+144
+00:12:08,230 --> 00:12:13,490
+اللي موجود بالـ slide نشوف تحت operator gives a
+
+145
+00:12:13,490 --> 00:12:18,070
+test load of glucose usually من 75 لـ 100 جرام من
+
+146
+00:12:18,070 --> 00:12:22,610
+الـ dextrose اللي هو الجلوكوز اندوب بـ 300 أم
+
+147
+00:12:22,610 --> 00:12:28,870
+الواتر أو اندوب باللمون drink the entire solution
+
+148
+00:12:28,870 --> 00:12:34,340
+in 5 minutesهل جيت احنا كلام نسليدات يعني احنا
+
+149
+00:12:34,340 --> 00:12:37,140
+بنشوف ايش بيصير عندنا في غزة في الواقع يعني كيف
+
+150
+00:12:37,140 --> 00:12:41,500
+بنعمل الفحص الفحص عندنا للأمانة بيستغرق two hour
+
+151
+00:12:41,500 --> 00:12:46,380
+فقط ساعتين مش تلاتة ولا ستة تمام بيستغرق ساعتين
+
+152
+00:12:46,380 --> 00:12:51,640
+عشان هيك بيسموه الـ two hour الـ two hour oral
+
+153
+00:12:51,640 --> 00:12:56,900
+glucose tolerance test two hour OGTT هيك اسم الفحص
+
+154
+00:12:56,900 --> 00:13:02,070
+لأنه بيستغرق ساعتينتمام؟ إيش بنحكي للست الحامل؟
+
+155
+00:13:02,070 --> 00:13:07,590
+المهم تيجي لطايمة من 10 إلى 12 ساعة أن التحضيرات
+
+156
+00:13:07,590 --> 00:13:12,570
+الأخرى تاكل carbohydrate وما تعملش exercise، هذه
+
+157
+00:13:12,570 --> 00:13:16,110
+كلها شغلات .. هذه ال standard، شغلات مثلية، بس
+
+158
+00:13:16,110 --> 00:13:19,580
+للأمانةما بتتطبقش عندنا، يعني هذا اللي بيصير عندنا
+
+159
+00:13:19,580 --> 00:13:24,540
+ست حامل، بقولها المرة الجاية بدنا نعملك OGTT، هذا
+
+160
+00:13:24,540 --> 00:13:28,260
+الفحص، تيجيلي أهم إشي صايمة من عشر إلى أتناشر
+
+161
+00:13:28,260 --> 00:13:31,480
+ساعة، تيجي صايمة من عشر إلى أتناشر ساعة، تيجي
+
+162
+00:13:31,480 --> 00:13:37,360
+للمختبر، تمام؟ تجعدأول ما تيجي يفترض أحكي لها معك
+
+163
+00:13:37,360 --> 00:13:41,380
+من الساعة سبعة لساعة تسعة في هذا الواجت في الصباح
+
+164
+00:13:41,380 --> 00:13:45,780
+الباكر أفضل واجت لصحب العينة تجيني وهي صايمة
+
+165
+00:13:45,780 --> 00:13:51,600
+بصحبلها عينة الدم وهذه العينة بشتغللها fasting
+
+166
+00:13:51,600 --> 00:13:57,260
+blood sugar بشتغللها فحص السكر fasting وهي صايمة
+
+167
+00:13:57,260 --> 00:14:01,840
+لأن هي أصلا صايمةإذن أول ما تيجي الست الحامل على
+
+168
+00:14:01,840 --> 00:14:05,360
+المختبر كاينة صايمة عشر ساعات أو تمانية أو اتناش
+
+169
+00:14:05,360 --> 00:14:12,020
+بسحب منها عينةوهذه العينة بشتغللها فحص السكر وهذا
+
+170
+00:14:12,020 --> 00:14:17,320
+الفحص بنسميه fasting blood sugar وبسجل النتيجة
+
+171
+00:14:17,320 --> 00:14:22,460
+بنفس الوقت بقلب منها تروح تجيبلي عينة يورين عشان
+
+172
+00:14:22,460 --> 00:14:27,140
+بالـ strip أشوف في اليورين فيه ثقر ولا لا تمام،
+
+173
+00:14:27,140 --> 00:14:31,860
+هاي نخلص، سحبنا منها عينة دم وأخدنا منها عينة
+
+174
+00:14:31,860 --> 00:14:37,610
+يورينهلجيت بقى أجعد الست على كرسي و بروح أجبلها
+
+175
+00:14:37,610 --> 00:14:44,990
+جرعة سكر هذا السكر إما بدأ مدوب بميه أو مدوب بلمون
+
+176
+00:14:44,990 --> 00:14:50,650
+و بخليها تشربه زي المحلول تشربه عن طريق الفن تمام؟
+
+177
+00:14:52,160 --> 00:14:57,860
+هذا السكر بيحكيلك كميته من خمسة وسبعين لمائة جرام
+
+178
+00:14:57,860 --> 00:15:02,500
+بتوزنيها وزنة بتجيب السكر أو ديكستروز بيجي جاهز
+
+179
+00:15:02,500 --> 00:15:07,500
+طبعا من الشركات من خمسة وسبعين لمائة جرام بتوزني
+
+180
+00:15:07,500 --> 00:15:12,120
+وزنة و بتدوبيهم في تلاتمية قمقة الميه أو في لمون
+
+181
+00:15:12,120 --> 00:15:17,140
+اللي هي ميه بنكهة اللمون عشان تقدر تشربه وبخليها
+
+182
+00:15:17,140 --> 00:15:23,540
+تشربه تمام؟ وبخليها جاعدةلساعتين، بتظل جاعدة
+
+183
+00:15:23,540 --> 00:15:28,060
+لساعتين يعني بعد ما شربت محلول السكر بتظلها جاعدة
+
+184
+00:15:28,060 --> 00:15:35,220
+لساعتين بعد ساعتين بصحب منها عينة وبحلل هذه العينة
+
+185
+00:15:35,220 --> 00:15:39,840
+وبناءً، وبحللها يعني بعمل تحليل السكر عليها وبناءً
+
+186
+00:15:39,840 --> 00:15:45,440
+على نتيجة هذه العينة بقول هذه الست عندها سكر ولا
+
+187
+00:15:45,440 --> 00:15:51,330
+سليمة، تمام؟هذه قليلة الفحص عندنا احنا، هذه قليلة
+
+188
+00:15:51,330 --> 00:15:57,190
+الفحص عندنا احنا لكن شوفوا كلام الـ slides وشوفوا
+
+189
+00:15:57,190 --> 00:16:01,030
+الفحص المثالي اللي عن جد يفترض ينعمل هيك تيجي
+
+190
+00:16:01,030 --> 00:16:05,890
+السيدة صايمة بسحبلها عينة blood و هي صايمة و
+
+191
+00:16:05,890 --> 00:16:09,790
+بعملها فحص ال fasting blood sugar و بطلب منها عينة
+
+192
+00:16:09,790 --> 00:16:15,000
+يورين و بشوف فيها سكر ولا لأ و بجعدها، تمام؟بعد
+
+193
+00:16:15,000 --> 00:16:21,740
+هيك بروح باجبلها المحلول السكري بشربها إياه بعد ما
+
+194
+00:16:21,740 --> 00:16:28,140
+تشرب المحلول السكري بنص ساعة بسحب منها عينة الدم
+
+195
+00:16:28,140 --> 00:16:33,660
+وبشتغللها فحص السكروبعدين بقول هروح ارتاحى بعد
+
+196
+00:16:33,660 --> 00:16:38,700
+كمان نص ساعة بروح كمان أسحب منها عينة و بشتغللها
+
+197
+00:16:38,700 --> 00:16:44,060
+فحص السكر وبعد كمان نص ساعة برضه بسحب منها عينة ال
+
+198
+00:16:44,060 --> 00:16:48,520
+blood و بشتغللها كمان فحص السكر زى ما انتوا شايفين
+
+199
+00:16:48,520 --> 00:16:53,080
+ل blood sample أول واحدة بسحبلها و هي صايمة أول ما
+
+200
+00:16:53,080 --> 00:16:57,700
+توصل مختبر ال fasting blood sugar sample بعطيها
+
+201
+00:16:57,700 --> 00:17:03,930
+جرعة السكروبعد نص ساعة من تناول جرعة السكر بسحبلها
+
+202
+00:17:03,930 --> 00:17:08,390
+عينة تلاتين minutes after oral glucose load يعني
+
+203
+00:17:08,390 --> 00:17:12,750
+بعد ما تاخد جرعة السكر بعد نص ساعة بسحبلها عينة
+
+204
+00:17:12,750 --> 00:17:17,970
+بعدين لما تصير ستين دقيقة بسحبلها عينة يعني كمان
+
+205
+00:17:17,970 --> 00:17:22,770
+نص ساعة تانينولمّا تصير ساعة ونص برضه بسحب لها
+
+206
+00:17:22,770 --> 00:17:27,970
+عينة تالتة ولمّا تصير ساعتين عند الـ120 minute
+
+207
+00:17:27,970 --> 00:17:33,090
+برضه ب .. برضه ب .. برضه ب .. أسحب منها كمان عينة
+
+208
+00:17:33,090 --> 00:17:39,170
+متخيلين عشان أعمل فحص الـ OGTT أكم عينة لازم أحسب
+
+209
+00:17:39,170 --> 00:17:43,290
+.. أسحب من هذه الستيعني تقريبًا خمس عينات، يعني
+
+210
+00:17:43,290 --> 00:17:47,550
+أنا لو بدي أجي أعمل هذا الفحص عند الناس أو هنا في
+
+211
+00:17:47,550 --> 00:17:51,530
+غزة، بدربوني، إيش تسحب مني خمس عينات blood؟ كتير
+
+212
+00:17:51,530 --> 00:17:56,570
+متعب الفحص، فعشان هيك إحنا عندنا اقتصر المسافة
+
+213
+00:17:56,570 --> 00:18:01,130
+Fasting blood sugar أول ما تصل، بحصولها السكر و هي
+
+214
+00:18:01,130 --> 00:18:06,680
+صايمة، بدوها جرعة السكريبعدين بيعطوها جرعة السكر
+
+215
+00:18:06,680 --> 00:18:11,920
+بيخلوها ترتاح وبعد ما ترتاح ساعتين بيصحبوا عينة
+
+216
+00:18:11,920 --> 00:18:17,170
+تانية يعني فعليا بس عينتين دمعينة و هي صايمة و
+
+217
+00:18:17,170 --> 00:18:24,190
+عينة بعد ساعتين من تناول جرعة السكر تمام؟ الـ
+
+218
+00:18:24,190 --> 00:18:28,550
+urine sample بيقول لك كل عينة دم بيسحبولها إياها
+
+219
+00:18:28,550 --> 00:18:32,690
+لازم تروح تجيب معها عينة urine يشتغلوها first
+
+220
+00:18:32,690 --> 00:18:36,950
+fasting urine and hourly collected urine sample
+
+221
+00:18:36,950 --> 00:18:40,290
+يعني أول إشي لما تكون صايمة بيطلبوا عينة urine و
+
+222
+00:18:40,290 --> 00:18:43,880
+بعد هيك كل ساعة بدهم عينة urineانتوا متخيلين الفحص
+
+223
+00:18:43,880 --> 00:18:48,160
+كان بيستغرق 6 ساعات و 3 ساعات كل نص ساعة بيسحب
+
+224
+00:18:48,160 --> 00:18:51,480
+عينا من الست كل نص ساعة بيسحب عينا من الست وهذا
+
+225
+00:18:51,480 --> 00:18:55,840
+كتير مجهد و .. و .. و بتعب نفسيت المريض، تمام؟
+
+226
+00:18:57,830 --> 00:19:01,810
+هلجيت بس بدي أحكي عن الـ Normal Range اللي خاص
+
+227
+00:19:01,810 --> 00:19:05,130
+بالـ Two Hour Oral Glucose Tolerance Test عندنا
+
+228
+00:19:05,130 --> 00:19:09,630
+بغزا لو بعد ساعتين يعني بعد ما أعطيتك جرعة السكر
+
+229
+00:19:09,630 --> 00:19:14,170
+تمام بعد ساعتين لما أجي أعملك فحص السكر إذا طلع
+
+230
+00:19:14,170 --> 00:19:18,730
+سكرك 110 milligram per deciliter أو أقل هذا إنسان
+
+231
+00:19:18,730 --> 00:19:24,040
+Normalبين 140 لـ 200 ميلي جرام per deciliter هذا
+
+232
+00:19:24,040 --> 00:19:28,000
+إنسان pre-diabetic يعني عنده risk factor للمستقبل
+
+233
+00:19:28,000 --> 00:19:33,940
+إنه ينصب بمرض السكري لو طلع سكرا 200 ميلي جرام per
+
+234
+00:19:33,940 --> 00:19:38,260
+deciliter أو أعلى من 200 هذا بيكون مؤكد diabetic
+
+235
+00:19:38,260 --> 00:19:43,170
+إنسان مريض سكرياللي أمامنا جدول أكيد مش حفظ بس
+
+236
+00:19:43,170 --> 00:19:48,450
+بدنا نفهم و نفهم Calculation بظهرلك كل عالم كيف
+
+237
+00:19:48,450 --> 00:19:53,410
+كان بيشتغل فحص الـ OGTT لأنه كل عالم استخدم طريقة
+
+238
+00:19:53,410 --> 00:19:59,190
+مختلفة لشغل الـ OGTT وبرضه تحليل نتيجة الـ OGTT
+
+239
+00:19:59,190 --> 00:20:05,150
+برضه مختلفة من عالم لعالم، تمام؟هلجيت عندنا و الـ
+
+240
+00:20:05,150 --> 00:20:08,690
+Carson criteria العالم و الـ Carson كيف اشتغل الـ
+
+241
+00:20:08,690 --> 00:20:13,210
+OGTT و كيف حلل النتيجة جالب تيجي السيد صايمة
+
+242
+00:20:13,210 --> 00:20:17,170
+fasting تمام و بيسحب منها عينة و بيشتغللها فحص
+
+243
+00:20:17,170 --> 00:20:23,030
+السكر fasting blood sugarلو طلع سكرها 130 أو أعلى
+
+244
+00:20:23,030 --> 00:20:28,130
+من 130 بأعطيها 1 point بأعطيها درجة طيب لو سكرها
+
+245
+00:20:28,130 --> 00:20:32,850
+كان أقل من 130 بيعطيها صفر يعني مافيش إلها ولا
+
+246
+00:20:32,850 --> 00:20:37,690
+درجة بعدين بيعطيها المحلول السكري بعد نص ساعة ما
+
+247
+00:20:37,690 --> 00:20:41,630
+بيسحبلها دم هي حاطة شحتة يعني ما بيسحبلها دم بعد
+
+248
+00:20:41,630 --> 00:20:46,690
+ساعة من إعطاءها محلول السكر بيسحبلها دم لو طلع
+
+249
+00:20:46,690 --> 00:20:52,440
+أعلى من 190أذا بأعطيها نص درجة أقل من 190
+
+250
+00:20:52,440 --> 00:20:56,280
+milligram per deciliter صفر بأعطيها شوية درجة ع
+
+251
+00:20:56,280 --> 00:21:00,500
+الساعة و نص يعني ع 90 minutes ما ساحبلها ع
+
+252
+00:21:00,500 --> 00:21:05,930
+الساعتين يعني ع ال 120 minutes ساحبلهاوفحصها لو
+
+253
+00:21:05,930 --> 00:21:10,810
+طلع دمها أكتر من سكر الدم أكتر من 140 milligram
+
+254
+00:21:10,810 --> 00:21:14,970
+per deciliter بعطيها نص point، نص درجة أقل من 140
+
+255
+00:21:14,970 --> 00:21:18,930
+ما بيعطيها ولا درجة سفر ع الساعتين ونص برضه
+
+256
+00:21:18,930 --> 00:21:23,130
+بيسحبلها عينة دم أخرى طلعت أكتر من 130 milligram
+
+257
+00:21:23,130 --> 00:21:27,450
+per deciliter بعطيها point أقل من 130 ما بيعطيها
+
+258
+00:21:27,450 --> 00:21:31,390
+ولا point سفرالـ Result في الآخر بيقولّك بيجمع ال
+
+259
+00:21:31,390 --> 00:21:35,010
+points بيجمع النقاط لو طلعت من اتنين لتلاتة point
+
+260
+00:21:35,010 --> 00:21:39,350
+بتكون هذه ال 6 diabetic لو طلع مجموع نقاطها من نص
+
+261
+00:21:39,350 --> 00:21:42,770
+لواحد و نص point بتكون Suspected يعني Pre-diabetic
+
+262
+00:21:42,770 --> 00:21:48,050
+لو طلعوا مجموع النقاط Zero معناها Non-diabetic هنا
+
+263
+00:21:48,050 --> 00:21:53,370
+لو جمعناهي نقطة، نقطين و نص ذائب نص، نقطة يعني هاي
+
+264
+00:21:53,370 --> 00:21:57,850
+تلاتة point تلاتة point صنفهم ضيابتك أما إيجي عالم
+
+265
+00:21:57,850 --> 00:22:02,710
+آخر Vajankund criteria الست بتكون okay صايمة لكن
+
+266
+00:22:02,710 --> 00:22:06,830
+ما بيسحبلها عينة و هي صايمة وبعطيها جرعة السكر ما
+
+267
+00:22:06,830 --> 00:22:10,010
+بيسحبلها عينة على التلاتين minute بيسحبلها عينة
+
+268
+00:22:10,010 --> 00:22:13,600
+على الساعةعالـ 60 minutes يعني بعد ما يعطيها جرعة
+
+269
+00:22:13,600 --> 00:22:18,780
+السكر بساعة لو طلعت أعلى من 190 بعطيها plus 1 أقل
+
+270
+00:22:18,780 --> 00:22:23,160
+من 190 بعطيها صفر وعالساعة و نص يعني عالـ 90
+
+271
+00:22:23,160 --> 00:22:28,320
+minutes برضه بحسبلها و بسحبلها عينة و بحسب نسبة
+
+272
+00:22:28,320 --> 00:22:33,740
+السكر فيها أعلى من 165 بعطيها plus 1 أقل من 165
+
+273
+00:22:33,740 --> 00:22:39,140
+بعطيها صفر عالساعتين يعني عالـ 120 minutes برضه
+
+274
+00:22:39,140 --> 00:22:44,360
+بسحبلها كمان عينةطلع السكر أعلى من 140 بيعطيها
+
+275
+00:22:44,360 --> 00:22:49,460
+plus 1 أجل من 140 بيعطيها صفر point في الآخر بيجمع
+
+276
+00:22:49,460 --> 00:22:54,920
+النقاط لو طلعت تلاتة مجموعهم إذا هي ضيبتك من 1 ل 2
+
+277
+00:22:54,920 --> 00:22:59,980
+suspect إذا مافيش كل صفر إذا ما ضيبتك هنا تلاتة
+
+278
+00:22:59,980 --> 00:23:04,620
+مجموعهم plus 1 plus 1 plus 1 إذا هي ضيبتك آخر عالم
+
+279
+00:23:04,620 --> 00:23:09,720
+revised some nationهذا العالم إيش قال تي جستت
+
+280
+00:23:09,720 --> 00:23:13,240
+بيعمللها الفحص و هي صايمة F معناها fasting blood
+
+281
+00:23:13,240 --> 00:23:17,280
+sugar تمام و هي صايمة بيعمللها الفحص و بيسجل ال
+
+282
+00:23:17,280 --> 00:23:22,880
+result تبعت السكروبروح ع الساعة بعدين بيعطيها جرعة
+
+283
+00:23:22,880 --> 00:23:26,600
+السكر بعد ساعة من إعطاءها محلول السكري يعني ع
+
+284
+00:23:26,600 --> 00:23:31,560
+الـ60 دقيقة بيسحبلها عينة و بعد ساعة و نص يعني ع
+
+285
+00:23:31,560 --> 00:23:36,180
+الـ90 دقيقة برضه بيسحبلها عينة وع الـ120 دقيقة
+
+286
+00:23:36,180 --> 00:23:40,840
+يعني بعد ساعتين برضه بيسحبلها عينةوفي كل مرة
+
+287
+00:23:40,840 --> 00:23:45,080
+بيفحصلها مستوى السكر نسبة السكر في الدم هالجيت ال
+
+288
+00:23:45,080 --> 00:23:50,560
+results النتيجة يعني وهي صايمة وع الساعة وع الساعة
+
+289
+00:23:50,560 --> 00:23:55,400
+ونصف وع الساعتين ال results تبعت السكر نسب السكر
+
+290
+00:23:55,400 --> 00:23:59,940
+بيروحوا هو جمعهم عامل لهم summation مثلا طلع السكر
+
+291
+00:23:59,940 --> 00:24:05,520
+عندي 120 المرة التانية 105، 200، 300، بجمع هذه
+
+292
+00:24:05,520 --> 00:24:12,850
+الأرقامتمام؟ ولو طلع مجموع السكر فيه هاديفي الـ
+
+293
+00:24:12,850 --> 00:24:15,850
+Fasting و الـ 60 Minutes و الـ 90 Minutes و الـ
+
+294
+00:24:15,850 --> 00:24:19,450
+120 Minutes لو طلع مجموع السكر أعلى من 600
+
+295
+00:24:19,450 --> 00:24:22,770
+Milligrams per deciliter إذا الست بتكون Diabetic
+
+296
+00:24:22,770 --> 00:24:27,110
+لو الـ Summation لنسب السكر كانت أجل من 600
+
+297
+00:24:27,110 --> 00:24:30,290
+Milligrams per deciliter إذا هي Non-Diabetic
+
+298
+00:24:30,290 --> 00:24:35,150
+نستنتج من هنا طبعا لا بدنا نحفظ ولا بدنا نعرف إشي
+
+299
+00:24:35,150 --> 00:24:39,890
+بس أهم إشي نفهم إن كل عالم كانت طريقة شغله للفحص
+
+300
+00:24:39,890 --> 00:24:44,170
+مختلفةوالـ Interpretation برضه للنتائج وتحليله
+
+301
+00:24:44,170 --> 00:24:51,150
+للنتائج برضه كانت مختلفة، واتحط «إنسلين ليفنز
+
+302
+00:24:51,150 --> 00:24:54,230
+اكسبلين دا جيلوكوس توليرانس كيرف» هذا ال curve
+
+303
+00:24:54,230 --> 00:24:57,890
+already احنا يا جماعة حكيناه قبل، هذا ال curve
+
+304
+00:24:57,890 --> 00:25:02,230
+اسمه tolerance curve لإنسان سليم اللي جسمه بيقدر
+
+305
+00:25:02,230 --> 00:25:06,470
+يتعامل مع جرعة السكر اللي بياخدهااللون البنفسجي،
+
+306
+00:25:06,470 --> 00:25:10,530
+الـ Move هو خط الإنسولين واللون الأخضر هو خط
+
+307
+00:25:10,530 --> 00:25:16,050
+الجلوكوز هلجيت لو جينا على الـ Y-axis عند 90 ميلي
+
+308
+00:25:16,050 --> 00:25:19,850
+جرام per deciliter هذه نسبة السكر عند الإنسان
+
+309
+00:25:19,850 --> 00:25:23,530
+الطبيعي، احنا حكينا من 70 ل110، هو طالع عنده 90
+
+310
+00:25:23,530 --> 00:25:28,310
+هلجيت لو روحت أنا أعطيته جرعة سكر، إيش بتتخيلوا
+
+311
+00:25:28,310 --> 00:25:33,190
+المنحنى الأخضر هيصير، هيرتفع؟ يعني سكره هيزيد في
+
+312
+00:25:33,190 --> 00:25:38,170
+الدم، تمام، هيزادفي المقابل، لما السكر يزيد في
+
+313
+00:25:38,170 --> 00:25:42,650
+الدم، كمان الإنسولين بدي يزيد، هاي الخط البنفسجي
+
+314
+00:25:42,650 --> 00:25:46,310
+زاد، هاي الأثنين زادوا مع بعض، ليش الإنسولين زاد؟
+
+315
+00:25:46,310 --> 00:25:51,030
+عشان بدي يبدأ يخفض من مستوى السكر، عند حد معين،
+
+316
+00:25:51,030 --> 00:25:55,030
+شوفوا الـcurve الأخضر، إيش صار فيه؟ الخط الأخضر
+
+317
+00:25:55,030 --> 00:26:00,210
+نزل، معناه السكر بدأ ينزل، ليش؟ لأن الإنسولين خفضه
+
+318
+00:26:00,700 --> 00:26:05,500
+لما السكر بدأ يجل و تمام برضه الإنسولين بدي يبدأ
+
+319
+00:26:05,500 --> 00:26:10,980
+يجل عشان فيش إشي دلّه مرتفع إذا الإنسولين خفض
+
+320
+00:26:10,980 --> 00:26:15,560
+السكر هي الـ curve الأخضر بدأ ينزل و لما نزل السكر
+
+321
+00:26:15,560 --> 00:26:21,280
+برضه بدأ الإنسولين خلاص بدأ الإنسولين ينخفض و بطل
+
+322
+00:26:21,280 --> 00:26:27,280
+ينفرز لأن السكر انخفضتمام؟ هذا اللي بدنا نفهمه من
+
+323
+00:26:27,280 --> 00:26:32,520
+الرسمة لو قرأنا المربعات اللي لونهم Orange Rising
+
+324
+00:26:32,520 --> 00:26:36,260
+blood glucose stimulate insulin production ارتفاع
+
+325
+00:26:36,260 --> 00:26:40,920
+مستوى السكر أدى إلى زيادة مستوى الإنسلين في الدم
+
+326
+00:26:40,920 --> 00:26:46,500
+High level من الإنسلين لما زاد الإنسلينسبب drop in
+
+327
+00:26:46,500 --> 00:26:51,320
+blood glucose سبب انخفاض في مستوى السكر as a
+
+328
+00:26:51,320 --> 00:26:57,300
+glucose level لما مستوى السكر انخفض there is less
+
+329
+00:26:57,300 --> 00:27:01,360
+stimulation for insulin production بطل في عنا حافظ
+
+330
+00:27:01,360 --> 00:27:06,060
+للانسولين يظل عالي وموجود في الدم and insulin drop
+
+331
+00:27:06,060 --> 00:27:10,860
+برضه الانسولين انخفضوالـ Insulin level returned to
+
+332
+00:27:10,860 --> 00:27:15,100
+normal بعد هيك خلاص رجع الإنسولين لتركيزه الطبيعي
+
+333
+00:27:15,100 --> 00:27:21,120
+الجليكوز بدأ يرتفع بشكل تدريجي لحد ما يصل لوضعه
+
+334
+00:27:21,120 --> 00:27:25,040
+الطبيعي اللي بدنا نفهمه أن الأتنين بيرتفعوا مع بعض
+
+335
+00:27:25,040 --> 00:27:30,480
+والأتنين بنخفضوا مع بعض، تمام؟لأنه لو ارتفع السكر،
+
+336
+00:27:30,480 --> 00:27:34,960
+هيزيد الإنسولين عشان يخفض السكر، ولو جل السكر
+
+337
+00:27:34,960 --> 00:27:39,580
+وانخفض خلاص الإنسولين خلص دوره، برضه هينخفض ويرجع
+
+338
+00:27:39,580 --> 00:27:45,250
+لوضعه الطبيعيهلجيت يا جماعة؟ بدنا نحكيكوا عن الـ
+
+339
+00:27:45,250 --> 00:27:49,350
+Normal Range نحكي و بعدين نشوف الـ Slides بما يخص
+
+340
+00:27:49,350 --> 00:27:53,670
+فحص ان الـ Two Hour Oral Glucose Tolerance Test
+
+341
+00:27:53,670 --> 00:27:59,270
+الوضع الطبيعي لو طلع الشخص سكره 110 milligram per
+
+342
+00:27:59,270 --> 00:28:04,870
+deciliter أو أقل إذا هذا إنسان Normal وسليمطيب لو
+
+343
+00:28:04,870 --> 00:28:10,690
+طلع السكر عنده من 140 ل 200 في هذا الـ range من
+
+344
+00:28:10,690 --> 00:28:15,690
+140 ل 200 milligram per deciliter هذا pre-diabetic
+
+345
+00:28:15,690 --> 00:28:19,190
+الـ pre-diabetic يعني عنده risk factor في المستقبل
+
+346
+00:28:19,190 --> 00:28:25,720
+للإصابة بالسكرلو طلع سكره 200 أو أعلى من 200 فهذا
+
+347
+00:28:25,720 --> 00:28:31,380
+أكيد Diabetic هذه الـ Normal Range الصحيحة والخاصة
+
+348
+00:28:31,380 --> 00:28:37,250
+بفحص الـ Oral Glucose Tolerance Test تمام؟أما
+
+349
+00:28:37,250 --> 00:28:42,570
+بالنسبة للـ Normal Range الخاصة بأول فحص أخدناه
+
+350
+00:28:42,570 --> 00:28:46,770
+الـ Fasting Blood Sugar تمام؟ هذا الفحص اللي احنا
+
+351
+00:28:46,770 --> 00:28:53,030
+كلنا بنعمله الوضع الطبيعي من 70 ل110 milligram per
+
+352
+00:28:53,030 --> 00:28:59,720
+deciliterلكن هذا إنسان Normal لكن لو طلع من 110 لـ
+
+353
+00:28:59,720 --> 00:29:04,500
+126 milligram per deciliter هذا بيكون pre-diabetic
+
+354
+00:29:04,500 --> 00:29:11,440
+لو طلع السكر 126 أو أعلى هذا بيكون إنسان أكيد
+
+355
+00:29:11,440 --> 00:29:15,120
+ضيابتك وأكيد مريض سكري مابتناش اللخبط بين
+
+356
+00:29:15,120 --> 00:29:20,560
+الـNormal Range الخاصة بفحص الـ OGTT والخاصة بفحص
+
+357
+00:29:20,560 --> 00:29:26,690
+ال fasting blood sugar تمام؟نشوف أول نقطة باللون
+
+358
+00:29:26,690 --> 00:29:31,170
+الأحمر Normal Response هنا جزده الـ Normal Range
+
+359
+00:29:31,170 --> 00:29:36,110
+الخاصة بالـ Oral Glucose Tolerance Test a person
+
+360
+00:29:36,110 --> 00:29:39,690
+is said to have a normal response when the two
+
+361
+00:29:39,690 --> 00:29:43,650
+-hour glucose level is less than or equal to 110
+
+362
+00:29:43,650 --> 00:29:48,110
+milligram per deciliter، هذا الوضع الطبيعيللإنسان
+
+363
+00:29:48,110 --> 00:29:52,510
+الطبيعي لو عملتله فحص الـ OGTT بدي يطلع السكر عنده
+
+364
+00:29:52,510 --> 00:29:58,910
+110 أو أقل عشان أقدر أحكي عنه طبيعي أما النقطة
+
+365
+00:29:58,910 --> 00:30:03,030
+التالتة سيبوني من النقطة التانيةالنقطة التالتة
+
+366
+00:30:03,030 --> 00:30:07,150
+بتقولّي «embarred glucose tolerance» كلمة
+
+367
+00:30:07,150 --> 00:30:12,810
+«embarred» معناه يعني فيه خلل، فيه مشكلة ممكن أحكي
+
+368
+00:30:12,810 --> 00:30:16,930
+عنها الـpre-diabetic، تمام؟ «embarred» معناه خلل
+
+369
+00:30:16,930 --> 00:30:23,080
+أو مشكلة في الـglucose tolerance«الشخص يعتمد لديه
+
+370
+00:30:23,080 --> 00:30:27,540
+تحرير الجلوكوز» متى بقول عن هذا الشخص عنده تحرير
+
+371
+00:30:27,540 --> 00:30:32,080
+عنده مشكلة في الجلوكوز توليرانس ‏when the two our
+
+372
+00:30:32,080 --> 00:30:36,340
+glucose results from the oral glucose tolerance
+
+373
+00:30:36,340 --> 00:30:41,040
+test are greater than or equal مية وأربعين
+
+374
+00:30:47,580 --> 00:30:52,640
+لو اعملت لشخص فحص الـ Orange Glucose Tolerance
+
+375
+00:30:52,640 --> 00:30:57,900
+Test تمام؟ وبعد ما أعطيته جرعة السكر بساعتين
+
+376
+00:30:57,900 --> 00:31:05,230
+فحصتله السكرطلعت النتيجة ما بين الـ140 للـ200 يعني
+
+377
+00:31:05,230 --> 00:31:10,510
+بهذه الحدود Range ما بين الـ140 والـ200 milligram
+
+378
+00:31:10,510 --> 00:31:14,770
+per deciliter بحكي عن هذا الشخص الـpre-diabetic
+
+379
+00:31:14,770 --> 00:31:19,310
+إيش يعني pre-diabetic؟ يعني هو عنده Emberged عنده
+
+380
+00:31:19,310 --> 00:31:24,460
+خلل، عنده مشكلة، عنده risk factorللإصابة بالسكري
+
+381
+00:31:24,460 --> 00:31:28,600
+في المستقبل فتعطيه حمية تقوليله العب، exercise، ما
+
+382
+00:31:28,600 --> 00:31:32,760
+تاكلش أكلات لأنه احتمال في المستقبل يصير عندك سكري
+
+383
+00:31:32,760 --> 00:31:38,300
+أما النقطة اللي في النص Embered fasting glucose
+
+384
+00:31:38,300 --> 00:31:43,920
+بيقصد فيها فحص ال fasting blood sugar اللي أخدناه
+
+385
+00:31:43,920 --> 00:31:50,130
+أول مرةwhen a person has fasting glucose equal to
+
+386
+00:31:50,130 --> 00:31:56,210
+or greater than 110 and less than 126. This is
+
+387
+00:31:56,210 --> 00:32:00,070
+considered a risk factor for future diabetes. هذا
+
+388
+00:32:00,070 --> 00:32:05,010
+الإنسان اللي جيت عملتله fasting blood sugar وطلع
+
+389
+00:32:05,010 --> 00:32:10,710
+ما بين 110 و126 milligram per deciliter، هذا بقول
+
+390
+00:32:10,710 --> 00:32:15,570
+عنه pre-diabetic، بقول عنه impaired.إذاً كل فحصية
+
+391
+00:32:15,570 --> 00:32:22,130
+جماعة
+اللي لديها عدد عادل خاص فيه آخر slide
+
+392
+00:32:22,130 --> 00:32:28,850
+الـDiabetes هذا الـNormal Range الخاص في الـOGTT
+
+393
+00:32:28,850 --> 00:32:33,450
+إذا كان شخص يمتلك الـDiabetes وإن أمر الجلوكوز
+
+394
+00:32:33,450 --> 00:32:38,370
+توليرانس تست شهر إن مستوى جلوكوز الدم
+في ساعات هو
+
+395
+00:32:38,370 --> 00:32:44,150
+أكتر من 200 ملي جرام في ديسليتر لو شخصبعد ساعتين
+
+396
+00:32:44,150 --> 00:32:49,930
+من إعطاءه جرعة السكر عملتله فحص الـ OGTT ولجات
+
+397
+00:32:49,930 --> 00:32:55,670
+سكره 200 فم فوق إذا هو أكيد مريض سكري وهو
+
+398
+00:32:55,670 --> 00:33:01,040
+Diabetes، تمام؟أخر حاجة الـ gestational diabetes
+
+399
+00:33:01,040 --> 00:33:07,840
+اللي هو سكر الحمل gestational diabetes سكر الحمل a
+
+400
+00:33:07,840 --> 00:33:12,640
+woman has gestational diabetes when she is
+
+401
+00:33:12,640 --> 00:33:17,020
+pregnant and has any two of the following هذا سكر
+
+402
+00:33:17,020 --> 00:33:21,920
+الحمل طبعاً بصيب الستات أكيد الحوامل أثناء فترة
+
+403
+00:33:21,920 --> 00:33:26,870
+الحملand has any two of the following يعني الست
+
+404
+00:33:26,870 --> 00:33:33,370
+الحامل بتقولك بيكون عندها واحدة من هدول الشغلاتلما
+
+405
+00:33:33,370 --> 00:33:38,710
+بدك تعمليلها OGTT الـ 6 الحامل لو طلع عندها الـ
+
+406
+00:33:38,710 --> 00:33:42,310
+fasting blood sugar اللي هي و هي ثايمة لسه و
+
+407
+00:33:42,310 --> 00:33:46,330
+سحبتيلها العينة و طلع ال fasting blood sugar أعلى
+
+408
+00:33:46,330 --> 00:33:52,070
+من 105 و بعد هي أعطتيها جرعة السكر و خلتيها تنتظر
+
+409
+00:33:52,070 --> 00:33:57,890
+ساعة و بعد ساعة حللتيلها السكر و طلع أعلى من 190
+
+410
+00:33:57,890 --> 00:34:05,060
+بقدر أحكي أنه عندها سكر حملأو لو إجت ست حامل
+
+411
+00:34:05,060 --> 00:34:10,760
+وأعطتيها جرعة سكر بعد ساعتين من تناول جرعة السكر
+
+412
+00:34:10,760 --> 00:34:18,600
+لجيت سكرها أعلى من 165 وبعد 3 ساعات سحبت منها عينة
+
+413
+00:34:18,600 --> 00:34:23,900
+ولجيت سكرها أعلى من 145 برضه هي بتكون عندها
+
+414
+00:34:25,000 --> 00:34:30,420
+Gestational Diabetes طبعا يا جماعة ما يخص
+
+415
+00:34:30,420 --> 00:34:33,560
+الـGestational Diabetes فقط بدي أكوا تعرفوا أنه
+
+416
+00:34:33,560 --> 00:34:37,980
+سكر حمل بصيب الستات وهي حوامل أما الـNormal Range
+
+417
+00:34:37,980 --> 00:34:43,720
+اللي توحكته هذا مش مطلوب بالنسبة لسكر الحمل مش
+
+418
+00:34:43,720 --> 00:34:48,700
+مطلوب تمام؟ لأن كل مختبر له Normal Range خاص فيه
+
+419
+00:34:48,700 --> 00:34:52,400
+تمام؟
+
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/a3GO5ndJhG8_raw.json b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/a3GO5ndJhG8_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..c1e6fd2e6c811460282e9b5320f2b035f4e919c6
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/a3GO5ndJhG8_raw.json
@@ -0,0 +1 @@
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"end": 1194.21, "word": " مختلفة", "probability": 0.9892578125}, {"start": 1194.21, "end": 1194.89, "word": " لشغل", "probability": 0.987060546875}, {"start": 1194.89, "end": 1195.17, "word": " الـ", "probability": 0.91650390625}, {"start": 1195.17, "end": 1195.83, "word": " OGTT", "probability": 0.979248046875}, {"start": 1195.83, "end": 1197.27, "word": " وبرضه", "probability": 0.8819580078125}, {"start": 1197.27, "end": 1197.91, "word": " تحليل", "probability": 0.977783203125}, {"start": 1197.91, "end": 1198.43, "word": " نتيجة", "probability": 0.9940185546875}, {"start": 1198.43, "end": 1198.63, "word": " الـ", "probability": 0.870849609375}, {"start": 1198.63, "end": 1199.19, "word": " OGTT", "probability": 0.9853515625}, {"start": 1199.19, "end": 1199.73, "word": " برضه", "probability": 0.9375}, {"start": 1199.73, "end": 1200.29, "word": " مختلفة", "probability": 0.992919921875}, {"start": 1200.29, "end": 1200.43, "word": " من", "probability": 0.990234375}, {"start": 1200.43, "end": 1200.81, "word": " عالم", "probability": 0.99267578125}, {"start": 1200.81, "end": 1201.79, "word": " لعالم،", "probability": 0.883056640625}, {"start": 1201.79, "end": 1202.37, "word": " تمام؟", "probability": 0.9783528645833334}], "temperature": 1.0}, {"id": 56, "seek": 121893, "start": 1203.41, "end": 1218.93, "text": "هلجيت عندنا و الـ Carson criteria العالم و الـ Carson كيف اشتغل الـ OGTT و كيف حلل النتيجة جالب تيجي السيد صايمة fasting تمام و بيسحب منها عينة و بيشتغللها فحص السكر fasting blood sugar", "tokens": [3224, 1211, 7435, 36081, 43242, 8315, 4032, 2423, 39184, 38731, 11101, 18863, 45340, 4032, 2423, 39184, 38731, 9122, 33911, 1975, 8592, 2655, 17082, 1211, 2423, 39184, 32477, 28178, 4032, 9122, 33911, 11331, 1211, 1211, 28239, 31371, 7435, 3660, 10874, 6027, 3555, 6055, 1829, 7435, 1829, 21136, 25708, 20328, 995, 32640, 3660, 22371, 46811, 10943, 4032, 4724, 1829, 3794, 5016, 3555, 9154, 11296, 6225, 9957, 3660, 4032, 4724, 1829, 8592, 2655, 17082, 1211, 1211, 11296, 6156, 5016, 9381, 21136, 37983, 22371, 3390, 5076], "avg_logprob": -0.22533885398543024, "compression_ratio": 1.5567567567567568, "no_speech_prob": 0.0, "words": [{"start": 1203.41, "end": 1204.07, "word": "هلجيت", "probability": 0.61859130859375}, {"start": 1204.07, "end": 1204.71, "word": " عندنا", "probability": 0.713623046875}, {"start": 1204.71, "end": 1204.87, "word": " و", "probability": 0.54296875}, {"start": 1204.87, "end": 1205.15, "word": " الـ", "probability": 0.4764404296875}, {"start": 1205.15, "end": 1205.53, "word": " Carson", "probability": 0.2301025390625}, {"start": 1205.53, "end": 1206.37, "word": " criteria", "probability": 0.208984375}, {"start": 1206.37, "end": 1206.97, "word": " العالم", "probability": 0.88720703125}, {"start": 1206.97, "end": 1207.09, "word": " و", "probability": 0.8564453125}, {"start": 1207.09, "end": 1207.27, "word": " الـ", "probability": 0.8525390625}, {"start": 1207.27, "end": 1207.65, "word": " Carson", "probability": 0.74658203125}, {"start": 1207.65, "end": 1208.07, "word": " كيف", "probability": 0.97509765625}, {"start": 1208.07, "end": 1208.49, "word": " اشتغل", "probability": 0.9189453125}, {"start": 1208.49, "end": 1208.69, "word": " الـ", "probability": 0.844970703125}, {"start": 1208.69, "end": 1209.27, "word": " OGTT", "probability": 0.800537109375}, {"start": 1209.27, "end": 1209.57, "word": " و", "probability": 0.91357421875}, {"start": 1209.57, "end": 1209.91, "word": " كيف", "probability": 0.86328125}, {"start": 1209.91, "end": 1210.41, "word": " حلل", "probability": 0.89453125}, {"start": 1210.41, "end": 1211.27, "word": " النتيجة", "probability": 0.9603271484375}, {"start": 1211.27, "end": 1212.03, "word": " جالب", "probability": 0.7067057291666666}, {"start": 1212.03, "end": 1212.31, "word": " تيجي", "probability": 0.95654296875}, {"start": 1212.31, "end": 1212.65, "word": " السيد", "probability": 0.595703125}, {"start": 1212.65, "end": 1213.21, "word": " صايمة", "probability": 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"probability": 0.92431640625}, {"start": 1218.55, "end": 1218.93, "word": " sugar", "probability": 0.884765625}], "temperature": 1.0}, {"id": 57, "seek": 124777, "start": 1219.45, "end": 1247.77, "text": "لو طلع سكرها 130 أو أعلى من 130 بأعطيها 1 point بأعطيها درجة طيب لو سكرها كان أقل من 130 بيعطيها صفر يعني مافيش إلها ولا درجة بعدين بيعطيها المحلول السكري بعد نص ساعة ما بيسحبلها دم هي حاطة شحتة يعني ما بيسحبلها دم بعد ساعة من إعطاءها محلول السكر بيسحبلها دم لو طلع أعلى من 190", "tokens": [1211, 2407, 23032, 1211, 3615, 8608, 37983, 11296, 19966, 34051, 5551, 3615, 23942, 9154, 19966, 4724, 10721, 3615, 9566, 1829, 11296, 502, 935, 4724, 10721, 3615, 9566, 1829, 11296, 11778, 47341, 3660, 23032, 1829, 3555, 45164, 8608, 37983, 11296, 25961, 5551, 4587, 1211, 9154, 19966, 4724, 1829, 3615, 9566, 1829, 11296, 20328, 5172, 2288, 37495, 22653, 19446, 41185, 8592, 11933, 1211, 11296, 49429, 11778, 47341, 3660, 39182, 9957, 4724, 1829, 3615, 9566, 1829, 11296, 9673, 5016, 1211, 12610, 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{"start": 1222.57, "end": 1223.03, "word": " أعلى", "probability": 0.955078125}, {"start": 1223.03, "end": 1223.23, "word": " من", "probability": 0.9921875}, {"start": 1223.23, "end": 1223.97, "word": " 130", "probability": 0.84619140625}, {"start": 1223.97, "end": 1224.85, "word": " بأعطيها", "probability": 0.8056233723958334}, {"start": 1224.85, "end": 1225.17, "word": " 1", "probability": 0.60693359375}, {"start": 1225.17, "end": 1225.61, "word": " point", "probability": 0.85498046875}, {"start": 1225.61, "end": 1226.17, "word": " بأعطيها", "probability": 0.8983154296875}, {"start": 1226.17, "end": 1226.67, "word": " درجة", "probability": 0.9943033854166666}, {"start": 1226.67, "end": 1227.45, "word": " طيب", "probability": 0.9527994791666666}, {"start": 1227.45, "end": 1227.59, "word": " لو", "probability": 0.69287109375}, {"start": 1227.59, "end": 1228.13, "word": " سكرها", "probability": 0.98291015625}, {"start": 1228.13, "end": 1228.43, "word": " كان", "probability": 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بيعطيها", "probability": 0.9228515625}, {"start": 1234.65, "end": 1235.17, "word": " المحلول", "probability": 0.988525390625}, {"start": 1235.17, "end": 1235.77, "word": " السكري", "probability": 0.9597981770833334}, {"start": 1235.77, "end": 1236.39, "word": " بعد", "probability": 0.97802734375}, {"start": 1236.39, "end": 1236.83, "word": " نص", "probability": 0.964599609375}, {"start": 1236.83, "end": 1237.25, "word": " ساعة", "probability": 0.9876302083333334}, {"start": 1237.25, "end": 1237.69, "word": " ما", "probability": 0.89453125}, {"start": 1237.69, "end": 1238.35, "word": " بيسحبلها", "probability": 0.9091796875}, {"start": 1238.35, "end": 1238.59, "word": " دم", "probability": 0.987548828125}, {"start": 1238.59, "end": 1238.83, "word": " هي", "probability": 0.837890625}, {"start": 1238.83, "end": 1239.17, "word": " حاطة", "probability": 0.70361328125}, {"start": 1239.17, "end": 1239.61, "word": " شحتة", "probability": 0.86865234375}, {"start": 1239.61, "end": 1239.83, "word": " يعني", "probability": 0.918701171875}, {"start": 1239.83, "end": 1240.03, "word": " ما", "probability": 0.9404296875}, {"start": 1240.03, "end": 1240.59, "word": " بيسحبلها", "probability": 0.9608561197916666}, {"start": 1240.59, "end": 1240.89, "word": " دم", "probability": 0.992919921875}, {"start": 1240.89, "end": 1241.63, "word": " بعد", "probability": 0.95458984375}, {"start": 1241.63, "end": 1242.15, "word": " ساعة", "probability": 0.99072265625}, {"start": 1242.15, "end": 1242.35, "word": " من", "probability": 0.99267578125}, {"start": 1242.35, "end": 1243.01, "word": " إعطاءها", "probability": 0.87919921875}, {"start": 1243.01, "end": 1243.51, "word": " محلول", "probability": 0.9869384765625}, {"start": 1243.51, "end": 1244.13, "word": " السكر", "probability": 0.975341796875}, {"start": 1244.13, "end": 1245.19, "word": " بيسحبلها", "probability": 0.9837239583333334}, {"start": 1245.19, "end": 1245.75, "word": " دم", "probability": 0.993896484375}, {"start": 1245.75, "end": 1246.39, "word": " لو", "probability": 0.93994140625}, {"start": 1246.39, "end": 1246.69, "word": " طلع", "probability": 0.9938151041666666}, {"start": 1246.69, "end": 1246.97, "word": " أعلى", "probability": 0.9523111979166666}, {"start": 1246.97, "end": 1247.13, "word": " من", "probability": 0.9970703125}, {"start": 1247.13, "end": 1247.77, "word": " 190", "probability": 0.79052734375}], "temperature": 1.0}, {"id": 58, "seek": 126398, "start": 1248.92, "end": 1263.98, "text": "أذا بأعطيها نص درجة أقل من 190 milligram per deciliter صفر بأعطيها شوية درجة ع الساعة و نص يعني ع 90 minutes ما ساحبلها ع الساعتين يعني ع ال 120 minutes ساحبلها", "tokens": [10721, 15730, 4724, 10721, 3615, 9566, 1829, 11296, 8717, 9381, 11778, 47341, 3660, 5551, 4587, 1211, 9154, 37609, 38298, 680, 979, 388, 1681, 20328, 5172, 2288, 4724, 10721, 3615, 9566, 1829, 11296, 13412, 2407, 10632, 11778, 47341, 3660, 6225, 21136, 995, 27884, 4032, 8717, 9381, 37495, 22653, 6225, 4289, 2077, 19446, 8608, 39319, 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deciliter أو أقل إذا هذا إنسان Normal وسليم", "tokens": [3224, 1211, 7435, 36081, 35186, 10874, 15042, 27884, 22807, 47525, 8315, 8717, 5016, 4117, 1829, 4117, 14407, 18871, 2423, 39184, 21277, 33778, 8717, 5016, 4117, 1829, 4032, 39182, 9957, 8717, 8592, 38688, 2423, 39184, 6187, 1875, 4724, 15042, 7251, 9778, 9381, 6156, 5016, 9381, 16472, 2423, 39184, 4453, 38369, 1610, 304, 5209, 1311, 541, 21402, 260, 719, 9279, 2423, 2407, 11242, 3615, 41950, 21292, 3615, 1829, 45164, 23032, 1211, 3615, 25124, 9778, 9381, 8608, 37983, 3224, 20154, 38298, 680, 979, 388, 1681, 34051, 5551, 4587, 1211, 11933, 15730, 23758, 36145, 3794, 7649, 21277, 46952, 20292, 2304], "avg_logprob": -0.17702964409110472, "compression_ratio": 1.397489539748954, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1662.51, "end": 1662.97, "word": "هلجيت", "probability": 0.835693359375}, {"start": 1662.97, "end": 1663.09, "word": " يا", "probability": 0.94287109375}, {"start": 1663.09, "end": 1664.05, "word": 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81, "seek": 176356, "start": 1734.6, "end": 1763.56, "text": "لكن هذا إنسان Normal لكن لو طلع من 110 لـ 126 milligram per deciliter هذا بيكون pre-diabetic لو طلع السكر 126 أو أعلى هذا بيكون إنسان أكيد ضيابتك وأكيد مريض سكري مابتناش اللخبط بين الـNormal Range الخاصة بفحص الـ OGTT والخاصة بفحص ال fasting blood sugar تمام؟", "tokens": [1211, 19452, 23758, 36145, 3794, 7649, 21277, 44381, 45164, 23032, 1211, 3615, 9154, 20154, 5296, 39184, 2272, 21, 38298, 680, 979, 388, 1681, 23758, 4724, 1829, 30544, 659, 12, 4504, 455, 3532, 45164, 23032, 1211, 3615, 21136, 37983, 2272, 21, 34051, 5551, 3615, 23942, 23758, 4724, 1829, 30544, 36145, 3794, 7649, 5551, 4117, 25708, 48812, 1829, 16758, 2655, 4117, 36725, 4117, 25708, 3714, 16572, 11242, 8608, 4117, 16572, 19446, 3555, 2655, 1863, 33599, 13672, 9778, 3555, 9566, 49374, 2423, 39184, 45, 24440, 33778, 33962, 33546, 3660, 4724, 5172, 5016, 9381, 2423, 39184, 32477, 28178, 16070, 9778, 33546, 3660, 4724, 5172, 5016, 9381, 2423, 22371, 3390, 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تاكلش أكلات لأنه احتمال في المستقبل يصير عندك سكري أما النقطة اللي في النص Embered fasting glucose بيقصد فيها فحص ال fasting blood sugar اللي أخدناه أول مرة", "tokens": [1211, 1211, 28814, 9381, 16758, 3660, 20666, 3794, 4117, 16572, 8978, 9673, 14851, 4587, 36150, 6156, 2655, 3615, 9566, 1829, 3224, 11331, 2304, 10632, 6055, 39648, 26895, 3224, 1975, 1211, 3615, 3555, 12399, 5380, 12399, 19446, 6055, 995, 28820, 8592, 5551, 28820, 9307, 5296, 33456, 3224, 1975, 33753, 2304, 6027, 8978, 9673, 14851, 4587, 36150, 7251, 9381, 13546, 43242, 4117, 8608, 4117, 16572, 5551, 15042, 28239, 47432, 3660, 13672, 1829, 8978, 28239, 9381, 24234, 4073, 22371, 23997, 4724, 1829, 4587, 9381, 3215, 8978, 11296, 6156, 5016, 9381, 2423, 22371, 3390, 5076, 13672, 1829, 5551, 9778, 3215, 8315, 3224, 5551, 12610, 3714, 25720], "avg_logprob": -0.16595874365093638, "compression_ratio": 1.5851528384279476, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 1882.52, "end": 1883.86, "word": "للإصابة", 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This is considered a risk factor for future diabetes. هذا الإنسان اللي جيت عملتله fasting blood sugar وطلع ما بين 110 و126 milligram per deciliter، هذا بقول عنه pre-diabetic، بقول عنه impaired.", "tokens": [18822, 257, 954, 575, 22371, 23997, 2681, 281, 420, 5044, 813, 20154, 293, 1570, 813, 2272, 21, 13, 639, 307, 4888, 257, 3148, 5952, 337, 2027, 13881, 13, 23758, 33688, 1863, 3794, 7649, 13672, 1829, 10874, 36081, 6225, 42213, 2655, 43761, 22371, 3390, 5076, 4032, 9566, 1211, 3615, 19446, 49374, 20154, 4032, 4762, 21, 38298, 680, 979, 388, 1681, 12399, 23758, 4724, 39648, 18871, 3224, 659, 12, 4504, 455, 3532, 12399, 4724, 39648, 18871, 3224, 36762, 13], "avg_logprob": -0.21614583524373862, "compression_ratio": 1.3739495798319328, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 1905.39, "end": 1905.65, "word": "when", "probability": 0.09857177734375}, {"start": 1905.65, "end": 1906.03, "word": " a", "probability": 0.98681640625}, {"start": 1906.03, "end": 1906.51, 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لديها عدد عادل خاص فيه آخر slide الـDiabetes هذا الـNormal Range الخاص في الـOGTT إذا كان شخص يمتلك الـDiabetes وإن أمر الجلوكوز توليرانس تست شهر إن مستوى جلوكوز الدم\nفي ساعات هو أكتر من 200 ملي جرام في ديسليتر لو شخص", "tokens": [28814, 15730, 14111, 28242, 6156, 5016, 9381, 10632, 10874, 15042, 27884, 198, 6027, 20292, 5296, 16254, 11296, 6225, 3215, 3215, 6225, 18513, 1211, 16490, 33546, 8978, 3224, 19753, 34740, 4137, 2423, 39184, 35, 72, 12632, 23758, 2423, 39184, 45, 24440, 33778, 33962, 33546, 8978, 2423, 39184, 45978, 28178, 11933, 15730, 25961, 13412, 9778, 9381, 7251, 2304, 2655, 23275, 2423, 39184, 35, 72, 12632, 4032, 28814, 1863, 5551, 29973, 25724, 1211, 2407, 4117, 2407, 11622, 6055, 12610, 13546, 7649, 3794, 6055, 14851, 13412, 3224, 2288, 36145, 3714, 14851, 2407, 7578, 10874, 1211, 2407, 4117, 2407, 11622, 32748, 2304, 198, 41185, 8608, 45761, 9307, 31439, 5551, 4117, 2655, 2288, 9154, 2331, 3714, 20292, 10874, 2288, 10943, 8978, 11778, 1829, 3794, 20292, 2655, 2288, 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2072.34, "end": 2072.58, "word": " أكوا", "probability": 0.4319661458333333}, {"start": 2072.58, "end": 2073.1, "word": " تعرفوا", "probability": 0.9549153645833334}, {"start": 2073.1, "end": 2073.56, "word": " أنه", "probability": 0.781982421875}, {"start": 2073.56, "end": 2074.24, "word": " سكر", "probability": 0.6221923828125}, {"start": 2074.24, "end": 2074.54, "word": " حمل", "probability": 0.833740234375}, {"start": 2074.54, "end": 2074.92, "word": " بصيب", "probability": 0.7813720703125}, {"start": 2074.92, "end": 2075.38, "word": " الستات", "probability": 0.86181640625}, {"start": 2075.38, "end": 2075.68, "word": " وهي", "probability": 0.688232421875}, {"start": 2075.68, "end": 2076.38, "word": " حوامل", "probability": 0.9853515625}, {"start": 2076.38, "end": 2076.92, "word": " أما", "probability": 0.9560546875}, {"start": 2076.92, "end": 2077.42, "word": " الـNormal", "probability": 0.82275390625}, {"start": 2077.42, "end": 2077.98, "word": " Range", "probability": 0.90869140625}, {"start": 2077.98, "end": 2078.38, "word": " اللي", "probability": 0.85595703125}, {"start": 2078.38, "end": 2079.22, "word": " توحكته", "probability": 0.920654296875}, {"start": 2079.22, "end": 2079.76, "word": " هذا", "probability": 0.69384765625}, {"start": 2079.76, "end": 2080.04, "word": " مش", "probability": 0.98291015625}, {"start": 2080.04, "end": 2081.0, "word": " مطلوب", "probability": 0.974853515625}, {"start": 2081.0, "end": 2082.06, "word": " بالنسبة", "probability": 0.982177734375}, {"start": 2082.06, "end": 2082.6, "word": " لسكر", "probability": 0.8284505208333334}, {"start": 2082.6, "end": 2083.08, "word": " الحمل", "probability": 0.973388671875}, {"start": 2083.08, "end": 2083.72, "word": " مش", "probability": 0.89306640625}, {"start": 2083.72, "end": 2084.7, "word": " مطلوب", "probability": 0.9744873046875}, {"start": 2084.7, "end": 2085.54, "word": " تمام؟", "probability": 0.66845703125}, {"start": 2085.54, "end": 2085.9, "word": " لأن", "probability": 0.87353515625}, {"start": 2085.9, "end": 2086.2, "word": " كل", "probability": 0.67724609375}, {"start": 2086.2, "end": 2086.56, "word": " مختبر", "probability": 0.7237955729166666}, {"start": 2086.56, "end": 2086.84, "word": " له", "probability": 0.6484375}, {"start": 2086.84, "end": 2087.2, "word": " Normal", "probability": 0.7734375}, {"start": 2087.2, "end": 2087.76, "word": " Range", "probability": 0.97216796875}, {"start": 2087.76, "end": 2088.26, "word": " خاص", "probability": 0.98583984375}, {"start": 2088.26, "end": 2088.7, "word": " فيه", "probability": 0.98193359375}, {"start": 2088.7, "end": 2092.4, "word": " تمام؟", "probability": 0.86083984375}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2093.5575625, "duration_after_vad": 2073.259093749997}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/a3GO5ndJhG8_raw.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/a3GO5ndJhG8_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..fc6632bea67d8a12d578ad853fe4356e5afcebff
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/a3GO5ndJhG8_raw.srt
@@ -0,0 +1,1678 @@
+1
+00:00:00,000 --> 00:00:05,140
+بدنا هالجهة نبدأ بفحص الـ OGTT اختصار لـ Oral
+
+2
+00:00:05,140 --> 00:00:11,800
+Glucose Tolerance Test فكرة الفحص بكل بساطة فكرة
+
+3
+00:00:11,800 --> 00:00:17,060
+فحص ال OGTT Oral Glucose من اسمه إنه بيجيك شخص بدي
+
+4
+00:00:17,060 --> 00:00:22,590
+يعمل هذا الفحص بدي يعمل فحص ال OGTTبروح بقى أعطيه
+
+5
+00:00:22,590 --> 00:00:29,250
+قطعة سكر أو سكر مدوب بميه هالجيت بنشوف كيف وبيشربه
+
+6
+00:00:29,250 --> 00:00:33,090
+هالجيت لو جسمه طبيعي الوضع الطبيعي انت أكلت شغل
+
+7
+00:00:33,090 --> 00:00:38,120
+فيها سكر معناه السكر في الدم عندك هيزيدنتيجة زيادة
+
+8
+00:00:38,120 --> 00:00:42,460
+السكر في الدم الإنسولين بتحسس لهذا السكر بيبقى
+
+9
+00:00:42,460 --> 00:00:47,460
+يطلع الإنسولين على الدم وبيبدأ الإنسولين ياخد هذا
+
+10
+00:00:47,460 --> 00:00:52,700
+السكر الموجود في الدم ويبدأش يساوي فيه، يدخله جواه
+
+11
+00:00:52,700 --> 00:00:57,660
+الخلايا عشان دور الإنسولين بديخفض مستوى السكر
+
+12
+00:00:57,660 --> 00:01:03,510
+الموجود في الدمهذا بكل بساطة اللي بيصير هذا أنت
+
+13
+00:01:03,510 --> 00:01:09,710
+إنسان طبيعي استطاع جسمك يتعامل كلمة يتعامل هنا
+
+14
+00:01:09,710 --> 00:01:14,510
+معناها tolerance يتحمل يتعامل لأن جسمك طبيعي
+
+15
+00:01:14,510 --> 00:01:20,650
+استطاع جسمك يتعامل مع جرعة السكر اللي أنا أعطيتك
+
+16
+00:01:20,650 --> 00:01:25,980
+إياهاتمام؟ على سبيل النقط، لو جينا لإنسان عنده
+
+17
+00:01:25,980 --> 00:01:30,500
+مشاكل بالإنسولين وعنده مشاكل بهرمون الإنسولين،
+
+18
+00:01:30,500 --> 00:01:35,320
+أعطيته جرعة سكر، شربها، أكلها، أيا كان، قطعة سكر،
+
+19
+00:01:35,320 --> 00:01:39,810
+سكر في الدم هيزيدعنده مشكلة بالإنسولين هرمون
+
+20
+00:01:39,810 --> 00:01:44,050
+الإنسولين لم يتم إفرازه وبالتالي إيش هيصير في
+
+21
+00:01:44,050 --> 00:01:50,270
+السكر؟ هيظل عالي معناه بنستنتج إن جثم هذا الشخص
+
+22
+00:01:50,270 --> 00:01:54,630
+انتولرانس كلمة intolerance عكس tolerance
+
+23
+00:01:54,630 --> 00:02:00,110
+intolerance معناه لم يتعامل مع جرعة السكر اللي أنا
+
+24
+00:02:00,110 --> 00:02:07,180
+أعطيته إياهإذن بشكل مبسط الإنسان الطبيعي بقدر
+
+25
+00:02:07,180 --> 00:02:11,340
+يتعامل مع جرعة السكر اللي أنا بعطيله إياها
+
+26
+00:02:11,340 --> 00:02:15,900
+Tolerance، يتحمل لإنه عنده إنسلين والإنسلين هيخفض
+
+27
+00:02:15,900 --> 00:02:19,900
+السكر عنده في الدم لكن الإنسان تاني عنده problem،
+
+28
+00:02:19,900 --> 00:02:25,320
+عنده مشاكل في الإنسلين لو أنا أعطيته جرعة سكر جسمه
+
+29
+00:02:25,320 --> 00:02:30,550
+IntoleranceIntolerance معناه لا يستطيع أن يتعامل
+
+30
+00:02:30,550 --> 00:02:34,590
+مع جرعة السكر اللي أنا أعطيته إياه لإنه بكل بساطة
+
+31
+00:02:34,590 --> 00:02:40,390
+الإنسولين فيه مشاكل، تمام؟ هذه فكرة الفحص On a
+
+32
+00:02:40,390 --> 00:02:45,270
+standard oral glucose dose لما أنا أعطيك جرعة من
+
+33
+00:02:45,270 --> 00:02:50,650
+الجلوكوس، طبعا الجلوكوس مش محلول، بتم تناوله عن
+
+34
+00:02:50,650 --> 00:02:55,750
+طريق الفم، تمام؟ بنشرب شرب أو بتاكل جرعة من السكر
+
+35
+00:02:56,390 --> 00:03:01,450
+التجارب عن تجارب الجلوكوز والمتابوليزم لتجارب
+
+36
+00:03:01,450 --> 00:03:06,270
+الجلوكوز يجب أن تكون تولرانة في ملاحظة الانتصاف
+
+37
+00:03:06,270 --> 00:03:11,770
+الطبيعي والعودة هنا حيصير في استجابة لجسمك جسمك
+
+38
+00:03:11,770 --> 00:03:17,230
+هينتص و هيعمل عمليات لهذا الجلوكوز هيطلع الإنسولين
+
+39
+00:03:17,960 --> 00:03:23,640
+هذا الإنسلين بالأول السكر ارتفع الإنسلين هييجي
+
+40
+00:03:23,640 --> 00:03:28,600
+يدخل السكر على الخلايا وبالتالي يـreturn برجع
+
+41
+00:03:28,600 --> 00:03:34,020
+السكر لوضعه الطبيعي تمام؟ إذا جسمك tolerant، اتحمل
+
+42
+00:03:34,020 --> 00:03:39,440
+whereas على سبيل العكس والنقد abnormal and
+
+43
+00:03:39,440 --> 00:03:43,700
+improper glucose metabolism is termed glucose
+
+44
+00:03:43,700 --> 00:03:49,100
+intoleranceالثاني عنده مشكلة في العمليات الخاصة
+
+45
+00:03:49,100 --> 00:03:54,160
+بالجلوكوز مشكلة أنه فيش إنسولين مثلا يخفض مستوى
+
+46
+00:03:54,160 --> 00:03:59,000
+السكر عنده وبالتالي جسمه intolerance مش قادر
+
+47
+00:03:59,000 --> 00:04:03,740
+يتعامل مع جرعة السكر اللي أنا أعطيته إياهاهذه فكرة
+
+48
+00:04:03,740 --> 00:04:08,460
+فحص الـ Oral Glucose Tolerance Test هل جسمك بقدر
+
+49
+00:04:08,460 --> 00:04:13,920
+يتعامل أو لا يستطيع أن يتعامل مع جرعة السكر اللي
+
+50
+00:04:13,920 --> 00:04:18,890
+تم إعطائك إياها، تمام؟this used to diagnose
+
+51
+00:04:18,890 --> 00:04:24,010
+diseases where the glucose metabolism is impaired
+
+52
+00:04:24,010 --> 00:04:29,410
+as in diabetes mellitus فحص ال OGTT مثل فحص ال
+
+53
+00:04:29,410 --> 00:04:34,690
+fasting blood sugar يستخدم بغرض ال diagnosis بغرض
+
+54
+00:04:34,690 --> 00:04:41,660
+التشخيص أقول هل عندكمرض سكري أم سليم، إذا الهدف
+
+55
+00:04:41,660 --> 00:04:45,820
+منه يعني أنا بقدر أعمل فحص الـ OGTT، أي شخص بقدر
+
+56
+00:04:45,820 --> 00:04:49,480
+يعمل فحص الـ OGTT عشان يعرف عنده سكري ولا لا،
+
+57
+00:04:49,480 --> 00:04:54,480
+تمام؟تمام الـ Orange glucose tolerance test هذا
+
+58
+00:04:54,480 --> 00:05:00,340
+الفحص has been widely used as the golden standard
+
+59
+00:05:00,340 --> 00:05:05,160
+for diagnoses of diabetes mellitus in clinically
+
+60
+00:05:05,160 --> 00:05:11,300
+doubtful cases هذا الفحص بشكل منتشر وواسع هو الـ
+
+61
+00:05:11,300 --> 00:05:16,120
+golden standard هو الفحص المثالي الذهبي من أجل
+
+62
+00:05:16,120 --> 00:05:21,460
+التشخيصمن أجل إني أحكي عنك شخص سليم و لا عندك مرض
+
+63
+00:05:21,460 --> 00:05:27,320
+سكري خاصة في الحالات الـDoubtful cases الحالات
+
+64
+00:05:27,320 --> 00:05:31,680
+المشكوك في أمرها اللي لو أنا عملتلها fasting blood
+
+65
+00:05:31,680 --> 00:05:37,120
+sugar بتكونش واضحة كتير عنده سكري و لا لأ فبنطلبله
+
+66
+00:05:37,120 --> 00:05:41,240
+الـ OGTT تمام؟ في الحالات المشكوك في أمرها
+
+67
+00:05:41,240 --> 00:05:44,620
+والحالات العادية اللي بدي أعرف عنده سكر و لا لأ
+
+68
+00:05:44,620 --> 00:05:51,500
+إذا انفحص، لا تتشخيصLately throughout the use of
+
+69
+00:05:51,500 --> 00:05:57,860
+OGTT in primary care has been questioned for
+
+70
+00:05:57,860 --> 00:06:03,140
+several reasons طبعا فحص الـ OGTT فحص بيعمله في
+
+71
+00:06:03,140 --> 00:06:07,720
+الرعاية الأولية وفي المستشفيات لعدة أسباب، بينطلب
+
+72
+00:06:07,720 --> 00:06:13,590
+لعدة أسبابIt has law reproducibility and is very
+
+73
+00:06:13,590 --> 00:06:17,910
+expensive للأسف هذا الفحص مع إنه الفحص الدهبي من
+
+74
+00:06:17,910 --> 00:06:22,390
+أجل التشخيص هل عندك سكري ولا لأ إلا إنه فيه عيوب
+
+75
+00:06:22,390 --> 00:06:27,110
+إنه كتير غالي مش يعني مش كتير كتير غالي إنه لو
+
+76
+00:06:27,110 --> 00:06:31,370
+بدنا نيجي نحكي فحص السكر فحص السكر هذا فحص روتيني
+
+77
+00:06:31,630 --> 00:06:36,110
+يعني يفترض يكون سعره ما يزيدش عن 10 شكل لكن لم
+
+78
+00:06:36,110 --> 00:06:40,450
+أبدأ أحكي لك أعمل فحص السكر بـ20 أو بـ30 زي فحص
+
+79
+00:06:40,450 --> 00:06:44,110
+الـ OGTT، هذه مشكلة إذن المشكلة الأساسية بهذا
+
+80
+00:06:44,110 --> 00:06:49,370
+الفحص إنه كثير غالي ومش دايما بنطلب however for
+
+81
+00:06:49,370 --> 00:06:53,330
+the detection of diabetes in a pregnant woman is
+
+82
+00:06:53,330 --> 00:06:59,390
+still recommended ما زال هذا الفحصاللي بيوصف فيه
+
+83
+00:06:59,390 --> 00:07:04,870
+إنه ينعمل للستات الحوامل اللي بيشكوا إنه عندهم سكر
+
+84
+00:07:04,870 --> 00:07:10,010
+حمل وبيني وبينكم في المستشفيات هذا الفحص بينعملش
+
+85
+00:07:10,010 --> 00:07:14,530
+يعني أنا لو شك عندي سكر ولا لأ بروح المستشفى بعمل
+
+86
+00:07:14,530 --> 00:07:18,990
+فحص ال fasting blood sugar العادي تمام؟ بصوم تمام
+
+87
+00:07:18,990 --> 00:07:24,050
+ساعات و بروح أعملهبس فحص الـ OGTT هنا بينعمل فقط
+
+88
+00:07:24,050 --> 00:07:29,490
+بعيادات الوكالة للستات الحوامل اللي شاكين في عندها
+
+89
+00:07:29,490 --> 00:07:35,380
+سكر حمنهل جيت الشخص اللي بدي يعمل هذا الفحص سواء
+
+90
+00:07:35,380 --> 00:07:39,880
+ست حامل وشاكين عندها سكري أو الشخص العادي بدي يشوف
+
+91
+00:07:39,880 --> 00:07:44,100
+عنده سكر ولا لأ أو طفل انولد شاكين في عنده سكر ولا
+
+92
+00:07:44,100 --> 00:07:48,320
+لأ لازم يكون فيه preparation فيه تحضير للمريض أول
+
+93
+00:07:48,320 --> 00:07:53,380
+إشي ممنوع تعمل أي activity أي نشاط أو جهد don't
+
+94
+00:07:53,380 --> 00:07:58,860
+smoke ممنوع التدخين أو أي exercise يكون نشاطات
+
+95
+00:07:59,450 --> 00:08:05,610
+تعتمد مجهود وصعبة، ممنوع تعملها لمدة 8 ساعات قبل
+
+96
+00:08:05,610 --> 00:08:10,110
+إجراء الفحص أو خلال وانت بتعمل الفحص إذا ممنوع
+
+97
+00:08:10,110 --> 00:08:14,810
+التدخين، ممنوع الـActivity، ممنوع الـExercise لمدة
+
+98
+00:08:14,810 --> 00:08:18,990
+8 ساعات قبل إجراء الفحص يعني قبل 8 ساعات من إجراءك
+
+99
+00:08:18,990 --> 00:08:24,950
+للفحص، بدك تمتنع عن هذه الشغلاتتمام؟ برضه هذا
+
+100
+00:08:24,950 --> 00:08:29,010
+الفحص يعني أنا عارفة إن الأسبوع اللي جاي بيدروح
+
+101
+00:08:29,010 --> 00:08:35,010
+أعمل فحص الـ OGTT لازم أحضر نفسي جابل تلت أيام من
+
+102
+00:08:35,010 --> 00:08:40,050
+عمل الفحص لازم هذه التلت أيام أكل فيها
+
+103
+00:08:40,050 --> 00:08:46,010
+carbohydrate كتير أغذي حالي شوية، تمام؟ Diet، eat
+
+104
+00:08:46,010 --> 00:08:51,850
+a high carbohydrate diet بدك تاكل أكلات مليئة بالـ
+
+105
+00:08:51,850 --> 00:08:58,380
+carbohydrateبداك تاكل تقريبا الوشبه يكون فيها 150
+
+106
+00:08:58,380 --> 00:09:03,580
+جرام يوميا بدي يكون الأكل تبعك فيه Carbohydrate
+
+107
+00:09:03,580 --> 00:09:09,400
+أكتر من 150 جرام يوميا لمدة تلت أيام، إذا قبل ما
+
+108
+00:09:09,400 --> 00:09:14,020
+تعمل الفحص بتلت أيام، بداك تغذي حالك، تاكل وشبهات
+
+109
+00:09:14,020 --> 00:09:19,560
+مليئة بالـ Carbohydratethen وبعد هيك بعد التلت
+
+110
+00:09:19,560 --> 00:09:23,600
+أيام اليوم الرابع بدك تعمل فحص بعد هيك بدك تبدأ
+
+111
+00:09:23,600 --> 00:09:29,740
+تصوم then fast لازم قبل ما أجري هذا الفحص أصوم من
+
+112
+00:09:29,740 --> 00:09:36,100
+عشرة لاتناشر ساعة10، 11، 12، في ناس بتصوم تمانية
+
+113
+00:09:36,100 --> 00:09:43,540
+برضه صح انصوم 10 لـ 12 ساعة قبل إجراء الفحص وممنوع
+
+114
+00:09:43,540 --> 00:09:47,920
+في فترة الصوم تشرب كافي أو تشرب .. الأشخاص طبعا
+
+115
+00:09:47,920 --> 00:09:53,140
+بيشربوا كحول لمدة 8 ساعات قبل إجراء الفحص فقط
+
+116
+00:09:53,140 --> 00:09:58,920
+الشغل المسموح فيها أشربهاوانا صايمة الميّه بتصومي
+
+117
+00:09:58,920 --> 00:10:02,000
+عن كل إشي إلا الميّه عادى الميّه مسموح إليك في هذا
+
+118
+00:10:02,000 --> 00:10:06,980
+الفحص تشربيها تمام؟ أي drugs أي أدوية أي
+
+119
+00:10:06,980 --> 00:10:12,400
+medication أنت بتاخدها؟لازم تخبر أخصائي التحليل
+
+120
+00:10:12,400 --> 00:10:18,180
+إنك بتاخد علاج كذا كذا لأنه بخاف هذا العلاج يأثر
+
+121
+00:10:18,180 --> 00:10:23,420
+على نتيجة الفحص Drug medicines inform the person
+
+122
+00:10:23,420 --> 00:10:27,240
+performing the test to omit any medication listed
+
+123
+00:10:27,240 --> 00:10:31,900
+يقولنا إيش بياخد أدوية as undertaking this drug
+
+124
+00:10:31,900 --> 00:10:35,540
+the test result maybe differ ممكن وإنت ممكن هذه
+
+125
+00:10:35,540 --> 00:10:39,810
+الأدوية تأثر على نتيجة الفحصالـ Contraceptive حبوب
+
+126
+00:10:39,810 --> 00:10:44,850
+منع الحمل to be stopped لازم نوقفها one cycle
+
+127
+00:10:44,850 --> 00:10:50,250
+before the performance of the OGTT إذن حبوب منع
+
+128
+00:10:50,250 --> 00:10:54,630
+الحمل برضه بتأثر على هذا الفحص وأدوية أخرى بتأثر
+
+129
+00:10:54,630 --> 00:10:59,210
+عشان هيك هنا ضربوا مثال عشان هيك أي أدوية لازم
+
+130
+00:10:59,210 --> 00:11:02,610
+نحكي فيها ونحكي إنه إحنا بناخد هذا الدواء جاب ال
+
+131
+00:11:02,610 --> 00:11:07,160
+manager الفحص ال test must be performed atdaytime
+
+132
+00:11:07,160 --> 00:11:14,540
+يعني ممكن بأي وقت في اليوم تعمل الفحص يفضل يفضل at
+
+133
+00:11:14,540 --> 00:11:18,760
+the morning في الصباح الباكر تقريبا معاك من الساعة
+
+134
+00:11:18,760 --> 00:11:23,400
+سبعة صباحا لتسعة صباحا في هذا الوقت أفضل وقت من
+
+135
+00:11:23,400 --> 00:11:25,880
+أجل إجراء فحص ال OGTT
+
+136
+00:11:28,620 --> 00:11:32,800
+هل جيتش بحكي ليه؟ test usually takes الفحص بياخد
+
+137
+00:11:32,800 --> 00:11:37,840
+تلات ساعات، تلاتة hours but can last as long as
+
+138
+00:11:37,840 --> 00:11:42,840
+the man كان ياخد ست ساعات معاهم، تمام؟ drink water
+
+139
+00:11:42,840 --> 00:11:47,020
+frequently during the test عادي، ممكن أثناء و أنت
+
+140
+00:11:47,020 --> 00:11:50,660
+بتعمل الفحص خلال التلات ساعات تعود الفحص ممكن تشرب
+
+141
+00:11:50,660 --> 00:11:55,950
+ميه فقط الميه اللي مسموح فيها تشربهاالصحابة الأولى
+
+142
+00:11:55,950 --> 00:12:01,050
+والصحابة الأولى الصحابة الهوائية تتجمد بين الساعة
+
+143
+00:12:01,050 --> 00:12:08,230
+السابعة والتسعة بعد أنك فطرت 12 ساعةهل جيت الكلام
+
+144
+00:12:08,230 --> 00:12:13,490
+اللي موجود بالـ slide نشوف تحت operator gives a
+
+145
+00:12:13,490 --> 00:12:18,070
+test load of glucose usually من 75 لـ 100 جرام من
+
+146
+00:12:18,070 --> 00:12:22,610
+الـ dextrose اللي هو الجلوكوز اندوب بـ 300 أم
+
+147
+00:12:22,610 --> 00:12:28,870
+الواتر أو اندوب باللمون drink the entire solution
+
+148
+00:12:28,870 --> 00:12:34,340
+in 5 minutesهل جيت احنا كلام نسليدات يعني احنا
+
+149
+00:12:34,340 --> 00:12:37,140
+بنشوف ايش بيصير عندنا في غزة في الواقع يعني كيف
+
+150
+00:12:37,140 --> 00:12:41,500
+بنعمل الفحص الفحص عندنا للأمانة بيستغرق two hour
+
+151
+00:12:41,500 --> 00:12:46,380
+فقط ساعتين مش تلاتة ولا ستة تمام بيستغرق ساعتين
+
+152
+00:12:46,380 --> 00:12:51,640
+عشان هيك بيسموه الـ two hour الـ two hour oral
+
+153
+00:12:51,640 --> 00:12:56,900
+glucose tolerance test two hour OGTT هيك اسم الفحص
+
+154
+00:12:56,900 --> 00:13:02,070
+لأنه بيستغرق ساعتينتمام؟ إيش بنحكي للست الحامل؟
+
+155
+00:13:02,070 --> 00:13:07,590
+المهم تيجي لطايمة من 10 إلى 12 ساعة أن التحضيرات
+
+156
+00:13:07,590 --> 00:13:12,570
+الأخرى تاكل carbohydrate وما تعملش exercise، هذه
+
+157
+00:13:12,570 --> 00:13:16,110
+كلها شغلات .. هذه ال standard، شغلات مثلية، بس
+
+158
+00:13:16,110 --> 00:13:19,580
+للأمانةما بتتطبقش عندنا، يعني هذا اللي بيصير عندنا
+
+159
+00:13:19,580 --> 00:13:24,540
+ست حامل، بقولها المرة الجاية بدنا نعملك OGTT، هذا
+
+160
+00:13:24,540 --> 00:13:28,260
+الفحص، تيجيلي أهم إشي صايمة من عشر إلى أتناشر
+
+161
+00:13:28,260 --> 00:13:31,480
+ساعة، تيجي صايمة من عشر إلى أتناشر ساعة، تيجي
+
+162
+00:13:31,480 --> 00:13:37,360
+للمختبر، تمام؟ تجعدأول ما تيجي يفترض أحكي لها معك
+
+163
+00:13:37,360 --> 00:13:41,380
+من الساعة سبعة لساعة تسعة في هذا الواجت في الصباح
+
+164
+00:13:41,380 --> 00:13:45,780
+الباكر أفضل واجت لصحب العينة تجيني وهي صايمة
+
+165
+00:13:45,780 --> 00:13:51,600
+بصحبلها عينة الدم وهذه العينة بشتغللها fasting
+
+166
+00:13:51,600 --> 00:13:57,260
+blood sugar بشتغللها فحص السكر fasting وهي صايمة
+
+167
+00:13:57,260 --> 00:14:01,840
+لأن هي أصلا صايمةإذن أول ما تيجي الست الحامل على
+
+168
+00:14:01,840 --> 00:14:05,360
+المختبر كاينة صايمة عشر ساعات أو تمانية أو اتناش
+
+169
+00:14:05,360 --> 00:14:12,020
+بسحب منها عينةوهذه العينة بشتغللها فحص السكر وهذا
+
+170
+00:14:12,020 --> 00:14:17,320
+الفحص بنسميه fasting blood sugar وبسجل النتيجة
+
+171
+00:14:17,320 --> 00:14:22,460
+بنفس الوقت بقلب منها تروح تجيبلي عينة يورين عشان
+
+172
+00:14:22,460 --> 00:14:27,140
+بالـ strip أشوف في اليورين فيه ثقر ولا لا تمام،
+
+173
+00:14:27,140 --> 00:14:31,860
+هاي نخلص، سحبنا منها عينة دم وأخدنا منها عينة
+
+174
+00:14:31,860 --> 00:14:37,610
+يورينهلجيت بقى أجعد الست على كرسي و بروح أجبلها
+
+175
+00:14:37,610 --> 00:14:44,990
+جرعة سكر هذا السكر إما بدأ مدوب بميه أو مدوب بلمون
+
+176
+00:14:44,990 --> 00:14:50,650
+و بخليها تشربه زي المحلول تشربه عن طريق الفن تمام؟
+
+177
+00:14:52,160 --> 00:14:57,860
+هذا السكر بيحكيلك كميته من خمسة وسبعين لمائة جرام
+
+178
+00:14:57,860 --> 00:15:02,500
+بتوزنيها وزنة بتجيب السكر أو ديكستروز بيجي جاهز
+
+179
+00:15:02,500 --> 00:15:07,500
+طبعا من الشركات من خمسة وسبعين لمائة جرام بتوزني
+
+180
+00:15:07,500 --> 00:15:12,120
+وزنة و بتدوبيهم في تلاتمية قمقة الميه أو في لمون
+
+181
+00:15:12,120 --> 00:15:17,140
+اللي هي ميه بنكهة اللمون عشان تقدر تشربه وبخليها
+
+182
+00:15:17,140 --> 00:15:23,540
+تشربه تمام؟ وبخليها جاعدةلساعتين، بتظل جاعدة
+
+183
+00:15:23,540 --> 00:15:28,060
+لساعتين يعني بعد ما شربت محلول السكر بتظلها جاعدة
+
+184
+00:15:28,060 --> 00:15:35,220
+لساعتين بعد ساعتين بصحب منها عينة وبحلل هذه العينة
+
+185
+00:15:35,220 --> 00:15:39,840
+وبناءً، وبحللها يعني بعمل تحليل السكر عليها وبناءً
+
+186
+00:15:39,840 --> 00:15:45,440
+على نتيجة هذه العينة بقول هذه الست عندها سكر ولا
+
+187
+00:15:45,440 --> 00:15:51,330
+سليمة، تمام؟هذه قليلة الفحص عندنا احنا، هذه قليلة
+
+188
+00:15:51,330 --> 00:15:57,190
+الفحص عندنا احنا لكن شوفوا كلام الـ slides وشوفوا
+
+189
+00:15:57,190 --> 00:16:01,030
+الفحص المثالي اللي عن جد يفترض ينعمل هيك تيجي
+
+190
+00:16:01,030 --> 00:16:05,890
+السيدة صايمة بسحبلها عينة blood و هي صايمة و
+
+191
+00:16:05,890 --> 00:16:09,790
+بعملها فحص ال fasting blood sugar و بطلب منها عينة
+
+192
+00:16:09,790 --> 00:16:15,000
+يورين و بشوف فيها سكر ولا لأ و بجعدها، تمام؟بعد
+
+193
+00:16:15,000 --> 00:16:21,740
+هيك بروح باجبلها المحلول السكري بشربها إياه بعد ما
+
+194
+00:16:21,740 --> 00:16:28,140
+تشرب المحلول السكري بنص ساعة بسحب منها عينة الدم
+
+195
+00:16:28,140 --> 00:16:33,660
+وبشتغللها فحص السكروبعدين بقول هروح ارتاحى بعد
+
+196
+00:16:33,660 --> 00:16:38,700
+كمان نص ساعة بروح كمان أسحب منها عينة و بشتغللها
+
+197
+00:16:38,700 --> 00:16:44,060
+فحص السكر وبعد كمان نص ساعة برضه بسحب منها عينة ال
+
+198
+00:16:44,060 --> 00:16:48,520
+blood و بشتغللها كمان فحص السكر زى ما انتوا شايفين
+
+199
+00:16:48,520 --> 00:16:53,080
+ل blood sample أول واحدة بسحبلها و هي صايمة أول ما
+
+200
+00:16:53,080 --> 00:16:57,700
+توصل مختبر ال fasting blood sugar sample بعطيها
+
+201
+00:16:57,700 --> 00:17:03,930
+جرعة السكروبعد نص ساعة من تناول جرعة السكر بسحبلها
+
+202
+00:17:03,930 --> 00:17:08,390
+عينة تلاتين minutes after oral glucose load يعني
+
+203
+00:17:08,390 --> 00:17:12,750
+بعد ما تاخد جرعة السكر بعد نص ساعة بسحبلها عينة
+
+204
+00:17:12,750 --> 00:17:17,970
+بعدين لما تصير ستين دقيقة بسحبلها عينة يعني كمان
+
+205
+00:17:17,970 --> 00:17:22,770
+نص ساعة تانينولمّا تصير ساعة ونص برضه بسحب لها
+
+206
+00:17:22,770 --> 00:17:27,970
+عينة تالتة ولمّا تصير ساعتين عند الـ120 minute
+
+207
+00:17:27,970 --> 00:17:33,090
+برضه ب .. برضه ب .. برضه ب .. أسحب منها كمان عينة
+
+208
+00:17:33,090 --> 00:17:39,170
+متخيلين عشان أعمل فحص الـ OGTT أكم عينة لازم أحسب
+
+209
+00:17:39,170 --> 00:17:43,290
+.. أسحب من هذه الستيعني تقريبًا خمس عينات، يعني
+
+210
+00:17:43,290 --> 00:17:47,550
+أنا لو بدي أجي أعمل هذا الفحص عند الناس أو هنا في
+
+211
+00:17:47,550 --> 00:17:51,530
+غزة، بدربوني، إيش تسحب مني خمس عينات blood؟ كتير
+
+212
+00:17:51,530 --> 00:17:56,570
+متعب الفحص، فعشان هيك إحنا عندنا اقتصر المسافة
+
+213
+00:17:56,570 --> 00:18:01,130
+Fasting blood sugar أول ما تصل، بحصولها السكر و هي
+
+214
+00:18:01,130 --> 00:18:06,680
+صايمة، بدوها جرعة السكريبعدين بيعطوها جرعة السكر
+
+215
+00:18:06,680 --> 00:18:11,920
+بيخلوها ترتاح وبعد ما ترتاح ساعتين بيصحبوا عينة
+
+216
+00:18:11,920 --> 00:18:17,170
+تانية يعني فعليا بس عينتين دمعينة و هي صايمة و
+
+217
+00:18:17,170 --> 00:18:24,190
+عينة بعد ساعتين من تناول جرعة السكر تمام؟ الـ
+
+218
+00:18:24,190 --> 00:18:28,550
+urine sample بيقول لك كل عينة دم بيسحبولها إياها
+
+219
+00:18:28,550 --> 00:18:32,690
+لازم تروح تجيب معها عينة urine يشتغلوها first
+
+220
+00:18:32,690 --> 00:18:36,950
+fasting urine and hourly collected urine sample
+
+221
+00:18:36,950 --> 00:18:40,290
+يعني أول إشي لما تكون صايمة بيطلبوا عينة urine و
+
+222
+00:18:40,290 --> 00:18:43,880
+بعد هيك كل ساعة بدهم عينة urineانتوا متخيلين الفحص
+
+223
+00:18:43,880 --> 00:18:48,160
+كان بيستغرق 6 ساعات و 3 ساعات كل نص ساعة بيسحب
+
+224
+00:18:48,160 --> 00:18:51,480
+عينا من الست كل نص ساعة بيسحب عينا من الست وهذا
+
+225
+00:18:51,480 --> 00:18:55,840
+كتير مجهد و .. و .. و بتعب نفسيت المريض، تمام؟
+
+226
+00:18:57,830 --> 00:19:01,810
+هلجيت بس بدي أحكي عن الـ Normal Range اللي خاص
+
+227
+00:19:01,810 --> 00:19:05,130
+بالـ Two Hour Oral Glucose Tolerance Test عندنا
+
+228
+00:19:05,130 --> 00:19:09,630
+بغزا لو بعد ساعتين يعني بعد ما أعطيتك جرعة السكر
+
+229
+00:19:09,630 --> 00:19:14,170
+تمام بعد ساعتين لما أجي أعملك فحص السكر إذا طلع
+
+230
+00:19:14,170 --> 00:19:18,730
+سكرك 110 milligram per deciliter أو أقل هذا إنسان
+
+231
+00:19:18,730 --> 00:19:24,040
+Normalبين 140 لـ 200 ميلي جرام per deciliter هذا
+
+232
+00:19:24,040 --> 00:19:28,000
+إنسان pre-diabetic يعني عنده risk factor للمستقبل
+
+233
+00:19:28,000 --> 00:19:33,940
+إنه ينصب بمرض السكري لو طلع سكرا 200 ميلي جرام per
+
+234
+00:19:33,940 --> 00:19:38,260
+deciliter أو أعلى من 200 هذا بيكون مؤكد diabetic
+
+235
+00:19:38,260 --> 00:19:43,170
+إنسان مريض سكرياللي أمامنا جدول أكيد مش حفظ بس
+
+236
+00:19:43,170 --> 00:19:48,450
+بدنا نفهم و نفهم Calculation بظهرلك كل عالم كيف
+
+237
+00:19:48,450 --> 00:19:53,410
+كان بيشتغل فحص الـ OGTT لأنه كل عالم استخدم طريقة
+
+238
+00:19:53,410 --> 00:19:59,190
+مختلفة لشغل الـ OGTT وبرضه تحليل نتيجة الـ OGTT
+
+239
+00:19:59,190 --> 00:20:05,150
+برضه مختلفة من عالم لعالم، تمام؟هلجيت عندنا و الـ
+
+240
+00:20:05,150 --> 00:20:08,690
+Carson criteria العالم و الـ Carson كيف اشتغل الـ
+
+241
+00:20:08,690 --> 00:20:13,210
+OGTT و كيف حلل النتيجة جالب تيجي السيد صايمة
+
+242
+00:20:13,210 --> 00:20:17,170
+fasting تمام و بيسحب منها عينة و بيشتغللها فحص
+
+243
+00:20:17,170 --> 00:20:23,030
+السكر fasting blood sugarلو طلع سكرها 130 أو أعلى
+
+244
+00:20:23,030 --> 00:20:28,130
+من 130 بأعطيها 1 point بأعطيها درجة طيب لو سكرها
+
+245
+00:20:28,130 --> 00:20:32,850
+كان أقل من 130 بيعطيها صفر يعني مافيش إلها ولا
+
+246
+00:20:32,850 --> 00:20:37,690
+درجة بعدين بيعطيها المحلول السكري بعد نص ساعة ما
+
+247
+00:20:37,690 --> 00:20:41,630
+بيسحبلها دم هي حاطة شحتة يعني ما بيسحبلها دم بعد
+
+248
+00:20:41,630 --> 00:20:46,690
+ساعة من إعطاءها محلول السكر بيسحبلها دم لو طلع
+
+249
+00:20:46,690 --> 00:20:52,440
+أعلى من 190أذا بأعطيها نص درجة أقل من 190
+
+250
+00:20:52,440 --> 00:20:56,280
+milligram per deciliter صفر بأعطيها شوية درجة ع
+
+251
+00:20:56,280 --> 00:21:00,500
+الساعة و نص يعني ع 90 minutes ما ساحبلها ع
+
+252
+00:21:00,500 --> 00:21:05,930
+الساعتين يعني ع ال 120 minutes ساحبلهاوفحصها لو
+
+253
+00:21:05,930 --> 00:21:10,810
+طلع دمها أكتر من سكر الدم أكتر من 140 milligram
+
+254
+00:21:10,810 --> 00:21:14,970
+per deciliter بعطيها نص point، نص درجة أقل من 140
+
+255
+00:21:14,970 --> 00:21:18,930
+ما بيعطيها ولا درجة سفر ع الساعتين ونص برضه
+
+256
+00:21:18,930 --> 00:21:23,130
+بيسحبلها عينة دم أخرى طلعت أكتر من 130 milligram
+
+257
+00:21:23,130 --> 00:21:27,450
+per deciliter بعطيها point أقل من 130 ما بيعطيها
+
+258
+00:21:27,450 --> 00:21:31,390
+ولا point سفرالـ Result في الآخر بيقولّك بيجمع ال
+
+259
+00:21:31,390 --> 00:21:35,010
+points بيجمع النقاط لو طلعت من اتنين لتلاتة point
+
+260
+00:21:35,010 --> 00:21:39,350
+بتكون هذه ال 6 diabetic لو طلع مجموع نقاطها من نص
+
+261
+00:21:39,350 --> 00:21:42,770
+لواحد و نص point بتكون Suspected يعني Pre-diabetic
+
+262
+00:21:42,770 --> 00:21:48,050
+لو طلعوا مجموع النقاط Zero معناها Non-diabetic هنا
+
+263
+00:21:48,050 --> 00:21:53,370
+لو جمعناهي نقطة، نقطين و نص ذائب نص، نقطة يعني هاي
+
+264
+00:21:53,370 --> 00:21:57,850
+تلاتة point تلاتة point صنفهم ضيابتك أما إيجي عالم
+
+265
+00:21:57,850 --> 00:22:02,710
+آخر Vajankund criteria الست بتكون okay صايمة لكن
+
+266
+00:22:02,710 --> 00:22:06,830
+ما بيسحبلها عينة و هي صايمة وبعطيها جرعة السكر ما
+
+267
+00:22:06,830 --> 00:22:10,010
+بيسحبلها عينة على التلاتين minute بيسحبلها عينة
+
+268
+00:22:10,010 --> 00:22:13,600
+على الساعةعالـ 60 minutes يعني بعد ما يعطيها جرعة
+
+269
+00:22:13,600 --> 00:22:18,780
+السكر بساعة لو طلعت أعلى من 190 بعطيها plus 1 أقل
+
+270
+00:22:18,780 --> 00:22:23,160
+من 190 بعطيها صفر وعالساعة و نص يعني عالـ 90
+
+271
+00:22:23,160 --> 00:22:28,320
+minutes برضه بحسبلها و بسحبلها عينة و بحسب نسبة
+
+272
+00:22:28,320 --> 00:22:33,740
+السكر فيها أعلى من 165 بعطيها plus 1 أقل من 165
+
+273
+00:22:33,740 --> 00:22:39,140
+بعطيها صفر عالساعتين يعني عالـ 120 minutes برضه
+
+274
+00:22:39,140 --> 00:22:44,360
+بسحبلها كمان عينةطلع السكر أعلى من 140 بيعطيها
+
+275
+00:22:44,360 --> 00:22:49,460
+plus 1 أجل من 140 بيعطيها صفر point في الآخر بيجمع
+
+276
+00:22:49,460 --> 00:22:54,920
+النقاط لو طلعت تلاتة مجموعهم إذا هي ضيبتك من 1 ل 2
+
+277
+00:22:54,920 --> 00:22:59,980
+suspect إذا مافيش كل صفر إذا ما ضيبتك هنا تلاتة
+
+278
+00:22:59,980 --> 00:23:04,620
+مجموعهم plus 1 plus 1 plus 1 إذا هي ضيبتك آخر عالم
+
+279
+00:23:04,620 --> 00:23:09,720
+revised some nationهذا العالم إيش قال تي جستت
+
+280
+00:23:09,720 --> 00:23:13,240
+بيعمللها الفحص و هي صايمة F معناها fasting blood
+
+281
+00:23:13,240 --> 00:23:17,280
+sugar تمام و هي صايمة بيعمللها الفحص و بيسجل ال
+
+282
+00:23:17,280 --> 00:23:22,880
+result تبعت السكروبروح ع الساعة بعدين بيعطيها جرعة
+
+283
+00:23:22,880 --> 00:23:26,600
+السكر بعد ساعة من إعطاءها محلول السكري يعني ع
+
+284
+00:23:26,600 --> 00:23:31,560
+الـ60 دقيقة بيسحبلها عينة و بعد ساعة و نص يعني ع
+
+285
+00:23:31,560 --> 00:23:36,180
+الـ90 دقيقة برضه بيسحبلها عينة وع الـ120 دقيقة
+
+286
+00:23:36,180 --> 00:23:40,840
+يعني بعد ساعتين برضه بيسحبلها عينةوفي كل مرة
+
+287
+00:23:40,840 --> 00:23:45,080
+بيفحصلها مستوى السكر نسبة السكر في الدم هالجيت ال
+
+288
+00:23:45,080 --> 00:23:50,560
+results النتيجة يعني وهي صايمة وع الساعة وع الساعة
+
+289
+00:23:50,560 --> 00:23:55,400
+ونصف وع الساعتين ال results تبعت السكر نسب السكر
+
+290
+00:23:55,400 --> 00:23:59,940
+بيروحوا هو جمعهم عامل لهم summation مثلا طلع السكر
+
+291
+00:23:59,940 --> 00:24:05,520
+عندي 120 المرة التانية 105، 200، 300، بجمع هذه
+
+292
+00:24:05,520 --> 00:24:12,850
+الأرقامتمام؟ ولو طلع مجموع السكر فيه هاديفي الـ
+
+293
+00:24:12,850 --> 00:24:15,850
+Fasting و الـ 60 Minutes و الـ 90 Minutes و الـ
+
+294
+00:24:15,850 --> 00:24:19,450
+120 Minutes لو طلع مجموع السكر أعلى من 600
+
+295
+00:24:19,450 --> 00:24:22,770
+Milligrams per deciliter إذا الست بتكون Diabetic
+
+296
+00:24:22,770 --> 00:24:27,110
+لو الـ Summation لنسب السكر كانت أجل من 600
+
+297
+00:24:27,110 --> 00:24:30,290
+Milligrams per deciliter إذا هي Non-Diabetic
+
+298
+00:24:30,290 --> 00:24:35,150
+نستنتج من هنا طبعا لا بدنا نحفظ ولا بدنا نعرف إشي
+
+299
+00:24:35,150 --> 00:24:39,890
+بس أهم إشي نفهم إن كل عالم كانت طريقة شغله للفحص
+
+300
+00:24:39,890 --> 00:24:44,170
+مختلفةوالـ Interpretation برضه للنتائج وتحليله
+
+301
+00:24:44,170 --> 00:24:51,150
+للنتائج برضه كانت مختلفة، واتحط «إنسلين ليفنز
+
+302
+00:24:51,150 --> 00:24:54,230
+اكسبلين دا جيلوكوس توليرانس كيرف» هذا ال curve
+
+303
+00:24:54,230 --> 00:24:57,890
+already احنا يا جماعة حكيناه قبل، هذا ال curve
+
+304
+00:24:57,890 --> 00:25:02,230
+اسمه tolerance curve لإنسان سليم اللي جسمه بيقدر
+
+305
+00:25:02,230 --> 00:25:06,470
+يتعامل مع جرعة السكر اللي بياخدهااللون البنفسجي،
+
+306
+00:25:06,470 --> 00:25:10,530
+الـ Move هو خط الإنسولين واللون الأخضر هو خط
+
+307
+00:25:10,530 --> 00:25:16,050
+الجلوكوز هلجيت لو جينا على الـ Y-axis عند 90 ميلي
+
+308
+00:25:16,050 --> 00:25:19,850
+جرام per deciliter هذه نسبة السكر عند الإنسان
+
+309
+00:25:19,850 --> 00:25:23,530
+الطبيعي، احنا حكينا من 70 ل110، هو طالع عنده 90
+
+310
+00:25:23,530 --> 00:25:28,310
+هلجيت لو روحت أنا أعطيته جرعة سكر، إيش بتتخيلوا
+
+311
+00:25:28,310 --> 00:25:33,190
+المنحنى الأخضر هيصير، هيرتفع؟ يعني سكره هيزيد في
+
+312
+00:25:33,190 --> 00:25:38,170
+الدم، تمام، هيزادفي المقابل، لما السكر يزيد في
+
+313
+00:25:38,170 --> 00:25:42,650
+الدم، كمان الإنسولين بدي يزيد، هاي الخط البنفسجي
+
+314
+00:25:42,650 --> 00:25:46,310
+زاد، هاي الأثنين زادوا مع بعض، ليش الإنسولين زاد؟
+
+315
+00:25:46,310 --> 00:25:51,030
+عشان بدي يبدأ يخفض من مستوى السكر، عند حد معين،
+
+316
+00:25:51,030 --> 00:25:55,030
+شوفوا الـcurve الأخضر، إيش صار فيه؟ الخط الأخضر
+
+317
+00:25:55,030 --> 00:26:00,210
+نزل، معناه السكر بدأ ينزل، ليش؟ لأن الإنسولين خفضه
+
+318
+00:26:00,700 --> 00:26:05,500
+لما السكر بدأ يجل و تمام برضه الإنسولين بدي يبدأ
+
+319
+00:26:05,500 --> 00:26:10,980
+يجل عشان فيش إشي دلّه مرتفع إذا الإنسولين خفض
+
+320
+00:26:10,980 --> 00:26:15,560
+السكر هي الـ curve الأخضر بدأ ينزل و لما نزل السكر
+
+321
+00:26:15,560 --> 00:26:21,280
+برضه بدأ الإنسولين خلاص بدأ الإنسولين ينخفض و بطل
+
+322
+00:26:21,280 --> 00:26:27,280
+ينفرز لأن السكر انخفضتمام؟ هذا اللي بدنا نفهمه من
+
+323
+00:26:27,280 --> 00:26:32,520
+الرسمة لو قرأنا المربعات اللي لونهم Orange Rising
+
+324
+00:26:32,520 --> 00:26:36,260
+blood glucose stimulate insulin production ارتفاع
+
+325
+00:26:36,260 --> 00:26:40,920
+مستوى السكر أدى إلى زيادة مستوى الإنسلين في الدم
+
+326
+00:26:40,920 --> 00:26:46,500
+High level من الإنسلين لما زاد الإنسلينسبب drop in
+
+327
+00:26:46,500 --> 00:26:51,320
+blood glucose سبب انخفاض في مستوى السكر as a
+
+328
+00:26:51,320 --> 00:26:57,300
+glucose level لما مستوى السكر انخفض there is less
+
+329
+00:26:57,300 --> 00:27:01,360
+stimulation for insulin production بطل في عنا حافظ
+
+330
+00:27:01,360 --> 00:27:06,060
+للانسولين يظل عالي وموجود في الدم and insulin drop
+
+331
+00:27:06,060 --> 00:27:10,860
+برضه الانسولين انخفضوالـ Insulin level returned to
+
+332
+00:27:10,860 --> 00:27:15,100
+normal بعد هيك خلاص رجع الإنسولين لتركيزه الطبيعي
+
+333
+00:27:15,100 --> 00:27:21,120
+الجليكوز بدأ يرتفع بشكل تدريجي لحد ما يصل لوضعه
+
+334
+00:27:21,120 --> 00:27:25,040
+الطبيعي اللي بدنا نفهمه أن الأتنين بيرتفعوا مع بعض
+
+335
+00:27:25,040 --> 00:27:30,480
+والأتنين بنخفضوا مع بعض، تمام؟لأنه لو ارتفع السكر،
+
+336
+00:27:30,480 --> 00:27:34,960
+هيزيد الإنسولين عشان يخفض السكر، ولو جل السكر
+
+337
+00:27:34,960 --> 00:27:39,580
+وانخفض خلاص الإنسولين خلص دوره، برضه هينخفض ويرجع
+
+338
+00:27:39,580 --> 00:27:45,250
+لوضعه الطبيعيهلجيت يا جماعة؟ بدنا نحكيكوا عن الـ
+
+339
+00:27:45,250 --> 00:27:49,350
+Normal Range نحكي و بعدين نشوف الـ Slides بما يخص
+
+340
+00:27:49,350 --> 00:27:53,670
+فحص ان الـ Two Hour Oral Glucose Tolerance Test
+
+341
+00:27:53,670 --> 00:27:59,270
+الوضع الطبيعي لو طلع الشخص سكره 110 milligram per
+
+342
+00:27:59,270 --> 00:28:04,870
+deciliter أو أقل إذا هذا إنسان Normal وسليمطيب لو
+
+343
+00:28:04,870 --> 00:28:10,690
+طلع السكر عنده من 140 ل 200 في هذا الـ range من
+
+344
+00:28:10,690 --> 00:28:15,690
+140 ل 200 milligram per deciliter هذا pre-diabetic
+
+345
+00:28:15,690 --> 00:28:19,190
+الـ pre-diabetic يعني عنده risk factor في المستقبل
+
+346
+00:28:19,190 --> 00:28:25,720
+للإصابة بالسكرلو طلع سكره 200 أو أعلى من 200 فهذا
+
+347
+00:28:25,720 --> 00:28:31,380
+أكيد Diabetic هذه الـ Normal Range الصحيحة والخاصة
+
+348
+00:28:31,380 --> 00:28:37,250
+بفحص الـ Oral Glucose Tolerance Test تمام؟أما
+
+349
+00:28:37,250 --> 00:28:42,570
+بالنسبة للـ Normal Range الخاصة بأول فحص أخدناه
+
+350
+00:28:42,570 --> 00:28:46,770
+الـ Fasting Blood Sugar تمام؟ هذا الفحص اللي احنا
+
+351
+00:28:46,770 --> 00:28:53,030
+كلنا بنعمله الوضع الطبيعي من 70 ل110 milligram per
+
+352
+00:28:53,030 --> 00:28:59,720
+deciliterلكن هذا إنسان Normal لكن لو طلع من 110 لـ
+
+353
+00:28:59,720 --> 00:29:04,500
+126 milligram per deciliter هذا بيكون pre-diabetic
+
+354
+00:29:04,500 --> 00:29:11,440
+لو طلع السكر 126 أو أعلى هذا بيكون إنسان أكيد
+
+355
+00:29:11,440 --> 00:29:15,120
+ضيابتك وأكيد مريض سكري مابتناش اللخبط بين
+
+356
+00:29:15,120 --> 00:29:20,560
+الـNormal Range الخاصة بفحص الـ OGTT والخاصة بفحص
+
+357
+00:29:20,560 --> 00:29:26,690
+ال fasting blood sugar تمام؟نشوف أول نقطة باللون
+
+358
+00:29:26,690 --> 00:29:31,170
+الأحمر Normal Response هنا جزده الـ Normal Range
+
+359
+00:29:31,170 --> 00:29:36,110
+الخاصة بالـ Oral Glucose Tolerance Test a person
+
+360
+00:29:36,110 --> 00:29:39,690
+is said to have a normal response when the two
+
+361
+00:29:39,690 --> 00:29:43,650
+-hour glucose level is less than or equal to 110
+
+362
+00:29:43,650 --> 00:29:48,110
+milligram per deciliter، هذا الوضع الطبيعيللإنسان
+
+363
+00:29:48,110 --> 00:29:52,510
+الطبيعي لو عملتله فحص الـ OGTT بدي يطلع السكر عنده
+
+364
+00:29:52,510 --> 00:29:58,910
+110 أو أقل عشان أقدر أحكي عنه طبيعي أما النقطة
+
+365
+00:29:58,910 --> 00:30:03,030
+التالتة سيبوني من النقطة التانيةالنقطة التالتة
+
+366
+00:30:03,030 --> 00:30:07,150
+بتقولّي «embarred glucose tolerance» كلمة
+
+367
+00:30:07,150 --> 00:30:12,810
+«embarred» معناه يعني فيه خلل، فيه مشكلة ممكن أحكي
+
+368
+00:30:12,810 --> 00:30:16,930
+عنها الـpre-diabetic، تمام؟ «embarred» معناه خلل
+
+369
+00:30:16,930 --> 00:30:23,080
+أو مشكلة في الـglucose tolerance«الشخص يعتمد لديه
+
+370
+00:30:23,080 --> 00:30:27,540
+تحرير الجلوكوز» متى بقول عن هذا الشخص عنده تحرير
+
+371
+00:30:27,540 --> 00:30:32,080
+عنده مشكلة في الجلوكوز توليرانس ‏when the two our
+
+372
+00:30:32,080 --> 00:30:36,340
+glucose results from the oral glucose tolerance
+
+373
+00:30:36,340 --> 00:30:41,040
+test are greater than or equal مية وأربعين
+
+374
+00:30:47,580 --> 00:30:52,640
+لو اعملت لشخص فحص الـ Orange Glucose Tolerance
+
+375
+00:30:52,640 --> 00:30:57,900
+Test تمام؟ وبعد ما أعطيته جرعة السكر بساعتين
+
+376
+00:30:57,900 --> 00:31:05,230
+فحصتله السكرطلعت النتيجة ما بين الـ140 للـ200 يعني
+
+377
+00:31:05,230 --> 00:31:10,510
+بهذه الحدود Range ما بين الـ140 والـ200 milligram
+
+378
+00:31:10,510 --> 00:31:14,770
+per deciliter بحكي عن هذا الشخص الـpre-diabetic
+
+379
+00:31:14,770 --> 00:31:19,310
+إيش يعني pre-diabetic؟ يعني هو عنده Emberged عنده
+
+380
+00:31:19,310 --> 00:31:24,460
+خلل، عنده مشكلة، عنده risk factorللإصابة بالسكري
+
+381
+00:31:24,460 --> 00:31:28,600
+في المستقبل فتعطيه حمية تقوليله العب، exercise، ما
+
+382
+00:31:28,600 --> 00:31:32,760
+تاكلش أكلات لأنه احتمال في المستقبل يصير عندك سكري
+
+383
+00:31:32,760 --> 00:31:38,300
+أما النقطة اللي في النص Embered fasting glucose
+
+384
+00:31:38,300 --> 00:31:43,920
+بيقصد فيها فحص ال fasting blood sugar اللي أخدناه
+
+385
+00:31:43,920 --> 00:31:50,130
+أول مرةwhen a person has fasting glucose equal to
+
+386
+00:31:50,130 --> 00:31:56,210
+or greater than 110 and less than 126. This is
+
+387
+00:31:56,210 --> 00:32:00,070
+considered a risk factor for future diabetes. هذا
+
+388
+00:32:00,070 --> 00:32:05,010
+الإنسان اللي جيت عملتله fasting blood sugar وطلع
+
+389
+00:32:05,010 --> 00:32:10,710
+ما بين 110 و126 milligram per deciliter، هذا بقول
+
+390
+00:32:10,710 --> 00:32:15,570
+عنه pre-diabetic، بقول عنه impaired.إذاً كل فحصية
+
+391
+00:32:15,570 --> 00:32:22,130
+جماعة
+اللي لديها عدد عادل خاص فيه آخر slide
+
+392
+00:32:22,130 --> 00:32:28,850
+الـDiabetes هذا الـNormal Range الخاص في الـOGTT
+
+393
+00:32:28,850 --> 00:32:33,450
+إذا كان شخص يمتلك الـDiabetes وإن أمر الجلوكوز
+
+394
+00:32:33,450 --> 00:32:38,370
+توليرانس تست شهر إن مستوى جلوكوز الدم
+في ساعات هو
+
+395
+00:32:38,370 --> 00:32:44,150
+أكتر من 200 ملي جرام في ديسليتر لو شخصبعد ساعتين
+
+396
+00:32:44,150 --> 00:32:49,930
+من إعطاءه جرعة السكر عملتله فحص الـ OGTT ولجات
+
+397
+00:32:49,930 --> 00:32:55,670
+سكره 200 فم فوق إذا هو أكيد مريض سكري وهو
+
+398
+00:32:55,670 --> 00:33:01,040
+Diabetes، تمام؟أخر حاجة الـ gestational diabetes
+
+399
+00:33:01,040 --> 00:33:07,840
+اللي هو سكر الحمل gestational diabetes سكر الحمل a
+
+400
+00:33:07,840 --> 00:33:12,640
+woman has gestational diabetes when she is
+
+401
+00:33:12,640 --> 00:33:17,020
+pregnant and has any two of the following هذا سكر
+
+402
+00:33:17,020 --> 00:33:21,920
+الحمل طبعاً بصيب الستات أكيد الحوامل أثناء فترة
+
+403
+00:33:21,920 --> 00:33:26,870
+الحملand has any two of the following يعني الست
+
+404
+00:33:26,870 --> 00:33:33,370
+الحامل بتقولك بيكون عندها واحدة من هدول الشغلاتلما
+
+405
+00:33:33,370 --> 00:33:38,710
+بدك تعمليلها OGTT الـ 6 الحامل لو طلع عندها الـ
+
+406
+00:33:38,710 --> 00:33:42,310
+fasting blood sugar اللي هي و هي ثايمة لسه و
+
+407
+00:33:42,310 --> 00:33:46,330
+سحبتيلها العينة و طلع ال fasting blood sugar أعلى
+
+408
+00:33:46,330 --> 00:33:52,070
+من 105 و بعد هي أعطتيها جرعة السكر و خلتيها تنتظر
+
+409
+00:33:52,070 --> 00:33:57,890
+ساعة و بعد ساعة حللتيلها السكر و طلع أعلى من 190
+
+410
+00:33:57,890 --> 00:34:05,060
+بقدر أحكي أنه عندها سكر حملأو لو إجت ست حامل
+
+411
+00:34:05,060 --> 00:34:10,760
+وأعطتيها جرعة سكر بعد ساعتين من تناول جرعة السكر
+
+412
+00:34:10,760 --> 00:34:18,600
+لجيت سكرها أعلى من 165 وبعد 3 ساعات سحبت منها عينة
+
+413
+00:34:18,600 --> 00:34:23,900
+ولجيت سكرها أعلى من 145 برضه هي بتكون عندها
+
+414
+00:34:25,000 --> 00:34:30,420
+Gestational Diabetes طبعا يا جماعة ما يخص
+
+415
+00:34:30,420 --> 00:34:33,560
+الـGestational Diabetes فقط بدي أكوا تعرفوا أنه
+
+416
+00:34:33,560 --> 00:34:37,980
+سكر حمل بصيب الستات وهي حوامل أما الـNormal Range
+
+417
+00:34:37,980 --> 00:34:43,720
+اللي توحكته هذا مش مطلوب بالنسبة لسكر الحمل مش
+
+418
+00:34:43,720 --> 00:34:48,700
+مطلوب تمام؟ لأن كل مختبر له Normal Range خاص فيه
+
+419
+00:34:48,700 --> 00:34:52,400
+تمام؟
+
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/ghzD01vMVCg_postprocess.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/ghzD01vMVCg_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..60207ecb276a3e8edfca9a181013afb4d1fd64a1
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/ghzD01vMVCg_postprocess.srt
@@ -0,0 +1,2504 @@
+1
+00:00:00,710 --> 00:00:04,550
+السلام عليكم ورحمة الله وبركاته يعطيكم العافية
+
+2
+00:00:04,550 --> 00:00:08,890
+جميعا ان شاء الله اليوم موضوعنا بعنوان Total
+
+3
+00:00:08,890 --> 00:00:14,390
+Proteins and Albumin Analysisحنحكي عن الـ
+
+4
+00:00:14,390 --> 00:00:18,690
+introduction «Proteins are polymers of amino acids
+
+5
+00:00:18,690 --> 00:00:23,590
+produced by living cells in all forms of life»
+
+6
+00:00:23,590 --> 00:00:28,250
+بيحكيلي إنه البروتينات تركبتها بوليمر من الأحماض
+
+7
+00:00:28,250 --> 00:00:32,910
+الأمينية يعني تركيبة لبروتين سلسلة من الـ amino
+
+8
+00:00:32,910 --> 00:00:37,690
+acid المرتبطة مع بعضها البعض بواسطة الـ peptide
+
+9
+00:00:37,690 --> 00:00:43,010
+bond الرابطة الببتديةالبروتينات بيحكي لـ Produced
+
+10
+00:00:43,010 --> 00:00:48,370
+by living cells بتم تصنيحها من خلال الخلايا الحية
+
+11
+00:00:48,370 --> 00:00:53,030
+The key rules which plasma proteins play in bodily
+
+12
+00:00:53,030 --> 00:00:56,870
+function together with the relative easy of
+
+13
+00:00:56,870 --> 00:01:00,470
+assaying them makes their determination a viable
+
+14
+00:01:00,470 --> 00:01:03,490
+diagnostic tool as well as a way to monitor
+
+15
+00:01:03,490 --> 00:01:08,600
+clinical progress بقوللي إنه بما إنهالبروتينات
+
+16
+00:01:08,600 --> 00:01:12,760
+الموجودة في بلازمة الدم تلعب دور مهم في الـbody
+
+17
+00:01:12,760 --> 00:01:17,980
+function يعني إلها وظائف جوّات الجسم وأيضا من
+
+18
+00:01:17,980 --> 00:01:24,020
+السهولة أن نحسب أن نحسب تركيز الـtotal protein في
+
+19
+00:01:24,020 --> 00:01:30,710
+هذه البلازمة في الدمهذا أدى كله إلى جعل فحص الـ
+
+20
+00:01:30,710 --> 00:01:36,990
+Total Protein Test فحص Available له قيمة مهم جدا
+
+21
+00:01:36,990 --> 00:01:43,650
+إنه نعمله كأداة تشخيصية لمراقبة ومتابعة الحالات
+
+22
+00:01:43,650 --> 00:01:44,410
+السريرية
+
+23
+00:01:47,530 --> 00:01:51,210
+نكمل بالـ introduction in very general terms
+
+24
+00:01:51,210 --> 00:01:55,370
+variations in plasma protein concentrations can be
+
+25
+00:01:55,370 --> 00:02:00,590
+due to any of the three changes بيحكيلي يعني جبل
+
+26
+00:02:00,590 --> 00:02:05,370
+ما نبدأ بهذه الجملة الـ concentration الطبيعي للـ
+
+27
+00:02:05,370 --> 00:02:09,030
+total protein أنا عندي فحص اسمه total protein test
+
+28
+00:02:09,560 --> 00:02:13,940
+فالـ Total Protein اللي موجودة في البلازمة تاعتنا
+
+29
+00:02:13,940 --> 00:02:22,980
+تركيزها تقريبا من 6.6 لـ 8.4 جرام per deciliter
+
+30
+00:02:22,980 --> 00:02:28,040
+الوحدة بالجرام per deciliter إذا من 6 لـ 8 جرام
+
+31
+00:02:28,040 --> 00:02:32,260
+per deciliter تركيز كل البروتينات في بلازمة الدم
+
+32
+00:02:32,820 --> 00:02:37,600
+هذا ممكن التركيز يصير فيه fluctuation يعني مرة
+
+33
+00:02:37,600 --> 00:02:42,520
+يزيد مرة يجل طبعا بيزيد و بيجل يعني هذه حالات
+
+34
+00:02:42,520 --> 00:02:45,800
+مرضية الإنسان الطبيعي بدي يكون ال range ضمن
+
+35
+00:02:45,800 --> 00:02:49,940
+التركيز ضمن ال normal range أما يزيد و يجل معناه
+
+36
+00:02:49,940 --> 00:02:56,260
+عنا مشكلةفهنا بيحكيلي الـ Variations، الاختلاف في
+
+37
+00:02:56,260 --> 00:03:02,040
+تركيز الـ Total Protein في الـ Plasma ناشئ عن سبب
+
+38
+00:03:02,040 --> 00:03:08,360
+من الأسباب القاتلة إما يكون عندي مشكلة في معدل
+
+39
+00:03:08,360 --> 00:03:15,110
+تصنيع البروتينات خلل في معدل التصنيعأو عندي خلل في
+
+40
+00:03:15,110 --> 00:03:20,850
+معدل التخلص من البروتينات في الجسم the rate of
+
+41
+00:03:20,850 --> 00:03:26,050
+removal أو ممكن يكون عندي مشكلة في volume of
+
+42
+00:03:26,050 --> 00:03:31,500
+distributionفي توزيع هادي لبروتينات موجودة في
+
+43
+00:03:31,500 --> 00:03:36,780
+البلازما أخر جزئية بدنا نفهم كيف الست الحامل الـ
+
+44
+00:03:36,780 --> 00:03:39,660
+Pregnant Woman عندها two circulation الـ blood
+
+45
+00:03:39,660 --> 00:03:43,120
+تبعها عندها two circulation الـ circulation تبعها
+
+46
+00:03:43,120 --> 00:03:46,280
+الدورة الدموية تاعتها و تاعت الطفل تمام؟ و تاعت
+
+47
+00:03:46,280 --> 00:03:52,290
+الجنينمعنى الكلام هيكون عند الست الحامل بلازمة
+
+48
+00:03:52,290 --> 00:03:56,470
+أكتر من الوضع الطبيعي يعني الـ Volume of بلازمة
+
+49
+00:03:56,470 --> 00:04:01,050
+عند الست الحامل هيكون أكتر من الطبيعي حجم البلازمة
+
+50
+00:04:01,050 --> 00:04:06,690
+ذات لما يزيد حجم البلازمة معناه الـ Total Protein
+
+51
+00:04:06,690 --> 00:04:11,450
+اللي موجودة جوات البلازمة هتتخفف، تمام؟ إنسان
+
+52
+00:04:11,450 --> 00:04:16,160
+طبيعي عنده البلازمة حجمها طبيعيوبالتالي الـ Total
+
+53
+00:04:16,160 --> 00:04:20,480
+Protein هتكون طبيعية جوا البلازمة أما الست الحامن
+
+54
+00:04:20,480 --> 00:04:25,220
+حجم البلازمة عندها زادت بسبب وجود Two-circulation
+
+55
+00:04:25,220 --> 00:04:29,120
+الـ circulation الخاصة فيها أو الخاصة بالجنين أدى
+
+56
+00:04:29,120 --> 00:04:33,620
+إلى تخفيف تركيز الـ Total Protein اللي موجودة في
+
+57
+00:04:33,620 --> 00:04:41,180
+البلازمة إذاً هدول تلت شغلات عملوا تغيير في تركيز
+
+58
+00:04:41,180 --> 00:04:46,860
+الـ Total Proteinproteins common properties بدنا
+
+59
+00:04:46,860 --> 00:04:50,620
+نحكي عن بعض خصائص البروتينات in spite of
+
+60
+00:04:50,620 --> 00:04:53,920
+functional differences between the various ceramic
+
+61
+00:04:53,920 --> 00:04:58,060
+proteinsThey have certain common biophysical and
+
+62
+00:04:58,060 --> 00:05:01,840
+biochemical properties these include على الرغم من
+
+63
+00:05:01,840 --> 00:05:06,820
+أن البروتينات مختلفة عن بعضها البعض من حيث الـ
+
+64
+00:05:06,820 --> 00:05:12,500
+function من حيث الوظيفة إلا إن في هناك خصائص كيمية
+
+65
+00:05:12,500 --> 00:05:18,800
+وفيزيائية كل بروتينات تشترك فيها، تمام؟يعني بتلاقي
+
+66
+00:05:18,800 --> 00:05:22,480
+بروتين وبروتين بيكون لهم نفس الخصائص الكيميائية
+
+67
+00:05:22,480 --> 00:05:27,660
+والفيزيائية لكن إيه بيختلفوا في الوظيفة من أشهر
+
+68
+00:05:27,660 --> 00:05:32,160
+هذه الخصائص اللي هنستعرضها مع بعض هي خصائص يعني
+
+69
+00:05:32,160 --> 00:05:37,840
+تنتبق على كل بروتينات بغض النظر عن وظيفة هذا
+
+70
+00:05:37,840 --> 00:05:43,140
+لبروتين أول خاصية A basic composition of carbon,
+
+71
+00:05:43,300 --> 00:05:47,160
+hydrogen, nitrogen and oxygenكلنا عارفين إن
+
+72
+00:05:47,160 --> 00:05:51,480
+البروتين عبارة عن أحماض أمينية مرتبطة مع بعض غالب
+
+73
+00:05:51,480 --> 00:05:55,700
+بعض بـpeptide bond صح ولا لأ؟ هلجيت الأحماض
+
+74
+00:05:55,700 --> 00:05:59,560
+الأمينية الـ amino acid شو تركيب الأحماض الأمينية؟
+
+75
+00:05:59,560 --> 00:06:04,600
+الأحماض الأمينية تتركب من أربع عناصر أساسية داخلة
+
+76
+00:06:04,600 --> 00:06:08,360
+في تركيب الأحماض الأمينية Carbon، Hydrogen،
+
+77
+00:06:08,360 --> 00:06:13,900
+Nitrogen، Oxygenإذاً كل بروتينات فيها أحماض أمينية
+
+78
+00:06:13,900 --> 00:06:19,020
+وتركيبة الأحماض الأمينية عبارة عن أربع ناصر
+
+79
+00:06:19,020 --> 00:06:25,650
+Hydrogen, Carbon, Nitrogen and Oxygenتمام الخاصية
+
+80
+00:06:25,650 --> 00:06:29,730
+التانية «Pig bone of covalent-peptide bond which
+
+81
+00:06:29,730 --> 00:06:33,250
+joined amino acid units together» حكيناها إن كل
+
+82
+00:06:33,250 --> 00:06:37,750
+بروتينات عبارة عن سلسلة من الأحماض الأمينية مرتبطة
+
+83
+00:06:37,750 --> 00:06:42,490
+مع بعضها البعض بـpeptide bondتالت خاصية Absorption
+
+84
+00:06:42,490 --> 00:06:48,010
+Maximum in the Ultraviolet Region كل بروتينات
+
+85
+00:06:48,010 --> 00:06:55,170
+بيصيرلها أعلى انتصاص بتنتص الضوء المسلط عليها في
+
+86
+00:06:55,170 --> 00:07:01,230
+منطقة الـ UV المنطقة الفوق بنفسها Ultraviolet من
+
+87
+00:07:01,230 --> 00:07:08,270
+280 لـ 340 نانومتر كل بروتينات بيصيرلها انتصاص في
+
+88
+00:07:08,270 --> 00:07:09,950
+هذه المنطقة
+
+89
+00:07:12,130 --> 00:07:17,050
+بنكمل مع بعض proteins common properties based on
+
+90
+00:07:17,050 --> 00:07:19,850
+these properties laboratory methods have been
+
+91
+00:07:19,850 --> 00:07:22,310
+developed to determine the concentration of
+
+92
+00:07:22,310 --> 00:07:25,850
+proteins in serum often with the assumption that
+
+93
+00:07:26,730 --> 00:07:33,330
+بناء واعتماد على خصائص البروتينات كلها الخصائص
+
+94
+00:07:33,330 --> 00:07:39,930
+الاستعرضناها قبل شوية تم تطوير طرق مخبرية مختلفة
+
+95
+00:07:39,930 --> 00:07:44,610
+من خلال هذه الطرق سيتم حساب تركيز الـ Total
+
+96
+00:07:44,610 --> 00:07:50,130
+Protein في الـ Plasma الدمتحت فيه عبارة، each of
+
+97
+00:07:50,130 --> 00:07:54,010
+the several hundred individual proteins present in
+
+98
+00:07:54,010 --> 00:07:59,990
+serum reacts similar in chemical reaction يا جماعة
+
+99
+00:07:59,990 --> 00:08:04,110
+السيرم أو البلازمة تحت الدم فيها مئات من
+
+100
+00:08:04,110 --> 00:08:07,830
+البروتينات يعني أنواع مختلفة من البروتينات hundred
+
+101
+00:08:07,830 --> 00:08:13,830
+proteins هذه البروتيناتتفاعلاتها كلها Similar،
+
+102
+00:08:13,830 --> 00:08:17,630
+بتكون متشابهة الـ Chemical reaction بتاعتها،
+
+103
+00:08:17,630 --> 00:08:22,490
+التفاعلات الكيميائية بتاعتها كلها بتكون متشابهة و
+
+104
+00:08:22,490 --> 00:08:27,110
+هي نفسها، تمام؟ لأن أصلا الحكينا لبروتينات يعني
+
+105
+00:08:27,110 --> 00:08:31,710
+إلها خصائص فيزيائية و كيميائية مشتركة لكن بتختلف
+
+106
+00:08:31,710 --> 00:08:38,910
+في وظائفها، كل بروتين بيقدّي وظيفة مختلفةفحصنا
+
+107
+00:08:38,910 --> 00:08:45,550
+اليوم اسمه Serum Total Protein Test سواء حكيت
+
+108
+00:08:45,550 --> 00:08:51,350
+Serum Total Protein Test أو Plasma Total Protein
+
+109
+00:08:51,350 --> 00:08:56,330
+Test أو Total Protein Test هذه أسماء مختلفة للفحص
+
+110
+00:08:56,330 --> 00:09:00,630
+احنا عادة بنحكي Total Protein Test عالسريع لأنه
+
+111
+00:09:00,630 --> 00:09:04,900
+انا بدي احسبتركيز كل بروتينات الموجودة في بلازمة
+
+112
+00:09:04,900 --> 00:09:09,740
+الدم هذا الفحص is a biochemical test فحص كيميائي
+
+113
+00:09:09,740 --> 00:09:15,480
+بيقيص الـ total amount of protein in blood plasma
+
+114
+00:09:15,480 --> 00:09:21,480
+or serum هذا فحص كيميائي بيقيص تركيز كل بروتينات
+
+115
+00:09:21,480 --> 00:09:25,560
+الموجودة سواء في بلازمة الدم أو في الـ serum تبع
+
+116
+00:09:25,560 --> 00:09:33,320
+الدم تمام؟Total Protein Test Can Reflect يعني ليش
+
+117
+00:09:33,320 --> 00:09:37,700
+يعني هنا بنطرح سؤال ليش الدكتور بطلب فحص الـ Total
+
+118
+00:09:37,700 --> 00:09:40,680
+Protein Test؟ ليش بديعرف تركيز الـ Total Protein
+
+119
+00:09:40,680 --> 00:09:45,420
+في الـ Plasma قدّام؟ لتلت أسباب، عشان نشيك على الـ
+
+120
+00:09:45,420 --> 00:09:51,250
+Nutritional Status حالة التخزين عند المريضحكينا
+
+121
+00:09:51,250 --> 00:09:58,130
+إنه البروتينات إلها مصدرين إن خلايا جوات الجسم
+
+122
+00:09:58,130 --> 00:10:02,750
+وبالأخص الـ liver خلايا الكبد هي المسؤولة عن تصنيع
+
+123
+00:10:02,750 --> 00:10:07,030
+البروتينات إذا البروتينات مصدره داخلي الخلايا هي
+
+124
+00:10:07,030 --> 00:10:11,430
+اللي بتصنعه وإنه مصدر آخر البروتين إنه إحنا بنحصل
+
+125
+00:10:11,430 --> 00:10:15,730
+عليه من الـ diet من الأكلات مثلا من اللثوم صح ولا
+
+126
+00:10:15,730 --> 00:10:21,200
+لأ؟اللحوم مليانة بروتينات مثلًا شخص ما بياكل لحمة
+
+127
+00:10:21,200 --> 00:10:24,960
+جينا يعني أي إشي البقليات اللحوم اللي فيها
+
+128
+00:10:24,960 --> 00:10:28,580
+بروتينات ما بياكلها بالمرة جينا فحصنا له الـ total
+
+129
+00:10:28,580 --> 00:10:34,360
+protein لجناه واطي كتير طيب هل واطي لإنه عنده
+
+130
+00:10:34,360 --> 00:10:38,820
+مشكلة في الكبد مثلًا إنه ما بيصنع البروتينات أو
+
+131
+00:10:38,820 --> 00:10:42,960
+لإنه عنده سوء التغذية malnutrition يعني عنده سوء
+
+132
+00:10:42,960 --> 00:10:47,240
+التغذيةإذا أنا من خلال فحص الـ Total Protein بقدر
+
+133
+00:10:47,240 --> 00:10:52,220
+أعرف هذا الشخص عنده سوق تغذية ولا غزاقه تمام تاني
+
+134
+00:10:52,220 --> 00:10:56,460
+شغلة بشيك على ال kidney disease بشيك على الكلة
+
+135
+00:10:56,460 --> 00:11:01,240
+كلنا عارفين أن البروتين زيه زي الجلوكوز أخدته في
+
+136
+00:11:01,240 --> 00:11:07,530
+السوائل عنصر مهم للجسمممنوع يطلع عن طريق الكيلة مع
+
+137
+00:11:07,530 --> 00:11:11,430
+الـ urine يجب إعادة انتصاصه يعني الكيلة بدها تعمل
+
+138
+00:11:11,430 --> 00:11:16,130
+للبروتينات reabsorption وترجعها على الدم طيب لو
+
+139
+00:11:16,130 --> 00:11:18,830
+البروتين لجته في الـ urine في الـ strip الـ urine
+
+140
+00:11:18,830 --> 00:11:23,990
+لجت في بروتينمعناه في عندي مشكلة في الـ kidney إذا
+
+141
+00:11:23,990 --> 00:11:28,250
+فحص الـ total protein يشيك على الـ kidney أيضا
+
+142
+00:11:28,250 --> 00:11:32,730
+يشيك على liver disease لأنه أصلا من المصنع اللي في
+
+143
+00:11:32,730 --> 00:11:37,170
+الجسم بيصنع البروتينات حكينا إنه ال liver فأنا
+
+144
+00:11:37,170 --> 00:11:42,130
+بشيك على الكبد من خلال أني أعمل فحص الـ total
+
+145
+00:11:42,130 --> 00:11:42,930
+protein
+
+146
+00:11:45,270 --> 00:11:51,590
+البروتين في البلازمة مصممة من ألبومين و Globulins
+
+147
+00:11:51,590 --> 00:11:56,330
+عندي قاعدة، عندي معادلة كلنا بدنا نعرفها إن الـ
+
+148
+00:11:56,330 --> 00:12:00,670
+Total Protein في البلازمة إيش بتساوي؟ بتساوي
+
+149
+00:12:00,670 --> 00:12:06,520
+الألبومين ذائد ال Globulinحكينا إن الـ albumin نوع
+
+150
+00:12:06,520 --> 00:12:11,020
+من أنواع البروتينات موجود في بلازمة الدم وموجود
+
+151
+00:12:11,020 --> 00:12:16,540
+بأعلى تركيز يعني هو المسيطر في البلازمة يعني نص
+
+152
+00:12:16,540 --> 00:12:21,220
+البروتينات اللي موجودة في بلازمة الدم عبارة عن
+
+153
+00:12:21,220 --> 00:12:26,060
+albumin فالـ total protein بساوي ال albumin ذات
+
+154
+00:12:26,060 --> 00:12:29,720
+الglobulin إذا النص الـ total protein اللي في
+
+155
+00:12:29,720 --> 00:12:35,360
+البلازمة عبارة عن albuminوالنُص التاني عبارة عن
+
+156
+00:12:35,360 --> 00:12:40,560
+الـ Globulins البروتينات هي Iglobulin الـ Globulin
+
+157
+00:12:40,560 --> 00:12:45,060
+برضه هذا البروتين فيه منه fraction فيه منه أنواع
+
+158
+00:12:45,060 --> 00:12:50,300
+الـ Alpha 1 Globulin الـ Alpha 2 Globulin الـ Beta
+
+159
+00:12:50,300 --> 00:12:55,440
+Globulin والـ Gamma Globulin إذا نفهم من أول نقطة
+
+160
+00:12:56,230 --> 00:13:00,310
+إن الـ Total Protein بتساوي الـAlbumin زائد
+
+161
+00:13:00,310 --> 00:13:03,550
+الـGlobulin الـAlbumin بشكل نص الـTotal Protein
+
+162
+00:13:03,550 --> 00:13:08,190
+الـGlobulin عبارة عن أربع fraction بضم الـAlpha 1
+
+163
+00:13:08,190 --> 00:13:14,770
+والـAlpha 2 والـBeta والـGamma Globulins تمام؟ هذه
+
+164
+00:13:14,770 --> 00:13:18,970
+الـFractions هذه الأقسام الـAlbumin وأنواع
+
+165
+00:13:18,970 --> 00:13:24,210
+الـGlobulinsCan be quantitated using a protein
+
+166
+00:13:24,210 --> 00:13:27,630
+electrophoresis يعني انا ممكن اعرف تركيز ال album
+
+167
+00:13:27,630 --> 00:13:32,710
+تركيز Alpha 1 Alpha 2 و Beta و Gamma من خلال ال
+
+168
+00:13:32,710 --> 00:13:36,050
+Electrophoresis وهذا سيأخذه سنة رابعة الفصل
+
+169
+00:13:36,050 --> 00:13:42,240
+التانيةنفصلهم على الـ cellulose acetate أو على
+
+170
+00:13:42,240 --> 00:13:47,100
+الجل ونشوف الباندات الخامسة الألبومين الألف وان
+
+171
+00:13:47,100 --> 00:13:51,560
+الألف اتو البيتا الجامعة يعني أنا بحسب في الآخر
+
+172
+00:13:51,560 --> 00:13:56,720
+تركيزهمBut the total protein test أما الفحص
+
+173
+00:13:56,720 --> 00:14:01,040
+الكيمياء البسيط اللي هو الـ Total Protein is
+
+174
+00:14:01,040 --> 00:14:05,460
+faster and cheaper أسرع من الـ Electrophoresis
+
+175
+00:14:05,460 --> 00:14:10,200
+أكيد يعني خلال عشر دقائق بتكون مخلصة الفحص and
+
+176
+00:14:10,200 --> 00:14:14,800
+cheaper وأرخص أكيد ال Electrophoresis غاليthat
+
+177
+00:14:14,800 --> 00:14:19,480
+estimates هذا الفحص يقدر لنا الـ total of all
+
+178
+00:14:19,480 --> 00:14:25,240
+fractions together بيقدر لنا جداش تركيز كل
+
+179
+00:14:25,240 --> 00:14:28,420
+البروتينات الموجودة في البلازمة يعني جداش تركيز
+
+180
+00:14:28,420 --> 00:14:31,820
+الألبوم اللي مع Alpha 1 و Alpha 2 و Beta و Gamma
+
+181
+00:14:31,820 --> 00:14:34,180
+كلهم مع بعض جداش تركيزهم
+
+182
+00:14:45,650 --> 00:14:51,210
+الطريقة التقليدية لقياس تركيز كل بروتينات في
+
+183
+00:14:51,210 --> 00:14:55,530
+البلازمة اسمها الـPyrite method طريقة الـPyrite
+
+184
+00:14:55,530 --> 00:15:01,570
+لكن في طرق كيمية أخرى هنستعرضها مع بعضMethods of
+
+185
+00:15:01,570 --> 00:15:07,910
+Total Protein Analysis طرق مختلفة من أجل حساب الـ
+
+186
+00:15:07,910 --> 00:15:12,650
+Total Protein في بلازمة الدم أول طريقة هي الـ Kill
+
+187
+00:15:12,650 --> 00:15:15,630
+-dial method هذه طريقة reference method طريقة
+
+188
+00:15:15,630 --> 00:15:19,130
+مرجعية إلا أنها لا تستخدم كثيرا لأنها تحتاج
+
+189
+00:15:19,130 --> 00:15:23,950
+متطلبات خاصةطريقة quantitative يعني بتعطيك تركيز
+
+190
+00:15:23,950 --> 00:15:28,190
+الـ Total Protein بدقة هذه الطريقة ما بتجيس الـ
+
+191
+00:15:28,190 --> 00:15:32,310
+Total Protein الموجود في بلازمة الدم بشكل Direct
+
+192
+00:15:32,310 --> 00:15:36,230
+بشكل Direct، ما بتقيصه إنما بتقيس الـ Total
+
+193
+00:15:36,230 --> 00:15:40,730
+Protein بشكل indirect، بشكل غير مباشر طيب، هي إيش
+
+194
+00:15:40,730 --> 00:15:45,210
+بتجيس بالظبط؟ بتجيس تركيز الـ Nitrogen اللي داخل
+
+195
+00:15:45,210 --> 00:15:49,910
+في تركيب الـ Amino Acidاللي أصلاً داخل في تركيب
+
+196
+00:15:49,910 --> 00:15:55,370
+البروتين نفسهمش حاكينا الـ Amino Acid تركيبته
+
+197
+00:15:55,370 --> 00:15:59,490
+الأساسية Nitrogen و Oxygen و Carbon و Hydrogen
+
+198
+00:15:59,490 --> 00:16:03,070
+فهذه طريقة الـ Keldal بتقيس تركيز الـ Nitrogen
+
+199
+00:16:03,070 --> 00:16:08,730
+الداخل في تركيب الـ Amino Acid وتركيز الـ Nitrogen
+
+200
+00:16:08,730 --> 00:16:14,510
+يعبر عن تركيز الـ Total Protein فقط، هيها بكل
+
+201
+00:16:14,510 --> 00:16:18,850
+بساطة طبعاً مش هطلبكوا بأي تفصيل يعني اللي حكيته
+
+202
+00:16:18,850 --> 00:16:22,740
+هذا فقط للعلمأكيد الدكتور مازين هيعطيكوا إياها
+
+203
+00:16:22,740 --> 00:16:27,820
+بالتفصيل، تمام؟ الـ Ultraviolet Absorption إذا
+
+204
+00:16:27,820 --> 00:16:31,960
+الكل دا كانت بلكوا Quantitative بروتين نيتروجين
+
+205
+00:16:31,960 --> 00:16:36,660
+Determination يعني بقيس تركيز النيتروجين الداخل في
+
+206
+00:16:36,660 --> 00:16:41,220
+تركيب الأحماض الأمينية اللي موجودة في تركيب
+
+207
+00:16:41,220 --> 00:16:46,160
+البروتين نفسه Ultraviolet Absorption هذه برضه
+
+208
+00:16:46,160 --> 00:16:52,290
+بيكون عندى كت خاص للـ Total Proteinوهذا الـ Kit
+
+209
+00:16:52,290 --> 00:16:57,790
+مصمم إن الـ Total Protein يتم قراءتها على الـ
+
+210
+00:16:57,790 --> 00:17:02,110
+Ultraviolet على المنطقة الفوق بنفس جهة وكتبلكوا
+
+211
+00:17:02,110 --> 00:17:07,290
+الـ Absorption بيكون على 210 نانومتر وبرضه طريقة
+
+212
+00:17:07,290 --> 00:17:10,950
+quantitative إلها طبعا يا بنات خطوات و procedure
+
+213
+00:17:10,950 --> 00:17:15,660
+في ال Kit بيكون في الورقة اللي مع ال Kitطريقة
+
+214
+00:17:15,660 --> 00:17:21,120
+تالتة Refractometry بشكل مبسط طريقة quantitative
+
+215
+00:17:21,120 --> 00:17:25,080
+برضه بتعطيك التركيز دقيق هذا عبارة عن
+
+216
+00:17:25,080 --> 00:17:29,640
+Refractometry عبارة عن جهاز أنت بتحط فيه عينة الـ
+
+217
+00:17:29,640 --> 00:17:32,920
+Serum أو البلازمة طبعاً البلازمة أو الـ Serum فيها
+
+218
+00:17:32,920 --> 00:17:37,620
+الـ Total Proteins كلها تحطيها جوات الجهاز الجهاز
+
+219
+00:17:37,620 --> 00:17:41,640
+هذا بيروح يسلط ضوء أو شعاع على الـ Serum على
+
+220
+00:17:41,640 --> 00:17:47,910
+العينةجدّاش في عندك Total Protein جوات البلازمة أو
+
+221
+00:17:47,910 --> 00:17:53,270
+الـ Serum هذه البروتينات أول ما يصلها الضوء هتعمل
+
+222
+00:17:53,270 --> 00:17:59,010
+تشتت لهذا الضوء، هينكسر الضوء، تمام؟ وفي ديتكتور
+
+223
+00:17:59,010 --> 00:18:05,000
+في هذا الجهاز بقيس زاوية الانكساركل ما كانت مقدار
+
+224
+00:18:05,000 --> 00:18:11,160
+زاوية الانكسار عالية كتير وكبيرة هذا مؤشر إن الـ
+
+225
+00:18:11,160 --> 00:18:15,220
+Total Protein اللي موجودة في البلازما تركيزها عالي
+
+226
+00:18:15,220 --> 00:18:21,800
+فكسرت الضوء اللي مصلط عليها بشكل أكبر وبشكل أكتر،
+
+227
+00:18:21,800 --> 00:18:26,020
+تمام؟ هذا بكل بساطة اللي بدنا نعرفهوبرضه مش
+
+228
+00:18:26,020 --> 00:18:29,920
+مطالبين هنا في العمل بس في النظر أكيد مطالبين فيه
+
+229
+00:18:29,920 --> 00:18:34,240
+طريقتنا المطالبين نعرف عنها هي الطريقة الرابعة الـ
+
+230
+00:18:34,240 --> 00:18:37,860
+Pyrite Method هناخدها بالسلايدات الجاية طريقة
+
+231
+00:18:37,860 --> 00:18:42,600
+quantitative والانتصاص للـ total protein بيكون على
+
+232
+00:18:42,600 --> 00:18:48,400
+540 نانومتر طريقة الـ dye binding طريقة بسيطة جدا
+
+233
+00:18:49,600 --> 00:18:53,080
+طبعاً الـ Serum بيكون فيه الـ Total بروتين اللي
+
+234
+00:18:53,080 --> 00:18:57,420
+بدي أجيسها و الـ Reagent بيكون فيه dye بيكون فيه
+
+235
+00:18:57,420 --> 00:19:01,940
+سبغة هذه السبغة تربط مع كل بروتينات و بيعطوني
+
+236
+00:19:01,940 --> 00:19:08,470
+Complex ملون و بيتم قياس هذا ال Complex الملونالـ
+
+237
+00:19:08,470 --> 00:19:14,450
+Total Nitrogen هذه طريقة بتم فيها قياس تركيز الـ
+
+238
+00:19:14,450 --> 00:19:20,770
+Nitrogen اللي داخل في تركيب البروتين وقياس تركيز
+
+239
+00:19:20,770 --> 00:19:26,590
+الـ Nitrogen اللي داخل في مركبات أخرى غير البروتين
+
+240
+00:19:27,190 --> 00:19:30,910
+بدنا نفهم شغلة ان الـ nitrogen مش بس بيدخل في
+
+241
+00:19:30,910 --> 00:19:35,430
+تركيب لبروتينات لأ بيدخل فيه مركبات أخرى فهذه
+
+242
+00:19:35,430 --> 00:19:38,430
+الطريقة تعطي الـ total nitrogen من اسمها total
+
+243
+00:19:38,430 --> 00:19:42,790
+nitrogenيعني بتقيف الـ Nitrogen اللي داخل في تركيب
+
+244
+00:19:42,790 --> 00:19:46,610
+البروتينات وبتقيف الـ Nitrogen اللي داخل في تركيب
+
+245
+00:19:46,610 --> 00:19:51,010
+مركبات أخرى وبحسبة معينة بتم حساب الـ Total
+
+246
+00:19:51,010 --> 00:19:56,630
+البروتين هذه طرق يعني كتيرة، إحنا الشائع عندنا هي
+
+247
+00:19:56,630 --> 00:20:01,030
+الـPiuret Method طبعاً
+
+248
+00:20:01,030 --> 00:20:05,830
+كتاتنا اللي موجودة في مختبرنا بتشتغل بطريقة
+
+249
+00:20:05,830 --> 00:20:11,530
+الـPiuret Methodحتى اسم الـ Reagent اللي بيجي مع
+
+250
+00:20:11,530 --> 00:20:15,570
+الـ Kit اسمه «Pyrite Reagent» تمام؟ إذا أنا بعرف
+
+251
+00:20:15,570 --> 00:20:19,990
+Pyrite Reagent هذا الـ Reagent خاص لقياس تركيز الـ
+
+252
+00:20:19,990 --> 00:20:24,610
+Total بروتين هذا الـ Reagent يا جماعة بتكون من تلت
+
+253
+00:20:24,610 --> 00:20:31,380
+مركبات أساسية الـ Sodium Hydroxide الـ Copperالـ
+
+254
+00:20:31,380 --> 00:20:36,420
+Copper Sulfate و الـ Potassium Sodium Tertarate
+
+255
+00:20:36,420 --> 00:20:41,180
+إذن تلت مركبات أساسية داخلة في تركيب الـ Pyrite
+
+256
+00:20:41,180 --> 00:20:46,600
+Reagent هذا الـ Reagent بيجيني من الشركة لونه أزرق
+
+257
+00:20:46,600 --> 00:20:51,630
+لونه blue color تمام؟هلجيت لما أخلط هذا الـ
+
+258
+00:20:51,630 --> 00:20:55,690
+Reagent أضيفه على الـ Serum تبع المريض اللي جواته
+
+259
+00:20:55,690 --> 00:21:00,470
+بروتينات حيصير فيه تفاعل بين البروتينات الموجودة
+
+260
+00:21:00,470 --> 00:21:05,230
+في ال patient serum و بين الـ Reagent اللي لونه
+
+261
+00:21:05,230 --> 00:21:10,810
+أزرق ومحصلة التفاعل هيتغير اللون من أزرق إلى
+
+262
+00:21:10,810 --> 00:21:15,250
+violet إلى اللون البنفسجي a blue reagent which
+
+263
+00:21:15,250 --> 00:21:19,420
+turns violet in the presence of a proteinلأن الـ
+
+264
+00:21:19,420 --> 00:21:22,820
+Serum جواته بروتين فلمّا تخلط الـ Serum مع الـ
+
+265
+00:21:22,820 --> 00:21:27,540
+Reagent بتحول اللون من اللون الأزرق لللون الـ
+
+266
+00:21:27,540 --> 00:21:32,300
+Violet، البنفسجي، تمام؟ الـ Moveالـ Sodium
+
+267
+00:21:32,300 --> 00:21:39,160
+Hydroxide لا يتفاعل بالتفاعل على الإطلاق، لكنه فقط
+
+268
+00:21:39,160 --> 00:21:45,740
+هناك لإعطاء مواقع ألكولين لإنطلاق التفاعل الفايدة
+
+269
+00:21:45,740 --> 00:21:49,080
+من مادة الـ Sodium Hydroxide الداخلة في تركيب الـ
+
+270
+00:21:49,080 --> 00:21:54,200
+Pyrite Reagent فقط توفير مواقع ألكولين تمام؟ توفير
+
+271
+00:21:54,200 --> 00:22:00,300
+بيئة قاعدية للـ Reagentprincipal pyrite method
+
+272
+00:22:00,300 --> 00:22:05,560
+مبدأ طريقة الـ pyrite بشكل مبسط قبل ما نقرأ الـ
+
+273
+00:22:05,560 --> 00:22:09,160
+slide بدي أحكيلكم و ألخص المبدأ هل جيت الـ Serum
+
+274
+00:22:09,160 --> 00:22:12,260
+إيش فيه؟ فيه الـ total proteins كل البروتينات اللي
+
+275
+00:22:12,260 --> 00:22:16,390
+بدي أحسب تركيزهاهلجيت لبروتينات تركيبها شوية يا
+
+276
+00:22:16,390 --> 00:22:21,050
+جماعة حكينا مجموعة وسلسلة من الـ Amino Acid من
+
+277
+00:22:21,050 --> 00:22:26,210
+الأحماض الأمينية المرتبطة مع بعضها البعض بواسطة
+
+278
+00:22:26,210 --> 00:22:30,550
+روابط بيبتيدية هلجيت لما أنت تجيب الـ Priority
+
+279
+00:22:30,550 --> 00:22:34,790
+Agent الـ Reagent اللي جاي من الشركة و تديريه على
+
+280
+00:22:34,790 --> 00:22:38,870
+الـ Serum تحطيه فوق الـ Serum تمام؟ إيش اللي هيصير
+
+281
+00:22:38,870 --> 00:22:43,930
+بالظبط؟ كيف الـ Reaction بيصير؟هلجيت؟ اتفجنا إن
+
+282
+00:22:43,930 --> 00:22:47,310
+الـ Sodium Hydroxide اللي في الـ Reagent بيوفر
+
+283
+00:22:47,310 --> 00:22:52,530
+بيئة قاعدية للـ Reagent، okayطيب، الـ Copper
+
+284
+00:22:52,530 --> 00:22:56,770
+Sulphate إيش وظيفته؟ الـ Copper Sulphate بيجي على
+
+285
+00:22:56,770 --> 00:23:01,690
+البروتينات بيجي وين فيه بيبتايد بوند، الـ Copper
+
+286
+00:23:01,690 --> 00:23:06,730
+Sulphate بعمل reaction مع الـ peptide bond اللي
+
+287
+00:23:06,730 --> 00:23:11,610
+بتربط الأحماض الأمينية مع بعضها البعض بيجي الـ
+
+288
+00:23:11,610 --> 00:23:15,880
+Copper Sulphate وين فيه بيبتايد bond بربطوهناك في
+
+289
+00:23:15,880 --> 00:23:20,220
+هذه المنطقة الـ Copper Sulphate، الـ Copper نفسه،
+
+290
+00:23:20,220 --> 00:23:25,120
+الـ CuIplus2، بيصيرله reduction، النحاس بيصيرله
+
+291
+00:23:25,120 --> 00:23:32,460
+اختزان، وبيتحول من CuIplus2 إلى CuIplus1، وهنا
+
+292
+00:23:32,460 --> 00:23:38,460
+بيبدأ اللون يتغير، إذًا لما بنحط الـ Reagent، الـ
+
+293
+00:23:38,460 --> 00:23:40,980
+Pyrite Reagent، على عينة السيرم اللي فيها
+
+294
+00:23:40,980 --> 00:23:45,570
+البروتينات،الـ Sodium Hydroxide يوثّر بيه قاعدية
+
+295
+00:23:45,570 --> 00:23:48,750
+هيك الـ reaction بدّه، بدّه alkaline medium تمام
+
+296
+00:23:48,750 --> 00:23:53,170
+الـ Copper Sulphate بيروح على وين فيه بالـ Tight
+
+297
+00:23:53,170 --> 00:23:57,250
+bond روابط بالـ T دي، راطة بين أحماض أمينية بيجوا
+
+298
+00:23:57,250 --> 00:24:02,760
+بربط و بتفاعل معهاوهناك في هذه المنطقة بتحول الـ
+
+299
+00:24:02,760 --> 00:24:08,000
+Cu Plus 2 النحاس Plus 2 إلى Cu Plus 1 يعني بيصير
+
+300
+00:24:08,000 --> 00:24:11,740
+عندنا reduction اختزال أول ما بيصير اختزال في
+
+301
+00:24:11,740 --> 00:24:16,820
+النحاس بتغير لون التفاعل من اللون الأزرق مااحنا
+
+302
+00:24:16,820 --> 00:24:19,960
+اتفجنا الـ Reagent لونه أزرق إلى اللون الـ Violet
+
+303
+00:24:19,960 --> 00:24:23,580
+إذا لما أشوف اللون البنفسجي بحكي آه والله فيه
+
+304
+00:24:23,580 --> 00:24:29,340
+بروتيناتموجودة في الـ Serum وراحت واتفاعلت مع الـ
+
+305
+00:24:29,340 --> 00:24:34,080
+Reagent وأعطت اللون البنفسجي، تمام؟ هالجيت
+
+306
+00:24:34,080 --> 00:24:38,660
+هتسألوني المادة التالتة في الـ Reagent شو عظفتها،
+
+307
+00:24:38,660 --> 00:24:43,560
+اللي اسمها بوتاسيوم، سوديوم، ترتاريت، هذه المادة
+
+308
+00:24:43,560 --> 00:24:49,580
+تشتغل كـ Stabilizer لـ Violet Color، بتثبت اللون
+
+309
+00:24:49,580 --> 00:24:53,700
+البنفسجي، يعني هالجيت لما صار في reaction، تفاعل،
+
+310
+00:24:53,740 --> 00:24:57,760
+بين الـ Reagent والـ Serum نتج لون عشان هذا اللون
+
+311
+00:24:57,760 --> 00:25:02,540
+مايروح بسرعة في إن مادة في الـ Reagent اسمها
+
+312
+00:25:02,540 --> 00:25:06,180
+Botassium Sodium Tertarate تعمل Stabilizer للمادة
+
+313
+00:25:06,180 --> 00:25:11,520
+بتثبت للمادة وبتخليها لمدة ساعة، تمام؟ عشان انت
+
+314
+00:25:11,520 --> 00:25:18,440
+خلال هذه الساعة تقدر تجيثي التفاعل
+
+315
+00:25:18,440 --> 00:25:23,820
+ع جهاز الـ Spectrophotometer، تمام؟نقرأ السلايدات
+
+316
+00:25:23,820 --> 00:25:29,460
+ببتايت بوند أوفي بروتيين تتعامل مع ترترات
+
+317
+00:25:29,460 --> 00:25:34,960
+كومبليكست كابريك ايون ان ألكالين سوليوشن لتصميم
+
+318
+00:25:34,960 --> 00:25:38,900
+نوع من البرودكت اللي برنسبل زي ما أنا حكيتلكوا
+
+319
+00:25:38,900 --> 00:25:41,760
+بيها بالظبط أن وين فيه ببتايت بوند بيجي
+
+320
+00:25:41,760 --> 00:25:45,960
+الكابرسالفيت بربط فيها بعطيني لهم بنفس تجه مين
+
+321
+00:25:45,960 --> 00:25:51,140
+بيعمله الـ Stabilizer الترتراتإن a positive test
+
+322
+00:25:51,140 --> 00:25:56,020
+في الفحص الـ Positive copper plus 2 ion is reduced
+
+323
+00:25:56,020 --> 00:26:00,240
+to copper 1 حكيتلكوا بصير اختزال which forms a
+
+324
+00:26:00,240 --> 00:26:04,180
+complex with the nitrogens and carbons of the
+
+325
+00:26:04,180 --> 00:26:08,120
+peptide bond in alkaline solution شغلات حكيها مش
+
+326
+00:26:08,120 --> 00:26:11,960
+كتير واضحة بس المبدأ نفس ما أنا حكيتلكوا معاها
+
+327
+00:26:11,960 --> 00:26:15,960
+تمام؟ a violet color indicates the presence of a
+
+328
+00:26:15,960 --> 00:26:18,560
+protein اللون اللي بنفسه يعني حد استفاعله فيه
+
+329
+00:26:18,560 --> 00:26:21,900
+بروتيناتThe intensity of color هلجيه اللون
+
+330
+00:26:21,900 --> 00:26:27,520
+البنفسجي اللي ظهر شدة اللون تتناسب تناسب طرده مع
+
+331
+00:26:27,520 --> 00:26:31,520
+تركيز الـ total protein اللي موجود في البلازما
+
+332
+00:26:32,540 --> 00:26:38,520
+بيصيرله طبعًا absorption انتصاف على 546 أو ما بين
+
+333
+00:26:38,520 --> 00:26:43,600
+الـ520 و570 بتناسب تناسب ترضي معه الـprotein
+
+334
+00:26:43,600 --> 00:26:46,680
+concentration يعني لما يكون اللون الناتج عن
+
+335
+00:26:46,680 --> 00:26:50,700
+التفاعل move غامج معناه أنا لحالي بحكي والله
+
+336
+00:26:50,700 --> 00:26:55,350
+هالجات حيطلع الـtotal protein عاليلما يكون move
+
+337
+00:26:55,350 --> 00:26:58,210
+طبيعي بحكي والله الـ total protein عند هذا ال
+
+338
+00:26:58,210 --> 00:27:01,950
+patient طبيعي بس هحكيلكوا شغلة الألوان مش دايما
+
+339
+00:27:01,950 --> 00:27:07,170
+بتكون صحيحة أحيانا تخدعني تمام فالأفضل القياس على
+
+340
+00:27:07,170 --> 00:27:11,390
+الجهاز مش بناء على اللون أقرر جدش ال total protein
+
+341
+00:27:11,390 --> 00:27:15,730
+مابنفع هذا الكلام بس هذه قاعدة أن شدة اللون تتناسب
+
+342
+00:27:15,730 --> 00:27:19,890
+تناسب ترضي مع تركيز ال total protein اللي موجود في
+
+343
+00:27:19,890 --> 00:27:25,190
+العينةهنا بالرسمة مش ضروري أعرف تركيبة المُركّب
+
+344
+00:27:25,190 --> 00:27:28,390
+والأحماض الأمنية لأ بس بدكوا تعرفوا إن هاي
+
+345
+00:27:28,390 --> 00:27:32,850
+كاتبلكوا peptide bond وين فيه peptide bond بيجي
+
+346
+00:27:32,850 --> 00:27:38,230
+الكبرثالفات بربط معاها و بيصير له reduction النحاس
+
+347
+00:27:38,230 --> 00:27:43,330
+و بتحول اللون من أزرج ل موف لبنفسجي بس هذا اللي
+
+348
+00:27:43,330 --> 00:27:47,570
+بدنا نعرفه من الرسمة مش مطلوب يعني منها نعرف
+
+349
+00:27:47,570 --> 00:27:53,170
+الرسمة أو نعرف تركيبة المكوناتهالجيل بدنا نحكي عن
+
+350
+00:27:53,170 --> 00:27:57,230
+الـ specimen نوع العينة يعني لو إجاني مريض وبدي
+
+351
+00:27:57,230 --> 00:28:00,750
+أفحصله الـ total protein concentration تركيز الـ
+
+352
+00:28:00,750 --> 00:28:04,930
+total protein في البلازمة تبعته العينة سيرام أو
+
+353
+00:28:04,930 --> 00:28:08,530
+بلازمة مسموح فيها سيرام and بلازمة may be used
+
+354
+00:28:08,530 --> 00:28:14,950
+تمام and all usually yield comparable resultsطبعاً
+
+355
+00:28:14,950 --> 00:28:18,650
+النتائج سواء انت سحبت بلازما من المريض أو سحبت
+
+356
+00:28:18,650 --> 00:28:23,030
+سيرم من المريض هيعطوك نفس النتائج مافي فرق يا
+
+357
+00:28:23,030 --> 00:28:29,510
+بتسحب سيرم يا بلازماطب ليش فيش فرق؟ because of the
+
+358
+00:28:29,510 --> 00:28:34,450
+presence of fibrinogen البلازما levels for total
+
+359
+00:28:34,450 --> 00:28:39,770
+iprotin are 2 ل 4 gram per liter higher than serum
+
+360
+00:28:39,770 --> 00:28:44,970
+levels إذا بدنا نتفج العينة يا سيرم يا بلازمة طيب
+
+361
+00:28:44,970 --> 00:28:49,110
+لو سألناكم سؤال شو الفرق بين السيرم و البلازمة؟الـ
+
+362
+00:28:49,110 --> 00:28:51,750
+Serum فيها بروتينات و البلازمة فيها برضه نفس
+
+363
+00:28:51,750 --> 00:28:58,630
+البروتينات بس أن البلازمة بتتميز أن فيها بروتين مش
+
+364
+00:28:58,630 --> 00:29:02,190
+موجود في الـ Serum مين هو الـ Fibrinogen إذا
+
+365
+00:29:02,190 --> 00:29:06,110
+البلازمة فيها Fibrinogenأما السيرم مافيه
+
+366
+00:29:06,110 --> 00:29:09,550
+Fibrinogen والتانين فيهم كل أنواع البروتينات بس
+
+367
+00:29:09,550 --> 00:29:14,870
+الإختلاف في الـ Fibrinogen عشان هيك بحكيلك مستوى
+
+368
+00:29:14,870 --> 00:29:19,770
+أو تركيز الـ Total Protein في البلازمة بيكون أعلى
+
+369
+00:29:19,770 --> 00:29:25,510
+من تركيز الـ Total Protein في السيرم بقيمة 2 ل 4
+
+370
+00:29:25,510 --> 00:29:32,760
+جرام per liter وهذه القيمة كتير كتير صغيرةحكينا
+
+371
+00:29:32,760 --> 00:29:36,660
+احنا تركيز لبروتينات بنقيصه بالـ gram per
+
+372
+00:29:36,660 --> 00:29:41,860
+deciliter طب هنا كتب اللي gram per liter عشان احول
+
+373
+00:29:41,860 --> 00:29:46,860
+من gram per liter ل gram per deciliter باكسم على
+
+374
+00:29:46,860 --> 00:29:51,600
+عشرة يعني اتنين تكسم عشرة واربعة تكسم عشرة ايش
+
+375
+00:29:51,600 --> 00:29:58,640
+بتطلع؟point 2 لـ point 4 gram per deciliter يعني
+
+376
+00:29:58,640 --> 00:30:05,400
+القيمة قليلة جدا جدا إذن البلازمة والسيرام العينة
+
+377
+00:30:05,400 --> 00:30:08,620
+مسموح فيها سواء بلازمة أو سيرام معلومة بيقول إن
+
+378
+00:30:08,620 --> 00:30:12,400
+الـ total protein اللي موجودة في البلازمة أعلى من
+
+379
+00:30:12,400 --> 00:30:15,620
+الـ total protein اللي موجودة في السيرام بنسبة 2 ل
+
+380
+00:30:15,620 --> 00:30:20,340
+4 gram per liter ونسبة قليلة جدا لأن البلازمة فيها
+
+381
+00:30:20,340 --> 00:30:24,810
+فيبرنوجين زود التركيزلكن الـ Serum ما فيه
+
+382
+00:30:24,810 --> 00:30:25,510
+Fibrination
+
+383
+00:30:35,130 --> 00:30:40,110
+عشان عملك فحص الـ total protein بس دايما أي فحص
+
+384
+00:30:40,110 --> 00:30:45,510
+الإنسان بده مقبل إنه يعمله الأفضل الـ desirable
+
+385
+00:30:45,510 --> 00:30:50,190
+المفضل عندنا تكون صايم okay هو مش إجباري زي فحص
+
+386
+00:30:50,190 --> 00:30:55,160
+السكر بس الأفضل إنك تكون صايم عشانالأكلات اللي انت
+
+387
+00:30:55,160 --> 00:31:00,480
+تاكله خلال اليوم ممكن يخلّي عينتك ليبمك تحسها هيك
+
+388
+00:31:00,480 --> 00:31:04,700
+لونها زي لون الحليب بيكون فيها دهون من الأكل اللي
+
+389
+00:31:04,700 --> 00:31:10,160
+انت ماكله وبنخاف يصير فيه تأثير على الفحص الـ
+
+390
+00:31:10,160 --> 00:31:14,040
+Total Protein is stable in serum and plasma هلجيت
+
+391
+00:31:14,040 --> 00:31:18,140
+عينة الـ Serum و البلازما ممكن أحفظهم تلت أيام في
+
+392
+00:31:18,140 --> 00:31:22,540
+التلاجة أو ممكن ست شهور في الـ freezer على سالب
+
+393
+00:31:22,540 --> 00:31:28,450
+عشرينالبروسيجر تبعت الفحص لما نرجع الجامعة ان شاء
+
+394
+00:31:28,450 --> 00:31:32,250
+الله هنشتغل فحص الـ Total Protein Test يا بنسحب
+
+395
+00:31:32,250 --> 00:31:36,810
+منكوا سيرام يا بنسحب منكوا بلازمة و بنشوف قداش
+
+396
+00:31:36,810 --> 00:31:39,970
+تركيز الـ Total Protein عندكوا أول شغلة بتروح
+
+397
+00:31:39,970 --> 00:31:44,040
+تجيبي تلت أنابيب بلاستيك تيوبتمام؟ بتعملي عليهم
+
+398
+00:31:44,040 --> 00:31:47,320
+label أول تيوبة بتكتب عليها blank و تاني تيوب
+
+399
+00:31:47,320 --> 00:31:51,120
+بتكتب عليها standard و تالت تيوب بتكتب عليها ال
+
+400
+00:31:51,120 --> 00:31:55,180
+patient sample اللي هو ال patient serum أو ال
+
+401
+00:31:55,180 --> 00:32:00,020
+plasma بعدين بتروح تجيب ال priority agent وعلى
+
+402
+00:32:00,020 --> 00:32:05,140
+التلت أنبيب بتحطي ألف ألف ألف microliter كل أنبوبة
+
+403
+00:32:05,140 --> 00:32:09,830
+بنحط فيها ألف من ال reagentبعدين بتروح تجيبي علبة
+
+404
+00:32:09,830 --> 00:32:13,050
+الـ Standard علبة الـ Standard بتكون يا جماعة جاية
+
+405
+00:32:13,050 --> 00:32:16,750
+مع الـ Kit هذا الـ Standard فيه مادة واحدة فقط فيه
+
+406
+00:32:16,750 --> 00:32:21,910
+لبروتينات اللي في الـ Serum تبعنا جوات الـ Totally
+
+407
+00:32:21,910 --> 00:32:26,410
+Proteins وبيكون الـ Concentration للـ Standard
+
+408
+00:32:26,410 --> 00:32:30,010
+برضه معلوم يعني تركيز الـ Totally Protein اللي
+
+409
+00:32:30,010 --> 00:32:34,530
+موجود في الـ Standard بيكون معلومكيف بقى عرفوا
+
+410
+00:32:34,530 --> 00:32:38,290
+بيكون مكتوب على علبة الـ Standard جدّاش التركيز
+
+411
+00:32:38,290 --> 00:32:42,310
+تبع الـ Standard، تمام؟ تاخد من الـ Standard 20
+
+412
+00:32:42,310 --> 00:32:47,590
+مايكرون وبتضيفيها فوق الـ 1000 مايكرون اللي موجودة
+
+413
+00:32:47,590 --> 00:32:52,090
+في تيوب الـ Standard وبتعمل ميكس منيحتيجي على الـ
+
+414
+00:32:52,090 --> 00:32:55,970
+Sample بتجيبي الـ Patient Serum أو الـ Patient
+
+415
+00:32:55,970 --> 00:33:00,850
+Plasma وبتاخدي برضه 20 مايكرون وبتحطيها على الـ
+
+416
+00:33:00,850 --> 00:33:04,790
+Reagent في انبوب الـ Sample وبتعملي Mix، تمام؟
+
+417
+00:33:05,880 --> 00:33:10,260
+تعملي mix منيح وincubation عشرة minutes at room
+
+418
+00:33:10,260 --> 00:33:14,540
+temperature تترك الأنابيب عشر دقائق على درجة حرارة
+
+419
+00:33:14,540 --> 00:33:17,480
+الغرفة بعد هيك بتروحي على جهاز لـ
+
+420
+00:33:17,480 --> 00:33:21,200
+Spectrophotometer بتثبت ال wavelength على خمسمية و
+
+421
+00:33:21,200 --> 00:33:23,840
+ستة و أربعين نانو متر طب إيش عرفني إن هذا ال
+
+422
+00:33:23,840 --> 00:33:27,240
+wavelength؟ في ال kit نفسه تبع ال total protein
+
+423
+00:33:27,240 --> 00:33:30,840
+بعطيك ورقة pamphlet هذه ال pamphlet بيكون مكتوب
+
+424
+00:33:30,840 --> 00:33:34,940
+فيها الطول الموجي اللي البروتينات بيصيرلها انتصاص
+
+425
+00:33:34,940 --> 00:33:39,270
+عليهبتصفر الجهاز على الـ Blank اللي هو عبارة عن
+
+426
+00:33:39,270 --> 00:33:43,790
+reagent فقط بعد هيك بتحط ال standard انبوبة ال
+
+427
+00:33:43,790 --> 00:33:46,150
+standard في الكيوفيت وبتقرا إيها وبتاخدي
+
+428
+00:33:46,150 --> 00:33:50,890
+absorbance لل standard وبعدين بتاخدي absorbance ل
+
+429
+00:33:50,890 --> 00:33:56,030
+ال sample وهيك بنكون خلصنا بيقولنا ال color اللون
+
+430
+00:33:56,030 --> 00:34:01,070
+ال move بيضلوا stable مدة ساعة ستين دقيقةهل جيت
+
+431
+00:34:01,070 --> 00:34:04,350
+كيف بدي أحسب تركيز الـ Total Protein؟ هيني، اشتغلت
+
+432
+00:34:04,350 --> 00:34:09,790
+الفحص بسيط جدا، عشر دقائق مدته النتيجة بتطلع عن
+
+433
+00:34:09,790 --> 00:34:14,990
+طريق تطبيق بيرزلو، قانون بيرزلو اللي هو، إيش
+
+434
+00:34:14,990 --> 00:34:18,450
+القانون بيحكي؟ أخدناه في فحص السكر الـ
+
+435
+00:34:18,450 --> 00:34:22,510
+Concentration لل patient sample يعني تركيز الـ
+
+436
+00:34:22,510 --> 00:34:26,430
+Total Protein في عينات المريض، إيش تساوي؟الـ
+
+437
+00:34:26,430 --> 00:34:32,870
+Absorbance تاعت الـ Sample على الـ Absorbance للـ
+
+438
+00:34:32,870 --> 00:34:37,570
+Standard ضرب الـ Concentration للـ Standard
+
+439
+00:34:37,570 --> 00:34:41,070
+Absorbance للـ Sample، Absorbance للـ Standard
+
+440
+00:34:41,070 --> 00:34:45,750
+وتركيز للـ Standard كله معلوم فبالطبقي بتطلعلك
+
+441
+00:34:45,750 --> 00:34:50,330
+تركيز الـ Total الـ Protein في الـ Patient Theorem
+
+442
+00:34:50,330 --> 00:34:56,570
+والوحدة بدناش ننساها Gram Per Deciliterلو كتبتلك
+
+443
+00:34:56,570 --> 00:35:01,730
+gram per liter وبدك تحوليها ل gram per deciliter
+
+444
+00:35:01,730 --> 00:35:06,030
+النتيجة بتجسميها على عشرة تمام؟
+
+445
+00:35:09,270 --> 00:35:12,650
+الـ reference range الـ normal range reference
+
+446
+00:35:12,650 --> 00:35:16,810
+range for total proteins الـ total protein في جسم
+
+447
+00:35:16,810 --> 00:35:24,450
+الإنسان 66.6 ل 81.4 gram per liter لو بدي أحولها ل
+
+448
+00:35:24,450 --> 00:35:28,490
+gram per deciliter بقى أجسم الرقم على عشرة يعني
+
+449
+00:35:28,490 --> 00:35:32,770
+حكيتلكوا الـ total protein في بلازمة دم عندنا من 6
+
+450
+00:35:32,770 --> 00:35:41,140
+.6 ل 8.1 gram per deciliterتمام؟ هنا كتبل كل واحدة
+
+451
+00:35:41,140 --> 00:35:45,080
+بالـ gram per liter results for males are
+
+452
+00:35:45,080 --> 00:35:48,820
+approximately واحد gram per liter higher than
+
+453
+00:35:48,820 --> 00:35:52,920
+results for female this difference is probably not
+
+454
+00:35:52,920 --> 00:35:56,960
+of clinical significance هنا بيحكيلي الـ total
+
+455
+00:35:56,960 --> 00:36:00,800
+protein concentrationتركيز الـ Total Protein عند
+
+456
+00:36:00,800 --> 00:36:04,420
+الرجل أعلى من تركيز الـ Total Protein عند المرأة
+
+457
+00:36:04,420 --> 00:36:10,980
+بنسبة 0.1 gram per deciliter أو 1 gram per liter
+
+458
+00:36:10,980 --> 00:36:15,400
+وهذه القيمة قليلة جدا تكاد انها تكون مهملة، تمام؟
+
+459
+00:36:16,760 --> 00:36:21,180
+معلومة بسيطة عارضة يعني إن الـ Newborns في الموليد
+
+460
+00:36:21,180 --> 00:36:26,380
+الجدد الـ mean serum بروتين concentration تركيز
+
+461
+00:36:26,380 --> 00:36:32,620
+الـ total protein عندهم 5.7 gram per deciliter
+
+462
+00:36:32,620 --> 00:36:39,820
+تمام؟أو 57 gram per liter إذا ملاحظين قليل الإنسان
+
+463
+00:36:39,820 --> 00:36:46,040
+الطبيعي بيبدأ من 6.6 أما الأطفال 5.7 يعني عندهم
+
+464
+00:36:46,040 --> 00:36:50,160
+الـ total protein قليلة لو سألناكم سؤال ليش؟ ما هو
+
+465
+00:36:50,160 --> 00:36:54,700
+بديهي المولود الجديد لسه أعضاءه ما بتكون متكاملة
+
+466
+00:36:54,700 --> 00:37:00,120
+ال liver عنده لسه مش كاملمش قادر يؤدي وظيفته عنده
+
+467
+00:37:00,120 --> 00:37:03,660
+أصلا الـ liver لسه مش مكتمل وبالتالي مش هيقدر يصنع
+
+468
+00:37:03,660 --> 00:37:07,580
+لبروتينات بالوضع الطبيعي فأكيد الـ total protein
+
+469
+00:37:07,580 --> 00:37:12,650
+عند الموليد الجدد هتكون قليل أقل من الطبيعيتبدأ
+
+470
+00:37:12,650 --> 00:37:20,370
+تزيد to 60 gram per liter بعدين تبدأ تزيد ل 6 gram
+
+471
+00:37:20,370 --> 00:37:26,070
+per deciliter خلال أول ست شهور لما يصير عمر الطفل
+
+472
+00:37:26,070 --> 00:37:32,710
+ست شهور تبدأ تزيد عنده، تمام؟وبدّه بعد ما يصير
+
+473
+00:37:32,710 --> 00:37:38,970
+عمره تلت سنين بدّه التركيز تبعه تبع الـ Total
+
+474
+00:37:38,970 --> 00:37:43,350
+Protein يكون مثل تركيز الإنسان الـ Adult الطبيعي
+
+475
+00:37:43,350 --> 00:37:49,690
+يعني بيصير 6.6 لـ 8.4 لما يصير عمره تلت سنوات خلاص
+
+476
+00:37:49,690 --> 00:37:53,770
+زي الـ Adult بيكون تركيز الـ Total Protein عنده،
+
+477
+00:37:53,770 --> 00:37:54,230
+تمام؟
+
+478
+00:37:56,930 --> 00:38:01,490
+الـ Hypo-protonemia والـ Hyper-protonemia حالات
+
+479
+00:38:01,490 --> 00:38:07,150
+مرضية لما أحكيلكم Hypo-, sorry Hypo-protonemia
+
+480
+00:38:07,150 --> 00:38:12,090
+كلمة Hypo معناها انخفاض البروتونيميا انخفاض الـ
+
+481
+00:38:12,090 --> 00:38:15,890
+total protein في بلازمة الدم يعني ماتة الـ total
+
+482
+00:38:15,890 --> 00:38:21,330
+protein بتجل تمام؟ أول شغلة في الملء الـ nutrition
+
+483
+00:38:21,330 --> 00:38:25,150
+في سوق التخزينة ماتك لأكلات فيها بروتيناتأو
+
+484
+00:38:25,150 --> 00:38:28,690
+«malabsorption» عندك سوء امتصاص يعني إنسان بياكل
+
+485
+00:38:28,690 --> 00:38:32,550
+لحمة وبقليات لكن عنده مشكلة في الأمعاء ماتمتص
+
+486
+00:38:32,550 --> 00:38:36,010
+لبروتينات وبالتالي بيصير عنده كأنه مش ماكل
+
+487
+00:38:36,010 --> 00:38:40,680
+وبالتالي بيصير عنده حالة الـhypoabrotonyالحالة
+
+488
+00:38:40,680 --> 00:38:45,140
+التانية Excessive Loss as in Renal Disease عنده
+
+489
+00:38:45,140 --> 00:38:50,160
+مشكلة في الكلة الكلة بتسرب لبروتينات مع الـUrine
+
+490
+00:38:50,160 --> 00:38:53,520
+حكينا يفترض لبروتين ماينزلش مع الـUrine يصيرله
+
+491
+00:38:53,520 --> 00:38:57,620
+إعادة امتصاص بس في حالات الـRenal Disease مشاكل في
+
+492
+00:38:57,620 --> 00:39:01,520
+الكلة بيصير عنده Excessive Loss فقد مهول
+
+493
+00:39:01,520 --> 00:39:05,560
+للبروتينات في الـUrine وبالتالي لبروتينات في الدم
+
+494
+00:39:05,560 --> 00:39:10,180
+هيجيل مستواهاG.I. Leakage هاد اختصار لـ
+
+495
+00:39:10,180 --> 00:39:15,380
+Gastrointestinal Leakage يعني بيصير عندنا تسرب من
+
+496
+00:39:15,380 --> 00:39:23,630
+الأمعاء كيف؟الأمعاء فيها مشاكل فبيصير عندي فقد الـ
+
+497
+00:39:23,630 --> 00:39:27,410
+Gastrointestinal Leakage معناها مشكلة في الأمعاء
+
+498
+00:39:27,410 --> 00:39:32,290
+وبالتالي يحدث هناك تسرب للبروتينات مع الستول يعني
+
+499
+00:39:32,290 --> 00:39:35,790
+بتخرج البروتينات مع الستول إذا كان عندك مشكلة
+
+500
+00:39:35,790 --> 00:39:39,530
+بالكلة، هتخرج مع الـUrine عندي مشكلة بالأمعاء في
+
+501
+00:39:39,530 --> 00:39:43,090
+الـGastrointestinal Tract في القناة الهضمية، هتخرج
+
+502
+00:39:43,090 --> 00:39:46,790
+البروتينات في الستول والوضع الطبيعي ممنوع أشوف
+
+503
+00:39:46,790 --> 00:39:51,370
+بروتين لا في الـUrineولا في استول Excessive
+
+504
+00:39:51,370 --> 00:39:54,650
+bleeding صار عندك نزيف لما بيصير عندك نزيف الإنسان
+
+505
+00:39:54,650 --> 00:39:58,650
+بفقد الدم فالدم أصلا فيه بروتينات وبالتالي هيجلب
+
+506
+00:39:58,650 --> 00:40:02,550
+ال severe burns الحروق اللي بتكون من الدرجة
+
+507
+00:40:02,550 --> 00:40:08,670
+التالتة يعني حروق عميقة جدا هذه الحروق بيصير في
+
+508
+00:40:08,670 --> 00:40:17,330
+عنارشح للثوائل رشح لبلازمة الدم من خلال الحرق نفسه
+
+509
+00:40:17,330 --> 00:40:22,130
+لما بيصير عندك رشح للبلازمة البلازمة بتطلع يعني
+
+510
+00:40:22,130 --> 00:40:26,010
+إيش؟ يعني البروتينات برضه بتطلع من خارج الجسم هذا
+
+511
+00:40:26,010 --> 00:40:29,670
+حرك من الدرجة التالتة برضه في الحروق بيصير عندنا
+
+512
+00:40:29,670 --> 00:40:34,010
+رشح للبروتينات عن طريق ال skin تطلع عن طريق ال
+
+513
+00:40:34,010 --> 00:40:37,470
+skin excessive catapolism يعني في عندنا الـ
+
+514
+00:40:37,470 --> 00:40:41,030
+catapolism معناه الهدمهدم وتكسير البروتينات بشكل
+
+515
+00:40:41,030 --> 00:40:45,510
+مهول مثلا البروتياز بتكون overactive عندنا
+
+516
+00:40:45,510 --> 00:40:49,930
+بروتينات اسمها بروتياز بتكسر البروتينات نشاطها
+
+517
+00:40:49,930 --> 00:40:53,950
+مهول يعني نشاطها غير عن الطبيعي وبالتالي أي بروتين
+
+518
+00:40:53,950 --> 00:40:58,050
+بتصنع بتكسره وبالتالي محصلة الـ total protein في
+
+519
+00:40:58,050 --> 00:41:01,810
+الدم هتجل liver disease عندك مشكلة في الكبد معناه
+
+520
+00:41:01,810 --> 00:41:05,740
+مش هيتم تصنيع البروتيناتأما حالات الـhyper،
+
+521
+00:41:05,740 --> 00:41:09,600
+بروتونيميا كلمة hyper معناها ارتفاع بروتونيميا
+
+522
+00:41:09,600 --> 00:41:14,480
+يعني ارتفاع الـtotal بروتين في الدم نتيجة
+
+523
+00:41:14,480 --> 00:41:19,660
+الـdehydration، نتيجة الجفاف لما إنسان يصير معاه
+
+524
+00:41:19,660 --> 00:41:25,060
+جفاففي الجفاف الإنسان يفقد سوائل صح ولا لأ
+
+525
+00:41:25,060 --> 00:41:30,000
+وبالتالي لما تفقد سوائل البروتينات الموجودة في
+
+526
+00:41:30,000 --> 00:41:34,120
+البلازمة بتتركز في جسمك تمام؟ البروتينات الموجودة
+
+527
+00:41:34,120 --> 00:41:38,180
+في البلازمة بتتركز في جسمك وبالتالي بإزداد تركيزها
+
+528
+00:41:38,880 --> 00:41:45,860
+حالات الـ Monoclonal و الـ Polyclonal هدى أمراض
+
+529
+00:41:45,860 --> 00:41:49,800
+مناعية هتاخدوها في المناعة الـ Monoclonal و الـ
+
+530
+00:41:49,800 --> 00:41:53,060
+Polyclonal معناها زيادة في الـ Antibodies ما أنتوا
+
+531
+00:41:53,060 --> 00:41:56,660
+عارفين الأجسام المضاد للـ Antibodies هي عبارة عن
+
+532
+00:41:56,660 --> 00:42:00,980
+بروتينات فلو زادت الـ Antibody معناة Total Protein
+
+533
+00:42:00,980 --> 00:42:04,800
+هيزيد، تمام؟ هدى حالات مرضية هتفهموها أكتر في
+
+534
+00:42:04,800 --> 00:42:12,680
+المناعةوالتفاجأة فقط تؤثر على تركيز الالبومين أو
+
+535
+00:42:12,680 --> 00:42:16,480
+الـ Immunoglobulins ستجعل الوضع مرتبط بقيمة
+
+536
+00:42:16,480 --> 00:42:19,900
+البروتين المتعاملة لو سألناكم سؤال بقيمة البروتين
+
+537
+00:42:19,900 --> 00:42:22,300
+المتعاملة اللي في بلازمة ده عبارة عن شو عن شقين
+
+538
+00:42:22,300 --> 00:42:27,740
+حكينا الالبومين ذات لجلوبولين واتفجنا أن الالبومين
+
+539
+00:42:29,110 --> 00:42:33,270
+يشكل نص الـ Total Protein يعني نص البروتينات
+
+540
+00:42:33,270 --> 00:42:36,310
+الموجودة في البلازمة عبارة عن ألبومين ذائد
+
+541
+00:42:36,310 --> 00:42:40,250
+Globulin الـ Globulin قلنا عبارة عن أربع أنواع
+
+542
+00:42:40,250 --> 00:42:45,630
+Alpha-1, Alpha-2 و Beta و Gamma Gamma هي الـ
+
+543
+00:42:45,630 --> 00:42:48,830
+Immunoglobulin هي الـ Antibodies الـ Gamma
+
+544
+00:42:48,830 --> 00:42:54,230
+-Globulin هي الـ Immunoglobulin الأجسام المضادةتمى
+
+545
+00:42:54,230 --> 00:42:59,590
+نحكي عنها Gamma Immunoglobulin هلجيت يا جماعة
+
+546
+00:42:59,590 --> 00:43:04,650
+بيقوللي إنه لو صار عندي مشكلة في تركيز الألبومين
+
+547
+00:43:04,650 --> 00:43:10,450
+أو صار عندي مشكلة في تركيز الـ Immunoglobulin اللي
+
+548
+00:43:10,450 --> 00:43:15,970
+هي الـ Gamma Iglobulin هدول فقط هم اللي هيأثروا
+
+549
+00:43:15,970 --> 00:43:19,930
+على تركيز الـ Total Protein ككل ليش لو سألناكم
+
+550
+00:43:19,930 --> 00:43:26,230
+سؤال؟ لأنه أصلاًتركيزهم هو الأعلى في كل البروتينات
+
+551
+00:43:26,230 --> 00:43:29,730
+يعني الـAlbumin هو تركيزه الأعلى وبيجي ورا
+
+552
+00:43:29,730 --> 00:43:35,050
+الـGamma Immunoglobulin وبالتالي أي خلل فيهم، أي
+
+553
+00:43:35,050 --> 00:43:37,430
+خلل في الـAlbumin أو في الـAntibodies في
+
+554
+00:43:37,430 --> 00:43:41,850
+الـImmunoglobulin هيأثر على كل تركيز الـTotal
+
+555
+00:43:41,850 --> 00:43:47,620
+البروتينلكن لو صار عندي مشكلة في تركيز الـ Alpha-1
+
+556
+00:43:47,620 --> 00:43:50,960
+Globulin أو الـ Alpha-2 Globulin أو الـ Beta
+
+557
+00:43:50,960 --> 00:43:57,560
+-Globulin مش هيأثروا كثير في الـ Total Protein ككل
+
+558
+00:43:57,560 --> 00:44:02,160
+مش هيأثروا في تركيز الـ Total Protein ككل وهذا
+
+559
+00:44:02,160 --> 00:44:05,620
+بيحكيليها النقطة التانية Other Ceramic Proteins
+
+560
+00:44:06,280 --> 00:44:09,280
+البروتينات الأخرى اللي موجودة في الـ Serum are
+
+561
+00:44:09,280 --> 00:44:13,900
+never imprisoned in high enough concentrations مش
+
+562
+00:44:13,900 --> 00:44:19,980
+موجودة بتركيز عالي كفاية for it changes إنه يغيرلي
+
+563
+00:44:19,980 --> 00:44:24,480
+الـ Significant Overall Effect البروتينات الأخرى
+
+564
+00:44:24,480 --> 00:44:31,140
+مش موجودة بالتركيز الكافي عشان لو حدث خلل فيها
+
+565
+00:44:31,140 --> 00:44:36,590
+يصير عندي خلل في التوطن، لأإذن من ملخص المحاضرة
+
+566
+00:44:36,590 --> 00:44:41,290
+الـ albumin أو الـ immunoglobulin حدث فيهم مشكلة
+
+567
+00:44:41,290 --> 00:44:45,730
+هيأثر على التركيز الكلي للـ total protein لكن الـ
+
+568
+00:44:45,730 --> 00:44:50,670
+α و أن الـ α2 و الـ βoglobulin لو حدث فيهم خلل هو
+
+569
+00:44:50,670 --> 00:44:53,570
+أصلا تركيزهم مش عالي كتير فلو حدث فيهم خلل مش
+
+570
+00:44:53,570 --> 00:44:57,270
+هيبين وبالتالي الـ total protein مش هيتأثر
+
+571
+00:45:00,620 --> 00:45:05,920
+Note ملاحظة مهمة to detect a small amount of a
+
+572
+00:45:05,920 --> 00:45:10,460
+protein we can use الـ TCA اختصار لـ
+
+573
+00:45:10,460 --> 00:45:15,160
+Trichloroacetic Acid أو مادة الـ Sulphosalicylic
+
+574
+00:45:15,160 --> 00:45:20,960
+Acid بتركيز 3% هلجيت يا جماعة في عينة الـ urine
+
+575
+00:45:20,960 --> 00:45:25,040
+أحياناً بتحط الـ strip و بتطلعي و بعطيك الـ strip
+
+576
+00:45:25,040 --> 00:45:32,380
+أنه مافي بروتينلكن أحيانًا ممكن تكون كمية البروتين
+
+577
+00:45:32,380 --> 00:45:36,680
+اللي موجودة في الـ urine very very small قليلة
+
+578
+00:45:36,680 --> 00:45:41,360
+جدًا وبالتالي الـ Strip ما بيقدر يكشف عنها الـ
+
+579
+00:45:41,360 --> 00:45:44,620
+Strip بيعطيك أنه مافيه بروتين بس فعليًا هو بيكون
+
+580
+00:45:44,620 --> 00:45:49,360
+فيه بروتين في الـ urine ولكن تركيزه قليل فإحنا لما
+
+581
+00:45:49,360 --> 00:45:56,030
+نشكبروح بأحط على عينة الـ urine مادة الـ TCA ممكن
+
+582
+00:45:56,030 --> 00:45:59,190
+أخدتوها ده بالسوائل أو مادة الـ sulfosalicylic
+
+583
+00:45:59,190 --> 00:46:03,390
+acid هذه مادة حنضية، إيش بتعمل لما بتحطيها على الـ
+
+584
+00:46:03,390 --> 00:46:07,970
+urine؟ لو الـ urine فيه بروتين، هذه مادة حنضية
+
+585
+00:46:07,970 --> 00:46:12,210
+هتكسر لبروتينات، هتعمل denaturation لبروتينات
+
+586
+00:46:12,730 --> 00:46:18,070
+وبالتالي هتحول عينة الـ urine لعينة معكرة، لعينة
+
+587
+00:46:18,070 --> 00:46:23,390
+تربط، فإنت لو حطتيها ولجيت العينة صارت معكرة،
+
+588
+00:46:23,390 --> 00:46:27,270
+معناه فيه بروتين جوا الـ urine، لكن لو حطيت هذه
+
+589
+00:46:27,270 --> 00:46:30,470
+المادة الحنضية على الـ urine وما صار فيه تغيير على
+
+590
+00:46:30,470 --> 00:46:35,480
+الـ urine، معناه هذا الـ urine مافيه بروتينالـ TCA
+
+591
+00:46:35,480 --> 00:46:39,520
+أو الـ Sulphosalicylic Acid مبدأ المادة البروتين
+
+592
+00:46:39,520 --> 00:46:43,260
+الـ denatured by acid لو كان فيه بروتين في اليورين
+
+593
+00:46:43,260 --> 00:46:47,920
+وضفت عليه هذا الحامض هيكسر البروتين الاسد هذا
+
+594
+00:46:47,920 --> 00:46:53,400
+هيكسر البروتين الـ precipitates هيرسبه and renders
+
+595
+00:46:53,400 --> 00:46:57,860
+the specimen more turbid ويخلي عينة اليورين معكرة
+
+596
+00:46:57,860 --> 00:47:02,820
+بالزيادة as it is concentrationincreased وهنا انت
+
+597
+00:47:02,820 --> 00:47:09,540
+تعرفي انه اكيد فيه البروتين كمان شغلة مش بس بستخدم
+
+598
+00:47:09,540 --> 00:47:12,740
+هذه الطريقة عشان اكشف عن البروتين اللي موجود
+
+599
+00:47:12,740 --> 00:47:18,330
+بكميات قليلة جدا في اليورانبطريقة الـ TCA أو الـ
+
+600
+00:47:18,330 --> 00:47:24,610
+SSA بقدر أحسب تركيز البروتين اللي موجود في عينة
+
+601
+00:47:24,610 --> 00:47:29,210
+الـ CSF الـ Cerebrospinal Fluid ثائل النخاع الشوكي
+
+602
+00:47:29,210 --> 00:47:32,970
+مش حاكينا هذا السائل فيه سكر و فيه بروتينات لكن
+
+603
+00:47:32,970 --> 00:47:37,110
+نسبة السكر جداش قليلة و نسبة البروتينات برضه قليلة
+
+604
+00:47:37,710 --> 00:47:43,130
+فلو انت جبت عينة CSF ركزوا معي وبدك تحسبي الـ
+
+605
+00:47:43,130 --> 00:47:47,090
+Total Protein اللي فيها وروحت اشتغلتي على هذه
+
+606
+00:47:47,090 --> 00:47:51,350
+العينة ضفت عليها الـ Reagent تبع الـ Pyrite
+
+607
+00:47:51,350 --> 00:47:55,310
+Reagent اللي هو الـ Reagent الأول اللي حكناه مش
+
+608
+00:47:55,310 --> 00:47:58,730
+بجيس الـ Total Protein بس كتعرفوا ان الـ Pyrite
+
+609
+00:47:58,730 --> 00:48:03,050
+Reagent بجيس الـ Total Protein اللي موجود في
+
+610
+00:48:03,050 --> 00:48:08,090
+البلازمة الدملكن ما بقدر يجيس الـ Total Protein
+
+611
+00:48:08,090 --> 00:48:12,070
+اللي موجود في الـ CSF ليش؟ خلاص، هذا الـ Reagent
+
+612
+00:48:12,070 --> 00:48:18,900
+له Linearityخطية يعني بيجيس من قيمة معينة واطلع
+
+613
+00:48:18,900 --> 00:48:24,840
+لفوق بقدرش يكشف عن كمية البروتين القليلة اللي
+
+614
+00:48:24,840 --> 00:48:29,260
+موجودة في الـ CSF إذا الـ Priority Reagent بقدرش
+
+615
+00:48:29,260 --> 00:48:33,600
+يقيس البروتينات اللي موجودة في الـ CSF لأن نسبتها
+
+616
+00:48:33,600 --> 00:48:39,940
+قليلة جدا فعمله Reagent جديدهذا الـ Reagent جواته
+
+617
+00:48:39,940 --> 00:48:46,020
+مادة الـ TCA أو مادة الـ SSA بيضفوها بيضفوله كت
+
+618
+00:48:46,020 --> 00:48:51,740
+خاص طبعاً بيضفوها على عينة الـ CSF وبيصير الـ
+
+619
+00:48:51,740 --> 00:48:55,980
+Reaction طبعاً إيش طريقتها؟ إن هذا الـ Acid هيروح
+
+620
+00:48:55,980 --> 00:49:00,700
+عينة الـ CSF يكسر البروتينات اللي فيهاويرسّب
+
+621
+00:49:00,700 --> 00:49:04,140
+لبروتينات وبالتالي انت هيك بتعملي Concentration
+
+622
+00:49:04,140 --> 00:49:08,960
+بتركزي لبروتينات عشان يقدر ال kit يقيسها اذا
+
+623
+00:49:08,960 --> 00:49:15,200
+الملخص انه ال CSF عشان اجيس ال total protein اللي
+
+624
+00:49:15,200 --> 00:49:19,840
+فيه له kit خاص ال total protein باختلف عن طريقة ال
+
+625
+00:49:19,840 --> 00:49:24,120
+«puret» method ما اسمه «puret» reagent انما ال
+
+626
+00:49:24,120 --> 00:49:27,900
+reagent المستخدم اسمه ال «TCA reagent»
+
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/p4ih5LTeu3c_raw.json b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/p4ih5LTeu3c_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..4a2c96510b9b7b179b80aaf10845f6765ceb580c
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/p4ih5LTeu3c_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 1517, "start": 1.13, "end": 15.17, "text": "السلام عليكم ورحمة الله وبركاته يعطيكم العافية جميعا اليوم ان شاء الله محاضرتنا بعنوان Pancreatic and Pancreatic Profile Test الفحوصات اللي بتشيك على وضع البنكرياس والعظام", "tokens": [6027, 3794, 37440, 25894, 24793, 4032, 2288, 35571, 3660, 21984, 4032, 26890, 4117, 9307, 3224, 37495, 9566, 1829, 24793, 18863, 31845, 10632, 10874, 2304, 40228, 995, 45595, 20498, 16472, 13412, 16606, 21984, 3714, 5016, 46958, 43500, 8315, 45030, 1863, 2407, 7649, 430, 4463, 620, 299, 293, 430, 4463, 265, 2399, 6039, 794, 9279, 27188, 5016, 2407, 9381, 9307, 13672, 1829, 39894, 8592, 1829, 4117, 15844, 4032, 11242, 3615, 29739, 1863, 4117, 16572, 32277, 16070, 3615, 19913, 10943], "avg_logprob": -0.20082131696817201, "compression_ratio": 1.521505376344086, "no_speech_prob": 7.748603820800781e-07, "words": [{"start": 1.13, "end": 1.61, "word": "السلام", "probability": 0.8771158854166666}, {"start": 1.61, "end": 2.05, "word": " عليكم", "probability": 0.948974609375}, {"start": 2.05, "end": 2.47, "word": " ورحمة", "probability": 0.9345703125}, {"start": 2.47, "end": 2.69, "word": " الله", "probability": 0.96630859375}, {"start": 2.69, "end": 3.43, "word": " وبركاته", "probability": 0.98671875}, {"start": 3.43, "end": 4.25, "word": " يعطيكم", "probability": 0.85791015625}, {"start": 4.25, "end": 4.67, "word": " العافية", "probability": 0.9449869791666666}, {"start": 4.67, "end": 5.33, "word": " جميعا", "probability": 0.9501953125}, {"start": 5.33, "end": 5.97, "word": " اليوم", "probability": 0.798095703125}, {"start": 5.97, "end": 6.09, "word": " ان", "probability": 0.646484375}, {"start": 6.09, "end": 6.29, "word": " شاء", "probability": 0.991455078125}, {"start": 6.29, "end": 6.43, "word": " الله", "probability": 0.93017578125}, {"start": 6.43, "end": 7.23, "word": " محاضرتنا", "probability": 0.94208984375}, {"start": 7.23, "end": 7.91, "word": " بعنوان", "probability": 0.944091796875}, {"start": 7.91, "end": 9.13, "word": " Pancreatic", "probability": 0.79595947265625}, {"start": 9.13, "end": 9.43, "word": " and", "probability": 0.65576171875}, {"start": 9.43, "end": 10.05, "word": " Pancreatic", "probability": 0.44219970703125}, {"start": 10.05, "end": 10.39, "word": " Profile", "probability": 0.568603515625}, {"start": 10.39, "end": 10.83, "word": " Test", "probability": 0.83154296875}, {"start": 10.83, "end": 11.87, "word": " الفحوصات", "probability": 0.88203125}, {"start": 11.87, "end": 12.01, "word": " اللي", "probability": 0.844482421875}, {"start": 12.01, "end": 12.57, "word": " بتشيك", "probability": 0.9571533203125}, {"start": 12.57, "end": 12.81, "word": " على", "probability": 0.84814453125}, {"start": 12.81, "end": 13.31, "word": " وضع", "probability": 0.9912109375}, {"start": 13.31, "end": 14.25, "word": " البنكرياس", "probability": 0.699658203125}, {"start": 14.25, "end": 15.17, "word": " والعظام", "probability": 0.854736328125}], "temperature": 1.0}, {"id": 2, "seek": 4208, "start": 16.82, "end": 42.08, "text": "نبدأ بالـ Pancreas Pancreas is a large gland عبارة عن غدة كبيرة composed of both exocrine and endocrine functions البنكرياس له وظيفتين بيشتغل كExocrine وكEndocrine نشوف وظيفته كEndocrine كEndocrine البنكرياس hormone releasing يعني بيفرز هرمونات تمام؟", "tokens": [1863, 44510, 10721, 20666, 39184, 430, 4463, 37868, 430, 4463, 37868, 307, 257, 2416, 43284, 6225, 3555, 9640, 3660, 18871, 32771, 41891, 9122, 3555, 48923, 18204, 295, 1293, 454, 3617, 533, 293, 917, 3617, 533, 6828, 29739, 1863, 4117, 16572, 32277, 46740, 4032, 19913, 33911, 2655, 9957, 4724, 1829, 8592, 2655, 17082, 1211, 9122, 11149, 3617, 533, 4032, 4117, 36952, 3617, 533, 8717, 8592, 38688, 4032, 19913, 33911, 47395, 9122, 36952, 3617, 533, 9122, 36952, 3617, 533, 29739, 1863, 4117, 16572, 32277, 24211, 16327, 37495, 22653, 4724, 33911, 2288, 11622, 8032, 2288, 2304, 2407, 8315, 2655, 46811, 10943, 22807], "avg_logprob": -0.15937499552965165, "compression_ratio": 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"compression_ratio": 1.2621359223300972, "no_speech_prob": 0.0, "words": [{"start": 253.34, "end": 253.82, "word": "هذه", "probability": 0.93701171875}, {"start": 253.82, "end": 254.34, "word": " المادة", "probability": 0.9899088541666666}, {"start": 254.34, "end": 255.36, "word": " بتساهم", "probability": 0.9022216796875}, {"start": 255.36, "end": 256.04, "word": " في", "probability": 0.94189453125}, {"start": 256.04, "end": 257.18, "word": " معادلة", "probability": 0.97412109375}, {"start": 257.18, "end": 257.8, "word": " حمود", "probability": 0.8943684895833334}, {"start": 257.8, "end": 258.76, "word": " المعيدة", "probability": 0.7119140625}, {"start": 258.76, "end": 259.08, "word": " هذه", "probability": 0.56884765625}, {"start": 259.08, "end": 259.74, "word": " أشهر", "probability": 0.981689453125}, {"start": 259.74, "end": 260.12, "word": " تلت", "probability": 0.7379557291666666}, {"start": 260.12, "end": 260.74, "word": " وظائف", "probability": 0.9833984375}, {"start": 260.74, 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"end": 275.69, "word": " glands", "probability": 0.7412109375}, {"start": 275.69, "end": 276.33, "word": " بدنا", "probability": 0.81884765625}, {"start": 276.33, "end": 276.67, "word": " نفهم", "probability": 0.9923502604166666}, {"start": 276.67, "end": 276.89, "word": " إن", "probability": 0.603515625}, {"start": 276.89, "end": 277.11, "word": " الـ", "probability": 0.825927734375}, {"start": 277.11, "end": 277.77, "word": " Amylase", "probability": 0.8912760416666666}, {"start": 277.77, "end": 278.57, "word": " موجود", "probability": 0.9892578125}, {"start": 278.57, "end": 278.83, "word": " في", "probability": 0.90576171875}, {"start": 278.83, "end": 279.31, "word": " blood", "probability": 0.49951171875}, {"start": 279.31, "end": 280.07, "word": " موجود", "probability": 0.8932291666666666}, {"start": 280.07, "end": 280.29, "word": " في", "probability": 0.9736328125}, {"start": 280.29, "end": 280.81, "word": " بلازمة", "probability": 0.6929931640625}, {"start": 280.81, "end": 281.11, "word": " دم", "probability": 0.8798828125}, {"start": 281.11, "end": 281.81, "word": " ولكن", "probability": 0.904296875}, {"start": 281.81, "end": 282.39, "word": " بـ", "probability": 0.628173828125}, {"start": 282.39, "end": 283.21, "word": " concentration", "probability": 0.6669921875}, {"start": 283.21, "end": 283.93, "word": " قليل", "probability": 0.9889322916666666}, {"start": 283.93, "end": 284.21, "word": " بـ", "probability": 0.74560546875}, {"start": 284.21, "end": 284.99, "word": " concentration", "probability": 0.8544921875}, {"start": 284.99, "end": 285.93, "word": " معين", "probability": 0.988037109375}, {"start": 285.93, "end": 286.65, "word": " لكن", "probability": 0.912109375}, {"start": 286.65, "end": 287.35, "word": " المكان", "probability": 0.989990234375}, {"start": 287.35, "end": 288.03, "word": " الأصلي", "probability": 0.7928059895833334}, {"start": 288.03, "end": 288.33, "word": " للـ", "probability": 0.940673828125}, {"start": 288.33, "end": 288.95, "word": " Amylase", "probability": 0.9138997395833334}, {"start": 288.95, "end": 289.67, "word": " موجود", "probability": 0.9833984375}, {"start": 289.67, "end": 290.07, "word": " في", "probability": 0.9931640625}, {"start": 290.07, "end": 290.35, "word": " الـ", "probability": 0.707763671875}, {"start": 290.35, "end": 291.05, "word": " pancreas", "probability": 0.9287109375}, {"start": 291.05, "end": 291.45, "word": " وفي", "probability": 0.805908203125}, {"start": 291.45, "end": 292.03, "word": " الغدد", "probability": 0.92822265625}, {"start": 292.03, "end": 293.01, "word": " اللعابية", "probability": 0.9615478515625}], "temperature": 1.0}, {"id": 14, "seek": 29380, "start": 293.22, "end": 293.8, "text": "تمام؟", "tokens": [39237, 10943, 22807], "avg_logprob": -0.1146850548684597, "compression_ratio": 0.5882352941176471, "no_speech_prob": 0.0, "words": [{"start": 293.22, "end": 293.8, "word": "تمام؟", "probability": 0.9461263020833334}], "temperature": 1.0}, {"id": 15, "seek": 32330, "start": 294.8, "end": 323.3, "text": "its function is to assist in the digestion of complex carbohydrates into simple sugars الوظيفة الأساسية لإنزايم الأميليز إنه بيتم إفرازه من الـ pancreas للأمعاء عشان يساهم ويساعد في حضم الكربوهيدرات المعقدة إلى سكريات بسيطة لأن الأمعاء ما بتقدر تمتص الكربوهيدرات المعقدة", "tokens": [1208, 2445, 307, 281, 4255, 294, 264, 40560, 295, 3997, 36817, 666, 2199, 37551, 2423, 2407, 19913, 33911, 3660, 16247, 3794, 32277, 10632, 5296, 28814, 1863, 11622, 995, 32640, 16247, 2304, 1829, 20292, 11622, 36145, 3224, 4724, 36081, 2304, 11933, 5172, 2288, 31377, 3224, 9154, 2423, 39184, 2462, 14066, 296, 24976, 10721, 2304, 3615, 16606, 6225, 8592, 7649, 7251, 3794, 995, 16095, 4032, 1829, 3794, 995, 22488, 8978, 11331, 11242, 2304, 33251, 25513, 2407, 3224, 25708, 2288, 9307, 9673, 3615, 28543, 3660, 30731, 8608, 4117, 16572, 9307, 4724, 3794, 1829, 9566, 3660, 5296, 33456, 16247, 2304, 3615, 16606, 19446, 39894, 28543, 2288, 46811, 2655, 9381, 33251, 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{"start": 299.52, "end": 300.08, "word": " carbohydrates", "probability": 0.66015625}, {"start": 300.08, "end": 301.2, "word": " into", "probability": 0.666015625}, {"start": 301.2, "end": 301.84, "word": " simple", "probability": 0.95703125}, {"start": 301.84, "end": 302.58, "word": " sugars", "probability": 0.955078125}, {"start": 302.58, "end": 303.7, "word": " الوظيفة", "probability": 0.9771484375}, {"start": 303.7, "end": 304.58, "word": " الأساسية", "probability": 0.98828125}, {"start": 304.58, "end": 305.52, "word": " لإنزايم", "probability": 0.849853515625}, {"start": 305.52, "end": 306.72, "word": " الأميليز", "probability": 0.67587890625}, {"start": 306.72, "end": 307.4, "word": " إنه", "probability": 0.6943359375}, {"start": 307.4, "end": 307.76, "word": " بيتم", "probability": 0.586669921875}, {"start": 307.76, "end": 308.3, "word": " إفرازه", "probability": 0.93603515625}, {"start": 308.3, "end": 308.48, "word": " من", "probability": 0.9970703125}, {"start": 308.48, "end": 308.72, "word": " الـ", "probability": 0.6094970703125}, {"start": 308.72, "end": 309.5, "word": " pancreas", "probability": 0.7581380208333334}, {"start": 309.5, "end": 310.76, "word": " للأمعاء", "probability": 0.87373046875}, {"start": 310.76, "end": 311.38, "word": " عشان", "probability": 0.9737955729166666}, {"start": 311.38, "end": 312.1, "word": " يساهم", "probability": 0.9937744140625}, {"start": 312.1, "end": 312.82, "word": " ويساعد", "probability": 0.97236328125}, {"start": 312.82, "end": 313.1, "word": " في", "probability": 0.98828125}, {"start": 313.1, "end": 313.98, "word": " حضم", "probability": 0.9007161458333334}, {"start": 313.98, "end": 315.44, "word": " الكربوهيدرات", "probability": 0.7314453125}, {"start": 315.44, "end": 316.58, "word": " المعقدة", "probability": 0.946533203125}, {"start": 316.58, "end": 317.12, "word": " إلى", "probability": 0.8818359375}, {"start": 317.12, "end": 318.16, "word": " سكريات", "probability": 0.9559326171875}, {"start": 318.16, "end": 318.92, "word": " بسيطة", "probability": 0.9974609375}, {"start": 318.92, "end": 319.44, "word": " لأن", "probability": 0.816650390625}, {"start": 319.44, "end": 320.04, "word": " الأمعاء", "probability": 0.916015625}, {"start": 320.04, "end": 320.24, "word": " ما", "probability": 0.57666015625}, {"start": 320.24, "end": 320.78, "word": " بتقدر", "probability": 0.9342447916666666}, {"start": 320.78, "end": 321.44, "word": " تمتص", "probability": 0.9178059895833334}, {"start": 321.44, "end": 322.58, "word": " الكربوهيدرات", "probability": 0.9710518973214286}, {"start": 322.58, "end": 323.3, "word": " المعقدة", "probability": 0.980224609375}], "temperature": 1.0}, {"id": 16, "seek": 33930, "start": 323.44, "end": 339.3, "text": "اللي يصيرلها تكسير عن طريق الـ Amylase تتكسر لجزيئات سكر صغيرة عشان يساعد هذا التكسير في عملية امتصاصها تمام؟ ميجارمنت of serum amylase", "tokens": [6027, 20292, 7251, 9381, 13546, 1211, 11296, 6055, 4117, 3794, 13546, 18871, 23032, 16572, 4587, 2423, 39184, 2012, 5088, 651, 6055, 2655, 4117, 3794, 2288, 5296, 7435, 11622, 1829, 19986, 9307, 8608, 37983, 20328, 17082, 48923, 6225, 8592, 7649, 7251, 3794, 995, 22488, 23758, 16712, 4117, 3794, 13546, 8978, 6225, 42213, 10632, 1975, 2304, 2655, 9381, 33546, 11296, 46811, 10943, 22807, 3714, 1829, 7435, 9640, 27842, 2655, 295, 32755, 669, 5088, 651], "avg_logprob": -0.18482448303536192, "compression_ratio": 1.41875, "no_speech_prob": 3.5762786865234375e-07, "words": [{"start": 323.44, "end": 323.96, "word": "اللي", "probability": 0.693115234375}, {"start": 323.96, "end": 324.66, "word": " يصيرلها", "probability": 0.87783203125}, {"start": 324.66, "end": 325.58, "word": " تكسير", "probability": 0.962890625}, {"start": 325.58, "end": 326.1, "word": " عن", "probability": 0.8740234375}, {"start": 326.1, "end": 326.58, "word": " طريق", "probability": 0.9923502604166666}, {"start": 326.58, "end": 326.8, "word": " الـ", "probability": 0.85546875}, {"start": 326.8, "end": 327.36, "word": " Amylase", "probability": 0.76171875}, {"start": 327.36, "end": 328.06, "word": " تتكسر", "probability": 0.90087890625}, {"start": 328.06, "end": 328.96, "word": " لجزيئات", "probability": 0.8965657552083334}, {"start": 328.96, "end": 329.46, "word": " سكر", "probability": 0.68359375}, {"start": 329.46, "end": 330.06, "word": " صغيرة", "probability": 0.9934895833333334}, {"start": 330.06, "end": 330.92, "word": " عشان", "probability": 0.9640299479166666}, {"start": 330.92, "end": 331.88, "word": " يساعد", "probability": 0.986328125}, {"start": 331.88, "end": 332.16, "word": " هذا", "probability": 0.85595703125}, {"start": 332.16, "end": 332.86, "word": " التكسير", "probability": 0.9945068359375}, {"start": 332.86, "end": 333.32, "word": " في", "probability": 0.916015625}, {"start": 333.32, "end": 334.0, "word": " عملية", "probability": 0.99072265625}, {"start": 334.0, "end": 335.14, "word": " امتصاصها", "probability": 0.8661295572916666}, {"start": 335.14, "end": 336.56, "word": " تمام؟", "probability": 0.7630208333333334}, {"start": 336.56, "end": 337.56, "word": " ميجارمنت", "probability": 0.655517578125}, {"start": 337.56, "end": 337.84, "word": " of", "probability": 0.414794921875}, {"start": 337.84, "end": 338.34, "word": " serum", "probability": 0.430419921875}, {"start": 338.34, "end": 339.3, "word": " amylase", "probability": 0.8483072916666666}], "temperature": 1.0}, {"id": 17, "seek": 35605, "start": 339.37, "end": 356.05, "text": "is often performed to differentiate يعني عادة فحص الأميلاز إيه بينعمل لشوه أدومي ال pain due to acute pancreatitis أحيانا ناس بنصابوا بالتهاب حاد في البنكرياز", "tokens": [271, 2049, 10332, 281, 23203, 37495, 22653, 6225, 18513, 3660, 6156, 5016, 9381, 16247, 2304, 26895, 31377, 11933, 1829, 3224, 4724, 9957, 25957, 1211, 5296, 8592, 2407, 3224, 5551, 3215, 20498, 1829, 2423, 1822, 3462, 281, 24390, 2462, 35546, 16074, 5551, 5016, 1829, 7649, 995, 8717, 32277, 44945, 9381, 16758, 14407, 4724, 6027, 2655, 11296, 3555, 11331, 18513, 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"word": " فحصت", "probability": 0.9793701171875}, {"start": 434.75, "end": 434.85, "word": " ال", "probability": 0.97021484375}, {"start": 434.85, "end": 435.45, "word": " «amylase»", "probability": 0.942578125}, {"start": 435.45, "end": 435.69, "word": " أنا", "probability": 0.83447265625}, {"start": 435.69, "end": 436.27, "word": " بعمله", "probability": 0.96240234375}, {"start": 436.27, "end": 437.03, "word": " عشان", "probability": 0.9698893229166666}, {"start": 437.03, "end": 437.87, "word": " أفرج", "probability": 0.6883951822916666}, {"start": 437.87, "end": 438.59, "word": " هل", "probability": 0.925048828125}, {"start": 438.59, "end": 439.33, "word": " وجع", "probability": 0.75048828125}, {"start": 439.33, "end": 439.93, "word": " البطن", "probability": 0.9822591145833334}, {"start": 439.93, "end": 440.23, "word": " اللي", "probability": 0.96142578125}, {"start": 440.23, "end": 440.85, "word": " بشعر", "probability": 0.89306640625}, {"start": 440.85, "end": 441.35, "word": " فيه", "probability": 0.99609375}, {"start": 441.35, "end": 442.05, "word": " المريض", "probability": 0.9775390625}, {"start": 442.05, "end": 442.83, "word": " سببه", "probability": 0.9677734375}, {"start": 442.83, "end": 443.47, "word": " التهاب", "probability": 0.9088541666666666}, {"start": 443.47, "end": 443.89, "word": " حاد", "probability": 0.834228515625}, {"start": 443.89, "end": 444.05, "word": " في", "probability": 0.8056640625}, {"start": 444.05, "end": 444.21, "word": " ال", "probability": 0.94287109375}, {"start": 444.21, "end": 445.13, "word": " «pancreas»", "probability": 0.80791015625}, {"start": 445.13, "end": 445.51, "word": " ولا", "probability": 0.6083984375}, {"start": 445.51, "end": 446.19, "word": " أسباب", "probability": 0.9861653645833334}, {"start": 446.19, "end": 446.69, "word": " أخرى", "probability": 0.9874674479166666}, {"start": 446.69, "end": 447.37, "word": " بتحتاج", "probability": 0.9449869791666666}, {"start": 447.37, "end": 447.65, "word": " إلى", "probability": 0.962890625}, {"start": 447.65, "end": 448.27, "word": " تدخل", "probability": 0.9879150390625}, {"start": 448.27, "end": 449.21, "word": " جراحي،", "probability": 0.94033203125}, {"start": 449.21, "end": 449.85, "word": " تمام؟", "probability": 0.9806315104166666}], "temperature": 1.0}, {"id": 22, "seek": 47988, "start": 451.46, "end": 479.88, "text": "الـ Isoenzymes قبل ذلك احنا حكينا ان الـ Amylase موجود في الـ Pancreas والـ Salivary gland يعني موجود بمكانين في الجسم يعني بدنا نفهم ان الـ Amylase اللي موجود في بلازمة دم تبعتنا جاي من مصدرين جاي من الـ Pancreas وجاي من الـ Salivary gland من الغدد اللي عادية اذا انزايم الـ Amylase له", "tokens": [6027, 39184, 286, 539, 268, 1229, 5814, 12174, 36150, 29910, 23275, 1975, 5016, 8315, 11331, 4117, 1829, 8315, 16472, 2423, 39184, 2012, 5088, 651, 3714, 29245, 23328, 8978, 2423, 39184, 430, 4463, 37868, 16070, 39184, 5996, 592, 822, 43284, 37495, 22653, 3714, 29245, 23328, 4724, 2304, 41361, 9957, 8978, 25724, 38251, 37495, 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{"start": 454.1, "end": 454.62, "word": " حكينا", "probability": 0.9827880859375}, {"start": 454.62, "end": 455.26, "word": " ان", "probability": 0.689453125}, {"start": 455.26, "end": 455.48, "word": " الـ", "probability": 0.656982421875}, {"start": 455.48, "end": 456.2, "word": " Amylase", "probability": 0.7367350260416666}, {"start": 456.2, "end": 457.04, "word": " موجود", "probability": 0.9728190104166666}, {"start": 457.04, "end": 457.3, "word": " في", "probability": 0.88232421875}, {"start": 457.3, "end": 457.46, "word": " الـ", "probability": 0.569580078125}, {"start": 457.46, "end": 458.12, "word": " Pancreas", "probability": 0.8131510416666666}, {"start": 458.12, "end": 458.64, "word": " والـ", "probability": 0.4764404296875}, {"start": 458.64, "end": 459.26, "word": " Salivary", "probability": 0.9449869791666666}, {"start": 459.26, "end": 459.86, "word": " gland", "probability": 0.400146484375}, {"start": 459.86, "end": 460.54, "word": " يعني", "probability": 0.8984375}, {"start": 460.54, "end": 461.16, "word": " موجود", "probability": 0.986328125}, {"start": 461.16, "end": 462.48, "word": " بمكانين", "probability": 0.88818359375}, {"start": 462.48, "end": 462.68, "word": " في", "probability": 0.97607421875}, {"start": 462.68, "end": 463.16, "word": " الجسم", "probability": 0.904296875}, {"start": 463.16, "end": 463.9, "word": " يعني", "probability": 0.94189453125}, {"start": 463.9, "end": 464.2, "word": " بدنا", "probability": 0.948486328125}, {"start": 464.2, "end": 464.66, "word": " نفهم", "probability": 0.9938151041666666}, {"start": 464.66, "end": 465.08, "word": " ان", "probability": 0.7421875}, {"start": 465.08, "end": 465.32, "word": " الـ", "probability": 0.803955078125}, {"start": 465.32, "end": 466.0, "word": " Amylase", "probability": 0.8927408854166666}, {"start": 466.0, "end": 466.38, "word": " اللي", "probability": 0.798828125}, {"start": 466.38, "end": 466.86, "word": " موجود", "probability": 0.9915364583333334}, {"start": 466.86, "end": 467.04, "word": " في", "probability": 0.900390625}, {"start": 467.04, "end": 467.7, "word": " بلازمة", "probability": 0.78076171875}, {"start": 467.7, "end": 468.08, "word": " دم", "probability": 0.786376953125}, {"start": 468.08, "end": 469.06, "word": " تبعتنا", "probability": 0.9232177734375}, {"start": 469.06, "end": 470.0, "word": " جاي", "probability": 0.90234375}, {"start": 470.0, "end": 470.18, "word": " من", "probability": 0.986328125}, {"start": 470.18, "end": 471.0, "word": " مصدرين", "probability": 0.98828125}, {"start": 471.0, "end": 471.54, "word": " جاي", "probability": 0.83837890625}, {"start": 471.54, "end": 471.72, "word": " من", "probability": 0.99560546875}, {"start": 471.72, "end": 471.96, "word": " الـ", "probability": 0.6597900390625}, {"start": 471.96, "end": 472.66, "word": " Pancreas", "probability": 0.9298502604166666}, {"start": 472.66, "end": 473.34, "word": " وجاي", "probability": 0.6310221354166666}, {"start": 473.34, "end": 473.76, "word": " من", "probability": 0.9951171875}, {"start": 473.76, "end": 473.98, "word": " الـ", "probability": 0.696044921875}, {"start": 473.98, "end": 474.64, "word": " Salivary", "probability": 0.9807942708333334}, {"start": 474.64, "end": 475.24, "word": " gland", "probability": 0.87451171875}, {"start": 475.24, "end": 475.54, "word": " من", "probability": 0.96630859375}, {"start": 475.54, "end": 476.06, "word": " الغدد", "probability": 0.908935546875}, {"start": 476.06, "end": 476.54, "word": " اللي", "probability": 0.961181640625}, {"start": 476.54, "end": 477.14, "word": " عادية", "probability": 0.89208984375}, {"start": 477.14, "end": 477.86, "word": " اذا", "probability": 0.69873046875}, {"start": 477.86, "end": 478.7, "word": " انزايم", "probability": 0.71630859375}, {"start": 478.7, "end": 478.92, "word": " الـ", "probability": 0.84423828125}, {"start": 478.92, "end": 479.5, "word": " Amylase", "probability": 0.9353841145833334}, {"start": 479.5, "end": 479.88, "word": " له", "probability": 0.57861328125}], "temperature": 1.0}, {"id": 23, "seek": 49995, "start": 480.39, "end": 499.95, "text": "نظائر تمام two iso enzymes are found in normal serum في ال serum تبعنا في عندي نظيرين لل amylase ال ISO amylase B و ال ISO amylase S سماهم P و S", "tokens": [1863, 19913, 16373, 2288, 46811, 10943, 732, 307, 78, 29299, 366, 1352, 294, 2710, 32755, 8978, 2423, 32755, 6055, 3555, 3615, 8315, 8978, 18871, 16254, 8717, 19913, 13546, 9957, 24976, 669, 5088, 651, 2423, 25042, 669, 5088, 651, 363, 4032, 2423, 25042, 669, 5088, 651, 318, 8608, 15042, 16095, 430, 4032, 318], "avg_logprob": -0.32252358715489227, "compression_ratio": 1.2986111111111112, "no_speech_prob": 3.993511199951172e-06, "words": [{"start": 480.39, "end": 481.15, "word": "نظائر", "probability": 0.8463134765625}, {"start": 481.15, "end": 481.75, "word": " تمام", "probability": 0.919677734375}, {"start": 481.75, "end": 482.93, "word": " two", "probability": 0.236328125}, {"start": 482.93, "end": 483.57, "word": " iso", "probability": 0.7119140625}, {"start": 483.57, "end": 484.09, "word": " enzymes", "probability": 0.43212890625}, {"start": 484.09, "end": 484.71, "word": " are", "probability": 0.76806640625}, {"start": 484.71, "end": 485.21, "word": " found", "probability": 0.91943359375}, {"start": 485.21, "end": 485.55, "word": " in", "probability": 0.90673828125}, {"start": 485.55, "end": 485.99, "word": " normal", "probability": 0.6171875}, {"start": 485.99, "end": 486.49, "word": " serum", "probability": 0.97802734375}, {"start": 486.49, "end": 486.95, "word": " في", "probability": 0.7900390625}, {"start": 486.95, "end": 487.19, "word": " ال", "probability": 0.572265625}, {"start": 487.19, "end": 487.55, "word": " serum", "probability": 0.39599609375}, {"start": 487.55, "end": 488.25, "word": " تبعنا", "probability": 0.8853759765625}, {"start": 488.25, "end": 488.69, "word": " في", "probability": 0.54150390625}, {"start": 488.69, "end": 489.15, "word": " عندي", "probability": 0.6566162109375}, {"start": 489.15, "end": 490.15, "word": " نظيرين", "probability": 0.9888916015625}, {"start": 490.15, "end": 490.55, "word": " لل", "probability": 0.75146484375}, {"start": 490.55, "end": 491.37, "word": " amylase", "probability": 0.6736246744791666}, {"start": 491.37, "end": 492.25, "word": " ال", "probability": 0.84765625}, {"start": 492.25, "end": 492.93, "word": " ISO", "probability": 0.53466796875}, {"start": 492.93, "end": 494.41, "word": " amylase", "probability": 0.8556315104166666}, {"start": 494.41, "end": 495.01, "word": " B", "probability": 0.49169921875}, {"start": 495.01, "end": 495.43, "word": " و", "probability": 0.51171875}, {"start": 495.43, "end": 495.57, "word": " ال", "probability": 0.3857421875}, {"start": 495.57, "end": 496.15, "word": " ISO", "probability": 0.95556640625}, {"start": 496.15, "end": 497.07, "word": " amylase", "probability": 0.9479166666666666}, {"start": 497.07, "end": 497.53, "word": " S", "probability": 0.9326171875}, {"start": 497.53, "end": 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"no_speech_prob": 0.0, "words": [{"start": 500.8, "end": 501.24, "word": "من", "probability": 0.87548828125}, {"start": 501.24, "end": 501.82, "word": " P", "probability": 0.8310546875}, {"start": 501.82, "end": 502.04, "word": " من", "probability": 0.96533203125}, {"start": 502.04, "end": 502.86, "word": " Pancreas", "probability": 0.7713216145833334}, {"start": 502.86, "end": 503.5, "word": " وS", "probability": 0.6826171875}, {"start": 503.5, "end": 503.76, "word": " من", "probability": 0.9833984375}, {"start": 503.76, "end": 504.6, "word": " Salivary", "probability": 0.9287109375}, {"start": 504.6, "end": 505.42, "word": " gland", "probability": 0.444580078125}, {"start": 505.42, "end": 506.0, "word": " إذا", "probability": 0.73291015625}, {"start": 506.0, "end": 506.34, "word": " عندنا", "probability": 0.734619140625}, {"start": 506.34, "end": 506.5, "word": " ال", "probability": 0.7451171875}, {"start": 506.5, "end": 506.98, "word": " ISO", "probability": 0.5244140625}, {"start": 506.98, "end": 507.92, "word": " Amylase", "probability": 0.7170003255208334}, {"start": 507.92, "end": 508.38, "word": " هذا", "probability": 0.4140625}, {"start": 508.38, "end": 509.08, "word": " derived", "probability": 0.69873046875}, {"start": 509.08, "end": 509.56, "word": " from", "probability": 0.71240234375}, {"start": 509.56, "end": 510.4, "word": " Pancreas", "probability": 0.8466796875}, {"start": 510.4, "end": 511.0, "word": " جاي", "probability": 0.803955078125}, {"start": 511.0, "end": 511.16, "word": " من", "probability": 0.99169921875}, {"start": 511.16, "end": 511.3, "word": " ال", "probability": 0.6669921875}, {"start": 511.3, "end": 512.04, "word": " Pancreas", "probability": 0.8683268229166666}, {"start": 512.04, "end": 512.72, "word": " ال", "probability": 0.7802734375}, {"start": 512.72, "end": 513.12, "word": " S", "probability": 0.640625}, {"start": 513.12, "end": 514.84, "word": "-Isoamylase", "probability": 0.76123046875}, {"start": 514.84, "end": 515.72, "word": " derived", "probability": 0.8740234375}, {"start": 515.72, "end": 516.46, "word": " from", "probability": 0.93017578125}, {"start": 516.46, "end": 517.62, "word": " Salivary", "probability": 0.8665364583333334}, {"start": 517.62, "end": 518.08, "word": " gland", "probability": 0.904296875}, {"start": 518.08, "end": 518.44, "word": " هذا", "probability": 0.7783203125}, {"start": 518.44, "end": 518.94, "word": " جاي", "probability": 0.923828125}, {"start": 518.94, "end": 519.24, "word": " من", "probability": 0.99658203125}, {"start": 519.24, "end": 520.06, "word": " Salivary", "probability": 0.8458658854166666}, {"start": 520.06, "end": 520.72, "word": " gland", "probability": 0.89208984375}], "temperature": 1.0}, {"id": 25, "seek": 54316, "start": 521.11, "end": 543.17, "text": "بس بدنا نفهم إن كتاتنا في المختبر بتقيس الـ Total Amylase في الدم، في بلازمة الدم، يعني بتقيس الـ Amylase تبع اللي جاي من الـ Pancreas plus الـ Amylase اللي جاي من الغدد اللعابية، ما بتقدر تحدد كل fraction على حدة", "tokens": [3555, 3794, 47525, 8315, 8717, 5172, 16095, 36145, 9122, 2655, 9307, 8315, 8978, 9673, 46456, 26890, 39894, 38436, 3794, 2423, 39184, 23170, 2012, 5088, 651, 8978, 32748, 2304, 12399, 8978, 4724, 1211, 31377, 46007, 32748, 2304, 12399, 37495, 22653, 39894, 38436, 3794, 2423, 39184, 2012, 5088, 651, 6055, 3555, 3615, 13672, 1829, 10874, 47302, 9154, 2423, 39184, 430, 4463, 37868, 1804, 2423, 39184, 2012, 5088, 651, 13672, 1829, 10874, 47302, 9154, 6024, 118, 3215, 3215, 13672, 3615, 16758, 10632, 12399, 19446, 39894, 28543, 2288, 6055, 24401, 3215, 28242, 14135, 15844, 11331, 3215, 3660], "avg_logprob": -0.1773603653654139, "compression_ratio": 1.7525773195876289, "no_speech_prob": 0.0, "words": [{"start": 521.11, "end": 521.31, "word": "بس", "probability": 0.97607421875}, {"start": 521.31, "end": 521.59, "word": " بدنا", "probability": 0.98388671875}, {"start": 521.59, "end": 522.01, "word": " نفهم", "probability": 0.9938151041666666}, {"start": 522.01, 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يجب أن يتم تجاربها بمجال التجارب", "tokens": [1211, 2655, 10721, 4117, 25708, 3714, 4587, 9640, 1863, 3660, 2423, 39184, 2462, 35546, 16074, 4724, 8592, 28820, 3714, 11242, 3615, 5172, 7251, 7435, 3555, 14739, 7251, 39237, 6055, 7435, 9640, 3555, 11296, 4724, 2304, 7435, 6027, 16712, 7435, 9640, 3555], "avg_logprob": -0.874999980131785, "compression_ratio": 1.1603773584905661, "no_speech_prob": 0.0, "words": [{"start": 710.91, "end": 712.41, "word": "لتأكيد", "probability": 0.621630859375}, {"start": 712.41, "end": 712.91, "word": " مقارنة", "probability": 0.50963134765625}, {"start": 712.91, "end": 712.91, "word": " الـ", "probability": 0.16748046875}, {"start": 712.91, "end": 714.85, "word": " pancreatitis", "probability": 0.7428385416666666}, {"start": 714.85, "end": 715.73, "word": " بشكل", "probability": 0.4232177734375}, {"start": 715.73, "end": 715.73, "word": " مضعف", "probability": 0.398712158203125}, {"start": 715.73, "end": 716.81, "word": " يجب", "probability": 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{"start": 818.61, "end": 818.87, "word": " شو", "probability": 0.894775390625}, {"start": 818.87, "end": 819.43, "word": " القصد", "probability": 0.9744466145833334}, {"start": 819.43, "end": 819.63, "word": " من", "probability": 0.9912109375}, {"start": 819.63, "end": 819.99, "word": " الجملة", "probability": 0.9700520833333334}, {"start": 819.99, "end": 820.51, "word": " الأخيرة؟", "probability": 0.9189453125}, {"start": 820.51, "end": 821.15, "word": " بيحكيلي", "probability": 0.935302734375}, {"start": 821.15, "end": 821.47, "word": " لو", "probability": 0.86474609375}], "temperature": 1.0}, {"id": 39, "seek": 84049, "start": 822.11, "end": 840.49, "text": "تركيز الـ amylase في الدم كان عالي كتير وبالتالي هيصير execution للـ amylase بكميات كبيرة عن طريق الكلة يعني في الـ urine الـ amylase هيكون عالي يعني قاعدة", "tokens": [2655, 31747, 1829, 11622, 2423, 39184, 669, 5088, 651, 8978, 32748, 2304, 25961, 6225, 6027, 1829, 9122, 2655, 13546, 46599, 6027, 2655, 6027, 1829, 39896, 9381, 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كتير", "probability": 0.8741861979166666}, {"start": 826.07, "end": 827.75, "word": " وبالتالي", "probability": 0.92666015625}, {"start": 827.75, "end": 828.79, "word": " هيصير", "probability": 0.7991536458333334}, {"start": 828.79, "end": 829.95, "word": " execution", "probability": 0.1627197265625}, {"start": 829.95, "end": 831.15, "word": " للـ", "probability": 0.686767578125}, {"start": 831.15, "end": 831.91, "word": " amylase", "probability": 0.8681640625}, {"start": 831.91, "end": 833.15, "word": " بكميات", "probability": 0.9622802734375}, {"start": 833.15, "end": 834.11, "word": " كبيرة", "probability": 0.9895833333333334}, {"start": 834.11, "end": 834.61, "word": " عن", "probability": 0.96630859375}, {"start": 834.61, "end": 835.13, "word": " طريق", "probability": 0.9920247395833334}, {"start": 835.13, "end": 835.59, "word": " الكلة", "probability": 0.5789794921875}, {"start": 835.59, "end": 836.25, "word": " يعني", "probability": 0.824951171875}, {"start": 836.25, "end": 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كمية أكبر من الـ Amylase سرلها release عن طريق الكلة وخرجت مع الـ urine يعني هيكون تركيزه في الـ urine أيضا عالي، تمام؟", "tokens": [1211, 2407, 2423, 39184, 2012, 5088, 651, 25961, 8978, 4724, 1211, 31377, 46007, 11778, 2304, 6225, 6027, 1829, 46599, 6027, 2655, 6027, 1829, 25724, 38251, 39896, 2655, 9778, 1211, 9381, 9154, 3224, 9122, 2407, 11242, 3615, 23032, 21292, 3615, 1829, 5296, 33456, 23758, 24521, 12399, 7944, 46740, 1922, 12, 9073, 20449, 9957, 3660, 25724, 38251, 39896, 2655, 9778, 1211, 9381, 9154, 3224, 18871, 23032, 16572, 4587, 33251, 37977, 6156, 28820, 19446, 25961, 2423, 39184, 2012, 5088, 651, 8978, 32748, 2304, 6225, 6027, 1829, 9122, 2655, 13546, 28242, 19446, 9122, 2304, 10632, 5551, 4117, 26890, 9154, 2423, 39184, 2012, 5088, 651, 8608, 2288, 1211, 11296, 4374, 18871, 23032, 16572, 4587, 33251, 37977, 4032, 34740, 7435, 2655, 20449, 2423, 39184, 27638, 37495, 22653, 39896, 30544, 6055, 31747, 1829, 11622, 3224, 8978, 2423, 39184, 27638, 36632, 11242, 995, 6225, 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{"start": 862.3, "end": 862.7, "word": " طريق", "probability": 0.9962565104166666}, {"start": 862.7, "end": 863.12, "word": " الكلة", "probability": 0.952392578125}, {"start": 863.12, "end": 864.22, "word": " وخرجت", "probability": 0.9732666015625}, {"start": 864.22, "end": 864.44, "word": " مع", "probability": 0.97021484375}, {"start": 864.44, "end": 864.74, "word": " الـ", "probability": 0.82568359375}, {"start": 864.74, "end": 864.94, "word": " urine", "probability": 0.783203125}, {"start": 864.94, "end": 865.28, "word": " يعني", "probability": 0.91259765625}, {"start": 865.28, "end": 865.66, "word": " هيكون", "probability": 0.88232421875}, {"start": 865.66, "end": 866.22, "word": " تركيزه", "probability": 0.9873046875}, {"start": 866.22, "end": 866.34, "word": " في", "probability": 0.98779296875}, {"start": 866.34, "end": 866.5, "word": " الـ", "probability": 0.910888671875}, {"start": 866.5, "end": 866.74, "word": " urine", "probability": 0.96630859375}, {"start": 866.74, "end": 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-0.19605654761904762, "compression_ratio": 1.4852941176470589, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 1155.41, "end": 1156.47, "word": "وبيحولها", "probability": 0.768505859375}, {"start": 1156.47, "end": 1157.75, "word": " للبارا", "probability": 0.723876953125}, {"start": 1157.75, "end": 1158.61, "word": " نيتروفينول", "probability": 0.8666178385416666}, {"start": 1158.61, "end": 1159.11, "word": " وإلى", "probability": 0.7516276041666666}, {"start": 1159.11, "end": 1159.81, "word": " جلوكوز", "probability": 0.8905436197916666}, {"start": 1159.81, "end": 1160.69, "word": " محصلة", "probability": 0.8980712890625}, {"start": 1160.69, "end": 1161.25, "word": " التفاعل", "probability": 0.9462890625}, {"start": 1161.25, "end": 1161.79, "word": " المهم", "probability": 0.986083984375}, {"start": 1161.79, "end": 1162.27, "word": " إعطاء", "probability": 0.9141845703125}, {"start": 1162.27, "end": 1162.85, "word": " مادة", "probability": 0.9384765625}, {"start": 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إن الأميلاذ بيروح على الأمعاء وبيكسر الكربوهيدرية المعقدة إلى سكريات بسيطة الليباز من اسمه من Libid الليباز بيروح على الأمعاء", "tokens": [6027, 20292, 3555, 31377, 3857, 5222, 12214, 264, 14641, 15435, 356, 17122, 295, 37421, 35386, 356, 1776, 1875, 294, 264, 42446, 6055, 5172, 26108, 8315, 36145, 16247, 2304, 26895, 45636, 4724, 13546, 2407, 5016, 15844, 16247, 2304, 3615, 16606, 4032, 21292, 4117, 3794, 2288, 33251, 25513, 2407, 3224, 25708, 2288, 10632, 9673, 3615, 28543, 3660, 30731, 8608, 4117, 16572, 9307, 4724, 3794, 1829, 9566, 3660, 13672, 1829, 3555, 31377, 9154, 24525, 2304, 3224, 9154, 15834, 327, 13672, 1829, 3555, 31377, 4724, 13546, 2407, 5016, 15844, 16247, 2304, 3615, 16606], "avg_logprob": -0.22482639054457346, "compression_ratio": 1.5666666666666667, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1202.7, "end": 1203.66, "word": "الليباز", "probability": 0.681884765625}, {"start": 1203.66, "end": 1204.98, "word": " catalyzes", "probability": 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"word": " في", "probability": 0.96337890625}, {"start": 1474.42, "end": 1475.4, "word": " البنكرياس", "probability": 0.7451171875}, {"start": 1475.4, "end": 1476.8, "word": " وجزء", "probability": 0.8811848958333334}, {"start": 1476.8, "end": 1477.46, "word": " بسيط", "probability": 0.9908447265625}, {"start": 1477.46, "end": 1477.96, "word": " جدا", "probability": 0.9931640625}, {"start": 1477.96, "end": 1478.72, "word": " منه", "probability": 0.948486328125}], "temperature": 1.0}, {"id": 71, "seek": 149196, "start": 1479.7, "end": 1491.96, "text": "من ال eye base موجود في ال small intestine وموجود أيضا في ال stomach لكن بنسب لاتوسكر فهو بشكل أساسي موجود في ال pancreas إذا هو متخصص لبنكرياس", "tokens": [27842, 2423, 3313, 3096, 3714, 29245, 23328, 8978, 2423, 1359, 42446, 4032, 2304, 29245, 23328, 36632, 11242, 995, 8978, 2423, 9665, 44381, 4724, 1863, 35457, 5296, 9307, 41779, 37983, 6156, 3224, 2407, 4724, 8592, 28820, 5551, 3794, 32277, 1829, 3714, 29245, 23328, 8978, 2423, 2462, 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{"id": 73, "seek": 155185, "start": 1523.35, "end": 1551.85, "text": "similar pattern to amylase but lasts longer يعني ارتفاعه ووصوله لل peaks عند 24 hour كله نفس الأشياء يعني بعد ما يصير عندي التهاب حاد في البنكرياس بتلت لست ساعات بيبقى ال lie base يرتفع بيصل لل peaks عند 24 hours نفس الكلام اللي حكيناه في ال amylase اللي هم نفس ال pattern", "tokens": [30937, 2202, 5102, 281, 669, 88, 875, 405, 457, 20669, 2854, 37495, 22653, 1975, 43500, 5172, 45761, 3224, 4032, 2407, 9381, 12610, 3224, 24976, 26897, 43242, 4022, 1773, 28242, 3224, 8717, 36178, 16247, 8592, 1829, 16606, 37495, 22653, 39182, 19446, 7251, 9381, 13546, 18871, 16254, 16712, 11296, 3555, 11331, 18513, 8978, 2423, 3555, 1863, 4117, 16572, 32277, 39894, 1211, 2655, 5296, 14851, 8608, 45761, 9307, 4724, 1829, 3555, 4587, 7578, 2423, 4544, 3096, 7251, 43500, 5172, 3615, 4724, 1829, 36520, 24976, 26897, 43242, 4022, 2496, 8717, 36178, 2423, 28820, 10943, 13672, 1829, 11331, 4117, 1829, 8315, 3224, 8978, 2423, 669, 88, 875, 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base", "probability": 0.6650390625}, {"start": 1543.71, "end": 1544.29, "word": " يرتفع", "probability": 0.993408203125}, {"start": 1544.29, "end": 1545.03, "word": " بيصل", "probability": 0.8701171875}, {"start": 1545.03, "end": 1545.43, "word": " لل", "probability": 0.80712890625}, {"start": 1545.43, "end": 1545.85, "word": " peaks", "probability": 0.966796875}, {"start": 1545.85, "end": 1546.39, "word": " عند", "probability": 0.970703125}, {"start": 1546.39, "end": 1546.95, "word": " 24", "probability": 0.9619140625}, {"start": 1546.95, "end": 1547.67, "word": " hours", "probability": 0.9033203125}, {"start": 1547.67, "end": 1548.21, "word": " نفس", "probability": 0.981689453125}, {"start": 1548.21, "end": 1548.67, "word": " الكلام", "probability": 0.9611002604166666}, {"start": 1548.67, "end": 1548.83, "word": " اللي", "probability": 0.970947265625}, {"start": 1548.83, "end": 1549.35, "word": " حكيناه", "probability": 0.8794921875}, {"start": 1549.35, "end": 1549.45, "word": " في", "probability": 0.96826171875}, {"start": 1549.45, "end": 1549.57, "word": " ال", "probability": 0.904296875}, {"start": 1549.57, "end": 1550.27, "word": " amylase", "probability": 0.67333984375}, {"start": 1550.27, "end": 1550.55, "word": " اللي", "probability": 0.6195068359375}, {"start": 1550.55, "end": 1550.81, "word": " هم", "probability": 0.6497802734375}, {"start": 1550.81, "end": 1551.17, "word": " نفس", "probability": 0.978759765625}, {"start": 1551.17, "end": 1551.55, "word": " ال", "probability": 0.75}, {"start": 1551.55, "end": 1551.85, "word": " pattern", "probability": 0.38623046875}], "temperature": 1.0}, {"id": 74, "seek": 157108, "start": 1553.14, "end": 1571.08, "text": "But lasts longer، لكن اللي بيميز الـ Libase عن الـ Amylase تفاجنا إن الـ Amylase بيظل عالي وبعد يومين لتلت أيام من حدوث الالتهاب الحاد في الـ pancreas بيبدأ يرجع تركيزه للوضع الطبيعي، أما الـ Libase", "tokens": [7835, 20669, 2854, 12399, 44381, 13672, 1829, 4724, 32640, 1829, 11622, 2423, 39184, 15834, 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"word": " اللي", "probability": 0.9619140625}, {"start": 1555.44, "end": 1556.0, "word": " بيميز", "probability": 0.943603515625}, {"start": 1556.0, "end": 1556.2, "word": " الـ", "probability": 0.8603515625}, {"start": 1556.2, "end": 1556.72, "word": " Libase", "probability": 0.52130126953125}, {"start": 1556.72, "end": 1557.14, "word": " عن", "probability": 0.9775390625}, {"start": 1557.14, "end": 1557.38, "word": " الـ", "probability": 0.706787109375}, {"start": 1557.38, "end": 1557.98, "word": " Amylase", "probability": 0.7837727864583334}, {"start": 1557.98, "end": 1558.76, "word": " تفاجنا", "probability": 0.767822265625}, {"start": 1558.76, "end": 1558.96, "word": " إن", "probability": 0.73046875}, {"start": 1558.96, "end": 1559.2, "word": " الـ", "probability": 0.83935546875}, {"start": 1559.2, "end": 1559.76, "word": " Amylase", "probability": 0.8876953125}, {"start": 1559.76, "end": 1560.34, "word": " بيظل", "probability": 0.7906494140625}, {"start": 1560.34, "end": 1560.94, "word": " عالي", "probability": 0.9358723958333334}, {"start": 1560.94, "end": 1561.74, "word": " وبعد", "probability": 0.684814453125}, {"start": 1561.74, "end": 1562.3, "word": " يومين", "probability": 0.96923828125}, {"start": 1562.3, "end": 1562.86, "word": " لتلت", "probability": 0.89501953125}, {"start": 1562.86, "end": 1563.32, "word": " أيام", "probability": 0.929443359375}, {"start": 1563.32, "end": 1563.5, "word": " من", "probability": 0.98779296875}, {"start": 1563.5, "end": 1564.1, "word": " حدوث", "probability": 0.979248046875}, {"start": 1564.1, "end": 1565.14, "word": " الالتهاب", "probability": 0.834765625}, {"start": 1565.14, "end": 1565.54, "word": " الحاد", "probability": 0.954833984375}, {"start": 1565.54, "end": 1565.66, "word": " في", "probability": 0.94482421875}, {"start": 1565.66, "end": 1565.82, "word": " الـ", "probability": 0.59423828125}, {"start": 1565.82, "end": 1566.4, "word": " pancreas", "probability": 0.7600911458333334}, {"start": 1566.4, "end": 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تركيزه الطبيعي", "tokens": [3555, 39184, 495, 468, 337, 10447, 1732, 1708, 37495, 22653, 4724, 1829, 11242, 1211, 14407, 6225, 6027, 1829, 8978, 32748, 2304, 16490, 2304, 3794, 36632, 10943, 39182, 11331, 3215, 2407, 12984, 2423, 6027, 2655, 11296, 3555, 39182, 16490, 2304, 3794, 36632, 10943, 4724, 13546, 7435, 3615, 30731, 6055, 31747, 1829, 11622, 3224, 41950, 21292, 3615, 1829], "avg_logprob": -0.14953399541085227, "compression_ratio": 1.348993288590604, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 1590.15, "end": 1590.83, "word": "بـresist", "probability": 0.48468017578125}, {"start": 1590.83, "end": 1591.07, "word": " for", "probability": 0.9365234375}, {"start": 1591.07, "end": 1592.07, "word": " approximately", "probability": 0.857421875}, {"start": 1592.07, "end": 1592.63, "word": " five", "probability": 0.48046875}, {"start": 1592.63, "end": 1593.07, "word": " days", "probability": 0.95751953125}, {"start": 1593.07, "end": 1593.47, "word": " يعني", 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العظم، إذا الـ Blood Cell Formation تصنيع خلايا الدم الحمرة بيصير في نخاع العظم، في عظم", "tokens": [6027, 39184, 17428, 28859, 10126, 399, 36632, 11242, 14111, 995, 4032, 19913, 33911, 3660, 29739, 11536, 4032, 9957, 39894, 2655, 9381, 1863, 3615, 16490, 15040, 25528, 32748, 2304, 21542, 2304, 25720, 22807, 8978, 29739, 11536, 3714, 2288, 4587, 12399, 8978, 8717, 9778, 45761, 18863, 19913, 2304, 12399, 11933, 15730, 2423, 39184, 17428, 28859, 10126, 399, 6055, 9381, 22653, 3615, 16490, 15040, 25528, 32748, 2304, 21542, 2304, 25720, 4724, 1829, 9381, 13546, 8978, 8717, 9778, 45761, 18863, 19913, 2304, 12399, 8978, 6225, 19913, 2304], "avg_logprob": -0.16145833422030723, "compression_ratio": 1.8159509202453987, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 2086.56, "end": 2086.82, "word": "الـ", "probability": 0.544677734375}, {"start": 2086.82, "end": 2087.06, "word": " Blood", "probability": 0.5146484375}, {"start": 2087.06, "end": 2087.32, "word": " Cell", 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enzyme الـ Alkaline Phosphatase حكينا أيضا الـ ALB يشيك على الـ liver إذا فكرين تمام؟ وأيضا بيشيك على وضع الـ Pony", "tokens": [28814, 15730, 2423, 39184, 430, 2526, 6039, 794, 9279, 5551, 16095, 27188, 5016, 2407, 9381, 9307, 13672, 1829, 39894, 8592, 1829, 4117, 15844, 4032, 11242, 3615, 2423, 39184, 430, 2526, 2423, 39184, 3511, 19324, 5296, 15042, 8717, 5016, 4117, 1829, 3511, 19324, 5296, 31377, 2304, 4032, 23557, 11296, 4724, 3794, 2288, 27884, 8717, 5016, 4117, 1829, 2423, 39184, 2623, 16378, 26867, 11933, 15730, 3511, 19324, 293, 2623, 16378, 26867, 16070, 2304, 17082, 22653, 3794, 1829, 20498, 16070, 39184, 7056, 33, 13672, 1829, 31439, 2423, 39184, 24521, 2423, 39184, 967, 19990, 533, 2623, 16378, 267, 651, 11331, 4117, 1829, 8315, 36632, 11242, 995, 2423, 39184, 7056, 33, 7251, 8592, 1829, 4117, 15844, 2423, 39184, 15019, 11933, 15730, 6156, 4117, 16572, 1863, 46811, 10943, 22807, 36725, 1829, 11242, 995, 4724, 1829, 8592, 1829, 4117, 15844, 4032, 11242, 3615, 2423, 39184, 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2134.7, "word": " الـ", "probability": 0.850341796875}, {"start": 2134.7, "end": 2135.3, "word": " Phosphorus", "probability": 0.7880859375}, {"start": 2135.3, "end": 2135.7, "word": " إذا", "probability": 0.898681640625}, {"start": 2135.7, "end": 2136.38, "word": " Calcium", "probability": 0.866943359375}, {"start": 2136.38, "end": 2136.76, "word": " and", "probability": 0.61083984375}, {"start": 2136.76, "end": 2137.48, "word": " Phosphorus", "probability": 0.9169921875}, {"start": 2137.48, "end": 2139.16, "word": " والمغنيسيوم", "probability": 0.7418387276785714}, {"start": 2139.16, "end": 2140.46, "word": " والـ", "probability": 0.5888671875}, {"start": 2140.46, "end": 2141.18, "word": " ALB", "probability": 0.8623046875}, {"start": 2141.18, "end": 2141.5, "word": " اللي", "probability": 0.96337890625}, {"start": 2141.5, "end": 2141.7, "word": " هو", "probability": 0.9921875}, {"start": 2141.7, "end": 2141.9, "word": " الـ", "probability": 0.5126953125}, {"start": 2141.9, "end": 2142.34, "word": " enzyme", "probability": 0.57763671875}, {"start": 2142.34, "end": 2142.66, "word": " الـ", "probability": 0.672607421875}, {"start": 2142.66, "end": 2143.24, "word": " Alkaline", "probability": 0.7179361979166666}, {"start": 2143.24, "end": 2144.0, "word": " Phosphatase", "probability": 0.906005859375}, {"start": 2144.0, "end": 2144.42, "word": " حكينا", "probability": 0.96826171875}, {"start": 2144.42, "end": 2144.78, "word": " أيضا", "probability": 0.9059244791666666}, {"start": 2144.78, "end": 2145.04, "word": " الـ", "probability": 0.9375}, {"start": 2145.04, "end": 2145.5, "word": " ALB", "probability": 0.948486328125}, {"start": 2145.5, "end": 2146.48, "word": " يشيك", "probability": 0.9686279296875}, {"start": 2146.48, "end": 2147.02, "word": " على", "probability": 0.9228515625}, {"start": 2147.02, "end": 2148.08, "word": " الـ", "probability": 0.634521484375}, {"start": 2148.08, "end": 2148.34, "word": " liver", "probability": 0.75927734375}, {"start": 2148.34, "end": 2148.68, "word": " إذا", "probability": 0.95751953125}, {"start": 2148.68, "end": 2149.26, "word": " فكرين", "probability": 0.7147216796875}, {"start": 2149.26, "end": 2149.84, "word": " تمام؟", "probability": 0.7605794270833334}, {"start": 2149.84, "end": 2150.36, "word": " وأيضا", "probability": 0.9033203125}, {"start": 2150.36, "end": 2151.1, "word": " بيشيك", "probability": 0.98125}, {"start": 2151.1, "end": 2151.4, "word": " على", "probability": 0.95654296875}, {"start": 2151.4, "end": 2152.06, "word": " وضع", "probability": 0.9969075520833334}, {"start": 2152.06, "end": 2152.48, "word": " الـ", "probability": 0.658447265625}, {"start": 2152.48, "end": 2152.66, "word": " Pony", "probability": 0.95068359375}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2155.06725, "duration_after_vad": 2122.898749999996}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/p4ih5LTeu3c_raw.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/p4ih5LTeu3c_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..5fb03dcfe69ed85eb0227bf8eeda7a0f15ef2a43
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/p4ih5LTeu3c_raw.srt
@@ -0,0 +1,1724 @@
+1
+00:00:01,130 --> 00:00:04,670
+السلام عليكم ورحمة الله وبركاته يعطيكم العافية
+
+2
+00:00:04,670 --> 00:00:09,130
+جميعا اليوم ان شاء الله محاضرتنا بعنوان Pancreatic
+
+3
+00:00:09,130 --> 00:00:12,570
+and Pancreatic Profile Test الفحوصات اللي بتشيك
+
+4
+00:00:12,570 --> 00:00:18,220
+على وضع البنكرياس والعظامنبدأ بالـ Pancreas
+
+5
+00:00:18,220 --> 00:00:22,580
+Pancreas is a large gland عبارة عن غدة كبيرة
+
+6
+00:00:22,580 --> 00:00:27,280
+composed of both exocrine and endocrine functions
+
+7
+00:00:27,280 --> 00:00:33,020
+البنكرياس له وظيفتين بيشتغل كExocrine وكEndocrine
+
+8
+00:00:33,020 --> 00:00:38,040
+نشوف وظيفته كEndocrine كEndocrine البنكرياس
+
+9
+00:00:38,040 --> 00:00:44,060
+hormone releasing يعني بيفرز هرمونات تمام؟إذن غدّة
+
+10
+00:00:44,060 --> 00:00:49,140
+البنكرياس تتكون من Iolic of Langerhans cell من
+
+11
+00:00:49,140 --> 00:00:54,320
+خلايا إذن في البنكرياس يوجد خلايا تسمى Iolic of
+
+12
+00:00:54,320 --> 00:00:59,120
+Langerhans cell هذه الخلايا مسؤولة عن إفراز
+
+13
+00:00:59,120 --> 00:01:04,560
+هرمونات أشهر الهرمونات أربعة Secret 4 Hormones
+
+14
+00:01:05,070 --> 00:01:08,370
+الإنسولين والـGlucagon والـGastrin
+
+15
+00:01:08,370 --> 00:01:14,470
+والـSomatoستاتين إذن هذه أربع هرمونات بتفرز من
+
+16
+00:01:14,470 --> 00:01:18,950
+خلايا البنكرياس اللي اسمها الـislet of
+
+17
+00:01:18,950 --> 00:01:25,750
+Langerhansens وهذه الهرمونات مسؤولة عن تنظيم مستوى
+
+18
+00:01:25,750 --> 00:01:30,540
+السكر في الدم، تمام؟هذه وظيفة البنكرياس كـ
+
+19
+00:01:30,540 --> 00:01:35,360
+Endocrine أما كـ Exocrine function وظيفة البنكرياس
+
+20
+00:01:35,360 --> 00:01:42,460
+إنه بيفرز إنزيمات أو ما تسمى بالعصارة البنكرياسية
+
+21
+00:01:42,460 --> 00:01:47,520
+اللي بتحتوي على إنزايم بيفرز العصارة البنكرياسية
+
+22
+00:01:47,520 --> 00:01:52,340
+على الأمعاء، تمام؟ عشان هذه العصارة هتساعد في
+
+23
+00:01:52,340 --> 00:01:57,820
+عملية هضم الأكل، هضم الطعام، تمام؟rich in
+
+24
+00:01:57,820 --> 00:02:02,820
+digestive enzyme إذن العصارة البنكرياسية اللي
+
+25
+00:02:02,820 --> 00:02:08,800
+بيفرزها البنكرياس تحتوي على إنزيمات هاضمة أشهر هذه
+
+26
+00:02:08,800 --> 00:02:14,260
+الإنزيمات الأميليز والليبيز بيفرزهم البنكرياس عشان
+
+27
+00:02:14,260 --> 00:02:19,280
+يساعدوا في هضم الطعام produced by acinar cells
+
+28
+00:02:19,280 --> 00:02:23,920
+فعنا نوع من الخلايا في البنكرياس اسمها الـacinar
+
+29
+00:02:23,920 --> 00:02:29,110
+cell تفرز الإنزيماتلكن الـ Islet of Langerhansen
+
+30
+00:02:29,110 --> 00:02:33,350
+تفرز الهرمونات تمام؟ هذه وظيفة البنكرياس
+
+31
+00:02:33,350 --> 00:02:38,970
+كIndocrine وكExocrine إذا بنظّم .. بفرز هرمونات
+
+32
+00:02:38,970 --> 00:02:43,210
+بتنظّم مستوى السكر بالدم حاجة تانية إنه بفرز
+
+33
+00:02:43,210 --> 00:02:49,850
+إنزيمات بتساعد في هضم الطعامإذن بنلخّص الـ
+
+34
+00:02:49,850 --> 00:02:54,770
+Pancreas Functions أول إشي Break down food using
+
+35
+00:02:54,770 --> 00:02:59,730
+digestive enzymes of pancreas حكينا البنكرياس بفرز
+
+36
+00:02:59,730 --> 00:03:06,600
+إنزيمات أشهرها الأميلاز والليبازوبفرز أيضًا
+
+37
+00:03:06,600 --> 00:03:10,180
+العصارة البنكرياسية بدنا نفهم إن العصارة
+
+38
+00:03:10,180 --> 00:03:13,860
+البنكرياسية تحتوي على الإنزيمات اللي بيفرزها
+
+39
+00:03:13,860 --> 00:03:17,980
+البنكرياس وتحتوي أيضًا على مواد أخرى تطلع من
+
+40
+00:03:17,980 --> 00:03:22,680
+البنكرياس تمشي في الـBiliary Duct في القناع
+
+41
+00:03:22,680 --> 00:03:27,060
+السفراوية لحد ما تصل هذه العصارة للأمعاء عشان
+
+42
+00:03:27,060 --> 00:03:32,490
+تساعد في هدم الطعام، تمام؟secretes hormone that
+
+43
+00:03:32,490 --> 00:03:36,310
+affect the level of sugar in blood حكينا إنه فيه
+
+44
+00:03:36,310 --> 00:03:42,010
+آيلة of Langerhansin جوات البنكرياز خلايا مسئولة
+
+45
+00:03:42,010 --> 00:03:46,650
+عن إفراز أربع هرمونات بتساعد كلها في تنظيم مستوى
+
+46
+00:03:46,650 --> 00:03:52,520
+السكر في الدمأيضًا الـ Pancreas بيفرز مادة
+
+47
+00:03:52,520 --> 00:03:57,300
+كيميائية produces chemicals that neutralize
+
+48
+00:03:57,300 --> 00:04:02,740
+stomach acid بيفرز مادة الـ Sodium Bicarbonate هذه
+
+49
+00:04:02,740 --> 00:04:06,360
+المادة طبيعتها، هذه المادة الكيميائية اللي بيفرزها
+
+50
+00:04:06,360 --> 00:04:12,180
+الـ Pancreas طبيعتها قاعدية، إلها alkaline pH،
+
+51
+00:04:12,180 --> 00:04:19,080
+تمام؟هذه المادة بتساهم في معادلة حمود المعيدة هذه
+
+52
+00:04:19,080 --> 00:04:25,730
+أشهر تلت وظائف للبنك الـ Yesنبدأ بأول إنزايم اللي
+
+53
+00:04:25,730 --> 00:04:30,870
+هو الـ Amylase الـ Amylase is an enzyme found
+
+54
+00:04:30,870 --> 00:04:36,330
+primarily in the pancreas and salivary glands بدنا
+
+55
+00:04:36,330 --> 00:04:40,810
+نفهم إن الـ Amylase موجود في blood موجود في بلازمة
+
+56
+00:04:40,810 --> 00:04:44,990
+دم ولكن بـ concentration قليل بـ concentration
+
+57
+00:04:44,990 --> 00:04:50,350
+معين لكن المكان الأصلي للـ Amylase موجود في الـ
+
+58
+00:04:50,350 --> 00:04:56,640
+pancreas وفي الغدد اللعابيةتمام؟its function is to
+
+59
+00:04:56,640 --> 00:05:00,080
+assist in the digestion of complex carbohydrates
+
+60
+00:05:00,080 --> 00:05:05,520
+into simple sugars الوظيفة الأساسية لإنزايم
+
+61
+00:05:05,520 --> 00:05:10,760
+الأميليز إنه بيتم إفرازه من الـ pancreas للأمعاء
+
+62
+00:05:10,760 --> 00:05:17,120
+عشان يساهم ويساعد في حضم الكربوهيدرات المعقدة إلى
+
+63
+00:05:17,120 --> 00:05:21,440
+سكريات بسيطة لأن الأمعاء ما بتقدر تمتص
+
+64
+00:05:21,440 --> 00:05:26,800
+الكربوهيدرات المعقدةاللي يصيرلها تكسير عن طريق الـ
+
+65
+00:05:26,800 --> 00:05:32,160
+Amylase تتكسر لجزيئات سكر صغيرة عشان يساعد هذا
+
+66
+00:05:32,160 --> 00:05:38,340
+التكسير في عملية امتصاصها تمام؟ ميجارمنت of serum
+
+67
+00:05:38,340 --> 00:05:42,710
+amylaseis often performed to differentiate يعني
+
+68
+00:05:42,710 --> 00:05:48,510
+عادة فحص الأميلاز إيه بينعمل لشوه أدومي ال pain
+
+69
+00:05:48,510 --> 00:05:53,470
+due to acute pancreatitis أحيانا ناس بنصابوا
+
+70
+00:05:53,470 --> 00:05:58,520
+بالتهاب حاد في البنكريازبيصير فيه التهاب شديد في
+
+71
+00:05:58,520 --> 00:06:02,360
+البنكرياس في حالات الـ Acute Pancreatitis لما
+
+72
+00:06:02,360 --> 00:06:06,280
+بيصير عندي التهاب في خلايا البنكرياس تبدأ خلايا
+
+73
+00:06:06,280 --> 00:06:11,140
+البنكرياس تعمل Release للانزيمات اللي فيها تبدأ
+
+74
+00:06:11,140 --> 00:06:16,990
+تطلع الـ Amylase من البنكرياس إلى الدموبالتالي لو
+
+75
+00:06:16,990 --> 00:06:22,370
+فحصنا لشخص عنده التهاب حاد في الـ Pancreas مستوى
+
+76
+00:06:22,370 --> 00:06:26,470
+الـ Amylase في الدم، هلاجيه عالي كتير فالـ Amylase
+
+77
+00:06:26,470 --> 00:06:32,050
+لو كان عالي، بعطيكي مؤشر إن هذا الشخص عنده التهاب
+
+78
+00:06:32,050 --> 00:06:36,730
+حاد في الخلايا الـ Pancreas وبالتالي أفرزت الـ
+
+79
+00:06:36,730 --> 00:06:40,920
+Amylase إلى الدمطبعا الناس اللي بيصير عندها التهاب
+
+80
+00:06:40,920 --> 00:06:45,180
+حاد في البنكرياس أول عرض هو abdominal pain بيصير
+
+81
+00:06:45,180 --> 00:06:50,160
+عندهم وجع في منطقة البطن from other causes of
+
+82
+00:06:50,160 --> 00:06:53,700
+abdominal pain that maybe require surgical
+
+83
+00:06:53,700 --> 00:06:58,200
+treatment يعني مش بس لما بننثاب بالتهاب حاد في
+
+84
+00:06:58,200 --> 00:07:03,000
+البنكرياس بيصير عندي وجع بطن في أسباب أخرى تعملي
+
+85
+00:07:03,000 --> 00:07:08,030
+وجع في البطنوهذه الأسباب ممكن تكون يعني مالهاش
+
+86
+00:07:08,030 --> 00:07:11,250
+علاقة في الـ pancreas وبالتالي لو فحصت ال
+
+87
+00:07:11,250 --> 00:07:15,450
+«amylase» فيها حلّجي طبيعي، إذا فحصت ال «amylase»
+
+88
+00:07:15,450 --> 00:07:21,350
+أنا بعمله عشان أفرج هل وجع البطن اللي بشعر فيه
+
+89
+00:07:21,350 --> 00:07:26,190
+المريض سببه التهاب حاد في ال «pancreas» ولا أسباب
+
+90
+00:07:26,190 --> 00:07:32,960
+أخرى بتحتاج إلى تدخل جراحي، تمام؟الـ Isoenzymes
+
+91
+00:07:32,960 --> 00:07:37,460
+قبل ذلك احنا حكينا ان الـ Amylase موجود في الـ
+
+92
+00:07:37,460 --> 00:07:42,680
+Pancreas والـ Salivary gland يعني موجود بمكانين في
+
+93
+00:07:42,680 --> 00:07:47,040
+الجسم يعني بدنا نفهم ان الـ Amylase اللي موجود في
+
+94
+00:07:47,040 --> 00:07:52,660
+بلازمة دم تبعتنا جاي من مصدرين جاي من الـ Pancreas
+
+95
+00:07:52,660 --> 00:07:57,860
+وجاي من الـ Salivary gland من الغدد اللي عادية اذا
+
+96
+00:07:57,860 --> 00:08:04,090
+انزايم الـ Amylase لهنظائر تمام two iso enzymes
+
+97
+00:08:04,090 --> 00:08:08,690
+are found in normal serum في ال serum تبعنا في
+
+98
+00:08:08,690 --> 00:08:16,150
+عندي نظيرين لل amylase ال ISO amylase B و ال ISO
+
+99
+00:08:16,150 --> 00:08:23,760
+amylase S سماهم P و Sمن P من Pancreas وS من
+
+100
+00:08:23,760 --> 00:08:28,380
+Salivary gland إذا عندنا ال ISO Amylase هذا
+
+101
+00:08:28,380 --> 00:08:33,120
+derived from Pancreas جاي من ال Pancreas ال S
+
+102
+00:08:33,120 --> 00:08:39,240
+-Isoamylase derived from Salivary gland هذا جاي من
+
+103
+00:08:39,240 --> 00:08:44,050
+Salivary glandبس بدنا نفهم إن كتاتنا في المختبر
+
+104
+00:08:44,050 --> 00:08:48,950
+بتقيس الـ Total Amylase في الدم، في بلازمة الدم،
+
+105
+00:08:48,950 --> 00:08:52,530
+يعني بتقيس الـ Amylase تبع اللي جاي من الـ
+
+106
+00:08:52,530 --> 00:08:57,070
+Pancreas plus الـ Amylase اللي جاي من الغدد
+
+107
+00:08:57,070 --> 00:09:03,840
+اللعابية، ما بتقدر تحدد كل fraction على حدةطب لو
+
+108
+00:09:03,840 --> 00:09:07,680
+بدي أعرف تركيز القميلز اللي جاي من البنكرياس لحاله
+
+109
+00:09:07,680 --> 00:09:12,020
+واللي جاي من الغدد اللعبية لحالها تلجأ إلى طرق الـ
+
+110
+00:09:12,020 --> 00:09:17,300
+Electrophoresis تفصل كل نظير على حدة وبجهاز الـ
+
+111
+00:09:17,300 --> 00:09:23,420
+densitometer وبجهاز الـ densitometer نحسب تركيز كل
+
+112
+00:09:23,420 --> 00:09:29,300
+نظير على حدة تمام؟ they are identifiedUsing
+
+113
+00:09:29,300 --> 00:09:34,920
+Electrophoresis Chromatography او Electrical
+
+114
+00:09:34,920 --> 00:09:40,760
+Focusing هذه طرق لحساب كل نظير تركيز كل نظير على
+
+115
+00:09:40,760 --> 00:09:45,680
+حدة تمام؟ و أشهرهم الـ Electrophoresis بس الفحصات
+
+116
+00:09:45,680 --> 00:09:50,320
+الكيبياية اللي هنشتغلها في المختبر فقط بتقيس الـ
+
+117
+00:09:50,320 --> 00:09:54,480
+Total Amylaseكل الـ amylase الموجود في الدم سواء
+
+118
+00:09:54,480 --> 00:09:58,120
+مصدره من الـ pancreas أو من الـ salivary gland
+
+119
+00:09:58,120 --> 00:10:06,110
+وهذه طبعاً بتقلل من تخصصية الفحثالفحص الـ total
+
+120
+00:10:06,110 --> 00:10:10,230
+amylase مش متخصص لأن لو طلعت الـ total amylase
+
+121
+00:10:10,230 --> 00:10:16,190
+عالي ما بقدر أعرف مين العالي فيهم هل الـ pancreas
+
+122
+00:10:16,190 --> 00:10:19,650
+فيه مشكلة ولا الـ salivary gland فيها مشكلة ما
+
+123
+00:10:19,650 --> 00:10:24,390
+تقدر تحدده من فحص الـ total amylase فلازم تعملي
+
+124
+00:10:24,390 --> 00:10:40,910
+Electrophoresisالسيرام Amylase يبدأ
+
+125
+00:10:40,910 --> 00:10:47,430
+بالارتفاع بعد ما يصير عندهالتهاب في البنكرياس من 3
+
+126
+00:10:47,430 --> 00:10:52,770
+إلى 6 ساعات يعني بعد ما يصير التهاب البنكرياس بـ3
+
+127
+00:10:52,770 --> 00:10:56,530
+إلى 6 ساعات بيبدأ الـamylase يطلع من خلايا
+
+128
+00:10:56,530 --> 00:11:01,030
+البنكرياس إلى الدم ويرتفع تركيزه وبيصل إلى ال
+
+129
+00:11:01,030 --> 00:11:05,590
+peaks يعني بيصل لأعلى concentration في الدم خلال
+
+130
+00:11:05,590 --> 00:11:12,400
+24 ساعة من حدوث الالتهاب الحادوبيضلوا عالي في الدم
+
+131
+00:11:12,400 --> 00:11:17,280
+The values return to normal within five days after
+
+132
+00:11:17,280 --> 00:11:23,580
+onset تقريبا بيضلوا عالي في الدم لفترة معينة وبعد
+
+133
+00:11:23,580 --> 00:11:29,520
+هيك يعني بعدمن اتنين لتلت أيام من حدوث التهاب
+
+134
+00:11:29,520 --> 00:11:35,100
+البنكرياس برجع مستوى وبرجع تركيزه طبيعي كلمة خمس
+
+135
+00:11:35,100 --> 00:11:39,920
+أيام هذه غلط فعليا من اتنين لتلت أيام يعني خلال
+
+136
+00:11:39,920 --> 00:11:44,680
+اتنين لتلت أيام من حدوث البنكرياس التهاب البنكرياس
+
+137
+00:11:44,680 --> 00:11:49,900
+بيبدأ يرجع الـamylase في الدم إلى تركيزه الطبيعي
+
+138
+00:11:50,910 --> 00:11:56,890
+لتأكيد مقارنة الـ pancreatitis بشكل مضعف يجب أن
+
+139
+00:11:56,890 --> 00:12:02,760
+يتم تجاربها بمجال التجاربعشان أأكد كفحص تأكيدي
+
+140
+00:12:02,760 --> 00:12:07,260
+لحدوث التهاب البنكرياز ما بيكفى أعمل فحص الـ
+
+141
+00:12:07,260 --> 00:12:10,920
+Amylase لوحده لأنه حكينا لو أنا فحصت الـ Total
+
+142
+00:12:10,920 --> 00:12:14,840
+Amylase وطلع عالي مش معناه عنده التهاب في
+
+143
+00:12:14,840 --> 00:12:18,580
+البنكرياز لأنه أصلا برضه الـ Amylase موجود في
+
+144
+00:12:18,580 --> 00:12:21,760
+الغدد اللعبية ممكن يكون عنده التهاب في الغدد
+
+145
+00:12:21,760 --> 00:12:28,680
+اللعبية إذا فحص مش متخصص للبنكرياز فلازم أعمل معاه
+
+146
+00:12:28,830 --> 00:12:33,350
+الـ amylase لازم أعمل معاه فحص الـ lipase الإنزايم
+
+147
+00:12:33,350 --> 00:12:36,690
+التاني الـ lipase فحص متخصص مش موجود غير في
+
+148
+00:12:36,690 --> 00:12:41,230
+البنكرياس وبالتالي لازم أعمل الفحصين مع بعض عشان
+
+149
+00:12:41,230 --> 00:12:46,510
+أؤكد حدوث التهاب البنكرياس تمام؟ the amylase
+
+150
+00:12:46,510 --> 00:12:52,440
+present in the bloodThe amylase present in the
+
+151
+00:12:52,440 --> 00:12:55,540
+blood is eliminated through the kidney and
+
+152
+00:12:55,540 --> 00:13:00,000
+excreted into the urine يعني بدنا نفهم إن الاميليز
+
+153
+00:13:00,000 --> 00:13:05,520
+عبارة عن أنزيم يعني طبيعته بروتين له half-life
+
+154
+00:13:05,520 --> 00:13:09,820
+معينة فيه بلازم الدم وبعد هيك الجسم بعمله
+
+155
+00:13:09,820 --> 00:13:15,960
+excretion بتخلص منه كيف؟ عن طريق الكلا الكلا بتعمل
+
+156
+00:13:15,960 --> 00:13:20,530
+للاميليزexecration مع الـ urine، تمام؟ يعني في الـ
+
+157
+00:13:20,530 --> 00:13:25,230
+urine ممكن نلاقي amylase بشكل طبيعي، صح ولا لأ؟
+
+158
+00:13:25,230 --> 00:13:29,930
+لأن الجسم بتخلص منه عن طريق الكدنى، therefore
+
+159
+00:13:29,930 --> 00:13:35,010
+elevation of serum activity is reflected in a rise
+
+160
+00:13:35,010 --> 00:13:39,630
+of urinary amylase activity، شو .. شو القصد من
+
+161
+00:13:39,630 --> 00:13:43,890
+الجملة الأخيرة؟ بيحكيلي لوتركيز الـ amylase في
+
+162
+00:13:43,890 --> 00:13:51,150
+الدم كان عالي كتير وبالتالي هيصير execution للـ
+
+163
+00:13:51,150 --> 00:13:56,750
+amylase بكميات كبيرة عن طريق الكلة يعني في الـ
+
+164
+00:13:56,750 --> 00:14:01,140
+urine الـ amylase هيكون عالي يعني قاعدةلو الـ
+
+165
+00:14:01,140 --> 00:14:05,620
+Amylase كان في بلازمة دم عالي وبالتالي الجسم
+
+166
+00:14:05,620 --> 00:14:10,840
+هيتخلص منه كوضع طبيعي لأن هذا enzyme، protein له
+
+167
+00:14:10,840 --> 00:14:14,760
+half-life معينة الجسم هيتخلص منه عن طريق الكلة فكل
+
+168
+00:14:14,760 --> 00:14:18,980
+ما كان الـ Amylase في الدم عالي كتير كل ما كمية
+
+169
+00:14:18,980 --> 00:14:23,120
+أكبر من الـ Amylase سرلها release عن طريق الكلة
+
+170
+00:14:23,120 --> 00:14:26,740
+وخرجت مع الـ urine يعني هيكون تركيزه في الـ urine
+
+171
+00:14:26,740 --> 00:14:28,580
+أيضا عالي، تمام؟
+
+172
+00:14:32,670 --> 00:14:38,190
+Clinical Significance يعني الأهمية الكيميائية
+
+173
+00:14:38,190 --> 00:14:43,850
+والسريرية لفحص الـ Amylase أول إشي الـ Amylase متى
+
+174
+00:14:43,850 --> 00:14:48,390
+بيزيد في حالات الـ Acute Pancreatitis أكيد التهاب
+
+175
+00:14:48,390 --> 00:14:53,650
+خلايا البنكرياس بتبدأ تفرذ الـ Amylase و تطلعه
+
+176
+00:14:53,650 --> 00:14:58,080
+للدم حالات الـ Alcoholismالناس اللي بتشرب كحول
+
+177
+00:14:58,080 --> 00:15:02,700
+كتير، الكحول بيأثر على الـPancreas وبيعمل أيضًا
+
+178
+00:15:02,700 --> 00:15:06,920
+التهاب في الـPancreas وبالتالي خلايا الـPancreas
+
+179
+00:15:06,920 --> 00:15:11,680
+هتفرز الأميلاز الـHyperlipidemia، ارتفاع الدهون
+
+180
+00:15:11,680 --> 00:15:17,870
+وخاصة للـTriglycerideهذه الدهون هتصير تتراكم على
+
+181
+00:15:17,870 --> 00:15:22,950
+الأعضاء ومن ضمنها الـ pancreas وتعمل التهاب في الـ
+
+182
+00:15:22,950 --> 00:15:28,410
+pancreas Inflammation أيضًا في الـ salivary gland
+
+183
+00:15:28,410 --> 00:15:33,470
+برضه التهاب في الغدد اللعبية ما هي أيضًا فيها الـ
+
+184
+00:15:33,470 --> 00:15:38,790
+Amylase برضه هذا هيزود تركيز الـ Amylase أن الـ
+
+185
+00:15:38,790 --> 00:15:43,630
+Amylase بقل في حالات الـ cystic fibrosisالـ
+
+186
+00:15:43,630 --> 00:15:48,910
+Principle لفحص الـ Total Amylase هو Calorimetric
+
+187
+00:15:48,910 --> 00:15:52,710
+Reaction هذا مبدأ التفاعل هذا اللي بنعرفه انه في
+
+188
+00:15:52,710 --> 00:15:57,270
+الآخر بتكون انه انه انا عندى enzyme في عينات
+
+189
+00:15:57,270 --> 00:16:01,940
+المريضفي الـ Serum عندنا الـ Amylase بدي أقيص
+
+190
+00:16:01,940 --> 00:16:07,380
+تركيزها والـ Reagent جواته Substrate جواته المادة
+
+191
+00:16:07,380 --> 00:16:11,820
+اللي بيشتغل عليها الـ enzyme لما بخلطهم على بعض ال
+
+192
+00:16:11,820 --> 00:16:16,840
+enzyme هيكسر ال substrate محصلة تكسير ال substrate
+
+193
+00:16:16,840 --> 00:16:24,750
+اعطاء مادة املونةشدة اللون تتناسب تناسب ترضي مع
+
+194
+00:16:24,750 --> 00:16:29,630
+نشاط الـ enzyme اللي موجود في عينة المريض، إذا بكل
+
+195
+00:16:29,630 --> 00:16:34,090
+بساطة سهل المبدأ، مبدأ عبارة عن colorimetric
+
+196
+00:16:34,090 --> 00:16:39,500
+reaction، نقرأ ال slideEnzymatic photometric test
+
+197
+00:16:39,500 --> 00:16:44,820
+يعني هو فحص للإنزيم وفي الآخر لون in which the
+
+198
+00:16:44,820 --> 00:16:49,060
+substrate هذه ال substrate الموجودة بال reagent مش
+
+199
+00:16:49,060 --> 00:16:57,040
+مطلوب حفظها بس مطلوب نفهم المبدأ ال EPSG7 تمام هذه
+
+200
+00:16:57,040 --> 00:17:01,300
+ال substrate موجودة في ال reagent is cleaved by
+
+201
+00:17:01,300 --> 00:17:05,780
+alpha amylases into various fragmentsالـ Alpha
+
+202
+00:17:05,780 --> 00:17:09,420
+amylases هذا الموجود هو الـ amylase اللي جاي من
+
+203
+00:17:09,420 --> 00:17:13,040
+البنكرياف ومن الـ salivary gland اللي موجود
+
+204
+00:17:13,040 --> 00:17:17,480
+already في البلازمة الدم لما بخلط الـ reagent على
+
+205
+00:17:17,480 --> 00:17:21,280
+عينة المريض الـ Alpha amylase تشتغل على هذه ال
+
+206
+00:17:21,280 --> 00:17:26,940
+substrate و بتكسرها إلى various fragments إلى أكثر
+
+207
+00:17:26,940 --> 00:17:33,710
+من قطعة إلى قطع تمام؟هؤلاء أكتر هيدروليزيه بطريقة
+
+208
+00:17:33,710 --> 00:17:39,070
+ثانية من الـ Alpha-Glucosidase تنتج جلوكوز
+
+209
+00:17:39,070 --> 00:17:45,690
+وبارانيتروفينول هذه القطع الصغيرة بيجي أنزيم آخر
+
+210
+00:17:45,960 --> 00:17:51,160
+موجود في الـReagent اثمه الـGlucosidase انزايم هذا
+
+211
+00:17:51,160 --> 00:17:55,380
+القطع الصغير هذا الانزايم يبدأ يكسر هذا القطع
+
+212
+00:17:55,380 --> 00:18:00,240
+الصغير ومحصلة التفاعل في الآخر اعطاء مادة
+
+213
+00:18:00,240 --> 00:18:07,440
+الـParametrophinol المادة الملونةاللون ويعني هل
+
+214
+00:18:07,440 --> 00:18:12,240
+اللون غانج أو فاتح هذا بتناسب تناسب ترضي مع ال
+
+215
+00:18:12,240 --> 00:18:15,720
+activity تبع ال enzyme في العينة the increase in
+
+216
+00:18:15,720 --> 00:18:21,060
+absorbance زيادة ال absorbance للعينة represents
+
+217
+00:18:21,060 --> 00:18:26,320
+بتمثل أنهالـ Total Amylase Activity in the sample
+
+218
+00:18:26,320 --> 00:18:31,840
+بتمثل نشاط كل الـ Amylase الموجودة في العينة
+
+219
+00:18:31,840 --> 00:18:38,440
+تفاجنا الـ Pancreas والـ Salivary، تمام؟ إذن، ملخص
+
+220
+00:18:38,440 --> 00:18:42,880
+الـ Principle يعني، بس بدنا نفهم المبدأ، ما بدنا
+
+221
+00:18:42,880 --> 00:18:48,440
+نحفظ أي مادة تفاجنا إن الـ EPS هذه الـ Substrate
+
+222
+00:18:48,440 --> 00:18:51,640
+اللي موجودة في الـ Reagent وبرضه الـ Reagent من
+
+223
+00:18:51,640 --> 00:18:55,620
+ضمن مكوناته الميهالـ Alpha-amylase هذا الـ amylase
+
+224
+00:18:55,620 --> 00:18:59,320
+اللي موجود في بلازمة الدم لما بنخلط عينات المريض
+
+225
+00:18:59,320 --> 00:19:02,700
+مع الـ reagent اتفجنا ان الـ amylase بيكسر ال
+
+226
+00:19:02,700 --> 00:19:07,440
+substrate لـ fragments لأكتر من قطعة بعد هيك بيجي
+
+227
+00:19:07,440 --> 00:19:11,460
+انزايم آخر اسمه الـ glucidase موجود في الـ reagent
+
+228
+00:19:11,460 --> 00:19:17,750
+بيشتغل على القطعة هذه الصغيرةوبيحولها للبارا
+
+229
+00:19:17,750 --> 00:19:22,270
+نيتروفينول وإلى جلوكوز محصلة التفاعل المهم إعطاء
+
+230
+00:19:22,270 --> 00:19:27,590
+مادة ملونة اختصار المواد ما بدنا يقعها تمام؟نبدأ
+
+231
+00:19:27,590 --> 00:19:32,390
+بالإنزايم التاني اللي بتتم إفرازه أيضًا عن طريق
+
+232
+00:19:32,390 --> 00:19:37,290
+البنكرياث الـ Libase Libase is an enzyme that
+
+233
+00:19:37,290 --> 00:19:41,630
+hydrolyses the ester linkage of fats to produce
+
+234
+00:19:41,630 --> 00:19:46,090
+alcohols and fatty acids بيحكيلي إن الـ Libase
+
+235
+00:19:46,090 --> 00:19:51,830
+عبارة عن إنزايم بيستهدف الـ ester bond يعني بقطع
+
+236
+00:19:52,100 --> 00:19:58,380
+الرابطات Easter اللي موجودة في الدهون عشان ينتج
+
+237
+00:19:58,380 --> 00:20:05,460
+الفاتي أسد والالكوهولز تمام؟الليباز catalyzes the
+
+238
+00:20:05,460 --> 00:20:10,480
+partial hydrolysis of dietary triglycerides in the
+
+239
+00:20:10,480 --> 00:20:14,180
+intestine تفاجنا إن الأميلاذ بيروح على الأمعاء
+
+240
+00:20:14,180 --> 00:20:18,700
+وبيكسر الكربوهيدرية المعقدة إلى سكريات بسيطة
+
+241
+00:20:18,700 --> 00:20:24,280
+الليباز من اسمه من Libid الليباز بيروح على الأمعاء
+
+242
+00:20:24,730 --> 00:20:30,650
+وبيكسّر الدهون الثلاثية لـ Triglyceride وبيقطّعها
+
+243
+00:20:30,650 --> 00:20:35,050
+بشكل partial يعني بيعمل Hydrolysis تكسير لها بشكل
+
+244
+00:20:35,050 --> 00:20:41,050
+جذء عشان يساعد في عملية انتصاص عشان الأمعاق تعملها
+
+245
+00:20:41,050 --> 00:20:46,190
+انتصاص بسهولة إذن بشكل أساسي بيستهدف الدهون
+
+246
+00:20:46,190 --> 00:20:52,150
+التلاتية وبيقطّعهابشكل جزءي partial hydrolysis
+
+247
+00:20:52,150 --> 00:20:57,910
+تمام Pancreatic lipase specific for fatty acid
+
+248
+00:20:57,910 --> 00:21:01,550
+residues at position one and three of the
+
+249
+00:21:01,550 --> 00:21:05,530
+triglyceride لو أنتوا فاكرين لـ Triglyceride من
+
+250
+00:21:05,530 --> 00:21:11,190
+إيش بتكونبتكون من الـ three fatty acids تلات أحماض
+
+251
+00:21:11,190 --> 00:21:16,190
+دهنية مع واحد إجليسرول مربوطين بـ Easter Bund
+
+252
+00:21:16,190 --> 00:21:22,990
+برابطة Easter صح ولا لأ؟هالجيت بيجي الـ lipase بدي
+
+253
+00:21:22,990 --> 00:21:28,270
+يفك أو بدي يفكفك الـ triglyceride بدي يقطعه بيشتغل
+
+254
+00:21:28,270 --> 00:21:32,750
+ع مين؟ بيحكي للـ lipase بيشتغل على الـ fatty acid
+
+255
+00:21:32,750 --> 00:21:37,510
+اللي موجودة على position رقم 1 والـ fatty acid
+
+256
+00:21:37,510 --> 00:21:41,550
+اللي موجودة على position رقم 3 مش حكينا الدهون
+
+257
+00:21:41,550 --> 00:21:45,290
+التلاتية عبارة عن fatty acid موجودة بموقع 1 و
+
+258
+00:21:45,290 --> 00:21:50,000
+fatty acid بموقع 2 و fatty acid بموقع رقم 3مربوطين
+
+259
+00:21:50,000 --> 00:21:54,040
+بـGlycerol بـEster Bond تمام؟ هل جيت الـ
+
+260
+00:21:54,040 --> 00:21:57,540
+Triglyceride لما .. أو sorry الـ I-base الإنزاين
+
+261
+00:21:57,540 --> 00:22:02,200
+لما بديجي يشتغل على الـ Triglyceride بيروح يقطع
+
+262
+00:22:02,200 --> 00:22:07,220
+الـ Fatty Acid اللي على رقم 1 والفاتي أسد اللي على
+
+263
+00:22:07,220 --> 00:22:12,630
+رقم 3 بيعملهم Releaseفبتضل الفاتي أسد اللي على
+
+264
+00:22:12,630 --> 00:22:18,050
+موقع رقم 2 مربوط بالـGlycerol إذا هو عمل partial
+
+265
+00:22:18,050 --> 00:22:23,370
+hydrolysis Release لفاتي أسد رقم 1 ورقم 3 أما
+
+266
+00:22:23,370 --> 00:22:28,450
+الفاتي أسد رقم 2 دلت راتب بالـGlycerol تمام؟
+
+267
+00:22:29,260 --> 00:22:33,380
+accelerated by presence of bile salt and colibase
+
+268
+00:22:33,380 --> 00:22:38,880
+شغله، شغل الـ libase بيزيد وبيكون سريع لو كان في
+
+269
+00:22:38,880 --> 00:22:41,980
+علنا الـ bile salt العصارى الصفروية أو الـ
+
+270
+00:22:41,980 --> 00:22:47,280
+cofactor يعني محفز لشغله أو الـ colibaseبدنا نشوف
+
+271
+00:22:47,280 --> 00:22:51,460
+شغل اللي بيز على لتراي غليسارايد لتراي غليسارايد
+
+272
+00:22:51,460 --> 00:22:56,360
+اللي هو اسم الآخر لتراي أسيلو غليسارول تمام؟ زي ما
+
+273
+00:22:56,360 --> 00:23:01,100
+احنا شايفين بالشكل الشكل الكيميائي بدنا شياه تمام؟
+
+274
+00:23:01,650 --> 00:23:05,890
+بس بدنا نعرف إن الـ Triglyceride الدهون التلاتية
+
+275
+00:23:05,890 --> 00:23:10,790
+من اسمها إيش تركبتها تركبتها الـ three fatty acid
+
+276
+00:23:10,790 --> 00:23:16,250
+تلت أحمد دهنية مربوطة بـ glycerol عن طريق إيستربون
+
+277
+00:23:16,250 --> 00:23:22,230
+تمام؟لما بيجي الـ Libase يشتغل على الدهون التلاتية
+
+278
+00:23:22,230 --> 00:23:28,310
+بعمل Relief لاتنين fatty acid يعني بيحرر اتنين
+
+279
+00:23:28,310 --> 00:23:33,850
+fatty acid اللي موجودين على position رقم واحد ورقم
+
+280
+00:23:33,850 --> 00:23:38,270
+تلاتة اللي ع position رقم اتنين ال fatty acid
+
+281
+00:23:38,270 --> 00:23:43,730
+بتضلها مربوطة بالجليسيرولبواسطة Easter bond إذا
+
+282
+00:23:43,730 --> 00:23:48,530
+لمّا الـ lipase يشتغل على الـ triacyl glycerol
+
+283
+00:23:48,530 --> 00:23:54,270
+بينتج عندنا اتنين mono glyceride و اتنين fatty
+
+284
+00:23:54,270 --> 00:23:57,790
+acid اتنين fatty acid سرلهم release اللي موجودين ع
+
+285
+00:23:57,790 --> 00:24:04,740
+موقع رقم واحد و تلاتة اللي ع موقع رقم اتنيناللي هي
+
+286
+00:24:04,740 --> 00:24:09,680
+فاتي أسد مربوطة بـGlycerol صار اسمها اتنين مونو
+
+287
+00:24:09,680 --> 00:24:14,480
+إجليسيرايد اتنين يعني ع position رقم اتنين مونو
+
+288
+00:24:14,480 --> 00:24:18,980
+يعني فاتي أسد واحدة إجليسيرايد دلت رابطة
+
+289
+00:24:18,980 --> 00:24:23,120
+بالـGlycerolوالفاتي acid التنتين اللي ع موقع رقم
+
+290
+00:24:23,120 --> 00:24:28,180
+واحد وتلاتة صار لهم release تمام؟ بس هذا اللي بدنا
+
+291
+00:24:28,180 --> 00:24:32,840
+نعرفه من هذه ال slide طبعا اللي بيحكيلي بشكل أساس
+
+292
+00:24:32,840 --> 00:24:40,020
+الـ lipase موجود في البنكرياس وجزء بسيط جدا منهمن
+
+293
+00:24:40,020 --> 00:24:43,500
+ال eye base موجود في ال small intestine وموجود
+
+294
+00:24:43,500 --> 00:24:48,240
+أيضا في ال stomach لكن بنسب لاتوسكر فهو بشكل أساسي
+
+295
+00:24:48,240 --> 00:24:51,960
+موجود في ال pancreas إذا هو متخصص لبنكرياس
+
+296
+00:24:53,300 --> 00:24:57,760
+Diagnostic Significance أهمية الفحص التشخيصية used
+
+297
+00:24:57,760 --> 00:25:01,800
+in diagnosis of acute pancreatitis يستخدم فحص
+
+298
+00:25:01,800 --> 00:25:06,720
+الليبز من أجل تشخيص التهاب البنكرياث الحاد
+
+299
+00:25:06,720 --> 00:25:12,800
+والتفاجنة هو فحص متخصص أكتر من الamylase ليش؟ لأن
+
+300
+00:25:12,800 --> 00:25:17,420
+الليبز بشكل أساسي بتمركز في البنكرياث كله موجود في
+
+301
+00:25:17,420 --> 00:25:21,300
+البنكرياث مش زي الamylase موجود في البنكرياث
+
+302
+00:25:21,300 --> 00:25:25,870
+والغدد اللعابيةsimilar pattern to amylase but
+
+303
+00:25:25,870 --> 00:25:34,890
+lasts longer يعني ارتفاعه ووصوله لل peaks عند 24
+
+304
+00:25:34,890 --> 00:25:39,590
+hour كله نفس الأشياء يعني بعد ما يصير عندي التهاب
+
+305
+00:25:39,590 --> 00:25:43,710
+حاد في البنكرياس بتلت لست ساعات بيبقى ال lie base
+
+306
+00:25:43,710 --> 00:25:48,830
+يرتفع بيصل لل peaks عند 24 hours نفس الكلام اللي
+
+307
+00:25:48,830 --> 00:25:53,460
+حكيناه في ال amylase اللي هم نفس ال patternBut
+
+308
+00:25:53,460 --> 00:25:57,380
+lasts longer، لكن اللي بيميز الـ Libase عن الـ
+
+309
+00:25:57,380 --> 00:26:02,300
+Amylase تفاجنا إن الـ Amylase بيظل عالي وبعد يومين
+
+310
+00:26:02,300 --> 00:26:06,400
+لتلت أيام من حدوث الالتهاب الحاد في الـ pancreas
+
+311
+00:26:06,400 --> 00:26:11,080
+بيبدأ يرجع تركيزه للوضع الطبيعي، أما الـ Libase
+
+312
+00:26:11,750 --> 00:26:17,690
+يبقى في الدم عالي لفترة أطول من الـamylase تمام؟
+
+313
+00:26:17,690 --> 00:26:22,630
+الـ libase بيحكيلي بيظل عالي و بيرجع لوضعه طبيعي
+
+314
+00:26:22,630 --> 00:26:28,390
+بعد خمس أيام من حدوث التهاب البانكرياس libase
+
+315
+00:26:28,390 --> 00:26:33,470
+elevationبـresist for approximately five days يعني
+
+316
+00:26:33,470 --> 00:26:38,570
+بيضلوا عالي في الدم خمس أيام بعد حدوث الالتهاب بعد
+
+317
+00:26:38,570 --> 00:26:45,010
+خمس أيام بيرجع إلى تركيزه الطبيعيأما الـ Amylase،
+
+318
+00:26:45,010 --> 00:26:49,850
+الـ elevations persist for only two to three days
+
+319
+00:26:49,850 --> 00:26:53,610
+يعني فقط بيضلوا عالي من يومين لتلاتة وبعد هيك
+
+320
+00:26:53,610 --> 00:26:58,910
+بيرجع إلى تركيزه الطبيعي maybe elevated in other
+
+321
+00:26:58,910 --> 00:27:03,210
+abdominal condition بحكي للـ lipase ممكن يرتفع في
+
+322
+00:27:03,210 --> 00:27:09,590
+حالات أخرى غير ال acute pancreatitis ونادرا جدا
+
+323
+00:27:09,950 --> 00:27:13,990
+تمام؟ لأنه اتفاجنا جزء بسيط منه موجود في الأنعاق
+
+324
+00:27:13,990 --> 00:27:18,550
+وموجود في المعدة فممكن يصيرله ارتفاع نتيجة
+
+325
+00:27:18,550 --> 00:27:23,460
+abdominal conditions أخرى وهذه نادرة تمام؟إذن هو
+
+326
+00:27:23,460 --> 00:27:28,980
+متخصص أكتر إشي للكشف عن مشاكل الـPancreas Normal
+
+327
+00:27:28,980 --> 00:27:33,340
+in Salivary Gland Conditions بيحكي للـLipase في
+
+328
+00:27:33,340 --> 00:27:37,660
+حالات مشاكل في حالات المشاكل اللي بتصيب الغدد
+
+329
+00:27:37,660 --> 00:27:41,480
+اللعبية الـLipase بيكون طبيعي أكيد لأنه أصلا مش
+
+330
+00:27:41,480 --> 00:27:45,940
+موجود في الغدد اللعبية أما الـAmylase في حالة
+
+331
+00:27:45,940 --> 00:27:50,440
+مشاكل في الغدد اللعبية بيرتفع لكن الـLipase بيبقى
+
+332
+00:27:50,440 --> 00:27:56,180
+Normal طبيعيLipid levels are useful in
+
+333
+00:27:56,180 --> 00:28:00,580
+differentiating serum amylase elevation as a
+
+334
+00:28:00,580 --> 00:28:05,160
+result of pancreatic versus salivary involvement
+
+335
+00:28:05,160 --> 00:28:10,880
+إيش قصده بهذه العبارة؟ كتير مهم نرجع نحكي الفحصين
+
+336
+00:28:10,880 --> 00:28:15,100
+مع بعض لازم ينعملوا ماينعملش واحد وينترك التاني
+
+337
+00:28:15,100 --> 00:28:19,610
+الأميليز والليبيذ التاني لازم ينعملواتخيلوا إنه
+
+338
+00:28:19,610 --> 00:28:24,510
+عندنا التنين والتنين طلعوا عالين، هذا Indic، هذا
+
+339
+00:28:24,510 --> 00:28:30,070
+مؤكد، يعني confirmatory test إنه أكيد هذا الشخص
+
+340
+00:28:30,070 --> 00:28:33,230
+عنده التهاب حاد في الـPancreas، لما يطلع
+
+341
+00:28:33,230 --> 00:28:38,640
+الـamylase والليبيز، التنين عالينالـ Amylase لو
+
+342
+00:28:38,640 --> 00:28:46,960
+طلع عالي والـ Lipase طلع طبيعي إذن هنا لأ أكيد مش
+
+343
+00:28:46,960 --> 00:28:51,220
+التهاب في الـPancreas لأن لو كان عن جد عنده التهاب
+
+344
+00:28:51,220 --> 00:28:54,940
+في الـPancreas كان أولا إن الـLipase هو اللي يرتفع
+
+345
+00:28:54,940 --> 00:28:59,700
+لكن طالما الـLipase طبيعي الـPancreas طبيعي، تمام؟
+
+346
+00:29:00,370 --> 00:29:05,950
+لكن لو الـ Amylase طلع عالي والـ Lipase طبيعي هذا
+
+347
+00:29:05,950 --> 00:29:10,750
+مؤكد أن المشكلة ممكن تكون Salivary gland problem
+
+348
+00:29:10,750 --> 00:29:14,510
+يعني مشاكل في الغدد اللعابية فالرتفع الـ Amylase
+
+349
+00:29:14,510 --> 00:29:18,130
+أما الـ Lipase بيظل طبيعي لو التنين كانوا عالين
+
+350
+00:29:18,130 --> 00:29:23,350
+مشاكل في الـ Pancreasالـ Amylase عالي والـ Libase
+
+351
+00:29:23,350 --> 00:29:30,470
+طبيعي مشاكل في الغدد اللعبية هذه ترجمة الجملة اللي
+
+352
+00:29:30,470 --> 00:29:36,950
+تحت تمام؟إنه الـ «Lie Base» بيستخدم عشان يفرج هل
+
+353
+00:29:36,950 --> 00:29:41,870
+ارتفاع الأميليز إله علاقة في مشاكل في البنك
+
+354
+00:29:41,870 --> 00:29:45,950
+الرياضي أم ارتفع الأميليز لإنه عندي مشكلة في
+
+355
+00:29:45,950 --> 00:29:49,870
+الغداد اللعابية، تمام؟ عشان هيك بنحكيلكوا اعملوا
+
+356
+00:29:49,870 --> 00:29:53,470
+الفحثين مع بعض عشان تحددوا وين المشكلة، غداد
+
+357
+00:29:53,470 --> 00:29:58,780
+اللعابية ولا بنك الرياضيالشيء for enzyme activity
+
+358
+00:29:58,780 --> 00:30:04,960
+بدنا طبعا هناك طرق مختلفة لقياس نشاط الإنزايم الـ
+
+359
+00:30:04,960 --> 00:30:08,220
+lipase إما colorimetric أو تربيدومتريك ال
+
+360
+00:30:08,220 --> 00:30:11,440
+colorimetric زيها زي ال amylase، ال lipase موجود
+
+361
+00:30:11,440 --> 00:30:16,320
+في السيرموبنجيب Reagent فيه Substrate بنحطه مع بعض
+
+362
+00:30:16,320 --> 00:30:19,100
+الـ lipase في الـ Serum بيشتغل على ال substrate
+
+363
+00:30:19,100 --> 00:30:23,060
+الموجودة في الـ Reagent محصلة التفاعل مادة ملونة
+
+364
+00:30:23,060 --> 00:30:28,800
+تتناسب تناسب ترضي مع نشاط الـ enzyme أما الطريقة
+
+365
+00:30:28,800 --> 00:30:32,740
+الجديدة الـ Torpedometric Methods إن الشركة
+
+366
+00:30:32,740 --> 00:30:36,560
+بتصنيعلي Reagent هذا الـ Reagent يحتوي على
+
+367
+00:30:36,560 --> 00:30:40,460
+Substrate للـ enzymeهذه الـ Substrate عبارة عن
+
+368
+00:30:40,460 --> 00:30:44,820
+Fats عبارة عن دهون الـ Reagent اللي بيكون فيه دهون
+
+369
+00:30:44,820 --> 00:30:50,460
+هذه الدهون بتعطي Turbidity للـ Reagent بتعطي عقارة
+
+370
+00:30:50,460 --> 00:30:54,920
+فالـ Reagent بيجي من الشركة جواته دهون Substrate
+
+371
+00:30:54,920 --> 00:31:00,920
+والـ Reagent طبيعته Acid تمام؟ Turbidهلجيت بنجيب
+
+372
+00:31:00,920 --> 00:31:04,540
+الـ patient sample اللي هو الـ serum اللي يحتوي
+
+373
+00:31:04,540 --> 00:31:07,840
+على الـ lipase، الـ enzyme و بخلط الـ reagent
+
+374
+00:31:07,840 --> 00:31:11,640
+المعكر مع الـ enzyme اللي موجود في عينة المريض
+
+375
+00:31:11,640 --> 00:31:15,480
+طبعاً الـ lipase اللي موجود في عينة المريض هيشتغل
+
+376
+00:31:15,480 --> 00:31:19,320
+على الـ fats اللي موجودة في الـ reagent المعكر و
+
+377
+00:31:19,320 --> 00:31:23,300
+هيكسر هذه أكيد هيكسر الدهون لأن الـ lipase بيستهدف
+
+378
+00:31:23,300 --> 00:31:29,000
+الدهون فهيكسر الدهون محصلة شغل الـ lipase على
+
+379
+00:31:29,000 --> 00:31:33,740
+الدهونبمجرد إنه اتكسّرت الدهون اللي موجودة في الـ
+
+380
+00:31:33,740 --> 00:31:38,220
+Reagent هيتحول الـ Reagent من Reagent أكر إلى
+
+381
+00:31:38,220 --> 00:31:41,740
+Reagent نظيف لأنه أصلا إيش اللي معطي العكارة للـ
+
+382
+00:31:41,740 --> 00:31:45,040
+Reagent؟ الدهون اللي موجودة فيه فإنت لما بتحط
+
+383
+00:31:45,040 --> 00:31:49,060
+Enzyme على الـ Reagent الأكر الـ Enzyme هيكسّرلك
+
+384
+00:31:49,060 --> 00:31:53,220
+ال substrate اللي هي ال fats ويتحول الـ Reagent من
+
+385
+00:31:53,220 --> 00:31:59,450
+الـ Reagent أكر إلى Reagent أكلير وبنقرأمدى
+
+386
+00:31:59,450 --> 00:32:04,370
+الـclearing يعني كده صار في عندي الـclearing لـ
+
+387
+00:32:04,370 --> 00:32:10,230
+الـ mix اللي صار هو هذا بيعبر عن الـ activity تبعت
+
+388
+00:32:10,230 --> 00:32:14,920
+الـ enzyme إذا الـ reagent تربطبسبب وجود الدهون
+
+389
+00:32:14,920 --> 00:32:19,720
+فيه بحط الـ Serum يحتوي على ليباس ليباس هيكسر
+
+390
+00:32:19,720 --> 00:32:23,340
+الدهون اللي موجودة في الـ Reagent ويحول الـ
+
+391
+00:32:23,340 --> 00:32:27,880
+Reagent من Turbid إلى Non-Turbid ونقرأ مدى الـ
+
+392
+00:32:27,880 --> 00:32:33,900
+Clearance اللي صار في الـ Reagent تمام؟خلصنا من
+
+393
+00:32:33,900 --> 00:32:37,860
+الـPancreas وبدنا نبدأ نحكي عن الـPawn، العظام
+
+394
+00:32:37,860 --> 00:32:42,280
+الـPawn is a rigid organ that constitutes part of
+
+395
+00:32:42,280 --> 00:32:46,080
+the vertebrate's skeleton بيحكيلي إن العظم عبارة
+
+396
+00:32:46,080 --> 00:32:52,820
+عن عدو صلب وبشكل أثاثي هو جزء من الهيكل العظمي
+
+397
+00:32:52,820 --> 00:32:58,450
+الفقاريالـ Function of Pons هنستعرض وظائف العظام
+
+398
+00:32:58,450 --> 00:33:04,570
+في الجسم أول إشي support تعطي الجسم و تعطي الأعضاء
+
+399
+00:33:04,570 --> 00:33:10,800
+القوام ال support تمام و الدعنةform the framework
+
+400
+00:33:10,800 --> 00:33:16,340
+that supports the body and cradles soft organs
+
+401
+00:33:16,340 --> 00:33:21,780
+العظم بيعطينا القوام تبعنا لـ framework تبع الجسم
+
+402
+00:33:21,780 --> 00:33:28,200
+احنا من غير عظم بنكون قومة لحم، تمام؟ فالعظم معطي
+
+403
+00:33:28,200 --> 00:33:32,640
+الـ framework، معطي القوام للجسم الـ protection
+
+404
+00:33:32,640 --> 00:33:37,060
+العظم اللي هو وظيفة غير ال support، إعطاء القوام،
+
+405
+00:33:37,060 --> 00:33:41,760
+الحمايةprovide a protective case for the brain
+
+406
+00:33:41,760 --> 00:33:48,380
+الدماغ محمي بالعظام الـ spinal cord الحبل الشوكي
+
+407
+00:33:48,380 --> 00:33:54,200
+محمي أيضًا بالعمود الفقري بالعظام and vital organ
+
+408
+00:33:54,200 --> 00:33:59,520
+أي عضو حي في الجسم و أي عضو مهم جدًا زي الدماغ و
+
+409
+00:33:59,520 --> 00:34:05,050
+الحبل الشوكي تلاقيهم محميين بالبعضmovement يعني من
+
+410
+00:34:05,050 --> 00:34:11,430
+خلال العظم الجسم بتحرك تمام provide liver for
+
+411
+00:34:11,430 --> 00:34:17,470
+muscle العضلات نفسها من غير ال bone مش هتتحرك مش
+
+412
+00:34:17,470 --> 00:34:22,410
+هتأدي وظيفتهاmineral storage أيضًا وظيفة الـ bone
+
+413
+00:34:22,410 --> 00:34:28,070
+إنها بتخزّن المعادن المهمة العناصر المعدنية
+
+414
+00:34:28,070 --> 00:34:33,030
+reservoir for minerals especially calcium and
+
+415
+00:34:33,030 --> 00:34:38,250
+phosphorus بشكل أساسي الكالسيوم والفوسفورس موجودين
+
+416
+00:34:38,250 --> 00:34:44,250
+جوات الـ bones مخزنين جوات العظام هذه أشهر المعادن
+
+417
+00:34:44,250 --> 00:34:48,080
+calcium and phosphorusالـ Blood Cell Formation
+
+418
+00:34:48,080 --> 00:34:53,620
+أيضًا وظيفة البون وين بتتصنع خلايا الدم الحمرة؟ في
+
+419
+00:34:53,620 --> 00:34:57,620
+البون مرق، في نخاع العظم، إذا الـ Blood Cell
+
+420
+00:34:57,620 --> 00:35:02,140
+Formation تصنيع خلايا الدم الحمرة بيصير في نخاع
+
+421
+00:35:02,140 --> 00:35:08,440
+العظم، في عظمHematopoiesis عملية التصنيع الـ red
+
+422
+00:35:08,440 --> 00:35:11,420
+blood cell production occurs within the marrow
+
+423
+00:35:11,420 --> 00:35:17,560
+cavities of bones بيصير فيه تجاويف نخاع العظم،
+
+424
+00:35:17,560 --> 00:35:24,000
+تمام؟ إذا هذه أشهر الـ function للـ bonesإذا الـ
+
+425
+00:35:24,000 --> 00:35:28,120
+Pony Profile Test أهم الفحوصات اللي بتشيك على وضع
+
+426
+00:35:28,120 --> 00:35:33,220
+الـ Pony الـ Calcium لما نحكي Calcium لازم وراها
+
+427
+00:35:33,220 --> 00:35:36,760
+بسرعة نحكي الـ Phosphorus إذا Calcium and
+
+428
+00:35:36,760 --> 00:35:42,340
+Phosphorus والمغنيسيوم والـ ALB اللي هو الـ enzyme
+
+429
+00:35:42,340 --> 00:35:46,480
+الـ Alkaline Phosphatase حكينا أيضا الـ ALB يشيك
+
+430
+00:35:46,480 --> 00:35:52,060
+على الـ liver إذا فكرين تمام؟ وأيضا بيشيك على وضع
+
+431
+00:35:52,060 --> 00:35:52,660
+الـ Pony
+
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/u4q3JwIsRVo.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/u4q3JwIsRVo.srt
new file mode 100644
index 0000000000000000000000000000000000000000..07d2cd0546a721d8a07b3bd8ff431598bb85d80a
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/u4q3JwIsRVo.srt
@@ -0,0 +1,1974 @@
+1
+00:00:00,000 --> 00:00:05,180
+بدنا نحكي عن ال bone profile test، الفحصّات اللي
+
+2
+00:00:05,180 --> 00:00:11,260
+بتشيك على وضع العظام. أول فحص هو الـ calcium.
+
+3
+00:00:11,260 --> 00:00:16,760
+Calcium is required for cell function overall and for bone
+
+4
+00:00:16,760 --> 00:00:21,720
+metabolism. Approximately 99% of body calcium is
+
+5
+00:00:21,720 --> 00:00:28,720
+found in bones. بيحكيلي إنه الـ calcium مهم جدا لكل
+
+6
+00:00:28,720 --> 00:00:35,720
+الخلايا عشان تؤدي وظائفها، وأيضا مهم لبناء العظم.
+
+7
+00:00:35,720 --> 00:00:42,060
+أصلا حكينا إن العظم هو المخزن تبع الـ calcium. تمام؟
+
+8
+00:00:42,060 --> 00:00:47,980
+فالـكالسيوم هو المسؤول عن إعطاء الـ rigidity للعظم.
+
+9
+00:00:47,980 --> 00:00:52,580
+ليش العظام حكينا rigid، صلبة؟ من الأعطاها الصلابة؟
+
+10
+00:00:52,580 --> 00:00:58,980
+هذه وجود الكالسيوم فيها. Approximately 99% من الـ
+
+11
+00:00:58,980 --> 00:01:02,940
+body calcium is found in bones. يعني 99% من
+
+12
+00:01:02,940 --> 00:01:08,440
+الكالسيوم اللي موجود جوات الجسم مخزن داخل العظام.
+
+13
+00:01:08,440 --> 00:01:15,040
+1% فقط هو اللي موجود في بلازما الدم،
+
+14
+00:01:15,040 --> 00:01:42,840
+تمام؟ الكالسيوم موجود في الدم في شكلين:
+
+15
+00:01:47,170 --> 00:01:53,650
+تمام؟ حر، مش مربوط بأي شيء، وهو هذا الشكل الـ active.
+
+16
+00:01:53,650 --> 00:01:57,670
+بما أنه مش مربوط، معناه هو اللي بيروح للخلايا،
+
+17
+00:01:57,670 --> 00:02:03,150
+بدخلها عشان تؤدي وظائفها، بتطلع منها، فهو يعني هو
+
+18
+00:02:03,150 --> 00:02:07,470
+الـ free هو الـ active form أو بنسميه الـ ionized
+
+19
+00:02:07,470 --> 00:02:16,820
+form، المتأين المشحون. تمام؟ And the other، و 55% من
+
+20
+00:02:16,820 --> 00:02:22,240
+الكالسيوم اللي موجود في البلازما هو bound calcium،
+
+21
+00:02:22,240 --> 00:02:26,400
+مرتبط، وعلى الأغلب بيكون مرتبط ببروتين، ونوع هذا
+
+22
+00:02:26,400 --> 00:02:31,800
+البروتين هو الـ albumin. إذاً 45% من الكالسيوم free،
+
+23
+00:02:31,800 --> 00:02:38,040
+و 55% من الكالسيوم اللي موجود في بلازما الدم بيكون
+
+24
+00:02:38,040 --> 00:02:42,960
+مرتبط ببروتين اسمه الـ albumin. وهذا المرتبط عادة
+
+25
+00:02:42,960 --> 00:02:49,180
+ما بيكون مشحون. تمام؟ لأن شحنته اتعدّلت، مثلا هو كان
+
+26
+00:02:49,180 --> 00:02:53,160
+موجب والـ albumin سالب، ربطوا في بعض، وبالتالي بطل
+
+27
+00:02:53,160 --> 00:02:58,040
+مشحون، inactive form. يعني بما إنه ارتبط، معناه مش
+
+28
+00:02:58,040 --> 00:03:04,650
+هيقدر يؤدي وظيفته. بنسميه الـ Bound أو الـ Inactive
+
+29
+00:03:04,650 --> 00:03:12,760
+Form، الـ Form اللي مش نشطة. هذا الـ slide كتير مهمة.
+
+30
+00:03:12,760 --> 00:03:17,340
+Too little calcium gets you either a loss of
+
+31
+00:03:17,340 --> 00:03:22,140
+tissue function or soft bones, osteoporosis. بيقصد
+
+32
+00:03:22,140 --> 00:03:28,320
+فيها لو كانت نسبة الكالسيوم جوا العظم كانت قليلة.
+
+33
+00:03:28,320 --> 00:03:35,390
+هذا هيؤدي إلى إحداث الـ Soft Bones، هتصبح العظام هشة،
+
+34
+00:03:35,390 --> 00:03:40,770
+سهلة الكسر، يعني بيصير عندي osteoporosis، هشاشة عظام.
+
+35
+00:03:40,770 --> 00:03:45,650
+وهذه حالة مرضية طبعا. إذا في حال نقص الكالسيوم في
+
+36
+00:03:45,650 --> 00:03:49,450
+المخزن، يعني نقص مستوى الكالسيوم في الـ bones، في
+
+37
+00:03:49,450 --> 00:03:53,030
+العظام. اتفقنا الكالسيوم هو اللي بيعطي الـrigidity،
+
+38
+00:03:53,030 --> 00:03:58,880
+الصلابة للعظم. فلو نقص الكالسيوم، هتصبح العظام سهلة
+
+39
+00:03:58,880 --> 00:04:04,660
+الكسر، soft bones، عظام ناعمة وهشة، osteoporosis، حالة
+
+40
+00:04:04,660 --> 00:04:11,090
+مرضية، نقصد فيها هشاشة عظام. While too much gives you
+
+41
+00:04:11,090 --> 00:04:16,630
+tetany, cardiac arrest and/or lockjaw.  Is from over
+
+42
+00:04:16,630 --> 00:04:21,290
+clinching of muscles or over brittle bones. إيش
+
+43
+00:04:21,290 --> 00:04:26,170
+بيقصد في الشق الآخر؟ الشق الآخر عكس الأول، الشق
+
+44
+00:04:26,170 --> 00:04:32,250
+الآخر بيحكي: لو مستوى الكالسيوم كان في الـ bones أعلى
+
+45
+00:04:32,250 --> 00:04:37,370
+من الحد المسموح، يعني عالي كتير كتير. احنا حكينا هو
+
+46
+00:04:37,370 --> 00:04:41,270
+موجود بكميات كبيرة في الـ bones، ولكن لو زاد عن هذه
+
+47
+00:04:41,270 --> 00:04:48,910
+الكميات، هيؤدي ذلك إلى تصلب العظم، يعني العظم يعني
+
+48
+00:04:48,910 --> 00:04:54,170
+على الرغم من إنه rigid، صلب، لكن مرن، بتحرك، لكن في
+
+49
+00:04:54,170 --> 00:05:00,380
+حال زاد مستوى الكالسيوم وكان أكتر من الطبيعي جوات
+
+50
+00:05:00,380 --> 00:05:04,860
+الـ Bones، راح يؤدي إلى التيتانوس، حيصاب الشخص
+
+51
+00:05:04,860 --> 00:05:09,420
+بتيتانوس في عضلاته، ممكن يصير عنده cardiac arrest،
+
+52
+00:05:09,420 --> 00:05:16,220
+توقف عضلة القلب، نتيجة ارتفاع مستوى الكالسيوم، ممكن
+
+53
+00:05:16,220 --> 00:05:24,430
+يصير عنده lock jaw، يعني فكه أسنانه بيبطل يتحرك، اللي
+
+54
+00:05:24,430 --> 00:05:29,770
+هو مرض الكزاز، بنحكي عنه الـ Tetanus. هذا كله إيش
+
+55
+00:05:29,770 --> 00:05:34,290
+سببه؟ Is from over clinching of muscles. هذا سببه
+
+56
+00:05:34,290 --> 00:05:43,930
+إن العضلات يعني صار فيها انقباض مستمر وجهد، والعظام
+
+57
+00:05:43,930 --> 00:05:47,890
+والعضلات. اتفقنا إنه لما بتكون الـ Calcium أعلى من
+
+58
+00:05:47,890 --> 00:05:52,310
+الحد الطبيعي في الـ Bones، بتصير العضلة يعني خلاص
+
+59
+00:05:52,310 --> 00:05:57,270
+مش قادرة تتحرك، ريجيد كتير، ثلبة كتير كتير، ممكن الشخص
+
+60
+00:05:57,270 --> 00:06:03,110
+يصير عنده الـ Tetany نتيجة الانقباض المستمر
+
+61
+00:06:03,110 --> 00:06:10,380
+للعضلة، ويعني انقباض فوق الطبيعي. طبعا هذا المقصود.
+
+62
+00:06:10,380 --> 00:06:13,800
+إذا من هذه الفقرة بتفهم شغلتين: لو قلّ مستوى الـ
+
+63
+00:06:13,800 --> 00:06:19,740
+calcium في العظم، العظم بيصير هش، بنكسر، لكن بيصير
+
+64
+00:06:19,740 --> 00:06:24,860
+عندي osteoporosis، هشاشة عظام. لكن لو الـ calcium زاد
+
+65
+00:06:24,860 --> 00:06:30,260
+مستواه في العظم أكتر من الطبيعي، بيصير عندي تشنّج في
+
+66
+00:06:30,260 --> 00:06:34,900
+العظم، بيصير عندي tetany، يصاب الشخص بالـtetany.
+
+67
+00:06:34,900 --> 00:06:41,270
+طبعا، okay. Changes in calcium are used to assess bone
+
+68
+00:06:41,270 --> 00:06:47,850
+function. أي تغير في مستوى الكالسيوم هذا مهم جدا،
+
+69
+00:06:47,850 --> 00:06:53,680
+وبيعبر عن وظيفة الـ bone. Higher blood levels
+
+70
+00:06:53,680 --> 00:06:59,500
+usually mean lower bone levels. بيحكيلي: عادة لو كان
+
+71
+00:06:59,500 --> 00:07:04,880
+مستوى الكالسيوم في الدم عالي عالي كتير، أعلى من
+
+72
+00:07:04,880 --> 00:07:09,720
+الطبيعي، هذا بيعبر أن مستوى الكالسيوم في الـ bone
+
+73
+00:07:09,720 --> 00:07:17,020
+بدأ يقل أو حيقل. تمام؟ Usually performed in
+
+74
+00:07:17,020 --> 00:07:20,600
+conjunction with phosphorus determination. عادة ما
+
+75
+00:07:20,600 --> 00:07:24,400
+بنعمل فحص الكالسيوم لحاله؟ دايما كالسيوم وفوسفورس مع
+
+76
+00:07:24,400 --> 00:07:29,400
+بعض، عشان نشيك على وضع الـ bone. Three hormones،
+
+77
+00:07:29,400 --> 00:07:33,900
+ثلاثة هرمونات: الـ parathyroid hormone، هرمونات
+
+78
+00:07:33,900 --> 00:07:39,150
+الغدة جار الدرقية، Vitamin D، والـ Calcitonin. هذا
+
+79
+00:07:39,150 --> 00:07:42,570
+الهرمون بيتم إفرازه من الغدة الدرقية نفسها، من الـ
+
+80
+00:07:42,570 --> 00:07:46,490
+thyroid gland. Are known to regulate serum calcium
+
+81
+00:07:46,490 --> 00:07:50,230
+by altering their secretion rate in response to
+
+82
+00:07:50,230 --> 00:07:54,910
+changes in ionized calcium. ثلاثة هرمونات مسؤولة عن
+
+83
+00:07:54,910 --> 00:08:01,110
+تنظيم مستوى الـ Ionized Calcium، للـ Free Form
+
+84
+00:08:01,110 --> 00:08:05,990
+كالسيوم في الدم. تمام؟ هم اللي بنظموا مستوى الـ
+
+85
+00:08:05,990 --> 00:08:09,870
+Ionized Calcium في الدم، وهنشوف الـ mechanism كيف.
+
+86
+00:08:11,380 --> 00:08:18,100
+ركزوا مع بعض من الرسمة. بيحكيلي: لما مستوى الـ
+
+87
+00:08:18,100 --> 00:08:21,500
+Ionized Calcium، أنا بهمني الـ Free Calcium يا
+
+88
+00:08:21,500 --> 00:08:26,000
+جماعة، لأن هو اللي بيعطي الوظيفة في الجسم. الـ Free
+
+89
+00:08:26,000 --> 00:08:31,000
+Calcium اللي في البلازما بتاعة الدم، لما بيقل مستوى
+
+90
+00:08:31,000 --> 00:08:40,710
+الـ Ionized Calcium في بلازما الدم، هذا إشارة للـ
+
+91
+00:08:40,710 --> 00:08:45,710
+Parathyroid gland إنها تقوم بإفراز الـ Parathyroid
+
+92
+00:08:45,710 --> 00:08:49,730
+hormone. إذن الـ Parathyroid gland، الغدة
+
+93
+00:08:49,730 --> 00:08:54,170
+جار الدرقية، بتستشعر إن في نقص في الـ Ionized
+
+94
+00:08:54,170 --> 00:08:59,010
+calcium في بلازما الدم، فبتقوم بإفراز هرمون اسمه
+
+95
+00:08:59,010 --> 00:09:03,570
+الـ Parathyroid hormone. هذا لما بيتم إفرازه، لو
+
+96
+00:09:03,570 --> 00:09:09,320
+تبعته على الصورة، لما بيتم إفرازه، بيشتغل على two receptors،
+
+97
+00:09:09,320 --> 00:09:13,680
+بيشتغل يعني على مستقبلين أو على مواقع في الجسم. هذا
+
+98
+00:09:13,680 --> 00:09:20,100
+الهرمون بيروح بيشتغل على الـ bone، على العظم،
+
+99
+00:09:20,100 --> 00:09:26,110
+وبيخلي الـ Calcium اللي موجود في الـ bone إنه يطلع
+
+100
+00:09:26,110 --> 00:09:31,710
+لبرا، يطلع على الدم، يعني من المخزن للدم، عشان يزيد
+
+101
+00:09:31,710 --> 00:09:35,890
+مستوى الـ Ionized Calcium. إذن أول شغل للـ
+
+102
+00:09:35,890 --> 00:09:41,190
+Parathyroid hormone، إنها بتروح على الـ bone، لأنه
+
+103
+00:09:41,190 --> 00:09:44,850
+هو المخزن للكالسيوم، وأنا بحاجة في الدم للكالسيوم.
+
+104
+00:09:44,850 --> 00:09:50,430
+وبيصير الـ bone يطلع كالسيوم من عنده لبلازما
+
+105
+00:09:50,430 --> 00:09:56,870
+الدم، تمام؟ والـ action الثاني، الشغل الثاني للـ
+
+106
+00:09:56,870 --> 00:10:00,530
+Parathyroid hormone، إنه بيروح على الكلى،
+
+107
+00:10:03,030 --> 00:10:08,430
+بيخلي الكلى إنها تعمل Reabsorption للكالسيوم،
+
+108
+00:10:08,430 --> 00:10:11,410
+الكلى وظيفتها تطلع الشغلات اللي بدنا نشيلها، و
+
+109
+00:10:11,410 --> 00:10:15,350
+ترجع الشغلات اللي بدنا إياها، فهو بيخلي الكلى تعمل
+
+110
+00:10:15,350 --> 00:10:20,730
+إعادة امتصاص للـ Ionized Calcium، وترجعه لبلازما
+
+111
+00:10:20,730 --> 00:10:24,170
+الدم، لأنه أنا بدي إياه، لأنه فعليا الشخص هذا صار عنده
+
+112
+00:10:24,170 --> 00:10:29,180
+نقص في الـ Ionized Calcium. مش بس هيك، الكلى بتعمل
+
+113
+00:10:29,180 --> 00:10:34,020
+أيضا، الـ Parathyroid hormone بيخلي الكلى إنها
+
+114
+00:10:34,020 --> 00:10:39,800
+تكمل، تكمّل في تصنيع Vitamin D. اتفقنا إنّه
+
+115
+00:10:39,800 --> 00:10:44,400
+Vitamin D بيتصنع في الـ liver، وبيتم إكمال تصنيعه
+
+116
+00:10:44,400 --> 00:10:48,430
+في الـ kidney، في الكلى، صح ولا لأ؟ في الـ kidney، في
+
+117
+00:10:48,430 --> 00:10:53,070
+الكلى، صح ولا لأ؟ إذن الـ Parathyroid hormone كمان
+
+118
+00:10:53,070 --> 00:10:58,550
+بيخلي الكلى إنها تكمل تصنيع Vitamin D. إذن Vitamin
+
+119
+00:10:58,550 --> 00:11:04,490
+D اتصنع، تمام؟ وصار active Vitamin D. إيش بيعمل؟
+
+120
+00:11:04,490 --> 00:11:12,000
+Vitamin D بيخلي إعادة امتصاص الكالسيوم عبر الـ
+
+121
+00:11:12,000 --> 00:11:17,960
+intestine. تمام؟ بمنع الـ calcium يخرج مع الـ stool.
+
+122
+00:11:17,960 --> 00:11:24,560
+صح ولا لأ؟ فبيخلي الـ Vitamin D بيشتغل على الـ
+
+123
+00:11:24,560 --> 00:11:30,060
+intestine، الأمعاء، وبيخلي الأمعاء تعمل Reabsorption
+
+124
+00:11:30,060 --> 00:11:35,140
+للكالسيوم، تعمل له إعادة امتصاص، وترجعه للدم، وما يخرجش
+
+125
+00:11:35,140 --> 00:11:38,620
+مع الـ stool. أنا ما بدي أعمل Excretion له، بالعكس،
+
+126
+00:11:38,620 --> 00:11:42,480
+الدم الـ ionized calcium فيه قليل، فأنا بدي أرجعه
+
+127
+00:11:42,480 --> 00:11:48,960
+للدم. تمام؟ إذا هذه كل الـ mechanism هذا، عشان أزيد
+
+128
+00:11:48,960 --> 00:11:52,840
+مستوى الـ ionized calcium في الدم. تمام؟
+
+129
+00:11:57,180 --> 00:12:04,560
+أما الشق الآخر، في حال ارتفع الـ ionized calcium
+
+130
+00:12:04,560 --> 00:12:08,160
+عندي في الدم، ارتفع عن الوضع الطبيعي، الإنسان
+
+131
+00:12:08,160 --> 00:12:11,640
+الطبيعي لازم يكون ضمن range معين، الـ calcium عنده،
+
+132
+00:12:11,640 --> 00:12:15,360
+الـ ionized calcium. فلو انخفض، حكينا إيش بيصير؟ مين
+
+133
+00:12:15,360 --> 00:12:19,960
+بيشتغل؟ الـ parathyroid hormone. لكن لو ارتفع مستوى
+
+134
+00:12:19,960 --> 00:12:24,060
+الـ ionized calcium في الدم، أنا بدي مين ينزله؟ تمام؟
+
+135
+00:12:24,060 --> 00:12:30,090
+فالشر الآخر بيحكي لي: لو ارتفع مستوى الـ Ionized
+
+136
+00:12:30,090 --> 00:12:38,130
+كالسيوم في الدم، مين هيشتغل؟ لما بيرتفع، اللي هيحسّس
+
+137
+00:12:38,130 --> 00:12:41,950
+ب هذا الارتفاع، الـ Thyroid gland، الغدة الدرقية
+
+138
+00:12:41,950 --> 00:12:47,910
+نفسها، وتقوم بإفراز الـ Calcitonin. هذا هرمون يُفرز
+
+139
+00:12:47,910 --> 00:12:51,610
+من الغدة الدرقية برضه يا جماعة. الـ Calcitonin
+
+140
+00:12:51,610 --> 00:12:56,530
+بيشتغل على موقعين زي، زي الـ Parathyroid hormone.
+
+141
+00:12:57,460 --> 00:13:03,100
+بيشتغل على العظم، وبيشتغل على الـ kidney. بيشتغل على
+
+142
+00:13:03,100 --> 00:13:07,100
+العظم، وإيش بيعمل؟ زي ما هو مكتوب بالـ slide:
+
+143
+00:13:07,100 --> 00:13:12,460
+Stimulates calcium deposition in bones. يمنع خروج
+
+144
+00:13:12,460 --> 00:13:18,020
+الكالسيوم من الـ bone للدم، لأن الدم أصلا مليان
+
+145
+00:13:18,020 --> 00:13:23,360
+ionized calcium. فما بدي ionized calcium زيادة، فبمنع،
+
+146
+00:13:23,360 --> 00:13:27,100
+بيخلي الـ deposition للكالسيوم، يعني بيخلي الكالسيوم
+
+147
+00:13:27,100 --> 00:13:31,360
+في الـ bone، وممنوع يطلع للدم. عكس شغل الـ
+
+148
+00:13:31,360 --> 00:13:36,220
+Parathyroid hormone. إذا منتبهين. وأيضا بيشتغل الـ
+
+149
+00:13:36,220 --> 00:13:40,340
+Calcitonin على الـ kidney، وإيش بيعمل للـ kidney؟
+
+150
+00:13:40,340 --> 00:13:45,920
+و بيخلي الكلى تعمل Excretion للكالسيوم، بيخلي
+
+151
+00:13:45,920 --> 00:13:49,960
+الكلى تتخلص من الكالسيوم عن طريق الـ urine، و
+
+152
+00:13:49,960 --> 00:13:54,240
+ممنوع تعمل له Reabsorption. وبهيك ترجع مستوى الـ
+
+153
+00:13:54,240 --> 00:13:58,680
+Ionized Calcium في الدم طبيعياً. تمام؟ إذا اللي بنظم
+
+154
+00:13:58,680 --> 00:14:02,460
+مستوى الكالسيوم في الدم، الـ parathyroid hormone،
+
+155
+00:14:02,460 --> 00:14:07,580
+هرمونات الغدة جار الدرقية، والـ Calcitonin اللي
+
+156
+00:14:07,580 --> 00:14:11,460
+بيفرز من الغدة الدرقية، وبرضه Vitamin D. العبارة
+
+157
+00:14:11,460 --> 00:14:18,340
+عن هرمون في الآخر صنّفه برضه، مسؤول عن تنظيم مستوى
+
+158
+00:14:18,340 --> 00:14:22,740
+الكالسيوم في الدم. تمام؟ إذا هذه ثلاثة هرمونات بتنظم
+
+159
+00:14:22,740 --> 00:14:27,190
+مستوى الكالسيوم في الدم. الـ Principle of the Method،
+
+160
+00:14:27,190 --> 00:14:31,650
+مبدأ طريقتنا، Calorimetric Reaction. الكالسيوم بيروح
+
+161
+00:14:31,650 --> 00:14:35,870
+يتفاعل مع مادة موجودة في الـ Reagent. محصلة التفاعل
+
+162
+00:14:35,870 --> 00:14:39,530
+إعطاء مادة ملونة، بنقيس شدة هاد المادة،
+
+163
+00:14:39,530 --> 00:14:44,800
+والـ absorbance تبعها على جهاز الـSpectrophotometer. بمقارنة
+
+164
+00:14:44,800 --> 00:14:48,940
+الكالسيوم في المجلد. تعتمد على صناعة مجلد ألوان
+
+165
+00:14:48,940 --> 00:14:54,100
+complex بين كالسيوم وأورثو كريزوفالاتين في مجلد
+
+166
+00:14:54,100 --> 00:14:57,620
+alkaline media. الـ Reagent اللي بيجي من الشركة بيحتوي
+
+167
+00:14:57,620 --> 00:15:01,620
+على مادة الـ Ortho-chrysophthalene. هذه اللي
+
+168
+00:15:01,620 --> 00:15:06,220
+بتتفاعل مع الكالسيوم. الـ alkaline pH، يعني الـ
+
+169
+00:15:06,220 --> 00:15:12,040
+reaction بتكون الـ pH تبعها alkaline. محصلة التفاعل
+
+170
+00:15:12,040 --> 00:15:17,920
+colored complex، مادة ملونة، و عادة اللون اللي بيظهر
+
+171
+00:15:17,920 --> 00:
+
+223
+00:19:17,080 --> 00:19:23,280
+ممكن يصير acidic pH وهذه حالة مرضية ليش؟ لأنه إذا
+
+224
+00:19:23,280 --> 00:19:28,360
+أخذتوها بالحيوية لما نجهد العضلة أو نشتغل مجهود في
+
+225
+00:19:28,360 --> 00:19:35,360
+مجهود عضلي جبار بتتكون مادة الـ lactic acid أو الـ
+
+226
+00:19:35,360 --> 00:19:40,120
+lactic acid أو الـ lactate صح ولا لأ؟ هذه المادة
+
+227
+00:19:40,120 --> 00:19:45,420
+تتكون بكميات أكبر من الطبيعي إذا أنت عملت مجهود
+
+228
+00:19:45,420 --> 00:19:49,740
+عضلي. وجود هذه المادة، دي مادة حامضية، وجودها في الدم
+
+229
+00:19:49,740 --> 00:19:55,440
+already سيخفض من مستوى الـ pH بسرعة، بتأثر على
+
+230
+00:19:55,440 --> 00:20:00,390
+مستوى الـ pH. الـ pH سيكون neutral لو أنت عملت مجهود
+
+231
+00:20:00,390 --> 00:20:05,090
+عضلي، ستتكون مادة اسمها الـ lactic acid. هذه المادة
+
+232
+00:20:05,090 --> 00:20:10,430
+الحامضية ستخفض مستوى الـ pH، ويصير الـ pH acidic، تمام؟
+
+233
+00:20:11,610 --> 00:20:18,110
+ولمّا يصير الـ pH acidic، بيحكي لي هذا يزيد مستوى ال
+
+234
+00:20:18,110 --> 00:20:23,610
+ionized calcium في الدم. إذا الـ venous stasis، ربط
+
+235
+00:20:23,610 --> 00:20:27,630
+التورنيكات فترة طويلة، الـ forearm exercise، عمل
+
+236
+00:20:27,630 --> 00:20:31,810
+مجهود، كل هذه الشغلات ستزيد مستوى الـ ionized
+
+237
+00:20:31,810 --> 00:20:37,080
+calcium بشكل خاطئ في الدم. إيش السبب؟ صار في عندي
+
+238
+00:20:37,080 --> 00:20:43,540
+decrease in pH، قل الـ pH تبع الدم. ليش؟ بسبب إنتاج
+
+239
+00:20:43,540 --> 00:20:48,340
+الـ lactic acid في العضلة. في العضلة بيصير نتيجة
+
+240
+00:20:48,340 --> 00:20:54,420
+إجهادها، بتتكون مادة حامضية اسمها الـ lactic acid، هي
+
+241
+00:20:54,420 --> 00:20:59,380
+اللي بتنزل الـ pH، وبالتالي هذا يؤدي إلى رفع مستوى
+
+242
+00:20:59,380 --> 00:21:03,880
+الـ ionized calcium في الدم. واضح؟ هذه شغلات بدنا
+
+243
+00:21:03,880 --> 00:21:09,190
+نتجنبها. Exposing the sample to air will cause an
+
+244
+00:21:09,190 --> 00:21:13,570
+increase in pH. إن العكس بيحكي لي لو سحبت عينة من
+
+245
+00:21:13,570 --> 00:21:19,810
+شخص، وعرضت العينة للـ air، للهواء لفترة طويلة، يعني دائماً
+
+246
+00:21:19,810 --> 00:21:26,290
+بدنا نسكر الـ tube تبعت السحب. لو عرضت الـ sample
+
+247
+00:21:26,290 --> 00:21:32,520
+للهواء، معناه في oxygen أكثر من الـ CO2. الـ oxygen
+
+248
+00:21:32,520 --> 00:21:40,500
+سيقلل الـ CO2، هيقلل هذا كله، سيَزيد مستوى الـ pH. ليش؟
+
+249
+00:21:40,500 --> 00:21:45,200
+لأنه بيحكي لي سينخفض مستوى الـ CO2، والـ oxygen
+
+250
+00:21:45,200 --> 00:21:49,360
+سيَزيد، وبالتالي هذا كله، هذا الـ reaction كله، سيَزيد
+
+251
+00:21:49,360 --> 00:21:54,960
+الـ pH. يعني الـ pH تبع الدم، هيصير تبع العينة، سيصير
+
+252
+00:21:54,960 --> 00:22:01,370
+alkaline، مش neutral. ولمّا بيصير الدم alkaline، الـ
+
+253
+00:22:01,370 --> 00:22:05,310
+ionized calcium ينخفض. إذا نطلع من هذا الـ slide
+
+254
+00:22:05,310 --> 00:22:09,950
+بشغلتين: في حال كان الـ pH تبع الدم عند الإنسان
+
+255
+00:22:09,950 --> 00:22:13,590
+الطبيعي، neutral، متعادل، هذا الموقف، مستوى الـ
+
+256
+00:22:13,590 --> 00:22:19,030
+ionized calcium بيكون طبيعي. لكن لو انخفض الـ pH،
+
+257
+00:22:19,030 --> 00:22:22,610
+يعني صار الـ pH acidic، وهذه حالة مرضية. أي إنسان
+
+258
+00:22:22,610 --> 00:22:26,410
+بيكون عنده الـ pH تبع الدم acidic، حالة مرضية صعبة.
+
+259
+00:22:26,410 --> 00:22:33,090
+لما بيصير الدم acidic، الـ ionized calcium يزيد. لما
+
+260
+00:22:33,090 --> 00:22:38,930
+بيصير الدم alkaline، يعني الـ pH عالية، الـ ionized
+
+261
+00:22:38,930 --> 00:22:42,370
+calcium مستوى في الدم ينخفض، تمام؟
+
+262
+00:22:46,300 --> 00:22:51,960
+طبعاً الـ normal range للكالسيوم عند الـ normal
+
+263
+00:22:51,960 --> 00:22:55,560
+range، هنا قصده الـ total calcium. انتبهوا، الـ
+
+264
+00:22:55,560 --> 00:22:59,700
+normal range لـ total calcium، الـ ionized زائد الـ
+
+265
+00:22:59,700 --> 00:23:05,440
+bound، عند الـ adult من 8.5 لـ 10.5 milligram per
+
+266
+00:23:05,440 --> 00:23:09,040
+deciliter.  فحصوا اللي عندكم، عندكم بالـ slide مكتوب
+
+267
+00:23:09,040 --> 00:23:13,440
+microgram، لا. الكالسيوم يُقاس بالـ milligram per
+
+268
+00:23:13,440 --> 00:23:18,900
+deciliter. عند الـ children من عشرة لـ اثني عشر milligram
+
+269
+00:23:18,900 --> 00:23:23,340
+per deciliter. ملاحظين أعلى من الـ adult، مستوى الـ total
+
+270
+00:23:23,340 --> 00:23:27,420
+calcium عندهم، لأنه أصلاً لازم يكون عندهم عالي عشان
+
+271
+00:23:27,420 --> 00:23:31,640
+جسمهم يبني، عشان العظم عندهم ينمو، فبدهم calcium
+
+272
+00:23:31,640 --> 00:23:36,960
+أكثر، تمام؟ لو بدي أحولها بالـ micro mole per liter
+
+273
+00:23:36,960 --> 00:23:43,660
+زي ما احنا شايفين، حالات بيصير فيها hypocalcemia،
+
+274
+00:23:43,660 --> 00:23:49,340
+يعني انخفاض مستوى، هنا يقصد الـ ionized calcium في
+
+275
+00:23:49,340 --> 00:23:53,360
+الدم. الـ hypocalcemia معناه في عندي انخفاض في
+
+276
+00:23:53,360 --> 00:23:58,240
+مستوى الـ ionized calcium في الدم. متى بيصير هذا؟
+
+277
+00:23:58,880 --> 00:24:02,960
+بيصير عندما يكون عندي vitamin D deficiency. لو
+
+278
+00:24:02,960 --> 00:24:06,420
+عندي نقص في vitamin D، إيش بيعمل؟ هو اللي بيحفظ
+
+279
+00:24:06,420 --> 00:24:11,360
+الأمعاء تعمل إعادة امتصاص للكالسيوم، وتمنع خروجه عبر
+
+280
+00:24:11,360 --> 00:24:15,540
+الـ stool. فلو ما فيش vitamin D، المعنى الكالسيوم
+
+281
+00:24:15,540 --> 00:24:21,220
+سيخرج مع الـ stool، ويقل مستوى، معناه هيصير عندي
+
+282
+00:24:21,220 --> 00:24:26,870
+hypocalcemia. الـ hypoparathyroidism، يعني انخفاض
+
+283
+00:24:26,870 --> 00:24:32,370
+مستوى هرمون الباراثيرويد. هرمون، لما ينقص هرمون الباراثيرويد،
+
+284
+00:24:32,370 --> 00:24:36,470
+هرمون، ان نقص عند الإنسان، صار عنده انخفاض في ال
+
+285
+00:24:36,470 --> 00:24:41,080
+ionized calcium. لو هو طبيعي، الـ parathyroid هرمون،
+
+286
+00:24:41,080 --> 00:24:45,000
+إيش وظيفتها؟ تروح للكلية، تحكي لها اعمل إعادة
+
+287
+00:24:45,000 --> 00:24:49,200
+امتصاص، تروح للـ bone، اطلع الكالسيوم من الـ bone
+
+288
+00:24:49,200 --> 00:24:53,620
+للدم. لكن لو أنت أصلاً عندك hypoparathyroidism،
+
+289
+00:24:53,620 --> 00:24:57,240
+يعني عندك انخفاض أصلاً في الهرمون، معناه الـ action
+
+290
+00:24:57,240 --> 00:25:01,860
+تبع هذا الهرمون مش هيصير، معناه سيظل الجسم يعاني
+
+291
+00:25:01,860 --> 00:25:07,960
+من الـ hypocalcemia. حالات الـ alkalosis أو الـ alkalemia،
+
+292
+00:25:07,960 --> 00:25:11,580
+الـ alkalemia،
+
+293
+00:25:11,580 --> 00:25:17,040
+أو الـ alkalosis، اللي هو ارتفاع الـ pH تبع الدم.
+
+294
+00:25:17,040 --> 00:25:22,520
+الأشخاص اللي عندهم الـ pH عالي، مش neutral، هدول
+
+295
+00:25:22,520 --> 00:25:26,540
+الأشخاص بيكون عندهم نقص في الـ ionized calcium، زي
+
+296
+00:25:26,540 --> 00:25:30,380
+ما حكيناها بالـ slide اللي فات، تمام؟ أما الـ
+
+297
+00:25:30,380 --> 00:25:34,160
+hypercalcemia، ارتفاع مستوى الـ ionized calcium في
+
+298
+00:25:34,160 --> 00:25:39,000
+الدم، عدة أسباب: hyperparathyroidism، يعني الـ
+
+299
+00:25:39,000 --> 00:25:43,220
+parathyroid هرمون، الـ action، يعني الهرمون موجود
+
+300
+00:25:43,220 --> 00:25:48,300
+بكميات كبيرة، أكثر من الطبيعي، hyper، وبالتالي
+
+301
+00:25:48,300 --> 00:25:51,860
+سيشتغل على الكلية، وسيشتغل على الـ bone بشكل أكبر،
+
+302
+00:25:51,860 --> 00:25:56,980
+سيُخرج الـ calcium من الـ bone للدم، سيَروح للكلية يعطيها
+
+303
+00:25:56,980 --> 00:26:01,200
+أوامر إعادة امتصاص للكالسيوم دائماً، وبالتالي إيش
+
+304
+00:26:01,200 --> 00:26:05,220
+المحصلة؟ سيزيد مستوى الـ ionized calcium. malignancy
+
+305
+00:26:05,220 --> 00:26:10,200
+of bone، سرطانات في الـ bone، سيؤدي ذلك إلى تسرب
+
+306
+00:26:10,200 --> 00:26:13,960
+الكالسيوم من الـ bone إلى الـ blood. سيخرج الكالسيوم
+
+307
+00:26:13,960 --> 00:26:19,680
+من العظم إلى الدم. في حالة الـ malignancy، الـ
+
+308
+00:26:19,680 --> 00:26:23,540
+thyrotoxicosis. thyrotoxicosis، وجود... ستأخذوا هذه
+
+309
+00:26:23,540 --> 00:26:28,180
+المصطلحات في كورس الهرمونات. وجود مشكلة في الـ
+
+310
+00:26:28,180 --> 00:26:32,480
+thyroid hormone. thyroid hormone، ترتفع أكثر من
+
+311
+00:26:32,480 --> 00:26:37,260
+الطبيعي. إذا سمعتوا عنهم، الـ T3 و T4، تمام؟ طب إيش
+
+312
+00:26:37,260 --> 00:26:43,210
+دخلها؟ بحكم أن الغدة الدرقية جنب الغدة
+
+313
+00:26:43,210 --> 00:26:47,430
+الجاردرقية، هما جنب بعض، موجودين، فلما بيصير عندي
+
+314
+00:26:47,430 --> 00:26:50,690
+مشكلة بالغدة الدرقية، already ستؤثر على الغدة
+
+315
+00:26:50,690 --> 00:26:55,430
+الثانية، الجاردرقية. هذه حالة الـ thyrotoxicosis، أيضاً،
+
+316
+00:26:55,430 --> 00:26:58,670
+في الـ thyrotoxicosis، مش هرمونات الغدة الدرقية بس
+
+317
+00:26:58,670 --> 00:27:02,670
+ترتفع، لهم T3 و T4، أيضاً الـ parathyroid hormone
+
+318
+00:27:02,670 --> 00:27:07,430
+سيرتفع، يعني سيصير عندي، آسف، سيصير عندي الـ
+
+319
+00:27:07,430 --> 00:27:12,020
+hyperparathyroidism. vitamin D intoxication. إيش
+
+320
+00:27:12,020 --> 00:27:16,400
+يعني؟ يعني vitamin D موجود بتركيز عالي جداً جداً،
+
+321
+00:27:16,400 --> 00:27:19,840
+أعلى من الطبيعي، وهذا التركيز يكون toxic، يعني ممكن
+
+322
+00:27:19,840 --> 00:27:25,220
+يموت الإنسان، أو يدمر عنده أنسجة معينة. فلما بيزيد
+
+323
+00:27:25,220 --> 00:27:29,820
+أيضاً vitamin D،  سيهحفز الأمعاء بشكل مضاعف،
+
+324
+00:27:29,820 --> 00:27:34,040
+ستعمل إعادة امتصاص للكالسيوم. ممكن يكون حالات إيدوباثك
+
+325
+00:27:34,040 --> 00:27:38,540
+مجهولة، تؤدي لزيادة مستوى الـ ionized calcium في
+
+326
+00:27:38,540 --> 00:27:41,710
+الدم. السلام عليكم ورحمة الله. نجي للفحص الثاني،
+
+327
+00:27:41,710 --> 00:27:46,210
+الفوسفور. الفوسفور is an essential mineral for
+
+328
+00:27:46,210 --> 00:27:50,010
+tissue bone formation and is required by every
+
+329
+00:27:50,010 --> 00:27:53,730
+cell in the body for normal function. الفوسفور من
+
+330
+00:27:53,730 --> 00:27:58,030
+العناصر المعدنية المهمة التي تحتاجها جميع الخلايا
+
+331
+00:27:58,030 --> 00:28:04,410
+من أجل أداء وظيفتها، وأيضاً عشان الـ bone formation، لما
+
+332
+00:28:04,410 --> 00:28:09,990
+بيصير، تكوين العظام.  أيضاً الفوسفور تحتاجه العظام
+
+333
+00:28:10,110 --> 00:28:17,430
+من أجل تكوينها، تمام؟ approximately، حوالي 85% من ال
+
+334
+00:28:17,430 --> 00:28:21,550
+body phosphorus is found in bone and in teeth. خمسة
+
+335
+00:28:21,550 --> 00:28:26,410
+وثمانين في المائة من الفوسفور مخزن داخل العظم
+
+336
+00:28:26,410 --> 00:28:30,990
+مع الكالسيوم. هو الكالسيوم والفوسفور ماشيين مع بعض، مخزن داخل
+
+337
+00:28:30,990 --> 00:28:35,030
+العظم وفي الأسنان أيضاً، وفي الأسنان. الـ low
+
+338
+00:28:35,030 --> 00:28:39,290
+levels of phosphorus، يعني انخفاض مستوى ال
+
+339
+00:28:39,290 --> 00:28:45,370
+phosphorus في الدم، can be caused by، من الذي يسببه الـ
+
+340
+00:28:45,370 --> 00:28:50,150
+hypervitaminosis D، primary hyperparathyroidism، renal
+
+341
+00:28:50,150 --> 00:28:54,310
+tubular disorder، الـ antacid، أو الـ malabsorption.
+
+342
+00:28:54,310 --> 00:28:57,890
+ركزوا معي، شغلتين شوية بعيد عن الكلام هذا،
+
+343
+00:28:59,050 --> 00:29:05,130
+بتكونوا تعرفوا أن vitamin D، اتفقنا أنه يحفظ
+
+344
+00:29:05,130 --> 00:29:10,470
+إعادة امتصاص الكالسيوم، صح ولا لأ؟ أيضاً شغله مع
+
+345
+00:29:10,470 --> 00:29:15,170
+الفوسفور نفس الكلام، vitamin D اللي بيشتغل على
+
+346
+00:29:15,170 --> 00:29:22,530
+الأمعاء، ويحفظ الأمعاء أيضاً تعمل إعادة امتصاص لـ
+
+347
+00:29:22,530 --> 00:29:26,750
+phosphorus في الدم، وممنوع يطلع برا الـ stool، يعني
+
+348
+00:29:26,750 --> 00:29:31,910
+ممنوع يطلع مع الـ stool، تمام؟ إذا شغل vitamin D للـ
+
+349
+00:29:31,910 --> 00:29:36,370
+phosphorus والكالسيوم زي بعض، إنه بيصير لهم إعادة
+
+350
+00:29:36,370 --> 00:29:41,430
+امتصاص، تمام؟ أما الـ parathyroid hormone، هذه
+
+351
+00:29:41,430 --> 00:29:41,950
+الغدة
+
+352
+00:29:45,230 --> 00:29:49,250
+الباراثيرويد هرمون. هذا الهرمون، اتفقنا أنه بيشتغل
+
+353
+00:29:49,250 --> 00:29:53,990
+على البون، وبيشتغل على الكلية. شغله على الكلية، أنه
+
+354
+00:29:53,990 --> 00:30:00,010
+يعمل إعادة امتصاص للكالسيوم، صح ولا لا؟ لكن شغله مع
+
+355
+00:30:00,010 --> 00:30:04,870
+الفوسفور مختلف، شغله مع الفوسفور أنه يحفظ الـ
+
+356
+00:30:04,870 --> 00:30:09,450
+parathyroid hormone يحفظ الكلية تعمل excretion
+
+357
+00:30:09,450 --> 00:30:15,070
+للفوسفور، تمام؟  برا، يطرحه مع الـ urine. إذا شغل
+
+358
+00:30:15,070 --> 00:30:20,090
+vitamin D للكالسيوم والفوسفور واحد، وشغل الـ
+
+359
+00:30:20,090 --> 00:30:27,000
+parathyroid hormone، وشغل الـ parathyroid هرمون
+
+360
+00:30:27,000 --> 00:30:32,280
+للفوسفور والكالسيوم عكس بعض،  بيُخرج الكالسيوم برا
+
+361
+00:30:32,280 --> 00:30:39,160
+الجسم مع اليورين، وبتحفظ الكلية، شغل الـ parathyroid
+
+362
+00:30:39,160 --> 00:30:43,720
+هرمون على الكلية، أنه بتحكي للكلية اعملي إعادة امتصاص
+
+363
+00:30:43,720 --> 00:30:49,400
+للكالسيوم، واعملي excretion للفوسفور مع اليورين.
+
+364
+00:30:49,400 --> 00:30:56,550
+تمام؟ إذن، ينخفض مستوى الفوسفور في الدم لو صار عندي
+
+365
+00:30:56,550 --> 00:31:02,670
+hypervitaminosis D. طب كيف؟ هتحكولي أن vitamin D
+
+366
+00:31:02,670 --> 00:31:08,770
+بالعكس، يعمل إعادة امتصاص للفوسفور، ويرجعه على
+
+367
+00:31:08,770 --> 00:31:14,860
+الدم. صحيح هذا الوضع الطبيعي، لكن لو زاد vitamin D عن
+
+368
+00:31:14,860 --> 00:31:21,440
+حدّه، يعني صار intoxication، يعني وصل لـ dose، لجرعة
+
+369
+00:31:21,440 --> 00:31:26,080
+السمية في الجسم، hypervitaminosis، يعني عالي كثير
+
+370
+00:31:26,080 --> 00:31:30,540
+كثير، سيحفظ الأمعاء تعمل excretion للـ phosphorus
+
+371
+00:31:30,540 --> 00:31:35,080
+مع الـ stool، تمام؟ لكن هو الطبيعي يعمل إعادة
+
+372
+00:31:35,080 --> 00:31:39,380
+امتصاص، لكن لو زاد مستوى vitamin D، سيعمل
+
+373
+00:31:39,380 --> 00:31:44,270
+شغل عكس شغله الطبيعي. primary hyperparathyroidism،
+
+374
+00:31:44,270 --> 00:31:49,430
+يعني حدوث ارتفاع في الـ parathyroid هرمون بشكل
+
+375
+00:31:49,430 --> 00:31:53,290
+هائل، hyper. هذه الحالة، اتفقنا، ما الـ parathyroid
+
+376
+00:31:53,290 --> 00:31:57,750
+هرمون إيش بتعمل؟ بتعمل excretion للفوسفور مع
+
+377
+00:31:57,750 --> 00:32:01,270
+اليورين، وبالتالي لو زاد هذا الهرمون، معناه الـ
+
+378
+00:32:01,270 --> 00:32:06,010
+excretion سيزيد، وبالتالي سيقل مستوى الفوسفور في
+
+379
+00:32:06,010 --> 00:32:11,780
+الدم، لأنه في هرمون يحفظ خروجه برا الجسم. renal
+
+380
+00:32:11,780 --> 00:32:16,560
+tubular disorder، مشاكل في الـ tubules تبع الكلية، مش
+
+381
+00:32:16,560 --> 00:32:21,040
+قادرة الـ tubules تعمل إعادة امتصاص، وبالتالي بتخرج
+
+382
+00:32:21,040 --> 00:32:24,640
+الفوسفور برا مع الـ urine. الناس اللي بتاخد anti
+
+383
+00:32:24,640 --> 00:32:29,940
+acid، بتاخد الأدوية ضد الحموضة، أيضاً هذه بتخفض مستوى
+
+384
+00:32:29,940 --> 00:32:33,280
+الفوسفور في الدم. أو الـ malabsorption، أكيد شخص عنده
+
+385
+00:32:33,280 --> 00:32:38,740
+سوء امتصاص، فعلى الفاضي، إيش ما يأكل وإيش ما يشرب، مش
+
+386
+00:32:38,740 --> 00:32:45,000
+هيكون عنده امتصاص للشغلة وإعادة امتصاص، تمام؟ high
+
+387
+00:32:45,000 --> 00:32:49,180
+levels of phosphorus، أما ارتفاع مستوى الفوسفور في
+
+388
+00:32:49,180 --> 00:32:53,960
+الدم، can be caused by، إذا أنت أكلت أكلات مليانة
+
+389
+00:32:53,960 --> 00:32:58,840
+فوسفور، أكيد سيرتفع المستوى. bone metastasis، حدوث
+
+390
+00:32:58,840 --> 00:33:04,790
+سرطان في العظم.  حكيت لكم، ستتسرب... ستتسرب المعادن
+
+391
+00:33:04,790 --> 0
+
+445
+00:37:06,770 --> 00:37:09,090
+Reabsorption in the kidney
+
+446
+00:37:13,510 --> 00:37:19,490
+بشتغل على الأمعاء وعلى الكليتين وبعمل إعادة
+
+447
+00:37:19,490 --> 00:37:23,470
+امتصاص للفوسفات وبالتالي تركيز الفوسفات سيزيد في
+
+448
+00:37:23,470 --> 00:37:28,490
+الدم، وأيضاً Vitamin D بشتغل على الكلى وبحفظ
+
+449
+00:37:28,490 --> 00:37:32,630
+الكلى تعمل إعادة امتصاص للفوسفور، تعمل
+
+450
+00:37:32,630 --> 00:37:38,360
+Reabsorption للفوسفور، أما الـ Parathyroid hormone
+
+451
+00:37:38,360 --> 00:37:42,560
+بشتغل  مش على الأمعاء لكن بشتغل على الكلى،
+
+452
+00:37:42,560 --> 00:37:46,840
+الكلى نفسها lowers blood concentrations by
+
+453
+00:37:46,840 --> 00:37:51,120
+increasing renal excretion، يخفض الـ Parathyroid
+
+454
+00:37:51,120 --> 00:37:56,100
+hormone مستوى الفوسفور من خلال أنه بيحفظ
+
+455
+00:37:56,100 --> 00:38:01,440
+الكلى تعمل إخراج للفوسفور خارج الجسم وبالتالي سيقل
+
+456
+00:38:01,440 --> 00:38:06,720
+مستوى الفوسفور في الدم، principle of the method زي
+
+457
+00:38:06,720 --> 00:38:11,460
+طريقة الكالسيوم، إنها طريقة colorimetric، أن الفوسفور
+
+458
+00:38:11,460 --> 00:38:15,440
+الذي في بلازما الدم يرتبط مع مادة موجودة في الـ
+
+459
+00:38:15,440 --> 00:38:19,760
+reagent ويحدث تفاعل يعطي complex ملون، الـ
+
+460
+00:38:19,760 --> 00:38:23,040
+complex هنا يكون لونه أزرق، اللون الذي ينتج عن
+
+461
+00:38:23,040 --> 00:38:28,160
+التفاعل أزرق، تمام؟ الـ Organic Phosphorus، الفوسفور
+
+462
+00:38:28,160 --> 00:38:34,620
+الموجود في الدم Reacts with molybdic acid forming
+
+463
+00:38:34,620 --> 00:38:40,180
+a phosphomolybdic complex، الموليبدك أسيد هذا حمض
+
+464
+00:38:40,180 --> 00:38:43,530
+موجود في الـ Reagent، يتفاعل مع الـ Inorganic
+
+465
+00:38:43,530 --> 00:38:47,270
+Phosphorus الموجود في عينة المريض، يعطيني
+
+466
+00:38:47,270 --> 00:38:51,830
+Complex M1، it is subsequent reduction in alkaline
+
+467
+00:38:51,830 --> 00:38:56,870
+medium originates a blue color، فحصل تفاعل، اللون
+
+468
+00:38:56,870 --> 00:39:01,890
+الأزرق، و الـ pH بتكون alkaline تبع الـ reagent، الـ
+
+469
+00:39:01,890 --> 00:39:05,130
+intensity of the color formed is proportional to
+
+470
+00:39:05,130 --> 00:39:07,730
+the inorganic phosphorus concentration in the
+
+471
+00:39:07,730 --> 00:39:11,070
+sample، شدة اللون تتناسب طردياً مع تركيز
+
+472
+00:39:11,070 --> 00:39:16,260
+الفوسفور غير العضوي الموجود في بلازما الدم، الـ
+
+473
+00:39:16,260 --> 00:39:22,000
+Reference Range للفوسفور عند البالغين من 2.5 إلى 5
+
+474
+00:39:22,000 --> 00:39:26,680
+milligram per deciliter،  أيضاً، الوحدة ليست بالـ
+
+475
+00:39:26,680 --> 00:39:31,560
+micro، عند الأطفال من 4 إلى 7، أيضاً تلاحظون الـ
+
+476
+00:39:31,560 --> 00:39:34,580
+Total Calcium و الفوسفور أعلى عند الأطفال
+
+477
+00:39:34,580 --> 00:39:38,900
+لأن عظامهم لازالت في مرحلة بناء، وبالتالي الـ Bone
+
+478
+00:39:38,900 --> 00:39:43,320
+Formation، تكوين العظام يتطلب وجود كالسيوم و
+
+479
+00:39:43,320 --> 00:39:48,720
+فوسفور، تمام؟  لو أردنا التركيز بالـ Micromole per
+
+480
+00:39:48,720 --> 00:39:54,680
+liter، فالوحدة بالـ milligram per deciliter سريعة
+
+481
+00:39:54,680 --> 00:39:58,880
+الوحده الأخرى millimol per liter، نريد التحويل من
+
+482
+00:39:58,880 --> 00:40:02,760
+milligram per deciliter إلى millimol per liter، غيروا
+
+483
+00:40:02,760 --> 00:40:07,720
+عندكم، ليس micromol per liter،  millimol و milligram
+
+484
+00:40:07,720 --> 00:40:11,040
+تمام؟ وفي الـ total calcium نفس الوحدات milligram
+
+485
+00:40:11,040 --> 00:40:18,280
+per deciliter و millimol per liter، الـ Alkaline
+
+486
+00:40:18,280 --> 00:40:22,340
+Phosphatase،  لقد تحدثنا عنه كثيراً في حالات
+
+487
+00:40:22,340 --> 00:40:27,840
+التشخيص لوضع الكبد، على الكبد، صحيح أم لا؟
+
+488
+00:40:27,840 --> 00:40:31,020
+Alkaline Phosphatase is an enzyme present in
+
+489
+00:40:31,020 --> 00:40:34,720
+almost all parts of the organism, being
+
+490
+00:40:34,720 --> 00:40:38,310
+particularly high in: Liver, Placenta,
+
+491
+00:40:38,670 --> 00:40:42,810
+Intestine, Kidney، وجدنا أن الـ ALP عبارة عن
+
+492
+00:40:42,810 --> 00:40:48,210
+إنزيم موجود تقريباً في جميع أنسجة الجسم، يعني كل
+
+493
+00:40:48,210 --> 00:40:52,630
+الأعضاء الموجودة في الجسم تحتوي على ALP، تحتوي على الـ Alkaline
+
+494
+00:40:52,630 --> 00:40:58,490
+Phosphatase، ولكن موجود بتركيز أعلى في خمس مناطق
+
+495
+00:40:58,490 --> 00:41:02,790
+يرتفع تركيزه في العظم والكبد والمشيمة و
+
+496
+00:41:02,790 --> 00:41:08,070
+الأمعاء و الكلى، تمام؟ Both increases and
+
+497
+00:41:08,070 --> 00:41:11,430
+decreases of plasma ALP are of clinical importance
+
+498
+00:41:11,430 --> 00:41:16,170
+clinically،  يخبرنا أن انخفاض أو ارتفاع مستوى ALP
+
+499
+00:41:16,170 --> 00:41:22,650
+مهم جداً في التشخيص، Causes of increased plasma ALP
+
+500
+00:41:22,650 --> 00:41:27,050
+ما هي الأشياء التي ترفع من مستوى ALP في الدم؟
+
+501
+00:41:27,050 --> 00:41:31,170
+يعني تزيد تركيز هذا الإنزيم في الدم، الـ Paget
+
+502
+00:41:31,170 --> 00:41:34,630
+Disease of Bone، ستأخذونه مع الدكتور مازن، Paget
+
+503
+00:41:34,630 --> 00:41:40,750
+Disease، مرض عظمي يصيب العظام، يبدأ يعني في هذا
+
+504
+00:41:40,750 --> 00:41:45,310
+المرض، يخرج ALP من العظم إلى الدم
+
+505
+00:41:45,310 --> 00:41:48,890
+وبالتالي يزيد تركيزه في الدم، حالات الـ
+
+506
+00:41:48,890 --> 00:41:54,690
+Obstructive Liver Disease، تكون  يعني حصوات في الـ
+
+507
+00:41:54,690 --> 00:42:00,160
+Biliary Duct، في القناة الصفراوية، وبالتالي الخلايا
+
+508
+00:42:00,160 --> 00:42:04,540
+المكونة للصفراء تبدأ تفرز ALP، وجدنا
+
+509
+00:42:04,540 --> 00:42:10,240
+أخذنا هذا الكلام، حالات التهاب الكبد، حالات الـ Hepatitis، التهاب خلايا
+
+510
+00:42:10,240 --> 00:42:16,800
+الكبد، حالات الـ Hepatotoxicity caused by drug، يعني
+
+511
+00:42:16,800 --> 00:42:23,540
+حدوث مشكلة في خلايا الكبد بسبب تناول دواء معين
+
+512
+00:42:23,540 --> 00:42:29,330
+أدى إلى سمية لهذه الخلايا، أيضاً سيرفع من
+
+513
+00:42:29,330 --> 00:42:33,110
+مستوى ALP، حالات هشاشة العظام، تشبه الـ
+
+514
+00:42:33,110 --> 00:42:36,970
+Osteoporosis، الفرق بينهما بسيط، نتجاوزه، بنقول نفس
+
+515
+00:42:36,970 --> 00:42:41,170
+الأشياء، أن فيها تلف في العظم، وبالتالي ALP يرتفع
+
+516
+00:42:41,170 --> 00:42:46,910
+تركيزه في العظم، فيخرج من العظم إلى الدم، Causes of
+
+517
+00:42:46,910 --> 00:42:50,990
+decreased plasma ALP، مستوى ALP ينخفض في الدم
+
+518
+00:42:50,990 --> 00:42:55,770
+في حالات التقزم، أو القزمة، يتحدثون
+
+519
+00:42:55,770 --> 00:43:00,230
+عنها، و نقص فيتامين C، انخفاض في Vitamin C
+
+520
+00:43:00,230 --> 00:43:05,640
+يؤدي إلى انخفاض في مستوى الإنزيم ALP، الـ
+
+521
+00:43:05,640 --> 00:43:10,220
+Principle of the Method ALP Enzyme، بسرعة نذهب
+
+522
+00:43:10,220 --> 00:43:14,820
+بفكرنا إلى أن العمل سيكون Kinetic، نأخذ أكثر من
+
+523
+00:43:14,820 --> 00:43:20,520
+Absorbance، سيتكون عندي مركب، نريد قياس معدل
+
+524
+00:43:20,520 --> 00:43:25,320
+تكوين هذا المركب مثلاً عند دقيقة، عند دقيقتين
+
+525
+00:43:25,320 --> 00:43:29,080
+عند ثلاث دقائق، وهذا كله سيعبر عن
+
+526
+00:43:29,080 --> 00:43:34,180
+activity الإنزيم، نقرأ الكالاين
+
+527
+00:43:34,180 --> 00:43:37,600
+فوسفاتيز، الـ ALP، الكالاين فوسفاتيز، الـ ALP
+
+528
+00:43:37,600 --> 00:43:37,960
+الكالاين فوسفاتيز، الـ ALP، الكالاين فوسفاتيز
+
+529
+00:43:37,960 --> 00:43:39,800
+الـ ALP، الكالاين فوسفاتيز، الـ ALP، الكالاين
+
+530
+00:43:39,800 --> 00:43:42,060
+فوسفاتيز، الـ ALP، الكالاين فوسفاتيز، الـ ALP
+
+531
+00:43:42,060 --> 00:43:46,520
+الكالاين فوسفاتيز، الـ ALP، الكالاين فوسفاتيز
+
+532
+00:43:46,520 --> 00:43:48,620
+الـ ALP، الكالاين فوسفاتيز، الـ ALP، الكالاين
+
+533
+00:43:48,620 --> 00:43:58,020
+فوسفاتيز، الـ ALP، الكالاين فوسفاتيز
+
+534
+00:43:58,020 --> 00:44:01,400
+الـ ALP، الـ Reagent  الذي يأتي من الشركة يكون
+
+535
+00:44:01,400 --> 00:44:06,240
+فيه substrate اسمها para nitro phenol phosphate، ويكون
+
+536
+00:44:06,240 --> 00:44:10,960
+أيضاً فيه magnésium كـ Co-factor يساعد على عمل
+
+537
+00:44:10,960 --> 00:44:15,420
+إنزيم ALP، تمام؟ وماء، هذه مكونات الـ Reagent
+
+538
+00:44:15,420 --> 00:44:19,120
+فلما نخلط الـ Reagent على العينة، الإنزيم
+
+539
+00:44:19,120 --> 00:44:23,320
+سيكسر الـ substrate ويعطيني الـ para nitro phenol و
+
+540
+00:44:23,320 --> 00:44:28,190
+فوسفات، فلما نجد أننا نريد قياساً حركياً،  أنا لا أريد
+
+541
+00:44:28,190 --> 00:44:32,110
+قياس شدة اللون، أعرف أن para nitrophenol هذه مادة
+
+542
+00:44:32,110 --> 00:44:37,730
+ملونة، لا أريد قياس لونها عند نقطة معينة، عند
+
+543
+00:44:37,730 --> 00:44:43,910
+نقطة معينة، لا، أريد قياس معدل تكوين para
+
+544
+00:44:43,910 --> 00:44:49,390
+nitrophenol عند دقيقة، ودقيقتين، وثلاث دقائق، وأربع
+
+545
+00:44:49,390 --> 00:44:55,000
+دقائق، وهذا التغير في معدل التكوين هو ما سيعبر
+
+546
+00:44:55,000 --> 00:45:00,340
+عن activity الإنزيم، نفس عمل الإنزيمات، لكن
+
+547
+00:45:00,340 --> 00:45:03,640
+الفرق أن في الإنزيمات السابقة، ماذا كان يتكون؟
+
+548
+00:45:03,640 --> 00:45:07,240
+الـ NADH، هذا المركب، لكن اليوم لدينا الـ
+
+549
+00:45:07,240 --> 00:45:11,320
+Paranitrophenol، يعني هنا لن يكون الطول الموجي 340
+
+550
+00:45:11,320 --> 00:45:16,230
+انتبهوا، لأن ليس NADH ما يتكون، يتكون مادة أخرى، The
+
+551
+00:45:16,230 --> 00:45:21,070
+Rate of Paranitrophenol Formation، معدل تكوين الـ
+
+552
+00:45:21,070 --> 00:45:27,130
+Paranitrophenol، نريد قياسه على الطيف، وهو
+
+553
+00:45:27,130 --> 00:45:32,430
+يتناسب طردياً مع تركيز ALP الموجود في
+
+554
+00:45:32,430 --> 00:45:37,310
+العينة، الإجراء يا جماعة نفس الإجراء
+
+555
+00:45:37,310 --> 00:45:42,190
+بالضبط، لـ من؟  لـ AST و ALT، شرحناها في
+
+556
+00:45:42,190 --> 00:45:48,010
+المختبر، أول شيء، ماذا نفعل؟ نأتي بأنابيب بلاستيكية
+
+557
+00:45:48,010 --> 00:45:53,710
+ونضعها في حمام مائي، تمام؟  نأخذ  الـ kit
+
+558
+00:45:53,710 --> 00:45:57,750
+لعمل ALP، فيه عاملين Reagent A و Reagent
+
+559
+00:45:57,750 --> 00:46:01,850
+B، نأخذ 800 ميكرولتر من Reagent A ونضعها
+
+560
+00:46:01,850 --> 00:46:06,490
+في الأنبوب، ثم نأتي بـ 20 ميكرولتر من المصل ونضعها
+
+561
+00:46:06,490 --> 00:46:11,770
+فوق الـ 800، ونعمل خلط جيد، طبعاً عملنا هذا كله على
+
+562
+00:46:11,770 --> 00:46:16,830
+حمام مائي درجة حرارته 37،  وبعد
+
+563
+00:46:16,830 --> 00:46:22,910
+خمس دقائق، نأتي بـ Reagent P، نأخذ منه 200 ميكرولتر ونضعها فوق الخليط
+
+564
+00:46:22,910 --> 00:46:28,210
+الذي أعددناه،  بمجرد وضع 200 ميكرولتر من
+
+565
+00:46:28,210 --> 00:46:33,790
+Reagent P، نشغل الساعة بسرعة، و
+
+566
+00:46:33,790 --> 00:46:39,810
+نأخذ هذا الخليط الموجود في الأنبوب، و
+
+567
+00:46:39,810 --> 00:46:44,650
+نضعه في الكيوفات، و نضع الكيوفات على الجهاز
+
+568
+00:46:44,650 --> 00:46:48,870
+ونقيس،  ونبدأ الحساب، نأخذ absorbance عند دقيقة
+
+569
+00:46:48,870 --> 00:46:53,850
+عند دقيقتين، عند ثلاث دقائق، عند أربع
+
+570
+00:46:53,850 --> 00:46:57,570
+دقائق، يعني نأخذ أربعة قياسات absorbance،  الجهاز يجب أن يكون
+
+571
+00:46:57,570 --> 00:47:02,570
+مضبوط على 405 نانومتر، نصفر على الماء المقطر
+
+572
+00:47:02,570 --> 00:47:08,050
+تمام؟ قبل أن أضع العينة في
+
+573
+00:47:08,050 --> 00:47:13,370
+الطيف، ويجب أن أكون قد صفرت على الماء، نأخذ أربعة
+
+574
+00:47:13,370 --> 00:47:17,590
+قياسات absorbance، والقراءة كما تعرفون، absorbance
+
+575
+00:47:17,590 --> 00:47:22,680
+الأول نطرحه من الثاني، والثاني من الثالث، والثالث من
+
+576
+00:47:22,680 --> 00:47:26,420
+الرابع،  يصبح لدينا ثلاث قيم absorbance، نأخذ متوسطها
+
+577
+00:47:26,420 --> 00:47:30,320
+نجمعهم ونقسمهم على ثلاثة، فالـ absorbance
+
+578
+00:47:30,320 --> 00:47:34,840
+الذي يظهر في النهاية نضربه في عامل الضرب
+
+579
+00:47:34,840 --> 00:47:39,960
+عامل الضرب يأتي مع الكتيب الخاص بالـ kit، تمام؟
+
+580
+00:47:39,960 --> 00:47:46,550
+عامل الضرب لـ ALP هو 2764، نضرب متوسط
+
+581
+00:47:46,550 --> 00:47:55,350
+absorbance الذي حصلنا عليه، نضربه
+
+582
+00:47:55,350 --> 00:47:58,670
+في هذا العامل، نحصل على تركيز الإنزيم بوحدة
+
+583
+00:48:02,850 --> 00:48:06,750
+international unit per liter، النطاق المرجعي
+
+584
+00:48:06,750 --> 00:48:11,330
+عند البالغين أعلى من 270 international unit per
+
+585
+00:48:11,330 --> 00:48:15,390
+liter، عند الأطفال أعلى من 800 international
+
+586
+00:48:15,390 --> 00:48:20,970
+unit per liter، أيضاً ALP أعلى عند الأطفال
+
+587
+00:48:20,970 --> 00:48:24,450
+أعلى من البالغين، لو سألناكم سؤال، لأن الأطفال في
+
+588
+00:48:24,450 --> 00:48:30,760
+مرحلة نمو عظامهم، العظام تتكون من نوعين من
+
+589
+00:48:30,760 --> 00:48:33,760
+الخلايا، غير موجودة  في محاضراتكم لكن علينا فهمها، Osteoblast
+
+590
+00:48:33,760 --> 00:48:37,860
+و Osteoclast، Osteoblast هذه الخلايا بناءة
+
+591
+00:48:37,860 --> 00:48:42,300
+للعظم، و Osteoclast هذه الخلايا هدامة للعظم، فلما
+
+592
+00:48:42,300 --> 00:48:46,600
+Osteoblast هذه الخلايا، بداخلها ALP
+
+593
+00:48:46,600 --> 00:48:51,340
+بداخلها الإنزيم، عند الأطفال يحتاجون... يعني
+
+594
+00:48:51,340 --> 00:48:56,100
+تكون نشطة أكثر، Osteoblast النشطة، الخلايا
+
+595
+00:48:56,100 --> 00:49:01,360
+البناءة للعظم، ما دام هناك بناء للعظم، ما دام هناك هذه
+
+596
+00:49:01,360 --> 00:49:04,880
+الخلايا تفرز هذا ALP، وبالتالي يزيد تركيزه
+
+597
+00:49:04,880 --> 00:49:09,380
+في الدم، لذلك عند الأطفال ALP يكون أعلى
+
+598
+00:49:09,950 --> 00:49:12,870
+وهكذا نكون قد أنهينا هذا الفصل، ويعطيكم العافية
+
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/u4q3JwIsRVo_postprocess.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/u4q3JwIsRVo_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..bcdfe8d2803c7aecd8ae1f9b3dc65043ffb88d46
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/u4q3JwIsRVo_postprocess.srt
@@ -0,0 +1,2396 @@
+1
+00:00:00,000 --> 00:00:05,180
+بدنا نحكي عن ال bone profile test الفحصات اللى
+
+2
+00:00:05,180 --> 00:00:11,260
+بتشيك على وضع العظام أول فحص هو ال calcium calcium
+
+3
+00:00:11,260 --> 00:00:16,760
+is required for cell function overall and for bone
+
+4
+00:00:16,760 --> 00:00:21,720
+metabolismapproximately 99% of body calcium is
+
+5
+00:00:21,720 --> 00:00:28,720
+found in ponds بيحكيلي إنه ال calcium مهم جدا لكل
+
+6
+00:00:28,720 --> 00:00:35,720
+الخلايا عشان تؤدي وظائفها أيضا مهم لبناء العظم
+
+7
+00:00:35,720 --> 00:00:42,060
+أصلا حكينا إن العظم هو المخزن تبع ال calciumتمام
+
+8
+00:00:42,060 --> 00:00:47,980
+فالكالسيوم هو المسؤول عن إعطاء ال rigidity للعظم
+
+9
+00:00:47,980 --> 00:00:52,580
+ليش العظام حكينا rigid صلبة من الأعطاها الصلابة
+
+10
+00:00:52,580 --> 00:00:58,980
+هذه وجود الكالسيوم فيها approximately 99% من ال
+
+11
+00:00:58,980 --> 00:01:02,940
+body calcium is found in bones يعني 99% من
+
+12
+00:01:02,940 --> 00:01:08,440
+الكالسيوماللي موجود جوات الجسم مخزن داخل العظام
+
+13
+00:01:08,440 --> 00:01:15,040
+واحد في المية فقط هو اللي موجود في بلازما الدم،
+
+14
+00:01:15,040 --> 00:01:42,840
+تمام؟الكالسيوم موجود في الدم في شكلين
+
+15
+00:01:47,170 --> 00:01:53,650
+تمام؟ حر مش مربوط بأي إشي وهو هذا الشكل ال active
+
+16
+00:01:53,650 --> 00:01:57,670
+بما أنه مش مربوط معناه هو اللي بيروح للخلايا،
+
+17
+00:01:57,670 --> 00:02:03,150
+بدخللها عشان تؤدي وظائفها، بتطلع منها، فهو يعني هو
+
+18
+00:02:03,150 --> 00:02:07,470
+ال free هو ال active form أو بنسميه ال ionized
+
+19
+00:02:07,470 --> 00:02:16,820
+formالمتأين المشحون تمام and the other و 55% من
+
+20
+00:02:16,820 --> 00:02:22,240
+الكالسيوم اللي موجود في البلازمة هو bound كالسيوم
+
+21
+00:02:22,240 --> 00:02:26,400
+مرتبط و على الأغلب بيكون مرتبط ببروتين و نوع هذا
+
+22
+00:02:26,400 --> 00:02:31,800
+البروتين هو ال albumin إذاً 45% من الكالسيوم free
+
+23
+00:02:31,800 --> 00:02:38,040
+و 55%من الكالسيوم اللي موجود في بلاذ مادة بيكون
+
+24
+00:02:38,040 --> 00:02:42,960
+مرتبط ببروتين اسمه الـ albumin وهذا المرتبط عادة
+
+25
+00:02:42,960 --> 00:02:49,180
+ما بيكون مشحون تمام؟ لأن شحنته اتعدلت مثلا هو كان
+
+26
+00:02:49,180 --> 00:02:53,160
+موجب وال albumin سالب ربطوا في بعض وبالتالي بطل
+
+27
+00:02:53,160 --> 00:02:58,040
+مشحون inactive form يعني بما انه ارتبط معناه مش
+
+28
+00:02:58,040 --> 00:03:04,650
+هيقدر يؤدي وظيفتهبنسميه الـ Bound أو الـ Inactive
+
+29
+00:03:04,650 --> 00:03:12,760
+Form الـ Form اللي مش نشطهذا الـ slide كتير مهمة
+
+30
+00:03:12,760 --> 00:03:17,340
+too little calcium gets you either a loss of
+
+31
+00:03:17,340 --> 00:03:22,140
+tissue function or soft ponds osteoporosis بيقصد
+
+32
+00:03:22,140 --> 00:03:28,320
+فيها لو كانت نسبة الكالسيوم جواة العظم كانت قليلة
+
+33
+00:03:28,320 --> 00:03:35,390
+هذا هيؤدي إلىإحداث الـ Soft Bones هتصبح العظام هشة
+
+34
+00:03:35,390 --> 00:03:40,770
+سهلة الكثر يعني بيصير عندي osteoporesis هشاشة عظام
+
+35
+00:03:40,770 --> 00:03:45,650
+وهذه حالة مرضية طبعا إذا في حال نقص الكالسيوم في
+
+36
+00:03:45,650 --> 00:03:49,450
+المخزن يعني نقص مستوى الكالسيوم في الـ bones في
+
+37
+00:03:49,450 --> 00:03:53,030
+العظام اتفاجن الكالسيوم هو اللي يعطي الـrigidity
+
+38
+00:03:53,030 --> 00:03:58,880
+الصلابة للعظم فلو نقص الكالسيوم هتصبح العظامسهلة
+
+39
+00:03:58,880 --> 00:04:04,660
+الكسر soft bone عظام ناعمة وهشة osteoporosis حالة
+
+40
+00:04:04,660 --> 00:04:11,090
+مرضية نقصد فيها هشاشة عظامwhile too much gives you
+
+41
+00:04:11,090 --> 00:04:16,630
+titanic cardiac arrest and or lockjaw is from over
+
+42
+00:04:16,630 --> 00:04:21,290
+clinching of muscles or over brittle bones إيش
+
+43
+00:04:21,290 --> 00:04:26,170
+بيقصد في الشق الآخر؟ الشق الآخر عكس الأول الشق
+
+44
+00:04:26,170 --> 00:04:32,250
+الآخر بيحكي لو مستوى الكالسيوم كان في ال bonesأعلى
+
+45
+00:04:32,250 --> 00:04:37,370
+من الحد المسموح يعني عالي كتير كتير احنا حكينا هو
+
+46
+00:04:37,370 --> 00:04:41,270
+موجود بكميات كبيرة في ال bones ولكن لو زاد عن هذه
+
+47
+00:04:41,270 --> 00:04:48,910
+الكميات هيؤدي ذلك إلى تصلب العظم يعني العظم يعني
+
+48
+00:04:48,910 --> 00:04:54,170
+على الرغم من انه rigid صلب لكن مرن بتحرك لكن في
+
+49
+00:04:54,170 --> 00:05:00,380
+حالزاد مستوى الكالسيوم وكان أكتر من الطبيعي جوات
+
+50
+00:05:00,380 --> 00:05:04,860
+الـ Bones راح يؤدي إلى التتاناص حيصاب الشخص
+
+51
+00:05:04,860 --> 00:05:09,420
+بتتاناص في عضلاته ممكن يصير عنده cardiac arrest
+
+52
+00:05:09,420 --> 00:05:16,220
+توقف عضلة القلب نتيجة ارتفاع مستوى الكالسيوم ممكن
+
+53
+00:05:16,220 --> 00:05:24,430
+يصير عنده lock jaw يعنيفك أثنانه بيبطل يتحرك اللي
+
+54
+00:05:24,430 --> 00:05:29,770
+هو مرض الكزاز بنحكي عنه الـ Tetanus هذا كله إيش
+
+55
+00:05:29,770 --> 00:05:34,290
+سببه؟ is from over clinching of muscles هذا سببه
+
+56
+00:05:34,290 --> 00:05:43,930
+إن العضلات يعني صار فيهاانقباض مستمر وجهدات العظام
+
+57
+00:05:43,930 --> 00:05:47,890
+والعضلات تفاجنا إنه لما بتكون الـ Calcium أعلى من
+
+58
+00:05:47,890 --> 00:05:52,310
+الحد الطبيعي في الـ Bones بتصير العضلة يعني خلاص
+
+59
+00:05:52,310 --> 00:05:57,270
+مش جادرة تتحرك رجد كتير، ثلبة كتير كتير ممكن الشخص
+
+60
+00:05:57,270 --> 00:06:03,110
+يصير عنده الـ Titanus نتيجة الانقباض المستمر
+
+61
+00:06:03,110 --> 00:06:10,380
+للعضلة ويعني انقباض فوق الطبيعيطبعا هذا المقصود
+
+62
+00:06:10,380 --> 00:06:13,800
+إذا من هذه الفقرة بتفهم شغلتان لو جال مستوى ال
+
+63
+00:06:13,800 --> 00:06:19,740
+calcium في العضم العضم بيصير هش بنكسر لكن بيصير
+
+64
+00:06:19,740 --> 00:06:24,860
+عندي osteoporosis هشاشة عضان لكن لو ال calcium زاد
+
+65
+00:06:24,860 --> 00:06:30,260
+مستوى في العضم أكتر من الطبيعي بيصير عندي تشنش في
+
+66
+00:06:30,260 --> 00:06:34,900
+العضم بيصير عندي تيتانوس يصاب الشخص بالتيتانوس
+
+67
+00:06:34,900 --> 00:06:41,270
+طبعا okayChains in calcium are used to assess bond
+
+68
+00:06:41,270 --> 00:06:47,850
+function أي تغير في مستوى الكالسيوم هذا مهم جدا
+
+69
+00:06:47,850 --> 00:06:53,680
+وبيعبر عن وظيفة الـ bondHigher blood levels
+
+70
+00:06:53,680 --> 00:06:59,500
+usually mean lower bone levels بيحكيلي عادة لو كان
+
+71
+00:06:59,500 --> 00:07:04,880
+مستوى الكالسيوم في الدم عالي عالي كتير أعلى من
+
+72
+00:07:04,880 --> 00:07:09,720
+الطبيعي هذا بيعبر أن مستوى الكالسيوم في ال bone
+
+73
+00:07:09,720 --> 00:07:17,020
+بدأ يقل أو حيقل تمام؟Usually performed in
+
+74
+00:07:17,020 --> 00:07:20,600
+conjugation with phosphorus determination عادة ما
+
+75
+00:07:20,600 --> 00:07:24,400
+بنعمل فحص الكالسوم لحاله دايما كالسوم و فوسفورس مع
+
+76
+00:07:24,400 --> 00:07:29,400
+بعض عشان نشيك على وضع الـBond Three hormones،
+
+77
+00:07:29,400 --> 00:07:33,900
+تلاتة هرمونات الـparathyroid hormone هرمونات
+
+78
+00:07:33,900 --> 00:07:39,150
+الغضدجاردرقيةVitamin DL والـ Calcitonin هذا
+
+79
+00:07:39,150 --> 00:07:42,570
+الهرمون بتتم إفرازه من الغدة الدراقية نفسها من الـ
+
+80
+00:07:42,570 --> 00:07:46,490
+thyroid gland are known to regulate serum calcium
+
+81
+00:07:46,490 --> 00:07:50,230
+by altering their secretion rate in response to
+
+82
+00:07:50,230 --> 00:07:54,910
+changes in ionized calcium، تلت هرمونات مسئولة عن
+
+83
+00:07:54,910 --> 00:08:01,110
+تنظيم مستوىالـ Ionized Calcium للـ Free Form
+
+84
+00:08:01,110 --> 00:08:05,990
+كالسيوم في الدم تمام هم اللي بنظموا مستوى ال
+
+85
+00:08:05,990 --> 00:08:09,870
+Ionized Calcium في الدم و هنشوف ال ميكانيزم كيف
+
+86
+00:08:11,380 --> 00:08:18,100
+الركز مع بعض من الرسمة بيحكيلي لما مستوى الـ
+
+87
+00:08:18,100 --> 00:08:21,500
+Ionized Calcium أنا بهمنه الـ Free Calcium يا
+
+88
+00:08:21,500 --> 00:08:26,000
+جماعة لأن هو اللي بيقدّي الوظيفة في الجسم الـ Free
+
+89
+00:08:26,000 --> 00:08:31,000
+Calcium اللي في البلازمة تبعت الدم لما بيقل مستوى
+
+90
+00:08:31,000 --> 00:08:40,710
+الـ Ionized Calcium في بلازمة الدم هذا إشارةلا الـ
+
+91
+00:08:40,710 --> 00:08:45,710
+Parathyroid gland إنها تقوم بإفراز الـ Parathyroid
+
+92
+00:08:45,710 --> 00:08:49,730
+hormone إذن الـ Parathyroid gland الغُدّ
+
+93
+00:08:49,730 --> 00:08:54,170
+الجاردرقية تستشعر في إنه في نقص في الـ Ionized
+
+94
+00:08:54,170 --> 00:08:59,010
+calcium في بلازمة الدم فبتقوم بإفراز هرمون اسمه
+
+95
+00:08:59,010 --> 00:09:03,570
+الـ Parathyroid hormone هذا لما بيتم إفرازه لو
+
+96
+00:09:03,570 --> 00:09:09,320
+تبعته على الصورةلما بيتم إفرازه إلى two-receptor
+
+97
+00:09:09,320 --> 00:09:13,680
+بيشتغل يعني على ممتقتين أو على أدوين في الجسم هذا
+
+98
+00:09:13,680 --> 00:09:20,100
+الهورمون بيروح بيشتغل على الـ bone على العظم
+
+99
+00:09:20,100 --> 00:09:26,110
+وبيحفظالـ Calcium اللي موجود في الـ bone إنه يطلع
+
+100
+00:09:26,110 --> 00:09:31,710
+لبرا يطلع على الدم يعني من المخزن للدم عشان يزيد
+
+101
+00:09:31,710 --> 00:09:35,890
+مستوى الـ Ionized Calcium إذن أول شغل للـ
+
+102
+00:09:35,890 --> 00:09:41,190
+Parathyroid hormone إنها بتروح على الـ bone لأنه
+
+103
+00:09:41,190 --> 00:09:44,850
+هو المخزن للكالسيوم وأنا بحاجة في الدم للكالسيوم
+
+104
+00:09:44,850 --> 00:09:50,430
+وبيصير الـ bone يطلع كالسيوم من عنده إلى إبلازمة
+
+105
+00:09:50,430 --> 00:09:56,870
+الدم، تمام؟وال action التاني .. الشغل التاني للـ
+
+106
+00:09:56,870 --> 00:10:00,530
+Parathyroid hormone أنه بيروح على الكلا
+
+107
+00:10:03,030 --> 00:10:08,430
+بحفظ الكيلة إنها تعمل Reabsorption للكالسيون،
+
+108
+00:10:08,430 --> 00:10:11,410
+الكيلة وظّفتها تطلّع الشغلات اللي بدنا نشيها و
+
+109
+00:10:11,410 --> 00:10:15,350
+ترجع الشغلات اللي بدّيها، فهو بحفظ الكيلة تعمل
+
+110
+00:10:15,350 --> 00:10:20,730
+إعادة انتصاص للـIonized Calcium وترجعه إلى البلازم
+
+111
+00:10:20,730 --> 00:10:24,170
+الدم لأنه أنا بدياه، لأنه فعليا الشخص هذا صار عنده
+
+112
+00:10:24,170 --> 00:10:29,180
+نقص في الـIonized Calciumمش بس هيك الكيلة بتعمل
+
+113
+00:10:29,180 --> 00:10:34,020
+أيضًا الـ Parathyroid hormone بحفظ الكيلة إنها
+
+114
+00:10:34,020 --> 00:10:39,800
+تكمل .. اتكمل في تصنيع Vitamin Dالتفاجنة إنه
+
+115
+00:10:39,800 --> 00:10:44,400
+Vitamin Dال بتصنع في ال liver وبيتم اكمال تصنيعه
+
+116
+00:10:44,400 --> 00:10:48,430
+في ال kidney في الكبت صح ولا لأ؟في الـ kidney، في
+
+117
+00:10:48,430 --> 00:10:53,070
+الكلة، صح ولا لأ؟ إذن الـ Parathyroid hormone كمان
+
+118
+00:10:53,070 --> 00:10:58,550
+بتحفظ الكلة إنها تكمل تصنيع Vitamin DL إذن Vitamin
+
+119
+00:10:58,550 --> 00:11:04,490
+DL اتصنع و تمام و صار active Vitamin DL إيش بيعمل؟
+
+120
+00:11:04,490 --> 00:11:12,000
+Vitamin DL بيحفظ إعادة انتصاف الكالسيومعبر الـ
+
+121
+00:11:12,000 --> 00:11:17,960
+intestine تمام؟ بمنع ال calcium يخرج مع ال stool
+
+122
+00:11:17,960 --> 00:11:24,560
+صح ولا لا؟ فبحفظ ال vitamin D بشتغل على ال
+
+123
+00:11:24,560 --> 00:11:30,060
+intestine الأمعاءوبيحفظ الأمعاء تعمل Reabsorption
+
+124
+00:11:30,060 --> 00:11:35,140
+للكالسيوم تعمله إعادة انتصاص و ترجعه للدم ومايخرجش
+
+125
+00:11:35,140 --> 00:11:38,620
+مع ال stool أنا ما بدي أعمل Execration له بالعكس
+
+126
+00:11:38,620 --> 00:11:42,480
+الدم ال ionized calcium فيه قليل فانا بدي أرجعه
+
+127
+00:11:42,480 --> 00:11:48,960
+للدم تمام؟ إذا هذه كل ال mechanism هذا عشان أذود
+
+128
+00:11:48,960 --> 00:11:52,840
+مستوى ال ionized calcium في الدم تمام؟
+
+129
+00:11:57,180 --> 00:12:04,560
+أما الشق الأخرفي حال ارتفع الـ ionized calcium
+
+130
+00:12:04,560 --> 00:12:08,160
+عندى فى الدم ارتفع عن الوضع الطبيعى الإنسان
+
+131
+00:12:08,160 --> 00:12:11,640
+الطبيعى لازم يكون ضمن range معين ال calcium عنده
+
+132
+00:12:11,640 --> 00:12:15,360
+ال ionized calcium فلو انخفط حكينا ايش بيصير مين
+
+133
+00:12:15,360 --> 00:12:19,960
+بيشتغل الـ parathyroid hormone لكن لو ارتفع مستوى
+
+134
+00:12:19,960 --> 00:12:24,060
+ال ionized calcium فى الدم انا بدي مين ينزله تمام
+
+135
+00:12:24,060 --> 00:12:30,090
+فالشق الاخر بيحكي لي لو ارتفعمستوى الـ Ionized
+
+136
+00:12:30,090 --> 00:12:38,130
+كالسيوم في الدم مين هيشتغل؟ لما بيرتفع اللي هيتحسس
+
+137
+00:12:38,130 --> 00:12:41,950
+بهذا الارتفاع الـ Thyroid gland الغضب الدراقية
+
+138
+00:12:41,950 --> 00:12:47,910
+نفسها وتقوم بإفراز الـ Calcitonin هذا هرمون يفرز
+
+139
+00:12:47,910 --> 00:12:51,610
+من الغضب الدراقية برضه يا جماعة الـ Calcitonin
+
+140
+00:12:51,610 --> 00:12:56,530
+بشتغل على موقعين زي و زي الـ Parathyroid hormone
+
+141
+00:12:57,460 --> 00:13:03,100
+بشتغل على العظم وبشتغل على الـ kidneyبشتغل على
+
+142
+00:13:03,100 --> 00:13:07,100
+العضم وإيش بيحفظ زي ما هو مكتوب بالـ slide
+
+143
+00:13:07,100 --> 00:13:12,460
+Simulates calcium deposition in bones يمنع خروج
+
+144
+00:13:12,460 --> 00:13:18,020
+الكالسيوم من الـ bone للدم لأن الدم أصلا مليان
+
+145
+00:13:18,020 --> 00:13:23,360
+ionized calcium فبديش ionized calcium بزيادة فبمنع
+
+146
+00:13:23,360 --> 00:13:27,100
+بحفظ الـ deposition للكالسيوم يعني بيخلي الكالسيوم
+
+147
+00:13:27,100 --> 00:13:31,360
+في الـ bone وممنوع يطلع للدمعكس شغل الـ
+
+148
+00:13:31,360 --> 00:13:36,220
+Parathyroid hormone إذا منتبهين و أيضًا بيشتغل الـ
+
+149
+00:13:36,220 --> 00:13:40,340
+Calcitonin على الـ kidney و إيش بيعمل للـ kidney؟
+
+150
+00:13:40,340 --> 00:13:45,920
+و بيحفظ الكيلة تعمل Execration للكالسيوم بحفظ
+
+151
+00:13:45,920 --> 00:13:49,960
+للكيلة تتخلص من الكالسيوم عن طريق الـ urine و
+
+152
+00:13:49,960 --> 00:13:54,240
+ممنوع تعمله Reabsorption و بهيك ترجع مستوى الـ
+
+153
+00:13:54,240 --> 00:13:58,680
+Ionized Calcium في الدم طبيعيتمام؟ إذا اللي بنظّم
+
+154
+00:13:58,680 --> 00:14:02,460
+مستوى الكالسيوم في الدم البارا تايرويد هرمون
+
+155
+00:14:02,460 --> 00:14:07,580
+هرمونات الغدة الجاردراقية و الـ Calcitonin اللي
+
+156
+00:14:07,580 --> 00:14:11,460
+بيفرز من الغدة الدراقية و برضه vitamin ده العبارة
+
+157
+00:14:11,460 --> 00:14:18,340
+عن هرمون في الآخر صنفه برضه مسئول عن تنظيم مستوى
+
+158
+00:14:18,340 --> 00:14:22,740
+الكالسيوم في الدم تمام؟ إذا هذه تلت هرمونات بتنظم
+
+159
+00:14:22,740 --> 00:14:27,190
+مستوى الكالسيوم في الدمالـ Principle of the Method
+
+160
+00:14:27,190 --> 00:14:31,650
+مبدأ طريقتنا Calorimetric Reaction الكالسيوم بروح
+
+161
+00:14:31,650 --> 00:14:35,870
+يتفاعل مع مادة موجودة في الـReagent محصلة التفاعل
+
+162
+00:14:35,870 --> 00:14:39,530
+اعطاء مادة ملونة بالقيس شدة هاد المادة
+
+163
+00:14:39,530 --> 00:14:44,800
+والـabsorbance تبعها على جهاز الـSpectraمقارنة
+
+164
+00:14:44,800 --> 00:14:48,940
+الكالسيوم في المجلد تعتمد على صناعة مجلد ألوان
+
+165
+00:14:48,940 --> 00:14:54,100
+كمplex بين كالسيوم و أورثو كريزوفاتالين في مجلد
+
+166
+00:14:54,100 --> 00:14:57,620
+ألكولايين ميديا ري أجينت اللي بيجي من الشركة يحتوي
+
+167
+00:14:57,620 --> 00:15:01,620
+على مادة الأورثوالـ Chrysophthalene هذه اللي
+
+168
+00:15:01,620 --> 00:15:06,220
+بتتفاعل مع الكالسيوم الـ alkaline pH يعني ال
+
+169
+00:15:06,220 --> 00:15:12,040
+reaction بتكون ال pH تبعته alkaline محصلة التفاعل
+
+170
+00:15:12,040 --> 00:15:17,920
+colored complex مادة املونة و عادة اللون اللي بظهر
+
+171
+00:15:17,920 --> 00:15:22,270
+من التفاعل لونه violet بنفس جهةالـ Ortho
+
+172
+00:15:22,270 --> 00:15:26,510
+-chrysophthalene complex one gives violet color in
+
+173
+00:15:26,510 --> 00:15:29,810
+alkaline medium في الآخر اتحاد الكالسيوم مع هذه
+
+174
+00:15:29,810 --> 00:15:34,310
+المادة باعطين اللون الـ violet the intensity of
+
+175
+00:15:34,310 --> 00:15:37,790
+the color formed is proportional to the calcium
+
+176
+00:15:37,790 --> 00:15:43,240
+concentration in the sample شدة اللونتتناسب تناسب
+
+177
+00:15:43,240 --> 00:15:48,700
+ترضي مع تركيز الكالسيوم في العينة كمان شغلة ال kit
+
+178
+00:15:48,700 --> 00:15:53,560
+اللي عندي في المختبر بيقيث ال total calcium يعني
+
+179
+00:15:53,560 --> 00:15:56,740
+إيش يعني total calcium؟ يعني بيقيث ال total
+
+180
+00:15:56,740 --> 00:16:00,220
+calcium في ال plasma الدم يعني بيقيث ال free
+
+181
+00:16:00,220 --> 00:16:05,640
+calcium plus ال bound calcium يعني بيقيث كل
+
+182
+00:16:05,640 --> 00:16:11,040
+الكالسيوم سواء المرتبط أو الغير مرتبطأيضاً في
+
+183
+00:16:11,040 --> 00:16:16,500
+عيننا كتات بتقيث فقط الـ Ionized Calcium الجزء الـ
+
+184
+00:16:16,500 --> 00:16:19,580
+Free الكالسيوم الحر تمام؟ هذه الشيءة بدنا ناخدها
+
+185
+00:16:19,580 --> 00:16:26,380
+بعين الاعتبار ال
+
+186
+00:16:26,380 --> 00:16:31,080
+specimen العينة لو بدنا نفحص ال total calcium أو
+
+187
+00:16:31,080 --> 00:16:36,200
+ال ionized calciumالعينة Serum أو Heparinized
+
+188
+00:16:36,200 --> 00:16:39,920
+Plasma أو 24 Hours Urine لأنه حكينا الـ Calcium
+
+189
+00:16:39,920 --> 00:16:44,400
+ممكن يصير له Execration مع الـ urine تمام عن طريق
+
+190
+00:16:44,400 --> 00:16:49,040
+الكدنىSeparation from cells are rapidly as
+
+191
+00:16:49,040 --> 00:16:51,880
+possible to avoid the uptake of calcium by
+
+192
+00:16:51,880 --> 00:16:55,980
+erythrocyte يعني هذه الجملة خلاص فهمناها ال
+
+193
+00:16:55,980 --> 00:16:59,660
+calcium زي و زي السكر يعني لما بتصلني العينة بسرعة
+
+194
+00:16:59,660 --> 00:17:04,320
+بدي أفصل ال serum عن خلايا الدم الحامرة لأنه لو
+
+195
+00:17:04,320 --> 00:17:08,320
+دلهم contact مع بعض هتصير خلايا الدم الحامرة تسحب
+
+196
+00:17:08,320 --> 00:17:11,160
+في ال calcium شوي شوي زي ما كانت تتسحب في السكر
+
+197
+00:17:11,160 --> 00:17:15,630
+لأنه خلايا بتقوم بأعماليات حيويةفتحتاج الكالسيوم
+
+198
+00:17:15,630 --> 00:17:19,790
+في عملياتها فهتظلها تصحي بالكالسيوم وهذا الأمر
+
+199
+00:17:19,790 --> 00:17:24,030
+مرفوض يعني بسرعة بدنا ن center العينة ونفصل الـ
+
+200
+00:17:24,030 --> 00:17:30,070
+Serum عن خلايا الدم الحمرةVenus Stasis هذا المصطلح
+
+201
+00:17:30,070 --> 00:17:34,090
+أخدناه قبل هيك تعريفه prolong tourniquet
+
+202
+00:17:34,090 --> 00:17:38,690
+application إنك تبقى رابط المربط اللي هو
+
+203
+00:17:38,690 --> 00:17:42,510
+tourniquet قبل ما تيجي تسحب الدم لفترة طويلة يعني
+
+204
+00:17:42,510 --> 00:17:46,590
+أربط ال tourniquet و بعدين أحضر أدواتي هذا الأمر
+
+205
+00:17:46,590 --> 00:17:52,080
+أكيد مرفوض طيب لو أنت عملت هيك إيش هيصير؟and
+
+206
+00:17:52,080 --> 00:17:57,200
+forearm exercise يعني لو انت طولت وانت رابط ال
+
+207
+00:17:57,200 --> 00:18:02,400
+tourniquet هاي شغلة ومش بس هيك لو الشخص كان مثلا
+
+208
+00:18:02,400 --> 00:18:07,740
+عامل مجهود عضلي في إيده اللي بدي يسحب منها جاب
+
+209
+00:18:07,740 --> 00:18:12,060
+العملية السحب يعني مجهد عضلات الإيد كلها هذه
+
+210
+00:18:12,060 --> 00:18:16,720
+الشغلات إيش ممكن تسوي؟ هتعمل زيادة في ال ionized
+
+211
+00:18:16,720 --> 00:18:22,680
+calcium ليش؟هل جيت إجهاد العضلة أو ربط الـ
+
+212
+00:18:22,680 --> 00:18:25,680
+tourniquet ما نفس الأشياء انت اما تربطي تربط ال
+
+213
+00:18:25,680 --> 00:18:31,020
+tourniquet فترة طويلة على الإيد هيصير في إجهاد
+
+214
+00:18:31,020 --> 00:18:36,520
+العضلات هتجهد، هتتعب، تمام؟ هذا التعب هيؤدي إلى
+
+215
+00:18:36,520 --> 00:18:41,760
+خفض الـ pH تبع الدم كلنا عارفين أن الـ pH تبع الدم
+
+216
+00:18:41,760 --> 00:18:49,040
+عند الإنسان الطبيعي إنيوترال من 7.3 ل7.4، تمام؟لكن
+
+217
+00:18:49,040 --> 00:18:53,700
+في حال إنسان عمل مجهود عضلي زيادة عن اللزوم سواء
+
+218
+00:18:53,700 --> 00:18:56,760
+في عضلات الجسم كلها أو هنا بيحكي عن عضلة الإيد
+
+219
+00:18:56,760 --> 00:19:00,740
+اللي بنسحب منها أو ربطنة تورنكت وبالتالي تورنكت
+
+220
+00:19:00,740 --> 00:19:06,760
+هيأثر على عضلات الإيد طيبهذه الشغلات إيش هتعمل
+
+221
+00:19:06,760 --> 00:19:11,820
+بيحكيلي هتخفض مستوى الـ pH في الدم بدل ما يكون
+
+222
+00:19:11,820 --> 00:19:17,080
+neutral متعادل ممكن يصير بما إنه هيتخفض الـ pH
+
+223
+00:19:17,080 --> 00:19:23,280
+ممكن يصير acidic pH وهذه حالة مرضية ليش؟ لأنه إذا
+
+224
+00:19:23,280 --> 00:19:28,360
+أخدتوها بالحيوية لما نجهد العضلة أو نشتغل مجهود في
+
+225
+00:19:28,360 --> 00:19:35,360
+مجهود عضلي جبار بتتكون مادة الـ lactic acidأو الـ
+
+226
+00:19:35,360 --> 00:19:40,120
+Lactic Acid أو الـ Lactate صح ولا لأ؟ هذه المادة
+
+227
+00:19:40,120 --> 00:19:45,420
+تتكون بكميات أكبر من الطبيعي إذا انت عملت مجهود
+
+228
+00:19:45,420 --> 00:19:49,740
+عضلي وجود هذه المادة، دي مادة حنضية وجودها في الدم
+
+229
+00:19:49,740 --> 00:19:55,440
+already هيخفض من مستوى الـ pH بسرعة بتأثر على
+
+230
+00:19:55,440 --> 00:20:00,390
+مستوى الـ pH الـ pH هيكون neutralلو انت عملت مجهود
+
+231
+00:20:00,390 --> 00:20:05,090
+عضلي هتتكون مادة اسمها الـ Lactic Acid هذه المادة
+
+232
+00:20:05,090 --> 00:20:10,430
+الحنضية هتخفض مستوى الـ pH ويصير الـ pH أثدك تمام؟
+
+233
+00:20:11,610 --> 00:20:18,110
+ولمّا يصير الـ pH أثيدك بيحكيلي هذا بيزود مستوى ال
+
+234
+00:20:18,110 --> 00:20:23,610
+ionized calcium في الدم إذا الـ venous stasis ربط
+
+235
+00:20:23,610 --> 00:20:27,630
+التورنيكات فترة طويلة ال forearm exercise عمل
+
+236
+00:20:27,630 --> 00:20:31,810
+مجهود كل هذه الشغلات هتزود مستوى ال ionized
+
+237
+00:20:31,810 --> 00:20:37,080
+calcium بشكل خاطئ في الدم إيش السبب؟صار في عندي
+
+238
+00:20:37,080 --> 00:20:43,540
+decrease in pH قلي الـ pH تبع الدم ليش؟ بسبب إنتاج
+
+239
+00:20:43,540 --> 00:20:48,340
+الـ Lactic Acid في العضلة في العضلة بيصير نتيجة
+
+240
+00:20:48,340 --> 00:20:54,420
+إجهادها بتتكون مادة حنضية اسمها الـ Lactic Acid هي
+
+241
+00:20:54,420 --> 00:20:59,380
+اللي بتنزل الـ pH وبالتالي هذا بيؤدي إلى رفع مستوى
+
+242
+00:20:59,380 --> 00:21:03,880
+الـ Ionized Calcium في الدم واضح؟ هذه شغلات بدنا
+
+243
+00:21:03,880 --> 00:21:09,190
+نتجنبهاExposing the sample to air will cause an
+
+244
+00:21:09,190 --> 00:21:13,570
+increase in pH إن العكس بيحكي لي لو سحبت عينة من
+
+245
+00:21:13,570 --> 00:21:19,810
+شخص وعربت العينة لـair لهوة لفترة طويلة يعني دايما
+
+246
+00:21:19,810 --> 00:21:26,290
+بدنا نسكر ال tube تبعت السحب لو عربت ال sample
+
+247
+00:21:26,290 --> 00:21:32,520
+للهوة معناه في oxygen أكتر من الـCO2الـ Oxygen
+
+248
+00:21:32,520 --> 00:21:40,500
+هيزيد الـ CO2 هيجل هذا كله هيزود مستوى الـ pH ليش؟
+
+249
+00:21:40,500 --> 00:21:45,200
+لأنه بيحكيلي هينخفض مستوى الـ CO2 والـ Oxygen
+
+250
+00:21:45,200 --> 00:21:49,360
+هيزيد وبالتالي هذا كله هذا ال reaction كله هيزود
+
+251
+00:21:49,360 --> 00:21:54,960
+الـ pH يعني الـ pH تبع الدم هيصير تبع العينة هيصير
+
+252
+00:21:54,960 --> 00:22:01,370
+alkalineمش neutral ولمّا بيصير الدم alkaline ال
+
+253
+00:22:01,370 --> 00:22:05,310
+ionized calcium begin إذا نطلع من هذا ال slide
+
+254
+00:22:05,310 --> 00:22:09,950
+بشغلتين في حال كان ال pH تبع الدم عند الإنسان
+
+255
+00:22:09,950 --> 00:22:13,590
+الطبيعي in neutral متعدل هذا المقلوب مستوى ال
+
+256
+00:22:13,590 --> 00:22:19,030
+ionized calcium بيكون طبيعي لكنلو انخفض الـ pH
+
+257
+00:22:19,030 --> 00:22:22,610
+يعني صار الـ pH أسدك وهذه حالة مرضية أي إنسان
+
+258
+00:22:22,610 --> 00:22:26,410
+بيكون عنده الـ pH تبع الدم أسدك حالة مرضية صعبة
+
+259
+00:22:26,410 --> 00:22:33,090
+لما بيصير الدم أسدك الـ ionized calcium بيزيد لما
+
+260
+00:22:33,090 --> 00:22:38,930
+بيصير الدم alkaline يعني الـ pH عالية ال ionized
+
+261
+00:22:38,930 --> 00:22:42,370
+calcium مستوى في الدم بيجل تمام؟
+
+262
+00:22:46,300 --> 00:22:51,960
+طبعا الـ Normal Range للكالسيوم عند الـ Normal
+
+263
+00:22:51,960 --> 00:22:55,560
+Range هنا قصده الـ Total Calcium انتبهوا الـ
+
+264
+00:22:55,560 --> 00:22:59,700
+Normal Range لـ Total Calcium الـ Ionized ذائد الـ
+
+265
+00:22:59,700 --> 00:23:05,440
+Bound عند الـ Adult من 8.5 ل 10.5 milligram per
+
+266
+00:23:05,440 --> 00:23:09,040
+deciliter فححوا اللي عندكم، عندكم بالـ slide مكتوب
+
+267
+00:23:09,040 --> 00:23:13,440
+microgram، No الكالسيوم بتم قياسه بالmilligram per
+
+268
+00:23:13,440 --> 00:23:18,900
+deciliterعند ال children من عشرة لاطنعش milligram
+
+269
+00:23:18,900 --> 00:23:23,340
+per DC لتر ملاحظين أعلى من ال adult مستوى ال total
+
+270
+00:23:23,340 --> 00:23:27,420
+calcium عندهم لأنه أصلا لازم يكون عندهم عالي عشان
+
+271
+00:23:27,420 --> 00:23:31,640
+جسمهم يبني عشان العضم عندهم ينبنع فبدهم calcium
+
+272
+00:23:31,640 --> 00:23:36,960
+أكتر تمام؟ لو بدي أحولها بال micro mole per liter
+
+273
+00:23:36,960 --> 00:23:43,660
+زي ما احنا شايفينحالات بيصير فيها hypocalcemia
+
+274
+00:23:43,660 --> 00:23:49,340
+يعني انخفاض مستوى هنا بيقصد الـ ionized calcium في
+
+275
+00:23:49,340 --> 00:23:53,360
+الدم الـ hypocalcemia معناه في عندي انخفاض في
+
+276
+00:23:53,360 --> 00:23:58,240
+مستوى ال ionized calcium في الدم متى بيصير هذا؟
+
+277
+00:23:58,880 --> 00:24:02,960
+بيصير عندما يكون عندى vitamin Dالـdeficiency لو
+
+278
+00:24:02,960 --> 00:24:06,420
+عندى تفاجنا vitamin Dالإيش بيعمل؟ هو اللى بيحفظ
+
+279
+00:24:06,420 --> 00:24:11,360
+الأمعاق تعمل إعادة انتصاص للكالسوم وتمنع خروجه عبر
+
+280
+00:24:11,360 --> 00:24:15,540
+الستول فلو مافيشش vitamin Dالمعناه الكالسوم
+
+281
+00:24:15,540 --> 00:24:21,220
+هيصيرله خروج مع الستول ويقل مستوى معناه هيصير عندى
+
+282
+00:24:21,220 --> 00:24:26,870
+high bcalcemiaالـ Hypoparathyroidism يعني انخفاض
+
+283
+00:24:26,870 --> 00:24:32,370
+مستوى هرمون البارا ثيرويد هرمون لما بتجل البارا
+
+284
+00:24:32,370 --> 00:24:36,470
+ثيرويد هرمون اتفجنا انسان صار عنده انخفاض في ال
+
+285
+00:24:36,470 --> 00:24:41,080
+ionized calciumلو هو طبيعي، الـ Parathyroid هرمون
+
+286
+00:24:41,080 --> 00:24:45,000
+إيش وظيفتها؟ تروح للكلة، تحكي لها اعمل إعادة
+
+287
+00:24:45,000 --> 00:24:49,200
+انتصاف، اتروح للـ bone، اطلع الكالسيوم من الـ bone
+
+288
+00:24:49,200 --> 00:24:53,620
+للدم، لكن لو أنت أصلا عندك Hypoparathyroidism،
+
+289
+00:24:53,620 --> 00:24:57,240
+يعني عندك انخفاض أصلا في الهرمون، معناه ال action
+
+290
+00:24:57,240 --> 00:25:01,860
+تبع هذا الهرمون مش هيصير، معناه هيضل الجسم يعاني
+
+291
+00:25:01,860 --> 00:25:07,960
+من الـ Hypocalcemiaحالات الـ Alkalosis أو الكيميا
+
+292
+00:25:07,960 --> 00:25:11,580
+الـ Alkalemia
+
+293
+00:25:11,580 --> 00:25:17,040
+أو الـ Alkalosis اللي هو ارتفاع الـ pH تبع الدم
+
+294
+00:25:17,040 --> 00:25:22,520
+الأشخاص اللي عندهم الـ pH عالي مش neutral هدول
+
+295
+00:25:22,520 --> 00:25:26,540
+الأشخاص بيكون عندهم نقص في الـ Ionized Calcium زي
+
+296
+00:25:26,540 --> 00:25:30,380
+ما حكيناها بالـ slide اللي جابل تمام أما الـ
+
+297
+00:25:30,380 --> 00:25:34,160
+Hypercalcemiaالرتفاع مستوى الـ Ionized Calcium في
+
+298
+00:25:34,160 --> 00:25:39,000
+الدم عدة أسباب Hyperparathyroidism يعني الـ
+
+299
+00:25:39,000 --> 00:25:43,220
+Parathyroid هرمون الـ action يعني الهرمون موجود
+
+300
+00:25:43,220 --> 00:25:48,300
+بكميات كتير كبيرة أكتر من الطبيعي Hyper وبالتالي
+
+301
+00:25:48,300 --> 00:25:51,860
+هيشتغل على ال kilo و هيشتغل على ال bone بشكل أكبر
+
+302
+00:25:51,860 --> 00:25:56,980
+هيطلع ال calcium من ال bone للدمهيروح للكلة يعطيها
+
+303
+00:25:56,980 --> 00:26:01,200
+أوامر إعادة امتصاص للكالسيوم دايما وبالتالي إيش
+
+304
+00:26:01,200 --> 00:26:05,220
+المحصلة هيزيد مستوى ال ionized calcium Malignancy
+
+305
+00:26:05,220 --> 00:26:10,200
+of bone سرطانات في ال bone هيؤدي ذلك إلى تسرب
+
+306
+00:26:10,200 --> 00:26:13,960
+الكالسيوم من ال bone إلى ال blood هيطلع الكالسيوم
+
+307
+00:26:13,960 --> 00:26:19,680
+من العضم إلى الدم في حالة ال malignancyالـ
+
+308
+00:26:19,680 --> 00:26:23,540
+Thyrotoxicosis Thyrotoxicosis وجود .. هتاخدوا هذه
+
+309
+00:26:23,540 --> 00:26:28,180
+المصطلحات في كورس الهرمونات وجود مشكلة في الـ
+
+310
+00:26:28,180 --> 00:26:32,480
+Thyroid hormone Thyroid hormone ترتفع أكتر من
+
+311
+00:26:32,480 --> 00:26:37,260
+الطبيعي إذا سمعتوا عنهم الـ T3 و T4 تمام؟ طب إيش
+
+312
+00:26:37,260 --> 00:26:43,210
+دخلهم؟بحُكم أنه الغُدّة الدرقية جنب الغُدّة
+
+313
+00:26:43,210 --> 00:26:47,430
+الجاردرقية هما جنب بعيد موجودين فلما بيصير عندي
+
+314
+00:26:47,430 --> 00:26:50,690
+مشكلة بالغُدّة الدرقية already هتأثر على الغُدّة
+
+315
+00:26:50,690 --> 00:26:55,430
+التانية الجاردرقية هذه جثة الـthyrotoxicosis برضه
+
+316
+00:26:55,430 --> 00:26:58,670
+في الـthyrotoxicosis مش هرمونات الغُدّة الدرقية بس
+
+317
+00:26:58,670 --> 00:27:02,670
+بترتفع لهم T3 وT4 برضه الـparathyroid hormone
+
+318
+00:27:02,670 --> 00:27:07,430
+هيرتفع يعني هيصير عندي sorry هيصير عنديالـ
+
+319
+00:27:07,430 --> 00:27:12,020
+HyperparathyroidismVitamin D Intoxication إيش
+
+320
+00:27:12,020 --> 00:27:16,400
+يعني؟ يعني Vitamin D موجود بتركيز عالي جدا جدا
+
+321
+00:27:16,400 --> 00:27:19,840
+أعلى من الطبيعي وهذا التركيز بيكون toxic يعني ممكن
+
+322
+00:27:19,840 --> 00:27:25,220
+يموت الإنسان أو يدمر عنده أنسجة معينة فلما بيزيد
+
+323
+00:27:25,220 --> 00:27:29,820
+برضه Vitamin D التفاجنة هيحفظ الأمعاق بشكل مضاعف
+
+324
+00:27:29,820 --> 00:27:34,040
+تعمل إعادة إمتصاص لكالسيوم ممكن يكون حالات اديوبثك
+
+325
+00:27:34,040 --> 00:27:38,540
+مجهولة بتأدي لزيادة مستوى ال ionized calcium في
+
+326
+00:27:38,540 --> 00:27:41,710
+الدمالسلام عليكم و رحمه اللهنجي للفحص التاني
+
+327
+00:27:41,710 --> 00:27:46,210
+الفوسفوريس فوسفوريس is an essential mineral for
+
+328
+00:27:46,210 --> 00:27:50,010
+tissue bone formation and is required by every
+
+329
+00:27:50,010 --> 00:27:53,730
+cell in the body for normal function فوسفوريس من
+
+330
+00:27:53,730 --> 00:27:58,030
+العناصر المعدنية المهمة اللي بتحتاجها جميع الخلايا
+
+331
+00:27:58,030 --> 00:28:04,410
+من أجل أداء وظيفها أيضا عشان ال bone formation لما
+
+332
+00:28:04,410 --> 00:28:09,990
+بيصير إنه تكوين عظام أيضا الفوسفوريس بتحتاج العظام
+
+333
+00:28:10,110 --> 00:28:17,430
+من أجل تكوينها، تمام؟approximately حوالي 85% من ال
+
+334
+00:28:17,430 --> 00:28:21,550
+body phosphorus is found in bone and in teeth خمسة
+
+335
+00:28:21,550 --> 00:28:26,410
+و تمانين في المية من ال phosphorus مخزن جواة العظم
+
+336
+00:28:26,410 --> 00:28:30,990
+مع ال calcium هو ال calcium مشيين مع بعض مخزن داخل
+
+337
+00:28:30,990 --> 00:28:35,030
+ال bone و في ال teeth أيضا و في الأسنان ال low
+
+338
+00:28:35,030 --> 00:28:39,290
+levels of phosphorus يعني انخفاض مستوى ال
+
+339
+00:28:39,290 --> 00:28:45,370
+phosphorus في الدمCan be caused by مين بيسببه الـ
+
+340
+00:28:45,370 --> 00:28:50,150
+Hypervitaminosis Primary Hyperparathyroidism Renal
+
+341
+00:28:50,150 --> 00:28:54,310
+Tupular Disorder الـ Antacid أو الـ Malabsorption
+
+342
+00:28:54,310 --> 00:28:57,890
+بتكون تركزوا معي شغلتين شوية بعاد عن الكلام هذا
+
+343
+00:28:59,050 --> 00:29:05,130
+بتكونوا تعرفوا إن Vitamin Dال إتفجنا إنه بيحفظ
+
+344
+00:29:05,130 --> 00:29:10,470
+إعادة إمتصاص الكالسيوم، صح ولا لأ؟ أيضًا شغله مع
+
+345
+00:29:10,470 --> 00:29:15,170
+الفوسفورس نفس الكلام Vitamin Dال بيشتغل على
+
+346
+00:29:15,170 --> 00:29:22,530
+الأنعاقوبيحفظ الأمعاء أيضًا تعمل إعادة امتصاص لـ
+
+347
+00:29:22,530 --> 00:29:26,750
+Phosphorus على الدم وممنوع يطلع برا الستول يعني
+
+348
+00:29:26,750 --> 00:29:31,910
+ممنوع يطلع مع الستول، تمام؟ إذا شغل Vitamin D لـ
+
+349
+00:29:31,910 --> 00:29:36,370
+Phosphorus وكالسيوم زي بعض إنه بيصير لهم إعادة
+
+350
+00:29:36,370 --> 00:29:41,430
+امتصاص، تمام؟ أما الـ Parathyroid hormone هذه
+
+351
+00:29:41,430 --> 00:29:41,950
+الغدة
+
+352
+00:29:45,230 --> 00:29:49,250
+البراتيرويد هرمون هذا الهرمون اتفجنا انه بيشتغل
+
+353
+00:29:49,250 --> 00:29:53,990
+على البون وبيشتغل على الكلة شغله على الكلة انه
+
+354
+00:29:53,990 --> 00:30:00,010
+يعمل إعادة امتصاص للكالسيوم صح ولا لا؟لكن شغله مع
+
+355
+00:30:00,010 --> 00:30:04,870
+الفوسفور مختلف شغله مع الفوسفور إنه بيحفظ الـ
+
+356
+00:30:04,870 --> 00:30:09,450
+Parathyroid hormone بيحفظ الكيلة تعمل Execration
+
+357
+00:30:09,450 --> 00:30:15,070
+للفوسفور تمام؟ برا تترضه مع الـ urine إذا شغل
+
+358
+00:30:15,070 --> 00:30:20,090
+vitamin D للكالسيوم والفوسفور واحد وشغل ال
+
+359
+00:30:20,090 --> 00:30:27,000
+Parathyroid hormoneوشغل الـ Parathyroid هرمون
+
+360
+00:30:27,000 --> 00:30:32,280
+للفوسفورث والكالسيوم عكس بعد بتطلع الكالسيوم برا
+
+361
+00:30:32,280 --> 00:30:39,160
+الجسم مع اليورين وبتحفظ الكلا شغل ال Parathyroid
+
+362
+00:30:39,160 --> 00:30:43,720
+هرمون على الكلا انه بتحكي للكلا اعملي اعادة امتصاص
+
+363
+00:30:43,720 --> 00:30:49,400
+للكالسيوم واعملي execution للفوسفورث مع اليورين
+
+364
+00:30:49,400 --> 00:30:56,550
+تمام؟إذن بينخفض مستوى الفوسفور في الدم لو صار عندي
+
+365
+00:30:56,550 --> 00:31:02,670
+Hypervitaminosis طب كيف؟ هتحكولي إن Vitamin D
+
+366
+00:31:02,670 --> 00:31:08,770
+بالعكس بعمل إعادة انتصاف للفوسفور و بيرجعه على
+
+367
+00:31:08,770 --> 00:31:14,860
+الدم صحيح هذا الوضع الطبيعي لكن لو ذات Vitamin Dعن
+
+368
+00:31:14,860 --> 00:31:21,440
+حده يعني صار intoxication يعني وصل لـ dose لجرعة
+
+369
+00:31:21,440 --> 00:31:26,080
+السمية في الجسم hypervitaminosis يعني عالي كتير
+
+370
+00:31:26,080 --> 00:31:30,540
+كتير هيحفظ الأمعاق تعمل execution للـ phosphorus
+
+371
+00:31:30,540 --> 00:31:35,080
+مع الستول، تمام؟ لكن هو الطبيعي بيعمله إعادة
+
+372
+00:31:35,080 --> 00:31:39,380
+امتصاص، لكن لو زاد مستوى للـ vitamin دال، هيعمل
+
+373
+00:31:39,380 --> 00:31:44,270
+شغل عكس شغله الطبيعيPrimary Hyperparathyroidism
+
+374
+00:31:44,270 --> 00:31:49,430
+يعني حدوث ارتفاع في الـ Parathyroid هرمون بشكل
+
+375
+00:31:49,430 --> 00:31:53,290
+هائل، Hyper هذه الحالة اتفجنا، ما ال Parathyroid
+
+376
+00:31:53,290 --> 00:31:57,750
+هرمون إيش بتعمل؟ بتعمل Execration للفسفور مع
+
+377
+00:31:57,750 --> 00:32:01,270
+اليورين وبالتالي لو زاد هذا الهرمون، معناه ال
+
+378
+00:32:01,270 --> 00:32:06,010
+Execration هيزيد وبالتالي هيقل مستوى الفسفور في
+
+379
+00:32:06,010 --> 00:32:11,780
+الدم لأنه في هرمون بحفظ خروجه برا الجسمRenal
+
+380
+00:32:11,780 --> 00:32:16,560
+Tupular Disorder مشاكل في لتيوبيول تبعت الكلة مش
+
+381
+00:32:16,560 --> 00:32:21,040
+جادرة لتيوبيول تعمل إعادة انتصاص وبالتالي بتطلع
+
+382
+00:32:21,040 --> 00:32:24,640
+الفوسفور لبرا مع ال urine الناس اللي بتاخد Anti
+
+383
+00:32:24,640 --> 00:32:29,940
+Acid تاخد الأدوية ضد الحموضةبرضه هذه بتخفض مستوى
+
+384
+00:32:29,940 --> 00:32:33,280
+الفسفور في الدم أو الـmal absorption أكيد شخص عنده
+
+385
+00:32:33,280 --> 00:32:38,740
+سوء امتصاص فعالفاضي إيش ما ياكل وإيش ما يشرب مش
+
+386
+00:32:38,740 --> 00:32:45,000
+هيصير عنده امتصاص للشغلة وإعادة إرجاع تمام؟high
+
+387
+00:32:45,000 --> 00:32:49,180
+levels of phosphorus أما ارتفاع مستوى الفوسفور في
+
+388
+00:32:49,180 --> 00:32:53,960
+الدم can be caused by إذا أنت أكلت أكلات مليانة
+
+389
+00:32:53,960 --> 00:32:58,840
+فوسفور أكيد هيرتفع المستوى البون ميتاستاسز حدوث
+
+390
+00:32:58,840 --> 00:33:04,790
+كانسر في البونحكيتلكم هيتسرب .. هتتسرب المعادن
+
+391
+00:33:04,790 --> 00:33:07,350
+الموجود في ال .. موجودة في الـ bone الكالسيوم و
+
+392
+00:33:07,350 --> 00:33:10,750
+الفوسفور الاتنين هيطلعوا لبرا، هيطلعوا للدم
+
+393
+00:33:10,750 --> 00:33:14,250
+وبالتالي هيزيد تركيزهم في الدم حالات الـ liver
+
+394
+00:33:14,250 --> 00:33:17,770
+disease، حالات الـ alcohol ingestion، حالات
+
+395
+00:33:17,770 --> 00:33:21,670
+الدياريا، ال vomiting، دي كلها dehydration، جفاف،
+
+396
+00:33:21,670 --> 00:33:26,130
+معناه هيتركز المعادن في بلازم الدمClinical
+
+397
+00:33:26,130 --> 00:33:29,150
+diagnosis shouldn't be made on a single test
+
+398
+00:33:29,150 --> 00:33:33,830
+result عشان أنا أشخص ممنوع نتيجة فحص واحد it
+
+399
+00:33:33,830 --> 00:33:36,470
+should integrate clinical and other laboratory
+
+400
+00:33:36,470 --> 00:33:41,410
+data بدنا أكتر من فحص نعمله مع بعض عشان نشيك على
+
+401
+00:33:41,410 --> 00:33:47,570
+وضع أي عضو في الجسمالـ Regulation تنظيم الفوسفورس
+
+402
+00:33:47,570 --> 00:33:51,770
+الـ phosphate in blood maybe هلجت الفوسفور اتفجنا
+
+403
+00:33:51,770 --> 00:33:57,110
+انه 85% منه موجودة في البون والجزء المتبقي موجود
+
+404
+00:33:57,110 --> 00:34:03,030
+في بلاذم الدم تمام؟هل جيت الفوسفيت اللي موجود سواء
+
+405
+00:34:03,030 --> 00:34:06,410
+فوسفيت أو فوسفورس نفس المصطلح الفوسفيت اللي موجود
+
+406
+00:34:06,410 --> 00:34:10,530
+في الدم من وين مصدره absorbed in the intestine
+
+407
+00:34:10,530 --> 00:34:15,150
+from dietary sources أول مصدر الأكل إنسان بياكل
+
+408
+00:34:15,150 --> 00:34:20,150
+أكلات مليانة فوسفور الأنعاق بيصير في انتصاص لهذا
+
+409
+00:34:20,150 --> 00:34:25,890
+الأكل الأنعاق هتعمل إعادة انتصاصللفسفور هذا اللي
+
+410
+00:34:25,890 --> 00:34:30,050
+موجود في الأكل و ترجعه للدم تمام؟ إذا عرفنا
+
+411
+00:34:30,050 --> 00:34:34,190
+الفسفور اللي موجود في الدم مصدره من الـ diet من
+
+412
+00:34:34,190 --> 00:34:39,590
+الأكلممكن الفسفور released from cells into blood
+
+413
+00:34:39,590 --> 00:34:44,830
+في خلايا معينة ممكن يكون جواها موجود الفسفور فممكن
+
+414
+00:34:44,830 --> 00:34:48,670
+يطلع من هذه الخلايا إلى الدم and lost from bone
+
+415
+00:34:48,670 --> 00:34:53,010
+برضه الفسفور اللي موجود في الدم ممكن يكون مصدره من
+
+416
+00:34:53,010 --> 00:34:58,730
+البون إن البون بدأت تسرب فسفور و تطلع للدم تمام؟
+
+417
+00:34:59,450 --> 00:35:05,230
+إذا مصادره من الأكل والأمعاء ودته للدم من خلايا
+
+418
+00:35:05,230 --> 00:35:09,270
+أخرى غير خلايا الأمعاء ومن الـ bone هذا مصادر
+
+419
+00:35:09,270 --> 00:35:12,550
+الفوسفور الموجود في الدم in healthy individuals
+
+420
+00:35:12,550 --> 00:35:16,290
+عند الناس الطبيعيين all these processes are
+
+421
+00:35:16,290 --> 00:35:19,870
+relatively constant and easily regulated by هذه
+
+422
+00:35:19,870 --> 00:35:23,890
+التلت عمليات اللي أنا حكيتها إنه بناكله والأمعاء
+
+423
+00:35:23,890 --> 00:35:28,490
+بتعملوا إعادة امتصاصخروج الفسفور من وإلى الخلايا
+
+424
+00:35:28,490 --> 00:35:33,210
+فقده من الـ bone هذه عمليات طبيعية بتسير في الجسم
+
+425
+00:35:33,210 --> 00:35:39,390
+وعمليات منظمة بصيرلها regulation تمام؟ومين بيعملها
+
+426
+00:35:39,390 --> 00:35:42,750
+ال regulation أول إيش الكلا؟ يعني الرينا ال
+
+427
+00:35:42,750 --> 00:35:46,850
+execution في حال أنا بديش فسفور زيادة في الدم إيش
+
+428
+00:35:46,850 --> 00:35:51,450
+بتعمل الكلا؟ بتعمل execution لهذا الفسفور عن طريق
+
+429
+00:35:51,450 --> 00:35:54,410
+ال urine بتطلعه مع ال urine يعني لازم يصير فيه
+
+430
+00:35:54,410 --> 00:36:00,300
+تنظيم أو reabsorption أو ممكن لو أنا بديالفوسفور
+
+431
+00:36:00,300 --> 00:36:04,480
+محتاجة فوسفور ممكن الأمعاء تعمل إعادة انتصاص ممكن
+
+432
+00:36:04,480 --> 00:36:08,940
+الكلا تعمل إعادة انتصاص إذا حسب حازة الجسم الكلا
+
+433
+00:36:08,940 --> 00:36:15,040
+بتشتغل تمام؟الـ Regulation، تنظيم مستوى الفوسفور
+
+434
+00:36:15,040 --> 00:36:20,720
+في الدم حكيناها، لخصهم عجباً Vitamin DL بيعمل
+
+435
+00:36:20,720 --> 00:36:26,220
+إعادة انتصاص للفوسفور، تمام؟ أول إشي Vitamin DL
+
+436
+00:36:26,220 --> 00:36:29,700
+اللي أصله بيتصنع هو في الكلا، تمام؟ في الـ kidney
+
+437
+00:36:29,700 --> 00:36:33,860
+Vitamin DL بشتغل على الأمعاء و بيخلل الأمعاء تعمل
+
+438
+00:36:33,860 --> 00:36:39,310
+إعادة انتصاص للفوسفور وترجعه للدم، تمام؟أما الـ
+
+439
+00:36:39,310 --> 00:36:44,990
+Parathyroid hormone بيشتغل على الكلة وبيحكي للكلة
+
+440
+00:36:44,990 --> 00:36:50,750
+اعمل execution للفسفور إذا نقرأ رينال ريجوليشن is
+
+441
+00:36:50,750 --> 00:36:55,030
+affected by factors such as يعني الكلة و تنظيمات
+
+442
+00:36:55,030 --> 00:36:59,050
+الكلة بتتأثر بشغلتين بالفيتاميندال و بال
+
+443
+00:36:59,050 --> 00:37:03,370
+Parathyroid hormoneIncreases both phosphate
+
+444
+00:37:03,370 --> 00:37:06,770
+absorption in the intestine and phosphate
+
+445
+00:37:06,770 --> 00:37:09,090
+reabsorption in the kidney
+
+446
+00:37:13,510 --> 00:37:19,490
+بشتغل على الأمعاء وعلى الانتستان وبعمل إعادة
+
+447
+00:37:19,490 --> 00:37:23,470
+انتصاص للفوسفات وبالتالي تركيز الفوسفات هيزيد في
+
+448
+00:37:23,470 --> 00:37:28,490
+الدم وأيضا Vitamin Dال بشتغل على الكيلة وبحفظ
+
+449
+00:37:28,490 --> 00:37:32,630
+الكيلة تعمل إعادة انتصاص للفوسفار تعمل
+
+450
+00:37:32,630 --> 00:37:38,360
+Reabsorption للفوسفارأما الـ Parathyroid hormone
+
+451
+00:37:38,360 --> 00:37:42,560
+بشتغل مش على الأمعاء لكن بشتغل على ال kidney،
+
+452
+00:37:42,560 --> 00:37:46,840
+الكله نفسها lowers blood concentrations by
+
+453
+00:37:46,840 --> 00:37:51,120
+increasing renal excretion يخف ال Parathyroid
+
+454
+00:37:51,120 --> 00:37:56,100
+hormone يخفض مستوى الفوسفور من خلال أنه بيحفظ
+
+455
+00:37:56,100 --> 00:38:01,440
+الكله تعمل إخراج للفوسفور خارج الجسم وبالتالي هيقل
+
+456
+00:38:01,440 --> 00:38:06,720
+مستوى الفوسفور في الدمprinciple of the method زي
+
+457
+00:38:06,720 --> 00:38:11,460
+طريقة الكالسيوم انه طريقة colorimetric ان الفوسفار
+
+458
+00:38:11,460 --> 00:38:15,440
+اللي فيه بلازمة الدم برتبط مع مادة موجودة في ال
+
+459
+00:38:15,440 --> 00:38:19,760
+reagent وحصلت التفاعل اعطاء complex ملون ال
+
+460
+00:38:19,760 --> 00:38:23,040
+complex هنا بيكون لونه أزرق اللون اللي بنتج عن
+
+461
+00:38:23,040 --> 00:38:28,160
+التفاعل أزرق تمام؟الـ Organic Phosphorus، الفسفور
+
+462
+00:38:28,160 --> 00:38:34,620
+الموجود في الدم Reacts with molybdic acid forming
+
+463
+00:38:34,620 --> 00:38:40,180
+a phosphomolybdic complex الموليبدك أسد هذا حمض
+
+464
+00:38:40,180 --> 00:38:43,530
+موجود في الـ Reagentبتفاعل مع الـ Inorganic
+
+465
+00:38:43,530 --> 00:38:47,270
+Phosphorus اللي موجود في عينة المريض تعطيني
+
+466
+00:38:47,270 --> 00:38:51,830
+Complex M1 it is subsequent reduction in alkaline
+
+467
+00:38:51,830 --> 00:38:56,870
+medium originate a blue color فحصلت التفاعل اللون
+
+468
+00:38:56,870 --> 00:39:01,890
+الأزرقوالـ pH بتكون alkaline تبع الـ reagent الـ
+
+469
+00:39:01,890 --> 00:39:05,130
+intensity of the color formed is proportional to
+
+470
+00:39:05,130 --> 00:39:07,730
+the inorganic phosphorus concentration in the
+
+471
+00:39:07,730 --> 00:39:11,070
+sample شدت اللوم تتناسب تناسب ترضي مع تركيز
+
+472
+00:39:11,070 --> 00:39:16,260
+الفسوفوري الموجود في البلازمة تبع الدمالـ
+
+473
+00:39:16,260 --> 00:39:22,000
+Reference Range للفوسفورس عند الـ Adult من 2.5 ل 5
+
+474
+00:39:22,000 --> 00:39:26,680
+milligram per deciliter برضه صحوا الوحدة مش بالـ
+
+475
+00:39:26,680 --> 00:39:31,560
+micro لـ Children من 4 إلى 7 برضه بتلاحظوا الـ
+
+476
+00:39:31,560 --> 00:39:34,580
+Total Calcium و الفوسفورس أعلى عند الـ Children
+
+477
+00:39:34,580 --> 00:39:38,900
+لأن عضمهم لسه في مرحلة بناء وبالتالي الـ Bone
+
+478
+00:39:38,900 --> 00:39:43,320
+Formation تكوين العظام بتطلب وجود كالسيوم و
+
+479
+00:39:43,320 --> 00:39:48,720
+فوسفورس تمام؟هي لو بدنا التركيز بالـ Micromoleper
+
+480
+00:39:48,720 --> 00:39:54,680
+liter فالوحدة بالmilligram per deciliter سريع
+
+481
+00:39:54,680 --> 00:39:58,880
+الوحدة الأخرى millimol per liter بدنا نحول من
+
+482
+00:39:58,880 --> 00:40:02,760
+milligram per deciliter لmillimol per liter فغيروا
+
+483
+00:40:02,760 --> 00:40:07,720
+عندكم مش micromol per liter millimol وmilligram
+
+484
+00:40:07,720 --> 00:40:11,040
+تمام؟ وفي ال total calcium نفس الوحدات milligram
+
+485
+00:40:11,040 --> 00:40:18,280
+per deciliter وmillimol per literALB الـ Alkaline
+
+486
+00:40:18,280 --> 00:40:22,340
+Phosphatase يمكن حكينا عنه كثير كثير في حالات
+
+487
+00:40:22,340 --> 00:40:27,840
+تشييك على وضع الكبد على ال liver صح ولا لا؟
+
+488
+00:40:27,840 --> 00:40:31,020
+Alkaline Phosphatase is an enzyme present in
+
+489
+00:40:31,020 --> 00:40:34,720
+almost all parts of the organism being
+
+490
+00:40:34,720 --> 00:40:38,310
+particularly high in pointLiver, Placenta,
+
+491
+00:40:38,670 --> 00:40:42,810
+Intestine, Kidney تفاجنا إن الـ ALB عبارة عن
+
+492
+00:40:42,810 --> 00:40:48,210
+إنزاين تقريبا موجود في كل التشوة تبع الجسم يعني كل
+
+493
+00:40:48,210 --> 00:40:52,630
+الأعضاء اللي في الجسم فيها ALB فيها الـ Alkaline
+
+494
+00:40:52,630 --> 00:40:58,490
+Phosphatase ولكن موجود بتركيز أعلى في خمس مناطق
+
+495
+00:40:58,490 --> 00:41:02,790
+بتركز في الـ Bone وفي الـ Liver وفي الـ Placenta و
+
+496
+00:41:02,790 --> 00:41:08,070
+الـ Intestine و الـ Kidney تمام؟Poth increases and
+
+497
+00:41:08,070 --> 00:41:11,430
+decreases of plasma ALP are of importance
+
+498
+00:41:11,430 --> 00:41:16,170
+clinically بيحكيلي انخفاض أو ارتفاع مستوى ال ALP
+
+499
+00:41:16,170 --> 00:41:22,650
+مهم جدا في التشخيص Causes of increased plasma ALP
+
+500
+00:41:22,650 --> 00:41:27,050
+إيش الشغلات اللي بترفع من مستوى ال ALP في الدم
+
+501
+00:41:27,050 --> 00:41:31,170
+يعني بتزود تركيز هذا ال enzyme في الدمالـ Budget
+
+502
+00:41:31,170 --> 00:41:34,630
+Disease of Bone هتاخدوه مع الدكتور مازن Budget
+
+503
+00:41:34,630 --> 00:41:40,750
+Disease مرض وراسي بيصيب البون بتبدأ يعني في هذا
+
+504
+00:41:40,750 --> 00:41:45,310
+المرض بيصير الـ ALB يطلع من البون إلى الدم
+
+505
+00:41:45,310 --> 00:41:48,890
+وبالتالي بيزيد تركيزه في الدم حالات الـ
+
+506
+00:41:48,890 --> 00:41:54,690
+Obstructive Liver Disease تكون يعني حصاوي في الـ
+
+507
+00:41:54,690 --> 00:42:00,160
+Biliary Duct في القناع السفراويةوبالتالي الخلايا
+
+508
+00:42:00,160 --> 00:42:04,540
+المكوّنة للقضايا الصفروية بتبدأ تفرز الـ ALB تفجنا
+
+509
+00:42:04,540 --> 00:42:10,240
+أخدنا هذا الكلام حالات الـ Hepatitis التهاب خلايا
+
+510
+00:42:10,240 --> 00:42:16,800
+الكبد حالات الـ Hepatotoxicity caused by drug يعني
+
+511
+00:42:16,800 --> 00:42:23,540
+حدوث مشكلة في خلايا الكبد بسبب تناول الـ Drug معين
+
+512
+00:42:23,540 --> 00:42:29,330
+أدى إلى الـ toxicity لهذه الخلايابرضه هيرفع من
+
+513
+00:42:29,330 --> 00:42:33,110
+مستوى ال ALP حالات الـ Osteomalacia تشبه الـ
+
+514
+00:42:33,110 --> 00:42:36,970
+Osteoporesis في الفرق بينهم بس تجاوزا بنحكي نفس
+
+515
+00:42:36,970 --> 00:42:41,170
+الأشياء أن فيها شاشة في العظم وبالتالي ال ALP مركز
+
+516
+00:42:41,170 --> 00:42:46,910
+الحضن العظم فهيصير يطلع من العظم إلى الدمCauses of
+
+517
+00:42:46,910 --> 00:42:50,990
+decreased plasma ALP مستوى الـ ALP بنخفض في الدم
+
+518
+00:42:50,990 --> 00:42:55,770
+في حالات الـ Creatinism التقزم أو القزمة بيحكوا
+
+519
+00:42:55,770 --> 00:43:00,230
+عنها و Vitamin C deficiency انخفاض في Vitamin C
+
+520
+00:43:00,230 --> 00:43:05,640
+بيؤدي إلى انخفاض في مستوى الانزايم الـ ALPالـ
+
+521
+00:43:05,640 --> 00:43:10,220
+Principle of the Method ALB Enzyme بسرعة بنروح
+
+522
+00:43:10,220 --> 00:43:14,820
+تفكيرنا إلى إن الشغل هيكون Kinetic ناخد أكتر من
+
+523
+00:43:14,820 --> 00:43:20,520
+Absorbance هتتكون عندي مُركّب إحنا بدنا نقيث معدل
+
+524
+00:43:20,520 --> 00:43:25,320
+تكوين هذا المُركّب مثلا عند one minute عند two
+
+525
+00:43:25,320 --> 00:43:29,080
+minute عند three minute وهذا كله هيعبّر عن ال
+
+526
+00:43:29,080 --> 00:43:34,180
+activity تبع ال enzymeنقرأ الـ «الكالاين
+
+527
+00:43:34,180 --> 00:43:37,600
+فوسفاتيزل» الـ ALB «الكالاين فوسفاتيزل» الـ ALB
+
+528
+00:43:37,600 --> 00:43:37,960
+«الكالاين فوسفاتيزل» الـ ALB «الكالاين فوسفاتيزل»
+
+529
+00:43:37,960 --> 00:43:39,800
+الـ ALB «الكالاين فوسفاتيزل» الـ ALB «الكالاين
+
+530
+00:43:39,800 --> 00:43:42,060
+فوسفاتيزل» الـ ALB «الكالاين فوسفاتيزل» الـ ALB
+
+531
+00:43:42,060 --> 00:43:46,520
+«الكالاين فوسفاتيزل» الـ ALB «الكالاين فوسفاتيزل»
+
+532
+00:43:46,520 --> 00:43:48,620
+الـ ALB «الكالاين فوسفاتيزل» الـ ALB «الكالاين
+
+533
+00:43:48,620 --> 00:43:58,020
+فوسفاتيزل» الـ ALB «الكالاين فوسفاتيزل»
+
+534
+00:43:58,020 --> 00:44:01,400
+الـ ALB «الالـ Reagent اللي جاي من الشركة بيكون
+
+535
+00:44:01,400 --> 00:44:06,240
+فيه substrate اسمها بارا نيترو فينول فوسفات وبيكون
+
+536
+00:44:06,240 --> 00:44:10,960
+أيضا فيه مغنيسيوم كـ Co-factor بيساعد على شغل
+
+537
+00:44:10,960 --> 00:44:15,420
+إنزايم الـ ALB تمام؟ وميّه هذه مكونات الـ Reagent
+
+538
+00:44:15,420 --> 00:44:19,120
+هلجيت لما بنخلط الـ Reagent على العينة الإنزايم
+
+539
+00:44:19,120 --> 00:44:23,320
+هيكسر ال substrate ويعطيني البارا نيترو فينول و
+
+540
+00:44:23,320 --> 00:44:28,190
+فوسفات؟هل جيت انا تفاجنا انه قاينتك يعني انا مابدي
+
+541
+00:44:28,190 --> 00:44:32,110
+اقيس شدة اللون انا بعرف البارا نيتروفينول هذه مادة
+
+542
+00:44:32,110 --> 00:44:37,730
+ملونة انا مابدي اجيث لونها عند point معينة عند
+
+543
+00:44:37,730 --> 00:44:43,910
+نقطة معينة لأ انا بدي اقيس معدل تكوين البارا
+
+544
+00:44:43,910 --> 00:44:49,390
+نيتروفينول عند 1 minute و 2 minute و 3 minute و 4
+
+545
+00:44:49,390 --> 00:44:55,000
+minute وهذا التغير في معدل التكوينهو اللي هيعبّر
+
+546
+00:44:55,000 --> 00:45:00,340
+عن الـ activity تبعت الإنزين نفس شغل الإنزيمات بس
+
+547
+00:45:00,340 --> 00:45:03,640
+الفرق إنه في الإنزيمات السابقة مين اللي كان يتكون
+
+548
+00:45:03,640 --> 00:45:07,240
+الند، الند أتش هذا المُركّب بس اليوم عندي الـ
+
+549
+00:45:07,240 --> 00:45:11,320
+Paranitrophenol يعني هنا مش هيكون القراعة 340
+
+550
+00:45:11,320 --> 00:45:16,230
+انتبهوا لأن ما اتكون الند أتش اتكون مادة أخرىThe
+
+551
+00:45:16,230 --> 00:45:21,070
+Rate of Paranitrophenol Formation معدل تكوين الـ
+
+552
+00:45:21,070 --> 00:45:27,130
+Paranitrophenol بدنا نقيصه على الـ Spectrum وهو
+
+553
+00:45:27,130 --> 00:45:32,430
+بتناسب تناسب ترضي مع تركيز الـ ALB اللي موجود في
+
+554
+00:45:32,430 --> 00:45:37,310
+الـ Sampleالـ procedure يا جماعة نفس الـ procedure
+
+555
+00:45:37,310 --> 00:45:42,190
+بالظبط تبعت من؟ تبعت الـ AST والـ ALT انشرحت في
+
+556
+00:45:42,190 --> 00:45:48,010
+المعمل أول إشي إيش بنروح بنجيب؟ بنروح نجيب بلاستيك
+
+557
+00:45:48,010 --> 00:45:53,710
+تيوب و بنحطها في الـ water bath تمام؟ باخد الـ kit
+
+558
+00:45:53,710 --> 00:45:57,750
+تبع شغل ال ALP في two reagents reagent A و reagent
+
+559
+00:45:57,750 --> 00:46:01,850
+B تاخدي 800 ميكرو ليتر من ال reagent A و بتحطيها
+
+560
+00:46:01,850 --> 00:46:06,490
+في ال tubeبعدين بتجيبى 20 مايكرون من السيرام و
+
+561
+00:46:06,490 --> 00:46:11,770
+بتحطيها فوق ال 800 و بتعملي mix منيح طبعا شغلي ع
+
+562
+00:46:11,770 --> 00:46:16,830
+37 يعني أنا ده كله عملته في ال water bath و بقى
+
+563
+00:46:16,830 --> 00:46:22,910
+خليهم مدة 5 minuteبعد خمسة minute بروح أجيب
+
+564
+00:46:22,910 --> 00:46:28,210
+reagent P باخد منه 200 مايكرون و بحطهم فوق ال mix
+
+565
+00:46:28,210 --> 00:46:33,790
+اللي أنا أصلا حدرته أول ما حطت ال 200 مايكرون من
+
+566
+00:46:33,790 --> 00:46:39,810
+reagent P start stopwatch بتشغل الساعة بسرعة و
+
+567
+00:46:39,810 --> 00:46:44,650
+بتروحي تاخدي هذا ال mix اللي موجودفي الـ tube و
+
+568
+00:46:44,650 --> 00:46:48,870
+بنديره بالـ cuvette و بناخد الـ cuvette على الجهاز
+
+569
+00:46:48,870 --> 00:46:53,850
+و بنحطها و بنبدأ نحسب ناخد absorbance عند one
+
+570
+00:46:53,850 --> 00:46:57,570
+minute عند two minute عند three minute عند four
+
+571
+00:46:57,570 --> 00:47:02,570
+minute يعني بناخد أربع absorbance الجهاز بدي يكون
+
+572
+00:47:02,570 --> 00:47:08,050
+مضبوط على 405 nanometer بنصفر على distilled water
+
+573
+00:47:08,050 --> 00:47:13,370
+تمام؟جبل ما انا اصلا احط العينة تبعتي جوات الـ
+
+574
+00:47:13,370 --> 00:47:17,590
+Spectrum و بدي اكون مسافرة على ميه و بناخد 4
+
+575
+00:47:17,590 --> 00:47:22,680
+absorbentsوالحص با زي ما انتوا عارفين absorbance
+
+576
+00:47:22,680 --> 00:47:26,420
+الأول من التاني بطرحه والتاني من التالت والتالت من
+
+577
+00:47:26,420 --> 00:47:30,320
+الرابع بطلع عندي تلاتة absorbance باخدلهم ال
+
+578
+00:47:30,320 --> 00:47:34,840
+average بجمعهم و بجسمهم على تلاتة فال absorbance
+
+579
+00:47:34,840 --> 00:47:39,960
+اللي طلع في الآخر بروحه أنا ضرباه ال factor ال
+
+580
+00:47:39,960 --> 00:47:46,550
+factor بيجي مع ال pamphlet الليتبعت الـ kit تمام
+
+581
+00:47:46,550 --> 00:47:55,350
+ال factor تبع ال ALB 2764 نضرب ال average ال
+
+582
+00:47:55,350 --> 00:47:58,670
+absorbance اللي حصلت عليه من ال average بقضربه
+
+583
+00:47:58,670 --> 00:48:02,850
+بهذا ال factor بطلع تركيز ال enzyme بال
+
+584
+00:48:02,850 --> 00:48:06,750
+international unit per liter ال reference range
+
+585
+00:48:06,750 --> 00:48:11,330
+عند ال adultأعلى من 270 international unit per
+
+586
+00:48:11,330 --> 00:48:15,390
+liter عند الـ children أعلى من 800 international
+
+587
+00:48:15,390 --> 00:48:20,970
+unit per liter أيضا ال ALP أعلى من عند ال children
+
+588
+00:48:20,970 --> 00:48:24,450
+أعلى من ال adult لو سألناكم سؤال لأن الأطفال في
+
+589
+00:48:24,450 --> 00:48:30,760
+مرحلة نمو عظامهلجيت العظام تتكون من نوعين من
+
+590
+00:48:30,760 --> 00:48:33,760
+الخلايا مش موجودة عندكم بس اننا نفهمها Osteoplast
+
+591
+00:48:33,760 --> 00:48:37,860
+و Osteoclast Osteoplast تصل هذه الخلايا البناء
+
+592
+00:48:37,860 --> 00:48:42,300
+للعظم و Osteoclast هذه الخلايا الهدامة للعظمهلجيت
+
+593
+00:48:42,300 --> 00:48:46,600
+الـ Osteoplast هاد الخلايا جواتها في الـ ALB
+
+594
+00:48:46,600 --> 00:48:51,340
+جواتها في الـ enzyme فعند الأطفال بيحتاج .. يعني
+
+595
+00:48:51,340 --> 00:48:56,100
+بتكون النشط أكتر الـ Osteoplast النشطة الخلايا
+
+596
+00:48:56,100 --> 00:49:01,360
+البناء للعضم طول ما في بناء للعضم طول ما في ان هذه
+
+597
+00:49:01,360 --> 00:49:04,880
+الخلايا تفرز هذا الـ ALB وبالتالي بيزيد تركيزه
+
+598
+00:49:04,880 --> 00:49:09,380
+بالدم عشان هيك عند الـ Children الـ ALB بيكون أعلى
+
+599
+00:49:09,950 --> 00:49:12,870
+و بهيك خلصنا ال chapter و يعطيكم العافية
+
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/u4q3JwIsRVo_raw.json b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/u4q3JwIsRVo_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..b3690f8a8f8630bdc28ee3288c51cd31c262384a
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/u4q3JwIsRVo_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 1757, "start": 0.0, "end": 17.58, "text": "بدنا نحكي عن ال bone profile test الفحصات اللى بتشيك على وضع العظام أول فحص هو ال calcium calcium is required for cell function overall and for bone metabolism", "tokens": [44510, 8315, 8717, 5016, 4117, 1829, 18871, 2423, 9026, 7964, 1500, 27188, 5016, 9381, 9307, 13672, 7578, 39894, 8592, 1829, 4117, 15844, 4032, 11242, 3615, 18863, 19913, 10943, 5551, 12610, 6156, 5016, 9381, 31439, 2423, 20918, 20918, 307, 4739, 337, 2815, 2445, 4787, 293, 337, 9026, 31190], "avg_logprob": -0.17952473368495703, "compression_ratio": 1.3144654088050314, "no_speech_prob": 1.8477439880371094e-06, "words": [{"start": 0.0, "end": 1.1, "word": "بدنا", "probability": 0.5518798828125}, {"start": 1.1, "end": 1.74, "word": " نحكي", "probability": 0.987060546875}, {"start": 1.74, "end": 2.38, "word": " عن", "probability": 0.9931640625}, {"start": 2.38, "end": 2.68, "word": " ال", "probability": 0.875}, {"start": 2.68, "end": 2.86, "word": " bone", "probability": 0.119384765625}, {"start": 2.86, "end": 3.4, "word": " profile", "probability": 0.8583984375}, {"start": 3.4, "end": 3.88, "word": " test", "probability": 0.921875}, {"start": 3.88, "end": 4.94, "word": " الفحصات", "probability": 0.9129638671875}, {"start": 4.94, "end": 5.18, "word": " اللى", "probability": 0.78515625}, {"start": 5.18, "end": 5.76, "word": " بتشيك", "probability": 0.888427734375}, {"start": 5.76, "end": 6.04, "word": " على", "probability": 0.90185546875}, {"start": 6.04, "end": 6.78, "word": " وضع", "probability": 0.99365234375}, {"start": 6.78, "end": 7.56, "word": " العظام", "probability": 0.9521484375}, {"start": 7.56, "end": 8.16, "word": " أول", "probability": 0.787109375}, {"start": 8.16, "end": 8.62, "word": " فحص", "probability": 0.9881184895833334}, {"start": 8.62, "end": 9.02, "word": " هو", "probability": 0.951171875}, {"start": 9.02, "end": 9.46, "word": " ال", "probability": 0.873046875}, {"start": 9.46, "end": 10.02, "word": " calcium", "probability": 0.857421875}, {"start": 10.02, "end": 11.26, "word": " calcium", "probability": 0.8916015625}, {"start": 11.26, "end": 11.6, "word": " is", "probability": 0.90234375}, {"start": 11.6, "end": 12.16, "word": " required", "probability": 0.86865234375}, {"start": 12.16, "end": 12.9, "word": " for", "probability": 0.97216796875}, {"start": 12.9, "end": 13.54, "word": " cell", "probability": 0.927734375}, {"start": 13.54, "end": 14.4, "word": " function", "probability": 0.95068359375}, {"start": 14.4, "end": 15.22, "word": " overall", "probability": 0.58984375}, {"start": 15.22, "end": 15.96, "word": " and", "probability": 0.9140625}, {"start": 15.96, "end": 16.28, "word": " for", "probability": 0.94189453125}, {"start": 16.28, "end": 16.76, "word": " bone", "probability": 0.90185546875}, {"start": 16.76, "end": 17.58, "word": " metabolism", "probability": 0.9375}], "temperature": 1.0}, {"id": 2, "seek": 4094, "start": 18.1, "end": 40.94, "text": "approximately 99% of body calcium is found in ponds بيحكيلي إنه ال calcium مهم جدا لكل الخلايا عشان تؤدي وظائفها أيضا مهم لبناء العظم أصلا حكينا إن العظم هو المخزن تبع ال calcium", "tokens": [35821, 3081, 1592, 11803, 4, 295, 1772, 20918, 307, 1352, 294, 280, 10166, 4724, 1829, 5016, 4117, 1829, 20292, 36145, 3224, 2423, 20918, 3714, 16095, 10874, 28259, 5296, 28820, 33962, 15040, 25528, 6225, 8592, 7649, 6055, 33604, 16254, 4032, 19913, 16373, 5172, 11296, 36632, 11242, 995, 3714, 16095, 5296, 3555, 1863, 16606, 18863, 19913, 2304, 5551, 9381, 15040, 11331, 4117, 1829, 8315, 36145, 18863, 19913, 2304, 31439, 9673, 9778, 11622, 1863, 6055, 3555, 3615, 2423, 20918], "avg_logprob": -0.17583197897130792, "compression_ratio": 1.4202127659574468, "no_speech_prob": 2.980232238769531e-07, "words": [{"start": 18.1, "end": 18.86, "word": "approximately", "probability": 0.6565653483072916}, {"start": 18.86, "end": 19.38, "word": " 99", "probability": 0.83056640625}, {"start": 19.38, "end": 19.78, "word": "%", "probability": 0.94384765625}, {"start": 19.78, "end": 20.14, "word": " of", "probability": 0.91455078125}, {"start": 20.14, "end": 20.52, "word": " body", "probability": 0.86865234375}, {"start": 20.52, "end": 21.06, "word": " calcium", "probability": 0.95166015625}, {"start": 21.06, "end": 21.72, "word": " is", "probability": 0.7919921875}, {"start": 21.72, "end": 22.08, "word": " found", "probability": 0.9306640625}, {"start": 22.08, "end": 22.44, "word": " in", "probability": 0.9599609375}, {"start": 22.44, "end": 23.04, "word": " ponds", "probability": 0.423095703125}, {"start": 23.04, "end": 23.9, "word": " بيحكيلي", "probability": 0.8409016927083334}, {"start": 23.9, "end": 24.48, "word": " إنه", "probability": 0.539306640625}, {"start": 24.48, "end": 24.7, "word": " ال", "probability": 0.83642578125}, {"start": 24.7, "end": 25.16, "word": " calcium", "probability": 0.1905517578125}, {"start": 25.16, "end": 26.72, "word": " مهم", "probability": 0.989013671875}, {"start": 26.72, "end": 27.46, "word": " جدا", "probability": 0.97216796875}, {"start": 27.46, "end": 28.72, "word": " لكل", "probability": 0.855224609375}, {"start": 28.72, "end": 29.46, "word": " الخلايا", "probability": 0.9684244791666666}, {"start": 29.46, "end": 30.18, "word": " عشان", "probability": 0.9781901041666666}, {"start": 30.18, "end": 30.94, "word": " تؤدي", "probability": 0.8033854166666666}, {"start": 30.94, "end": 31.96, "word": " وظائفها", "probability": 0.9646484375}, {"start": 31.96, "end": 33.04, "word": " أيضا", "probability": 0.935546875}, {"start": 33.04, "end": 33.58, "word": " مهم", "probability": 0.99072265625}, {"start": 33.58, "end": 34.96, "word": " لبناء", "probability": 0.967529296875}, {"start": 34.96, "end": 35.72, "word": " العظم", "probability": 0.9781901041666666}, {"start": 35.72, "end": 36.98, "word": " أصلا", "probability": 0.8841145833333334}, {"start": 36.98, "end": 37.74, "word": " حكينا", "probability": 0.9739990234375}, 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"end": 46.1, "word": " ال", "probability": 0.94921875}, {"start": 46.1, "end": 46.8, "word": " rigidity", "probability": 0.760986328125}, {"start": 46.8, "end": 47.98, "word": " للعظم", "probability": 0.891845703125}, {"start": 47.98, "end": 48.86, "word": " ليش", "probability": 0.8857421875}, {"start": 48.86, "end": 49.28, "word": " العظام", "probability": 0.84375}, {"start": 49.28, "end": 49.68, "word": " حكينا", "probability": 0.8450927734375}, {"start": 49.68, "end": 50.0, "word": " rigid", "probability": 0.97216796875}, {"start": 50.0, "end": 50.78, "word": " صلبة", "probability": 0.8312174479166666}, {"start": 50.78, "end": 51.28, "word": " من", "probability": 0.5224609375}, {"start": 51.28, "end": 52.0, "word": " الأعطاها", "probability": 0.783056640625}, {"start": 52.0, "end": 52.58, "word": " الصلابة", "probability": 0.91015625}, {"start": 52.58, "end": 53.0, "word": " هذه", "probability": 0.75732421875}, {"start": 53.0, "end": 53.7, "word": " وجود", "probability": 0.9814453125}, {"start": 53.7, "end": 54.4, "word": " الكالسيوم", "probability": 0.94228515625}, {"start": 54.4, "end": 55.18, "word": " فيها", "probability": 0.9951171875}, {"start": 55.18, "end": 56.4, "word": " approximately", "probability": 0.77587890625}, {"start": 56.4, "end": 57.36, "word": " 99", "probability": 0.60595703125}, {"start": 57.36, "end": 58.04, "word": "%", "probability": 0.93212890625}, {"start": 58.04, "end": 58.8, "word": " من", "probability": 0.990234375}, {"start": 58.8, "end": 58.98, "word": " ال", "probability": 0.85693359375}, {"start": 58.98, "end": 59.32, "word": " body", "probability": 0.87060546875}, {"start": 59.32, "end": 59.98, "word": " calcium", "probability": 0.85302734375}, {"start": 59.98, "end": 60.44, "word": " is", "probability": 0.92626953125}, {"start": 60.44, "end": 60.76, "word": " found", "probability": 0.92822265625}, {"start": 60.76, "end": 61.06, "word": " in", "probability": 0.962890625}, {"start": 61.06, "end": 61.4, "word": " bones", "probability": 0.779296875}, {"start": 61.4, "end": 61.66, "word": " يعني", "probability": 0.82470703125}, {"start": 61.66, "end": 62.2, "word": " 99", "probability": 0.8759765625}, {"start": 62.2, "end": 62.6, "word": "%", "probability": 0.9833984375}, {"start": 62.6, "end": 62.94, "word": " من", "probability": 0.98828125}, {"start": 62.94, "end": 63.6, "word": " الكالسيوم", "probability": 0.95458984375}], "temperature": 1.0}, {"id": 4, "seek": 7559, "start": 64.06, "end": 75.6, "text": "اللي موجود جوات الجسم مخزن داخل العظام واحد في المية فقط هو اللي موجود في بلازما الدم، تمام؟", "tokens": [6027, 20292, 3714, 29245, 23328, 10874, 14407, 2655, 25724, 38251, 3714, 9778, 11622, 1863, 11778, 47283, 1211, 18863, 19913, 10943, 36764, 24401, 8978, 9673, 10632, 6156, 47432, 31439, 13672, 1829, 3714, 29245, 23328, 8978, 4724, 1211, 31377, 15042, 32748, 2304, 12399, 46811, 10943, 22807], "avg_logprob": -0.23211805820465087, "compression_ratio": 1.5462962962962963, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 64.06, "end": 64.4, "word": "اللي", "probability": 0.678466796875}, {"start": 64.4, "end": 64.76, "word": " موجود", "probability": 0.9889322916666666}, {"start": 64.76, "end": 65.3, "word": " جوات", "probability": 0.640380859375}, {"start": 65.3, "end": 65.84, "word": " الجسم", "probability": 0.992431640625}, {"start": 65.84, "end": 67.0, "word": " مخزن", "probability": 0.7086181640625}, {"start": 67.0, "end": 67.68, "word": " داخل", "probability": 0.9729817708333334}, {"start": 67.68, "end": 68.44, "word": " العظام", "probability": 0.94921875}, {"start": 68.44, "end": 69.7, "word": " واحد", "probability": 0.6876220703125}, {"start": 69.7, "end": 69.94, "word": " في", "probability": 0.603515625}, {"start": 69.94, "end": 70.56, "word": " المية", "probability": 0.9140625}, {"start": 70.56, "end": 71.34, "word": " فقط", "probability": 0.9853515625}, {"start": 71.34, "end": 71.7, "word": " هو", "probability": 0.884765625}, {"start": 71.7, "end": 71.96, "word": " اللي", "probability": 0.968994140625}, {"start": 71.96, "end": 72.58, "word": " موجود", "probability": 0.9876302083333334}, {"start": 72.58, "end": 73.22, "word": " في", "probability": 0.91845703125}, {"start": 73.22, "end": 74.2, "word": " بلازما", "probability": 0.5308837890625}, {"start": 74.2, "end": 75.04, "word": " الدم،", "probability": 0.8182779947916666}, {"start": 75.04, "end": 75.6, "word": " تمام؟", "probability": 0.9710286458333334}], "temperature": 1.0}, {"id": 5, "seek": 10284, "start": 76.86, "end": 102.84, "text": "الكالسيوم موجود في الدم في شكلين", "tokens": [6027, 4117, 6027, 3794, 1829, 20498, 3714, 29245, 23328, 8978, 32748, 2304, 8978, 13412, 28820, 9957], "avg_logprob": -0.5321691176470589, "compression_ratio": 1.0350877192982457, "no_speech_prob": 0.0157012939453125, "words": [{"start": 76.86, "end": 77.58, "word": "الكالسيوم", "probability": 0.8173828125}, {"start": 77.58, "end": 78.8, "word": " موجود", "probability": 0.735107421875}, {"start": 78.8, "end": 79.3, "word": " في", "probability": 0.8427734375}, {"start": 79.3, "end": 79.66, "word": " الدم", "probability": 0.695556640625}, {"start": 79.66, "end": 80.14, "word": " في", "probability": 0.4228515625}, {"start": 80.14, "end": 102.84, "word": " شكلين", "probability": 0.6277872721354166}], "temperature": 1.0}, {"id": 6, "seek": 12793, "start": 107.17, "end": 127.93, "text": "تمام؟ حر مش مربوط بأي إشي وهو هذا الشكل ال active بما أنه مش مربوط معناه هو اللي بيروح للخلايا، بدخللها عشان تؤدي وظائفها، بتطلع منها، فهو يعني هو ال free هو ال active form أو بنسميه ال ionized form", "tokens": [39237, 10943, 22807, 11331, 2288, 37893, 3714, 25513, 2407, 9566, 4724, 10721, 1829, 11933, 8592, 1829, 37037, 2407, 23758, 25124, 28820, 2423, 4967, 4724, 15042, 14739, 3224, 37893, 3714, 25513, 2407, 9566, 20449, 8315, 3224, 31439, 13672, 1829, 4724, 13546, 2407, 5016, 24976, 9778, 15040, 25528, 12399, 47525, 9778, 1211, 1211, 11296, 6225, 8592, 7649, 6055, 33604, 16254, 4032, 19913, 16373, 5172, 11296, 12399, 39894, 9566, 1211, 3615, 9154, 11296, 12399, 6156, 3224, 2407, 37495, 22653, 31439, 2423, 1737, 31439, 2423, 4967, 1254, 34051, 44945, 38251, 1829, 3224, 2423, 17437, 1602, 1254], "avg_logprob": -0.17069892088572183, "compression_ratio": 1.63, "no_speech_prob": 2.6226043701171875e-05, "words": [{"start": 107.17, "end": 108.13, "word": "تمام؟", "probability": 0.6435546875}, {"start": 108.13, "end": 108.49, "word": " حر", "probability": 0.780029296875}, {"start": 108.49, "end": 109.03, "word": " مش", "probability": 0.548828125}, {"start": 109.03, "end": 109.59, "word": " مربوط", "probability": 0.984130859375}, {"start": 109.59, "end": 109.99, "word": " بأي", "probability": 0.9222005208333334}, {"start": 109.99, "end": 110.47, "word": " إشي", "probability": 0.8849283854166666}, {"start": 110.47, "end": 111.35, "word": " وهو", "probability": 0.7415771484375}, {"start": 111.35, "end": 111.91, "word": " هذا", "probability": 0.9228515625}, {"start": 111.91, "end": 112.71, "word": " الشكل", "probability": 0.981689453125}, {"start": 112.71, "end": 113.05, "word": " ال", "probability": 0.986328125}, {"start": 113.05, "end": 113.65, "word": " active", "probability": 0.334716796875}, {"start": 113.65, "end": 114.13, "word": " بما", "probability": 0.95458984375}, {"start": 114.13, "end": 114.39, "word": " أنه", "probability": 0.696533203125}, {"start": 114.39, "end": 114.65, "word": " مش", "probability": 0.986328125}, {"start": 114.65, "end": 115.33, "word": " مربوط", "probability": 0.99072265625}, {"start": 115.33, "end": 116.01, "word": " معناه", "probability": 0.8937174479166666}, {"start": 116.01, "end": 116.17, "word": " هو", "probability": 0.97412109375}, {"start": 116.17, "end": 116.31, "word": " اللي", "probability": 0.950439453125}, {"start": 116.31, "end": 116.61, "word": " بيروح", "probability": 0.972412109375}, {"start": 116.61, "end": 117.67, "word": " للخلايا،", "probability": 0.853271484375}, {"start": 117.67, "end": 118.41, "word": " بدخللها", "probability": 0.840576171875}, {"start": 118.41, "end": 118.93, "word": " عشان", "probability": 0.9694010416666666}, {"start": 118.93, "end": 119.81, "word": " تؤدي", "probability": 0.7309977213541666}, {"start": 119.81, "end": 120.59, "word": " وظائفها،", "probability": 0.910888671875}, {"start": 120.59, "end": 120.99, "word": " بتطلع", "probability": 0.82098388671875}, {"start": 120.99, "end": 121.63, "word": " منها،", "probability": 0.9130859375}, {"start": 121.63, "end": 122.09, "word": " فهو", "probability": 0.9295247395833334}, {"start": 122.09, "end": 122.79, "word": " يعني", "probability": 0.7666015625}, {"start": 122.79, "end": 123.15, "word": " هو", "probability": 0.93212890625}, {"start": 123.15, "end": 123.61, "word": " ال", "probability": 0.80908203125}, {"start": 123.61, "end": 123.95, "word": " free", "probability": 0.7783203125}, {"start": 123.95, "end": 124.59, "word": " هو", "probability": 0.90625}, {"start": 124.59, "end": 124.79, "word": " ال", "probability": 0.9892578125}, {"start": 124.79, "end": 125.17, "word": " active", "probability": 0.91357421875}, {"start": 125.17, "end": 125.65, "word": " form", "probability": 0.9541015625}, {"start": 125.65, "end": 125.97, "word": " أو", "probability": 0.91259765625}, {"start": 125.97, "end": 126.59, "word": " بنسميه", "probability": 0.85302734375}, {"start": 126.59, "end": 126.73, "word": " ال", "probability": 0.734375}, {"start": 126.73, "end": 127.47, "word": " ionized", "probability": 0.844970703125}, {"start": 127.47, "end": 127.93, "word": " form", "probability": 0.95654296875}], "temperature": 1.0}, {"id": 7, "seek": 15402, "start": 128.86, "end": 154.02, "text": "المتأين المشحون تمام and the other و 55% من الكالسيوم اللي موجود في البلازمة هو bound كالسيوم مرتبط و على الأغلب بيكون مرتبط ببروتين و نوع هذا البروتين هو ال albumin إذاً 45% من الكالسيوم free و 55%", "tokens": [45340, 2655, 10721, 9957, 9673, 8592, 5016, 11536, 46811, 10943, 293, 264, 661, 4032, 12330, 4, 9154, 33251, 6027, 3794, 1829, 20498, 13672, 1829, 3714, 29245, 23328, 8978, 29739, 1211, 31377, 46007, 31439, 5472, 9122, 6027, 3794, 1829, 20498, 3714, 43500, 3555, 9566, 4032, 15844, 16247, 17082, 46152, 4724, 1829, 30544, 3714, 43500, 3555, 9566, 4724, 26890, 35473, 9957, 4032, 8717, 45367, 23758, 2423, 26890, 35473, 9957, 31439, 2423, 6030, 259, 11933, 15730, 14111, 6905, 4, 9154, 33251, 6027, 3794, 1829, 20498, 1737, 4032, 12330, 4], "avg_logprob": -0.18031608955613498, "compression_ratio": 1.6822916666666667, "no_speech_prob": 1.430511474609375e-06, "words": [{"start": 128.86, "end": 129.98, "word": "المتأين", "probability": 0.8590087890625}, {"start": 129.98, "end": 131.26, "word": " المشحون", "probability": 0.89794921875}, {"start": 131.26, "end": 131.88, "word": " تمام", "probability": 0.928466796875}, {"start": 131.88, "end": 133.04, "word": " and", "probability": 0.18408203125}, {"start": 133.04, "end": 133.22, "word": " the", "probability": 0.78955078125}, {"start": 133.22, "end": 133.6, "word": " other", "probability": 0.90478515625}, {"start": 133.6, "end": 134.48, "word": " و", "probability": 0.76513671875}, {"start": 134.48, "end": 134.92, "word": " 55", "probability": 0.427490234375}, {"start": 134.92, "end": 135.96, "word": "%", "probability": 0.90478515625}, {"start": 135.96, "end": 136.82, "word": " من", "probability": 0.97900390625}, {"start": 136.82, "end": 137.62, "word": " الكالسيوم", "probability": 0.857861328125}, {"start": 137.62, "end": 138.08, "word": " اللي", "probability": 0.746337890625}, {"start": 138.08, "end": 138.66, "word": " موجود", "probability": 0.9869791666666666}, {"start": 138.66, "end": 139.0, "word": " في", "probability": 0.85986328125}, {"start": 139.0, "end": 139.88, "word": " البلازمة", "probability": 0.741455078125}, {"start": 139.88, "end": 140.46, "word": " هو", "probability": 0.9140625}, {"start": 140.46, "end": 141.24, "word": " bound", "probability": 0.72900390625}, {"start": 141.24, "end": 142.24, "word": " كالسيوم", "probability": 0.94599609375}, {"start": 142.24, "end": 143.08, "word": " مرتبط", "probability": 0.9925537109375}, {"start": 143.08, "end": 143.44, "word": " و", "probability": 0.77783203125}, {"start": 143.44, "end": 143.56, "word": " على", "probability": 0.712890625}, {"start": 143.56, "end": 143.94, "word": " الأغلب", "probability": 0.8914388020833334}, {"start": 143.94, "end": 144.34, "word": " بيكون", "probability": 0.9200846354166666}, {"start": 144.34, "end": 144.82, "word": " مرتبط", "probability": 0.9951171875}, {"start": 144.82, "end": 145.48, "word": " ببروتين", "probability": 0.9130859375}, {"start": 145.48, "end": 145.86, "word": " و", "probability": 0.85009765625}, {"start": 145.86, "end": 146.06, "word": " نوع", "probability": 0.809814453125}, {"start": 146.06, "end": 146.4, "word": " هذا", "probability": 0.91748046875}, {"start": 146.4, "end": 147.0, "word": " البروتين", "probability": 0.9794921875}, {"start": 147.0, "end": 147.4, "word": " هو", "probability": 0.96337890625}, {"start": 147.4, "end": 147.6, "word": " ال", "probability": 0.87158203125}, {"start": 147.6, "end": 148.4, "word": " albumin", "probability": 0.6019287109375}, {"start": 148.4, "end": 148.94, "word": " إذاً", "probability": 0.546630859375}, {"start": 148.94, "end": 149.52, "word": " 45", "probability": 0.91796875}, {"start": 149.52, "end": 150.24, "word": "%", "probability": 0.98583984375}, {"start": 150.24, "end": 150.52, "word": " من", "probability": 0.9873046875}, {"start": 150.52, "end": 151.36, "word": " الكالسيوم", "probability": 0.92666015625}, {"start": 151.36, "end": 151.8, "word": " free", "probability": 0.62255859375}, {"start": 151.8, "end": 152.36, "word": " و", "probability": 0.98583984375}, {"start": 152.36, "end": 153.0, "word": " 55", "probability": 0.85205078125}, {"start": 153.0, "end": 154.02, "word": "%", "probability": 0.98876953125}], "temperature": 1.0}, {"id": 8, "seek": 18008, "start": 154.5, "end": 180.08, "text": "من الكالسيوم اللي موجود في بلاذ مادة بيكون 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"word": " regulate", "probability": 0.9462890625}, {"start": 465.33, "end": 465.91, "word": " serum", "probability": 0.86083984375}, {"start": 465.91, "end": 466.49, "word": " calcium", "probability": 0.970703125}, {"start": 466.49, "end": 467.05, "word": " by", "probability": 0.86865234375}, {"start": 467.05, "end": 467.83, "word": " altering", "probability": 0.909912109375}, {"start": 467.83, "end": 468.13, "word": " their", "probability": 0.94970703125}, {"start": 468.13, "end": 468.81, "word": " secretion", "probability": 0.9501953125}, {"start": 468.81, "end": 469.13, "word": " rate", "probability": 0.93896484375}, {"start": 469.13, "end": 469.49, "word": " in", "probability": 0.95068359375}, {"start": 469.49, "end": 469.99, "word": " response", "probability": 0.94091796875}, {"start": 469.99, "end": 470.23, "word": " to", "probability": 0.98095703125}, {"start": 470.23, "end": 470.81, "word": " changes", "probability": 0.58154296875}, {"start": 470.81, "end": 471.23, "word": " in", "probability": 0.935546875}, {"start": 471.23, "end": 471.89, "word": " ionized", "probability": 0.93212890625}, {"start": 471.89, "end": 472.79, "word": " calcium،", "probability": 0.74658203125}, {"start": 472.79, "end": 473.07, "word": " تلت", "probability": 0.784423828125}, {"start": 473.07, "end": 473.79, "word": " هرمونات", "probability": 0.9306640625}, {"start": 473.79, "end": 474.63, "word": " مسئولة", "probability": 0.8681640625}, {"start": 474.63, "end": 474.91, "word": " عن", "probability": 0.994140625}, {"start": 474.91, "end": 475.85, "word": " تنظيم", "probability": 0.9921875}, {"start": 475.85, "end": 477.17, "word": " مستوى", "probability": 0.968017578125}], "temperature": 1.0}, {"id": 23, "seek": 48987, "start": 478.03, "end": 489.87, "text": "الـ Ionized Calcium للـ Free Form كالسيوم في الدم تمام هم اللي بنظموا مستوى ال Ionized Calcium في الدم و هنشوف ال ميكانيزم كيف", "tokens": [6027, 39184, 286, 266, 1602, 3511, 19324, 24976, 39184, 11551, 10126, 9122, 6027, 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{"start": 501.92, "end": 502.16, "word": " لأن", "probability": 0.837646484375}, {"start": 502.16, "end": 502.48, "word": " هو", "probability": 0.82958984375}, {"start": 502.48, "end": 502.7, "word": " اللي", "probability": 0.963623046875}, {"start": 502.7, "end": 503.34, "word": " بيقدّي", "probability": 0.765185546875}, {"start": 503.34, "end": 504.56, "word": " الوظيفة", "probability": 0.98642578125}, {"start": 504.56, "end": 504.74, "word": " في", "probability": 0.9892578125}, {"start": 504.74, "end": 505.36, "word": " الجسم", "probability": 0.97509765625}, {"start": 505.36, "end": 505.8, "word": " الـ", "probability": 0.880615234375}, {"start": 505.8, "end": 506.0, "word": " Free", "probability": 0.8955078125}, {"start": 506.0, "end": 506.6, "word": " Calcium", "probability": 0.99267578125}, {"start": 506.6, "end": 507.0, "word": " اللي", "probability": 0.9736328125}, {"start": 507.0, "end": 507.2, "word": " في", "probability": 0.962890625}, {"start": 507.2, "end": 507.94, "word": 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colored complex مادة املونة و عادة اللون اللي بظهر من التفاعل لونه violet بنفس جهة", "tokens": [6027, 39184, 43183, 82, 404, 49123, 1450, 29538, 13672, 1829, 39894, 2655, 5172, 995, 30241, 20449, 33251, 6027, 3794, 1829, 20498, 2423, 39184, 44220, 533, 21677, 37495, 22653, 2423, 5480, 39894, 30544, 2423, 21677, 6055, 3555, 34268, 3224, 44220, 533, 3714, 5016, 36520, 3660, 16712, 5172, 995, 30241, 14332, 3997, 3714, 18513, 3660, 1975, 42213, 11536, 3660, 4032, 6225, 18513, 3660, 13672, 11536, 13672, 1829, 4724, 19913, 3224, 2288, 9154, 16712, 5172, 995, 30241, 5296, 11536, 3224, 46480, 44945, 36178, 10874, 3224, 3660], "avg_logprob": -0.2379092238843441, "compression_ratio": 1.598984771573604, "no_speech_prob": 3.2186508178710938e-06, "words": [{"start": 899.74, "end": 900.0, "word": "الـ", "probability": 0.385009765625}, {"start": 900.0, "end": 900.96, "word": " Chrysophthalene", "probability": 0.5786376953125}, {"start": 900.96, "end": 901.52, "word": " هذه", "probability": 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"end": 960.22, "word": " free", "probability": 0.9130859375}, {"start": 960.22, "end": 961.14, "word": " calcium", "probability": 0.9921875}, {"start": 961.14, "end": 962.18, "word": " plus", "probability": 0.7998046875}, {"start": 962.18, "end": 963.06, "word": " ال", "probability": 0.970703125}, {"start": 963.06, "end": 963.88, "word": " bound", "probability": 0.80126953125}, {"start": 963.88, "end": 964.48, "word": " calcium", "probability": 0.97998046875}, {"start": 964.48, "end": 964.8, "word": " يعني", "probability": 0.9423828125}, {"start": 964.8, "end": 965.24, "word": " بيقيث", "probability": 0.9251953125}, {"start": 965.24, "end": 965.64, "word": " كل", "probability": 0.986328125}, {"start": 965.64, "end": 966.22, "word": " الكالسيوم", "probability": 0.919140625}, {"start": 966.22, "end": 966.56, "word": " سواء", "probability": 0.9676106770833334}, {"start": 966.56, "end": 967.38, "word": " المرتبط", "probability": 0.9779052734375}, {"start": 967.38, "end": 967.76, "word": " 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"العينة Serum أو Heparinized Plasma أو 24 Hours Urine لأنه حكينا الـ Calcium ممكن يصير له Execration مع الـ urine تمام عن طريق الكدنى", "tokens": [6027, 3615, 9957, 3660, 4210, 449, 34051, 30578, 19829, 1602, 2149, 17494, 34051, 4022, 389, 5067, 9533, 533, 5296, 33456, 3224, 11331, 4117, 1829, 8315, 2423, 39184, 3511, 19324, 3714, 43020, 7251, 9381, 13546, 46740, 17662, 2405, 20449, 2423, 39184, 27638, 46811, 10943, 18871, 23032, 16572, 4587, 33251, 3215, 1863, 7578], "avg_logprob": -0.27839542294924075, "compression_ratio": 1.1635220125786163, "no_speech_prob": 0.0, "words": [{"start": 993.36, "end": 994.0, "word": "العينة", "probability": 0.8975830078125}, {"start": 994.0, "end": 994.44, "word": " Serum", "probability": 0.617431640625}, {"start": 994.44, "end": 995.18, "word": " أو", "probability": 0.8642578125}, {"start": 995.18, "end": 996.2, "word": " Heparinized", "probability": 0.6338704427083334}, {"start": 996.2, "end": 996.86, "word": " Plasma", "probability": 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"temperature": 1.0}, {"id": 60, "seek": 131578, "start": 1291.64, "end": 1315.78, "text": "الـ Oxygen هيزيد الـ CO2 هيجل هذا كله هيزود مستوى الـ pH ليش؟ لأنه بيحكيلي هينخفض مستوى الـ CO2 والـ Oxygen هيزيد وبالتالي هذا كله هذا ال reaction كله هيزود الـ pH يعني الـ pH تبع الدم هيصير تبع العينة هيصير alkaline", "tokens": [6027, 39184, 16489, 8647, 39896, 11622, 25708, 2423, 39184, 3002, 17, 39896, 7435, 1211, 23758, 28242, 3224, 39896, 11622, 23328, 3714, 14851, 2407, 7578, 2423, 39184, 21677, 32239, 8592, 22807, 5296, 33456, 3224, 4724, 1829, 5016, 4117, 1829, 20292, 39896, 1863, 9778, 5172, 11242, 3714, 14851, 2407, 7578, 2423, 39184, 3002, 17, 16070, 39184, 16489, 8647, 39896, 11622, 25708, 46599, 6027, 2655, 6027, 1829, 23758, 28242, 3224, 23758, 2423, 5480, 28242, 3224, 39896, 11622, 23328, 2423, 39184, 21677, 37495, 22653, 2423, 39184, 21677, 6055, 3555, 3615, 32748, 2304, 39896, 9381, 13546, 6055, 3555, 3615, 18863, 9957, 3660, 39896, 9381, 13546, 44220, 533], "avg_logprob": 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pH", "probability": 0.958984375}, {"start": 1311.78, "end": 1312.16, "word": " تبع", "probability": 0.9088541666666666}, {"start": 1312.16, "end": 1312.7, "word": " الدم", "probability": 0.935791015625}, {"start": 1312.7, "end": 1313.44, "word": " هيصير", "probability": 0.845703125}, {"start": 1313.44, "end": 1313.74, "word": " تبع", "probability": 0.88330078125}, {"start": 1313.74, "end": 1314.38, "word": " العينة", "probability": 0.89794921875}, {"start": 1314.38, "end": 1314.96, "word": " هيصير", "probability": 0.7489420572916666}, {"start": 1314.96, "end": 1315.78, "word": " alkaline", "probability": 0.8740234375}], "temperature": 1.0}, {"id": 61, "seek": 133643, "start": 1316.57, "end": 1336.43, "text": "مش neutral ولمّا بيصير الدم alkaline ال ionized calcium begin إذا نطلع من هذا ال slide بشغلتين في حال كان ال pH تبع الدم عند الإنسان الطبيعي in neutral متعدل هذا المقلوب مستوى ال ionized calcium بيكون طبيعي لكن", "tokens": [2304, 8592, 10598, 4032, 19528, 11703, 995, 4724, 1829, 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"end": 1406.52, "word": " عندهم", "probability": 0.99169921875}, {"start": 1406.52, "end": 1406.92, "word": " عالي", "probability": 0.9503580729166666}, {"start": 1406.92, "end": 1407.42, "word": " عشان", "probability": 0.96337890625}, {"start": 1407.42, "end": 1408.02, "word": " جسمهم", "probability": 0.9777018229166666}, {"start": 1408.02, "end": 1408.5, "word": " يبني", "probability": 0.9248046875}, {"start": 1408.5, "end": 1409.08, "word": " عشان", "probability": 0.9606119791666666}, {"start": 1409.08, "end": 1409.5, "word": " العضم", "probability": 0.9300130208333334}, {"start": 1409.5, "end": 1409.86, "word": " عندهم", "probability": 0.983642578125}, {"start": 1409.86, "end": 1410.4, "word": " ينبنع", "probability": 0.899609375}, {"start": 1410.4, "end": 1411.14, "word": " فبدهم", "probability": 0.8743489583333334}, {"start": 1411.14, "end": 1411.64, "word": " calcium", "probability": 0.72265625}, {"start": 1411.64, "end": 1412.52, "word": " أكتر", "probability": 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" هنا", "probability": 0.93994140625}, {"start": 2300.66, "end": 2301.3, "word": " بيكون", "probability": 0.8785807291666666}, {"start": 2301.3, "end": 2301.6, "word": " لونه", "probability": 0.8828125}, {"start": 2301.6, "end": 2302.06, "word": " أزرق", "probability": 0.8992919921875}, {"start": 2302.06, "end": 2302.36, "word": " اللون", "probability": 0.95458984375}, {"start": 2302.36, "end": 2302.52, "word": " اللي", "probability": 0.97314453125}, {"start": 2302.52, "end": 2302.88, "word": " بنتج", "probability": 0.8497721354166666}, {"start": 2302.88, "end": 2303.04, "word": " عن", "probability": 0.98046875}, {"start": 2303.04, "end": 2303.6, "word": " التفاعل", "probability": 0.9803466796875}, {"start": 2303.6, "end": 2304.46, "word": " أزرق", "probability": 0.986328125}, {"start": 2304.46, "end": 2305.12, "word": " تمام؟", "probability": 0.9158528645833334}], "temperature": 1.0}, {"id": 108, "seek": 232160, "start": 2305.46, "end": 2321.6, "text": "الـ Organic Phosphorus، الفسفور الموجود في الدم Reacts with molybdic acid forming a phosphomolybdic complex الموليبدك أسد هذا حمض موجود في الـ Reagent", "tokens": [6027, 39184, 12538, 299, 2623, 16378, 26867, 12399, 27188, 3794, 5172, 13063, 9673, 29245, 23328, 8978, 32748, 2304, 1300, 15295, 365, 705, 356, 65, 67, 299, 8258, 15745, 257, 19775, 298, 16453, 65, 67, 299, 3997, 9673, 12610, 1829, 3555, 3215, 4117, 5551, 3794, 3215, 23758, 11331, 2304, 11242, 3714, 29245, 23328, 8978, 2423, 39184, 1300, 559, 317], "avg_logprob": -0.3109110088671668, "compression_ratio": 1.3116883116883118, "no_speech_prob": 0.0, "words": [{"start": 2305.46, "end": 2305.84, "word": "الـ", "probability": 0.66796875}, {"start": 2305.84, "end": 2306.36, "word": " Organic", "probability": 0.64306640625}, {"start": 2306.36, "end": 2307.42, "word": " Phosphorus،", "probability": 0.65325927734375}, {"start": 2307.42, "end": 2308.16, "word": " الفسفور", "probability": 0.7958984375}, {"start": 2308.16, "end": 2309.5, "word": " الموجود", "probability": 0.9632161458333334}, {"start": 2309.5, "end": 2309.76, "word": " في", "probability": 0.98681640625}, {"start": 2309.76, "end": 2310.38, "word": " الدم", "probability": 0.9853515625}, {"start": 2310.38, "end": 2311.74, "word": " Reacts", "probability": 0.5106658935546875}, {"start": 2311.74, "end": 2312.14, "word": " with", "probability": 0.8134765625}, {"start": 2312.14, "end": 2313.16, "word": " molybdic", "probability": 0.71103515625}, {"start": 2313.16, "end": 2313.72, "word": " acid", "probability": 0.939453125}, {"start": 2313.72, "end": 2314.62, "word": " forming", "probability": 0.4375}, {"start": 2314.62, "end": 2315.32, "word": " a", "probability": 0.9375}, {"start": 2315.32, "end": 2316.46, "word": " phosphomolybdic", "probability": 0.7455240885416666}, {"start": 2316.46, "end": 2317.08, "word": " complex", "probability": 0.8974609375}, {"start": 2317.08, "end": 2318.4, "word": " الموليبدك", "probability": 0.82666015625}, {"start": 2318.4, "end": 2318.9, "word": " أسد", "probability": 0.8421223958333334}, {"start": 2318.9, "end": 2319.56, "word": " هذا", "probability": 0.56640625}, {"start": 2319.56, "end": 2320.18, "word": " حمض", "probability": 0.9763997395833334}, {"start": 2320.18, "end": 2320.74, "word": " موجود", "probability": 0.9791666666666666}, {"start": 2320.74, "end": 2320.92, "word": " في", "probability": 0.98388671875}, {"start": 2320.92, "end": 2320.98, "word": " الـ", "probability": 0.881591796875}, {"start": 2320.98, "end": 2321.6, "word": " Reagent", "probability": 0.6328531901041666}], "temperature": 1.0}, {"id": 109, "seek": 233783, "start": 2321.73, "end": 2337.83, "text": "بتفاعل مع الـ Inorganic Phosphorus اللي موجود في عينة المريض تعطيني Complex M1 it is subsequent reduction in alkaline medium originate a blue color فحصلت التفاعل اللون الأزرق", "tokens": [3555, 2655, 5172, 995, 30241, 20449, 2423, 39184, 682, 12372, 299, 2623, 16378, 26867, 13672, 1829, 3714, 29245, 23328, 8978, 6225, 9957, 3660, 9673, 16572, 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{"start": 2529.62, "end": 2530.24, "word": " خلايا", "probability": 0.9519856770833334}, {"start": 2530.24, "end": 2531.02, "word": " الكبد", "probability": 0.86083984375}, {"start": 2531.02, "end": 2532.08, "word": " حالات", "probability": 0.9622395833333334}, {"start": 2532.08, "end": 2532.28, "word": " الـ", "probability": 0.983642578125}, {"start": 2532.28, "end": 2533.68, "word": " Hepatotoxicity", "probability": 0.81982421875}, {"start": 2533.68, "end": 2534.08, "word": " caused", "probability": 0.71484375}, {"start": 2534.08, "end": 2534.42, "word": " by", "probability": 0.9892578125}, {"start": 2534.42, "end": 2534.98, "word": " drug", "probability": 0.55810546875}, {"start": 2534.98, "end": 2536.8, "word": " يعني", "probability": 0.90478515625}, {"start": 2536.8, "end": 2537.58, "word": " حدوث", "probability": 0.9765625}, {"start": 2537.58, "end": 2539.1, "word": " مشكلة", "probability": 0.9886067708333334}, {"start": 2539.1, "end": 2539.36, "word": " في", "probability": 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بدنا", "probability": 0.54864501953125}, {"start": 2724.41, "end": 2725.17, "word": " نقيصه", "probability": 0.86171875}, {"start": 2725.17, "end": 2725.55, "word": " على", "probability": 0.85205078125}, {"start": 2725.55, "end": 2725.83, "word": " الـ", "probability": 0.888671875}, {"start": 2725.83, "end": 2726.43, "word": " Spectrum", "probability": 0.597900390625}, {"start": 2726.43, "end": 2727.13, "word": " وهو", "probability": 0.77294921875}, {"start": 2727.13, "end": 2727.81, "word": " بتناسب", "probability": 0.9010416666666666}, {"start": 2727.81, "end": 2728.33, "word": " تناسب", "probability": 0.87890625}, {"start": 2728.33, "end": 2728.85, "word": " ترضي", "probability": 0.8693033854166666}, {"start": 2728.85, "end": 2729.27, "word": " مع", "probability": 0.9423828125}, {"start": 2729.27, "end": 2730.11, "word": " تركيز", "probability": 0.9947509765625}, {"start": 2730.11, "end": 2730.49, "word": " الـ", "probability": 0.828125}, {"start": 2730.49, "end": 2731.11, "word": " 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"word": " عظام", "probability": 0.9537760416666666}], "temperature": 1.0}, {"id": 135, "seek": 292156, "start": 2906.7, "end": 2921.56, "text": "هلجيت العظام تتكون من نوعين من الخلايا مش موجودة عندكم بس اننا نفهمها Osteoplast و Osteoclast Osteoplast تصل هذه الخلايا البناء للعظم و Osteoclast هذه الخلايا الهدامة للعظم", "tokens": [3224, 1211, 7435, 36081, 18863, 19913, 10943, 6055, 2655, 30544, 9154, 8717, 45367, 9957, 9154, 33962, 15040, 25528, 37893, 3714, 29245, 23328, 3660, 43242, 24793, 4724, 3794, 16472, 8315, 8717, 5172, 16095, 11296, 422, 2941, 404, 15459, 4032, 422, 2941, 905, 15459, 422, 2941, 404, 15459, 6055, 36520, 29538, 33962, 15040, 25528, 29739, 1863, 16606, 24976, 3615, 19913, 2304, 4032, 422, 2941, 905, 15459, 29538, 33962, 15040, 25528, 2423, 3224, 3215, 10943, 3660, 24976, 3615, 19913, 2304], "avg_logprob": -0.19340946085942098, "compression_ratio": 1.7756410256410255, "no_speech_prob": 4.76837158203125e-07, "words": [{"start": 2906.7, "end": 2907.46, "word": "هلجيت", "probability": 0.6827392578125}, {"start": 2907.46, "end": 2909.26, "word": " العظام", "probability": 0.9285481770833334}, {"start": 2909.26, "end": 2909.92, "word": " تتكون", "probability": 0.92919921875}, {"start": 2909.92, "end": 2910.24, "word": " من", "probability": 0.9921875}, {"start": 2910.24, "end": 2910.64, "word": " نوعين", "probability": 0.9716796875}, {"start": 2910.64, "end": 2910.76, "word": " من", "probability": 0.91357421875}, {"start": 2910.76, "end": 2911.22, "word": " الخلايا", "probability": 0.96484375}, {"start": 2911.22, "end": 2911.54, "word": " مش", "probability": 0.599609375}, {"start": 2911.54, "end": 2911.94, "word": " موجودة", "probability": 0.9827880859375}, {"start": 2911.94, "end": 2912.18, "word": " عندكم", "probability": 0.78125}, {"start": 2912.18, "end": 2912.36, "word": " بس", "probability": 0.9169921875}, {"start": 2912.36, "end": 2912.52, "word": " اننا", "probability": 0.390380859375}, {"start": 2912.52, "end": 2912.96, "word": " نفهمها", "probability": 0.9915771484375}, {"start": 2912.96, "end": 2913.76, "word": " Osteoplast", "probability": 0.658538818359375}, {"start": 2913.76, "end": 2914.02, "word": " و", "probability": 0.251953125}, {"start": 2914.02, "end": 2914.7, "word": " Osteoclast", "probability": 0.8428955078125}, {"start": 2914.7, "end": 2915.94, "word": " Osteoplast", "probability": 0.815185546875}, {"start": 2915.94, "end": 2916.36, "word": " تصل", "probability": 0.6573486328125}, {"start": 2916.36, "end": 2916.62, "word": " هذه", "probability": 0.85498046875}, {"start": 2916.62, "end": 2917.04, "word": " الخلايا", "probability": 0.978515625}, {"start": 2917.04, "end": 2917.86, "word": " البناء", "probability": 0.8758138020833334}, {"start": 2917.86, "end": 2918.42, "word": " للعظم", "probability": 0.9114990234375}, {"start": 2918.42, "end": 2918.82, "word": " و", "probability": 0.62060546875}, {"start": 2918.82, "end": 2919.48, "word": " Osteoclast", "probability": 0.8544921875}, {"start": 2919.48, "end": 2919.72, "word": " هذه", "probability": 0.87353515625}, {"start": 2919.72, "end": 2920.2, "word": " الخلايا", "probability": 0.9723307291666666}, {"start": 2920.2, "end": 2921.06, "word": " الهدامة", "probability": 0.91513671875}, {"start": 2921.06, "end": 2921.56, "word": " للعظم", "probability": 0.9903564453125}], "temperature": 1.0}, {"id": 136, "seek": 294938, "start": 2921.9, "end": 2949.38, "text": "هلجيت الـ Osteoplast هاد الخلايا جواتها في الـ ALB جواتها في الـ enzyme فعند الأطفال بيحتاج .. يعني بتكون النشط أكتر الـ Osteoplast النشطة الخلايا البناء للعضم طول ما في بناء للعضم طول ما في ان هذه الخلايا تفرز هذا الـ ALB وبالتالي بيزيد تركيزه بالدم عشان هيك عند الـ Children الـ ALB بيكون أعلى", "tokens": [3224, 1211, 7435, 36081, 2423, 39184, 422, 2941, 404, 15459, 8032, 18513, 33962, 15040, 25528, 10874, 2407, 9307, 11296, 8978, 2423, 39184, 7056, 33, 10874, 2407, 9307, 11296, 8978, 2423, 39184, 24521, 6156, 3615, 41260, 16247, 9566, 5172, 6027, 4724, 1829, 33753, 26108, 4386, 37495, 22653, 39894, 30544, 28239, 8592, 9566, 5551, 4117, 2655, 2288, 2423, 39184, 422, 2941, 404, 15459, 28239, 8592, 9566, 3660, 33962, 15040, 25528, 29739, 1863, 16606, 24976, 3615, 11242, 2304, 23032, 12610, 19446, 8978, 44945, 16606, 24976, 3615, 11242, 2304, 23032, 12610, 19446, 8978, 16472, 29538, 33962, 15040, 25528, 6055, 5172, 2288, 11622, 23758, 2423, 39184, 7056, 33, 46599, 6027, 2655, 6027, 1829, 4724, 1829, 11622, 25708, 6055, 31747, 1829, 11622, 3224, 20666, 40448, 6225, 8592, 7649, 39896, 4117, 43242, 2423, 39184, 13354, 2423, 39184, 7056, 33, 4724, 1829, 30544, 5551, 3615, 23942], "avg_logprob": -0.16153326630592346, "compression_ratio": 1.9484126984126984, "no_speech_prob": 4.172325134277344e-07, "words": [{"start": 2921.9, "end": 2922.3, "word": "هلجيت", "probability": 0.6533203125}, {"start": 2922.3, "end": 2922.6, "word": " الـ", "probability": 0.946044921875}, {"start": 2922.6, "end": 2923.42, "word": " Osteoplast", "probability": 0.79888916015625}, {"start": 2923.42, "end": 2923.84, "word": " هاد", "probability": 0.4635009765625}, {"start": 2923.84, "end": 2924.52, "word": " الخلايا", "probability": 0.7854817708333334}, {"start": 2924.52, "end": 2925.44, "word": " جواتها", "probability": 0.77099609375}, {"start": 2925.44, "end": 2925.68, "word": " في", "probability": 0.96142578125}, {"start": 2925.68, "end": 2926.0, "word": " الـ", "probability": 0.89111328125}, {"start": 2926.0, "end": 2926.6, "word": " ALB", "probability": 0.779052734375}, {"start": 2926.6, "end": 2927.7, "word": " جواتها", "probability": 0.875244140625}, {"start": 2927.7, "end": 2928.0, "word": " في", "probability": 0.98779296875}, {"start": 2928.0, "end": 2928.44, "word": " الـ", "probability": 0.8134765625}, {"start": 2928.44, "end": 2928.86, "word": " enzyme", "probability": 0.455322265625}, {"start": 2928.86, "end": 2929.64, "word": " فعند", "probability": 0.9454752604166666}, {"start": 2929.64, "end": 2930.36, "word": " الأطفال", "probability": 0.9962158203125}, {"start": 2930.36, "end": 2931.08, "word": " بيحتاج", "probability": 0.7376708984375}, {"start": 2931.08, "end": 2931.12, "word": " ..", "probability": 0.352783203125}, {"start": 2931.12, "end": 2931.34, "word": " يعني", "probability": 0.89111328125}, {"start": 2931.34, "end": 2932.08, "word": " بتكون", "probability": 0.859375}, {"start": 2932.08, "end": 2932.9, "word": " النشط", "probability": 0.93701171875}, {"start": 2932.9, "end": 2933.38, "word": " أكتر", "probability": 0.970703125}, {"start": 2933.38, "end": 2933.64, "word": " الـ", "probability": 0.87158203125}, {"start": 2933.64, "end": 2934.4, "word": " Osteoplast", "probability": 0.9215087890625}, {"start": 2934.4, "end": 2935.32, "word": " النشطة", "probability": 0.97509765625}, {"start": 2935.32, "end": 2936.1, "word": " الخلايا", "probability": 0.728759765625}, {"start": 2936.1, "end": 2936.84, "word": " البناء", "probability": 0.85986328125}, {"start": 2936.84, "end": 2937.82, "word": " للعضم", "probability": 0.8499755859375}, {"start": 2937.82, "end": 2938.16, "word": " طول", "probability": 0.980712890625}, {"start": 2938.16, "end": 2938.28, "word": " ما", "probability": 0.9814453125}, {"start": 2938.28, "end": 2938.48, "word": " في", "probability": 0.92333984375}, {"start": 2938.48, "end": 2938.96, "word": " بناء", "probability": 0.94482421875}, {"start": 2938.96, "end": 2939.8, "word": " للعضم", "probability": 0.9329833984375}, {"start": 2939.8, "end": 2940.1, "word": " طول", "probability": 0.9091796875}, {"start": 2940.1, "end": 2940.26, "word": " ما", "probability": 0.984375}, {"start": 2940.26, "end": 2940.58, "word": " في", "probability": 0.9306640625}, {"start": 2940.58, "end": 2941.06, "word": " ان", "probability": 0.347412109375}, {"start": 2941.06, "end": 2941.36, "word": " هذه", "probability": 0.53076171875}, {"start": 2941.36, "end": 2941.78, "word": " الخلايا", "probability": 0.98193359375}, {"start": 2941.78, "end": 2942.4, "word": " تفرز", "probability": 0.899658203125}, {"start": 2942.4, "end": 2942.68, "word": " هذا", "probability": 0.88330078125}, {"start": 2942.68, "end": 2942.9, "word": " الـ", "probability": 0.915771484375}, {"start": 2942.9, "end": 2943.3, "word": " ALB", "probability": 0.968994140625}, {"start": 2943.3, "end": 2943.8, "word": " وبالتالي", "probability": 0.9009765625}, {"start": 2943.8, "end": 2944.22, "word": " بيزيد", "probability": 0.9466552734375}, {"start": 2944.22, "end": 2944.88, "word": " تركيزه", "probability": 0.9806640625}, {"start": 2944.88, "end": 2945.66, "word": " بالدم", "probability": 0.8955078125}, {"start": 2945.66, "end": 2946.0, "word": " عشان", "probability": 0.9267578125}, {"start": 2946.0, "end": 2946.24, "word": " هيك", "probability": 0.981201171875}, {"start": 2946.24, "end": 2946.5, "word": " عند", "probability": 0.94677734375}, {"start": 2946.5, "end": 2946.64, "word": " الـ", "probability": 0.831787109375}, {"start": 2946.64, "end": 2947.16, "word": " Children", "probability": 0.48681640625}, {"start": 2947.16, "end": 2947.72, "word": " الـ", "probability": 0.931640625}, {"start": 2947.72, "end": 2948.12, "word": " ALB", "probability": 0.9677734375}, {"start": 2948.12, "end": 2948.68, "word": " بيكون", "probability": 0.9278971354166666}, {"start": 2948.68, "end": 2949.38, "word": " أعلى", "probability": 0.9239908854166666}], "temperature": 1.0}, {"id": 137, "seek": 295287, "start": 2949.95, "end": 2952.87, "text": "و بهيك خلصنا ال chapter و يعطيكم العافية", "tokens": [2407, 39627, 1829, 4117, 16490, 1211, 9381, 8315, 2423, 7187, 4032, 37495, 9566, 1829, 24793, 18863, 31845, 10632], "avg_logprob": -0.09482935855263158, "compression_ratio": 0.9428571428571428, "no_speech_prob": 0.0, "words": [{"start": 2949.95, "end": 2950.23, "word": "و", "probability": 0.67578125}, {"start": 2950.23, "end": 2950.81, "word": " بهيك", "probability": 0.8582356770833334}, {"start": 2950.81, "end": 2951.39, "word": " خلصنا", "probability": 0.9696044921875}, {"start": 2951.39, "end": 2951.49, "word": " ال", "probability": 0.81787109375}, {"start": 2951.49, "end": 2951.79, "word": " chapter", "probability": 0.93017578125}, {"start": 2951.79, "end": 2951.93, "word": " و", "probability": 0.94482421875}, {"start": 2951.93, "end": 2952.35, "word": " يعطيكم", "probability": 0.9151611328125}, {"start": 2952.35, "end": 2952.87, "word": " العافية", "probability": 0.97900390625}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2953.57825, "duration_after_vad": 2894.874093749995}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/u4q3JwIsRVo_raw.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/u4q3JwIsRVo_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..bcdfe8d2803c7aecd8ae1f9b3dc65043ffb88d46
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/u4q3JwIsRVo_raw.srt
@@ -0,0 +1,2396 @@
+1
+00:00:00,000 --> 00:00:05,180
+بدنا نحكي عن ال bone profile test الفحصات اللى
+
+2
+00:00:05,180 --> 00:00:11,260
+بتشيك على وضع العظام أول فحص هو ال calcium calcium
+
+3
+00:00:11,260 --> 00:00:16,760
+is required for cell function overall and for bone
+
+4
+00:00:16,760 --> 00:00:21,720
+metabolismapproximately 99% of body calcium is
+
+5
+00:00:21,720 --> 00:00:28,720
+found in ponds بيحكيلي إنه ال calcium مهم جدا لكل
+
+6
+00:00:28,720 --> 00:00:35,720
+الخلايا عشان تؤدي وظائفها أيضا مهم لبناء العظم
+
+7
+00:00:35,720 --> 00:00:42,060
+أصلا حكينا إن العظم هو المخزن تبع ال calciumتمام
+
+8
+00:00:42,060 --> 00:00:47,980
+فالكالسيوم هو المسؤول عن إعطاء ال rigidity للعظم
+
+9
+00:00:47,980 --> 00:00:52,580
+ليش العظام حكينا rigid صلبة من الأعطاها الصلابة
+
+10
+00:00:52,580 --> 00:00:58,980
+هذه وجود الكالسيوم فيها approximately 99% من ال
+
+11
+00:00:58,980 --> 00:01:02,940
+body calcium is found in bones يعني 99% من
+
+12
+00:01:02,940 --> 00:01:08,440
+الكالسيوماللي موجود جوات الجسم مخزن داخل العظام
+
+13
+00:01:08,440 --> 00:01:15,040
+واحد في المية فقط هو اللي موجود في بلازما الدم،
+
+14
+00:01:15,040 --> 00:01:42,840
+تمام؟الكالسيوم موجود في الدم في شكلين
+
+15
+00:01:47,170 --> 00:01:53,650
+تمام؟ حر مش مربوط بأي إشي وهو هذا الشكل ال active
+
+16
+00:01:53,650 --> 00:01:57,670
+بما أنه مش مربوط معناه هو اللي بيروح للخلايا،
+
+17
+00:01:57,670 --> 00:02:03,150
+بدخللها عشان تؤدي وظائفها، بتطلع منها، فهو يعني هو
+
+18
+00:02:03,150 --> 00:02:07,470
+ال free هو ال active form أو بنسميه ال ionized
+
+19
+00:02:07,470 --> 00:02:16,820
+formالمتأين المشحون تمام and the other و 55% من
+
+20
+00:02:16,820 --> 00:02:22,240
+الكالسيوم اللي موجود في البلازمة هو bound كالسيوم
+
+21
+00:02:22,240 --> 00:02:26,400
+مرتبط و على الأغلب بيكون مرتبط ببروتين و نوع هذا
+
+22
+00:02:26,400 --> 00:02:31,800
+البروتين هو ال albumin إذاً 45% من الكالسيوم free
+
+23
+00:02:31,800 --> 00:02:38,040
+و 55%من الكالسيوم اللي موجود في بلاذ مادة بيكون
+
+24
+00:02:38,040 --> 00:02:42,960
+مرتبط ببروتين اسمه الـ albumin وهذا المرتبط عادة
+
+25
+00:02:42,960 --> 00:02:49,180
+ما بيكون مشحون تمام؟ لأن شحنته اتعدلت مثلا هو كان
+
+26
+00:02:49,180 --> 00:02:53,160
+موجب وال albumin سالب ربطوا في بعض وبالتالي بطل
+
+27
+00:02:53,160 --> 00:02:58,040
+مشحون inactive form يعني بما انه ارتبط معناه مش
+
+28
+00:02:58,040 --> 00:03:04,650
+هيقدر يؤدي وظيفتهبنسميه الـ Bound أو الـ Inactive
+
+29
+00:03:04,650 --> 00:03:12,760
+Form الـ Form اللي مش نشطهذا الـ slide كتير مهمة
+
+30
+00:03:12,760 --> 00:03:17,340
+too little calcium gets you either a loss of
+
+31
+00:03:17,340 --> 00:03:22,140
+tissue function or soft ponds osteoporosis بيقصد
+
+32
+00:03:22,140 --> 00:03:28,320
+فيها لو كانت نسبة الكالسيوم جواة العظم كانت قليلة
+
+33
+00:03:28,320 --> 00:03:35,390
+هذا هيؤدي إلىإحداث الـ Soft Bones هتصبح العظام هشة
+
+34
+00:03:35,390 --> 00:03:40,770
+سهلة الكثر يعني بيصير عندي osteoporesis هشاشة عظام
+
+35
+00:03:40,770 --> 00:03:45,650
+وهذه حالة مرضية طبعا إذا في حال نقص الكالسيوم في
+
+36
+00:03:45,650 --> 00:03:49,450
+المخزن يعني نقص مستوى الكالسيوم في الـ bones في
+
+37
+00:03:49,450 --> 00:03:53,030
+العظام اتفاجن الكالسيوم هو اللي يعطي الـrigidity
+
+38
+00:03:53,030 --> 00:03:58,880
+الصلابة للعظم فلو نقص الكالسيوم هتصبح العظامسهلة
+
+39
+00:03:58,880 --> 00:04:04,660
+الكسر soft bone عظام ناعمة وهشة osteoporosis حالة
+
+40
+00:04:04,660 --> 00:04:11,090
+مرضية نقصد فيها هشاشة عظامwhile too much gives you
+
+41
+00:04:11,090 --> 00:04:16,630
+titanic cardiac arrest and or lockjaw is from over
+
+42
+00:04:16,630 --> 00:04:21,290
+clinching of muscles or over brittle bones إيش
+
+43
+00:04:21,290 --> 00:04:26,170
+بيقصد في الشق الآخر؟ الشق الآخر عكس الأول الشق
+
+44
+00:04:26,170 --> 00:04:32,250
+الآخر بيحكي لو مستوى الكالسيوم كان في ال bonesأعلى
+
+45
+00:04:32,250 --> 00:04:37,370
+من الحد المسموح يعني عالي كتير كتير احنا حكينا هو
+
+46
+00:04:37,370 --> 00:04:41,270
+موجود بكميات كبيرة في ال bones ولكن لو زاد عن هذه
+
+47
+00:04:41,270 --> 00:04:48,910
+الكميات هيؤدي ذلك إلى تصلب العظم يعني العظم يعني
+
+48
+00:04:48,910 --> 00:04:54,170
+على الرغم من انه rigid صلب لكن مرن بتحرك لكن في
+
+49
+00:04:54,170 --> 00:05:00,380
+حالزاد مستوى الكالسيوم وكان أكتر من الطبيعي جوات
+
+50
+00:05:00,380 --> 00:05:04,860
+الـ Bones راح يؤدي إلى التتاناص حيصاب الشخص
+
+51
+00:05:04,860 --> 00:05:09,420
+بتتاناص في عضلاته ممكن يصير عنده cardiac arrest
+
+52
+00:05:09,420 --> 00:05:16,220
+توقف عضلة القلب نتيجة ارتفاع مستوى الكالسيوم ممكن
+
+53
+00:05:16,220 --> 00:05:24,430
+يصير عنده lock jaw يعنيفك أثنانه بيبطل يتحرك اللي
+
+54
+00:05:24,430 --> 00:05:29,770
+هو مرض الكزاز بنحكي عنه الـ Tetanus هذا كله إيش
+
+55
+00:05:29,770 --> 00:05:34,290
+سببه؟ is from over clinching of muscles هذا سببه
+
+56
+00:05:34,290 --> 00:05:43,930
+إن العضلات يعني صار فيهاانقباض مستمر وجهدات العظام
+
+57
+00:05:43,930 --> 00:05:47,890
+والعضلات تفاجنا إنه لما بتكون الـ Calcium أعلى من
+
+58
+00:05:47,890 --> 00:05:52,310
+الحد الطبيعي في الـ Bones بتصير العضلة يعني خلاص
+
+59
+00:05:52,310 --> 00:05:57,270
+مش جادرة تتحرك رجد كتير، ثلبة كتير كتير ممكن الشخص
+
+60
+00:05:57,270 --> 00:06:03,110
+يصير عنده الـ Titanus نتيجة الانقباض المستمر
+
+61
+00:06:03,110 --> 00:06:10,380
+للعضلة ويعني انقباض فوق الطبيعيطبعا هذا المقصود
+
+62
+00:06:10,380 --> 00:06:13,800
+إذا من هذه الفقرة بتفهم شغلتان لو جال مستوى ال
+
+63
+00:06:13,800 --> 00:06:19,740
+calcium في العضم العضم بيصير هش بنكسر لكن بيصير
+
+64
+00:06:19,740 --> 00:06:24,860
+عندي osteoporosis هشاشة عضان لكن لو ال calcium زاد
+
+65
+00:06:24,860 --> 00:06:30,260
+مستوى في العضم أكتر من الطبيعي بيصير عندي تشنش في
+
+66
+00:06:30,260 --> 00:06:34,900
+العضم بيصير عندي تيتانوس يصاب الشخص بالتيتانوس
+
+67
+00:06:34,900 --> 00:06:41,270
+طبعا okayChains in calcium are used to assess bond
+
+68
+00:06:41,270 --> 00:06:47,850
+function أي تغير في مستوى الكالسيوم هذا مهم جدا
+
+69
+00:06:47,850 --> 00:06:53,680
+وبيعبر عن وظيفة الـ bondHigher blood levels
+
+70
+00:06:53,680 --> 00:06:59,500
+usually mean lower bone levels بيحكيلي عادة لو كان
+
+71
+00:06:59,500 --> 00:07:04,880
+مستوى الكالسيوم في الدم عالي عالي كتير أعلى من
+
+72
+00:07:04,880 --> 00:07:09,720
+الطبيعي هذا بيعبر أن مستوى الكالسيوم في ال bone
+
+73
+00:07:09,720 --> 00:07:17,020
+بدأ يقل أو حيقل تمام؟Usually performed in
+
+74
+00:07:17,020 --> 00:07:20,600
+conjugation with phosphorus determination عادة ما
+
+75
+00:07:20,600 --> 00:07:24,400
+بنعمل فحص الكالسوم لحاله دايما كالسوم و فوسفورس مع
+
+76
+00:07:24,400 --> 00:07:29,400
+بعض عشان نشيك على وضع الـBond Three hormones،
+
+77
+00:07:29,400 --> 00:07:33,900
+تلاتة هرمونات الـparathyroid hormone هرمونات
+
+78
+00:07:33,900 --> 00:07:39,150
+الغضدجاردرقيةVitamin DL والـ Calcitonin هذا
+
+79
+00:07:39,150 --> 00:07:42,570
+الهرمون بتتم إفرازه من الغدة الدراقية نفسها من الـ
+
+80
+00:07:42,570 --> 00:07:46,490
+thyroid gland are known to regulate serum calcium
+
+81
+00:07:46,490 --> 00:07:50,230
+by altering their secretion rate in response to
+
+82
+00:07:50,230 --> 00:07:54,910
+changes in ionized calcium، تلت هرمونات مسئولة عن
+
+83
+00:07:54,910 --> 00:08:01,110
+تنظيم مستوىالـ Ionized Calcium للـ Free Form
+
+84
+00:08:01,110 --> 00:08:05,990
+كالسيوم في الدم تمام هم اللي بنظموا مستوى ال
+
+85
+00:08:05,990 --> 00:08:09,870
+Ionized Calcium في الدم و هنشوف ال ميكانيزم كيف
+
+86
+00:08:11,380 --> 00:08:18,100
+الركز مع بعض من الرسمة بيحكيلي لما مستوى الـ
+
+87
+00:08:18,100 --> 00:08:21,500
+Ionized Calcium أنا بهمنه الـ Free Calcium يا
+
+88
+00:08:21,500 --> 00:08:26,000
+جماعة لأن هو اللي بيقدّي الوظيفة في الجسم الـ Free
+
+89
+00:08:26,000 --> 00:08:31,000
+Calcium اللي في البلازمة تبعت الدم لما بيقل مستوى
+
+90
+00:08:31,000 --> 00:08:40,710
+الـ Ionized Calcium في بلازمة الدم هذا إشارةلا الـ
+
+91
+00:08:40,710 --> 00:08:45,710
+Parathyroid gland إنها تقوم بإفراز الـ Parathyroid
+
+92
+00:08:45,710 --> 00:08:49,730
+hormone إذن الـ Parathyroid gland الغُدّ
+
+93
+00:08:49,730 --> 00:08:54,170
+الجاردرقية تستشعر في إنه في نقص في الـ Ionized
+
+94
+00:08:54,170 --> 00:08:59,010
+calcium في بلازمة الدم فبتقوم بإفراز هرمون اسمه
+
+95
+00:08:59,010 --> 00:09:03,570
+الـ Parathyroid hormone هذا لما بيتم إفرازه لو
+
+96
+00:09:03,570 --> 00:09:09,320
+تبعته على الصورةلما بيتم إفرازه إلى two-receptor
+
+97
+00:09:09,320 --> 00:09:13,680
+بيشتغل يعني على ممتقتين أو على أدوين في الجسم هذا
+
+98
+00:09:13,680 --> 00:09:20,100
+الهورمون بيروح بيشتغل على الـ bone على العظم
+
+99
+00:09:20,100 --> 00:09:26,110
+وبيحفظالـ Calcium اللي موجود في الـ bone إنه يطلع
+
+100
+00:09:26,110 --> 00:09:31,710
+لبرا يطلع على الدم يعني من المخزن للدم عشان يزيد
+
+101
+00:09:31,710 --> 00:09:35,890
+مستوى الـ Ionized Calcium إذن أول شغل للـ
+
+102
+00:09:35,890 --> 00:09:41,190
+Parathyroid hormone إنها بتروح على الـ bone لأنه
+
+103
+00:09:41,190 --> 00:09:44,850
+هو المخزن للكالسيوم وأنا بحاجة في الدم للكالسيوم
+
+104
+00:09:44,850 --> 00:09:50,430
+وبيصير الـ bone يطلع كالسيوم من عنده إلى إبلازمة
+
+105
+00:09:50,430 --> 00:09:56,870
+الدم، تمام؟وال action التاني .. الشغل التاني للـ
+
+106
+00:09:56,870 --> 00:10:00,530
+Parathyroid hormone أنه بيروح على الكلا
+
+107
+00:10:03,030 --> 00:10:08,430
+بحفظ الكيلة إنها تعمل Reabsorption للكالسيون،
+
+108
+00:10:08,430 --> 00:10:11,410
+الكيلة وظّفتها تطلّع الشغلات اللي بدنا نشيها و
+
+109
+00:10:11,410 --> 00:10:15,350
+ترجع الشغلات اللي بدّيها، فهو بحفظ الكيلة تعمل
+
+110
+00:10:15,350 --> 00:10:20,730
+إعادة انتصاص للـIonized Calcium وترجعه إلى البلازم
+
+111
+00:10:20,730 --> 00:10:24,170
+الدم لأنه أنا بدياه، لأنه فعليا الشخص هذا صار عنده
+
+112
+00:10:24,170 --> 00:10:29,180
+نقص في الـIonized Calciumمش بس هيك الكيلة بتعمل
+
+113
+00:10:29,180 --> 00:10:34,020
+أيضًا الـ Parathyroid hormone بحفظ الكيلة إنها
+
+114
+00:10:34,020 --> 00:10:39,800
+تكمل .. اتكمل في تصنيع Vitamin Dالتفاجنة إنه
+
+115
+00:10:39,800 --> 00:10:44,400
+Vitamin Dال بتصنع في ال liver وبيتم اكمال تصنيعه
+
+116
+00:10:44,400 --> 00:10:48,430
+في ال kidney في الكبت صح ولا لأ؟في الـ kidney، في
+
+117
+00:10:48,430 --> 00:10:53,070
+الكلة، صح ولا لأ؟ إذن الـ Parathyroid hormone كمان
+
+118
+00:10:53,070 --> 00:10:58,550
+بتحفظ الكلة إنها تكمل تصنيع Vitamin DL إذن Vitamin
+
+119
+00:10:58,550 --> 00:11:04,490
+DL اتصنع و تمام و صار active Vitamin DL إيش بيعمل؟
+
+120
+00:11:04,490 --> 00:11:12,000
+Vitamin DL بيحفظ إعادة انتصاف الكالسيومعبر الـ
+
+121
+00:11:12,000 --> 00:11:17,960
+intestine تمام؟ بمنع ال calcium يخرج مع ال stool
+
+122
+00:11:17,960 --> 00:11:24,560
+صح ولا لا؟ فبحفظ ال vitamin D بشتغل على ال
+
+123
+00:11:24,560 --> 00:11:30,060
+intestine الأمعاءوبيحفظ الأمعاء تعمل Reabsorption
+
+124
+00:11:30,060 --> 00:11:35,140
+للكالسيوم تعمله إعادة انتصاص و ترجعه للدم ومايخرجش
+
+125
+00:11:35,140 --> 00:11:38,620
+مع ال stool أنا ما بدي أعمل Execration له بالعكس
+
+126
+00:11:38,620 --> 00:11:42,480
+الدم ال ionized calcium فيه قليل فانا بدي أرجعه
+
+127
+00:11:42,480 --> 00:11:48,960
+للدم تمام؟ إذا هذه كل ال mechanism هذا عشان أذود
+
+128
+00:11:48,960 --> 00:11:52,840
+مستوى ال ionized calcium في الدم تمام؟
+
+129
+00:11:57,180 --> 00:12:04,560
+أما الشق الأخرفي حال ارتفع الـ ionized calcium
+
+130
+00:12:04,560 --> 00:12:08,160
+عندى فى الدم ارتفع عن الوضع الطبيعى الإنسان
+
+131
+00:12:08,160 --> 00:12:11,640
+الطبيعى لازم يكون ضمن range معين ال calcium عنده
+
+132
+00:12:11,640 --> 00:12:15,360
+ال ionized calcium فلو انخفط حكينا ايش بيصير مين
+
+133
+00:12:15,360 --> 00:12:19,960
+بيشتغل الـ parathyroid hormone لكن لو ارتفع مستوى
+
+134
+00:12:19,960 --> 00:12:24,060
+ال ionized calcium فى الدم انا بدي مين ينزله تمام
+
+135
+00:12:24,060 --> 00:12:30,090
+فالشق الاخر بيحكي لي لو ارتفعمستوى الـ Ionized
+
+136
+00:12:30,090 --> 00:12:38,130
+كالسيوم في الدم مين هيشتغل؟ لما بيرتفع اللي هيتحسس
+
+137
+00:12:38,130 --> 00:12:41,950
+بهذا الارتفاع الـ Thyroid gland الغضب الدراقية
+
+138
+00:12:41,950 --> 00:12:47,910
+نفسها وتقوم بإفراز الـ Calcitonin هذا هرمون يفرز
+
+139
+00:12:47,910 --> 00:12:51,610
+من الغضب الدراقية برضه يا جماعة الـ Calcitonin
+
+140
+00:12:51,610 --> 00:12:56,530
+بشتغل على موقعين زي و زي الـ Parathyroid hormone
+
+141
+00:12:57,460 --> 00:13:03,100
+بشتغل على العظم وبشتغل على الـ kidneyبشتغل على
+
+142
+00:13:03,100 --> 00:13:07,100
+العضم وإيش بيحفظ زي ما هو مكتوب بالـ slide
+
+143
+00:13:07,100 --> 00:13:12,460
+Simulates calcium deposition in bones يمنع خروج
+
+144
+00:13:12,460 --> 00:13:18,020
+الكالسيوم من الـ bone للدم لأن الدم أصلا مليان
+
+145
+00:13:18,020 --> 00:13:23,360
+ionized calcium فبديش ionized calcium بزيادة فبمنع
+
+146
+00:13:23,360 --> 00:13:27,100
+بحفظ الـ deposition للكالسيوم يعني بيخلي الكالسيوم
+
+147
+00:13:27,100 --> 00:13:31,360
+في الـ bone وممنوع يطلع للدمعكس شغل الـ
+
+148
+00:13:31,360 --> 00:13:36,220
+Parathyroid hormone إذا منتبهين و أيضًا بيشتغل الـ
+
+149
+00:13:36,220 --> 00:13:40,340
+Calcitonin على الـ kidney و إيش بيعمل للـ kidney؟
+
+150
+00:13:40,340 --> 00:13:45,920
+و بيحفظ الكيلة تعمل Execration للكالسيوم بحفظ
+
+151
+00:13:45,920 --> 00:13:49,960
+للكيلة تتخلص من الكالسيوم عن طريق الـ urine و
+
+152
+00:13:49,960 --> 00:13:54,240
+ممنوع تعمله Reabsorption و بهيك ترجع مستوى الـ
+
+153
+00:13:54,240 --> 00:13:58,680
+Ionized Calcium في الدم طبيعيتمام؟ إذا اللي بنظّم
+
+154
+00:13:58,680 --> 00:14:02,460
+مستوى الكالسيوم في الدم البارا تايرويد هرمون
+
+155
+00:14:02,460 --> 00:14:07,580
+هرمونات الغدة الجاردراقية و الـ Calcitonin اللي
+
+156
+00:14:07,580 --> 00:14:11,460
+بيفرز من الغدة الدراقية و برضه vitamin ده العبارة
+
+157
+00:14:11,460 --> 00:14:18,340
+عن هرمون في الآخر صنفه برضه مسئول عن تنظيم مستوى
+
+158
+00:14:18,340 --> 00:14:22,740
+الكالسيوم في الدم تمام؟ إذا هذه تلت هرمونات بتنظم
+
+159
+00:14:22,740 --> 00:14:27,190
+مستوى الكالسيوم في الدمالـ Principle of the Method
+
+160
+00:14:27,190 --> 00:14:31,650
+مبدأ طريقتنا Calorimetric Reaction الكالسيوم بروح
+
+161
+00:14:31,650 --> 00:14:35,870
+يتفاعل مع مادة موجودة في الـReagent محصلة التفاعل
+
+162
+00:14:35,870 --> 00:14:39,530
+اعطاء مادة ملونة بالقيس شدة هاد المادة
+
+163
+00:14:39,530 --> 00:14:44,800
+والـabsorbance تبعها على جهاز الـSpectraمقارنة
+
+164
+00:14:44,800 --> 00:14:48,940
+الكالسيوم في المجلد تعتمد على صناعة مجلد ألوان
+
+165
+00:14:48,940 --> 00:14:54,100
+كمplex بين كالسيوم و أورثو كريزوفاتالين في مجلد
+
+166
+00:14:54,100 --> 00:14:57,620
+ألكولايين ميديا ري أجينت اللي بيجي من الشركة يحتوي
+
+167
+00:14:57,620 --> 00:15:01,620
+على مادة الأورثوالـ Chrysophthalene هذه اللي
+
+168
+00:15:01,620 --> 00:15:06,220
+بتتفاعل مع الكالسيوم الـ alkaline pH يعني ال
+
+169
+00:15:06,220 --> 00:15:12,040
+reaction بتكون ال pH تبعته alkaline محصلة التفاعل
+
+170
+00:15:12,040 --> 00:15:17,920
+colored complex مادة املونة و عادة اللون اللي بظهر
+
+171
+00:15:17,920 --> 00:15:22,270
+من التفاعل لونه violet بنفس جهةالـ Ortho
+
+172
+00:15:22,270 --> 00:15:26,510
+-chrysophthalene complex one gives violet color in
+
+173
+00:15:26,510 --> 00:15:29,810
+alkaline medium في الآخر اتحاد الكالسيوم مع هذه
+
+174
+00:15:29,810 --> 00:15:34,310
+المادة باعطين اللون الـ violet the intensity of
+
+175
+00:15:34,310 --> 00:15:37,790
+the color formed is proportional to the calcium
+
+176
+00:15:37,790 --> 00:15:43,240
+concentration in the sample شدة اللونتتناسب تناسب
+
+177
+00:15:43,240 --> 00:15:48,700
+ترضي مع تركيز الكالسيوم في العينة كمان شغلة ال kit
+
+178
+00:15:48,700 --> 00:15:53,560
+اللي عندي في المختبر بيقيث ال total calcium يعني
+
+179
+00:15:53,560 --> 00:15:56,740
+إيش يعني total calcium؟ يعني بيقيث ال total
+
+180
+00:15:56,740 --> 00:16:00,220
+calcium في ال plasma الدم يعني بيقيث ال free
+
+181
+00:16:00,220 --> 00:16:05,640
+calcium plus ال bound calcium يعني بيقيث كل
+
+182
+00:16:05,640 --> 00:16:11,040
+الكالسيوم سواء المرتبط أو الغير مرتبطأيضاً في
+
+183
+00:16:11,040 --> 00:16:16,500
+عيننا كتات بتقيث فقط الـ Ionized Calcium الجزء الـ
+
+184
+00:16:16,500 --> 00:16:19,580
+Free الكالسيوم الحر تمام؟ هذه الشيءة بدنا ناخدها
+
+185
+00:16:19,580 --> 00:16:26,380
+بعين الاعتبار ال
+
+186
+00:16:26,380 --> 00:16:31,080
+specimen العينة لو بدنا نفحص ال total calcium أو
+
+187
+00:16:31,080 --> 00:16:36,200
+ال ionized calciumالعينة Serum أو Heparinized
+
+188
+00:16:36,200 --> 00:16:39,920
+Plasma أو 24 Hours Urine لأنه حكينا الـ Calcium
+
+189
+00:16:39,920 --> 00:16:44,400
+ممكن يصير له Execration مع الـ urine تمام عن طريق
+
+190
+00:16:44,400 --> 00:16:49,040
+الكدنىSeparation from cells are rapidly as
+
+191
+00:16:49,040 --> 00:16:51,880
+possible to avoid the uptake of calcium by
+
+192
+00:16:51,880 --> 00:16:55,980
+erythrocyte يعني هذه الجملة خلاص فهمناها ال
+
+193
+00:16:55,980 --> 00:16:59,660
+calcium زي و زي السكر يعني لما بتصلني العينة بسرعة
+
+194
+00:16:59,660 --> 00:17:04,320
+بدي أفصل ال serum عن خلايا الدم الحامرة لأنه لو
+
+195
+00:17:04,320 --> 00:17:08,320
+دلهم contact مع بعض هتصير خلايا الدم الحامرة تسحب
+
+196
+00:17:08,320 --> 00:17:11,160
+في ال calcium شوي شوي زي ما كانت تتسحب في السكر
+
+197
+00:17:11,160 --> 00:17:15,630
+لأنه خلايا بتقوم بأعماليات حيويةفتحتاج الكالسيوم
+
+198
+00:17:15,630 --> 00:17:19,790
+في عملياتها فهتظلها تصحي بالكالسيوم وهذا الأمر
+
+199
+00:17:19,790 --> 00:17:24,030
+مرفوض يعني بسرعة بدنا ن center العينة ونفصل الـ
+
+200
+00:17:24,030 --> 00:17:30,070
+Serum عن خلايا الدم الحمرةVenus Stasis هذا المصطلح
+
+201
+00:17:30,070 --> 00:17:34,090
+أخدناه قبل هيك تعريفه prolong tourniquet
+
+202
+00:17:34,090 --> 00:17:38,690
+application إنك تبقى رابط المربط اللي هو
+
+203
+00:17:38,690 --> 00:17:42,510
+tourniquet قبل ما تيجي تسحب الدم لفترة طويلة يعني
+
+204
+00:17:42,510 --> 00:17:46,590
+أربط ال tourniquet و بعدين أحضر أدواتي هذا الأمر
+
+205
+00:17:46,590 --> 00:17:52,080
+أكيد مرفوض طيب لو أنت عملت هيك إيش هيصير؟and
+
+206
+00:17:52,080 --> 00:17:57,200
+forearm exercise يعني لو انت طولت وانت رابط ال
+
+207
+00:17:57,200 --> 00:18:02,400
+tourniquet هاي شغلة ومش بس هيك لو الشخص كان مثلا
+
+208
+00:18:02,400 --> 00:18:07,740
+عامل مجهود عضلي في إيده اللي بدي يسحب منها جاب
+
+209
+00:18:07,740 --> 00:18:12,060
+العملية السحب يعني مجهد عضلات الإيد كلها هذه
+
+210
+00:18:12,060 --> 00:18:16,720
+الشغلات إيش ممكن تسوي؟ هتعمل زيادة في ال ionized
+
+211
+00:18:16,720 --> 00:18:22,680
+calcium ليش؟هل جيت إجهاد العضلة أو ربط الـ
+
+212
+00:18:22,680 --> 00:18:25,680
+tourniquet ما نفس الأشياء انت اما تربطي تربط ال
+
+213
+00:18:25,680 --> 00:18:31,020
+tourniquet فترة طويلة على الإيد هيصير في إجهاد
+
+214
+00:18:31,020 --> 00:18:36,520
+العضلات هتجهد، هتتعب، تمام؟ هذا التعب هيؤدي إلى
+
+215
+00:18:36,520 --> 00:18:41,760
+خفض الـ pH تبع الدم كلنا عارفين أن الـ pH تبع الدم
+
+216
+00:18:41,760 --> 00:18:49,040
+عند الإنسان الطبيعي إنيوترال من 7.3 ل7.4، تمام؟لكن
+
+217
+00:18:49,040 --> 00:18:53,700
+في حال إنسان عمل مجهود عضلي زيادة عن اللزوم سواء
+
+218
+00:18:53,700 --> 00:18:56,760
+في عضلات الجسم كلها أو هنا بيحكي عن عضلة الإيد
+
+219
+00:18:56,760 --> 00:19:00,740
+اللي بنسحب منها أو ربطنة تورنكت وبالتالي تورنكت
+
+220
+00:19:00,740 --> 00:19:06,760
+هيأثر على عضلات الإيد طيبهذه الشغلات إيش هتعمل
+
+221
+00:19:06,760 --> 00:19:11,820
+بيحكيلي هتخفض مستوى الـ pH في الدم بدل ما يكون
+
+222
+00:19:11,820 --> 00:19:17,080
+neutral متعادل ممكن يصير بما إنه هيتخفض الـ pH
+
+223
+00:19:17,080 --> 00:19:23,280
+ممكن يصير acidic pH وهذه حالة مرضية ليش؟ لأنه إذا
+
+224
+00:19:23,280 --> 00:19:28,360
+أخدتوها بالحيوية لما نجهد العضلة أو نشتغل مجهود في
+
+225
+00:19:28,360 --> 00:19:35,360
+مجهود عضلي جبار بتتكون مادة الـ lactic acidأو الـ
+
+226
+00:19:35,360 --> 00:19:40,120
+Lactic Acid أو الـ Lactate صح ولا لأ؟ هذه المادة
+
+227
+00:19:40,120 --> 00:19:45,420
+تتكون بكميات أكبر من الطبيعي إذا انت عملت مجهود
+
+228
+00:19:45,420 --> 00:19:49,740
+عضلي وجود هذه المادة، دي مادة حنضية وجودها في الدم
+
+229
+00:19:49,740 --> 00:19:55,440
+already هيخفض من مستوى الـ pH بسرعة بتأثر على
+
+230
+00:19:55,440 --> 00:20:00,390
+مستوى الـ pH الـ pH هيكون neutralلو انت عملت مجهود
+
+231
+00:20:00,390 --> 00:20:05,090
+عضلي هتتكون مادة اسمها الـ Lactic Acid هذه المادة
+
+232
+00:20:05,090 --> 00:20:10,430
+الحنضية هتخفض مستوى الـ pH ويصير الـ pH أثدك تمام؟
+
+233
+00:20:11,610 --> 00:20:18,110
+ولمّا يصير الـ pH أثيدك بيحكيلي هذا بيزود مستوى ال
+
+234
+00:20:18,110 --> 00:20:23,610
+ionized calcium في الدم إذا الـ venous stasis ربط
+
+235
+00:20:23,610 --> 00:20:27,630
+التورنيكات فترة طويلة ال forearm exercise عمل
+
+236
+00:20:27,630 --> 00:20:31,810
+مجهود كل هذه الشغلات هتزود مستوى ال ionized
+
+237
+00:20:31,810 --> 00:20:37,080
+calcium بشكل خاطئ في الدم إيش السبب؟صار في عندي
+
+238
+00:20:37,080 --> 00:20:43,540
+decrease in pH قلي الـ pH تبع الدم ليش؟ بسبب إنتاج
+
+239
+00:20:43,540 --> 00:20:48,340
+الـ Lactic Acid في العضلة في العضلة بيصير نتيجة
+
+240
+00:20:48,340 --> 00:20:54,420
+إجهادها بتتكون مادة حنضية اسمها الـ Lactic Acid هي
+
+241
+00:20:54,420 --> 00:20:59,380
+اللي بتنزل الـ pH وبالتالي هذا بيؤدي إلى رفع مستوى
+
+242
+00:20:59,380 --> 00:21:03,880
+الـ Ionized Calcium في الدم واضح؟ هذه شغلات بدنا
+
+243
+00:21:03,880 --> 00:21:09,190
+نتجنبهاExposing the sample to air will cause an
+
+244
+00:21:09,190 --> 00:21:13,570
+increase in pH إن العكس بيحكي لي لو سحبت عينة من
+
+245
+00:21:13,570 --> 00:21:19,810
+شخص وعربت العينة لـair لهوة لفترة طويلة يعني دايما
+
+246
+00:21:19,810 --> 00:21:26,290
+بدنا نسكر ال tube تبعت السحب لو عربت ال sample
+
+247
+00:21:26,290 --> 00:21:32,520
+للهوة معناه في oxygen أكتر من الـCO2الـ Oxygen
+
+248
+00:21:32,520 --> 00:21:40,500
+هيزيد الـ CO2 هيجل هذا كله هيزود مستوى الـ pH ليش؟
+
+249
+00:21:40,500 --> 00:21:45,200
+لأنه بيحكيلي هينخفض مستوى الـ CO2 والـ Oxygen
+
+250
+00:21:45,200 --> 00:21:49,360
+هيزيد وبالتالي هذا كله هذا ال reaction كله هيزود
+
+251
+00:21:49,360 --> 00:21:54,960
+الـ pH يعني الـ pH تبع الدم هيصير تبع العينة هيصير
+
+252
+00:21:54,960 --> 00:22:01,370
+alkalineمش neutral ولمّا بيصير الدم alkaline ال
+
+253
+00:22:01,370 --> 00:22:05,310
+ionized calcium begin إذا نطلع من هذا ال slide
+
+254
+00:22:05,310 --> 00:22:09,950
+بشغلتين في حال كان ال pH تبع الدم عند الإنسان
+
+255
+00:22:09,950 --> 00:22:13,590
+الطبيعي in neutral متعدل هذا المقلوب مستوى ال
+
+256
+00:22:13,590 --> 00:22:19,030
+ionized calcium بيكون طبيعي لكنلو انخفض الـ pH
+
+257
+00:22:19,030 --> 00:22:22,610
+يعني صار الـ pH أسدك وهذه حالة مرضية أي إنسان
+
+258
+00:22:22,610 --> 00:22:26,410
+بيكون عنده الـ pH تبع الدم أسدك حالة مرضية صعبة
+
+259
+00:22:26,410 --> 00:22:33,090
+لما بيصير الدم أسدك الـ ionized calcium بيزيد لما
+
+260
+00:22:33,090 --> 00:22:38,930
+بيصير الدم alkaline يعني الـ pH عالية ال ionized
+
+261
+00:22:38,930 --> 00:22:42,370
+calcium مستوى في الدم بيجل تمام؟
+
+262
+00:22:46,300 --> 00:22:51,960
+طبعا الـ Normal Range للكالسيوم عند الـ Normal
+
+263
+00:22:51,960 --> 00:22:55,560
+Range هنا قصده الـ Total Calcium انتبهوا الـ
+
+264
+00:22:55,560 --> 00:22:59,700
+Normal Range لـ Total Calcium الـ Ionized ذائد الـ
+
+265
+00:22:59,700 --> 00:23:05,440
+Bound عند الـ Adult من 8.5 ل 10.5 milligram per
+
+266
+00:23:05,440 --> 00:23:09,040
+deciliter فححوا اللي عندكم، عندكم بالـ slide مكتوب
+
+267
+00:23:09,040 --> 00:23:13,440
+microgram، No الكالسيوم بتم قياسه بالmilligram per
+
+268
+00:23:13,440 --> 00:23:18,900
+deciliterعند ال children من عشرة لاطنعش milligram
+
+269
+00:23:18,900 --> 00:23:23,340
+per DC لتر ملاحظين أعلى من ال adult مستوى ال total
+
+270
+00:23:23,340 --> 00:23:27,420
+calcium عندهم لأنه أصلا لازم يكون عندهم عالي عشان
+
+271
+00:23:27,420 --> 00:23:31,640
+جسمهم يبني عشان العضم عندهم ينبنع فبدهم calcium
+
+272
+00:23:31,640 --> 00:23:36,960
+أكتر تمام؟ لو بدي أحولها بال micro mole per liter
+
+273
+00:23:36,960 --> 00:23:43,660
+زي ما احنا شايفينحالات بيصير فيها hypocalcemia
+
+274
+00:23:43,660 --> 00:23:49,340
+يعني انخفاض مستوى هنا بيقصد الـ ionized calcium في
+
+275
+00:23:49,340 --> 00:23:53,360
+الدم الـ hypocalcemia معناه في عندي انخفاض في
+
+276
+00:23:53,360 --> 00:23:58,240
+مستوى ال ionized calcium في الدم متى بيصير هذا؟
+
+277
+00:23:58,880 --> 00:24:02,960
+بيصير عندما يكون عندى vitamin Dالـdeficiency لو
+
+278
+00:24:02,960 --> 00:24:06,420
+عندى تفاجنا vitamin Dالإيش بيعمل؟ هو اللى بيحفظ
+
+279
+00:24:06,420 --> 00:24:11,360
+الأمعاق تعمل إعادة انتصاص للكالسوم وتمنع خروجه عبر
+
+280
+00:24:11,360 --> 00:24:15,540
+الستول فلو مافيشش vitamin Dالمعناه الكالسوم
+
+281
+00:24:15,540 --> 00:24:21,220
+هيصيرله خروج مع الستول ويقل مستوى معناه هيصير عندى
+
+282
+00:24:21,220 --> 00:24:26,870
+high bcalcemiaالـ Hypoparathyroidism يعني انخفاض
+
+283
+00:24:26,870 --> 00:24:32,370
+مستوى هرمون البارا ثيرويد هرمون لما بتجل البارا
+
+284
+00:24:32,370 --> 00:24:36,470
+ثيرويد هرمون اتفجنا انسان صار عنده انخفاض في ال
+
+285
+00:24:36,470 --> 00:24:41,080
+ionized calciumلو هو طبيعي، الـ Parathyroid هرمون
+
+286
+00:24:41,080 --> 00:24:45,000
+إيش وظيفتها؟ تروح للكلة، تحكي لها اعمل إعادة
+
+287
+00:24:45,000 --> 00:24:49,200
+انتصاف، اتروح للـ bone، اطلع الكالسيوم من الـ bone
+
+288
+00:24:49,200 --> 00:24:53,620
+للدم، لكن لو أنت أصلا عندك Hypoparathyroidism،
+
+289
+00:24:53,620 --> 00:24:57,240
+يعني عندك انخفاض أصلا في الهرمون، معناه ال action
+
+290
+00:24:57,240 --> 00:25:01,860
+تبع هذا الهرمون مش هيصير، معناه هيضل الجسم يعاني
+
+291
+00:25:01,860 --> 00:25:07,960
+من الـ Hypocalcemiaحالات الـ Alkalosis أو الكيميا
+
+292
+00:25:07,960 --> 00:25:11,580
+الـ Alkalemia
+
+293
+00:25:11,580 --> 00:25:17,040
+أو الـ Alkalosis اللي هو ارتفاع الـ pH تبع الدم
+
+294
+00:25:17,040 --> 00:25:22,520
+الأشخاص اللي عندهم الـ pH عالي مش neutral هدول
+
+295
+00:25:22,520 --> 00:25:26,540
+الأشخاص بيكون عندهم نقص في الـ Ionized Calcium زي
+
+296
+00:25:26,540 --> 00:25:30,380
+ما حكيناها بالـ slide اللي جابل تمام أما الـ
+
+297
+00:25:30,380 --> 00:25:34,160
+Hypercalcemiaالرتفاع مستوى الـ Ionized Calcium في
+
+298
+00:25:34,160 --> 00:25:39,000
+الدم عدة أسباب Hyperparathyroidism يعني الـ
+
+299
+00:25:39,000 --> 00:25:43,220
+Parathyroid هرمون الـ action يعني الهرمون موجود
+
+300
+00:25:43,220 --> 00:25:48,300
+بكميات كتير كبيرة أكتر من الطبيعي Hyper وبالتالي
+
+301
+00:25:48,300 --> 00:25:51,860
+هيشتغل على ال kilo و هيشتغل على ال bone بشكل أكبر
+
+302
+00:25:51,860 --> 00:25:56,980
+هيطلع ال calcium من ال bone للدمهيروح للكلة يعطيها
+
+303
+00:25:56,980 --> 00:26:01,200
+أوامر إعادة امتصاص للكالسيوم دايما وبالتالي إيش
+
+304
+00:26:01,200 --> 00:26:05,220
+المحصلة هيزيد مستوى ال ionized calcium Malignancy
+
+305
+00:26:05,220 --> 00:26:10,200
+of bone سرطانات في ال bone هيؤدي ذلك إلى تسرب
+
+306
+00:26:10,200 --> 00:26:13,960
+الكالسيوم من ال bone إلى ال blood هيطلع الكالسيوم
+
+307
+00:26:13,960 --> 00:26:19,680
+من العضم إلى الدم في حالة ال malignancyالـ
+
+308
+00:26:19,680 --> 00:26:23,540
+Thyrotoxicosis Thyrotoxicosis وجود .. هتاخدوا هذه
+
+309
+00:26:23,540 --> 00:26:28,180
+المصطلحات في كورس الهرمونات وجود مشكلة في الـ
+
+310
+00:26:28,180 --> 00:26:32,480
+Thyroid hormone Thyroid hormone ترتفع أكتر من
+
+311
+00:26:32,480 --> 00:26:37,260
+الطبيعي إذا سمعتوا عنهم الـ T3 و T4 تمام؟ طب إيش
+
+312
+00:26:37,260 --> 00:26:43,210
+دخلهم؟بحُكم أنه الغُدّة الدرقية جنب الغُدّة
+
+313
+00:26:43,210 --> 00:26:47,430
+الجاردرقية هما جنب بعيد موجودين فلما بيصير عندي
+
+314
+00:26:47,430 --> 00:26:50,690
+مشكلة بالغُدّة الدرقية already هتأثر على الغُدّة
+
+315
+00:26:50,690 --> 00:26:55,430
+التانية الجاردرقية هذه جثة الـthyrotoxicosis برضه
+
+316
+00:26:55,430 --> 00:26:58,670
+في الـthyrotoxicosis مش هرمونات الغُدّة الدرقية بس
+
+317
+00:26:58,670 --> 00:27:02,670
+بترتفع لهم T3 وT4 برضه الـparathyroid hormone
+
+318
+00:27:02,670 --> 00:27:07,430
+هيرتفع يعني هيصير عندي sorry هيصير عنديالـ
+
+319
+00:27:07,430 --> 00:27:12,020
+HyperparathyroidismVitamin D Intoxication إيش
+
+320
+00:27:12,020 --> 00:27:16,400
+يعني؟ يعني Vitamin D موجود بتركيز عالي جدا جدا
+
+321
+00:27:16,400 --> 00:27:19,840
+أعلى من الطبيعي وهذا التركيز بيكون toxic يعني ممكن
+
+322
+00:27:19,840 --> 00:27:25,220
+يموت الإنسان أو يدمر عنده أنسجة معينة فلما بيزيد
+
+323
+00:27:25,220 --> 00:27:29,820
+برضه Vitamin D التفاجنة هيحفظ الأمعاق بشكل مضاعف
+
+324
+00:27:29,820 --> 00:27:34,040
+تعمل إعادة إمتصاص لكالسيوم ممكن يكون حالات اديوبثك
+
+325
+00:27:34,040 --> 00:27:38,540
+مجهولة بتأدي لزيادة مستوى ال ionized calcium في
+
+326
+00:27:38,540 --> 00:27:41,710
+الدمالسلام عليكم و رحمه اللهنجي للفحص التاني
+
+327
+00:27:41,710 --> 00:27:46,210
+الفوسفوريس فوسفوريس is an essential mineral for
+
+328
+00:27:46,210 --> 00:27:50,010
+tissue bone formation and is required by every
+
+329
+00:27:50,010 --> 00:27:53,730
+cell in the body for normal function فوسفوريس من
+
+330
+00:27:53,730 --> 00:27:58,030
+العناصر المعدنية المهمة اللي بتحتاجها جميع الخلايا
+
+331
+00:27:58,030 --> 00:28:04,410
+من أجل أداء وظيفها أيضا عشان ال bone formation لما
+
+332
+00:28:04,410 --> 00:28:09,990
+بيصير إنه تكوين عظام أيضا الفوسفوريس بتحتاج العظام
+
+333
+00:28:10,110 --> 00:28:17,430
+من أجل تكوينها، تمام؟approximately حوالي 85% من ال
+
+334
+00:28:17,430 --> 00:28:21,550
+body phosphorus is found in bone and in teeth خمسة
+
+335
+00:28:21,550 --> 00:28:26,410
+و تمانين في المية من ال phosphorus مخزن جواة العظم
+
+336
+00:28:26,410 --> 00:28:30,990
+مع ال calcium هو ال calcium مشيين مع بعض مخزن داخل
+
+337
+00:28:30,990 --> 00:28:35,030
+ال bone و في ال teeth أيضا و في الأسنان ال low
+
+338
+00:28:35,030 --> 00:28:39,290
+levels of phosphorus يعني انخفاض مستوى ال
+
+339
+00:28:39,290 --> 00:28:45,370
+phosphorus في الدمCan be caused by مين بيسببه الـ
+
+340
+00:28:45,370 --> 00:28:50,150
+Hypervitaminosis Primary Hyperparathyroidism Renal
+
+341
+00:28:50,150 --> 00:28:54,310
+Tupular Disorder الـ Antacid أو الـ Malabsorption
+
+342
+00:28:54,310 --> 00:28:57,890
+بتكون تركزوا معي شغلتين شوية بعاد عن الكلام هذا
+
+343
+00:28:59,050 --> 00:29:05,130
+بتكونوا تعرفوا إن Vitamin Dال إتفجنا إنه بيحفظ
+
+344
+00:29:05,130 --> 00:29:10,470
+إعادة إمتصاص الكالسيوم، صح ولا لأ؟ أيضًا شغله مع
+
+345
+00:29:10,470 --> 00:29:15,170
+الفوسفورس نفس الكلام Vitamin Dال بيشتغل على
+
+346
+00:29:15,170 --> 00:29:22,530
+الأنعاقوبيحفظ الأمعاء أيضًا تعمل إعادة امتصاص لـ
+
+347
+00:29:22,530 --> 00:29:26,750
+Phosphorus على الدم وممنوع يطلع برا الستول يعني
+
+348
+00:29:26,750 --> 00:29:31,910
+ممنوع يطلع مع الستول، تمام؟ إذا شغل Vitamin D لـ
+
+349
+00:29:31,910 --> 00:29:36,370
+Phosphorus وكالسيوم زي بعض إنه بيصير لهم إعادة
+
+350
+00:29:36,370 --> 00:29:41,430
+امتصاص، تمام؟ أما الـ Parathyroid hormone هذه
+
+351
+00:29:41,430 --> 00:29:41,950
+الغدة
+
+352
+00:29:45,230 --> 00:29:49,250
+البراتيرويد هرمون هذا الهرمون اتفجنا انه بيشتغل
+
+353
+00:29:49,250 --> 00:29:53,990
+على البون وبيشتغل على الكلة شغله على الكلة انه
+
+354
+00:29:53,990 --> 00:30:00,010
+يعمل إعادة امتصاص للكالسيوم صح ولا لا؟لكن شغله مع
+
+355
+00:30:00,010 --> 00:30:04,870
+الفوسفور مختلف شغله مع الفوسفور إنه بيحفظ الـ
+
+356
+00:30:04,870 --> 00:30:09,450
+Parathyroid hormone بيحفظ الكيلة تعمل Execration
+
+357
+00:30:09,450 --> 00:30:15,070
+للفوسفور تمام؟ برا تترضه مع الـ urine إذا شغل
+
+358
+00:30:15,070 --> 00:30:20,090
+vitamin D للكالسيوم والفوسفور واحد وشغل ال
+
+359
+00:30:20,090 --> 00:30:27,000
+Parathyroid hormoneوشغل الـ Parathyroid هرمون
+
+360
+00:30:27,000 --> 00:30:32,280
+للفوسفورث والكالسيوم عكس بعد بتطلع الكالسيوم برا
+
+361
+00:30:32,280 --> 00:30:39,160
+الجسم مع اليورين وبتحفظ الكلا شغل ال Parathyroid
+
+362
+00:30:39,160 --> 00:30:43,720
+هرمون على الكلا انه بتحكي للكلا اعملي اعادة امتصاص
+
+363
+00:30:43,720 --> 00:30:49,400
+للكالسيوم واعملي execution للفوسفورث مع اليورين
+
+364
+00:30:49,400 --> 00:30:56,550
+تمام؟إذن بينخفض مستوى الفوسفور في الدم لو صار عندي
+
+365
+00:30:56,550 --> 00:31:02,670
+Hypervitaminosis طب كيف؟ هتحكولي إن Vitamin D
+
+366
+00:31:02,670 --> 00:31:08,770
+بالعكس بعمل إعادة انتصاف للفوسفور و بيرجعه على
+
+367
+00:31:08,770 --> 00:31:14,860
+الدم صحيح هذا الوضع الطبيعي لكن لو ذات Vitamin Dعن
+
+368
+00:31:14,860 --> 00:31:21,440
+حده يعني صار intoxication يعني وصل لـ dose لجرعة
+
+369
+00:31:21,440 --> 00:31:26,080
+السمية في الجسم hypervitaminosis يعني عالي كتير
+
+370
+00:31:26,080 --> 00:31:30,540
+كتير هيحفظ الأمعاق تعمل execution للـ phosphorus
+
+371
+00:31:30,540 --> 00:31:35,080
+مع الستول، تمام؟ لكن هو الطبيعي بيعمله إعادة
+
+372
+00:31:35,080 --> 00:31:39,380
+امتصاص، لكن لو زاد مستوى للـ vitamin دال، هيعمل
+
+373
+00:31:39,380 --> 00:31:44,270
+شغل عكس شغله الطبيعيPrimary Hyperparathyroidism
+
+374
+00:31:44,270 --> 00:31:49,430
+يعني حدوث ارتفاع في الـ Parathyroid هرمون بشكل
+
+375
+00:31:49,430 --> 00:31:53,290
+هائل، Hyper هذه الحالة اتفجنا، ما ال Parathyroid
+
+376
+00:31:53,290 --> 00:31:57,750
+هرمون إيش بتعمل؟ بتعمل Execration للفسفور مع
+
+377
+00:31:57,750 --> 00:32:01,270
+اليورين وبالتالي لو زاد هذا الهرمون، معناه ال
+
+378
+00:32:01,270 --> 00:32:06,010
+Execration هيزيد وبالتالي هيقل مستوى الفسفور في
+
+379
+00:32:06,010 --> 00:32:11,780
+الدم لأنه في هرمون بحفظ خروجه برا الجسمRenal
+
+380
+00:32:11,780 --> 00:32:16,560
+Tupular Disorder مشاكل في لتيوبيول تبعت الكلة مش
+
+381
+00:32:16,560 --> 00:32:21,040
+جادرة لتيوبيول تعمل إعادة انتصاص وبالتالي بتطلع
+
+382
+00:32:21,040 --> 00:32:24,640
+الفوسفور لبرا مع ال urine الناس اللي بتاخد Anti
+
+383
+00:32:24,640 --> 00:32:29,940
+Acid تاخد الأدوية ضد الحموضةبرضه هذه بتخفض مستوى
+
+384
+00:32:29,940 --> 00:32:33,280
+الفسفور في الدم أو الـmal absorption أكيد شخص عنده
+
+385
+00:32:33,280 --> 00:32:38,740
+سوء امتصاص فعالفاضي إيش ما ياكل وإيش ما يشرب مش
+
+386
+00:32:38,740 --> 00:32:45,000
+هيصير عنده امتصاص للشغلة وإعادة إرجاع تمام؟high
+
+387
+00:32:45,000 --> 00:32:49,180
+levels of phosphorus أما ارتفاع مستوى الفوسفور في
+
+388
+00:32:49,180 --> 00:32:53,960
+الدم can be caused by إذا أنت أكلت أكلات مليانة
+
+389
+00:32:53,960 --> 00:32:58,840
+فوسفور أكيد هيرتفع المستوى البون ميتاستاسز حدوث
+
+390
+00:32:58,840 --> 00:33:04,790
+كانسر في البونحكيتلكم هيتسرب .. هتتسرب المعادن
+
+391
+00:33:04,790 --> 00:33:07,350
+الموجود في ال .. موجودة في الـ bone الكالسيوم و
+
+392
+00:33:07,350 --> 00:33:10,750
+الفوسفور الاتنين هيطلعوا لبرا، هيطلعوا للدم
+
+393
+00:33:10,750 --> 00:33:14,250
+وبالتالي هيزيد تركيزهم في الدم حالات الـ liver
+
+394
+00:33:14,250 --> 00:33:17,770
+disease، حالات الـ alcohol ingestion، حالات
+
+395
+00:33:17,770 --> 00:33:21,670
+الدياريا، ال vomiting، دي كلها dehydration، جفاف،
+
+396
+00:33:21,670 --> 00:33:26,130
+معناه هيتركز المعادن في بلازم الدمClinical
+
+397
+00:33:26,130 --> 00:33:29,150
+diagnosis shouldn't be made on a single test
+
+398
+00:33:29,150 --> 00:33:33,830
+result عشان أنا أشخص ممنوع نتيجة فحص واحد it
+
+399
+00:33:33,830 --> 00:33:36,470
+should integrate clinical and other laboratory
+
+400
+00:33:36,470 --> 00:33:41,410
+data بدنا أكتر من فحص نعمله مع بعض عشان نشيك على
+
+401
+00:33:41,410 --> 00:33:47,570
+وضع أي عضو في الجسمالـ Regulation تنظيم الفوسفورس
+
+402
+00:33:47,570 --> 00:33:51,770
+الـ phosphate in blood maybe هلجت الفوسفور اتفجنا
+
+403
+00:33:51,770 --> 00:33:57,110
+انه 85% منه موجودة في البون والجزء المتبقي موجود
+
+404
+00:33:57,110 --> 00:34:03,030
+في بلاذم الدم تمام؟هل جيت الفوسفيت اللي موجود سواء
+
+405
+00:34:03,030 --> 00:34:06,410
+فوسفيت أو فوسفورس نفس المصطلح الفوسفيت اللي موجود
+
+406
+00:34:06,410 --> 00:34:10,530
+في الدم من وين مصدره absorbed in the intestine
+
+407
+00:34:10,530 --> 00:34:15,150
+from dietary sources أول مصدر الأكل إنسان بياكل
+
+408
+00:34:15,150 --> 00:34:20,150
+أكلات مليانة فوسفور الأنعاق بيصير في انتصاص لهذا
+
+409
+00:34:20,150 --> 00:34:25,890
+الأكل الأنعاق هتعمل إعادة انتصاصللفسفور هذا اللي
+
+410
+00:34:25,890 --> 00:34:30,050
+موجود في الأكل و ترجعه للدم تمام؟ إذا عرفنا
+
+411
+00:34:30,050 --> 00:34:34,190
+الفسفور اللي موجود في الدم مصدره من الـ diet من
+
+412
+00:34:34,190 --> 00:34:39,590
+الأكلممكن الفسفور released from cells into blood
+
+413
+00:34:39,590 --> 00:34:44,830
+في خلايا معينة ممكن يكون جواها موجود الفسفور فممكن
+
+414
+00:34:44,830 --> 00:34:48,670
+يطلع من هذه الخلايا إلى الدم and lost from bone
+
+415
+00:34:48,670 --> 00:34:53,010
+برضه الفسفور اللي موجود في الدم ممكن يكون مصدره من
+
+416
+00:34:53,010 --> 00:34:58,730
+البون إن البون بدأت تسرب فسفور و تطلع للدم تمام؟
+
+417
+00:34:59,450 --> 00:35:05,230
+إذا مصادره من الأكل والأمعاء ودته للدم من خلايا
+
+418
+00:35:05,230 --> 00:35:09,270
+أخرى غير خلايا الأمعاء ومن الـ bone هذا مصادر
+
+419
+00:35:09,270 --> 00:35:12,550
+الفوسفور الموجود في الدم in healthy individuals
+
+420
+00:35:12,550 --> 00:35:16,290
+عند الناس الطبيعيين all these processes are
+
+421
+00:35:16,290 --> 00:35:19,870
+relatively constant and easily regulated by هذه
+
+422
+00:35:19,870 --> 00:35:23,890
+التلت عمليات اللي أنا حكيتها إنه بناكله والأمعاء
+
+423
+00:35:23,890 --> 00:35:28,490
+بتعملوا إعادة امتصاصخروج الفسفور من وإلى الخلايا
+
+424
+00:35:28,490 --> 00:35:33,210
+فقده من الـ bone هذه عمليات طبيعية بتسير في الجسم
+
+425
+00:35:33,210 --> 00:35:39,390
+وعمليات منظمة بصيرلها regulation تمام؟ومين بيعملها
+
+426
+00:35:39,390 --> 00:35:42,750
+ال regulation أول إيش الكلا؟ يعني الرينا ال
+
+427
+00:35:42,750 --> 00:35:46,850
+execution في حال أنا بديش فسفور زيادة في الدم إيش
+
+428
+00:35:46,850 --> 00:35:51,450
+بتعمل الكلا؟ بتعمل execution لهذا الفسفور عن طريق
+
+429
+00:35:51,450 --> 00:35:54,410
+ال urine بتطلعه مع ال urine يعني لازم يصير فيه
+
+430
+00:35:54,410 --> 00:36:00,300
+تنظيم أو reabsorption أو ممكن لو أنا بديالفوسفور
+
+431
+00:36:00,300 --> 00:36:04,480
+محتاجة فوسفور ممكن الأمعاء تعمل إعادة انتصاص ممكن
+
+432
+00:36:04,480 --> 00:36:08,940
+الكلا تعمل إعادة انتصاص إذا حسب حازة الجسم الكلا
+
+433
+00:36:08,940 --> 00:36:15,040
+بتشتغل تمام؟الـ Regulation، تنظيم مستوى الفوسفور
+
+434
+00:36:15,040 --> 00:36:20,720
+في الدم حكيناها، لخصهم عجباً Vitamin DL بيعمل
+
+435
+00:36:20,720 --> 00:36:26,220
+إعادة انتصاص للفوسفور، تمام؟ أول إشي Vitamin DL
+
+436
+00:36:26,220 --> 00:36:29,700
+اللي أصله بيتصنع هو في الكلا، تمام؟ في الـ kidney
+
+437
+00:36:29,700 --> 00:36:33,860
+Vitamin DL بشتغل على الأمعاء و بيخلل الأمعاء تعمل
+
+438
+00:36:33,860 --> 00:36:39,310
+إعادة انتصاص للفوسفور وترجعه للدم، تمام؟أما الـ
+
+439
+00:36:39,310 --> 00:36:44,990
+Parathyroid hormone بيشتغل على الكلة وبيحكي للكلة
+
+440
+00:36:44,990 --> 00:36:50,750
+اعمل execution للفسفور إذا نقرأ رينال ريجوليشن is
+
+441
+00:36:50,750 --> 00:36:55,030
+affected by factors such as يعني الكلة و تنظيمات
+
+442
+00:36:55,030 --> 00:36:59,050
+الكلة بتتأثر بشغلتين بالفيتاميندال و بال
+
+443
+00:36:59,050 --> 00:37:03,370
+Parathyroid hormoneIncreases both phosphate
+
+444
+00:37:03,370 --> 00:37:06,770
+absorption in the intestine and phosphate
+
+445
+00:37:06,770 --> 00:37:09,090
+reabsorption in the kidney
+
+446
+00:37:13,510 --> 00:37:19,490
+بشتغل على الأمعاء وعلى الانتستان وبعمل إعادة
+
+447
+00:37:19,490 --> 00:37:23,470
+انتصاص للفوسفات وبالتالي تركيز الفوسفات هيزيد في
+
+448
+00:37:23,470 --> 00:37:28,490
+الدم وأيضا Vitamin Dال بشتغل على الكيلة وبحفظ
+
+449
+00:37:28,490 --> 00:37:32,630
+الكيلة تعمل إعادة انتصاص للفوسفار تعمل
+
+450
+00:37:32,630 --> 00:37:38,360
+Reabsorption للفوسفارأما الـ Parathyroid hormone
+
+451
+00:37:38,360 --> 00:37:42,560
+بشتغل مش على الأمعاء لكن بشتغل على ال kidney،
+
+452
+00:37:42,560 --> 00:37:46,840
+الكله نفسها lowers blood concentrations by
+
+453
+00:37:46,840 --> 00:37:51,120
+increasing renal excretion يخف ال Parathyroid
+
+454
+00:37:51,120 --> 00:37:56,100
+hormone يخفض مستوى الفوسفور من خلال أنه بيحفظ
+
+455
+00:37:56,100 --> 00:38:01,440
+الكله تعمل إخراج للفوسفور خارج الجسم وبالتالي هيقل
+
+456
+00:38:01,440 --> 00:38:06,720
+مستوى الفوسفور في الدمprinciple of the method زي
+
+457
+00:38:06,720 --> 00:38:11,460
+طريقة الكالسيوم انه طريقة colorimetric ان الفوسفار
+
+458
+00:38:11,460 --> 00:38:15,440
+اللي فيه بلازمة الدم برتبط مع مادة موجودة في ال
+
+459
+00:38:15,440 --> 00:38:19,760
+reagent وحصلت التفاعل اعطاء complex ملون ال
+
+460
+00:38:19,760 --> 00:38:23,040
+complex هنا بيكون لونه أزرق اللون اللي بنتج عن
+
+461
+00:38:23,040 --> 00:38:28,160
+التفاعل أزرق تمام؟الـ Organic Phosphorus، الفسفور
+
+462
+00:38:28,160 --> 00:38:34,620
+الموجود في الدم Reacts with molybdic acid forming
+
+463
+00:38:34,620 --> 00:38:40,180
+a phosphomolybdic complex الموليبدك أسد هذا حمض
+
+464
+00:38:40,180 --> 00:38:43,530
+موجود في الـ Reagentبتفاعل مع الـ Inorganic
+
+465
+00:38:43,530 --> 00:38:47,270
+Phosphorus اللي موجود في عينة المريض تعطيني
+
+466
+00:38:47,270 --> 00:38:51,830
+Complex M1 it is subsequent reduction in alkaline
+
+467
+00:38:51,830 --> 00:38:56,870
+medium originate a blue color فحصلت التفاعل اللون
+
+468
+00:38:56,870 --> 00:39:01,890
+الأزرقوالـ pH بتكون alkaline تبع الـ reagent الـ
+
+469
+00:39:01,890 --> 00:39:05,130
+intensity of the color formed is proportional to
+
+470
+00:39:05,130 --> 00:39:07,730
+the inorganic phosphorus concentration in the
+
+471
+00:39:07,730 --> 00:39:11,070
+sample شدت اللوم تتناسب تناسب ترضي مع تركيز
+
+472
+00:39:11,070 --> 00:39:16,260
+الفسوفوري الموجود في البلازمة تبع الدمالـ
+
+473
+00:39:16,260 --> 00:39:22,000
+Reference Range للفوسفورس عند الـ Adult من 2.5 ل 5
+
+474
+00:39:22,000 --> 00:39:26,680
+milligram per deciliter برضه صحوا الوحدة مش بالـ
+
+475
+00:39:26,680 --> 00:39:31,560
+micro لـ Children من 4 إلى 7 برضه بتلاحظوا الـ
+
+476
+00:39:31,560 --> 00:39:34,580
+Total Calcium و الفوسفورس أعلى عند الـ Children
+
+477
+00:39:34,580 --> 00:39:38,900
+لأن عضمهم لسه في مرحلة بناء وبالتالي الـ Bone
+
+478
+00:39:38,900 --> 00:39:43,320
+Formation تكوين العظام بتطلب وجود كالسيوم و
+
+479
+00:39:43,320 --> 00:39:48,720
+فوسفورس تمام؟هي لو بدنا التركيز بالـ Micromoleper
+
+480
+00:39:48,720 --> 00:39:54,680
+liter فالوحدة بالmilligram per deciliter سريع
+
+481
+00:39:54,680 --> 00:39:58,880
+الوحدة الأخرى millimol per liter بدنا نحول من
+
+482
+00:39:58,880 --> 00:40:02,760
+milligram per deciliter لmillimol per liter فغيروا
+
+483
+00:40:02,760 --> 00:40:07,720
+عندكم مش micromol per liter millimol وmilligram
+
+484
+00:40:07,720 --> 00:40:11,040
+تمام؟ وفي ال total calcium نفس الوحدات milligram
+
+485
+00:40:11,040 --> 00:40:18,280
+per deciliter وmillimol per literALB الـ Alkaline
+
+486
+00:40:18,280 --> 00:40:22,340
+Phosphatase يمكن حكينا عنه كثير كثير في حالات
+
+487
+00:40:22,340 --> 00:40:27,840
+تشييك على وضع الكبد على ال liver صح ولا لا؟
+
+488
+00:40:27,840 --> 00:40:31,020
+Alkaline Phosphatase is an enzyme present in
+
+489
+00:40:31,020 --> 00:40:34,720
+almost all parts of the organism being
+
+490
+00:40:34,720 --> 00:40:38,310
+particularly high in pointLiver, Placenta,
+
+491
+00:40:38,670 --> 00:40:42,810
+Intestine, Kidney تفاجنا إن الـ ALB عبارة عن
+
+492
+00:40:42,810 --> 00:40:48,210
+إنزاين تقريبا موجود في كل التشوة تبع الجسم يعني كل
+
+493
+00:40:48,210 --> 00:40:52,630
+الأعضاء اللي في الجسم فيها ALB فيها الـ Alkaline
+
+494
+00:40:52,630 --> 00:40:58,490
+Phosphatase ولكن موجود بتركيز أعلى في خمس مناطق
+
+495
+00:40:58,490 --> 00:41:02,790
+بتركز في الـ Bone وفي الـ Liver وفي الـ Placenta و
+
+496
+00:41:02,790 --> 00:41:08,070
+الـ Intestine و الـ Kidney تمام؟Poth increases and
+
+497
+00:41:08,070 --> 00:41:11,430
+decreases of plasma ALP are of importance
+
+498
+00:41:11,430 --> 00:41:16,170
+clinically بيحكيلي انخفاض أو ارتفاع مستوى ال ALP
+
+499
+00:41:16,170 --> 00:41:22,650
+مهم جدا في التشخيص Causes of increased plasma ALP
+
+500
+00:41:22,650 --> 00:41:27,050
+إيش الشغلات اللي بترفع من مستوى ال ALP في الدم
+
+501
+00:41:27,050 --> 00:41:31,170
+يعني بتزود تركيز هذا ال enzyme في الدمالـ Budget
+
+502
+00:41:31,170 --> 00:41:34,630
+Disease of Bone هتاخدوه مع الدكتور مازن Budget
+
+503
+00:41:34,630 --> 00:41:40,750
+Disease مرض وراسي بيصيب البون بتبدأ يعني في هذا
+
+504
+00:41:40,750 --> 00:41:45,310
+المرض بيصير الـ ALB يطلع من البون إلى الدم
+
+505
+00:41:45,310 --> 00:41:48,890
+وبالتالي بيزيد تركيزه في الدم حالات الـ
+
+506
+00:41:48,890 --> 00:41:54,690
+Obstructive Liver Disease تكون يعني حصاوي في الـ
+
+507
+00:41:54,690 --> 00:42:00,160
+Biliary Duct في القناع السفراويةوبالتالي الخلايا
+
+508
+00:42:00,160 --> 00:42:04,540
+المكوّنة للقضايا الصفروية بتبدأ تفرز الـ ALB تفجنا
+
+509
+00:42:04,540 --> 00:42:10,240
+أخدنا هذا الكلام حالات الـ Hepatitis التهاب خلايا
+
+510
+00:42:10,240 --> 00:42:16,800
+الكبد حالات الـ Hepatotoxicity caused by drug يعني
+
+511
+00:42:16,800 --> 00:42:23,540
+حدوث مشكلة في خلايا الكبد بسبب تناول الـ Drug معين
+
+512
+00:42:23,540 --> 00:42:29,330
+أدى إلى الـ toxicity لهذه الخلايابرضه هيرفع من
+
+513
+00:42:29,330 --> 00:42:33,110
+مستوى ال ALP حالات الـ Osteomalacia تشبه الـ
+
+514
+00:42:33,110 --> 00:42:36,970
+Osteoporesis في الفرق بينهم بس تجاوزا بنحكي نفس
+
+515
+00:42:36,970 --> 00:42:41,170
+الأشياء أن فيها شاشة في العظم وبالتالي ال ALP مركز
+
+516
+00:42:41,170 --> 00:42:46,910
+الحضن العظم فهيصير يطلع من العظم إلى الدمCauses of
+
+517
+00:42:46,910 --> 00:42:50,990
+decreased plasma ALP مستوى الـ ALP بنخفض في الدم
+
+518
+00:42:50,990 --> 00:42:55,770
+في حالات الـ Creatinism التقزم أو القزمة بيحكوا
+
+519
+00:42:55,770 --> 00:43:00,230
+عنها و Vitamin C deficiency انخفاض في Vitamin C
+
+520
+00:43:00,230 --> 00:43:05,640
+بيؤدي إلى انخفاض في مستوى الانزايم الـ ALPالـ
+
+521
+00:43:05,640 --> 00:43:10,220
+Principle of the Method ALB Enzyme بسرعة بنروح
+
+522
+00:43:10,220 --> 00:43:14,820
+تفكيرنا إلى إن الشغل هيكون Kinetic ناخد أكتر من
+
+523
+00:43:14,820 --> 00:43:20,520
+Absorbance هتتكون عندي مُركّب إحنا بدنا نقيث معدل
+
+524
+00:43:20,520 --> 00:43:25,320
+تكوين هذا المُركّب مثلا عند one minute عند two
+
+525
+00:43:25,320 --> 00:43:29,080
+minute عند three minute وهذا كله هيعبّر عن ال
+
+526
+00:43:29,080 --> 00:43:34,180
+activity تبع ال enzymeنقرأ الـ «الكالاين
+
+527
+00:43:34,180 --> 00:43:37,600
+فوسفاتيزل» الـ ALB «الكالاين فوسفاتيزل» الـ ALB
+
+528
+00:43:37,600 --> 00:43:37,960
+«الكالاين فوسفاتيزل» الـ ALB «الكالاين فوسفاتيزل»
+
+529
+00:43:37,960 --> 00:43:39,800
+الـ ALB «الكالاين فوسفاتيزل» الـ ALB «الكالاين
+
+530
+00:43:39,800 --> 00:43:42,060
+فوسفاتيزل» الـ ALB «الكالاين فوسفاتيزل» الـ ALB
+
+531
+00:43:42,060 --> 00:43:46,520
+«الكالاين فوسفاتيزل» الـ ALB «الكالاين فوسفاتيزل»
+
+532
+00:43:46,520 --> 00:43:48,620
+الـ ALB «الكالاين فوسفاتيزل» الـ ALB «الكالاين
+
+533
+00:43:48,620 --> 00:43:58,020
+فوسفاتيزل» الـ ALB «الكالاين فوسفاتيزل»
+
+534
+00:43:58,020 --> 00:44:01,400
+الـ ALB «الالـ Reagent اللي جاي من الشركة بيكون
+
+535
+00:44:01,400 --> 00:44:06,240
+فيه substrate اسمها بارا نيترو فينول فوسفات وبيكون
+
+536
+00:44:06,240 --> 00:44:10,960
+أيضا فيه مغنيسيوم كـ Co-factor بيساعد على شغل
+
+537
+00:44:10,960 --> 00:44:15,420
+إنزايم الـ ALB تمام؟ وميّه هذه مكونات الـ Reagent
+
+538
+00:44:15,420 --> 00:44:19,120
+هلجيت لما بنخلط الـ Reagent على العينة الإنزايم
+
+539
+00:44:19,120 --> 00:44:23,320
+هيكسر ال substrate ويعطيني البارا نيترو فينول و
+
+540
+00:44:23,320 --> 00:44:28,190
+فوسفات؟هل جيت انا تفاجنا انه قاينتك يعني انا مابدي
+
+541
+00:44:28,190 --> 00:44:32,110
+اقيس شدة اللون انا بعرف البارا نيتروفينول هذه مادة
+
+542
+00:44:32,110 --> 00:44:37,730
+ملونة انا مابدي اجيث لونها عند point معينة عند
+
+543
+00:44:37,730 --> 00:44:43,910
+نقطة معينة لأ انا بدي اقيس معدل تكوين البارا
+
+544
+00:44:43,910 --> 00:44:49,390
+نيتروفينول عند 1 minute و 2 minute و 3 minute و 4
+
+545
+00:44:49,390 --> 00:44:55,000
+minute وهذا التغير في معدل التكوينهو اللي هيعبّر
+
+546
+00:44:55,000 --> 00:45:00,340
+عن الـ activity تبعت الإنزين نفس شغل الإنزيمات بس
+
+547
+00:45:00,340 --> 00:45:03,640
+الفرق إنه في الإنزيمات السابقة مين اللي كان يتكون
+
+548
+00:45:03,640 --> 00:45:07,240
+الند، الند أتش هذا المُركّب بس اليوم عندي الـ
+
+549
+00:45:07,240 --> 00:45:11,320
+Paranitrophenol يعني هنا مش هيكون القراعة 340
+
+550
+00:45:11,320 --> 00:45:16,230
+انتبهوا لأن ما اتكون الند أتش اتكون مادة أخرىThe
+
+551
+00:45:16,230 --> 00:45:21,070
+Rate of Paranitrophenol Formation معدل تكوين الـ
+
+552
+00:45:21,070 --> 00:45:27,130
+Paranitrophenol بدنا نقيصه على الـ Spectrum وهو
+
+553
+00:45:27,130 --> 00:45:32,430
+بتناسب تناسب ترضي مع تركيز الـ ALB اللي موجود في
+
+554
+00:45:32,430 --> 00:45:37,310
+الـ Sampleالـ procedure يا جماعة نفس الـ procedure
+
+555
+00:45:37,310 --> 00:45:42,190
+بالظبط تبعت من؟ تبعت الـ AST والـ ALT انشرحت في
+
+556
+00:45:42,190 --> 00:45:48,010
+المعمل أول إشي إيش بنروح بنجيب؟ بنروح نجيب بلاستيك
+
+557
+00:45:48,010 --> 00:45:53,710
+تيوب و بنحطها في الـ water bath تمام؟ باخد الـ kit
+
+558
+00:45:53,710 --> 00:45:57,750
+تبع شغل ال ALP في two reagents reagent A و reagent
+
+559
+00:45:57,750 --> 00:46:01,850
+B تاخدي 800 ميكرو ليتر من ال reagent A و بتحطيها
+
+560
+00:46:01,850 --> 00:46:06,490
+في ال tubeبعدين بتجيبى 20 مايكرون من السيرام و
+
+561
+00:46:06,490 --> 00:46:11,770
+بتحطيها فوق ال 800 و بتعملي mix منيح طبعا شغلي ع
+
+562
+00:46:11,770 --> 00:46:16,830
+37 يعني أنا ده كله عملته في ال water bath و بقى
+
+563
+00:46:16,830 --> 00:46:22,910
+خليهم مدة 5 minuteبعد خمسة minute بروح أجيب
+
+564
+00:46:22,910 --> 00:46:28,210
+reagent P باخد منه 200 مايكرون و بحطهم فوق ال mix
+
+565
+00:46:28,210 --> 00:46:33,790
+اللي أنا أصلا حدرته أول ما حطت ال 200 مايكرون من
+
+566
+00:46:33,790 --> 00:46:39,810
+reagent P start stopwatch بتشغل الساعة بسرعة و
+
+567
+00:46:39,810 --> 00:46:44,650
+بتروحي تاخدي هذا ال mix اللي موجودفي الـ tube و
+
+568
+00:46:44,650 --> 00:46:48,870
+بنديره بالـ cuvette و بناخد الـ cuvette على الجهاز
+
+569
+00:46:48,870 --> 00:46:53,850
+و بنحطها و بنبدأ نحسب ناخد absorbance عند one
+
+570
+00:46:53,850 --> 00:46:57,570
+minute عند two minute عند three minute عند four
+
+571
+00:46:57,570 --> 00:47:02,570
+minute يعني بناخد أربع absorbance الجهاز بدي يكون
+
+572
+00:47:02,570 --> 00:47:08,050
+مضبوط على 405 nanometer بنصفر على distilled water
+
+573
+00:47:08,050 --> 00:47:13,370
+تمام؟جبل ما انا اصلا احط العينة تبعتي جوات الـ
+
+574
+00:47:13,370 --> 00:47:17,590
+Spectrum و بدي اكون مسافرة على ميه و بناخد 4
+
+575
+00:47:17,590 --> 00:47:22,680
+absorbentsوالحص با زي ما انتوا عارفين absorbance
+
+576
+00:47:22,680 --> 00:47:26,420
+الأول من التاني بطرحه والتاني من التالت والتالت من
+
+577
+00:47:26,420 --> 00:47:30,320
+الرابع بطلع عندي تلاتة absorbance باخدلهم ال
+
+578
+00:47:30,320 --> 00:47:34,840
+average بجمعهم و بجسمهم على تلاتة فال absorbance
+
+579
+00:47:34,840 --> 00:47:39,960
+اللي طلع في الآخر بروحه أنا ضرباه ال factor ال
+
+580
+00:47:39,960 --> 00:47:46,550
+factor بيجي مع ال pamphlet الليتبعت الـ kit تمام
+
+581
+00:47:46,550 --> 00:47:55,350
+ال factor تبع ال ALB 2764 نضرب ال average ال
+
+582
+00:47:55,350 --> 00:47:58,670
+absorbance اللي حصلت عليه من ال average بقضربه
+
+583
+00:47:58,670 --> 00:48:02,850
+بهذا ال factor بطلع تركيز ال enzyme بال
+
+584
+00:48:02,850 --> 00:48:06,750
+international unit per liter ال reference range
+
+585
+00:48:06,750 --> 00:48:11,330
+عند ال adultأعلى من 270 international unit per
+
+586
+00:48:11,330 --> 00:48:15,390
+liter عند الـ children أعلى من 800 international
+
+587
+00:48:15,390 --> 00:48:20,970
+unit per liter أيضا ال ALP أعلى من عند ال children
+
+588
+00:48:20,970 --> 00:48:24,450
+أعلى من ال adult لو سألناكم سؤال لأن الأطفال في
+
+589
+00:48:24,450 --> 00:48:30,760
+مرحلة نمو عظامهلجيت العظام تتكون من نوعين من
+
+590
+00:48:30,760 --> 00:48:33,760
+الخلايا مش موجودة عندكم بس اننا نفهمها Osteoplast
+
+591
+00:48:33,760 --> 00:48:37,860
+و Osteoclast Osteoplast تصل هذه الخلايا البناء
+
+592
+00:48:37,860 --> 00:48:42,300
+للعظم و Osteoclast هذه الخلايا الهدامة للعظمهلجيت
+
+593
+00:48:42,300 --> 00:48:46,600
+الـ Osteoplast هاد الخلايا جواتها في الـ ALB
+
+594
+00:48:46,600 --> 00:48:51,340
+جواتها في الـ enzyme فعند الأطفال بيحتاج .. يعني
+
+595
+00:48:51,340 --> 00:48:56,100
+بتكون النشط أكتر الـ Osteoplast النشطة الخلايا
+
+596
+00:48:56,100 --> 00:49:01,360
+البناء للعضم طول ما في بناء للعضم طول ما في ان هذه
+
+597
+00:49:01,360 --> 00:49:04,880
+الخلايا تفرز هذا الـ ALB وبالتالي بيزيد تركيزه
+
+598
+00:49:04,880 --> 00:49:09,380
+بالدم عشان هيك عند الـ Children الـ ALB بيكون أعلى
+
+599
+00:49:09,950 --> 00:49:12,870
+و بهيك خلصنا ال chapter و يعطيكم العافية
+
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/v_VgjVkzGH0.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/v_VgjVkzGH0.srt
new file mode 100644
index 0000000000000000000000000000000000000000..535d9808a2731fe0ca9387251a48417cc976d368
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/v_VgjVkzGH0.srt
@@ -0,0 +1,2046 @@
+
+1
+00:00:01,210 --> 00:00:04,850
+السلام عليكم ورحمة الله وبركاته، يعطيكم العافية
+
+2
+00:00:04,850 --> 00:00:09,150
+جميعًا إن شاء الله، اليوم محاضرتنا بعنوان Quality
+
+3
+00:00:09,150 --> 00:00:15,280
+Control. مراقبة الجودة. هنا بدنا نحكي عن الـ Quality
+
+4
+00:00:15,280 --> 00:00:21,360
+Assurance، برنامج ضمان الجودة. بدنا نتعرف أول شيء
+
+5
+00:00:21,360 --> 00:00:33,440
+على تعريف ضمان الجودة. عبارة عن برنامج
+
+6
+00:00:33,440 --> 00:00:41,130
+ضمان الجودة هو عبارة عن مجموعة من الخطوات المترابطة
+
+7
+00:00:41,130 --> 00:00:48,050
+التي يجب على الـ Lab Technician، يعني أخصائي التحليل،
+
+8
+00:00:48,050 --> 00:00:54,890
+اتباعها من أجل إعطاء أفضل خدمة للـ patient والـ
+
+9
+00:00:54,890 --> 00:01:00,330
+physician. أنا كـ lab technician، كأخصائي تحليل، كيف
+
+10
+00:01:00,330 --> 00:01:04,670
+أنا ممكن أقدم أفضل خدمة للـ patient والـ physician؟
+
+11
+00:01:04,670 --> 00:01:11,230
+أفضل خدمة أقصد فيها إعطاء result صحيحة، right؟
+
+12
+00:01:11,230 --> 00:01:17,100
+الـ result للـ patient. يعني أنا بعمل التحليل، واجبي أعطي
+
+13
+00:01:17,100 --> 00:01:22,540
+نتائج صحيحة، right result، للمريض وللـ physician، ولـ
+
+14
+00:01:22,540 --> 00:01:28,780
+للدكتور، عشان في الآخر الدكتور يعطي decision، قرار،
+
+15
+00:01:28,780 --> 00:01:33,160
+بناءً عليه لـ treatment. الـ Quality Assurance هذا برنامج
+
+16
+00:01:33,160 --> 00:01:38,000
+كبير، is a complete system، عبارة عن نظام معقد، which
+
+17
+00:01:38,000 --> 00:01:44,620
+contains Quality Control. كلنا بنسمع بـ مراقبة
+
+18
+00:01:44,620 --> 00:01:48,560
+الجودة، مراقبة الجودة، اللي هو الـ Quality Control،
+
+19
+00:01:48,560 --> 00:01:54,600
+يُعتبر جزء من برنامج ضمان الجودة، اللي هو الـ
+
+20
+00:01:54,600 --> 00:01:57,500
+Quality Assurance. الـ Quality Assurance هو
+
+21
+00:01:57,500 --> 00:02:04,330
+البرنامج الكبير اللي بيضم Control. تعريف آخر للـ
+
+22
+00:02:04,330 --> 00:02:09,230
+Quality Assurance: Right Result، إعطاء نتائج صحيحة،
+
+23
+00:02:10,090 --> 00:02:14,250
+تحليل صحيحة، at the right time. ما يكفي أن أعطي نتيجة
+
+24
+00:02:14,250 --> 00:02:19,670
+صحيحة، لازم أعطيها في الوقت المناسب، يعني أطلع نتيجة
+
+25
+00:02:19,670 --> 00:02:24,850
+التحليل بسرعة، ما يأخذ معي التحليل وقت، on the right
+
+26
+00:02:24,850 --> 00:02:29,870
+specimen. لما بدي أجي أشتغل على عينة صحيحة، مجموعة
+
+27
+00:02:29,870 --> 00:02:35,090
+بطريقة صحيحة، بـ Anticoagulant، مطلوبة، مأخوذة من الـ
+
+28
+00:02:35,090 --> 00:02:40,220
+right patient، من الـ Patient الصحيح، اللي مطلوب له
+
+29
+00:02:40,220 --> 00:02:41,120
+التحليل.
+
+30
+00:02:45,240 --> 00:02:48,360
+عرفنا الـ Quality Assurance، اللي هو الـ Complete
+
+31
+00:02:48,360 --> 00:02:54,580
+System، النظام الكامل المعقد الذي يضم عدة برامج.
+
+32
+00:02:54,580 --> 00:02:58,920
+طبعًا، الـ Quality Control، عرفنا اللي هو الـ Quality Control،
+
+33
+00:02:58,920 --> 00:03:02,860
+اللي هو جزء من الـ Quality Assurance. الـ Quality
+
+34
+00:03:02,860 --> 00:03:07,720
+Control، مراقبة الجودة، هو عبارة عن الـ process of
+
+35
+00:03:07,720 --> 00:03:10,620
+monitoring the accuracy and precision of
+
+36
+00:03:10,620 --> 00:03:14,670
+laboratory tests with control samples. هو عبارة عن
+
+37
+00:03:14,670 --> 00:03:21,510
+عملية متابعة لصحة ودقة النتائج اللي بيطلعها
+
+38
+00:03:21,510 --> 00:03:28,330
+المختبر من خلال استخدام عينة Control أثناء أداء
+
+39
+00:03:28,330 --> 00:03:32,990
+الفحوصات. هلق إذا أنا بدي أجي، جاني بشنق مريض، بدي
+
+40
+00:03:32,990 --> 00:03:38,290
+يعني أعمله فحص سكر، لازم أمشي مع عينته عينة Control.
+
+41
+00:03:39,000 --> 00:03:42,220
+لو إجاني شخص بدي أعمل له فحص الـ Total Protein، أو
+
+42
+00:03:42,220 --> 00:03:48,300
+Enzyme، أو أي test في الكيميا، لازم أمشي معها control.
+
+43
+00:03:48,300 --> 00:03:54,980
+إذن، مراقبة الجودة هي عملية متابعة لمدى صحة ودقة
+
+44
+00:03:55,350 --> 00:04:01,150
+النتائج اللي بيطلعها المختبر من خلال استخدام، يعني
+
+45
+00:04:01,150 --> 00:04:07,710
+أنا بشيك على صحة، ونتائج، على صحة ودقة النتائج اللي
+
+46
+00:04:07,710 --> 00:04:16,160
+بيطلعها المختبر من خلال إني بمشي عينة control، بمشي
+
+47
+00:04:16,160 --> 00:04:22,580
+عينة control مع شغلي، عشان أشيك على شغلي. تعريف آخر
+
+48
+00:04:22,580 --> 00:04:26,580
+للـ Quality Control: the statistical process used
+
+49
+00:04:26,580 --> 00:04:30,460
+to monitor and evaluate analytical processes that
+
+50
+00:04:30,460 --> 00:04:35,820
+produce patient results. هي عبارة عن عملية إحصائية
+
+51
+00:04:36,380 --> 00:04:41,480
+عادةً أنا بستخدم الـ Quality Control، مراقبة الجودة،
+
+52
+00:04:41,480 --> 00:04:48,320
+من أجل متابعة وتقييم، من أجل المتابعة وتقييم
+
+53
+00:04:48,320 --> 00:04:53,820
+العملية التحليلية أثناء تحليل الفحص. That produces
+
+54
+00:04:53,820 --> 00:05:00,150
+the patient results، اللي هي أثناء العملية التحليلية
+
+55
+00:05:00,150 --> 00:05:05,690
+اللي بدي أطلع منها، من خلالها، إعطاء نتائج لـ patient، نتيجة
+
+56
+00:05:05,690 --> 00:05:10,490
+التحليل. إذا بدي أفهم من التعريف إنه الـ Quality
+
+57
+00:05:10,490 --> 00:05:15,730
+Control يُطبّق أثناء أو في مرحلة الـ Analytical
+
+58
+00:05:15,730 --> 00:05:18,750
+phase. إحنا المرحلة التحليلية تُقسم لثلاث أقسام:
+
+59
+00:05:18,750 --> 00:05:23,970
+Pre-Analytical، Analytical، وPost-Analytical.
+
+60
+00:05:23,970 --> 00:05:27,050
+ما قبل التحليل، أثناء التحليل، بعد
+
+61
+00:05:27,050 --> 00:05:31,970
+التحليل. برنامج مراقبة الجودة يُطبّق في الـ
+
+62
+00:05:31,970 --> 00:05:35,690
+Analytical process، في عملية التحليل. أنا أثناء إنجاز
+
+63
+00:05:35,690 --> 00:05:41,090
+الفحص بمشي مع عينة control عشان أشيك على نتائج الـ
+
+64
+00:05:41,090 --> 00:05:46,380
+patient. but الـ Quality Assurance، البرنامج الكبير،
+
+65
+00:05:46,380 --> 00:05:52,740
+هذا البرنامج يُطبّق في الثلاث مراحل. عشان هيك
+
+66
+00:05:52,740 --> 00:05:57,020
+هو برنامج شامل كامل، يُطبّق في الـ Pre-
+
+67
+00:05:57,020 --> 00:06:00,620
+analytical، والـ Analytical، والـ Post-analytical.
+
+68
+00:06:00,620 --> 00:06:06,110
+لأن البرنامج الكبير، مجموعة خطوات مترابطة. لو أنا
+
+69
+00:06:06,110 --> 00:06:11,230
+كـ Lab Technician، اتبعت برنامج ضمان الجودة من أول
+
+70
+00:06:11,230 --> 00:06:15,490
+ما استلمت العينة لحد ما سجلت النتيجة، مش حنقع في
+
+71
+00:06:15,490 --> 00:06:19,150
+الخطأ. الـ Quality Control يُطبّق في الـ
+
+72
+00:06:19,150 --> 00:06:22,730
+Analytical Phase. أما الـ Quality Assurance بتتم
+
+73
+00:06:22,730 --> 00:06:26,270
+تطبيقه في الثلاث مراحل، في الـ Pre-Analytical،
+
+74
+00:06:26,270 --> 00:06:29,780
+Analytical، Post-Analytical. بتلاقي وزارة الصحة،
+
+75
+00:06:29,780 --> 00:06:34,300
+شركات بتحط لك بروتوكولات معينة، بتقول لك: اجمع العينة
+
+76
+00:06:34,300 --> 00:06:38,100
+أثناء التحليل، وأيضًا ما بعد التحليل لما تيجي تسجل
+
+77
+00:06:38,100 --> 00:06:42,440
+العينة وتخرجها. إذا هذا كله برنامج كامل، يعني
+
+78
+00:06:42,440 --> 00:06:47,540
+الهدف منه بتطلع نتيجة صحيحة. بدنا نحكي عن الـ
+
+79
+00:06:47,540 --> 00:06:50,640
+Quality Control Types، أنواع الـ Quality Control.
+
+80
+00:06:50,640 --> 00:06:54,260
+نوعين: اللي هو الـ Internal Quality Control، مراقبة
+
+81
+00:06:54,260 --> 00:06:57,920
+جودة داخلية، والـ External Quality Control، مراقبة
+
+82
+00:06:57,920 --> 00:07:02,020
+جودة خارجية. بالبداية، الـ Internal Quality Control،
+
+83
+00:07:02,020 --> 00:07:05,980
+شو تعريفها؟ is a procedure for utilizing the
+
+84
+00:07:05,980 --> 00:07:10,280
+results of only one laboratory for quality control
+
+85
+00:07:10,280 --> 00:07:16,820
+purposes. هو عبارة عن إجراء لاستخدام نتائج مختبر واحد
+
+86
+00:07:16,820 --> 00:07:24,440
+فقط لغرض مراقبة الجودة. بمفهوم أبسط من هيك، الـ
+
+87
+00:07:24,440 --> 00:07:28,220
+Internal Quality Control، معناه أنا كمختبر، أو
+
+88
+00:07:28,220 --> 00:07:34,420
+كمستشفى، لازم كل يوم مع فحوصاتي أمشي عينة الـ
+
+89
+00:07:34,420 --> 00:07:37,720
+control مع نتائج الـ patient. يعني إجاني مريض بدي
+
+90
+00:07:37,720 --> 00:07:41,600
+أفحص له السكر، بدي أمشي، بدي أمشي مع فحص السكر control.
+
+91
+00:07:41,600 --> 00:07:44,720
+بدي أفحص الـ total protein، بدي أمشي مع الـ total
+
+92
+00:07:44,720 --> 00:07:49,180
+protein control. هذا الـ control عادةً بيجي من الشركة،
+
+93
+00:07:49,180 --> 00:07:53,790
+إما powder أو liquid، سائل، وبيكون معاه أيضًا ورقة
+
+94
+00:07:53,790 --> 00:07:59,710
+بروشور فيها الـ Normal Range لكل فحص. السكر مثلًا
+
+95
+00:07:59,710 --> 00:08:03,830
+من 70 لـ 110. Total Protein من 6 لـ 8 gram per
+
+96
+00:08:03,830 --> 00:08:08,250
+deciliter. بيكون مكتوب فيه الـ Range لجميع الفحوصات.
+
+97
+00:08:08,250 --> 00:08:12,630
+أنا عليّ كل يوم أمشي مع عينات الـ patient، عينات الـ
+
+98
+00:08:12,630 --> 00:08:16,230
+control. هذا بسمّيه Internal Quality Control، بيكون
+
+99
+00:08:16,230 --> 00:08:20,910
+على نطاق one laboratory، على نطاق المختبر الواحد.
+
+100
+00:08:20,910 --> 00:08:25,810
+But الـ External Quality Control، مراقبة الجودة
+
+101
+00:08:25,810 --> 00:08:30,150
+الخارجية، هو إجراء، إن عرفنا بالإنجليزي is a
+
+102
+00:08:30,150 --> 00:08:32,950
+procedure for utilizing for quality control
+
+103
+00:08:32,950 --> 00:08:36,950
+purposes the results of several laboratories which
+
+104
+00:08:36,950 --> 00:08:41,510
+analyze the same specimens. Several laboratories
+
+105
+00:08:41,510 --> 00:08:48,680
+إيش يعني؟ هو عبارة عن إجراء لاستخدام نتائج أكثر من
+
+106
+00:08:48,680 --> 00:08:56,220
+مختبر فقط لغرض مراقبة الجودة. إيش يعني الفرق إنه
+
+107
+00:08:56,220 --> 00:09:02,310
+فوق في الـ Internal، على مستوى نطاق مختبر واحد. الـ
+
+108
+00:09:02,310 --> 00:09:06,890
+External Quality Control، مجموعة من المختبرات، يعني
+
+109
+00:09:06,890 --> 00:09:10,730
+several laboratories، بيدخلوا يصير نظام منافسة، مثلًا
+
+110
+00:09:10,730 --> 00:09:15,450
+أكثر من مستشفى، بتيجي وزارة الصحة أو شركات صحية
+
+111
+00:09:15,450 --> 00:09:21,630
+بتجيب عينات Control، تمام؟ بتوزّعها على المستشفيات.
+
+112
+00:09:21,630 --> 00:09:27,220
+هذه عينات الـ Control، بتتعامل معها المستشفى كأنها
+
+113
+00:09:27,220 --> 00:09:32,800
+عينة unknown، كأنها عينة مجهولة، مش معروفة. ومثلًا
+
+114
+00:09:32,800 --> 00:09:37,980
+وزارة الصحة بتطلب من جميع المستشفيات يأخذوا هذه
+
+115
+00:09:37,980 --> 00:09:42,960
+العينة ويحلّلوها، ويعملوا لها تحليل لمستوى السكر.
+
+116
+00:09:42,960 --> 00:09:48,040
+بتحلّل المستشفيات، بتستخدم هذه العينة وبتطلع نتيجة
+
+117
+00:09:48,040 --> 00:09:53,930
+السكر وبتطبع النتيجة وبتسلّمها لوزارة الصحة. وزارة
+
+118
+00:09:53,930 --> 00:10:00,970
+الصحة بدها تشوف هل هذه المستشفى بتطلع نتائج سليمة
+
+119
+00:10:00,970 --> 00:10:04,790
+ولا لأ؟ حتطلع فيه مستشفيات حتطلع مستوى السكر صح،
+
+120
+00:10:04,790 --> 00:10:08,290
+فيه مستشفيات لأ، ممكن يكون عندها خلل في الجهاز، في
+
+121
+00:10:08,290 --> 00:10:12,970
+الـ reagent. هنا مين بيعرف الـ normal range للسكر فقط؟
+
+122
+00:10:12,970 --> 00:10:18,720
+وزارة الصحة. المستشفى ما بتكون عندها أي ورقة بالـ
+
+123
+00:10:18,720 --> 00:10:22,300
+Normal Range تبع الـ Control اللي جايبها وزارة
+
+124
+00:10:22,300 --> 00:10:26,820
+الصحة. إذًا، الـ External Quality Control ما هو إلا
+
+125
+00:10:26,820 --> 00:10:35,080
+نظام منافسة بين المستشفيات، ومراقبة للمستشفيات من
+
+126
+00:10:35,080 --> 00:10:41,460
+قبل وزارة الصحة وشركات الصحية. عشان لو المستشفى
+
+127
+00:10:41,460 --> 00:10:46,040
+طلعت نتيجة صحيحة، أو مختبر طلع نتيجة صحيحة للعينة
+
+128
+00:10:46,040 --> 00:10:50,680
+المجهولة، إذا هذا مختبر يعني معتمد. بتصير وزارة
+
+129
+00:10:50,680 --> 00:10:54,640
+الصحة تعطيه accreditation، اعتماد. ودايمًا بنشوف
+
+130
+00:10:54,640 --> 00:10:57,960
+فيه إن مختبر بيطلع نتائج سليمة وصحيحة. ليش؟ لأن
+
+131
+00:10:57,960 --> 00:11:02,740
+وزارة الصحة عملت نظام اختبار للمستشفيات، اختبرتهم
+
+132
+00:11:02,740 --> 00:11:08,460
+بإعطائهم عينة control، مش معروف الـ normal range
+
+133
+00:11:08,460 --> 00:11:13,220
+للفحص اللي طلبته الصحة. هذا الـ External، الخارجية،
+
+134
+00:11:13,220 --> 00:11:19,220
+على مستوى أكثر من مختبر وأكثر من مستشفى. When errors
+
+135
+00:11:19,220 --> 00:11:23,040
+occur، متى تحدث الأخطاء؟ Errors occur when there is
+
+136
+00:11:23,040 --> 00:11:26,320
+a loss of accuracy and precision. تحدث الأخطاء
+
+137
+00:11:26,320 --> 00:11:33,020
+عندما نفقد الـ accuracy والـ precision، صحة ودقة
+
+138
+00:11:33,020 --> 00:11:38,000
+النتائج. لو تم فقدها، معناه أكيد في عندي خطأ، معناه
+
+139
+00:11:38,000 --> 00:11:44,280
+حدث خطأ. A primary goal of a Quality Assurance، الهدف
+
+140
+00:11:44,280 --> 00:11:50,500
+الأساسي والأول لبرنامج ضمان الجودة، is to reduce
+
+141
+00:11:50,500 --> 00:11:56,420
+and detect errors، تقليل وكشف الأخطاء. يكشف عن الخطأ
+
+142
+00:11:56,420 --> 00:12:02,440
+ويقلّل من هذا الخطأ. Or to obtain the best
+
+143
+00:12:02,440 --> 00:12:05,920
+possible accuracy and precision. أيضًا من هدف هذا
+
+144
+00:12:05,920 --> 00:12:14,020
+البرنامج، تقديم أفضل صحة ودقة للنتيجة. الـ Source of
+
+145
+00:12:14,020 --> 00:12:18,560
+Error، مصادر الأخطاء. All analytical results are
+
+146
+00:12:18,560 --> 00:12:22,720
+subject to errors arising from a variety of causes
+
+147
+00:12:22,720 --> 00:12:26,140
+but it’s kept to a minimum. كل النتائج
+
+148
+00:12:26,140 --> 00:12:32,700
+التحليلية، كل الفحوصات في المختبر، معرضة أن يصير
+
+149
+00:12:32,700 --> 00:12:39,280
+فيها أخطاء، وهذه الأخطاء من أسباب مختلفة، لكن أنا
+
+150
+00:12:39,280 --> 00:12:43,140
+كـ lab technician، بدي أحاول أُقلّل من حدوث هذه
+
+151
+00:12:43,140 --> 00:12:47,840
+الأخطاء. الـ errors can occur at various stages in
+
+152
+00:12:47,840 --> 00:12:54,670
+the process. الأخطاء تحدث في مراحل مختلفة من عملية
+
+153
+00:12:54,670 --> 00:12:58,790
+التحليل. الأخطاء تحدث في الـ Pre-analytical phase،
+
+154
+00:12:58,790 --> 00:13:02,110
+وفي الـ Analytical phase، والـ Post-Analytical
+
+155
+00:13:02,110 --> 00:13:05,770
+phase. في الـ Pre-analytical phase، يعني هذه أخطاء
+
+156
+00:13:05,770 --> 00:13:11,490
+تحدث outside the lab، خارج المختبر، أثناء جمع العينة.
+
+157
+00:13:11,490 --> 00:13:15,990
+الـ Analytical phase، أخطاء تحدث within the lab، يعني
+
+158
+00:13:15,990 --> 00:13:20,480
+أثناء التحليل، أثناء عملية الفحص. أما الـ Post-
+
+159
+00:13:20,480 --> 00:13:25,340
+Analytical، هذه عبارة عن Error بتحدث بعد عملية
+
+160
+00:13:25,340 --> 00:13:30,100
+التحليل. إيش الـ Post-Analytical  بتحدث؟ The
+
+161
+00:13:30,100 --> 00:13:33,700
+correct result is generated، أنا مثلًا بكون مطلّعة
+
+162
+00:13:33,700 --> 00:13:38,640
+نتائج صحيحة، و100%، but is incorrectly recorded in
+
+163
+00:13:38,640 --> 00:13:43,540
+the patient’s record، لكن المشكلة في عملية التسجيل.
+
+164
+00:13:43,540 --> 00:13:47,420
+إحنا عارفين معظم مشاكل الـ Post-analytical، ما بعد
+
+165
+00:13:47,420 --> 00:13:51,140
+التحليل، عملية تسجيل النتيجة. أنا بكون مطلّعة النتيجة
+
+166
+00:13:51,140 --> 00:13:56,620
+صح، بس نسجلها في السجل، أو ببعثها للدكتور، يكتبها خطأ،
+
+167
+00:13:56,620 --> 00:14:02,710
+يدخلها على الـ lab خطأ، تمام؟ الـ True Analytical
+
+168
+00:14:02,710 --> 00:14:06,890
+Errors are those which occur during the actual
+
+169
+00:14:06,890 --> 00:14:09,850
+performance of the analysis which can be
+
+170
+00:14:09,850 --> 00:14:14,290
+classified into systematic error and random error.
+
+171
+00:14:14,290 --> 00:14:19,550
+بيحكي لي الأخطاء التحليلية الحقيقية هي اللي بتحدث
+
+172
+00:14:19,550 --> 00:14:27,030
+أثناء العملية التحليلية، أثناء الشغل الحقيقي، الـ
+
+173
+00:14:27,030 --> 00:14:31,350
+Actual Performance، الأداء الحقيقي للتحليل، يعني
+
+174
+00:14:31,350 --> 00:14:36,590
+أثناء ما أنت بتحلل العينة. هذه أخطاء حقيقية، جوهرية،
+
+175
+00:14:36,590 --> 00:14:41,350
+أثناء التحليل، اللي بتحدث، وتُقسم الأخطاء لقسمين:
+
+176
+00:14:41,350 --> 00:14:46,610
+Systematic Error، خطأ منهجي، و Random Error، خطأ
+
+177
+00:14:46
+
+223
+00:18:25,820 --> 00:18:30,520
+Proportional Error الخطأ المتناسب  Error in a test
+
+224
+00:18:30,520 --> 00:18:35,500
+system in which the amount of error increases the
+
+225
+00:18:35,500 --> 00:18:39,620
+concentration of the substance being measured هو
+
+226
+00:18:39,620 --> 00:18:45,350
+عبارة عن الخطأ اللي بيصير أثناء عملية التحليل حجم
+
+227
+00:18:45,350 --> 00:18:53,030
+هذا الخطأ يزداد بزيادة تركيز الـ analyte جوات
+
+228
+00:18:53,030 --> 00:18:57,430
+العينة،  الفرق بينه وبين الـ Constant Error إن
+
+229
+00:18:57,430 --> 00:19:01,830
+الـ Proportional Error هذا الخطأ المتناسب ما بيظل
+
+230
+00:19:01,830 --> 00:19:07,870
+ثابت، بيزداد حجم هذا الخطأ كل ما زاد تركيز مثلا الـ
+
+231
+00:19:07,870 --> 00:19:11,350
+analyte اللي هو مثلا السكر اللي موجود في العينة
+
+232
+00:19:11,350 --> 00:19:17,110
+مثلا لو إيجتني عينة سكرها 70% لها نسبة خطأ معينة
+
+233
+00:19:17,110 --> 00:19:23,250
+طيب لو زودت تركيز السكر خليته 200% نسبة الخطأ هتزيد
+
+234
+00:19:23,250 --> 00:19:29,730
+إذا نسبة الخطأ تزداد بزيادة تركيز الانالايت اللي
+
+235
+00:19:29,730 --> 00:19:37,140
+أنا بدي أجيسه داخل العينة، لو جينا برجع بعيد نفس
+
+236
+00:19:37,140 --> 00:19:41,000
+الكلام، بحكي عن الـTypes of Systematic Error عن
+
+237
+00:19:41,000 --> 00:19:44,760
+أنواع الخطأ المنهجي، حكينا Proportional Error خطأ
+
+238
+00:19:44,760 --> 00:19:49,000
+متناسب و Constant Error وخطأ ثابت بالنسبة
+
+239
+00:19:49,000 --> 00:19:53,320
+لـ Proportional Error، في كمان تعريف له: The magnitude
+
+240
+00:19:53,320 --> 00:19:57,520
+of the error grows with the concentration of the
+
+241
+00:19:57,520 --> 00:20:03,100
+material being measured، هو الخطأ اللي بيزداد، تزداد
+
+242
+00:20:03,100 --> 00:20:08,860
+نسبته بزيادة تركيز الانالايت اللي موجود في العينة
+
+243
+00:20:08,860 --> 00:20:13,160
+زي ما احنا شايفين بالرسم، الأولى بتعبر عن الـ
+
+244
+00:20:13,160 --> 00:20:19,350
+proportional error، في عندي علاقة طردية ما بين نسبة
+
+245
+00:20:19,350 --> 00:20:24,010
+الخطأ اللي بتصير وما بين تركيز الانالايت اللي أنا
+
+246
+00:20:24,010 --> 00:20:29,250
+بجيسه جواه العينة، كل ما مثلا كان تركيز السكر أكثر
+
+247
+00:20:29,250 --> 00:20:34,410
+كل ما زاد حجم الخطأ، أما لما أحكيلك constant error
+
+248
+00:20:34,410 --> 00:20:39,390
+العكس يعني هذا الخطأ الثابت، the magnitude of the
+
+249
+00:20:39,390 --> 00:20:43,450
+error remains the same through the range or
+
+250
+00:20:43,450 --> 00:20:47,520
+concentration of the material being measured، هو
+
+251
+00:20:47,520 --> 00:20:54,140
+الخطأ الذي يبقى ثابت مهما زاد تركيز الـ analyte
+
+252
+00:20:54,140 --> 00:20:58,620
+جواه العينة، يعني مهما اختلف مستوى السكر جواه
+
+253
+00:20:58,620 --> 00:21:04,560
+العينة بيظل هذا الخطأ الثابت له نسبة معينة مثلا
+
+254
+00:21:04,560 --> 00:21:12,150
+بحكيلك نسبة الخطأ لفحص السكر مثلا 10%، خلاص بتظلها
+
+255
+00:21:12,150 --> 00:21:16,990
+الـ 10% هذه ثابتة، هذا بيسموه constant error، مهما
+
+256
+00:21:16,990 --> 00:21:21,830
+كان تركيز السكر في العينة، والرسمة الثانية اللي هي
+
+257
+00:21:21,830 --> 00:21:25,350
+بتمثل الـ constant error
+
+258
+00:21:27,760 --> 00:21:31,520
+أما بالنسبة لـ Random Errors الأخطاء العشوائية
+
+259
+00:21:31,520 --> 00:21:35,420
+أشهر تعريفاتها: Errors are mistakes that occur without
+
+260
+00:21:35,420 --> 00:21:39,520
+prediction or regularity، هي الأخطاء اللي بتصير من
+
+261
+00:21:39,520 --> 00:21:46,200
+غير أي تنبؤ أو انتظام، يعني lab technician أخصائي
+
+262
+00:21:46,200 --> 00:21:51,240
+التحليل ما بتنبأ بالخطأ، إنما يحدث الخطأ فجأة بشكل
+
+263
+00:21:51,240 --> 00:21:56,910
+عشوائي، manifest themselves by variations in the
+
+264
+00:21:56,910 --> 00:22:01,410
+results of repeated analyses of the same sample،
+
+265
+00:22:01,410 --> 00:22:05,210
+either positive or negative errors are usually
+
+266
+00:22:05,210 --> 00:22:08,770
+distributed، أيضًا هنا بيحكيلي بقدر أكشف الـ Random
+
+267
+00:22:08,770 --> 00:22:12,870
+error من خلال التحليل المستمر، بجيب عينة control
+
+268
+00:22:12,870 --> 00:22:16,870
+وبفحصلها مستوى السكر بعد ساعة كمان وبعد ساعتين
+
+269
+00:22:16,870 --> 00:22:21,510
+مثلا اشتغلت الفحص عشر مرات، يفترض العشر نتائج تكون
+
+270
+00:22:21,510 --> 00:22:26,960
+متقاربة، لكن لو طلعت 9 نتائج متقاربة ونتيجة واحدة هي
+
+271
+00:22:26,960 --> 00:22:30,720
+اللي فيها المشكلة، فقط نتيجة واحدة بحكي أكيد هذا
+
+272
+00:22:30,720 --> 00:22:36,220
+خطأ random عشوائي، فجأة حدث عندي خلل أدى إلى حدوث
+
+273
+00:22:36,220 --> 00:22:42,120
+تغير في هذه النتيجة، إذا لو حدث عندي مشكلة في نتيجة
+
+274
+00:22:42,120 --> 00:22:47,640
+واحدة فقط، أنا بحكي هنا في random error، لكن نتيجتين
+
+275
+00:22:47,640 --> 00:22:53,340
+حدث فيهم خلل أو أكثر هذا systematic error، these
+
+276
+00:22:53,340 --> 00:22:57,140
+variations may be caused by several variable
+
+277
+00:22:57,140 --> 00:23:01,220
+factors which include، هنا في هذه العبارة بيحكي ليه
+
+278
+00:23:01,220 --> 00:23:06,020
+بكل بساطة أسباب الـ random error، ليش بيصير الخطأ
+
+279
+00:23:06,020 --> 00:23:12,460
+العشوائي، أسبابه: variations in apparatus، حدوث تذبذب
+
+280
+00:23:12,460 --> 00:23:16,440
+في شغل الـ apparatus اللي هي الأجهزة، يقصد فيها
+
+281
+00:23:16,440 --> 00:23:21,460
+الأجهزة في المختبر، مثلا عندنا جهاز الكيميا هذا
+
+282
+00:23:21,460 --> 00:23:25,540
+الجهاز بيعمل كل الفحوصات بدل ما نشتغلها يدويا
+
+283
+00:23:25,540 --> 00:23:29,740
+manual، بيشتغلها automated، بيشتغل السكر البروتينات
+
+284
+00:23:29,740 --> 00:23:34,820
+الأنزيمات وكل حاجة، هذا الجهاز من جوا فكرة عمله مثل
+
+285
+00:23:34,820 --> 00:23:39,760
+فكرة عمل الـ Spectrophotometer، جواته فيه لمبة، هذه
+
+286
+00:23:39,760 --> 00:23:44,000
+اللمبة بتطلع ضوء، هذا الضوء بيروح بيدرب في العينة
+
+287
+00:23:44,000 --> 00:23:49,320
+تبعنا، بيخترق العينة وبيبدأ الامتصاص والجهاز
+
+288
+00:23:49,320 --> 00:23:54,940
+بيقرأ لي absorbance، تمام؟ لكن لو فجأة حدث عندي
+
+289
+00:23:54,940 --> 00:23:59,580
+تذبذب في الجهاز، يعني تذبذب في التيار الكهربائي
+
+290
+00:23:59,580 --> 00:24:02,760
+اللي مشبوك فيه الجهاز، الجهاز مشبوك على الكهربا
+
+291
+00:24:02,760 --> 00:24:09,100
+فجأة ممكن التيار الكهربائي يضعف، لما بيضعف الشعاع
+
+292
+00:24:09,100 --> 00:24:13,050
+اللي بيطلع من اللمبة بيكون كتير ضعيف، وحتى لو ضرب
+
+293
+00:24:13,050 --> 00:24:18,050
+بيه العينة تبعتي مش هيعطيني القراءة الصحيحة
+
+294
+00:24:18,050 --> 00:24:22,470
+وبالتالي النتيجة هتكون خاطئة، إذا التيار الكهربائي
+
+295
+00:24:22,470 --> 00:24:26,910
+لما بيضعف، بيضعف للحظة و بيرجع، عشان هيك هتلاحظ
+
+296
+00:24:26,910 --> 00:24:31,690
+لو عملتي فحص السكر لعشر مرات لعينة الـ control في
+
+297
+00:24:31,690 --> 00:24:35,900
+كل المرات طلعت النتائج صحيحة ما عدا مرة، هذا random
+
+298
+00:24:35,900 --> 00:24:41,180
+error، بحكي ممكن ضعفت الكهربا على الجهاز فخلال ما
+
+299
+00:24:41,180 --> 00:24:45,580
+ضعفت أعطاني نتيجة خاطئة، تمام، أو variation في الـ
+
+300
+00:24:45,580 --> 00:24:49,940
+temperature مثلا درجات الحرارة، ظروف التفاعل لو
+
+301
+00:24:49,940 --> 00:24:54,100
+اختلفت للحظة مثلا درجة الحرارة تحت الغرفة يفترض
+
+302
+00:24:54,100 --> 00:25:01,740
+تكون 22 ل 25 درجة مئوية، هذا كله بيأثر على الفحوصات
+
+303
+00:25:01,740 --> 00:25:07,620
+اللي احنا بنشتغلها، الـ weighting اللي هو الميزان
+
+304
+00:25:07,620 --> 00:25:13,380
+اللي بنستخدمه مثلا لوزن بعض الشغلات، برضه في أجهزة
+
+305
+00:25:13,380 --> 00:25:17,740
+بتكون على الكهربا برضه، مشكلة أو تذبذب في الكهربا
+
+306
+00:25:17,740 --> 00:25:21,460
+هيعمل عندنا مشكلة ويعطينا نتائج خاطئة، الـ Random
+
+307
+00:25:21,460 --> 00:25:24,830
+error cannot be avoided، للأسف، الأخطاء العشوائية ما
+
+308
+00:25:24,830 --> 00:25:29,410
+بقدر أتجنبها، يعني أنا بحاول أقلل منها بس دايما
+
+309
+00:25:29,410 --> 00:25:33,290
+بتجيني فجأة، خلاف الـ Systematic Errors، Systematic
+
+310
+00:25:33,290 --> 00:25:37,610
+Error بقدر يعني avoided، يعني بقدر أني أتجنبها
+
+311
+00:25:37,610 --> 00:25:42,150
+these random errors can be reduced، أنا ممكن أقلل
+
+312
+00:25:42,150 --> 00:25:46,460
+من حدوث الـ Random Error by more precise method and
+
+313
+00:25:46,460 --> 00:25:51,340
+more accurate equipment، إن أختار معدات وأجهزة وطرق
+
+314
+00:25:51,340 --> 00:25:56,310
+تحليل تكون صحيحة ودقيقة، هنا بدنا نحكي عن الـ method
+
+315
+00:25:56,310 --> 00:26:00,650
+validation، التأكد من صحة الطريقة المستخدمة في
+
+316
+00:26:00,650 --> 00:26:06,770
+التحليل أو تقييم الطريقة أو تقييم الـ kit الجديد
+
+317
+00:26:06,770 --> 00:26:11,770
+اللي بدنا نشتريه من الشركة المصنعة، أنا كمختبر خاص
+
+318
+00:26:11,770 --> 00:26:17,050
+بشتغل مثلا فحص السكر، بدي كيتات للسكر، كيت السكر عبارة
+
+319
+00:26:17,050 --> 00:26:21,330
+عن شو؟ بيكون فيه الـ reagent، الـ standard الخاص
+
+320
+00:26:21,330 --> 00:26:25,940
+بالسكر، هذا من وين، مين بيصنعه؟ بتصنعه الشركة عادة
+
+321
+00:26:25,940 --> 00:26:30,160
+أنا لما أروح أجيب هذا الـ kit غلط أجيبه من الشركة
+
+322
+00:26:30,160 --> 00:26:34,600
+وبسرعة أروح أستخدمه وأعمل فيه فحوصات وأطلع نتائج
+
+323
+00:26:34,600 --> 00:26:41,260
+للناس، يجب قبل استخدام الـ kit أشيك على خمس شغلات في
+
+324
+00:26:41,260 --> 00:26:45,340
+الـ kit، بدي أشيك على الـ Accuracy الصحة وعلى
+
+325
+00:26:45,340 --> 00:26:49,000
+الـ Precision الدقة وعلى الـ Sensitivity الحساسية
+
+326
+00:26:49,000 --> 00:26:53,640
+وعلى الـ Specificity التخصصية وعلى الـ Linearity
+
+327
+00:26:53,640 --> 00:26:58,440
+الخطية، يعني خمس شغلات بتاخدها بعين الاعتبار عند
+
+328
+00:26:58,440 --> 00:27:03,620
+شراء أي كيت جديد لأي فحص، أول شيء الـ Accuracy
+
+329
+00:27:03,620 --> 00:27:08,260
+الصحة، The measure of correctness or truth of
+
+330
+00:27:08,260 --> 00:27:15,300
+laboratory test، هي عبارة عن قياس القيمة الحقيقية
+
+331
+00:27:15,300 --> 00:27:21,360
+للفحص، هذه الـ accuracy الصحة يعني .. يعني قد ايش أنت
+
+332
+00:27:21,360 --> 00:27:25,380
+.. يعني قد ايش هذا الـ kit بيعطيني، وهذا الـ reagent
+
+333
+00:27:25,380 --> 00:27:29,080
+والمواد تعطيني نتيجة صحيحة، يعني لو أنا استخدمت
+
+334
+00:27:29,080 --> 00:27:33,420
+الـ kit واستخدمت الـ reagent تبع السكر، قد ايش هذا
+
+335
+00:27:33,420 --> 00:27:38,660
+الـ reagent بيعطيني صحة في النتائج، هذا معنى الـ
+
+336
+00:27:38,660 --> 00:27:45,900
+Accuracy، هي عبارة عن قياس القيمة الحقيقية للفحص، زي
+
+337
+00:27:45,900 --> 00:27:52,700
+ما احنا شايفين، وين جاي السهم؟ جاي السهم Target، لو
+
+338
+00:27:52,700 --> 00:27:58,890
+كان الـ kit تبعنا بيجيب مستوى السكر target، معناه هذا
+
+339
+00:27:58,890 --> 00:28:02,630
+المطلوب، معناه هذا الـ kit ممتاز، هذا الـ reagent
+
+340
+00:28:02,630 --> 00:28:08,390
+100% كويس، لأنه بيجيب لي القيمة target، بضبط
+
+341
+00:28:08,390 --> 00:28:13,950
+القيمة الحقيقية، تمام، الـ Accuracy إلها تعريف آخر مش
+
+342
+00:28:13,950 --> 00:28:18,670
+موجود عندنا، هتاخدوه بالنظر مع الدكتور مازن، هو
+
+343
+00:28:18,670 --> 00:28:25,270
+عبارة عن مدى قرب القيمة المقاسة من القيمة الحقيقية،
+
+344
+00:28:25,810 --> 00:28:29,290
+القيمة المقاسة اللي أنا جستها بالـ kit، القيمة
+
+345
+00:28:29,290 --> 00:28:34,530
+الحقيقية هي القيمة اللي أصلا شركة مثلا لما بتجيبلك
+
+346
+00:28:34,530 --> 00:28:38,130
+Control، تعطيك الـ Normal Range للسكر تبعه، فالجهاز
+
+347
+00:28:38,130 --> 00:28:41,890
+لو أنا استخدمت الـ Control هذا وجست له السكر بالـ
+
+348
+00:28:41,890 --> 00:28:47,730
+kit وطلع نتيجة، النتيجة اللي أنا طلعتها دي قيمة
+
+349
+00:28:47,730 --> 00:28:52,890
+مقاسة، فمدى قرب القيمة المقاسة اللي أنا طلعتها من
+
+350
+00:28:52,890 --> 00:28:57,190
+القيمة الحقيقية اللي طلعتها الشركة، هذا بنسميه الـ
+
+351
+00:28:57,190 --> 00:29:00,170
+Accuracy، يعني لو كانت القيمة اللي أنا جيستها 70
+
+352
+00:29:00,170 --> 00:29:04,870
+وقيمة الشركة اللي طلعتها الشركة 72، معناه هذا الـ kit ممتاز لأنه بيطلع نتائج كويسة، الـ
+
+354
+00:29:09,540 --> 00:29:14,100
+Precision اللي هي مدى الإحكام، الـ Agreement
+
+355
+00:29:14,100 --> 00:29:19,120
+between replicate measurements، مدى التوافق بين
+
+356
+00:29:19,120 --> 00:29:24,360
+النتائج اللي طلعت، نتيجة الـ replication، إعادة
+
+357
+00:29:24,360 --> 00:29:29,280
+الفحص، هنا مفهوم الـ Precision، حكيت لكم إيه الـ kit
+
+358
+00:29:29,280 --> 00:29:34,490
+Control، هذا الـ Control أعمله فحص السكر أكثر من مرة
+
+359
+00:29:34,490 --> 00:29:40,710
+عشر مرات، مدى قرب النتائج من بعضها البعض هذا بنسميه
+
+360
+00:29:40,710 --> 00:29:44,990
+precision، والله هذا الـ kit more precise، أنا جبت كيت
+
+361
+00:29:44,990 --> 00:29:50,290
+جديد وجبت عينة وحللت هذه العينة بهذا الـ kit عشر
+
+362
+00:29:50,290 --> 00:29:54,250
+مرات، والنتائج مثلا عملت فحص السكر النتائج كانت
+
+363
+00:29:54,250 --> 00:29:58,930
+كلها متقاربة من بعض، تقارب النتائج من بعض هذا بنسميه
+
+364
+00:29:58,930 --> 00:30:04,100
+precision، التقارب، الإحكام أو بيسموه الـ
+
+365
+00:30:04,100 --> 00:30:06,940
+Reproducibility، معناه إنت إيش يعني
+
+366
+00:30:06,940 --> 00:30:11,080
+Reproducibility؟ لما تعمل إعادة للفحص أكثر من مرة
+
+367
+00:30:11,080 --> 00:30:16,260
+هتلاقي النتائج هي نفسها متقاربة، هي عندنا أكثر من
+
+368
+00:30:16,260 --> 00:30:20,560
+سهم، عملت الفحص أكثر من مرة يعني عندي أكثر من سهم
+
+369
+00:30:20,560 --> 00:30:24,720
+وكل الأسهم زي ما إحنا شايفين متقاربة، معناه فيه
+
+370
+00:30:24,720 --> 00:30:30,680
+precision عالي، عندنا إحكام عالي، لو إيجينا للرسمة
+
+371
+00:30:30,680 --> 00:30:33,880
+اللي أمامنا، خلينا نتطلع في الرسمتين اللي فوق
+
+372
+00:30:33,880 --> 00:30:39,060
+بالأول، الرسمة اللي على اليمين، هتلاحظ نقطة ثمرة
+
+373
+00:30:39,060 --> 00:30:42,620
+كبيرة بالنص، هذه النقطة الثمرة الكبيرة بالنص بتعبر
+
+374
+00:30:42,620 --> 00:30:49,300
+أنه أنا كانت عندي عينة وجبت كيت السكر واشتغلت هذه
+
+375
+00:30:49,300 --> 00:30:54,660
+العينة أكثر من مرة، فحص السكر، وطلع عندي مجموعة نتائج
+
+376
+00:30:54,660 --> 00:31:00,500
+هذه النتائج كلها متراكمة وكلها جانب بعض، اتكومت
+
+377
+00:31:00,500 --> 00:31:06,020
+وانحطت بالنص، معناه هذا الـ kit عنده high precision،
+
+378
+00:31:06,020 --> 00:31:10,100
+إيش يعني high precision؟ إن النتائج متقاربة كتير من
+
+379
+00:31:10,100 --> 00:31:13,560
+بعض، لو أنت عدت الفحص أكثر من مرة النتائج متقاربة
+
+380
+00:31:13,560 --> 00:31:18,900
+و high accuracy يعني عندي صحة، كل النتائج اجت بالنص
+
+381
+00:31:18,900 --> 00:31:24,630
+اجت target، تمام؟ أما الرسم اللي فوق اللي على اليسار
+
+382
+00:31:24,630 --> 00:31:29,650
+لو لاحظتي أنه عندي مجموعة نتائج متكومة تمام، نقطة
+
+383
+00:31:29,650 --> 00:31:35,030
+ثمرة متكومة، ومحطوطين تمام، بيحكي لك high precision،
+
+384
+00:31:35,030 --> 00:31:39,410
+okay، نتائج متقاربة من بعضها، البعد معناه في عندي
+
+385
+00:31:39,410 --> 00:31:45,150
+precision لكن لا accuracy، هذا الكيت مافي صح، ليش؟
+
+386
+00:31:45,150 --> 00:31:50,600
+لأنه النتائج ما اجت في الـ target، الـ target عنده
+
+387
+00:31:50,600 --> 00:31:56,120
+بالنص أو الدائرة الحمرا هذه target، لكن اجت برا، لأ
+
+388
+00:31:56,120 --> 00:32:02,180
+بتكون فقدت الصحة، تعالوا نشوف اليسار تحت، الرسمتين
+
+389
+00:32:02,180 --> 00:32:04,080
+اللي على اليسار تحت
+
+390
+00:32:08,030 --> 00:32:14,110
+الرسمتين اللي تحت، جهة اليمين، بتلاحظ فيه نتائج
+
+391
+00:32:14,110 --> 00:32:18,790
+متفرقة عن بعضها البعض، مش متكومة مع بعضها البعض،
+
+392
+00:32:18,790 --> 00:32:23,290
+النتائج متفرقة، معناه مافي precision، مافي توافق
+
+393
+00:32:23,290 --> 00:32:29,050
+بينها، مافي تقارب، لكن فيه high accuracy، في صحة، يعني
+
+394
+00:32:29,050 --> 00:32:33,5
+
+445
+00:36:34,950 --> 00:36:39,210
+الـLinearity الخطية عبارة عن is the range over
+
+446
+00:36:39,210 --> 00:36:42,990
+which the analytical system exhibits a linear هو
+
+447
+00:36:42,990 --> 00:36:48,890
+النطاق الذي يظهر فيه النظام التحليلي خطياً بمعنى
+
+448
+00:36:48,890 --> 00:36:54,770
+يعني بمعنى أبسط من هيك، وكلنا عارفينه إن الخطية و
+
+449
+00:36:54,770 --> 00:36:59,430
+الـ linearity تبعت أي Kit هو أعلى قيمة وأقل قيمة
+
+450
+00:36:59,430 --> 00:37:04,030
+يستطيع الـ Kit قياسهم، إذا أعلى قيمة وأقل قيمة
+
+451
+00:37:04,030 --> 00:37:07,490
+يستطيع الـ Kit قياسهم، هذه الـ linearity، the
+
+452
+00:37:07,490 --> 00:37:12,100
+highest concentration can be detected، تمام؟ يعني
+
+453
+00:37:12,100 --> 00:37:16,460
+مثلاً كل Kit له Linearity معينة، مثلاً السكر بكتب
+
+454
+00:37:16,460 --> 00:37:21,220
+لك في الـ pamphlet تبعه، في الورقة أن هذا الـ Kit
+
+455
+00:37:21,220 --> 00:37:27,720
+بيقدر يقيس السكر من 46 إلى 600، لو إجاني شخص سُكّره
+
+456
+00:37:27,720 --> 00:37:34,720
+أعلى من 600 أو أقل من 46، مش هيقدر هذا الـ Reagent
+
+457
+00:37:34,720 --> 00:37:39,420
+يتفاعل مع السكر اللي موجود بعينته، ومش هيعطيني أي
+
+458
+00:37:39,420 --> 00:37:43,740
+نتيجة، هذه فكرة الـ Linearity، مين بيقيسها؟ بتقيصها
+
+459
+00:37:43,740 --> 00:37:49,120
+الشركة. The measured value from a series of samples
+
+460
+00:37:49,120 --> 00:37:53,820
+solution is linearly proportional to the actual
+
+461
+00:37:53,820 --> 00:37:58,120
+concentration or content of the analyte in the
+
+462
+00:37:58,120 --> 00:38:03,660
+sample solution. هذا الكلام يعني هو شغل شركات أكثر
+
+463
+00:38:03,660 --> 00:38:09,160
+من أنه يعني احنا لازم نهتم فيه. عند الرسم اللي فوق
+
+464
+00:38:09,160 --> 00:38:17,020
+هي شكل Linear، هذا بتكون X-axis وY-axis، على الـ X
+
+465
+00:38:17,020 --> 00:38:21,860
+-axis تحت بحطوا الـ actual concentration التركيز
+
+466
+00:38:21,860 --> 00:38:26,220
+اللي من الشركة، وعلى الـ Y-axis بحطوا الـ measured
+
+467
+00:38:26,220 --> 00:38:30,820
+value، القيم اللي أنا قستها، والشركة بتمثل
+
+468
+00:38:30,820 --> 00:38:34,920
+العلاقة، وهي اللي بتحسب الخطيئة فقط. هذا اللي بدنا
+
+469
+00:38:34,920 --> 00:38:40,250
+نفهمه. بدنا نفرق بين الـ Control والـ Standard والـ
+
+470
+00:38:40,250 --> 00:38:43,870
+الـ Calibrator لأن كتير في ناس بتخلط بينهم. الـ
+
+471
+00:38:43,870 --> 00:38:48,950
+Control هو عبارة عن محلول بيجينا من الشركة إما
+
+472
+00:38:48,950 --> 00:38:54,430
+Powder أو Liquid، وعبارة عن solution، محلول يحتوي
+
+473
+00:38:54,430 --> 00:39:01,000
+على نفس مكونات عينة المريض. أصلاً الـ control من وين
+
+474
+00:39:01,000 --> 00:39:05,740
+بيعملوها؟ من ناس صحية أو من ناس مرضى، صح ولا لا؟
+
+475
+00:39:05,740 --> 00:39:10,080
+سواء بيعملوا normal control أو abnormal control،
+
+476
+00:39:10,080 --> 00:39:14,740
+إذا مكونات الـ control هي نفس مكونات الدم تبع الـ
+
+477
+00:39:14,740 --> 00:39:18,800
+patient، تبع المريض، نفس المكونات، a solution that
+
+478
+00:39:18,800 --> 00:39:24,680
+contains the same constituents، نفس المكونات، as those
+
+479
+00:39:24,680 --> 00:39:28,400
+being analyzed in the patient sample، وعادة بيجيني
+
+480
+00:39:28,400 --> 00:39:31,780
+مع الشركة، وبتيجي معاها ورقة، هذه الورقة فيها
+
+481
+00:39:31,780 --> 00:39:36,160
+الـ normal range، مثلاً السكر من 70 لـ 110 milligram
+
+482
+00:39:36,160 --> 00:39:41,920
+per deciliter، فيه range للـ analyte
+
+483
+00:39:41,920 --> 00:39:47,520
+اللي أنا بدي أقيسها. أما الـ standard عبارة عن
+
+484
+00:39:47,520 --> 00:39:51,620
+substance of constant composition and of
+
+485
+00:39:51,620 --> 00:39:55,000
+sufficient purity to be used for comparison
+
+486
+00:39:55,000 --> 00:40:01,570
+purposes. الـ Standard عبارة عن محلول يحتوي على مادة
+
+487
+00:40:01,570 --> 00:40:06,810
+واحدة، substance واحدة، مادة واحدة. هذه المادة لها
+
+488
+00:40:06,810 --> 00:40:10,850
+constant composition، يعني لها exact concentration،
+
+489
+00:40:10,850 --> 00:40:16,690
+لها تركيز معين، مثلاً الـ Kit تبع السكر بيجي مع
+
+490
+00:40:16,690 --> 00:40:21,410
+الـ Standard، هذا الـ Standard جواه محلول، جواه السكر
+
+491
+00:40:22,300 --> 00:40:27,220
+بيكون موجود جوة السكر، وهذا السكر بيكون له تركيز
+
+492
+00:40:27,220 --> 00:40:36,340
+معين، ويستخدم الـ Standard من أجل معرفة تركيز عينة
+
+493
+00:40:36,340 --> 00:40:40,620
+unknown، عينة مجهولة. هذا اشتغلته في سنة ثانية لما
+
+494
+00:40:40,620 --> 00:40:44,840
+عملتُ فحص السكر. كان عندكوا استخدمتوا standard السكر
+
+495
+00:40:44,840 --> 00:40:51,180
+لما بتستخدمي أنتِ الـ standard بتعرفي تركيز عينة الـ
+
+496
+00:40:51,180 --> 00:40:56,290
+patient اللي هي الـ unknown، هذا الهدف منه. من خلال
+
+497
+00:40:56,290 --> 00:41:03,350
+معرفة تركيز الـ Standard بقدر أعرف تركيز السكر
+
+498
+00:41:03,350 --> 00:41:07,010
+اللي موجود في عينات الـ Patient. طبعاً الـ Standard
+
+499
+00:41:07,010 --> 00:41:11,190
+لأنه بيحتوي على مادة واحدة، فالـ Purity تبعته
+
+500
+00:41:11,190 --> 00:41:15,080
+عالية، نقاوته عالية. أما الـ Calibrator، Similar to
+
+501
+00:41:15,080 --> 00:41:20,040
+Standard، هو نفس الـ Standard بالضبط، لكن مش Pure،
+
+502
+00:41:20,040 --> 00:41:23,840
+مش نقي، لأن الـ Calibrator عادة بتكون من Multiple
+
+503
+00:41:23,840 --> 00:41:29,160
+Substances، من أكثر من مادة. الـ Calibrator بتكون من
+
+504
+00:41:29,160 --> 00:41:32,820
+أكثر من مادة مع بعض، solution بيحتوي على أكثر من
+
+505
+00:41:32,820 --> 00:41:37,940
+مادة، وكل مادة إلها Exact Concentration، إلها تركيز
+
+506
+00:41:37,940 --> 00:41:44,520
+معين. الـ Interpretation of Quality Control Charts
+
+507
+00:41:44,520 --> 00:41:49,960
+طبعاً بدنا نحكي معلومة أنه أنا مثلاً كمختبر أو
+
+508
+00:41:49,960 --> 00:41:55,980
+كمستشفى، كل يوم قبل ما أشبك عينات المرضى على الجهاز
+
+509
+00:41:55,980 --> 00:42:01,680
+لازم أشتغل control، أجيب عينات control، أعملها فحص
+
+510
+00:42:01,680 --> 00:42:06,040
+السكر وفحص البروتين وكل الفحصات، أطلبها كل الفحصات
+
+511
+00:42:06,040 --> 00:42:11,910
+على الجهاز وأشتغلها وأطلع نتائجها، وأشوف كيف نتائج
+
+512
+00:42:11,910 --> 00:42:15,850
+الـ Control. بعد ما أتأكد إن نتائج الـ Control كلها
+
+513
+00:42:15,850 --> 00:42:21,610
+سليمة وصحيحة وبعطيني نتائج تمام، بروح بشبك عينات
+
+514
+00:42:21,610 --> 00:42:26,990
+المرضى على الجهاز، وأنا مضطرة هالجيت نتائج الـ
+
+515
+00:42:26,990 --> 00:42:31,930
+Control اللي بتطلع. هذه إحنا لازم نمثلها على الـ
+
+516
+00:42:31,930 --> 00:42:36,260
+Chart، نمثلها على رسمة، عشان أنا بدي أعمل
+
+517
+00:42:36,260 --> 00:42:40,660
+Interpretation، بدي أعمل تحليل لنتائج الـ Control
+
+518
+00:42:40,660 --> 00:42:46,660
+اللي أنا بشبكها كل يوم، لأن هذا واجب، واجب ومطلوب
+
+519
+00:42:46,660 --> 00:42:50,320
+منها، لأن مثلاً وزارة الصحة تيجي حملة تفتيش على
+
+520
+00:42:50,320 --> 00:42:56,580
+المختبر كل شهر، كل شهر بتبقى ترسميه Chart، ترسميه
+
+521
+00:42:56,580 --> 00:43:01,770
+شكل، تمثّل فيه نتائج الـ Control اللي طلعت معك على
+
+522
+00:43:01,770 --> 00:43:06,350
+مدار الشهر. مش احنا اتفقنا كل يوم بدك تشبكي Control
+
+523
+00:43:06,350 --> 00:43:11,250
+وتشتغلي عينة الـ Control قبل ما تبدأي تشتغلي عينة الـ
+
+524
+00:43:11,250 --> 00:43:16,790
+patient، على مدار الثلاثين يوم، بعد ما تخلصي اليوم
+
+525
+00:43:16,790 --> 00:43:21,880
+الأخير، يوم لما تخلصي بتجمعي نتائج الـ Control مثلاً
+
+526
+00:43:21,880 --> 00:43:26,500
+لفحص السكر وبتروحي ترسميها على منحنى، هذا المنحنى
+
+527
+00:43:26,500 --> 00:43:31,980
+اسمه "Levy-Jennings Control Chart"، بيخص نتائج الـ
+
+528
+00:43:31,980 --> 00:43:35,500
+Control، وهذا المنحنى هو الـ most widely used
+
+529
+00:43:35,500 --> 00:43:39,680
+technique، هو الأكثر انتشاراً واستخداماً، عندنا منحنيات
+
+530
+00:43:39,680 --> 00:43:44,380
+أخرى، بس هو الأكثر استخداماً. الكلام اللي تحت محكيه
+
+531
+00:43:44,380 --> 00:43:49,530
+هذا، إحنا هنحكيه على الرسمة بالـ slide الثانية. هذا
+
+532
+00:43:49,530 --> 00:43:53,630
+اللي أمامنا هو الـ Levy-Jennings Chart، هذا الـ Chart
+
+533
+00:43:53,630 --> 00:43:59,990
+المنحنى، وهذه النتائج هي نتائج لفحص السكر على مدار
+
+534
+00:43:59,990 --> 00:44:06,550
+20 يوم. على الـ X-axis هذا المنحنى لازم أحط الأيام،
+
+535
+00:44:06,550 --> 00:44:10,870
+اليوم الأول، اليوم الثاني، ثلاثة، أربعة، خمسة،
+
+536
+00:44:10,870 --> 00:44:15,890
+ستة، لحد اليوم العشرين. على الـ Y Axis في المنتصف
+
+537
+00:44:15,890 --> 00:44:20,150
+باجي وبحط الـ mean، الـ mean هو الـ X Bar، الوسط
+
+538
+00:44:20,150 --> 00:44:25,290
+الحسابي. الوسط الحسابي قانونه مجموع القيم على عددها،
+
+539
+00:44:25,290 --> 00:44:30,930
+أي قيم؟ قيم السكر اللي طلعتها خلال عشرين يوم. مش
+
+540
+00:44:30,930 --> 00:44:34,790
+اتفقنا في أول يوم، في اليوم الأول شبكت الـ control
+
+541
+00:44:34,790 --> 00:44:39,990
+وطلعت نتيجة السكر له، بسجلها. في اليوم الثاني بشتغل
+
+542
+00:44:39,990 --> 00:44:44,350
+الـ control برضه، وبسجل نتيجة السكر له. في اليوم
+
+543
+00:44:44,350 --> 00:44:48,790
+الثالث برضه بشتغل الـ control، وبشتغله فحص السكر، و
+
+544
+00:44:48,790 --> 00:44:55,570
+بسجل نتيجته. إذا صار عندي عشرين نتيجة للسكر، بروح
+
+545
+00:44:55,570 --> 00:45:00,990
+أجمع العشرين قيمة على عددهم، وبطلّع الـ X bar أو ما
+
+546
+00:45:00,990 --> 00:45:05,450
+يسمّى الـ mean، الوسط الحسابي. وهذول العشرين قيمة
+
+547
+00:45:05,450 --> 00:45:09,550
+برضه بروح أحسب لهم الـ standard deviation، مقدار
+
+548
+00:45:09,550 --> 00:45:16,150
+التشتت، بالقانون اللي أنتم عارفينه. بعدين بروح أحسب الـ
+
+549
+00:45:16,150 --> 00:45:21,610
+statistical limit، الحدود اللي فوق الـ mean واللي تحت
+
+550
+00:45:21,610 --> 00:45:28,250
+الـ mean. فوق الـ mean: +1، هذا عبارة عن كيف
+
+551
+00:45:28,250 --> 00:45:34,560
+بحسبه؟ بروح أجيب الـ mean زائد واحد standard
+
+552
+00:45:34,560 --> 00:45:41,120
+deviation، بتجيبي الوسط الحسابي وبتجمعي له واحد ضرب
+
+553
+00:45:41,120 --> 00:45:46,860
+الـ standard deviation اللي حسبتيه فوق. X bar زائد
+
+554
+00:45:46,860 --> 00:45:53,330
+اتنين SD. الوسط الحسابي بتجمعيه للـ Standard
+
+555
+00:45:53,330 --> 00:45:59,570
+Deviation مضروب في 2. فوق X bar زائد 3SD، الوسط
+
+556
+00:45:59,570 --> 00:46:05,170
+الحسابي بتجمعيه لـ 3 مضروب في الـ Standard
+
+557
+00:46:05,170 --> 00:46:14,580
+Deviation. تحت الـ mean عندي -1S، -2S، -3S. برضه بتجيبي
+
+558
+00:46:14,580 --> 00:46:19,400
+الوسط الحسابي وبتطرحي منه واحد standard deviation،
+
+559
+00:46:19,400 --> 00:46:22,220
+واحد standard deviation. كلكم عارفين واحد ضرب
+
+560
+00:46:22,220 --> 00:46:26,000
+standard deviation. بعدين بتجيبي X bar، الوسط
+
+561
+00:46:26,000 --> 00:46:30,200
+الحسابي، بتطرحي منه الـ standard deviation مضروب في
+
+562
+00:46:30,200 --> 00:46:35,120
+اثنين. برضه الوسط الحسابي بتطرحي منه الـ standard
+
+563
+00:46:35,120 --> 00:46:39,780
+deviation مضروب في ثلاثة، وبتجيبي الحدود ما فوق الـ
+
+564
+00:46:39,780 --> 00:46:45,270
+mean وما تحت الـ mean. هذا الـ Chart بنسميه الـ Levy-
+
+565
+00:46:45,270 --> 00:46:50,330
+Jennings Chart. وبعدين بتيجي في اليوم الأول، جْداش طلع
+
+566
+00:46:50,330 --> 00:46:54,890
+مستوى السكر، بتمثّل النقطة. في اليوم الثاني جداش طلع
+
+567
+00:46:54,890 --> 00:46:58,830
+مستوى السكر، بتمثّل النقطة زي ما هو ممثل. وفي اليوم
+
+568
+00:46:58,830 --> 00:47:02,970
+الثالث والرابع وهكذا، وبعد هيك بتوصلي ما بين
+
+569
+00:47:02,970 --> 00:47:09,360
+النقاط. هيك أنا بكون مثّلت نتائج الـ Control خلال
+
+570
+00:47:09,360 --> 00:47:15,180
+عشرين يوم، لفحص السكر مثلاً أو فحص Enzyme، على منحنى
+
+571
+00:47:15,180 --> 00:47:20,160
+الـ Levy-Jennings Chart. بهاي الـ slide بس بدي إياكوا
+
+572
+00:47:20,160 --> 00:47:24,080
+تعرفوا كيف بنحسب الـ mean، الوسط الحسابي، مجموع
+
+573
+00:47:24,080 --> 00:47:28,460
+القيم على عددها، وكيف بنحسب مقدار التشتت، الـ Standard
+
+574
+00:47:28,460 --> 00:47:32,080
+Deviation، بالقانون اللي اخذته بالإحصاء. Coefficient
+
+575
+00:47:32,080 --> 00:47:37,750
+of variation ما بدنا إياه. هالجيت أنا بعد ما مثّلت
+
+576
+00:47:37,750 --> 00:47:41,630
+نتائج الـ Control على الـ Levy-Jennings Chart،
+
+577
+00:47:41,630 --> 00:47:48,330
+بدي أبدأ أشوف أنا عندي عشرين يوم وعشرين نتيجة على
+
+578
+00:47:48,330 --> 00:47:53,110
+المنحنى، بدي أشوف وين في نتائج فيها مشاكل، وين في
+
+579
+00:47:53,110 --> 00:47:58,950
+نتائج كانت ضمن الوضع الطبيعي للـ Control. هالجيت في
+
+580
+00:47:58,950 --> 00:48:04,590
+شغل اسمها الـ Westgard Multi-Rule Procedure، قواعد
+
+581
+00:48:04,590 --> 00:48:09,570
+اسمها Westgard Rules. هذه القواعد بتخص نتائج الـ
+
+582
+00:48:09,570 --> 00:48:14,870
+control اللي احنا مثّلناها على المنحنى. فعلياً هي
+
+583
+00:48:14,870 --> 00:48:21,110
+six basic rules، هي ست قواعد، في أكثر بس فعلياً هي ست
+
+584
+00:48:21,110 --> 00:48:26,050
+قواعد اسمها Westgard. هذه القواعد أنا ممكن أستخدمها
+
+585
+00:48:26,050 --> 00:48:30,690
+individually، يعني أستخدم قاعدة واحدة فردية، or in
+
+586
+00:48:30,690 --> 00:48:35,910
+combination، أستخدم أكثر من قاعدة. والهدف منها عشان
+
+587
+00:48:35,910 --> 00:48:41,550
+أقيم نتائج الـ control وأعمل interpretation، تحليل
+
+588
+00:48:41,550 --> 00:48:47,500
+لنتائج الـ control. معظم الـ Quality Control Rules،
+
+589
+00:48:47,500 --> 00:48:53,180
+معظم هذه القواعد تبعت الـ Control، بتم التعبير عنها
+
+590
+00:48:53,180 --> 00:48:59,760
+بإشارة اسمها NL. N جاية من number، وL جاية من
+
+591
+00:48:59,760 --> 00:49:05,540
+statistical limit، تمام؟ N number، إيه؟ يعني number
+
+592
+00:49:05,540 --> 00:49:15,990
+شو؟ الـ N number هو عدد القيم اللي فيهم مشكلة، تمام؟
+
+593
+00:49:15,990 --> 00:49:23,070
+الـ N هي عدد القيم اللي فيهم مشكلة، قيم مين؟ قيم
+
+594
+00:49:23,070 --> 00:49:29,670
+الـ control. بمعنى آخر، عدد نتائج الـ control اللي
+
+595
+00:49:29,670 --> 00:49:36,030
+فيها المشكلة. الـ L هي الـ statistical limit، نوضحها
+
+596
+00:49:36,030 --> 00:49:43,910
+أكثر بمثال. لو حكيت لك عندي قاعدة، القاعدة اسمها 13S،
+
+597
+00:49:43,910 --> 00:49:50,780
+تمام، هذه القاعدة كيف بدي أعملها؟ الواحد هذا بيعبّر
+
+598
+00:49:50,780 --> 00:49:57,300
+عن n، يعني عندي واحد، يعني عندي قيمة واحدة من قيم
+
+599
+00:49:57,300 --> 00:50:03,140
+الـ control فيها مشكلة. ثلاثة S، S معناها SD، للـ
+
+600
+00:50:03,140 --> 00:50:07,640
+Standard Deviation. ثلاثة Standard Deviation، معناه
+
+601
+00:50:07,640 --> 00:50:11,920
+هذا الـ statistical limit، الحدود الإحصائية. إذن
+
+602
+00:50:11,920 --> 00:50:18,850
+معظم قواعد الخاصة بـ نتائج الـ Control بتم التعبير
+
+603
+00:50:18,850 --> 00:50:26,550
+عنها برقم وحد إحصائي NL. الرقم بيعبر عن عدد النتائج
+
+604
+00:50:26,550 --> 00:50:30,610
+تبع الـ Control اللي فيها مشكلة. أكثر نتيجة من نتائج
+
+605
+00:50:30,610 --> 00:50:35,750
+الـ Control فيها مشكلة، نتيجة، نتيجتين، ثلاث نتائج؟
+
+606
+00:50:35,750 --> 00:50:39,730
+زي هنا واحد، ثلاث أس، نتيجة واحدة من نتائج الـ
+
+607
+00:50:39,730 --> 00:50:45,090
+Control فيها خلل. ثلاثة أس، معنى الكلام إيش؟ ثلاثة أس،
+
+608
+00:50:45,090 --> 00:50:49,250
+هذا الحدود الإحصائي، ثلاثة standard deviation، تمام؟
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/v_VgjVkzGH0_postprocess.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/v_VgjVkzGH0_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..16aa459352b201eb6c2b244a14c3b3514c35769b
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/v_VgjVkzGH0_postprocess.srt
@@ -0,0 +1,2432 @@
+1
+00:00:01,210 --> 00:00:04,850
+السلام عليكم ورحمة الله وبركاته يعطيكم العافية
+
+2
+00:00:04,850 --> 00:00:09,150
+جميعا ان شاء الله اليوم محاضرتنا بعنوان quality
+
+3
+00:00:09,150 --> 00:00:15,280
+control مراقبة الجودةهنا بدنا نحكي عن الـ Quality
+
+4
+00:00:15,280 --> 00:00:21,360
+Assurance برنامج ضمان الجودة بدنا نتعرف أول إشي
+
+5
+00:00:21,360 --> 00:00:33,440
+على تعريف ضمان الجودة عبارة عن برنامج
+
+6
+00:00:33,440 --> 00:00:41,130
+ضمان الجودة هو عبارة عنمجموعة من الخطوات المترابطة
+
+7
+00:00:41,130 --> 00:00:48,050
+التي يجب على الـ Lab Technician يعني أخصاء التحليل
+
+8
+00:00:48,050 --> 00:00:54,890
+اتباعها من أجل إعطاء أفضل خدمةلـ patient و ال
+
+9
+00:00:54,890 --> 00:01:00,330
+physician أنا ك lab technician كخصائي تحليل كيف
+
+10
+00:01:00,330 --> 00:01:04,670
+أنا ممكن أقدم أفضل خدمة لل patient و ال physician
+
+11
+00:01:04,670 --> 00:01:11,230
+أفضل خدمة أقصد فيها إعطاء result صحيحة right
+
+12
+00:01:11,230 --> 00:01:17,100
+resultالـ patient يعني أنا بعمل التحليل واجبي أعطي
+
+13
+00:01:17,100 --> 00:01:22,540
+نتائج صحيحة right result للمريض و لل physician و
+
+14
+00:01:22,540 --> 00:01:28,780
+للدكتور عشان في الآخر الدكتور يعطي decision قرار
+
+15
+00:01:28,780 --> 00:01:33,160
+بي ل treatmentالـ Quality Assurance هذا برنامج
+
+16
+00:01:33,160 --> 00:01:38,000
+كبير is a complete system عبارة عن نظام معقد which
+
+17
+00:01:38,000 --> 00:01:44,620
+contain quality control كلنا بنسمع بـ مراقبة
+
+18
+00:01:44,620 --> 00:01:48,560
+الجودة مراقبة الجودة اللي هو الـ Quality Control
+
+19
+00:01:48,560 --> 00:01:54,600
+يعتبر جزء من برنامج ضمان الجودة اللي هو الـ
+
+20
+00:01:54,600 --> 00:01:57,500
+Quality Assurance الـ Quality Assurance هو
+
+21
+00:01:57,500 --> 00:02:04,330
+البرنامج الكبير اللي بيضمControl تعريف آخر للـ
+
+22
+00:02:04,330 --> 00:02:09,230
+Quality Assurance Right Result إعطاء نتائج صحيحة
+
+23
+00:02:10,090 --> 00:02:14,250
+تحليل صحيحة at right time بكفيش أنا أعطي نتيجة
+
+24
+00:02:14,250 --> 00:02:19,670
+صحيحة لازم أعطلها في الوقت المناسب يعني أطلع نتيجة
+
+25
+00:02:19,670 --> 00:02:24,850
+التحليل بسرعة ما ياخد معي التحليل وقت on right
+
+26
+00:02:24,850 --> 00:02:29,870
+specimen لما بدي أجي أشتغل على عينة صحيحة مجموعة
+
+27
+00:02:29,870 --> 00:02:35,090
+بطريقة صحيحة بـ Anticoagulant مطلوب مأخوذة من ال
+
+28
+00:02:35,090 --> 00:02:40,220
+right patientمن الـ Patient الصحيح اللي مطلوب له
+
+29
+00:02:40,220 --> 00:02:41,120
+التحليل
+
+30
+00:02:45,240 --> 00:02:48,360
+عرفنا الـ Quality Assurance اللي هو الـ Complete
+
+31
+00:02:48,360 --> 00:02:54,580
+System النظام الكامل المعقد اللذي يضم عدة برامج
+
+32
+00:02:54,580 --> 00:02:58,920
+طبعاً الـ GitHub عرف اللي هو الـ Quality Control
+
+33
+00:02:58,920 --> 00:03:02,860
+اللي هو جزء من الـ Quality Assurance الـ Quality
+
+34
+00:03:02,860 --> 00:03:07,720
+Control مراقبة الجودة هو عبارة عن الـ process of
+
+35
+00:03:07,720 --> 00:03:10,620
+monitoring the accuracy and precision of
+
+36
+00:03:10,620 --> 00:03:14,670
+laboratory tests with control samplesهو عبارة عن
+
+37
+00:03:14,670 --> 00:03:21,510
+عملية متابعة لصحة وضقة النتائج اللي بيطلعها
+
+38
+00:03:21,510 --> 00:03:28,330
+المختبر من خلال استخدام عينة Control أثناء أداء
+
+39
+00:03:28,330 --> 00:03:32,990
+الفحوصات هالجيت لو أنا بدي أجي جاني بشنق مريض بدي
+
+40
+00:03:32,990 --> 00:03:38,290
+يعني أعمله فحص سكر لازم أمشي مع عينته عينة Control
+
+41
+00:03:39,000 --> 00:03:42,220
+لو إجاني شخص بدي يعمل فحص الـ Total Protein أو
+
+42
+00:03:42,220 --> 00:03:48,300
+Enzyme أو أي test في الكيميا لازم أناشي control
+
+43
+00:03:48,300 --> 00:03:54,980
+إذن مراقبة الجودة هي عملية متابعة لمدى صحة وضقة
+
+44
+00:03:55,350 --> 00:04:01,150
+النتائج اللي بيطلعها المختبر من خلال استخدام يعني
+
+45
+00:04:01,150 --> 00:04:07,710
+أنا بشيك على صحة ونتائج على صحة وضقة النتائج اللي
+
+46
+00:04:07,710 --> 00:04:16,160
+بيطلعها المختبر من خلال اني بمشي عينة controlبمشي
+
+47
+00:04:16,160 --> 00:04:22,580
+عينة control مع شغلي عشان أشيك على شغله تعريف آخر
+
+48
+00:04:22,580 --> 00:04:26,580
+للـ Quality Control الـ statistical process used
+
+49
+00:04:26,580 --> 00:04:30,460
+to monitor and evaluate analytical process that
+
+50
+00:04:30,460 --> 00:04:35,820
+produces patient results هي عبارة عن عملية إحصائية
+
+51
+00:04:36,380 --> 00:04:41,480
+عادة أنا بستخدم الـ Quality Control مراقبة الجودة
+
+52
+00:04:41,480 --> 00:04:48,320
+من أجل متابعة and تقييم من أجل المتابعة وتقييم
+
+53
+00:04:48,320 --> 00:04:53,820
+العملية التحليلية أثناء تحليل الفحص That produces
+
+54
+00:04:53,820 --> 00:05:00,150
+the patient resultsاللي هي أثناء العملية التحليلية
+
+55
+00:05:00,150 --> 00:05:05,690
+اللي بدي تم من خلالها إعطاء نتائج لـ patient نتيجة
+
+56
+00:05:05,690 --> 00:05:10,490
+التحليل إذا بدي أفهم من التعريف إنه الـ Quality
+
+57
+00:05:10,490 --> 00:05:15,730
+Control يتم تطبيقهأثناء أو في مرحلة الـ Analytical
+
+58
+00:05:15,730 --> 00:05:18,750
+phase إحنا المرحلة التحليلية تقسم لتلت أقسام
+
+59
+00:05:18,750 --> 00:05:23,970
+Analytical، Pre Analytical و Analytical and Post
+
+60
+00:05:23,970 --> 00:05:27,050
+Analytical ما قبل التحليل، أثناء التحليل، بعد
+
+61
+00:05:27,050 --> 00:05:31,970
+التحليل برنامج مراقبة الجودة يتم تطبيقه في الـ
+
+62
+00:05:31,970 --> 00:05:35,690
+Analytical process في عملية التحليل أنا أثناء مبجر
+
+63
+00:05:35,690 --> 00:05:41,090
+الفحص بمشي مع عينة control عشان أشيك على نتائج ال
+
+64
+00:05:41,090 --> 00:05:46,380
+patient butالـ Quality Assurance البرنامج الكبير
+
+65
+00:05:46,380 --> 00:05:52,740
+هذا البرنامج يتم تطبيقه في الثلاث مراحل عشان هيك
+
+66
+00:05:52,740 --> 00:05:57,020
+هو برنامج شامل كامل يتم تطبيقه في الـ Pre
+
+67
+00:05:57,020 --> 00:06:00,620
+-analytical والـ Analytical والـ Post-analytical
+
+68
+00:06:00,620 --> 00:06:06,110
+لأن البرنامج الكبير مجموعة خطوات مترابطةلو أنا
+
+69
+00:06:06,110 --> 00:06:11,230
+كـLab Technician اتبعت برنامج ضمان الجودة من أول
+
+70
+00:06:11,230 --> 00:06:15,490
+ما استلمت العينة لحد ما سجلت النتيجة مش هنجع في
+
+71
+00:06:15,490 --> 00:06:19,150
+الخطأ الـQuality Control يتم تطبيقه في الـ
+
+72
+00:06:19,150 --> 00:06:22,730
+Analytical Phase أما الـQuality Assurance بتتم
+
+73
+00:06:22,730 --> 00:06:26,270
+تطبيقه في التلت مراحل في الـPre Analytical،
+
+74
+00:06:26,270 --> 00:06:29,780
+Analytical، Post Analyticalبتلاقي وزارة الصحة
+
+75
+00:06:29,780 --> 00:06:34,300
+شركات بتحطلك بروتوكولات معينة لقالي تجمع العينة
+
+76
+00:06:34,300 --> 00:06:38,100
+أثناء التحليل أيضا ما بعد التحليل لما تيجي تسجل
+
+77
+00:06:38,100 --> 00:06:42,440
+العينة وتخرجيها، اذا هذا كله برنامج كامل يعني
+
+78
+00:06:42,440 --> 00:06:47,540
+الهدف منه بتطلع نتيجة صحيحةبدنا نحكي عن الـ
+
+79
+00:06:47,540 --> 00:06:50,640
+Quality Control Types أنواع الـ Quality Control
+
+80
+00:06:50,640 --> 00:06:54,260
+نوعين اللي هو الـ Internal Quality Control مراقبة
+
+81
+00:06:54,260 --> 00:06:57,920
+جودة داخلية والـ External Quality Control مراقبة
+
+82
+00:06:57,920 --> 00:07:02,020
+جودة خارجية بالبداية الـ Internal Quality Control
+
+83
+00:07:02,020 --> 00:07:05,980
+شو تعريفها؟ is a procedure for utilizing the
+
+84
+00:07:05,980 --> 00:07:10,280
+results of only one laboratory for quality control
+
+85
+00:07:10,280 --> 00:07:16,820
+purposeهو عبارة عن إجراء لاستخدام نتائج مختبر واحد
+
+86
+00:07:16,820 --> 00:07:24,440
+فقط لغرض مراقبة الجودة بمفهوم أبسط من هيكالـ
+
+87
+00:07:24,440 --> 00:07:28,220
+Internal Quality Control معناه أنا كمختبر أو
+
+88
+00:07:28,220 --> 00:07:34,420
+كمستشفة لازم كل يوم مع فحوصاتي أمشي عينة الـ
+
+89
+00:07:34,420 --> 00:07:37,720
+control مع نتائج ال patient يعني إجاني مريض بدي
+
+90
+00:07:37,720 --> 00:07:41,600
+يفحص السكر بدي أمشي بدي أمشي مع فحص السكر control
+
+91
+00:07:41,600 --> 00:07:44,720
+بدي أفحص الـ total protein بدي أمشي مع الـ total
+
+92
+00:07:44,720 --> 00:07:49,180
+protein control هذا ال control عادة بيجي من الشركة
+
+93
+00:07:49,180 --> 00:07:53,790
+إما powder أو liquid سائدوبيكون معاه أيضًا ورقة
+
+94
+00:07:53,790 --> 00:07:59,710
+بانفلة فيها الـ Normal Range لكل فحص السكر مثلًا
+
+95
+00:07:59,710 --> 00:08:03,830
+من 70 ل110 Total Protein من 6 ل 8 gram per
+
+96
+00:08:03,830 --> 00:08:08,250
+deciliter بيكون مكتوب فيه الـ Range لجميع الفحصات
+
+97
+00:08:08,250 --> 00:08:12,630
+أنا عليا كل يوم أمشي مع عينات ال patient عينات ال
+
+98
+00:08:12,630 --> 00:08:16,230
+control هذا بسميه Internal Quality Control بيكون
+
+99
+00:08:16,230 --> 00:08:20,910
+على نطاق one laboratory على نطاق المختبر الواحد
+
+100
+00:08:20,910 --> 00:08:25,810
+butالـ External Quality Control مراقبة الجودة
+
+101
+00:08:25,810 --> 00:08:30,150
+الخارجية هو إجراء إن عرفوا بالإنجليزي is a
+
+102
+00:08:30,150 --> 00:08:32,950
+procedure for utilizing for quality control
+
+103
+00:08:32,950 --> 00:08:36,950
+purposes the results of several laboratories which
+
+104
+00:08:36,950 --> 00:08:41,510
+analyze the same specimens several laboratories
+
+105
+00:08:41,510 --> 00:08:48,680
+إيش يعني؟هو عبارة عن إجراء لاستخدام نتائج أكثر من
+
+106
+00:08:48,680 --> 00:08:56,220
+مختبر فقط لغرض مراقبة الجودة إيش يعني الفرج إنه
+
+107
+00:08:56,220 --> 00:09:02,310
+فوق في الـ Internal على مستوى نطاق مختبر واحدالـ
+
+108
+00:09:02,310 --> 00:09:06,890
+External Quality Control مجموعة من المختبرات يعني
+
+109
+00:09:06,890 --> 00:09:10,730
+several laboratories بديوا يصير نظام منافسة مثلا
+
+110
+00:09:10,730 --> 00:09:15,450
+أكتر من مستشفى بتيجي وزارة الصحة أو شركات صحية
+
+111
+00:09:15,450 --> 00:09:21,630
+بتجيب عينات Control تمام؟ بتوزعها على المستشفيات
+
+112
+00:09:21,630 --> 00:09:27,220
+هذه عينات الـ Controlبتتعامل معها المستشفى كأنها
+
+113
+00:09:27,220 --> 00:09:32,800
+عينة unknown كأنها عينة مجهولة مش معروفة ومثلا
+
+114
+00:09:32,800 --> 00:09:37,980
+وزارة الصحة بتطلب من جميع المستشفيات ياخدوا هذه
+
+115
+00:09:37,980 --> 00:09:42,960
+العينة ويحللوها ويعملوا لها تحليل لمستوى السكر
+
+116
+00:09:42,960 --> 00:09:48,040
+بتحلل المستشفيات بتستخدم هذه العينة وبتطلع نتيجة
+
+117
+00:09:48,040 --> 00:09:53,930
+السكر وبتطبع النتيجة وبتسلمها لوزارة الصحةوزارة
+
+118
+00:09:53,930 --> 00:10:00,970
+الصحة بدها تشوف هل هذه المستشفى بتطلع نتائج سليمة
+
+119
+00:10:00,970 --> 00:10:04,790
+ولا لأ؟ هتطلع فيه مستشفيات هتطلع مستوى السكر صح،
+
+120
+00:10:04,790 --> 00:10:08,290
+فيه مستشفيات لأ ممكن يكون عندها خلل في الجهاز، في
+
+121
+00:10:08,290 --> 00:10:12,970
+الـreagent هنا مين بيعرف الـnormal range للسكر فقط
+
+122
+00:10:12,970 --> 00:10:18,720
+وزارة الصحة؟المستشفى ما بتكون عندها أي ورقة بالـ
+
+123
+00:10:18,720 --> 00:10:22,300
+Normal Range تبع الـ Control اللي جايبها وزارة
+
+124
+00:10:22,300 --> 00:10:26,820
+الصحة إذاً الـ External Quality Control ما هو إلا
+
+125
+00:10:26,820 --> 00:10:35,080
+نظام منافسةبين المستشفيات ومراقبة للمستشفيات من
+
+126
+00:10:35,080 --> 00:10:41,460
+قبل وزارة الصحة وشركات الصحية عساس لو المستشفى
+
+127
+00:10:41,460 --> 00:10:46,040
+طلعت نتيجة صحيحة أو مختبر طلع نتيجة صحيحة للعينة
+
+128
+00:10:46,040 --> 00:10:50,680
+المجهولة إذا هذا مختبر يعني معتمد بتصير وزارة
+
+129
+00:10:50,680 --> 00:10:54,640
+الصحة تعطيه accreditation، اعتمادودايمًا بشكروا
+
+130
+00:10:54,640 --> 00:10:57,960
+فيه إن مختبر بيطلع نتائج سليمة وصحيحة ليش لأن
+
+131
+00:10:57,960 --> 00:11:02,740
+وزارة الصحة عملت نظام اختبار للمستشفيات اختبرتهم
+
+132
+00:11:02,740 --> 00:11:08,460
+باعتقهم عينة control مش معروف ال normal range
+
+133
+00:11:08,460 --> 00:11:13,220
+للفحص اللي طلبته الصحة هذا ال external الخارجية
+
+134
+00:11:13,220 --> 00:11:19,220
+على مستوى أكتر من مختبر وأكتر من مستشفىwhen errors
+
+135
+00:11:19,220 --> 00:11:23,040
+occur متى تحدث الأخطاء errors occur when there is
+
+136
+00:11:23,040 --> 00:11:26,320
+a loss of accuracy and precision تحدث الأخطاء
+
+137
+00:11:26,320 --> 00:11:33,020
+عندما نفقد ال accuracy و ال precision صحة و دقة
+
+138
+00:11:33,020 --> 00:11:38,000
+النتائج لو تم فقدها معناه أكيد في عندي خطأ معناه
+
+139
+00:11:38,000 --> 00:11:44,280
+حدث خطأA primary goal of a quality assurance الهدف
+
+140
+00:11:44,280 --> 00:11:50,500
+الأساسي والأولي لبرنامج ضمان الجودة Is to reduce
+
+141
+00:11:50,500 --> 00:11:56,420
+and detect error تقليل وكشف الأخطاء يكشف عن الخطأ
+
+142
+00:11:56,420 --> 00:12:02,440
+ويبقى يقلل من هذا الخطأ Or to obtain the best
+
+143
+00:12:02,440 --> 00:12:05,920
+possible accuracy and precision أيضًا من هدف هذا
+
+144
+00:12:05,920 --> 00:12:14,020
+البرنامج تقديم أفضلصحة ودقة للنتيجة الـ Source of
+
+145
+00:12:14,020 --> 00:12:18,560
+Error مصادر الأخطاء All analytical results are
+
+146
+00:12:18,560 --> 00:12:22,720
+subject to errors arising from a variety of causes
+
+147
+00:12:22,720 --> 00:12:26,140
+but it's short kept to a minimum كل النتائج
+
+148
+00:12:26,140 --> 00:12:32,700
+التحليلية، كل الفحوصات في المختبر معرضة إن يصير
+
+149
+00:12:32,700 --> 00:12:39,280
+فيها أخطاءوهذه الأخطاء زي من أسباب مختلفة لكن أنا
+
+150
+00:12:39,280 --> 00:12:43,140
+ك lab technician بدي أحاول أقلل من حدوث هذه
+
+151
+00:12:43,140 --> 00:12:47,840
+الأخطاء ال errors can occur at various stages in
+
+152
+00:12:47,840 --> 00:12:54,670
+the process الأخطاء تحدثفي مراحل مختلفة من عملية
+
+153
+00:12:54,670 --> 00:12:58,790
+التحليل الأخطاء التحدث في الـ Pre-analytical phase
+
+154
+00:12:58,790 --> 00:13:02,110
+وفي الـ Analytical phase و ال Past Analytical
+
+155
+00:13:02,110 --> 00:13:05,770
+phase في الـ Pre-analytical phase يعني هذه أخطاء
+
+156
+00:13:05,770 --> 00:13:11,490
+تحدث outside the lab خارج المختبر أثناء جمع العينة
+
+157
+00:13:11,490 --> 00:13:15,990
+ال Analytical phase أخطاء تحدث within the lab يعني
+
+158
+00:13:15,990 --> 00:13:20,480
+أثناء التحليل أثناء عملية الفحصأما الـ Post
+
+159
+00:13:20,480 --> 00:13:25,340
+Analytical هذه عبارة عن Error بتحدث مابعد عملية
+
+160
+00:13:25,340 --> 00:13:30,100
+التحليل إيش ال Post Analytical الكاتب عندها؟ The
+
+161
+00:13:30,100 --> 00:13:33,700
+correct result is generated أنا مثلا بكون مطلعة
+
+162
+00:13:33,700 --> 00:13:38,640
+نتائج صحيحة و 100% but is incorrectly recordedin
+
+163
+00:13:38,640 --> 00:13:43,540
+the patient's record لكن المشكلة في عملية التسجيل
+
+164
+00:13:43,540 --> 00:13:47,420
+احنا عارفين معظم مشاكل ال post analytical ما بعد
+
+165
+00:13:47,420 --> 00:13:51,140
+التحليل عملية تسجيل النتيجة أنا بكون انطلع النتيجة
+
+166
+00:13:51,140 --> 00:13:56,620
+صح بس نجلاها في السجل أو بعتها للدكتور كتبها خطأ
+
+167
+00:13:56,620 --> 00:14:02,710
+دخلاها على ال lab خطأ تمام؟الـ True Analytical
+
+168
+00:14:02,710 --> 00:14:06,890
+Errors are those which occur during the actual
+
+169
+00:14:06,890 --> 00:14:09,850
+performance of the analysis which can be
+
+170
+00:14:09,850 --> 00:14:14,290
+classified into systematic error and random error
+
+171
+00:14:14,290 --> 00:14:19,550
+بيحكيلي الأخطاء التحليلية الحقيقية هي اللي بتحدث
+
+172
+00:14:19,550 --> 00:14:27,030
+أثناء العملية التحليلية أثناءالشغل الحقيقي الـ
+
+173
+00:14:27,030 --> 00:14:31,350
+Actual Performance الأداء الحقيقي للتحليل يعني
+
+174
+00:14:31,350 --> 00:14:36,590
+أثناء ما أنت بتحلل العينة هذه أخطاء حقيقية جوهرية
+
+175
+00:14:36,590 --> 00:14:41,350
+أثناء التحليل اللي بتحدث وتقسم الأخطاء إلى قسمين
+
+176
+00:14:41,350 --> 00:14:46,610
+Systematic Error خطأ منهجي and Random Error خطأ
+
+177
+00:14:46,610 --> 00:14:52,450
+عشوائيالـ Systematic Errors الخطأ المنهجي on
+
+178
+00:14:52,450 --> 00:14:56,330
+repeated analysis of the sample we may also find
+
+179
+00:14:56,330 --> 00:15:00,570
+values at wrong level too high or too low بحكي
+
+180
+00:15:00,570 --> 00:15:04,490
+للخطأ المنهجي بدي أتعرف عليه كيف لو جبتي عينة
+
+181
+00:15:04,490 --> 00:15:10,820
+controlواشتغلتي لها فحص السكر وطلعتي نتيجتها وبعد
+
+182
+00:15:10,820 --> 00:15:14,360
+ساعة قعدت الفحص كمان مرة اشتغلتي لها فحص السكر
+
+183
+00:15:14,360 --> 00:15:18,560
+وسجلت النتيجة بعد ساعة قعدت الفحص كمان مرة اذا
+
+184
+00:15:18,560 --> 00:15:22,600
+تعملي repeated analysis مثلا فحصت عينة ال control
+
+185
+00:15:22,600 --> 00:15:28,270
+عشر مرات عملتلها فحص السكر خلال اليوملو شغلي تمام
+
+186
+00:15:28,270 --> 00:15:33,850
+ووضعي كله تمام يفترض العشر نتائج اللي طلعوا يكونوا
+
+187
+00:15:33,850 --> 00:15:36,910
+جراب من بعض مثلا بحدود السبعينات، سبعين، خمسة
+
+188
+00:15:36,910 --> 00:15:41,110
+وسبعين، تلاتة وسبعين، تسعة وسبعين لكن في العشر
+
+189
+00:15:41,110 --> 00:15:45,790
+نتائج اللي طلعوالو لجتما النتائج صحيحة إجراب من
+
+190
+00:15:45,790 --> 00:15:51,810
+بعض ونتشتين كانوا يعني wrong value قيم خاطئا بينين
+
+191
+00:15:51,810 --> 00:15:56,550
+كتير بعاد عن النتائج اللي طلعت يعني لو طلعت نتشتين
+
+192
+00:15:56,550 --> 00:16:01,920
+أو أكتر ابعاد عن نتائجي معناه فيه مشكلةمعناه في
+
+193
+00:16:01,920 --> 00:16:07,100
+خطأ منهجي نتيجتين أو أكتر فيهم مشكلة معناه في عندي
+
+194
+00:16:07,100 --> 00:16:11,940
+خطأ منهجي ممكن يطلع هذه النتائج أو هذه النتائج
+
+195
+00:16:11,940 --> 00:16:15,820
+الخاطئة اللي طلعت بعيدة ممكن تكون too high، كتير
+
+196
+00:16:15,820 --> 00:16:20,420
+عالية مثلا يطلع السكر 200، 300 أو too low يطلع
+
+197
+00:16:20,420 --> 00:16:25,500
+السكر 40، 20، 10 والعينة بدنا نتفج أنها طبيعية
+
+198
+00:16:25,500 --> 00:16:33,480
+سكرها من 70 ل110وعملت فحص السكر لعينة control عشر
+
+199
+00:16:33,480 --> 00:16:39,680
+مرات تم النتائج صحيحة ونتجتين طلعوا كتير بعد سواء
+
+200
+00:16:39,680 --> 00:16:44,440
+عليين أو واطين معناه في عندي systematic error خطأ
+
+201
+00:16:44,440 --> 00:16:49,410
+منهجينWhich can be due to قد تكون أسبابه
+
+202
+00:16:49,410 --> 00:16:53,150
+analytical method مشكلة في طريقة التحليل أو ال
+
+203
+00:16:53,150 --> 00:16:57,830
+technical performance في أداء أخصاء التحليل في
+
+204
+00:16:57,830 --> 00:17:01,390
+طريقة شغله مشكلة في ال reagent مشكلة في ال
+
+205
+00:17:01,390 --> 00:17:04,430
+measuring equipment في المعدات المستخدمة في
+
+206
+00:17:04,430 --> 00:17:08,630
+التحليل و بالأخص ال bybitمشكلة بالـ Technicians
+
+207
+00:17:08,630 --> 00:17:13,010
+نفسه تبع التحليل أخصاء التحليل There are two types
+
+208
+00:17:13,010 --> 00:17:16,370
+of systematic errors عندي نوعين لـ systematic
+
+209
+00:17:16,370 --> 00:17:21,990
+error خطأ ثابت وخطأ متناسب constant error ثابت و
+
+210
+00:17:21,990 --> 00:17:26,130
+الخطأ ال proportional error الخطأ المتناسب ال
+
+211
+00:17:26,130 --> 00:17:31,420
+constant error الخطأ الثابتإيش تعريفه؟ Error in a
+
+212
+00:17:31,420 --> 00:17:34,800
+test system in which the amount of error remains
+
+213
+00:17:34,800 --> 00:17:38,280
+constant throughout the range of the test process
+
+214
+00:17:38,280 --> 00:17:42,580
+هو عبارة عن الخطأ اللي بيصير أثناء عملية التحليل
+
+215
+00:17:42,580 --> 00:17:48,140
+ويبقى ثابت هذا الخطأ ال amount حجمه remains
+
+216
+00:17:48,140 --> 00:17:51,740
+constant عشان هيك سموه الخطأ الثابت حجم هذا الخطأ
+
+217
+00:17:51,740 --> 00:17:58,770
+يبقى ثابتمهما زاد تركيز الـ Analyte اللي أنا بدي
+
+218
+00:17:58,770 --> 00:18:04,050
+أجيسه في العينة لو كان السكر 70 أو كان السكر 80
+
+219
+00:18:04,050 --> 00:18:08,070
+اللي موجود في العينة أو كان السكر تركيزه 100 أو
+
+220
+00:18:08,070 --> 00:18:13,890
+200 أو 300 أو 600 هذا الـ Constant Error مهما زاد
+
+221
+00:18:13,890 --> 00:18:21,120
+تركيز الـ Analyte في العينةيبقى ثابت كما هو وما
+
+222
+00:18:21,120 --> 00:18:25,820
+بيتغير له نسبة ثابتة الـ Constant Error أما الـ
+
+223
+00:18:25,820 --> 00:18:30,520
+Proportional Error الخطأ المتناسب Error in a test
+
+224
+00:18:30,520 --> 00:18:35,500
+system in which the amount of error increases the
+
+225
+00:18:35,500 --> 00:18:39,620
+concentration of the substance being measured هو
+
+226
+00:18:39,620 --> 00:18:45,350
+عبارة عن الخطأ اللي بيصير أثناء عملية التحليلحجم
+
+227
+00:18:45,350 --> 00:18:53,030
+هذا الخطأ يزداد بزيادة تركيز الـ Analyte جوّات
+
+228
+00:18:53,030 --> 00:18:57,430
+العينة إذا الفرق بينه وبين الـ Constant Error إن
+
+229
+00:18:57,430 --> 00:19:01,830
+الـ Proportional Error هذا الخطأ المتناسب ما بيظل
+
+230
+00:19:01,830 --> 00:19:07,870
+ثابت بيزداد حجم هذا الخطأ كل ما زاد تركيز مثلا الـ
+
+231
+00:19:07,870 --> 00:19:11,350
+Analyte اللي هو مثلا السكر اللي موجود في العينة
+
+232
+00:19:11,350 --> 00:19:17,110
+مثلا لو إيجتني عينة سكرها 70الها نسبة خطأ معينة
+
+233
+00:19:17,110 --> 00:19:23,250
+طيب لو زودت تركيز السكر خليته 200 نسبة الخطأ هتزيد
+
+234
+00:19:23,250 --> 00:19:29,730
+إذا نسبة الخطأ تزداد بزيادة تركيز الانالايت اللي
+
+235
+00:19:29,730 --> 00:19:37,140
+أنا بدي أجيسه داخل العينةلو جينا برجع بعيد نفس
+
+236
+00:19:37,140 --> 00:19:41,000
+الكلام بحكي عن الـTypes of Systematic Error عن
+
+237
+00:19:41,000 --> 00:19:44,760
+أنواع الخطأ المنهج حكينا Proportional Error خطأ
+
+238
+00:19:44,760 --> 00:19:49,000
+متناسب and Constant Error وخطأ ثابت بالنسبة
+
+239
+00:19:49,000 --> 00:19:53,320
+لـProportional Error في كمان تعريف لهThe magnitude
+
+240
+00:19:53,320 --> 00:19:57,520
+of the error grows with the concentration of the
+
+241
+00:19:57,520 --> 00:20:03,100
+material being measured هو الخطأ اللي بيزداد تزداد
+
+242
+00:20:03,100 --> 00:20:08,860
+نسبته بزيادة تركيز الانالايت اللي موجود في العينة
+
+243
+00:20:08,860 --> 00:20:13,160
+زي ما احنا شايفين بالرسم الأولى بتعبر عن ال
+
+244
+00:20:13,160 --> 00:20:19,350
+proportional error في عندى علاقة ترضية مابيننسبة
+
+245
+00:20:19,350 --> 00:20:24,010
+الخطأ اللي بتسير وما بين تركيز الانالايت اللي أنا
+
+246
+00:20:24,010 --> 00:20:29,250
+بجيسه جواه العينة كل ما مثلا مكان تركيز السكر أكتر
+
+247
+00:20:29,250 --> 00:20:34,410
+كل ما زاد حجم الخطأ أما لما أحكيلك constant error
+
+248
+00:20:34,410 --> 00:20:39,390
+العكس يعني هذا الخطأ الثابت the magnitude of the
+
+249
+00:20:39,390 --> 00:20:43,450
+error remains the same through the range or
+
+250
+00:20:43,450 --> 00:20:47,520
+concentration of the material being measuredهو
+
+251
+00:20:47,520 --> 00:20:54,140
+الخطأ الذي يبقى ثابت مهما زاد تركيز الـ Analyte
+
+252
+00:20:54,140 --> 00:20:58,620
+جواه العينة يعني مهما اختلف مستوى السكر جواه
+
+253
+00:20:58,620 --> 00:21:04,560
+العينة بيظل هذا الخطأ الثابت له نسبة معينة مثلا
+
+254
+00:21:04,560 --> 00:21:12,150
+بحكيلك نسبة الخطأ لفحص السكر مثلا 10% خلاصبتظلها
+
+255
+00:21:12,150 --> 00:21:16,990
+الـ 10% هذه ثابتة هذا بيسموه constant error مهما
+
+256
+00:21:16,990 --> 00:21:21,830
+ذات تركيز السكر فيه العينة والرسمة التانية اللي هي
+
+257
+00:21:21,830 --> 00:21:25,350
+بتمثل الـ constant error
+
+258
+00:21:27,760 --> 00:21:31,520
+أما بالنسبة لـ Random Errors الأخطاء العشوائية
+
+259
+00:21:31,520 --> 00:21:35,420
+اشتعاريفها Errors are mistakes that occur without
+
+260
+00:21:35,420 --> 00:21:39,520
+prediction or regularity هي الأخطاء اللي بتصير من
+
+261
+00:21:39,520 --> 00:21:46,200
+غير أي تنبؤ أو انتظام يعني lab technician أخصاء
+
+262
+00:21:46,200 --> 00:21:51,240
+التحليل ما بتنبأ بالخطأ إنما يحدث الخطأ فجأة بشكل
+
+263
+00:21:51,240 --> 00:21:56,910
+عشوائيmanifest themselves by variations in the
+
+264
+00:21:56,910 --> 00:22:01,410
+results of repeated analyses of the same sample
+
+265
+00:22:01,410 --> 00:22:05,210
+either positive or negative errors are usually
+
+266
+00:22:05,210 --> 00:22:08,770
+distributed أيضًا هنا بيحكيلي بقدر أكشف الـ Random
+
+267
+00:22:08,770 --> 00:22:12,870
+error من خلال التحليل المستمر بجيب عينة control
+
+268
+00:22:12,870 --> 00:22:16,870
+وبفحصلها مستوى السكر بعد ساعة كمان وبعد ساعتين
+
+269
+00:22:16,870 --> 00:22:21,510
+مثلًا اشتغلت الفحث عشر مرات يفترض العشر نتائج تكون
+
+270
+00:22:21,510 --> 00:22:26,960
+متقاربةلكن لو طلعت 9 نتائج متقاربة ونتيجة واحدة هي
+
+271
+00:22:26,960 --> 00:22:30,720
+اللي فيها المشكلة فقط نتيجة واحدة بحكي أكيد هذا
+
+272
+00:22:30,720 --> 00:22:36,220
+خطأ random عشوائي فجأة حدث عندي خلل أدى إلى حدوث
+
+273
+00:22:36,220 --> 00:22:42,120
+تغير في هذه النتيجة إذا لو حدث عندي مشكلة بنتيجة
+
+274
+00:22:42,120 --> 00:22:47,640
+واحدة فقطأنا بحكي هنا في random error لكن نتيجتين
+
+275
+00:22:47,640 --> 00:22:53,340
+حدث فيهم خلل أو أكتر هذا systematic error these
+
+276
+00:22:53,340 --> 00:22:57,140
+variations may be caused by several variable
+
+277
+00:22:57,140 --> 00:23:01,220
+factors which include هنا في هذه العبارة بيحكي ليه
+
+278
+00:23:01,220 --> 00:23:06,020
+بكل بساطة أسباب ال random error ليش بيصير الخطأ
+
+279
+00:23:06,020 --> 00:23:12,460
+العشوائي أسبابهvariations in apparatus حدوث تذبذب
+
+280
+00:23:12,460 --> 00:23:16,440
+في شغل الـ apparatus اللي هي الأجهزة يقصد فيها
+
+281
+00:23:16,440 --> 00:23:21,460
+الأجهزة في المختبر مثلا عندنا جهاز الكيميا هذا
+
+282
+00:23:21,460 --> 00:23:25,540
+الجهاز بيعمل كل الفحوصات بدل ما نشتغلها يدويًا
+
+283
+00:23:25,540 --> 00:23:29,740
+manual بيشتغلها automated بيشتغل السكر البروتينات
+
+284
+00:23:29,740 --> 00:23:34,820
+الإنزيمات وكل حاجة هذا الجهاز من جوا فكرة عملهمثل
+
+285
+00:23:34,820 --> 00:23:39,760
+فكرة عمل لـ Spectrophotometer جواته فيه لمبة، هذه
+
+286
+00:23:39,760 --> 00:23:44,000
+اللمبة بتطلع ضوء، هذا الضوء بيروح بيدرب في العينة
+
+287
+00:23:44,000 --> 00:23:49,320
+تبعتنا، بخترق العينة وبيبدأ الانتصاص والجهاز
+
+288
+00:23:49,320 --> 00:23:54,940
+بيقرألي Absorbance، تمام؟لكن لو لفجأة حدث عندي
+
+289
+00:23:54,940 --> 00:23:59,580
+تذبذب في الجهاز يعني تذبذب في الطيار الكهربائي
+
+290
+00:23:59,580 --> 00:24:02,760
+اللي مشبوك فيه الجهاز الجهاز مشبوك على الكهربا
+
+291
+00:24:02,760 --> 00:24:09,100
+لفجأة ممكن الطيار الكهربائي يضعف لما بيدعف الشعاع
+
+292
+00:24:09,100 --> 00:24:13,050
+اللي بيطلع من اللمبة بيكون كتير ضعيفوحتى لو ضرب
+
+293
+00:24:13,050 --> 00:24:18,050
+بيه العينة تبعتي مش هيعطيني القراءة الصحيحة
+
+294
+00:24:18,050 --> 00:24:22,470
+وبالتالي النتيجة هتكون خاطئة إذا الطيار الكهربائي
+
+295
+00:24:22,470 --> 00:24:26,910
+لما بيدعف، بيدعف للحظة وبرجعي جوا عشان هيك هتلاحظ
+
+296
+00:24:26,910 --> 00:24:31,690
+لو عملتي فحص السكر لعشر مرات لعينة ال control في
+
+297
+00:24:31,690 --> 00:24:35,900
+كل المرات طلعت النتائج صحيحة ما عدا مرةهذا random
+
+298
+00:24:35,900 --> 00:24:41,180
+error بحكي ممكن ضعفت الكهربا على الجهاز فخلال ما
+
+299
+00:24:41,180 --> 00:24:45,580
+ضعفت أعطاني نتيجة خاطئة تمام أو variation في ال
+
+300
+00:24:45,580 --> 00:24:49,940
+temperature مثلا درجات الحرارة، ظروف التفاعل لو
+
+301
+00:24:49,940 --> 00:24:54,100
+اختلفت للحظة مثلا درجة الحرارة تحت الغرفة يفترض
+
+302
+00:24:54,100 --> 00:25:01,740
+تكون 22 ل 25 عليةوتيط هذا كله بيأثر على الفحوصات
+
+303
+00:25:01,740 --> 00:25:07,620
+اللي احنا بنشتغلها الـ weighting اللي هو الميزان
+
+304
+00:25:07,620 --> 00:25:13,380
+اللي بنستخدمه مثلا لوزن بعض الشغلات برضه في أجهزة
+
+305
+00:25:13,380 --> 00:25:17,740
+بتكون على الكهربا برضه مشكلة أو تذبذب في الكهربا
+
+306
+00:25:17,740 --> 00:25:21,460
+هيعمل عندنا مشكلة ويعطينا نتائج خاطئة الـ Random
+
+307
+00:25:21,460 --> 00:25:24,830
+error cannot be avoided للأسفالأخطاء العشوائية ما
+
+308
+00:25:24,830 --> 00:25:29,410
+بقدر أتجنبها يعني أنا بحاول أقلل منها بس دايما
+
+309
+00:25:29,410 --> 00:25:33,290
+اتجيني فجأة خلاف الـ Systematic Errors Systematic
+
+310
+00:25:33,290 --> 00:25:37,610
+Error بقدر يعني avoided يعني بقدر أني أتجنبها
+
+311
+00:25:37,610 --> 00:25:42,150
+these random errors can be reduced أنا ممكن أقلل
+
+312
+00:25:42,150 --> 00:25:46,460
+من حدوث الـ Random Errorby more precise method and
+
+313
+00:25:46,460 --> 00:25:51,340
+more accurate equipment إن أختار معدات وأجهزة وطرق
+
+314
+00:25:51,340 --> 00:25:56,310
+تحليل تكون صحيحة ودقيقةهنا بدنا نحكي عن الـ method
+
+315
+00:25:56,310 --> 00:26:00,650
+validation التأكد من صحة الطريقة المستخدمة في
+
+316
+00:26:00,650 --> 00:26:06,770
+التحليل أو تقييم الطريقة أو تقييم الـ kit الجديد
+
+317
+00:26:06,770 --> 00:26:11,770
+اللي بدنا نشتريه من الشركة المصنعة أنا كمختبر خاص
+
+318
+00:26:11,770 --> 00:26:17,050
+بشتغل مثلا فحص السكر بدي كتات للسكر كت السكر عبارة
+
+319
+00:26:17,050 --> 00:26:21,330
+عن شو؟ بكون فيه الـ reagent الـ standard الخاص
+
+320
+00:26:21,330 --> 00:26:25,940
+بالسكرهذا من وين، مين بيصنعه؟ بتصنعه الشركة عادة
+
+321
+00:26:25,940 --> 00:26:30,160
+أنا لما أروح أجيب هذا الـKit غلط أجيبه من الشركة
+
+322
+00:26:30,160 --> 00:26:34,600
+وبسرعة أروح أستخدمه وأعمل فيه فحوصات وأطلع نتائج
+
+323
+00:26:34,600 --> 00:26:41,260
+لناس يجب قبل استخدام الـKit أشيك على خمس شغلات في
+
+324
+00:26:41,260 --> 00:26:45,340
+الـKit، بدي أشيك على الـAccuracyالصحة وعلى
+
+325
+00:26:45,340 --> 00:26:49,000
+الـPrecision الدقة وعلى الـSensitivity الحساسية
+
+326
+00:26:49,000 --> 00:26:53,640
+وعلى الـSpecificity التخصصية وعلى الـLinearity
+
+327
+00:26:53,640 --> 00:26:58,440
+الخطية يعني خمس شغلات بتاخدها بعين الاعتبار عند
+
+328
+00:26:58,440 --> 00:27:03,620
+شراء أي كت جديد لأي فحص أول إشي الـAccuracy
+
+329
+00:27:03,620 --> 00:27:08,260
+الصحةThe measure of correctness or truth of
+
+330
+00:27:08,260 --> 00:27:15,300
+laboratory test هي عبارة عنقياس القيمة الحقيقية
+
+331
+00:27:15,300 --> 00:27:21,360
+للفحص هذه الـ accuracy الصحة يعني .. يعني جداش انت
+
+332
+00:27:21,360 --> 00:27:25,380
+.. يعني جداش هذا الـ kit بيعطيني و هذا الـ reagent
+
+333
+00:27:25,380 --> 00:27:29,080
+و المواد تعطيني نتيجة صحيحة يعني لو أنا استخدمت
+
+334
+00:27:29,080 --> 00:27:33,420
+الـ kit و استخدمت الـ reagent تبع السكر جداش هذا
+
+335
+00:27:33,420 --> 00:27:38,660
+الـ reagent بيعطيني صحة في النتائجهذا معنى الـ
+
+336
+00:27:38,660 --> 00:27:45,900
+Accuracy هي عبارة عن قياس القيمة الحقيقية للفحص زي
+
+337
+00:27:45,900 --> 00:27:52,700
+ما احنا شايفين وين جاي السهم؟ جاي السهم Target لو
+
+338
+00:27:52,700 --> 00:27:58,890
+كان الـ Kit تبعنابقيص مستوى السكر target معناه هذا
+
+339
+00:27:58,890 --> 00:28:02,630
+المطلوب معناه هذا الـ kick ممتاز هذا الـ reagent
+
+340
+00:28:02,630 --> 00:28:08,390
+100% كويس لأنه بيجيس ليه القيمة target بقطين
+
+341
+00:28:08,390 --> 00:28:13,950
+القيمة الحقيقيةتمام الـ Accuracy إلها تعريف آخر مش
+
+342
+00:28:13,950 --> 00:28:18,670
+موجود عندنا هتاخدوه بالنظر مع الدكتور مازن هو
+
+343
+00:28:18,670 --> 00:28:25,270
+عبارة عن مدى قرب القيمة المقاسة من القيمة الحقيقية
+
+344
+00:28:25,810 --> 00:28:29,290
+القيمة المقاسة اللي أنا جستها بالـ KET القيمة
+
+345
+00:28:29,290 --> 00:28:34,530
+الحقيقية هي القيمة اللي أصلا شركة مثلا لما بتجيبلك
+
+346
+00:28:34,530 --> 00:28:38,130
+Control تعطيك الـ Normal Range للسكر تبعه فالجيت
+
+347
+00:28:38,130 --> 00:28:41,890
+لو أنا استخدمت الـ Control هذا وجستله السكر بالـ
+
+348
+00:28:41,890 --> 00:28:47,730
+KET وطلع نتيجةالنتيجة اللي أنا طلعتها دي قيمة
+
+349
+00:28:47,730 --> 00:28:52,890
+مقاسة فمدى قرب القيمة المقاسة اللي أنا طلعتها من
+
+350
+00:28:52,890 --> 00:28:57,190
+القيمة الحقيقية اللي طلعتها الشركة هذا بنسميه الـ
+
+351
+00:28:57,190 --> 00:29:00,170
+Accuracy يعني لو كانت القيمة اللي أنا جيستها سبعين
+
+352
+00:29:00,170 --> 00:29:04,870
+وقيمة الشركة اللي طلعتها الشركة سبعين اتنين وسبعين
+
+353
+00:29:04,870 --> 00:29:09,540
+معناها هذا الـ kit ممتاز انه بطلع نتائج كويسةالـ
+
+354
+00:29:09,540 --> 00:29:14,100
+Precision اللي هي مدى الإحكام الـ Agreement
+
+355
+00:29:14,100 --> 00:29:19,120
+between replicate measurement مدى التوافق بين
+
+356
+00:29:19,120 --> 00:29:24,360
+النتائج اللي طلعت نتيجة الـ replication إعادة
+
+357
+00:29:24,360 --> 00:29:29,280
+الفحص هنا مفهوم الـ Precision حكيتلكم إيه الـ Jeep
+
+358
+00:29:29,280 --> 00:29:34,490
+Controlهذا الـ Control أعمله فحص السكر أكتر من مرة
+
+359
+00:29:34,490 --> 00:29:40,710
+عشر مرات مدى قرب النتائج من بعضها البعض هذا بنسمي
+
+360
+00:29:40,710 --> 00:29:44,990
+precision والله هذا ال kit more precise أنا جبت كت
+
+361
+00:29:44,990 --> 00:29:50,290
+جديد وجبت عينة وحلمت هذه العينة بهذا ال kit عشر
+
+362
+00:29:50,290 --> 00:29:54,250
+مرات والنتائج مثلا عملت فحص السكر النتائج كانت
+
+363
+00:29:54,250 --> 00:29:58,930
+كلها متقاربة من بعض تقارب النتائج من بعض هذا بنسمي
+
+364
+00:29:58,930 --> 00:30:04,100
+precisionالتقارب، الإحكام أو بيسموه الـ
+
+365
+00:30:04,100 --> 00:30:06,940
+Reproducibility معناه إنت إيش يعني
+
+366
+00:30:06,940 --> 00:30:11,080
+Reproducibility؟ لما تعمل إعادة للفحص أكتر من مرة
+
+367
+00:30:11,080 --> 00:30:16,260
+هتلاقي النتائج هي نفسها متقاربة هي عندنا أكتر من
+
+368
+00:30:16,260 --> 00:30:20,560
+سهم، عملت الفحص أكتر من مرة يعني عندي أكتر من سهم
+
+369
+00:30:20,560 --> 00:30:24,720
+وكل الأسهم زي ما إحنا شايفين متقاربة معناه فيه
+
+370
+00:30:24,720 --> 00:30:30,680
+precision عالي، عندنا إحكام عاليلو إيجينا للرسمة
+
+371
+00:30:30,680 --> 00:30:33,880
+اللي أمامنا خلينا نتطلع في الرسمتين اللي فوق
+
+372
+00:30:33,880 --> 00:30:39,060
+بالأول الرسمة اللي على اليمين هتلاحظ نقطة ثمرة
+
+373
+00:30:39,060 --> 00:30:42,620
+كبيرة بالنص هذه النقطة الثمرة الكبيرة بالنص بتعبر
+
+374
+00:30:42,620 --> 00:30:49,300
+أنه أنا كانت عندي عينة وجبت كت السكر واشتغلت هذه
+
+375
+00:30:49,300 --> 00:30:54,660
+العينة أكتر من مرةفحص السكر وطلع عندى مجموعة نتائج
+
+376
+00:30:54,660 --> 00:31:00,500
+هذه النتائج كلها متراكمة وكلها جانب بعض اتكومت
+
+377
+00:31:00,500 --> 00:31:06,020
+وانحطت بالنص معناه هذا الـ kit عنده high precision
+
+378
+00:31:06,020 --> 00:31:10,100
+ايش يعني high precision ان النتائج متقاربة كتير من
+
+379
+00:31:10,100 --> 00:31:13,560
+بعض لو انت عدت الفحص اكتر من مرة النتائج متقاربة
+
+380
+00:31:13,560 --> 00:31:18,900
+وhigh accuracy يعني عندى صحة كل النتائج اجت بالنص
+
+381
+00:31:18,900 --> 00:31:24,630
+اجت target تمام؟أما الرسم اللي فوق اللي على اليسار
+
+382
+00:31:24,630 --> 00:31:29,650
+لو لاحظتي أنه عندي مجموعة نتائج متكومة تمام نقطة
+
+383
+00:31:29,650 --> 00:31:35,030
+سمرة متكومة ومحتوطين تمام بيحكيلك high precision
+
+384
+00:31:35,030 --> 00:31:39,410
+okay نتائج متقاربة من بعضها البعد معناه في عندي
+
+385
+00:31:39,410 --> 00:31:45,150
+precision لكن لا accuracy هذا الكت مافي صح ليش؟
+
+386
+00:31:45,150 --> 00:31:50,600
+لأنه النتائج ماوجعت في ال targetالـ Target عنده
+
+387
+00:31:50,600 --> 00:31:56,120
+بالنص أو الدائرة الحمرا هذه target لكن تجعب برا لأ
+
+388
+00:31:56,120 --> 00:32:02,180
+بتكون فقدت الصحة تعالوا نشوف اليسار تحت الرسمتين
+
+389
+00:32:02,180 --> 00:32:04,080
+اللي على اليسار تحت
+
+390
+00:32:08,030 --> 00:32:14,110
+الرسمتين اللي تحت، جهة اليمين، بتلاحظ فيه نتائج
+
+391
+00:32:14,110 --> 00:32:18,790
+متفرقة عن بعضها البعض، مش متكومة مع بعضها البعض،
+
+392
+00:32:18,790 --> 00:32:23,290
+النتائج متفرقة، معناه مافي precision، مافي توافق
+
+393
+00:32:23,290 --> 00:32:29,050
+بينها، مافي تقاربلكن فيه high accuracy في صحة يعني
+
+394
+00:32:29,050 --> 00:32:33,510
+في صحة معناها okay جربت من ال target okay مش جوة
+
+395
+00:32:33,510 --> 00:32:38,050
+في المتصف الدائرة البيضة لجوة okay لكن جريبة شويه
+
+396
+00:32:38,050 --> 00:32:43,850
+من ال targetأما الرسمة اللي تحت على الآخر جهة
+
+397
+00:32:43,850 --> 00:32:49,930
+اليسار بيحكيلي لو انتوا لاحظتوا النقاط نقاط متبعدة
+
+398
+00:32:49,930 --> 00:32:54,030
+جدا يعني low precision مافي تقارب أيضا low
+
+399
+00:32:54,030 --> 00:32:58,930
+accuracy برضه مافي صحة لأنها بعيدة جدا عن الهدف
+
+400
+00:32:58,930 --> 00:33:06,160
+وعن الدائرة اللي في المنتصفخلّصنا من الـ accuracy
+
+401
+00:33:06,160 --> 00:33:08,460
+و الـ precision خلّينا نشوف الـ sensitivity
+
+402
+00:33:08,460 --> 00:33:13,040
+الحساسية كلنا عارفين إيش يعني حساسية الـ kit the
+
+403
+00:33:13,040 --> 00:33:16,300
+ability of a diagnostic test to detect very small
+
+404
+00:33:16,300 --> 00:33:21,140
+amounts of the analyte قدرة الفحص أو الـ kit إنه
+
+405
+00:33:21,140 --> 00:33:26,140
+يكشف ليه عن أقل كمية من الـ analyte موجودة بالعينة
+
+406
+00:33:26,140 --> 00:33:30,460
+هذا التعريف كلنا عارفينه في تعريف آخر برضه أنتوا
+
+407
+00:33:30,460 --> 00:33:34,690
+عارفينه أخدته في الإحصاءالحساسية هي عبارة عن
+
+408
+00:33:34,690 --> 00:33:39,230
+ability to correctly identify الـ individual with
+
+409
+00:33:39,230 --> 00:33:45,570
+disease قدرة الـ kit إنه يميزلي ويكشفلي عن الأشخاص
+
+410
+00:33:45,570 --> 00:33:52,050
+المصابين بالمرض أيضًا تعريف آخر لـ sensitivity هي
+
+411
+00:33:52,050 --> 00:33:57,230
+ال ability to exclude الـ false negative قدرة الـ
+
+412
+00:33:57,230 --> 00:34:03,910
+kit إنه يكشفلي أو إنه يستثنيلي الأشخاصاللي هما
+
+413
+00:34:03,910 --> 00:34:08,350
+Exclude يستثنى الأشخاص الـ False Negative يعني
+
+414
+00:34:08,350 --> 00:34:16,130
+اللي هما أصلا حقيقة عندهم المرض لكن لسبب ما طلعت
+
+415
+00:34:16,130 --> 00:34:19,670
+نتيجتهم False Negative اللي هو الـ Negative الكاذب
+
+416
+00:34:19,670 --> 00:34:26,220
+إذا قانون الـ Sensitivity أخدناه كلنا بالإحصاءالـ
+
+417
+00:34:26,220 --> 00:34:30,160
+number of true positive على الـ number of true
+
+418
+00:34:30,160 --> 00:34:34,960
+positive زائد الـ number of false negative true
+
+419
+00:34:34,960 --> 00:34:39,800
+positive على true positive زائد false negative هذا
+
+420
+00:34:39,800 --> 00:34:44,860
+القانون اللي مطلوب معناه أما لـ specificity
+
+421
+00:34:44,860 --> 00:34:49,820
+التخصصية هي عبارة عن detect the desired analyte
+
+422
+00:34:49,820 --> 00:34:56,050
+without interferences قدرة الـ CATأو الفحص إنه
+
+423
+00:34:56,050 --> 00:35:01,210
+يتفاعل مع الـ Analyte المطلوب قياسها من غير ما
+
+424
+00:35:01,210 --> 00:35:06,290
+يتفاعل مع Analyte أخرى أنا ما بدي أقيسها مثلا أنا
+
+425
+00:35:06,290 --> 00:35:10,870
+كت السكر يفترض الـ Reagent تبع السكر المستخدم في
+
+426
+00:35:10,870 --> 00:35:16,810
+الفحص يتفعلي فقط مع السكر الموجود بعينة المريض
+
+427
+00:35:16,950 --> 00:35:21,170
+وممنوع يتفاعل مع أي analyte أخرى، مع أي مادة أخرى،
+
+428
+00:35:21,170 --> 00:35:23,770
+ممنوع يتفاعل مع الـ Total Protein، ممنوع يتفاعل مع
+
+429
+00:35:23,770 --> 00:35:29,430
+أنزماء، تمام؟أو تعريف آخر الـ ability to correctly
+
+430
+00:35:29,430 --> 00:35:33,850
+identify individual without disease قدرة الفحص أنه
+
+431
+00:35:33,850 --> 00:35:38,870
+يميزلي الناس اللي ما بتعاني من أمراض اللي هم ال
+
+432
+00:35:38,870 --> 00:35:43,390
+true negative اللي عن جد أصحى أو تعريف آخر ال
+
+433
+00:35:43,390 --> 00:35:46,870
+ability to occlude ال false positive قدرة الفحص
+
+434
+00:35:46,870 --> 00:35:51,990
+أنه يستفنى الناس ال false positive اللي هم أصلا ما
+
+435
+00:35:51,990 --> 00:35:58,220
+عندهم حقيقة ما عندهم المرض لكن لسببما الفحص طلّع
+
+436
+00:35:58,220 --> 00:36:03,320
+نتيجتهم إن عندهم المرض بشكل كاذب إذن قانون
+
+437
+00:36:03,320 --> 00:36:08,240
+specificity عدد الأشخاص الأصحاء الـ number of true
+
+438
+00:36:08,240 --> 00:36:11,540
+negative على الـ number of true negative زائد الـ
+
+439
+00:36:11,540 --> 00:36:15,850
+number of false positiveهذا الجدول اللي أخدناه
+
+440
+00:36:15,850 --> 00:36:18,690
+بالإحصاء أهم إشي بس بدنا نعرف قانوني الـ
+
+441
+00:36:18,690 --> 00:36:22,050
+sensitivity و ال specificity ال sensitivity true
+
+442
+00:36:22,050 --> 00:36:26,170
+positive تحت على ال true positive زائد false
+
+443
+00:36:26,170 --> 00:36:30,030
+negative أما ال specificity هو عبارة عن ال true
+
+444
+00:36:30,030 --> 00:36:33,970
+negative على ال true negative زائد false positive
+
+445
+00:36:34,950 --> 00:36:39,210
+الـ Linearity الخطية عبارة عن is the range over
+
+446
+00:36:39,210 --> 00:36:42,990
+which the analytical system exhibits a linear هو
+
+447
+00:36:42,990 --> 00:36:48,890
+النطاق الذي يظهر فيه النظام التحليلي خطيابمعنى
+
+448
+00:36:48,890 --> 00:36:54,770
+يعني بمعنى أبسط من هيك وكلنا عارفينه إن الخطية و
+
+449
+00:36:54,770 --> 00:36:59,430
+الـ linearity تبعت أي كت هو أعلى قيمة وأقل قيمة
+
+450
+00:36:59,430 --> 00:37:04,030
+يستطيع الـ kit قياسهم، إذا أعلى قيمة وأقل قيمة
+
+451
+00:37:04,030 --> 00:37:07,490
+يستطيع الـ kit قياسهم هذه الـ linearity، the
+
+452
+00:37:07,490 --> 00:37:12,100
+highest concentration can be detected، تمام؟يعني
+
+453
+00:37:12,100 --> 00:37:16,460
+مثلًا كل Kit له Linearity معينة مثلًا السكر بكتب
+
+454
+00:37:16,460 --> 00:37:21,220
+لك في ال pamphlet تبعته في الورقة أن هذا الـKit
+
+455
+00:37:21,220 --> 00:37:27,720
+بقدر يجيس السكر من 46 إلى 600 لو إجاني شخصسكره
+
+456
+00:37:27,720 --> 00:37:34,720
+أعلى من 600 أو أقل من 46 مش هيقدر هذا الـ Reagent
+
+457
+00:37:34,720 --> 00:37:39,420
+يتفاعل مع السكر اللي موجود بعينته ومش هيعطيني أي
+
+458
+00:37:39,420 --> 00:37:43,740
+نتيجة هذه فكرة الـ Linearity مين بيقيصها، بتقيصها
+
+459
+00:37:43,740 --> 00:37:49,120
+الشركةThe measured value from a series of samples
+
+460
+00:37:49,120 --> 00:37:53,820
+solution is linearly proportional to the actual
+
+461
+00:37:53,820 --> 00:37:58,120
+concentration or content of the analyte in the
+
+462
+00:37:58,120 --> 00:38:03,660
+sample solution هذا الكلام يعني هو شغل شركات أكتر
+
+463
+00:38:03,660 --> 00:38:09,160
+من أنه يعني احنا لازم نهتم فيهعند الرسم اللي فوق
+
+464
+00:38:09,160 --> 00:38:17,020
+هي شكل Linear هذا بتكون X-axis وY-axis على الـ X
+
+465
+00:38:17,020 --> 00:38:21,860
+-axis تحت بحطوا الـ actual concentration التركيز
+
+466
+00:38:21,860 --> 00:38:26,220
+اللي من الشركة وعلى ال Y-axis بحطوا الـ measured
+
+467
+00:38:26,220 --> 00:38:30,820
+value القيم اللي أنا guessedها و الشركة بتمثل
+
+468
+00:38:30,820 --> 00:38:34,920
+العلاقة وهي اللي بتحسب الخطيئة فقط هذا اللي بدنا
+
+469
+00:38:34,920 --> 00:38:40,250
+نفهمهبدنا نفرق بين الـ Control و الـ Standard و
+
+470
+00:38:40,250 --> 00:38:43,870
+الـ Calibrator لإن كتير في ناس بتخلط بينهم الـ
+
+471
+00:38:43,870 --> 00:38:48,950
+Control هو عبارة عن محلول بيجينا من الشركة إما
+
+472
+00:38:48,950 --> 00:38:54,430
+Powder أو Liquid وعبارة عن solution محلول يحتوي
+
+473
+00:38:54,430 --> 00:39:01,000
+على نفس مكونات عينة المريضأصلا الـ control من وين
+
+474
+00:39:01,000 --> 00:39:05,740
+بيعملوا؟ من ناس الصحة أو من ناس مرضى، صح ولا لا،
+
+475
+00:39:05,740 --> 00:39:10,080
+سواء بيعملوا normal control أو abnormal control،
+
+476
+00:39:10,080 --> 00:39:14,740
+إذا مكونات الـ control هي نفس مكونات الدم تبع ال
+
+477
+00:39:14,740 --> 00:39:18,800
+patient، تبع المريض، نفس المكونات، a solution that
+
+478
+00:39:18,800 --> 00:39:24,680
+containsthe same constituent نفس المكونات as those
+
+479
+00:39:24,680 --> 00:39:28,400
+being analyzed in the patient sample وعادة بيجيني
+
+480
+00:39:28,400 --> 00:39:31,780
+مع الشركة وبتيجي معاها ورقة هذه الورقة فيها
+
+481
+00:39:31,780 --> 00:39:36,160
+الـnormal range مثلا السكر من 70 ل110 milligram
+
+482
+00:39:36,160 --> 00:39:41,920
+per deciliter فيه range للانالايت
+
+483
+00:39:41,920 --> 00:39:47,520
+اللي أنا بدي أجيسها أما الـstandardعبارة عن
+
+484
+00:39:47,520 --> 00:39:51,620
+substance of constant composition and of
+
+485
+00:39:51,620 --> 00:39:55,000
+sufficient purity to be used for comparison
+
+486
+00:39:55,000 --> 00:40:01,570
+purposeالـ Standard عبارة عن محلول يحتوي على مادة
+
+487
+00:40:01,570 --> 00:40:06,810
+واحدة substance واحدة، مادة واحدة هذه المادة لها
+
+488
+00:40:06,810 --> 00:40:10,850
+constant composition يعني لها exact concentration
+
+489
+00:40:10,850 --> 00:40:16,690
+لها تركيز معين مثلًا، الـ Kit تبع السكر بيجي مع
+
+490
+00:40:16,690 --> 00:40:21,410
+الـ Standard هذا الـ Standard جوا محلول جواة السكر
+
+491
+00:40:22,300 --> 00:40:27,220
+بيكون موجود جوات السكر وهذا السكر بيكون له تركيز
+
+492
+00:40:27,220 --> 00:40:36,340
+معين ويستخدم الـ Standard من أجل معرفة تركيز عينة
+
+493
+00:40:36,340 --> 00:40:40,620
+unknown عينة مجهولة، هذا اشتغلته في سنة تانية لما
+
+494
+00:40:40,620 --> 00:40:44,840
+عملته فحص السكركان عندكوا استخدمتوا standard السكر
+
+495
+00:40:44,840 --> 00:40:51,180
+لما بتستخدمي انت ال standard بتعرفي تركيز عينة ال
+
+496
+00:40:51,180 --> 00:40:56,290
+patient اللي هي ال unknown هذا الهدف منهمن خلال
+
+497
+00:40:56,290 --> 00:41:03,350
+معرفة تركيز الـ Standard بقدر أعرف تركيز السكر
+
+498
+00:41:03,350 --> 00:41:07,010
+اللي موجود في عينات الـ Patient طبعا الـ Standard
+
+499
+00:41:07,010 --> 00:41:11,190
+لأنه بيحتوي على مادة واحدة فالـ Purity تبعته
+
+500
+00:41:11,190 --> 00:41:15,080
+عالية، نقاطه عاليةأما الـCalibrator، Similar to
+
+501
+00:41:15,080 --> 00:41:20,040
+Standard هو نفس الـStandard بالظبط، لكن مش Pure،
+
+502
+00:41:20,040 --> 00:41:23,840
+مش نقي لأن الـCalibrator عادة بتكون من Multiple
+
+503
+00:41:23,840 --> 00:41:29,160
+Substance من أكتر من مادة الـCalibrator بتكون من
+
+504
+00:41:29,160 --> 00:41:32,820
+أكتر من مادة مع بعض، solution بيحتوي على أكتر من
+
+505
+00:41:32,820 --> 00:41:37,940
+مادة وكل مادة إلها Exact Concentration، إلها تركيز
+
+506
+00:41:37,940 --> 00:41:44,520
+معينالـ Interpretation of Quality Control Charts
+
+507
+00:41:44,520 --> 00:41:49,960
+طبعاً بدنا نحكي معلومة أنه أنا مثلا كمختبر أو
+
+508
+00:41:49,960 --> 00:41:55,980
+كمستشفى كل يوم قبل ما أشبك عينات المرضى على الجهاز
+
+509
+00:41:55,980 --> 00:42:01,680
+لازم أشتغل control أجيب عينات control أعملها فحص
+
+510
+00:42:01,680 --> 00:42:06,040
+السكر وفحص البروتين وكل الفحصات أطلبلها كل الفحصات
+
+511
+00:42:06,040 --> 00:42:11,910
+على الجهازوأشتغلها وأطلّع نتائجها وأشوف كيف نتائج
+
+512
+00:42:11,910 --> 00:42:15,850
+الـ Control بعد ما أتأكد إن نتائج الـ Control كلها
+
+513
+00:42:15,850 --> 00:42:21,610
+سليمة وصحيحة وبعطيني نتائج تمام بروح بقشبك عينات
+
+514
+00:42:21,610 --> 00:42:26,990
+المرضى على الجهاز وأنا مضطنة هلجيت نتائج الـ
+
+515
+00:42:26,990 --> 00:42:31,930
+Control اللي بتطلع هذه إحنا لازم نمثلها على الـ
+
+516
+00:42:31,930 --> 00:42:36,260
+Chart نمثلها على رسمةعشان أنا بدي أعمل
+
+517
+00:42:36,260 --> 00:42:40,660
+Interpretation بدي أعمل تحليل لنتائج ال control
+
+518
+00:42:40,660 --> 00:42:46,660
+اللي أنا بشبكها كل يوم لأن هذا واجب واجب ومطلوب
+
+519
+00:42:46,660 --> 00:42:50,320
+منها لأن مثلا وزارة الصحة تتيجي حملة تفتيش على
+
+520
+00:42:50,320 --> 00:42:56,580
+المختبر كل شهر كل شهر بتبقى ترسميه chart ترسميه
+
+521
+00:42:56,580 --> 00:43:01,770
+شكل تمثل فيه نتائج ال control اللي طلعت معكعلى
+
+522
+00:43:01,770 --> 00:43:06,350
+مدار الشهر مش احنا اتفجنا كل يوم بدك تشبك control
+
+523
+00:43:06,350 --> 00:43:11,250
+وتشتغلي عينة ال control جبل ما تبدأ تشتغلي عينة ال
+
+524
+00:43:11,250 --> 00:43:16,790
+patient على مدار التلاتين يوم بعد ما تخلصي اليوم
+
+525
+00:43:16,790 --> 00:43:21,880
+الأخر يوملما تخلصي بتجمعي نتائج الـ Control مثلا
+
+526
+00:43:21,880 --> 00:43:26,500
+لفحص السكر وبتروح ترسميها على منحنى هذا المنحنى
+
+527
+00:43:26,500 --> 00:43:31,980
+اسمه «Levy-Jones Control Chart» بخص نتائج الـ
+
+528
+00:43:31,980 --> 00:43:35,500
+Control وهذا المنحنى هو الـ most widely used
+
+529
+00:43:35,500 --> 00:43:39,680
+technique هو الأكثر انتشارا واستخداما لعنا منحنيات
+
+530
+00:43:39,680 --> 00:43:44,380
+أخرى بس هو الأكتر استخداما الكلام اللي تحت محكيه
+
+531
+00:43:44,380 --> 00:43:49,530
+هذا احنا هنحكيه على الرسمة بالـ Slider التانيةهذا
+
+532
+00:43:49,530 --> 00:43:53,630
+اللي أمامنا هو الـ Levigenance Chart هذا الـ Chart
+
+533
+00:43:53,630 --> 00:43:59,990
+المنحنة وهذه النتائج هي نتائج لفحص السكر على مدار
+
+534
+00:43:59,990 --> 00:44:06,550
+20 يوم على الـ X-axis هذا المنحنة لازم أحط الأيام
+
+535
+00:44:06,550 --> 00:44:10,870
+اليوم الأول، اليوم التاني، تلاتة، أربعة، خمسة،
+
+536
+00:44:10,870 --> 00:44:15,890
+ستة، لحد اليوم العشرينعلى الـ Y Axis في المنتصف
+
+537
+00:44:15,890 --> 00:44:20,150
+باجي وبحط الـ Meme الـ Meme هو الـ X Bar الوسط
+
+538
+00:44:20,150 --> 00:44:25,290
+الحسابي الوسط الحسابي قانونه مجموع القيم على عددها
+
+539
+00:44:25,290 --> 00:44:30,930
+أي قيم، قيم السكراللي طلعتها خلال عشرين يوم مش
+
+540
+00:44:30,930 --> 00:44:34,790
+اتفقنا في أول يوم في اليوم الأول شبكت ال control
+
+541
+00:44:34,790 --> 00:44:39,990
+وطلعت نتيجة السكر له بسجلها في اليوم التاني بشتغل
+
+542
+00:44:39,990 --> 00:44:44,350
+ال control برضه و بسجل نتيجة السكر له في اليوم
+
+543
+00:44:44,350 --> 00:44:48,790
+التالت برضه بشتغل ال control و بشتغله فحص السكر و
+
+544
+00:44:48,790 --> 00:44:55,570
+بسجل نتيجته إذا صار عندي عشرين نتيجة للسكربروح
+
+545
+00:44:55,570 --> 00:45:00,990
+أجمع العشرين قيمة على عددهم وبطلّع الـ X bar أو ما
+
+546
+00:45:00,990 --> 00:45:05,450
+يسمى الـ mean الوسط الحسابي وهدول العشرين قيمة
+
+547
+00:45:05,450 --> 00:45:09,550
+برضه بروح أحسبلهم لـ standard deviation مقدار
+
+548
+00:45:09,550 --> 00:45:16,150
+التشططبالقانون اللي انت عارفينه بعدين بروح احسب ال
+
+549
+00:45:16,150 --> 00:45:21,610
+statistical limit الحدود اللي فوق المين واللي تحت
+
+550
+00:45:21,610 --> 00:45:28,250
+المين فوق المين ايش plus واحد هذا عبارة عن كيف
+
+551
+00:45:28,250 --> 00:45:34,560
+بحسبه بروح اجيبالـ mean زائد واحد standard
+
+552
+00:45:34,560 --> 00:45:41,120
+deviation بتجيب الوسط الحسابي و بتجمعي لواحد ضرب
+
+553
+00:45:41,120 --> 00:45:46,860
+الـ standard deviation اللي حسبتيه فوق X bar زائد
+
+554
+00:45:46,860 --> 00:45:53,330
+اتنين SDالوسط الحسابي بتجمعيه للـ Standard
+
+555
+00:45:53,330 --> 00:45:59,570
+Deviation مضروب في 2 فوق X bar زائد 3SD الوسط
+
+556
+00:45:59,570 --> 00:46:05,170
+الحسابي بتجمعيه لـ 3 مضروب في الـ Standard
+
+557
+00:46:05,170 --> 00:46:14,580
+Deviation تحت الـ Main عندي –1S –2S –3Sبرضه بتجيبي
+
+558
+00:46:14,580 --> 00:46:19,400
+الوسط الحسابي و بتطرحي من واحد standard deviation
+
+559
+00:46:19,400 --> 00:46:22,220
+واحد standard deviation كلكم عارفين واحد ضرب
+
+560
+00:46:22,220 --> 00:46:26,000
+standard deviation بعدين بتجيبي X bar الوسط
+
+561
+00:46:26,000 --> 00:46:30,200
+الحسابي بتطرحي من ال standard deviation مضروب في
+
+562
+00:46:30,200 --> 00:46:35,120
+اتنين برضه الوسط الحسابي بتطرحي من ال standard
+
+563
+00:46:35,120 --> 00:46:39,780
+deviation مضروب في تلاتة و بتجيبي الحدود ما فوق ال
+
+564
+00:46:39,780 --> 00:46:45,270
+mean و ما تحت ال meanهذا الـ Chart بنسميه الـ Levy
+
+565
+00:46:45,270 --> 00:46:50,330
+-Jones Chart وبعدين بتيجي في اليوم الأول جداش طلع
+
+566
+00:46:50,330 --> 00:46:54,890
+مستوى السكر بتمثل النقطة في اليوم التاني جداش طلع
+
+567
+00:46:54,890 --> 00:46:58,830
+مستوى السكر بتمثل النقطة زي ما هو ممثل وفي اليوم
+
+568
+00:46:58,830 --> 00:47:02,970
+التالت والرابع وهاكذا وبعد هيك بتوصلي ما بين
+
+569
+00:47:02,970 --> 00:47:09,360
+النقاط هيك أنا بكونمثلت نتائج الـ Control خلال
+
+570
+00:47:09,360 --> 00:47:15,180
+عشرين يوم لفحص السكر مثلا أو فحص Enzyme على منحنة
+
+571
+00:47:15,180 --> 00:47:20,160
+الـ Levy-Jones Chart بهاي الـ Slide بس بديوا ياكوا
+
+572
+00:47:20,160 --> 00:47:24,080
+تعرفوا كيف بنحسب الـ Mean الوسط الحسابي مجموع
+
+573
+00:47:24,080 --> 00:47:28,460
+القيم على عددها وكيف بنحسب مقدار تشطط الـ Standard
+
+574
+00:47:28,460 --> 00:47:32,080
+Deviation بالقانون اللي أخدته بالإحصاء coefficient
+
+575
+00:47:32,080 --> 00:47:37,750
+of variation ما بدنا ياههلجيت أنا بعد ما مثّلت
+
+576
+00:47:37,750 --> 00:47:41,630
+نتائج الـ Control على الـ Levy Jenins الـ Chart
+
+577
+00:47:41,630 --> 00:47:48,330
+بدي أبدأ أشوف أنا عندي عشرين يوم وعشرين نتيجة على
+
+578
+00:47:48,330 --> 00:47:53,110
+المنحنى بدي أشوف وين في نتائج فيها مشاكل وين في
+
+579
+00:47:53,110 --> 00:47:58,950
+نتائج كانت ضمن الوضع الطبيعي للـ Control هلجيت في
+
+580
+00:47:58,950 --> 00:48:04,590
+شغل اسمهاالـ Westgard Equality Control Rules قواعد
+
+581
+00:48:04,590 --> 00:48:09,570
+اسمها Westgard Rule هذه القواعد بتخص نتائج الـ
+
+582
+00:48:09,570 --> 00:48:14,870
+control اللي احنا مثلناها على المنحنة فعلياً هي
+
+583
+00:48:14,870 --> 00:48:21,110
+six basic rulesهي 6 قواعد في أكتر بس فعلياً هي 6
+
+584
+00:48:21,110 --> 00:48:26,050
+قواعد اسمها Westgard هذه القواعد أنا ممكن أستخدمها
+
+585
+00:48:26,050 --> 00:48:30,690
+individually يعني أستخدم قاعدة واحدة فردية or in
+
+586
+00:48:30,690 --> 00:48:35,910
+combination أستخدم أكتر من قاعدة والهدف منها عشان
+
+587
+00:48:35,910 --> 00:48:41,550
+أقيم نتائج الـcontrol وأعمل interpretation تحليل
+
+588
+00:48:41,550 --> 00:48:47,500
+لنتائج الـcontrolمعظم الـ Quality Control Rules
+
+589
+00:48:47,500 --> 00:48:53,180
+معظم هذه القواعد تبعت الـ Control بتم التعبير عنها
+
+590
+00:48:53,180 --> 00:48:59,760
+بحاجة اسمها NL N جاية من number و L جاية من
+
+591
+00:48:59,760 --> 00:49:05,540
+statistical limit تمام؟ N number إيه؟ يعني number
+
+592
+00:49:05,540 --> 00:49:15,990
+شو؟الـ N number هو عدد القيم اللي فيهم مشكلة تمام
+
+593
+00:49:15,990 --> 00:49:23,070
+الـ N هي عدد القيم اللي فيهم مشكلة قيم مين؟ قيم
+
+594
+00:49:23,070 --> 00:49:29,670
+الـ controlبمعنى آخر عدد نتائج الـ control اللي
+
+595
+00:49:29,670 --> 00:49:36,030
+فيها المشكلة الـ L هي الـ statistical limit نوضحها
+
+596
+00:49:36,030 --> 00:49:43,910
+أكتر بمثال لو حكيتلك عندي قاعدة القاعدة اسمها 13S
+
+597
+00:49:43,910 --> 00:49:50,780
+تمام، هذه القاعدةكيف بدي أعملها الواحد هذا بيعبّر
+
+598
+00:49:50,780 --> 00:49:57,300
+عن un يعني عندي واحد يعني عندي قيمة واحدة من قيم
+
+599
+00:49:57,300 --> 00:50:03,140
+الـ control فيها مشكلة تلاتة S S معناها SD للـ
+
+600
+00:50:03,140 --> 00:50:07,640
+Standard Deviation تلاتة Standard Deviation معناه
+
+601
+00:50:07,640 --> 00:50:11,920
+هذا الـ statistical limit الحدود الإحصائية إذن
+
+602
+00:50:11,920 --> 00:50:18,850
+معظم قواعدالخاصة بي نتائج الـ Control بتم التعبير
+
+603
+00:50:18,850 --> 00:50:26,550
+عنها برقم وحد إحصائي NL الرقم بيعبر عن عدد النتائج
+
+604
+00:50:26,550 --> 00:50:30,610
+تبع الـ Control اللي فيها مشكلة أكمنتيجة من نتائج
+
+605
+00:50:30,610 --> 00:50:35,750
+الـ Control فيها مشكلة نتيجة، نتيجتين، تلت نتائج؟
+
+606
+00:50:35,750 --> 00:50:39,730
+زي هنا واحد، تلت أس نتيجة واحدة من نتائج الـ
+
+607
+00:50:39,730 --> 00:50:45,090
+Control فيها خلل تلت أسمعنى الكلام إيش تلاتة اسم
+
+608
+00:50:45,090 --> 00:50:49,250
+هذا الحدود الإحصائي تلاتة standard deviation تمام؟
+
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/v_VgjVkzGH0_raw.json b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/v_VgjVkzGH0_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..6f851485174b1fa5aa9120a4462f8d64858f6956
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/v_VgjVkzGH0_raw.json
@@ -0,0 +1 @@
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الجودة من أول ما استلمت العينة لحد ما سجلت النتيجة مش هنجع في الخطأ الـQuality Control يتم تطبيقه في الـ Analytical Phase أما الـQuality Assurance بتتم تطبيقه في التلت مراحل في الـPre Analytical، Analytical، Post Analytical", "tokens": [1211, 2407, 41850, 9122, 39184, 37880, 8337, 9027, 1975, 2655, 3555, 34268, 4724, 2288, 8315, 2304, 7435, 48812, 2304, 7649, 25724, 23328, 3660, 9154, 5551, 12610, 19446, 44713, 19528, 2655, 18863, 9957, 3660, 5296, 24401, 19446, 8608, 7435, 1211, 2655, 28239, 31371, 7435, 3660, 37893, 8032, 1863, 7435, 3615, 8978, 33962, 9566, 10721, 2423, 39184, 48, 901, 507, 12912, 7251, 39237, 6055, 9566, 21292, 4587, 3224, 8978, 2423, 39184, 23688, 804, 24432, 5551, 15042, 2423, 39184, 48, 901, 507, 6281, 5683, 39894, 39237, 6055, 9566, 21292, 4587, 3224, 8978, 16712, 1211, 2655, 3714, 23557, 5016, 1211, 8978, 2423, 39184, 42844, 23688, 804, 12399, 23688, 804, 12399, 10223, 23688, 804], "avg_logprob": -0.1326704586094076, "compression_ratio": 1.6443514644351465, 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"text": "الـ External Quality Control مراقبة الجودة الخارجية هو إجراء إن عرفوا بالإنجليزي is a procedure for utilizing for quality control purposes the results of several laboratories which analyze the same specimens several laboratories إيش يعني؟", "tokens": [6027, 39184, 48277, 28892, 12912, 3714, 23557, 4587, 49401, 25724, 23328, 3660, 33962, 9640, 7435, 10632, 31439, 11933, 7435, 2288, 16606, 36145, 6225, 28480, 14407, 20666, 28814, 1863, 7435, 20292, 11622, 1829, 307, 257, 10747, 337, 26775, 337, 3125, 1969, 9932, 264, 3542, 295, 2940, 41013, 597, 12477, 264, 912, 41007, 2940, 41013, 11933, 1829, 8592, 37495, 22653, 22807], "avg_logprob": -0.17916667386889457, "compression_ratio": 1.3564814814814814, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 501.91, "end": 502.19, "word": "الـ", "probability": 0.941162109375}, {"start": 502.19, "end": 502.71, "word": " External", "probability": 0.734375}, {"start": 502.71, "end": 503.29, "word": " Quality", "probability": 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Analytical Errors are those which occur during the actual performance of the analysis which can be classified into systematic error and random error بيحكيلي الأخطاء التحليلية الحقيقية هي اللي بتحدث أثناء العملية التحليلية أثناء", "tokens": [6027, 39184, 13587, 23688, 804, 3300, 9734, 366, 729, 597, 5160, 1830, 264, 3539, 3389, 295, 264, 5215, 597, 393, 312, 20627, 666, 27249, 6713, 293, 4974, 6713, 4724, 1829, 5016, 4117, 1829, 20292, 16247, 9778, 9566, 16606, 16712, 5016, 20292, 1211, 10632, 21542, 38436, 4587, 10632, 39896, 13672, 1829, 39894, 24401, 12984, 5551, 12984, 1863, 16606, 18863, 42213, 10632, 16712, 5016, 20292, 1211, 10632, 5551, 12984, 1863, 16606], "avg_logprob": -0.15479911246470043, "compression_ratio": 1.497560975609756, "no_speech_prob": 0.0, "words": [{"start": 841.37, "end": 841.67, "word": "الـ", "probability": 0.424591064453125}, {"start": 841.67, "end": 841.93, "word": " True", "probability": 0.576171875}, {"start": 841.93, "end": 842.71, "word": " Analytical", 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الأخطاء إلى قسمين Systematic Error خطأ منهجي and Random Error خطأ عشوائي", "tokens": [6027, 8592, 17082, 1211, 21542, 38436, 38436, 2423, 39184, 3251, 901, 25047, 16247, 3215, 16606, 21542, 38436, 38436, 24976, 2655, 5016, 20292, 1211, 37495, 22653, 5551, 12984, 1863, 16606, 19446, 14739, 2655, 39894, 5016, 1211, 1211, 18863, 9957, 3660, 29538, 5551, 9778, 9566, 16606, 11331, 38436, 4587, 10632, 10874, 2407, 3224, 2288, 10632, 5551, 12984, 1863, 16606, 16712, 5016, 20292, 1211, 13672, 1829, 39894, 24401, 12984, 34683, 4587, 38251, 16247, 9778, 9566, 16606, 30731, 12174, 38251, 9957, 8910, 2399, 3300, 2874, 16490, 9566, 10721, 9154, 3224, 7435, 1829, 293, 37603, 3300, 2874, 16490, 9566, 10721, 6225, 8592, 2407, 16373, 1829], "avg_logprob": -0.06946163012249636, "compression_ratio": 1.640552995391705, "no_speech_prob": 7.748603820800781e-07, "words": [{"start": 864.57, "end": 865.69, "word": "الشغل", "probability": 0.9853515625}, {"start": 865.69, "end": 866.57, "word": " الحقيقي", 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المنهجي بدي أتعرف عليه كيف لو جبتي عينة control", "tokens": [6027, 39184, 8910, 2399, 3300, 9734, 33962, 9566, 10721, 9673, 1863, 3224, 7435, 1829, 322, 10477, 5215, 295, 264, 6889, 321, 815, 611, 915, 4190, 412, 2085, 1496, 886, 1090, 420, 886, 2295, 4724, 5016, 4117, 1829, 24976, 9778, 9566, 10721, 9673, 1863, 3224, 7435, 1829, 4724, 16254, 5551, 2655, 3615, 28480, 47356, 9122, 33911, 45164, 10874, 3555, 31371, 6225, 9957, 3660, 1969], "avg_logprob": -0.17382812197320163, "compression_ratio": 1.326086956521739, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 888.91, "end": 889.23, "word": "الـ", "probability": 0.889404296875}, {"start": 889.23, "end": 889.89, "word": " Systematic", "probability": 0.820068359375}, {"start": 889.89, "end": 890.39, "word": " Errors", "probability": 0.736572265625}, {"start": 890.39, "end": 891.07, "word": " الخطأ", "probability": 0.9313151041666666}, {"start": 891.07, "end": 891.97, "word": " المنهجي", "probability": 0.978125}, {"start": 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صحيحة ونتجتين طلعوا كتير بعد سواء عليين أو واطين معناه في عندي systematic error خطأ منهجين", "tokens": [2407, 25957, 1211, 2655, 6156, 5016, 9381, 21136, 37983, 5296, 3615, 9957, 3660, 1969, 6225, 46309, 3714, 2288, 9307, 46811, 28239, 2655, 16373, 7435, 20328, 5016, 1829, 5016, 3660, 4032, 29399, 7435, 2655, 9957, 23032, 1211, 3615, 14407, 9122, 2655, 13546, 45030, 3215, 8608, 2407, 16606, 25894, 9957, 34051, 4032, 41193, 9957, 20449, 8315, 3224, 8978, 18871, 16254, 27249, 6713, 16490, 9566, 10721, 9154, 3224, 7435, 9957], "avg_logprob": -0.1464843693024972, "compression_ratio": 1.401197604790419, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 989.04, "end": 989.66, "word": "وعملت", "probability": 0.9312744140625}, {"start": 989.66, "end": 990.04, "word": " فحص", "probability": 0.9773763020833334}, {"start": 990.04, "end": 990.62, "word": " السكر", "probability": 0.886962890625}, {"start": 990.62, "end": 992.64, "word": " لعينة", "probability": 0.887451171875}, 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{"start": 1000.28, "end": 1000.64, "word": " أو", "probability": 0.6640625}, {"start": 1000.64, "end": 1001.36, "word": " واطين", "probability": 0.735595703125}, {"start": 1001.36, "end": 1002.04, "word": " معناه", "probability": 0.9339192708333334}, {"start": 1002.04, "end": 1002.18, "word": " في", "probability": 0.80859375}, {"start": 1002.18, "end": 1002.58, "word": " عندي", "probability": 0.779296875}, {"start": 1002.58, "end": 1003.2, "word": " systematic", "probability": 0.6357421875}, {"start": 1003.2, "end": 1003.84, "word": " error", "probability": 0.9404296875}, {"start": 1003.84, "end": 1004.44, "word": " خطأ", "probability": 0.9664713541666666}, {"start": 1004.44, "end": 1005.16, "word": " منهجين", "probability": 0.9254150390625}], "temperature": 1.0}, {"id": 48, "seek": 102633, "start": 1005.73, "end": 1026.33, "text": "Which can be due to قد تكون أسبابه analytical method مشكلة في طريقة التحليل أو ال technical performance في أداء أخصاء التحليل في طريقة شغله مشكلة في ال reagent مشكلة في ال measuring equipment في المعدات المستخدمة في التحليل و بالأخص ال bybit", "tokens": [33785, 393, 312, 3462, 281, 12174, 3215, 6055, 30544, 5551, 35457, 16758, 3224, 29579, 3170, 37893, 28820, 3660, 8978, 23032, 16572, 28671, 16712, 5016, 20292, 1211, 34051, 2423, 6191, 3389, 8978, 5551, 3215, 16606, 5551, 9778, 9381, 16606, 16712, 5016, 20292, 1211, 8978, 23032, 16572, 28671, 13412, 17082, 43761, 37893, 28820, 3660, 8978, 2423, 26949, 317, 37893, 28820, 3660, 8978, 2423, 13389, 5927, 8978, 9673, 22488, 9307, 9673, 14851, 9778, 40448, 3660, 8978, 16712, 5016, 20292, 1211, 4032, 20666, 10721, 9778, 9381, 2423, 538, 5260], "avg_logprob": -0.11010174314643062, "compression_ratio": 1.7095238095238094, "no_speech_prob": 8.344650268554688e-07, "words": [{"start": 1005.73, "end": 1006.39, "word": "Which", "probability": 0.61328125}, {"start": 1006.39, "end": 1006.73, "word": " can", "probability": 0.908203125}, {"start": 1006.73, "end": 1006.99, "word": " be", "probability": 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1024.43, "end": 1024.91, "word": " التحليل", "probability": 0.9913330078125}, {"start": 1024.91, "end": 1025.07, "word": " و", "probability": 0.54248046875}, {"start": 1025.07, "end": 1025.69, "word": " بالأخص", "probability": 0.9390869140625}, {"start": 1025.69, "end": 1025.85, "word": " ال", "probability": 0.91357421875}, {"start": 1025.85, "end": 1026.33, "word": " bybit", "probability": 0.4161376953125}], "temperature": 1.0}, {"id": 49, "seek": 104849, "start": 1027.01, "end": 1048.49, "text": "مشكلة بالـ Technicians نفسه تبع التحليل أخصاء التحليل There are two types of systematic errors عندي نوعين لـ systematic error خطأ ثابت وخطأ متناسب constant error ثابت و الخطأ ال proportional error الخطأ المتناسب ال constant error الخطأ الثابت", "tokens": [2304, 8592, 28820, 3660, 20666, 39184, 8337, 8455, 8717, 36178, 3224, 6055, 3555, 3615, 16712, 5016, 20292, 1211, 5551, 9778, 9381, 16606, 16712, 5016, 20292, 1211, 821, 366, 732, 3467, 295, 27249, 13603, 18871, 16254, 8717, 45367, 9957, 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أخصاء", "probability": 0.7928466796875}, {"start": 1030.83, "end": 1031.45, "word": " التحليل", "probability": 0.991455078125}, {"start": 1031.45, "end": 1032.03, "word": " There", "probability": 0.154052734375}, {"start": 1032.03, "end": 1032.29, "word": " are", "probability": 0.96337890625}, {"start": 1032.29, "end": 1032.51, "word": " two", "probability": 0.89892578125}, {"start": 1032.51, "end": 1033.01, "word": " types", "probability": 0.830078125}, {"start": 1033.01, "end": 1033.23, "word": " of", "probability": 0.9775390625}, {"start": 1033.23, "end": 1033.77, "word": " systematic", "probability": 0.471923828125}, {"start": 1033.77, "end": 1034.33, "word": " errors", "probability": 0.72314453125}, {"start": 1034.33, "end": 1034.73, "word": " عندي", "probability": 0.6597900390625}, {"start": 1034.73, "end": 1035.29, "word": " نوعين", "probability": 0.9912109375}, {"start": 1035.29, "end": 1035.87, "word": " لـ", "probability": 0.853271484375}, {"start": 1035.87, "end": 1036.37, "word": " systematic", "probability": 0.2568359375}, {"start": 1036.37, "end": 1036.93, "word": " error", "probability": 0.798828125}, {"start": 1036.93, "end": 1037.71, "word": " خطأ", "probability": 0.98828125}, {"start": 1037.71, "end": 1038.29, "word": " ثابت", "probability": 0.9912109375}, {"start": 1038.29, "end": 1038.83, "word": " وخطأ", "probability": 0.9327392578125}, {"start": 1038.83, "end": 1039.61, "word": " متناسب", "probability": 0.9669596354166666}, {"start": 1039.61, "end": 1040.21, "word": " constant", "probability": 0.5859375}, {"start": 1040.21, "end": 1040.81, "word": " error", "probability": 0.962890625}, {"start": 1040.81, "end": 1041.53, "word": " ثابت", "probability": 0.9827473958333334}, {"start": 1041.53, "end": 1041.99, "word": " و", "probability": 0.74853515625}, {"start": 1041.99, "end": 1042.67, "word": " الخطأ", "probability": 0.9150390625}, {"start": 1042.67, "end": 1042.81, "word": " ال", "probability": 0.57373046875}, {"start": 1042.81, "end": 1043.37, "word": " proportional", "probability": 0.62255859375}, {"start": 1043.37, "end": 1043.93, "word": " error", "probability": 0.90234375}, {"start": 1043.93, "end": 1044.55, "word": " الخطأ", "probability": 0.9881184895833334}, {"start": 1044.55, "end": 1045.53, "word": " المتناسب", "probability": 0.970703125}, {"start": 1045.53, "end": 1046.13, "word": " ال", "probability": 0.93505859375}, {"start": 1046.13, "end": 1046.55, "word": " constant", "probability": 0.48779296875}, {"start": 1046.55, "end": 1047.09, "word": " error", "probability": 0.958984375}, {"start": 1047.09, "end": 1047.81, "word": " الخطأ", "probability": 0.9842122395833334}, {"start": 1047.81, "end": 1048.49, "word": " الثابت", "probability": 0.956787109375}], "temperature": 1.0}, {"id": 50, "seek": 107333, "start": 1049.18, "end": 1073.34, "text": "إيش تعريفه؟ Error in a test system in which the amount of error remains constant throughout the range of the test process هو عبارة عن الخطأ اللي بيصير أثناء عملية التحليل ويبقى ثابت هذا الخطأ ال amount حجمه remains constant عشان هيك سموه الخطأ الثابت حجم هذا الخطأ يبقى ثابت", "tokens": [28814, 1829, 8592, 37279, 16572, 5172, 3224, 22807, 3300, 2874, 294, 257, 1500, 1185, 294, 597, 264, 2372, 295, 6713, 7023, 5754, 3710, 264, 3613, 295, 264, 1500, 1399, 31439, 6225, 3555, 9640, 3660, 18871, 33962, 9566, 10721, 13672, 1829, 4724, 1829, 9381, 13546, 5551, 12984, 1863, 16606, 6225, 42213, 10632, 16712, 5016, 20292, 1211, 4032, 1829, 3555, 4587, 7578, 38637, 16758, 2655, 23758, 33962, 9566, 10721, 2423, 2372, 11331, 7435, 2304, 3224, 7023, 5754, 6225, 8592, 7649, 39896, 4117, 8608, 2304, 2407, 3224, 33962, 9566, 10721, 6024, 104, 16758, 2655, 11331, 7435, 2304, 23758, 33962, 9566, 10721, 7251, 3555, 4587, 7578, 38637, 16758, 2655], "avg_logprob": -0.11534493205682286, "compression_ratio": 1.6652360515021458, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 1049.18, "end": 1049.5, "word": "إيش", "probability": 0.6112467447916666}, {"start": 1049.5, "end": 1050.56, "word": " تعريفه؟", "probability": 0.801513671875}, {"start": 1050.56, "end": 1050.86, "word": " Error", "probability": 0.762939453125}, {"start": 1050.86, "end": 1051.16, "word": " in", "probability": 0.96630859375}, {"start": 1051.16, "end": 1051.42, "word": " a", "probability": 0.97802734375}, {"start": 1051.42, "end": 1051.72, "word": " test", "probability": 0.8271484375}, {"start": 1051.72, "end": 1052.4, "word": " system", "probability": 0.9462890625}, {"start": 1052.4, "end": 1052.88, "word": " in", "probability": 0.892578125}, {"start": 1052.88, "end": 1053.12, "word": " which", "probability": 0.96875}, {"start": 1053.12, "end": 1053.32, "word": " the", "probability": 0.84765625}, {"start": 1053.32, "end": 1053.74, "word": " amount", "probability": 0.85205078125}, {"start": 1053.74, "end": 1053.98, "word": " of", "probability": 0.97412109375}, {"start": 1053.98, "end": 1054.28, "word": " error", "probability": 0.90869140625}, {"start": 1054.28, "end": 1054.8, "word": " remains", "probability": 0.80419921875}, {"start": 1054.8, "end": 1055.4, "word": " constant", "probability": 0.939453125}, {"start": 1055.4, "end": 1055.94, "word": " throughout", "probability": 0.80810546875}, {"start": 1055.94, "end": 1056.36, "word": " the", "probability": 0.9326171875}, {"start": 1056.36, "end": 1056.72, "word": " range", "probability": 0.92236328125}, {"start": 1056.72, "end": 1057.0, "word": " of", "probability": 0.98388671875}, {"start": 1057.0, "end": 1057.22, "word": " the", "probability": 0.8857421875}, {"start": 1057.22, "end": 1057.62, "word": " test", "probability": 0.8857421875}, {"start": 1057.62, "end": 1058.28, "word": " process", "probability": 0.9111328125}, {"start": 1058.28, "end": 1058.7, "word": " هو", "probability": 0.45556640625}, {"start": 1058.7, "end": 1059.12, "word": " عبارة", "probability": 0.9957275390625}, {"start": 1059.12, "end": 1059.28, "word": " عن", "probability": 0.99755859375}, {"start": 1059.28, "end": 1059.8, "word": " الخطأ", "probability": 0.9939778645833334}, {"start": 1059.8, "end": 1060.1, "word": " اللي", "probability": 0.96728515625}, {"start": 1060.1, "end": 1060.48, "word": " بيصير", "probability": 0.8902587890625}, {"start": 1060.48, "end": 1060.94, "word": " أثناء", "probability": 0.97314453125}, {"start": 1060.94, "end": 1061.6, "word": " عملية", "probability": 0.9905598958333334}, {"start": 1061.6, "end": 1062.58, "word": " التحليل", "probability": 0.974609375}, {"start": 1062.58, "end": 1063.84, "word": " ويبقى", "probability": 0.9830078125}, {"start": 1063.84, "end": 1064.48, "word": " ثابت", "probability": 0.9967447916666666}, {"start": 1064.48, "end": 1064.88, "word": " هذا", "probability": 0.84716796875}, {"start": 1064.88, "end": 1065.48, "word": " الخطأ", "probability": 0.99560546875}, {"start": 1065.48, "end": 1066.1, "word": " ال", "probability": 0.80322265625}, {"start": 1066.1, "end": 1066.7, "word": " amount", "probability": 0.7041015625}, {"start": 1066.7, "end": 1067.54, "word": " حجمه", "probability": 0.9581298828125}, {"start": 1067.54, "end": 1068.14, "word": " remains", "probability": 0.85205078125}, {"start": 1068.14, "end": 1068.84, "word": " constant", "probability": 0.93505859375}, {"start": 1068.84, "end": 1069.16, "word": " عشان", "probability": 0.9602864583333334}, {"start": 1069.16, "end": 1069.34, "word": " هيك", "probability": 0.935546875}, {"start": 1069.34, "end": 1069.64, "word": " سموه", "probability": 0.8116455078125}, {"start": 1069.64, "end": 1069.96, "word": " الخطأ", "probability": 0.9217122395833334}, {"start": 1069.96, "end": 1070.42, "word": " الثابت", "probability": 0.81658935546875}, {"start": 1070.42, "end": 1071.02, "word": " حجم", "probability": 0.91552734375}, {"start": 1071.02, "end": 1071.26, "word": " هذا", "probability": 0.98193359375}, {"start": 1071.26, "end": 1071.74, "word": " الخطأ", "probability": 0.9920247395833334}, {"start": 1071.74, "end": 1072.74, "word": " يبقى", "probability": 0.9945068359375}, {"start": 1072.74, "end": 1073.34, "word": " ثابت", "probability": 0.9962565104166666}], "temperature": 1.0}, {"id": 51, "seek": 109689, "start": 1073.99, "end": 1096.89, "text": "مهما زاد تركيز الـ Analyte اللي أنا بدي أجيسه في العينة لو كان السكر 70 أو كان السكر 80 اللي موجود في العينة أو كان السكر تركيزه 100 أو 200 أو 300 أو 600 هذا الـ Constant Error مهما زاد تركيز الـ Analyte في العينة", "tokens": [2304, 3224, 15042, 30767, 18513, 6055, 31747, 1829, 11622, 2423, 39184, 1107, 5222, 975, 13672, 1829, 41850, 4724, 16254, 5551, 7435, 1829, 3794, 3224, 8978, 18863, 9957, 3660, 45164, 25961, 21136, 37983, 5285, 34051, 25961, 21136, 37983, 4688, 13672, 1829, 3714, 29245, 23328, 8978, 18863, 9957, 3660, 34051, 25961, 21136, 37983, 6055, 31747, 1829, 11622, 3224, 2319, 34051, 2331, 34051, 6641, 34051, 11849, 23758, 2423, 39184, 37413, 3300, 2874, 3714, 3224, 15042, 30767, 18513, 6055, 31747, 1829, 11622, 2423, 39184, 1107, 5222, 975, 8978, 18863, 9957, 3660], "avg_logprob": -0.11061789967458356, "compression_ratio": 1.9709302325581395, "no_speech_prob": 0.0, "words": [{"start": 1073.99, "end": 1074.81, "word": "مهما", "probability": 0.8624674479166666}, {"start": 1074.81, "end": 1075.67, "word": " زاد", "probability": 0.720947265625}, {"start": 1075.67, "end": 1076.75, "word": " تركيز", "probability": 0.98388671875}, {"start": 1076.75, "end": 1077.21, "word": " الـ", "probability": 0.87890625}, {"start": 1077.21, "end": 1077.79, "word": " Analyte", "probability": 0.7530924479166666}, {"start": 1077.79, "end": 1078.19, "word": " اللي", "probability": 0.902099609375}, {"start": 1078.19, "end": 1078.39, "word": " أنا", "probability": 0.73828125}, {"start": 1078.39, "end": 1078.77, "word": " بدي", "probability": 0.78466796875}, {"start": 1078.77, "end": 1079.45, "word": " أجيسه", "probability": 0.88447265625}, {"start": 1079.45, "end": 1079.85, "word": " في", "probability": 0.9775390625}, {"start": 1079.85, "end": 1080.61, "word": " العينة", "probability": 0.9554036458333334}, {"start": 1080.61, "end": 1080.97, "word": " لو", "probability": 0.81591796875}, {"start": 1080.97, "end": 1081.25, "word": " كان", "probability": 0.9921875}, {"start": 1081.25, "end": 1081.67, "word": " السكر", "probability": 0.903076171875}, {"start": 1081.67, "end": 1082.15, "word": " 70", "probability": 0.8701171875}, {"start": 1082.15, "end": 1082.79, "word": " أو", "probability": 0.90087890625}, {"start": 1082.79, "end": 1083.11, "word": " كان", "probability": 0.95947265625}, {"start": 1083.11, "end": 1083.53, "word": " السكر", "probability": 0.97900390625}, {"start": 1083.53, "end": 1084.05, "word": " 80", "probability": 0.98046875}, {"start": 1084.05, "end": 1084.37, "word": " اللي", "probability": 0.938232421875}, {"start": 1084.37, "end": 1084.69, "word": " موجود", "probability": 0.9908854166666666}, {"start": 1084.69, "end": 1084.81, "word": " في", "probability": 0.96240234375}, {"start": 1084.81, "end": 1085.33, "word": " العينة", "probability": 0.9778645833333334}, {"start": 1085.33, "end": 1085.83, "word": " أو", "probability": 0.96435546875}, {"start": 1085.83, "end": 1086.07, "word": " كان", "probability": 0.98876953125}, {"start": 1086.07, "end": 1086.55, "word": " السكر", "probability": 0.97998046875}, {"start": 1086.55, "end": 1087.29, "word": " تركيزه", "probability": 0.98466796875}, {"start": 1087.29, "end": 1087.59, "word": " 100", "probability": 0.86376953125}, {"start": 1087.59, "end": 1088.07, "word": " أو", "probability": 0.84912109375}, {"start": 1088.07, "end": 1088.55, "word": " 200", "probability": 0.9677734375}, {"start": 1088.55, "end": 1088.93, "word": " أو", "probability": 0.94482421875}, {"start": 1088.93, "end": 1089.43, "word": " 300", "probability": 0.9765625}, {"start": 1089.43, "end": 1089.87, "word": " أو", "probability": 0.951171875}, {"start": 1089.87, "end": 1090.43, "word": " 600", "probability": 0.98388671875}, {"start": 1090.43, "end": 1091.33, "word": " هذا", "probability": 0.76513671875}, {"start": 1091.33, "end": 1091.57, "word": " الـ", "probability": 0.872314453125}, {"start": 1091.57, "end": 1091.93, "word": " Constant", "probability": 0.367919921875}, {"start": 1091.93, "end": 1092.57, "word": " Error", "probability": 0.889892578125}, {"start": 1092.57, "end": 1093.41, "word": " مهما", "probability": 0.9109700520833334}, {"start": 1093.41, "end": 1093.89, "word": " زاد", "probability": 0.9853515625}, {"start": 1093.89, "end": 1094.87, "word": " تركيز", "probability": 0.9971923828125}, {"start": 1094.87, "end": 1095.25, "word": " الـ", "probability": 0.8662109375}, {"start": 1095.25, "end": 1095.85, "word": " Analyte", "probability": 0.7900390625}, {"start": 1095.85, "end": 1096.13, "word": " في", "probability": 0.98486328125}, {"start": 1096.13, "end": 1096.89, "word": " العينة", "probability": 0.9873046875}], "temperature": 1.0}, {"id": 52, "seek": 112402, "start": 1097.38, "end": 1124.02, "text": "يبقى ثابت كما هو وما بيتغير له نسبة ثابتة الـ Constant Error أما الـ Proportional Error الخطأ المتناسب Error in a test system in which the amount of error increases the concentration of the substance being measured هو عبارة عن الخطأ اللي بيصير أثناء عملية التحليل", "tokens": [1829, 3555, 4587, 7578, 38637, 16758, 2655, 9122, 15042, 31439, 4032, 15042, 4724, 36081, 17082, 13546, 46740, 8717, 35457, 3660, 38637, 16758, 2655, 3660, 2423, 39184, 37413, 3300, 2874, 5551, 15042, 2423, 39184, 21944, 477, 1966, 3300, 2874, 33962, 9566, 10721, 9673, 2655, 8315, 35457, 3300, 2874, 294, 257, 1500, 1185, 294, 597, 264, 2372, 295, 6713, 294, 14066, 1957, 264, 9856, 295, 264, 12961, 885, 12690, 31439, 6225, 3555, 9640, 3660, 18871, 33962, 9566, 10721, 13672, 1829, 4724, 1829, 9381, 13546, 5551, 12984, 1863, 16606, 6225, 42213, 10632, 16712, 5016, 20292, 1211], "avg_logprob": -0.09000997601988468, "compression_ratio": 1.5169491525423728, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 1097.38, "end": 1098.46, "word": "يبقى", "probability": 0.9691162109375}, {"start": 1098.46, "end": 1099.32, "word": " ثابت", "probability": 0.9912109375}, {"start": 1099.32, "end": 1099.68, "word": " كما", "probability": 0.97265625}, {"start": 1099.68, "end": 1100.02, "word": " هو", "probability": 0.99853515625}, {"start": 1100.02, "end": 1101.12, "word": " وما", "probability": 0.913330078125}, {"start": 1101.12, "end": 1101.84, "word": " بيتغير", "probability": 0.9775390625}, {"start": 1101.84, "end": 1102.16, "word": " له", "probability": 0.51318359375}, {"start": 1102.16, "end": 1102.68, "word": " نسبة", "probability": 0.99462890625}, {"start": 1102.68, "end": 1103.52, "word": " ثابتة", "probability": 0.96923828125}, {"start": 1103.52, "end": 1103.88, "word": " الـ", "probability": 0.927001953125}, {"start": 1103.88, "end": 1104.4, "word": " Constant", "probability": 0.6767578125}, {"start": 1104.4, "end": 1104.78, "word": " Error", "probability": 0.87255859375}, {"start": 1104.78, "end": 1105.62, "word": " أما", 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which", "probability": 0.96435546875}, {"start": 1111.82, "end": 1112.02, "word": " the", "probability": 0.85107421875}, {"start": 1112.02, "end": 1112.54, "word": " amount", "probability": 0.88525390625}, {"start": 1112.54, "end": 1112.96, "word": " of", "probability": 0.87939453125}, {"start": 1112.96, "end": 1114.02, "word": " error", "probability": 0.9384765625}, {"start": 1114.02, "end": 1115.24, "word": " increases", "probability": 0.7210286458333334}, {"start": 1115.24, "end": 1115.5, "word": " the", "probability": 0.830078125}, {"start": 1115.5, "end": 1116.38, "word": " concentration", "probability": 0.88720703125}, {"start": 1116.38, "end": 1116.9, "word": " of", "probability": 0.97705078125}, {"start": 1116.9, "end": 1117.1, "word": " the", "probability": 0.85205078125}, {"start": 1117.1, "end": 1117.74, "word": " substance", "probability": 0.931640625}, {"start": 1117.74, "end": 1118.44, "word": " being", "probability": 0.939453125}, {"start": 1118.44, "end": 1119.08, 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إن الـ Proportional Error هذا الخطأ المتناسب ما بيظل ثابت بيزداد حجم هذا الخطأ كل ما زاد تركيز مثلا الـ Analyte اللي هو مثلا السكر اللي موجود في العينة مثلا لو إيجتني عينة سكرها 70", "tokens": [5016, 7435, 2304, 23758, 33962, 9566, 10721, 7251, 11622, 3215, 18513, 4724, 11622, 1829, 18513, 3660, 6055, 31747, 1829, 11622, 2423, 39184, 1107, 5222, 975, 10874, 2407, 11703, 9307, 18863, 9957, 3660, 11933, 15730, 27188, 2288, 4587, 49374, 3224, 46599, 9957, 2423, 39184, 37413, 3300, 2874, 36145, 2423, 39184, 21944, 477, 1966, 3300, 2874, 23758, 33962, 9566, 10721, 9673, 2655, 8315, 35457, 19446, 4724, 1829, 19913, 1211, 38637, 16758, 2655, 4724, 1829, 11622, 3215, 18513, 11331, 7435, 2304, 23758, 33962, 9566, 10721, 28242, 19446, 30767, 18513, 6055, 31747, 1829, 11622, 50113, 15040, 2423, 39184, 1107, 5222, 975, 13672, 1829, 31439, 50113, 15040, 21136, 37983, 13672, 1829, 3714, 29245, 23328, 8978, 18863, 9957, 3660, 50113, 15040, 45164, 11933, 1829, 7435, 2655, 22653, 6225, 9957, 3660, 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زاد", "probability": 0.988037109375}, {"start": 1146.17, "end": 1146.89, "word": " تركيز", "probability": 0.9912109375}, {"start": 1146.89, "end": 1147.39, "word": " مثلا", "probability": 0.884765625}, {"start": 1147.39, "end": 1147.87, "word": " الـ", "probability": 0.9501953125}, {"start": 1147.87, "end": 1148.39, "word": " Analyte", "probability": 0.77734375}, {"start": 1148.39, "end": 1148.57, "word": " اللي", "probability": 0.8095703125}, {"start": 1148.57, "end": 1148.75, "word": " هو", "probability": 0.99072265625}, {"start": 1148.75, "end": 1149.19, "word": " مثلا", "probability": 0.9521484375}, {"start": 1149.19, "end": 1149.83, "word": " السكر", "probability": 0.85009765625}, {"start": 1149.83, "end": 1150.33, "word": " اللي", "probability": 0.841064453125}, {"start": 1150.33, "end": 1150.73, "word": " موجود", "probability": 0.9899088541666666}, {"start": 1150.73, "end": 1150.85, "word": " في", "probability": 0.97998046875}, {"start": 1150.85, "end": 1151.35, "word": " العينة", "probability": 0.9778645833333334}, {"start": 1151.35, "end": 1151.93, "word": " مثلا", "probability": 0.9345703125}, {"start": 1151.93, "end": 1152.11, "word": " لو", "probability": 0.86572265625}, {"start": 1152.11, "end": 1152.61, "word": " إيجتني", "probability": 0.7771484375}, {"start": 1152.61, "end": 1153.15, "word": " عينة", "probability": 0.9749348958333334}, {"start": 1153.15, "end": 1153.93, "word": " سكرها", "probability": 0.9137369791666666}, {"start": 1153.93, "end": 1154.37, "word": " 70", "probability": 0.802734375}], "temperature": 1.0}, {"id": 54, "seek": 117286, "start": 1154.65, "end": 1172.87, "text": "الها نسبة خطأ معينة طيب لو زودت تركيز السكر خليته 200 نسبة الخطأ هتزيد إذا نسبة الخطأ تزداد بزيادة تركيز الانالايت اللي أنا بدي أجيسه داخل العينة", "tokens": [6027, 11296, 8717, 35457, 3660, 16490, 9566, 10721, 20449, 9957, 3660, 23032, 1829, 3555, 45164, 30767, 23328, 2655, 6055, 31747, 1829, 11622, 21136, 37983, 16490, 20292, 47395, 2331, 8717, 35457, 3660, 33962, 9566, 10721, 8032, 2655, 11622, 25708, 11933, 15730, 8717, 35457, 3660, 33962, 9566, 10721, 6055, 11622, 3215, 18513, 4724, 11622, 1829, 18513, 3660, 6055, 31747, 1829, 11622, 2423, 7649, 6027, 995, 36081, 13672, 1829, 41850, 4724, 16254, 5551, 7435, 1829, 3794, 3224, 11778, 47283, 1211, 18863, 9957, 3660], "avg_logprob": -0.10831404615331579, "compression_ratio": 1.7635135135135136, "no_speech_prob": 2.2649765014648438e-06, "words": [{"start": 1154.65, "end": 1155.61, "word": "الها", "probability": 0.62939453125}, {"start": 1155.61, "end": 1156.07, "word": " نسبة", "probability": 0.9915364583333334}, {"start": 1156.07, "end": 1156.45, "word": " خطأ", "probability": 0.9947916666666666}, {"start": 1156.45, "end": 1157.11, "word": " معينة", "probability": 0.97607421875}, {"start": 1157.11, "end": 1157.79, "word": " طيب", "probability": 0.8819986979166666}, {"start": 1157.79, "end": 1158.03, "word": " لو", "probability": 0.8564453125}, {"start": 1158.03, "end": 1158.89, "word": " زودت", "probability": 0.9186197916666666}, {"start": 1158.89, "end": 1159.43, "word": " تركيز", "probability": 0.991455078125}, {"start": 1159.43, "end": 1159.93, "word": " السكر", "probability": 0.861572265625}, {"start": 1159.93, "end": 1160.49, "word": " خليته", "probability": 0.64599609375}, {"start": 1160.49, "end": 1160.93, "word": " 200", "probability": 0.8916015625}, {"start": 1160.93, "end": 1161.99, "word": " نسبة", "probability": 0.943359375}, {"start": 1161.99, "end": 1162.51, "word": " الخطأ", "probability": 0.99658203125}, {"start": 1162.51, "end": 1163.25, "word": " هتزيد", "probability": 0.942138671875}, {"start": 1163.25, "end": 1163.75, "word": " إذا", "probability": 0.656982421875}, {"start": 1163.75, "end": 1164.51, "word": " نسبة", "probability": 0.94970703125}, {"start": 1164.51, "end": 1165.03, "word": " الخطأ", "probability": 0.9947916666666666}, {"start": 1165.03, "end": 1166.05, "word": " تزداد", "probability": 0.9759521484375}, {"start": 1166.05, "end": 1167.73, "word": " بزيادة", "probability": 0.98876953125}, {"start": 1167.73, "end": 1168.51, "word": " تركيز", "probability": 0.9949951171875}, {"start": 1168.51, "end": 1169.29, "word": " الانالايت", "probability": 0.810888671875}, {"start": 1169.29, "end": 1169.73, "word": " اللي", "probability": 0.86083984375}, {"start": 1169.73, "end": 1169.99, "word": " أنا", "probability": 0.6328125}, {"start": 1169.99, "end": 1170.57, "word": " بدي", "probability": 0.8603515625}, {"start": 1170.57, "end": 1171.25, "word": " أجيسه", "probability": 0.9443359375}, {"start": 1171.25, "end": 1172.01, "word": " داخل", "probability": 0.9658203125}, {"start": 1172.01, "end": 1172.87, "word": " العينة", "probability": 0.9319661458333334}], "temperature": 1.0}, {"id": 55, "seek": 119211, "start": 1174.82, "end": 1192.12, "text": "لو جينا برجع بعيد نفس الكلام بحكي عن الـTypes of Systematic Error عن أنواع الخطأ المنهج حكينا Proportional Error خطأ متناسب and Constant Error وخطأ ثابت بالنسبة لـProportional Error في كمان تعريف له", "tokens": [1211, 2407, 10874, 1829, 8315, 4724, 47341, 3615, 45030, 25708, 8717, 36178, 2423, 28820, 10943, 4724, 5016, 4117, 1829, 18871, 2423, 39184, 22464, 5190, 295, 8910, 2399, 3300, 2874, 18871, 14739, 14407, 3615, 33962, 9566, 10721, 9673, 1863, 3224, 7435, 11331, 4117, 1829, 8315, 21944, 477, 1966, 3300, 2874, 16490, 9566, 10721, 44650, 8315, 35457, 293, 37413, 3300, 2874, 4032, 9778, 9566, 10721, 38637, 16758, 2655, 20666, 1863, 35457, 3660, 5296, 39184, 12681, 2707, 1966, 3300, 2874, 8978, 9122, 2304, 7649, 37279, 16572, 5172, 46740], "avg_logprob": -0.10219840289548386, "compression_ratio": 1.489795918367347, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 1174.82, "end": 1175.38, "word": "لو", "probability": 0.979248046875}, {"start": 1175.38, "end": 1175.76, "word": " جينا", "probability": 0.9847005208333334}, {"start": 1175.76, "end": 1176.42, "word": " برجع", "probability": 0.8924153645833334}, {"start": 1176.42, 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"probability": 0.9659423828125}, {"start": 1189.0, "end": 1190.16, "word": " لـProportional", "probability": 0.813330078125}, {"start": 1190.16, "end": 1190.54, "word": " Error", "probability": 0.97705078125}, {"start": 1190.54, "end": 1190.74, "word": " في", "probability": 0.76025390625}, {"start": 1190.74, "end": 1191.26, "word": " كمان", "probability": 0.8299967447916666}, {"start": 1191.26, "end": 1191.84, "word": " تعريف", "probability": 0.9943033854166666}, {"start": 1191.84, "end": 1192.12, "word": " له", "probability": 0.912109375}], "temperature": 1.0}, {"id": 56, "seek": 121732, "start": 1192.5, "end": 1217.32, "text": "The magnitude of the error grows with the concentration of the material being measured هو الخطأ اللي بيزداد تزداد نسبته بزيادة تركيز الانالايت اللي موجود في العينة زي ما احنا شايفين بالرسم الأولى بتعبر عن ال proportional error في عندى علاقة ترضية مابين", "tokens": [2278, 15668, 295, 264, 6713, 13156, 365, 264, 9856, 295, 264, 2527, 885, 12690, 31439, 33962, 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"start": 1799.9, "end": 1828.0, "text": "التقارب، الإحكام أو بيسموه الـ Reproducibility معناه إنت إيش يعني Reproducibility؟ لما تعمل إعادة للفحص أكتر من مرة هتلاقي النتائج هي نفسها متقاربة هي عندنا أكتر من سهم، عملت الفحص أكتر من مرة يعني عندي أكتر من سهم وكل الأسهم زي ما إحنا شايفين متقاربة معناه فيه precision عالي، عندنا إحكام عالي", "tokens": [6027, 2655, 4587, 9640, 3555, 12399, 33688, 5016, 4117, 10943, 34051, 4724, 1829, 38251, 2407, 3224, 2423, 39184, 3696, 2323, 537, 39802, 20449, 8315, 3224, 11933, 29399, 11933, 1829, 8592, 37495, 22653, 3696, 2323, 537, 39802, 22807, 5296, 15042, 6055, 25957, 1211, 11933, 3615, 18513, 3660, 24976, 5172, 5016, 9381, 5551, 4117, 2655, 2288, 9154, 3714, 25720, 8032, 2655, 15040, 38436, 28239, 2655, 16373, 7435, 39896, 8717, 36178, 11296, 44650, 4587, 9640, 49401, 39896, 43242, 8315, 5551, 4117, 2655, 2288, 9154, 8608, 16095, 12399, 6225, 42213, 2655, 27188, 5016, 9381, 5551, 4117, 2655, 2288, 9154, 3714, 25720, 37495, 22653, 18871, 16254, 5551, 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ثمرة كبيرة بالنص هذه النقطة الثمرة الكبيرة بالنص بتعبر أنه أنا كانت عندي عينة وجبت كت السكر واشتغلت هذه العينة أكتر من مرة", "tokens": [1211, 2407, 11933, 1829, 7435, 1829, 8315, 24976, 2288, 38251, 3660, 13672, 1829, 5551, 2304, 10943, 8315, 16490, 1211, 9957, 995, 8717, 2655, 9566, 1211, 3615, 8978, 34892, 38251, 2655, 9957, 13672, 1829, 6156, 30543, 20666, 10721, 12610, 34892, 38251, 3660, 13672, 1829, 15844, 2423, 32640, 9957, 8032, 2655, 15040, 5016, 19913, 8717, 47432, 3660, 38637, 2304, 25720, 9122, 3555, 48923, 20666, 1863, 9381, 29538, 28239, 47432, 3660, 6024, 104, 2304, 25720, 33251, 3555, 48923, 20666, 1863, 9381, 39894, 3615, 3555, 2288, 14739, 3224, 41850, 25961, 2655, 18871, 16254, 6225, 9957, 3660, 4032, 7435, 3555, 2655, 9122, 2655, 21136, 37983, 4032, 33599, 2655, 17082, 1211, 2655, 29538, 18863, 9957, 3660, 5551, 4117, 2655, 2288, 9154, 3714, 25720], "avg_logprob": -0.14406780279793982, "compression_ratio": 2.06, "no_speech_prob": 1.1920928955078125e-07, "words": 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"probability": 0.65478515625}, {"start": 2001.82, "end": 2002.02, "word": " عن", "probability": 0.99462890625}, {"start": 2002.02, "end": 2002.78, "word": " أقل", "probability": 0.9954427083333334}, {"start": 2002.78, "end": 2003.4, "word": " كمية", "probability": 0.99560546875}, {"start": 2003.4, "end": 2003.62, "word": " من", "probability": 0.98876953125}, {"start": 2003.62, "end": 2003.82, "word": " الـ", "probability": 0.657958984375}, {"start": 2003.82, "end": 2004.36, "word": " analyte", "probability": 0.8271484375}, {"start": 2004.36, "end": 2005.08, "word": " موجودة", "probability": 0.9813232421875}, {"start": 2005.08, "end": 2006.14, "word": " بالعينة", "probability": 0.9312744140625}, {"start": 2006.14, "end": 2006.64, "word": " هذا", "probability": 0.708984375}, {"start": 2006.64, "end": 2007.2, "word": " التعريف", "probability": 0.9832763671875}, {"start": 2007.2, "end": 2007.58, "word": " كلنا", "probability": 0.93505859375}, {"start": 2007.58, "end": 2008.28, "word": " 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ويكشفلي عن الأشخاص المصابين بالمرض أيضًا تعريف آخر لـ sensitivity هي ال ability to exclude الـ false negative قدرة الـ kit إنه يكشفلي أو إنه يستثنيلي الأشخاص", "tokens": [6027, 5016, 3794, 32277, 10632, 39896, 6225, 3555, 9640, 3660, 18871, 3485, 281, 8944, 5876, 2423, 39184, 2609, 365, 4752, 12174, 3215, 25720, 2423, 39184, 8260, 36145, 3224, 7251, 2304, 1829, 11622, 20292, 4032, 1829, 4117, 8592, 5172, 20292, 18871, 16247, 8592, 9778, 33546, 9673, 9381, 16758, 9957, 20666, 29973, 11242, 36632, 11242, 14111, 995, 37279, 16572, 5172, 19753, 34740, 5296, 39184, 19392, 39896, 2423, 3485, 281, 33536, 2423, 39184, 7908, 3671, 12174, 3215, 25720, 2423, 39184, 8260, 36145, 3224, 7251, 4117, 8592, 5172, 20292, 34051, 36145, 3224, 7251, 14851, 12984, 22653, 20292, 16247, 8592, 9778, 33546], "avg_logprob": -0.1417410715806241, "compression_ratio": 1.6551724137931034, "no_speech_prob": 0.0206451416015625, "words": [{"start": 2012.75, "end": 2013.67, "word": "الحساسية", "probability": 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"end": 2037.23, "word": " الـ", "probability": 0.815673828125}, {"start": 2037.23, "end": 2037.39, "word": " kit", "probability": 0.9326171875}, {"start": 2037.39, "end": 2037.81, "word": " إنه", "probability": 0.94140625}, {"start": 2037.81, "end": 2038.45, "word": " يكشفلي", "probability": 0.98896484375}, {"start": 2038.45, "end": 2039.43, "word": " أو", "probability": 0.97412109375}, {"start": 2039.43, "end": 2039.85, "word": " إنه", "probability": 0.952392578125}, {"start": 2039.85, "end": 2041.01, "word": " يستثنيلي", "probability": 0.9232421875}, {"start": 2041.01, "end": 2042.39, "word": " الأشخاص", "probability": 0.9964599609375}], "temperature": 1.0}, {"id": 93, "seek": 206467, "start": 2042.73, "end": 2064.67, "text": "اللي هما Exclude يستثنى الأشخاص الـ False Negative يعني اللي هما أصلا حقيقة عندهم المرض لكن لسبب ما طلعت نتيجتهم False Negative اللي هو الـ Negative الكاذب إذا قانون الـ Sensitivity أخدناه كلنا بالإحصاء", "tokens": [6027, 20292, 8032, 15042, 9368, 32334, 7251, 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"end": 2062.03, "word": " قانون", "probability": 0.9763997395833334}, {"start": 2062.03, "end": 2062.37, "word": " الـ", "probability": 0.694091796875}, {"start": 2062.37, "end": 2062.95, "word": " Sensitivity", "probability": 0.7827962239583334}, {"start": 2062.95, "end": 2063.63, "word": " أخدناه", "probability": 0.93203125}, {"start": 2063.63, "end": 2063.93, "word": " كلنا", "probability": 0.9287109375}, {"start": 2063.93, "end": 2064.67, "word": " بالإحصاء", "probability": 0.82001953125}], "temperature": 1.0}, {"id": 94, "seek": 209326, "start": 2065.84, "end": 2093.26, "text": "الـ number of true positive على الـ number of true positive زائد الـ number of false negative true positive على true positive زائد false negative هذا القانون اللي مطلوب معناه أما لـ specificity التخصصية هي عبارة عن detect the desired analyte without interferences قدرة الـ CAT", "tokens": [6027, 39184, 1230, 295, 2074, 3353, 15844, 2423, 39184, 1230, 295, 2074, 3353, 30767, 16373, 3215, 2423, 39184, 1230, 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2083.52, "end": 2083.84, "word": " أما", "probability": 0.83154296875}, {"start": 2083.84, "end": 2084.0, "word": " لـ", "probability": 0.7149658203125}, {"start": 2084.0, "end": 2084.86, "word": " specificity", "probability": 0.810302734375}, {"start": 2084.86, "end": 2086.04, "word": " التخصصية", "probability": 0.96943359375}, {"start": 2086.04, "end": 2086.3, "word": " هي", "probability": 0.85107421875}, {"start": 2086.3, "end": 2086.88, "word": " عبارة", "probability": 0.9964599609375}, {"start": 2086.88, "end": 2087.14, "word": " عن", "probability": 0.99560546875}, {"start": 2087.14, "end": 2087.88, "word": " detect", "probability": 0.875}, {"start": 2087.88, "end": 2088.34, "word": " the", "probability": 0.89990234375}, {"start": 2088.34, "end": 2089.02, "word": " desired", "probability": 0.93408203125}, {"start": 2089.02, "end": 2089.82, "word": " analyte", "probability": 0.887939453125}, {"start": 2089.82, "end": 2090.48, "word": " without", "probability": 0.9287109375}, {"start": 2090.48, "end": 2091.78, "word": " interferences", "probability": 0.85400390625}, {"start": 2091.78, "end": 2092.46, "word": " قدرة", "probability": 0.9680989583333334}, {"start": 2092.46, "end": 2093.02, "word": " الـ", "probability": 0.80517578125}, {"start": 2093.02, "end": 2093.26, "word": " CAT", "probability": 0.4462890625}], "temperature": 1.0}, {"id": 95, "seek": 211681, "start": 2094.27, "end": 2116.81, "text": "أو الفحص إنه يتفاعل مع الـ Analyte المطلوب قياسها من غير ما يتفاعل مع Analyte أخرى أنا ما بدي أقيسها مثلا أنا كت السكر يفترض الـ Reagent تبع السكر المستخدم في الفحص يتفعلي فقط مع السكر الموجود بعينة المريض", "tokens": [10721, 2407, 27188, 5016, 9381, 36145, 3224, 7251, 2655, 5172, 995, 30241, 20449, 2423, 39184, 1107, 5222, 975, 9673, 9566, 1211, 37746, 12174, 25528, 3794, 11296, 9154, 32771, 13546, 19446, 7251, 2655, 5172, 995, 30241, 20449, 1107, 5222, 975, 5551, 34740, 7578, 41850, 19446, 4724, 16254, 5551, 38436, 3794, 11296, 50113, 15040, 41850, 9122, 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{"start": 2098.59, "end": 2099.45, "word": " المطلوب", "probability": 0.9652099609375}, {"start": 2099.45, "end": 2100.21, "word": " قياسها", "probability": 0.89892578125}, {"start": 2100.21, "end": 2100.69, "word": " من", "probability": 0.85986328125}, {"start": 2100.69, "end": 2101.03, "word": " غير", "probability": 0.996337890625}, {"start": 2101.03, "end": 2101.21, "word": " ما", "probability": 0.9736328125}, {"start": 2101.21, "end": 2102.01, "word": " يتفاعل", "probability": 0.96279296875}, {"start": 2102.01, "end": 2102.41, "word": " مع", "probability": 0.9814453125}, {"start": 2102.41, "end": 2103.05, "word": " Analyte", "probability": 0.7685546875}, {"start": 2103.05, "end": 2103.59, "word": " أخرى", "probability": 0.9803059895833334}, {"start": 2103.59, "end": 2103.87, "word": " أنا", "probability": 0.94189453125}, {"start": 2103.87, "end": 2104.07, "word": " ما", "probability": 0.9482421875}, {"start": 2104.07, "end": 2104.49, "word": " بدي", "probability": 0.75390625}, 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"probability": 0.991943359375}, {"start": 2356.66, "end": 2357.82, "word": " المكونات،", "probability": 0.9462890625}, {"start": 2357.82, "end": 2357.96, "word": " a", "probability": 0.818359375}, {"start": 2357.96, "end": 2358.46, "word": " solution", "probability": 0.962890625}, {"start": 2358.46, "end": 2358.8, "word": " that", "probability": 0.9306640625}, {"start": 2358.8, "end": 2359.54, "word": " contains", "probability": 0.8662109375}], "temperature": 1.0}, {"id": 108, "seek": 238488, "start": 2360.32, "end": 2384.88, "text": "the same constituent نفس المكونات as those being analyzed in the patient sample وعادة بيجيني مع الشركة وبتيجي معاها ورقة هذه الورقة فيها الـnormal range مثلا السكر من 70 ل110 milligram per deciliter فيه range للانالايت اللي أنا بدي أجيسها أما الـstandard", "tokens": [3322, 912, 16085, 317, 8717, 36178, 9673, 4117, 2407, 8315, 2655, 382, 729, 885, 28181, 294, 264, 4537, 6889, 4032, 3615, 18513, 3660, 4724, 1829, 7435, 9957, 1829, 20449, 25124, 31747, 3660, 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2369.62, "end": 2370.04, "word": " معاها", "probability": 0.828125}, {"start": 2370.04, "end": 2370.58, "word": " ورقة", "probability": 0.9482421875}, {"start": 2370.58, "end": 2371.06, "word": " هذه", "probability": 0.8486328125}, {"start": 2371.06, "end": 2371.42, "word": " الورقة", "probability": 0.9371744791666666}, {"start": 2371.42, "end": 2371.78, "word": " فيها", "probability": 0.974365234375}, {"start": 2371.78, "end": 2372.46, "word": " الـnormal", "probability": 0.5244954427083334}, {"start": 2372.46, "end": 2373.3, "word": " range", "probability": 0.9267578125}, {"start": 2373.3, "end": 2373.7, "word": " مثلا", "probability": 0.938720703125}, {"start": 2373.7, "end": 2374.14, "word": " السكر", "probability": 0.871337890625}, {"start": 2374.14, "end": 2374.32, "word": " من", "probability": 0.90673828125}, {"start": 2374.32, "end": 2374.66, "word": " 70", "probability": 0.7373046875}, {"start": 2374.66, "end": 2375.3, "word": " ل110", "probability": 0.754150390625}, {"start": 2375.3, "end": 2376.16, "word": " milligram", "probability": 0.69189453125}, {"start": 2376.16, "end": 2376.48, "word": " per", "probability": 0.943359375}, {"start": 2376.48, "end": 2377.18, "word": " deciliter", "probability": 0.806640625}, {"start": 2377.18, "end": 2377.6, "word": " فيه", "probability": 0.809326171875}, {"start": 2377.6, "end": 2378.08, "word": " range", "probability": 0.91259765625}, {"start": 2378.08, "end": 2381.92, "word": " للانالايت", "probability": 0.6676025390625}, {"start": 2381.92, "end": 2382.3, "word": " اللي", "probability": 0.90673828125}, {"start": 2382.3, "end": 2382.48, "word": " أنا", "probability": 0.57958984375}, {"start": 2382.48, "end": 2382.76, "word": " بدي", "probability": 0.745361328125}, {"start": 2382.76, "end": 2383.28, "word": " أجيسها", "probability": 0.8287109375}, {"start": 2383.28, "end": 2383.92, "word": " أما", "probability": 0.933349609375}, {"start": 2383.92, "end": 2384.88, "word": " الـstandard", "probability": 0.58721923828125}], "temperature": 1.0}, {"id": 109, "seek": 239612, "start": 2386.34, "end": 2396.12, "text": "عبارة عن substance of constant composition and of sufficient purity to be used for comparison purpose", "tokens": [3615, 3555, 9640, 3660, 18871, 12961, 295, 5754, 12686, 293, 295, 11563, 34382, 281, 312, 1143, 337, 9660, 4334], "avg_logprob": -0.15556640028953553, "compression_ratio": 1.1368421052631579, "no_speech_prob": 0.0, "words": [{"start": 2386.34, "end": 2387.3, "word": "عبارة", "probability": 0.955322265625}, {"start": 2387.3, "end": 2387.52, "word": " عن", "probability": 0.99365234375}, {"start": 2387.52, "end": 2388.26, "word": " substance", "probability": 0.25244140625}, {"start": 2388.26, "end": 2388.7, "word": " of", "probability": 0.96142578125}, {"start": 2388.7, "end": 2389.48, "word": " constant", "probability": 0.9287109375}, {"start": 2389.48, "end": 2390.34, "word": " composition", "probability": 0.94482421875}, {"start": 2390.34, "end": 2391.2, "word": " and", "probability": 0.646484375}, {"start": 2391.2, "end": 2391.62, "word": " of", "probability": 0.93017578125}, {"start": 2391.62, "end": 2392.38, "word": " sufficient", "probability": 0.865234375}, {"start": 2392.38, "end": 2393.1, "word": " purity", "probability": 0.974609375}, {"start": 2393.1, "end": 2393.38, "word": " to", "probability": 0.95654296875}, {"start": 2393.38, "end": 2393.58, "word": " be", "probability": 0.97314453125}, {"start": 2393.58, "end": 2393.94, "word": " used", "probability": 0.93310546875}, {"start": 2393.94, "end": 2394.24, "word": " for", "probability": 0.9677734375}, {"start": 2394.24, "end": 2395.0, "word": " comparison", "probability": 0.82763671875}, {"start": 2395.0, "end": 2396.12, "word": " purpose", "probability": 0.7294921875}], "temperature": 1.0}, {"id": 110, "seek": 242141, "start": 2396.97, "end": 2421.41, "text": "الـ Standard عبارة عن محلول يحتوي على مادة واحدة substance واحدة، مادة واحدة هذه المادة لها constant composition يعني لها exact concentration لها تركيز معين مثلًا، الـ Kit تبع السكر بيجي مع الـ Standard هذا الـ Standard جوا محلول جواة السكر", "tokens": [6027, 39184, 21298, 6225, 3555, 9640, 3660, 18871, 3714, 5016, 1211, 12610, 7251, 33753, 45865, 15844, 3714, 18513, 3660, 36764, 24401, 3660, 12961, 36764, 24401, 3660, 12399, 3714, 18513, 3660, 36764, 24401, 3660, 29538, 9673, 18513, 3660, 5296, 11296, 5754, 12686, 37495, 22653, 5296, 11296, 1900, 9856, 5296, 11296, 6055, 31747, 1829, 11622, 20449, 9957, 50113, 1211, 14111, 995, 12399, 2423, 39184, 23037, 6055, 3555, 3615, 21136, 37983, 4724, 1829, 7435, 1829, 20449, 2423, 39184, 21298, 23758, 2423, 39184, 21298, 10874, 14407, 3714, 5016, 1211, 12610, 10874, 14407, 3660, 21136, 37983], "avg_logprob": -0.1824048859593661, "compression_ratio": 1.7990196078431373, "no_speech_prob": 0.0, "words": [{"start": 2396.97, "end": 2397.39, "word": "الـ", "probability": 0.97705078125}, {"start": 2397.39, "end": 2397.85, "word": " Standard", "probability": 0.71875}, 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2414.59, "word": " مثلًا،", "probability": 0.74208984375}, {"start": 2414.59, "end": 2414.81, "word": " الـ", "probability": 0.699951171875}, {"start": 2414.81, "end": 2414.99, "word": " Kit", "probability": 0.1702880859375}, {"start": 2414.99, "end": 2415.29, "word": " تبع", "probability": 0.8125}, {"start": 2415.29, "end": 2415.89, "word": " السكر", "probability": 0.90869140625}, {"start": 2415.89, "end": 2416.55, "word": " بيجي", "probability": 0.9549560546875}, {"start": 2416.55, "end": 2416.69, "word": " مع", "probability": 0.9921875}, {"start": 2416.69, "end": 2417.03, "word": " الـ", "probability": 0.59912109375}, {"start": 2417.03, "end": 2417.51, "word": " Standard", "probability": 0.8896484375}, {"start": 2417.51, "end": 2418.03, "word": " هذا", "probability": 0.75244140625}, {"start": 2418.03, "end": 2418.37, "word": " الـ", "probability": 0.966064453125}, {"start": 2418.37, "end": 2418.79, "word": " Standard", "probability": 0.921875}, {"start": 2418.79, "end": 2419.45, "word": " جوا", "probability": 0.704833984375}, {"start": 2419.45, "end": 2420.23, "word": " محلول", "probability": 0.84942626953125}, {"start": 2420.23, "end": 2420.85, "word": " جواة", "probability": 0.7206217447916666}, {"start": 2420.85, "end": 2421.41, "word": " السكر", "probability": 0.94970703125}], "temperature": 1.0}, {"id": 111, "seek": 244171, "start": 2422.3, "end": 2441.72, "text": "بيكون موجود جوات السكر وهذا السكر بيكون له تركيز معين ويستخدم الـ Standard من أجل معرفة تركيز عينة unknown عينة مجهولة، هذا اشتغلته في سنة تانية لما عملته فحص السكر", "tokens": [3555, 1829, 30544, 3714, 29245, 23328, 10874, 2407, 9307, 21136, 37983, 37037, 15730, 21136, 37983, 4724, 1829, 30544, 46740, 6055, 31747, 1829, 11622, 20449, 9957, 4032, 1829, 14851, 9778, 40448, 2423, 39184, 21298, 9154, 5551, 7435, 1211, 20449, 28480, 3660, 6055, 31747, 1829, 11622, 6225, 9957, 3660, 9841, 6225, 9957, 3660, 3714, 7435, 3224, 12610, 3660, 12399, 23758, 1975, 8592, 2655, 17082, 1211, 47395, 8978, 8608, 1863, 3660, 6055, 7649, 10632, 5296, 15042, 6225, 42213, 47395, 6156, 5016, 9381, 21136, 37983], "avg_logprob": -0.16291920404608656, "compression_ratio": 1.6136363636363635, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 2422.3, "end": 2422.82, "word": "بيكون", "probability": 0.7643229166666666}, {"start": 2422.82, "end": 2423.3, "word": " موجود", "probability": 0.9773763020833334}, {"start": 2423.3, "end": 2423.78, "word": " جوات", "probability": 0.5355631510416666}, {"start": 2423.78, "end": 2424.34, "word": " السكر", "probability": 0.824951171875}, {"start": 2424.34, "end": 2425.22, "word": " وهذا", "probability": 0.67431640625}, {"start": 2425.22, "end": 2425.68, "word": " السكر", "probability": 0.974365234375}, {"start": 2425.68, "end": 2426.12, "word": " بيكون", "probability": 0.9342447916666666}, {"start": 2426.12, "end": 2426.46, "word": " له", "probability": 0.73388671875}, {"start": 2426.46, "end": 2427.22, "word": " تركيز", "probability": 0.9671630859375}, 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"الـ Interpretation of Quality Control Charts طبعاً بدنا نحكي معلومة أنه أنا مثلا كمختبر أو كمستشفى كل يوم قبل ما أشبك عينات المرضى على الجهاز لازم أشتغل control أجيب عينات control أعملها فحص السكر وفحص البروتين وكل الفحصات أطلبلها كل الفحصات على الجهاز", "tokens": [6027, 39184, 5751, 6629, 399, 295, 28892, 12912, 761, 11814, 23032, 3555, 3615, 995, 14111, 47525, 8315, 8717, 5016, 4117, 1829, 20449, 1211, 20498, 3660, 14739, 3224, 41850, 50113, 15040, 9122, 2304, 46456, 26890, 34051, 9122, 2304, 14851, 8592, 5172, 7578, 28242, 7251, 20498, 12174, 36150, 19446, 5551, 8592, 3555, 4117, 6225, 1829, 8315, 2655, 9673, 43042, 7578, 15844, 25724, 3224, 31377, 5296, 31377, 2304, 5551, 8592, 2655, 17082, 1211, 1969, 5551, 7435, 1829, 3555, 6225, 1829, 8315, 2655, 1969, 5551, 25957, 1211, 11296, 6156, 5016, 9381, 21136, 37983, 4032, 5172, 5016, 9381, 2423, 26890, 35473, 9957, 4032, 28820, 27188, 5016, 9381, 9307, 5551, 9566, 46152, 1211, 11296, 28242, 27188, 5016, 9381, 9307, 15844, 25724, 3224, 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258121, "start": 2554.94, "end": 2581.22, "text": "عشان أنا بدي أعمل Interpretation بدي أعمل تحليل لنتائج ال control اللي أنا بشبكها كل يوم لأن هذا واجب واجب ومطلوب منها لأن مثلا وزارة الصحة تتيجي حملة تفتيش على المختبر كل شهر كل شهر بتبقى ترسميه chart ترسميه شكل تمثل فيه نتائج ال control اللي طلعت معك", "tokens": [3615, 8592, 7649, 41850, 4724, 16254, 5551, 25957, 1211, 5751, 6629, 399, 4724, 16254, 5551, 25957, 1211, 6055, 5016, 20292, 1211, 5296, 29399, 16373, 7435, 2423, 1969, 13672, 1829, 41850, 4724, 8592, 3555, 4117, 11296, 28242, 7251, 20498, 5296, 33456, 23758, 4032, 26108, 3555, 4032, 26108, 3555, 4032, 2304, 9566, 1211, 37746, 9154, 11296, 5296, 33456, 50113, 15040, 4032, 11622, 9640, 3660, 31767, 5016, 3660, 6055, 31371, 7435, 1829, 11331, 2304, 37977, 6055, 5172, 31371, 8592, 15844, 9673, 46456, 26890, 28242, 13412, 3224, 2288, 28242, 13412, 3224, 2288, 39894, 3555, 4587, 7578, 6055, 2288, 38251, 1829, 3224, 6927, 6055, 2288, 38251, 1829, 3224, 13412, 28820, 46811, 12984, 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Control Chart» بخص نتائج الـ Control وهذا المنحنى هو الـ most widely used technique هو الأكثر انتشارا واستخداما لعنا منحنيات أخرى بس هو الأكتر استخداما الكلام اللي تحت محكيه هذا احنا هنحكيه على الرسمة بالـ Slider التانية", "tokens": [1211, 15042, 6055, 9778, 1211, 9381, 1829, 39894, 7435, 2304, 3615, 1829, 8717, 2655, 16373, 7435, 2423, 39184, 12912, 50113, 15040, 5296, 5172, 5016, 9381, 21136, 37983, 46599, 2655, 32887, 5016, 6055, 2288, 38251, 1829, 11296, 15844, 9154, 5016, 1863, 7578, 23758, 9673, 1863, 5016, 1863, 7578, 24525, 2304, 3224, 4657, 11020, 11869, 12, 41, 2213, 12912, 49762, 5933, 4724, 9778, 9381, 8717, 2655, 16373, 7435, 2423, 39184, 12912, 37037, 15730, 9673, 1863, 5016, 1863, 7578, 31439, 2423, 39184, 881, 13371, 1143, 6532, 31439, 16247, 4117, 49115, 16472, 2655, 8592, 9640, 995, 4032, 995, 14851, 9778, 3215, 10943, 995, 5296, 3615, 8315, 9154, 5016, 22653, 9307, 5551, 34740, 7578, 4724, 3794, 31439, 16247, 4117, 2655, 2288, 44713, 9778, 3215, 10943, 995, 2423, 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"seek": 265275, "start": 2629.21, "end": 2652.75, "text": "هذا اللي أمامنا هو الـ Levigenance Chart هذا الـ Chart المنحنة وهذه النتائج هي نتائج لفحص السكر على مدار 20 يوم على الـ X-axis هذا المنحنة لازم أحط الأيام اليوم الأول، اليوم التاني، تلاتة، أربعة، خمسة، ستة، لحد اليوم العشرين", "tokens": [3224, 15730, 13672, 1829, 5551, 2304, 10943, 8315, 31439, 2423, 39184, 1456, 85, 3213, 719, 49762, 23758, 2423, 39184, 49762, 9673, 1863, 5016, 1863, 3660, 37037, 24192, 28239, 2655, 16373, 7435, 39896, 8717, 2655, 16373, 7435, 5296, 5172, 5016, 9381, 21136, 37983, 15844, 3714, 3215, 9640, 945, 7251, 20498, 15844, 2423, 39184, 1783, 12, 24633, 23758, 9673, 1863, 5016, 1863, 3660, 5296, 31377, 2304, 5551, 5016, 9566, 16247, 1829, 10943, 45595, 20498, 16247, 12610, 12399, 45595, 20498, 16712, 7649, 1829, 12399, 6055, 1211, 9307, 3660, 12399, 5551, 25513, 27884, 12399, 16490, 2304, 3794, 3660, 12399, 8608, 2655, 3660, 12399, 5296, 24401, 45595, 20498, 18863, 46309, 9957], "avg_logprob": 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{"start": 3034.33, "end": 3035.75, "word": " نتائج؟", "probability": 0.87998046875}, {"start": 3035.75, "end": 3036.09, "word": " زي", "probability": 0.919189453125}, {"start": 3036.09, "end": 3036.27, "word": " هنا", "probability": 0.97509765625}, {"start": 3036.27, "end": 3036.91, "word": " واحد،", "probability": 0.7154947916666666}, {"start": 3036.91, "end": 3037.19, "word": " تلت", "probability": 0.9827473958333334}, {"start": 3037.19, "end": 3037.51, "word": " أس", "probability": 0.71826171875}, {"start": 3037.51, "end": 3038.29, "word": " نتيجة", "probability": 0.881103515625}, {"start": 3038.29, "end": 3038.71, "word": " واحدة", "probability": 0.9814453125}, {"start": 3038.71, "end": 3038.83, "word": " من", "probability": 0.9921875}, {"start": 3038.83, "end": 3039.41, "word": " نتائج", "probability": 0.9964599609375}, {"start": 3039.41, "end": 3039.73, "word": " الـ", "probability": 0.977294921875}, {"start": 3039.73, "end": 3039.93, "word": " Control", "probability": 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الكلام", "probability": 0.90478515625}, {"start": 3044.29, "end": 3044.55, "word": " إيش", "probability": 0.68603515625}, {"start": 3044.55, "end": 3044.85, "word": " تلاتة", "probability": 0.857666015625}, {"start": 3044.85, "end": 3045.09, "word": " اسم", "probability": 0.740234375}, {"start": 3045.09, "end": 3045.35, "word": " هذا", "probability": 0.4091796875}, {"start": 3045.35, "end": 3045.81, "word": " الحدود", "probability": 0.9353841145833334}, {"start": 3045.81, "end": 3046.41, "word": " الإحصائي", "probability": 0.96455078125}, {"start": 3046.41, "end": 3046.99, "word": " تلاتة", "probability": 0.911865234375}, {"start": 3046.99, "end": 3047.51, "word": " standard", "probability": 0.5576171875}, {"start": 3047.51, "end": 3048.31, "word": " deviation", "probability": 0.9150390625}, {"start": 3048.31, "end": 3049.25, "word": " تمام؟", "probability": 0.8935546875}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 3050.289375, "duration_after_vad": 3002.9731249999923}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/v_VgjVkzGH0_raw.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/v_VgjVkzGH0_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..16aa459352b201eb6c2b244a14c3b3514c35769b
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/v_VgjVkzGH0_raw.srt
@@ -0,0 +1,2432 @@
+1
+00:00:01,210 --> 00:00:04,850
+السلام عليكم ورحمة الله وبركاته يعطيكم العافية
+
+2
+00:00:04,850 --> 00:00:09,150
+جميعا ان شاء الله اليوم محاضرتنا بعنوان quality
+
+3
+00:00:09,150 --> 00:00:15,280
+control مراقبة الجودةهنا بدنا نحكي عن الـ Quality
+
+4
+00:00:15,280 --> 00:00:21,360
+Assurance برنامج ضمان الجودة بدنا نتعرف أول إشي
+
+5
+00:00:21,360 --> 00:00:33,440
+على تعريف ضمان الجودة عبارة عن برنامج
+
+6
+00:00:33,440 --> 00:00:41,130
+ضمان الجودة هو عبارة عنمجموعة من الخطوات المترابطة
+
+7
+00:00:41,130 --> 00:00:48,050
+التي يجب على الـ Lab Technician يعني أخصاء التحليل
+
+8
+00:00:48,050 --> 00:00:54,890
+اتباعها من أجل إعطاء أفضل خدمةلـ patient و ال
+
+9
+00:00:54,890 --> 00:01:00,330
+physician أنا ك lab technician كخصائي تحليل كيف
+
+10
+00:01:00,330 --> 00:01:04,670
+أنا ممكن أقدم أفضل خدمة لل patient و ال physician
+
+11
+00:01:04,670 --> 00:01:11,230
+أفضل خدمة أقصد فيها إعطاء result صحيحة right
+
+12
+00:01:11,230 --> 00:01:17,100
+resultالـ patient يعني أنا بعمل التحليل واجبي أعطي
+
+13
+00:01:17,100 --> 00:01:22,540
+نتائج صحيحة right result للمريض و لل physician و
+
+14
+00:01:22,540 --> 00:01:28,780
+للدكتور عشان في الآخر الدكتور يعطي decision قرار
+
+15
+00:01:28,780 --> 00:01:33,160
+بي ل treatmentالـ Quality Assurance هذا برنامج
+
+16
+00:01:33,160 --> 00:01:38,000
+كبير is a complete system عبارة عن نظام معقد which
+
+17
+00:01:38,000 --> 00:01:44,620
+contain quality control كلنا بنسمع بـ مراقبة
+
+18
+00:01:44,620 --> 00:01:48,560
+الجودة مراقبة الجودة اللي هو الـ Quality Control
+
+19
+00:01:48,560 --> 00:01:54,600
+يعتبر جزء من برنامج ضمان الجودة اللي هو الـ
+
+20
+00:01:54,600 --> 00:01:57,500
+Quality Assurance الـ Quality Assurance هو
+
+21
+00:01:57,500 --> 00:02:04,330
+البرنامج الكبير اللي بيضمControl تعريف آخر للـ
+
+22
+00:02:04,330 --> 00:02:09,230
+Quality Assurance Right Result إعطاء نتائج صحيحة
+
+23
+00:02:10,090 --> 00:02:14,250
+تحليل صحيحة at right time بكفيش أنا أعطي نتيجة
+
+24
+00:02:14,250 --> 00:02:19,670
+صحيحة لازم أعطلها في الوقت المناسب يعني أطلع نتيجة
+
+25
+00:02:19,670 --> 00:02:24,850
+التحليل بسرعة ما ياخد معي التحليل وقت on right
+
+26
+00:02:24,850 --> 00:02:29,870
+specimen لما بدي أجي أشتغل على عينة صحيحة مجموعة
+
+27
+00:02:29,870 --> 00:02:35,090
+بطريقة صحيحة بـ Anticoagulant مطلوب مأخوذة من ال
+
+28
+00:02:35,090 --> 00:02:40,220
+right patientمن الـ Patient الصحيح اللي مطلوب له
+
+29
+00:02:40,220 --> 00:02:41,120
+التحليل
+
+30
+00:02:45,240 --> 00:02:48,360
+عرفنا الـ Quality Assurance اللي هو الـ Complete
+
+31
+00:02:48,360 --> 00:02:54,580
+System النظام الكامل المعقد اللذي يضم عدة برامج
+
+32
+00:02:54,580 --> 00:02:58,920
+طبعاً الـ GitHub عرف اللي هو الـ Quality Control
+
+33
+00:02:58,920 --> 00:03:02,860
+اللي هو جزء من الـ Quality Assurance الـ Quality
+
+34
+00:03:02,860 --> 00:03:07,720
+Control مراقبة الجودة هو عبارة عن الـ process of
+
+35
+00:03:07,720 --> 00:03:10,620
+monitoring the accuracy and precision of
+
+36
+00:03:10,620 --> 00:03:14,670
+laboratory tests with control samplesهو عبارة عن
+
+37
+00:03:14,670 --> 00:03:21,510
+عملية متابعة لصحة وضقة النتائج اللي بيطلعها
+
+38
+00:03:21,510 --> 00:03:28,330
+المختبر من خلال استخدام عينة Control أثناء أداء
+
+39
+00:03:28,330 --> 00:03:32,990
+الفحوصات هالجيت لو أنا بدي أجي جاني بشنق مريض بدي
+
+40
+00:03:32,990 --> 00:03:38,290
+يعني أعمله فحص سكر لازم أمشي مع عينته عينة Control
+
+41
+00:03:39,000 --> 00:03:42,220
+لو إجاني شخص بدي يعمل فحص الـ Total Protein أو
+
+42
+00:03:42,220 --> 00:03:48,300
+Enzyme أو أي test في الكيميا لازم أناشي control
+
+43
+00:03:48,300 --> 00:03:54,980
+إذن مراقبة الجودة هي عملية متابعة لمدى صحة وضقة
+
+44
+00:03:55,350 --> 00:04:01,150
+النتائج اللي بيطلعها المختبر من خلال استخدام يعني
+
+45
+00:04:01,150 --> 00:04:07,710
+أنا بشيك على صحة ونتائج على صحة وضقة النتائج اللي
+
+46
+00:04:07,710 --> 00:04:16,160
+بيطلعها المختبر من خلال اني بمشي عينة controlبمشي
+
+47
+00:04:16,160 --> 00:04:22,580
+عينة control مع شغلي عشان أشيك على شغله تعريف آخر
+
+48
+00:04:22,580 --> 00:04:26,580
+للـ Quality Control الـ statistical process used
+
+49
+00:04:26,580 --> 00:04:30,460
+to monitor and evaluate analytical process that
+
+50
+00:04:30,460 --> 00:04:35,820
+produces patient results هي عبارة عن عملية إحصائية
+
+51
+00:04:36,380 --> 00:04:41,480
+عادة أنا بستخدم الـ Quality Control مراقبة الجودة
+
+52
+00:04:41,480 --> 00:04:48,320
+من أجل متابعة and تقييم من أجل المتابعة وتقييم
+
+53
+00:04:48,320 --> 00:04:53,820
+العملية التحليلية أثناء تحليل الفحص That produces
+
+54
+00:04:53,820 --> 00:05:00,150
+the patient resultsاللي هي أثناء العملية التحليلية
+
+55
+00:05:00,150 --> 00:05:05,690
+اللي بدي تم من خلالها إعطاء نتائج لـ patient نتيجة
+
+56
+00:05:05,690 --> 00:05:10,490
+التحليل إذا بدي أفهم من التعريف إنه الـ Quality
+
+57
+00:05:10,490 --> 00:05:15,730
+Control يتم تطبيقهأثناء أو في مرحلة الـ Analytical
+
+58
+00:05:15,730 --> 00:05:18,750
+phase إحنا المرحلة التحليلية تقسم لتلت أقسام
+
+59
+00:05:18,750 --> 00:05:23,970
+Analytical، Pre Analytical و Analytical and Post
+
+60
+00:05:23,970 --> 00:05:27,050
+Analytical ما قبل التحليل، أثناء التحليل، بعد
+
+61
+00:05:27,050 --> 00:05:31,970
+التحليل برنامج مراقبة الجودة يتم تطبيقه في الـ
+
+62
+00:05:31,970 --> 00:05:35,690
+Analytical process في عملية التحليل أنا أثناء مبجر
+
+63
+00:05:35,690 --> 00:05:41,090
+الفحص بمشي مع عينة control عشان أشيك على نتائج ال
+
+64
+00:05:41,090 --> 00:05:46,380
+patient butالـ Quality Assurance البرنامج الكبير
+
+65
+00:05:46,380 --> 00:05:52,740
+هذا البرنامج يتم تطبيقه في الثلاث مراحل عشان هيك
+
+66
+00:05:52,740 --> 00:05:57,020
+هو برنامج شامل كامل يتم تطبيقه في الـ Pre
+
+67
+00:05:57,020 --> 00:06:00,620
+-analytical والـ Analytical والـ Post-analytical
+
+68
+00:06:00,620 --> 00:06:06,110
+لأن البرنامج الكبير مجموعة خطوات مترابطةلو أنا
+
+69
+00:06:06,110 --> 00:06:11,230
+كـLab Technician اتبعت برنامج ضمان الجودة من أول
+
+70
+00:06:11,230 --> 00:06:15,490
+ما استلمت العينة لحد ما سجلت النتيجة مش هنجع في
+
+71
+00:06:15,490 --> 00:06:19,150
+الخطأ الـQuality Control يتم تطبيقه في الـ
+
+72
+00:06:19,150 --> 00:06:22,730
+Analytical Phase أما الـQuality Assurance بتتم
+
+73
+00:06:22,730 --> 00:06:26,270
+تطبيقه في التلت مراحل في الـPre Analytical،
+
+74
+00:06:26,270 --> 00:06:29,780
+Analytical، Post Analyticalبتلاقي وزارة الصحة
+
+75
+00:06:29,780 --> 00:06:34,300
+شركات بتحطلك بروتوكولات معينة لقالي تجمع العينة
+
+76
+00:06:34,300 --> 00:06:38,100
+أثناء التحليل أيضا ما بعد التحليل لما تيجي تسجل
+
+77
+00:06:38,100 --> 00:06:42,440
+العينة وتخرجيها، اذا هذا كله برنامج كامل يعني
+
+78
+00:06:42,440 --> 00:06:47,540
+الهدف منه بتطلع نتيجة صحيحةبدنا نحكي عن الـ
+
+79
+00:06:47,540 --> 00:06:50,640
+Quality Control Types أنواع الـ Quality Control
+
+80
+00:06:50,640 --> 00:06:54,260
+نوعين اللي هو الـ Internal Quality Control مراقبة
+
+81
+00:06:54,260 --> 00:06:57,920
+جودة داخلية والـ External Quality Control مراقبة
+
+82
+00:06:57,920 --> 00:07:02,020
+جودة خارجية بالبداية الـ Internal Quality Control
+
+83
+00:07:02,020 --> 00:07:05,980
+شو تعريفها؟ is a procedure for utilizing the
+
+84
+00:07:05,980 --> 00:07:10,280
+results of only one laboratory for quality control
+
+85
+00:07:10,280 --> 00:07:16,820
+purposeهو عبارة عن إجراء لاستخدام نتائج مختبر واحد
+
+86
+00:07:16,820 --> 00:07:24,440
+فقط لغرض مراقبة الجودة بمفهوم أبسط من هيكالـ
+
+87
+00:07:24,440 --> 00:07:28,220
+Internal Quality Control معناه أنا كمختبر أو
+
+88
+00:07:28,220 --> 00:07:34,420
+كمستشفة لازم كل يوم مع فحوصاتي أمشي عينة الـ
+
+89
+00:07:34,420 --> 00:07:37,720
+control مع نتائج ال patient يعني إجاني مريض بدي
+
+90
+00:07:37,720 --> 00:07:41,600
+يفحص السكر بدي أمشي بدي أمشي مع فحص السكر control
+
+91
+00:07:41,600 --> 00:07:44,720
+بدي أفحص الـ total protein بدي أمشي مع الـ total
+
+92
+00:07:44,720 --> 00:07:49,180
+protein control هذا ال control عادة بيجي من الشركة
+
+93
+00:07:49,180 --> 00:07:53,790
+إما powder أو liquid سائدوبيكون معاه أيضًا ورقة
+
+94
+00:07:53,790 --> 00:07:59,710
+بانفلة فيها الـ Normal Range لكل فحص السكر مثلًا
+
+95
+00:07:59,710 --> 00:08:03,830
+من 70 ل110 Total Protein من 6 ل 8 gram per
+
+96
+00:08:03,830 --> 00:08:08,250
+deciliter بيكون مكتوب فيه الـ Range لجميع الفحصات
+
+97
+00:08:08,250 --> 00:08:12,630
+أنا عليا كل يوم أمشي مع عينات ال patient عينات ال
+
+98
+00:08:12,630 --> 00:08:16,230
+control هذا بسميه Internal Quality Control بيكون
+
+99
+00:08:16,230 --> 00:08:20,910
+على نطاق one laboratory على نطاق المختبر الواحد
+
+100
+00:08:20,910 --> 00:08:25,810
+butالـ External Quality Control مراقبة الجودة
+
+101
+00:08:25,810 --> 00:08:30,150
+الخارجية هو إجراء إن عرفوا بالإنجليزي is a
+
+102
+00:08:30,150 --> 00:08:32,950
+procedure for utilizing for quality control
+
+103
+00:08:32,950 --> 00:08:36,950
+purposes the results of several laboratories which
+
+104
+00:08:36,950 --> 00:08:41,510
+analyze the same specimens several laboratories
+
+105
+00:08:41,510 --> 00:08:48,680
+إيش يعني؟هو عبارة عن إجراء لاستخدام نتائج أكثر من
+
+106
+00:08:48,680 --> 00:08:56,220
+مختبر فقط لغرض مراقبة الجودة إيش يعني الفرج إنه
+
+107
+00:08:56,220 --> 00:09:02,310
+فوق في الـ Internal على مستوى نطاق مختبر واحدالـ
+
+108
+00:09:02,310 --> 00:09:06,890
+External Quality Control مجموعة من المختبرات يعني
+
+109
+00:09:06,890 --> 00:09:10,730
+several laboratories بديوا يصير نظام منافسة مثلا
+
+110
+00:09:10,730 --> 00:09:15,450
+أكتر من مستشفى بتيجي وزارة الصحة أو شركات صحية
+
+111
+00:09:15,450 --> 00:09:21,630
+بتجيب عينات Control تمام؟ بتوزعها على المستشفيات
+
+112
+00:09:21,630 --> 00:09:27,220
+هذه عينات الـ Controlبتتعامل معها المستشفى كأنها
+
+113
+00:09:27,220 --> 00:09:32,800
+عينة unknown كأنها عينة مجهولة مش معروفة ومثلا
+
+114
+00:09:32,800 --> 00:09:37,980
+وزارة الصحة بتطلب من جميع المستشفيات ياخدوا هذه
+
+115
+00:09:37,980 --> 00:09:42,960
+العينة ويحللوها ويعملوا لها تحليل لمستوى السكر
+
+116
+00:09:42,960 --> 00:09:48,040
+بتحلل المستشفيات بتستخدم هذه العينة وبتطلع نتيجة
+
+117
+00:09:48,040 --> 00:09:53,930
+السكر وبتطبع النتيجة وبتسلمها لوزارة الصحةوزارة
+
+118
+00:09:53,930 --> 00:10:00,970
+الصحة بدها تشوف هل هذه المستشفى بتطلع نتائج سليمة
+
+119
+00:10:00,970 --> 00:10:04,790
+ولا لأ؟ هتطلع فيه مستشفيات هتطلع مستوى السكر صح،
+
+120
+00:10:04,790 --> 00:10:08,290
+فيه مستشفيات لأ ممكن يكون عندها خلل في الجهاز، في
+
+121
+00:10:08,290 --> 00:10:12,970
+الـreagent هنا مين بيعرف الـnormal range للسكر فقط
+
+122
+00:10:12,970 --> 00:10:18,720
+وزارة الصحة؟المستشفى ما بتكون عندها أي ورقة بالـ
+
+123
+00:10:18,720 --> 00:10:22,300
+Normal Range تبع الـ Control اللي جايبها وزارة
+
+124
+00:10:22,300 --> 00:10:26,820
+الصحة إذاً الـ External Quality Control ما هو إلا
+
+125
+00:10:26,820 --> 00:10:35,080
+نظام منافسةبين المستشفيات ومراقبة للمستشفيات من
+
+126
+00:10:35,080 --> 00:10:41,460
+قبل وزارة الصحة وشركات الصحية عساس لو المستشفى
+
+127
+00:10:41,460 --> 00:10:46,040
+طلعت نتيجة صحيحة أو مختبر طلع نتيجة صحيحة للعينة
+
+128
+00:10:46,040 --> 00:10:50,680
+المجهولة إذا هذا مختبر يعني معتمد بتصير وزارة
+
+129
+00:10:50,680 --> 00:10:54,640
+الصحة تعطيه accreditation، اعتمادودايمًا بشكروا
+
+130
+00:10:54,640 --> 00:10:57,960
+فيه إن مختبر بيطلع نتائج سليمة وصحيحة ليش لأن
+
+131
+00:10:57,960 --> 00:11:02,740
+وزارة الصحة عملت نظام اختبار للمستشفيات اختبرتهم
+
+132
+00:11:02,740 --> 00:11:08,460
+باعتقهم عينة control مش معروف ال normal range
+
+133
+00:11:08,460 --> 00:11:13,220
+للفحص اللي طلبته الصحة هذا ال external الخارجية
+
+134
+00:11:13,220 --> 00:11:19,220
+على مستوى أكتر من مختبر وأكتر من مستشفىwhen errors
+
+135
+00:11:19,220 --> 00:11:23,040
+occur متى تحدث الأخطاء errors occur when there is
+
+136
+00:11:23,040 --> 00:11:26,320
+a loss of accuracy and precision تحدث الأخطاء
+
+137
+00:11:26,320 --> 00:11:33,020
+عندما نفقد ال accuracy و ال precision صحة و دقة
+
+138
+00:11:33,020 --> 00:11:38,000
+النتائج لو تم فقدها معناه أكيد في عندي خطأ معناه
+
+139
+00:11:38,000 --> 00:11:44,280
+حدث خطأA primary goal of a quality assurance الهدف
+
+140
+00:11:44,280 --> 00:11:50,500
+الأساسي والأولي لبرنامج ضمان الجودة Is to reduce
+
+141
+00:11:50,500 --> 00:11:56,420
+and detect error تقليل وكشف الأخطاء يكشف عن الخطأ
+
+142
+00:11:56,420 --> 00:12:02,440
+ويبقى يقلل من هذا الخطأ Or to obtain the best
+
+143
+00:12:02,440 --> 00:12:05,920
+possible accuracy and precision أيضًا من هدف هذا
+
+144
+00:12:05,920 --> 00:12:14,020
+البرنامج تقديم أفضلصحة ودقة للنتيجة الـ Source of
+
+145
+00:12:14,020 --> 00:12:18,560
+Error مصادر الأخطاء All analytical results are
+
+146
+00:12:18,560 --> 00:12:22,720
+subject to errors arising from a variety of causes
+
+147
+00:12:22,720 --> 00:12:26,140
+but it's short kept to a minimum كل النتائج
+
+148
+00:12:26,140 --> 00:12:32,700
+التحليلية، كل الفحوصات في المختبر معرضة إن يصير
+
+149
+00:12:32,700 --> 00:12:39,280
+فيها أخطاءوهذه الأخطاء زي من أسباب مختلفة لكن أنا
+
+150
+00:12:39,280 --> 00:12:43,140
+ك lab technician بدي أحاول أقلل من حدوث هذه
+
+151
+00:12:43,140 --> 00:12:47,840
+الأخطاء ال errors can occur at various stages in
+
+152
+00:12:47,840 --> 00:12:54,670
+the process الأخطاء تحدثفي مراحل مختلفة من عملية
+
+153
+00:12:54,670 --> 00:12:58,790
+التحليل الأخطاء التحدث في الـ Pre-analytical phase
+
+154
+00:12:58,790 --> 00:13:02,110
+وفي الـ Analytical phase و ال Past Analytical
+
+155
+00:13:02,110 --> 00:13:05,770
+phase في الـ Pre-analytical phase يعني هذه أخطاء
+
+156
+00:13:05,770 --> 00:13:11,490
+تحدث outside the lab خارج المختبر أثناء جمع العينة
+
+157
+00:13:11,490 --> 00:13:15,990
+ال Analytical phase أخطاء تحدث within the lab يعني
+
+158
+00:13:15,990 --> 00:13:20,480
+أثناء التحليل أثناء عملية الفحصأما الـ Post
+
+159
+00:13:20,480 --> 00:13:25,340
+Analytical هذه عبارة عن Error بتحدث مابعد عملية
+
+160
+00:13:25,340 --> 00:13:30,100
+التحليل إيش ال Post Analytical الكاتب عندها؟ The
+
+161
+00:13:30,100 --> 00:13:33,700
+correct result is generated أنا مثلا بكون مطلعة
+
+162
+00:13:33,700 --> 00:13:38,640
+نتائج صحيحة و 100% but is incorrectly recordedin
+
+163
+00:13:38,640 --> 00:13:43,540
+the patient's record لكن المشكلة في عملية التسجيل
+
+164
+00:13:43,540 --> 00:13:47,420
+احنا عارفين معظم مشاكل ال post analytical ما بعد
+
+165
+00:13:47,420 --> 00:13:51,140
+التحليل عملية تسجيل النتيجة أنا بكون انطلع النتيجة
+
+166
+00:13:51,140 --> 00:13:56,620
+صح بس نجلاها في السجل أو بعتها للدكتور كتبها خطأ
+
+167
+00:13:56,620 --> 00:14:02,710
+دخلاها على ال lab خطأ تمام؟الـ True Analytical
+
+168
+00:14:02,710 --> 00:14:06,890
+Errors are those which occur during the actual
+
+169
+00:14:06,890 --> 00:14:09,850
+performance of the analysis which can be
+
+170
+00:14:09,850 --> 00:14:14,290
+classified into systematic error and random error
+
+171
+00:14:14,290 --> 00:14:19,550
+بيحكيلي الأخطاء التحليلية الحقيقية هي اللي بتحدث
+
+172
+00:14:19,550 --> 00:14:27,030
+أثناء العملية التحليلية أثناءالشغل الحقيقي الـ
+
+173
+00:14:27,030 --> 00:14:31,350
+Actual Performance الأداء الحقيقي للتحليل يعني
+
+174
+00:14:31,350 --> 00:14:36,590
+أثناء ما أنت بتحلل العينة هذه أخطاء حقيقية جوهرية
+
+175
+00:14:36,590 --> 00:14:41,350
+أثناء التحليل اللي بتحدث وتقسم الأخطاء إلى قسمين
+
+176
+00:14:41,350 --> 00:14:46,610
+Systematic Error خطأ منهجي and Random Error خطأ
+
+177
+00:14:46,610 --> 00:14:52,450
+عشوائيالـ Systematic Errors الخطأ المنهجي on
+
+178
+00:14:52,450 --> 00:14:56,330
+repeated analysis of the sample we may also find
+
+179
+00:14:56,330 --> 00:15:00,570
+values at wrong level too high or too low بحكي
+
+180
+00:15:00,570 --> 00:15:04,490
+للخطأ المنهجي بدي أتعرف عليه كيف لو جبتي عينة
+
+181
+00:15:04,490 --> 00:15:10,820
+controlواشتغلتي لها فحص السكر وطلعتي نتيجتها وبعد
+
+182
+00:15:10,820 --> 00:15:14,360
+ساعة قعدت الفحص كمان مرة اشتغلتي لها فحص السكر
+
+183
+00:15:14,360 --> 00:15:18,560
+وسجلت النتيجة بعد ساعة قعدت الفحص كمان مرة اذا
+
+184
+00:15:18,560 --> 00:15:22,600
+تعملي repeated analysis مثلا فحصت عينة ال control
+
+185
+00:15:22,600 --> 00:15:28,270
+عشر مرات عملتلها فحص السكر خلال اليوملو شغلي تمام
+
+186
+00:15:28,270 --> 00:15:33,850
+ووضعي كله تمام يفترض العشر نتائج اللي طلعوا يكونوا
+
+187
+00:15:33,850 --> 00:15:36,910
+جراب من بعض مثلا بحدود السبعينات، سبعين، خمسة
+
+188
+00:15:36,910 --> 00:15:41,110
+وسبعين، تلاتة وسبعين، تسعة وسبعين لكن في العشر
+
+189
+00:15:41,110 --> 00:15:45,790
+نتائج اللي طلعوالو لجتما النتائج صحيحة إجراب من
+
+190
+00:15:45,790 --> 00:15:51,810
+بعض ونتشتين كانوا يعني wrong value قيم خاطئا بينين
+
+191
+00:15:51,810 --> 00:15:56,550
+كتير بعاد عن النتائج اللي طلعت يعني لو طلعت نتشتين
+
+192
+00:15:56,550 --> 00:16:01,920
+أو أكتر ابعاد عن نتائجي معناه فيه مشكلةمعناه في
+
+193
+00:16:01,920 --> 00:16:07,100
+خطأ منهجي نتيجتين أو أكتر فيهم مشكلة معناه في عندي
+
+194
+00:16:07,100 --> 00:16:11,940
+خطأ منهجي ممكن يطلع هذه النتائج أو هذه النتائج
+
+195
+00:16:11,940 --> 00:16:15,820
+الخاطئة اللي طلعت بعيدة ممكن تكون too high، كتير
+
+196
+00:16:15,820 --> 00:16:20,420
+عالية مثلا يطلع السكر 200، 300 أو too low يطلع
+
+197
+00:16:20,420 --> 00:16:25,500
+السكر 40، 20، 10 والعينة بدنا نتفج أنها طبيعية
+
+198
+00:16:25,500 --> 00:16:33,480
+سكرها من 70 ل110وعملت فحص السكر لعينة control عشر
+
+199
+00:16:33,480 --> 00:16:39,680
+مرات تم النتائج صحيحة ونتجتين طلعوا كتير بعد سواء
+
+200
+00:16:39,680 --> 00:16:44,440
+عليين أو واطين معناه في عندي systematic error خطأ
+
+201
+00:16:44,440 --> 00:16:49,410
+منهجينWhich can be due to قد تكون أسبابه
+
+202
+00:16:49,410 --> 00:16:53,150
+analytical method مشكلة في طريقة التحليل أو ال
+
+203
+00:16:53,150 --> 00:16:57,830
+technical performance في أداء أخصاء التحليل في
+
+204
+00:16:57,830 --> 00:17:01,390
+طريقة شغله مشكلة في ال reagent مشكلة في ال
+
+205
+00:17:01,390 --> 00:17:04,430
+measuring equipment في المعدات المستخدمة في
+
+206
+00:17:04,430 --> 00:17:08,630
+التحليل و بالأخص ال bybitمشكلة بالـ Technicians
+
+207
+00:17:08,630 --> 00:17:13,010
+نفسه تبع التحليل أخصاء التحليل There are two types
+
+208
+00:17:13,010 --> 00:17:16,370
+of systematic errors عندي نوعين لـ systematic
+
+209
+00:17:16,370 --> 00:17:21,990
+error خطأ ثابت وخطأ متناسب constant error ثابت و
+
+210
+00:17:21,990 --> 00:17:26,130
+الخطأ ال proportional error الخطأ المتناسب ال
+
+211
+00:17:26,130 --> 00:17:31,420
+constant error الخطأ الثابتإيش تعريفه؟ Error in a
+
+212
+00:17:31,420 --> 00:17:34,800
+test system in which the amount of error remains
+
+213
+00:17:34,800 --> 00:17:38,280
+constant throughout the range of the test process
+
+214
+00:17:38,280 --> 00:17:42,580
+هو عبارة عن الخطأ اللي بيصير أثناء عملية التحليل
+
+215
+00:17:42,580 --> 00:17:48,140
+ويبقى ثابت هذا الخطأ ال amount حجمه remains
+
+216
+00:17:48,140 --> 00:17:51,740
+constant عشان هيك سموه الخطأ الثابت حجم هذا الخطأ
+
+217
+00:17:51,740 --> 00:17:58,770
+يبقى ثابتمهما زاد تركيز الـ Analyte اللي أنا بدي
+
+218
+00:17:58,770 --> 00:18:04,050
+أجيسه في العينة لو كان السكر 70 أو كان السكر 80
+
+219
+00:18:04,050 --> 00:18:08,070
+اللي موجود في العينة أو كان السكر تركيزه 100 أو
+
+220
+00:18:08,070 --> 00:18:13,890
+200 أو 300 أو 600 هذا الـ Constant Error مهما زاد
+
+221
+00:18:13,890 --> 00:18:21,120
+تركيز الـ Analyte في العينةيبقى ثابت كما هو وما
+
+222
+00:18:21,120 --> 00:18:25,820
+بيتغير له نسبة ثابتة الـ Constant Error أما الـ
+
+223
+00:18:25,820 --> 00:18:30,520
+Proportional Error الخطأ المتناسب Error in a test
+
+224
+00:18:30,520 --> 00:18:35,500
+system in which the amount of error increases the
+
+225
+00:18:35,500 --> 00:18:39,620
+concentration of the substance being measured هو
+
+226
+00:18:39,620 --> 00:18:45,350
+عبارة عن الخطأ اللي بيصير أثناء عملية التحليلحجم
+
+227
+00:18:45,350 --> 00:18:53,030
+هذا الخطأ يزداد بزيادة تركيز الـ Analyte جوّات
+
+228
+00:18:53,030 --> 00:18:57,430
+العينة إذا الفرق بينه وبين الـ Constant Error إن
+
+229
+00:18:57,430 --> 00:19:01,830
+الـ Proportional Error هذا الخطأ المتناسب ما بيظل
+
+230
+00:19:01,830 --> 00:19:07,870
+ثابت بيزداد حجم هذا الخطأ كل ما زاد تركيز مثلا الـ
+
+231
+00:19:07,870 --> 00:19:11,350
+Analyte اللي هو مثلا السكر اللي موجود في العينة
+
+232
+00:19:11,350 --> 00:19:17,110
+مثلا لو إيجتني عينة سكرها 70الها نسبة خطأ معينة
+
+233
+00:19:17,110 --> 00:19:23,250
+طيب لو زودت تركيز السكر خليته 200 نسبة الخطأ هتزيد
+
+234
+00:19:23,250 --> 00:19:29,730
+إذا نسبة الخطأ تزداد بزيادة تركيز الانالايت اللي
+
+235
+00:19:29,730 --> 00:19:37,140
+أنا بدي أجيسه داخل العينةلو جينا برجع بعيد نفس
+
+236
+00:19:37,140 --> 00:19:41,000
+الكلام بحكي عن الـTypes of Systematic Error عن
+
+237
+00:19:41,000 --> 00:19:44,760
+أنواع الخطأ المنهج حكينا Proportional Error خطأ
+
+238
+00:19:44,760 --> 00:19:49,000
+متناسب and Constant Error وخطأ ثابت بالنسبة
+
+239
+00:19:49,000 --> 00:19:53,320
+لـProportional Error في كمان تعريف لهThe magnitude
+
+240
+00:19:53,320 --> 00:19:57,520
+of the error grows with the concentration of the
+
+241
+00:19:57,520 --> 00:20:03,100
+material being measured هو الخطأ اللي بيزداد تزداد
+
+242
+00:20:03,100 --> 00:20:08,860
+نسبته بزيادة تركيز الانالايت اللي موجود في العينة
+
+243
+00:20:08,860 --> 00:20:13,160
+زي ما احنا شايفين بالرسم الأولى بتعبر عن ال
+
+244
+00:20:13,160 --> 00:20:19,350
+proportional error في عندى علاقة ترضية مابيننسبة
+
+245
+00:20:19,350 --> 00:20:24,010
+الخطأ اللي بتسير وما بين تركيز الانالايت اللي أنا
+
+246
+00:20:24,010 --> 00:20:29,250
+بجيسه جواه العينة كل ما مثلا مكان تركيز السكر أكتر
+
+247
+00:20:29,250 --> 00:20:34,410
+كل ما زاد حجم الخطأ أما لما أحكيلك constant error
+
+248
+00:20:34,410 --> 00:20:39,390
+العكس يعني هذا الخطأ الثابت the magnitude of the
+
+249
+00:20:39,390 --> 00:20:43,450
+error remains the same through the range or
+
+250
+00:20:43,450 --> 00:20:47,520
+concentration of the material being measuredهو
+
+251
+00:20:47,520 --> 00:20:54,140
+الخطأ الذي يبقى ثابت مهما زاد تركيز الـ Analyte
+
+252
+00:20:54,140 --> 00:20:58,620
+جواه العينة يعني مهما اختلف مستوى السكر جواه
+
+253
+00:20:58,620 --> 00:21:04,560
+العينة بيظل هذا الخطأ الثابت له نسبة معينة مثلا
+
+254
+00:21:04,560 --> 00:21:12,150
+بحكيلك نسبة الخطأ لفحص السكر مثلا 10% خلاصبتظلها
+
+255
+00:21:12,150 --> 00:21:16,990
+الـ 10% هذه ثابتة هذا بيسموه constant error مهما
+
+256
+00:21:16,990 --> 00:21:21,830
+ذات تركيز السكر فيه العينة والرسمة التانية اللي هي
+
+257
+00:21:21,830 --> 00:21:25,350
+بتمثل الـ constant error
+
+258
+00:21:27,760 --> 00:21:31,520
+أما بالنسبة لـ Random Errors الأخطاء العشوائية
+
+259
+00:21:31,520 --> 00:21:35,420
+اشتعاريفها Errors are mistakes that occur without
+
+260
+00:21:35,420 --> 00:21:39,520
+prediction or regularity هي الأخطاء اللي بتصير من
+
+261
+00:21:39,520 --> 00:21:46,200
+غير أي تنبؤ أو انتظام يعني lab technician أخصاء
+
+262
+00:21:46,200 --> 00:21:51,240
+التحليل ما بتنبأ بالخطأ إنما يحدث الخطأ فجأة بشكل
+
+263
+00:21:51,240 --> 00:21:56,910
+عشوائيmanifest themselves by variations in the
+
+264
+00:21:56,910 --> 00:22:01,410
+results of repeated analyses of the same sample
+
+265
+00:22:01,410 --> 00:22:05,210
+either positive or negative errors are usually
+
+266
+00:22:05,210 --> 00:22:08,770
+distributed أيضًا هنا بيحكيلي بقدر أكشف الـ Random
+
+267
+00:22:08,770 --> 00:22:12,870
+error من خلال التحليل المستمر بجيب عينة control
+
+268
+00:22:12,870 --> 00:22:16,870
+وبفحصلها مستوى السكر بعد ساعة كمان وبعد ساعتين
+
+269
+00:22:16,870 --> 00:22:21,510
+مثلًا اشتغلت الفحث عشر مرات يفترض العشر نتائج تكون
+
+270
+00:22:21,510 --> 00:22:26,960
+متقاربةلكن لو طلعت 9 نتائج متقاربة ونتيجة واحدة هي
+
+271
+00:22:26,960 --> 00:22:30,720
+اللي فيها المشكلة فقط نتيجة واحدة بحكي أكيد هذا
+
+272
+00:22:30,720 --> 00:22:36,220
+خطأ random عشوائي فجأة حدث عندي خلل أدى إلى حدوث
+
+273
+00:22:36,220 --> 00:22:42,120
+تغير في هذه النتيجة إذا لو حدث عندي مشكلة بنتيجة
+
+274
+00:22:42,120 --> 00:22:47,640
+واحدة فقطأنا بحكي هنا في random error لكن نتيجتين
+
+275
+00:22:47,640 --> 00:22:53,340
+حدث فيهم خلل أو أكتر هذا systematic error these
+
+276
+00:22:53,340 --> 00:22:57,140
+variations may be caused by several variable
+
+277
+00:22:57,140 --> 00:23:01,220
+factors which include هنا في هذه العبارة بيحكي ليه
+
+278
+00:23:01,220 --> 00:23:06,020
+بكل بساطة أسباب ال random error ليش بيصير الخطأ
+
+279
+00:23:06,020 --> 00:23:12,460
+العشوائي أسبابهvariations in apparatus حدوث تذبذب
+
+280
+00:23:12,460 --> 00:23:16,440
+في شغل الـ apparatus اللي هي الأجهزة يقصد فيها
+
+281
+00:23:16,440 --> 00:23:21,460
+الأجهزة في المختبر مثلا عندنا جهاز الكيميا هذا
+
+282
+00:23:21,460 --> 00:23:25,540
+الجهاز بيعمل كل الفحوصات بدل ما نشتغلها يدويًا
+
+283
+00:23:25,540 --> 00:23:29,740
+manual بيشتغلها automated بيشتغل السكر البروتينات
+
+284
+00:23:29,740 --> 00:23:34,820
+الإنزيمات وكل حاجة هذا الجهاز من جوا فكرة عملهمثل
+
+285
+00:23:34,820 --> 00:23:39,760
+فكرة عمل لـ Spectrophotometer جواته فيه لمبة، هذه
+
+286
+00:23:39,760 --> 00:23:44,000
+اللمبة بتطلع ضوء، هذا الضوء بيروح بيدرب في العينة
+
+287
+00:23:44,000 --> 00:23:49,320
+تبعتنا، بخترق العينة وبيبدأ الانتصاص والجهاز
+
+288
+00:23:49,320 --> 00:23:54,940
+بيقرألي Absorbance، تمام؟لكن لو لفجأة حدث عندي
+
+289
+00:23:54,940 --> 00:23:59,580
+تذبذب في الجهاز يعني تذبذب في الطيار الكهربائي
+
+290
+00:23:59,580 --> 00:24:02,760
+اللي مشبوك فيه الجهاز الجهاز مشبوك على الكهربا
+
+291
+00:24:02,760 --> 00:24:09,100
+لفجأة ممكن الطيار الكهربائي يضعف لما بيدعف الشعاع
+
+292
+00:24:09,100 --> 00:24:13,050
+اللي بيطلع من اللمبة بيكون كتير ضعيفوحتى لو ضرب
+
+293
+00:24:13,050 --> 00:24:18,050
+بيه العينة تبعتي مش هيعطيني القراءة الصحيحة
+
+294
+00:24:18,050 --> 00:24:22,470
+وبالتالي النتيجة هتكون خاطئة إذا الطيار الكهربائي
+
+295
+00:24:22,470 --> 00:24:26,910
+لما بيدعف، بيدعف للحظة وبرجعي جوا عشان هيك هتلاحظ
+
+296
+00:24:26,910 --> 00:24:31,690
+لو عملتي فحص السكر لعشر مرات لعينة ال control في
+
+297
+00:24:31,690 --> 00:24:35,900
+كل المرات طلعت النتائج صحيحة ما عدا مرةهذا random
+
+298
+00:24:35,900 --> 00:24:41,180
+error بحكي ممكن ضعفت الكهربا على الجهاز فخلال ما
+
+299
+00:24:41,180 --> 00:24:45,580
+ضعفت أعطاني نتيجة خاطئة تمام أو variation في ال
+
+300
+00:24:45,580 --> 00:24:49,940
+temperature مثلا درجات الحرارة، ظروف التفاعل لو
+
+301
+00:24:49,940 --> 00:24:54,100
+اختلفت للحظة مثلا درجة الحرارة تحت الغرفة يفترض
+
+302
+00:24:54,100 --> 00:25:01,740
+تكون 22 ل 25 عليةوتيط هذا كله بيأثر على الفحوصات
+
+303
+00:25:01,740 --> 00:25:07,620
+اللي احنا بنشتغلها الـ weighting اللي هو الميزان
+
+304
+00:25:07,620 --> 00:25:13,380
+اللي بنستخدمه مثلا لوزن بعض الشغلات برضه في أجهزة
+
+305
+00:25:13,380 --> 00:25:17,740
+بتكون على الكهربا برضه مشكلة أو تذبذب في الكهربا
+
+306
+00:25:17,740 --> 00:25:21,460
+هيعمل عندنا مشكلة ويعطينا نتائج خاطئة الـ Random
+
+307
+00:25:21,460 --> 00:25:24,830
+error cannot be avoided للأسفالأخطاء العشوائية ما
+
+308
+00:25:24,830 --> 00:25:29,410
+بقدر أتجنبها يعني أنا بحاول أقلل منها بس دايما
+
+309
+00:25:29,410 --> 00:25:33,290
+اتجيني فجأة خلاف الـ Systematic Errors Systematic
+
+310
+00:25:33,290 --> 00:25:37,610
+Error بقدر يعني avoided يعني بقدر أني أتجنبها
+
+311
+00:25:37,610 --> 00:25:42,150
+these random errors can be reduced أنا ممكن أقلل
+
+312
+00:25:42,150 --> 00:25:46,460
+من حدوث الـ Random Errorby more precise method and
+
+313
+00:25:46,460 --> 00:25:51,340
+more accurate equipment إن أختار معدات وأجهزة وطرق
+
+314
+00:25:51,340 --> 00:25:56,310
+تحليل تكون صحيحة ودقيقةهنا بدنا نحكي عن الـ method
+
+315
+00:25:56,310 --> 00:26:00,650
+validation التأكد من صحة الطريقة المستخدمة في
+
+316
+00:26:00,650 --> 00:26:06,770
+التحليل أو تقييم الطريقة أو تقييم الـ kit الجديد
+
+317
+00:26:06,770 --> 00:26:11,770
+اللي بدنا نشتريه من الشركة المصنعة أنا كمختبر خاص
+
+318
+00:26:11,770 --> 00:26:17,050
+بشتغل مثلا فحص السكر بدي كتات للسكر كت السكر عبارة
+
+319
+00:26:17,050 --> 00:26:21,330
+عن شو؟ بكون فيه الـ reagent الـ standard الخاص
+
+320
+00:26:21,330 --> 00:26:25,940
+بالسكرهذا من وين، مين بيصنعه؟ بتصنعه الشركة عادة
+
+321
+00:26:25,940 --> 00:26:30,160
+أنا لما أروح أجيب هذا الـKit غلط أجيبه من الشركة
+
+322
+00:26:30,160 --> 00:26:34,600
+وبسرعة أروح أستخدمه وأعمل فيه فحوصات وأطلع نتائج
+
+323
+00:26:34,600 --> 00:26:41,260
+لناس يجب قبل استخدام الـKit أشيك على خمس شغلات في
+
+324
+00:26:41,260 --> 00:26:45,340
+الـKit، بدي أشيك على الـAccuracyالصحة وعلى
+
+325
+00:26:45,340 --> 00:26:49,000
+الـPrecision الدقة وعلى الـSensitivity الحساسية
+
+326
+00:26:49,000 --> 00:26:53,640
+وعلى الـSpecificity التخصصية وعلى الـLinearity
+
+327
+00:26:53,640 --> 00:26:58,440
+الخطية يعني خمس شغلات بتاخدها بعين الاعتبار عند
+
+328
+00:26:58,440 --> 00:27:03,620
+شراء أي كت جديد لأي فحص أول إشي الـAccuracy
+
+329
+00:27:03,620 --> 00:27:08,260
+الصحةThe measure of correctness or truth of
+
+330
+00:27:08,260 --> 00:27:15,300
+laboratory test هي عبارة عنقياس القيمة الحقيقية
+
+331
+00:27:15,300 --> 00:27:21,360
+للفحص هذه الـ accuracy الصحة يعني .. يعني جداش انت
+
+332
+00:27:21,360 --> 00:27:25,380
+.. يعني جداش هذا الـ kit بيعطيني و هذا الـ reagent
+
+333
+00:27:25,380 --> 00:27:29,080
+و المواد تعطيني نتيجة صحيحة يعني لو أنا استخدمت
+
+334
+00:27:29,080 --> 00:27:33,420
+الـ kit و استخدمت الـ reagent تبع السكر جداش هذا
+
+335
+00:27:33,420 --> 00:27:38,660
+الـ reagent بيعطيني صحة في النتائجهذا معنى الـ
+
+336
+00:27:38,660 --> 00:27:45,900
+Accuracy هي عبارة عن قياس القيمة الحقيقية للفحص زي
+
+337
+00:27:45,900 --> 00:27:52,700
+ما احنا شايفين وين جاي السهم؟ جاي السهم Target لو
+
+338
+00:27:52,700 --> 00:27:58,890
+كان الـ Kit تبعنابقيص مستوى السكر target معناه هذا
+
+339
+00:27:58,890 --> 00:28:02,630
+المطلوب معناه هذا الـ kick ممتاز هذا الـ reagent
+
+340
+00:28:02,630 --> 00:28:08,390
+100% كويس لأنه بيجيس ليه القيمة target بقطين
+
+341
+00:28:08,390 --> 00:28:13,950
+القيمة الحقيقيةتمام الـ Accuracy إلها تعريف آخر مش
+
+342
+00:28:13,950 --> 00:28:18,670
+موجود عندنا هتاخدوه بالنظر مع الدكتور مازن هو
+
+343
+00:28:18,670 --> 00:28:25,270
+عبارة عن مدى قرب القيمة المقاسة من القيمة الحقيقية
+
+344
+00:28:25,810 --> 00:28:29,290
+القيمة المقاسة اللي أنا جستها بالـ KET القيمة
+
+345
+00:28:29,290 --> 00:28:34,530
+الحقيقية هي القيمة اللي أصلا شركة مثلا لما بتجيبلك
+
+346
+00:28:34,530 --> 00:28:38,130
+Control تعطيك الـ Normal Range للسكر تبعه فالجيت
+
+347
+00:28:38,130 --> 00:28:41,890
+لو أنا استخدمت الـ Control هذا وجستله السكر بالـ
+
+348
+00:28:41,890 --> 00:28:47,730
+KET وطلع نتيجةالنتيجة اللي أنا طلعتها دي قيمة
+
+349
+00:28:47,730 --> 00:28:52,890
+مقاسة فمدى قرب القيمة المقاسة اللي أنا طلعتها من
+
+350
+00:28:52,890 --> 00:28:57,190
+القيمة الحقيقية اللي طلعتها الشركة هذا بنسميه الـ
+
+351
+00:28:57,190 --> 00:29:00,170
+Accuracy يعني لو كانت القيمة اللي أنا جيستها سبعين
+
+352
+00:29:00,170 --> 00:29:04,870
+وقيمة الشركة اللي طلعتها الشركة سبعين اتنين وسبعين
+
+353
+00:29:04,870 --> 00:29:09,540
+معناها هذا الـ kit ممتاز انه بطلع نتائج كويسةالـ
+
+354
+00:29:09,540 --> 00:29:14,100
+Precision اللي هي مدى الإحكام الـ Agreement
+
+355
+00:29:14,100 --> 00:29:19,120
+between replicate measurement مدى التوافق بين
+
+356
+00:29:19,120 --> 00:29:24,360
+النتائج اللي طلعت نتيجة الـ replication إعادة
+
+357
+00:29:24,360 --> 00:29:29,280
+الفحص هنا مفهوم الـ Precision حكيتلكم إيه الـ Jeep
+
+358
+00:29:29,280 --> 00:29:34,490
+Controlهذا الـ Control أعمله فحص السكر أكتر من مرة
+
+359
+00:29:34,490 --> 00:29:40,710
+عشر مرات مدى قرب النتائج من بعضها البعض هذا بنسمي
+
+360
+00:29:40,710 --> 00:29:44,990
+precision والله هذا ال kit more precise أنا جبت كت
+
+361
+00:29:44,990 --> 00:29:50,290
+جديد وجبت عينة وحلمت هذه العينة بهذا ال kit عشر
+
+362
+00:29:50,290 --> 00:29:54,250
+مرات والنتائج مثلا عملت فحص السكر النتائج كانت
+
+363
+00:29:54,250 --> 00:29:58,930
+كلها متقاربة من بعض تقارب النتائج من بعض هذا بنسمي
+
+364
+00:29:58,930 --> 00:30:04,100
+precisionالتقارب، الإحكام أو بيسموه الـ
+
+365
+00:30:04,100 --> 00:30:06,940
+Reproducibility معناه إنت إيش يعني
+
+366
+00:30:06,940 --> 00:30:11,080
+Reproducibility؟ لما تعمل إعادة للفحص أكتر من مرة
+
+367
+00:30:11,080 --> 00:30:16,260
+هتلاقي النتائج هي نفسها متقاربة هي عندنا أكتر من
+
+368
+00:30:16,260 --> 00:30:20,560
+سهم، عملت الفحص أكتر من مرة يعني عندي أكتر من سهم
+
+369
+00:30:20,560 --> 00:30:24,720
+وكل الأسهم زي ما إحنا شايفين متقاربة معناه فيه
+
+370
+00:30:24,720 --> 00:30:30,680
+precision عالي، عندنا إحكام عاليلو إيجينا للرسمة
+
+371
+00:30:30,680 --> 00:30:33,880
+اللي أمامنا خلينا نتطلع في الرسمتين اللي فوق
+
+372
+00:30:33,880 --> 00:30:39,060
+بالأول الرسمة اللي على اليمين هتلاحظ نقطة ثمرة
+
+373
+00:30:39,060 --> 00:30:42,620
+كبيرة بالنص هذه النقطة الثمرة الكبيرة بالنص بتعبر
+
+374
+00:30:42,620 --> 00:30:49,300
+أنه أنا كانت عندي عينة وجبت كت السكر واشتغلت هذه
+
+375
+00:30:49,300 --> 00:30:54,660
+العينة أكتر من مرةفحص السكر وطلع عندى مجموعة نتائج
+
+376
+00:30:54,660 --> 00:31:00,500
+هذه النتائج كلها متراكمة وكلها جانب بعض اتكومت
+
+377
+00:31:00,500 --> 00:31:06,020
+وانحطت بالنص معناه هذا الـ kit عنده high precision
+
+378
+00:31:06,020 --> 00:31:10,100
+ايش يعني high precision ان النتائج متقاربة كتير من
+
+379
+00:31:10,100 --> 00:31:13,560
+بعض لو انت عدت الفحص اكتر من مرة النتائج متقاربة
+
+380
+00:31:13,560 --> 00:31:18,900
+وhigh accuracy يعني عندى صحة كل النتائج اجت بالنص
+
+381
+00:31:18,900 --> 00:31:24,630
+اجت target تمام؟أما الرسم اللي فوق اللي على اليسار
+
+382
+00:31:24,630 --> 00:31:29,650
+لو لاحظتي أنه عندي مجموعة نتائج متكومة تمام نقطة
+
+383
+00:31:29,650 --> 00:31:35,030
+سمرة متكومة ومحتوطين تمام بيحكيلك high precision
+
+384
+00:31:35,030 --> 00:31:39,410
+okay نتائج متقاربة من بعضها البعد معناه في عندي
+
+385
+00:31:39,410 --> 00:31:45,150
+precision لكن لا accuracy هذا الكت مافي صح ليش؟
+
+386
+00:31:45,150 --> 00:31:50,600
+لأنه النتائج ماوجعت في ال targetالـ Target عنده
+
+387
+00:31:50,600 --> 00:31:56,120
+بالنص أو الدائرة الحمرا هذه target لكن تجعب برا لأ
+
+388
+00:31:56,120 --> 00:32:02,180
+بتكون فقدت الصحة تعالوا نشوف اليسار تحت الرسمتين
+
+389
+00:32:02,180 --> 00:32:04,080
+اللي على اليسار تحت
+
+390
+00:32:08,030 --> 00:32:14,110
+الرسمتين اللي تحت، جهة اليمين، بتلاحظ فيه نتائج
+
+391
+00:32:14,110 --> 00:32:18,790
+متفرقة عن بعضها البعض، مش متكومة مع بعضها البعض،
+
+392
+00:32:18,790 --> 00:32:23,290
+النتائج متفرقة، معناه مافي precision، مافي توافق
+
+393
+00:32:23,290 --> 00:32:29,050
+بينها، مافي تقاربلكن فيه high accuracy في صحة يعني
+
+394
+00:32:29,050 --> 00:32:33,510
+في صحة معناها okay جربت من ال target okay مش جوة
+
+395
+00:32:33,510 --> 00:32:38,050
+في المتصف الدائرة البيضة لجوة okay لكن جريبة شويه
+
+396
+00:32:38,050 --> 00:32:43,850
+من ال targetأما الرسمة اللي تحت على الآخر جهة
+
+397
+00:32:43,850 --> 00:32:49,930
+اليسار بيحكيلي لو انتوا لاحظتوا النقاط نقاط متبعدة
+
+398
+00:32:49,930 --> 00:32:54,030
+جدا يعني low precision مافي تقارب أيضا low
+
+399
+00:32:54,030 --> 00:32:58,930
+accuracy برضه مافي صحة لأنها بعيدة جدا عن الهدف
+
+400
+00:32:58,930 --> 00:33:06,160
+وعن الدائرة اللي في المنتصفخلّصنا من الـ accuracy
+
+401
+00:33:06,160 --> 00:33:08,460
+و الـ precision خلّينا نشوف الـ sensitivity
+
+402
+00:33:08,460 --> 00:33:13,040
+الحساسية كلنا عارفين إيش يعني حساسية الـ kit the
+
+403
+00:33:13,040 --> 00:33:16,300
+ability of a diagnostic test to detect very small
+
+404
+00:33:16,300 --> 00:33:21,140
+amounts of the analyte قدرة الفحص أو الـ kit إنه
+
+405
+00:33:21,140 --> 00:33:26,140
+يكشف ليه عن أقل كمية من الـ analyte موجودة بالعينة
+
+406
+00:33:26,140 --> 00:33:30,460
+هذا التعريف كلنا عارفينه في تعريف آخر برضه أنتوا
+
+407
+00:33:30,460 --> 00:33:34,690
+عارفينه أخدته في الإحصاءالحساسية هي عبارة عن
+
+408
+00:33:34,690 --> 00:33:39,230
+ability to correctly identify الـ individual with
+
+409
+00:33:39,230 --> 00:33:45,570
+disease قدرة الـ kit إنه يميزلي ويكشفلي عن الأشخاص
+
+410
+00:33:45,570 --> 00:33:52,050
+المصابين بالمرض أيضًا تعريف آخر لـ sensitivity هي
+
+411
+00:33:52,050 --> 00:33:57,230
+ال ability to exclude الـ false negative قدرة الـ
+
+412
+00:33:57,230 --> 00:34:03,910
+kit إنه يكشفلي أو إنه يستثنيلي الأشخاصاللي هما
+
+413
+00:34:03,910 --> 00:34:08,350
+Exclude يستثنى الأشخاص الـ False Negative يعني
+
+414
+00:34:08,350 --> 00:34:16,130
+اللي هما أصلا حقيقة عندهم المرض لكن لسبب ما طلعت
+
+415
+00:34:16,130 --> 00:34:19,670
+نتيجتهم False Negative اللي هو الـ Negative الكاذب
+
+416
+00:34:19,670 --> 00:34:26,220
+إذا قانون الـ Sensitivity أخدناه كلنا بالإحصاءالـ
+
+417
+00:34:26,220 --> 00:34:30,160
+number of true positive على الـ number of true
+
+418
+00:34:30,160 --> 00:34:34,960
+positive زائد الـ number of false negative true
+
+419
+00:34:34,960 --> 00:34:39,800
+positive على true positive زائد false negative هذا
+
+420
+00:34:39,800 --> 00:34:44,860
+القانون اللي مطلوب معناه أما لـ specificity
+
+421
+00:34:44,860 --> 00:34:49,820
+التخصصية هي عبارة عن detect the desired analyte
+
+422
+00:34:49,820 --> 00:34:56,050
+without interferences قدرة الـ CATأو الفحص إنه
+
+423
+00:34:56,050 --> 00:35:01,210
+يتفاعل مع الـ Analyte المطلوب قياسها من غير ما
+
+424
+00:35:01,210 --> 00:35:06,290
+يتفاعل مع Analyte أخرى أنا ما بدي أقيسها مثلا أنا
+
+425
+00:35:06,290 --> 00:35:10,870
+كت السكر يفترض الـ Reagent تبع السكر المستخدم في
+
+426
+00:35:10,870 --> 00:35:16,810
+الفحص يتفعلي فقط مع السكر الموجود بعينة المريض
+
+427
+00:35:16,950 --> 00:35:21,170
+وممنوع يتفاعل مع أي analyte أخرى، مع أي مادة أخرى،
+
+428
+00:35:21,170 --> 00:35:23,770
+ممنوع يتفاعل مع الـ Total Protein، ممنوع يتفاعل مع
+
+429
+00:35:23,770 --> 00:35:29,430
+أنزماء، تمام؟أو تعريف آخر الـ ability to correctly
+
+430
+00:35:29,430 --> 00:35:33,850
+identify individual without disease قدرة الفحص أنه
+
+431
+00:35:33,850 --> 00:35:38,870
+يميزلي الناس اللي ما بتعاني من أمراض اللي هم ال
+
+432
+00:35:38,870 --> 00:35:43,390
+true negative اللي عن جد أصحى أو تعريف آخر ال
+
+433
+00:35:43,390 --> 00:35:46,870
+ability to occlude ال false positive قدرة الفحص
+
+434
+00:35:46,870 --> 00:35:51,990
+أنه يستفنى الناس ال false positive اللي هم أصلا ما
+
+435
+00:35:51,990 --> 00:35:58,220
+عندهم حقيقة ما عندهم المرض لكن لسببما الفحص طلّع
+
+436
+00:35:58,220 --> 00:36:03,320
+نتيجتهم إن عندهم المرض بشكل كاذب إذن قانون
+
+437
+00:36:03,320 --> 00:36:08,240
+specificity عدد الأشخاص الأصحاء الـ number of true
+
+438
+00:36:08,240 --> 00:36:11,540
+negative على الـ number of true negative زائد الـ
+
+439
+00:36:11,540 --> 00:36:15,850
+number of false positiveهذا الجدول اللي أخدناه
+
+440
+00:36:15,850 --> 00:36:18,690
+بالإحصاء أهم إشي بس بدنا نعرف قانوني الـ
+
+441
+00:36:18,690 --> 00:36:22,050
+sensitivity و ال specificity ال sensitivity true
+
+442
+00:36:22,050 --> 00:36:26,170
+positive تحت على ال true positive زائد false
+
+443
+00:36:26,170 --> 00:36:30,030
+negative أما ال specificity هو عبارة عن ال true
+
+444
+00:36:30,030 --> 00:36:33,970
+negative على ال true negative زائد false positive
+
+445
+00:36:34,950 --> 00:36:39,210
+الـ Linearity الخطية عبارة عن is the range over
+
+446
+00:36:39,210 --> 00:36:42,990
+which the analytical system exhibits a linear هو
+
+447
+00:36:42,990 --> 00:36:48,890
+النطاق الذي يظهر فيه النظام التحليلي خطيابمعنى
+
+448
+00:36:48,890 --> 00:36:54,770
+يعني بمعنى أبسط من هيك وكلنا عارفينه إن الخطية و
+
+449
+00:36:54,770 --> 00:36:59,430
+الـ linearity تبعت أي كت هو أعلى قيمة وأقل قيمة
+
+450
+00:36:59,430 --> 00:37:04,030
+يستطيع الـ kit قياسهم، إذا أعلى قيمة وأقل قيمة
+
+451
+00:37:04,030 --> 00:37:07,490
+يستطيع الـ kit قياسهم هذه الـ linearity، the
+
+452
+00:37:07,490 --> 00:37:12,100
+highest concentration can be detected، تمام؟يعني
+
+453
+00:37:12,100 --> 00:37:16,460
+مثلًا كل Kit له Linearity معينة مثلًا السكر بكتب
+
+454
+00:37:16,460 --> 00:37:21,220
+لك في ال pamphlet تبعته في الورقة أن هذا الـKit
+
+455
+00:37:21,220 --> 00:37:27,720
+بقدر يجيس السكر من 46 إلى 600 لو إجاني شخصسكره
+
+456
+00:37:27,720 --> 00:37:34,720
+أعلى من 600 أو أقل من 46 مش هيقدر هذا الـ Reagent
+
+457
+00:37:34,720 --> 00:37:39,420
+يتفاعل مع السكر اللي موجود بعينته ومش هيعطيني أي
+
+458
+00:37:39,420 --> 00:37:43,740
+نتيجة هذه فكرة الـ Linearity مين بيقيصها، بتقيصها
+
+459
+00:37:43,740 --> 00:37:49,120
+الشركةThe measured value from a series of samples
+
+460
+00:37:49,120 --> 00:37:53,820
+solution is linearly proportional to the actual
+
+461
+00:37:53,820 --> 00:37:58,120
+concentration or content of the analyte in the
+
+462
+00:37:58,120 --> 00:38:03,660
+sample solution هذا الكلام يعني هو شغل شركات أكتر
+
+463
+00:38:03,660 --> 00:38:09,160
+من أنه يعني احنا لازم نهتم فيهعند الرسم اللي فوق
+
+464
+00:38:09,160 --> 00:38:17,020
+هي شكل Linear هذا بتكون X-axis وY-axis على الـ X
+
+465
+00:38:17,020 --> 00:38:21,860
+-axis تحت بحطوا الـ actual concentration التركيز
+
+466
+00:38:21,860 --> 00:38:26,220
+اللي من الشركة وعلى ال Y-axis بحطوا الـ measured
+
+467
+00:38:26,220 --> 00:38:30,820
+value القيم اللي أنا guessedها و الشركة بتمثل
+
+468
+00:38:30,820 --> 00:38:34,920
+العلاقة وهي اللي بتحسب الخطيئة فقط هذا اللي بدنا
+
+469
+00:38:34,920 --> 00:38:40,250
+نفهمهبدنا نفرق بين الـ Control و الـ Standard و
+
+470
+00:38:40,250 --> 00:38:43,870
+الـ Calibrator لإن كتير في ناس بتخلط بينهم الـ
+
+471
+00:38:43,870 --> 00:38:48,950
+Control هو عبارة عن محلول بيجينا من الشركة إما
+
+472
+00:38:48,950 --> 00:38:54,430
+Powder أو Liquid وعبارة عن solution محلول يحتوي
+
+473
+00:38:54,430 --> 00:39:01,000
+على نفس مكونات عينة المريضأصلا الـ control من وين
+
+474
+00:39:01,000 --> 00:39:05,740
+بيعملوا؟ من ناس الصحة أو من ناس مرضى، صح ولا لا،
+
+475
+00:39:05,740 --> 00:39:10,080
+سواء بيعملوا normal control أو abnormal control،
+
+476
+00:39:10,080 --> 00:39:14,740
+إذا مكونات الـ control هي نفس مكونات الدم تبع ال
+
+477
+00:39:14,740 --> 00:39:18,800
+patient، تبع المريض، نفس المكونات، a solution that
+
+478
+00:39:18,800 --> 00:39:24,680
+containsthe same constituent نفس المكونات as those
+
+479
+00:39:24,680 --> 00:39:28,400
+being analyzed in the patient sample وعادة بيجيني
+
+480
+00:39:28,400 --> 00:39:31,780
+مع الشركة وبتيجي معاها ورقة هذه الورقة فيها
+
+481
+00:39:31,780 --> 00:39:36,160
+الـnormal range مثلا السكر من 70 ل110 milligram
+
+482
+00:39:36,160 --> 00:39:41,920
+per deciliter فيه range للانالايت
+
+483
+00:39:41,920 --> 00:39:47,520
+اللي أنا بدي أجيسها أما الـstandardعبارة عن
+
+484
+00:39:47,520 --> 00:39:51,620
+substance of constant composition and of
+
+485
+00:39:51,620 --> 00:39:55,000
+sufficient purity to be used for comparison
+
+486
+00:39:55,000 --> 00:40:01,570
+purposeالـ Standard عبارة عن محلول يحتوي على مادة
+
+487
+00:40:01,570 --> 00:40:06,810
+واحدة substance واحدة، مادة واحدة هذه المادة لها
+
+488
+00:40:06,810 --> 00:40:10,850
+constant composition يعني لها exact concentration
+
+489
+00:40:10,850 --> 00:40:16,690
+لها تركيز معين مثلًا، الـ Kit تبع السكر بيجي مع
+
+490
+00:40:16,690 --> 00:40:21,410
+الـ Standard هذا الـ Standard جوا محلول جواة السكر
+
+491
+00:40:22,300 --> 00:40:27,220
+بيكون موجود جوات السكر وهذا السكر بيكون له تركيز
+
+492
+00:40:27,220 --> 00:40:36,340
+معين ويستخدم الـ Standard من أجل معرفة تركيز عينة
+
+493
+00:40:36,340 --> 00:40:40,620
+unknown عينة مجهولة، هذا اشتغلته في سنة تانية لما
+
+494
+00:40:40,620 --> 00:40:44,840
+عملته فحص السكركان عندكوا استخدمتوا standard السكر
+
+495
+00:40:44,840 --> 00:40:51,180
+لما بتستخدمي انت ال standard بتعرفي تركيز عينة ال
+
+496
+00:40:51,180 --> 00:40:56,290
+patient اللي هي ال unknown هذا الهدف منهمن خلال
+
+497
+00:40:56,290 --> 00:41:03,350
+معرفة تركيز الـ Standard بقدر أعرف تركيز السكر
+
+498
+00:41:03,350 --> 00:41:07,010
+اللي موجود في عينات الـ Patient طبعا الـ Standard
+
+499
+00:41:07,010 --> 00:41:11,190
+لأنه بيحتوي على مادة واحدة فالـ Purity تبعته
+
+500
+00:41:11,190 --> 00:41:15,080
+عالية، نقاطه عاليةأما الـCalibrator، Similar to
+
+501
+00:41:15,080 --> 00:41:20,040
+Standard هو نفس الـStandard بالظبط، لكن مش Pure،
+
+502
+00:41:20,040 --> 00:41:23,840
+مش نقي لأن الـCalibrator عادة بتكون من Multiple
+
+503
+00:41:23,840 --> 00:41:29,160
+Substance من أكتر من مادة الـCalibrator بتكون من
+
+504
+00:41:29,160 --> 00:41:32,820
+أكتر من مادة مع بعض، solution بيحتوي على أكتر من
+
+505
+00:41:32,820 --> 00:41:37,940
+مادة وكل مادة إلها Exact Concentration، إلها تركيز
+
+506
+00:41:37,940 --> 00:41:44,520
+معينالـ Interpretation of Quality Control Charts
+
+507
+00:41:44,520 --> 00:41:49,960
+طبعاً بدنا نحكي معلومة أنه أنا مثلا كمختبر أو
+
+508
+00:41:49,960 --> 00:41:55,980
+كمستشفى كل يوم قبل ما أشبك عينات المرضى على الجهاز
+
+509
+00:41:55,980 --> 00:42:01,680
+لازم أشتغل control أجيب عينات control أعملها فحص
+
+510
+00:42:01,680 --> 00:42:06,040
+السكر وفحص البروتين وكل الفحصات أطلبلها كل الفحصات
+
+511
+00:42:06,040 --> 00:42:11,910
+على الجهازوأشتغلها وأطلّع نتائجها وأشوف كيف نتائج
+
+512
+00:42:11,910 --> 00:42:15,850
+الـ Control بعد ما أتأكد إن نتائج الـ Control كلها
+
+513
+00:42:15,850 --> 00:42:21,610
+سليمة وصحيحة وبعطيني نتائج تمام بروح بقشبك عينات
+
+514
+00:42:21,610 --> 00:42:26,990
+المرضى على الجهاز وأنا مضطنة هلجيت نتائج الـ
+
+515
+00:42:26,990 --> 00:42:31,930
+Control اللي بتطلع هذه إحنا لازم نمثلها على الـ
+
+516
+00:42:31,930 --> 00:42:36,260
+Chart نمثلها على رسمةعشان أنا بدي أعمل
+
+517
+00:42:36,260 --> 00:42:40,660
+Interpretation بدي أعمل تحليل لنتائج ال control
+
+518
+00:42:40,660 --> 00:42:46,660
+اللي أنا بشبكها كل يوم لأن هذا واجب واجب ومطلوب
+
+519
+00:42:46,660 --> 00:42:50,320
+منها لأن مثلا وزارة الصحة تتيجي حملة تفتيش على
+
+520
+00:42:50,320 --> 00:42:56,580
+المختبر كل شهر كل شهر بتبقى ترسميه chart ترسميه
+
+521
+00:42:56,580 --> 00:43:01,770
+شكل تمثل فيه نتائج ال control اللي طلعت معكعلى
+
+522
+00:43:01,770 --> 00:43:06,350
+مدار الشهر مش احنا اتفجنا كل يوم بدك تشبك control
+
+523
+00:43:06,350 --> 00:43:11,250
+وتشتغلي عينة ال control جبل ما تبدأ تشتغلي عينة ال
+
+524
+00:43:11,250 --> 00:43:16,790
+patient على مدار التلاتين يوم بعد ما تخلصي اليوم
+
+525
+00:43:16,790 --> 00:43:21,880
+الأخر يوملما تخلصي بتجمعي نتائج الـ Control مثلا
+
+526
+00:43:21,880 --> 00:43:26,500
+لفحص السكر وبتروح ترسميها على منحنى هذا المنحنى
+
+527
+00:43:26,500 --> 00:43:31,980
+اسمه «Levy-Jones Control Chart» بخص نتائج الـ
+
+528
+00:43:31,980 --> 00:43:35,500
+Control وهذا المنحنى هو الـ most widely used
+
+529
+00:43:35,500 --> 00:43:39,680
+technique هو الأكثر انتشارا واستخداما لعنا منحنيات
+
+530
+00:43:39,680 --> 00:43:44,380
+أخرى بس هو الأكتر استخداما الكلام اللي تحت محكيه
+
+531
+00:43:44,380 --> 00:43:49,530
+هذا احنا هنحكيه على الرسمة بالـ Slider التانيةهذا
+
+532
+00:43:49,530 --> 00:43:53,630
+اللي أمامنا هو الـ Levigenance Chart هذا الـ Chart
+
+533
+00:43:53,630 --> 00:43:59,990
+المنحنة وهذه النتائج هي نتائج لفحص السكر على مدار
+
+534
+00:43:59,990 --> 00:44:06,550
+20 يوم على الـ X-axis هذا المنحنة لازم أحط الأيام
+
+535
+00:44:06,550 --> 00:44:10,870
+اليوم الأول، اليوم التاني، تلاتة، أربعة، خمسة،
+
+536
+00:44:10,870 --> 00:44:15,890
+ستة، لحد اليوم العشرينعلى الـ Y Axis في المنتصف
+
+537
+00:44:15,890 --> 00:44:20,150
+باجي وبحط الـ Meme الـ Meme هو الـ X Bar الوسط
+
+538
+00:44:20,150 --> 00:44:25,290
+الحسابي الوسط الحسابي قانونه مجموع القيم على عددها
+
+539
+00:44:25,290 --> 00:44:30,930
+أي قيم، قيم السكراللي طلعتها خلال عشرين يوم مش
+
+540
+00:44:30,930 --> 00:44:34,790
+اتفقنا في أول يوم في اليوم الأول شبكت ال control
+
+541
+00:44:34,790 --> 00:44:39,990
+وطلعت نتيجة السكر له بسجلها في اليوم التاني بشتغل
+
+542
+00:44:39,990 --> 00:44:44,350
+ال control برضه و بسجل نتيجة السكر له في اليوم
+
+543
+00:44:44,350 --> 00:44:48,790
+التالت برضه بشتغل ال control و بشتغله فحص السكر و
+
+544
+00:44:48,790 --> 00:44:55,570
+بسجل نتيجته إذا صار عندي عشرين نتيجة للسكربروح
+
+545
+00:44:55,570 --> 00:45:00,990
+أجمع العشرين قيمة على عددهم وبطلّع الـ X bar أو ما
+
+546
+00:45:00,990 --> 00:45:05,450
+يسمى الـ mean الوسط الحسابي وهدول العشرين قيمة
+
+547
+00:45:05,450 --> 00:45:09,550
+برضه بروح أحسبلهم لـ standard deviation مقدار
+
+548
+00:45:09,550 --> 00:45:16,150
+التشططبالقانون اللي انت عارفينه بعدين بروح احسب ال
+
+549
+00:45:16,150 --> 00:45:21,610
+statistical limit الحدود اللي فوق المين واللي تحت
+
+550
+00:45:21,610 --> 00:45:28,250
+المين فوق المين ايش plus واحد هذا عبارة عن كيف
+
+551
+00:45:28,250 --> 00:45:34,560
+بحسبه بروح اجيبالـ mean زائد واحد standard
+
+552
+00:45:34,560 --> 00:45:41,120
+deviation بتجيب الوسط الحسابي و بتجمعي لواحد ضرب
+
+553
+00:45:41,120 --> 00:45:46,860
+الـ standard deviation اللي حسبتيه فوق X bar زائد
+
+554
+00:45:46,860 --> 00:45:53,330
+اتنين SDالوسط الحسابي بتجمعيه للـ Standard
+
+555
+00:45:53,330 --> 00:45:59,570
+Deviation مضروب في 2 فوق X bar زائد 3SD الوسط
+
+556
+00:45:59,570 --> 00:46:05,170
+الحسابي بتجمعيه لـ 3 مضروب في الـ Standard
+
+557
+00:46:05,170 --> 00:46:14,580
+Deviation تحت الـ Main عندي –1S –2S –3Sبرضه بتجيبي
+
+558
+00:46:14,580 --> 00:46:19,400
+الوسط الحسابي و بتطرحي من واحد standard deviation
+
+559
+00:46:19,400 --> 00:46:22,220
+واحد standard deviation كلكم عارفين واحد ضرب
+
+560
+00:46:22,220 --> 00:46:26,000
+standard deviation بعدين بتجيبي X bar الوسط
+
+561
+00:46:26,000 --> 00:46:30,200
+الحسابي بتطرحي من ال standard deviation مضروب في
+
+562
+00:46:30,200 --> 00:46:35,120
+اتنين برضه الوسط الحسابي بتطرحي من ال standard
+
+563
+00:46:35,120 --> 00:46:39,780
+deviation مضروب في تلاتة و بتجيبي الحدود ما فوق ال
+
+564
+00:46:39,780 --> 00:46:45,270
+mean و ما تحت ال meanهذا الـ Chart بنسميه الـ Levy
+
+565
+00:46:45,270 --> 00:46:50,330
+-Jones Chart وبعدين بتيجي في اليوم الأول جداش طلع
+
+566
+00:46:50,330 --> 00:46:54,890
+مستوى السكر بتمثل النقطة في اليوم التاني جداش طلع
+
+567
+00:46:54,890 --> 00:46:58,830
+مستوى السكر بتمثل النقطة زي ما هو ممثل وفي اليوم
+
+568
+00:46:58,830 --> 00:47:02,970
+التالت والرابع وهاكذا وبعد هيك بتوصلي ما بين
+
+569
+00:47:02,970 --> 00:47:09,360
+النقاط هيك أنا بكونمثلت نتائج الـ Control خلال
+
+570
+00:47:09,360 --> 00:47:15,180
+عشرين يوم لفحص السكر مثلا أو فحص Enzyme على منحنة
+
+571
+00:47:15,180 --> 00:47:20,160
+الـ Levy-Jones Chart بهاي الـ Slide بس بديوا ياكوا
+
+572
+00:47:20,160 --> 00:47:24,080
+تعرفوا كيف بنحسب الـ Mean الوسط الحسابي مجموع
+
+573
+00:47:24,080 --> 00:47:28,460
+القيم على عددها وكيف بنحسب مقدار تشطط الـ Standard
+
+574
+00:47:28,460 --> 00:47:32,080
+Deviation بالقانون اللي أخدته بالإحصاء coefficient
+
+575
+00:47:32,080 --> 00:47:37,750
+of variation ما بدنا ياههلجيت أنا بعد ما مثّلت
+
+576
+00:47:37,750 --> 00:47:41,630
+نتائج الـ Control على الـ Levy Jenins الـ Chart
+
+577
+00:47:41,630 --> 00:47:48,330
+بدي أبدأ أشوف أنا عندي عشرين يوم وعشرين نتيجة على
+
+578
+00:47:48,330 --> 00:47:53,110
+المنحنى بدي أشوف وين في نتائج فيها مشاكل وين في
+
+579
+00:47:53,110 --> 00:47:58,950
+نتائج كانت ضمن الوضع الطبيعي للـ Control هلجيت في
+
+580
+00:47:58,950 --> 00:48:04,590
+شغل اسمهاالـ Westgard Equality Control Rules قواعد
+
+581
+00:48:04,590 --> 00:48:09,570
+اسمها Westgard Rule هذه القواعد بتخص نتائج الـ
+
+582
+00:48:09,570 --> 00:48:14,870
+control اللي احنا مثلناها على المنحنة فعلياً هي
+
+583
+00:48:14,870 --> 00:48:21,110
+six basic rulesهي 6 قواعد في أكتر بس فعلياً هي 6
+
+584
+00:48:21,110 --> 00:48:26,050
+قواعد اسمها Westgard هذه القواعد أنا ممكن أستخدمها
+
+585
+00:48:26,050 --> 00:48:30,690
+individually يعني أستخدم قاعدة واحدة فردية or in
+
+586
+00:48:30,690 --> 00:48:35,910
+combination أستخدم أكتر من قاعدة والهدف منها عشان
+
+587
+00:48:35,910 --> 00:48:41,550
+أقيم نتائج الـcontrol وأعمل interpretation تحليل
+
+588
+00:48:41,550 --> 00:48:47,500
+لنتائج الـcontrolمعظم الـ Quality Control Rules
+
+589
+00:48:47,500 --> 00:48:53,180
+معظم هذه القواعد تبعت الـ Control بتم التعبير عنها
+
+590
+00:48:53,180 --> 00:48:59,760
+بحاجة اسمها NL N جاية من number و L جاية من
+
+591
+00:48:59,760 --> 00:49:05,540
+statistical limit تمام؟ N number إيه؟ يعني number
+
+592
+00:49:05,540 --> 00:49:15,990
+شو؟الـ N number هو عدد القيم اللي فيهم مشكلة تمام
+
+593
+00:49:15,990 --> 00:49:23,070
+الـ N هي عدد القيم اللي فيهم مشكلة قيم مين؟ قيم
+
+594
+00:49:23,070 --> 00:49:29,670
+الـ controlبمعنى آخر عدد نتائج الـ control اللي
+
+595
+00:49:29,670 --> 00:49:36,030
+فيها المشكلة الـ L هي الـ statistical limit نوضحها
+
+596
+00:49:36,030 --> 00:49:43,910
+أكتر بمثال لو حكيتلك عندي قاعدة القاعدة اسمها 13S
+
+597
+00:49:43,910 --> 00:49:50,780
+تمام، هذه القاعدةكيف بدي أعملها الواحد هذا بيعبّر
+
+598
+00:49:50,780 --> 00:49:57,300
+عن un يعني عندي واحد يعني عندي قيمة واحدة من قيم
+
+599
+00:49:57,300 --> 00:50:03,140
+الـ control فيها مشكلة تلاتة S S معناها SD للـ
+
+600
+00:50:03,140 --> 00:50:07,640
+Standard Deviation تلاتة Standard Deviation معناه
+
+601
+00:50:07,640 --> 00:50:11,920
+هذا الـ statistical limit الحدود الإحصائية إذن
+
+602
+00:50:11,920 --> 00:50:18,850
+معظم قواعدالخاصة بي نتائج الـ Control بتم التعبير
+
+603
+00:50:18,850 --> 00:50:26,550
+عنها برقم وحد إحصائي NL الرقم بيعبر عن عدد النتائج
+
+604
+00:50:26,550 --> 00:50:30,610
+تبع الـ Control اللي فيها مشكلة أكمنتيجة من نتائج
+
+605
+00:50:30,610 --> 00:50:35,750
+الـ Control فيها مشكلة نتيجة، نتيجتين، تلت نتائج؟
+
+606
+00:50:35,750 --> 00:50:39,730
+زي هنا واحد، تلت أس نتيجة واحدة من نتائج الـ
+
+607
+00:50:39,730 --> 00:50:45,090
+Control فيها خلل تلت أسمعنى الكلام إيش تلاتة اسم
+
+608
+00:50:45,090 --> 00:50:49,250
+هذا الحدود الإحصائي تلاتة standard deviation تمام؟
+
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/xPijAyn9v6I.srt b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/xPijAyn9v6I.srt
new file mode 100644
index 0000000000000000000000000000000000000000..bbaabd60a32c98d96a397f70784d4dcb706b676d
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/xPijAyn9v6I.srt
@@ -0,0 +1,1441 @@
+1
+00:00:00,770 --> 00:00:04,370
+السلام عليكم ورحمة الله وبركاته، يعطيكم العافية
+
+2
+00:00:04,370 --> 00:00:08,590
+جميعًا إن شاء الله، اليوم محاضرتنا بعنوان kidney
+
+3
+00:00:08,590 --> 00:00:13,950
+function test، الفحوصات اللي بتشيك على وظائف الكلى
+
+4
+00:00:13,950 --> 00:00:19,290
+طبعًا هنا بنشوف صورة مقطعية للكلى
+
+5
+00:00:21,380 --> 00:00:24,980
+Kidney Function Test: The determination of non-
+
+6
+00:00:24,980 --> 00:00:28,480
+protein nitrogenous substances in the blood has
+
+7
+00:00:28,480 --> 00:00:33,400
+traditionally been used to monitor renal function
+
+8
+00:00:33,400 --> 00:00:38,960
+بيحكي لي هنا في بلازما الدم يوجد substances، يوجد
+
+9
+00:00:38,960 --> 00:00:43,800
+مواد، هذه المواد تعتبر من عائلة الـ non-protein
+
+10
+00:00:43,800 --> 00:00:47,920
+nitrogen. إيش يعني non-protein nitrogen؟ إن هذه
+
+11
+00:00:47,920 --> 00:00:53,480
+المواد تحتوي في تركيبها الداخلي على عنصر الـ
+
+12
+00:00:53,480 --> 00:00:58,080
+Nitrogen، تمام؟ وهذه المواد Non-protein يعني لا
+
+13
+00:00:58,080 --> 00:01:04,060
+تُعتبر من ضمن البروتينات، تمام؟ إذًا، خصائص هذه
+
+14
+00:01:04,060 --> 00:01:08,400
+المواد اللي موجودة في البلازما إن تركيبها الداخلي
+
+15
+00:01:08,400 --> 00:01:13,020
+يحتوي على عنصر الـ Nitrogen، وكمان هذه المواد لا
+
+16
+00:01:13,020 --> 00:01:18,760
+تُعتبر من ضمن البروتينات. قياس تركيز هذه المواد في
+
+17
+00:01:18,760 --> 00:01:25,120
+الدم مهم جدًا للتشيك على وظائف الكلى، وهل الكلى
+
+18
+00:01:25,120 --> 00:01:31,880
+تشتغل أم فيها مشاكل، تمام؟ النيتروجين يحتوي على
+
+19
+00:01:31,880 --> 00:01:35,800
+مصادر ليست بروتينات أو بوليبيبتيدات
+
+20
+00:01:38,460 --> 00:01:43,020
+اللي موجودة في بلازما الدم تحتوي على الـ Nitrogen
+
+21
+00:01:43,020 --> 00:01:48,340
+كعنصر أساسي في تركيبها الداخلي، لكن هذه المواد لا
+
+22
+00:01:48,340 --> 00:01:52,840
+تعتبر proteins أو polypeptides، لا تعتبر من ضمن
+
+23
+00:01:52,840 --> 00:01:57,600
+البروتينات. Useful clinical information is obtained
+
+24
+00:01:57,600 --> 00:02:03,600
+from individual components of NPN fraction. NPN
+
+25
+00:02:03,600 --> 00:02:10,480
+اختصار لـ Non-protein nitrogen fraction. يقصد هنا
+
+26
+00:02:10,480 --> 00:02:16,180
+أنه قياس تركيز هذه المواد الـ Non-protein nitrogen
+
+27
+00:02:16,180 --> 00:02:21,360
+المواد اللي بتحتوي على نيتروجين ولا تعتبر من
+
+28
+00:02:21,360 --> 00:02:26,960
+البروتينات. قياسها في بلازما الدم بيعطيني معلومات
+
+29
+00:02:26,960 --> 00:02:34,640
+سريرية طبية جيدة من أجل التشيك على وظائف الكلى. في
+
+30
+00:02:34,640 --> 00:02:37,780
+الـ introduction، نفس الكلام اللي حكيناه في الـ
+
+31
+00:02:37,780 --> 00:02:42,600
+slide اللي فات.  Nitrogen-containing compounds that
+
+32
+00:02:42,600 --> 00:02:46,800
+are not proteins or polypeptides. في بلازما الدم، في
+
+33
+00:02:46,800 --> 00:02:50,980
+عندنا مواد، هذه المواد تحتوي في تركيبها على الـ
+
+34
+00:02:50,980 --> 00:02:55,300
+nitrogen، وهذه المواد أيضًا لا تعتبر من ضمن
+
+35
+00:02:55,300 --> 00:03:01,670
+البروتينات.  The Total Non-Protein Nitrogen Can Be
+
+36
+00:03:01,670 --> 00:03:06,770
+Tested By Making A Protein-Free Filtrate.  هلأ كيف؟
+
+37
+00:03:06,770 --> 00:03:12,270
+بدنا ننتبه لما نيجي نقيس هذه المواد اللي موجودة في
+
+38
+00:03:12,270 --> 00:03:16,670
+البلازما، هذه المواد، انتبهوا، تحتوي في تركيبها
+
+39
+00:03:16,670 --> 00:03:21,750
+الداخلية على نيتروجين، ولكن هذه المواد لا تعتبر من
+
+40
+00:03:21,750 --> 00:03:26,710
+ضمن الـ proteins. يعني القياس اللي هيكون مختلف عن
+
+41
+00:03:26,710 --> 00:03:32,860
+قياس البروتينات اللي إحنا أخذناها، تمام؟ Useful
+
+42
+00:03:32,860 --> 00:03:36,800
+clinical information is obtained from individual
+
+43
+00:03:36,800 --> 00:03:41,460
+components of non-protein nitrogen fraction.
+
+44
+00:03:41,460 --> 00:03:44,820
+طبعًا لما بقيس هذه المواد، بأقيس تركيزها في
+
+45
+00:03:44,820 --> 00:03:51,680
+البلازما، هيعطيني قيمة سريرية طبية تشخيصية كويسة من
+
+46
+00:03:51,680 --> 00:03:59,910
+أجل التشيك على وظيفة الكلى.  Urea، أول هذه المواد
+
+47
+00:03:59,910 --> 00:04:04,890
+هنستعرضها، مادة الـ Urea. إذا بدنا نتفق قبل ما نبدأ
+
+48
+00:04:04,890 --> 00:04:10,930
+إن الـ Non-protein nitrogen substances، المواد اللي
+
+49
+00:04:10,930 --> 00:04:15,790
+فيها نيتروجين في تركيبها الداخلي، نيتروجين وهي لا
+
+50
+00:04:15,790 --> 00:04:20,910
+تعتبر من ضمن البروتينات. أول مادة هنحكي فيها هي
+
+51
+00:04:20,910 --> 00:04:26,640
+الـ Urea، ثاني مادة الكرياتينين، وثالث مادة الـ Uric
+
+52
+00:04:26,640 --> 00:04:31,900
+Acid. إذن يوريا، كرياتينين، Uric Acid، ثلاث مواد
+
+53
+00:04:31,900 --> 00:04:37,080
+يعتبروا non-protein nitrogen، فيهم نيتروجين لكن لا
+
+54
+00:04:37,080 --> 00:04:42,640
+يعتبروا بروتينات، ما بنعتبرهم بروتين، تمام؟ وهذه
+
+55
+00:04:42,640 --> 00:04:47,920
+الثلاث مواد، وهذه الثلاث فحوصات الدكتور بيطلبهم مع
+
+56
+00:04:47,920 --> 00:04:52,900
+بعض من أجل التشيك على وضع الكلى، نشوف الكلى
+
+57
+00:04:52,900 --> 00:04:59,240
+بتشتغل أو فيها مشاكل ولا لا، تمام؟ أول مادة الـ Urea
+
+58
+00:04:59,240 --> 00:05:05,220
+الـ Urea: highest concentration of non-protein
+
+59
+00:05:05,220 --> 00:05:10,100
+nitrogen in blood.  هلأ حكينا في بلازما الدم في
+
+60
+00:05:10,100 --> 00:05:15,120
+الدم يوجد يوريا، كرياتينين، ويوريك أسيد، هذه المواد
+
+61
+00:05:15,120 --> 00:05:21,710
+الثلاث مواد كلهم من عائلة الـ NPN. طيب، الـ Urea هنا في
+
+62
+00:05:21,710 --> 00:05:25,710
+المعلومة الأولى بيحكي لي إن الـ Urea موجودة بأعلى
+
+63
+00:05:25,710 --> 00:05:29,870
+تركيز. Highest concentration of non-protein
+
+64
+00:05:29,870 --> 00:05:34,730
+nitrogen in blood. يعني الـ Urea موجودة بتركيز أعلى
+
+65
+00:05:34,730 --> 00:05:39,850
+من المواد الأخرى، أعلى من الكرياتينين والـ Uric Acid
+
+66
+00:05:39,850 --> 00:05:46,660
+هي المسيطرة، تمام؟ خمسة وأربعين في المئة من الـ Non-
+
+67
+00:05:46,660 --> 00:05:51,720
+protein nitrogen عبارة عن يوريا، تمام؟! إذن، هي
+
+68
+00:05:51,720 --> 00:05:55,460
+موجودة بأعلى تركيز في الـ plasma، الدم، أعلى من
+
+69
+00:05:55,460 --> 00:05:59,840
+أخواتها الكرياتينين والـ Uric Acid. Major excretory
+
+70
+00:05:59,840 --> 00:06:04,860
+product of protein metabolism. مصدر اليوريا، يا
+
+71
+00:06:04,860 --> 00:06:10,080
+جماعة، اليوريا جاية من تكسير البروتين، يعني لما
+
+72
+00:06:10,080 --> 00:06:15,930
+ييجي الجسم يكسر البروتينات ويكسر الـ Amino Acid
+
+73
+00:06:15,930 --> 00:06:21,430
+الـ Urea بتتكون. يعني الـ Urea جاية من تكسير البروتين
+
+74
+00:06:21,430 --> 00:06:28,400
+هي excretory product من البروتين metabolism. Urea
+
+75
+00:06:28,400 --> 00:06:32,620
+is synthesized in the liver. اليوريا بتتصنع في
+
+76
+00:06:32,620 --> 00:06:38,040
+الكبد، وهلأ رح نشوف كيف بتتصنع، from CO2 and ammonia
+
+77
+00:06:38,040 --> 00:06:43,140
+بتصنع من ثاني أكسيد الكربون والأمونيا، as the final
+
+78
+00:06:43,140 --> 00:06:48,220
+product of amino acid catabolism. انتبهوا إيش بيصير
+
+79
+00:06:48,220 --> 00:06:53,580
+بالضبط. هلأ الإنسان مثلاً أكل أكل وشرب من اللحوم
+
+80
+00:06:53,580 --> 00:06:58,550
+مليانة بروتينات؟ هلأ جات البروتين؟ كل بروتين له half-
+
+81
+00:06:58,550 --> 00:07:01,930
+life، له عمر معين في الجسم، بعد هيك بيصير
+
+82
+00:07:01,930 --> 00:07:06,810
+catabolism، بيصير له تكسير، degradation. هلأ جات؟
+
+83
+00:07:06,810 --> 00:07:11,270
+لما البروتينات تتكسر، يعني الـ amino acid رح تتكسر
+
+84
+00:07:11,630 --> 00:07:16,690
+لما بيصير عندي تكسير في الأحماض الأمينية، نتيجة
+
+85
+00:07:16,690 --> 00:07:21,830
+التكسير بيصير عندنا release، خروج، لمركب اسمه الـ
+
+86
+00:07:21,830 --> 00:07:28,310
+ammonia، الـ NH3. إذًا الأمونيا هو مركب جاي من تكسير
+
+87
+00:07:28,310 --> 00:07:32,650
+الـ Amino Acid، من تكسير الأحماض الأمينية. هلأ
+
+88
+00:07:32,650 --> 00:07:37,330
+الأمونيا لو ضلت في الدم يا جماعة هي waste product
+
+89
+00:07:37,330 --> 00:07:42,180
+هي فضلات، لازم الجسم يتخلص منها.  فلو ضلت الأمونيا في
+
+90
+00:07:42,180 --> 00:07:46,860
+الدم تعمل تسمم وممكن تؤدي إلى الوفاة. فالجسم بده
+
+91
+00:07:46,860 --> 00:07:51,900
+يتخلص من الأمونيا بشكل سريع. الأمونيا اللي اتكونت
+
+92
+00:07:51,900 --> 00:07:57,860
+بتروح على الـ liver، على الكبد، وهناك في الكبد إيش
+
+93
+00:07:57,860 --> 00:08:04,300
+بيعمل الكبد؟ بيروح هو بيربط هذه الأمونيا بـ 2 CO2
+
+94
+00:08:04,300 --> 00:08:09,900
+بجزيئين من الـ CO2، من ثاني أكسيد الكربون، يعني
+
+95
+00:08:09,900 --> 00:08:15,020
+الأمونيا واتنين CO2 بيربطوا مع بعض، وهذا المركب
+
+96
+00:08:15,020 --> 00:08:20,120
+الناتج عن ربط الأمونيا مع الـ CO2 بيعطيني مركب اسمه
+
+97
+00:08:20,120 --> 00:08:26,200
+يوريا. إذًا اليوريا عبارة عن أمونيا مربوط معها اتنين
+
+98
+00:08:26,200 --> 00:08:33,280
+CO2، تمام؟ فبتتكون اليوريا في الكبد، وبعد هيك
+
+99
+00:08:33,280 --> 00:08:38,520
+اليوريا اللي اتكونت في الكبد بتنقلها مع الدم إلى
+
+100
+00:08:38,520 --> 00:08:45,440
+الكلى عشان الكلى إيش تعمل؟ تعمل excretion لليوريا
+
+101
+00:08:45,440 --> 00:08:49,820
+عن طريق اليورين، يعني بتطلع اليوريا مع اليورين
+
+102
+00:08:49,820 --> 00:08:54,840
+مع الـ bowel لخارج الجسم، لأن اتفقنا اليوريا waste
+
+103
+00:08:54,840 --> 00:09:00,590
+product، فضلات، تمام؟ It is freely filtered at the
+
+104
+00:09:00,590 --> 00:09:03,470
+glomerulus. هلأ اليوريا اللي اتكونت في الكبد
+
+105
+00:09:03,470 --> 00:09:08,030
+بتنقل مع الدم وبتروح على الكلى عشان يصير فيه فلترة
+
+106
+00:09:08,030 --> 00:09:12,750
+وهذه اليوريا الجسم بيعرف أنها waste product، فضلات، و
+
+107
+00:09:12,750 --> 00:09:18,930
+لازم تطلع مع الـ urine، مع البول. So 40% specifically
+
+108
+00:09:20,010 --> 00:09:24,950
+is passively reabsorbed by the proximal tubules. 40%
+
+109
+00:09:24,950 --> 00:09:30,850
+من اليوريا الكلى بتعمل لها reabsorption، بترجعها للدم
+
+110
+00:09:30,850 --> 00:09:39,290
+و 60% من اليوريا بيخرج كفضلات مع الـ urine، مع الـ
+
+111
+00:09:39,290 --> 00:09:44,590
+urine، تمام؟ إذًا كمان مرة يا جماعة اليوريا موجودة
+
+112
+00:09:44,590 --> 00:09:48,810
+بأعلى تركيز في البلازما، أعلى شيء في الـ
+
+113
+00:09:48,810 --> 00:09:53,550
+Non-protein nitrogen. اليوريا، واليوريا جاية من
+
+114
+00:09:53,550 --> 00:09:59,640
+تكسير البروتينات. كيف بتتصنع اليوريا بالضبط؟  الحقيقة
+
+115
+00:09:59,640 --> 00:10:03,800
+أنه البروتين لما بيصير له تكسير، يعني الأحماض
+
+116
+00:10:03,800 --> 00:10:08,120
+الأمينية رح تتكسر. لما الأحماض الأمينية تتكسر بيصير
+
+117
+00:10:08,120 --> 00:10:13,200
+عندي release، لمركب الأمونيا، الـ NH3. الأمونيا لو ضلت
+
+118
+00:10:13,200 --> 00:10:17,100
+في الدم رح يعمل مشاكل للإنسان وممكن يؤدي إلى الوفاة.
+
+119
+00:10:17,340 --> 00:10:22,000
+فالأمونيا فضلات لازم تطلع من الجسم، فبتنقل
+
+120
+00:10:22,000 --> 00:10:27,140
+الأمونيا على الكبد. في الكبد، الكبد بيعمل على ربط
+
+121
+00:10:27,140 --> 00:10:34,680
+الأمونيا بـ 2CO2. الأمونيا مع 2CO2 بيعطيني مركب اسمه
+
+122
+00:10:34,680 --> 00:10:39,780
+اليوريا. إذًا اليوريا فضلات جاية من الأمونيا، أصلها
+
+123
+00:10:39,780 --> 00:10:44,470
+أمونيا، تمام؟ هلأ الـ Urea اللي في الكبد بتنقل
+
+124
+00:10:44,470 --> 00:10:51,310
+على الـ kidney، الكلى، عشان الكلى فقط تأخذ 40% من
+
+125
+00:10:51,310 --> 00:10:56,430
+الـ Urea بترجعها للدم، والكمية الأكبر من الـ Urea
+
+126
+00:10:56,430 --> 00:11:03,680
+بتنخرجها مع الـ Urine، مع الفضلات، تمام؟ إذًا اليوريا
+
+127
+00:11:03,680 --> 00:11:08,980
+هي فضلات، okay. هي موجودة في دم الكلى، رجعت نسبة
+
+128
+00:11:08,980 --> 00:11:13,900
+للدّم. يعني اليوريا موجودة بتركيز معين في الدم، لكن
+
+129
+00:11:13,900 --> 00:11:18,520
+أغلبها بيصير له excretion، بيخرج مع اليورين.
+
+130
+00:11:20,920 --> 00:11:26,180
+Blood urea levels can vary proportionally with. هلأ
+
+131
+00:11:26,180 --> 00:11:31,540
+يا جماعة، بيحكي لي تركيز اليوريا في الدم مختلف، وفي
+
+132
+00:11:31,540 --> 00:11:38,100
+حالة اختلاف، والتركيز بيختلف بناء على عدة عوامل. أول
+
+133
+00:11:38,100 --> 00:11:41,800
+عامل، The protein content of the diet، الأكل اللي
+
+134
+00:11:41,800 --> 00:11:46,720
+أنت بتاكله، قد إيش فيه بروتينات. لو أنت أكلت أكل مليان
+
+135
+00:11:46,720 --> 00:11:51,260
+بروتينات، يعني في الجسم رح يصير تكسير لهذه البروتينات،
+
+136
+00:11:51,260 --> 00:11:55,840
+يعني تكسير للأحماض الأمينية، معناه الأمونيا رح تطلع
+
+137
+00:11:55,840 --> 00:12:02,420
+كتيرة، معناه اليوريا رح تتكون بكميات أكبر. يعني الأكل
+
+138
+00:12:02,420 --> 00:12:08,430
+اللي أنت بتاكله بحدد تركيز اليوريا، تمام؟ الـ Rate
+
+139
+00:12:08,430 --> 00:12:12,950
+of protein catabolism during tissue breakdown.
+
+140
+00:12:12,950 --> 00:12:18,810
+معدل تكسير للبروتين. حكينا، قد ما أنت بتاكل diet، أكل
+
+141
+00:12:18,810 --> 00:12:24,790
+فيه بروتينات، معناه معدل التكسير رح يكون أكثر، تمام؟
+
+142
+00:12:24,790 --> 00:12:30,350
+وبالتالي release للأمونيا، والأمونيا رح تتحول ليوريا
+
+143
+00:12:30,350 --> 00:12:36,090
+بكميات أكبر. And liver function، يعني الناس اللي
+
+144
+00:12:36,090 --> 00:12:39,550
+عندها مشكلة في الكبد يا جماعة، أكلوا أكلات فيها
+
+145
+00:12:39,550 --> 00:12:44,170
+بروتينات، اتكسر البروتين، طلع أمونيا. هلأ الأمونيا
+
+146
+00:12:44,170 --> 00:12:48,310
+رح تروح تلاقي الكبد. في الكبد بده يربط الأمونيا بالـ
+
+147
+00:12:48,310 --> 00:12:53,130
+CO2. طب لو الكبد فيه مشكلة، معناه مش رح يقدر يربط
+
+148
+00:12:53,130 --> 00:12:58,210
+الأمونيا بالـ CO2، معناه اليوريا مش رح تتكون صح ولا
+
+149
+00:12:58,210 --> 00:13:05,820
+لأ؟ إذًا هذه الثلاث عوامل بتحدد تركيز اليوريا في الدم،
+
+150
+00:13:05,820 --> 00:13:11,640
+تمام؟ Because it is a metabolic product. Urea is a non-
+
+151
+00:13:11,640 --> 00:13:15,720
+specific indicator of renal function. يا جماعة،
+
+152
+00:13:15,720 --> 00:13:21,320
+اليوريا فحص من الفحوصات اللي بتشيك على وظائف الكلى
+
+153
+00:13:21,320 --> 00:13:28,240
+sorry، على وظائف الكلى. كيف؟ هلأ أنا لو إنسان سليم
+
+154
+00:13:28,240 --> 00:13:33,300
+حكينا اليوريا اللي اتكونت بتجي على الكلى مع الدم،
+
+155
+00:13:33,300 --> 00:13:36,800
+بتكون محمولة في بلازما الدم على الـ kidney، على
+
+156
+00:13:36,800 --> 00:13:41,780
+الكلى. الكلى بتطلع 60% من اليوريا مع الـ urine برا
+
+157
+00:13:41,780 --> 00:13:47,900
+الجسم، 40% بيصير له إعادة امتصاص لبلازما الدم. أما
+
+158
+00:13:47,900 --> 00:13:52,280
+الإنسان اللي عنده Renal Failure، عنده فشل كلوي أو
+
+159
+00:13:52,280 --> 00:13:57,740
+عنده مشكلة معينة في الكلى، هلأ بيجي الدم محمل
+
+160
+00:13:57,740 --> 00:14:01,480
+باليوريا على الـ kidney، عشان الـ kidney بدها تطلع
+
+161
+00:14:01,480 --> 00:14:05,780
+اليوريا مع الـ urine، بس لأن الـ kidney فيها مشكلة،
+
+162
+00:14:05,780 --> 00:14:11,980
+فيها مشاكل، ما بتقدر تعمل فلترة، ما بتقدر تطلع
+
+163
+00:14:11,980 --> 00:14:17,530
+اليوريا مع الـ urine، وبالتالي إيش رح يصير؟ رح يصير تراكم
+
+164
+00:14:17,530 --> 00:14:22,130
+لليوريا في بلازما الدم، رح تظل اليوريا محجوزة في
+
+165
+00:14:22,130 --> 00:14:26,350
+الدم، مش رح تطلع في الـ Urine. إذًا للناس اللي عندها
+
+166
+00:14:26,350 --> 00:14:32,180
+مشاكل في الكلى، لو جينا فحصنا لهم اليوريا، رح نلاقي
+
+167
+00:14:32,180 --> 00:14:36,740
+تركيزها عالي جدًا، ليش؟ لأن الكلى واقفة، عندهم ما
+
+168
+00:14:36,740 --> 00:14:41,600
+بتشتغل، وبالتالي مش رح تقدر تفلتر اليوريا، مش رح تقدر
+
+169
+00:14:41,600 --> 00:14:45,100
+تطلع اليوريا، هذه اليوريا فضلات، يفترض تطلع مع
+
+170
+00:14:45,100 --> 00:14:49,740
+الـ Urine، مين بتطلعها؟ الكلى. طب لو الكلى فيها مشكلة
+
+171
+00:14:49,740 --> 00
+
+223
+00:19:01,630 --> 00:19:06,510
+اليوريا مهم جدا للتشريك على وظيفة الكلى
+
+224
+00:19:08,870 --> 00:19:13,090
+clinical significance لماذا يُطلب هذا الفحص؟
+
+225
+00:19:13,090 --> 00:19:18,170
+associated with elevated levels of urea in blood
+
+226
+00:19:18,170 --> 00:19:23,410
+are referred to as uremia or azotemia. ارتفاع مستوى
+
+227
+00:19:23,410 --> 00:19:29,570
+اليوريا في الدم هذه حالة مرضية نسميها uremia أو
+
+228
+00:19:29,570 --> 00:19:33,630
+أزوتيميا. uremia أو أزوتيميا تعني اليوريا مرتفعة
+
+229
+00:19:33,630 --> 00:19:39,710
+في بلازما الدم. Causes of Urea Plasma Elevation
+
+230
+00:19:39,710 --> 00:19:44,410
+أسباب ارتفاع اليوريا في الدم. حكينا أسباب كثيرة،
+
+231
+00:19:44,410 --> 00:19:48,350
+حكينا الجفاف، حكينا النزلات المعوية، حكينا الناس
+
+232
+00:19:48,350 --> 00:19:51,790
+الذين يتناولون أكلات مليئة بالبروتينات، الناس الذين لديهم
+
+233
+00:19:51,790 --> 00:19:57,150
+مشاكل في الكلى، هذه كلها أسباب تسبب أو تعمل
+
+234
+00:19:57,150 --> 00:20:02,530
+على ارتفاع في اليوريا في الدم. إذن الأسباب تنقسم إلى
+
+235
+00:20:02,530 --> 00:20:07,170
+ثلاثة أسباب: Pre-renal (ما قبل الكلى)، Renal (الكلى)،
+
+236
+00:20:07,170 --> 00:20:10,850
+Post-renal (ما بعد الكلى).  لنرى حالات الـ Pre-
+
+237
+00:20:10,850 --> 00:20:15,160
+renal. يا جماعة، الـ Prerenal يعني المشكلة ليست في
+
+238
+00:20:15,160 --> 00:20:19,440
+الكلى، المشكلة أنه لديه Gastroenteritis، لديه نزلة
+
+239
+00:20:19,440 --> 00:20:24,620
+معوية، يعني يفقد سوائل، لديه dehydration (جفاف)،
+
+240
+00:20:24,620 --> 00:20:30,020
+إسهال، vomiting (قيء). فقد السوائل يؤدي إلى تركيز
+
+241
+00:20:30,020 --> 00:20:34,520
+المركبات الموجودة في بلازما الدم، ومثال عليها
+
+242
+00:20:34,520 --> 00:20:39,690
+اليوريا، يعني اليوريا سيرتفع تركيزها، أو إذا تناولت
+
+243
+00:20:39,690 --> 00:20:44,190
+أكلات مليئة بالبروتينات، أيضا تركيز اليوريا لديك في
+
+244
+00:20:44,190 --> 00:20:50,170
+الدم سيرتفع. هذه حالات الـ Pre-renal، تمام؟ أما
+
+245
+00:20:50,170 --> 00:20:54,830
+حالات الـ Renal، يعني مشكلة في الكلى نفسها، غير قادرة
+
+246
+00:20:54,830 --> 00:20:59,050
+على الترشيح، وغير قادرة على إخراج اليوريا مع الـ urine خارج
+
+247
+00:20:59,050 --> 00:21:04,430
+الجسم، وبالتالي تركيز اليوريا سيرتفع. أما الـ Post-
+
+248
+00:21:04,430 --> 00:21:09,650
+Renal، يعني مشاكل ما بعد الكلى، يعني مشاكل في
+
+249
+00:21:09,650 --> 00:21:14,690
+المسالك البولية، الـ urinary tract.  هل الكلى
+
+250
+00:21:14,690 --> 00:21:20,090
+تعمل بشكل جيد؟ وترشح اليوريا، وأخرجت اليوريا مع الـ
+
+251
+00:21:20,090 --> 00:21:24,130
+urine.  تتحرك في المسالك البولية، في الـ Urinary
+
+252
+00:21:24,130 --> 00:21:28,330
+tract. تخيلوا أنه يوجد Stones (حصوات)، حصى في
+
+253
+00:21:28,330 --> 00:21:33,730
+المسالك البولية، الحصى هذه ستمنع اليوريا من
+
+254
+00:21:33,730 --> 00:21:38,950
+الخروج مع الـ urine، وبالتالي ستبقى اليوريا محصورة في
+
+255
+00:21:38,950 --> 00:21:43,590
+الجسم، ولن تستطيع الخروج مع الـ urine، وبالتالي تركيزها
+
+256
+00:21:43,590 --> 00:21:48,160
+في الدم سيكون عاليا. إذن الـ Postrenal، إن الكلى
+
+257
+00:21:48,160 --> 00:21:53,960
+تعمل بشكل جيد، ولكن المشكلة في المسالك البولية، فيها
+
+258
+00:21:53,960 --> 00:22:02,380
+حصوات منعت خروج الـUrea مع الـUrine. Parallel
+
+259
+00:22:02,380 --> 00:22:06,600
+determination of urea and creatinine is performed
+
+260
+00:22:06,600 --> 00:22:10,520
+to differentiate between pre-renal and post-renal
+
+261
+00:22:10,520 --> 00:22:14,540
+azothemia. يا جماعة، هذه الثلاث مكونات التي
+
+262
+00:22:14,540 --> 00:22:18,120
+نتحقق منها لوظائف الكلى: الـ urea، و الـ creatinine، و
+
+263
+00:22:18,120 --> 00:22:22,280
+الـ uric acid.  يفترض، من أجل التحقق من وظائف الكلى، أن
+
+264
+00:22:22,560 --> 00:22:27,460
+أجرى الفحوصات الثلاثة بشكل موازٍ، الثلاثة معا، يعني
+
+265
+00:22:27,460 --> 00:22:31,520
+الطبيب يجب أن يطلب الثلاثة معا للتحقق من
+
+266
+00:22:31,520 --> 00:22:36,650
+وظيفة الكلى بشكل صحيح.  لما يطلب الطبيب
+
+267
+00:22:36,650 --> 00:22:42,090
+فحص اليوريا وفحص الكرياتينين معا، هذا يساعد في
+
+268
+00:22:42,090 --> 00:22:47,590
+التمييز بين الحالة الأولى، الـ Pre-renal، والحالة
+
+269
+00:22:47,590 --> 00:22:52,110
+الثالثة، الـ Post-renal.  في الـ Pre-renal،
+
+270
+00:22:52,110 --> 00:22:58,290
+اليوريا تزداد، لكن الكرياتينين، المادة الأخرى، يكون
+
+271
+00:22:58,290 --> 00:23:04,570
+طبيعيا، لأن الكرياتينين، عندما نأخذه، لا يتأثر
+
+272
+00:23:04,570 --> 00:23:09,630
+بالطعام، بالـ diet، ولا يتأثر بالجفاف، يعني لو حدث
+
+273
+00:23:09,630 --> 00:23:14,270
+جفاف، فلن يزداد تركيزه، تمام؟ إذن في حالات الـ
+
+274
+00:23:14,270 --> 00:23:19,880
+pre-renal فقط اليوريا تزداد، أما الكرياتينين لا. أما
+
+275
+00:23:19,880 --> 00:23:26,340
+حالات الـ Post-Renal، اليوريا والكرياتينين يرتفعان
+
+276
+00:23:26,340 --> 00:23:31,360
+تركيزهما في الدم، وكلاهما يتأثران، لأن الكرياتينين
+
+277
+00:23:31,360 --> 00:23:35,260
+أيضا يريد الخروج مع اليوريا، ويريد الخروج مع الـ urine
+
+278
+00:23:35,260 --> 00:23:39,320
+خارج الجسم، فلو وجدت حصوات في المسالك البولية،
+
+279
+00:23:39,320 --> 00:23:43,740
+اليوريا والكرياتينين، المادتان معا، سيبقيان
+
+280
+00:23:43,740 --> 00:23:49,270
+محبوسان في الدم وفي الجسم، تمام؟ فعمل فحص اليوريا
+
+281
+00:23:49,270 --> 00:23:55,350
+والكرياتينين معا، من خلالهما أستطيع التمييز، هل الحالة
+
+282
+00:23:55,350 --> 00:24:01,230
+pre-renal أم post-renal، تمام؟ في الـ pre-renal،
+
+283
+00:24:01,230 --> 00:24:05,850
+فقط ما يزيد هو اليوريا، الكرياتينين طبيعي، أما
+
+284
+00:24:05,850 --> 00:24:10,470
+الـ post-renal، اليوريا والكرياتينين يكونان عالين،
+
+285
+00:24:10,470 --> 00:24:17,040
+وكلاهما يكون غير طبيعي.  إجاني شخص يريد إجراء فحص
+
+286
+00:24:17,040 --> 00:24:21,900
+الـ Urea Test.  ما نوع العينة؟ Serum أو بلازما، و
+
+287
+00:24:21,900 --> 00:24:26,660
+البلازما، نوع الـ Anticoagulant، الهيبارين، يمكن استخدامه
+
+288
+00:24:26,660 --> 00:24:32,400
+في طريقة urease glutamate dehydrogenase. هذه
+
+289
+00:24:32,400 --> 00:24:39,200
+اسم الطريقة لإجراء فحص اليوريا. أما الـ Anticoagulant
+
+290
+00:24:39,200 --> 00:24:45,050
+الفلوريد، لو استخدمته، طبعا هو ممنوع استخدامه
+
+291
+00:24:45,050 --> 00:24:50,210
+كمادة  Anticoagulant، لأنه لو استخدمته، سيؤثر
+
+292
+00:24:50,210 --> 00:24:56,110
+على تفاعل اليوريا، سيؤثر على التفاعل الذي سيحدث بين
+
+293
+00:24:56,110 --> 00:25:01,270
+الـ Reagent الخاص باليوريا، وما بين اليوريا الموجودة
+
+294
+00:25:01,270 --> 00:25:05,650
+في الـ Plasma للمريض. Therefore, methods
+
+295
+00:25:05,650 --> 00:25:11,010
+employing Urea's cannot use serum preserved with
+
+296
+00:25:11,010 --> 00:25:15,110
+fluoride.  لذلك، ممنوع استخدام الـ Anticoagulant
+
+297
+00:25:15,110 --> 00:25:20,510
+Fluoride، لأنه سيؤثر على التفاعل الذي سيحدث بين
+
+298
+00:25:20,510 --> 00:25:25,750
+عينات المريض والـ Reagent الخاص باليوريا.  أيضا، الـ
+
+299
+00:25:25,750 --> 00:25:30,470
+Ammonium Heparin، هذه المادة Anticoagulant  أيضا ممنوع
+
+300
+00:25:30,470 --> 00:25:37,310
+استخدامه، تمام؟ في طريقة الـ Urease Methods، هذه إحدى
+
+301
+00:25:37,310 --> 00:25:42,160
+الطرق التي نعمل بها فحص اليوريا. لأنه يا جماعة،
+
+302
+00:25:42,160 --> 00:25:48,460
+اليوريا، حكينا، هي عبارة عن أمونيا و CO2. لو كسرنا
+
+303
+00:25:48,460 --> 00:25:54,340
+اليوريا  بإنزيم اليوريز، سيظهر أمونيا و CO2. فأنتم
+
+304
+00:25:54,340 --> 00:25:59,210
+لو استخدمتم الـ Ammonium-Heparin، الـ Ammonium، هذا الـ
+
+305
+00:25:59,210 --> 00:26:03,390
+Anticoagulant، لو تكسّر، سيعطيني أمونيا أيضا،
+
+306
+00:26:03,390 --> 00:26:07,370
+وبالتالي سيرتفع تركيز الأمونيا في العينة،
+
+307
+00:26:07,370 --> 00:26:12,730
+ولا أريد أي مؤثرات خارجية تؤثر على تفاعل
+
+308
+00:26:12,730 --> 00:26:17,610
+الفحص. إذن الـ Ammonium-Heparin ممنوع كـ
+
+309
+00:26:17,610 --> 00:26:22,380
+Anticoagulant، ممنوع استخدامه لأنه يحتوي على أمونيا، والـ
+
+310
+00:26:22,380 --> 00:26:26,100
+تفاعل نفسه الذي سيحدث سيحتوي على أمونيا،
+
+311
+00:26:26,100 --> 00:26:31,000
+وأمونيا، ويوريا، تمام. ثم، الـ DA، مؤثرات خارجية،
+
+312
+00:26:31,000 --> 00:26:35,760
+تؤثر على الفحص. قابلية السيرم،
+
+313
+00:26:35,760 --> 00:26:39,840
+و البلازما، تبقى سبعة أيام في الثلاجة، وتبقى سنة
+
+314
+00:26:39,840 --> 00:26:43,520
+محفوظة في الفريزر. because of urea
+
+315
+00:26:43,520 --> 00:26:48,140
+susceptibility to bacterial degradation. سيرم و
+
+316
+00:26:48,140 --> 00:26:52,720
+عينات البول يجب أن تبقى عند أربعة إلى ثمانية درجات
+
+317
+00:26:52,720 --> 00:26:57,400
+مئوية حتى التحليل. يا جماعة، العينة سيرم أو
+
+318
+00:26:57,400 --> 00:27:02,380
+بلازما أو بول، نحن قلنا 60% من اليوريا تخرج
+
+319
+00:27:02,380 --> 00:27:06,060
+مع البول، يعني أنا ممكن أجرى تحليل لتركيز اليوريا في
+
+320
+00:27:06,060 --> 00:27:10,240
+البول، يعني العينة ممكن أن تكون بول، سواء بول
+
+321
+00:27:10,240 --> 00:27:16,180
+أو سيرم. يفضل حفظ العينة في الثلاجة، ألا نتركها عند
+
+322
+00:27:16,180 --> 00:27:20,530
+درجة حرارة الغرفة، لأن لو عينة البول أو عينة
+
+323
+00:27:20,530 --> 00:27:25,650
+السيرم بقيت خارجا، ممكن تتلوث ببكتيريا، bacterial
+
+324
+00:27:25,650 --> 00:27:29,070
+contamination.  طيب، ما تتلوث ببكتيريا، ماذا ستفعل
+
+325
+00:27:29,070 --> 00:27:33,240
+البكتيريا؟ كل ما أخذناه في الكائنات الحية الدقيقة، وفي
+
+326
+00:27:33,240 --> 00:27:36,880
+علم الأحياء الدقيقة، أنه يوجد بكتيريا تفرز إنزيم
+
+327
+00:27:36,880 --> 00:27:41,340
+اليوريز. تخيلوا، أن عينة البول، يعني هي عينة
+
+328
+00:27:41,340 --> 00:27:45,860
+البول فيها يوريا، وتلوثت ببكتيريا تفرز
+
+329
+00:27:45,860 --> 00:27:50,600
+اليوريز، اليوريز سيكسر اليوريا الموجودة في عينة
+
+330
+00:27:50,600 --> 00:27:56,650
+البول، وبالتالي تصبح العينة غير صالحة للفحص، صحيح
+
+331
+00:27:56,650 --> 00:28:00,510
+أم لا؟ إذن أنا أخشى أن تتلوث عينة السيرم أو عينة
+
+332
+00:28:00,510 --> 00:28:04,790
+البول، البكتيريا تفرز اليوريز، هذا اليوريز
+
+333
+00:28:04,790 --> 00:28:09,050
+لو أُفرز، سيكسر اليوريا التي أريد تحليلها،
+
+334
+00:28:09,050 --> 00:28:12,970
+وبالتالي سيكون لدي مشاكل، لهذا السبب نفضل حفظ
+
+335
+00:28:12,970 --> 00:28:18,860
+العينة في الثلاجة.  نكمل في العينة، one can
+
+336
+00:28:18,860 --> 00:28:24,200
+analyze urine after واحد إلى عشرين إلى واحد إلى خمسين أو
+
+337
+00:28:24,200 --> 00:28:30,940
+واحد إلى مئة. sample dilution dependent on
+
+338
+00:28:30,940 --> 00:28:35,230
+the method and instrument employed.  يقول لي إنه لما
+
+339
+00:28:35,230 --> 00:28:39,070
+تريد أخذ عينة بول وفحص تركيز اليوريا فيها،
+
+340
+00:28:39,070 --> 00:28:44,250
+قبل أن تبدأ في الفحص، يجب تخفيف عينة البول،
+
+341
+00:28:44,250 --> 00:28:50,090
+لماذا؟ لأن 60% من اليوريا موجودة في البول، يعني
+
+342
+00:28:50,090 --> 00:28:54,690
+تركيز اليوريا في البول عالي جدا، لهذا السبب قبل
+
+343
+00:28:54,690 --> 00:29:00,130
+أن أبدأ الفحص، معظم الكواشف تقول: خفف
+
+344
+00:29:00,130 --> 00:29:06,430
+العينة.  أخفف تركيز اليوريا قبل أن تبدأ الفحص،
+
+345
+00:29:06,430 --> 00:29:13,390
+إما التخفيف 21 أو 51 أو 100، حسب الكاشف، ماذا يقول؟
+
+346
+00:29:13,390 --> 00:29:18,070
+لماذا أخفف عينة البول؟ لأن تركيز اليوريا في
+
+347
+00:29:18,070 --> 00:29:23,010
+البول عالي جدا، مركّزة جدا، فيجب تخفيفها قبل
+
+348
+00:29:23,010 --> 00:29:28,840
+أن أبدأ الفحص. One can also preserve urine sample
+
+349
+00:29:28,840 --> 00:29:33,440
+by maintaining the pH at least down 4. يعني أيضا،
+
+350
+00:29:33,440 --> 00:29:36,660
+عينة البول، لحمايتها من تلوث البكتيريا،
+
+351
+00:29:36,660 --> 00:29:41,280
+contamination. غير أني أضعها في الثلاجة دائما، يجب
+
+352
+00:29:41,280 --> 00:29:46,340
+أن أحاول جعلها حمضية، يعني البول يكون الـ pH
+
+353
+00:29:46,340 --> 00:29:52,520
+تبعه حمضي، أقل من 4، لمنع نمو البكتيريا في
+
+354
+00:29:52,520 --> 00:29:57,210
+البول.  وعينة البول ممكن أن تحفظ في الثلاجة سبعة
+
+355
+00:29:57,210 --> 00:30:01,730
+أيام، أو لمدة شهر في الفريزر. وأي contaminated
+
+356
+00:30:01,730 --> 00:30:05,850
+specimen، أي عينة ملوثة بالبكتيريا، يجب أن أُجري لها
+
+357
+00:30:05,850 --> 00:30:11,890
+discard، أرميها وأتخلص منها، وتكون غير صالحة للفحص.
+
+358
+00:30:13,370 --> 00:30:18,410
+الـ Analytical Methods، وهي طرق تحليل اليوريا
+
+359
+00:30:18,410 --> 00:30:23,670
+مختلفة، تمام؟ وسنراها معا. Assays for urea were
+
+360
+00:30:23,670 --> 00:30:27,490
+based on measuring the amount of nitrogen in the
+
+361
+00:30:27,490 --> 00:30:32,510
+sample.  يوريا نيتروجين.  يوجد Assays، يوجد
+
+362
+00:30:32,510 --> 00:30:37,870
+طرق، هذه الطرق تقيس اليوريا في البلازما بطرق غير
+
+363
+00:30:37,870 --> 00:30:41,830
+مباشرة، يعني لا تقيس اليوريا directly، ماذا
+
+364
+00:30:41,830 --> 00:30:46,750
+تقيس؟ تقيس تركيز النيتروجين الموجود في
+
+365
+00:30:46,750 --> 00:30:51,830
+اليوريا، تمام؟  أليس صحيحا أن اليوريا مركبات تحتوي في
+
+366
+00:30:51,830 --> 00:30:56,390
+تركيبها الداخلي على عنصر النيتروجين؟  هذه الطرق
+
+367
+00:30:56,390 --> 00:31:01,890
+تقيس النيتروجين الموجود في اليوريا، لهذا السبب
+
+368
+00:31:01,890 --> 00:31:07,210
+يسمونها الـ Blood Urea Nitrogen، يعني نحن نقيس
+
+369
+00:31:07,210 --> 00:31:11,240
+النيتروجين الموجود في اليوريا. current
+
+370
+00:31:11,240 --> 00:31:16,660
+analytical methods have retained this custom and
+
+371
+00:31:16,660 --> 00:31:21,060
+اليوريا غالبا ما تُقدّم من حيث النيتروجين
+
+372
+00:31:21,060 --> 00:31:25,640
+concentration بدلا من تركيز اليوريا. وهذا
+
+373
+00:31:25,640 --> 00:31:30,760
+يُسمى يوريا نيتروجين.  يخبرني حتى الآن current
+
+374
+00:31:30,760 --> 00:31:36,830
+analytical methods، حتى الآن يوجد في الأسواق كواشف
+
+375
+00:31:36,830 --> 00:31:41,970
+تقيس تركيز النيتروجين الموجود في اليوريا، ولا
+
+376
+00:31:41,970 --> 00:31:48,330
+تقيس تركيز اليوريا مباشرة، فيسمونها blood urea
+
+377
+00:31:48,330 --> 00:31:52,690
+nitrogen، قياس النيتروجين الموجود في اليوريا.
+
+378
+00:31:53,570 --> 00:31:59,170
+طيب، لو كنت في مختبر خاص، ويعطيك تركيز النيتروجين
+
+379
+00:31:59,170 --> 00:32:04,230
+بدلا من تركيز اليوريا، يوجد هناك حساب
+
+380
+00:32:04,230 --> 00:32:09,650
+وتحويل. لو حصلت على تركيز النيتروجين الموجود
+
+381
+00:32:09,650 --> 00:32:14,650
+في اليوريا، تستطيع الحصول على تركيز اليوريا نفسها، كيف؟
+
+382
+00:32:14,650 --> 00:32:20,170
+سنرى في النقطة الثالثة. Urea Nitrogen Concentration
+
+383
+00:32:20,170 --> 00:32:29,350
+تركيز النيتروجين الموجود في اليوريا، ممكن أن أحوله
+
+384
+00:32:29,350 --> 00:32:38,190
+إلى تركيز اليوريا، عن طريق ضربه في 2.14. لو حصلت
+
+385
+00:32:38,190 --> 00:32:42,650
+على تركيز النيتروجين الموجود في اليوريا، هذا
+
+386
+00:32:42,650 --> 00:32:47,930
+التركيز الخاص بالنيتروجين الذي تضربينه في 2.14
+
+387
+00:32:47,930 --> 00:32:53,530
+سيعطيك تركيز اليوريا نفسه، إذن يوجد تحويل،
+
+388
+00:32:53,530 --> 00:32:55,130
+تحويل، تمام؟
+
+389
+00:32:57,770 --> 00:33:03,030
+Urease Glutamate Dehydrogenase Method. هذا اسم
+
+390
+00:33:03,030 --> 00:33:08,870
+الطريقة التي من خلالها سنقيس تركيز اليوريا في
+
+391
+00:33:08,870 --> 00:33:14,810
+الدم. هذا المربع هو مبدأ التفاعل الذي يحدث بين
+
+392
+00:33:
+
+445
+00:37:40,080 --> 00:37:44,860
+بتحطيها خمس دقائق في الـ water bath بعد ما أخلص هذه
+
+446
+00:37:44,860 --> 00:37:50,500
+الخطوة بروح أجيب Reagent B برضه على تلت الأنابيب
+
+447
+00:37:50,500 --> 00:37:56,560
+هحط واحد ملليلتر، واحد ملليلتر، واحد ملليلتر، وبعمل mix كويس
+
+448
+00:37:57,180 --> 00:38:00,660
+إذاً الـ kit هيكون فيه 2 Reagents، Reagent A و
+
+449
+00:38:00,660 --> 00:38:05,120
+Reagent B، بعد ما تحط Reagent B برضه بدك تعمل
+
+450
+00:38:05,120 --> 00:38:10,300
+Incubation عشر دقائق أو خمس دقائق على الـ water
+
+451
+00:38:10,300 --> 00:38:16,440
+bath، في الآخر بتسفري الجهاز على 600 نانومتر و بتضبطي
+
+452
+00:38:16,440 --> 00:38:20,320
+الـ wavelength على 600، بتسفري على الـ blank، بتحطي
+
+453
+00:38:20,320 --> 00:38:24,320
+الـ standard، تقرأي الـ absorbance تبعه، وبتجيبي
+
+454
+00:38:24,320 --> 00:38:27,400
+الصندل، بتحطيها في الكيوفيت، بتقرأي الـ absorbance
+
+455
+00:38:27,400 --> 00:38:32,900
+للصندل، وبتطبقي الـ Beer's law عشان تحسبي تركيز الـ
+
+456
+00:38:32,900 --> 00:38:37,820
+urea، طبعا هذا هنشتغله عملي لما نرجع الجامعة، هذه الـ
+
+457
+00:38:37,820 --> 00:38:43,960
+procedure بكل بساطة، الـ normal range لليوريا في
+
+458
+00:38:43,960 --> 00:38:49,280
+الجسم، الـ serum أو بلازما الإنسان الطبيعي، تركيز
+
+459
+00:38:49,280 --> 00:38:55,960
+اليوريا عنده من 6 لـ 20 مليجرام per deciliter، أن
+
+460
+00:38:55,960 --> 00:39:03,770
+اليوريا اللي في الـ urine خلال 24 ساعة، الإنسان لازم
+
+461
+00:39:03,770 --> 00:39:10,650
+يطلع من 12 لـ 20 جرام من اليوريا يوميا، لازم يطلعها
+
+462
+00:39:10,650 --> 00:39:17,050
+مع اليورين، إذا يوميا يطلع من 12 لـ 20 جرام من
+
+463
+00:39:17,050 --> 00:39:22,130
+اليوريا مع اليورين، هذا الـ normal range لليوريا في
+
+464
+00:39:22,130 --> 00:39:23,310
+الدم والبول
diff --git a/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/xPijAyn9v6I_raw.json b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/xPijAyn9v6I_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..ff0161d1e04201ffca6b9a8d10269baf6af020d9
--- /dev/null
+++ b/PL9fwy3NUQKwY0bmZLW1rkEOi8kDbDjjs7/xPijAyn9v6I_raw.json
@@ -0,0 +1 @@
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"end": 95.8, "text": "النيتروجين يحتوي على مصادر ليسوا بروتينات أو بوليبيبتات", "tokens": [6027, 1863, 36081, 2288, 29245, 9957, 7251, 33753, 45865, 15844, 3714, 9381, 18513, 2288, 32239, 3794, 14407, 4724, 32887, 31371, 8315, 2655, 34051, 4724, 12610, 1829, 21292, 3555, 2655, 9307], "avg_logprob": -0.4521169297156795, "compression_ratio": 1.2409638554216869, "no_speech_prob": 0.0, "words": [{"start": 89.84, "end": 90.74, "word": "النيتروجين", "probability": 0.709228515625}, {"start": 90.74, "end": 91.7, "word": " يحتوي", "probability": 0.6805013020833334}, {"start": 91.7, "end": 91.88, "word": " على", "probability": 0.8203125}, {"start": 91.88, "end": 92.68, "word": " مصادر", "probability": 0.40887451171875}, {"start": 92.68, "end": 93.76, "word": " ليسوا", "probability": 0.5737711588541666}, {"start": 93.76, "end": 94.62, "word": " بروتينات", "probability": 0.79404296875}, {"start": 94.62, "end": 94.88, "word": " أو", "probability": 0.92431640625}, {"start": 94.88, "end": 95.8, 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104.5, "end": 104.7, "word": " في", "probability": 0.951171875}, {"start": 104.7, "end": 105.42, "word": " تركيبها", "probability": 0.99072265625}, {"start": 105.42, "end": 106.06, "word": " الداخلي", "probability": 0.8369140625}, {"start": 106.06, "end": 106.9, "word": " لكن", "probability": 0.93310546875}, {"start": 106.9, "end": 107.34, "word": " هذه", "probability": 0.8740234375}, {"start": 107.34, "end": 107.9, "word": " المواد", "probability": 0.9697265625}, {"start": 107.9, "end": 108.34, "word": " لا", "probability": 0.849609375}, {"start": 108.34, "end": 108.98, "word": " تعتبر", "probability": 0.8507486979166666}, {"start": 108.98, "end": 109.8, "word": " proteins", "probability": 0.62255859375}, {"start": 109.8, "end": 110.24, "word": " أو", "probability": 0.7265625}, {"start": 110.24, "end": 111.12, "word": " polypeptides", "probability": 0.649261474609375}, {"start": 111.12, "end": 111.4, "word": " لا", "probability": 0.55615234375}, {"start": 111.4, "end": 111.96, "word": " تعتبر", "probability": 0.9407552083333334}, {"start": 111.96, "end": 112.26, "word": " من", "probability": 0.92919921875}, {"start": 112.26, "end": 112.84, "word": " ضمن", "probability": 0.9873046875}, {"start": 112.84, "end": 113.78, "word": " البروتينات", "probability": 0.86484375}, {"start": 113.78, "end": 114.8, "word": " useful", "probability": 0.392333984375}, {"start": 114.8, "end": 115.4, "word": " clinical", "probability": 0.92529296875}, {"start": 115.4, "end": 116.4, "word": " information", "probability": 0.90576171875}, {"start": 116.4, "end": 117.06, "word": " is", "probability": 0.92333984375}, {"start": 117.06, "end": 117.6, "word": " obtained", "probability": 0.943359375}, {"start": 117.6, "end": 117.98, "word": " from", "probability": 0.9267578125}, {"start": 117.98, "end": 118.82, "word": " individual", "probability": 0.94482421875}, {"start": 118.82, "end": 120.02, "word": " components", "probability": 0.92236328125}, {"start": 120.02, "end": 120.68, "word": " of", "probability": 0.95654296875}, {"start": 120.68, "end": 121.66, "word": " NPN", "probability": 0.88720703125}, {"start": 121.66, "end": 122.5, "word": " fraction", "probability": 0.76904296875}, {"start": 122.5, "end": 123.6, "word": " NPN", "probability": 0.791748046875}, {"start": 123.6, "end": 124.58, "word": " اختصار", "probability": 0.923828125}, {"start": 124.58, "end": 125.14, "word": " لـ", "probability": 0.785888671875}], "temperature": 1.0}, {"id": 7, "seek": 15280, "start": 125.72, "end": 152.8, "text": "Non-protein nitrogen fraction يقصد هنا إنه قياس تركيز هذه المواد الـ Non-protein nitrogen المواد اللي بتحتوي على نيترجن ولا تعتبر من البروتينات قياسها في بلازمة الدم بعطيني معلومات سريرية طبية جيدة من أجل التشريك على وظائف الكلاب", "tokens": [47914, 12, 1424, 1370, 259, 17903, 14135, 7251, 4587, 9381, 3215, 34105, 36145, 3224, 12174, 25528, 3794, 6055, 31747, 1829, 11622, 29538, 9673, 14407, 3215, 2423, 39184, 8774, 12, 1424, 1370, 259, 17903, 9673, 14407, 3215, 13672, 1829, 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المواد تحتوي في تركيبها على الـ nitrogen وهذه المواد أيضًا لا تعتبر من ضمن البروتينات", "tokens": [41185, 2423, 39184, 9339, 8717, 36178, 2423, 28820, 10943, 13672, 1829, 11331, 4117, 1829, 8315, 3224, 8978, 2423, 39184, 4137, 13672, 1829, 10874, 2304, 26895, 8717, 36081, 2288, 29245, 9957, 19273, 21810, 300, 366, 406, 15577, 420, 6754, 494, 662, 1875, 8978, 4724, 1211, 31377, 46007, 11778, 2304, 12399, 8978, 16472, 3215, 32640, 14407, 3215, 12399, 29538, 9673, 14407, 3215, 6055, 33753, 45865, 8978, 6055, 31747, 1829, 3555, 11296, 15844, 2423, 39184, 17903, 37037, 24192, 9673, 14407, 3215, 36632, 11242, 14111, 995, 20193, 6055, 34268, 26890, 9154, 48812, 27842, 2423, 26890, 35473, 9957, 9307], "avg_logprob": -0.19095394579987776, "compression_ratio": 1.6092436974789917, "no_speech_prob": 0.0, "words": [{"start": 154.4, "end": 154.64, "word": "في", "probability": 0.90869140625}, {"start": 154.64, "end": 154.84, "word": " الـ", "probability": 0.91943359375}, {"start": 154.84, "end": 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" compounds", "probability": 0.8876953125}, {"start": 162.0, "end": 162.6, "word": " that", "probability": 0.84765625}, {"start": 162.6, "end": 162.86, "word": " are", "probability": 0.92919921875}, {"start": 162.86, "end": 163.1, "word": " not", "probability": 0.90283203125}, {"start": 163.1, "end": 163.76, "word": " proteins", "probability": 0.87255859375}, {"start": 163.76, "end": 164.24, "word": " or", "probability": 0.70556640625}, {"start": 164.24, "end": 165.32, "word": " polypeptides", "probability": 0.8592529296875}, {"start": 165.32, "end": 165.56, "word": " في", "probability": 0.7802734375}, {"start": 165.56, "end": 166.2, "word": " بلازمة", "probability": 0.782470703125}, {"start": 166.2, "end": 166.7, "word": " دم،", "probability": 0.80810546875}, {"start": 166.7, "end": 166.8, "word": " في", "probability": 0.943359375}, {"start": 166.8, "end": 168.02, "word": " انديمواد،", "probability": 0.5852864583333334}, {"start": 168.02, "end": 168.28, "word": " هذه", "probability": 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357.36, "word": " والـUric", "probability": 0.80584716796875}, {"start": 357.36, "end": 358.3, "word": " Acid،", "probability": 0.6826985677083334}, {"start": 358.3, "end": 358.76, "word": " Major", "probability": 0.293212890625}, {"start": 358.76, "end": 359.84, "word": " executory", "probability": 0.6036376953125}, {"start": 359.84, "end": 360.76, "word": " product", "probability": 0.947265625}, {"start": 360.76, "end": 361.16, "word": " of", "probability": 0.96630859375}, {"start": 361.16, "end": 361.84, "word": " protein", "probability": 0.433349609375}, {"start": 361.84, "end": 363.38, "word": " metabolism،", "probability": 0.75634765625}, {"start": 363.38, "end": 363.92, "word": " مصدر", "probability": 0.99365234375}, {"start": 363.92, "end": 364.78, "word": " اليوريا،", "probability": 0.8359375}, {"start": 364.78, "end": 364.86, "word": " يا", "probability": 0.9814453125}, {"start": 364.86, "end": 365.94, "word": " جماعة،", "probability": 0.90185546875}, {"start": 365.94, "end": 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560.01, "end": 580.41, "text": "passively reabsorbed by the proximal retubules 40% من اليوريا الكلة بتعملها reabsorption بترجعها للدم و60% من اليوريا بيخرج كفضلات مع ال urine مع ال urine تمام؟", "tokens": [9216, 3413, 319, 17243, 284, 2883, 538, 264, 21932, 304, 1533, 836, 3473, 3356, 4, 9154, 45595, 13063, 25528, 2423, 28820, 3660, 39894, 25957, 1211, 11296, 319, 17243, 284, 1695, 39894, 47341, 3615, 11296, 24976, 40448, 4032, 4550, 4, 9154, 45595, 13063, 25528, 4724, 1829, 34740, 7435, 9122, 5172, 11242, 1211, 9307, 20449, 2423, 27638, 20449, 2423, 27638, 46811, 10943, 22807], "avg_logprob": -0.20640120919673674, "compression_ratio": 1.4125, "no_speech_prob": 2.980232238769531e-07, "words": [{"start": 560.01, "end": 560.71, "word": "passively", "probability": 0.5789794921875}, {"start": 560.71, "end": 561.81, "word": " reabsorbed", "probability": 0.91552734375}, {"start": 561.81, "end": 562.09, "word": " by", "probability": 0.85009765625}, {"start": 562.09, "end": 562.31, "word": " 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655.95, "word": " من", "probability": 0.99658203125}, {"start": 655.95, "end": 656.43, "word": " الـUrea", "probability": 0.9813232421875}, {"start": 656.43, "end": 657.75, "word": " بتنخرجها", "probability": 0.8619140625}, {"start": 657.75, "end": 658.11, "word": " مع", "probability": 0.83154296875}, {"start": 658.11, "end": 659.23, "word": " الـUrine،", "probability": 0.81865234375}, {"start": 659.23, "end": 659.43, "word": " مع", "probability": 0.98486328125}, {"start": 659.43, "end": 660.49, "word": " الفضلات،", "probability": 0.93603515625}, {"start": 660.49, "end": 660.93, "word": " تمام؟", "probability": 0.96533203125}], "temperature": 1.0}, {"id": 31, "seek": 67852, "start": 662.56, "end": 678.52, "text": "إذن اليوريا هي فضلات okay هي موجودة في الدم الكلب رجعت نسبة للدم يعني اليوريا موجودة بتركيز معين في الدم لكن أغلبها بيصير له excretion بخرج مع اليورين", "tokens": [28814, 8848, 1863, 45595, 13063, 25528, 39896, 6156, 11242, 1211, 9307, 1392, 39896, 3714, 29245, 23328, 3660, 8978, 32748, 2304, 2423, 28820, 3555, 12602, 7435, 34268, 8717, 35457, 3660, 24976, 40448, 37495, 22653, 45595, 13063, 25528, 3714, 29245, 23328, 3660, 39894, 31747, 1829, 11622, 20449, 9957, 8978, 32748, 2304, 44381, 5551, 17082, 46152, 11296, 4724, 1829, 9381, 13546, 46740, 1624, 1505, 313, 4724, 34740, 7435, 20449, 45595, 13063, 9957], "avg_logprob": -0.16595981674534935, "compression_ratio": 1.6560509554140128, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 662.56, "end": 663.06, "word": "إذن", "probability": 0.6818033854166666}, {"start": 663.06, "end": 663.68, "word": " اليوريا", "probability": 0.7975260416666666}, {"start": 663.68, "end": 663.9, "word": " هي", "probability": 0.90087890625}, {"start": 663.9, "end": 664.7, "word": " فضلات", "probability": 0.97998046875}, {"start": 664.7, "end": 665.48, "word": " okay", "probability": 0.2310791015625}, {"start": 665.48, "end": 665.86, "word": " هي", "probability": 0.72314453125}, {"start": 665.86, "end": 666.64, "word": " موجودة", "probability": 0.990478515625}, {"start": 666.64, "end": 666.76, "word": " في", "probability": 0.9814453125}, {"start": 666.76, "end": 667.12, "word": " الدم", "probability": 0.9873046875}, {"start": 667.12, "end": 667.72, "word": " الكلب", "probability": 0.7610677083333334}, {"start": 667.72, "end": 668.46, "word": " رجعت", "probability": 0.9383138020833334}, {"start": 668.46, "end": 668.98, "word": " نسبة", "probability": 0.9905598958333334}, {"start": 668.98, "end": 669.38, "word": " للدم", "probability": 0.76123046875}, {"start": 669.38, "end": 669.7, "word": " يعني", "probability": 0.926025390625}, {"start": 669.7, "end": 670.26, "word": " اليوريا", "probability": 0.9471028645833334}, {"start": 670.26, "end": 671.28, "word": " موجودة", "probability": 0.9901123046875}, {"start": 671.28, "end": 672.0, "word": " بتركيز", "probability": 0.9576416015625}, {"start": 672.0, "end": 672.54, "word": " معين", "probability": 0.988037109375}, {"start": 672.54, "end": 672.72, "word": " في", "probability": 0.9794921875}, {"start": 672.72, "end": 673.14, "word": " الدم", "probability": 0.98974609375}, {"start": 673.14, "end": 673.9, "word": " لكن", "probability": 0.92822265625}, {"start": 673.9, "end": 674.8, "word": " أغلبها", "probability": 0.993408203125}, {"start": 674.8, "end": 675.32, "word": " بيصير", "probability": 0.8895263671875}, {"start": 675.32, "end": 675.52, "word": " له", "probability": 0.359375}, {"start": 675.52, "end": 676.54, "word": " excretion", "probability": 0.7303059895833334}, {"start": 676.54, "end": 677.38, "word": " بخرج", "probability": 0.8873697916666666}, {"start": 677.38, "end": 677.82, "word": " مع", "probability": 0.95068359375}, {"start": 677.82, "end": 678.52, "word": " اليورين", "probability": 0.6190592447916666}], "temperature": 1.0}, {"id": 32, "seek": 70746, "start": 680.92, "end": 707.46, "text": "Blood urea levels can vary proportional with هلجيت يا جماعة بيحكيلي تركيز اليوريا في الدم مختلف وفي حالة اختلاف والتركيز بيختلف بناء على عدة عوانل أول عامل The protein content of the diet الأكل اللي أنت بتاكله جدش فيه بروتينات لو أنت أكلت أكل مليان بروتينات", "tokens": [33, 752, 378, 344, 12057, 4358, 393, 10559, 24969, 365, 8032, 1211, 7435, 36081, 35186, 10874, 15042, 27884, 4724, 1829, 5016, 4117, 1829, 20292, 6055, 31747, 1829, 11622, 45595, 13063, 25528, 8978, 32748, 2304, 3714, 46456, 46538, 4032, 41185, 11331, 6027, 3660, 1975, 46456, 15040, 5172, 16070, 2655, 31747, 1829, 11622, 4724, 1829, 46456, 46538, 44945, 16606, 15844, 6225, 41891, 6225, 2407, 7649, 1211, 5551, 12610, 6225, 10943, 1211, 440, 7944, 2701, 295, 264, 6339, 16247, 28820, 13672, 1829, 14739, 2655, 39894, 995, 28820, 3224, 10874, 3215, 8592, 8978, 3224, 4724, 32887, 2655, 9957, 9307, 45164, 14739, 2655, 5551, 28820, 2655, 5551, 28820, 3714, 20292, 7649, 4724, 32887, 2655, 9957, 9307], "avg_logprob": -0.1441127166950277, "compression_ratio": 1.6265060240963856, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 680.92, 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688.32, "word": " اليوريا", "probability": 0.727783203125}, {"start": 688.32, "end": 688.52, "word": " في", "probability": 0.93310546875}, {"start": 688.52, "end": 688.92, "word": " الدم", "probability": 0.9814453125}, {"start": 688.92, "end": 690.06, "word": " مختلف", "probability": 0.98681640625}, {"start": 690.06, "end": 691.54, "word": " وفي", "probability": 0.723876953125}, {"start": 691.54, "end": 692.16, "word": " حالة", "probability": 0.9977213541666666}, {"start": 692.16, "end": 692.94, "word": " اختلاف", "probability": 0.9461669921875}, {"start": 692.94, "end": 694.36, "word": " والتركيز", "probability": 0.87841796875}, {"start": 694.36, "end": 695.12, "word": " بيختلف", "probability": 0.98193359375}, {"start": 695.12, "end": 695.7, "word": " بناء", "probability": 0.976318359375}, {"start": 695.7, "end": 696.04, "word": " على", "probability": 0.83935546875}, {"start": 696.04, "end": 696.52, "word": " عدة", "probability": 0.988525390625}, {"start": 696.52, "end": 697.38, 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0.9864501953125}, {"start": 702.8, "end": 703.36, "word": " جدش", "probability": 0.6964518229166666}, {"start": 703.36, "end": 703.62, "word": " فيه", "probability": 0.98046875}, {"start": 703.62, "end": 704.22, "word": " بروتينات", "probability": 0.889453125}, {"start": 704.22, "end": 704.68, "word": " لو", "probability": 0.7490234375}, {"start": 704.68, "end": 704.98, "word": " أنت", "probability": 0.910400390625}, {"start": 704.98, "end": 705.5, "word": " أكلت", "probability": 0.97314453125}, {"start": 705.5, "end": 705.86, "word": " أكل", "probability": 0.94873046875}, {"start": 705.86, "end": 706.72, "word": " مليان", "probability": 0.9951171875}, {"start": 706.72, "end": 707.46, "word": " بروتينات", "probability": 0.94130859375}], "temperature": 1.0}, {"id": 33, "seek": 72692, "start": 707.84, "end": 726.92, "text": "يعني في الجسم هيصير تكسير لهذه البروتينات يعني تكسير للأحماض الأمينية معناه الأمونيا هتطلع كتيرة معناه اليوريا هتتكون بكميات أكبر يعني الأكل اللي أنت تاكله بحدد 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"end": 887.48, "text": "لو جينا فحصنا لهم اليوريا، هلاجي تركيزها عالي جدا، ليش؟ لأن الكلا واقف، عندهم ما بتشتغل، وبالتالي مش هتقدر تفلتر اليوريا، مش هتقدر تطلع اليوريا، هذه اليوريا فضلات، يفترض تطلع مع الـUrine، مين بتطلعها؟ الكلا", "tokens": [1211, 2407, 10874, 1829, 8315, 6156, 5016, 9381, 8315, 5296, 16095, 45595, 13063, 25528, 12399, 8032, 15040, 7435, 1829, 6055, 31747, 1829, 11622, 11296, 6225, 6027, 1829, 10874, 28259, 12399, 32239, 8592, 22807, 5296, 33456, 33251, 15040, 36764, 4587, 5172, 12399, 43242, 16095, 19446, 39894, 8592, 2655, 17082, 1211, 12399, 46599, 6027, 2655, 6027, 1829, 37893, 8032, 2655, 28543, 2288, 6055, 5172, 1211, 2655, 2288, 45595, 13063, 25528, 12399, 37893, 8032, 2655, 28543, 2288, 6055, 9566, 1211, 3615, 45595, 13063, 25528, 12399, 29538, 45595, 13063, 25528, 6156, 11242, 1211, 9307, 12399, 7251, 5172, 2655, 43042, 6055, 9566, 1211, 3615, 20449, 2423, 39184, 52, 15140, 12399, 3714, 9957, 39894, 9566, 1211, 3615, 11296, 22807, 33251, 15040], 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"end": 1487.83, "word": " لأنه", "probability": 0.77490234375}, {"start": 1487.83, "end": 1487.97, "word": " لو", "probability": 0.966796875}, {"start": 1487.97, "end": 1488.87, "word": " استخدمته", "probability": 0.9556884765625}, {"start": 1488.87, "end": 1490.21, "word": " هيصبت", "probability": 0.693359375}, {"start": 1490.21, "end": 1491.31, "word": " الـUrea's", "probability": 0.781396484375}, {"start": 1491.31, "end": 1492.11, "word": " reaction", "probability": 0.8642578125}, {"start": 1492.11, "end": 1493.33, "word": " هيصبت", "probability": 0.9063720703125}, {"start": 1493.33, "end": 1494.05, "word": " التفاعل", "probability": 0.9486083984375}, {"start": 1494.05, "end": 1494.53, "word": " اللي", "probability": 0.97705078125}, {"start": 1494.53, "end": 1495.27, "word": " هيصير", "probability": 0.8123372395833334}, {"start": 1495.27, "end": 1495.83, "word": " ما", "probability": 0.92822265625}, {"start": 1495.83, "end": 1496.11, "word": " بين", "probability": 0.99609375}, {"start": 1496.11, "end": 1497.25, "word": " الـReagent", "probability": 0.79423828125}, {"start": 1497.25, "end": 1497.59, "word": " تبع", "probability": 0.9563802083333334}, {"start": 1497.59, "end": 1498.13, "word": " اليوريا", "probability": 0.85009765625}, {"start": 1498.13, "end": 1498.85, "word": " وما", "probability": 0.931640625}, {"start": 1498.85, "end": 1499.19, "word": " بين", "probability": 0.9970703125}, {"start": 1499.19, "end": 1500.03, "word": " اليوريا", "probability": 0.9713541666666666}, {"start": 1500.03, "end": 1500.59, "word": " اللي", "probability": 0.94287109375}, {"start": 1500.59, "end": 1501.27, "word": " موجودة", "probability": 0.99267578125}, {"start": 1501.27, "end": 1501.71, "word": " في", "probability": 0.9482421875}, {"start": 1501.71, "end": 1502.67, "word": " الـPlasma", "probability": 0.797802734375}, {"start": 1502.67, "end": 1502.99, "word": " تاعت", "probability": 0.7316080729166666}, {"start": 1502.99, "end": 1503.57, "word": " المريض", "probability": 0.9191080729166666}, {"start": 1503.57, "end": 1504.53, "word": " Therefore,", "probability": 0.354736328125}, {"start": 1505.15, "end": 1505.65, "word": " methods", "probability": 0.54833984375}, {"start": 1505.65, "end": 1506.77, "word": " employing", "probability": 0.947265625}, {"start": 1506.77, "end": 1507.75, "word": " Urea's", "probability": 0.7089029947916666}, {"start": 1507.75, "end": 1508.17, "word": " cannot", "probability": 0.390625}, {"start": 1508.17, "end": 1508.75, "word": " use", "probability": 0.88623046875}, {"start": 1508.75, "end": 1509.43, "word": " serum", "probability": 0.70654296875}, {"start": 1509.43, "end": 1510.59, "word": " preserved", "probability": 0.9365234375}, {"start": 1510.59, "end": 1511.01, "word": " with", "probability": 0.923828125}, {"start": 1511.01, "end": 1511.71, "word": " fluoride", "probability": 0.815185546875}], "temperature": 1.0}, {"id": 69, "seek": 154029, "start": 1511.79, "end": 1540.29, "text": "عشان هيك ممنوع استخدام الـ Anticoagulant Fluoride لأنه هيصبت التفاعل اللي هيصير ما بين عينات المريض والـ Reagent تبع اليوريا أيضا الـ Ammonium Heparin هذا الـ Anticoagulant برضه ممنوع استخدامه تمام؟ في طريقة الـUries Methods هذه إحدى الطرق اللي بنشتغل فيها فحص اليوريا", "tokens": [3615, 8592, 7649, 39896, 4117, 3714, 27842, 45367, 44713, 9778, 3215, 10943, 2423, 39184, 5130, 2789, 559, 425, 394, 33612, 284, 482, 5296, 33456, 3224, 39896, 9381, 3555, 2655, 16712, 5172, 995, 30241, 13672, 1829, 39896, 9381, 13546, 19446, 49374, 6225, 1829, 8315, 2655, 9673, 16572, 11242, 16070, 39184, 1300, 559, 317, 6055, 3555, 3615, 45595, 13063, 25528, 36632, 11242, 995, 2423, 39184, 2012, 3317, 2197, 634, 2181, 259, 23758, 2423, 39184, 5130, 2789, 559, 425, 394, 4724, 43042, 3224, 3714, 27842, 45367, 44713, 9778, 3215, 10943, 3224, 46811, 10943, 22807, 8978, 23032, 16572, 28671, 2423, 39184, 52, 2244, 25285, 82, 29538, 11933, 24401, 7578, 41950, 2288, 4587, 13672, 1829, 44945, 8592, 2655, 17082, 1211, 8978, 11296, 6156, 5016, 9381, 45595, 13063, 25528], "avg_logprob": -0.17174899073377733, "compression_ratio": 1.6384615384615384, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 1511.79, "end": 1512.35, "word": "عشان", "probability": 0.9449869791666666}, {"start": 1512.35, "end": 1512.95, "word": " هيك", "probability": 0.939453125}, {"start": 1512.95, "end": 1513.41, "word": " ممنوع", "probability": 0.7449544270833334}, {"start": 1513.41, "end": 1514.03, "word": " استخدام", "probability": 0.7685546875}, {"start": 1514.03, "end": 1514.27, "word": " الـ", "probability": 0.958984375}, {"start": 1514.27, "end": 1515.11, "word": " Anticoagulant", "probability": 0.8921875}, {"start": 1515.11, "end": 1515.83, "word": " Fluoride", "probability": 0.7202962239583334}, {"start": 1515.83, "end": 1516.59, "word": " لأنه", "probability": 0.8447265625}, {"start": 1516.59, "end": 1517.57, "word": " هيصبت", "probability": 0.7799072265625}, {"start": 1517.57, "end": 1518.41, "word": " التفاعل", "probability": 0.9530029296875}, {"start": 1518.41, "end": 1518.99, "word": " اللي", "probability": 0.93603515625}, {"start": 1518.99, "end": 1519.67, "word": " هيصير", "probability": 0.7584635416666666}, {"start": 1519.67, "end": 1520.25, "word": " ما", "probability": 0.94189453125}, {"start": 1520.25, "end": 1520.51, "word": " بين", "probability": 0.99658203125}, {"start": 1520.51, "end": 1521.35, "word": " عينات", "probability": 0.77117919921875}, {"start": 1521.35, "end": 1521.89, "word": " المريض", "probability": 0.9822591145833334}, {"start": 1521.89, "end": 1522.29, "word": " والـ", "probability": 0.8095703125}, {"start": 1522.29, "end": 1522.89, "word": " Reagent", "probability": 0.6875813802083334}, {"start": 1522.89, "end": 1523.33, "word": " تبع", "probability": 0.9581705729166666}, {"start": 1523.33, "end": 1524.11, "word": " اليوريا", "probability": 0.8758138020833334}, {"start": 1524.11, "end": 1525.19, "word": " أيضا", "probability": 0.79150390625}, {"start": 1525.19, "end": 1525.75, "word": " الـ", "probability": 0.83056640625}, {"start": 1525.75, "end": 1526.39, "word": " Ammonium", "probability": 0.9352213541666666}, {"start": 1526.39, "end": 1526.95, "word": " Heparin", "probability": 0.7865397135416666}, {"start": 1526.95, "end": 1527.49, "word": " هذا", "probability": 0.69775390625}, {"start": 1527.49, "end": 1527.83, "word": " الـ", "probability": 0.9599609375}, {"start": 1527.83, "end": 1528.87, "word": " Anticoagulant", "probability": 0.97255859375}, {"start": 1528.87, "end": 1529.69, "word": " برضه", "probability": 0.9444986979166666}, {"start": 1529.69, "end": 1530.47, "word": " ممنوع", "probability": 0.8839518229166666}, {"start": 1530.47, "end": 1532.41, "word": " استخدامه", "probability": 0.98193359375}, {"start": 1532.41, "end": 1533.73, "word": " تمام؟", "probability": 0.8582356770833334}, {"start": 1533.73, "end": 1533.89, "word": " في", "probability": 0.8994140625}, {"start": 1533.89, "end": 1534.59, "word": " طريقة", "probability": 0.9913736979166666}, {"start": 1534.59, "end": 1535.37, "word": " الـUries", "probability": 0.5778045654296875}, {"start": 1535.37, "end": 1536.39, "word": " Methods", "probability": 0.5594482421875}, {"start": 1536.39, "end": 1536.63, "word": " هذه", "probability": 0.775390625}, {"start": 1536.63, "end": 1537.31, "word": " إحدى", "probability": 0.8683268229166666}, {"start": 1537.31, "end": 1537.87, "word": " الطرق", "probability": 0.9754231770833334}, {"start": 1537.87, "end": 1538.11, "word": " اللي", "probability": 0.9423828125}, {"start": 1538.11, "end": 1538.75, "word": " بنشتغل", "probability": 0.97431640625}, {"start": 1538.75, "end": 1539.07, "word": " فيها", "probability": 0.99267578125}, {"start": 1539.07, "end": 1539.61, "word": " فحص", "probability": 0.9671223958333334}, {"start": 1539.61, "end": 1540.29, "word": " اليوريا", "probability": 0.9697265625}], "temperature": 1.0}, {"id": 70, "seek": 155708, "start": 1540.94, "end": 1557.08, "text": "لأنه يا جماعة الـUrea حكينا هي عبارة عن أمونيا و CO2 لو كسرنا الـUrea بإنزايم الـUrease هيطلع أمونيا و CO2 فانت لو استخدمت الـAmmonium-Hibarin", "tokens": [1211, 33456, 3224, 35186, 10874, 15042, 27884, 2423, 39184, 52, 12057, 11331, 4117, 1829, 8315, 39896, 6225, 3555, 9640, 3660, 18871, 5551, 2304, 11536, 25528, 4032, 3002, 17, 45164, 9122, 3794, 2288, 8315, 2423, 39184, 52, 12057, 4724, 28814, 1863, 11622, 995, 32640, 2423, 39184, 52, 265, 651, 39896, 9566, 1211, 3615, 5551, 2304, 11536, 25528, 4032, 3002, 17, 6156, 7649, 2655, 45164, 44713, 9778, 40448, 2655, 2423, 39184, 16833, 3317, 2197, 12, 39, 897, 289, 259], "avg_logprob": -0.1954126556714376, "compression_ratio": 1.40625, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 1540.94, "end": 1541.46, "word": "لأنه", "probability": 0.7285970052083334}, {"start": 1541.46, "end": 1541.56, "word": " يا", "probability": 0.92724609375}, {"start": 1541.56, "end": 1542.16, "word": " جماعة", "probability": 0.9889322916666666}, {"start": 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{"start": 1550.24, "end": 1551.1, "word": " الـUrease", "probability": 0.8182861328125}, {"start": 1551.1, "end": 1552.04, "word": " هيطلع", "probability": 0.8099365234375}, {"start": 1552.04, "end": 1552.64, "word": " أمونيا", "probability": 0.9825439453125}, {"start": 1552.64, "end": 1552.84, "word": " و", "probability": 0.9765625}, {"start": 1552.84, "end": 1553.46, "word": " CO2", "probability": 0.900634765625}, {"start": 1553.46, "end": 1554.34, "word": " فانت", "probability": 0.77001953125}, {"start": 1554.34, "end": 1554.52, "word": " لو", "probability": 0.9833984375}, {"start": 1554.52, "end": 1555.32, "word": " استخدمت", "probability": 0.842041015625}, {"start": 1555.32, "end": 1556.32, "word": " الـAmmonium", "probability": 0.86650390625}, {"start": 1556.32, "end": 1557.08, "word": "-Hibarin", "probability": 0.64228515625}], "temperature": 1.0}, {"id": 71, "seek": 158119, "start": 1557.71, "end": 1581.19, "text": "الـ Ammonium هذا الـ Anticoagulant لو اتكسّر هيعطيني أمونيا برضه وبالتالي هيك تركيز الأمونيا هالزيت في العينة وبدّيش أنا مؤثرات خارجي يتأثر على الـ reaction تبع الفحث إذن الـ Ammonium-Heparin ممنوع كـ Anticoagulant ممنوع استخدمه لأنه فيه أمونيام", "tokens": [6027, 39184, 2012, 3317, 2197, 23758, 2423, 39184, 5130, 2789, 559, 425, 394, 45164, 1975, 2655, 4117, 3794, 11703, 2288, 39896, 3615, 9566, 1829, 22653, 5551, 2304, 11536, 25528, 4724, 43042, 3224, 46599, 6027, 2655, 6027, 1829, 39896, 4117, 6055, 31747, 1829, 11622, 16247, 2304, 11536, 25528, 8032, 6027, 11622, 36081, 8978, 18863, 9957, 3660, 4032, 44510, 11703, 1829, 8592, 41850, 3714, 33604, 12984, 2288, 9307, 16490, 9640, 7435, 1829, 7251, 2655, 10721, 49115, 15844, 2423, 39184, 5480, 6055, 3555, 3615, 27188, 5016, 12984, 11933, 8848, 1863, 2423, 39184, 2012, 3317, 2197, 12, 39, 595, 19829, 3714, 27842, 45367, 9122, 39184, 5130, 2789, 559, 425, 394, 3714, 27842, 45367, 44713, 9778, 40448, 3224, 5296, 33456, 3224, 8978, 3224, 5551, 2304, 11536, 1829, 10943], "avg_logprob": 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9381], "avg_logprob": -0.23267045942219822, "compression_ratio": 1.3571428571428572, "no_speech_prob": 0.0, "words": [{"start": 1581.98, "end": 1582.38, "word": "والـ", "probability": 0.8702799479166666}, {"start": 1582.38, "end": 1583.0, "word": " Reaction", "probability": 0.654296875}, {"start": 1583.0, "end": 1583.58, "word": " نفسه", "probability": 0.9744466145833334}, {"start": 1583.58, "end": 1583.72, "word": " اللي", "probability": 0.941650390625}, {"start": 1583.72, "end": 1584.36, "word": " هيصير", "probability": 0.6630859375}, {"start": 1584.36, "end": 1585.1, "word": " هيكون", "probability": 0.661865234375}, {"start": 1585.1, "end": 1585.38, "word": " فيه", "probability": 0.97998046875}, {"start": 1585.38, "end": 1585.96, "word": " أمونيا", "probability": 0.909423828125}, {"start": 1585.96, "end": 1586.1, "word": " و", "probability": 0.468994140625}, {"start": 1586.1, "end": 1586.9, "word": " أمونيام", "probability": 0.7724609375}, {"start": 1586.9, "end": 1587.1, "word": " و", "probability": 0.95263671875}, {"start": 1587.1, "end": 1587.7, "word": " يوريا", "probability": 0.8082682291666666}, {"start": 1587.7, "end": 1588.24, "word": " تمام", "probability": 0.97509765625}, {"start": 1588.24, "end": 1588.72, "word": " ثماب", "probability": 0.634765625}, {"start": 1588.72, "end": 1589.0, "word": " الـ", "probability": 0.89453125}, {"start": 1589.0, "end": 1589.28, "word": " DA", "probability": 0.1466064453125}, {"start": 1589.28, "end": 1590.48, "word": " مؤثرات", "probability": 0.835693359375}, {"start": 1590.48, "end": 1591.0, "word": " خارجية", "probability": 0.9952392578125}, {"start": 1591.0, "end": 1591.54, "word": " تأثر", "probability": 0.9197591145833334}, {"start": 1591.54, "end": 1591.78, "word": " على", "probability": 0.94091796875}, {"start": 1591.78, "end": 1592.4, "word": " الفحص", "probability": 0.9405924479166666}], "temperature": 1.0}, {"id": 73, "seek": 161868, "start": 1594.04, "end": 1618.68, "text": "الـ susceptibility بتاعة السيرم و البلازمة بيضلوا سبع أيام في التلاجة و بيضلهم سنة محفوظين في الـ freezer because of urea susceptibility to bacterial degradation سيرم and urine samples should be kept at أربعة لتمانية درجة ثلجية until analysis يا جماعة العينة سيرم أو بلازمة أو urine", "tokens": [6027, 39184, 26104, 2841, 39894, 995, 27884, 21136, 13546, 2304, 4032, 29739, 1211, 31377, 46007, 4724, 1829, 11242, 1211, 14407, 8608, 3555, 3615, 36632, 10943, 8978, 16712, 1211, 26108, 3660, 4032, 4724, 1829, 11242, 1211, 16095, 8608, 1863, 3660, 3714, 5016, 5172, 2407, 19913, 9957, 8978, 2423, 39184, 20189, 570, 295, 344, 12057, 26104, 2841, 281, 35632, 40519, 8608, 13546, 2304, 293, 27638, 10938, 820, 312, 4305, 412, 5551, 25513, 27884, 5296, 39237, 7649, 10632, 11778, 47341, 3660, 38637, 1211, 7435, 10632, 1826, 5215, 35186, 10874, 15042, 27884, 18863, 9957, 3660, 8608, 13546, 2304, 34051, 4724, 1211, 31377, 46007, 34051, 27638], "avg_logprob": -0.2221201000844731, "compression_ratio": 1.604, "no_speech_prob": 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1605.28, "end": 1605.94, "word": " bacterial", "probability": 0.79296875}, {"start": 1605.94, "end": 1606.84, "word": " degradation", "probability": 0.95361328125}, {"start": 1606.84, "end": 1607.82, "word": " سيرم", "probability": 0.810302734375}, {"start": 1607.82, "end": 1608.14, "word": " and", "probability": 0.75537109375}, {"start": 1608.14, "end": 1608.48, "word": " urine", "probability": 0.95458984375}, {"start": 1608.48, "end": 1609.2, "word": " samples", "probability": 0.87744140625}, {"start": 1609.2, "end": 1609.76, "word": " should", "probability": 0.9775390625}, {"start": 1609.76, "end": 1610.18, "word": " be", "probability": 0.958984375}, {"start": 1610.18, "end": 1610.64, "word": " kept", "probability": 0.8828125}, {"start": 1610.64, "end": 1611.04, "word": " at", "probability": 0.751953125}, {"start": 1611.04, "end": 1611.64, "word": " أربعة", "probability": 0.7086588541666666}, {"start": 1611.64, "end": 1612.3, "word": " لتمانية", "probability": 0.895263671875}, {"start": 1612.3, "end": 1612.72, "word": " درجة", "probability": 0.9876302083333334}, {"start": 1612.72, "end": 1613.34, "word": " ثلجية", "probability": 0.52178955078125}, {"start": 1613.34, "end": 1613.88, "word": " until", "probability": 0.931640625}, {"start": 1613.88, "end": 1614.54, "word": " analysis", "probability": 0.79736328125}, {"start": 1614.54, "end": 1615.24, "word": " يا", "probability": 0.87646484375}, {"start": 1615.24, "end": 1615.82, "word": " جماعة", "probability": 0.9947916666666666}, {"start": 1615.82, "end": 1616.6, "word": " العينة", "probability": 0.7599283854166666}, {"start": 1616.6, "end": 1617.06, "word": " سيرم", "probability": 0.97216796875}, {"start": 1617.06, "end": 1617.4, "word": " أو", "probability": 0.93603515625}, {"start": 1617.4, "end": 1618.06, "word": " بلازمة", "probability": 0.9129638671875}, {"start": 1618.06, "end": 1618.42, "word": " أو", "probability": 0.91650390625}, {"start": 1618.42, "end": 1618.68, "word": " urine", "probability": 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"probability": 0.99462890625}, {"start": 1628.16, "end": 1628.6, "word": " urine", "probability": 0.97509765625}, {"start": 1628.6, "end": 1629.82, "word": " سواء", "probability": 0.970703125}, {"start": 1629.82, "end": 1630.24, "word": " urine", "probability": 0.97412109375}, {"start": 1630.24, "end": 1630.76, "word": " أو", "probability": 0.8359375}, {"start": 1630.76, "end": 1631.34, "word": " سيرم", "probability": 0.730712890625}, {"start": 1631.34, "end": 1632.52, "word": " يفضل", "probability": 0.9544677734375}, {"start": 1632.52, "end": 1633.36, "word": " نحفظ", "probability": 0.9906005859375}, {"start": 1633.36, "end": 1634.0, "word": " العينة", "probability": 0.9583333333333334}, {"start": 1634.0, "end": 1634.12, "word": " في", "probability": 0.9765625}, {"start": 1634.12, "end": 1634.8, "word": " التلاجة", "probability": 0.985107421875}, {"start": 1634.8, "end": 1635.04, "word": " ما", "probability": 0.79736328125}, {"start": 1635.04, "end": 1635.68, "word": " نتركها", "probability": 0.973876953125}, {"start": 1635.68, "end": 1636.18, "word": " على", "probability": 0.94482421875}, {"start": 1636.18, "end": 1636.42, "word": " الـ", "probability": 0.69775390625}, {"start": 1636.42, "end": 1636.58, "word": " room", "probability": 0.90869140625}, {"start": 1636.58, "end": 1637.14, "word": " temperature", "probability": 0.94921875}], "temperature": 1.0}, {"id": 75, "seek": 165213, "start": 1637.77, "end": 1652.13, "text": "لأن لو عينة الـ Urine أو عينة السيرم انتركت برا ممكن تتلوث ببكتيريا، bacterial contamination طب ما تتلوث في البكتيريا، إيش هتعمل البكتيريا؟ كل كوا أخدته في الـ micro organism", "tokens": [1211, 33456, 45164, 6225, 9957, 3660, 2423, 39184, 9533, 533, 34051, 6225, 9957, 3660, 21136, 13546, 2304, 16472, 2655, 31747, 2655, 4724, 23557, 3714, 43020, 6055, 2655, 1211, 2407, 12984, 4724, 3555, 4117, 2655, 13546, 25528, 12399, 35632, 33012, 23032, 3555, 19446, 6055, 2655, 1211, 2407, 12984, 8978, 29739, 4117, 2655, 13546, 25528, 12399, 11933, 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"end": 2351.83, "word": " اليورين", "probability": 0.80712890625}, {"start": 2351.83, "end": 2352.41, "word": " إذا", "probability": 0.67724609375}, {"start": 2352.41, "end": 2353.11, "word": " يوميا", "probability": 0.9827473958333334}, {"start": 2353.11, "end": 2354.05, "word": " يطلع", "probability": 0.685546875}, {"start": 2354.05, "end": 2354.17, "word": " من", "probability": 0.75634765625}, {"start": 2354.17, "end": 2355.09, "word": " 12", "probability": 0.84619140625}, {"start": 2355.09, "end": 2355.53, "word": " ل", "probability": 0.94921875}, {"start": 2355.53, "end": 2355.99, "word": " 20", "probability": 0.62939453125}, {"start": 2355.99, "end": 2356.59, "word": " جرام", "probability": 0.9825846354166666}, {"start": 2356.59, "end": 2357.05, "word": " من", "probability": 0.94677734375}, {"start": 2357.05, "end": 2358.01, "word": " اليوريا", "probability": 0.9664713541666666}, {"start": 2358.01, "end": 2358.67, "word": " مع", "probability": 0.98046875}, {"start": 2358.67, "end": 2359.41, "word": " اليورين", "probability": 0.9754231770833334}, {"start": 2359.41, "end": 2359.79, "word": " هذا", "probability": 0.6943359375}, {"start": 2359.79, "end": 2360.39, "word": " الـnormal", "probability": 0.3956705729166667}, {"start": 2360.39, "end": 2361.07, "word": " range", "probability": 0.91796875}, {"start": 2361.07, "end": 2361.83, "word": " لليوريا", "probability": 0.801025390625}, {"start": 2361.83, "end": 2362.13, "word": " في", "probability": 0.96044921875}, {"start": 2362.13, "end": 2362.43, "word": " الدم", "probability": 0.923828125}, {"start": 2362.43, "end": 2363.31, "word": " واليورين", "probability": 0.888427734375}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2364.975625, "duration_after_vad": 2325.4312499999955}
\ No newline at end of file
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/-KFnjmJFb28_raw.srt b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/-KFnjmJFb28_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..a20b9e9f6944eb1dd11161cc5fdefa9a55fd254c
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/-KFnjmJFb28_raw.srt
@@ -0,0 +1,1528 @@
+1
+00:00:20,960 --> 00:00:25,440
+Okay good morning to you again how are you good
+
+2
+00:00:25,440 --> 00:00:29,260
+it's nice to start with a smile now look
+
+3
+00:00:29,260 --> 00:00:33,800
+expressions of quantity some of expresses what
+
+4
+00:00:33,800 --> 00:00:39,400
+quantity right a lot of expresses quantity two
+
+5
+00:00:39,400 --> 00:00:44,120
+thirds of most of they express what they express
+
+6
+00:00:44,120 --> 00:00:48,320
+quantity okay now these expressions of quantity
+
+7
+00:00:49,270 --> 00:00:53,950
+don't determine what type of verb should be used
+
+8
+00:00:53,950 --> 00:00:59,890
+after them now listen it is singular if you have a
+
+9
+00:00:59,890 --> 00:01:03,990
+singular noun look at book it is singular
+
+10
+00:01:03,990 --> 00:01:11,130
+equipment okay moneyhomework okay now we used a
+
+11
+00:01:11,130 --> 00:01:15,290
+singular noun and a singular verb now look the
+
+12
+00:01:15,290 --> 00:01:18,670
+same amounts the same words the same expressions
+
+13
+00:01:18,670 --> 00:01:23,590
+some of a lot of and so on what did we use after
+
+14
+00:01:23,590 --> 00:01:28,070
+them plural nouns good and after the plural nouns
+
+15
+00:01:28,070 --> 00:01:33,380
+okay good what do you understandwho can't tell me؟
+
+16
+00:01:33,380 --> 00:01:36,060
+what do you understand؟ نعم مارواه with
+
+17
+00:01:36,060 --> 00:01:41,160
+expressions of quantity we use the singular verbs
+
+18
+00:01:41,160 --> 00:01:46,040
+when we use singular noun but use plural verb when
+
+19
+00:01:46,040 --> 00:01:48,680
+we use plural nounThank you very much. So with
+
+20
+00:01:48,680 --> 00:01:52,100
+expressions of a quantity, we can use plural and
+
+21
+00:01:52,100 --> 00:01:56,220
+singular. If a plural noun is used, we use a
+
+22
+00:01:56,220 --> 00:01:59,960
+plural verb. Singular, we need what? Singular.
+
+23
+00:02:00,300 --> 00:02:04,060
+Okay, read please. In most expressions of
+
+24
+00:02:04,060 --> 00:02:09,760
+quantity, the verb is determined by the noun or
+
+25
+00:02:09,760 --> 00:02:15,900
+pronoun that I follow of for example كم أsome of
+
+26
+00:02:15,900 --> 00:02:19,780
+singular nouns is singular verbs some of plural
+
+27
+00:02:19,780 --> 00:02:27,460
+nouns is plural verbs okay thank you now look one
+
+28
+00:02:27,460 --> 00:02:34,780
+of my friends one of my friends each of my friends
+
+29
+00:02:34,780 --> 00:02:41,260
+do you remember when we talked about each okay now
+
+30
+00:02:41,260 --> 00:02:43,380
+yeah each
+
+31
+00:02:48,350 --> 00:02:54,790
+student has okay each student has every student
+
+32
+00:02:54,790 --> 00:03:07,590
+have now if I say each of each of students each
+
+33
+00:03:07,590 --> 00:03:09,110
+of the students
+
+34
+00:03:12,820 --> 00:03:19,620
+has okay each of the students has look now what's
+
+35
+00:03:19,620 --> 00:03:25,780
+the difference each between each and each of yes
+
+36
+00:03:25,780 --> 00:03:31,880
+please very good that's right thank you very much
+
+37
+00:03:31,880 --> 00:03:34,880
+this is followed by a singular noun and that is
+
+38
+00:03:34,880 --> 00:03:38,280
+followed by a plural noun now look at the examples
+
+39
+00:03:45,250 --> 00:03:51,290
+look at the examples now one of my friends is this
+
+40
+00:03:51,290 --> 00:03:58,690
+is what plural and this is singular okay my each
+
+41
+00:03:58,690 --> 00:04:03,930
+of my friends plural and singular every one of my
+
+42
+00:04:03,930 --> 00:04:09,490
+friends okay now look this is singular and this is
+
+43
+00:04:09,490 --> 00:04:15,460
+plural what does the rule saywhat does the rule
+
+44
+00:04:15,460 --> 00:04:20,960
+say؟ the general rule of subject-verb agreement
+
+45
+00:04:20,960 --> 00:04:25,680
+plural verbs go
+
+46
+00:04:25,680 --> 00:04:33,220
+with pluralnouns and singular with singular okay
+
+47
+00:04:33,220 --> 00:04:36,940
+plural with plural and singular with singular now
+
+48
+00:04:36,940 --> 00:04:39,680
+what about this what can you see this is singular
+
+49
+00:04:39,680 --> 00:04:43,780
+and this is plural this is what singular and
+
+50
+00:04:43,780 --> 00:04:47,720
+plural and this is what okay and this is what this
+
+51
+00:04:47,720 --> 00:04:53,110
+is an exception okay this is an exception yeahOkay
+
+52
+00:04:53,110 --> 00:04:57,270
+read it one of each of and every and every one of
+
+53
+00:04:57,270 --> 00:04:59,650
+are followed by plural nouns and take singular
+
+54
+00:04:59,650 --> 00:05:02,790
+verbs thank you very much this is an exception to
+
+55
+00:05:02,790 --> 00:05:11,670
+the rule okay any question now
+
+56
+00:05:11,670 --> 00:05:20,090
+none of the boys is here none of the boys and none
+
+57
+00:05:20,090 --> 00:05:25,240
+of the boys arenone of the boys is and none of the
+
+58
+00:05:25,240 --> 00:05:29,260
+boys are subject with none of used to be
+
+59
+00:05:29,260 --> 00:05:33,700
+considered singular this is in the past they used
+
+60
+00:05:33,700 --> 00:05:37,940
+it in the past now it is not used okay used to be
+
+61
+00:05:37,940 --> 00:05:43,800
+I used to drive her fastit means I'm not driving
+
+62
+00:05:43,800 --> 00:05:47,620
+fast now I stopped right she used to come late
+
+63
+00:05:47,620 --> 00:05:51,620
+she's not coming late now she stopped okay so they
+
+64
+00:05:51,620 --> 00:05:55,580
+used to be considered what singular in very formal
+
+65
+00:05:55,580 --> 00:06:00,000
+English but plural verbs are often used in okay
+
+66
+00:06:00,000 --> 00:06:04,240
+and sometimes even informal writing so informal
+
+67
+00:06:04,240 --> 00:06:08,440
+writing we use what the plural okay informal
+
+68
+00:06:08,440 --> 00:06:15,560
+writing we use the plural pluralالان في هذه
+
+69
+00:06:15,560 --> 00:06:19,820
+الدراسة في
+
+70
+00:06:19,820 --> 00:06:26,880
+هذه الدراسة نحن لدينا سبنتين طلاب حسنًا، هذا هو
+
+71
+00:06:26,880 --> 00:06:34,900
+الرقم الوضعي، الرقم الوضعي، لذلك نقول رقم الطلاب
+
+72
+00:06:41,520 --> 00:06:46,920
+in this class is what we
+
+73
+00:06:46,920 --> 00:06:50,340
+are talking about today how many students one two
+
+74
+00:06:50,340 --> 00:06:55,840
+it is about sixty five we have sixty five out of
+
+75
+00:06:55,840 --> 00:07:02,360
+seventy okay so the number of students is what
+
+76
+00:07:02,360 --> 00:07:09,120
+does that mean it means that a number of
+
+77
+00:07:09,120 --> 00:07:10,980
+students
+
+78
+00:07:12,910 --> 00:07:17,190
+a number
+
+79
+00:07:17,190 --> 00:07:24,730
+of students are absent now the number is a number
+
+80
+00:07:24,730 --> 00:07:31,250
+are okay now we used what plural noun and plural
+
+81
+00:07:31,250 --> 00:07:37,170
+noun so we have two expressions be careful about
+
+82
+00:07:37,170 --> 00:07:39,930
+the number of and a number of
+
+83
+00:07:44,890 --> 00:07:48,710
+look at this example please read the number of
+
+84
+00:07:48,710 --> 00:07:51,370
+students in the class is fifteen yeah the number
+
+85
+00:07:51,370 --> 00:07:55,070
+is fifteen now this is what this is the subject
+
+86
+00:07:55,070 --> 00:07:58,670
+good go on a number of students were late for
+
+87
+00:07:58,670 --> 00:08:03,480
+class okay a number of it means a lot ofالكثير من
+
+88
+00:08:03,480 --> 00:08:06,220
+الطلاب كانوا هناك والكثير من الطلاب كانوا هناك
+
+89
+00:08:06,220 --> 00:08:11,300
+لذلك لدينا اتصالات اتصالات اتصالات اتصالات اتصالات
+
+90
+00:08:11,300 --> 00:08:15,080
+اتصالات اتصالات اتصالات اتصالات اتصالات اتصالات
+
+91
+00:08:15,080 --> 00:08:15,720
+اتصالات اتصالات اتصالات اتصالات اتصالات اتصالات
+
+92
+00:08:15,720 --> 00:08:16,200
+اتصالات اتصالات اتصالات اتصالات اتصالات اتصالات
+
+93
+00:08:16,200 --> 00:08:17,300
+اتصالات اتصالات اتصالات اتصالات اتصالات اتصالات
+
+94
+00:08:17,300 --> 00:08:18,520
+اتصالات اتصالات اتصالات اتصالات اتصالات اتصالات
+
+95
+00:08:18,520 --> 00:08:29,340
+اتصالات اتصالات اتصالات اتصال
+
+96
+00:08:31,950 --> 00:08:35,690
+look at your box all of you دعا what do you read
+
+97
+00:08:35,690 --> 00:08:41,030
+number one some
+
+98
+00:08:41,030 --> 00:08:48,590
+of the fruit in this bowl is rotten okay this is
+
+99
+00:08:48,590 --> 00:08:58,490
+done number two some of the apples are rottensome
+
+100
+00:08:58,490 --> 00:09:01,910
+of the apples are very good thank you very much
+
+101
+00:09:01,910 --> 00:09:07,790
+next one yes please number three most of read it
+
+102
+00:09:07,790 --> 00:09:12,090
+yeah most of the movie is good thank you next one
+
+103
+00:09:12,090 --> 00:09:17,590
+thank
+
+104
+00:09:17,590 --> 00:09:21,540
+you very much good next one yes pleasehalf of the
+
+105
+00:09:21,540 --> 00:09:23,920
+students in the class are from Arabic speaking
+
+106
+00:09:23,920 --> 00:09:27,180
+countries you are right half of the students are
+
+107
+00:09:27,180 --> 00:09:32,820
+good yes please next half of this money is .. yes
+
+108
+00:09:32,820 --> 00:09:35,820
+half of this money is thank you very much yes
+
+109
+00:09:35,820 --> 00:09:38,700
+please a lot of students in the class are from
+
+110
+00:09:38,700 --> 00:09:41,840
+southern Asia good thank you very much next one
+
+111
+00:09:41,840 --> 00:09:45,320
+please yeah a lot of the .. a lot of the clothing
+
+112
+00:09:45,320 --> 00:09:48,620
+industrial stores is on .. you are right thank you
+
+113
+00:09:48,620 --> 00:09:49,820
+very much yes please
+
+114
+00:09:53,780 --> 00:09:58,720
+one of my best friends is one is okay thank you
+
+115
+00:09:58,720 --> 00:10:05,880
+yes each boy has very good thank you yes please
+
+116
+00:10:05,880 --> 00:10:11,020
+yeah which
+
+117
+00:10:11,020 --> 00:10:18,780
+one you are doing number eleven each of the boys
+
+118
+00:10:20,190 --> 00:10:26,150
+has okay each of the boys has thank you twelve yes
+
+119
+00:10:26,150 --> 00:10:31,930
+please okay
+
+120
+00:10:31,930 --> 00:10:36,330
+thank you every one of the students is yes please
+
+121
+00:10:36,330 --> 00:10:41,690
+none of the animals are
+
+122
+00:10:41,690 --> 00:10:42,430
+okay
+
+123
+00:10:51,620 --> 00:10:57,580
+Okay thank you so none of the animals are free all
+
+124
+00:10:57,580 --> 00:11:06,140
+of them are okay thank you yes please a number are
+
+125
+00:11:06,140 --> 00:11:11,400
+good thank you yes is
+
+126
+00:11:11,400 --> 00:11:13,800
+the number is thank you very much yes please
+
+127
+00:11:39,710 --> 00:11:45,590
+ماذا لو كان بعض الطلاب ..
+
+128
+00:11:49,040 --> 00:11:51,800
+Okay thank you very much why was one of the
+
+129
+00:11:51,800 --> 00:11:59,040
+students okay now look what about there what do
+
+130
+00:11:59,040 --> 00:12:05,500
+you have in your bag marwa there is a sandwich in
+
+131
+00:12:05,500 --> 00:12:11,440
+her bag there are some box in her bag okay what do
+
+132
+00:12:11,440 --> 00:12:18,290
+you have in your bag khadija there isthere is a
+
+133
+00:12:18,290 --> 00:12:23,190
+book there is a grammar book okay and thank you
+
+134
+00:12:23,190 --> 00:12:26,130
+yeah what do you have in your bag please there is
+
+135
+00:12:26,130 --> 00:12:32,630
+a wallet good what do you have in your bag please
+
+136
+00:12:32,630 --> 00:12:44,950
+there there there start with there there is a
+
+137
+00:12:44,950 --> 00:12:50,560
+mobilesay it again there is a mobile thank you
+
+138
+00:12:50,560 --> 00:12:54,220
+very much yes what do you have in your bag there
+
+139
+00:12:54,220 --> 00:12:56,920
+is some money thank you yes what do you have in
+
+140
+00:12:56,920 --> 00:13:02,700
+your bag there is okay there
+
+141
+00:13:02,700 --> 00:13:06,300
+is a piece of chocolate thank you good yes what do
+
+142
+00:13:06,300 --> 00:13:09,880
+you have in your bagthere are a lot of things
+
+143
+00:13:09,880 --> 00:13:15,320
+thank you very much now look there is a fly this
+
+144
+00:13:15,320 --> 00:13:19,120
+is singular and this is singular there are three
+
+145
+00:13:19,120 --> 00:13:23,640
+windows there are three windows now are can be
+
+146
+00:13:23,640 --> 00:13:30,300
+followed bysingular and singular or plural and
+
+147
+00:13:30,300 --> 00:13:36,700
+plural as you see what determines the noun is the
+
+148
+00:13:36,700 --> 00:13:40,120
+verb the verb determines the type of noun whether
+
+149
+00:13:40,120 --> 00:13:45,820
+we need a singular or a plural one now there is
+
+150
+00:13:45,820 --> 00:13:49,560
+two sides to every story this is informal but it
+
+151
+00:13:49,560 --> 00:13:52,700
+is used in everyday language okay
+
+152
+00:13:57,880 --> 00:14:01,380
+نريد أن نقوم بعمل عملية 14، أرجوك، انظر إلى الكتاب
+
+153
+00:14:01,380 --> 00:14:08,420
+الخاص بك عملية 14، مرة أخرى، رقم 1، قرأها لا يوجد
+
+154
+00:14:08,420 --> 00:14:13,960
+أي كلمات أو
+
+155
+00:14:13,960 --> 00:14:16,260
+لا يوجد أي كلمات أو لا يوجد أي كلمات أو لا يوجد أي
+
+156
+00:14:16,260 --> 00:14:16,260
+كلمات أو لا يوجد أي كلمات أو لا يوجد أي كلمات أو
+
+157
+00:14:16,260 --> 00:14:16,420
+لا يوجد أي كلمات أو لا يوجد أي كلمات أو لا يوجد أي
+
+158
+00:14:16,420 --> 00:14:22,220
+كلمات أو لا يوجد أي كلمات أو لا يوجد أي كلمات أو
+
+159
+00:14:22,220 --> 00:14:24,140
+لا يوجد أي كلمات أو لا يوجد أي كلمات أو لا يوجد أي
+
+160
+00:14:24,140 --> 00:14:24,140
+كلمات أو لا يوجد أي كلمات أو لا يوجد أي كلمات أو
+
+161
+00:14:24,140 --> 00:14:24,140
+لا يوجد أي كلمات أو لا يوجد أي كلمات أو لا يوجد أي
+
+162
+00:14:24,140 --> 00:14:29,570
+كلمات أو لا يالعديد من المشاكل، جيد، أجل، أرجوك
+
+163
+00:14:29,570 --> 00:14:34,550
+هناك مخطط في المصعد، حسنًا، جيد، هناك مخطط، شكرا،
+
+164
+00:14:34,550 --> 00:14:39,670
+أجل، أرجوك، كم نوع من الحيوانات موجودة هناك؟ كم
+
+165
+00:14:39,670 --> 00:14:42,550
+نوع من الحيوانات موجودة هناك؟ شكرا، أجل، أجل، أجل،
+
+166
+00:14:42,550 --> 00:14:52,010
+أجل، أجل، أجل، أجل، أجل، أجل، أجل،
+
+167
+00:14:52,010 --> 00:14:52,090
+أجل، أجل، أجل، أجل، أجل، أجل، أجل، أجل، أجل، أجل،
+
+168
+00:14:52,090 --> 00:14:52,850
+أجل، أجل، أجل، أجل، أجل، أجل، أجل، أجل، أجل، أجل،
+
+169
+00:14:52,850 --> 00:14:52,870
+أجل، أ
+
+170
+00:14:56,310 --> 00:14:59,070
+there was a terrible .. you are right .. a
+
+171
+00:14:59,070 --> 00:15:02,470
+terrible earthquake .. yes please go on why is
+
+172
+00:15:02,470 --> 00:15:07,050
+there a shortage of apartments .. thank you .. why
+
+173
+00:15:07,050 --> 00:15:11,910
+.. which .. yeah this is number eight .. why .. is
+
+174
+00:15:11,910 --> 00:15:15,670
+there a shortage .. a shortage .. this is what ..
+
+175
+00:15:15,670 --> 00:15:18,110
+singular .. yes please go on و لا
+
+176
+00:15:22,720 --> 00:15:26,060
+there are more women than men okay in my office
+
+177
+00:15:26,060 --> 00:15:31,600
+thank you good and next one yes please there
+
+178
+00:15:31,600 --> 00:15:40,600
+listen
+
+179
+00:15:40,600 --> 00:15:45,240
+there a line a line this is singular please wait
+
+180
+00:15:45,240 --> 00:15:48,600
+wait yeah what do you think why did you use have
+
+181
+00:15:48,600 --> 00:15:55,320
+how many linesone so with one we use has thank you
+
+182
+00:15:55,320 --> 00:16:05,160
+good next one very good thank you very much now
+
+183
+00:16:05,160 --> 00:16:15,960
+look the united states the united states is is big
+
+184
+00:16:15,960 --> 00:16:21,630
+the united arab emirates is a big countryThe
+
+185
+00:16:21,630 --> 00:16:26,230
+United Arab Emirates is a big country look it ends
+
+186
+00:16:26,230 --> 00:16:31,730
+with s but it takes what singular verb now if you
+
+187
+00:16:31,730 --> 00:16:35,070
+want to use a pronoun instead of the united states
+
+188
+00:16:35,070 --> 00:16:40,850
+do we use it or they it so it what it is big it is
+
+189
+00:16:40,850 --> 00:16:46,660
+big okay now the philippinesconsists the country
+
+190
+00:16:46,660 --> 00:16:54,600
+consists it consists the united nations has
+
+191
+00:16:54,600 --> 00:17:01,860
+okay has the organization has it has okay harrods
+
+192
+00:17:01,860 --> 00:17:05,880
+is a department store harrods is like in Gaza
+
+193
+00:17:05,880 --> 00:17:13,360
+let's say steps you know steps steps what is steps
+
+194
+00:17:14,640 --> 00:17:20,100
+yes what is it it is a big mall a big supermarket
+
+195
+00:17:20,100 --> 00:17:24,040
+in النصر street okay so this is the name of the
+
+196
+00:17:24,040 --> 00:17:27,980
+store this is the name of the store okay this is
+
+197
+00:17:27,980 --> 00:17:33,600
+the name so we say steps is or steps are steps is
+
+198
+00:17:33,600 --> 00:17:41,050
+okay a big steps is a big store steps is okayالان
+
+199
+00:17:41,050 --> 00:17:49,490
+نفس الشيء هاروز هذا اسم المزارع هاروز is الان انظر
+
+200
+00:17:49,490 --> 00:17:56,510
+هذه ال nouns تنتهي ب S لكنهم يأخذون ما؟ كلمة
+
+201
+00:17:56,510 --> 00:18:01,350
+مفعولة هم يتحدثون عن كلمة مفعولة ليس ككلمة مفعولة
+
+202
+00:18:01,350 --> 00:18:05,150
+الحوار
+
+203
+00:18:05,150 --> 00:18:07,990
+هو مهما
+
+204
+00:18:09,990 --> 00:18:13,410
+the news is interesting the furniture is new
+
+205
+00:18:13,410 --> 00:18:20,790
+mathematics is easy look this ends with s and
+
+206
+00:18:20,790 --> 00:18:27,210
+takes singular verb the news is mathematics this
+
+207
+00:18:27,210 --> 00:18:31,770
+is a field of study a topic for study phonetics is
+
+208
+00:18:31,770 --> 00:18:37,210
+linguistics is okayphysics is again when we talk
+
+209
+00:18:37,210 --> 00:18:40,850
+about fields of study because it is one topic okay
+
+210
+00:18:40,850 --> 00:18:46,730
+one subject we use a singular verb okay now look
+
+211
+00:18:46,730 --> 00:18:56,210
+at this the apetezia isan illness is an illness it
+
+212
+00:18:56,210 --> 00:19:00,130
+ends with s but it is one disease okay again
+
+213
+00:19:00,130 --> 00:19:04,550
+measles ends with what s so these names of
+
+214
+00:19:04,550 --> 00:19:08,130
+diseases though they end with s but they show what
+
+215
+00:19:08,130 --> 00:19:14,950
+singular nouns they express one we say it it
+
+216
+00:19:14,950 --> 00:19:20,870
+causes it has it makes and so on they are singular
+
+217
+00:19:20,870 --> 00:19:21,350
+ones
+
+218
+00:19:24,980 --> 00:19:32,900
+now eight hours of sleep is
+
+219
+00:19:32,900 --> 00:19:39,800
+enough this period of time is enough okay eight
+
+220
+00:19:39,800 --> 00:19:43,320
+hours of sleep this is a period it is one period
+
+221
+00:19:43,320 --> 00:19:47,960
+so this period is what enough singular yeah read
+
+222
+00:19:47,960 --> 00:19:49,960
+the other one please yes
+
+223
+00:19:53,090 --> 00:19:58,090
+it is too much this sum this amount of money is
+
+224
+00:19:58,090 --> 00:20:01,390
+what is too much to pay thank you read the other
+
+225
+00:20:01,390 --> 00:20:02,070
+one please
+
+226
+00:20:05,900 --> 00:20:11,320
+miles is five thousand miles okay this is distance
+
+227
+00:20:11,320 --> 00:20:15,560
+it is one distance okay one distance so this
+
+228
+00:20:15,560 --> 00:20:19,540
+expresses a distance expresses amount of money a
+
+229
+00:20:19,540 --> 00:20:23,680
+sum of money and a period of time so with these we
+
+230
+00:20:23,680 --> 00:20:29,840
+use what we use singular verbs thank you now look
+
+231
+00:20:29,840 --> 00:20:37,170
+at these mathematical expressions two and twois
+
+232
+00:20:37,170 --> 00:20:43,250
+far two and two is or two and two equals two plus
+
+233
+00:20:43,250 --> 00:20:46,430
+two okay five
+
+234
+00:20:48,850 --> 00:20:55,930
+five times five okay five times five is what
+
+235
+00:20:55,930 --> 00:21:00,670
+twenty five now with these arithmetic expressions
+
+236
+00:21:00,670 --> 00:21:06,090
+what type of verb did we use singular so with
+
+237
+00:21:06,090 --> 00:21:10,750
+arithmetic expressions we use what singular verbs
+
+238
+00:21:10,750 --> 00:21:19,790
+thank you those people are those people arepeople
+
+239
+00:21:19,790 --> 00:21:25,110
+are yes please read the other one have the police
+
+240
+00:21:25,110 --> 00:21:34,490
+have have the policeman has okay yeah cattle are
+
+241
+00:21:35,750 --> 00:21:43,530
+cattle are domestic animals and fish live fish
+
+242
+00:21:43,530 --> 00:21:48,570
+live okay it takes a plural verb they take plural
+
+243
+00:21:48,570 --> 00:21:54,890
+verb are cattle are fish live and so on yeah read
+
+244
+00:21:54,890 --> 00:21:56,630
+the note please
+
+245
+00:22:05,280 --> 00:22:09,640
+very good they require plural plural plural verbs
+
+246
+00:22:09,640 --> 00:22:16,880
+okay now look English is spoken in many countries
+
+247
+00:22:16,880 --> 00:22:22,920
+and the English drink tea it is the same word but
+
+248
+00:22:22,920 --> 00:22:26,200
+the meaning is different now English we mean what
+
+249
+00:22:26,990 --> 00:22:31,470
+اللغة جيدًا جدًا لذلك اللغة الإنقليزية لديها لغة
+
+250
+00:22:31,470 --> 00:22:36,350
+إنقليزية لديها لغة إنقليزية لديها لغة انقليزية
+
+251
+00:22:36,350 --> 00:22:36,390
+لديها لغة انقليزية لديها لغة انقليزية لديها لغة
+
+252
+00:22:36,390 --> 00:22:39,310
+انقليزية لديها لغة انقليزية لديها لغة انقليزية
+
+253
+00:22:39,310 --> 00:22:40,650
+لديها لغة انقليزية لديها لغة انقليزية لديها لغة
+
+254
+00:22:40,650 --> 00:22:41,010
+انقليزية لديها لغة انقليزية لديها لغة انقليزية
+
+255
+00:22:41,010 --> 00:22:46,090
+لديها لغة انقليزية لديها لغة انقليزية لديها لغة
+
+256
+00:22:46,090 --> 00:22:54,530
+انقليزية لديها لغة انقليزية لديها لغة انقليزية
+
+257
+00:22:55,560 --> 00:23:00,360
+people people okay live in china thank you that's
+
+258
+00:23:00,360 --> 00:23:07,840
+right now some words can okay some words can be
+
+259
+00:23:07,840 --> 00:23:13,540
+used or express a language or it have some words
+
+260
+00:23:13,540 --> 00:23:15,960
+have more than one meaning if they express a
+
+261
+00:23:15,960 --> 00:23:20,260
+language a language is English is we use a
+
+262
+00:23:20,260 --> 00:23:22,980
+singular verb but if they express the people the
+
+263
+00:23:22,980 --> 00:23:36,350
+nationality okaynow some nouns read please yeah
+
+264
+00:23:36,350 --> 00:23:41,050
+French for example French is and the French are
+
+265
+00:23:41,050 --> 00:23:45,270
+okay go on English, Spanish, Chinese, Japanese,
+
+266
+00:23:45,550 --> 00:23:54,050
+Vietnamese Portuguese okay thank you now the poor
+
+267
+00:23:54,050 --> 00:23:54,810
+have money
+
+268
+00:24:02,140 --> 00:24:08,740
+الفقراء الفقراء الفقراء الفقراء الفقراء الفقراء
+
+269
+00:24:08,740 --> 00:24:08,740
+الفقراء الفقراء الفقراء الفقراء الفقراء الفقراء
+
+270
+00:24:08,740 --> 00:24:10,760
+الفقراء الفقراء الفقراء الفقراء الفقراء الفقراء
+
+271
+00:24:10,760 --> 00:24:15,000
+الفقراء الفقراء الفقراء الفقراء الفقراء الفقراء
+
+272
+00:24:15,000 --> 00:24:18,060
+الفقراء الفقراء الفقراء الفقراء الفقراء الفقراء
+
+273
+00:24:18,060 --> 00:24:20,640
+الفقراء الفقراء الفقراء الفقراء الفقراء الفقراء
+
+274
+00:24:20,640 --> 00:24:24,680
+الفقراء الفقراء الفقراء الفقراءالان قوموا بقراءة
+
+275
+00:24:24,680 --> 00:24:34,760
+المقالات بالفعل
+
+276
+00:24:53,570 --> 00:24:56,870
+Okay thank you the disabled people who are
+
+277
+00:24:56,870 --> 00:25:02,570
+disabled the deaf people who are deaf people who
+
+278
+00:25:02,570 --> 00:25:08,410
+are blind and so on okay any question look at your
+
+279
+00:25:08,410 --> 00:25:14,290
+book please page 94 let's do the exercise
+
+280
+00:25:22,730 --> 00:25:28,210
+نمبر واحد نعم أرجوك الولايات المتحدة لديها ..
+
+281
+00:25:28,210 --> 00:25:31,270
+الولايات المتحدة لديها .. قولها مرة أخرى ..
+
+282
+00:25:31,270 --> 00:25:35,410
+الولايات المتحدة لديها .. قولها مرة أخرى ..
+
+283
+00:25:35,410 --> 00:25:35,490
+الولايات المتحدة لديها .. قولها مرة أخرى ..
+
+284
+00:25:35,490 --> 00:25:36,770
+الولايات المتحدة لديها .. قولها مرة أخرى ..
+
+285
+00:25:36,770 --> 00:25:39,890
+الولايات المتحدة لديها .. قولها مرة أخرى ..
+
+286
+00:25:39,890 --> 00:25:42,690
+الولايات المتحدة لديها .. قولها مرة أخرى ..
+
+287
+00:25:42,690 --> 00:25:43,510
+الولايات المتحدة لديها .. قولها مرة أخرى ..
+
+288
+00:25:43,510 --> 00:25:47,290
+الولايات المتحدة لديها .. قولها مرة أخرى ..
+
+289
+00:25:47,290 --> 00:25:47,290
+الولايات المتحدة لديها .. قولها مرة أخرى ..
+
+290
+00:25:47,290 --> 00:25:49,790
+الولايات المتحدة لديها ..Okay the news is very
+
+291
+00:25:49,790 --> 00:25:54,570
+good thank you the news is thank you yeah next one
+
+292
+00:25:54,570 --> 00:25:59,430
+okay
+
+293
+00:25:59,430 --> 00:26:02,930
+thank you very much the new york times this is a
+
+294
+00:26:02,930 --> 00:26:07,630
+newspaper the new york times is thank you yes
+
+295
+00:26:07,630 --> 00:26:10,190
+please next one physics again
+
+296
+00:26:15,920 --> 00:26:20,540
+please one speaker please one speaker yeah seek or
+
+297
+00:26:20,540 --> 00:26:27,000
+seeks please one speaker one speaker please yeah
+
+298
+00:26:27,000 --> 00:26:32,540
+physics it is singular okay what is physics it is
+
+299
+00:26:32,540 --> 00:26:36,980
+a topic of study okay it is like linguistics we
+
+300
+00:26:36,980 --> 00:26:43,620
+say linguistics is or are is okay go on physics
+
+301
+00:26:43,620 --> 00:26:48,600
+seeks thank you yes pleasefamily is a branch of
+
+302
+00:26:48,600 --> 00:26:55,300
+mathematics statistics is okay complete the
+
+303
+00:26:55,300 --> 00:27:00,800
+sentence a branch of mathematics okay this is the
+
+304
+00:27:00,800 --> 00:27:01,940
+study thank you yeah
+
+305
+00:27:07,680 --> 00:27:12,900
+Okay now look in number five statistics this is
+
+306
+00:27:12,900 --> 00:27:18,500
+the science okay but in number six the statistics
+
+307
+00:27:18,500 --> 00:27:24,160
+in the report you
+
+308
+00:27:24,160 --> 00:27:27,400
+are right thank you yes
+
+309
+00:27:34,270 --> 00:27:38,850
+yes fifty minutes is or are is fifty minutes is
+
+310
+00:27:38,850 --> 00:27:46,530
+good thank you next one unreasonable
+
+311
+00:27:46,530 --> 00:27:50,890
+price Nicholas
+
+312
+00:27:50,890 --> 00:27:55,470
+thank you many people in the world don't have
+
+313
+00:27:55,470 --> 00:27:59,810
+enough to eat many people don't have very good
+
+314
+00:27:59,810 --> 00:28:01,470
+thank you yes please
+
+315
+00:28:09,480 --> 00:28:21,200
+again you are right thank you the police are thank
+
+316
+00:28:21,200 --> 00:28:27,140
+you this is a type of disease yeah thank
+
+317
+00:28:27,140 --> 00:28:29,600
+you the French are what do you mean by the French
+
+318
+00:28:29,600 --> 00:28:33,680
+here nationality or people or language very good
+
+319
+00:28:33,680 --> 00:28:33,840
+yes
+
+320
+00:28:37,110 --> 00:28:41,270
+yes thank you this is the language French isn't my
+
+321
+00:28:41,270 --> 00:28:48,130
+native language yes ولا thank you
+
+322
+00:28:48,130 --> 00:28:51,930
+very much many Japanese commute okay thank you
+
+323
+00:28:51,930 --> 00:28:59,550
+next one yeah okay
+
+324
+00:28:59,550 --> 00:29:02,730
+thank you very much okay this is the language
+
+325
+00:29:02,730 --> 00:29:06,250
+right and Spanish is what the language yeah next
+
+326
+00:29:06,250 --> 00:29:12,820
+onethe poor are helped by the government thank you
+
+327
+00:29:12,820 --> 00:29:17,000
+the poor are helped thank you good next one yes
+
+328
+00:29:17,000 --> 00:29:21,440
+please the blind want the rest of us to treat them
+
+329
+00:29:21,440 --> 00:29:25,440
+the same way we treat everyone else thank you very
+
+330
+00:29:25,440 --> 00:29:30,080
+much the blind want thank want the blind want good
+
+331
+00:29:30,080 --> 00:29:36,100
+okay go on next one yes marwaالفرق بين حرية الحرس
+
+332
+00:29:36,100 --> 00:29:40,300
+والإيمان على الإنسان يعتمد على نفس الشخص الذي
+
+333
+00:29:40,300 --> 00:29:47,860
+يعتمد على حرس الحرس. الكثير من الناس ليسوا في خطر
+
+334
+00:29:47,860 --> 00:29:53,640
+في وقتهم، ولكن هناك حالات اتفاقية كبيرة. حسنًا،
+
+335
+00:29:53,640 --> 00:30:00,320
+شكرا جدًا، جيد، أنت محق، شكرا. الأن، اتأكد من أنك
+
+336
+00:30:00,320 --> 00:30:06,200
+حصلت على الإجابات الصحيحة، تفقد إجابتك بسرعةبسرعة
+
+337
+00:30:06,200 --> 00:30:11,260
+اتفقنا بإجابتك ودعونا
+
+338
+00:30:11,260 --> 00:30:16,820
+نعمل نصيحة لدراسة هذه الدراسة دعونا نعمل نصيحة
+
+339
+00:30:16,820 --> 00:30:21,140
+لدراسة هذه الدراسة ماذا تحدثنا عنه اليوم؟ اتفقنا
+
+340
+00:30:21,140 --> 00:30:29,380
+بإذن الله نعم أرجوك بعض الكثير و بعض الاسباب
+
+341
+00:30:29,380 --> 00:30:36,850
+من القطةإذا كان الـ f of تتبع من نوع محدد،
+
+342
+00:30:36,850 --> 00:30:40,270
+فسنستخدم الفعل المحدد، إذا كان الـ f of محدد،
+
+343
+00:30:40,270 --> 00:30:43,790
+فسنستخدم الفعل المحدد، إذا كان الـ f of محدد،
+
+344
+00:30:43,790 --> 00:30:50,510
+فسنستخدم الفعل المحدد،
+
+345
+00:30:50,510 --> 00:30:56,770
+إذا كان الـ f of محدد،
+
+346
+00:30:56,770 --> 00:30:59,410
+فسنستخدم الفعل المحدد، إذا كان الOkay and they are
+
+347
+00:30:59,410 --> 00:31:02,230
+an exception to the rule okay thank you because
+
+348
+00:31:02,230 --> 00:31:04,950
+they take plural nouns and singular verbs thank
+
+349
+00:31:04,950 --> 00:31:09,770
+you okay
+
+350
+00:31:09,770 --> 00:31:16,450
+subjects okay they are singular nouns they take
+
+351
+00:31:16,450 --> 00:31:22,370
+singular verbs yes please very
+
+352
+00:31:22,370 --> 00:31:29,970
+good for example we say twoand two is four good
+
+353
+00:31:29,970 --> 00:31:32,670
+two and four is two is four yeah
+
+354
+00:31:39,090 --> 00:31:43,090
+Okay thank you so some words express a language
+
+355
+00:31:43,090 --> 00:31:48,630
+okay English is easy this is the language but when
+
+356
+00:31:48,630 --> 00:31:52,430
+we say the English people who are from England
+
+357
+00:31:52,430 --> 00:31:56,810
+okay the English are the English like yeah
+
+358
+00:32:04,710 --> 00:32:11,530
+Okay thank you very much good yes please plural
+
+359
+00:32:11,530 --> 00:32:17,270
+nouns
+
+360
+00:32:17,270 --> 00:32:20,490
+you are right the poor are the blind are good
+
+361
+00:32:20,490 --> 00:32:27,530
+thank you the rich are thank you yeah okay
+
+362
+00:32:27,530 --> 00:32:31,210
+you
+
+363
+00:32:31,210 --> 00:32:37,470
+are rightlike okay some types of diseases names of
+
+364
+00:32:37,470 --> 00:32:42,010
+illnesses end with s but they take singular verb
+
+365
+00:32:42,010 --> 00:32:47,830
+yeah yeah
+
+366
+00:32:47,830 --> 00:32:53,190
+don't end with s okay
+
+367
+00:32:53,190 --> 00:32:58,510
+people is for people are sorry yeah yeah they
+
+368
+00:32:58,510 --> 00:33:05,130
+don't end with s but they take plural yeahثم ينتهي
+
+369
+00:33:05,130 --> 00:33:09,010
+بـ
+
+370
+00:33:09,010 --> 00:33:12,710
+S مثلا الولايات المتحدة بالعربية الولايات المتحدة
+
+371
+00:33:12,710 --> 00:33:13,650
+بالعربية الولايات المتحدة بالعربية الولايات
+
+372
+00:33:13,650 --> 00:33:14,550
+المتحدة بالعربية الولايات المتحدة بالعربية
+
+373
+00:33:14,550 --> 00:33:14,550
+الولايات المتحدة بالعربية الولايات المتحدة
+
+374
+00:33:14,550 --> 00:33:15,350
+بالعربية الولايات المتحدة بالعربية الولايات
+
+375
+00:33:15,350 --> 00:33:15,350
+المتحدة بالعربية الولايات المتحدة بالعربية
+
+376
+00:33:15,350 --> 00:33:15,370
+الولايات المتحدة بالعربية الولايات المتحدة
+
+377
+00:33:15,370 --> 00:33:18,750
+بالعربية الولايات المتحدة بالعربية الولايات
+
+378
+00:33:18,750 --> 00:33:18,850
+المتحدة بالعربية الولايات المتحدة بالعربية
+
+379
+00:33:18,850 --> 00:33:22,030
+الولايات المتحدة بالعربية الولايات المتحدة
+
+380
+00:33:22,030 --> 00:33:25,250
+بالعربية الولايات المتحدة بال
+
+381
+00:33:28,220 --> 00:33:32,600
+Okay in plural writing we use our .. okay thank
+
+382
+00:33:32,600 --> 00:33:33,680
+you very much for today
+
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/2w2N8Ojjp24_postprocess.srt b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/2w2N8Ojjp24_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..f8d33a230400bb9a1130395d8ab529ad0f89d3e0
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/2w2N8Ojjp24_postprocess.srt
@@ -0,0 +1,1636 @@
+1
+00:00:20,700 --> 00:00:26,180
+السلام عليكم. Good morning to you all. Let's start
+
+2
+00:00:26,180 --> 00:00:29,160
+with a smile since you finished your exams. So
+
+3
+00:00:29,160 --> 00:00:33,960
+smile to each other. Okay. We started talking
+
+4
+00:00:33,960 --> 00:00:39,340
+about pronouns. We had some exercises. I'm afraid
+
+5
+00:00:39,340 --> 00:00:44,020
+everything has gone with the exams. Let's revise
+
+6
+00:00:44,020 --> 00:00:47,770
+quickly the personal pronouns.الـ personal
+
+7
+00:00:47,770 --> 00:00:52,130
+pronouns الان ماذا كنت تقول عن الجمهور الأول؟ نعم،
+
+8
+00:00:52,130 --> 00:00:57,910
+قرأ و أقول، نعم، حنين ماذا
+
+9
+00:00:57,910 --> 00:01:03,270
+يعني subject pronouns؟ لا،
+
+10
+00:01:03,270 --> 00:01:12,510
+لا تترجم، اعني ماذا تعرف عن هذه الpronouns؟ تعال،
+
+11
+00:01:12,510 --> 00:01:18,330
+تعال، تعالyou mean they are used as the subject of
+
+12
+00:01:18,330 --> 00:01:23,030
+the sentence or they refer to the subject good
+
+13
+00:01:23,030 --> 00:01:26,710
+they refer to the subject or they are used as the
+
+14
+00:01:26,710 --> 00:01:30,310
+subject this group is singular and this group is
+
+15
+00:01:30,310 --> 00:01:35,950
+plural thank you yeah sorry I know I know but just
+
+16
+00:01:35,950 --> 00:01:39,850
+we I want to remind you because we need it in some
+
+17
+00:01:39,850 --> 00:01:43,650
+exercises now yeah what you tell me about the
+
+18
+00:01:43,650 --> 00:01:49,690
+other groupyes please object pronoun me you her
+
+19
+00:01:49,690 --> 00:01:56,890
+him it we use object pronoun as a object in the
+
+20
+00:01:56,890 --> 00:02:00,070
+sentence okay they are used as the object of the
+
+21
+00:02:00,070 --> 00:02:05,410
+sentence or as the .. they refer to the object so
+
+22
+00:02:05,410 --> 00:02:10,610
+they are used as the object or refer to the object
+
+23
+00:02:10,610 --> 00:02:15,540
+orOkay object of the preposition very good khadija
+
+24
+00:02:15,540 --> 00:02:20,160
+they are they can this is for him okay this is for
+
+25
+00:02:20,160 --> 00:02:24,020
+me this is for you can be used as the object of
+
+26
+00:02:24,020 --> 00:02:26,920
+the preposition they visited me yesterday they
+
+27
+00:02:26,920 --> 00:02:30,880
+visited me this is the object this is for you this
+
+28
+00:02:30,880 --> 00:02:34,460
+is object of the preposition good and what about
+
+29
+00:02:34,460 --> 00:02:37,860
+the other group what about the other group yes
+
+30
+00:02:37,860 --> 00:02:42,950
+pleaseبصوت ال pronouns mine, yours, his, its and
+
+31
+00:02:42,950 --> 00:02:46,650
+in plural ours, yours, theirs aren't .. this
+
+32
+00:02:46,650 --> 00:02:49,390
+pronouns aren't followed by noun؟ yeah they are
+
+33
+00:02:49,390 --> 00:02:53,050
+not followed by nouns I say this is mine this is
+
+34
+00:02:53,050 --> 00:02:56,490
+yours this is ours and so on so they are they can
+
+35
+00:02:56,490 --> 00:03:00,290
+stand alone and they should not be followed by a
+
+36
+00:03:00,290 --> 00:03:03,370
+noun good thank you very much and what about the
+
+37
+00:03:03,370 --> 00:03:07,350
+last group yes yes meanpossessive adjective my
+
+38
+00:03:07,350 --> 00:03:13,210
+your her his its in singular and our your their in
+
+39
+00:03:13,210 --> 00:03:17,890
+plural possessive adjective it must followed by
+
+40
+00:03:17,890 --> 00:03:21,490
+the name must be followed by a noun that's right
+
+41
+00:03:21,490 --> 00:03:26,650
+thank you I say my car your house our school and
+
+42
+00:03:26,650 --> 00:03:37,750
+so on okay now if I say I this bookis mine it is
+
+43
+00:03:37,750 --> 00:03:43,570
+about history for example it is a pronoun refers
+
+44
+00:03:43,570 --> 00:03:46,430
+to the book right? what do we call the book?
+
+45
+00:03:49,490 --> 00:03:54,530
+antecedent we call it antecedent so the noun when
+
+46
+00:03:54,530 --> 00:03:58,990
+the pronoun refers to a noun this noun is called
+
+47
+00:03:58,990 --> 00:04:03,110
+antecedent good thank you now we started making
+
+48
+00:04:03,110 --> 00:04:04,290
+exercises right
+
+49
+00:04:22,020 --> 00:04:25,460
+توقفنا على هذا الوضع، و الأن نريد أن نقوم بهذا
+
+50
+00:04:25,460 --> 00:04:31,240
+الوضع نريد
+
+51
+00:04:31,240 --> 00:04:40,240
+أن نقوم بهذا الوضع، قم بقراءة الانتقال، اختيار
+
+52
+00:04:40,240 --> 00:04:42,880
+كلمة صحيحة
+
+53
+00:04:44,610 --> 00:04:51,270
+in italics yeah in italics good go on okay
+
+54
+00:04:51,270 --> 00:04:54,490
+what
+
+55
+00:04:54,490 --> 00:04:58,590
+do you think can you do it this umbrella this pen
+
+56
+00:04:58,590 --> 00:05:08,170
+is mine or is my why my not my okay thank you and
+
+57
+00:05:08,170 --> 00:05:12,990
+the other one the other one is yours come please
+
+58
+00:05:12,990 --> 00:05:13,570
+and do it
+
+59
+00:05:20,030 --> 00:05:28,110
+number two yes please thank
+
+60
+00:05:28,110 --> 00:05:33,490
+you
+
+61
+00:05:33,490 --> 00:05:41,570
+I'm the first one yes go on go on come
+
+62
+00:05:41,570 --> 00:05:44,290
+here please come thank you
+
+63
+00:05:53,190 --> 00:05:57,670
+have their books his okay why you are right but
+
+64
+00:05:57,670 --> 00:06:02,430
+why did you choose these answers okay followed by
+
+65
+00:06:02,430 --> 00:06:12,070
+a noun good okay thank
+
+66
+00:06:12,070 --> 00:06:15,090
+you a pronoun good thank you very much next one
+
+67
+00:06:15,090 --> 00:06:15,950
+yes please come
+
+68
+00:06:27,770 --> 00:06:32,150
+Okay we say what our house or ours house?
+
+69
+00:06:34,930 --> 00:06:39,650
+wait .. wait .. we say this .. this class is ours
+
+70
+00:06:40,480 --> 00:06:45,600
+and this is our class this class is ours or this
+
+71
+00:06:45,600 --> 00:06:49,560
+is our class so what do you think okay our house
+
+72
+00:06:49,560 --> 00:06:56,400
+it is followed by a noun please
+
+73
+00:06:56,400 --> 00:07:07,960
+one speaker give her a chance okay
+
+74
+00:07:09,130 --> 00:07:12,790
+the same as ours or our now what's the difference
+
+75
+00:07:12,790 --> 00:07:20,010
+between our and ours again which one should be
+
+76
+00:07:20,010 --> 00:07:24,870
+followed by a noun now our what do we call our
+
+77
+00:07:24,870 --> 00:07:30,250
+good so it should be followed by a noun and the
+
+78
+00:07:30,250 --> 00:07:34,940
+other one ours is called goodit should it can
+
+79
+00:07:34,940 --> 00:07:38,340
+stand alone yes so now we have a noun we say our
+
+80
+00:07:38,340 --> 00:07:42,200
+house and this is what our neighbor's house we
+
+81
+00:07:42,200 --> 00:07:45,380
+have another noun our so what do you think our
+
+82
+00:07:45,380 --> 00:07:53,640
+good there is
+
+83
+00:07:53,640 --> 00:07:57,540
+no noun good that's right ours is a gray and their
+
+84
+00:07:57,540 --> 00:08:02,120
+or theirs theirs is white thank you
+
+85
+00:08:09,580 --> 00:08:16,460
+next exercise okay read the introduction please
+
+86
+00:08:16,460 --> 00:08:23,460
+okay now what's the difference between the two
+
+87
+00:08:23,460 --> 00:08:28,580
+words what's the difference between them who can
+
+88
+00:08:28,580 --> 00:08:34,850
+say yes pleaseit's apostrophe pronounced and it is
+
+89
+00:08:34,850 --> 00:08:37,510
+.. which one with apostrophe or without apostrophe
+
+90
+00:08:37,510 --> 00:08:42,270
+without apostrophe okay good .. but it is with
+
+91
+00:08:42,270 --> 00:08:49,830
+apostrophe subject now it is again it okay but you
+
+92
+00:08:49,830 --> 00:08:54,210
+are right it is a it refers to the subject now and
+
+93
+00:08:54,210 --> 00:08:57,010
+what about why do we use the apostrophe here
+
+94
+00:08:57,010 --> 00:08:59,070
+because
+
+95
+00:09:03,640 --> 00:09:09,400
+something is something is abbreviated right
+
+96
+00:09:09,400 --> 00:09:15,800
+something is deleted you know it is or it has it
+
+97
+00:09:15,800 --> 00:09:19,900
+is or it has so with apostrophe it is or it has
+
+98
+00:09:19,900 --> 00:09:26,280
+without apostrophe it is used for what okay good
+
+99
+00:09:26,280 --> 00:09:30,920
+to express a possessive good now number one تفضلي
+
+100
+00:09:30,920 --> 00:09:31,340
+come
+
+101
+00:09:38,660 --> 00:09:42,840
+Honeybee has wings on each side of its body.
+
+102
+00:09:45,420 --> 00:09:54,180
+Thank you. Good. Next one. Yes please. Get ready
+
+103
+00:09:54,180 --> 00:09:59,600
+for number four. Yeah. Tom has a bed. It's a ..
+
+104
+00:09:59,600 --> 00:10:03,460
+It's
+
+105
+00:10:03,460 --> 00:10:08,120
+a square. It's a ..Now its name, do we need
+
+106
+00:10:08,120 --> 00:10:13,240
+apostrophe؟ No, we don't need apostrophe, okay
+
+107
+00:10:13,240 --> 00:10:17,220
+good Complete,
+
+108
+00:10:17,340 --> 00:10:23,860
+complete It's been
+
+109
+00:10:23,860 --> 00:10:28,320
+spread for several years Thank you, it has been,
+
+110
+00:10:28,800 --> 00:10:29,960
+good, come please
+
+111
+00:10:37,990 --> 00:10:49,410
+عشان تسألنا مالذي فعلته؟ بلد لا تدفع أطفالها لأنها
+
+112
+00:10:49,410 --> 00:10:54,750
+مستحيلة؟ نعم جيد والنمبر 5 تعالي
+
+113
+00:11:01,650 --> 00:11:04,950
+كلنا نستطيع أن نساعد في إنشاء السلام في العالم،
+
+114
+00:11:04,950 --> 00:11:12,330
+هذا يعني إنه مسؤلنا أن نفعل ذلك، إنه، انت محق، جيد
+
+115
+00:11:12,330 --> 00:11:18,290
+آسف،
+
+116
+00:11:18,290 --> 00:11:23,550
+لم تنتهي، شكرا،
+
+117
+00:11:23,550 --> 00:11:28,150
+أي سؤال عن هذا التعليم؟
+
+118
+00:11:30,640 --> 00:11:33,200
+So you all can distinguish between the two words
+
+119
+00:11:33,200 --> 00:11:38,980
+number four yeah what about it why not it's
+
+120
+00:11:38,980 --> 00:11:44,880
+apostrophe it's children why why so if I use
+
+121
+00:11:44,880 --> 00:11:49,060
+apostrophe it means it is children or it had it's
+
+122
+00:11:49,060 --> 00:11:53,660
+now I want a word to refer to express possessive
+
+123
+00:11:53,660 --> 00:11:59,600
+hereحسنًا أطفالي أطفالك أطفالها أطفالها أطفالها،
+
+124
+00:11:59,600 --> 00:12:00,680
+فهي عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+125
+00:12:00,680 --> 00:12:03,360
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+126
+00:12:03,360 --> 00:12:03,900
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+127
+00:12:03,900 --> 00:12:05,700
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+128
+00:12:05,700 --> 00:12:05,980
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+129
+00:12:05,980 --> 00:12:06,720
+عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة
+
+130
+00:12:06,720 --> 00:12:11,000
+عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن
+
+131
+00:12:16,860 --> 00:12:19,700
+Look at your box and you all do it. You have one
+
+132
+00:12:19,700 --> 00:12:23,580
+minute only. One minute. Do the exercise. All of
+
+133
+00:12:23,580 --> 00:12:25,120
+you. It's a good one
+
+134
+00:12:50,490 --> 00:12:51,530
+بسم الله الرحمن الرحيم
+
+135
+00:13:22,200 --> 00:13:35,060
+Okay, who wants to come here؟ فضلي، come Read
+
+136
+00:13:35,060 --> 00:13:38,180
+aloud and explain to us what you'll do
+
+137
+00:13:54,660 --> 00:13:59,760
+with apostrophe, good, go on it,
+
+138
+00:14:03,120 --> 00:14:11,820
+yeah, it, why it not theyمعنى مفرد؟ مفرد ماذا؟
+
+139
+00:14:11,820 --> 00:14:19,060
+مفرد مفرد مفرد مفرد مفرد مفرد مفرد مفرد مفرد مفرد
+
+140
+00:14:19,060 --> 00:14:19,840
+مفرد مفرد مفرد مفرد مفرد مفرد مفرد مفرد مفرد مفرد
+
+141
+00:14:19,840 --> 00:14:21,340
+مفرد مفرد مفرد مفرد مفرد مفرد مفرد مفرد مفرد مفرد
+
+142
+00:14:21,340 --> 00:14:22,440
+مفرد مفرد مفرد مفرد مفرد مفرد مفرد مفرد مفرد مفرد
+
+143
+00:14:22,440 --> 00:14:25,840
+مفرد مفرد مفرد مفرد مفرد مفرد
+
+144
+00:14:25,840 --> 00:14:31,980
+مفرد مفرد مفرد مفرد
+
+145
+00:14:31,980 --> 00:14:40,810
+مفرد مفرAlso without apostrophe okay on its long
+
+146
+00:14:40,810 --> 00:14:47,550
+pointed bell okay emerging
+
+147
+00:14:47,550 --> 00:14:58,650
+from the water good it tosses thank you catches
+
+148
+00:14:58,650 --> 00:15:00,390
+thank you it
+
+149
+00:15:03,030 --> 00:15:09,830
+and then swallows
+
+150
+00:15:09,830 --> 00:15:21,870
+good yeah it again it's
+
+151
+00:15:21,870 --> 00:15:26,510
+with apostrophe or without it is interesting good
+
+152
+00:15:33,970 --> 00:15:38,050
+أكل؟ الآن نحن نتكلم عن الحيوان و الفيش مع بعض ما
+
+153
+00:15:38,050 --> 00:15:43,770
+رأيك؟ أكلهم او هم؟ جيد جدا شكرا جزيلا شكرا
+
+154
+00:15:56,790 --> 00:16:01,650
+دكتور what about fish? I don't know I'm just
+
+155
+00:16:01,650 --> 00:16:05,410
+confused with sometimes we use it .. you know fish
+
+156
+00:16:05,410 --> 00:16:13,130
+fish okay we can say fish is okay and fish areso
+
+157
+00:16:13,130 --> 00:16:16,670
+in this it depends on the context now he used the
+
+158
+00:16:16,670 --> 00:16:20,410
+article the indefinite article where is it okay a
+
+159
+00:16:20,410 --> 00:16:25,730
+fish eater a fish so a means one give me a buck
+
+160
+00:16:25,730 --> 00:16:31,090
+how many one so this indicates the singular so it
+
+161
+00:16:31,090 --> 00:16:32,050
+is right
+
+162
+00:16:39,200 --> 00:16:43,760
+أشياء أخرى، نعم؟ لماذا إذا؟ لماذا إذا؟ الآن كنا
+
+163
+00:16:43,760 --> 00:16:47,240
+نتحدث عن ماذا؟ الفئران، الفئران، الفئران، الفئران
+
+164
+00:16:47,240 --> 00:16:51,820
+وخيرًا هل تستمتعين بمشاهدة ما؟ الفئران فقط أو
+
+165
+00:16:51,820 --> 00:16:56,820
+الفئران و الفئران؟ الفئران و الفئران، هل تستمتعين
+
+166
+00:16:56,820 --> 00:17:01,540
+بمشاهدة الفئران و الفئران معًا؟ هم في المشهد
+
+167
+00:17:16,340 --> 00:17:24,440
+الان اسمع .. عندما
+
+168
+00:17:24,440 --> 00:17:28,160
+اقول ان
+
+169
+00:17:28,160 --> 00:17:35,620
+طلاق طالق داخل غرفة .. طلاق طالق داخل غرفة .. كان
+
+170
+00:17:35,620 --> 00:17:45,220
+يبحث عن أستاذ .. اين الاسم؟she that's right now
+
+171
+00:17:45,220 --> 00:17:52,020
+does she refer to a particular person or to a
+
+172
+00:17:52,020 --> 00:17:57,520
+general noun particular person okay she must be
+
+173
+00:17:57,520 --> 00:18:03,580
+fatima ghuda khadija and so on right okay now look
+
+174
+00:18:03,580 --> 00:18:06,260
+at the other sentence a student walked into the
+
+175
+00:18:06,260 --> 00:18:13,540
+room he was lookingهو مرة أخرى، هل يشبه كلمة
+
+176
+00:18:13,540 --> 00:18:21,700
+عشوائية أو لشخص محدد؟Okay particular person when I
+
+177
+00:18:21,700 --> 00:18:26,620
+say he must be for example علي أحمد إبراهيم خالد
+
+178
+00:18:26,620 --> 00:18:31,040
+and so on right so we understand that he and she
+
+179
+00:18:31,040 --> 00:18:34,540
+refer always to particular persons they are not
+
+180
+00:18:34,540 --> 00:18:38,980
+generic they are not generic but when I say a
+
+181
+00:18:38,980 --> 00:18:43,700
+student came a student walked a student arrived
+
+182
+00:18:44,310 --> 00:18:47,450
+what do you think a student is it a generic noun
+
+183
+00:18:47,450 --> 00:18:51,010
+or a particular or a definite thing can be any
+
+184
+00:18:51,010 --> 00:18:54,990
+student okay it represents any students can be you
+
+185
+00:18:54,990 --> 00:19:01,930
+can be any student right now nouns like a student
+
+186
+00:19:03,680 --> 00:19:09,960
+والطلاب هم كلمات جينيرية، كلمات جينيرية، ولكن
+
+187
+00:19:09,960 --> 00:19:13,540
+كلمات البرنامج لا يمكن أن تكون كلمات جينيرية هنا،
+
+188
+00:19:13,540 --> 00:19:17,680
+إنهم يتحدثون عن ما يتحدث عنه الطلاب المحدد، حتى
+
+189
+00:19:17,680 --> 00:19:23,040
+وإن كانوا يتحدثون عن كلمات جينيرية، ولكنهم يتحدثون
+
+190
+00:19:23,040 --> 00:19:27,560
+عن الشخص المحدد، هم يتحدثون عن الشخص المحدد،
+
+191
+00:19:31,580 --> 00:19:38,040
+in this sentence a student should always a student
+
+192
+00:19:38,040 --> 00:19:42,160
+when somebody says a student what do you imagine a
+
+193
+00:19:42,160 --> 00:19:45,560
+generic noun right can be any student can be a
+
+194
+00:19:45,560 --> 00:19:49,800
+male or a female right so shall I say a student
+
+195
+00:19:49,800 --> 00:19:54,300
+came into should always do his assignments or her
+
+196
+00:19:54,300 --> 00:19:58,950
+assignmentsلذلك عندما أقول أن طلاب يمكن أن يكون
+
+197
+00:19:58,950 --> 00:20:03,270
+شاب و يمكن أن يكون فتاة، صح؟ نعم. لذلك، من الممكن
+
+198
+00:20:03,270 --> 00:20:07,790
+أن يكون شاب أو فتاة، ماذا أقول؟ أفعل عملياته أو
+
+199
+00:20:07,790 --> 00:20:12,050
+عملياتها؟ عملياته أو عملياتها. لماذا ليس عملياتها؟
+
+200
+00:20:12,050 --> 00:20:15,850
+بعض السيدات ستتصرفون. عملياته أو عملياتها. حسنًا؟
+
+201
+00:20:15,850 --> 00:20:19,430
+الطلاب لا يجب أن يكونوا دائمًا يحكموا. حسنًا،
+
+202
+00:20:19,430 --> 00:20:23,910
+فماذا تفكر، موريدا؟ كلمة طلاب يحاولون أن يكونوا
+
+203
+00:20:23,910 --> 00:20:27,750
+شابين و ليسوا فتاة.and can refer to a female also
+
+204
+00:20:27,750 --> 00:20:33,030
+okay can refer now when I say a student can refer
+
+205
+00:20:33,030 --> 00:20:38,190
+to a male and to a female so how can we solve this
+
+206
+00:20:38,190 --> 00:20:43,550
+problem very good Nada thank you very much we say
+
+207
+00:20:43,550 --> 00:20:48,060
+his or herالكثير من الكتابين بدأوا يقولون كثير،
+
+208
+00:20:48,060 --> 00:20:53,000
+انظروا تقليديًا في كل اللغة الإنقليزية، كانوا
+
+209
+00:20:53,000 --> 00:21:00,600
+يقولون what؟ his، use his for a maleو بعض الكتابين
+
+210
+00:21:00,600 --> 00:21:05,000
+يعتبرونها محكمة الرجل أو محكمة الرجل أو شيء مثل
+
+211
+00:21:05,000 --> 00:21:10,180
+ذلك، لكن الآن أكتر من المجالات، الكثير من الكتابين
+
+212
+00:21:10,180 --> 00:21:15,800
+يقولون هو أو هي، لكي يكونوا صحيحين، لكي لا يفقدوا،
+
+213
+00:21:15,800 --> 00:21:21,500
+نعم، الممكنة الأخرى، حتى
+
+214
+00:21:21,500 --> 00:21:25,400
+في العربية أحيانا، حتى في العربية أحيانا نستخدم
+
+215
+00:21:26,430 --> 00:21:31,410
+Okay, both of them, right؟ أكتب, right؟ And
+
+216
+00:21:31,410 --> 00:21:35,730
+sometimes in the exam أكتب، أكتبي, right؟ We use
+
+217
+00:21:35,730 --> 00:21:40,290
+it even in Arabic Some people consider the
+
+218
+00:21:40,290 --> 00:21:44,170
+masculine is enough, okay, his And others, no,
+
+219
+00:21:44,410 --> 00:21:47,650
+they should refer or they should point to the
+
+220
+00:21:47,650 --> 00:21:53,730
+femininegender hair so now how can we solve this
+
+221
+00:21:53,730 --> 00:21:57,430
+problem you see you see as you see a student
+
+222
+00:21:57,430 --> 00:22:03,090
+should do his why not hair so write his or her how
+
+223
+00:22:03,090 --> 00:22:07,530
+can we solve this problem this is a problem what
+
+224
+00:22:07,530 --> 00:22:13,630
+do you think in writing yes say
+
+225
+00:22:13,630 --> 00:22:19,190
+it speak aloud change it to another pronounanother
+
+226
+00:22:19,190 --> 00:22:23,450
+pronoun like what another pronoun which may
+
+227
+00:22:23,450 --> 00:22:27,670
+include he and she right very good what's that
+
+228
+00:22:27,670 --> 00:22:34,030
+pronoun his or her can change to their very good
+
+229
+00:22:34,030 --> 00:22:37,450
+thank you very much thank you in other words we
+
+230
+00:22:37,450 --> 00:22:41,220
+make it whatplural نعم نعم نعم نعم نعم نعم نعم نعم
+
+231
+00:22:41,220 --> 00:22:43,540
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+232
+00:22:43,540 --> 00:22:43,940
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+233
+00:22:43,940 --> 00:22:44,520
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+234
+00:22:44,520 --> 00:22:46,120
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+235
+00:22:46,120 --> 00:22:48,680
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+236
+00:22:48,680 --> 00:22:49,860
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+237
+00:22:49,860 --> 00:22:52,080
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+238
+00:22:52,080 --> 00:22:56,260
+نعم نعم نعم نعم نعم نعم
+
+239
+00:22:56,260 --> 00:22:57,220
+نعم
+
+240
+00:23:07,600 --> 00:23:11,560
+Okay look before we talk about them they are what
+
+241
+00:23:11,560 --> 00:23:16,720
+how many words one word so everyone is what one
+
+242
+00:23:16,720 --> 00:23:21,180
+word everybody everything okay read the other
+
+243
+00:23:21,180 --> 00:23:28,020
+group please thank you the other ones thank you
+
+244
+00:23:28,020 --> 00:23:34,340
+and the other ones good so remember they should be
+
+245
+00:23:34,340 --> 00:23:37,120
+what one word now
+
+246
+00:23:38,900 --> 00:23:48,480
+somebody .. somebody refers to what؟ sorry؟ okay
+
+247
+00:23:48,480 --> 00:23:53,960
+somebody left his book on the desksomebody left
+
+248
+00:23:53,960 --> 00:23:58,720
+his okay somebody left his his refers to a
+
+249
+00:23:58,720 --> 00:24:03,600
+singular person right a singular noun everyone has
+
+250
+00:24:03,600 --> 00:24:09,700
+his or her okay has his or her again can be a male
+
+251
+00:24:09,700 --> 00:24:15,940
+or can be a female can refer to one of them now in
+
+252
+00:24:15,940 --> 00:24:22,120
+old English most of the books used to write hisIn
+
+253
+00:24:22,120 --> 00:24:25,940
+other words to consider it singular and in spoken
+
+254
+00:24:25,940 --> 00:24:31,960
+English when you are talkingagain in formal
+
+255
+00:24:31,960 --> 00:24:36,600
+English it is used it is considered what his so
+
+256
+00:24:36,600 --> 00:24:41,280
+his this is one somebody left his in formal
+
+257
+00:24:41,280 --> 00:24:44,420
+English the use of a singular pronoun to refer to
+
+258
+00:24:44,420 --> 00:24:47,740
+an indefinite pronoun is generally considered to
+
+259
+00:24:47,740 --> 00:24:51,120
+be grammatically correct so this is accepted in
+
+260
+00:24:51,120 --> 00:24:55,380
+formal English I say somebody left his somebody
+
+261
+00:24:56,100 --> 00:24:59,940
+Lift her, everyone should bring her and so on,
+
+262
+00:25:00,020 --> 00:25:04,040
+should bring his, this is وقت, this is formal Now
+
+263
+00:25:04,040 --> 00:25:07,860
+what about the everyday English, when people speak
+
+264
+00:25:07,860 --> 00:25:12,280
+to each other, they say somebody lift them, okay
+
+265
+00:25:12,280 --> 00:25:18,600
+everyone has their own ideas Now which one shall I
+
+266
+00:25:18,600 --> 00:25:22,240
+use?between friends in everyday language most
+
+267
+00:25:22,240 --> 00:25:26,420
+people use what used there use the plural form but
+
+268
+00:25:26,420 --> 00:25:32,580
+in formal writing and sometimes okay in the very
+
+269
+00:25:32,580 --> 00:25:36,680
+formal they use what they use there but commonly
+
+270
+00:25:36,680 --> 00:25:41,380
+we can say that this is the formal formhis or her
+
+271
+00:25:41,380 --> 00:25:46,020
+and this is the informal used in everyday life
+
+272
+00:25:46,020 --> 00:25:50,240
+between friends in spoken English and so on is
+
+273
+00:25:50,240 --> 00:25:56,820
+that okay now let's have an exercise yeah
+
+274
+00:25:56,820 --> 00:25:59,980
+read please the introduction read it from your
+
+275
+00:25:59,980 --> 00:26:00,300
+book
+
+276
+00:26:03,250 --> 00:26:05,850
+it's in the sentences by using plural instead of
+
+277
+00:26:05,850 --> 00:26:08,370
+singular generic nouns where possible, change
+
+278
+00:26:08,370 --> 00:26:10,730
+pronouns and verbs as necessary to sculpt the
+
+279
+00:26:10,730 --> 00:26:14,190
+advantages of using plural rather than singular
+
+280
+00:26:14,190 --> 00:26:23,130
+generic nouns okay now let's do number one when
+
+281
+00:26:23,130 --> 00:26:27,730
+I say each student in biology 101 has to
+
+282
+00:26:33,800 --> 00:26:42,400
+كل طلاب يجب
+
+283
+00:26:42,400 --> 00:26:48,200
+أن يقضي ثلاث ساعات في البيولوجيا 101 في البرتريو
+
+284
+00:26:52,880 --> 00:26:58,760
+by following the directions in yes or love manual
+
+285
+00:26:58,760 --> 00:27:05,400
+okay now all students yeah we write what come you
+
+286
+00:27:05,400 --> 00:27:11,880
+are right all students so instead of each student
+
+287
+00:27:11,880 --> 00:27:18,680
+is we say what all students are okay all students
+
+288
+00:27:23,220 --> 00:27:30,160
+students yeah good complete has to students has to
+
+289
+00:27:30,160 --> 00:27:37,200
+or have to have to good spend three hours per week
+
+290
+00:27:37,200 --> 00:27:40,560
+yeah
+
+291
+00:27:40,560 --> 00:27:46,200
+what do you think of he or she they very good yeah
+
+292
+00:27:46,200 --> 00:27:49,780
+they they
+
+293
+00:27:49,780 --> 00:27:56,750
+does dothey they do thank you very much any other
+
+294
+00:27:56,750 --> 00:28:09,030
+changes in his or her okay thank you and they're
+
+295
+00:28:09,030 --> 00:28:16,010
+they're spelling ei ei okay yeah you want to do it
+
+296
+00:28:16,010 --> 00:28:17,550
+okay come okay
+
+297
+00:28:21,320 --> 00:28:31,820
+get ready for the other one citizens
+
+298
+00:28:31,820 --> 00:28:36,460
+have
+
+299
+00:28:43,460 --> 00:28:46,000
+بقى دقيقة دقيقة دقيقة دقيقة دقيقة دقيقة دقيقة
+
+300
+00:28:46,000 --> 00:29:07,300
+دقيقة دقيقة دقيقة دقيقة دقيقة
+
+301
+00:29:07,810 --> 00:29:10,490
+باستخدام كلمة عشان كلمة عشان كلمة عشان كلمة عشان
+
+302
+00:29:10,490 --> 00:29:14,490
+كلمة عشان كلمة عشان كلمة عشان كلمة عشان كلمة عشان
+
+303
+00:29:14,490 --> 00:29:14,870
+كلمة عشان كلمة عشان كلمة عشان كلمة عشان كلمة عشان
+
+304
+00:29:14,870 --> 00:29:18,130
+كلمة عشان كلمة عشان كلمة عشان كلمة عشان كلمة عشان
+
+305
+00:29:18,130 --> 00:29:18,370
+كلمة عشان كلمة عشان كلمة عشان كلمة عشان كلمة عشان
+
+306
+00:29:18,370 --> 00:29:18,390
+كلمة عشان كلمة عشان كلمة عشان كلمة عشان كلمة عشان
+
+307
+00:29:18,390 --> 00:29:20,650
+كلمة عشان كلمة عشان كلمة عشان كلمة عشان كلمة عشان
+
+308
+00:29:20,650 --> 00:29:27,290
+كلمة
+
+309
+00:29:27,290 --> 00:29:33,790
+عشان كلمة عشان
+
+310
+00:29:33,790 --> 00:29:36,290
+كلم
+
+311
+00:29:37,220 --> 00:29:44,060
+ماذا يعني جالب؟ اتفقده في الكتابة ايه؟
+
+312
+00:29:44,060 --> 00:29:50,140
+من كان يسأل هناك؟ فضلي فقط لحظة، لديها سؤال نمبر
+
+313
+00:29:50,140 --> 00:29:55,420
+ثلاثة نمبر ثلاثة، ماذا عن نمبر ثلاثة؟ نعم، الأخير؟
+
+314
+00:29:55,420 --> 00:29:59,320
+لهم؟
+
+315
+00:29:59,320 --> 00:30:08,630
+حسنا، لماذا لهم؟ لماذا لهم؟لأ if this is a noun if
+
+316
+00:30:08,630 --> 00:30:14,570
+I have them this is for them this is for you right
+
+317
+00:30:14,570 --> 00:30:22,050
+it should not be followed by a noun it should not
+
+318
+00:30:22,050 --> 00:30:26,010
+be followed by a noun so we say there but you know
+
+319
+00:30:26,010 --> 00:30:29,070
+there look at the spelling
+
+320
+00:30:36,440 --> 00:30:44,020
+أشياء أخرى؟ ماذا عن نفس التجارب، رقم 2 رقم 2؟ ليس
+
+321
+00:30:44,020 --> 00:30:48,500
+مغلقا، ليس هنا رقم 2 في الكتاب تقصد؟ نعم، نعم ليس
+
+322
+00:30:48,500 --> 00:30:53,580
+مغلقا، لماذا؟ لأنها ربما .. لماذا؟ ليس مغلقا؟ نعم
+
+323
+00:30:53,580 --> 00:31:00,340
+قولها أرجوك أتحدثت لدراسة في دراسة دراستي وطلبت نص
+
+324
+00:31:00,340 --> 00:31:04,650
+من الدراسة التي أقابلتها، وقد أعطيته لدي بسرعةوهذا
+
+325
+00:31:04,650 --> 00:31:11,390
+كلمة جيدة، لماذا نتغيرها؟ انها كلمة جيدة، انظر الى
+
+326
+00:31:11,390 --> 00:31:17,830
+رقم 5 انظر الى رقم 5، من سيقوم بالتغيير؟ انها لك،
+
+327
+00:31:17,830 --> 00:31:21,630
+فماذا عن التغييرات؟ أين هي التغييرات؟ انها جيدة
+
+328
+00:31:21,630 --> 00:31:26,030
+أنك ستجعلها؟
+
+329
+00:31:26,030 --> 00:31:28,030
+لا، ليس هناك مشكلة
+
+330
+00:31:39,150 --> 00:31:48,630
+لا تغير، أنت محق، شكرا، محق، لا تغير لا بأس، اكتر،
+
+331
+00:31:48,630 --> 00:31:50,930
+اكتر، اكتر، اكتر، اكتر، اكتر، اكتر، اكتر، اكتر،
+
+332
+00:31:50,930 --> 00:31:53,810
+اكتر، اكتر، اكتر، اكتر، اكتر، اكتر، اكتر، اكتر،
+
+333
+00:31:53,810 --> 00:31:53,970
+اكتر، اكتر، اكتر، اكتر، اكتر، اكتر، اكتر، اكتر،
+
+334
+00:31:53,970 --> 00:31:55,850
+اكتر، اكتر، اكتر، اكتر، اكتر، اكتر، اكتر، اكتر،
+
+335
+00:31:55,850 --> 00:32:00,530
+اكتر، اكتر، اكتر، اكتر، اكتر، اكتر، ا
+
+336
+00:32:11,540 --> 00:32:25,460
+الان هذا مرحلة أخرى ماذا
+
+337
+00:32:25,460 --> 00:32:32,010
+يريد؟ قم بقراءة الانتقال في كتابكComplete each
+
+338
+00:32:32,010 --> 00:32:35,450
+sentence with the pronouns that seems appropriate
+
+339
+00:32:35,450 --> 00:32:38,330
+to the given situation. Choose the correct verbs
+
+340
+00:32:38,330 --> 00:32:44,230
+and parties as Nisari discuss formal and informal
+
+341
+00:32:44,230 --> 00:32:48,310
+pronouns Okay thank you. Now the first one number
+
+342
+00:32:48,310 --> 00:32:54,660
+two. Who wants to start? Go on. Yasminone friend
+
+343
+00:32:54,660 --> 00:32:57,160
+to another of course you can learn to dance just a
+
+344
+00:32:57,160 --> 00:33:00,400
+minute please one friend to another what does that
+
+345
+00:33:00,400 --> 00:33:04,100
+mean is it a formal situation it is informal
+
+346
+00:33:04,100 --> 00:33:09,160
+situation good this is informal situation go on of
+
+347
+00:33:09,160 --> 00:33:12,120
+course you can learn to dance anyone can learn how
+
+348
+00:33:12,120 --> 00:33:17,040
+to dance if you want toإذا كنا نريد أن نستخدم كلمة
+
+349
+00:33:17,040 --> 00:33:22,400
+واحدة يمكننا أن نتعرف عليها أي شخص نريد كلمة واحدة
+
+350
+00:33:22,400 --> 00:33:25,480
+نتعرف عليها أي شخص كلمة واحدة الـ Indefinite
+
+351
+00:33:25,480 --> 00:33:31,160
+pronoun هم جيد جدًا هم لأن هذا كما قلنا في حالة
+
+352
+00:33:31,160 --> 00:33:36,440
+عامة جيدة إذا كنا
+
+353
+00:33:36,440 --> 00:33:37,300
+نستطيع أن نتعرف عليها كلمة واحدة يمكننا أن نتعرف
+
+354
+00:33:37,300 --> 00:33:41,040
+عليها كلمة واحدة كلمة واحدة
+
+355
+00:33:42,160 --> 00:33:47,100
+Okay, clean this. And which
+
+356
+00:33:47,100 --> 00:33:52,040
+verb do we use؟ Okay,
+
+357
+00:33:52,160 --> 00:33:57,120
+thank you very much. Good. Next one, come. You
+
+358
+00:33:57,120 --> 00:34:02,840
+want to ask؟ Now we said .. now she is asking
+
+359
+00:34:02,840 --> 00:34:06,760
+anyone. Do we use a singular pronoun or a plural
+
+360
+00:34:06,760 --> 00:34:10,120
+pronoun to refer to anyone? Who can answer her
+
+361
+00:34:10,120 --> 00:34:17,000
+question?we say that in formal language we use
+
+362
+00:34:17,000 --> 00:34:21,780
+there or plural as plural but in formal writing we
+
+363
+00:34:21,780 --> 00:34:28,820
+use he or she or he or she okay now sorry again
+
+364
+00:34:28,820 --> 00:34:37,570
+anyone prefer toكما قلنا أننا يجب أن نعتبر اذا كنت
+
+365
+00:34:37,570 --> 00:34:44,210
+تتعامل مع حالة عامة او حالة غير عامة في حالة عامة
+
+366
+00:34:44,210 --> 00:34:55,950
+نقول it وفي حالة غير عامة نقول they لماذا
+
+367
+00:34:55,950 --> 00:34:59,810
+قام بالتعريف بهذه التعريف؟ من صديق إلى صديق آخر
+
+368
+00:35:00,780 --> 00:35:06,680
+الكتير يريد أن يخبرك أن هذه حالة غير عامة، حسنا؟
+
+369
+00:35:06,680 --> 00:35:12,020
+هذه حالة غير عامة، نعم، لماذا قلت؟ تعالي، نحن
+
+370
+00:35:12,020 --> 00:35:15,680
+ننتظر، نعم،
+
+371
+00:35:15,680 --> 00:35:20,480
+الأعمال تأخذ المساعدة،
+
+372
+00:35:20,480 --> 00:35:25,960
+هذا ما ..؟ أعمال ، جيد، تابعين ، المدير المساعد
+
+373
+00:35:25,960 --> 00:35:31,460
+يجب أن يكون قادر على تحفيز المستخدمينI don't know
+
+374
+00:35:31,460 --> 00:35:34,660
+this is for you why there
+
+375
+00:35:37,710 --> 00:35:40,310
+Now we said look at the previous one, number two
+
+376
+00:35:40,310 --> 00:35:44,270
+this is informal situation In the informal we use
+
+377
+00:35:44,270 --> 00:35:48,350
+the plural they, right? And now this is informal
+
+378
+00:35:48,350 --> 00:35:52,930
+and this is formal So in the formal .. okay now
+
+379
+00:35:52,930 --> 00:35:57,670
+listen, the manager can be a male and .. or a
+
+380
+00:35:57,670 --> 00:36:02,090
+female So what shall I write? His or her, very
+
+381
+00:36:02,090 --> 00:36:02,910
+good, thank you
+
+382
+00:36:07,000 --> 00:36:12,080
+ممكن تكتب صفته فقط ممكن تكتب صفته فقط .. ممكن تكتب
+
+383
+00:36:12,080 --> 00:36:13,960
+صفته فقط .. ممكن تكتب صفته فقط .. ممكن تكتب صفته
+
+384
+00:36:13,960 --> 00:36:14,340
+فقط .. ممكن تكتب صفته فقط .. ممكن تكتب صفته فقط ..
+
+385
+00:36:14,340 --> 00:36:14,500
+صفته فقط .. ممكن تكتب صفته فقط .. ممكن تكتب صفته
+
+386
+00:36:14,500 --> 00:36:15,200
+فقط .. ممكن تكتب صفته فقط .. ممكن تكتب صفته فقط ..
+
+387
+00:36:15,200 --> 00:36:25,720
+ممكن تكتب صفته فقط .. ممكن تكتب صفته فقط .. ممكن
+
+388
+00:36:25,720 --> 00:36:30,580
+تكتب صفتهthis is informal very good this is
+
+389
+00:36:30,580 --> 00:36:33,260
+informal look this introduction is very important
+
+390
+00:36:33,260 --> 00:36:38,640
+yeah go on very
+
+391
+00:36:38,640 --> 00:36:42,460
+good
+
+392
+00:36:42,460 --> 00:36:50,960
+tell them number
+
+393
+00:36:50,960 --> 00:36:55,500
+five new ones come please then you get ready okay
+
+394
+00:37:03,060 --> 00:37:06,140
+Okay, son to his mother, what does that indicate?
+
+395
+00:37:06,300 --> 00:37:09,860
+Formal or informal? Informal situation. Good, go
+
+396
+00:37:09,860 --> 00:37:17,300
+on. Their own food. Okay, clean the previous ones
+
+397
+00:37:17,300 --> 00:37:19,280
+please. Clean them.
+
+398
+00:37:23,120 --> 00:37:29,480
+Their own food, yeah. Thank you. Yes, come please.
+
+399
+00:37:41,570 --> 00:37:45,890
+ه university lecture it is a formal situation go
+
+400
+00:37:45,890 --> 00:37:54,710
+on very
+
+401
+00:37:54,710 --> 00:38:04,670
+good with his or her thank you yeah come thank
+
+402
+00:38:04,670 --> 00:38:04,910
+you
+
+403
+00:38:08,500 --> 00:38:12,500
+ماذا يظهر في مجلس الفيديو؟ فورمال مرة أخرى، اذهب
+
+404
+00:38:12,500 --> 00:38:30,600
+شكرا
+
+405
+00:38:30,600 --> 00:38:38,600
+شكرا، يمكنك أيضًا كتابةhis okay or instead of the
+
+406
+00:38:38,600 --> 00:38:47,080
+slash his or her check
+
+407
+00:38:47,080 --> 00:38:56,940
+your answers now
+
+408
+00:38:56,940 --> 00:39:01,800
+let's stop at this point and
+
+409
+00:39:01,800 --> 00:39:03,020
+say goodbye for today
+
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/31n8CPEpBQY_raw.srt b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/31n8CPEpBQY_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..93a08d943ecbbe2345d7c8387c1af6cf81febba5
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/31n8CPEpBQY_raw.srt
@@ -0,0 +1,1884 @@
+1
+00:00:20,970 --> 00:00:26,650
+Good morning to you all how are you? I'm nice
+
+2
+00:00:26,650 --> 00:00:30,830
+thank you very much feeling well today? fine good
+
+3
+00:00:30,830 --> 00:00:34,470
+so let's start with a smile it is a nice day today
+
+4
+00:00:34,470 --> 00:00:42,870
+a nice weather okay you know مروة has a story مروة
+
+5
+00:00:42,870 --> 00:00:46,770
+usually comes by bus to the university you know
+
+6
+00:00:46,770 --> 00:00:49,730
+what happened today? no
+
+7
+00:00:59,770 --> 00:01:09,210
+when she arrived at
+
+8
+00:01:09,210 --> 00:01:19,230
+the station the bus station the bus had
+
+9
+00:01:19,230 --> 00:01:29,390
+left when she arrived the bus had leftDid she come
+
+10
+00:01:29,390 --> 00:01:35,610
+by bus? No. Did she catch the bus? No. What does
+
+11
+00:01:35,610 --> 00:01:40,570
+that mean? What does that mean? Look, she arrived
+
+12
+00:01:40,570 --> 00:01:46,850
+and had left. I used two tenses. The two tenses
+
+13
+00:01:46,850 --> 00:01:51,130
+happened in the past. Good. Which happened before?
+
+14
+00:01:51,730 --> 00:01:58,750
+Yes please.very good the bus left then she arrived
+
+15
+00:01:58,750 --> 00:02:04,450
+now we use two tenses which tense is this? this
+
+16
+00:02:04,450 --> 00:02:09,110
+the past simple good and this one okay good so can
+
+17
+00:02:09,110 --> 00:02:13,630
+you tell me why or when do we use the past
+
+18
+00:02:13,630 --> 00:02:18,220
+perfect?yes ياسمين when we have two actions
+
+19
+00:02:18,220 --> 00:02:22,480
+someone happens before another very good someone
+
+20
+00:02:22,480 --> 00:02:27,180
+completed okay finished started and completed
+
+21
+00:02:27,180 --> 00:02:31,460
+before another action or before another time this
+
+22
+00:02:31,460 --> 00:02:32,180
+is nice good
+
+23
+00:02:48,040 --> 00:02:55,380
+now look read the example please yeah yes read it
+
+24
+00:02:55,380 --> 00:03:01,240
+thank
+
+25
+00:03:01,240 --> 00:03:08,360
+you look at the time left at nine thirty arrived
+
+26
+00:03:08,360 --> 00:03:12,680
+at ten which happened beforewhich happened .. one
+
+27
+00:03:12,680 --> 00:03:16,620
+speaker please one speaker yes please okay thank
+
+28
+00:03:16,620 --> 00:03:21,280
+you left علي left before Sammy arrived the two
+
+29
+00:03:21,280 --> 00:03:24,500
+actions happened in the past but according to the
+
+30
+00:03:24,500 --> 00:03:29,720
+time given we know that this happened first so if
+
+31
+00:03:29,720 --> 00:03:34,760
+we want to talk about or to use two tenses to
+
+32
+00:03:34,760 --> 00:03:39,840
+express the situation we say yes ولا what do we
+
+33
+00:03:39,840 --> 00:03:40,940
+say علي
+
+34
+00:03:43,540 --> 00:03:47,440
+very good علي had already left when Sammy arrived
+
+35
+00:03:47,440 --> 00:03:53,240
+it means what first علي left second Sammy arrived
+
+36
+00:03:53,240 --> 00:04:02,200
+thank you read please نيفين thank
+
+37
+00:04:02,200 --> 00:04:05,680
+you
+
+38
+00:04:05,680 --> 00:04:10,820
+very much good yeah what do you understand نور can
+
+39
+00:04:10,820 --> 00:04:12,540
+you summarize yeah
+
+40
+00:04:20,100 --> 00:04:23,900
+very good thank you very much happened completed
+
+41
+00:04:23,900 --> 00:04:28,700
+before the other tense thank you now read the
+
+42
+00:04:28,700 --> 00:04:34,660
+other sentence بسمة okay
+
+43
+00:04:34,660 --> 00:04:40,040
+thank you very much Sami got Ali had already left
+
+44
+00:04:40,040 --> 00:04:46,030
+did they meetDid Sami see Ali? Did Sami see Ali?
+
+45
+00:04:46,290 --> 00:04:54,330
+اه مريضة Thank you So he did not see Ali Why? How
+
+46
+00:04:54,330 --> 00:04:59,350
+did you know? So how? Had already left Thank you
+
+47
+00:04:59,350 --> 00:05:04,690
+very much Now already When I say Ali had left Does
+
+48
+00:05:04,690 --> 00:05:07,890
+it give you a good meaning? A good grammar? Yes
+
+49
+00:05:07,890 --> 00:05:12,910
+When I use alreadyalready to emphasize the meaning
+
+50
+00:05:12,910 --> 00:05:18,470
+very good so we use some adverbs some reference to
+
+51
+00:05:18,470 --> 00:05:22,330
+the time some words that refer to the some words
+
+52
+00:05:22,330 --> 00:05:26,090
+to emphasize the action the action has already we
+
+53
+00:05:26,090 --> 00:05:29,990
+say already when i say also by the time this is
+
+54
+00:05:29,990 --> 00:05:33,550
+another time expression used okay another
+
+55
+00:05:33,550 --> 00:05:38,400
+expression used with the past perfectNow read
+
+56
+00:05:38,400 --> 00:05:44,720
+Sahar the first sentence please she .. she wants
+
+57
+00:05:44,720 --> 00:05:52,860
+to visit okay good she wants to visit she has seen
+
+58
+00:05:52,860 --> 00:05:58,460
+what is the tense here present simple and this one
+
+59
+00:05:58,460 --> 00:06:03,040
+present perfect good which happened first the
+
+60
+00:06:03,040 --> 00:06:08,110
+simple or the perfect yes please very goodOkay the
+
+61
+00:06:08,110 --> 00:06:12,730
+perfect so again because she has seen she once
+
+62
+00:06:12,730 --> 00:06:18,210
+okay now read the other example please آية read
+
+63
+00:06:18,210 --> 00:06:25,070
+this one she good
+
+64
+00:06:25,070 --> 00:06:29,970
+she wanted to visit because she had seen again the
+
+65
+00:06:29,970 --> 00:06:36,890
+simple past and the okay which happened firstthe
+
+66
+00:06:36,890 --> 00:06:41,970
+perfect very good now look prison simple prison
+
+67
+00:06:41,970 --> 00:06:47,390
+perfect past simple past perfect the prison simple
+
+68
+00:06:47,390 --> 00:06:52,410
+happen .. happens before the the prison perfect
+
+69
+00:06:52,410 --> 00:06:56,050
+happens before the prison simple and the past
+
+70
+00:06:56,050 --> 00:07:03,420
+perfect okay so the perfectOkay, happens before
+
+71
+00:07:03,420 --> 00:07:08,080
+the symbol. The relationship between the present
+
+72
+00:07:08,080 --> 00:07:12,560
+simple and the present perfect is similar to that
+
+73
+00:07:12,560 --> 00:07:16,280
+between the past simple and the past perfect. In
+
+74
+00:07:16,280 --> 00:07:19,600
+other words, the perfect happens before what?
+
+75
+00:07:20,220 --> 00:07:24,860
+Before the simple. Good.and read Najwa this one
+
+76
+00:07:24,860 --> 00:07:36,280
+okay
+
+77
+00:07:36,280 --> 00:07:41,460
+thank
+
+78
+00:07:41,460 --> 00:07:45,480
+you very much again when we use the symbol with
+
+79
+00:07:45,480 --> 00:07:52,360
+the perfect okay the perfect happens beforeOkay
+
+80
+00:07:52,360 --> 00:07:57,260
+thank you very much, that's nice, good Could you
+
+81
+00:07:57,260 --> 00:08:02,460
+read this example please, yeah? She had met as a
+
+82
+00:08:02,460 --> 00:08:07,940
+manager of many companieson many occasions this is
+
+83
+00:08:07,940 --> 00:08:11,860
+enough thank you good she had met the manager on
+
+84
+00:08:11,860 --> 00:08:16,060
+many occasions she was a reporter for example she
+
+85
+00:08:16,060 --> 00:08:19,700
+wanted to make a research and she visited the
+
+86
+00:08:19,700 --> 00:08:23,000
+manager and then visited the manager and repeated
+
+87
+00:08:23,000 --> 00:08:26,760
+the action and repeated the action the manager
+
+88
+00:08:26,760 --> 00:08:31,920
+offered her a job okay the manager offered her a
+
+89
+00:08:31,920 --> 00:08:38,960
+job nowshe had met the manager on many occasions
+
+90
+00:08:38,960 --> 00:08:45,820
+before she got the job I have two actions okay the
+
+91
+00:08:45,820 --> 00:08:50,780
+first action was okay it is past perfect but you
+
+92
+00:08:50,780 --> 00:08:55,180
+know it was repeated that's right thank you it was
+
+93
+00:08:55,180 --> 00:08:59,100
+repeated happened again and again and again then
+
+94
+00:08:59,100 --> 00:09:02,960
+another action happened okay complete please read
+
+95
+00:09:09,540 --> 00:09:15,560
+Thank you very much I had visited the area before
+
+96
+00:09:15,560 --> 00:09:20,700
+I bought the house I had visited the area before I
+
+97
+00:09:20,700 --> 00:09:24,600
+bought the house I wanted to live in a new area so
+
+98
+00:09:24,600 --> 00:09:31,800
+I visited it a lot of times okay then I bought Can
+
+99
+00:09:31,800 --> 00:09:37,070
+you give me examples about yourself?Examples about
+
+100
+00:09:37,070 --> 00:09:42,530
+yourself Now
+
+101
+00:09:42,530 --> 00:09:49,350
+Suha has a new bag You know what did .. what did
+
+102
+00:09:49,350 --> 00:09:54,650
+she do? She had visited many shops before she
+
+103
+00:09:54,650 --> 00:10:00,530
+bought the bagOkay she had visited, so again the
+
+104
+00:10:00,530 --> 00:10:04,550
+action was repeated before another action happened
+
+105
+00:10:04,550 --> 00:10:18,470
+or started Yes فضلي Very good I had goneOkay she
+
+106
+00:10:18,470 --> 00:10:21,890
+came and came and came then she started thank you
+
+107
+00:10:21,890 --> 00:10:28,610
+yes please yes me thank you very much good now
+
+108
+00:10:28,610 --> 00:10:35,530
+read the other example please read thank you very
+
+109
+00:10:35,530 --> 00:10:42,030
+much look had left and left had left and left okay
+
+110
+00:10:42,030 --> 00:10:47,890
+nowthis is what? past perfect and this is what?
+
+111
+00:10:47,990 --> 00:10:53,910
+past simple look when we talk about the time
+
+112
+00:10:53,910 --> 00:10:57,610
+relation between some verbs if I say for example
+
+113
+00:10:57,610 --> 00:11:06,600
+eat and watch TVwhich usually happens first? you
+
+114
+00:11:06,600 --> 00:11:09,020
+want to eat and you want to watch TV?
+
+115
+00:11:13,020 --> 00:11:18,600
+no I'm asking you usually is there .. which
+
+116
+00:11:18,600 --> 00:11:21,980
+happens first? in other words is there a clear
+
+117
+00:11:21,980 --> 00:11:25,060
+time relationship between the two verbs? no
+
+118
+00:11:26,490 --> 00:11:30,290
+Sometimes I want to eat. I eat because it's not
+
+119
+00:11:30,290 --> 00:11:33,710
+time for my favorite program. I have some minutes
+
+120
+00:11:33,710 --> 00:11:36,650
+to eat, right؟
+
+121
+00:11:38,320 --> 00:11:43,960
+البرنامج قد بدأ بالفعل لذا انا اشاهد البرنامج
+
+122
+00:11:43,960 --> 00:11:48,580
+اشاهد التلفاز ثم انا انام صح؟ اذا انا اريد ان اجعل
+
+123
+00:11:48,580 --> 00:11:53,740
+علاقات الوقت بين الاثنين الأفعال واضحة في كلمات
+
+124
+00:11:53,740 --> 00:11:57,760
+أخرى اذا اريد ان اخبر المقرر أي أفعال حدثت أولا
+
+125
+00:11:57,760 --> 00:12:04,140
+استخدمت ماذا؟ قبل و بعد قبل و بعد جيد جدا استطيع
+
+126
+00:12:04,140 --> 00:12:14,150
+استخدام قبل أو بعد اوOkay before after or we use
+
+127
+00:12:14,150 --> 00:12:20,330
+what the past perfect okay we use the past perfect
+
+128
+00:12:20,330 --> 00:12:23,870
+so we use the past perfect to show the time
+
+129
+00:12:23,870 --> 00:12:27,150
+relationship between the two actions or we use
+
+130
+00:12:27,150 --> 00:12:34,950
+what before or after now when I say before I
+
+131
+00:12:37,130 --> 00:12:47,570
+it .. I watched TV now according to the sentence
+
+132
+00:12:47,570 --> 00:12:52,870
+in this sentence is the time relationship between
+
+133
+00:12:52,870 --> 00:12:58,690
+the two verbs clear? which happened first?which
+
+134
+00:12:58,690 --> 00:13:03,690
+happened first watch it so it means before I ate I
+
+135
+00:13:03,690 --> 00:13:07,090
+watch it this happened this then this happened
+
+136
+00:13:07,090 --> 00:13:13,110
+okay now can I say after who's
+
+137
+00:13:13,110 --> 00:13:19,630
+the speaker after after I want the same the same
+
+138
+00:13:19,630 --> 00:13:22,090
+meaning I don't want to change the meaning you can
+
+139
+00:13:22,090 --> 00:13:25,410
+say after I ate I watch it but I want the same
+
+140
+00:13:25,410 --> 00:13:36,940
+meaning after yes go onفضليه after I watched TV I
+
+141
+00:13:36,940 --> 00:13:43,960
+ate after I watched I ate is the time relationship
+
+142
+00:13:43,960 --> 00:13:47,040
+between the two verbs the simple past and the
+
+143
+00:13:47,040 --> 00:13:51,320
+simple past clear yes is it clear can you say
+
+144
+00:13:51,320 --> 00:13:55,900
+which one happened first yesSo is it necessary to
+
+145
+00:13:55,900 --> 00:14:00,860
+use the past perfect in this sentence? No, it is
+
+146
+00:14:00,860 --> 00:14:04,320
+not necessary. We use the past perfect to show
+
+147
+00:14:04,320 --> 00:14:07,800
+which action happened first. But if the time
+
+148
+00:14:07,800 --> 00:14:11,520
+relationship between the two actions is clear, use
+
+149
+00:14:11,520 --> 00:14:14,760
+the symbol and the symbol. We don't need it. So it
+
+150
+00:14:14,760 --> 00:14:19,490
+is not necessary to use what? The past perfect.but
+
+151
+00:14:19,490 --> 00:14:23,290
+it is not commonly not recommended okay we said it
+
+152
+00:14:23,290 --> 00:14:39,890
+is unnecessary .. unnecessary right؟
+
+153
+00:14:39,890 --> 00:14:45,570
+yes read the sentence again لما okay
+
+154
+00:14:48,420 --> 00:14:53,940
+the two sentences have the same meaning so again
+
+155
+00:14:53,940 --> 00:14:58,500
+if the time relationship is clear don't use what?
+
+156
+00:14:59,220 --> 00:15:02,860
+the perfect yeah read the other sentence please
+
+157
+00:15:02,860 --> 00:15:07,040
+okay
+
+158
+00:15:07,040 --> 00:15:12,260
+thank you now is the time relationship clear
+
+159
+00:15:12,260 --> 00:15:15,840
+between the two verbs?when do you usually go to
+
+160
+00:15:15,840 --> 00:15:18,460
+bed while you are having the guests you say good
+
+161
+00:15:18,460 --> 00:15:20,840
+night my guests I'm going to bed and you leave
+
+162
+00:15:20,840 --> 00:15:27,500
+them okay so one stops one is completed the other
+
+163
+00:15:27,500 --> 00:15:34,480
+what okay yeah so again go on the two sentences so
+
+164
+00:15:34,480 --> 00:15:37,860
+it is not necessary to say after the guests had
+
+165
+00:15:37,860 --> 00:15:43,870
+leftOkay the past perfect is not needed it is not
+
+166
+00:15:43,870 --> 00:15:48,530
+needed unnecessary in this sentence again because
+
+167
+00:15:48,530 --> 00:15:52,430
+the time relationship between the two actions is
+
+168
+00:15:52,430 --> 00:15:56,210
+what clear okay yes
+
+169
+00:15:57,740 --> 00:16:00,660
+when we use after or before the time relationship
+
+170
+00:16:00,660 --> 00:16:05,320
+is clear okay so if the time relation and what do
+
+171
+00:16:05,320 --> 00:16:07,700
+you mean by clear you know which happened first
+
+172
+00:16:07,700 --> 00:16:10,980
+and which happened next right and we use the past
+
+173
+00:16:10,980 --> 00:16:13,820
+perfect also to show which happened first and
+
+174
+00:16:13,820 --> 00:16:18,120
+which happened next right so it is not necessary
+
+175
+00:16:18,120 --> 00:16:21,680
+to use the past perfect with after and before not
+
+176
+00:16:21,680 --> 00:16:29,830
+always what do you mean by at allall the time we
+
+177
+00:16:29,830 --> 00:16:32,570
+must use the past simple because the time
+
+178
+00:16:32,570 --> 00:16:36,150
+relationship okay if the past simple conveys your
+
+179
+00:16:36,150 --> 00:16:39,190
+message gives you a complete meaning don't use the
+
+180
+00:16:39,190 --> 00:16:42,670
+perfect right you don't need it try to use the
+
+181
+00:16:42,670 --> 00:16:47,510
+simple now we use the tenses to clear to convey a
+
+182
+00:16:47,510 --> 00:16:50,890
+certain message we said why why do we learn
+
+183
+00:16:50,890 --> 00:16:56,810
+grammarلكي تكتب و تتكلم بشكل جيد، أليس كذلك؟ إذا
+
+184
+00:16:56,810 --> 00:17:01,450
+كنت أستطيع أن أعطي رسالتي للقرار أو للمستمع،
+
+185
+00:17:01,450 --> 00:17:04,750
+فاستخدم السمبل إذا كنت بحاجة إلى الـ Progressive،
+
+186
+00:17:04,750 --> 00:17:06,870
+فأستخدم الـ Progressive إذا كنت بحاجة إلى الـ
+
+187
+00:17:06,870 --> 00:17:12,430
+Perfect، فأستخدم الـ Perfect وما إلى ذلك، إذا كنت
+
+188
+00:17:12,430 --> 00:17:17,610
+تعطي رسالتك بمجرد السمبل، فلا تستخدم الـ Perfect
+
+189
+00:17:23,650 --> 00:17:28,690
+read please if either before or after is used in
+
+190
+00:17:28,690 --> 00:17:31,810
+the sentence the past perfect is okay not
+
+191
+00:17:31,810 --> 00:17:35,310
+necessary yeah not necessary because yeah the time
+
+192
+00:17:35,310 --> 00:17:38,390
+relationship is already clear the simple past
+
+193
+00:17:38,390 --> 00:17:42,750
+maybe used for both thank you we use the simple
+
+194
+00:17:42,750 --> 00:17:46,730
+past and the simple past now talk about yourselves
+
+195
+00:17:46,730 --> 00:17:50,390
+tell me tell me yeah use the simple and the simple
+
+196
+00:17:50,390 --> 00:17:51,670
+with after and before
+
+197
+00:17:54,730 --> 00:17:59,930
+yes please I
+
+198
+00:17:59,930 --> 00:18:05,450
+ate my breakfast before I left I ate my breakfast
+
+199
+00:18:05,450 --> 00:18:09,630
+thank you good yes Marwa after I reached the
+
+200
+00:18:09,630 --> 00:18:14,470
+university I rushed to the class after I reached I
+
+201
+00:18:14,470 --> 00:18:17,350
+rushed to the class very good thank you go on go
+
+202
+00:18:17,350 --> 00:18:21,590
+on other examples yes tell me about yourself after
+
+203
+00:18:21,590 --> 00:18:23,050
+I reached I rushed yeah
+
+204
+00:18:26,580 --> 00:18:29,780
+Okay before I slept I written my homework good
+
+205
+00:18:29,780 --> 00:18:36,380
+thank you very much yeah before I
+
+206
+00:18:36,380 --> 00:18:40,780
+went I kissed my mother good thank you yeah before
+
+207
+00:18:40,780 --> 00:18:43,800
+I
+
+208
+00:18:43,800 --> 00:18:46,280
+went I brushed my teeth thank you very much so
+
+209
+00:18:46,280 --> 00:18:50,060
+again the time relationship is clear between the
+
+210
+00:18:50,060 --> 00:18:55,780
+two actions so the symbol and the symbolis okay is
+
+211
+00:18:55,780 --> 00:19:00,340
+enough yeah read
+
+212
+00:19:00,340 --> 00:19:05,920
+please the other example thank
+
+213
+00:19:05,920 --> 00:19:13,060
+you now علي didn't go to the movies with us he had
+
+214
+00:19:13,060 --> 00:19:18,760
+seen it he had seen it okay is it a good grammar
+
+215
+00:19:18,760 --> 00:19:22,920
+yesdoes it give you a good meaning? okay now when
+
+216
+00:19:22,920 --> 00:19:27,280
+I say he had already seen he had already seen
+
+217
+00:19:27,280 --> 00:19:32,220
+already what? emphasizes very good emphasizes the
+
+218
+00:19:32,220 --> 00:19:35,760
+meaning okay it emphasizes the meaning go on
+
+219
+00:19:35,760 --> 00:19:39,500
+please read the other one yeah I saw the film last
+
+220
+00:19:39,500 --> 00:19:43,500
+night I had never seen it before I had never seen
+
+221
+00:19:43,500 --> 00:19:47,600
+never again emphasizes what? the meaning thank you
+
+222
+00:19:47,600 --> 00:19:47,840
+yeah
+
+223
+00:19:55,870 --> 00:20:01,150
+Okay thank you now we know which happened first
+
+224
+00:20:01,150 --> 00:20:05,050
+again to emphasize the idea to emphasize the
+
+225
+00:20:05,050 --> 00:20:09,190
+meaning of the past perfect use these words to
+
+226
+00:20:09,190 --> 00:20:14,370
+emphasize the meaning where
+
+227
+00:20:14,370 --> 00:20:20,240
+are your keys where are your keys you lost themshe
+
+228
+00:20:20,240 --> 00:20:26,640
+lost her keys okay she lost her keys yes where are
+
+229
+00:20:26,640 --> 00:20:31,840
+your keys listen to her I lost my keys okay she
+
+230
+00:20:31,840 --> 00:20:37,120
+says I lost my keys what did she say she said that
+
+231
+00:20:37,120 --> 00:20:40,780
+she had lost very good she said that she had lost
+
+232
+00:20:40,780 --> 00:20:46,350
+repeat your words again pleaseyes I lost my keys
+
+233
+00:20:46,350 --> 00:20:50,030
+she says again what did she say she said that she
+
+234
+00:20:50,030 --> 00:20:53,650
+had lost her keys so in the reported speech we use
+
+235
+00:20:53,650 --> 00:20:57,350
+what the past perfect okay read the examples
+
+236
+00:20:57,350 --> 00:21:03,210
+please I lost my keys go on repeated word مولا
+
+237
+00:21:03,210 --> 00:21:08,510
+said that she had lost her keys good thank you
+
+238
+00:21:08,510 --> 00:21:13,910
+yeah go on read
+
+239
+00:21:27,940 --> 00:21:34,660
+Okay thank you, good Now
+
+240
+00:21:37,470 --> 00:21:42,210
+هذه صورة من الكتابة صورة من الكتابة تحب القصص و
+
+241
+00:21:42,210 --> 00:21:47,430
+القصص و القصص و القصص و القصص و القصص و قصص و قصص
+
+242
+00:21:47,430 --> 00:21:48,630
+و قصص و قصص و قصص و قصص و قصص و قصص و قصص و قصص و
+
+243
+00:21:48,630 --> 00:21:48,770
+قصص و قصص و قصص و قصص و قصص و قصص و قصص و قصص و
+
+244
+00:21:48,770 --> 00:21:50,310
+قصص و قصص و قصص و قصص و قصص و قصص و قصص و قصص و
+
+245
+00:21:50,310 --> 00:21:51,810
+قصص و قصص و قصص و قصص و قصص و قصص و قصص و قصص و
+
+246
+00:21:51,810 --> 00:21:56,630
+قصص و قصص و قصص و قصص و قصص و قصص و قصص و قصص و
+
+247
+00:21:56,630 --> 00:22:02,850
+قصص و قصص و
+
+248
+00:22:02,850 --> 00:22:06,070
+قصص
+
+249
+00:22:06,240 --> 00:22:09,460
+it had been a nearly perfect vacation day thank
+
+250
+00:22:09,460 --> 00:22:15,280
+you very much now listen the writer used what the
+
+251
+00:22:15,280 --> 00:22:18,480
+past perfect and the past perfect and the past
+
+252
+00:22:18,480 --> 00:22:23,140
+perfect بالفلت great okay the past simple felt
+
+253
+00:22:23,140 --> 00:22:27,790
+great why?The writer wants to tell you why did why
+
+254
+00:22:27,790 --> 00:22:32,850
+did he feel so okay so some actions happened
+
+255
+00:22:32,850 --> 00:22:36,630
+before and as a result of the actions how did he
+
+256
+00:22:36,630 --> 00:22:40,740
+feelOkay what did he use to convey that message to
+
+257
+00:22:40,740 --> 00:22:45,220
+the reader؟ he used what؟ the past perfect he used
+
+258
+00:22:45,220 --> 00:22:49,340
+the past perfect so the past perfect is used in
+
+259
+00:22:49,340 --> 00:22:52,660
+formal writing this is a piece of formal writing
+
+260
+00:22:52,660 --> 00:22:57,120
+okay a lot of writers use it to emphasize the idea
+
+261
+00:22:57,120 --> 00:23:03,140
+okay read please the past perfect is often found
+
+262
+00:23:04,700 --> 00:23:10,320
+formal writing such as what؟ good go on in the
+
+263
+00:23:10,320 --> 00:23:14,180
+above sentence in the fiction the writer uses the
+
+264
+00:23:14,180 --> 00:23:17,740
+simple past to say that an event happened in the
+
+265
+00:23:17,740 --> 00:23:23,480
+fifth degree and .. and the actor uses the past
+
+266
+00:23:23,480 --> 00:23:26,860
+basic to explain what .. what had happened before
+
+267
+00:23:26,860 --> 00:23:31,340
+that eventthank you good so he felt great why
+
+268
+00:23:31,340 --> 00:23:35,760
+because he had caught he had seen he had had okay
+
+269
+00:23:35,760 --> 00:23:39,840
+explaining what happened before so feeling happy
+
+270
+00:23:39,840 --> 00:23:43,260
+is a result of some actions what happened before
+
+271
+00:23:43,260 --> 00:23:48,300
+then he felt great okay would you read please yeah
+
+272
+00:23:55,470 --> 00:24:00,570
+what's that what would you say about that this is
+
+273
+00:24:00,570 --> 00:24:05,570
+the short form the contraction okay contracted
+
+274
+00:24:05,570 --> 00:24:09,350
+form so you can make contractions with had in the
+
+275
+00:24:09,350 --> 00:24:15,350
+past perfect okay again please go on read
+
+276
+00:24:17,560 --> 00:24:22,200
+contracted with personal pronouns in informal
+
+277
+00:24:22,200 --> 00:24:29,160
+writing not I'd finished, I'd .. I had look I'd
+
+278
+00:24:29,160 --> 00:24:35,780
+finished means what I had but I'd like I I would
+
+279
+00:24:35,780 --> 00:24:40,980
+okay now would and had are contracted in the same
+
+280
+00:24:40,980 --> 00:24:46,380
+wayOkay I'd like it means what I would like but
+
+281
+00:24:46,380 --> 00:24:52,260
+I'd finished I had good We
+
+282
+00:24:52,260 --> 00:24:56,620
+want to make a quick summary for the past perfect
+
+283
+00:24:56,620 --> 00:25:00,060
+What did we talk about yes tell me what did you
+
+284
+00:25:00,060 --> 00:25:04,080
+know about the past perfect now دعاء The past
+
+285
+00:25:04,080 --> 00:25:09,620
+perfect is an activity complete before another
+
+286
+00:25:09,620 --> 00:25:13,740
+activitygood thank you very much tell me another
+
+287
+00:25:13,740 --> 00:25:23,920
+point about the past perfect yes please okay
+
+288
+00:25:23,920 --> 00:25:26,980
+when the relationship between the two actions is
+
+289
+00:25:26,980 --> 00:25:30,780
+it clear okay we use what the simple past and the
+
+290
+00:25:30,780 --> 00:25:33,400
+simple past not the perfect thank you very much
+
+291
+00:25:33,400 --> 00:25:33,660
+good
+
+292
+00:25:39,170 --> 00:25:45,290
+thank you very much good yes بسمع good
+
+293
+00:25:45,290 --> 00:25:50,610
+thank you thank
+
+294
+00:25:50,610 --> 00:25:53,670
+you
+
+295
+00:25:53,670 --> 00:26:01,250
+very much to emphasize the action yeah very
+
+296
+00:26:01,250 --> 00:26:05,250
+good thank you very much now listen when we say
+
+297
+00:26:05,250 --> 00:26:13,620
+had visited had boughthad eaten had written do you
+
+298
+00:26:13,620 --> 00:26:17,960
+think there was a continuity or a duration for the
+
+299
+00:26:17,960 --> 00:26:21,400
+action in the past do you think there was a
+
+300
+00:26:21,400 --> 00:26:28,180
+duration when when i say the boss had left when i
+
+301
+00:26:28,180 --> 00:26:34,660
+arrived had left yeahno duration okay sometimes I
+
+302
+00:26:34,660 --> 00:26:38,320
+am interested in the continuity of the action in
+
+303
+00:26:38,320 --> 00:26:42,340
+the duration of the action okay now if you want to
+
+304
+00:26:42,340 --> 00:26:45,680
+tell me about yourself before you came to the
+
+305
+00:26:45,680 --> 00:26:52,370
+universityكل يوم كنت تقعد بسرعة تأخذ حقيبتك تذهب
+
+306
+00:26:52,370 --> 00:26:59,150
+للدراسة تجلس في الدراسة تستمع للعلماء تكتب قطع ثم
+
+307
+00:26:59,150 --> 00:27:05,810
+تحمل حقيبتك مرة أخرى كم وقت تستمر ذلك؟ 12 سنة 12
+
+308
+00:27:05,810 --> 00:27:13,730
+سنة الان إذا كنت تريد أن تتكلم عن نفسك تقول انا
+
+309
+00:27:13,730 --> 00:27:16,070
+انا
+
+310
+00:27:16,910 --> 00:27:31,310
+had been going to school for what? twelve years
+
+311
+00:27:31,310 --> 00:27:37,290
+okay now it's going to school like eating a
+
+312
+00:27:37,290 --> 00:27:42,430
+sandwich for example I had eatenAre they the same؟
+
+313
+00:27:42,430 --> 00:27:45,230
+No. Now the duration of the action is important
+
+314
+00:27:45,230 --> 00:27:49,390
+here. Twelve years it means I had been going to
+
+315
+00:27:49,390 --> 00:27:53,430
+school for twelve years before I joined the
+
+316
+00:27:53,430 --> 00:27:56,950
+university. Before I joined. So you joined the
+
+317
+00:27:56,950 --> 00:28:01,110
+university and you had been going to schoolthe
+
+318
+00:28:01,110 --> 00:28:05,790
+other .. the first action started continued in the
+
+319
+00:28:05,790 --> 00:28:09,850
+past okay there was continuity duration for the
+
+320
+00:28:09,850 --> 00:28:14,070
+action then another action started which is what
+
+321
+00:28:14,070 --> 00:28:19,390
+joining the school now yeah you joining the
+
+322
+00:28:19,390 --> 00:28:20,030
+university
+
+323
+00:28:36,120 --> 00:28:45,080
+read the example please yes تفضلي thank you
+
+324
+00:28:45,080 --> 00:28:52,580
+very much good look علي finally came I was waiting
+
+325
+00:28:52,580 --> 00:28:56,880
+علي I became very tired of waiting do you like
+
+326
+00:28:56,880 --> 00:29:02,100
+waiting no nobody likes waiting okay finally came
+
+327
+00:29:02,100 --> 00:29:08,010
+I had been waitingI had been waiting what do you
+
+328
+00:29:08,010 --> 00:29:11,950
+understand I had been waiting
+
+329
+00:29:14,850 --> 00:29:19,090
+was continuous okay was in progress in the past
+
+330
+00:29:19,090 --> 00:29:24,130
+okay so I had been waiting علي it was very
+
+331
+00:29:24,130 --> 00:29:28,070
+difficult for me okay I had been waiting for علي
+
+332
+00:29:28,070 --> 00:29:32,550
+since so and so so again I want to show the
+
+333
+00:29:32,550 --> 00:29:36,830
+duration that the action was in progress so I say
+
+334
+00:29:36,830 --> 00:29:42,460
+I had been waitingالأن علي أخيرًا أتي، علي أتي،
+
+335
+00:29:42,460 --> 00:29:48,420
+ولكن قبل أن يأتي، أنا كنت أنتظر، ودورة الحركة،
+
+336
+00:29:48,420 --> 00:29:53,820
+التابع للحركة في الماضي كانت مهمة، شكرا، قرأ بفضل
+
+337
+00:29:53,820 --> 00:29:58,640
+الواحد الأخر، نعم قرأ نعم، for
+
+338
+00:30:06,720 --> 00:30:15,680
+had been locking day and night in every place
+
+339
+00:30:19,460 --> 00:30:24,140
+Okay they caught him yeah they caught him so again
+
+340
+00:30:24,140 --> 00:30:28,700
+there was a duration for the action in the past
+
+341
+00:30:28,700 --> 00:30:32,680
+there was continuity the action was in a progress
+
+342
+00:30:32,680 --> 00:30:36,020
+before another action started the first action
+
+343
+00:30:36,020 --> 00:30:41,640
+which was in a progress is what had been looking
+
+344
+00:30:41,640 --> 00:30:46,270
+okay then what what happened thenthey caught him
+
+345
+00:30:46,270 --> 00:31:00,330
+good thank you yes please تفضلي read a duration
+
+346
+00:31:00,330 --> 00:31:03,470
+thank
+
+347
+00:31:03,470 --> 00:31:07,890
+you a duration of an activity emphasizes the
+
+348
+00:31:07,890 --> 00:31:11,570
+duration of an activity we are talking again about
+
+349
+00:31:11,570 --> 00:31:13,430
+the bus أسمح go on
+
+350
+00:31:17,580 --> 00:31:30,500
+thank you okay
+
+351
+00:31:30,500 --> 00:31:35,480
+good the other tenses are used more than the
+
+352
+00:31:35,480 --> 00:31:38,380
+perfect the past perfect progressive it is not
+
+353
+00:31:38,380 --> 00:31:41,280
+very common but it is a good tense and it is used
+
+354
+00:31:41,280 --> 00:31:47,740
+but not very common tenseyes please read the
+
+355
+00:31:47,740 --> 00:31:59,620
+example the runners
+
+356
+00:31:59,620 --> 00:32:05,380
+okay
+
+357
+00:32:05,380 --> 00:32:08,840
+good
+
+358
+00:32:08,840 --> 00:32:13,660
+thank you now look at this sentence the runners
+
+359
+00:32:13,660 --> 00:32:18,540
+had been runningthe runners had been running
+
+360
+00:32:22,010 --> 00:32:26,370
+tense tell me anything about the result what
+
+361
+00:32:26,370 --> 00:32:29,510
+happened then is it did can i understand what
+
+362
+00:32:29,510 --> 00:32:32,610
+happened with the runners did they stop did they
+
+363
+00:32:32,610 --> 00:32:38,230
+go on okay did they continue no so the progressive
+
+364
+00:32:38,230 --> 00:32:42,570
+here emphasizes what the process not the result
+
+365
+00:32:42,570 --> 00:32:46,570
+not interested we cannot so how can we know
+
+366
+00:32:46,570 --> 00:32:50,160
+something about the resulthow can we know
+
+367
+00:32:50,160 --> 00:32:53,140
+something about the result؟ look please read the
+
+368
+00:32:53,140 --> 00:32:56,580
+other sentence علي had been running for two hours
+
+369
+00:32:56,580 --> 00:33:01,180
+ten minutes and twenty nine seconds when he
+
+370
+00:33:01,180 --> 00:33:04,260
+crossed the finished line good now the finished
+
+371
+00:33:04,260 --> 00:33:10,650
+line the finished line tells you what?stopped okay
+
+372
+00:33:10,650 --> 00:33:14,970
+so it tells me something about the end result
+
+373
+00:33:14,970 --> 00:33:19,350
+that's right now did the tense tell me something
+
+374
+00:33:19,350 --> 00:33:23,970
+about the end result the tense is it the tense did
+
+375
+00:33:23,970 --> 00:33:27,770
+I did I understand this from the tense or from the
+
+376
+00:33:27,770 --> 00:33:34,220
+contextfrom the context okay the context now in
+
+377
+00:33:34,220 --> 00:33:37,600
+the first sentence you know i cannot understand i
+
+378
+00:33:37,600 --> 00:33:40,520
+cannot know anything about the result the
+
+379
+00:33:40,520 --> 00:33:45,260
+progressive emphasizes the action but here i can
+
+380
+00:33:45,260 --> 00:33:47,400
+know something about the end result because
+
+381
+00:33:47,400 --> 00:33:50,860
+something is mentioned he crossed the finish line
+
+382
+00:33:50,860 --> 00:33:54,980
+okay go on please read notice
+
+383
+00:34:03,000 --> 00:34:13,940
+thank you good now when I say it
+
+384
+00:34:13,940 --> 00:34:20,680
+was raining when I left my houseit was raining
+
+385
+00:34:20,680 --> 00:34:25,600
+when I left my house and it had been raining when
+
+386
+00:34:25,600 --> 00:34:29,900
+I left my house okay what's the difference between
+
+387
+00:34:29,900 --> 00:34:35,300
+the two sentences think of that again it was
+
+388
+00:34:35,300 --> 00:34:40,520
+raining when I left my house it had been raining
+
+389
+00:34:40,520 --> 00:34:45,000
+when I left my house in the first sentence did I
+
+390
+00:34:45,000 --> 00:34:51,830
+get wetyes did I walk under the rain yes okay so
+
+391
+00:34:51,830 --> 00:34:58,430
+the rain was okay it had been raining okay the
+
+392
+00:34:58,430 --> 00:35:03,490
+streets were wet right but did I go under the rain
+
+393
+00:35:03,490 --> 00:35:07,870
+no thank you read please the first sentence when
+
+394
+00:35:07,870 --> 00:35:10,930
+the rain started it was raining and the streets
+
+395
+00:35:10,930 --> 00:35:16,390
+were wet it was still raininggood look past
+
+396
+00:35:16,390 --> 00:35:20,630
+progressive it was still raining during the race
+
+397
+00:35:20,630 --> 00:35:25,030
+go on when the race started it had been raining
+
+398
+00:35:25,030 --> 00:35:28,690
+and the streets were wet it wasn't raining during
+
+399
+00:35:28,690 --> 00:35:33,350
+the race it had already stopped very good again
+
+400
+00:35:33,350 --> 00:35:37,550
+what is the difference between the two sentences
+
+401
+00:35:37,550 --> 00:35:40,510
+who can repeat who can repeat
+
+402
+00:35:43,330 --> 00:35:46,810
+yes please ماروة when we .. when we .. when we use
+
+403
+00:35:46,810 --> 00:35:50,930
+the past .. the past progressive it showed that
+
+404
+00:35:50,930 --> 00:35:54,830
+the action finished before .. sorry it showed that
+
+405
+00:35:54,830 --> 00:35:58,230
+the action was continuing when I left when I were
+
+406
+00:35:58,230 --> 00:36:03,610
+when I ..I'm talking about the example but in the
+
+407
+00:36:03,610 --> 00:36:08,210
+second example that you said the rain was stopped
+
+408
+00:36:08,210 --> 00:36:11,530
+or already stopped when the .. when the .. when I
+
+409
+00:36:11,530 --> 00:36:14,610
+left home so I didn't .. I didn't pay attention
+
+410
+00:36:14,610 --> 00:36:17,010
+thank you very much you remember when you went
+
+411
+00:36:17,010 --> 00:36:20,110
+home yesterday remember what happened with you
+
+412
+00:36:20,110 --> 00:36:24,170
+okay when you went home your father was sleeping
+
+413
+00:36:24,170 --> 00:36:30,200
+when you arrived your father was sleepingwas
+
+414
+00:36:30,200 --> 00:36:33,620
+sleeping sorry you are right when you arrived your
+
+415
+00:36:33,620 --> 00:36:36,840
+father was sleeping did you talk to him when you
+
+416
+00:36:36,840 --> 00:36:42,720
+arrived no he was sleeping now but if you say when
+
+417
+00:36:42,720 --> 00:36:46,020
+i arrived the other day my father had been
+
+418
+00:36:46,020 --> 00:36:51,160
+sleeping could you talk to him at that day had
+
+419
+00:36:51,160 --> 00:36:56,760
+been sleepingyes of course he had been sleeping
+
+420
+00:36:56,760 --> 00:37:01,460
+when I arrived he had been sleeping and he opened
+
+421
+00:37:01,460 --> 00:37:04,760
+the door for me when I arrived and I talked to him
+
+422
+00:37:04,760 --> 00:37:08,880
+but when I arrived he was sleeping I could not
+
+423
+00:37:08,880 --> 00:37:18,520
+talk to him he was sleeping okay read
+
+424
+00:37:18,520 --> 00:37:24,830
+please the other sentence نورher hair was still
+
+425
+00:37:24,830 --> 00:37:28,870
+wet because she had been swimming very good now
+
+426
+00:37:28,870 --> 00:37:36,030
+مونا got home her hair was still wet why she had
+
+427
+00:37:36,030 --> 00:37:43,630
+been swimming she had been swimming now got home
+
+428
+00:37:43,630 --> 00:37:48,050
+and had been swimming was this action completed
+
+429
+00:37:48,050 --> 00:37:53,740
+when the other action started yeswas it completed?
+
+430
+00:37:54,120 --> 00:37:58,860
+yes of course it was completed but when? when?
+
+431
+00:37:59,620 --> 00:38:06,120
+which past? which past? thank you in the immediate
+
+432
+00:38:06,120 --> 00:38:10,580
+past very good there was a short time just before
+
+433
+00:38:10,580 --> 00:38:15,900
+still her hair was wet okay read please the other
+
+434
+00:38:15,900 --> 00:38:16,320
+sentence
+
+435
+00:38:21,310 --> 00:38:25,290
+فنورال؟ نعم كان يبقى أحمر لأنه كان يبقى يبقى يبقى
+
+436
+00:38:25,290 --> 00:38:26,170
+يبقى يبقى يبقى يبقى يبقى يبقى يبقى يبقى يبقى يبقى
+
+437
+00:38:26,170 --> 00:38:30,090
+يبقى يبقى يبقى يبقى يبقى يبقى يبقى يبقى يبقى يبقى
+
+438
+00:38:30,090 --> 00:38:30,630
+يبقى يبقى يبقى يبقى يبقى يبقى يبقى يبقى يبقى يبقى
+
+439
+00:38:30,630 --> 00:38:32,030
+يبقى يبقى يبقى يبقى يبقى يبقى يبقى يبقى يبقى يبقى
+
+440
+00:38:32,030 --> 00:38:40,270
+يبقى يبقى يبقى يبقى يبقى يبقى يبقى يبقى
+
+441
+00:38:40,270 --> 00:38:48,730
+ي
+
+442
+00:38:48,880 --> 00:38:53,920
+very good okay activity in a progressive clause in
+
+443
+00:38:53,920 --> 00:38:58,520
+time to another activity when she got home she had
+
+444
+00:38:58,520 --> 00:39:02,320
+been sleeping she had been swimming a clause in
+
+445
+00:39:02,320 --> 00:39:05,360
+time to the other activity I have two activities
+
+446
+00:39:05,360 --> 00:39:13,080
+the other one is a clause in time now read yes
+
+447
+00:39:13,080 --> 00:39:13,440
+please
+
+448
+00:39:21,630 --> 00:39:27,030
+thank you very much again this tense is also used
+
+449
+00:39:27,030 --> 00:39:31,890
+in the reported speech yeah you want to ask you
+
+450
+00:39:31,890 --> 00:39:37,790
+want to ask now
+
+451
+00:39:37,790 --> 00:39:42,830
+let's sum up quickly what did we say about the
+
+452
+00:39:42,830 --> 00:39:49,400
+past perfect progressivewhat did we say؟ yeah who
+
+453
+00:39:49,400 --> 00:39:53,120
+can give me something? give me a point what did we
+
+454
+00:39:53,120 --> 00:39:59,960
+say about the progressive? سُهَة passed
+
+455
+00:39:59,960 --> 00:40:01,000
+perfect to progressive
+
+456
+00:40:05,950 --> 00:40:08,530
+Okay, we are interested in the duration, there was
+
+457
+00:40:08,530 --> 00:40:12,910
+a duration, they were in a progress before another
+
+458
+00:40:12,910 --> 00:40:15,710
+action happened. Very good. Thank you. Yes.
+
+459
+00:40:21,370 --> 00:40:27,250
+Very good. Thank you very much. Yes, please, Lama.
+
+460
+00:40:35,380 --> 00:40:38,480
+Okay it is used in the reported speech also thank
+
+461
+00:40:38,480 --> 00:40:43,700
+you yes please okay
+
+462
+00:40:43,700 --> 00:40:46,940
+thank you emphasizes the action you mean thank you
+
+463
+00:40:46,940 --> 00:40:50,400
+good good you remember when we talked about the
+
+464
+00:40:50,400 --> 00:40:53,320
+present perfect progressive and the present
+
+465
+00:40:53,320 --> 00:40:57,800
+perfect okay which tense okay tells us or
+
+466
+00:40:57,800 --> 00:41:00,040
+emphasizes the result not the action the
+
+467
+00:41:00,040 --> 00:41:01,300
+progressive or the perfect
+
+468
+00:41:04,000 --> 00:41:08,260
+yes the perfect and the progressive emphasizes the
+
+469
+00:41:08,260 --> 00:41:11,500
+action emphasizes I'm interested in the action
+
+470
+00:41:11,500 --> 00:41:14,500
+more than the result when I use the progressive
+
+471
+00:41:14,500 --> 00:41:16,480
+okay thank you very much
+
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/3csAdG_Imio_postprocess.srt b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/3csAdG_Imio_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..7a9c6145e84a459ec1f6b75057e7aa033251dc5a
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/3csAdG_Imio_postprocess.srt
@@ -0,0 +1,1424 @@
+1
+00:00:21,130 --> 00:00:25,670
+good morning to you all how are you? I hope you
+
+2
+00:00:25,670 --> 00:00:30,630
+are feeling well today with your exams you should
+
+3
+00:00:30,630 --> 00:00:34,650
+you should even if you have exams feel well think
+
+4
+00:00:34,650 --> 00:00:38,690
+okay don't think too much of that ياسمين can you
+
+5
+00:00:38,690 --> 00:00:45,890
+give me your pen please your pen thank
+
+6
+00:00:45,890 --> 00:00:54,010
+you this is ياسمين's pencilyes means pencil okay
+
+7
+00:00:54,010 --> 00:01:01,290
+thank you yes means pencil Najwa where is your
+
+8
+00:01:01,290 --> 00:01:05,430
+book where
+
+9
+00:01:05,430 --> 00:01:10,330
+is your book okay yes what's that can you tell me
+
+10
+00:01:10,330 --> 00:01:14,540
+what's that سحرit is najwa's book thank you very
+
+11
+00:01:14,540 --> 00:01:21,760
+much good it is najwa's book okay now دعاء has a
+
+12
+00:01:21,760 --> 00:01:28,140
+new pen what's that دعاء is pen now how can i
+
+13
+00:01:28,140 --> 00:01:31,740
+write yes means for example if i want to write
+
+14
+00:01:31,740 --> 00:01:35,920
+okay yes
+
+15
+00:01:35,920 --> 00:01:40,380
+means pen yes means pen look
+
+16
+00:01:49,700 --> 00:01:56,010
+yes means pen what do we callthis this is what
+
+17
+00:01:56,010 --> 00:01:59,290
+apostrophe very good thank you now let's agree
+
+18
+00:01:59,290 --> 00:02:05,770
+that this is apostrophe not comma not comma there
+
+19
+00:02:05,770 --> 00:02:09,530
+is yes a big difference between a comma and an
+
+20
+00:02:09,530 --> 00:02:13,590
+apostrophe so this is apostrophe and apostrophe is
+
+21
+00:02:13,590 --> 00:02:18,990
+used now we use look if you look at the nouns the
+
+22
+00:02:18,990 --> 00:02:25,050
+girl Tom my wife a lady and Thomaswe write .. we
+
+23
+00:02:25,050 --> 00:02:29,770
+want to express the positive case by writing .. by
+
+24
+00:02:29,770 --> 00:02:37,890
+writing what؟ by writing
+
+25
+00:02:37,890 --> 00:02:40,390
+an apostrophe and s you know I'm thinking of
+
+26
+00:02:40,390 --> 00:02:43,610
+something else okay there is a mistake here I
+
+27
+00:02:43,610 --> 00:02:47,890
+discovered a mistake this should be corrected this
+
+28
+00:02:47,890 --> 00:02:49,670
+is what؟
+
+29
+00:02:52,510 --> 00:02:57,870
+was the same form okay not noun okay so now the
+
+30
+00:02:57,870 --> 00:03:04,870
+girl the girls yeah Tom Tom's my wife my wives
+
+31
+00:03:04,870 --> 00:03:11,430
+yeaha lady a ladies how do we write a ladies now
+
+32
+00:03:11,430 --> 00:03:15,490
+look at this noun it ends with y it has nothing to
+
+33
+00:03:15,490 --> 00:03:18,330
+do with the spelling with the y okay this is not
+
+34
+00:03:18,330 --> 00:03:22,010
+for the plural remember if it is for a plural or
+
+35
+00:03:22,010 --> 00:03:25,090
+it is if it is with a verb we think whether we
+
+36
+00:03:25,090 --> 00:03:29,270
+have to keep the y or to change it but nowin these
+
+37
+00:03:29,270 --> 00:03:32,310
+nouns if you want to write the apostrophe s keep
+
+38
+00:03:32,310 --> 00:03:36,510
+it okay keep it whether it is preceded by a vowel
+
+39
+00:03:36,510 --> 00:03:42,150
+or a consonant good now look thomas is different
+
+40
+00:03:42,150 --> 00:03:47,050
+anas is different inas is also different they end
+
+41
+00:03:47,050 --> 00:03:50,810
+with what with s how can we write the possessive
+
+42
+00:03:50,810 --> 00:03:57,150
+casewe have two forms what are they؟
+
+43
+00:03:57,150 --> 00:04:01,570
+thank you very much you have two options you can
+
+44
+00:04:01,570 --> 00:04:05,990
+add apostrophe s or just apostrophe and they will
+
+45
+00:04:05,990 --> 00:04:15,070
+do okay now look at that this is right okay
+
+46
+00:04:18,170 --> 00:04:21,150
+Now what do you notice about these nouns؟ What do
+
+47
+00:04:21,150 --> 00:04:26,450
+you read please Khadija؟ The girls, the wives, the
+
+48
+00:04:26,450 --> 00:04:30,730
+men, the children Thank you very much Now we have
+
+49
+00:04:30,730 --> 00:04:35,450
+plural nounsand they include the two types of
+
+50
+00:04:35,450 --> 00:04:40,630
+plural regular and irregular look okay girls,
+
+51
+00:04:41,070 --> 00:04:46,150
+wives, ladies, men and children now how can we
+
+52
+00:04:46,150 --> 00:04:51,730
+write the apostrophe for these nouns yes saharyeah
+
+53
+00:04:51,730 --> 00:04:57,250
+add only apostrophe okay if we want if the noun
+
+54
+00:04:57,250 --> 00:05:01,650
+ends with s you remember thomas أنا سيناس we added
+
+55
+00:05:01,650 --> 00:05:06,170
+what apostrophe now this is also in this case we
+
+56
+00:05:06,170 --> 00:05:09,870
+add only apostrophe only apostrophe only
+
+57
+00:05:09,870 --> 00:05:15,770
+apostrophe but with men with irregular nouns you
+
+58
+00:05:15,770 --> 00:05:22,530
+add apostrophe s now i want to askهل تعتقد أن مقال
+
+59
+00:05:22,530 --> 00:05:30,650
+فقط يمكن أن يتم إضافه إلى رجال أو امرأة؟ لا ، انت
+
+60
+00:05:30,650 --> 00:05:34,870
+محق ، لكن لماذا؟ انهم ليسوا مقالين ، انهم ليسوا
+
+61
+00:05:34,870 --> 00:05:39,110
+مقالين ، هذا صحيح ، إنهم غير عادلين و لا ينتهي
+
+62
+00:05:39,110 --> 00:05:44,090
+أبداً بهذا ، حسنًا ، لكي يكونوا مقالين ، الآن مرة
+
+63
+00:05:44,090 --> 00:05:48,070
+أخرى ، نضيف مقال فقط لإصلاح
+
+64
+00:05:49,920 --> 00:05:56,420
+فارم or a possessive case let
+
+65
+00:05:56,420 --> 00:06:02,700
+me ask you now
+
+66
+00:06:02,700 --> 00:06:05,580
+how do we translate this
+
+67
+00:06:20,430 --> 00:06:24,130
+yes in Arabic in Arabic نور the first sentence
+
+68
+00:06:24,130 --> 00:06:27,310
+كتاب
+
+69
+00:06:27,310 --> 00:06:31,690
+البنت good كتاب البنت and the other one كتاب
+
+70
+00:06:31,690 --> 00:06:35,030
+البنات very good that's right okay it is one book
+
+71
+00:06:35,030 --> 00:06:37,850
+but this is singular and this is what plural very
+
+72
+00:06:37,850 --> 00:06:45,630
+good thank you very much good now
+
+73
+00:06:45,630 --> 00:06:52,030
+look at this sentence Alan and Lisathis house is
+
+74
+00:06:52,030 --> 00:06:57,770
+for Fatima and Ali we say it is Fatima and Ali's
+
+75
+00:06:57,770 --> 00:07:02,750
+house okay it is Fatima and Ali's house this bag
+
+76
+00:07:02,750 --> 00:07:08,250
+is for Khadija and Duait is خديجة and دعاق back
+
+77
+00:07:08,250 --> 00:07:12,990
+okay now look the house or the apartment is for
+
+78
+00:07:12,990 --> 00:07:18,490
+two people joined by what by and alan and ليزا we
+
+79
+00:07:18,490 --> 00:07:22,810
+say what yes ولا read the sentence
+
+80
+00:07:26,930 --> 00:07:31,790
+Okay, so we add the apostrophe s on the final noun
+
+81
+00:07:31,790 --> 00:07:35,110
+if they are joined or they are connected by what?
+
+82
+00:07:35,590 --> 00:07:40,490
+By and, good Now this is an exercise, I'll give
+
+83
+00:07:40,490 --> 00:07:44,390
+you three minutes to do this exercise, exercise
+
+84
+00:07:44,390 --> 00:07:47,570
+eight, please look at your box and do the exercise
+
+85
+00:07:58,270 --> 00:08:16,470
+أعتقد أن هذا كافي الأن تحقق إجابتك تحقق
+
+86
+00:08:16,470 --> 00:08:23,180
+إجابتك أي سؤال؟ من يريد أن يسأل؟الذي حصل على مقام
+
+87
+00:08:23,180 --> 00:08:35,060
+كامل، حقا، رائع، رائع، جيد، حسنًا، لا أسئلة،
+
+88
+00:08:35,060 --> 00:08:41,340
+انظر، هناك مجرم أخر، مجرم 8 ومجرم 9، مجرم أخر،
+
+89
+00:08:41,340 --> 00:08:48,020
+لديك 3 دقيقة لتفعل هذا المجرم، اذهب بفضل اللهcheck
+
+90
+00:08:48,020 --> 00:08:51,820
+your answers for three four and five check your
+
+91
+00:08:51,820 --> 00:08:55,820
+answers
+
+92
+00:08:55,820 --> 00:09:14,320
+any
+
+93
+00:09:14,320 --> 00:09:19,110
+questionwho got a full mark really wonderful very
+
+94
+00:09:19,110 --> 00:09:24,050
+good thank you please complete the other sentences
+
+95
+00:09:24,050 --> 00:09:29,390
+at home you have another four sentences okay and
+
+96
+00:09:29,390 --> 00:09:30,390
+you have the answers
+
+97
+00:09:37,050 --> 00:09:41,750
+العمل 10 نريد أيضًا أن نفعل هذه الفترة، فقط رقم 2
+
+98
+00:09:41,750 --> 00:09:47,590
+في عمل 10 سأعطيك فقط 1 دقيقة، انظر إلى عمل 10،
+
+99
+00:09:47,590 --> 00:09:51,370
+مجلة 106، وفعل رقم 2
+
+100
+00:10:15,700 --> 00:10:24,160
+الان اتفق على إجابتك نمبر اتفق
+
+101
+00:10:24,160 --> 00:10:28,760
+على إجابتك
+
+102
+00:10:28,760 --> 00:10:30,500
+نمبر اتفق على إجابتك نمبر اتفق على إجابتك نمبر
+
+103
+00:10:30,500 --> 00:10:30,720
+اتفق على إجابتك نمبر اتفق على إجابتك نمبر اتفق على
+
+104
+00:10:30,720 --> 00:10:30,760
+إجابتك نمبر اتفق على إجابتك نمبر اتفق على إجابتك
+
+105
+00:10:30,760 --> 00:10:31,220
+نمبر اتفق على إجابتك نمبر اتفق على إجابتك نمبر
+
+106
+00:10:31,220 --> 00:10:32,880
+اتفق على إجابتك نمبر اتفق على إجابتك نمبر اتفق على
+
+107
+00:10:32,880 --> 00:10:35,200
+إجابتك نمبر اتفق على إجابتك نمبر اتفق على إجابتك
+
+108
+00:10:35,200 --> 00:10:42,100
+نمبر اتفق على إجابتك نمبر
+
+109
+00:10:42,100 --> 00:10:44,480
+ا
+
+110
+00:10:51,140 --> 00:10:56,400
+الان انظر، من يقدر يقرأ هذه الصفة؟ نعم، أرجوك، قم
+
+111
+00:10:56,400 --> 00:11:02,240
+بقرأها السوق لديه بيجتابوتز فيه، إنه بيجتابوتز في
+
+112
+00:11:02,240 --> 00:11:07,900
+السوق. شكرا جزيلا. الصفة الأخرى، نعم، أرجوك، صحيح؟
+
+113
+00:11:07,900 --> 00:11:14,140
+السوق لديه مصرفين فيه، نعم، لديه مصرفين فيه، نعم،
+
+114
+00:11:14,140 --> 00:11:22,080
+شكرا جزيلا.office in general is a noun right in
+
+115
+00:11:22,080 --> 00:11:25,720
+this sentence if you say it is building or it is a
+
+116
+00:11:25,720 --> 00:11:29,440
+building what type of building is it we don't know
+
+117
+00:11:29,440 --> 00:11:34,990
+okay now what does this word doit describes the
+
+118
+00:11:34,990 --> 00:11:38,950
+noun. Now when I say it is an office building, so
+
+119
+00:11:38,950 --> 00:11:43,030
+this noun describes the other noun. So what does
+
+120
+00:11:43,030 --> 00:11:46,450
+the adjective do? The adjective describes the
+
+121
+00:11:46,450 --> 00:11:49,750
+noun. When I say wither, what type of wither? I
+
+122
+00:11:49,750 --> 00:11:52,450
+don't know. But when I say cold wither for
+
+123
+00:11:52,450 --> 00:11:56,290
+example, cold, the adjective describes the noun.
+
+124
+00:11:57,020 --> 00:12:01,220
+الأن في هذه الفيديوهات هذا الوضع يDescribe الوضع
+
+125
+00:12:01,220 --> 00:12:01,920
+اللي يسمّى الوضع اللي يسمّاه الوضع اللي يسمّاه
+
+126
+00:12:01,920 --> 00:12:03,220
+الوضع اللي يسمّاه الوضع اللي يسمّاه الوضع اللي
+
+127
+00:12:03,220 --> 00:12:06,020
+يسمّاه الوضع اللي يسمّاه الوضع اللي يسمّاه الوضع
+
+128
+00:12:06,020 --> 00:12:08,020
+اللي يسمّاه الوضع اللي يسمّاه الوضع اللي يسمّاه
+
+129
+00:12:08,020 --> 00:12:09,420
+الوضع اللي يسمّاه الوضع اللي يسمّاه الوضع اللي
+
+130
+00:12:09,420 --> 00:12:12,460
+يسمّاه الوضع اللي يسمّاه الوضع اللي يسمّاه الوضع
+
+131
+00:12:12,460 --> 00:12:17,080
+اللي يسمّاه الوضع اللي يسمّاه الوضع اللي يسمّاه
+
+132
+00:12:17,080 --> 00:12:21,300
+الوضع اللي
+
+133
+00:12:21,300 --> 00:12:25,160
+يسمّاه الوضع
+
+134
+00:12:25,160 --> 00:12:30,340
+الليit is in its singular in the in the main
+
+135
+00:12:30,340 --> 00:12:34,840
+sentence the building has what offices it offices
+
+136
+00:12:34,840 --> 00:12:38,980
+but this should be used with what singular and
+
+137
+00:12:38,980 --> 00:12:43,740
+office building and office building okay i have a
+
+138
+00:12:43,740 --> 00:12:49,000
+lot of flowers in my garden it is a flower garden
+
+139
+00:12:49,000 --> 00:12:54,790
+very good it is a flower gardenNow don't add S for
+
+140
+00:12:54,790 --> 00:12:59,450
+example to vegetable okay to office and so on
+
+141
+00:12:59,450 --> 00:13:06,450
+don't add the S Look at this sentence who can read
+
+142
+00:13:06,450 --> 00:13:14,050
+yes please و لا the test lasted
+
+143
+00:13:14,050 --> 00:13:21,830
+two hours okayOkay it was a two hour test a two
+
+144
+00:13:21,830 --> 00:13:27,590
+hour test now how long did it last how did we know
+
+145
+00:13:27,590 --> 00:13:34,430
+so again a two hour modified modifies the noun
+
+146
+00:13:34,430 --> 00:13:39,390
+okay describes the noun remember again we use what
+
+147
+00:13:41,190 --> 00:13:44,990
+So don't say it was two hours test. This is a
+
+148
+00:13:44,990 --> 00:13:49,070
+common mistake. A lot of students think since we
+
+149
+00:13:49,070 --> 00:13:52,910
+begin with two, we should add S. No, don't add S
+
+150
+00:13:56,750 --> 00:14:02,010
+أتو اوار تاست اتو اوار تاست it modifies the noun
+
+151
+00:14:02,010 --> 00:14:05,950
+look at the other sentence yes please read it
+
+152
+00:14:05,950 --> 00:14:10,730
+again
+
+153
+00:14:10,730 --> 00:14:16,270
+read it again she has a five-year-old very good
+
+154
+00:14:16,270 --> 00:14:20,930
+thank you very much okay and this again this is
+
+155
+00:14:20,930 --> 00:14:28,910
+whatwe use a hyphen when we use a noun a modifier
+
+156
+00:14:28,910 --> 00:14:32,350
+to describe the noun it should be hyphenated we
+
+157
+00:14:32,350 --> 00:14:35,650
+use hyphens and again remember to use what the
+
+158
+00:14:35,650 --> 00:14:40,570
+singular never use the plural okay yes read please
+
+159
+00:14:40,570 --> 00:14:45,010
+this note when a noun used as a modifier is
+
+160
+00:14:45,010 --> 00:14:48,530
+combined with a number expression the noun is
+
+161
+00:14:48,530 --> 00:14:53,000
+singular and pluralOkay a hyphen is used thank you
+
+162
+00:14:53,000 --> 00:14:59,380
+yes go on she has okay now look this is what this
+
+163
+00:14:59,380 --> 00:15:05,680
+is cancelled this is deleted look we don't use the
+
+164
+00:15:05,680 --> 00:15:11,550
+swe don't use this okay and again as i told you
+
+165
+00:15:11,550 --> 00:15:16,230
+this is a common mistake we use a a for singular
+
+166
+00:15:16,230 --> 00:15:21,150
+give me a book a book can i use a and s with the
+
+167
+00:15:21,150 --> 00:15:26,610
+same noun okay who
+
+168
+00:15:26,610 --> 00:15:32,030
+wants to ask who wants to ask who wants to answer
+
+169
+00:15:33,590 --> 00:15:36,750
+who wants to answer yes please yes me go on ال
+
+170
+00:15:36,750 --> 00:15:40,690
+hyphen is important to use yes of course before
+
+171
+00:15:40,690 --> 00:15:43,670
+nouns use it with modifiers they are called
+
+172
+00:15:43,670 --> 00:15:49,190
+modifiers they modify the nouns okay i want you to
+
+173
+00:15:49,190 --> 00:15:56,430
+answer somebody to answer اتفضلي my garden
+
+174
+00:15:56,430 --> 00:16:04,500
+has flowers in it okay has flowers in it sohas
+
+175
+00:16:04,500 --> 00:16:12,100
+flowers in it it is a flower garden thank you
+
+176
+00:16:12,100 --> 00:16:15,280
+complete the exercise complete it yourself please
+
+177
+00:16:15,280 --> 00:16:16,020
+it is easy
+
+178
+00:16:43,100 --> 00:16:53,380
+كم كنت تنتهي؟ خمس؟ خمس؟ خمس؟ خمس؟ خمس؟ خمس؟ خمس؟
+
+179
+00:16:53,380 --> 00:16:53,860
+خمس؟ خمس؟ خمس؟ خمس؟ خمس؟ خمس؟ خمس؟ خمس؟ خمس؟ خمس؟
+
+180
+00:16:53,860 --> 00:16:53,900
+خمس؟ خمس؟ خمس؟ خمس؟ خمس؟ خمس؟ خمس؟ خمس؟ خمس؟ خمس؟
+
+181
+00:16:53,900 --> 00:16:53,920
+خمس؟ خمس؟ خمس؟ خمس؟ خمس؟ خمس؟ خمس؟ خمس؟ خمس؟ خمس؟
+
+182
+00:16:53,920 --> 00:17:01,660
+خمس؟ خمس؟ خمس؟
+
+183
+00:17:01,660 --> 00:17:06,860
+خمس؟ خمس؟ خمس؟
+
+184
+00:17:06,860 --> 00:17:07,720
+خمس
+
+185
+00:17:20,760 --> 00:17:23,880
+Who can tell me what about this word mosquito why
+
+186
+00:17:23,880 --> 00:17:27,880
+written in two forms؟ why written in two forms؟
+
+187
+00:17:27,880 --> 00:17:35,700
+yes it ends with a so it can be okay thank you the
+
+188
+00:17:35,700 --> 00:17:40,420
+plural can be with s or es you are right good now
+
+189
+00:17:42,400 --> 00:17:48,260
+count and non-count nouns okay some books write
+
+190
+00:17:48,260 --> 00:17:51,880
+countable and non-countable nouns uncountable
+
+191
+00:17:51,880 --> 00:17:58,460
+nouns okay it is the same now how many box do you
+
+192
+00:17:58,460 --> 00:18:04,960
+have noor I have two box okay I have two box how
+
+193
+00:18:04,960 --> 00:18:09,310
+many pens do you haveI have one pen. Thank you.
+
+194
+00:18:10,090 --> 00:18:15,450
+Now how many bags do you have? How many bags do
+
+195
+00:18:15,450 --> 00:18:19,430
+you have دعا? How many bags do you have? One bag
+
+196
+00:18:19,430 --> 00:18:24,540
+okay. Now how many sisters do you have?I have two
+
+197
+00:18:24,540 --> 00:18:31,380
+sisters now sisters box okay bags friends we can
+
+198
+00:18:31,380 --> 00:18:35,360
+count them they are count nouns okay they are
+
+199
+00:18:35,360 --> 00:18:40,520
+count nouns and when i say for example i want a
+
+200
+00:18:40,520 --> 00:18:45,760
+book i have two books okay this is a count noun
+
+201
+00:18:45,760 --> 00:18:51,560
+when i say for example okay a book or i have two
+
+202
+00:18:52,400 --> 00:18:59,520
+box okay I used what the a in the singular and the
+
+203
+00:18:59,520 --> 00:19:03,440
+s for the plural okay we use the indefinite
+
+204
+00:19:03,440 --> 00:19:08,720
+articles I ate an apple I ate two apples we use
+
+205
+00:19:08,720 --> 00:19:12,760
+the indefinite article for the plural and the s
+
+206
+00:19:12,760 --> 00:19:17,320
+for for the singular and the s for the plural now
+
+207
+00:19:17,320 --> 00:19:26,800
+when I sayWater is essential for our life. It is
+
+208
+00:19:26,800 --> 00:19:27,760
+unkown.
+
+209
+00:19:30,940 --> 00:19:37,820
+And it is unlike count nouns. So we have two types
+
+210
+00:19:37,820 --> 00:19:42,420
+of nounsyes count and non count if you look at the
+
+211
+00:19:42,420 --> 00:19:46,020
+first sentence yes read it please I bought a chair
+
+212
+00:19:46,020 --> 00:19:51,720
+a chair yeah one it means a a chair one chair yes
+
+213
+00:19:51,720 --> 00:19:54,480
+Sam Sam bought three chairs thank you very much
+
+214
+00:19:54,480 --> 00:19:58,080
+now I have chair and chairs look a chair and
+
+215
+00:19:58,080 --> 00:20:01,080
+chairs okay thank you read the other sentence
+
+216
+00:20:01,080 --> 00:20:07,480
+pleasewe bought some furniture okay some furniture
+
+217
+00:20:07,480 --> 00:20:12,320
+now furniture and chair or chairs are different
+
+218
+00:20:12,320 --> 00:20:16,840
+okay i can i can count chair but i cannot count
+
+219
+00:20:16,840 --> 00:20:23,140
+furniture and grammatically chair accepts what the
+
+220
+00:20:23,140 --> 00:20:27,300
+indefinite article i say a chair right i say a
+
+221
+00:20:27,300 --> 00:20:31,940
+book i say chairs i say box right but furniture
+
+222
+00:20:32,880 --> 00:20:36,920
+doesn't accept the a doesn't accept the s right we
+
+223
+00:20:36,920 --> 00:20:41,380
+don't add a or s for furniture it is what a non
+
+224
+00:20:41,380 --> 00:20:46,140
+count now so we bought some furnitures again this
+
+225
+00:20:46,140 --> 00:20:50,120
+is not accepted with the s okay with the s it is
+
+226
+00:20:50,120 --> 00:20:54,680
+not accepted also we bought a furniture okay this
+
+227
+00:20:54,680 --> 00:20:59,140
+is not acceptedSo what is the main difference now
+
+228
+00:20:59,140 --> 00:21:03,240
+between count and non-count nouns according to
+
+229
+00:21:03,240 --> 00:21:06,940
+what we said؟
+
+230
+00:21:06,940 --> 00:21:13,860
+yes please count noun can be singular or plural
+
+231
+00:21:13,860 --> 00:21:20,600
+but not count can't
+
+232
+00:21:20,600 --> 00:21:25,400
+be underlined by singular or pluralThank you very
+
+233
+00:21:25,400 --> 00:21:30,060
+much now listen count and non count nouns to be
+
+234
+00:21:30,060 --> 00:21:36,680
+more accurate some non count nouns can be used as
+
+235
+00:21:36,680 --> 00:21:41,600
+count nouns okay non count can be used as count
+
+236
+00:21:41,600 --> 00:21:49,840
+for example when i say when i say meat meat
+
+237
+00:21:49,840 --> 00:21:55,270
+is it count or non countit is non count okay non
+
+238
+00:21:55,270 --> 00:21:59,430
+count noun but if i say the new supermarket has
+
+239
+00:21:59,430 --> 00:22:04,410
+several meats several meats different types of
+
+240
+00:22:04,410 --> 00:22:09,170
+meats right so i can say that the non count is
+
+241
+00:22:09,170 --> 00:22:12,910
+used as a count in this sentence okay because it
+
+242
+00:22:12,910 --> 00:22:16,990
+accepted what the s means this is for some not all
+
+243
+00:22:16,990 --> 00:22:23,400
+uncount nouns also when coffee for exampleit is
+
+244
+00:22:23,400 --> 00:22:27,440
+what non count but if your father says three
+
+245
+00:22:27,440 --> 00:22:33,020
+coffees please three coffees he used a non count
+
+246
+00:22:33,020 --> 00:22:37,920
+as a count okay but now what we mean here in these
+
+247
+00:22:37,920 --> 00:22:42,060
+sentences in general in general the non count
+
+248
+00:22:42,060 --> 00:22:45,740
+nouns don't accept the a for the singular and
+
+249
+00:22:45,740 --> 00:22:48,940
+don't accept the s for plural now look at the
+
+250
+00:22:48,940 --> 00:22:57,180
+examples count nounssingular and plural you know a
+
+251
+00:22:57,180 --> 00:23:01,980
+chair one chair two chairs some a lot many chairs
+
+252
+00:23:01,980 --> 00:23:06,900
+or chairs okay so again count nouns maybe preceded
+
+253
+00:23:06,900 --> 00:23:13,100
+by the indefinite article as you know and take s
+
+254
+00:23:13,100 --> 00:23:17,810
+or esWe talked about that. Now what about the non
+
+255
+00:23:17,810 --> 00:23:22,850
+-count nouns؟ I say some furniture. Can I add S؟
+
+256
+00:23:22,850 --> 00:23:27,960
+some furnitureA lot of furniture yeah much
+
+257
+00:23:27,960 --> 00:23:33,460
+furniture or okay so again they cannot be preceded
+
+258
+00:23:33,460 --> 00:23:39,240
+by a آية and they cannot they don't accept what
+
+259
+00:23:39,240 --> 00:23:43,660
+the plural is now look at this exercise you have
+
+260
+00:23:43,660 --> 00:23:47,280
+two minutes to do this exercise two please two
+
+261
+00:23:47,280 --> 00:23:53,620
+three and four you have two minutes okay
+
+262
+00:23:55,120 --> 00:23:59,840
+الان تحققوا إجابتك بفضل الله تحققوا إجابتك الآن
+
+263
+00:23:59,840 --> 00:24:06,100
+لدينا في السلسلة الأولى أجل أين المعنى؟ أجل هل هو
+
+264
+00:24:06,100 --> 00:24:11,480
+count او non-count؟ non-count ومعنى الأخر؟ رقم
+
+265
+00:24:11,480 --> 00:24:17,840
+count ومعنى هذا؟ رقم برسلت؟ نقم نقم نقم نقم نقم
+
+266
+00:24:17,840 --> 00:24:20,620
+نقم نقم نقم نقم نقم نقم نقم نقم نقم نقم نقم نقم
+
+267
+00:24:20,620 --> 00:24:22,040
+نقم نقم نقم نقم نقم نقم نقم نقم نقم نقم نقم نقم
+
+268
+00:24:22,040 --> 00:24:29,300
+نقم نقم نمشارعات محيطات محيطات محيطات محيطات
+
+269
+00:24:29,300 --> 00:24:29,440
+محيطات محيطات محيطات محيطات محيطات محيطات محيطات
+
+270
+00:24:29,440 --> 00:24:31,640
+محيطات محيطات محيطات محيطات محيطات محيطات محيطات
+
+271
+00:24:31,640 --> 00:24:32,140
+محيطات محيطات محيطات محيطات محيطات محيطات محيطات
+
+272
+00:24:32,140 --> 00:24:33,400
+محيطات محيطات محيطات محيطات محيطات محيطات محيطات
+
+273
+00:24:33,400 --> 00:24:33,680
+محيطات محيطات محيطات محيطات محيطات محيطات محيطات
+
+274
+00:24:33,680 --> 00:24:49,540
+محيطات محيطات محيطات محيطات محيط
+
+275
+00:24:49,570 --> 00:24:54,250
+I bought look now let's talk about non count nouns
+
+276
+00:24:54,250 --> 00:25:00,770
+non count nouns who can readyes please I bought
+
+277
+00:25:00,770 --> 00:25:03,750
+some chairs, tables and desks in other words I
+
+278
+00:25:03,750 --> 00:25:06,370
+bought some furniture good thank you now can you
+
+279
+00:25:06,370 --> 00:25:10,470
+tell me about the count and non count nouns where
+
+280
+00:25:10,470 --> 00:25:15,750
+are the count nouns count chairs, tables, desks
+
+281
+00:25:15,750 --> 00:25:19,630
+but the non count furniture okay thank you now
+
+282
+00:25:19,630 --> 00:25:24,130
+when I say furniture okay furniture it refers to
+
+283
+00:25:24,130 --> 00:25:24,370
+what
+
+284
+00:25:27,310 --> 00:25:32,450
+it refers to chairs, tables and this so it is a it
+
+285
+00:25:32,450 --> 00:25:35,630
+refers to hole that is made up of different parts
+
+286
+00:25:35,630 --> 00:25:39,890
+okay it is made up this is this is what furniture
+
+287
+00:25:39,890 --> 00:25:43,390
+this is furniture furniture so it refers to
+
+288
+00:25:43,390 --> 00:25:47,380
+different parts it's a holerefers to a whole but
+
+289
+00:25:47,380 --> 00:25:51,080
+made of different parts furniture represents a
+
+290
+00:25:51,080 --> 00:25:53,940
+whole group of things that is made up of similar
+
+291
+00:25:53,940 --> 00:25:58,240
+but separate items this is a chair this is a table
+
+292
+00:25:58,240 --> 00:26:04,320
+and and and and okay they are separate itemsyes
+
+293
+00:26:04,320 --> 00:26:08,740
+read please read the example I put I put some
+
+294
+00:26:08,740 --> 00:26:11,740
+sugar in my coffee thank you I have two nouns
+
+295
+00:26:11,740 --> 00:26:16,280
+sugar and coffee okay yes what about these nouns
+
+296
+00:26:16,280 --> 00:26:23,100
+ياسمين non countable okay non countable now read
+
+297
+00:26:23,100 --> 00:26:27,240
+سوها sugar and coffee represent four measures made
+
+298
+00:26:27,240 --> 00:26:33,170
+up of individualالجمعات او الواحدات حسنًا الآن
+
+299
+00:26:33,170 --> 00:26:37,450
+عندما أقول السحر أقصد السحر بشكل عام إنه مصنع من
+
+300
+00:26:37,450 --> 00:26:41,150
+جمعات صغيرة جدًا حسنًا عندما أقول القهوة القهوة
+
+301
+00:26:41,150 --> 00:26:45,990
+بشكل عام هذا مرة أخرى أنا أتحدث عن ما؟ نون لا يعدد
+
+302
+00:26:45,990 --> 00:26:53,590
+نون كيف يمكنني أن أدرس ماذا؟ اتجارة مختلفة بطريقات
+
+303
+00:26:53,590 --> 00:26:57,670
+أخرى قالنا أننا تحدثنا عن القهوة قبل بعض الوقت
+
+304
+00:26:57,670 --> 00:27:04,020
+قالنا أنwe can use the non-count nouns as count
+
+305
+00:27:04,020 --> 00:27:09,160
+nouns and we can say give me three coffees please
+
+306
+00:27:09,160 --> 00:27:13,000
+but there is another way also of expressing the
+
+307
+00:27:13,000 --> 00:27:20,950
+singular waterGive me a cup of water. Give me a
+
+308
+00:27:20,950 --> 00:27:25,970
+glass of water. A bottle of juice for example. So
+
+309
+00:27:25,970 --> 00:27:32,110
+again furniture it is a non-count noun. How can I
+
+310
+00:27:32,110 --> 00:27:36,290
+express again a particular quantity, a small
+
+311
+00:27:36,290 --> 00:27:36,910
+quantity
+
+312
+00:27:56,060 --> 00:27:58,820
+أسمع أسمع أسمع
+
+313
+00:28:05,220 --> 00:28:11,320
+Spoon full of okay sugar thank you next one yeah
+
+314
+00:28:11,320 --> 00:28:17,880
+water a glass of water شايمة a cup of coffee thank
+
+315
+00:28:17,880 --> 00:28:22,280
+you yes please next yeah quart of milk what about
+
+316
+00:28:22,280 --> 00:28:29,400
+bread a loaf of bread thank you and what about
+
+317
+00:28:29,400 --> 00:28:29,980
+rice
+
+318
+00:28:39,280 --> 00:28:53,220
+عشان عشان عشان عشان عشان عشان عشان
+
+319
+00:28:53,220 --> 00:28:59,500
+عشان
+
+320
+00:28:59,500 --> 00:29:07,140
+عشان عشانa piece of paper and jewelry okay good I
+
+321
+00:29:07,140 --> 00:29:12,160
+wish you luck I wish you luck where is the noun
+
+322
+00:29:12,160 --> 00:29:20,320
+luck okay luck what type of noun is luck okay
+
+323
+00:29:20,320 --> 00:29:24,120
+uncount and abstract very good last time we talked
+
+324
+00:29:24,120 --> 00:29:27,240
+about that right it is an abstract noun
+
+325
+00:29:30,190 --> 00:29:34,430
+الحظة هي فكرة عبارة عن مجلد عبارة عن مجلة عبارة عن
+
+326
+00:29:34,430 --> 00:29:36,370
+مجلة عبارة عن مجلة عبارة عن مجلة عبارة عن مجلة
+
+327
+00:29:36,370 --> 00:29:47,610
+عبارة عن مجلة عبارة عن مجلة
+
+328
+00:29:50,650 --> 00:29:55,470
+Can you see? So again it has no physical form, you
+
+329
+00:29:55,470 --> 00:29:58,210
+cannot touch it and we called it last time what?
+
+330
+00:29:58,690 --> 00:30:02,850
+An abstract noun Okay read the other example
+
+331
+00:30:02,850 --> 00:30:07,110
+please Sunshine Thank
+
+332
+00:30:07,110 --> 00:30:13,170
+you Now this is what? Phenomenon Is it singular or
+
+333
+00:30:13,170 --> 00:30:16,870
+plural? Singular How can we make it plural?
+
+334
+00:30:17,550 --> 00:30:23,360
+Phenomena Phenomena, very goodthat's right now a
+
+335
+00:30:23,360 --> 00:30:30,080
+phenomenon of what nature it is sunshine okay such
+
+336
+00:30:30,080 --> 00:30:34,920
+as sunshine is frequently used as what so again
+
+337
+00:30:34,920 --> 00:30:41,320
+this is a phenomenon used as what non count now
+
+338
+00:30:41,320 --> 00:30:47,140
+non count look in this sentence an has brown hair
+
+339
+00:30:48,600 --> 00:30:53,340
+has brown hair in this sentence this noun hair is
+
+340
+00:30:53,340 --> 00:30:57,300
+it count or non count non count very good thank
+
+341
+00:30:57,300 --> 00:31:02,380
+you now Tom has a hair on his jacket a hair on my
+
+342
+00:31:02,380 --> 00:31:08,400
+jacket count so some nouns can be used some nouns
+
+343
+00:31:08,400 --> 00:31:13,900
+can be used as count or non count good yes I
+
+344
+00:31:13,900 --> 00:31:23,610
+opened read please readتقولت in some light okay it
+
+345
+00:31:23,610 --> 00:31:27,870
+was dark دم light in this sentence is count or non
+
+346
+00:31:27,870 --> 00:31:31,370
+count okay look at this light how many lights are
+
+347
+00:31:31,370 --> 00:31:34,930
+there in this room one light two lights three four
+
+348
+00:31:34,930 --> 00:31:41,590
+ten okay sodon't okay where is it yes read this
+
+349
+00:31:41,590 --> 00:31:44,390
+sentence don't forget to turn off the light before
+
+350
+00:31:44,390 --> 00:31:47,030
+you go to bed okay light in this sentence is it
+
+351
+00:31:47,030 --> 00:31:52,250
+count or non count again some count some nouns can
+
+352
+00:31:52,250 --> 00:31:58,230
+be used as what count or non counts now some
+
+353
+00:31:58,230 --> 00:32:04,930
+common non count nouns I think it's time to stop
+
+354
+00:32:04,930 --> 00:32:09,490
+okayI don't want to keep you late thank you very
+
+355
+00:32:09,490 --> 00:32:13,010
+much but please complete the exercises complete
+
+356
+00:32:13,010 --> 00:32:15,470
+the other parts of the exercises at home
+
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/3csAdG_Imio_raw.json b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/3csAdG_Imio_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..43ae3331a8c46142d40b9a37dc60c654d826a932
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/3csAdG_Imio_raw.json
@@ -0,0 +1 @@
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now look at this sentence Alan and Lisa", "tokens": [2346, 294, 19938, 294, 19938, 8717, 13063, 264, 700, 8174, 9122, 2655, 16758, 29739, 29399, 665, 9122, 2655, 16758, 29739, 29399, 293, 264, 661, 472, 9122, 2655, 16758, 29739, 8315, 2655, 588, 665, 300, 311, 558, 1392, 309, 307, 472, 1446, 457, 341, 307, 20010, 293, 341, 307, 437, 25377, 588, 665, 1309, 291, 588, 709, 665, 586, 574, 412, 341, 8174, 16442, 293, 12252], "avg_logprob": -0.2160274643789638, "compression_ratio": 1.6685393258426966, "no_speech_prob": 0.0, "words": [{"start": 380.43, "end": 380.73, "word": "yes", "probability": 0.0777587890625}, {"start": 380.73, "end": 381.03, "word": " in", "probability": 0.73876953125}, {"start": 381.03, "end": 381.49, "word": " Arabic", "probability": 0.859375}, {"start": 381.49, "end": 381.99, "word": " in", "probability": 0.27001953125}, {"start": 381.99, "end": 382.35, "word": " Arabic", "probability": 0.921875}, {"start": 382.35, "end": 382.71, "word": " نور", "probability": 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Ali's house this bag is for Khadija and Dua", "tokens": [11176, 1782, 307, 337, 16948, 4775, 293, 12020, 321, 584, 309, 307, 16948, 4775, 293, 12020, 311, 1782, 1392, 309, 307, 16948, 4775, 293, 12020, 311, 1782, 341, 3411, 307, 337, 11681, 345, 20642, 293, 413, 4398], "avg_logprob": -0.1792763177501528, "compression_ratio": 1.6962025316455696, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 410.87, "end": 411.21, "word": "this", "probability": 0.50146484375}, {"start": 411.21, "end": 411.69, "word": " house", "probability": 0.90087890625}, {"start": 411.69, "end": 412.03, "word": " is", "probability": 0.96728515625}, {"start": 412.03, "end": 412.41, "word": " for", "probability": 0.9775390625}, {"start": 412.41, "end": 412.93, "word": " Fatima", "probability": 0.78857421875}, {"start": 412.93, "end": 413.21, "word": " and", "probability": 0.96533203125}, {"start": 413.21, "end": 413.49, "word": " Ali", "probability": 0.6943359375}, {"start": 413.49, "end": 414.39, "word": 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By and, good Now this is an exercise, I'll give you three minutes to do this exercise, exercise eight, please look at your box and do the exercise", "tokens": [8297, 11, 370, 321, 909, 264, 19484, 27194, 262, 322, 264, 2572, 23307, 498, 436, 366, 6869, 420, 436, 366, 4582, 538, 437, 30, 3146, 293, 11, 665, 823, 341, 307, 364, 5380, 11, 286, 603, 976, 291, 1045, 2077, 281, 360, 341, 5380, 11, 5380, 3180, 11, 1767, 574, 412, 428, 2424, 293, 360, 264, 5380], "avg_logprob": -0.2296605629139933, "compression_ratio": 1.5246913580246915, "no_speech_prob": 0.0, "words": [{"start": 446.93, "end": 447.31, "word": "Okay,", "probability": 0.72509765625}, {"start": 447.41, "end": 447.61, "word": " so", "probability": 0.81005859375}, {"start": 447.61, "end": 447.83, "word": " we", "probability": 0.9228515625}, {"start": 447.83, "end": 448.13, "word": " add", "probability": 0.8798828125}, {"start": 448.13, "end": 448.29, "word": " the", "probability": 0.71142578125}, {"start": 448.29, "end": 448.85, 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This is a common mistake. A lot of students think since we begin with two, we should add S. 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other sentence yes please read it again read it again she has a five-year-old very good thank you very much okay and this again this is what", "tokens": [10721, 2655, 2407, 1975, 2407, 9640, 6055, 995, 14851, 1975, 2655, 2407, 1975, 2407, 9640, 6055, 995, 14851, 309, 1072, 11221, 264, 23307, 574, 412, 264, 661, 8174, 2086, 1767, 1401, 309, 797, 1401, 309, 797, 750, 575, 257, 1732, 12, 5294, 12, 2641, 588, 665, 1309, 291, 588, 709, 1392, 293, 341, 797, 341, 307, 437], "avg_logprob": -0.30603448686928586, "compression_ratio": 1.4866666666666666, "no_speech_prob": 0.0, "words": [{"start": 836.75, "end": 837.37, "word": "أتو", "probability": 0.5241495768229166}, {"start": 837.37, "end": 837.89, "word": " اوار", "probability": 0.535400390625}, {"start": 837.89, "end": 838.33, "word": " تاست", "probability": 0.6759033203125}, {"start": 838.33, "end": 839.09, "word": " اتو", "probability": 0.75}, {"start": 839.09, "end": 839.87, "word": " اوار", "probability": 0.9265950520833334}, {"start": 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"seek": 88937, "start": 862.63, "end": 889.37, "text": "we use a hyphen when we use a noun a modifier to describe the noun it should be hyphenated we use hyphens and again remember to use what the singular never use the plural okay yes read please this note when a noun used as a modifier is combined with a number expression the noun is singular and plural", "tokens": [826, 764, 257, 2477, 47059, 562, 321, 764, 257, 23307, 257, 38011, 281, 6786, 264, 23307, 309, 820, 312, 2477, 47059, 770, 321, 764, 2477, 950, 694, 293, 797, 1604, 281, 764, 437, 264, 20010, 1128, 764, 264, 25377, 1392, 2086, 1401, 1767, 341, 3637, 562, 257, 23307, 1143, 382, 257, 38011, 307, 9354, 365, 257, 1230, 6114, 264, 23307, 307, 20010, 293, 25377], "avg_logprob": -0.22956730769230768, "compression_ratio": 1.8353658536585367, "no_speech_prob": 0.0, "words": [{"start": 862.63, "end": 863.03, "word": "we", "probability": 0.03997802734375}, {"start": 863.03, "end": 864.47, "word": " use", "probability": 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Thank you. Now how many bags do you have? How many bags do you have دعا? How many bags do you have? One bag okay. 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Now what about the non-count nouns؟ I say some furniture. 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So again it has no physical form, you cannot touch it and we called it last time what? An abstract noun Okay read the other example please Sunshine Thank you Now this is what? Phenomenon Is it singular or plural? Singular How can we make it plural? 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diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/4pb6UpWvYds_raw.json b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/4pb6UpWvYds_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..47e479bb46cdb0b0955a7334142aed07de858757
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/4pb6UpWvYds_raw.json
@@ -0,0 +1 @@
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Good. Next one, come please clean then write yes, read your answers, talk while you are writing", "tokens": [51, 1641, 77, 74, 291, 13, 2205, 13, 3087, 472, 11, 808, 1767, 2541, 550, 2464, 2086, 11, 1401, 428, 6338, 11, 751, 1339, 291, 366, 3579], "avg_logprob": -0.42578126383679255, "compression_ratio": 1.1521739130434783, "no_speech_prob": 0.0, "words": [{"start": 1411.47, "end": 1411.83, "word": "Thank", "probability": 0.647308349609375}, {"start": 1411.83, "end": 1412.07, "word": " you.", "probability": 0.95458984375}, {"start": 1412.21, "end": 1412.47, "word": " Good.", "probability": 0.66259765625}, {"start": 1412.71, "end": 1412.95, "word": " Next", "probability": 0.77734375}, {"start": 1412.95, "end": 1413.33, "word": " one,", "probability": 0.953125}, {"start": 1413.41, "end": 1413.61, "word": " come", "probability": 0.87841796875}, {"start": 1413.61, "end": 1414.25, "word": " please", "probability": 0.77734375}, {"start": 1414.25, "end": 1423.79, "word": " clean", "probability": 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A little and little are used with non count nouns. What's the difference between few and a few?", "tokens": [13267, 257, 1326, 293, 257, 1326, 366, 1143, 365, 1207, 48184, 13, 316, 707, 293, 707, 366, 1143, 365, 2107, 1207, 48184, 13, 708, 311, 264, 2649, 1296, 1326, 293, 257, 1326, 30], "avg_logprob": -0.28170956495930166, "compression_ratio": 1.5434782608695652, "no_speech_prob": 0.0, "words": [{"start": 1770.4800000000002, "end": 1771.3200000000002, "word": "Now", "probability": 0.0672607421875}, {"start": 1771.3200000000002, "end": 1772.16, "word": " a", "probability": 0.56103515625}, {"start": 1772.16, "end": 1772.56, "word": " few", "probability": 0.93408203125}, {"start": 1772.56, "end": 1773.0, "word": " and", "probability": 0.958984375}, {"start": 1773.0, "end": 1773.14, "word": " a", "probability": 0.82373046875}, {"start": 1773.14, "end": 1773.42, "word": " few", "probability": 0.9462890625}, {"start": 1773.42, "end": 1774.06, "word": " are", "probability": 0.955078125}, {"start": 1774.06, "end": 1774.44, "word": " used", 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listened to a little music", "tokens": [75, 703, 293, 257, 707, 586, 321, 458, 300, 1326, 293, 257, 1326, 1143, 337, 1207, 707, 293, 257, 707, 366, 1143, 337, 2107, 1207, 586, 382, 291, 536, 321, 9980, 257, 1326, 5781, 321, 13207, 281, 257, 707, 1318], "avg_logprob": -0.234375, "compression_ratio": 1.73, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1785.95, "end": 1786.57, "word": "little", "probability": 0.70166015625}, {"start": 1786.57, "end": 1786.93, "word": " and", "probability": 0.873046875}, {"start": 1786.93, "end": 1787.07, "word": " a", "probability": 0.8984375}, {"start": 1787.07, "end": 1787.37, "word": " little", "probability": 0.87060546875}, {"start": 1787.37, "end": 1788.27, "word": " now", "probability": 0.051849365234375}, {"start": 1788.27, "end": 1788.53, "word": " we", "probability": 0.8662109375}, {"start": 1788.53, "end": 1788.81, "word": " know", "probability": 0.90283203125}, {"start": 1788.81, "end": 1789.17, "word": " that", "probability": 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{"id": 68, "seek": 191361, "start": 1903.67, "end": 1913.61, "text": "considering that this used with count and this is used with non count now if I say I have little petrol in my car", "tokens": [21190, 1438, 278, 300, 341, 1143, 365, 1207, 293, 341, 307, 1143, 365, 2107, 1207, 586, 498, 286, 584, 286, 362, 707, 32377, 294, 452, 1032], "avg_logprob": -0.20978008928122344, "compression_ratio": 1.3452380952380953, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 1903.67, "end": 1904.41, "word": "considering", "probability": 0.70166015625}, {"start": 1904.41, "end": 1904.77, "word": " that", "probability": 0.89404296875}, {"start": 1904.77, "end": 1905.15, "word": " this", "probability": 0.89990234375}, {"start": 1905.15, "end": 1905.47, "word": " used", "probability": 0.63671875}, {"start": 1905.47, "end": 1905.69, "word": " with", "probability": 0.9169921875}, {"start": 1905.69, "end": 1906.11, "word": " count", "probability": 0.9345703125}, {"start": 1906.11, "end": 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So, but if I have a few, if I have a little, sorry, I can go to my house, it can take me to my house Can you give me some other examples like that? 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you good next one yes please", "tokens": [8297, 1230, 2309, 2086, 1767, 456, 366, 1326, 8815, 4268, 1309, 291, 1230, 3407, 2086, 1767, 1392, 1309, 291, 665, 958, 472, 2086, 1767], "avg_logprob": -0.30312500953674315, "compression_ratio": 1.488888888888889, "no_speech_prob": 0.0, "words": [{"start": 2282.34, "end": 2282.68, "word": "Okay", "probability": 0.3095703125}, {"start": 2282.68, "end": 2282.94, "word": " number", "probability": 0.75146484375}, {"start": 2282.94, "end": 2283.5, "word": " six", "probability": 0.7255859375}, {"start": 2283.5, "end": 2284.92, "word": " yes", "probability": 0.266845703125}, {"start": 2284.92, "end": 2285.46, "word": " please", "probability": 0.82177734375}, {"start": 2285.46, "end": 2288.38, "word": " there", "probability": 0.170166015625}, {"start": 2288.38, "end": 2291.98, "word": " are", "probability": 0.96337890625}, {"start": 2291.98, "end": 2293.66, "word": " few", "probability": 0.7099609375}, {"start": 2293.66, "end": 2294.4, "word": " 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\ No newline at end of file
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/4pb6UpWvYds_raw.srt b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/4pb6UpWvYds_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..dfa4226f6dd67bd255081191b95be07f55c05910
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/4pb6UpWvYds_raw.srt
@@ -0,0 +1,1456 @@
+1
+00:00:21,190 --> 00:00:27,450
+أهلا بكم جميعًا كيف حالت؟ هل استمتعت من السفر؟ أنا
+
+2
+00:00:27,450 --> 00:00:34,830
+بخير شكرا لك لماذا لا؟ لماذا
+
+3
+00:00:34,830 --> 00:00:39,830
+لا؟ لذا لا يمكنك أن تقول الحمد لله توقف عن
+
+4
+00:00:39,830 --> 00:00:43,550
+الانفعال، توقف عن الانفعال يجب أن تقول دائما الحمد
+
+5
+00:00:43,550 --> 00:00:49,230
+لله حسنا الأن
+
+6
+00:00:51,970 --> 00:00:57,330
+we are still talking about nouns you know nouns
+
+7
+00:00:57,330 --> 00:01:02,470
+can be used with some expressions of a quantity
+
+8
+00:01:02,470 --> 00:01:08,670
+and nouns are different as you know we have some
+
+9
+00:01:08,670 --> 00:01:14,370
+singular nouns singular plural count plural count
+
+10
+00:01:14,370 --> 00:01:20,890
+and we have non countHow can we use these nouns
+
+11
+00:01:20,890 --> 00:01:24,150
+with the expressions of a quantity؟ Some
+
+12
+00:01:24,150 --> 00:01:30,490
+expressions
+
+13
+00:01:30,490 --> 00:01:35,090
+can be used only with singular count nouns, others
+
+14
+00:01:35,090 --> 00:01:39,370
+can be used with plural, others can be used with
+
+15
+00:01:39,370 --> 00:01:46,460
+non-count nounsothers may be used with more than
+
+16
+00:01:46,460 --> 00:01:51,280
+one type of nouns now let's see if you look at
+
+17
+00:01:51,280 --> 00:01:56,260
+these expressions now apple this is what what type
+
+18
+00:01:56,260 --> 00:02:00,940
+of noun is it singular count apple book okay
+
+19
+00:02:00,940 --> 00:02:08,390
+student we can say one apple twoOkay sorry each
+
+20
+00:02:08,390 --> 00:02:14,310
+apple every apple so now one each and every are
+
+21
+00:02:14,310 --> 00:02:19,310
+used with what type of nouns singular count nouns
+
+22
+00:02:19,310 --> 00:02:22,390
+thank you very much and you know singular count
+
+23
+00:02:22,390 --> 00:02:26,490
+nouns can be made plural by adding what is or is
+
+24
+00:02:26,490 --> 00:02:30,630
+since we can say one apple we can say what two
+
+25
+00:02:30,630 --> 00:02:35,670
+apples three apples and so onwe can also say what?
+
+26
+00:02:36,030 --> 00:02:40,290
+both apples, both students and so on and we can
+
+27
+00:02:40,290 --> 00:02:47,440
+say a couple of apples we can say what? yesa few
+
+28
+00:02:47,440 --> 00:02:54,920
+of apples thank you we can say several apples
+
+29
+00:02:54,920 --> 00:02:58,600
+thank you and we can say many apples and we can
+
+30
+00:02:58,600 --> 00:03:03,780
+say what a number of apples now these expressions
+
+31
+00:03:03,780 --> 00:03:08,240
+of a quantity one each every two and and okay are
+
+32
+00:03:08,240 --> 00:03:14,090
+always used with whatwith singular count nouns
+
+33
+00:03:14,090 --> 00:03:17,070
+that's the first group and the other group is used
+
+34
+00:03:17,070 --> 00:03:21,850
+with what plural so they are used with count nouns
+
+35
+00:03:21,850 --> 00:03:25,170
+in general some with singular and other with
+
+36
+00:03:25,170 --> 00:03:29,490
+plural can i use them with non count nouns no they
+
+37
+00:03:29,490 --> 00:03:33,410
+cannot be used with non count nouns this is the
+
+38
+00:03:33,410 --> 00:03:40,520
+first group look at the other group a littlemuch a
+
+39
+00:03:40,520 --> 00:03:44,200
+great deal of look at rice what type of noun is
+
+40
+00:03:44,200 --> 00:03:50,180
+rice please speak one speaker yeah it is a non
+
+41
+00:03:50,180 --> 00:03:54,480
+count noun thank you it is a non count so we say
+
+42
+00:03:54,480 --> 00:04:02,440
+what a little rice okay we say much and we saya
+
+43
+00:04:02,440 --> 00:04:06,720
+great deal of now we have another three
+
+44
+00:04:06,720 --> 00:04:11,400
+expressions what are they؟ yes مريدا a little,
+
+45
+00:04:11,600 --> 00:04:15,880
+much, a great, a great deal of they are used with
+
+46
+00:04:15,880 --> 00:04:19,460
+what type of nouns؟ yes who was asking there? any
+
+47
+00:04:19,460 --> 00:04:25,340
+question? who's asking? no questions okay now this
+
+48
+00:04:25,340 --> 00:04:28,940
+new or this new group of expressions is used with
+
+49
+00:04:28,940 --> 00:04:33,580
+what؟non count nouns now look at these expressions
+
+50
+00:04:33,580 --> 00:04:39,000
+now no apples and no rice what does that mean
+
+51
+00:04:39,000 --> 00:04:46,180
+thank you they can be used with count with non
+
+52
+00:04:46,180 --> 00:04:51,560
+count nouns okay now hardly any can be used yes
+
+53
+00:04:51,560 --> 00:04:56,340
+hardly any apples and hardly any what rice yes
+
+54
+00:04:56,340 --> 00:04:57,640
+please read the other one
+
+55
+00:05:04,410 --> 00:05:07,910
+Thank you you know the difference between some and
+
+56
+00:05:07,910 --> 00:05:13,990
+any okay now I have some apples I have some money
+
+57
+00:05:13,990 --> 00:05:21,170
+I have some pens okay but have you got any any
+
+58
+00:05:21,170 --> 00:05:28,190
+money for example or I haven't got any foodso some
+
+59
+00:05:28,190 --> 00:05:34,330
+yes خديجة positive okay yes thank you affirmative
+
+60
+00:05:34,330 --> 00:05:39,350
+yeah questions and negative you are right thank
+
+61
+00:05:39,350 --> 00:05:45,690
+you good now a lot of and lots a lot of and lots
+
+62
+00:05:45,690 --> 00:05:52,230
+they are used with yeswith count and non count you
+
+63
+00:05:52,230 --> 00:05:56,290
+can say a lot of or lots of what apples and lots
+
+64
+00:05:56,290 --> 00:06:03,850
+of thank you yes please next one plenty of thank
+
+65
+00:06:03,850 --> 00:06:08,390
+you so this is also used with what count and non
+
+66
+00:06:08,390 --> 00:06:11,770
+count nouns and what about most yes sahar
+
+67
+00:06:14,590 --> 00:06:20,710
+مصدرات مصدرات مصدرات مصدرات مصدرات
+
+68
+00:06:20,710 --> 00:06:27,710
+مصدرات مصدرات
+
+69
+00:06:27,710 --> 00:06:34,310
+مصدرات مصدرات مصدرات مصدرات مصدرات مصدرات
+
+70
+00:06:34,310 --> 00:06:38,630
+مصدرات
+
+71
+00:06:41,030 --> 00:06:44,850
+Okay what is the first group who can read it again
+
+72
+00:06:44,850 --> 00:06:48,950
+yes please okay
+
+73
+00:06:48,950 --> 00:06:57,710
+this is singular count okay thank you go on okay
+
+74
+00:06:57,710 --> 00:07:03,790
+they are used with plural okay count thank you and
+
+75
+00:07:03,790 --> 00:07:08,340
+the other group yes khadijaa little much a great
+
+76
+00:07:08,340 --> 00:07:11,260
+deal of it used with non count nouns they are used
+
+77
+00:07:11,260 --> 00:07:15,560
+only with non count nouns thank you and the third
+
+78
+00:07:15,560 --> 00:07:16,480
+group دعاء
+
+79
+00:07:25,160 --> 00:07:28,740
+okay thank you can be used with count and with non
+
+80
+00:07:28,740 --> 00:07:31,980
+count nouns now look at this exercise look at your
+
+81
+00:07:31,980 --> 00:07:35,020
+books you have the exercise in the book draw a
+
+82
+00:07:35,020 --> 00:07:37,640
+line through the expressions that cannot be used
+
+83
+00:07:37,640 --> 00:07:45,960
+to complete the sentences draw a line yes
+
+84
+00:07:45,960 --> 00:07:52,680
+pleaseالان أولاً هذا هو ماذا؟ عمل في المنزل، هل هو
+
+85
+00:07:52,680 --> 00:07:55,920
+count او non-count؟ نون، نون، نون، نون، نون، نون،
+
+86
+00:07:55,920 --> 00:07:57,000
+نون، نون، نون، نون، نون، نون، نون، نون، نون، نون،
+
+87
+00:07:57,000 --> 00:07:59,280
+نون، نون، نون، نون، نون، نون، نون، نون، نون، نون،
+
+88
+00:07:59,280 --> 00:08:01,180
+نون، نون، نون، نون، نون، نون، نون، نون، نون، نون،
+
+89
+00:08:01,180 --> 00:08:03,360
+نون، نون، نون، نون، نون، نون، نون، نون، نون، نون،
+
+90
+00:08:03,360 --> 00:08:04,160
+نون، نون، نون، نون، نون، نون، نون، نون، نون، نون،
+
+91
+00:08:04,160 --> 00:08:10,200
+نون، نون، نون، نون، نون، نون، نون، نون، نون
+
+92
+00:08:42,330 --> 00:08:45,770
+yes tell me what shall where shall we draw the
+
+93
+00:08:45,770 --> 00:08:49,170
+line where shall we draw the line yes please
+
+94
+00:08:49,170 --> 00:09:05,550
+number three number one okay yes
+
+95
+00:09:05,550 --> 00:09:12,510
+that cannot be used okay so number oneand okay
+
+96
+00:09:12,510 --> 00:09:16,410
+number one good number six number six too many
+
+97
+00:09:16,410 --> 00:09:22,250
+okay number nine okay number nine you are right
+
+98
+00:09:22,250 --> 00:09:26,610
+thank you a number of good thank you a grade what
+
+99
+00:09:26,610 --> 00:09:29,950
+is a few you are right this is used with count
+
+100
+00:09:29,950 --> 00:09:37,230
+nouns thank you what about twoseveral with count
+
+101
+00:09:37,230 --> 00:09:39,850
+nouns yes used with count nouns you are right
+
+102
+00:09:39,850 --> 00:09:44,670
+several homework okay now what about the others
+
+103
+00:09:44,670 --> 00:09:48,810
+hardly
+
+104
+00:09:48,810 --> 00:09:56,210
+any sorry I can't get you hardly any yes can be
+
+105
+00:09:56,210 --> 00:09:59,210
+used which one I know it can be used for nine
+
+106
+00:09:59,210 --> 00:10:01,810
+count but I mean here it can't be used you said
+
+107
+00:10:01,810 --> 00:10:05,160
+that any of them negative and positive rightno no
+
+108
+00:10:05,160 --> 00:10:08,320
+no hardly any even if it is negative or positive
+
+109
+00:10:08,320 --> 00:10:14,620
+it can be used okay huda has okay it can be
+
+110
+00:10:14,620 --> 00:10:23,300
+grammatically it is accepted yeah has no
+
+111
+00:10:23,300 --> 00:10:28,980
+homework can be used for plural count and for a
+
+112
+00:10:28,980 --> 00:10:33,420
+non count what about the others what about the
+
+113
+00:10:33,420 --> 00:10:42,780
+othersyes please too much okay should be deleted
+
+114
+00:10:42,780 --> 00:10:52,400
+cannot be used good too much a little okay what
+
+115
+00:10:52,400 --> 00:11:00,520
+else okay a great deal of thank you and some
+
+116
+00:11:09,430 --> 00:11:14,690
+تحقق إجابتك الآن
+
+117
+00:11:14,690 --> 00:11:21,650
+انظر
+
+118
+00:11:21,650 --> 00:11:26,560
+إلى التجارب الأخرىthe sentences with much or many
+
+119
+00:11:26,560 --> 00:11:31,080
+look much or money money what what shall we use
+
+120
+00:11:31,080 --> 00:11:35,220
+look two words only also write the plural form of
+
+121
+00:11:35,220 --> 00:11:38,820
+the nouns as necessary in some sentences you will
+
+122
+00:11:38,820 --> 00:11:42,920
+need to choose the correct okay verb sometimes we
+
+123
+00:11:42,920 --> 00:11:50,300
+need to change the verb yeah number one yes
+
+124
+00:11:50,300 --> 00:11:55,320
+number three here I haven't فضلي go onmuch mail
+
+125
+00:11:55,320 --> 00:12:03,920
+thank you number four
+
+126
+00:12:03,920 --> 00:12:10,020
+فضلي go on I don't get many letters I don't get
+
+127
+00:12:10,020 --> 00:12:18,640
+many letters thank you so I don't get yes
+
+128
+00:12:18,640 --> 00:12:27,240
+please there is too much furniturethere is
+
+129
+00:12:27,240 --> 00:12:36,400
+too much okay there is too
+
+130
+00:12:36,400 --> 00:12:45,080
+much good thank you this is what this is number
+
+131
+00:12:45,080 --> 00:12:46,580
+five okay
+
+132
+00:12:49,190 --> 00:12:51,530
+who is the speaker who is the speaker what's on
+
+133
+00:12:51,530 --> 00:12:54,870
+delete
+
+134
+00:12:54,870 --> 00:13:00,790
+what this
+
+135
+00:13:00,790 --> 00:13:12,170
+one okay there like that there is too much okay
+
+136
+00:13:12,170 --> 00:13:17,210
+next one yes
+
+137
+00:13:18,520 --> 00:13:26,100
+هل تريد أن تسأل ؟ إجابة ماتت لأنها
+
+138
+00:13:26,100 --> 00:13:30,380
+استخدمة استخدمتها هنا استخدمتها يمكنك تخلصها أو
+
+139
+00:13:30,380 --> 00:13:35,920
+تبقى هل أسألنا أن نخلصها؟ لا فقط استخدمتها
+
+140
+00:13:35,920 --> 00:13:40,600
+استخدمتها كثير أو كثير؟ منذ أن كنت تكتبتها هذا هو
+
+141
+00:13:40,600 --> 00:13:46,820
+الإجابة وهذه التجارب هي التي تعتبرها حتى و إذا
+
+142
+00:13:46,820 --> 00:13:53,890
+اختلصت أو كتبتهناك مصدر .. حسناً هناك مصدر أنت محق
+
+143
+00:13:53,890 --> 00:13:58,250
+إنه يجب أن يتم إخفاءه لأنه سيكون مراجعة حسناً؟
+
+144
+00:13:58,250 --> 00:14:02,230
+سيكون مراجعة .. مراجعة .. مراجعة .. مراجعة ..
+
+145
+00:14:02,230 --> 00:14:02,450
+مراجعة .. مراجعة .. مراجعة .. مراجعة .. مراجعة ..
+
+146
+00:14:02,450 --> 00:14:02,550
+مراجعة .. مراجعة .. مراجعة .. مراجعة .. مراجعة ..
+
+147
+00:14:02,550 --> 00:14:04,130
+مراجعة .. مراجعة .. مراجعة .. مراجعة .. مراجعة ..
+
+148
+00:14:04,130 --> 00:14:04,250
+مراجعة .. مراجعة .. مراجعة .. مراجعة .. مراجعة ..
+
+149
+00:14:04,250 --> 00:14:09,670
+مراجعة .. مراجعة .. مراجعة .. مراجعة .. مراجعة ..
+
+150
+00:14:09,670 --> 00:14:16,390
+مراجعة .. مراجعة .. مراجعة .. مراجعة .. مراجعة
+
+151
+00:14:16,390 --> 00:14:20,430
+..I can't go with you because I have too much work
+
+152
+00:14:20,430 --> 00:14:27,970
+I can't go with you because I have too much okay
+
+153
+00:14:27,970 --> 00:14:37,510
+thank you good I have too much okay yes please
+
+154
+00:14:37,510 --> 00:14:42,830
+come please and write it it is easier for you to
+
+155
+00:14:42,830 --> 00:14:45,510
+write come please and write it
+
+156
+00:14:48,480 --> 00:14:57,140
+So this is number what number seven how
+
+157
+00:14:57,140 --> 00:15:05,000
+many sides right sides okay thank
+
+158
+00:15:05,000 --> 00:15:15,960
+you next one yes please thank
+
+159
+00:15:15,960 --> 00:15:16,500
+you good
+
+160
+00:15:20,820 --> 00:15:27,780
+Okay next group please come come
+
+161
+00:15:27,780 --> 00:15:39,500
+please clean and write I
+
+162
+00:15:39,500 --> 00:15:42,460
+haven't okay you cannot get it okay tell me what
+
+163
+00:15:42,460 --> 00:15:50,030
+shall I write I I haven't get I haven't metمش كثير
+
+164
+00:15:50,030 --> 00:15:55,290
+من الناس، شكرا، نعم، أرجوك
+
+165
+00:15:55,290 --> 00:16:03,210
+كم؟
+
+166
+00:16:03,210 --> 00:16:09,090
+شكرا، رقم 11، نعم، أرجوك أعتقد أن هناك كثير ..
+
+167
+00:16:09,090 --> 00:16:13,750
+كثير .. نعم،
+
+168
+00:16:13,750 --> 00:16:17,310
+أعتقد أن هناك كثير عنوان
+
+169
+00:16:23,780 --> 00:16:28,280
+yes please could
+
+170
+00:16:28,280 --> 00:16:32,060
+you
+
+171
+00:16:32,060 --> 00:16:36,520
+repeat it again please you are right come please
+
+172
+00:16:36,520 --> 00:16:44,600
+come next
+
+173
+00:16:44,600 --> 00:16:46,120
+one yes come please
+
+174
+00:17:01,920 --> 00:17:07,720
+yes فضلي come the doctor what did you write has so
+
+175
+00:17:07,720 --> 00:17:18,000
+many patients you are right thank you next one how
+
+176
+00:17:18,000 --> 00:17:18,800
+many teeth
+
+177
+00:17:27,650 --> 00:17:34,790
+أنت محق، شكرا، وأخيرًا، نعم، أرجوك،
+
+178
+00:17:34,790 --> 00:17:52,150
+أنت محق، تعالى شكرا
+
+179
+00:18:06,060 --> 00:18:10,140
+الأن، انظر إلى هذا التعليم إذا كان المصطلح يمكن أن
+
+180
+00:18:10,140 --> 00:18:15,340
+يكون استخدامه لإكمال الكلمة، اكتبها بطريقة صحيحة،
+
+181
+00:18:15,340 --> 00:18:18,960
+بمعنى عشوائي أو عشوائي، إذا كان المصطلح لا يمكن أن
+
+182
+00:18:18,960 --> 00:18:23,020
+يكون استخدامه لإكمال الكلمة، اكتب صفحة صحيحة،
+
+183
+00:18:23,020 --> 00:18:29,220
+صحيحة، صحيحة، صحيحة، صحيحة، صحيحة، صحيحة، صحيحة،
+
+184
+00:18:29,220 --> 00:18:29,220
+صحيحة، صحيحة، صحيحة، صحيحة، صحيحة، صحيحة، صحيحة،
+
+185
+00:18:29,220 --> 00:18:32,580
+صحيحة، صحيحة، صحيحة، صحيحة، صحيحة
+
+186
+00:18:37,180 --> 00:18:42,220
+Can I say several lamps? Yes Can I say several
+
+187
+00:18:42,220 --> 00:18:50,120
+furniture? No Zero article Can I .. Yes Okay
+
+188
+00:18:50,120 --> 00:18:54,560
+that's right So the first and the last are plural
+
+189
+00:18:54,560 --> 00:18:58,840
+count nouns Can be used with several Number two
+
+190
+00:18:58,840 --> 00:19:02,460
+Number two Do number two please You have thirty
+
+191
+00:19:02,460 --> 00:19:05,080
+seconds Do it in your book In your book
+
+192
+00:19:24,360 --> 00:19:25,760
+السلام عليكم و رحمه الله
+
+193
+00:19:46,640 --> 00:19:51,900
+Okay move to number three just
+
+194
+00:19:51,900 --> 00:19:52,500
+a minute
+
+195
+00:20:03,910 --> 00:20:09,810
+تأخذ 2 دقيقة و أكمل تجاربك كلها حتى 12 دقيقة هذا
+
+196
+00:20:09,810 --> 00:20:19,890
+يكفي حسنا دعونا نفعل تجارب رقم 2 نجوة رقم
+
+197
+00:20:19,890 --> 00:20:29,370
+2 حسنا افعل كلها انت لديك كتابة كتابة
+
+198
+00:20:29,370 --> 00:20:29,890
+جيدة
+
+199
+00:20:41,660 --> 00:20:45,880
+why did you write you can use write it you know if
+
+200
+00:20:45,880 --> 00:20:48,760
+the given noun can be used to complete write it in
+
+201
+00:20:48,760 --> 00:20:54,570
+the correct place so can we use riceyes we can say
+
+202
+00:20:54,570 --> 00:20:59,390
+a lot of is used with what count and non count
+
+203
+00:20:59,390 --> 00:21:03,250
+okay can be used with count and non count so write
+
+204
+00:21:03,250 --> 00:21:11,430
+it here please yes write rice and also the other
+
+205
+00:21:11,430 --> 00:21:13,590
+one you are right yes
+
+206
+00:21:22,230 --> 00:21:33,890
+rice with c with c rice with c thank
+
+207
+00:21:33,890 --> 00:21:38,110
+you
+
+208
+00:21:38,110 --> 00:21:41,610
+good thanks next one
+
+209
+00:21:50,790 --> 00:21:59,490
+Salt Yes number four come please Equipment
+
+210
+00:21:59,490 --> 00:22:07,210
+thank you Equipment
+
+211
+00:22:07,210 --> 00:22:13,490
+it is non count it is non count yes we cannot say
+
+212
+00:22:13,490 --> 00:22:15,950
+we use it like that
+
+213
+00:22:21,700 --> 00:22:39,580
+النمبر أربع .. الأن
+
+214
+00:22:39,580 --> 00:22:43,640
+إسمع .. الأن بريد .. هل هو count او non count؟
+
+215
+00:22:43,640 --> 00:22:49,860
+انها بريد ..Okay it is month count but when we
+
+216
+00:22:49,860 --> 00:22:54,220
+sell a loaf of bread this is count so this is
+
+217
+00:22:54,220 --> 00:23:01,580
+month count and okay also honey thank you yes
+
+218
+00:23:01,580 --> 00:23:02,280
+please come
+
+219
+00:23:31,470 --> 00:23:43,790
+Thank you. Good. Next one, come please clean
+
+220
+00:23:43,790 --> 00:23:55,430
+then write yes,
+
+221
+00:23:55,470 --> 00:23:57,690
+read your answers, talk while you are writing
+
+222
+00:24:08,180 --> 00:24:17,840
+Okay I bought some light bulbs بالبس okay good I
+
+223
+00:24:17,840 --> 00:24:23,400
+bought
+
+224
+00:24:23,400 --> 00:24:25,640
+some hardware hardware good
+
+225
+00:24:32,880 --> 00:24:35,660
+I bought some computer software software thank you
+
+226
+00:24:35,660 --> 00:24:37,680
+next one yes please come
+
+227
+00:25:02,840 --> 00:25:07,740
+yes plenty of is used with count and non count
+
+228
+00:25:07,740 --> 00:25:15,620
+okay sleep good
+
+229
+00:25:15,620 --> 00:25:30,160
+facts and help next one come please thank you yes
+
+230
+00:25:30,160 --> 00:25:40,620
+both is used withcount gone so women
+
+231
+00:25:40,620 --> 00:25:50,960
+movies
+
+232
+00:25:50,960 --> 00:25:56,360
+okay scenes zero article look there is a printing
+
+233
+00:25:56,360 --> 00:26:01,510
+mistake here right this should be aOkay next one
+
+234
+00:26:01,510 --> 00:26:23,450
+next one yes please come come فضليه yes read
+
+235
+00:26:23,450 --> 00:26:24,510
+while writing
+
+236
+00:26:31,560 --> 00:26:36,720
+شيرت شيرت somewhere pens and chalk okay thank you
+
+237
+00:26:36,720 --> 00:26:40,880
+yes please
+
+238
+00:26:40,880 --> 00:26:45,340
+yeah
+
+239
+00:26:45,340 --> 00:26:52,240
+okay number ten okay this is number ten clean and
+
+240
+00:26:52,240 --> 00:26:59,820
+right a great deal of used word okay go on
+
+241
+00:27:12,340 --> 00:27:22,680
+well thank you yes eleven come here please a
+
+242
+00:27:22,680 --> 00:27:34,050
+little is used with none count goodI need
+
+243
+00:27:34,050 --> 00:27:43,470
+money money advice
+
+244
+00:27:43,470 --> 00:27:47,070
+good time
+
+245
+00:27:51,420 --> 00:27:54,080
+this is cannot be used with minute you are right
+
+246
+00:27:54,080 --> 00:27:58,820
+thank you next one come please okay you next
+
+247
+00:27:58,820 --> 00:28:05,180
+ياسمين after here get ready it's the last okay so
+
+248
+00:28:05,180 --> 00:28:13,700
+next exercise many
+
+249
+00:28:13,700 --> 00:28:20,820
+with count nouns so we say many ideas yeah
+
+250
+00:28:30,550 --> 00:28:35,190
+بالـ E هناك
+
+251
+00:28:35,190 --> 00:28:39,170
+.. انظر إلى ال ..
+
+252
+00:28:39,170 --> 00:28:44,730
+لا يوجد I ، انظر إلى الـ Spilling فقط تغيّر الـ I
+
+253
+00:28:44,730 --> 00:28:48,310
+إلى E أو تنظفه، تنظفه، كله
+
+254
+00:28:59,740 --> 00:29:06,140
+Thank you and finally knowledge check
+
+255
+00:29:06,140 --> 00:29:08,480
+your answers please
+
+256
+00:29:30,480 --> 00:29:37,580
+Now a few and a few are used with count nouns. A
+
+257
+00:29:37,580 --> 00:29:41,560
+little and little are used with non count nouns.
+
+258
+00:29:41,700 --> 00:29:46,570
+What's the difference between few and a few?little
+
+259
+00:29:46,570 --> 00:29:50,390
+and a little now we know that few and a few used
+
+260
+00:29:50,390 --> 00:29:54,910
+for count little and a little are used for non
+
+261
+00:29:54,910 --> 00:30:00,410
+count now as you see we sang a few songs we
+
+262
+00:30:00,410 --> 00:30:04,500
+listened to a little musicSo a few and a few are
+
+263
+00:30:04,500 --> 00:30:07,280
+used with a plural count a little and little are
+
+264
+00:30:07,280 --> 00:30:10,220
+used with non count Now what's the difference
+
+265
+00:30:10,220 --> 00:30:13,420
+between a few and a few look at this example She
+
+266
+00:30:13,420 --> 00:30:16,520
+has been here only for two weeks but she has
+
+267
+00:30:16,520 --> 00:30:22,940
+already made what a few friends okay a few friends
+
+268
+00:30:22,940 --> 00:30:28,500
+and she has made some friends read the other
+
+269
+00:30:28,500 --> 00:30:32,770
+example yesI'm very pleased I have been able to
+
+270
+00:30:32,770 --> 00:30:37,230
+save a little money this month okay good go on a
+
+271
+00:30:37,230 --> 00:30:40,590
+positive idea I have saved some money instead of
+
+272
+00:30:40,590 --> 00:30:44,450
+spending all of it a few and a little give a
+
+273
+00:30:44,450 --> 00:30:48,850
+positive idea they indicate that something excited
+
+274
+00:30:48,850 --> 00:30:53,190
+in the present thank you now listen I have a
+
+275
+00:30:53,190 --> 00:30:57,450
+little moneyأنا أستطيع أن أشتري صندوق و أستطيع أن
+
+276
+00:30:57,450 --> 00:31:03,750
+أأخذ سيارة لمنزلي، أنا لدي قليل من المال، لا
+
+277
+00:31:03,750 --> 00:31:08,850
+أستطيع أن أشتري صندوق و أستطيع أن أأخذ سيارة
+
+278
+00:31:08,850 --> 00:31:14,230
+لمنزلي،
+
+279
+00:31:14,760 --> 00:31:19,160
+again I have a little I can buy a sandwich and I
+
+280
+00:31:19,160 --> 00:31:25,960
+can take a taxi I have little I cannot do both of
+
+281
+00:31:25,960 --> 00:31:31,320
+that I can only buy a sandwich or take a taxi so a
+
+282
+00:31:31,320 --> 00:31:35,700
+little is used to express what positive situation
+
+283
+00:31:35,700 --> 00:31:41,340
+okay and a few and a few is also positive
+
+284
+00:31:41,340 --> 00:31:46,550
+situationconsidering that this used with count and
+
+285
+00:31:46,550 --> 00:31:51,130
+this is used with non count now if I say I have
+
+286
+00:31:51,130 --> 00:31:55,730
+little petrol in my carCan I go home with this
+
+287
+00:31:55,730 --> 00:31:59,770
+petrol؟ No, I'm afraid the car will stop in the
+
+288
+00:31:59,770 --> 00:32:02,450
+way, in the road, in the way to my house, right?
+
+289
+00:32:03,010 --> 00:32:07,070
+So, but if I have a few, if I have a little,
+
+290
+00:32:07,230 --> 00:32:11,290
+sorry, I can go to my house, it can take me to my
+
+291
+00:32:11,290 --> 00:32:14,270
+house Can you give me some other examples like
+
+292
+00:32:14,270 --> 00:32:22,020
+that? Now, listen, it is still morningand a few
+
+293
+00:32:22,020 --> 00:32:35,560
+students only came to the lecture, can we start؟
+
+294
+00:32:36,170 --> 00:32:41,070
+a few students yes okay a few students we can
+
+295
+00:32:41,070 --> 00:32:46,590
+start but few students we cannot start okay give
+
+296
+00:32:46,590 --> 00:32:50,250
+me other examples yes ياسمين I have little sugar
+
+297
+00:32:50,250 --> 00:32:54,830
+it's not enough to make tea okay it is not enough
+
+298
+00:32:54,830 --> 00:32:59,290
+to make tea little sugar I can't drink this tea it
+
+299
+00:32:59,290 --> 00:33:04,410
+is not enough good we have little water we cannot
+
+300
+00:33:05,760 --> 00:33:08,480
+we cannot wash all the dishes thank you very much
+
+301
+00:33:08,480 --> 00:33:09,740
+good little water
+
+302
+00:33:13,540 --> 00:33:17,620
+Now look at this example read please I feel sorry
+
+303
+00:33:17,620 --> 00:33:21,720
+for her she has very few friends okay she has very
+
+304
+00:33:21,720 --> 00:33:26,860
+few friends look at this sentence she has been
+
+305
+00:33:26,860 --> 00:33:31,060
+here only two weeks but she has already made what
+
+306
+00:33:31,060 --> 00:33:35,280
+a few friends okay this is good she has some
+
+307
+00:33:35,280 --> 00:33:39,660
+friends okay she has some friends but now this one
+
+308
+00:33:39,660 --> 00:33:45,180
+I feel sorrymost of the time she is alone she has
+
+309
+00:33:45,180 --> 00:33:50,240
+only few friends expresses what negative expresses
+
+310
+00:33:50,240 --> 00:33:55,000
+a negative situation okay the other one yes please
+
+311
+00:33:55,000 --> 00:33:59,800
+that's
+
+312
+00:33:59,800 --> 00:34:04,580
+right I have a little I can buy I have a little I
+
+313
+00:34:04,580 --> 00:34:06,400
+can buy I have little
+
+314
+00:34:09,590 --> 00:34:15,550
+I can't buy now few and little without a give a
+
+315
+00:34:15,550 --> 00:34:21,100
+negative idea negative situation okaythey indicate
+
+316
+00:34:21,100 --> 00:34:25,360
+that something is largely absent largely absent I
+
+317
+00:34:25,360 --> 00:34:29,780
+say there are only few students I cannot start the
+
+318
+00:34:29,780 --> 00:34:33,380
+lecture okay because a great number of students
+
+319
+00:34:33,380 --> 00:34:38,960
+are absent now when I say very few and very little
+
+320
+00:34:38,960 --> 00:34:44,660
+this makes the negative strongeremphasizes the
+
+321
+00:34:44,660 --> 00:34:48,500
+meaning yeah emphasizes the amount or the number
+
+322
+00:34:48,500 --> 00:34:54,440
+or whatsoever okay now again who can tell us
+
+323
+00:34:54,440 --> 00:34:56,960
+what's the main difference between a few and a few
+
+324
+00:34:56,960 --> 00:34:59,680
+little and a little yes please
+
+325
+00:35:21,310 --> 00:35:24,190
+Thank you very much. Now look at this exercise in
+
+326
+00:35:24,190 --> 00:35:28,170
+your bookOkay without changing the meaning of the
+
+327
+00:35:28,170 --> 00:35:30,750
+sentence this is very important don't change the
+
+328
+00:35:30,750 --> 00:35:35,810
+meaning replace the Italy sized words with a few
+
+329
+00:35:35,810 --> 00:35:41,130
+very few a little or very little okay now these
+
+330
+00:35:41,130 --> 00:35:44,010
+words are the Italy sized one they are written
+
+331
+00:35:44,010 --> 00:35:48,430
+here with in blue yes your your book they are
+
+332
+00:35:48,430 --> 00:35:52,270
+Italy sized you know Italy sized yes okay
+
+333
+00:35:57,450 --> 00:36:04,050
+number one read it ياسمين a
+
+334
+00:36:04,050 --> 00:36:07,790
+little sunshine is better than none okay a little
+
+335
+00:36:07,790 --> 00:36:10,370
+sunshine is better than none do you agree with the
+
+336
+00:36:10,370 --> 00:36:15,090
+answer okay good next one do number four and five
+
+337
+00:36:15,090 --> 00:36:16,670
+do number four and five
+
+338
+00:36:35,710 --> 00:36:42,130
+Okay number 4 January is a cold and dreary month
+
+339
+00:36:42,130 --> 00:36:47,550
+in the northern states. There is little sunshine
+
+340
+00:36:47,550 --> 00:36:52,990
+during that month.there is little sunshine or
+
+341
+00:36:52,990 --> 00:36:56,630
+there is very little okay or there is very little
+
+342
+00:36:56,630 --> 00:37:02,170
+good thank you very much next one yes please my
+
+343
+00:37:02,170 --> 00:37:05,950
+parents like to watch tv every evening they watch
+
+344
+00:37:05,950 --> 00:37:09,350
+a few programs on tv before they go to bed thank
+
+345
+00:37:09,350 --> 00:37:14,930
+you they watch a few good now
+
+346
+00:37:14,930 --> 00:37:18,470
+do number six seven eight and nine
+
+347
+00:37:21,880 --> 00:37:26,220
+كلنا عشان .. كلنا عشان .. كلنا عشان
+
+348
+00:38:02,340 --> 00:38:11,980
+Okay number six yes please there are
+
+349
+00:38:11,980 --> 00:38:17,060
+few television programs thank you number seven yes
+
+350
+00:38:17,060 --> 00:38:22,280
+please okay
+
+351
+00:38:22,280 --> 00:38:25,680
+thank
+
+352
+00:38:25,680 --> 00:38:29,360
+you good next one yes please
+
+353
+00:38:35,900 --> 00:38:41,500
+Okay thank you
+
+354
+00:38:41,500 --> 00:38:48,620
+good number six what about number six yeah what
+
+355
+00:38:48,620 --> 00:38:56,500
+did she say repeat your answer you did number
+
+356
+00:38:56,500 --> 00:38:59,980
+eight okay repeat it again please
+
+357
+00:39:02,690 --> 00:39:11,190
+Okay thank you and number seven okay
+
+358
+00:39:11,190 --> 00:39:20,510
+a few drops thank you sorry now she did it she did
+
+359
+00:39:20,510 --> 00:39:26,920
+it number nine finally number nineMr Adams doesn't
+
+360
+00:39:26,920 --> 00:39:30,940
+like to wear prints on his fingers, he wears very
+
+361
+00:39:30,940 --> 00:39:34,440
+little shoes thank you check the answers you have
+
+362
+00:39:34,440 --> 00:39:51,060
+the answers okay
+
+363
+00:39:51,060 --> 00:39:53,720
+this exercise do at home please
+
+364
+00:39:56,500 --> 00:40:01,700
+هذه التجربة في المنزل شكرا جزيلا
+
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/6xMcxqJDHg8_raw.json b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/6xMcxqJDHg8_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..e686f0a7a88d9bae21c13998c3e47bda63d54b05
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/6xMcxqJDHg8_raw.json
@@ -0,0 +1 @@
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singular and as plural. Thank you very much. Yes, please next one Two offspring ha no s okay. Yeah next one, please. 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it living thing but look at this word what do you think of this word okay just a minute organism what do you think of this word they are simple", "tokens": [3322, 16998, 2647, 721, 1392, 1309, 291, 808, 293, 3006, 309, 2647, 551, 457, 574, 412, 341, 1349, 437, 360, 291, 519, 295, 341, 1349, 1392, 445, 257, 3456, 24128, 437, 360, 291, 519, 295, 341, 1349, 436, 366, 2199], "avg_logprob": -0.28810975028247365, "compression_ratio": 1.7264957264957266, "no_speech_prob": 0.0, "words": [{"start": 2013.71, "end": 2014.03, "word": "the", "probability": 0.06695556640625}, {"start": 2014.03, "end": 2014.51, "word": " smallest", "probability": 0.91650390625}, {"start": 2014.51, "end": 2015.09, "word": " living", "probability": 0.896484375}, {"start": 2015.09, "end": 2015.71, "word": " things", "probability": 0.7509765625}, {"start": 2015.71, "end": 2021.13, "word": " okay", "probability": 0.2744140625}, {"start": 2021.13, "end": 2021.49, "word": " thank", "probability": 0.7060546875}, {"start": 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clean by hand add this this is enough thank you now", "tokens": [2595, 341, 1349, 24128, 341, 820, 312, 437, 25377, 309, 820, 312, 25377, 22110, 1309, 291, 24128, 572, 445, 909, 341, 909, 341, 500, 380, 2541, 538, 1011, 909, 341, 341, 307, 1547, 1309, 291, 586], "avg_logprob": -0.3112330952206174, "compression_ratio": 1.7075471698113207, "no_speech_prob": 0.0, "words": [{"start": 2044.94, "end": 2045.18, "word": "do", "probability": 0.060699462890625}, {"start": 2045.18, "end": 2045.46, "word": " this", "probability": 0.9208984375}, {"start": 2045.46, "end": 2045.86, "word": " word", "probability": 0.96875}, {"start": 2045.86, "end": 2047.48, "word": " organism", "probability": 0.65234375}, {"start": 2047.48, "end": 2048.54, "word": " this", "probability": 0.826171875}, {"start": 2048.54, "end": 2048.78, "word": " should", "probability": 0.9736328125}, {"start": 2048.78, "end": 2048.98, "word": " be", "probability": 0.9609375}, {"start": 2048.98, "end": 2049.4, "word": " what", 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بلورال بلورال بلورال بلورال بلورال بلورال بلورال بلورال بلورال بلورال بلورال بلورال بلورال بلورال بلورال بلورال بلورال بلورال بلورال بلورال بلورال بلورال بلورال بلورال بلورال بلورال بلورال بلورال", "tokens": [1863, 25957, 27188, 13546, 41779, 3714, 5172, 2655, 2407, 5016, 1975, 5016, 31845, 19913, 47356, 20193, 20193, 20193, 20193, 23758, 4724, 9778, 13546, 27188, 13546, 41779, 12602, 4724, 1211, 13063, 6027, 4032, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027, 4724, 1211, 13063, 6027], "avg_logprob": -0.14805556191338434, "compression_ratio": 8.108695652173912, "no_speech_prob": 0.0, "words": [{"start": 2632.99, "end": 2633.45, "word": "نعم", "probability": 0.547210693359375}, {"start": 2633.45, "end": 2633.91, "word": " الفيروس", "probability": 0.7749837239583334}, {"start": 2633.91, "end": 2634.41, "word": " مفتوح", "probability": 0.384033203125}, {"start": 2634.41, "end": 2634.97, "word": " احافظ", "probability": 0.4620361328125}, {"start": 2634.97, "end": 2635.05, "word": " عليه", "probability": 0.5966796875}, {"start": 2635.05, "end": 2635.41, "word": " لا", "probability": 0.67626953125}, {"start": 2635.41, "end": 2635.55, "word": " لا", "probability": 0.9189453125}, {"start": 2635.55, "end": 2635.73, "word": " لا", "probability": 0.83984375}, {"start": 2635.73, "end": 2635.83, "word": " لا", "probability": 0.162109375}, {"start": 2635.83, "end": 2635.99, "word": " هذا", "probability": 0.58154296875}, {"start": 2635.99, "end": 2636.37, "word": " بخير", "probability": 0.7001953125}, {"start": 2636.37, "end": 2637.41, "word": " الفيروس", "probability": 0.94140625}, {"start": 2637.41, "end": 2637.81, "word": " ر", "probability": 0.11865234375}, {"start": 2637.81, "end": 2639.49, "word": " بلورال", "probability": 0.6376495361328125}, {"start": 2639.49, "end": 2639.63, "word": " و", "probability": 0.58984375}, {"start": 2639.63, "end": 2640.17, "word": " بلورال", "probability": 0.9521484375}, {"start": 2640.17, "end": 2640.17, "word": " بلورال", "probability": 0.6207351684570312}, {"start": 2640.17, "end": 2640.25, "word": " بلورال", "probability": 0.82427978515625}, {"start": 2640.25, "end": 2640.45, "word": " بلورال", "probability": 0.930908203125}, {"start": 2640.45, "end": 2640.53, "word": " بلورال", "probability": 0.93505859375}, {"start": 2640.53, "end": 2640.67, "word": " بلورال", "probability": 0.9063720703125}, {"start": 2640.67, "end": 2640.81, "word": " بلورال", "probability": 0.9012451171875}, {"start": 2640.81, "end": 2641.25, "word": " بلورال", "probability": 0.919921875}, {"start": 2641.25, "end": 2641.45, "word": " بلورال", "probability": 0.937255859375}, {"start": 2641.45, "end": 2641.45, "word": " بلورال", "probability": 0.9500732421875}, {"start": 2641.45, "end": 2641.55, "word": " بلورال", "probability": 0.9586181640625}, {"start": 2641.55, "end": 2641.81, "word": " بلورال", "probability": 0.966064453125}, {"start": 2641.81, "end": 2641.81, "word": " بلورال", "probability": 0.970947265625}, {"start": 2641.81, "end": 2641.81, "word": " بلورال", "probability": 0.9739990234375}, {"start": 2641.81, "end": 2641.81, "word": " بلورال", "probability": 0.9765625}, {"start": 2641.81, "end": 2641.81, "word": " بلورال", "probability": 0.9781494140625}, {"start": 2641.81, "end": 2641.81, "word": " بلورال", "probability": 0.979736328125}, {"start": 2641.81, "end": 2641.81, "word": " بلورال", "probability": 0.9808349609375}, {"start": 2641.81, "end": 2641.81, "word": " بلورال", "probability": 0.9818115234375}, {"start": 2641.81, "end": 2641.81, "word": " بلورال", "probability": 0.982666015625}, {"start": 2641.81, "end": 2641.81, "word": " بلورال", "probability": 0.9833984375}, {"start": 2641.81, "end": 2641.83, "word": " بلورال", "probability": 0.9837646484375}, {"start": 2641.83, "end": 2641.83, "word": " بلورال", "probability": 0.9844970703125}, {"start": 2641.83, "end": 2641.83, "word": " بلورال", "probability": 0.9847412109375}, {"start": 2641.83, "end": 2641.83, "word": " بلورال", "probability": 0.9853515625}, {"start": 2641.83, "end": 2641.87, "word": " بلورال", "probability": 0.985595703125}, {"start": 2641.87, "end": 2641.93, "word": " بلورال", "probability": 0.9859619140625}, {"start": 2641.93, "end": 2641.93, "word": " بلورال", "probability": 0.9862060546875}, {"start": 2641.93, "end": 2641.93, "word": " بلورال", "probability": 0.9864501953125}, {"start": 2641.93, "end": 2641.93, "word": " بلورال", "probability": 0.986328125}, {"start": 2641.93, "end": 2641.93, "word": " بلورال", "probability": 0.986572265625}, {"start": 2641.93, "end": 2642.01, "word": " بلورال", "probability": 0.9866943359375}, {"start": 2642.01, "end": 2642.01, "word": " بلورال", "probability": 0.9869384765625}, {"start": 2642.01, "end": 2642.37, "word": " بلورال", "probability": 0.98681640625}, {"start": 2642.37, "end": 2642.43, "word": " بلورال", "probability": 0.9871826171875}, {"start": 2642.43, "end": 2642.43, "word": " بلورال", "probability": 0.9871826171875}, {"start": 2642.43, "end": 2642.43, "word": " بلورال", "probability": 0.987060546875}, {"start": 2642.43, "end": 2644.67, "word": " بلورال", "probability": 0.9874267578125}, {"start": 2644.67, "end": 2644.83, "word": " بلورال", "probability": 0.987548828125}, {"start": 2644.83, "end": 2645.25, "word": " بلورال", "probability": 0.9871826171875}, {"start": 2645.25, "end": 2645.25, "word": " بلورال", "probability": 0.9876708984375}, {"start": 2645.25, "end": 2646.63, "word": " بلورال", "probability": 0.98779296875}, {"start": 2646.63, "end": 2646.63, "word": " بلورال", "probability": 0.9876708984375}, {"start": 2646.63, "end": 2646.63, "word": " بلورال", "probability": 0.9874267578125}, {"start": 2646.63, "end": 2646.63, "word": " بلورال", "probability": 0.98779296875}, {"start": 2646.63, "end": 2647.67, "word": " بلورال", "probability": 0.988037109375}, {"start": 2647.67, "end": 2647.97, "word": " بلورال", "probability": 0.987548828125}, {"start": 2647.97, "end": 2659.69, "word": " بلورال", "probability": 0.98876953125}], "temperature": 1.0}, {"id": 99, "seek": 268028, "start": 2660.26, "end": 2680.28, "text": "نعم او لا؟ انت محق، انت محق، قبل رقم، نعم، جيد جدا، هذا خطأ أخر حسنا، شكرا جزيلا لليوم", "tokens": [1863, 25957, 1975, 2407, 20193, 22807, 16472, 2655, 3714, 5016, 4587, 12399, 16472, 2655, 3714, 5016, 4587, 12399, 12174, 36150, 12602, 4587, 2304, 12399, 8717, 25957, 12399, 10874, 25708, 10874, 28259, 12399, 23758, 16490, 9566, 10721, 5551, 34740, 11331, 3794, 8315, 12399, 13412, 4117, 23557, 10874, 11622, 1829, 15040, 5296, 20292, 20498], "avg_logprob": -0.41597876683721, "compression_ratio": 1.3873873873873874, "no_speech_prob": 0.0, "words": [{"start": 2660.26, "end": 2660.66, "word": "نعم", "probability": 0.4901123046875}, {"start": 2660.66, "end": 2660.96, "word": " او", "probability": 0.55670166015625}, {"start": 2660.96, "end": 2662.0, "word": " لا؟", "probability": 0.594482421875}, {"start": 2662.0, "end": 2662.12, "word": " انت", "probability": 0.77734375}, {"start": 2662.12, "end": 2663.08, "word": " محق،", "probability": 0.65869140625}, {"start": 2663.08, "end": 2663.52, "word": " انت", "probability": 0.755859375}, {"start": 2663.52, "end": 2664.02, "word": " محق،", "probability": 0.9259033203125}, {"start": 2664.02, "end": 2664.46, "word": " قبل", "probability": 0.4571533203125}, {"start": 2664.46, "end": 2665.26, "word": " رقم،", "probability": 0.712799072265625}, {"start": 2665.26, "end": 2665.7, "word": " نعم،", "probability": 0.71875}, {"start": 2665.7, "end": 2665.8, "word": " جيد", "probability": 0.6558837890625}, {"start": 2665.8, "end": 2666.12, "word": " جدا،", "probability": 0.8797200520833334}, {"start": 2666.12, "end": 2666.28, "word": " هذا", "probability": 0.54443359375}, {"start": 2666.28, "end": 2667.9, "word": " خطأ", "probability": 0.7771809895833334}, {"start": 2667.9, "end": 2667.9, "word": " أخر", "probability": 0.68212890625}, {"start": 2667.9, "end": 2679.14, "word": " حسنا،", "probability": 0.6517333984375}, {"start": 2679.14, "end": 2679.36, "word": " شكرا", "probability": 0.90673828125}, {"start": 2679.36, "end": 2679.56, "word": " جزيلا", "probability": 0.8323974609375}, {"start": 2679.56, "end": 2680.28, "word": " لليوم", "probability": 0.7395833333333334}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2685.5735, "duration_after_vad": 2475.4506249999913}
\ No newline at end of file
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/EPvVKEUooIk_postprocess.srt b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/EPvVKEUooIk_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..6809318256528997df718bc41206a9b5612fd80d
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/EPvVKEUooIk_postprocess.srt
@@ -0,0 +1,2128 @@
+1
+00:00:21,020 --> 00:00:29,120
+Okay good morning to you all how are you دعاء how
+
+2
+00:00:29,120 --> 00:00:33,280
+are you and what about you and again another دعاء
+
+3
+00:00:33,280 --> 00:00:39,140
+ما شاء الله this is nice okay everyday I have
+
+4
+00:00:39,140 --> 00:00:48,700
+breakfast at six what do you do everyday what
+
+5
+00:00:48,700 --> 00:00:49,500
+do you do everyday
+
+6
+00:00:52,940 --> 00:00:56,200
+thank you very much thank you very much now if you
+
+7
+00:00:56,200 --> 00:00:59,300
+look at this sentence animals give us milk and
+
+8
+00:00:59,300 --> 00:01:07,220
+meat okay give computers save us a lot of time now
+
+9
+00:01:07,220 --> 00:01:14,420
+giveIs it connected to a certain tense؟ I mean is
+
+10
+00:01:14,420 --> 00:01:17,480
+it related only to the past, only to the present,
+
+11
+00:01:17,720 --> 00:01:23,140
+only to the future؟ No، so this verb is what؟ Is
+
+12
+00:01:23,140 --> 00:01:27,840
+always true، it is always true، okay؟ It is true
+
+13
+00:01:27,840 --> 00:01:32,570
+in the past, true now and true in the futureSo we
+
+14
+00:01:32,570 --> 00:01:37,170
+call it what an all-time tense or it is timeless
+
+15
+00:01:37,170 --> 00:01:43,030
+okay it is timeless Computer save save this is a
+
+16
+00:01:43,030 --> 00:01:47,330
+fact right they save us a lot of time and effort
+
+17
+00:01:47,330 --> 00:01:54,610
+this tense is calledthe present symbol so what do
+
+18
+00:01:54,610 --> 00:01:58,650
+we use the present symbol for to express yes
+
+19
+00:01:58,650 --> 00:02:05,670
+please نجود facts and habits thank you very much
+
+20
+00:02:05,670 --> 00:02:13,770
+can you give me an example yes please اسمع okay
+
+21
+00:02:13,770 --> 00:02:17,110
+thank you very much ياسمين can you give me another
+
+22
+00:02:17,110 --> 00:02:18,610
+example like that
+
+23
+00:02:37,560 --> 00:02:43,820
+انا أساعد أمي في المطبخ ، حسنًا شكرا جزيلا ، نعم
+
+24
+00:02:43,820 --> 00:02:48,120
+أرجوك ، شكرا
+
+25
+00:02:48,120 --> 00:02:53,090
+جزيلا ، شكرا جزيلاOkay now I take a shower every
+
+26
+00:02:53,090 --> 00:02:57,490
+morning I take a shower every morning it means on
+
+27
+00:02:57,490 --> 00:03:01,770
+Saturday I do it I repeat it on Sunday I repeat on
+
+28
+00:03:01,770 --> 00:03:06,490
+Monday I repeat this is what this is a habit or a
+
+29
+00:03:06,490 --> 00:03:11,470
+repeated action something you do what every day I
+
+30
+00:03:11,470 --> 00:03:16,830
+get up early this means whatكل يوم، كل وقت، هذا
+
+31
+00:03:16,830 --> 00:03:21,910
+دائمًا صحيح دورتي تبقى وقتًا جيدًا أشاهد
+
+32
+00:03:21,910 --> 00:03:25,670
+التليفزيون في أكتر الأيقان، في الأيقان لا أحب
+
+33
+00:03:25,670 --> 00:03:31,670
+الخروج أبقى في المنزل و أشاهد التليفزيون، لذلك مرة
+
+34
+00:03:31,670 --> 00:03:37,970
+أخرى نستخدم معنى الانتقال لإدعاء عادة أو عادة فعل
+
+35
+00:03:37,970 --> 00:03:44,540
+مثلًا، من يمكن يعطيني مثلًا؟ عادة؟ نعم، دعاءvery
+
+36
+00:03:44,540 --> 00:03:48,960
+good thank you yes مريدة every day I drink water
+
+37
+00:03:48,960 --> 00:03:53,400
+thank you very much لما I brush my teeth every day
+
+38
+00:03:53,400 --> 00:04:01,360
+wonderful thank you very much okay this
+
+39
+00:04:01,360 --> 00:04:04,600
+is can you give me this book let me have a look at
+
+40
+00:04:04,600 --> 00:04:09,220
+your book please just give me this book okay look
+
+41
+00:04:09,220 --> 00:04:18,970
+this is a bookit gives us the meanings okay it is
+
+42
+00:04:18,970 --> 00:04:22,750
+a dictionary in fact it also gives us the parts of
+
+43
+00:04:22,750 --> 00:04:30,190
+speech it explains the derivations of the wordsit
+
+44
+00:04:30,190 --> 00:04:36,170
+helps us to increase our vocabulary so it helps it
+
+45
+00:04:36,170 --> 00:04:42,130
+gives it increases it shows it makes studying
+
+46
+00:04:42,130 --> 00:04:46,130
+English easy now I'm talking I'm describing a book
+
+47
+00:04:46,130 --> 00:04:50,090
+okaydescribing the book summarizing a book is
+
+48
+00:04:50,090 --> 00:04:55,230
+called what book review book review when we when
+
+49
+00:04:55,230 --> 00:04:58,970
+you want to make a book review usually you use
+
+50
+00:04:58,970 --> 00:05:05,570
+what the present simple also last time I watched a
+
+51
+00:05:05,570 --> 00:05:12,170
+film it was about sea animals the film shows how
+
+52
+00:05:12,170 --> 00:05:18,160
+animals live live togetherit also focuses on the
+
+53
+00:05:18,160 --> 00:05:25,400
+struggle in the sea، it expresses the way and so
+
+54
+00:05:25,400 --> 00:05:29,480
+on. So when I say shows، expresses، focuses،
+
+55
+00:05:29,480 --> 00:05:36,280
+concentrates، explains، which tense did I use؟Okay
+
+56
+00:05:36,280 --> 00:05:40,280
+again we use the present simple to make what
+
+57
+00:05:40,280 --> 00:05:44,620
+summaries book reviews and film reviews for
+
+58
+00:05:44,620 --> 00:05:47,880
+example Can you tell me about the last book you
+
+59
+00:05:47,880 --> 00:05:52,520
+read The last book you read tell me about the book
+
+60
+00:05:52,520 --> 00:05:55,860
+you read about the film you saw yeah, what did you
+
+61
+00:05:55,860 --> 00:06:00,920
+see? A film you saw tell me about the film. What
+
+62
+00:06:00,920 --> 00:06:07,660
+was the last film you saw? HmmOkay yes please
+
+63
+00:06:07,660 --> 00:06:16,240
+again نوجود last time I saw I saw a film that
+
+64
+00:06:16,240 --> 00:06:20,260
+called thank you for smoking it shows that the
+
+65
+00:06:20,260 --> 00:06:25,700
+company that produce smokes andit shows the
+
+66
+00:06:25,700 --> 00:06:30,680
+company okay it shows it focuses it aims at
+
+67
+00:06:30,680 --> 00:06:34,100
+fighting smoking for example okay thank you very
+
+68
+00:06:34,100 --> 00:06:37,760
+much so this is the film okay now if you want to
+
+69
+00:06:37,760 --> 00:06:41,040
+make to talk about a film to make a summary you
+
+70
+00:06:41,040 --> 00:06:44,140
+use again what the prison symbol i want some more
+
+71
+00:06:44,140 --> 00:06:48,060
+examples go on yes please مروة
+
+72
+00:06:59,720 --> 00:07:05,400
+Okay it talks about a girl okay it shows the girl
+
+73
+00:07:05,400 --> 00:07:09,760
+for example okay
+
+74
+00:07:09,760 --> 00:07:13,240
+thank you it talks it shows it explains it tells
+
+75
+00:07:13,240 --> 00:07:22,260
+and so on okay nowI work at sport shop I work at
+
+76
+00:07:22,260 --> 00:07:27,840
+sport shop now if I want to ask you where does
+
+77
+00:07:27,840 --> 00:07:34,020
+your father work you say he's he he works in that
+
+78
+00:07:34,020 --> 00:07:38,020
+hospital or he's working in that hospital which is
+
+79
+00:07:38,020 --> 00:07:45,290
+right which is right أسمعهو يعمل، جيد، أنت محق،
+
+80
+00:07:45,290 --> 00:07:48,630
+لكن لماذا؟ هل يمكنك أن تخبرني لماذا؟ لماذا لا
+
+81
+00:07:48,630 --> 00:07:49,990
+يعمل؟
+
+82
+00:07:55,920 --> 00:07:59,820
+Okay very good it is so it is a permanent job you
+
+83
+00:07:59,820 --> 00:08:02,920
+want to you she wants to say that this is a
+
+84
+00:08:02,920 --> 00:08:07,620
+permanent job this is an all-time verb it's okay
+
+85
+00:08:07,620 --> 00:08:11,440
+in the past now and in the future okay so this is
+
+86
+00:08:11,440 --> 00:08:14,740
+his job this is his job and he works in this
+
+87
+00:08:14,740 --> 00:08:21,550
+hospital okay he works in this hospital it isI
+
+88
+00:08:21,550 --> 00:08:25,910
+work at a sports shop it's a permanent job his job
+
+89
+00:08:25,910 --> 00:08:29,430
+is to work there the doctor says for example I
+
+90
+00:08:29,430 --> 00:08:35,090
+work in this clinic I work in this clinic the
+
+91
+00:08:35,090 --> 00:08:39,350
+driver says I drive a big lorry okay and so on
+
+92
+00:08:39,350 --> 00:08:47,560
+they live in a very nice flatthey live it is an
+
+93
+00:08:47,560 --> 00:08:54,380
+all-time action or a temporary action all-time
+
+94
+00:08:54,380 --> 00:08:59,240
+action very good okay now if i want to ask you
+
+95
+00:08:59,240 --> 00:09:02,220
+shall i say where are you living or where do you
+
+96
+00:09:02,220 --> 00:09:08,550
+live where are you living or where do you liveOkay
+
+97
+00:09:08,550 --> 00:09:11,430
+thank you but I'm asking which question is right?
+
+98
+00:09:11,550 --> 00:09:14,450
+Shall I ask you where are you living or where do
+
+99
+00:09:14,450 --> 00:09:22,790
+you live?أين تعيش؟ أين تعيش؟ عادة انا أعيش في غزا،
+
+100
+00:09:22,790 --> 00:09:26,450
+انت لا تقول ان انا أعيش في غزا إذا كنت ترغب في
+
+101
+00:09:26,450 --> 00:09:30,910
+زيادة أختك في رفح، على سبيل المثال، في بعض الأيام
+
+102
+00:09:30,910 --> 00:09:38,650
+تقول انا أبقى مع أختي، هذا عمل مجلس، عمل مجلس، عمل
+
+103
+00:09:38,650 --> 00:09:40,390
+مجلس، عمل مجلس، عمل مجلس، عمل مجلس، عمل مجلس، عمل
+
+104
+00:09:40,390 --> 00:09:40,910
+مجلس، عمل مجلس، عمل مجلس، عمل مجلس، عمل مجلس، عمل
+
+105
+00:09:40,910 --> 00:09:43,850
+مجلس، عمل مجلس، عمل مجلس، عمل مجلس، عمل مجلس، عمل
+
+106
+00:09:43,850 --> 00:09:48,490
+مجلس، عمل مجلpresent progressive thank you very
+
+107
+00:09:48,490 --> 00:09:51,590
+much can you give me other examples like that
+
+108
+00:09:51,590 --> 00:09:56,670
+other examples go on give me other examples yes
+
+109
+00:09:56,670 --> 00:10:02,590
+please صحى I live in annasari street very good
+
+110
+00:10:02,590 --> 00:10:07,110
+thank you yes please اسمع I study in the Islamic
+
+111
+00:10:07,110 --> 00:10:10,390
+university I study in the Islamic university very
+
+112
+00:10:10,390 --> 00:10:14,890
+good thank you again go on yes please اسمع بسمع
+
+113
+00:10:14,890 --> 00:10:15,810
+بسمع okay
+
+114
+00:10:18,770 --> 00:10:26,850
+again please my dad works
+
+115
+00:10:26,850 --> 00:10:29,710
+in the islamic university very good thank you very
+
+116
+00:10:29,710 --> 00:10:33,650
+much this is an all-time job thank you yes lama
+
+117
+00:10:33,650 --> 00:10:41,490
+thank you very much okay now what do you think of
+
+118
+00:10:41,490 --> 00:10:45,410
+the weather today what's
+
+119
+00:10:45,410 --> 00:10:46,950
+what do you think of the weather today
+
+120
+00:10:52,300 --> 00:10:57,540
+I think it's very hot very good what do you think
+
+121
+00:10:57,540 --> 00:11:03,000
+of the weather today احلام I think it's very sunny
+
+122
+00:11:03,000 --> 00:11:06,260
+thank you thank you very much what do you think of
+
+123
+00:11:06,260 --> 00:11:11,520
+chocolates نجوة I like it thank you what do you
+
+124
+00:11:11,520 --> 00:11:19,690
+think of fish سجةI don't like it okay what do you
+
+125
+00:11:19,690 --> 00:11:25,790
+think of chicken Suzanne I love it okay I love it
+
+126
+00:11:25,790 --> 00:11:30,490
+now I think I'm expressing what this is a thought
+
+127
+00:11:30,490 --> 00:11:35,850
+I'm expressing my thought about some things okay
+
+128
+00:11:35,850 --> 00:11:41,490
+my feeling I like I love I don't I dislike or I
+
+129
+00:11:41,490 --> 00:11:44,490
+don't like okay this is you are expressing your
+
+130
+00:11:44,490 --> 00:11:49,620
+feelingnext week we are having a holiday somebody
+
+131
+00:11:49,620 --> 00:11:53,920
+says what why why don't we go out this is a
+
+132
+00:11:53,920 --> 00:11:57,800
+negative question to make what okay we use the
+
+133
+00:11:57,800 --> 00:12:02,620
+present simple okay we use so again we use the
+
+134
+00:12:02,620 --> 00:12:07,560
+present simple in what expressing thoughts and
+
+135
+00:12:07,560 --> 00:12:11,600
+feelings okay with negative questions thank you
+
+136
+00:12:11,600 --> 00:12:11,960
+good
+
+137
+00:12:15,700 --> 00:12:21,380
+you didn't do the homeware cream very
+
+138
+00:12:21,380 --> 00:12:26,980
+good I promise I will do okay you didn't come to
+
+139
+00:12:26,980 --> 00:12:31,740
+my office yesterday come
+
+140
+00:12:31,740 --> 00:12:35,120
+thank you very much okay you didn't explain this
+
+141
+00:12:35,120 --> 00:12:42,780
+point yes كريمانI promise I will do okay I promise
+
+142
+00:12:42,780 --> 00:12:47,040
+I will do so look this is another phrase we we use
+
+143
+00:12:47,040 --> 00:12:55,640
+that present simple okay now if I say Palestine is
+
+144
+00:12:55,640 --> 00:13:03,120
+our great love yes اسراء what do you what do you
+
+145
+00:13:03,120 --> 00:13:07,900
+say okay yes
+
+146
+00:13:10,790 --> 00:13:14,590
+I totally agree with you thank you very much it's
+
+147
+00:13:14,590 --> 00:13:20,450
+nice to study English again اسراء I totally agree
+
+148
+00:13:20,450 --> 00:13:24,310
+with you thank you very much okay the weather is
+
+149
+00:13:24,310 --> 00:13:32,710
+hot today ياسمين that I totally I totally agree
+
+150
+00:13:32,710 --> 00:13:40,670
+with you okay again when I say for example yeahI
+
+151
+00:13:40,670 --> 00:13:43,370
+didn't say okay thank you very much I want to say
+
+152
+00:13:43,370 --> 00:13:47,630
+something I want to say dictionaries are very
+
+153
+00:13:47,630 --> 00:13:54,050
+helpful to the students I totally
+
+154
+00:13:54,050 --> 00:13:57,810
+agree with you thank you very much now some
+
+155
+00:13:57,810 --> 00:14:04,270
+elephants can fly what
+
+156
+00:14:04,270 --> 00:14:08,820
+do you think دعا؟I totally disagree with you okay
+
+157
+00:14:08,820 --> 00:14:12,740
+so I totally agree I totally disagree so with
+
+158
+00:14:12,740 --> 00:14:18,480
+phrases like I promise I agree okay the new term
+
+159
+00:14:18,480 --> 00:14:23,620
+starts next week this expresses what future okay
+
+160
+00:14:23,620 --> 00:14:27,820
+so again we can use the symbol to express what
+
+161
+00:14:27,820 --> 00:14:34,490
+okay now listenin the present simple we use the
+
+162
+00:14:34,490 --> 00:14:38,410
+verb without an ending without an ending go come
+
+163
+00:14:38,410 --> 00:14:43,550
+play write sleep clean and so on okay you know the
+
+164
+00:14:43,550 --> 00:14:46,650
+answer most children like ice cream do you like
+
+165
+00:14:46,650 --> 00:14:51,230
+ice cream okay but with the third person singular
+
+166
+00:14:51,230 --> 00:14:57,090
+after he she it the verb ends in what s or es okay
+
+167
+00:14:57,090 --> 00:15:01,530
+it gets cold in winter okay
+
+168
+00:15:02,680 --> 00:15:08,520
+مونة catches the early train catches okay after s
+
+169
+00:15:08,520 --> 00:15:15,140
+sh ch and x we add what okay read the examples
+
+170
+00:15:15,140 --> 00:15:23,400
+please مريدة passes watches catches mixes passes
+
+171
+00:15:23,400 --> 00:15:27,820
+watches catches mixes again please
+
+172
+00:15:30,810 --> 00:15:36,210
+Thank you. Now let's come to the other tense the
+
+173
+00:15:36,210 --> 00:15:41,150
+present progressive or the present continuous the
+
+174
+00:15:41,150 --> 00:15:46,710
+present progressive or continuous okay now you are
+
+175
+00:15:46,710 --> 00:15:52,070
+giving me a book to read okay I say sorry I'm
+
+176
+00:15:52,070 --> 00:15:56,810
+reading a book about wild animals I'm reading a
+
+177
+00:15:56,810 --> 00:16:01,430
+book about wild animals what do you understandهل
+
+178
+00:16:01,430 --> 00:16:04,610
+أنا أقرأ الكتاب في هذه اللحظة؟
+
+179
+00:16:12,750 --> 00:16:16,950
+Okay during this time whenever I have a free time
+
+180
+00:16:16,950 --> 00:16:20,910
+for example I read some pages in the book it means
+
+181
+00:16:20,910 --> 00:16:25,150
+this is what something happening in the extended
+
+182
+00:16:25,150 --> 00:16:29,150
+present it is not necessary now at this point and
+
+183
+00:16:29,150 --> 00:16:33,310
+again it can be at the time of speaking okay what
+
+184
+00:16:33,310 --> 00:16:35,950
+is what are you doing Najwa I am
+
+185
+00:16:40,200 --> 00:16:46,640
+أنا أكتب بعض النقاط أنا أدرس اللغة، شكرا جزيلا،
+
+186
+00:16:46,640 --> 00:16:51,360
+ماذا تفعل يا اسمين؟ أنا أسمعك، شكرا، ماذا تفعل يا
+
+187
+00:16:51,360 --> 00:16:54,720
+سلوى؟ أنا أدرس الإنجليزية انا أدرس الإنجليزية،
+
+188
+00:16:54,720 --> 00:16:59,760
+متى؟ الآن، هذا في وقت التحدث، حسنا؟ هذا في وقت
+
+189
+00:16:59,760 --> 00:17:03,240
+التحدث، لذلك الـ progressive الـ present
+
+190
+00:17:03,240 --> 00:17:08,580
+progressiveExpresses an action which is happening
+
+191
+00:17:08,580 --> 00:17:12,560
+now at the time of speaking I'm talking I'm
+
+192
+00:17:12,560 --> 00:17:16,760
+writing I'm playing I'm eating I'm watching or it
+
+193
+00:17:16,760 --> 00:17:21,760
+can also express something or an example an action
+
+194
+00:17:21,760 --> 00:17:24,480
+in the extended present something you are not
+
+195
+00:17:24,480 --> 00:17:30,360
+doing now at this moment okay but these days okay
+
+196
+00:17:31,800 --> 00:17:39,360
+الأن قالت أن أختي ستتزوج الأسبوع التالي قالت نحن
+
+197
+00:17:39,360 --> 00:17:45,500
+نستعد للعادة نحن نستعد للعادة، هل هي تستعد الأن في
+
+198
+00:17:45,500 --> 00:17:50,780
+هذه الوقت؟ لا، حسنًا، هل
+
+199
+00:17:50,780 --> 00:17:58,900
+تتذكر مثلًا؟ أنا أعمل في مقهى الرياضة، كان هذا وقت
+
+200
+00:17:58,900 --> 00:18:05,750
+مستمر؟job thank you now when I say I'm working at
+
+201
+00:18:05,750 --> 00:18:11,130
+this sports shop for six weeks temporary temporary
+
+202
+00:18:11,130 --> 00:18:19,790
+job now if I want to talk about myself shall I say
+
+203
+00:18:19,790 --> 00:18:24,750
+I'm teaching grammar or I teach grammar please
+
+204
+00:18:24,750 --> 00:18:30,840
+please okay yeahI'm teaching grammar very good I'm
+
+205
+00:18:30,840 --> 00:18:34,680
+teaching grammar because I'm teaching grammar only
+
+206
+00:18:34,680 --> 00:18:38,020
+this semester last semester I did not teach
+
+207
+00:18:38,020 --> 00:18:42,160
+grammar next semester I don't know whether I'm
+
+208
+00:18:42,160 --> 00:18:46,400
+going to teach it or not okay so teaching grammar
+
+209
+00:18:46,400 --> 00:18:51,380
+for me is what temporary job okay something you do
+
+210
+00:18:51,380 --> 00:18:57,320
+temporarily now againإذا كنت ترغب في التقرير بين
+
+211
+00:18:57,320 --> 00:19:03,280
+إسم الحجب والمتقدس، فتفكر إذا كانت الحركة مستمرة
+
+212
+00:19:03,280 --> 00:19:10,820
+أو مقتصرة إذا كانت مستمرة أو مقتصرة. الان نيفين
+
+213
+00:19:10,820 --> 00:19:18,340
+تعمل كيكات جيدة، صح نيفين؟ نيفين تعمل كيكات جيدة،
+
+214
+00:19:18,340 --> 00:19:23,130
+هل هي تعمل كيكات الأن؟is she in the kitchen now?
+
+215
+00:19:23,670 --> 00:19:28,670
+no okay she's a good cakes maker right but it is
+
+216
+00:19:28,670 --> 00:19:32,030
+not her this is old time when she was a child she
+
+217
+00:19:32,030 --> 00:19:35,990
+learned how to make cakes and she's still and
+
+218
+00:19:35,990 --> 00:19:39,610
+she's still but if you ask me where is navin she's
+
+219
+00:19:39,610 --> 00:19:45,370
+making a cake she must be in the kitchen okay she
+
+220
+00:19:45,370 --> 00:19:48,970
+must be in the kitchen okay can you give me other
+
+221
+00:19:48,970 --> 00:19:58,150
+examples like thatthink of similar examples yes
+
+222
+00:19:58,150 --> 00:20:03,310
+موريدا my brother is a football player if you ask
+
+223
+00:20:03,310 --> 00:20:07,770
+me where is my brother I told you he's playing
+
+224
+00:20:07,770 --> 00:20:12,290
+right now okay he's playing in the okay he's
+
+225
+00:20:12,290 --> 00:20:15,010
+playing right now at this moment thank you very
+
+226
+00:20:15,010 --> 00:20:19,630
+much okay now when I say yes please
+
+227
+00:20:24,970 --> 00:20:29,010
+my sister is teaching English right now it means
+
+228
+00:20:29,010 --> 00:20:33,210
+she is a teacher of English okay and she's at this
+
+229
+00:20:33,210 --> 00:20:36,530
+moment she's in the class okay at this moment
+
+230
+00:20:36,530 --> 00:20:43,590
+she's in the class okay now Nada is a good short
+
+231
+00:20:43,590 --> 00:20:49,330
+story writerOkay is a good short story writer
+
+232
+00:20:49,330 --> 00:20:52,550
+shall I say she writes short stories or she's
+
+233
+00:20:52,550 --> 00:21:00,410
+writing She writes or she's writing yes please
+
+234
+00:21:03,080 --> 00:21:07,860
+she writes very good she writes short stories it
+
+235
+00:21:07,860 --> 00:21:11,540
+is not necessary okay maybe she's sleeping now
+
+236
+00:21:11,540 --> 00:21:15,120
+okay she's sleeping and you want to talk about her
+
+237
+00:21:15,120 --> 00:21:20,580
+oh where is وفا where is ندا okay she's sleeping
+
+238
+00:21:20,580 --> 00:21:25,860
+what about her she writes good short stories she
+
+239
+00:21:25,860 --> 00:21:29,520
+writes nice short stories okay but now she's not
+
+240
+00:21:29,520 --> 00:21:36,930
+doing she's not writing at this timeالأن هم يعيشون
+
+241
+00:21:36,930 --> 00:21:44,490
+في منزل صغير جدًا، هل تتذكر المثال السابق؟ هم
+
+242
+00:21:44,490 --> 00:21:52,210
+يعيشون في منزل جميل، في منزل كبير، ولكن هم يعيشون،
+
+243
+00:21:52,210 --> 00:21:58,510
+هذا يعني، نعم، عملية موقعية، إنها عملية موقعية،
+
+244
+00:21:58,510 --> 00:21:58,910
+شكرا
+
+245
+00:22:06,270 --> 00:22:12,270
+would you read the example please yes read okay
+
+246
+00:22:12,270 --> 00:22:15,770
+i'm all thank you i'm always making silly mistakes
+
+247
+00:22:15,770 --> 00:22:20,790
+in the exam okay i'm always making i'm always
+
+248
+00:22:20,790 --> 00:22:27,050
+making silly mistakes i'm always you remember okay
+
+249
+00:22:27,050 --> 00:22:30,390
+okay i'm always making what does it mean
+
+250
+00:22:37,300 --> 00:22:43,740
+we very very often very often okay or too often
+
+251
+00:22:43,740 --> 00:22:50,140
+too often now when i say i always make silly
+
+252
+00:22:50,140 --> 00:22:54,740
+mistakes in the exam it means what every time it
+
+253
+00:22:54,740 --> 00:23:01,050
+means every time i'm always makingit means very
+
+254
+00:23:01,050 --> 00:23:05,810
+often or too often but not every time so always
+
+255
+00:23:05,810 --> 00:23:12,410
+with the present symbol means every time okay I
+
+256
+00:23:12,410 --> 00:23:15,810
+always come early to the university it means every
+
+257
+00:23:15,810 --> 00:23:20,810
+day I come early okay I'm always coming it means
+
+258
+00:23:20,810 --> 00:23:25,830
+most of the times I do but sometimes I don't okay
+
+259
+00:23:25,830 --> 00:23:31,350
+so again who can repeat this pointalways when used
+
+260
+00:23:31,350 --> 00:23:33,850
+with the present simple what does it mean and when
+
+261
+00:23:33,850 --> 00:23:37,950
+used with the progressive what does it mean?
+
+262
+00:23:38,850 --> 00:23:43,790
+present simple we use it all the time to mean
+
+263
+00:23:43,790 --> 00:23:49,690
+every time and present progressive we use very
+
+264
+00:23:49,690 --> 00:23:52,970
+often okay thank you to mean very often can you
+
+265
+00:23:52,970 --> 00:23:56,350
+give me examples like thatCan you give me
+
+266
+00:23:56,350 --> 00:24:00,290
+examples? Think of a similar example I'm always
+
+267
+00:24:00,290 --> 00:24:11,630
+listening to music I'm always getting up
+
+268
+00:24:11,630 --> 00:24:20,690
+early It means sometimes she doesn't I'm
+
+269
+00:24:20,690 --> 00:24:24,200
+always helping my friendI always helping my
+
+270
+00:24:24,200 --> 00:24:29,080
+friends thank you very much yeah I'm always
+
+271
+00:24:29,080 --> 00:24:33,200
+catching the bus or I always catch the bus I
+
+272
+00:24:33,200 --> 00:24:36,460
+always catch so every time you come with okay bye
+
+273
+00:24:36,460 --> 00:24:42,120
+bus thank you very much yes please I always tidy
+
+274
+00:24:42,120 --> 00:24:45,440
+up okay it means nobody does that for her every
+
+275
+00:24:45,440 --> 00:24:50,820
+time she does okay thank you very much nowalways
+
+276
+00:24:50,820 --> 00:24:54,040
+also can be used with the present progressive to
+
+277
+00:24:54,040 --> 00:24:58,920
+express what? look at this example how is your
+
+278
+00:24:58,920 --> 00:25:02,740
+little sister lama? lama has a very little sister
+
+279
+00:25:02,740 --> 00:25:10,160
+a very nice baby but she's always crying she's
+
+280
+00:25:10,160 --> 00:25:17,790
+always crying okayانها دائما تبكي وهذا يعني ماذا؟
+
+281
+00:25:17,790 --> 00:25:26,910
+موضوع نقلي، انا اتكلم، انها دائما تبكي، تعرف لماذا
+
+282
+00:25:26,910 --> 00:25:31,880
+الباب مغلق؟because the students outside are always
+
+283
+00:25:31,880 --> 00:25:36,000
+making noise they are always making noise this is
+
+284
+00:25:36,000 --> 00:25:40,680
+a negative situation when I ask you why did you
+
+285
+00:25:40,680 --> 00:25:45,560
+stop talking to her she's always nagging okay
+
+286
+00:25:45,560 --> 00:25:50,920
+she's always nagging okay nagging you know nagging
+
+287
+00:25:50,920 --> 00:25:58,000
+okayOkay she is always nagging a negative equality
+
+288
+00:25:58,000 --> 00:26:02,500
+that's why I stopped talking to her again give me
+
+289
+00:26:02,500 --> 00:26:08,460
+other similar examples with always my brother is
+
+290
+00:26:08,460 --> 00:26:11,940
+always bothering me very good my brother is always
+
+291
+00:26:11,940 --> 00:26:17,360
+bothering me okay thank you yeah I'm always
+
+292
+00:26:17,360 --> 00:26:22,870
+revising my lecturesI'm always watch okay revising
+
+293
+00:26:22,870 --> 00:26:25,730
+my lectures okay thank you very much this is a
+
+294
+00:26:25,730 --> 00:26:27,910
+good sentence but does it express a negative
+
+295
+00:26:27,910 --> 00:26:35,090
+situation negative situation in
+
+296
+00:26:35,090 --> 00:26:40,250
+this sense thank you very much thank you very much
+
+297
+00:26:40,250 --> 00:26:44,030
+thank you okay now he's complaining about his son
+
+298
+00:26:44,030 --> 00:26:49,430
+his son in he's always watching tvhe's always
+
+299
+00:26:49,430 --> 00:26:55,270
+watching TV okay he's very fat اه he's always
+
+300
+00:26:55,270 --> 00:27:02,590
+eating he's always sleeping and so on now
+
+301
+00:27:02,590 --> 00:27:07,290
+let's come to state verbs and action verbs okay
+
+302
+00:27:07,290 --> 00:27:11,950
+state verbs and action verbs states
+
+303
+00:27:14,290 --> 00:27:19,170
+we can say stative verbs or non-action verbs the
+
+304
+00:27:19,170 --> 00:27:23,090
+same thing okay what is a state a state means
+
+305
+00:27:23,090 --> 00:27:27,390
+something is staying the same okay staying the
+
+306
+00:27:27,390 --> 00:27:33,750
+same the flat is clean the farmer owns the box
+
+307
+00:27:33,750 --> 00:27:39,090
+contained okay state verbs cannot usually be any
+
+308
+00:27:39,090 --> 00:27:41,150
+progressive what do you think of this sentence
+
+309
+00:27:41,150 --> 00:27:43,030
+Suzanne would you read it
+
+310
+00:27:47,590 --> 00:27:51,550
+read it okay
+
+311
+00:27:51,550 --> 00:27:54,670
+thank you is owning the land what do you think of
+
+312
+00:27:54,670 --> 00:27:57,850
+this sentence what do you think of this sentence
+
+313
+00:27:57,850 --> 00:28:06,270
+okay yes what do you think of this sentence the
+
+314
+00:28:06,270 --> 00:28:11,830
+farmer is owning the land false very good thank
+
+315
+00:28:11,830 --> 00:28:16,350
+you very much can you tell me why it is false yes
+
+316
+00:28:16,350 --> 00:28:23,030
+pleasestate fair thank you it means it doesn't
+
+317
+00:28:23,030 --> 00:28:27,690
+accept ing okay it doesn't accept the ing thank
+
+318
+00:28:27,690 --> 00:28:34,050
+you and action means something happening eating
+
+319
+00:28:34,050 --> 00:28:39,130
+writing playing going coming and jumping taking
+
+320
+00:28:39,130 --> 00:28:46,110
+and so on now read the first example pleaseI'm
+
+321
+00:28:46,110 --> 00:28:50,670
+cleaning the flat this is an action verb we used و
+
+322
+00:28:50,670 --> 00:28:54,270
+the progressive again yes please read the other
+
+323
+00:28:54,270 --> 00:29:01,530
+example yes the farmer is buying the land thank
+
+324
+00:29:01,530 --> 00:29:06,810
+you very much the farmer is buying the land okay
+
+325
+00:29:06,810 --> 00:29:14,030
+غدير yes please read this example your name is غدا
+
+326
+00:29:14,030 --> 00:29:15,390
+okay yes غدا
+
+327
+00:29:18,310 --> 00:29:22,050
+thank you very much he put the box in the box
+
+328
+00:29:22,050 --> 00:29:28,490
+what's the tense here what's the tense here yeah
+
+329
+00:29:28,490 --> 00:29:33,790
+she says it is possible do you agree with دعاء why
+
+330
+00:29:33,790 --> 00:29:40,090
+not uh-huh i think it's present yeah
+
+331
+00:29:41,850 --> 00:29:45,790
+passed because if it is present you should use
+
+332
+00:29:45,790 --> 00:29:51,370
+what yes he pots okay this is present right she
+
+333
+00:29:51,370 --> 00:29:54,650
+pots this is present but he pot this is what
+
+334
+00:29:54,650 --> 00:29:58,230
+passed okay read the other example
+
+335
+00:30:01,460 --> 00:30:05,440
+thank you very much now he put okay this is simple
+
+336
+00:30:05,440 --> 00:30:09,160
+and this is progressive so the action verbs can be
+
+337
+00:30:09,160 --> 00:30:13,380
+used in the symbol or in the progressive you can
+
+338
+00:30:13,380 --> 00:30:18,060
+use them but state verbs are usually used in the
+
+339
+00:30:18,060 --> 00:30:24,500
+okay what do you read can you see the examples the
+
+340
+00:30:24,500 --> 00:30:31,500
+wordsyes yes son what what are these state verbs
+
+341
+00:30:31,500 --> 00:30:38,160
+yes read them please go on yes read yeah
+
+342
+00:30:55,690 --> 00:31:03,430
+Okay thank you very much thank you these are some
+
+343
+00:31:03,430 --> 00:31:10,610
+some means we have okay thank you state or action
+
+344
+00:31:13,110 --> 00:31:18,230
+Sometimes we can use a verb either for state or
+
+345
+00:31:18,230 --> 00:31:22,830
+for an action it means the same verb can be used
+
+346
+00:31:22,830 --> 00:31:27,810
+what to express a state or to express an action
+
+347
+00:31:27,810 --> 00:31:34,830
+okay now when I say I think English is a good
+
+348
+00:31:34,830 --> 00:31:41,310
+field or a good language to studyI think I believe
+
+349
+00:31:41,310 --> 00:31:47,270
+I think Islam is the best religion I believe I
+
+350
+00:31:47,270 --> 00:31:53,910
+think the weather is hot today I believe okay I
+
+351
+00:31:53,910 --> 00:31:59,290
+believe but look at Rawand Rawand saw an accident
+
+352
+00:31:59,290 --> 00:32:04,070
+in the morning what are you thinking of I'm
+
+353
+00:32:04,070 --> 00:32:09,720
+thinking ofthe accident okay i'm thinking of the
+
+354
+00:32:09,720 --> 00:32:15,120
+accident i'm thinking of okay yasmin is having an
+
+355
+00:32:15,120 --> 00:32:18,680
+exam tomorrow what are you thinking of yasmin i'm
+
+356
+00:32:18,680 --> 00:32:24,700
+thinking of the exam okay suha did not have
+
+357
+00:32:24,700 --> 00:32:29,520
+breakfast today what are you thinking of suha i'm
+
+358
+00:32:29,520 --> 00:32:35,310
+thinking of havingbreakfast okay so again I'm
+
+359
+00:32:35,310 --> 00:32:40,150
+thinking of I'm thinking of this is a mental
+
+360
+00:32:40,150 --> 00:32:45,630
+process a mental process okay I'm thinking I'm
+
+361
+00:32:45,630 --> 00:32:48,430
+thinking of the exam I'm thinking of my children
+
+362
+00:32:48,430 --> 00:32:52,490
+I'm thinking of this problem I'm thinking of a
+
+363
+00:32:52,490 --> 00:32:59,050
+mental process but I think I believe meansنحن لا
+
+364
+00:32:59,050 --> 00:33:02,330
+نستخدم الان جي نحن لا نستخدم ال progressive حسنًا
+
+365
+00:33:02,330 --> 00:33:10,730
+الآن لدينا ثلاث سيارات لدينا .. لدينا .. انا لدي
+
+366
+00:33:10,730 --> 00:33:16,240
+رسالة ردCan I use the ing with it? No, but can I
+
+367
+00:33:16,240 --> 00:33:19,880
+say I'm having a sandwich? We are having grammar
+
+368
+00:33:19,880 --> 00:33:22,940
+now. We are having grammar. We are studying
+
+369
+00:33:22,940 --> 00:33:26,520
+grammar. I'm having a sandwich. I'm eating. I'm
+
+370
+00:33:26,520 --> 00:33:30,840
+having tea. I'm drinking and so on. Okay. So
+
+371
+00:33:30,840 --> 00:33:37,340
+again, I come from Palestine. I come from
+
+372
+00:33:37,340 --> 00:33:41,420
+Palestine. Yeah.that's right thank you very much
+
+373
+00:33:41,420 --> 00:33:45,660
+now when i ask you where do you come from i come
+
+374
+00:33:45,660 --> 00:33:52,860
+from palestine okay morsi comes from egypt sisi
+
+375
+00:33:52,860 --> 00:33:59,400
+also comes from egypt و الله أعلم okay and yes sir
+
+376
+00:33:59,400 --> 00:34:03,540
+arafat comes from palestine where do you come from
+
+377
+00:34:03,540 --> 00:34:08,400
+i come from palestine okay but where are you
+
+378
+00:34:08,400 --> 00:34:09,200
+coming from
+
+379
+00:34:12,030 --> 00:34:17,070
+Where are you coming from I'm coming from my house
+
+380
+00:34:17,070 --> 00:34:20,910
+very good I'm coming from the library I'm coming
+
+381
+00:34:20,910 --> 00:34:26,630
+from the kitchen right okay so you can say I'm
+
+382
+00:34:26,630 --> 00:34:30,750
+coming from Palestine I'm traveling for example I
+
+383
+00:34:30,750 --> 00:34:35,110
+see your problem I understand your problem okay
+
+384
+00:34:35,110 --> 00:34:42,570
+can you seethe door that door can you what see her
+
+385
+00:34:42,570 --> 00:34:46,710
+have in sight we are talking about the sight okay
+
+386
+00:34:46,710 --> 00:34:52,290
+but when i say she's seeing the doctor today she's
+
+387
+00:34:52,290 --> 00:34:57,910
+meeting okay she's meeting this
+
+388
+00:34:57,910 --> 00:35:00,250
+picture yes would you read the other examples
+
+389
+00:35:00,250 --> 00:35:04,390
+thank you
+
+390
+00:35:08,160 --> 00:35:16,460
+Okay thank you yes please go on appears means
+
+391
+00:35:16,460 --> 00:35:27,380
+seems thank you next one okay she appeared okay
+
+392
+00:35:27,380 --> 00:35:30,520
+thank you very much okay again please read this
+
+393
+00:35:30,520 --> 00:35:33,340
+one with
+
+394
+00:35:35,550 --> 00:35:42,670
+thank you very much next one please read thank
+
+395
+00:35:42,670 --> 00:35:48,690
+you very much and finally the coat okay the coat
+
+396
+00:35:48,690 --> 00:35:53,870
+fits yeah thank you the coat fits means the the
+
+397
+00:35:53,870 --> 00:36:04,010
+right size and i am i am fittingالقفل للمفتاح اللي
+
+398
+00:36:04,010 --> 00:36:08,570
+انا اقوم بإصلاحه حسنا، و من يقدر يقرر الفكرة؟ من
+
+399
+00:36:08,570 --> 00:36:10,890
+يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر
+
+400
+00:36:10,890 --> 00:36:12,070
+يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر
+
+401
+00:36:12,070 --> 00:36:13,410
+يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر
+
+402
+00:36:13,410 --> 00:36:14,010
+يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر
+
+403
+00:36:14,010 --> 00:36:17,210
+يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر
+
+404
+00:36:17,210 --> 00:36:25,350
+يقدر
+
+405
+00:36:25,350 --> 00:36:26,050
+ي
+
+406
+00:36:34,380 --> 00:36:40,080
+Okay thank you very much good okay so stative
+
+407
+00:36:40,080 --> 00:36:45,200
+verbs don't accept ing okay are not used in the
+
+408
+00:36:45,200 --> 00:36:53,450
+progressiveإذا في بعض الأحيان لديهم معنية أخرى و
+
+409
+00:36:53,450 --> 00:36:56,450
+عندما يكون لديهم معنية أخرى يمكن أن يكونوا
+
+410
+00:36:56,450 --> 00:37:00,890
+مستخدمين في الـ Progressive. حسنًا، ماذا عن الـ
+
+411
+00:37:00,890 --> 00:37:09,370
+Verbi؟ عندما أقول إنه شخص مرتبط جدًا، حسنًا؟ أبوك
+
+412
+00:37:09,370 --> 00:37:14,820
+جاد جدًاyour father is very generous he's a good
+
+413
+00:37:14,820 --> 00:37:20,500
+teacher she's a kind person this is what expresses
+
+414
+00:37:20,500 --> 00:37:25,440
+a permanent or a temporary thing permanent it
+
+415
+00:37:25,440 --> 00:37:29,000
+means when i say your father is so generous is so
+
+416
+00:37:29,000 --> 00:37:34,320
+kind he's always saw he's always saw okay when i
+
+417
+00:37:34,320 --> 00:37:38,380
+say she's very clever she's very intelligent she's
+
+418
+00:37:38,380 --> 00:37:45,310
+always saw okay nowbut that man is an idiot okay
+
+419
+00:37:45,310 --> 00:37:51,630
+that man it is you know always he's silly he's not
+
+420
+00:37:51,630 --> 00:37:57,910
+wise okay when i say mona is being very sociable
+
+421
+00:37:57,910 --> 00:38:01,930
+today it
+
+422
+00:38:01,930 --> 00:38:07,910
+means she is not always hot okaywhen I tell you
+
+423
+00:38:07,910 --> 00:38:12,670
+some students that you are being so active today
+
+424
+00:38:12,670 --> 00:38:18,910
+it means she is only today this is not the case
+
+425
+00:38:18,910 --> 00:38:28,580
+with her but you are very active it meansعندما
+
+426
+00:38:28,580 --> 00:38:34,340
+يقابلك صديقك لحلوة، تعال و أحصل على حلوة معي، ماذا
+
+427
+00:38:34,340 --> 00:38:38,260
+يجب أن تقول؟ أنت كذلك عزيزي اليوم أو أنت عزيزي؟
+
+428
+00:38:38,260 --> 00:38:43,760
+أنت كذلك عزيزي، لماذا تقول ذلك؟ و عند ماذا؟ لأنها
+
+429
+00:38:43,760 --> 00:38:48,400
+لوقت طويل، ليس دائمًا. حسنًا ليس دائمًا، و ربما
+
+430
+00:38:48,400 --> 00:38:54,640
+إذا كنت تعرف أنها عزيزة،انها عزيزة انت تقول انك
+
+431
+00:38:54,640 --> 00:38:58,380
+عزيزة جدا انت عزيزة جدا ولكن اذا كنت تعرف انها لا
+
+432
+00:38:58,380 --> 00:39:04,440
+يمكنها فعلا تفعل ذلك انت تقول انك عزيزة انت عزيزة
+
+433
+00:39:04,440 --> 00:39:10,520
+شكرا انت عزيزة انت عزيزة انت عزيزة انت عزيزة انت
+
+434
+00:39:10,520 --> 00:39:15,060
+عزيزة انت عزيزة انت عزيزة انت عزيزة انت عزيزة انت
+
+435
+00:39:15,060 --> 00:39:20,520
+عزيزة انت عزيزة انت عزيزة انت عزيزةنحن نستخدم am و
+
+436
+00:39:20,520 --> 00:39:26,340
+are لتتحدث فقط عن الوضع و ليس عن أشياء أخرى هل
+
+437
+00:39:26,340 --> 00:39:31,000
+يمكنك أن تقرأ أرجوك انا انا صغيرة الان انا صغيرة
+
+438
+00:39:31,000 --> 00:39:39,540
+الان هل انت جاهز؟ شكرا
+
+439
+00:39:39,540 --> 00:39:47,250
+يعجب و يعجب حبloving enjoy enjoying what's the
+
+440
+00:39:47,250 --> 00:39:53,970
+difference okay what's the difference again do you
+
+441
+00:39:53,970 --> 00:39:57,270
+remember what's the difference between the simple
+
+442
+00:39:57,270 --> 00:40:00,790
+and the progressive one of the differences is that
+
+443
+00:40:00,790 --> 00:40:04,950
+we use the symbol to talk about permanent
+
+444
+00:40:04,950 --> 00:40:09,190
+situations okay and we talk about the symbol
+
+445
+00:40:16,120 --> 00:40:21,980
+عندما أقول أنني أحب أن أستمتع بالجمهورية عندما
+
+446
+00:40:21,980 --> 00:40:26,700
+يقابلني شخص ما فأنا أذهب بسرعة و أقابل الجمهورية
+
+447
+00:40:26,700 --> 00:40:33,400
+أنا أحب المدرسةخطوات السنة تكلف الكثير من المال،
+
+448
+00:40:33,400 --> 00:40:38,380
+هذا عاملا، وهذا دائما حالي، لكن أنا أحب أن أستمتع
+
+449
+00:40:38,380 --> 00:40:42,360
+بهذه الحفلة، تعرفين؟ أنا لا أحب الحفلات، لكن لأن
+
+450
+00:40:42,360 --> 00:40:48,420
+هذه حفلة لك و أنت صديقيأنا أحب هذه المجتمع، أنا
+
+451
+00:40:48,420 --> 00:40:54,000
+أستمتع بهذه الدراسة، أنا لا أحب الدراسات، أنا لا
+
+452
+00:40:54,000 --> 00:40:57,560
+أحب الدراسات الكلمية، لكن أنا أستمتع فقط بدراسة
+
+453
+00:40:57,560 --> 00:41:00,740
+كلمة كلمة كلمة كلمة كلمة كلمة كلمة كلمة كلمة كلمة
+
+454
+00:41:00,740 --> 00:41:02,700
+كلمة كلمة كلمة كلمة كلمة كلمة كلمة كلمة كلمة كلمة
+
+455
+00:41:02,700 --> 00:41:03,620
+كلمة كلمة كلمة كلمة كلمة كلمة كلمة كلمة كلمة كلمة
+
+456
+00:41:03,620 --> 00:41:11,940
+كلمة كلمة كلمة كلمة
+
+457
+00:41:11,940 --> 00:41:19,930
+كSo sometimes they are used in the same meaning
+
+458
+00:41:19,930 --> 00:41:23,810
+with the progressive and in the simple We feel a
+
+459
+00:41:23,810 --> 00:41:31,730
+bit sad or we are feeling a bit sad Now
+
+460
+00:41:31,730 --> 00:41:36,330
+we want to make a summary of what we studied today
+
+461
+00:41:37,700 --> 00:41:42,260
+Okay can you help me please to summarize the main
+
+462
+00:41:42,260 --> 00:41:46,340
+points what did we talk about today what did we
+
+463
+00:41:46,340 --> 00:41:54,380
+talk about today yes please yes the present simple
+
+464
+00:41:54,380 --> 00:42:00,460
+good and the present progressive thank you very
+
+465
+00:42:00,460 --> 00:42:05,370
+much thank youNow think of one point each of you
+
+466
+00:42:05,370 --> 00:42:08,270
+I'd like you all to take part in discussion okay
+
+467
+00:42:08,270 --> 00:42:11,950
+just think of one point and give me we said so
+
+468
+00:42:11,950 --> 00:42:15,950
+much so we talked about so many points okay so
+
+469
+00:42:15,950 --> 00:42:18,530
+give me a point about what we said today و لا
+
+470
+00:42:18,530 --> 00:42:23,410
+thank
+
+471
+00:42:23,410 --> 00:42:27,430
+you very much good
+
+472
+00:42:32,960 --> 00:42:42,040
+ندا very good thank you very much السحر okay
+
+473
+00:42:42,040 --> 00:42:46,120
+what did we say what did we say about action verbs
+
+474
+00:42:46,120 --> 00:42:49,980
+okay
+
+475
+00:42:49,980 --> 00:42:53,900
+thank
+
+476
+00:42:53,900 --> 00:42:56,560
+you very much good what else yes please
+
+477
+00:43:08,140 --> 00:43:10,920
+temporary okay thank you very much yes please
+
+478
+00:43:10,920 --> 00:43:12,160
+situation
+
+479
+00:43:25,140 --> 00:43:27,640
+every time thank you very much very good yes
+
+480
+00:43:27,640 --> 00:43:33,700
+please yes you wanted to say something okay yeah
+
+481
+00:43:33,700 --> 00:43:38,480
+thank
+
+482
+00:43:38,480 --> 00:43:41,920
+you
+
+483
+00:43:41,920 --> 00:43:53,300
+very much good yes please with the
+
+484
+00:43:53,300 --> 00:43:58,240
+same meaningwith different meanings just a minute
+
+485
+00:43:58,240 --> 00:44:00,300
+just a minute please again could you please repeat
+
+486
+00:44:00,300 --> 00:44:04,560
+what did you say with
+
+487
+00:44:04,560 --> 00:44:11,840
+no
+
+488
+00:44:11,840 --> 00:44:16,440
+difference in meaning thank you can you give me an
+
+489
+00:44:16,440 --> 00:44:21,040
+example the progressive and the simple with no
+
+490
+00:44:21,040 --> 00:44:22,960
+difference in meaning can you give me an example
+
+491
+00:44:22,960 --> 00:44:23,640
+yes please
+
+492
+00:44:27,920 --> 00:44:30,800
+we are feeling thank you very much good we feel
+
+493
+00:44:30,800 --> 00:44:34,020
+and we are feeling thank you very much now which
+
+494
+00:44:34,020 --> 00:44:37,760
+is better to ask you how are you feeling today or
+
+495
+00:44:37,760 --> 00:44:41,800
+how do you feel today raise your hands please
+
+496
+00:44:41,800 --> 00:44:46,320
+which is better how are you feeling today or how
+
+497
+00:44:46,320 --> 00:44:51,380
+do you feel today yes please how do you feel thank
+
+498
+00:44:51,380 --> 00:44:59,880
+you how do you feel thank youكيف تشعر اليوم؟ شكرا
+
+499
+00:44:59,880 --> 00:45:05,120
+لك لذا لدينا اتصالين احدهم صح كيف تشعر؟ كيف تشعر؟
+
+500
+00:45:05,120 --> 00:45:12,460
+من يستطيع تشرح؟ من يستطيع تشرح؟ دعاء كيف تشعر؟ لأن
+
+501
+00:45:12,460 --> 00:45:21,600
+.. نعم شعورك مقتصر ليس مستمر ، حسنًا أنا أسأل عن
+
+502
+00:45:21,600 --> 00:45:22,260
+شعورك
+
+503
+00:45:24,670 --> 00:45:30,250
+How do you feel about the problem in Egypt? okay
+
+504
+00:45:30,250 --> 00:45:33,590
+how do you feel about these people for example
+
+505
+00:45:33,590 --> 00:45:36,950
+though it can also be temporary the problem in
+
+506
+00:45:36,950 --> 00:45:41,290
+Egypt but it takes longer action okay so how are
+
+507
+00:45:41,290 --> 00:45:45,190
+you feeling today feeling is changeable okay go on
+
+508
+00:45:45,190 --> 00:45:50,270
+let's back again give me more different more about
+
+509
+00:45:50,270 --> 00:45:52,570
+what we said today yes please
+
+510
+00:45:59,930 --> 00:46:04,230
+Okay thank you very much good thank you yes please
+
+511
+00:46:04,230 --> 00:46:09,810
+okay
+
+512
+00:46:09,810 --> 00:46:15,490
+thank
+
+513
+00:46:15,490 --> 00:46:17,350
+you very much thank you yes please
+
+514
+00:46:32,220 --> 00:46:35,440
+Okay, so general facts for example, general
+
+515
+00:46:35,440 --> 00:46:38,080
+things, things in general, we use the present
+
+516
+00:46:38,080 --> 00:46:40,280
+simple. Thank you very much. Good. Yes, please,
+
+517
+00:46:40,360 --> 00:46:44,800
+Lama. We can use some of the state parts when we
+
+518
+00:46:44,800 --> 00:46:51,420
+talk about short periods.in april when we talk
+
+519
+00:46:51,420 --> 00:46:55,140
+about a short period okay thank you very much
+
+520
+00:46:55,140 --> 00:46:58,400
+about a short period this means again we refer to
+
+521
+00:46:58,400 --> 00:47:02,580
+what to permanent to temporary actions temporary
+
+522
+00:47:02,580 --> 00:47:08,860
+actions thank you very much yes please very
+
+523
+00:47:08,860 --> 00:47:12,020
+good this you did not mention when we make
+
+524
+00:47:12,020 --> 00:47:15,360
+summaries book reviews and film reviews thank you
+
+525
+00:47:15,360 --> 00:47:16,800
+good yes please Suzanne
+
+526
+00:47:22,680 --> 00:47:29,500
+very good thank you very much yeah okay
+
+527
+00:47:29,500 --> 00:47:36,300
+habits thank you very much good yes sometimes they
+
+528
+00:47:36,300 --> 00:47:39,770
+do thank you very muchthey have other meanings
+
+529
+00:47:39,770 --> 00:47:46,910
+thank you that's wonderful yes please okay
+
+530
+00:47:46,910 --> 00:47:56,250
+thank
+
+531
+00:47:56,250 --> 00:47:58,430
+you very much that's wonderful okay thank you very
+
+532
+00:47:58,430 --> 00:47:58,730
+much
+
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/Gx_fPJt0mzM_postprocess.srt b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/Gx_fPJt0mzM_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..4634b07794a02e3b3c951f4a98009b0e88ad15ea
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/Gx_fPJt0mzM_postprocess.srt
@@ -0,0 +1,1928 @@
+1
+00:00:20,600 --> 00:00:27,440
+Good morning to you all how are you thank you I'm
+
+2
+00:00:27,440 --> 00:00:35,780
+fine khadija how are you fine when did you come to
+
+3
+00:00:35,780 --> 00:00:44,000
+the university today at seven forty five good when
+
+4
+00:00:44,000 --> 00:00:48,420
+are you leaving I
+
+5
+00:00:48,420 --> 00:00:55,580
+leftwhen are you leaving the university today I'm
+
+6
+00:00:55,580 --> 00:01:01,760
+leaving at 7 okay I'm leaving you are leaving at
+
+7
+00:01:01,760 --> 00:01:04,920
+twelve at one and so on good thank you very much
+
+8
+00:01:04,920 --> 00:01:08,280
+I'm leaving at one when are you leaving the
+
+9
+00:01:08,280 --> 00:01:13,720
+university today at
+
+10
+00:01:13,720 --> 00:01:20,230
+twelve thank you I'm leaving at twelve nowنحن
+
+11
+00:01:20,230 --> 00:01:25,330
+نتكلم عن ماذا؟ at one، she is leaving at one، you
+
+12
+00:01:25,330 --> 00:01:29,890
+are leaving in the future، okay؟ مصدر ما استخدمناه
+
+13
+00:01:29,890 --> 00:01:34,450
+لتعريف المستقبل؟ present progressive، شكرا،
+
+14
+00:01:34,450 --> 00:01:39,890
+present progressive، الأن عندما نتكلم عن جهتنا أو
+
+15
+00:01:39,890 --> 00:01:47,250
+رحلتنا إلى المدرسةنحن مرتبطين لأحداث محددة، حسنًا؟
+
+16
+00:01:47,250 --> 00:01:53,650
+تأتي باعتبارك، لديك بعض الدراسات، الدراسات تبدأ في
+
+17
+00:01:53,650 --> 00:02:00,130
+وقت محدد و تنتهي في وقت محدد، لذا دراساتك مرتبطة
+
+18
+00:02:00,130 --> 00:02:04,830
+بطريقة محددة التي تجعلك تأتي في وقت محدد و تغادر
+
+19
+00:02:04,830 --> 00:02:14,060
+في وقت محدد، أخبرني ماذا ستفعل اليوم؟ماذا ستفعل
+
+20
+00:02:14,060 --> 00:02:23,720
+اليوم؟ انا ذاهب للشواء انا ذاهب لشواء انا ذاهب
+
+21
+00:02:23,720 --> 00:02:27,200
+لشواء انا ذاهب لشواء انا ذاهب لشواء انا ذاهب لشواء
+
+22
+00:02:27,200 --> 00:02:30,660
+انا ذاهب لشواء انا ذاهب لشواء انا ذاهب لشواء انا
+
+23
+00:02:30,660 --> 00:02:30,920
+ذاهب لشواء انا ذاهب لشواء انا ذاهب لشواء انا ذاهب
+
+24
+00:02:30,920 --> 00:02:33,880
+لشواء انا ذاهب لشواء انا ذاهب لشواء انا ذاهب لشواء
+
+25
+00:02:33,880 --> 00:02:37,520
+انا ذاهب لشواء انا ذاهب لشواء انا ذاهب لشواء انا
+
+26
+00:02:37,520 --> 00:02:40,180
+ذاهب لشواء انا ذاهب لشواء انا ذاهب لشواء انا ذاهب
+
+27
+00:02:40,180 --> 00:02:46,360
+لشواء انا ذاهب لشالأن، هل يمكنك أن تقرأ المثال،
+
+28
+00:02:46,360 --> 00:02:51,020
+أرجوك؟
+
+29
+00:02:51,020 --> 00:02:55,560
+عزيزتي، زوجتي لديها مقابلة مع دكتور، و هي تراه
+
+30
+00:02:55,560 --> 00:03:00,780
+دكتور نهر الماضي شكرا، هي تراه الدكتور للمقابلة
+
+31
+00:03:00,780 --> 00:03:03,080
+للمقابلة المقابلة المقابلة المقابلة المقابلة
+
+32
+00:03:03,080 --> 00:03:04,220
+المقابلة المقابلة المقابلة المقابلة المقابلة
+
+33
+00:03:04,220 --> 00:03:06,520
+المقابلة المقابلة المقابلة المقابلة المقابلة
+
+34
+00:03:06,520 --> 00:03:07,260
+المقابلة المقابلة المقابلة المقابلة المقابلة
+
+35
+00:03:07,260 --> 00:03:09,480
+المقابلة المقابلة المقابلة المقابلة المقابلة
+
+36
+00:03:09,480 --> 00:03:10,200
+المقابلة المقابلة المقابلة المقابلة المقابلة
+
+37
+00:03:10,200 --> 00:03:13,240
+المقابلة المقابمع المستقبل، إنها تتعرف على
+
+38
+00:03:13,240 --> 00:03:20,400
+المستقبل. كيف .. كيف .. كيف ندرس المستقبل؟ بـ
+
+39
+00:03:20,400 --> 00:03:26,560
+present؟ حسنًا، بـ progressive. عندما أقول إن ما
+
+40
+00:03:26,560 --> 00:03:31,760
+أراه، ما أقابله، يزوره، هذا هو present
+
+41
+00:03:31,760 --> 00:03:37,060
+progressive. لكن هل أستطيع فهمه؟ كيف أستطيع فهمه؟
+
+42
+00:03:38,220 --> 00:03:41,500
+its reference does it refer to the future or to
+
+43
+00:03:41,500 --> 00:03:46,300
+the present how did I know by okay next you next
+
+44
+00:03:46,300 --> 00:03:50,940
+next Tuesday I have some words that refer to the
+
+45
+00:03:50,940 --> 00:03:56,100
+time and they help me to know whether it is it
+
+46
+00:03:56,100 --> 00:03:59,880
+talks about the present or the future read the
+
+47
+00:03:59,880 --> 00:04:02,240
+other one please اسمه the other sentence
+
+48
+00:04:07,250 --> 00:04:12,090
+Thank you he is leaving at noon tomorrow tomorrow
+
+49
+00:04:12,090 --> 00:04:15,070
+this is the future again it is used to express
+
+50
+00:04:15,070 --> 00:04:21,050
+what okay present progressive expressed by the
+
+51
+00:04:21,050 --> 00:04:23,770
+future thank you read the other example please
+
+52
+00:04:23,770 --> 00:04:27,110
+okay
+
+53
+00:04:27,110 --> 00:04:31,090
+after lunch after lunch I am meeting a friend of
+
+54
+00:04:31,090 --> 00:04:35,930
+mine and we are going shopping would you likeThank
+
+55
+00:04:35,930 --> 00:04:38,930
+you. We are going shopping. I'm visiting my
+
+56
+00:04:38,930 --> 00:04:44,150
+sister. Okay. So again, give me other situations.
+
+57
+00:04:44,310 --> 00:04:47,130
+Use the present progressive to express the future.
+
+58
+00:04:47,630 --> 00:04:54,790
+Go on. Talk about yourself. Yeah. Thank you. Good.
+
+59
+00:05:00,120 --> 00:05:02,320
+Okay this is right but we want the present
+
+60
+00:05:02,320 --> 00:05:05,340
+progressive this is good it expresses the future
+
+61
+00:05:05,340 --> 00:05:09,920
+I'm writing my assignment at twelve thank you very
+
+62
+00:05:09,920 --> 00:05:15,820
+much good when are you having lunch today when
+
+63
+00:05:15,820 --> 00:05:20,980
+are you having lunch today at one I'm having lunch
+
+64
+00:05:20,980 --> 00:05:25,380
+at one okay I'm going shopping at three I'm
+
+65
+00:05:25,380 --> 00:05:28,440
+visiting my sister at four and so on
+
+66
+00:05:32,050 --> 00:05:37,110
+الان كما قلنا ال present progressive يمكن ان يكون
+
+67
+00:05:37,110 --> 00:05:41,830
+استخدامه لتظهر المستقبل إذا كنا نتحدث عن حدث مخطط
+
+68
+00:05:41,830 --> 00:05:49,410
+أو اهتمام محدد اهتمام محدد اهتمام مخصص اهتمام
+
+69
+00:05:49,410 --> 00:05:50,690
+اهتمام اهتمام اهتمام اهتمام اهتمام اهتمام اهتمام
+
+70
+00:05:50,690 --> 00:05:51,710
+اهتمام اهتمام اهتمام اهتمام اهتمام اهتمام اهتمام
+
+71
+00:05:51,710 --> 00:05:51,830
+اهتمام اهتمام اهتمام اهتمام اهتمام اهتمام اهتمام
+
+72
+00:05:51,830 --> 00:05:52,370
+اهتمام اهتمام اهتمام اهتمام اهتمام اهتمام اهتمام
+
+73
+00:05:52,370 --> 00:05:56,890
+اهتمام اهتمام اهتمام
+
+74
+00:06:04,730 --> 00:06:14,610
+الأن مرة أخرى إذا كنت تنظر إلى هذا الفعل رمضان
+
+75
+00:06:14,610 --> 00:06:20,570
+رمضان
+
+76
+00:06:20,570 --> 00:06:24,510
+هل نستطيع أن نستخدم رمضان في المتقدم لتظهر
+
+77
+00:06:24,510 --> 00:06:30,830
+المستقبل؟الان استمع، اقول ان انا انام، يمكنك تجهيز
+
+78
+00:06:30,830 --> 00:06:35,390
+الطعام، أليس كذلك؟ انا أزور، يمكنك تجهيز التجهيز،
+
+79
+00:06:35,390 --> 00:06:41,330
+يمكنك تخطيط الأحداث، انا أدرس، انا أبقى في المنزل
+
+80
+00:06:41,330 --> 00:06:46,780
+الليلة، لكن ماذا عن الشمس؟هل لدينا أي شيء يتعلق
+
+81
+00:06:46,780 --> 00:06:51,500
+بالتوضيح للغياب أو التخطيط للغياب؟ لا لذلك هل
+
+82
+00:06:51,500 --> 00:06:56,620
+نستخدمه في الـ progressive لتظهر المستقبل؟ لا مع
+
+83
+00:06:56,620 --> 00:06:59,180
+بعض الفعاليه مع الغياب لا نستطيع استخدام هذه
+
+84
+00:06:59,180 --> 00:07:02,900
+الفعالية لا نستطيع استخدامها لتظهرها ، لذلك إذا
+
+85
+00:07:02,900 --> 00:07:06,840
+قال شخص ما أنه يتغيب يجب أن يكون عند ما؟ الآن في
+
+86
+00:07:06,840 --> 00:07:10,580
+هذا الوقت في هذا الوقت يجب أن يتغيب في الوقت
+
+87
+00:07:10,580 --> 00:07:10,960
+الحاضر
+
+88
+00:07:16,790 --> 00:07:28,590
+yeah look at this sentence read it please okay
+
+89
+00:07:28,590 --> 00:07:33,490
+thank you it is not a planned event okay we cannot
+
+90
+00:07:33,490 --> 00:07:36,690
+plan it we cannot plan it yes go on complete
+
+91
+00:07:45,410 --> 00:07:56,210
+Okay thank you now when I say I'm visiting my
+
+92
+00:07:56,210 --> 00:08:01,750
+sister tomorrow
+
+93
+00:08:01,750 --> 00:08:11,190
+now I'm visiting how did we know that this tense
+
+94
+00:08:11,190 --> 00:08:16,990
+the progressive expresses the future yeahtomorrow
+
+95
+00:08:16,990 --> 00:08:22,610
+هذا الكلمة تشير إلى ما تشير إلى المستقبل حسنا؟
+
+96
+00:08:22,610 --> 00:08:27,450
+لذلك الآن عندما أخبرك ان انتظر انهم يلعبوا كتابة
+
+97
+00:08:27,450 --> 00:08:30,070
+كتابة ان انتظر ان انتظر ان انتظر ان انتظر ان انتظر
+
+98
+00:08:30,070 --> 00:08:33,190
+ان انتظر ان انتظر ان انتظر ان انتظر ان انتظر ان
+
+99
+00:08:33,190 --> 00:08:34,490
+انتظر ان انتظر ان انتظر ان انتظر ان انتظر ان انتظر
+
+100
+00:08:34,490 --> 00:08:36,250
+ان انتظر ان انتظر ان انتظر ان انتظر ان انتظر ان
+
+101
+00:08:36,250 --> 00:08:36,630
+انتظر ان انتظر ان انتظر ان انتظر ان انتظر ان انتظر
+
+102
+00:08:36,630 --> 00:08:44,150
+انتظر ان
+
+103
+00:08:44,150 --> 00:08:56,820
+انتظفي المستقبل حسناً
+
+104
+00:08:56,820 --> 00:09:03,100
+إذا ذهبت إلى الكتابة أحيانًا تخيل أنك وصلت خلال
+
+105
+00:09:03,100 --> 00:09:07,140
+اللحظة إلى الكتابة في السبت و تقول لهم أريد أن
+
+106
+00:09:07,140 --> 00:09:15,340
+أبقى حتى العشرة يقولون أننا نغلق في السبتwe close
+
+107
+00:09:15,340 --> 00:09:22,960
+at eight okay she comes from rafah the bus from
+
+108
+00:09:22,960 --> 00:09:32,900
+rafah to gaza okay leaves at seven okay you want
+
+109
+00:09:32,900 --> 00:09:37,160
+toreceive your brother in the airport you are
+
+110
+00:09:37,160 --> 00:09:41,940
+waiting you knew that the plane from dubai for
+
+111
+00:09:41,940 --> 00:09:48,220
+example arrives at ten tonight arrives at ten okay
+
+112
+00:09:48,220 --> 00:09:51,980
+now arrives leaves
+
+113
+00:09:54,050 --> 00:10:00,110
+هذا ماذا؟ سمبل ولكنه مستخدم لتعبير عن ماذا؟
+
+114
+00:10:00,110 --> 00:10:04,950
+المستقبل، مستخدم لتعبير عن المستقبل أحيانًا إذا
+
+115
+00:10:04,950 --> 00:10:10,450
+أردنا نتحدث عن طائرات، عن طرق، عن أشياء مثل ذلك،
+
+116
+00:10:10,450 --> 00:10:16,050
+عن مؤسسات، حسنًا، مؤسسة، كتابة مفتوح في وقت معين
+
+117
+00:10:16,050 --> 00:10:20,750
+ومغلق في وقت معين، صحيح؟ لذلك عندما نتحدث عنها،
+
+118
+00:10:20,750 --> 00:10:26,570
+الأشياء التي تتطور مثل ذلكin the future we use the
+
+119
+00:10:26,570 --> 00:10:30,650
+present simple to express the future read please
+
+120
+00:10:30,650 --> 00:10:42,810
+this example yes read okay
+
+121
+00:10:42,810 --> 00:10:45,030
+opens
+
+122
+00:10:46,020 --> 00:10:49,380
+at ten o'clock tomorrow morning lock opens this is
+
+123
+00:10:49,380 --> 00:10:53,780
+present simple and we are talking about the future
+
+124
+00:10:53,780 --> 00:10:59,040
+go on please classesالدراسات تبدأ في الأسبوع
+
+125
+00:10:59,040 --> 00:11:04,380
+القادم، وانت الآن في ميلاد الشمس، وانت تقول
+
+126
+00:11:04,380 --> 00:11:10,240
+ما؟ دراسات تبدأ، وانت تقول ما؟ دراسات تبدأ، وانت
+
+127
+00:11:10,240 --> 00:11:13,560
+ما؟ دراسات تبدأ، وانت تقول ما؟ دراسات تبدأ، وانت
+
+128
+00:11:13,560 --> 00:11:18,420
+تقول ما؟ دراسات تبدأ، وانت تقول ما؟ دراسات تبدأ
+
+129
+00:11:23,590 --> 00:11:31,470
+الطيب يصل والطيب يترك الطيب يترك
+
+130
+00:11:31,470 --> 00:11:33,730
+الطيب يترك الطيب يترك طيب طيب طيب طيب طيب طيب طيب
+
+131
+00:11:33,730 --> 00:11:34,710
+طيب طيب طيب طيب طيب طيب طيب طيب طيب طيب طيب طيب
+
+132
+00:11:34,710 --> 00:11:34,930
+طيب طيب طيب طيب طيب طيب طيب طيب طيب طيب طيب طيب
+
+133
+00:11:34,930 --> 00:11:34,950
+طيب طيب طيب طيب طيب طيب طيب طيب طيب طيب طيب طيب
+
+134
+00:11:34,950 --> 00:11:38,490
+طيب طيب طيب طيب طيب
+
+135
+00:11:38,490 --> 00:11:46,150
+طيب طيب طيب طيب
+
+136
+00:11:46,150 --> 00:11:51,960
+طNow, yes مروة. The simple present can also be
+
+137
+00:11:51,960 --> 00:11:54,220
+used to express future time in a sentence
+
+138
+00:11:54,220 --> 00:11:57,280
+concerning even our own definite schedule or
+
+139
+00:11:57,280 --> 00:12:01,660
+timetable. This is definite, fixed, okay. Yeah, go
+
+140
+00:12:01,660 --> 00:12:05,060
+on. These sentences usually contain future-time
+
+141
+00:12:05,060 --> 00:12:09,090
+words. Future-time wordswhen I say it opens
+
+142
+00:12:09,090 --> 00:12:13,750
+tomorrow morning okay it arrives at it arrives
+
+143
+00:12:13,750 --> 00:12:18,350
+tonight okay you should use words like that okay
+
+144
+00:12:18,350 --> 00:12:22,510
+to help the reader understand that you are talking
+
+145
+00:12:22,510 --> 00:12:26,570
+about the future okay go on only few words are
+
+146
+00:12:26,570 --> 00:12:30,530
+used in this way for example open, close, begin,
+
+147
+00:12:30,970 --> 00:12:33,850
+end, start, finish, arrive, leave, come, return
+
+148
+00:12:34,090 --> 00:12:38,270
+شكرا لك لذلك لا يمكننا أن نستخدم كل الكلمات في إسم
+
+149
+00:12:38,270 --> 00:12:49,570
+الحجر لتوصيل المستقبل الآن دعاء
+
+150
+00:12:49,570 --> 00:13:00,130
+متى ستغادر المدرسة اليوم؟ مجددا أخبرني متى متى
+
+151
+00:13:00,130 --> 00:13:11,270
+ستغادر؟ متى؟ نعمtwo okay now yeah now we say she
+
+152
+00:13:11,270 --> 00:13:16,290
+is leaving at what at one okay she's leaving at
+
+153
+00:13:16,290 --> 00:13:22,470
+one at two she
+
+154
+00:13:22,470 --> 00:13:31,390
+will be having lunch okay
+
+155
+00:13:32,630 --> 00:13:36,210
+at two she will be having lunch what will you be
+
+156
+00:13:36,210 --> 00:13:40,190
+doing at two thirty at two thirty what will you be
+
+157
+00:13:40,190 --> 00:13:45,010
+doing yes she
+
+158
+00:13:45,010 --> 00:13:51,970
+will be okay
+
+159
+00:13:51,970 --> 00:14:02,440
+sleeping she will be sleeping okay at fourshe will
+
+160
+00:14:02,440 --> 00:14:11,400
+be studying what
+
+161
+00:14:11,400 --> 00:14:15,720
+will you be doing at 10 tonight? I will be
+
+162
+00:14:15,720 --> 00:14:21,800
+watching TV what will you be doing tomorrow at
+
+163
+00:14:21,800 --> 00:14:22,340
+this time?
+
+164
+00:14:27,040 --> 00:14:30,560
+I will be studying good what will you be doing
+
+165
+00:14:30,560 --> 00:14:37,920
+tomorrow evening yes I will be sleeping good thank
+
+166
+00:14:37,920 --> 00:14:46,360
+you what will you be doing at ten today
+
+167
+00:14:46,360 --> 00:14:47,560
+at ten in the morning
+
+168
+00:14:52,640 --> 00:14:56,480
+I will be studying good thank you and what about
+
+169
+00:14:56,480 --> 00:15:02,340
+you what will you be doing at 10 I will be having
+
+170
+00:15:02,340 --> 00:15:09,040
+breakfast okay I will be having breakfast now a
+
+171
+00:15:09,040 --> 00:15:14,360
+friend of mine wanted to visit me at 10 tonight I
+
+172
+00:15:14,360 --> 00:15:19,420
+told him sorry don't come at 10because I will be
+
+173
+00:15:19,420 --> 00:15:24,840
+sleeping at ten okay I will be sleeping look two
+
+174
+00:15:24,840 --> 00:15:29,580
+thirty she will be sleeping she will be sleeping
+
+175
+00:15:29,580 --> 00:15:34,500
+now this is what this
+
+176
+00:15:34,500 --> 00:15:41,580
+is ten in the evening okay will be sleeping when
+
+177
+00:15:41,580 --> 00:15:45,650
+did the or when will the action startbefore ten
+
+178
+00:15:45,650 --> 00:15:49,470
+very good the action will start before ten will
+
+179
+00:15:49,470 --> 00:15:55,510
+the action continue after ten yes okay so will be
+
+180
+00:15:55,510 --> 00:16:00,730
+sleeping this action or this time will be in the
+
+181
+00:16:00,730 --> 00:16:05,060
+middle of the action okayit will be in the middle
+
+182
+00:16:05,060 --> 00:16:08,640
+of the action it means that the action starts
+
+183
+00:16:08,640 --> 00:16:14,180
+before and continues after okay what do we call
+
+184
+00:16:14,180 --> 00:16:17,560
+this tense will be studying will be sleeping yeah
+
+185
+00:16:17,560 --> 00:16:23,200
+future progressive thank you future progressive i
+
+186
+00:16:23,200 --> 00:16:30,340
+will be driving home at one what about you ياسمين
+
+187
+00:16:30,340 --> 00:16:36,250
+what will you be doing at oneI will be walking to
+
+188
+00:16:36,250 --> 00:16:42,330
+my home. Yes, tell me more about yourself. What
+
+189
+00:16:42,330 --> 00:16:46,190
+will you be doing in the future? Yes, what will
+
+190
+00:16:46,190 --> 00:16:52,310
+you be doing on Friday morning? I will be visiting
+
+191
+00:16:52,310 --> 00:16:55,770
+my uncle. Thank you. What will you be doing Friday
+
+192
+00:16:55,770 --> 00:16:56,350
+morning?
+
+193
+00:16:59,280 --> 00:17:02,040
+I will be sitting with my sister. Good thank you.
+
+194
+00:17:02,260 --> 00:17:04,700
+And what about you? What will you be doing Friday
+
+195
+00:17:04,700 --> 00:17:10,240
+morning? I will be studying English. Thank you. I
+
+196
+00:17:10,240 --> 00:17:15,660
+will be cleaning my house. Thank you very much. I
+
+197
+00:17:15,660 --> 00:17:19,060
+will be cleaning my house. Okay, would you please
+
+198
+00:17:19,060 --> 00:17:24,420
+read the example?I will begin to study at event
+
+199
+00:17:24,420 --> 00:17:29,320
+you will come at eight I will be studying when you
+
+200
+00:17:29,320 --> 00:17:35,440
+come okay thank you look I begin study I will
+
+201
+00:17:35,440 --> 00:17:41,000
+begin at seven you will come at eight I will be
+
+202
+00:17:41,000 --> 00:17:44,520
+studying when you come when will you start
+
+203
+00:17:44,520 --> 00:17:51,310
+studyingقبل ذلك و هل ستستمر بعد ذلك الوقت؟ نعم
+
+204
+00:17:51,310 --> 00:18:00,990
+بالطبع، نعم، أكمل، أرجوك شكرا،
+
+205
+00:18:00,990 --> 00:18:03,790
+سيكون في تقدم، عندما أقول at ten, I will be
+
+206
+00:18:03,790 --> 00:18:11,430
+sleeping الاختصار سيستمر، الاختصار سيكون في تقدم،
+
+207
+00:18:11,430 --> 00:18:12,710
+اتفقنا، اقرأ مثل الأخر
+
+208
+00:18:23,070 --> 00:18:27,570
+thank you we can express the future by using what
+
+209
+00:18:27,570 --> 00:18:31,750
+going to I'm going to write well okay and you know
+
+210
+00:18:31,750 --> 00:18:38,390
+the difference between well and going to now
+
+211
+00:18:38,390 --> 00:18:42,770
+look
+
+212
+00:18:42,770 --> 00:18:47,140
+at this sentencewhen I say don't worry she will be
+
+213
+00:18:47,140 --> 00:18:53,460
+coming soon she will come soon she will be coming
+
+214
+00:18:53,460 --> 00:19:00,520
+soon we are talking about the future is there any
+
+215
+00:19:00,520 --> 00:19:04,180
+definite time mentioned in the future look at the
+
+216
+00:19:04,180 --> 00:19:11,220
+sentence soon okay soon it can be a minute and can
+
+217
+00:19:11,220 --> 00:19:16,210
+beأشهر يمكن أن تكون في يوم واحد وما إلى ذلك، ليس
+
+218
+00:19:16,210 --> 00:19:19,110
+مختلفاً، إنه مختلف من القول في الساعة السادسة، على
+
+219
+00:19:19,110 --> 00:19:22,390
+سبيل المثال، في الساعة السادسة، هذا وقت محدد ووقت
+
+220
+00:19:22,390 --> 00:19:28,080
+محدد. حسنًا، عندما تتكلم عنthe future about
+
+221
+00:19:28,080 --> 00:19:31,520
+indefinite time in the future you can use the
+
+222
+00:19:31,520 --> 00:19:35,800
+symbol future or the future progressive okay they
+
+223
+00:19:35,800 --> 00:19:41,320
+are the same but if you if you are talking about a
+
+224
+00:19:41,320 --> 00:19:46,100
+definite time in the future okay you can use what
+
+225
+00:19:46,100 --> 00:19:50,480
+the symbol future okay read please will you read
+
+226
+00:19:50,480 --> 00:19:54,880
+the first example go
+
+227
+00:19:54,880 --> 00:20:04,930
+onthank you very much complete please thank
+
+228
+00:20:04,930 --> 00:20:13,050
+you
+
+229
+00:20:13,050 --> 00:20:15,890
+very much okay so
+
+230
+00:20:17,510 --> 00:20:21,970
+في هذه الحالة لا وقت محدد يمكننا أن نستخدم المصطلح
+
+231
+00:20:21,970 --> 00:20:34,010
+future أو المصطلح progressive الآن دعونا
+
+232
+00:20:34,010 --> 00:20:37,190
+نتكلم عن الدعاء مرة أخرى
+
+233
+00:21:01,990 --> 00:21:08,790
+عشان دعاء يذهب للعشاء في السادسةwhen she goes to
+
+234
+00:21:08,790 --> 00:21:17,750
+bed she should have completed all her duties she
+
+235
+00:21:17,750 --> 00:21:25,470
+will
+
+236
+00:21:25,470 --> 00:21:36,870
+have written her homeworkShe will have written her
+
+237
+00:21:36,870 --> 00:21:41,390
+homework. She will have cleaned the house. She
+
+238
+00:21:41,390 --> 00:21:48,090
+will have watched TV. Tell me about yourself. When
+
+239
+00:21:48,090 --> 00:21:52,590
+you go to bed, what will you have done? What will
+
+240
+00:21:52,590 --> 00:21:54,170
+you have done when you go to bed?
+
+241
+00:21:58,120 --> 00:22:03,240
+سأقرأ بعض الأقصاد من القرآن الكريم. شكرا جزيلا.
+
+242
+00:22:03,560 --> 00:22:05,320
+نعم، ماذا ستفعل؟
+
+243
+00:22:11,470 --> 00:22:14,270
+I will have done my homework very good thank you
+
+244
+00:22:14,270 --> 00:22:17,230
+yes I will have brushed my teeth I will have
+
+245
+00:22:17,230 --> 00:22:20,410
+brushed my teeth very good now next week we are
+
+246
+00:22:20,410 --> 00:22:25,230
+having there is عيد right okay and you know people
+
+247
+00:22:25,230 --> 00:22:30,430
+especially ladies are so busy at homes okay now
+
+248
+00:22:30,430 --> 00:22:35,850
+the first day imagine it is Tuesday what will you
+
+249
+00:22:35,850 --> 00:22:42,110
+have doneعشان تيوزيديا صباحا الاشياء اللي يجب ان
+
+250
+00:22:42,110 --> 00:22:47,870
+تتمويلها قبلها نحن سنفعلها نفعلها نفعلها نفعلها
+
+251
+00:22:47,870 --> 00:22:49,130
+نفعلها نفعلها نفعلها نفعلها نفعلها نفعلها نفعلها
+
+252
+00:22:49,130 --> 00:22:49,910
+نفعلها نفعلها نفعلها نفعلها نفعلها نفعلها نفعلها
+
+253
+00:22:49,910 --> 00:22:50,070
+نفعلها نفعلها نفعلها نفعلها نفعلها نفعلها نفعلها
+
+254
+00:22:50,070 --> 00:22:55,590
+نفعلها نفعلها نفعلها
+
+255
+00:22:55,590 --> 00:23:00,330
+نفعلها نفعلها نفعلها نفعلها نفعلها نفعلها نفعلها
+
+256
+00:23:00,330 --> 00:23:00,510
+نفعلها نفعلها نفعلها نفعلها نفعلها نفعلها نفعلها
+
+257
+00:23:00,510 --> 00:23:03,250
+نفعلها نفعلها نفعلها نفعلها نفعلها
+
+258
+00:23:04,660 --> 00:23:07,860
+Okay, bought a new dress. Again, what will you
+
+259
+00:23:07,860 --> 00:23:12,440
+have done؟ Say it again. Good. I will have bought
+
+260
+00:23:12,440 --> 00:23:14,660
+a new dress. Thank you. And what about you, Noor?
+
+261
+00:23:16,760 --> 00:23:19,600
+Okay, will have bought some chocolates and sweets.
+
+262
+00:23:19,740 --> 00:23:23,380
+Good. Thank you. And what about you? Good. Thank
+
+263
+00:23:23,380 --> 00:23:29,360
+you very much. Yeah, go on. Yes, please. I will
+
+264
+00:23:29,360 --> 00:23:32,320
+have called my friends. Good. Yes, please. Go on.
+
+265
+00:23:32,360 --> 00:23:35,100
+What will you have done?yes you
+
+266
+00:23:41,820 --> 00:23:46,000
+Okay I will have eaten some chocolates okay thank
+
+267
+00:23:46,000 --> 00:23:49,100
+you very much okay now when I say I will have
+
+268
+00:23:49,100 --> 00:23:52,440
+eaten I will have cleaned I will have bought I
+
+269
+00:23:52,440 --> 00:23:56,620
+will have visited okay now we are talking about a
+
+270
+00:23:56,620 --> 00:24:01,540
+certain time in the future she will have written
+
+271
+00:24:01,540 --> 00:24:05,800
+her homework can you tell me when do we usually or
+
+272
+00:24:05,800 --> 00:24:10,650
+before when what do we call this tensehave will
+
+273
+00:24:10,650 --> 00:24:15,730
+have written what do we call it future perfect
+
+274
+00:24:15,730 --> 00:24:21,350
+thank you when do we use it okay in the future you
+
+275
+00:24:21,350 --> 00:24:24,770
+are right this is a clever answer but when exactly
+
+276
+00:24:24,770 --> 00:24:27,430
+in the future yeah thank you
+
+277
+00:24:33,290 --> 00:24:38,170
+عظيم، الآن عندما أقول في السادسة، هي ستكون مكتوبة،
+
+278
+00:24:38,170 --> 00:24:44,410
+هي ستكون مكتوبة، هذا يعني أن هذه المشروع، الكتابة
+
+279
+00:24:44,410 --> 00:24:49,310
+على سبيل المثال، سيتم إكماله قبل هذه الوقت، وهو
+
+280
+00:24:49,310 --> 00:24:55,290
+وقت مستقل، المشروع سيتم إكماله قبل هذه الوقت في
+
+281
+00:24:55,290 --> 00:24:55,890
+المستقبل
+
+282
+00:25:04,850 --> 00:25:09,690
+ماذا تقرأ؟ انا سأدرس في شهر يوليو و سأراك في شهر
+
+283
+00:25:09,690 --> 00:25:12,170
+يوليو و في ذلك الوقت انا سأدرس في شهر يوليو و انا
+
+284
+00:25:12,170 --> 00:25:15,070
+سأدرس في شهر يوليو و انا سأدرس في شهر يوليو و انا
+
+285
+00:25:15,070 --> 00:25:16,670
+سأدرس في شهر يوليو و انا سأدرس في شهر يوليو و انا
+
+286
+00:25:16,670 --> 00:25:19,650
+سأدرس في شهر يوليو و انا سأدرس في شهر يوليو و انا
+
+287
+00:25:19,650 --> 00:25:20,970
+سأدرس في شهر يوليو و انا سأدرس في شهر يوليو و انا
+
+288
+00:25:20,970 --> 00:25:24,830
+سأدرس في شهر يوليو و انا سأدرس في شهر يوليو و انا
+
+289
+00:25:24,830 --> 00:25:27,170
+سأد
+
+290
+00:25:29,010 --> 00:25:34,350
+شكرًا لك قبل مرة أخرى أو عملية في المستقبل، هل
+
+291
+00:25:34,350 --> 00:25:39,990
+يمكنك أن تكتب قصة واحدة عن نفسك باستخدام future
+
+292
+00:25:39,990 --> 00:25:43,530
+perfect؟ حسنًا، سأعطيك ثلاثة ثانوية ثانوية فقط،
+
+293
+00:25:43,530 --> 00:25:48,850
+قصة بسيطة جدًا، كتبها، فتفكر في قصة، سأخذها منك،
+
+294
+00:25:48,850 --> 00:25:53,190
+وسأطلب من خمس طلاب، اذهب، كتب قصة واحدة عن نفسك
+
+295
+00:26:38,940 --> 00:26:43,000
+Okay, who can give me .. yeah Marwa By the time I
+
+296
+00:26:43,000 --> 00:26:45,240
+come home today, I will have finished my lecture
+
+297
+00:26:45,240 --> 00:26:48,540
+Very good, I will have By the time she returns
+
+298
+00:26:48,540 --> 00:26:52,020
+home, she will have finished her lectures No more
+
+299
+00:26:52,020 --> 00:26:55,570
+lectures, this is a good sentence, yeahwhen I
+
+300
+00:26:55,570 --> 00:26:58,930
+graduate from the university I will be where؟
+
+301
+00:26:58,930 --> 00:27:06,910
+thank you when okay so you say when I in 2017 for
+
+302
+00:27:06,910 --> 00:27:11,290
+example I will have graduated I will have
+
+303
+00:27:11,290 --> 00:27:13,930
+graduated or when I get a job I will have
+
+304
+00:27:13,930 --> 00:27:16,330
+graduated thank you good yes please
+
+305
+00:27:19,840 --> 00:27:24,380
+ممتاز جيد جدا قبل أن أذهب للجلوس سوف أفعل كل عملي
+
+306
+00:27:24,380 --> 00:27:30,960
+شكرا لك نعم أرجوك حسنا
+
+307
+00:27:30,960 --> 00:27:38,120
+عندما أرحل سوف أترك .. سوف أساعد أمي شكرا جدا جيد
+
+308
+00:27:38,120 --> 00:27:46,300
+نعم
+
+309
+00:27:47,830 --> 00:27:53,750
+We have a future test, simple and progressive and
+
+310
+00:27:53,750 --> 00:27:59,490
+perfect. So why use the present progressive to
+
+311
+00:27:59,490 --> 00:28:02,880
+express about the future?Why? To use the present
+
+312
+00:28:02,880 --> 00:28:05,440
+progressive to express the future. You know, we
+
+313
+00:28:05,440 --> 00:28:10,920
+have different tenses. Each tense has a certain
+
+314
+00:28:10,920 --> 00:28:14,860
+function, let's say, has a certain meaning. Now I
+
+315
+00:28:14,860 --> 00:28:17,640
+want to talk about a definite time in the future
+
+316
+00:28:19,250 --> 00:28:22,210
+وقت محدد على سبيل المثال او اريت ان اتكلم عن
+
+317
+00:28:22,210 --> 00:28:26,790
+التوقع في المستقبل انا استخدم ماذا انا استخدم انا
+
+318
+00:28:26,790 --> 00:28:28,590
+استخدم انا استخدم انا استخدم انا استخدم انا استخدم
+
+319
+00:28:28,590 --> 00:28:29,810
+انا استخدم انا استخدم انا استخدم انا استخدم انا
+
+320
+00:28:29,810 --> 00:28:29,930
+انا استخدم انا استخدم انا استخدم انا استخدم انا
+
+321
+00:28:29,930 --> 00:28:30,330
+استخدم انا استخدم انا استخدم انا استخدم انا استخدم
+
+322
+00:28:30,330 --> 00:28:31,290
+انا استخدم انا استخدم انا استخدم انا استخدم انا
+
+323
+00:28:31,290 --> 00:28:32,910
+استخدم انا استخدم انا استخدم انا استخدم انا استخدم
+
+324
+00:28:32,910 --> 00:28:36,150
+انا استخدم انا استخدم انا
+
+325
+00:28:36,150 --> 00:28:45,010
+استخدم انا
+
+326
+00:28:45,010 --> 00:28:45,410
+استخ
+
+327
+00:28:48,590 --> 00:28:53,270
+وإذا أردت أن أتحدث عن استخدام المستقبل المتقدم،
+
+328
+00:28:53,270 --> 00:28:58,490
+فهو يحتوي على معنى أخر، فالعمل أو هذا النقطة التي
+
+329
+00:28:58,490 --> 00:29:03,350
+أتحدث عنها في المستقبل سيكون في أعضاء العمل، ماذا
+
+330
+00:29:03,350 --> 00:29:08,110
+عن المستقبل المتقدم؟ مستقبل المستقبل المتقدم لديه
+
+331
+00:29:08,110 --> 00:29:12,710
+استخدام مختلف، حسنًا، هناك بعض التجارب، حسنًا كما
+
+332
+00:29:12,710 --> 00:29:20,020
+قلت لك الآن عندما تغادر المدرسةلا تترك المدرسة حتى
+
+333
+00:29:20,020 --> 00:29:24,620
+لو انك انتهيت من دراساتك، حسنًا لديك بعض الدراسات،
+
+334
+00:29:24,620 --> 00:29:29,340
+الأشياء مرتبطة مع بعضك، لذلك تستخدم الـ perfect،
+
+335
+00:29:29,340 --> 00:29:35,540
+تستخدم ال progressive لتوصيل هذا الشيءespecially
+
+336
+00:29:35,540 --> 00:29:39,480
+you know when we are talking about a future event
+
+337
+00:29:39,480 --> 00:29:42,320
+and there are arrangements we use this tense so
+
+338
+00:29:42,320 --> 00:29:46,420
+again each tense expresses a certain meaning
+
+339
+00:29:46,420 --> 00:29:50,240
+conveys a certain message to the reader or to the
+
+340
+00:29:50,240 --> 00:29:54,380
+listener okay sometimes they meet in certain
+
+341
+00:29:54,380 --> 00:29:59,900
+points sometimes but usually it's clear that each
+
+342
+00:29:59,900 --> 00:30:10,370
+one has its own meaning okayالأن نور
+
+343
+00:30:10,370 --> 00:30:21,310
+لديها أخت صغيرة نور لديها أخت صغيرة عندما تدرس في
+
+344
+00:30:21,310 --> 00:30:26,110
+المنزل أختها تصرخ
+
+345
+00:30:26,110 --> 00:30:29,530
+فأمها
+
+346
+00:30:29,530 --> 00:30:33,270
+ستساعدها
+
+347
+00:30:33,270 --> 00:30:39,510
+كيف؟by putting her sister to sleep the little
+
+348
+00:30:39,510 --> 00:30:46,330
+sister the sister now the little sister okay went
+
+349
+00:30:46,330 --> 00:30:54,150
+will go to bed at seven okay the little baby will
+
+350
+00:30:54,150 --> 00:31:03,130
+go to bed at seven and at from seven to nineمن
+
+351
+00:31:03,130 --> 00:31:05,990
+الساعة السادسة إلى السادسة إذا قلنا هذا فالطفل
+
+352
+00:31:05,990 --> 00:31:10,110
+سيذهب إلى الساعة السادسة ويبدأ حتى الساعة السادسة
+
+353
+00:31:10,110 --> 00:31:17,230
+طفل سيبقى
+
+354
+00:31:17,230 --> 00:31:21,390
+نائم
+
+355
+00:31:21,390 --> 00:31:26,710
+ل2
+
+356
+00:31:26,710 --> 00:31:33,430
+ساعات الأن اسمععندما أتكلم عن هذه اللحظة في
+
+357
+00:31:33,430 --> 00:31:39,250
+المستقبل، سنذهب للجلوس في الساعة السادسة، في
+
+358
+00:31:39,250 --> 00:31:45,710
+الساعة التاسعة، فالطفل سيبقى ينام. إذا كنت تتكلم
+
+359
+00:31:45,710 --> 00:31:50,950
+عن لحظة أخرى، عندما نذهب للجلوس في الساعة التاسعة،
+
+360
+00:31:50,950 --> 00:32:00,620
+فالطفل سيبقى ينام ل2 ساعات.الطفل سيكون منام ل2
+
+361
+00:32:00,620 --> 00:32:08,340
+ساعتين عندما اتقبلت المدرسة؟ اتقبلت المدرسة في
+
+362
+00:32:08,340 --> 00:32:15,620
+سبتمبر، صحيح؟ اتقبلت المدرسة في سبتمبر في أول
+
+363
+00:32:15,620 --> 00:32:20,380
+نوفمبر ستكون
+
+364
+00:32:24,200 --> 00:32:28,120
+Okay studying or coming to the university for two
+
+365
+00:32:28,120 --> 00:32:33,520
+months okay will
+
+366
+00:32:33,520 --> 00:32:39,480
+have will have been studying will have been coming
+
+367
+00:32:39,480 --> 00:32:44,740
+to the university okay yeah I have an example yes
+
+368
+00:32:44,740 --> 00:32:50,640
+go on before I run away from the university I
+
+369
+00:32:50,640 --> 00:32:55,480
+would have been studying for four yearsشكرا جزيلا
+
+370
+00:32:55,480 --> 00:33:02,900
+جدا جيد سوف أتدرس سوف أتدرس عندما جاءت لعبة نجوة
+
+371
+00:33:02,900 --> 00:33:11,100
+اليوم عندما جاءت لعبة نجوة اليوم عندما جاءت لعبة
+
+372
+00:33:11,100 --> 00:33:14,180
+نجوة اليوم عندما جاءت لعبة نجوة اليوم
+
+373
+00:33:20,230 --> 00:33:30,910
+ثلاثة ثلاثة حسنا ات ثلاثة ات ات ات ات ات ات ات ات
+
+374
+00:33:30,910 --> 00:33:32,750
+ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات
+
+375
+00:33:32,750 --> 00:33:34,570
+ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات
+
+376
+00:33:34,570 --> 00:33:37,270
+ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات
+
+377
+00:33:37,270 --> 00:33:37,310
+ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات
+
+378
+00:33:37,310 --> 00:33:39,630
+ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات
+
+379
+00:33:39,630 --> 00:33:48,090
+ات ات ات ات ات ات ات ات
+
+380
+00:33:48,090 --> 00:33:55,450
+اتwhen we talked about the future perfect when she
+
+381
+00:33:55,450 --> 00:34:01,230
+goes to bed she will have completed، she will have
+
+382
+00:34:01,230 --> 00:34:04,890
+done، she will have eaten، she will have written
+
+383
+00:34:06,600 --> 00:34:10,140
+Are we interested in the duration of the activity؟
+
+384
+00:34:10,140 --> 00:34:15,080
+No. Now, when I say for example, will have been
+
+385
+00:34:15,080 --> 00:34:19,440
+sitting, will have been studying, will have been
+
+386
+00:34:19,440 --> 00:34:24,960
+sleeping, what do you understand؟ماذا تفهمين؟ نعم
+
+387
+00:34:24,960 --> 00:34:29,900
+بفضل الله الامر يؤثر على المستقبل المستقبل، حسنا؟
+
+388
+00:34:29,900 --> 00:34:34,040
+المشروع سيحصل على مستقبل و هذا المستقبل، هذا
+
+389
+00:34:34,040 --> 00:34:39,240
+التقدم نحن نتحدث عن المستقبل مرة أخرى، حسنا؟ لذلك
+
+390
+00:34:39,240 --> 00:34:46,040
+المستقبل، المشروع سيحصل على مستقبل و سيستمر في
+
+391
+00:34:46,040 --> 00:34:53,140
+المستقبل قبل ما؟ انظرعندما قلنا ات فارتي لازم، ليس
+
+392
+00:34:53,140 --> 00:34:58,840
+ات فارتي، ليس ات فارتي، صح؟ لازم هذه الوقت هي وقت
+
+393
+00:34:58,840 --> 00:35:03,220
+المستقبل عندما نتحدث عن نوفمبر، نوفمبر هو أيضًا
+
+394
+00:35:03,220 --> 00:35:08,920
+وقت المستقبل، لذا فإن المشروع سيكون ماذا؟ في اتفاق
+
+395
+00:35:08,920 --> 00:35:15,860
+أو في دورة قبل هذا النقطة في الوقت، نعم، هل يمكنك
+
+396
+00:35:15,860 --> 00:35:17,740
+أن تفكر في أشخاص مثلها؟
+
+397
+00:35:28,360 --> 00:35:31,120
+الأن .. نعم .. نعم أرجوك تريدين أن تقومي بتصحيح
+
+398
+00:35:31,120 --> 00:35:33,920
+مثالي .. تريدين أن تقومي بتصحيح مثالي .. تريدين أن
+
+399
+00:35:33,920 --> 00:35:34,180
+تقومي بتصحيح مثالي .. تريدين أن تقومي بتصحيح مثالي
+
+400
+00:35:34,180 --> 00:35:34,280
+بتصحيح مثالي .. تريدين أن تقومي بتصحيح مثلي ..
+
+401
+00:35:34,280 --> 00:35:35,040
+تريدين أن تقومي بتصحيح مثلي .. تريدين أن تقومي
+
+402
+00:35:35,040 --> 00:35:39,780
+بتصحيح مثلي .. تريدين أن تقومي بتصحيح مثلي ..
+
+403
+00:35:39,780 --> 00:35:47,140
+تريدين أن تقومي بتصحيح مثلي .. تريدين
+
+404
+00:35:47,140 --> 00:35:50,180
+أن تقومي بتصحيح
+
+405
+00:36:07,550 --> 00:36:12,050
+in ten o'clock I will have been taking two
+
+406
+00:36:12,050 --> 00:36:16,930
+lectures very good I will have been taking I will
+
+407
+00:36:16,930 --> 00:36:18,770
+have been taking thank you
+
+408
+00:36:25,190 --> 00:36:39,370
+Okay could you please read the example Okay
+
+409
+00:36:39,370 --> 00:36:45,830
+you know we are talking about a future time so the
+
+410
+00:36:45,830 --> 00:36:52,770
+action will be what in progress read بسمةThe
+
+411
+00:36:52,770 --> 00:36:56,110
+future bed represents or emphasizes the duration
+
+412
+00:36:56,110 --> 00:36:59,750
+of an activity that will be in progress before
+
+413
+00:36:59,750 --> 00:37:03,650
+another time or even in the future thank you when
+
+414
+00:37:03,650 --> 00:37:08,800
+I go to bed when I graduateI will have been
+
+415
+00:37:08,800 --> 00:37:12,840
+studying for four years when I graduate graduate
+
+416
+00:37:12,840 --> 00:37:17,060
+this is a future event right I will have been
+
+417
+00:37:17,060 --> 00:37:22,420
+studying for four years now if I want to talk
+
+418
+00:37:22,420 --> 00:37:29,300
+about myself you remember when we talked about the
+
+419
+00:37:29,300 --> 00:37:31,280
+present perfect and the present perfect
+
+420
+00:37:31,280 --> 00:37:37,780
+progressiveممكن تقول انا عشت في غزا 10 سنة او انا
+
+421
+00:37:37,780 --> 00:37:42,700
+عشت اعيش في غزا 10 سنة عشت في غزا 10 سنة عشت في
+
+422
+00:37:42,700 --> 00:37:44,720
+غزا 10 سنة عشت في غزا 10 سنة عشت في غزا 10 سنة عشت
+
+423
+00:37:44,720 --> 00:37:44,740
+في غزا 10 سنة عشت في غزا 10 سنة عشت في غزا 10 سنة
+
+424
+00:37:44,740 --> 00:37:45,200
+عشت في غزا 10 سنة عشت في غزا 10 سنة عشت في غزا 10
+
+425
+00:37:45,200 --> 00:37:46,580
+سنة عشت في غزا 10 سنة عشت في غزا 10 سنة عشت في غزا
+
+426
+00:37:46,580 --> 00:37:47,900
+10 سنة عشت في غزا 10 سنة عشت في غزا 10 سنة عشت في
+
+427
+00:37:47,900 --> 00:38:01,740
+غزا 10 سنة عشت في غزا
+
+428
+00:38:01,740 --> 00:38:10,940
+10 سنة عnext by two thousand fourteen
+
+429
+00:38:10,940 --> 00:38:21,480
+okay or two thousand let's say fifteen I will have
+
+430
+00:38:21,480 --> 00:38:30,120
+taught English for thirty years or I will have
+
+431
+00:38:33,410 --> 00:38:39,410
+been teaching which one is right I will have
+
+432
+00:38:39,410 --> 00:38:42,970
+taught or I will have been teaching which one is
+
+433
+00:38:42,970 --> 00:38:45,790
+right ياسمين I think that the sentence have the
+
+434
+00:38:45,790 --> 00:38:48,730
+same meaning I think you are right thank you good
+
+435
+00:38:48,730 --> 00:38:54,830
+okay but what you want to add something maybe will
+
+436
+00:38:54,830 --> 00:39:00,800
+have been teaching beside the durationهذه طبيعة
+
+437
+00:39:00,800 --> 00:39:08,140
+المتقدس والمتقدس والمتقدس نفسه، واحد يؤكد الحركة
+
+438
+00:39:08,140 --> 00:39:12,380
+والآخر يؤكد النتائج، انت محقة، هذا عاملاً، انت
+
+439
+00:39:12,380 --> 00:39:13,060
+محقة، شكرا
+
+440
+00:39:25,570 --> 00:39:30,290
+هل يمكنك أن تقرأ؟ قم بقراءة المثال عندما يترى
+
+441
+00:39:30,290 --> 00:39:39,010
+البروفيسور جونز انه سيقوم بالتعليم ل45 سنة عندما
+
+442
+00:39:39,010 --> 00:39:46,530
+يترى عندما يترى عندما يترى عندما يترى سيقوم
+
+443
+00:39:46,530 --> 00:39:53,640
+بالتعليم نحن نتحدث عن ماذا؟ وقت المستقبلwe are
+
+444
+00:39:53,640 --> 00:39:59,900
+talking about a future time he will have taught or
+
+445
+00:39:59,900 --> 00:40:04,540
+he will have been teaching now the question is
+
+446
+00:40:04,540 --> 00:40:08,960
+that when professor jones retires this is a
+
+447
+00:40:08,960 --> 00:40:15,340
+present simple expresses what the future can i use
+
+448
+00:40:15,340 --> 00:40:19,400
+will here will retire because this expresses the
+
+449
+00:40:19,400 --> 00:40:20,460
+future
+
+450
+00:40:22,620 --> 00:40:26,800
+yes or no can I say when he retire when he will
+
+451
+00:40:26,800 --> 00:40:31,940
+retire next month can I use the future will yeah
+
+452
+00:40:31,940 --> 00:40:35,480
+very
+
+453
+00:40:35,480 --> 00:40:37,960
+good thank you very much this is a time clause
+
+454
+00:40:37,960 --> 00:40:42,920
+okay and we use the symbol to express what to
+
+455
+00:40:42,920 --> 00:40:46,560
+express the future good would you read the last
+
+456
+00:40:46,560 --> 00:40:47,380
+point please
+
+457
+00:41:02,020 --> 00:41:08,080
+Okay thank you okay may begin in the past how may
+
+458
+00:41:08,080 --> 00:41:13,360
+begin in the past I will have been teaching when
+
+459
+00:41:13,360 --> 00:41:19,310
+did I start teaching okayالان اخبرني ماذا تحدثنا
+
+460
+00:41:19,310 --> 00:41:27,770
+عنه اليوم دعونا نجمع المواصفات الرئيسية للدراسة
+
+461
+00:41:27,770 --> 00:41:32,250
+نعم أرجوك اذهبي اذهبي تفضلي
+
+462
+00:41:41,620 --> 00:41:47,560
+thank you good I will be studying at nine I will
+
+463
+00:41:47,560 --> 00:41:50,540
+be sleeping at nine the activity will be in
+
+464
+00:41:50,540 --> 00:41:53,920
+progress at this time in the future good go on
+
+465
+00:41:53,920 --> 00:42:03,400
+another point yes you with
+
+466
+00:42:03,400 --> 00:42:05,460
+raise your voice
+
+467
+00:42:15,160 --> 00:42:23,180
+شكرا شكرا نعم أرجوك طوال
+
+468
+00:42:23,180 --> 00:42:27,980
+المشروع سأكون مبقى حياة سأكون مبقى .. هي ستكون
+
+469
+00:42:27,980 --> 00:42:35,040
+مبقى نوم شكرا أجل أحيانا يعني أن المستقبل ممتاز
+
+470
+00:42:35,040 --> 00:42:38,720
+وممتاز وممتاز
+
+471
+00:42:41,540 --> 00:42:44,520
+with some verbs this is not always okay with some
+
+472
+00:42:44,520 --> 00:42:55,120
+verbs good you are right thank you yes please good
+
+473
+00:42:55,120 --> 00:43:00,820
+so when the future when we talk about okay
+
+474
+00:43:00,820 --> 00:43:05,820
+indefinite future we can use the simple future or
+
+475
+00:43:05,820 --> 00:43:11,840
+the future progressive thank you yeahI'm afraid
+
+476
+00:43:11,840 --> 00:43:14,820
+that it would be repeated before another time
+
+477
+00:43:14,820 --> 00:43:17,740
+thank you very much good yeah simple present can
+
+478
+00:43:17,740 --> 00:43:21,440
+be used to express future time in sentences that
+
+479
+00:43:21,440 --> 00:43:26,160
+have uneven punctuation thank you good yes please
+
+480
+00:43:26,160 --> 00:43:31,120
+in the present present we use to express a future
+
+481
+00:43:31,120 --> 00:43:37,100
+a future when we talk about a planned event or a
+
+482
+00:43:37,100 --> 00:43:40,180
+different eventThank you very much
+
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/Gx_fPJt0mzM_raw.json b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/Gx_fPJt0mzM_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..294e2f560dfab233e21d87c39b0071a76ee815c1
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/Gx_fPJt0mzM_raw.json
@@ -0,0 +1 @@
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0.95654296875}, {"start": 2599.24, "end": 2599.68, "word": " time", "probability": 0.64306640625}, {"start": 2599.68, "end": 2600.64, "word": " in", "probability": 0.56982421875}, {"start": 2600.64, "end": 2601.1, "word": " sentences", "probability": 0.8056640625}, {"start": 2601.1, "end": 2601.44, "word": " that", "probability": 0.94775390625}, {"start": 2601.44, "end": 2601.88, "word": " have", "probability": 0.93017578125}, {"start": 2601.88, "end": 2602.54, "word": " uneven", "probability": 0.35009765625}, {"start": 2602.54, "end": 2603.2, "word": " punctuation", "probability": 0.802734375}, {"start": 2603.2, "end": 2604.28, "word": " thank", "probability": 0.72900390625}, {"start": 2604.28, "end": 2604.54, "word": " you", "probability": 0.97021484375}, {"start": 2604.54, "end": 2605.24, "word": " good", "probability": 0.8740234375}, {"start": 2605.24, "end": 2605.64, "word": " yes", "probability": 0.94189453125}, {"start": 2605.64, "end": 2606.16, "word": " please", "probability": 0.7919921875}, {"start": 2606.16, "end": 2606.9, "word": " in", "probability": 0.298828125}, {"start": 2606.9, "end": 2607.0, "word": " the", "probability": 0.76171875}, {"start": 2607.0, "end": 2607.24, "word": " present", "probability": 0.89111328125}, {"start": 2607.24, "end": 2607.64, "word": " present", "probability": 0.197265625}, {"start": 2607.64, "end": 2608.04, "word": " we", "probability": 0.732421875}, {"start": 2608.04, "end": 2608.42, "word": " use", "probability": 0.806640625}, {"start": 2608.42, "end": 2609.14, "word": " to", "probability": 0.888671875}, {"start": 2609.14, "end": 2610.12, "word": " express", "probability": 0.70947265625}, {"start": 2610.12, "end": 2610.66, "word": " a", "probability": 0.9453125}, {"start": 2610.66, "end": 2611.12, "word": " future", "probability": 0.98193359375}, {"start": 2611.12, "end": 2611.68, "word": " a", "probability": 0.410888671875}, {"start": 2611.68, "end": 2612.2, "word": " future", "probability": 0.96533203125}, {"start": 2612.2, "end": 2613.18, "word": " when", "probability": 0.74169921875}, {"start": 2613.18, "end": 2613.62, "word": " we", "probability": 0.87841796875}, {"start": 2613.62, "end": 2613.82, "word": " talk", "probability": 0.8994140625}, {"start": 2613.82, "end": 2614.0, "word": " about", "probability": 0.5009765625}, {"start": 2614.0, "end": 2614.32, "word": " a", "probability": 0.68505859375}, {"start": 2614.32, "end": 2614.32, "word": " planned", "probability": 0.469482421875}, {"start": 2614.32, "end": 2616.46, "word": " event", "probability": 0.7802734375}, {"start": 2616.46, "end": 2616.92, "word": " or", "probability": 0.9423828125}, {"start": 2616.92, "end": 2617.1, "word": " a", "probability": 0.78759765625}, {"start": 2617.1, "end": 2617.42, "word": " different", "probability": 0.5263671875}, {"start": 2617.42, "end": 2617.88, "word": " event", "probability": 0.828125}], "temperature": 1.0}, {"id": 100, "seek": 262017, "start": 2619.22, "end": 2620.18, "text": "Thank you very much", "tokens": [51, 1641, 77, 74, 291, 588, 709], "avg_logprob": -0.4943847507238388, "compression_ratio": 0.7037037037037037, "no_speech_prob": 0.0, "words": [{"start": 2619.22, "end": 2619.58, "word": "Thank", "probability": 0.6662445068359375}, {"start": 2619.58, "end": 2619.68, "word": " you", "probability": 0.9482421875}, {"start": 2619.68, "end": 2619.84, "word": " very", "probability": 0.90283203125}, {"start": 2619.84, "end": 2620.18, "word": " much", "probability": 0.95068359375}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2623.52975, "duration_after_vad": 2420.6031249999933}
\ No newline at end of file
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/Gx_fPJt0mzM_raw.srt b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/Gx_fPJt0mzM_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..1f839d7994e479b7b0dc7c6bc6677cb5ab929ac6
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/Gx_fPJt0mzM_raw.srt
@@ -0,0 +1,1968 @@
+1
+00:00:20,600 --> 00:00:27,440
+Good morning to you all how are you thank you I'm
+
+2
+00:00:27,440 --> 00:00:35,780
+fine khadija how are you fine when did you come to
+
+3
+00:00:35,780 --> 00:00:44,000
+the university today at seven forty five good when
+
+4
+00:00:44,000 --> 00:00:48,420
+are you leaving I
+
+5
+00:00:48,420 --> 00:00:55,580
+leftwhen are you leaving the university today I'm
+
+6
+00:00:55,580 --> 00:01:01,760
+leaving at 7 okay I'm leaving you are leaving at
+
+7
+00:01:01,760 --> 00:01:04,920
+twelve at one and so on good thank you very much
+
+8
+00:01:04,920 --> 00:01:08,280
+I'm leaving at one when are you leaving the
+
+9
+00:01:08,280 --> 00:01:13,720
+university today at
+
+10
+00:01:13,720 --> 00:01:20,230
+twelve thank you I'm leaving at twelve nowنحن
+
+11
+00:01:20,230 --> 00:01:25,330
+نتكلم عن ماذا؟ at one، she is leaving at one، you
+
+12
+00:01:25,330 --> 00:01:29,890
+are leaving in the future، okay؟ مصدر ما استخدمناه
+
+13
+00:01:29,890 --> 00:01:34,450
+لتعريف المستقبل؟ present progressive، شكرا،
+
+14
+00:01:34,450 --> 00:01:39,890
+present progressive، الأن عندما نتكلم عن جهتنا أو
+
+15
+00:01:39,890 --> 00:01:47,250
+رحلتنا إلى المدرسةنحن مرتبطين لأحداث محددة، حسنًا؟
+
+16
+00:01:47,250 --> 00:01:53,650
+تأتي باعتبارك، لديك بعض الدراسات، الدراسات تبدأ في
+
+17
+00:01:53,650 --> 00:02:00,130
+وقت محدد و تنتهي في وقت محدد، لذا دراساتك مرتبطة
+
+18
+00:02:00,130 --> 00:02:04,830
+بطريقة محددة التي تجعلك تأتي في وقت محدد و تغادر
+
+19
+00:02:04,830 --> 00:02:14,060
+في وقت محدد، أخبرني ماذا ستفعل اليوم؟ماذا ستفعل
+
+20
+00:02:14,060 --> 00:02:23,720
+اليوم؟ انا ذاهب للشواء انا ذاهب لشواء انا ذاهب
+
+21
+00:02:23,720 --> 00:02:27,200
+لشواء انا ذاهب لشواء انا ذاهب لشواء انا ذاهب لشواء
+
+22
+00:02:27,200 --> 00:02:30,660
+انا ذاهب لشواء انا ذاهب لشواء انا ذاهب لشواء انا
+
+23
+00:02:30,660 --> 00:02:30,920
+ذاهب لشواء انا ذاهب لشواء انا ذاهب لشواء انا ذاهب
+
+24
+00:02:30,920 --> 00:02:33,880
+لشواء انا ذاهب لشواء انا ذاهب لشواء انا ذاهب لشواء
+
+25
+00:02:33,880 --> 00:02:37,520
+انا ذاهب لشواء انا ذاهب لشواء انا ذاهب لشواء انا
+
+26
+00:02:37,520 --> 00:02:40,180
+ذاهب لشواء انا ذاهب لشواء انا ذاهب لشواء انا ذاهب
+
+27
+00:02:40,180 --> 00:02:46,360
+لشواء انا ذاهب لشالأن، هل يمكنك أن تقرأ المثال،
+
+28
+00:02:46,360 --> 00:02:51,020
+أرجوك؟
+
+29
+00:02:51,020 --> 00:02:55,560
+عزيزتي، زوجتي لديها مقابلة مع دكتور، و هي تراه
+
+30
+00:02:55,560 --> 00:03:00,780
+دكتور نهر الماضي شكرا، هي تراه الدكتور للمقابلة
+
+31
+00:03:00,780 --> 00:03:03,080
+للمقابلة المقابلة المقابلة المقابلة المقابلة
+
+32
+00:03:03,080 --> 00:03:04,220
+المقابلة المقابلة المقابلة المقابلة المقابلة
+
+33
+00:03:04,220 --> 00:03:06,520
+المقابلة المقابلة المقابلة المقابلة المقابلة
+
+34
+00:03:06,520 --> 00:03:07,260
+المقابلة المقابلة المقابلة المقابلة المقابلة
+
+35
+00:03:07,260 --> 00:03:09,480
+المقابلة المقابلة المقابلة المقابلة المقابلة
+
+36
+00:03:09,480 --> 00:03:09,480
+المقابلة المقابلة المقابلة المقابلة المقابلة
+
+37
+00:03:09,480 --> 00:03:10,200
+المقابلة المقابلة المقابلة المقابلة المقابلة
+
+38
+00:03:10,200 --> 00:03:13,240
+المقابلة المقابمع المستقبل، إنها تتعرف على
+
+39
+00:03:13,240 --> 00:03:20,400
+المستقبل. كيف .. كيف .. كيف ندرس المستقبل؟ بـ
+
+40
+00:03:20,400 --> 00:03:26,560
+present؟ حسنًا، بـ progressive. عندما أقول إن ما
+
+41
+00:03:26,560 --> 00:03:31,760
+أراه، ما أقابله، يزوره، هذا هو present
+
+42
+00:03:31,760 --> 00:03:37,060
+progressive. لكن هل أستطيع فهمه؟ كيف أستطيع فهمه؟
+
+43
+00:03:38,220 --> 00:03:41,500
+its reference does it refer to the future or to
+
+44
+00:03:41,500 --> 00:03:46,300
+the present how did I know by okay next you next
+
+45
+00:03:46,300 --> 00:03:50,940
+next Tuesday I have some words that refer to the
+
+46
+00:03:50,940 --> 00:03:56,100
+time and they help me to know whether it is it
+
+47
+00:03:56,100 --> 00:03:59,880
+talks about the present or the future read the
+
+48
+00:03:59,880 --> 00:04:02,240
+other one please اسمه the other sentence
+
+49
+00:04:07,250 --> 00:04:12,090
+Thank you he is leaving at noon tomorrow tomorrow
+
+50
+00:04:12,090 --> 00:04:15,070
+this is the future again it is used to express
+
+51
+00:04:15,070 --> 00:04:21,050
+what okay present progressive expressed by the
+
+52
+00:04:21,050 --> 00:04:23,770
+future thank you read the other example please
+
+53
+00:04:23,770 --> 00:04:27,110
+okay
+
+54
+00:04:27,110 --> 00:04:31,090
+after lunch after lunch I am meeting a friend of
+
+55
+00:04:31,090 --> 00:04:35,930
+mine and we are going shopping would you likeThank
+
+56
+00:04:35,930 --> 00:04:38,930
+you. We are going shopping. I'm visiting my
+
+57
+00:04:38,930 --> 00:04:44,150
+sister. Okay. So again, give me other situations.
+
+58
+00:04:44,310 --> 00:04:47,130
+Use the present progressive to express the future.
+
+59
+00:04:47,630 --> 00:04:54,790
+Go on. Talk about yourself. Yeah. Thank you. Good.
+
+60
+00:05:00,120 --> 00:05:02,320
+Okay this is right but we want the present
+
+61
+00:05:02,320 --> 00:05:05,340
+progressive this is good it expresses the future
+
+62
+00:05:05,340 --> 00:05:09,920
+I'm writing my assignment at twelve thank you very
+
+63
+00:05:09,920 --> 00:05:15,820
+much good when are you having lunch today when
+
+64
+00:05:15,820 --> 00:05:20,980
+are you having lunch today at one I'm having lunch
+
+65
+00:05:20,980 --> 00:05:25,380
+at one okay I'm going shopping at three I'm
+
+66
+00:05:25,380 --> 00:05:28,440
+visiting my sister at four and so on
+
+67
+00:05:32,050 --> 00:05:37,110
+الان كما قلنا ال present progressive يمكن ان يكون
+
+68
+00:05:37,110 --> 00:05:41,830
+استخدامه لتظهر المستقبل إذا كنا نتحدث عن حدث مخطط
+
+69
+00:05:41,830 --> 00:05:49,410
+أو اهتمام محدد اهتمام محدد اهتمام مخصص اهتمام
+
+70
+00:05:49,410 --> 00:05:50,690
+اهتمام اهتمام اهتمام اهتمام اهتمام اهتمام اهتمام
+
+71
+00:05:50,690 --> 00:05:51,710
+اهتمام اهتمام اهتمام اهتمام اهتمام اهتمام اهتمام
+
+72
+00:05:51,710 --> 00:05:51,710
+اهتمام اهتمام اهتمام اهتمام اهتمام اهتمام اهتمام
+
+73
+00:05:51,710 --> 00:05:51,830
+اهتمام اهتمام اهتمام اهتمام اهتمام اهتمام اهتمام
+
+74
+00:05:51,830 --> 00:05:52,370
+اهتمام اهتمام اهتمام اهتمام اهتمام اهتمام اهتمام
+
+75
+00:05:52,370 --> 00:05:56,890
+اهتمام اهتمام اهتمام
+
+76
+00:06:04,730 --> 00:06:14,610
+الأن مرة أخرى إذا كنت تنظر إلى هذا الفعل رمضان
+
+77
+00:06:14,610 --> 00:06:20,570
+رمضان
+
+78
+00:06:20,570 --> 00:06:24,510
+هل نستطيع أن نستخدم رمضان في المتقدم لتظهر
+
+79
+00:06:24,510 --> 00:06:30,830
+المستقبل؟الان استمع، اقول ان انا انام، يمكنك تجهيز
+
+80
+00:06:30,830 --> 00:06:35,390
+الطعام، أليس كذلك؟ انا أزور، يمكنك تجهيز التجهيز،
+
+81
+00:06:35,390 --> 00:06:41,330
+يمكنك تخطيط الأحداث، انا أدرس، انا أبقى في المنزل
+
+82
+00:06:41,330 --> 00:06:46,780
+الليلة، لكن ماذا عن الشمس؟هل لدينا أي شيء يتعلق
+
+83
+00:06:46,780 --> 00:06:51,500
+بالتوضيح للغياب أو التخطيط للغياب؟ لا لذلك هل
+
+84
+00:06:51,500 --> 00:06:56,620
+نستخدمه في الـ progressive لتظهر المستقبل؟ لا مع
+
+85
+00:06:56,620 --> 00:06:59,180
+بعض الفعاليه مع الغياب لا نستطيع استخدام هذه
+
+86
+00:06:59,180 --> 00:07:02,900
+الفعالية لا نستطيع استخدامها لتظهرها ، لذلك إذا
+
+87
+00:07:02,900 --> 00:07:06,840
+قال شخص ما أنه يتغيب يجب أن يكون عند ما؟ الآن في
+
+88
+00:07:06,840 --> 00:07:10,580
+هذا الوقت في هذا الوقت يجب أن يتغيب في الوقت
+
+89
+00:07:10,580 --> 00:07:10,960
+الحاضر
+
+90
+00:07:16,790 --> 00:07:28,590
+yeah look at this sentence read it please okay
+
+91
+00:07:28,590 --> 00:07:33,490
+thank you it is not a planned event okay we cannot
+
+92
+00:07:33,490 --> 00:07:36,690
+plan it we cannot plan it yes go on complete
+
+93
+00:07:45,410 --> 00:07:56,210
+Okay thank you now when I say I'm visiting my
+
+94
+00:07:56,210 --> 00:08:01,750
+sister tomorrow
+
+95
+00:08:01,750 --> 00:08:11,190
+now I'm visiting how did we know that this tense
+
+96
+00:08:11,190 --> 00:08:16,990
+the progressive expresses the future yeahtomorrow
+
+97
+00:08:16,990 --> 00:08:22,610
+هذا الكلمة تشير إلى ما تشير إلى المستقبل حسنا؟
+
+98
+00:08:22,610 --> 00:08:27,450
+لذلك الآن عندما أخبرك ان انتظر انهم يلعبوا كتابة
+
+99
+00:08:27,450 --> 00:08:30,070
+كتابة ان انتظر ان انتظر ان انتظر ان انتظر ان انتظر
+
+100
+00:08:30,070 --> 00:08:33,190
+ان انتظر ان انتظر ان انتظر ان انتظر ان انتظر ان
+
+101
+00:08:33,190 --> 00:08:34,490
+انتظر ان انتظر ان انتظر ان انتظر ان انتظر ان انتظر
+
+102
+00:08:34,490 --> 00:08:36,250
+ان انتظر ان انتظر ان انتظر ان انتظر ان انتظر ان
+
+103
+00:08:36,250 --> 00:08:36,630
+انتظر ان انتظر ان انتظر ان انتظر ان انتظر ان انتظر
+
+104
+00:08:36,630 --> 00:08:36,630
+ان انتظر ان انتظر ان انتظر ان انتظر ان انتظر ان
+
+105
+00:08:36,630 --> 00:08:44,150
+انتظر ان
+
+106
+00:08:44,150 --> 00:08:56,820
+انتظفي المستقبل حسناً
+
+107
+00:08:56,820 --> 00:09:03,100
+إذا ذهبت إلى الكتابة أحيانًا تخيل أنك وصلت خلال
+
+108
+00:09:03,100 --> 00:09:07,140
+اللحظة إلى الكتابة في السبت و تقول لهم أريد أن
+
+109
+00:09:07,140 --> 00:09:15,340
+أبقى حتى العشرة يقولون أننا نغلق في السبتwe close
+
+110
+00:09:15,340 --> 00:09:22,960
+at eight okay she comes from rafah the bus from
+
+111
+00:09:22,960 --> 00:09:32,900
+rafah to gaza okay leaves at seven okay you want
+
+112
+00:09:32,900 --> 00:09:37,160
+toreceive your brother in the airport you are
+
+113
+00:09:37,160 --> 00:09:41,940
+waiting you knew that the plane from dubai for
+
+114
+00:09:41,940 --> 00:09:48,220
+example arrives at ten tonight arrives at ten okay
+
+115
+00:09:48,220 --> 00:09:51,980
+now arrives leaves
+
+116
+00:09:54,050 --> 00:10:00,110
+هذا ماذا؟ سمبل ولكنه مستخدم لتعبير عن ماذا؟
+
+117
+00:10:00,110 --> 00:10:04,950
+المستقبل، مستخدم لتعبير عن المستقبل أحيانًا إذا
+
+118
+00:10:04,950 --> 00:10:10,450
+أردنا نتحدث عن طائرات، عن طرق، عن أشياء مثل ذلك،
+
+119
+00:10:10,450 --> 00:10:16,050
+عن مؤسسات، حسنًا، مؤسسة، كتابة مفتوح في وقت معين
+
+120
+00:10:16,050 --> 00:10:20,750
+ومغلق في وقت معين، صحيح؟ لذلك عندما نتحدث عنها،
+
+121
+00:10:20,750 --> 00:10:26,570
+الأشياء التي تتطور مثل ذلكin the future we use the
+
+122
+00:10:26,570 --> 00:10:30,650
+present simple to express the future read please
+
+123
+00:10:30,650 --> 00:10:42,810
+this example yes read okay
+
+124
+00:10:42,810 --> 00:10:45,030
+opens
+
+125
+00:10:46,020 --> 00:10:49,380
+at ten o'clock tomorrow morning lock opens this is
+
+126
+00:10:49,380 --> 00:10:53,780
+present simple and we are talking about the future
+
+127
+00:10:53,780 --> 00:10:59,040
+go on please classesالدراسات تبدأ في الأسبوع
+
+128
+00:10:59,040 --> 00:11:04,380
+القادم، وانت الآن في ميلاد الشمس، وانت تقول
+
+129
+00:11:04,380 --> 00:11:10,240
+ما؟ دراسات تبدأ، وانت تقول ما؟ دراسات تبدأ، وانت
+
+130
+00:11:10,240 --> 00:11:10,240
+تقول ما؟ دراسات تبدأ، وانت تقول ما؟ دراسات تبدأ،
+
+131
+00:11:10,240 --> 00:11:10,240
+وانت تقول ما؟ دراسات تبدأ، وانت تقول ما؟ دراسات
+
+132
+00:11:10,240 --> 00:11:10,240
+تبدأ، وانت تقول ما؟ دراسات تبدأ، وانت تقول ما؟
+
+133
+00:11:10,240 --> 00:11:10,240
+دراسات تبدأ، وانت تقول ما؟ دراسات تبدأ، وانت تقول
+
+134
+00:11:10,240 --> 00:11:13,560
+ما؟ دراسات تبدأ، وانت تقول ما؟ دراسات تبدأ، وانت
+
+135
+00:11:13,560 --> 00:11:18,420
+تقول ما؟ دراسات تبدأ، وانت تقول ما؟ دراسات تبدأ
+
+136
+00:11:23,590 --> 00:11:31,470
+الطيب يصل والطيب يترك الطيب يترك
+
+137
+00:11:31,470 --> 00:11:33,730
+الطيب يترك الطيب يترك طيب طيب طيب طيب طيب طيب طيب
+
+138
+00:11:33,730 --> 00:11:33,730
+طيب طيب طيب طيب طيب طيب طيب طيب طيب طيب طيب طيب
+
+139
+00:11:33,730 --> 00:11:34,710
+طيب طيب طيب طيب طيب طيب طيب طيب طيب طيب طيب طيب
+
+140
+00:11:34,710 --> 00:11:34,930
+طيب طيب طيب طيب طيب طيب طيب طيب طيب طيب طيب طيب
+
+141
+00:11:34,930 --> 00:11:34,950
+طيب طيب طيب طيب طيب طيب طيب طيب طيب طيب طيب طيب
+
+142
+00:11:34,950 --> 00:11:38,490
+طيب طيب طيب طيب طيب
+
+143
+00:11:38,490 --> 00:11:46,150
+طيب طيب طيب طيب
+
+144
+00:11:46,150 --> 00:11:51,960
+طNow, yes مروة. The simple present can also be
+
+145
+00:11:51,960 --> 00:11:54,220
+used to express future time in a sentence
+
+146
+00:11:54,220 --> 00:11:57,280
+concerning even our own definite schedule or
+
+147
+00:11:57,280 --> 00:12:01,660
+timetable. This is definite, fixed, okay. Yeah, go
+
+148
+00:12:01,660 --> 00:12:05,060
+on. These sentences usually contain future-time
+
+149
+00:12:05,060 --> 00:12:09,090
+words. Future-time wordswhen I say it opens
+
+150
+00:12:09,090 --> 00:12:13,750
+tomorrow morning okay it arrives at it arrives
+
+151
+00:12:13,750 --> 00:12:18,350
+tonight okay you should use words like that okay
+
+152
+00:12:18,350 --> 00:12:22,510
+to help the reader understand that you are talking
+
+153
+00:12:22,510 --> 00:12:26,570
+about the future okay go on only few words are
+
+154
+00:12:26,570 --> 00:12:30,530
+used in this way for example open, close, begin,
+
+155
+00:12:30,970 --> 00:12:33,850
+end, start, finish, arrive, leave, come, return
+
+156
+00:12:34,090 --> 00:12:38,270
+شكرا لك لذلك لا يمكننا أن نستخدم كل الكلمات في إسم
+
+157
+00:12:38,270 --> 00:12:49,570
+الحجر لتوصيل المستقبل الآن دعاء
+
+158
+00:12:49,570 --> 00:13:00,130
+متى ستغادر المدرسة اليوم؟ مجددا أخبرني متى متى
+
+159
+00:13:00,130 --> 00:13:11,270
+ستغادر؟ متى؟ نعمtwo okay now yeah now we say she
+
+160
+00:13:11,270 --> 00:13:16,290
+is leaving at what at one okay she's leaving at
+
+161
+00:13:16,290 --> 00:13:22,470
+one at two she
+
+162
+00:13:22,470 --> 00:13:31,390
+will be having lunch okay
+
+163
+00:13:32,630 --> 00:13:36,210
+at two she will be having lunch what will you be
+
+164
+00:13:36,210 --> 00:13:40,190
+doing at two thirty at two thirty what will you be
+
+165
+00:13:40,190 --> 00:13:45,010
+doing yes she
+
+166
+00:13:45,010 --> 00:13:51,970
+will be okay
+
+167
+00:13:51,970 --> 00:14:02,440
+sleeping she will be sleeping okay at fourshe will
+
+168
+00:14:02,440 --> 00:14:11,400
+be studying what
+
+169
+00:14:11,400 --> 00:14:15,720
+will you be doing at 10 tonight? I will be
+
+170
+00:14:15,720 --> 00:14:21,800
+watching TV what will you be doing tomorrow at
+
+171
+00:14:21,800 --> 00:14:22,340
+this time?
+
+172
+00:14:27,040 --> 00:14:30,560
+I will be studying good what will you be doing
+
+173
+00:14:30,560 --> 00:14:37,920
+tomorrow evening yes I will be sleeping good thank
+
+174
+00:14:37,920 --> 00:14:46,360
+you what will you be doing at ten today
+
+175
+00:14:46,360 --> 00:14:47,560
+at ten in the morning
+
+176
+00:14:52,640 --> 00:14:56,480
+I will be studying good thank you and what about
+
+177
+00:14:56,480 --> 00:15:02,340
+you what will you be doing at 10 I will be having
+
+178
+00:15:02,340 --> 00:15:09,040
+breakfast okay I will be having breakfast now a
+
+179
+00:15:09,040 --> 00:15:14,360
+friend of mine wanted to visit me at 10 tonight I
+
+180
+00:15:14,360 --> 00:15:19,420
+told him sorry don't come at 10because I will be
+
+181
+00:15:19,420 --> 00:15:24,840
+sleeping at ten okay I will be sleeping look two
+
+182
+00:15:24,840 --> 00:15:29,580
+thirty she will be sleeping she will be sleeping
+
+183
+00:15:29,580 --> 00:15:34,500
+now this is what this
+
+184
+00:15:34,500 --> 00:15:41,580
+is ten in the evening okay will be sleeping when
+
+185
+00:15:41,580 --> 00:15:45,650
+did the or when will the action startbefore ten
+
+186
+00:15:45,650 --> 00:15:49,470
+very good the action will start before ten will
+
+187
+00:15:49,470 --> 00:15:55,510
+the action continue after ten yes okay so will be
+
+188
+00:15:55,510 --> 00:16:00,730
+sleeping this action or this time will be in the
+
+189
+00:16:00,730 --> 00:16:05,060
+middle of the action okayit will be in the middle
+
+190
+00:16:05,060 --> 00:16:08,640
+of the action it means that the action starts
+
+191
+00:16:08,640 --> 00:16:14,180
+before and continues after okay what do we call
+
+192
+00:16:14,180 --> 00:16:17,560
+this tense will be studying will be sleeping yeah
+
+193
+00:16:17,560 --> 00:16:23,200
+future progressive thank you future progressive i
+
+194
+00:16:23,200 --> 00:16:30,340
+will be driving home at one what about you ياسمين
+
+195
+00:16:30,340 --> 00:16:36,250
+what will you be doing at oneI will be walking to
+
+196
+00:16:36,250 --> 00:16:42,330
+my home. Yes, tell me more about yourself. What
+
+197
+00:16:42,330 --> 00:16:46,190
+will you be doing in the future? Yes, what will
+
+198
+00:16:46,190 --> 00:16:52,310
+you be doing on Friday morning? I will be visiting
+
+199
+00:16:52,310 --> 00:16:55,770
+my uncle. Thank you. What will you be doing Friday
+
+200
+00:16:55,770 --> 00:16:56,350
+morning?
+
+201
+00:16:59,280 --> 00:17:02,040
+I will be sitting with my sister. Good thank you.
+
+202
+00:17:02,260 --> 00:17:04,700
+And what about you? What will you be doing Friday
+
+203
+00:17:04,700 --> 00:17:10,240
+morning? I will be studying English. Thank you. I
+
+204
+00:17:10,240 --> 00:17:15,660
+will be cleaning my house. Thank you very much. I
+
+205
+00:17:15,660 --> 00:17:19,060
+will be cleaning my house. Okay, would you please
+
+206
+00:17:19,060 --> 00:17:24,420
+read the example?I will begin to study at event
+
+207
+00:17:24,420 --> 00:17:29,320
+you will come at eight I will be studying when you
+
+208
+00:17:29,320 --> 00:17:35,440
+come okay thank you look I begin study I will
+
+209
+00:17:35,440 --> 00:17:41,000
+begin at seven you will come at eight I will be
+
+210
+00:17:41,000 --> 00:17:44,520
+studying when you come when will you start
+
+211
+00:17:44,520 --> 00:17:51,310
+studyingقبل ذلك و هل ستستمر بعد ذلك الوقت؟ نعم
+
+212
+00:17:51,310 --> 00:18:00,990
+بالطبع، نعم، أكمل، أرجوك شكرا،
+
+213
+00:18:00,990 --> 00:18:03,790
+سيكون في تقدم، عندما أقول at ten, I will be
+
+214
+00:18:03,790 --> 00:18:11,430
+sleeping الاختصار سيستمر، الاختصار سيكون في تقدم،
+
+215
+00:18:11,430 --> 00:18:12,710
+اتفقنا، اقرأ مثل الأخر
+
+216
+00:18:23,070 --> 00:18:27,570
+thank you we can express the future by using what
+
+217
+00:18:27,570 --> 00:18:31,750
+going to I'm going to write well okay and you know
+
+218
+00:18:31,750 --> 00:18:38,390
+the difference between well and going to now
+
+219
+00:18:38,390 --> 00:18:42,770
+look
+
+220
+00:18:42,770 --> 00:18:47,140
+at this sentencewhen I say don't worry she will be
+
+221
+00:18:47,140 --> 00:18:53,460
+coming soon she will come soon she will be coming
+
+222
+00:18:53,460 --> 00:19:00,520
+soon we are talking about the future is there any
+
+223
+00:19:00,520 --> 00:19:04,180
+definite time mentioned in the future look at the
+
+224
+00:19:04,180 --> 00:19:11,220
+sentence soon okay soon it can be a minute and can
+
+225
+00:19:11,220 --> 00:19:16,210
+beأشهر يمكن أن تكون في يوم واحد وما إلى ذلك، ليس
+
+226
+00:19:16,210 --> 00:19:19,110
+مختلفاً، إنه مختلف من القول في الساعة السادسة، على
+
+227
+00:19:19,110 --> 00:19:22,390
+سبيل المثال، في الساعة السادسة، هذا وقت محدد ووقت
+
+228
+00:19:22,390 --> 00:19:28,080
+محدد. حسنًا، عندما تتكلم عنthe future about
+
+229
+00:19:28,080 --> 00:19:31,520
+indefinite time in the future you can use the
+
+230
+00:19:31,520 --> 00:19:35,800
+symbol future or the future progressive okay they
+
+231
+00:19:35,800 --> 00:19:41,320
+are the same but if you if you are talking about a
+
+232
+00:19:41,320 --> 00:19:46,100
+definite time in the future okay you can use what
+
+233
+00:19:46,100 --> 00:19:50,480
+the symbol future okay read please will you read
+
+234
+00:19:50,480 --> 00:19:54,880
+the first example go
+
+235
+00:19:54,880 --> 00:20:04,930
+onthank you very much complete please thank
+
+236
+00:20:04,930 --> 00:20:13,050
+you
+
+237
+00:20:13,050 --> 00:20:15,890
+very much okay so
+
+238
+00:20:17,510 --> 00:20:21,970
+في هذه الحالة لا وقت محدد يمكننا أن نستخدم المصطلح
+
+239
+00:20:21,970 --> 00:20:34,010
+future أو المصطلح progressive الآن دعونا
+
+240
+00:20:34,010 --> 00:20:37,190
+نتكلم عن الدعاء مرة أخرى
+
+241
+00:21:01,990 --> 00:21:08,790
+عشان دعاء يذهب للعشاء في السادسةwhen she goes to
+
+242
+00:21:08,790 --> 00:21:17,750
+bed she should have completed all her duties she
+
+243
+00:21:17,750 --> 00:21:25,470
+will
+
+244
+00:21:25,470 --> 00:21:36,870
+have written her homeworkShe will have written her
+
+245
+00:21:36,870 --> 00:21:41,390
+homework. She will have cleaned the house. She
+
+246
+00:21:41,390 --> 00:21:48,090
+will have watched TV. Tell me about yourself. When
+
+247
+00:21:48,090 --> 00:21:52,590
+you go to bed, what will you have done? What will
+
+248
+00:21:52,590 --> 00:21:54,170
+you have done when you go to bed?
+
+249
+00:21:58,120 --> 00:22:03,240
+سأقرأ بعض الأقصاد من القرآن الكريم. شكرا جزيلا.
+
+250
+00:22:03,560 --> 00:22:05,320
+نعم، ماذا ستفعل؟
+
+251
+00:22:11,470 --> 00:22:14,270
+I will have done my homework very good thank you
+
+252
+00:22:14,270 --> 00:22:17,230
+yes I will have brushed my teeth I will have
+
+253
+00:22:17,230 --> 00:22:20,410
+brushed my teeth very good now next week we are
+
+254
+00:22:20,410 --> 00:22:25,230
+having there is عيد right okay and you know people
+
+255
+00:22:25,230 --> 00:22:30,430
+especially ladies are so busy at homes okay now
+
+256
+00:22:30,430 --> 00:22:35,850
+the first day imagine it is Tuesday what will you
+
+257
+00:22:35,850 --> 00:22:42,110
+have doneعشان تيوزيديا صباحا الاشياء اللي يجب ان
+
+258
+00:22:42,110 --> 00:22:47,870
+تتمويلها قبلها نحن سنفعلها نفعلها نفعلها نفعلها
+
+259
+00:22:47,870 --> 00:22:49,130
+نفعلها نفعلها نفعلها نفعلها نفعلها نفعلها نفعلها
+
+260
+00:22:49,130 --> 00:22:49,910
+نفعلها نفعلها نفعلها نفعلها نفعلها نفعلها نفعلها
+
+261
+00:22:49,910 --> 00:22:50,070
+نفعلها نفعلها نفعلها نفعلها نفعلها نفعلها نفعلها
+
+262
+00:22:50,070 --> 00:22:55,590
+نفعلها نفعلها نفعلها
+
+263
+00:22:55,590 --> 00:23:00,330
+نفعلها نفعلها نفعلها نفعلها نفعلها نفعلها نفعلها
+
+264
+00:23:00,330 --> 00:23:00,510
+نفعلها نفعلها نفعلها نفعلها نفعلها نفعلها نفعلها
+
+265
+00:23:00,510 --> 00:23:03,250
+نفعلها نفعلها نفعلها نفعلها نفعلها
+
+266
+00:23:04,660 --> 00:23:07,860
+Okay, bought a new dress. Again, what will you
+
+267
+00:23:07,860 --> 00:23:12,440
+have done؟ Say it again. Good. I will have bought
+
+268
+00:23:12,440 --> 00:23:14,660
+a new dress. Thank you. And what about you, Noor?
+
+269
+00:23:16,760 --> 00:23:19,600
+Okay, will have bought some chocolates and sweets.
+
+270
+00:23:19,740 --> 00:23:23,380
+Good. Thank you. And what about you? Good. Thank
+
+271
+00:23:23,380 --> 00:23:29,360
+you very much. Yeah, go on. Yes, please. I will
+
+272
+00:23:29,360 --> 00:23:32,320
+have called my friends. Good. Yes, please. Go on.
+
+273
+00:23:32,360 --> 00:23:35,100
+What will you have done?yes you
+
+274
+00:23:41,820 --> 00:23:46,000
+Okay I will have eaten some chocolates okay thank
+
+275
+00:23:46,000 --> 00:23:49,100
+you very much okay now when I say I will have
+
+276
+00:23:49,100 --> 00:23:52,440
+eaten I will have cleaned I will have bought I
+
+277
+00:23:52,440 --> 00:23:56,620
+will have visited okay now we are talking about a
+
+278
+00:23:56,620 --> 00:24:01,540
+certain time in the future she will have written
+
+279
+00:24:01,540 --> 00:24:05,800
+her homework can you tell me when do we usually or
+
+280
+00:24:05,800 --> 00:24:10,650
+before when what do we call this tensehave will
+
+281
+00:24:10,650 --> 00:24:15,730
+have written what do we call it future perfect
+
+282
+00:24:15,730 --> 00:24:21,350
+thank you when do we use it okay in the future you
+
+283
+00:24:21,350 --> 00:24:24,770
+are right this is a clever answer but when exactly
+
+284
+00:24:24,770 --> 00:24:27,430
+in the future yeah thank you
+
+285
+00:24:33,290 --> 00:24:38,170
+عظيم، الآن عندما أقول في السادسة، هي ستكون مكتوبة،
+
+286
+00:24:38,170 --> 00:24:44,410
+هي ستكون مكتوبة، هذا يعني أن هذه المشروع، الكتابة
+
+287
+00:24:44,410 --> 00:24:49,310
+على سبيل المثال، سيتم إكماله قبل هذه الوقت، وهو
+
+288
+00:24:49,310 --> 00:24:55,290
+وقت مستقل، المشروع سيتم إكماله قبل هذه الوقت في
+
+289
+00:24:55,290 --> 00:24:55,890
+المستقبل
+
+290
+00:25:04,850 --> 00:25:09,690
+ماذا تقرأ؟ انا سأدرس في شهر يوليو و سأراك في شهر
+
+291
+00:25:09,690 --> 00:25:12,170
+يوليو و في ذلك الوقت انا سأدرس في شهر يوليو و انا
+
+292
+00:25:12,170 --> 00:25:15,070
+سأدرس في شهر يوليو و انا سأدرس في شهر يوليو و انا
+
+293
+00:25:15,070 --> 00:25:16,670
+سأدرس في شهر يوليو و انا سأدرس في شهر يوليو و انا
+
+294
+00:25:16,670 --> 00:25:19,650
+سأدرس في شهر يوليو و انا سأدرس في شهر يوليو و انا
+
+295
+00:25:19,650 --> 00:25:20,970
+سأدرس في شهر يوليو و انا سأدرس في شهر يوليو و انا
+
+296
+00:25:20,970 --> 00:25:24,830
+سأدرس في شهر يوليو و انا سأدرس في شهر يوليو و انا
+
+297
+00:25:24,830 --> 00:25:27,170
+سأد
+
+298
+00:25:29,010 --> 00:25:34,350
+شكرًا لك قبل مرة أخرى أو عملية في المستقبل، هل
+
+299
+00:25:34,350 --> 00:25:39,990
+يمكنك أن تكتب قصة واحدة عن نفسك باستخدام future
+
+300
+00:25:39,990 --> 00:25:43,530
+perfect؟ حسنًا، سأعطيك ثلاثة ثانوية ثانوية فقط،
+
+301
+00:25:43,530 --> 00:25:48,850
+قصة بسيطة جدًا، كتبها، فتفكر في قصة، سأخذها منك،
+
+302
+00:25:48,850 --> 00:25:53,190
+وسأطلب من خمس طلاب، اذهب، كتب قصة واحدة عن نفسك
+
+303
+00:26:38,940 --> 00:26:43,000
+Okay, who can give me .. yeah Marwa By the time I
+
+304
+00:26:43,000 --> 00:26:45,240
+come home today, I will have finished my lecture
+
+305
+00:26:45,240 --> 00:26:48,540
+Very good, I will have By the time she returns
+
+306
+00:26:48,540 --> 00:26:52,020
+home, she will have finished her lectures No more
+
+307
+00:26:52,020 --> 00:26:55,570
+lectures, this is a good sentence, yeahwhen I
+
+308
+00:26:55,570 --> 00:26:58,930
+graduate from the university I will be where؟
+
+309
+00:26:58,930 --> 00:27:06,910
+thank you when okay so you say when I in 2017 for
+
+310
+00:27:06,910 --> 00:27:11,290
+example I will have graduated I will have
+
+311
+00:27:11,290 --> 00:27:13,930
+graduated or when I get a job I will have
+
+312
+00:27:13,930 --> 00:27:16,330
+graduated thank you good yes please
+
+313
+00:27:19,840 --> 00:27:24,380
+ممتاز جيد جدا قبل أن أذهب للجلوس سوف أفعل كل عملي
+
+314
+00:27:24,380 --> 00:27:30,960
+شكرا لك نعم أرجوك حسنا
+
+315
+00:27:30,960 --> 00:27:38,120
+عندما أرحل سوف أترك .. سوف أساعد أمي شكرا جدا جيد
+
+316
+00:27:38,120 --> 00:27:46,300
+نعم
+
+317
+00:27:47,830 --> 00:27:53,750
+We have a future test, simple and progressive and
+
+318
+00:27:53,750 --> 00:27:59,490
+perfect. So why use the present progressive to
+
+319
+00:27:59,490 --> 00:28:02,880
+express about the future?Why? To use the present
+
+320
+00:28:02,880 --> 00:28:05,440
+progressive to express the future. You know, we
+
+321
+00:28:05,440 --> 00:28:10,920
+have different tenses. Each tense has a certain
+
+322
+00:28:10,920 --> 00:28:14,860
+function, let's say, has a certain meaning. Now I
+
+323
+00:28:14,860 --> 00:28:17,640
+want to talk about a definite time in the future
+
+324
+00:28:19,250 --> 00:28:22,210
+وقت محدد على سبيل المثال او اريت ان اتكلم عن
+
+325
+00:28:22,210 --> 00:28:26,790
+التوقع في المستقبل انا استخدم ماذا انا استخدم انا
+
+326
+00:28:26,790 --> 00:28:28,590
+استخدم انا استخدم انا استخدم انا استخدم انا استخدم
+
+327
+00:28:28,590 --> 00:28:29,810
+انا استخدم انا استخدم انا استخدم انا استخدم انا
+
+328
+00:28:29,810 --> 00:28:29,810
+استخدم انا استخدم انا استخدم انا استخدم انا استخدم
+
+329
+00:28:29,810 --> 00:28:29,930
+انا استخدم انا استخدم انا استخدم انا استخدم انا
+
+330
+00:28:29,930 --> 00:28:30,330
+استخدم انا استخدم انا استخدم انا استخدم انا استخدم
+
+331
+00:28:30,330 --> 00:28:31,290
+انا استخدم انا استخدم انا استخدم انا استخدم انا
+
+332
+00:28:31,290 --> 00:28:32,910
+استخدم انا استخدم انا استخدم انا استخدم انا استخدم
+
+333
+00:28:32,910 --> 00:28:36,150
+انا استخدم انا استخدم انا
+
+334
+00:28:36,150 --> 00:28:45,010
+استخدم انا
+
+335
+00:28:45,010 --> 00:28:45,410
+استخ
+
+336
+00:28:48,590 --> 00:28:53,270
+وإذا أردت أن أتحدث عن استخدام المستقبل المتقدم،
+
+337
+00:28:53,270 --> 00:28:58,490
+فهو يحتوي على معنى أخر، فالعمل أو هذا النقطة التي
+
+338
+00:28:58,490 --> 00:29:03,350
+أتحدث عنها في المستقبل سيكون في أعضاء العمل، ماذا
+
+339
+00:29:03,350 --> 00:29:08,110
+عن المستقبل المتقدم؟ مستقبل المستقبل المتقدم لديه
+
+340
+00:29:08,110 --> 00:29:12,710
+استخدام مختلف، حسنًا، هناك بعض التجارب، حسنًا كما
+
+341
+00:29:12,710 --> 00:29:20,020
+قلت لك الآن عندما تغادر المدرسةلا تترك المدرسة حتى
+
+342
+00:29:20,020 --> 00:29:24,620
+لو انك انتهيت من دراساتك، حسنًا لديك بعض الدراسات،
+
+343
+00:29:24,620 --> 00:29:29,340
+الأشياء مرتبطة مع بعضك، لذلك تستخدم الـ perfect،
+
+344
+00:29:29,340 --> 00:29:35,540
+تستخدم ال progressive لتوصيل هذا الشيءespecially
+
+345
+00:29:35,540 --> 00:29:39,480
+you know when we are talking about a future event
+
+346
+00:29:39,480 --> 00:29:42,320
+and there are arrangements we use this tense so
+
+347
+00:29:42,320 --> 00:29:46,420
+again each tense expresses a certain meaning
+
+348
+00:29:46,420 --> 00:29:50,240
+conveys a certain message to the reader or to the
+
+349
+00:29:50,240 --> 00:29:54,380
+listener okay sometimes they meet in certain
+
+350
+00:29:54,380 --> 00:29:59,900
+points sometimes but usually it's clear that each
+
+351
+00:29:59,900 --> 00:30:10,370
+one has its own meaning okayالأن نور
+
+352
+00:30:10,370 --> 00:30:21,310
+لديها أخت صغيرة نور لديها أخت صغيرة عندما تدرس في
+
+353
+00:30:21,310 --> 00:30:26,110
+المنزل أختها تصرخ
+
+354
+00:30:26,110 --> 00:30:29,530
+فأمها
+
+355
+00:30:29,530 --> 00:30:33,270
+ستساعدها
+
+356
+00:30:33,270 --> 00:30:39,510
+كيف؟by putting her sister to sleep the little
+
+357
+00:30:39,510 --> 00:30:46,330
+sister the sister now the little sister okay went
+
+358
+00:30:46,330 --> 00:30:54,150
+will go to bed at seven okay the little baby will
+
+359
+00:30:54,150 --> 00:31:03,130
+go to bed at seven and at from seven to nineمن
+
+360
+00:31:03,130 --> 00:31:05,990
+الساعة السادسة إلى السادسة إذا قلنا هذا فالطفل
+
+361
+00:31:05,990 --> 00:31:10,110
+سيذهب إلى الساعة السادسة ويبدأ حتى الساعة السادسة
+
+362
+00:31:10,110 --> 00:31:17,230
+طفل سيبقى
+
+363
+00:31:17,230 --> 00:31:21,390
+نائم
+
+364
+00:31:21,390 --> 00:31:26,710
+ل2
+
+365
+00:31:26,710 --> 00:31:33,430
+ساعات الأن اسمععندما أتكلم عن هذه اللحظة في
+
+366
+00:31:33,430 --> 00:31:39,250
+المستقبل، سنذهب للجلوس في الساعة السادسة، في
+
+367
+00:31:39,250 --> 00:31:45,710
+الساعة التاسعة، فالطفل سيبقى ينام. إذا كنت تتكلم
+
+368
+00:31:45,710 --> 00:31:50,950
+عن لحظة أخرى، عندما نذهب للجلوس في الساعة التاسعة،
+
+369
+00:31:50,950 --> 00:32:00,620
+فالطفل سيبقى ينام ل2 ساعات.الطفل سيكون منام ل2
+
+370
+00:32:00,620 --> 00:32:08,340
+ساعتين عندما اتقبلت المدرسة؟ اتقبلت المدرسة في
+
+371
+00:32:08,340 --> 00:32:15,620
+سبتمبر، صحيح؟ اتقبلت المدرسة في سبتمبر في أول
+
+372
+00:32:15,620 --> 00:32:20,380
+نوفمبر ستكون
+
+373
+00:32:24,200 --> 00:32:28,120
+Okay studying or coming to the university for two
+
+374
+00:32:28,120 --> 00:32:33,520
+months okay will
+
+375
+00:32:33,520 --> 00:32:39,480
+have will have been studying will have been coming
+
+376
+00:32:39,480 --> 00:32:44,740
+to the university okay yeah I have an example yes
+
+377
+00:32:44,740 --> 00:32:50,640
+go on before I run away from the university I
+
+378
+00:32:50,640 --> 00:32:55,480
+would have been studying for four yearsشكرا جزيلا
+
+379
+00:32:55,480 --> 00:33:02,900
+جدا جيد سوف أتدرس سوف أتدرس عندما جاءت لعبة نجوة
+
+380
+00:33:02,900 --> 00:33:11,100
+اليوم عندما جاءت لعبة نجوة اليوم عندما جاءت لعبة
+
+381
+00:33:11,100 --> 00:33:14,180
+نجوة اليوم عندما جاءت لعبة نجوة اليوم
+
+382
+00:33:20,230 --> 00:33:30,910
+ثلاثة ثلاثة حسنا ات ثلاثة ات ات ات ات ات ات ات ات
+
+383
+00:33:30,910 --> 00:33:32,750
+ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات
+
+384
+00:33:32,750 --> 00:33:34,570
+ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات
+
+385
+00:33:34,570 --> 00:33:37,270
+ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات
+
+386
+00:33:37,270 --> 00:33:37,310
+ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات
+
+387
+00:33:37,310 --> 00:33:39,630
+ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات ات
+
+388
+00:33:39,630 --> 00:33:48,090
+ات ات ات ات ات ات ات ات
+
+389
+00:33:48,090 --> 00:33:55,450
+اتwhen we talked about the future perfect when she
+
+390
+00:33:55,450 --> 00:34:01,230
+goes to bed she will have completed، she will have
+
+391
+00:34:01,230 --> 00:34:04,890
+done، she will have eaten، she will have written
+
+392
+00:34:06,600 --> 00:34:10,140
+Are we interested in the duration of the activity؟
+
+393
+00:34:10,140 --> 00:34:15,080
+No. Now, when I say for example, will have been
+
+394
+00:34:15,080 --> 00:34:19,440
+sitting, will have been studying, will have been
+
+395
+00:34:19,440 --> 00:34:24,960
+sleeping, what do you understand؟ماذا تفهمين؟ نعم
+
+396
+00:34:24,960 --> 00:34:29,900
+بفضل الله الامر يؤثر على المستقبل المستقبل، حسنا؟
+
+397
+00:34:29,900 --> 00:34:34,040
+المشروع سيحصل على مستقبل و هذا المستقبل، هذا
+
+398
+00:34:34,040 --> 00:34:39,240
+التقدم نحن نتحدث عن المستقبل مرة أخرى، حسنا؟ لذلك
+
+399
+00:34:39,240 --> 00:34:46,040
+المستقبل، المشروع سيحصل على مستقبل و سيستمر في
+
+400
+00:34:46,040 --> 00:34:53,140
+المستقبل قبل ما؟ انظرعندما قلنا ات فارتي لازم، ليس
+
+401
+00:34:53,140 --> 00:34:58,840
+ات فارتي، ليس ات فارتي، صح؟ لازم هذه الوقت هي وقت
+
+402
+00:34:58,840 --> 00:35:03,220
+المستقبل عندما نتحدث عن نوفمبر، نوفمبر هو أيضًا
+
+403
+00:35:03,220 --> 00:35:08,920
+وقت المستقبل، لذا فإن المشروع سيكون ماذا؟ في اتفاق
+
+404
+00:35:08,920 --> 00:35:15,860
+أو في دورة قبل هذا النقطة في الوقت، نعم، هل يمكنك
+
+405
+00:35:15,860 --> 00:35:17,740
+أن تفكر في أشخاص مثلها؟
+
+406
+00:35:28,360 --> 00:35:31,120
+الأن .. نعم .. نعم أرجوك تريدين أن تقومي بتصحيح
+
+407
+00:35:31,120 --> 00:35:33,920
+مثالي .. تريدين أن تقومي بتصحيح مثالي .. تريدين أن
+
+408
+00:35:33,920 --> 00:35:34,180
+تقومي بتصحيح مثالي .. تريدين أن تقومي بتصحيح مثالي
+
+409
+00:35:34,180 --> 00:35:34,180
+.. تريدين أن تقومي بتصحيح مثالي .. تريدين أن تقومي
+
+410
+00:35:34,180 --> 00:35:34,280
+بتصحيح مثالي .. تريدين أن تقومي بتصحيح مثلي ..
+
+411
+00:35:34,280 --> 00:35:35,040
+تريدين أن تقومي بتصحيح مثلي .. تريدين أن تقومي
+
+412
+00:35:35,040 --> 00:35:39,780
+بتصحيح مثلي .. تريدين أن تقومي بتصحيح مثلي ..
+
+413
+00:35:39,780 --> 00:35:47,140
+تريدين أن تقومي بتصحيح مثلي .. تريدين
+
+414
+00:35:47,140 --> 00:35:50,180
+أن تقومي بتصحيح
+
+415
+00:36:07,550 --> 00:36:12,050
+in ten o'clock I will have been taking two
+
+416
+00:36:12,050 --> 00:36:16,930
+lectures very good I will have been taking I will
+
+417
+00:36:16,930 --> 00:36:18,770
+have been taking thank you
+
+418
+00:36:25,190 --> 00:36:39,370
+Okay could you please read the example Okay
+
+419
+00:36:39,370 --> 00:36:45,830
+you know we are talking about a future time so the
+
+420
+00:36:45,830 --> 00:36:52,770
+action will be what in progress read بسمةThe
+
+421
+00:36:52,770 --> 00:36:56,110
+future bed represents or emphasizes the duration
+
+422
+00:36:56,110 --> 00:36:59,750
+of an activity that will be in progress before
+
+423
+00:36:59,750 --> 00:37:03,650
+another time or even in the future thank you when
+
+424
+00:37:03,650 --> 00:37:08,800
+I go to bed when I graduateI will have been
+
+425
+00:37:08,800 --> 00:37:12,840
+studying for four years when I graduate graduate
+
+426
+00:37:12,840 --> 00:37:17,060
+this is a future event right I will have been
+
+427
+00:37:17,060 --> 00:37:22,420
+studying for four years now if I want to talk
+
+428
+00:37:22,420 --> 00:37:29,300
+about myself you remember when we talked about the
+
+429
+00:37:29,300 --> 00:37:31,280
+present perfect and the present perfect
+
+430
+00:37:31,280 --> 00:37:37,780
+progressiveممكن تقول انا عشت في غزا 10 سنة او انا
+
+431
+00:37:37,780 --> 00:37:42,700
+عشت اعيش في غزا 10 سنة عشت في غزا 10 سنة عشت في
+
+432
+00:37:42,700 --> 00:37:44,720
+غزا 10 سنة عشت في غزا 10 سنة عشت في غزا 10 سنة عشت
+
+433
+00:37:44,720 --> 00:37:44,740
+في غزا 10 سنة عشت في غزا 10 سنة عشت في غزا 10 سنة
+
+434
+00:37:44,740 --> 00:37:45,200
+عشت في غزا 10 سنة عشت في غزا 10 سنة عشت في غزا 10
+
+435
+00:37:45,200 --> 00:37:46,580
+سنة عشت في غزا 10 سنة عشت في غزا 10 سنة عشت في غزا
+
+436
+00:37:46,580 --> 00:37:47,900
+10 سنة عشت في غزا 10 سنة عشت في غزا 10 سنة عشت في
+
+437
+00:37:47,900 --> 00:38:01,740
+غزا 10 سنة عشت في غزا
+
+438
+00:38:01,740 --> 00:38:10,940
+10 سنة عnext by two thousand fourteen
+
+439
+00:38:10,940 --> 00:38:21,480
+okay or two thousand let's say fifteen I will have
+
+440
+00:38:21,480 --> 00:38:30,120
+taught English for thirty years or I will have
+
+441
+00:38:33,410 --> 00:38:39,410
+been teaching which one is right I will have
+
+442
+00:38:39,410 --> 00:38:42,970
+taught or I will have been teaching which one is
+
+443
+00:38:42,970 --> 00:38:45,790
+right ياسمين I think that the sentence have the
+
+444
+00:38:45,790 --> 00:38:48,730
+same meaning I think you are right thank you good
+
+445
+00:38:48,730 --> 00:38:54,830
+okay but what you want to add something maybe will
+
+446
+00:38:54,830 --> 00:39:00,800
+have been teaching beside the durationهذه طبيعة
+
+447
+00:39:00,800 --> 00:39:08,140
+المتقدس والمتقدس والمتقدس نفسه، واحد يؤكد الحركة
+
+448
+00:39:08,140 --> 00:39:12,380
+والآخر يؤكد النتائج، انت محقة، هذا عاملاً، انت
+
+449
+00:39:12,380 --> 00:39:13,060
+محقة، شكرا
+
+450
+00:39:25,570 --> 00:39:30,290
+هل يمكنك أن تقرأ؟ قم بقراءة المثال عندما يترى
+
+451
+00:39:30,290 --> 00:39:39,010
+البروفيسور جونز انه سيقوم بالتعليم ل45 سنة عندما
+
+452
+00:39:39,010 --> 00:39:46,530
+يترى عندما يترى عندما يترى عندما يترى سيقوم
+
+453
+00:39:46,530 --> 00:39:53,640
+بالتعليم نحن نتحدث عن ماذا؟ وقت المستقبلwe are
+
+454
+00:39:53,640 --> 00:39:59,900
+talking about a future time he will have taught or
+
+455
+00:39:59,900 --> 00:40:04,540
+he will have been teaching now the question is
+
+456
+00:40:04,540 --> 00:40:08,960
+that when professor jones retires this is a
+
+457
+00:40:08,960 --> 00:40:15,340
+present simple expresses what the future can i use
+
+458
+00:40:15,340 --> 00:40:19,400
+will here will retire because this expresses the
+
+459
+00:40:19,400 --> 00:40:20,460
+future
+
+460
+00:40:22,620 --> 00:40:26,800
+yes or no can I say when he retire when he will
+
+461
+00:40:26,800 --> 00:40:31,940
+retire next month can I use the future will yeah
+
+462
+00:40:31,940 --> 00:40:35,480
+very
+
+463
+00:40:35,480 --> 00:40:37,960
+good thank you very much this is a time clause
+
+464
+00:40:37,960 --> 00:40:42,920
+okay and we use the symbol to express what to
+
+465
+00:40:42,920 --> 00:40:46,560
+express the future good would you read the last
+
+466
+00:40:46,560 --> 00:40:47,380
+point please
+
+467
+00:41:02,020 --> 00:41:08,080
+Okay thank you okay may begin in the past how may
+
+468
+00:41:08,080 --> 00:41:13,360
+begin in the past I will have been teaching when
+
+469
+00:41:13,360 --> 00:41:19,310
+did I start teaching okayالان اخبرني ماذا تحدثنا
+
+470
+00:41:19,310 --> 00:41:27,770
+عنه اليوم دعونا نجمع المواصفات الرئيسية للدراسة
+
+471
+00:41:27,770 --> 00:41:32,250
+نعم أرجوك اذهبي اذهبي تفضلي
+
+472
+00:41:41,620 --> 00:41:47,560
+thank you good I will be studying at nine I will
+
+473
+00:41:47,560 --> 00:41:50,540
+be sleeping at nine the activity will be in
+
+474
+00:41:50,540 --> 00:41:53,920
+progress at this time in the future good go on
+
+475
+00:41:53,920 --> 00:42:03,400
+another point yes you with
+
+476
+00:42:03,400 --> 00:42:05,460
+raise your voice
+
+477
+00:42:15,160 --> 00:42:23,180
+شكرا شكرا نعم أرجوك طوال
+
+478
+00:42:23,180 --> 00:42:27,980
+المشروع سأكون مبقى حياة سأكون مبقى .. هي ستكون
+
+479
+00:42:27,980 --> 00:42:35,040
+مبقى نوم شكرا أجل أحيانا يعني أن المستقبل ممتاز
+
+480
+00:42:35,040 --> 00:42:38,720
+وممتاز وممتاز
+
+481
+00:42:41,540 --> 00:42:44,520
+with some verbs this is not always okay with some
+
+482
+00:42:44,520 --> 00:42:55,120
+verbs good you are right thank you yes please good
+
+483
+00:42:55,120 --> 00:43:00,820
+so when the future when we talk about okay
+
+484
+00:43:00,820 --> 00:43:05,820
+indefinite future we can use the simple future or
+
+485
+00:43:05,820 --> 00:43:11,840
+the future progressive thank you yeahI'm afraid
+
+486
+00:43:11,840 --> 00:43:14,820
+that it would be repeated before another time
+
+487
+00:43:14,820 --> 00:43:17,740
+thank you very much good yeah simple present can
+
+488
+00:43:17,740 --> 00:43:21,440
+be used to express future time in sentences that
+
+489
+00:43:21,440 --> 00:43:26,160
+have uneven punctuation thank you good yes please
+
+490
+00:43:26,160 --> 00:43:31,120
+in the present present we use to express a future
+
+491
+00:43:31,120 --> 00:43:37,100
+a future when we talk about a planned event or a
+
+492
+00:43:37,100 --> 00:43:40,180
+different eventThank you very much
+
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/L0A1ZAn1Sro_postprocess.srt b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/L0A1ZAn1Sro_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..97da2cfd1c96260d94d3a2196c8a81ceb072e542
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/L0A1ZAn1Sro_postprocess.srt
@@ -0,0 +1,1780 @@
+1
+00:00:21,040 --> 00:00:26,920
+good morning to you all how are you again I'm fine
+
+2
+00:00:26,920 --> 00:00:30,240
+thank you but I'm not having an exam today you are
+
+3
+00:00:30,240 --> 00:00:34,000
+having exams don't worry about the exams think
+
+4
+00:00:34,000 --> 00:00:38,120
+nothing of that okay be with the grammar now can
+
+5
+00:00:38,120 --> 00:00:40,400
+you give me a sentence in English any sentence
+
+6
+00:00:40,400 --> 00:00:45,580
+think of a sentence I am
+
+7
+00:00:48,350 --> 00:00:53,310
+an Arab girl thank you very much I am the sentence
+
+8
+00:00:53,310 --> 00:01:01,510
+included I am okay Arab girl she started with I
+
+9
+00:01:01,510 --> 00:01:11,470
+what part of speech is I okay it is a pronoun it
+
+10
+00:01:11,470 --> 00:01:14,650
+is a subject good it is a subject it is a pronoun
+
+11
+00:01:15,360 --> 00:01:21,280
+الأن الـ Pronouns يستخدمون كثيرًا في إصلاح الفرصة
+
+12
+00:01:21,280 --> 00:01:26,980
+الإنقليزية هم محتاجين كثيرًا لإصلاح الفرصة ما هي
+
+13
+00:01:26,980 --> 00:01:31,880
+الـ Pronouns؟ ما هي أشكال الـ Pronouns؟ كيف نستخدم
+
+14
+00:01:31,880 --> 00:01:39,780
+الـ Pronouns؟ هذا ما سنتحدث عنه ولكن أولًا نبدأ
+
+15
+00:01:55,510 --> 00:02:00,190
+لنبدأ من هذه التعليمات، قم بقراءة السلسلة الأولى
+
+16
+00:02:00,190 --> 00:02:05,290
+أرجوك انا و انا أشترينا الطعام الاندي في المطعم،
+
+17
+00:02:05,290 --> 00:02:09,110
+لم أكن غاضبا جدا لكن انا أكلت أكتر منهم انا أكلت
+
+18
+00:02:09,110 --> 00:02:17,690
+أكتر منهم، اشترينا ماذا؟ طعام، و لم أكن غاضبا جدا
+
+19
+00:02:17,690 --> 00:02:21,910
+لكن انا أكلت أكتر منهم، ماذا تفكر في السلسلة؟ أكتر
+
+20
+00:02:21,910 --> 00:02:24,710
+من الـit، لماذا ليس الـthem؟
+
+21
+00:02:27,250 --> 00:02:32,570
+because it is a non count noun for the non count
+
+22
+00:02:32,570 --> 00:02:37,470
+nouns we use what singular verb very good we say
+
+23
+00:02:37,470 --> 00:02:42,570
+food is right news is okay thank you so this
+
+24
+00:02:42,570 --> 00:02:46,490
+should be what this should be instead of it of
+
+25
+00:02:46,490 --> 00:02:49,570
+them we say it good would you read the other
+
+26
+00:02:49,570 --> 00:02:52,950
+sentence please yeah when we were in school my
+
+27
+00:02:52,950 --> 00:02:55,370
+sister and me used to play tennis
+
+28
+00:03:01,240 --> 00:03:07,160
+my sister and I thank you my sister and I good
+
+29
+00:03:07,160 --> 00:03:10,440
+read
+
+30
+00:03:10,440 --> 00:03:13,800
+the other sentence yes please if you want to pass
+
+31
+00:03:13,800 --> 00:03:18,260
+your exams you had better study very hard for it
+
+32
+00:03:18,260 --> 00:03:27,280
+and for them okay so exams exams
+
+33
+00:03:27,280 --> 00:03:32,640
+where is thatthis sentence for it instead of it it
+
+34
+00:03:32,640 --> 00:03:38,600
+refers to what exams so we have to say what for
+
+35
+00:03:38,600 --> 00:03:45,180
+they or them them why them not they it is object
+
+36
+00:03:45,180 --> 00:03:49,280
+object what type of object look after the
+
+37
+00:03:49,280 --> 00:03:54,280
+preposition it is the object of the preposition it
+
+38
+00:03:54,280 --> 00:03:56,960
+is the object of the preposition thank you for
+
+39
+00:03:56,960 --> 00:04:02,720
+themyour yeah what's
+
+40
+00:04:02,720 --> 00:04:10,000
+that okay very good your exam your exam what type
+
+41
+00:04:10,000 --> 00:04:14,900
+of pronoun is your what do we call it my pen your
+
+42
+00:04:14,900 --> 00:04:20,780
+pen his pen her pen positive pronoun thank you
+
+43
+00:04:20,780 --> 00:04:24,900
+very much now look at the positive pronoun it is
+
+44
+00:04:24,900 --> 00:04:36,160
+followed by whatby a noun okay by a noun now again
+
+45
+00:04:36,160 --> 00:04:43,600
+go on yes please I thought bottoms spends most of
+
+46
+00:04:43,600 --> 00:04:48,660
+his time most of its time in the water rivers and
+
+47
+00:04:48,660 --> 00:04:52,580
+lakes it's without apostrophe it's okay this is
+
+48
+00:04:52,580 --> 00:04:58,010
+what without apostrophe like that it'sit's so
+
+49
+00:04:58,010 --> 00:05:02,770
+what's the difference between this word and this
+
+50
+00:05:02,770 --> 00:05:07,290
+word I have look it's and it's the same
+
+51
+00:05:07,290 --> 00:05:10,910
+pronunciation what's the difference between them
+
+52
+00:05:10,910 --> 00:05:17,570
+it is
+
+53
+00:05:17,570 --> 00:05:22,790
+or good it has it is or it has good and without
+
+54
+00:05:22,790 --> 00:05:23,550
+apostrophe
+
+55
+00:05:25,850 --> 00:05:30,930
+Okay thank you good next one please next one yeah
+
+56
+00:05:30,930 --> 00:05:41,470
+okay
+
+57
+00:05:41,470 --> 00:05:47,470
+now
+
+58
+00:05:47,470 --> 00:05:57,400
+again so where are the errors and me goodme now
+
+59
+00:05:57,400 --> 00:06:02,020
+why me not I speak
+
+60
+00:06:02,020 --> 00:06:07,420
+to مونة object of the preposition now if this is
+
+61
+00:06:07,420 --> 00:06:12,180
+an object okay مونة this should also be what
+
+62
+00:06:12,180 --> 00:06:17,680
+object I is a subject pronoun right it is used as
+
+63
+00:06:17,680 --> 00:06:25,720
+a subject yes please who is the speakerOkay for
+
+64
+00:06:25,720 --> 00:06:31,780
+our okay our so we don't need opinions right we
+
+65
+00:06:31,780 --> 00:06:36,980
+say for ours this is or for our opinions good this
+
+66
+00:06:36,980 --> 00:06:40,720
+is ours this is yours this is his and this is
+
+67
+00:06:40,720 --> 00:06:45,040
+theirs and so on thank you and finally number six
+
+68
+00:06:45,040 --> 00:06:50,540
+yes my parents asked to borrow my car because
+
+69
+00:06:50,540 --> 00:06:51,220
+there was
+
+70
+00:06:57,560 --> 00:07:03,040
+because just why but
+
+71
+00:07:03,040 --> 00:07:05,560
+we are not talking about the cars the pronoun
+
+72
+00:07:05,560 --> 00:07:09,220
+refers to what what does the pronoun refer to
+
+73
+00:07:09,220 --> 00:07:16,280
+again okay now they're what okay my friends okay
+
+74
+00:07:16,280 --> 00:07:19,560
+my friends so
+
+75
+00:07:23,070 --> 00:07:26,250
+one speaker .. who is the speaker .. yeah .. yeah
+
+76
+00:07:26,250 --> 00:07:34,870
+.. okay their car .. that's right without
+
+77
+00:07:34,870 --> 00:07:39,070
+apostrophe .. without apostrophe .. is that okay
+
+78
+00:07:39,070 --> 00:07:45,030
+.. she .. she couldn't get it .. now we are
+
+79
+00:07:45,030 --> 00:07:48,050
+talking .. look the pronoun .. this is called ..
+
+80
+00:07:48,050 --> 00:07:50,910
+it refers to the noun .. this noun .. this is
+
+81
+00:07:50,910 --> 00:07:57,110
+called the antecedentانتسيدانت ماذا يعني هذا؟ هل
+
+82
+00:07:57,110 --> 00:08:03,850
+يعني السيارة أو صديقي؟ لأنهم .. هم ماذا؟ أصدقائي
+
+83
+00:08:03,850 --> 00:08:11,070
+.. إذا .. إذا كنت ترغب في كتابة كلمة بدل الاسم،
+
+84
+00:08:11,070 --> 00:08:18,050
+ماذا يجب أن تكتب؟ لأن أصدقائي .. لأن
+
+85
+00:08:18,050 --> 00:08:22,820
+أصدقائي يسألونOkay to borrow my car because
+
+86
+00:08:22,820 --> 00:08:27,480
+there's was. So there refers to my friends. Now
+
+87
+00:08:27,480 --> 00:08:30,340
+there's .. who can use this word in a sentence?
+
+88
+00:08:30,920 --> 00:08:31,180
+Look.
+
+89
+00:08:35,100 --> 00:08:38,000
+Who can use it with apostrophe in a sentence?
+
+90
+00:08:38,180 --> 00:08:42,300
+Yeah. Very good. There is a laptop on the table.
+
+91
+00:08:44,060 --> 00:08:47,180
+Now let's start talking about pronouns.
+
+92
+00:09:11,570 --> 00:09:17,230
+personal pronouns they are divided into what
+
+93
+00:09:17,230 --> 00:09:22,730
+subject pronouns object pronouns possessive
+
+94
+00:09:22,730 --> 00:09:28,030
+adjectives pronouns now let's start by the first
+
+95
+00:09:28,030 --> 00:09:34,930
+groupI live in Gaza where is the subject I good
+
+96
+00:09:34,930 --> 00:09:39,610
+use you in a similar sentence yeah you are a
+
+97
+00:09:39,610 --> 00:09:43,310
+teacher where is the subject you you good use she
+
+98
+00:09:43,310 --> 00:09:47,990
+in a sentence yeah she's a good girl thank you
+
+99
+00:09:47,990 --> 00:09:53,710
+where is the subject she he yeah he's a student
+
+100
+00:09:53,710 --> 00:09:57,750
+good where is the subject he use it in a sentence
+
+101
+00:10:00,630 --> 00:10:04,930
+it is a nice cat where is the subject okay thank
+
+102
+00:10:04,930 --> 00:10:09,930
+you now so these they are called what subject
+
+103
+00:10:09,930 --> 00:10:14,170
+pronouns because they are used as the subject of
+
+104
+00:10:14,170 --> 00:10:18,380
+the sentence or they refer to the subjectthey
+
+105
+00:10:18,380 --> 00:10:23,840
+refer to the subject فاطمة is a good student she
+
+106
+00:10:23,840 --> 00:10:29,220
+is my sister she is my sister she refers to what
+
+107
+00:10:29,220 --> 00:10:34,100
+to فاطمة so they can be used as a subject or they
+
+108
+00:10:34,100 --> 00:10:37,140
+can refer to the subject now what about the other
+
+109
+00:10:37,140 --> 00:10:42,140
+group me my
+
+110
+00:10:42,140 --> 00:10:45,990
+little sister received meOkay my little sister
+
+111
+00:10:45,990 --> 00:10:52,590
+respects me very good now she respects
+
+112
+00:10:52,590 --> 00:11:01,610
+me good this is the object thank you yeah I'll
+
+113
+00:11:01,610 --> 00:11:07,190
+give you I'll give you good that's right thank you
+
+114
+00:11:07,190 --> 00:11:09,410
+yeah again
+
+115
+00:11:13,090 --> 00:11:18,330
+Okay this is a good example okay exams make me
+
+116
+00:11:18,330 --> 00:11:22,970
+okay make me nervous good thank you now you what
+
+117
+00:11:22,970 --> 00:11:25,450
+about you can you use it as a sentence as an
+
+118
+00:11:25,450 --> 00:11:28,950
+object makes
+
+119
+00:11:28,950 --> 00:11:35,770
+me she said me we want you a present you are right
+
+120
+00:11:35,770 --> 00:11:40,390
+that's right her all
+
+121
+00:11:40,390 --> 00:11:44,060
+the audience looking at herat her now looking at
+
+122
+00:11:44,060 --> 00:11:49,540
+her look at her here is preceded by what at okay
+
+123
+00:11:49,540 --> 00:11:53,840
+so it is the we call it object of the preposition
+
+124
+00:11:53,840 --> 00:11:58,260
+we have two types of object this is an object okay
+
+125
+00:11:58,260 --> 00:12:03,280
+but if i say for me for example it will be the
+
+126
+00:12:03,280 --> 00:12:08,340
+object of the prepositionOkay now if you say I saw
+
+127
+00:12:08,340 --> 00:12:16,400
+her yesterday I saw her yesterday I saw you I saw
+
+128
+00:12:16,400 --> 00:12:23,680
+her I saw him okay yesterday where
+
+129
+00:12:23,680 --> 00:12:29,800
+is the object okay thank you now what about the
+
+130
+00:12:29,800 --> 00:12:31,580
+other group possessive pronouns
+
+131
+00:12:35,420 --> 00:12:39,600
+yes please again
+
+132
+00:12:39,600 --> 00:12:49,760
+thank you this book is
+
+133
+00:12:49,760 --> 00:12:56,000
+mine very good this book is mine look
+
+134
+00:12:58,880 --> 00:13:02,640
+can I or shall I use a noun or a word after this
+
+135
+00:13:02,640 --> 00:13:07,760
+pronoun؟ no I cannot use okay is mine yeah use
+
+136
+00:13:07,760 --> 00:13:11,340
+yours in a sentence yeah this wallet is yours this
+
+137
+00:13:11,340 --> 00:13:14,020
+wallet is yours good where is it give it to me
+
+138
+00:13:14,020 --> 00:13:20,180
+okay this wallet is yours thank you the other one
+
+139
+00:13:20,180 --> 00:13:31,720
+hairs yes pleaseuse okay now we want this one this
+
+140
+00:13:31,720 --> 00:13:39,060
+laptop is hers okay okay فاطما is my sister this
+
+141
+00:13:39,060 --> 00:13:43,660
+laptop is hers okay is hers it is for her is his
+
+142
+00:13:43,660 --> 00:13:48,080
+and so on and the last group again possessive
+
+143
+00:13:48,080 --> 00:13:51,520
+adjective now so we have possessive pronouns and
+
+144
+00:13:51,520 --> 00:13:56,890
+possessive adjectives okay yes pleasethis is my
+
+145
+00:13:56,890 --> 00:14:05,870
+book look good this is this is my book now what's
+
+146
+00:14:05,870 --> 00:14:08,590
+the difference between the first group and the
+
+147
+00:14:08,590 --> 00:14:13,110
+second group look is mine and my book who can give
+
+148
+00:14:13,110 --> 00:14:19,050
+me the difference yeah this is my book followed by
+
+149
+00:14:19,050 --> 00:14:24,860
+a nouncannot be followed by a noun so a positive
+
+150
+00:14:24,860 --> 00:14:28,800
+adjective should always be followed by what a noun
+
+151
+00:14:28,800 --> 00:14:34,320
+adjectives like that can i say this is a red this
+
+152
+00:14:34,320 --> 00:14:38,200
+is a beautiful for example no this is a beautiful
+
+153
+00:14:38,200 --> 00:14:45,230
+flower okay it is a coldhas no meaning right it is
+
+154
+00:14:45,230 --> 00:14:51,130
+a cold weather it is a nice story and so on it is
+
+155
+00:14:51,130 --> 00:14:56,610
+an easy easy what easy exam and so on you know so
+
+156
+00:14:56,610 --> 00:15:00,050
+again adjectives should be followed by nouns and
+
+157
+00:15:00,050 --> 00:15:04,250
+these also pronouns should be followed by nouns so
+
+158
+00:15:04,250 --> 00:15:08,390
+we say this is my book your book his book her book
+
+159
+00:15:08,390 --> 00:15:15,080
+and so on now this group we used whatthe pronouns
+
+160
+00:15:15,080 --> 00:15:18,780
+are all in the singular form let's come to the
+
+161
+00:15:18,780 --> 00:15:24,020
+plural okay the same thing instead of saying I
+
+162
+00:15:24,020 --> 00:15:30,560
+yeah we are studying English grammar now very good
+
+163
+00:15:30,560 --> 00:15:36,080
+we are studying English grammar you you should
+
+164
+00:15:36,080 --> 00:15:41,820
+take care of yourself thank you I'll do good yeah
+
+165
+00:15:42,770 --> 00:15:45,610
+they are .. they are playing football they are
+
+166
+00:15:45,610 --> 00:15:49,630
+playing football good thank you very much okay now
+
+167
+00:15:49,630 --> 00:15:57,990
+us us yeah okay
+
+168
+00:15:57,990 --> 00:16:05,350
+the teacher told us a story about okay now you
+
+169
+00:16:05,350 --> 00:16:08,710
+they
+
+170
+00:16:08,710 --> 00:16:20,260
+visited usthey visited us we are visiting I will
+
+171
+00:16:20,260 --> 00:16:29,600
+visit you tomorrow good now them I'll
+
+172
+00:16:29,600 --> 00:16:34,960
+give them some advice thank you now this car is
+
+173
+00:16:35,740 --> 00:16:42,840
+ours okay this villa is yours okay this laptop is
+
+174
+00:16:42,840 --> 00:16:48,820
+theirs okay and we say this is our house this is
+
+175
+00:16:48,820 --> 00:16:55,320
+our university this is your book and this is their
+
+176
+00:16:55,320 --> 00:16:59,240
+their house their book and so on
+
+177
+00:17:05,690 --> 00:17:09,930
+So what do we come out from these pronouns؟ Yes,
+
+178
+00:17:10,010 --> 00:17:12,870
+can you talk, can you say something about these
+
+179
+00:17:12,870 --> 00:17:17,830
+pronouns؟ personal pronouns we have four groups
+
+180
+00:17:17,830 --> 00:17:21,590
+for it subject, object, possessive and possessive
+
+181
+00:17:21,590 --> 00:17:24,970
+pronoun and possessive adjectives we use it even
+
+182
+00:17:24,970 --> 00:17:29,750
+singular or plural good thank you now possessive
+
+183
+00:17:29,750 --> 00:17:32,030
+pronouns and adjectives what's the main difference
+
+184
+00:17:32,030 --> 00:17:35,570
+between them?what's the main difference يا خديجة؟
+
+185
+00:17:35,570 --> 00:17:40,430
+should be
+
+186
+00:17:40,430 --> 00:17:46,510
+followed by a noun okay
+
+187
+00:17:46,510 --> 00:17:53,330
+good now look at this sentence I read a book it
+
+188
+00:17:53,330 --> 00:17:59,700
+was good I read a book it was goodit refers to
+
+189
+00:17:59,700 --> 00:18:06,760
+book what book is called antecedent book is called
+
+190
+00:18:06,760 --> 00:18:13,520
+antecedent now what type of pronoun is it singular
+
+191
+00:18:13,520 --> 00:18:19,780
+subject okay it refers to the subject look I read
+
+192
+00:18:19,780 --> 00:18:27,740
+some booksthey were good now a pronoun is used
+
+193
+00:18:27,740 --> 00:18:32,340
+instead of what? instead of repeating I read some
+
+194
+00:18:32,340 --> 00:18:35,440
+books, the books were .. so I don't repeat,
+
+195
+00:18:35,620 --> 00:18:38,740
+repetition should be avoided in writing you know
+
+196
+00:18:40,210 --> 00:18:45,390
+أنا أستخدم نمو بدل نمو، يمكن أن يكون عملي، يمكن أن
+
+197
+00:18:45,390 --> 00:18:46,250
+يكون عملي، يمكن أن يكون عملي، يمكن أن يكون عملي،
+
+198
+00:18:46,250 --> 00:18:48,490
+يمكن أن يكون عملي، يمكن أن يكون عملي، يمكن أن تكون
+
+199
+00:18:48,490 --> 00:18:49,570
+عملي، يمكن أن تكون عملي، يمكن أن تكون عملي، يمكن
+
+200
+00:18:49,570 --> 00:18:50,070
+أن تكون عملي، يمكن أن تكون عملي، يمكن أن تكون
+
+201
+00:18:50,070 --> 00:18:50,090
+عملي، يمكن أن تكون عملي، يمكن أن تكون عملي، يمكن
+
+202
+00:18:50,090 --> 00:18:50,570
+عملي، يمكن أن تكون عملي، يمكن أن تكون عملي، يمكن
+
+203
+00:18:50,570 --> 00:18:55,570
+أن تكون عملي، يمكن أن تكون عملي، يمكن أن تكون
+
+204
+00:18:55,570 --> 00:19:03,830
+عملي، يمكن أن تكون عملي، يمكن
+
+205
+00:19:05,250 --> 00:19:09,770
+plural to refer to the plural okay thank you now
+
+206
+00:19:09,770 --> 00:19:16,210
+book and books yeah book and books they are called
+
+207
+00:19:16,210 --> 00:19:22,650
+antecedents antecedents this is Fatima she's my
+
+208
+00:19:22,650 --> 00:19:30,890
+sister Fatima is what antecedent now read this
+
+209
+00:19:30,890 --> 00:19:31,990
+point please
+
+210
+00:19:38,830 --> 00:19:44,410
+thank you singular to singular plural to plural I
+
+211
+00:19:44,410 --> 00:19:49,770
+think this is clear right no questions good now
+
+212
+00:19:49,770 --> 00:19:57,230
+look I like tea now when I say Fatima is my sister
+
+213
+00:19:57,230 --> 00:20:06,920
+Huda is my sisterI stated the subject clearly okay
+
+214
+00:20:06,920 --> 00:20:11,420
+when I say huda is my sister she's living there
+
+215
+00:20:11,420 --> 00:20:18,000
+she refers to huda so I mentioned her name okay so
+
+216
+00:20:18,000 --> 00:20:22,820
+you can understand what does she refer to but when
+
+217
+00:20:22,820 --> 00:20:29,740
+I begin with the pronoun I like tea you like teaI
+
+218
+00:20:29,740 --> 00:20:36,540
+like tea you like tea now is the antecedent now I
+
+219
+00:20:36,540 --> 00:20:41,960
+refers to what the speaker very good thank you
+
+220
+00:20:41,960 --> 00:20:49,750
+very much and you refers to whatthe person you are
+
+221
+00:20:49,750 --> 00:20:54,050
+talking to the person you are talking to now in
+
+222
+00:20:54,050 --> 00:20:58,690
+the previous sentences when i say this is a book
+
+223
+00:20:58,690 --> 00:21:03,630
+okay it is easy for example it refers to the book
+
+224
+00:21:03,630 --> 00:21:08,690
+it is refers to the antecedent the antecedent is
+
+225
+00:21:08,690 --> 00:21:12,570
+what clear yes is mentioned clearly you can
+
+226
+00:21:12,570 --> 00:21:17,670
+understand itمن السلسلة يمكنك أن تقرأها في السلسلة
+
+227
+00:21:17,670 --> 00:21:25,030
+ولكن الآن I يتعلق إلى أين هو الاتصال؟ ليس مذكرة
+
+228
+00:21:25,030 --> 00:21:30,870
+ولكن يمكن أن تفهمها أنت تعرف أن أنا أتحدث عن نفسي،
+
+229
+00:21:30,870 --> 00:21:34,290
+أنت تتحدث عن بعض الناس، أنا أتحدث أيضًا، لذلك
+
+230
+00:21:34,290 --> 00:21:41,990
+الاتصال هنا يمكن أن تفهمه، ليس مذكرة بشكل واضح،
+
+231
+00:21:41,990 --> 00:21:51,250
+لذلكالتحدث، هل تحب الطعام إلى الواحد؟ أنا أتكلم
+
+232
+00:21:51,250 --> 00:21:52,870
+أيضًا. حسنًا.
+
+233
+00:21:55,990 --> 00:22:01,050
+الآن، انظر إلى الفعل. نعم، قرر، أرجوك قرر الفعل.
+
+234
+00:22:01,810 --> 00:22:05,890
+جهاد لديه سيارة، يحرك إلى العمل. حسنًا، يحرك إلى
+
+235
+00:22:05,890 --> 00:22:11,020
+العمل.Now جهاد has a car. He drives to work. Where
+
+236
+00:22:11,020 --> 00:22:14,400
+is the subject in this sentence? جهاد. Where is
+
+237
+00:22:14,400 --> 00:22:19,360
+the object? A car. Now he drives to work. What
+
+238
+00:22:19,360 --> 00:22:23,570
+does he refer? Where is the antecedent?جهاد Now
+
+239
+00:22:23,570 --> 00:22:28,450
+this is what؟ a subject، this is a subject okay؟
+
+240
+00:22:28,450 --> 00:22:32,210
+Now in the other sentence, this is a subject, so
+
+241
+00:22:32,210 --> 00:22:36,850
+this pronoun, a subject pronoun is used as a
+
+242
+00:22:36,850 --> 00:22:41,730
+subject, right؟ it also refers to a subject Can
+
+243
+00:22:41,730 --> 00:22:45,250
+you give me an example like that? Give me an
+
+244
+00:22:45,250 --> 00:22:45,650
+example
+
+245
+00:22:50,210 --> 00:22:53,770
+marwa is absent she has a wedding very good thank
+
+246
+00:22:53,770 --> 00:22:59,430
+you marwa is she has and also she refers to marwa
+
+247
+00:22:59,430 --> 00:23:04,510
+that's nice now look at the other sentence jihad
+
+248
+00:23:04,510 --> 00:23:08,970
+works in my office where is the object
+
+249
+00:23:13,470 --> 00:23:19,410
+Jihad works in my office I know him I know him him
+
+250
+00:23:19,410 --> 00:23:24,250
+refers to what to jihad okay him refers to this is
+
+251
+00:23:24,250 --> 00:23:28,950
+the object of what of the verb this is the object
+
+252
+00:23:28,950 --> 00:23:34,350
+of the verb I know him okay but in this sentence I
+
+253
+00:23:34,350 --> 00:23:40,280
+talk to him every dayI talked to him him is an
+
+254
+00:23:40,280 --> 00:23:43,960
+object pronoun in this sentence after the
+
+255
+00:23:43,960 --> 00:23:47,300
+preposition it is called what object of the
+
+256
+00:23:47,300 --> 00:23:51,660
+preposition so we have two types of objects object
+
+257
+00:23:51,660 --> 00:23:56,260
+of the verb and object of the preposition the
+
+258
+00:23:56,260 --> 00:23:59,440
+object of the verb is mentioned as you see after
+
+259
+00:23:59,440 --> 00:24:02,320
+the verb and the object of the preposition is
+
+260
+00:24:02,320 --> 00:24:04,920
+mentioned after the preposition
+
+261
+00:24:08,090 --> 00:24:11,290
+look at this sentence would you read please read
+
+262
+00:24:11,290 --> 00:24:17,070
+the sentence okay that book is hairs
+
+263
+00:24:17,070 --> 00:24:22,510
+okay good go on okay
+
+264
+00:24:22,510 --> 00:24:27,650
+yours is over there thank you now hairs and yours
+
+265
+00:24:27,650 --> 00:24:30,950
+we called them what or they are called what
+
+266
+00:24:31,980 --> 00:24:35,900
+possessive pronouns thank you yeah are not
+
+267
+00:24:35,900 --> 00:24:39,040
+followed by what a noun they should not be
+
+268
+00:24:39,040 --> 00:24:41,520
+followed by a noun if you look at this sentence
+
+269
+00:24:41,520 --> 00:24:45,340
+shall i use a noun after this one no shall i use a
+
+270
+00:24:45,340 --> 00:24:49,420
+noun here no it is not used so again these
+
+271
+00:24:49,420 --> 00:24:52,760
+pronouns are not followed immediately by a noun
+
+272
+00:24:52,760 --> 00:24:59,500
+they stand alone don't say that book is hers okay
+
+273
+00:24:59,500 --> 00:25:05,180
+don't saythis is hers you know that book is yours
+
+274
+00:25:05,180 --> 00:25:09,800
+is over there hairs should be written like that
+
+275
+00:25:09,800 --> 00:25:15,240
+okay without apostrophe very goodsome students are
+
+276
+00:25:15,240 --> 00:25:18,860
+fond of writing the apostrophe just they write
+
+277
+00:25:18,860 --> 00:25:21,840
+apostrophe here and apostrophe there you know
+
+278
+00:25:21,840 --> 00:25:25,380
+apostrophe is good when needed if you need it
+
+279
+00:25:25,380 --> 00:25:29,580
+write it if it is not needed you should avoid it
+
+280
+00:25:29,580 --> 00:25:33,360
+okay so in this case it is not needed in these
+
+281
+00:25:33,360 --> 00:25:37,040
+pronouns we say hers without apostrophe and yours
+
+282
+00:25:37,040 --> 00:25:42,960
+without apostrophe now
+
+283
+00:25:44,480 --> 00:25:50,100
+look hair book, your book what type of pronouns
+
+284
+00:25:50,100 --> 00:25:56,540
+are these hair and your possessive adjectives okay
+
+285
+00:25:56,540 --> 00:26:01,920
+can they stand alone no they are like the
+
+286
+00:26:01,920 --> 00:26:05,480
+adjectives they cannot stand alone they should be
+
+287
+00:26:05,480 --> 00:26:08,220
+followed by what by nouns good
+
+288
+00:26:12,560 --> 00:26:19,740
+now read the sentence please yeah
+
+289
+00:26:19,740 --> 00:26:24,480
+a bird uses its wings to fly its wings what type
+
+290
+00:26:24,480 --> 00:26:30,140
+of pronoun is its okay now shall we use an
+
+291
+00:26:30,140 --> 00:26:34,200
+apostrophe here no it is not accepted to write it
+
+292
+00:26:34,200 --> 00:26:39,260
+with apostrophe this isincorrect okay with
+
+293
+00:26:39,260 --> 00:26:43,160
+apostrophe it is not accepted now look at this
+
+294
+00:26:43,160 --> 00:26:50,460
+sentence it it's been in business since 1933 it's
+
+295
+00:26:50,460 --> 00:26:58,180
+been it has been it has been so again it has an
+
+296
+00:26:58,180 --> 00:27:03,640
+apostrophe or you knowSo again as we said look
+
+297
+00:27:03,640 --> 00:27:07,840
+it's called today it's called today the apostrophe
+
+298
+00:27:07,840 --> 00:27:10,660
+is used with it in two cases
+
+299
+00:27:13,100 --> 00:27:19,280
+in abbreviations right now is is abbreviated there
+
+300
+00:27:19,280 --> 00:27:24,420
+instead of writing it is we say it's to show that
+
+301
+00:27:24,420 --> 00:27:28,180
+something is omitted we don't write a full is a
+
+302
+00:27:28,180 --> 00:27:32,600
+complete is so instead of writing it is okay we
+
+303
+00:27:32,600 --> 00:27:36,420
+omit a part of the verb is and write apostrophe to
+
+304
+00:27:36,420 --> 00:27:40,660
+show that there is omission something is deleted
+
+305
+00:27:41,650 --> 00:27:48,370
+والآخر بدل من كتابة لديه .. نكتب الـ apostrophe،
+
+306
+00:27:48,370 --> 00:27:52,950
+هذا صحيح وكما
+
+307
+00:27:52,950 --> 00:27:56,350
+تعلمين، هذه منطقة خطأ، حتى المتحدثين الوطنيين
+
+308
+00:27:56,350 --> 00:27:59,490
+يفعلوا بعض الخطوات في هذه المنطقة، انظروا إلى هذه
+
+309
+00:27:59,490 --> 00:28:06,390
+التعليقات، السلسلة الأولى اكتشف الاسم الخاص بهم
+
+310
+00:28:06,390 --> 00:28:10,210
+ومقابلاتهم، من يريد أن يأتي إلى البرج؟
+
+311
+00:28:15,480 --> 00:28:28,140
+come please okay
+
+312
+00:28:28,140 --> 00:28:31,460
+they
+
+313
+00:28:31,460 --> 00:28:36,320
+okay now where is the pronoun and where is the
+
+314
+00:28:36,320 --> 00:28:42,900
+antecedentno no no just underline .. just write ..
+
+315
+00:28:42,900 --> 00:28:46,840
+draw a circle around the antecedent draw a circle
+
+316
+00:28:46,840 --> 00:28:50,040
+and underline the pronoun okay this is the
+
+317
+00:28:50,040 --> 00:28:54,040
+antecedent good and the pronouns thank you next
+
+318
+00:28:54,040 --> 00:28:59,420
+one come ياسمين the teacher graded a student's
+
+319
+00:28:59,420 --> 00:29:02,160
+paper last night she returned them during class
+
+320
+00:29:02,160 --> 00:29:07,080
+today the teacher's antecedent
+
+321
+00:29:09,680 --> 00:29:17,480
+شكرا، الرقم أربعة، نعم، أتركي أرجوك
+
+322
+00:29:17,480 --> 00:29:23,140
+ناسي أخدت أفل معها للعمل، و أكلت أكتر من أكتر من
+
+323
+00:29:23,140 --> 00:29:23,340
+أكتر من أكتر من أكتر من أكتر من أكتر من أكتر من
+
+324
+00:29:23,340 --> 00:29:24,380
+أكتر من أكتر من أكتر من أكتر من أكتر من أكتر من
+
+325
+00:29:24,380 --> 00:29:26,860
+أكتر من أكتر من أكتر من أكتر من أكتر من أكتر من
+
+326
+00:29:26,860 --> 00:29:26,960
+أكتر من أكتر من أكتر من أكتر من أكتر من أكتر من
+
+327
+00:29:26,960 --> 00:29:27,260
+أكتر من أكتر من أكتر من أكتر من أكتر من أكتر من
+
+328
+00:29:27,260 --> 00:29:32,000
+أكتر من أكتر من أكتر من أكتر من
+
+329
+00:29:32,000 --> 00:29:35,700
+أكjust a minute look at the first sentence Nancy
+
+330
+00:29:35,700 --> 00:29:38,380
+took an apple with her look at the first sentence
+
+331
+00:29:38,380 --> 00:29:42,560
+okay this is the pronoun right it refers to Nancy
+
+332
+00:29:42,560 --> 00:29:50,620
+and she is it a pronoun or antecedent a pronoun so
+
+333
+00:29:50,620 --> 00:29:55,020
+underline it we circle the antecedent thank you
+
+334
+00:29:55,020 --> 00:29:58,880
+just a minute just a minute she did not finish
+
+335
+00:29:58,880 --> 00:30:00,460
+okay
+
+336
+00:30:02,420 --> 00:30:07,520
+yeah she ate it yeah it refers to apple good so
+
+337
+00:30:07,520 --> 00:30:11,640
+underline it and circle okay yes what did you want
+
+338
+00:30:11,640 --> 00:30:16,000
+to say she
+
+339
+00:30:16,000 --> 00:30:20,420
+returned
+
+340
+00:30:20,420 --> 00:30:24,140
+them the teacher regretted the students papers she
+
+341
+00:30:24,140 --> 00:30:27,440
+you are right thank you okay them refers to
+
+342
+00:30:27,440 --> 00:30:31,240
+students papers this is another one okay good
+
+343
+00:30:33,920 --> 00:30:43,840
+thank you next one yes come please
+
+344
+00:30:43,840 --> 00:30:50,520
+thank
+
+345
+00:30:50,520 --> 00:30:53,920
+you
+
+346
+00:30:53,920 --> 00:30:59,140
+number six come
+
+347
+00:30:59,140 --> 00:30:59,540
+please
+
+348
+00:31:05,610 --> 00:31:09,070
+الطيبة يوري اسمها
+
+349
+00:31:09,070 --> 00:31:16,450
+my bully alice هي مستقلة جدا، لم تتعامل مع يوري،
+
+350
+00:31:16,450 --> 00:31:22,510
+والحيوانات تتعامل معه بمجرد ذلك، يحبون أن تقابله
+
+351
+00:31:22,510 --> 00:31:29,350
+أولا، الطيبة يوري اسمها ..
+
+352
+00:31:29,960 --> 00:31:33,340
+yuri's cat this is the antecedent okay good where
+
+353
+00:31:33,340 --> 00:31:37,860
+is the pronoun which refers to it she now you look
+
+354
+00:31:37,860 --> 00:31:41,860
+with the cat if the gender if the sex of the
+
+355
+00:31:41,860 --> 00:31:45,260
+animal male or female is known and is given a name
+
+356
+00:31:45,260 --> 00:31:49,940
+they say he or she okay this is something normal
+
+357
+00:31:49,940 --> 00:31:56,020
+go on she never offends yuri she also for yuri's
+
+358
+00:31:56,020 --> 00:31:58,600
+cat yes
+
+359
+00:32:00,710 --> 00:32:04,310
+his dogs refers
+
+360
+00:32:04,310 --> 00:32:09,090
+to يوري's cats
+
+361
+00:32:09,090 --> 00:32:19,050
+no to يوري not to cat his dogs يوري's dogs on the
+
+362
+00:32:19,050 --> 00:32:28,750
+other hand obey him to يوري they like to please
+
+363
+00:32:28,750 --> 00:32:37,120
+him they dogsand him his dogs him yuri him yuri
+
+364
+00:32:37,120 --> 00:32:48,540
+good thank you very much check
+
+365
+00:32:48,540 --> 00:32:52,680
+your answers make sure that you got the right
+
+366
+00:32:52,680 --> 00:32:55,080
+answers you have the right answers
+
+367
+00:33:20,920 --> 00:33:30,460
+let's move to the other exercise read
+
+368
+00:33:30,460 --> 00:33:36,760
+what does he want he is
+
+369
+00:33:36,760 --> 00:33:39,500
+giving us two options
+
+370
+00:33:42,070 --> 00:33:46,150
+not a number of native English speakers commonly
+
+371
+00:33:46,150 --> 00:33:49,490
+use subject pronouns after and even when the
+
+372
+00:33:49,490 --> 00:33:52,450
+grammatically correct choice is an object pronoun
+
+373
+00:33:52,450 --> 00:33:55,650
+thank you now what does that mean what do we
+
+374
+00:33:55,650 --> 00:34:00,270
+understand okay what do we understand in the first
+
+375
+00:34:00,270 --> 00:34:05,190
+sentence a number he saysa number of native
+
+376
+00:34:05,190 --> 00:34:09,170
+speakers commonly use as subject pronouns after
+
+377
+00:34:09,170 --> 00:34:13,550
+and even when the grammatically correct choice is
+
+378
+00:34:13,550 --> 00:34:17,470
+an object to pronounce what does that mean؟ like
+
+379
+00:34:17,470 --> 00:34:20,570
+in the first sentence the correct answer is an
+
+380
+00:34:20,570 --> 00:34:24,190
+object to pronoun me but they may use and I that's
+
+381
+00:34:24,190 --> 00:34:28,190
+right yeah they use I but we should say what؟ memy
+
+382
+00:34:28,190 --> 00:34:34,230
+parents always read bedtime stories to my sister
+
+383
+00:34:34,230 --> 00:34:41,550
+and .. and I or and me and why؟ why me not I؟ okay
+
+384
+00:34:41,550 --> 00:34:45,050
+it is object of the proposition that's right but
+
+385
+00:34:45,050 --> 00:34:50,590
+native speakers usually use what؟ okay good so
+
+386
+00:34:50,590 --> 00:34:54,990
+number two .. who wants to make number two?
+
+387
+00:34:57,860 --> 00:35:02,500
+يه؟ who wants to write to answer number two؟ يه
+
+388
+00:35:02,500 --> 00:35:09,080
+كم؟ كم يا سمين؟
+
+389
+00:35:09,080 --> 00:35:16,380
+do it just between you and me I think Mr. Lucas is
+
+390
+00:35:16,380 --> 00:35:19,860
+going to lose هجرة good thank you between you and
+
+391
+00:35:19,860 --> 00:35:21,980
+me يه كم؟
+
+392
+00:35:31,650 --> 00:35:42,030
+to him good thank you I need to tell you and thank
+
+393
+00:35:42,030 --> 00:35:51,110
+you good yes please
+
+394
+00:35:51,110 --> 00:35:51,630
+come
+
+395
+00:35:57,870 --> 00:36:00,650
+السيد ميزيكي يحتاج إلى أن يعرف الطريقة التي
+
+396
+00:36:00,650 --> 00:36:08,850
+سأخبرها الشيخ شانج و هيرد الطريقة انا
+
+397
+00:36:08,850 --> 00:36:18,890
+قاعدة طبعا حسنا ماذا فعلت؟ انا سأخبر شانج و هيرد
+
+398
+00:36:18,890 --> 00:36:20,990
+حسنا شكرا و أخيرا
+
+399
+00:36:33,840 --> 00:36:44,760
+السيدة؟ شكرا اتفقنا
+
+400
+00:36:44,760 --> 00:36:48,560
+بإجابتك مرة أخرى، اتفقنا بإجابتك مرة أخرى،
+
+401
+00:37:12,220 --> 00:37:16,840
+Now look at the new exercise complete the
+
+402
+00:37:16,840 --> 00:37:21,340
+sentences in each situation with pronoun for the
+
+403
+00:37:21,340 --> 00:37:24,640
+word in italic situation for example situation one
+
+404
+00:37:24,640 --> 00:37:29,380
+there is Sarah I need to go to talk to her
+
+405
+00:37:35,330 --> 00:37:40,110
+I need to go talk to her she and I good she and I
+
+406
+00:37:40,110 --> 00:37:43,310
+thank you number three quickly this is an easy
+
+407
+00:37:43,310 --> 00:37:46,990
+exercise yeah come please I went to elementary
+
+408
+00:37:46,990 --> 00:37:54,150
+school
+
+409
+00:37:54,150 --> 00:37:59,670
+with her brother and I and her and her yes
+
+410
+00:37:59,670 --> 00:38:02,590
+together it means that we went together to her
+
+411
+00:38:02,590 --> 00:38:06,430
+brother and herI went with her okay I went with
+
+412
+00:38:06,430 --> 00:38:12,810
+her brother and her okay yeah come please next one
+
+413
+00:38:12,810 --> 00:38:23,050
+number four good
+
+414
+00:38:23,050 --> 00:38:26,850
+thank you تفضلي
+
+415
+00:38:32,510 --> 00:38:40,390
+هي تتزوج في الشهر القادم قبل
+
+416
+00:38:40,390 --> 00:38:42,190
+انتشار قبل انتشار قبل انتشار قبل انتشار قبل انتشار
+
+417
+00:38:42,190 --> 00:38:43,030
+قبل انتشار قبل انتشار قبل انتشار قبل انتشار قبل
+
+418
+00:38:43,030 --> 00:38:44,270
+انتشار قبل انتشار قبل انتشار قبل انتشار قبل انتشار
+
+419
+00:38:44,270 --> 00:38:47,290
+قبل انتشار قبل انتشار قبل انتشار قبل انتشار قبل
+
+420
+00:38:47,290 --> 00:38:48,750
+انتشار قبل انتشار قبل انتشار قبل انتشار قبل انتشار
+
+421
+00:38:48,750 --> 00:38:50,850
+قبل انتشار قبل انتشار قبل انتشار قبل انتشار قبل
+
+422
+00:38:50,850 --> 00:38:51,270
+انتشار قبل انتشار قبل انتشار قبل انتشار قبل انتشار
+
+423
+00:38:51,270 --> 00:38:56,150
+قبل انتشار قبل انتشار قبل انتشار ق
+
+424
+00:39:04,390 --> 00:39:10,390
+come again please being with her is a lot of fun
+
+425
+00:39:10,390 --> 00:39:17,510
+we laugh a lot thank you thank you yeah come
+
+426
+00:39:17,510 --> 00:39:27,790
+please she
+
+427
+00:39:27,790 --> 00:39:32,010
+has a good time with her friends very good
+
+428
+00:39:35,690 --> 00:39:40,170
+she always has a good time with her friends
+
+429
+00:39:40,170 --> 00:39:45,590
+situation two I'm not feeling well I think I'd
+
+430
+00:39:45,590 --> 00:39:54,850
+better stay at home today okay my friends and come
+
+431
+00:39:54,850 --> 00:40:01,190
+yes come let she come my friends and I
+
+432
+00:40:05,500 --> 00:40:11,840
+our local bank today clean the other words clean
+
+433
+00:40:11,840 --> 00:40:15,820
+them please okay can you do the other one number
+
+434
+00:40:15,820 --> 00:40:27,940
+nine read it and do it try it try number nine okay
+
+435
+00:40:27,940 --> 00:40:33,970
+thank you goodmy friends and me thank you number
+
+436
+00:40:33,970 --> 00:40:46,410
+ten فضلي come my friend
+
+437
+00:40:46,410 --> 00:40:51,130
+will have to go without me thank you do the other
+
+438
+00:40:51,130 --> 00:40:56,500
+one eleven read it I'd better I'd better callmy
+
+439
+00:40:56,500 --> 00:41:01,680
+friend's son thank you good and finally the last
+
+440
+00:41:01,680 --> 00:41:08,120
+one for today noor you
+
+441
+00:41:08,120 --> 00:41:12,700
+did enough today thank you very much you could I
+
+442
+00:41:12,700 --> 00:41:20,520
+use your cell phone I don't have it I don't
+
+443
+00:41:20,520 --> 00:41:25,510
+havemine with me okay I don't have my phone or my
+
+444
+00:41:25,510 --> 00:41:37,470
+mine I don't have mine with me thank you thank
+
+445
+00:41:37,470 --> 00:41:38,110
+you very much
+
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/L0A1ZAn1Sro_raw.json b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/L0A1ZAn1Sro_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..c0a02bb01e5f4e1e2ce5321c25896d5ff0253e59
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/L0A1ZAn1Sro_raw.json
@@ -0,0 +1 @@
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He drives to work. Where is the subject in this sentence? جهاد. Where is the object? A car. Now he drives to work. What does he refer? 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709, 291, 727, 286, 764, 428, 2815, 2593, 286, 500, 380, 362, 309, 286, 500, 380, 362], "avg_logprob": -0.3037347444673864, "compression_ratio": 1.4827586206896552, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 2456.02, "end": 2456.5, "word": "my", "probability": 0.411865234375}, {"start": 2456.5, "end": 2458.24, "word": " friend's", "probability": 0.4931640625}, {"start": 2458.24, "end": 2458.5, "word": " son", "probability": 0.87744140625}, {"start": 2458.5, "end": 2458.86, "word": " thank", "probability": 0.58837890625}, {"start": 2458.86, "end": 2459.24, "word": " you", "probability": 0.96630859375}, {"start": 2459.24, "end": 2459.82, "word": " good", "probability": 0.352294921875}, {"start": 2459.82, "end": 2460.26, "word": " and", "probability": 0.83935546875}, {"start": 2460.26, "end": 2461.08, "word": " finally", "probability": 0.91064453125}, {"start": 2461.08, "end": 2461.34, "word": " the", "probability": 0.84716796875}, {"start": 2461.34, "end": 2461.68, "word": " last", "probability": 0.892578125}, {"start": 2461.68, "end": 2462.22, "word": " one", "probability": 0.95654296875}, {"start": 2462.22, "end": 2462.72, "word": " for", "probability": 0.96826171875}, {"start": 2462.72, "end": 2463.18, "word": " today", "probability": 0.8408203125}, {"start": 2463.18, "end": 2464.16, "word": " noor", "probability": 0.554443359375}, {"start": 2464.16, "end": 2468.12, "word": " you", "probability": 0.865234375}, {"start": 2468.12, "end": 2468.32, "word": " did", "probability": 0.96728515625}, {"start": 2468.32, "end": 2468.58, "word": " enough", "probability": 0.88037109375}, {"start": 2468.58, "end": 2468.84, "word": " today", "probability": 0.83251953125}, {"start": 2468.84, "end": 2469.08, "word": " thank", "probability": 0.83203125}, {"start": 2469.08, "end": 2469.2, "word": " you", "probability": 0.96484375}, {"start": 2469.2, "end": 2469.4, "word": " very", "probability": 0.900390625}, {"start": 2469.4, "end": 2469.9, "word": " much", "probability": 0.92578125}, {"start": 2469.9, "end": 2471.12, "word": " you", "probability": 0.285400390625}, {"start": 2471.12, "end": 2472.5, "word": " could", "probability": 0.7607421875}, {"start": 2472.5, "end": 2472.7, "word": " I", "probability": 0.6669921875}, {"start": 2472.7, "end": 2473.0, "word": " use", "probability": 0.89111328125}, {"start": 2473.0, "end": 2473.24, "word": " your", "probability": 0.900390625}, {"start": 2473.24, "end": 2473.5, "word": " cell", "probability": 0.44970703125}, {"start": 2473.5, "end": 2473.74, "word": " phone", "probability": 0.939453125}, {"start": 2473.74, "end": 2473.96, "word": " I", "probability": 0.470458984375}, {"start": 2473.96, "end": 2474.2, "word": " don't", "probability": 0.96044921875}, {"start": 2474.2, "end": 2474.56, "word": " have", "probability": 0.96142578125}, {"start": 2474.56, "end": 2475.92, "word": " it", "probability": 0.962890625}, {"start": 2475.92, "end": 2477.16, "word": " I", "probability": 0.62060546875}, {"start": 2477.16, "end": 2480.52, "word": " don't", "probability": 0.981689453125}, {"start": 2480.52, "end": 2480.92, "word": " have", "probability": 0.96142578125}], "temperature": 1.0}, {"id": 90, "seek": 249811, "start": 2481.75, "end": 2498.11, "text": "mine with me okay I don't have my phone or my mine I don't have mine with me thank you thank you very much", "tokens": [76, 533, 365, 385, 1392, 286, 500, 380, 362, 452, 2593, 420, 452, 3892, 286, 500, 380, 362, 3892, 365, 385, 1309, 291, 1309, 291, 588, 709], "avg_logprob": -0.26967075041362215, "compression_ratio": 1.394736842105263, "no_speech_prob": 7.152557373046875e-07, "words": [{"start": 2481.75, "end": 2482.39, "word": "mine", "probability": 0.5460205078125}, {"start": 2482.39, "end": 2482.73, "word": " with", "probability": 0.8154296875}, {"start": 2482.73, "end": 2482.97, "word": " me", "probability": 0.9775390625}, {"start": 2482.97, "end": 2483.21, "word": " okay", "probability": 0.3564453125}, {"start": 2483.21, "end": 2483.45, "word": " I", "probability": 0.38525390625}, {"start": 2483.45, "end": 2483.75, "word": " don't", "probability": 0.95947265625}, {"start": 2483.75, "end": 2484.03, "word": " have", "probability": 0.96875}, {"start": 2484.03, "end": 2484.35, "word": " my", "probability": 0.9638671875}, {"start": 2484.35, "end": 2484.83, "word": " phone", "probability": 0.96044921875}, {"start": 2484.83, "end": 2485.09, "word": " or", "probability": 0.8369140625}, {"start": 2485.09, "end": 2485.51, "word": " my", "probability": 0.8505859375}, {"start": 2485.51, "end": 2486.47, "word": " mine", "probability": 0.5048828125}, {"start": 2486.47, "end": 2486.67, "word": " I", "probability": 0.481201171875}, {"start": 2486.67, "end": 2486.93, "word": " don't", "probability": 0.978271484375}, {"start": 2486.93, "end": 2487.23, "word": " have", "probability": 0.96875}, {"start": 2487.23, "end": 2487.79, "word": " mine", "probability": 0.91552734375}, {"start": 2487.79, "end": 2488.71, "word": " with", "probability": 0.87451171875}, {"start": 2488.71, "end": 2489.91, "word": " me", "probability": 0.96240234375}, {"start": 2489.91, "end": 2491.01, "word": " thank", "probability": 0.7763671875}, {"start": 2491.01, "end": 2491.35, "word": " you", "probability": 0.966796875}, {"start": 2491.35, "end": 2497.47, "word": " thank", "probability": 0.8251953125}, {"start": 2497.47, "end": 2497.59, "word": " you", "probability": 0.96875}, {"start": 2497.59, "end": 2497.79, "word": " very", "probability": 0.8984375}, {"start": 2497.79, "end": 2498.11, "word": " much", "probability": 0.9326171875}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2499.396, "duration_after_vad": 2284.6274999999914}
\ No newline at end of file
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/L0A1ZAn1Sro_raw.srt b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/L0A1ZAn1Sro_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..f90b324c1695d35a9d23600499afb059c8e23639
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/L0A1ZAn1Sro_raw.srt
@@ -0,0 +1,1784 @@
+1
+00:00:21,040 --> 00:00:26,920
+good morning to you all how are you again I'm fine
+
+2
+00:00:26,920 --> 00:00:30,240
+thank you but I'm not having an exam today you are
+
+3
+00:00:30,240 --> 00:00:34,000
+having exams don't worry about the exams think
+
+4
+00:00:34,000 --> 00:00:38,120
+nothing of that okay be with the grammar now can
+
+5
+00:00:38,120 --> 00:00:40,400
+you give me a sentence in English any sentence
+
+6
+00:00:40,400 --> 00:00:45,580
+think of a sentence I am
+
+7
+00:00:48,350 --> 00:00:53,310
+an Arab girl thank you very much I am the sentence
+
+8
+00:00:53,310 --> 00:01:01,510
+included I am okay Arab girl she started with I
+
+9
+00:01:01,510 --> 00:01:11,470
+what part of speech is I okay it is a pronoun it
+
+10
+00:01:11,470 --> 00:01:14,650
+is a subject good it is a subject it is a pronoun
+
+11
+00:01:15,360 --> 00:01:21,280
+الأن الـ Pronouns يستخدمون كثيرًا في إصلاح الفرصة
+
+12
+00:01:21,280 --> 00:01:26,980
+الإنقليزية هم محتاجين كثيرًا لإصلاح الفرصة ما هي
+
+13
+00:01:26,980 --> 00:01:31,880
+الـ Pronouns؟ ما هي أشكال الـ Pronouns؟ كيف نستخدم
+
+14
+00:01:31,880 --> 00:01:39,780
+الـ Pronouns؟ هذا ما سنتحدث عنه ولكن أولًا نبدأ
+
+15
+00:01:55,510 --> 00:02:00,190
+لنبدأ من هذه التعليمات، قم بقراءة السلسلة الأولى
+
+16
+00:02:00,190 --> 00:02:05,290
+أرجوك انا و انا أشترينا الطعام الاندي في المطعم،
+
+17
+00:02:05,290 --> 00:02:09,110
+لم أكن غاضبا جدا لكن انا أكلت أكتر منهم انا أكلت
+
+18
+00:02:09,110 --> 00:02:17,690
+أكتر منهم، اشترينا ماذا؟ طعام، و لم أكن غاضبا جدا
+
+19
+00:02:17,690 --> 00:02:21,910
+لكن انا أكلت أكتر منهم، ماذا تفكر في السلسلة؟ أكتر
+
+20
+00:02:21,910 --> 00:02:24,710
+من الـit، لماذا ليس الـthem؟
+
+21
+00:02:27,250 --> 00:02:32,570
+because it is a non count noun for the non count
+
+22
+00:02:32,570 --> 00:02:37,470
+nouns we use what singular verb very good we say
+
+23
+00:02:37,470 --> 00:02:42,570
+food is right news is okay thank you so this
+
+24
+00:02:42,570 --> 00:02:46,490
+should be what this should be instead of it of
+
+25
+00:02:46,490 --> 00:02:49,570
+them we say it good would you read the other
+
+26
+00:02:49,570 --> 00:02:52,950
+sentence please yeah when we were in school my
+
+27
+00:02:52,950 --> 00:02:55,370
+sister and me used to play tennis
+
+28
+00:03:01,240 --> 00:03:07,160
+my sister and I thank you my sister and I good
+
+29
+00:03:07,160 --> 00:03:10,440
+read
+
+30
+00:03:10,440 --> 00:03:13,800
+the other sentence yes please if you want to pass
+
+31
+00:03:13,800 --> 00:03:18,260
+your exams you had better study very hard for it
+
+32
+00:03:18,260 --> 00:03:27,280
+and for them okay so exams exams
+
+33
+00:03:27,280 --> 00:03:32,640
+where is thatthis sentence for it instead of it it
+
+34
+00:03:32,640 --> 00:03:38,600
+refers to what exams so we have to say what for
+
+35
+00:03:38,600 --> 00:03:45,180
+they or them them why them not they it is object
+
+36
+00:03:45,180 --> 00:03:49,280
+object what type of object look after the
+
+37
+00:03:49,280 --> 00:03:54,280
+preposition it is the object of the preposition it
+
+38
+00:03:54,280 --> 00:03:56,960
+is the object of the preposition thank you for
+
+39
+00:03:56,960 --> 00:04:02,720
+themyour yeah what's
+
+40
+00:04:02,720 --> 00:04:10,000
+that okay very good your exam your exam what type
+
+41
+00:04:10,000 --> 00:04:14,900
+of pronoun is your what do we call it my pen your
+
+42
+00:04:14,900 --> 00:04:20,780
+pen his pen her pen positive pronoun thank you
+
+43
+00:04:20,780 --> 00:04:24,900
+very much now look at the positive pronoun it is
+
+44
+00:04:24,900 --> 00:04:36,160
+followed by whatby a noun okay by a noun now again
+
+45
+00:04:36,160 --> 00:04:43,600
+go on yes please I thought bottoms spends most of
+
+46
+00:04:43,600 --> 00:04:48,660
+his time most of its time in the water rivers and
+
+47
+00:04:48,660 --> 00:04:52,580
+lakes it's without apostrophe it's okay this is
+
+48
+00:04:52,580 --> 00:04:58,010
+what without apostrophe like that it'sit's so
+
+49
+00:04:58,010 --> 00:05:02,770
+what's the difference between this word and this
+
+50
+00:05:02,770 --> 00:05:07,290
+word I have look it's and it's the same
+
+51
+00:05:07,290 --> 00:05:10,910
+pronunciation what's the difference between them
+
+52
+00:05:10,910 --> 00:05:17,570
+it is
+
+53
+00:05:17,570 --> 00:05:22,790
+or good it has it is or it has good and without
+
+54
+00:05:22,790 --> 00:05:23,550
+apostrophe
+
+55
+00:05:25,850 --> 00:05:30,930
+Okay thank you good next one please next one yeah
+
+56
+00:05:30,930 --> 00:05:41,470
+okay
+
+57
+00:05:41,470 --> 00:05:47,470
+now
+
+58
+00:05:47,470 --> 00:05:57,400
+again so where are the errors and me goodme now
+
+59
+00:05:57,400 --> 00:06:02,020
+why me not I speak
+
+60
+00:06:02,020 --> 00:06:07,420
+to مونة object of the preposition now if this is
+
+61
+00:06:07,420 --> 00:06:12,180
+an object okay مونة this should also be what
+
+62
+00:06:12,180 --> 00:06:17,680
+object I is a subject pronoun right it is used as
+
+63
+00:06:17,680 --> 00:06:25,720
+a subject yes please who is the speakerOkay for
+
+64
+00:06:25,720 --> 00:06:31,780
+our okay our so we don't need opinions right we
+
+65
+00:06:31,780 --> 00:06:36,980
+say for ours this is or for our opinions good this
+
+66
+00:06:36,980 --> 00:06:40,720
+is ours this is yours this is his and this is
+
+67
+00:06:40,720 --> 00:06:45,040
+theirs and so on thank you and finally number six
+
+68
+00:06:45,040 --> 00:06:50,540
+yes my parents asked to borrow my car because
+
+69
+00:06:50,540 --> 00:06:51,220
+there was
+
+70
+00:06:57,560 --> 00:07:03,040
+because just why but
+
+71
+00:07:03,040 --> 00:07:05,560
+we are not talking about the cars the pronoun
+
+72
+00:07:05,560 --> 00:07:09,220
+refers to what what does the pronoun refer to
+
+73
+00:07:09,220 --> 00:07:16,280
+again okay now they're what okay my friends okay
+
+74
+00:07:16,280 --> 00:07:19,560
+my friends so
+
+75
+00:07:23,070 --> 00:07:26,250
+one speaker .. who is the speaker .. yeah .. yeah
+
+76
+00:07:26,250 --> 00:07:34,870
+.. okay their car .. that's right without
+
+77
+00:07:34,870 --> 00:07:39,070
+apostrophe .. without apostrophe .. is that okay
+
+78
+00:07:39,070 --> 00:07:45,030
+.. she .. she couldn't get it .. now we are
+
+79
+00:07:45,030 --> 00:07:48,050
+talking .. look the pronoun .. this is called ..
+
+80
+00:07:48,050 --> 00:07:50,910
+it refers to the noun .. this noun .. this is
+
+81
+00:07:50,910 --> 00:07:57,110
+called the antecedentانتسيدانت ماذا يعني هذا؟ هل
+
+82
+00:07:57,110 --> 00:08:03,850
+يعني السيارة أو صديقي؟ لأنهم .. هم ماذا؟ أصدقائي
+
+83
+00:08:03,850 --> 00:08:11,070
+.. إذا .. إذا كنت ترغب في كتابة كلمة بدل الاسم،
+
+84
+00:08:11,070 --> 00:08:18,050
+ماذا يجب أن تكتب؟ لأن أصدقائي .. لأن
+
+85
+00:08:18,050 --> 00:08:22,820
+أصدقائي يسألونOkay to borrow my car because
+
+86
+00:08:22,820 --> 00:08:27,480
+there's was. So there refers to my friends. Now
+
+87
+00:08:27,480 --> 00:08:30,340
+there's .. who can use this word in a sentence?
+
+88
+00:08:30,920 --> 00:08:31,180
+Look.
+
+89
+00:08:35,100 --> 00:08:38,000
+Who can use it with apostrophe in a sentence?
+
+90
+00:08:38,180 --> 00:08:42,300
+Yeah. Very good. There is a laptop on the table.
+
+91
+00:08:44,060 --> 00:08:47,180
+Now let's start talking about pronouns.
+
+92
+00:09:11,570 --> 00:09:17,230
+personal pronouns they are divided into what
+
+93
+00:09:17,230 --> 00:09:22,730
+subject pronouns object pronouns possessive
+
+94
+00:09:22,730 --> 00:09:28,030
+adjectives pronouns now let's start by the first
+
+95
+00:09:28,030 --> 00:09:34,930
+groupI live in Gaza where is the subject I good
+
+96
+00:09:34,930 --> 00:09:39,610
+use you in a similar sentence yeah you are a
+
+97
+00:09:39,610 --> 00:09:43,310
+teacher where is the subject you you good use she
+
+98
+00:09:43,310 --> 00:09:47,990
+in a sentence yeah she's a good girl thank you
+
+99
+00:09:47,990 --> 00:09:53,710
+where is the subject she he yeah he's a student
+
+100
+00:09:53,710 --> 00:09:57,750
+good where is the subject he use it in a sentence
+
+101
+00:10:00,630 --> 00:10:04,930
+it is a nice cat where is the subject okay thank
+
+102
+00:10:04,930 --> 00:10:09,930
+you now so these they are called what subject
+
+103
+00:10:09,930 --> 00:10:14,170
+pronouns because they are used as the subject of
+
+104
+00:10:14,170 --> 00:10:18,380
+the sentence or they refer to the subjectthey
+
+105
+00:10:18,380 --> 00:10:23,840
+refer to the subject فاطمة is a good student she
+
+106
+00:10:23,840 --> 00:10:29,220
+is my sister she is my sister she refers to what
+
+107
+00:10:29,220 --> 00:10:34,100
+to فاطمة so they can be used as a subject or they
+
+108
+00:10:34,100 --> 00:10:37,140
+can refer to the subject now what about the other
+
+109
+00:10:37,140 --> 00:10:42,140
+group me my
+
+110
+00:10:42,140 --> 00:10:45,990
+little sister received meOkay my little sister
+
+111
+00:10:45,990 --> 00:10:52,590
+respects me very good now she respects
+
+112
+00:10:52,590 --> 00:11:01,610
+me good this is the object thank you yeah I'll
+
+113
+00:11:01,610 --> 00:11:07,190
+give you I'll give you good that's right thank you
+
+114
+00:11:07,190 --> 00:11:09,410
+yeah again
+
+115
+00:11:13,090 --> 00:11:18,330
+Okay this is a good example okay exams make me
+
+116
+00:11:18,330 --> 00:11:22,970
+okay make me nervous good thank you now you what
+
+117
+00:11:22,970 --> 00:11:25,450
+about you can you use it as a sentence as an
+
+118
+00:11:25,450 --> 00:11:28,950
+object makes
+
+119
+00:11:28,950 --> 00:11:35,770
+me she said me we want you a present you are right
+
+120
+00:11:35,770 --> 00:11:40,390
+that's right her all
+
+121
+00:11:40,390 --> 00:11:44,060
+the audience looking at herat her now looking at
+
+122
+00:11:44,060 --> 00:11:49,540
+her look at her here is preceded by what at okay
+
+123
+00:11:49,540 --> 00:11:53,840
+so it is the we call it object of the preposition
+
+124
+00:11:53,840 --> 00:11:58,260
+we have two types of object this is an object okay
+
+125
+00:11:58,260 --> 00:12:03,280
+but if i say for me for example it will be the
+
+126
+00:12:03,280 --> 00:12:08,340
+object of the prepositionOkay now if you say I saw
+
+127
+00:12:08,340 --> 00:12:16,400
+her yesterday I saw her yesterday I saw you I saw
+
+128
+00:12:16,400 --> 00:12:23,680
+her I saw him okay yesterday where
+
+129
+00:12:23,680 --> 00:12:29,800
+is the object okay thank you now what about the
+
+130
+00:12:29,800 --> 00:12:31,580
+other group possessive pronouns
+
+131
+00:12:35,420 --> 00:12:39,600
+yes please again
+
+132
+00:12:39,600 --> 00:12:49,760
+thank you this book is
+
+133
+00:12:49,760 --> 00:12:56,000
+mine very good this book is mine look
+
+134
+00:12:58,880 --> 00:13:02,640
+can I or shall I use a noun or a word after this
+
+135
+00:13:02,640 --> 00:13:07,760
+pronoun؟ no I cannot use okay is mine yeah use
+
+136
+00:13:07,760 --> 00:13:11,340
+yours in a sentence yeah this wallet is yours this
+
+137
+00:13:11,340 --> 00:13:14,020
+wallet is yours good where is it give it to me
+
+138
+00:13:14,020 --> 00:13:20,180
+okay this wallet is yours thank you the other one
+
+139
+00:13:20,180 --> 00:13:31,720
+hairs yes pleaseuse okay now we want this one this
+
+140
+00:13:31,720 --> 00:13:39,060
+laptop is hers okay okay فاطما is my sister this
+
+141
+00:13:39,060 --> 00:13:43,660
+laptop is hers okay is hers it is for her is his
+
+142
+00:13:43,660 --> 00:13:48,080
+and so on and the last group again possessive
+
+143
+00:13:48,080 --> 00:13:51,520
+adjective now so we have possessive pronouns and
+
+144
+00:13:51,520 --> 00:13:56,890
+possessive adjectives okay yes pleasethis is my
+
+145
+00:13:56,890 --> 00:14:05,870
+book look good this is this is my book now what's
+
+146
+00:14:05,870 --> 00:14:08,590
+the difference between the first group and the
+
+147
+00:14:08,590 --> 00:14:13,110
+second group look is mine and my book who can give
+
+148
+00:14:13,110 --> 00:14:19,050
+me the difference yeah this is my book followed by
+
+149
+00:14:19,050 --> 00:14:24,860
+a nouncannot be followed by a noun so a positive
+
+150
+00:14:24,860 --> 00:14:28,800
+adjective should always be followed by what a noun
+
+151
+00:14:28,800 --> 00:14:34,320
+adjectives like that can i say this is a red this
+
+152
+00:14:34,320 --> 00:14:38,200
+is a beautiful for example no this is a beautiful
+
+153
+00:14:38,200 --> 00:14:45,230
+flower okay it is a coldhas no meaning right it is
+
+154
+00:14:45,230 --> 00:14:51,130
+a cold weather it is a nice story and so on it is
+
+155
+00:14:51,130 --> 00:14:56,610
+an easy easy what easy exam and so on you know so
+
+156
+00:14:56,610 --> 00:15:00,050
+again adjectives should be followed by nouns and
+
+157
+00:15:00,050 --> 00:15:04,250
+these also pronouns should be followed by nouns so
+
+158
+00:15:04,250 --> 00:15:08,390
+we say this is my book your book his book her book
+
+159
+00:15:08,390 --> 00:15:15,080
+and so on now this group we used whatthe pronouns
+
+160
+00:15:15,080 --> 00:15:18,780
+are all in the singular form let's come to the
+
+161
+00:15:18,780 --> 00:15:24,020
+plural okay the same thing instead of saying I
+
+162
+00:15:24,020 --> 00:15:30,560
+yeah we are studying English grammar now very good
+
+163
+00:15:30,560 --> 00:15:36,080
+we are studying English grammar you you should
+
+164
+00:15:36,080 --> 00:15:41,820
+take care of yourself thank you I'll do good yeah
+
+165
+00:15:42,770 --> 00:15:45,610
+they are .. they are playing football they are
+
+166
+00:15:45,610 --> 00:15:49,630
+playing football good thank you very much okay now
+
+167
+00:15:49,630 --> 00:15:57,990
+us us yeah okay
+
+168
+00:15:57,990 --> 00:16:05,350
+the teacher told us a story about okay now you
+
+169
+00:16:05,350 --> 00:16:08,710
+they
+
+170
+00:16:08,710 --> 00:16:20,260
+visited usthey visited us we are visiting I will
+
+171
+00:16:20,260 --> 00:16:29,600
+visit you tomorrow good now them I'll
+
+172
+00:16:29,600 --> 00:16:34,960
+give them some advice thank you now this car is
+
+173
+00:16:35,740 --> 00:16:42,840
+ours okay this villa is yours okay this laptop is
+
+174
+00:16:42,840 --> 00:16:48,820
+theirs okay and we say this is our house this is
+
+175
+00:16:48,820 --> 00:16:55,320
+our university this is your book and this is their
+
+176
+00:16:55,320 --> 00:16:59,240
+their house their book and so on
+
+177
+00:17:05,690 --> 00:17:09,930
+So what do we come out from these pronouns؟ Yes,
+
+178
+00:17:10,010 --> 00:17:12,870
+can you talk, can you say something about these
+
+179
+00:17:12,870 --> 00:17:17,830
+pronouns؟ personal pronouns we have four groups
+
+180
+00:17:17,830 --> 00:17:21,590
+for it subject, object, possessive and possessive
+
+181
+00:17:21,590 --> 00:17:24,970
+pronoun and possessive adjectives we use it even
+
+182
+00:17:24,970 --> 00:17:29,750
+singular or plural good thank you now possessive
+
+183
+00:17:29,750 --> 00:17:32,030
+pronouns and adjectives what's the main difference
+
+184
+00:17:32,030 --> 00:17:35,570
+between them?what's the main difference يا خديجة؟
+
+185
+00:17:35,570 --> 00:17:40,430
+should be
+
+186
+00:17:40,430 --> 00:17:46,510
+followed by a noun okay
+
+187
+00:17:46,510 --> 00:17:53,330
+good now look at this sentence I read a book it
+
+188
+00:17:53,330 --> 00:17:59,700
+was good I read a book it was goodit refers to
+
+189
+00:17:59,700 --> 00:18:06,760
+book what book is called antecedent book is called
+
+190
+00:18:06,760 --> 00:18:13,520
+antecedent now what type of pronoun is it singular
+
+191
+00:18:13,520 --> 00:18:19,780
+subject okay it refers to the subject look I read
+
+192
+00:18:19,780 --> 00:18:27,740
+some booksthey were good now a pronoun is used
+
+193
+00:18:27,740 --> 00:18:32,340
+instead of what? instead of repeating I read some
+
+194
+00:18:32,340 --> 00:18:35,440
+books, the books were .. so I don't repeat,
+
+195
+00:18:35,620 --> 00:18:38,740
+repetition should be avoided in writing you know
+
+196
+00:18:40,210 --> 00:18:45,390
+أنا أستخدم نمو بدل نمو، يمكن أن يكون عملي، يمكن أن
+
+197
+00:18:45,390 --> 00:18:46,250
+يكون عملي، يمكن أن يكون عملي، يمكن أن يكون عملي،
+
+198
+00:18:46,250 --> 00:18:48,490
+يمكن أن يكون عملي، يمكن أن يكون عملي، يمكن أن تكون
+
+199
+00:18:48,490 --> 00:18:49,570
+عملي، يمكن أن تكون عملي، يمكن أن تكون عملي، يمكن
+
+200
+00:18:49,570 --> 00:18:50,070
+أن تكون عملي، يمكن أن تكون عملي، يمكن أن تكون
+
+201
+00:18:50,070 --> 00:18:50,090
+عملي، يمكن أن تكون عملي، يمكن أن تكون عملي، يمكن
+
+202
+00:18:50,090 --> 00:18:50,090
+أن تكون عملي، يمكن أن تكون عملي، يمكن أن تكون
+
+203
+00:18:50,090 --> 00:18:50,570
+عملي، يمكن أن تكون عملي، يمكن أن تكون عملي، يمكن
+
+204
+00:18:50,570 --> 00:18:55,570
+أن تكون عملي، يمكن أن تكون عملي، يمكن أن تكون
+
+205
+00:18:55,570 --> 00:19:03,830
+عملي، يمكن أن تكون عملي، يمكن
+
+206
+00:19:05,250 --> 00:19:09,770
+plural to refer to the plural okay thank you now
+
+207
+00:19:09,770 --> 00:19:16,210
+book and books yeah book and books they are called
+
+208
+00:19:16,210 --> 00:19:22,650
+antecedents antecedents this is Fatima she's my
+
+209
+00:19:22,650 --> 00:19:30,890
+sister Fatima is what antecedent now read this
+
+210
+00:19:30,890 --> 00:19:31,990
+point please
+
+211
+00:19:38,830 --> 00:19:44,410
+thank you singular to singular plural to plural I
+
+212
+00:19:44,410 --> 00:19:49,770
+think this is clear right no questions good now
+
+213
+00:19:49,770 --> 00:19:57,230
+look I like tea now when I say Fatima is my sister
+
+214
+00:19:57,230 --> 00:20:06,920
+Huda is my sisterI stated the subject clearly okay
+
+215
+00:20:06,920 --> 00:20:11,420
+when I say huda is my sister she's living there
+
+216
+00:20:11,420 --> 00:20:18,000
+she refers to huda so I mentioned her name okay so
+
+217
+00:20:18,000 --> 00:20:22,820
+you can understand what does she refer to but when
+
+218
+00:20:22,820 --> 00:20:29,740
+I begin with the pronoun I like tea you like teaI
+
+219
+00:20:29,740 --> 00:20:36,540
+like tea you like tea now is the antecedent now I
+
+220
+00:20:36,540 --> 00:20:41,960
+refers to what the speaker very good thank you
+
+221
+00:20:41,960 --> 00:20:49,750
+very much and you refers to whatthe person you are
+
+222
+00:20:49,750 --> 00:20:54,050
+talking to the person you are talking to now in
+
+223
+00:20:54,050 --> 00:20:58,690
+the previous sentences when i say this is a book
+
+224
+00:20:58,690 --> 00:21:03,630
+okay it is easy for example it refers to the book
+
+225
+00:21:03,630 --> 00:21:08,690
+it is refers to the antecedent the antecedent is
+
+226
+00:21:08,690 --> 00:21:12,570
+what clear yes is mentioned clearly you can
+
+227
+00:21:12,570 --> 00:21:17,670
+understand itمن السلسلة يمكنك أن تقرأها في السلسلة
+
+228
+00:21:17,670 --> 00:21:25,030
+ولكن الآن I يتعلق إلى أين هو الاتصال؟ ليس مذكرة
+
+229
+00:21:25,030 --> 00:21:30,870
+ولكن يمكن أن تفهمها أنت تعرف أن أنا أتحدث عن نفسي،
+
+230
+00:21:30,870 --> 00:21:34,290
+أنت تتحدث عن بعض الناس، أنا أتحدث أيضًا، لذلك
+
+231
+00:21:34,290 --> 00:21:41,990
+الاتصال هنا يمكن أن تفهمه، ليس مذكرة بشكل واضح،
+
+232
+00:21:41,990 --> 00:21:51,250
+لذلكالتحدث، هل تحب الطعام إلى الواحد؟ أنا أتكلم
+
+233
+00:21:51,250 --> 00:21:52,870
+أيضًا. حسنًا.
+
+234
+00:21:55,990 --> 00:22:01,050
+الآن، انظر إلى الفعل. نعم، قرر، أرجوك قرر الفعل.
+
+235
+00:22:01,810 --> 00:22:05,890
+جهاد لديه سيارة، يحرك إلى العمل. حسنًا، يحرك إلى
+
+236
+00:22:05,890 --> 00:22:11,020
+العمل.Now جهاد has a car. He drives to work. Where
+
+237
+00:22:11,020 --> 00:22:14,400
+is the subject in this sentence? جهاد. Where is
+
+238
+00:22:14,400 --> 00:22:19,360
+the object? A car. Now he drives to work. What
+
+239
+00:22:19,360 --> 00:22:23,570
+does he refer? Where is the antecedent?جهاد Now
+
+240
+00:22:23,570 --> 00:22:28,450
+this is what؟ a subject، this is a subject okay؟
+
+241
+00:22:28,450 --> 00:22:32,210
+Now in the other sentence, this is a subject, so
+
+242
+00:22:32,210 --> 00:22:36,850
+this pronoun, a subject pronoun is used as a
+
+243
+00:22:36,850 --> 00:22:41,730
+subject, right؟ it also refers to a subject Can
+
+244
+00:22:41,730 --> 00:22:45,250
+you give me an example like that? Give me an
+
+245
+00:22:45,250 --> 00:22:45,650
+example
+
+246
+00:22:50,210 --> 00:22:53,770
+marwa is absent she has a wedding very good thank
+
+247
+00:22:53,770 --> 00:22:59,430
+you marwa is she has and also she refers to marwa
+
+248
+00:22:59,430 --> 00:23:04,510
+that's nice now look at the other sentence jihad
+
+249
+00:23:04,510 --> 00:23:08,970
+works in my office where is the object
+
+250
+00:23:13,470 --> 00:23:19,410
+Jihad works in my office I know him I know him him
+
+251
+00:23:19,410 --> 00:23:24,250
+refers to what to jihad okay him refers to this is
+
+252
+00:23:24,250 --> 00:23:28,950
+the object of what of the verb this is the object
+
+253
+00:23:28,950 --> 00:23:34,350
+of the verb I know him okay but in this sentence I
+
+254
+00:23:34,350 --> 00:23:40,280
+talk to him every dayI talked to him him is an
+
+255
+00:23:40,280 --> 00:23:43,960
+object pronoun in this sentence after the
+
+256
+00:23:43,960 --> 00:23:47,300
+preposition it is called what object of the
+
+257
+00:23:47,300 --> 00:23:51,660
+preposition so we have two types of objects object
+
+258
+00:23:51,660 --> 00:23:56,260
+of the verb and object of the preposition the
+
+259
+00:23:56,260 --> 00:23:59,440
+object of the verb is mentioned as you see after
+
+260
+00:23:59,440 --> 00:24:02,320
+the verb and the object of the preposition is
+
+261
+00:24:02,320 --> 00:24:04,920
+mentioned after the preposition
+
+262
+00:24:08,090 --> 00:24:11,290
+look at this sentence would you read please read
+
+263
+00:24:11,290 --> 00:24:17,070
+the sentence okay that book is hairs
+
+264
+00:24:17,070 --> 00:24:22,510
+okay good go on okay
+
+265
+00:24:22,510 --> 00:24:27,650
+yours is over there thank you now hairs and yours
+
+266
+00:24:27,650 --> 00:24:30,950
+we called them what or they are called what
+
+267
+00:24:31,980 --> 00:24:35,900
+possessive pronouns thank you yeah are not
+
+268
+00:24:35,900 --> 00:24:39,040
+followed by what a noun they should not be
+
+269
+00:24:39,040 --> 00:24:41,520
+followed by a noun if you look at this sentence
+
+270
+00:24:41,520 --> 00:24:45,340
+shall i use a noun after this one no shall i use a
+
+271
+00:24:45,340 --> 00:24:49,420
+noun here no it is not used so again these
+
+272
+00:24:49,420 --> 00:24:52,760
+pronouns are not followed immediately by a noun
+
+273
+00:24:52,760 --> 00:24:59,500
+they stand alone don't say that book is hers okay
+
+274
+00:24:59,500 --> 00:25:05,180
+don't saythis is hers you know that book is yours
+
+275
+00:25:05,180 --> 00:25:09,800
+is over there hairs should be written like that
+
+276
+00:25:09,800 --> 00:25:15,240
+okay without apostrophe very goodsome students are
+
+277
+00:25:15,240 --> 00:25:18,860
+fond of writing the apostrophe just they write
+
+278
+00:25:18,860 --> 00:25:21,840
+apostrophe here and apostrophe there you know
+
+279
+00:25:21,840 --> 00:25:25,380
+apostrophe is good when needed if you need it
+
+280
+00:25:25,380 --> 00:25:29,580
+write it if it is not needed you should avoid it
+
+281
+00:25:29,580 --> 00:25:33,360
+okay so in this case it is not needed in these
+
+282
+00:25:33,360 --> 00:25:37,040
+pronouns we say hers without apostrophe and yours
+
+283
+00:25:37,040 --> 00:25:42,960
+without apostrophe now
+
+284
+00:25:44,480 --> 00:25:50,100
+look hair book, your book what type of pronouns
+
+285
+00:25:50,100 --> 00:25:56,540
+are these hair and your possessive adjectives okay
+
+286
+00:25:56,540 --> 00:26:01,920
+can they stand alone no they are like the
+
+287
+00:26:01,920 --> 00:26:05,480
+adjectives they cannot stand alone they should be
+
+288
+00:26:05,480 --> 00:26:08,220
+followed by what by nouns good
+
+289
+00:26:12,560 --> 00:26:19,740
+now read the sentence please yeah
+
+290
+00:26:19,740 --> 00:26:24,480
+a bird uses its wings to fly its wings what type
+
+291
+00:26:24,480 --> 00:26:30,140
+of pronoun is its okay now shall we use an
+
+292
+00:26:30,140 --> 00:26:34,200
+apostrophe here no it is not accepted to write it
+
+293
+00:26:34,200 --> 00:26:39,260
+with apostrophe this isincorrect okay with
+
+294
+00:26:39,260 --> 00:26:43,160
+apostrophe it is not accepted now look at this
+
+295
+00:26:43,160 --> 00:26:50,460
+sentence it it's been in business since 1933 it's
+
+296
+00:26:50,460 --> 00:26:58,180
+been it has been it has been so again it has an
+
+297
+00:26:58,180 --> 00:27:03,640
+apostrophe or you knowSo again as we said look
+
+298
+00:27:03,640 --> 00:27:07,840
+it's called today it's called today the apostrophe
+
+299
+00:27:07,840 --> 00:27:10,660
+is used with it in two cases
+
+300
+00:27:13,100 --> 00:27:19,280
+in abbreviations right now is is abbreviated there
+
+301
+00:27:19,280 --> 00:27:24,420
+instead of writing it is we say it's to show that
+
+302
+00:27:24,420 --> 00:27:28,180
+something is omitted we don't write a full is a
+
+303
+00:27:28,180 --> 00:27:32,600
+complete is so instead of writing it is okay we
+
+304
+00:27:32,600 --> 00:27:36,420
+omit a part of the verb is and write apostrophe to
+
+305
+00:27:36,420 --> 00:27:40,660
+show that there is omission something is deleted
+
+306
+00:27:41,650 --> 00:27:48,370
+والآخر بدل من كتابة لديه .. نكتب الـ apostrophe،
+
+307
+00:27:48,370 --> 00:27:52,950
+هذا صحيح وكما
+
+308
+00:27:52,950 --> 00:27:56,350
+تعلمين، هذه منطقة خطأ، حتى المتحدثين الوطنيين
+
+309
+00:27:56,350 --> 00:27:59,490
+يفعلوا بعض الخطوات في هذه المنطقة، انظروا إلى هذه
+
+310
+00:27:59,490 --> 00:28:06,390
+التعليقات، السلسلة الأولى اكتشف الاسم الخاص بهم
+
+311
+00:28:06,390 --> 00:28:10,210
+ومقابلاتهم، من يريد أن يأتي إلى البرج؟
+
+312
+00:28:15,480 --> 00:28:28,140
+come please okay
+
+313
+00:28:28,140 --> 00:28:31,460
+they
+
+314
+00:28:31,460 --> 00:28:36,320
+okay now where is the pronoun and where is the
+
+315
+00:28:36,320 --> 00:28:42,900
+antecedentno no no just underline .. just write ..
+
+316
+00:28:42,900 --> 00:28:46,840
+draw a circle around the antecedent draw a circle
+
+317
+00:28:46,840 --> 00:28:50,040
+and underline the pronoun okay this is the
+
+318
+00:28:50,040 --> 00:28:54,040
+antecedent good and the pronouns thank you next
+
+319
+00:28:54,040 --> 00:28:59,420
+one come ياسمين the teacher graded a student's
+
+320
+00:28:59,420 --> 00:29:02,160
+paper last night she returned them during class
+
+321
+00:29:02,160 --> 00:29:07,080
+today the teacher's antecedent
+
+322
+00:29:09,680 --> 00:29:17,480
+شكرا، الرقم أربعة، نعم، أتركي أرجوك
+
+323
+00:29:17,480 --> 00:29:23,140
+ناسي أخدت أفل معها للعمل، و أكلت أكتر من أكتر من
+
+324
+00:29:23,140 --> 00:29:23,340
+أكتر من أكتر من أكتر من أكتر من أكتر من أكتر من
+
+325
+00:29:23,340 --> 00:29:24,380
+أكتر من أكتر من أكتر من أكتر من أكتر من أكتر من
+
+326
+00:29:24,380 --> 00:29:26,860
+أكتر من أكتر من أكتر من أكتر من أكتر من أكتر من
+
+327
+00:29:26,860 --> 00:29:26,960
+أكتر من أكتر من أكتر من أكتر من أكتر من أكتر من
+
+328
+00:29:26,960 --> 00:29:27,260
+أكتر من أكتر من أكتر من أكتر من أكتر من أكتر من
+
+329
+00:29:27,260 --> 00:29:32,000
+أكتر من أكتر من أكتر من أكتر من
+
+330
+00:29:32,000 --> 00:29:35,700
+أكjust a minute look at the first sentence Nancy
+
+331
+00:29:35,700 --> 00:29:38,380
+took an apple with her look at the first sentence
+
+332
+00:29:38,380 --> 00:29:42,560
+okay this is the pronoun right it refers to Nancy
+
+333
+00:29:42,560 --> 00:29:50,620
+and she is it a pronoun or antecedent a pronoun so
+
+334
+00:29:50,620 --> 00:29:55,020
+underline it we circle the antecedent thank you
+
+335
+00:29:55,020 --> 00:29:58,880
+just a minute just a minute she did not finish
+
+336
+00:29:58,880 --> 00:30:00,460
+okay
+
+337
+00:30:02,420 --> 00:30:07,520
+yeah she ate it yeah it refers to apple good so
+
+338
+00:30:07,520 --> 00:30:11,640
+underline it and circle okay yes what did you want
+
+339
+00:30:11,640 --> 00:30:16,000
+to say she
+
+340
+00:30:16,000 --> 00:30:20,420
+returned
+
+341
+00:30:20,420 --> 00:30:24,140
+them the teacher regretted the students papers she
+
+342
+00:30:24,140 --> 00:30:27,440
+you are right thank you okay them refers to
+
+343
+00:30:27,440 --> 00:30:31,240
+students papers this is another one okay good
+
+344
+00:30:33,920 --> 00:30:43,840
+thank you next one yes come please
+
+345
+00:30:43,840 --> 00:30:50,520
+thank
+
+346
+00:30:50,520 --> 00:30:53,920
+you
+
+347
+00:30:53,920 --> 00:30:59,140
+number six come
+
+348
+00:30:59,140 --> 00:30:59,540
+please
+
+349
+00:31:05,610 --> 00:31:09,070
+الطيبة يوري اسمها
+
+350
+00:31:09,070 --> 00:31:16,450
+my bully alice هي مستقلة جدا، لم تتعامل مع يوري،
+
+351
+00:31:16,450 --> 00:31:22,510
+والحيوانات تتعامل معه بمجرد ذلك، يحبون أن تقابله
+
+352
+00:31:22,510 --> 00:31:29,350
+أولا، الطيبة يوري اسمها ..
+
+353
+00:31:29,960 --> 00:31:33,340
+yuri's cat this is the antecedent okay good where
+
+354
+00:31:33,340 --> 00:31:37,860
+is the pronoun which refers to it she now you look
+
+355
+00:31:37,860 --> 00:31:41,860
+with the cat if the gender if the sex of the
+
+356
+00:31:41,860 --> 00:31:45,260
+animal male or female is known and is given a name
+
+357
+00:31:45,260 --> 00:31:49,940
+they say he or she okay this is something normal
+
+358
+00:31:49,940 --> 00:31:56,020
+go on she never offends yuri she also for yuri's
+
+359
+00:31:56,020 --> 00:31:58,600
+cat yes
+
+360
+00:32:00,710 --> 00:32:04,310
+his dogs refers
+
+361
+00:32:04,310 --> 00:32:09,090
+to يوري's cats
+
+362
+00:32:09,090 --> 00:32:19,050
+no to يوري not to cat his dogs يوري's dogs on the
+
+363
+00:32:19,050 --> 00:32:28,750
+other hand obey him to يوري they like to please
+
+364
+00:32:28,750 --> 00:32:37,120
+him they dogsand him his dogs him yuri him yuri
+
+365
+00:32:37,120 --> 00:32:48,540
+good thank you very much check
+
+366
+00:32:48,540 --> 00:32:52,680
+your answers make sure that you got the right
+
+367
+00:32:52,680 --> 00:32:55,080
+answers you have the right answers
+
+368
+00:33:20,920 --> 00:33:30,460
+let's move to the other exercise read
+
+369
+00:33:30,460 --> 00:33:36,760
+what does he want he is
+
+370
+00:33:36,760 --> 00:33:39,500
+giving us two options
+
+371
+00:33:42,070 --> 00:33:46,150
+not a number of native English speakers commonly
+
+372
+00:33:46,150 --> 00:33:49,490
+use subject pronouns after and even when the
+
+373
+00:33:49,490 --> 00:33:52,450
+grammatically correct choice is an object pronoun
+
+374
+00:33:52,450 --> 00:33:55,650
+thank you now what does that mean what do we
+
+375
+00:33:55,650 --> 00:34:00,270
+understand okay what do we understand in the first
+
+376
+00:34:00,270 --> 00:34:05,190
+sentence a number he saysa number of native
+
+377
+00:34:05,190 --> 00:34:09,170
+speakers commonly use as subject pronouns after
+
+378
+00:34:09,170 --> 00:34:13,550
+and even when the grammatically correct choice is
+
+379
+00:34:13,550 --> 00:34:17,470
+an object to pronounce what does that mean؟ like
+
+380
+00:34:17,470 --> 00:34:20,570
+in the first sentence the correct answer is an
+
+381
+00:34:20,570 --> 00:34:24,190
+object to pronoun me but they may use and I that's
+
+382
+00:34:24,190 --> 00:34:28,190
+right yeah they use I but we should say what؟ memy
+
+383
+00:34:28,190 --> 00:34:34,230
+parents always read bedtime stories to my sister
+
+384
+00:34:34,230 --> 00:34:41,550
+and .. and I or and me and why؟ why me not I؟ okay
+
+385
+00:34:41,550 --> 00:34:45,050
+it is object of the proposition that's right but
+
+386
+00:34:45,050 --> 00:34:50,590
+native speakers usually use what؟ okay good so
+
+387
+00:34:50,590 --> 00:34:54,990
+number two .. who wants to make number two?
+
+388
+00:34:57,860 --> 00:35:02,500
+يه؟ who wants to write to answer number two؟ يه
+
+389
+00:35:02,500 --> 00:35:09,080
+كم؟ كم يا سمين؟
+
+390
+00:35:09,080 --> 00:35:16,380
+do it just between you and me I think Mr. Lucas is
+
+391
+00:35:16,380 --> 00:35:19,860
+going to lose هجرة good thank you between you and
+
+392
+00:35:19,860 --> 00:35:21,980
+me يه كم؟
+
+393
+00:35:31,650 --> 00:35:42,030
+to him good thank you I need to tell you and thank
+
+394
+00:35:42,030 --> 00:35:51,110
+you good yes please
+
+395
+00:35:51,110 --> 00:35:51,630
+come
+
+396
+00:35:57,870 --> 00:36:00,650
+السيد ميزيكي يحتاج إلى أن يعرف الطريقة التي
+
+397
+00:36:00,650 --> 00:36:08,850
+سأخبرها الشيخ شانج و هيرد الطريقة انا
+
+398
+00:36:08,850 --> 00:36:18,890
+قاعدة طبعا حسنا ماذا فعلت؟ انا سأخبر شانج و هيرد
+
+399
+00:36:18,890 --> 00:36:20,990
+حسنا شكرا و أخيرا
+
+400
+00:36:33,840 --> 00:36:44,760
+السيدة؟ شكرا اتفقنا
+
+401
+00:36:44,760 --> 00:36:48,560
+بإجابتك مرة أخرى، اتفقنا بإجابتك مرة أخرى،
+
+402
+00:37:12,220 --> 00:37:16,840
+Now look at the new exercise complete the
+
+403
+00:37:16,840 --> 00:37:21,340
+sentences in each situation with pronoun for the
+
+404
+00:37:21,340 --> 00:37:24,640
+word in italic situation for example situation one
+
+405
+00:37:24,640 --> 00:37:29,380
+there is Sarah I need to go to talk to her
+
+406
+00:37:35,330 --> 00:37:40,110
+I need to go talk to her she and I good she and I
+
+407
+00:37:40,110 --> 00:37:43,310
+thank you number three quickly this is an easy
+
+408
+00:37:43,310 --> 00:37:46,990
+exercise yeah come please I went to elementary
+
+409
+00:37:46,990 --> 00:37:54,150
+school
+
+410
+00:37:54,150 --> 00:37:59,670
+with her brother and I and her and her yes
+
+411
+00:37:59,670 --> 00:38:02,590
+together it means that we went together to her
+
+412
+00:38:02,590 --> 00:38:06,430
+brother and herI went with her okay I went with
+
+413
+00:38:06,430 --> 00:38:12,810
+her brother and her okay yeah come please next one
+
+414
+00:38:12,810 --> 00:38:23,050
+number four good
+
+415
+00:38:23,050 --> 00:38:26,850
+thank you تفضلي
+
+416
+00:38:32,510 --> 00:38:40,390
+هي تتزوج في الشهر القادم قبل
+
+417
+00:38:40,390 --> 00:38:42,190
+انتشار قبل انتشار قبل انتشار قبل انتشار قبل انتشار
+
+418
+00:38:42,190 --> 00:38:43,030
+قبل انتشار قبل انتشار قبل انتشار قبل انتشار قبل
+
+419
+00:38:43,030 --> 00:38:44,270
+انتشار قبل انتشار قبل انتشار قبل انتشار قبل انتشار
+
+420
+00:38:44,270 --> 00:38:47,290
+قبل انتشار قبل انتشار قبل انتشار قبل انتشار قبل
+
+421
+00:38:47,290 --> 00:38:48,750
+انتشار قبل انتشار قبل انتشار قبل انتشار قبل انتشار
+
+422
+00:38:48,750 --> 00:38:50,850
+قبل انتشار قبل انتشار قبل انتشار قبل انتشار قبل
+
+423
+00:38:50,850 --> 00:38:51,270
+انتشار قبل انتشار قبل انتشار قبل انتشار قبل انتشار
+
+424
+00:38:51,270 --> 00:38:56,150
+قبل انتشار قبل انتشار قبل انتشار ق
+
+425
+00:39:04,390 --> 00:39:10,390
+come again please being with her is a lot of fun
+
+426
+00:39:10,390 --> 00:39:17,510
+we laugh a lot thank you thank you yeah come
+
+427
+00:39:17,510 --> 00:39:27,790
+please she
+
+428
+00:39:27,790 --> 00:39:32,010
+has a good time with her friends very good
+
+429
+00:39:35,690 --> 00:39:40,170
+she always has a good time with her friends
+
+430
+00:39:40,170 --> 00:39:45,590
+situation two I'm not feeling well I think I'd
+
+431
+00:39:45,590 --> 00:39:54,850
+better stay at home today okay my friends and come
+
+432
+00:39:54,850 --> 00:40:01,190
+yes come let she come my friends and I
+
+433
+00:40:05,500 --> 00:40:11,840
+our local bank today clean the other words clean
+
+434
+00:40:11,840 --> 00:40:15,820
+them please okay can you do the other one number
+
+435
+00:40:15,820 --> 00:40:27,940
+nine read it and do it try it try number nine okay
+
+436
+00:40:27,940 --> 00:40:33,970
+thank you goodmy friends and me thank you number
+
+437
+00:40:33,970 --> 00:40:46,410
+ten فضلي come my friend
+
+438
+00:40:46,410 --> 00:40:51,130
+will have to go without me thank you do the other
+
+439
+00:40:51,130 --> 00:40:56,500
+one eleven read it I'd better I'd better callmy
+
+440
+00:40:56,500 --> 00:41:01,680
+friend's son thank you good and finally the last
+
+441
+00:41:01,680 --> 00:41:08,120
+one for today noor you
+
+442
+00:41:08,120 --> 00:41:12,700
+did enough today thank you very much you could I
+
+443
+00:41:12,700 --> 00:41:20,520
+use your cell phone I don't have it I don't
+
+444
+00:41:20,520 --> 00:41:25,510
+havemine with me okay I don't have my phone or my
+
+445
+00:41:25,510 --> 00:41:37,470
+mine I don't have mine with me thank you thank
+
+446
+00:41:37,470 --> 00:41:38,110
+you very much
+
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/RMnY5pPpBHo_postprocess.srt b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/RMnY5pPpBHo_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..1ac6b2b22c43f682d69e2540a234abf78b831e39
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/RMnY5pPpBHo_postprocess.srt
@@ -0,0 +1,2004 @@
+1
+00:00:20,590 --> 00:00:23,850
+Okay, now let's start. Good morning to you all.
+
+2
+00:00:24,930 --> 00:00:30,350
+How are you? Okay, feeling well today? Good. How
+
+3
+00:00:30,350 --> 00:00:34,750
+is the weather today? One speaker, please. One
+
+4
+00:00:34,750 --> 00:00:39,110
+speaker, yeah. It's cold, good. The weather is
+
+5
+00:00:39,110 --> 00:00:45,390
+cold. You know, because .. Yes, Yasmeen, you want
+
+6
+00:00:45,390 --> 00:00:51,360
+to say something?Okay thank you So because the
+
+7
+00:00:51,360 --> 00:00:56,680
+weather is cold Nada is going to buy a new coat
+
+8
+00:00:56,680 --> 00:01:06,940
+Nada is going to buy a new coat She is going to
+
+9
+00:01:06,940 --> 00:01:15,900
+buy a new coat Who can express the same meaning in
+
+10
+00:01:15,900 --> 00:01:22,410
+other words?yes مروة she will buy a new coat very
+
+11
+00:01:22,410 --> 00:01:30,390
+good she will buy a new coat she will buy a new
+
+12
+00:01:30,390 --> 00:01:34,470
+coat she's going to buy she will buy a new coat
+
+13
+00:01:34,470 --> 00:01:39,410
+now which tense is used here which tense yeah it
+
+14
+00:01:39,410 --> 00:01:42,190
+is the simple future very good it is the simple
+
+15
+00:01:42,190 --> 00:01:47,350
+future now we talk and what do we want to say now
+
+16
+00:01:51,670 --> 00:01:55,650
+أو نحن نتحدث عن موضوع محدد أو المستقبل بشكل عام؟
+
+17
+00:01:55,650 --> 00:01:58,830
+يمكنك
+
+18
+00:01:58,830 --> 00:02:02,670
+أن تتحدث عن المستقبل؟ يمكنك أن تتحدث عن نفسك؟
+
+19
+00:02:02,670 --> 00:02:07,510
+أخبرني عن أشياء أخرى، أشياء أخرى التي تستخدمها؟
+
+20
+00:02:15,570 --> 00:02:24,130
+yes please مريدة I will drink water but when I'm
+
+21
+00:02:24,130 --> 00:02:28,990
+thirsty I will drink water thank you good yes Nada
+
+22
+00:02:28,990 --> 00:02:33,730
+I will graduate in 2016 thank you very much okay
+
+23
+00:02:51,480 --> 00:02:57,900
+read the example شيماء thank
+
+24
+00:02:57,900 --> 00:03:04,960
+you will finish is going to finish what is the
+
+25
+00:03:04,960 --> 00:03:09,440
+time here what's the tense express نفين it is
+
+26
+00:03:09,440 --> 00:03:13,020
+future thank you it is future we express the
+
+27
+00:03:13,020 --> 00:03:19,840
+future time it is the symbol future okay
+
+28
+00:03:20,560 --> 00:03:24,500
+الان نستخدم
+
+29
+00:03:24,500 --> 00:03:29,260
+الوضع الواضح ان الوضع الوضع الوضع الوضع الوضع
+
+30
+00:03:29,260 --> 00:03:33,960
+الوضع الوضع الوضع الوضع الوضع الوضع الوضع الوضع
+
+31
+00:03:33,960 --> 00:03:37,220
+الوضع الوضع الوضع الوضع الوضع الوضع الوضع الوضع
+
+32
+00:03:37,220 --> 00:03:47,220
+الوضع الوضع الوضع الوضع الوضع الوضع الوضع الوضع
+
+33
+00:03:47,220 --> 00:03:51,150
+الوضع الوضع الوضع الوضع الوضع الوضعwhat do you
+
+34
+00:03:51,150 --> 00:04:01,850
+think of this sentence if I say she will what
+
+35
+00:04:01,850 --> 00:04:05,410
+do you think of this sentence yes please ياسمين
+
+36
+00:04:05,410 --> 00:04:11,710
+it's wrong why okay
+
+37
+00:04:11,710 --> 00:04:19,420
+so we say whatshe will buy she
+
+38
+00:04:19,420 --> 00:04:25,820
+eats she can eat right she goes she would go and
+
+39
+00:04:25,820 --> 00:04:37,420
+so on now she what
+
+40
+00:04:37,420 --> 00:04:40,340
+do you think of this sentence what do you think of
+
+41
+00:04:40,340 --> 00:04:41,620
+this sentence yes again
+
+42
+00:04:47,300 --> 00:04:52,200
+Okay well does not accept the S right as S does
+
+43
+00:04:52,200 --> 00:04:59,280
+not accept well does not accept this she what
+
+44
+00:04:59,280 --> 00:05:02,160
+do you think of this sentence again yes please
+
+45
+00:05:02,160 --> 00:05:05,440
+read it read it
+
+46
+00:05:10,110 --> 00:05:15,070
+Okay two should be what deleted should be removed
+
+47
+00:05:15,070 --> 00:05:31,010
+so two is not used with well good Read
+
+48
+00:05:31,010 --> 00:05:32,550
+the first example please
+
+49
+00:05:35,690 --> 00:05:39,390
+Okay thank you انا will come this is not accepted
+
+50
+00:05:39,390 --> 00:05:43,690
+this is not accepted this is also what okay this
+
+51
+00:05:43,690 --> 00:05:47,890
+is also not accepted good now read this please
+
+52
+00:05:47,890 --> 00:05:52,250
+نجوة okay
+
+53
+00:05:52,250 --> 00:05:56,090
+prediction we expect something to happen we'll
+
+54
+00:05:56,090 --> 00:06:00,330
+come we'll buy we'll go we'll arrive okay go on
+
+55
+00:06:08,290 --> 00:06:11,530
+Okay thank you a simple form of the verb can you
+
+56
+00:06:11,530 --> 00:06:16,970
+give me an example simple form of a verb yeah a
+
+57
+00:06:16,970 --> 00:06:20,510
+simple form of a verb just one verb in the simple
+
+58
+00:06:20,510 --> 00:06:25,270
+form right good okay eat thank you very much
+
+59
+00:06:25,270 --> 00:06:29,970
+that's right now if i want to make this sentence
+
+60
+00:06:29,970 --> 00:06:31,810
+negative i say
+
+61
+00:06:38,340 --> 00:06:44,480
+والعالية لن تشتغل كذلك. يمكننا أيضًا أن نكتبها
+
+62
+00:06:44,480 --> 00:06:49,680
+بطريقة قصيرة ومشغولة بكتابة ما تريد. لن تشتغل.
+
+63
+00:06:53,200 --> 00:06:58,040
+هل ستأتي
+
+64
+00:06:58,040 --> 00:07:05,210
+إلى هذا الغرفة غدا؟هل ستأتي إلى هذا الغرفة غدا؟
+
+65
+00:07:05,210 --> 00:07:15,890
+اوه حسنًا من يتحدث؟ لا لن أفعل هل ستأتي؟ هل ستزور
+
+66
+00:07:15,890 --> 00:07:24,710
+أختك الليلة؟ لا لن أفعل أو سأفعل؟ نحن نستخدم will
+
+67
+00:07:24,710 --> 00:07:33,330
+لماذا نستخدم will هنا؟ لنسأل عن ماذا؟في مؤتمرات
+
+68
+00:07:33,330 --> 00:07:36,430
+مستقبلية حسنا انها مؤتمرات مستقبلية حسنا انها
+
+69
+00:07:36,430 --> 00:07:38,010
+مؤتمرات مستقبلية حسنا انها مؤتمرات مستقبلية حسنا
+
+70
+00:07:38,010 --> 00:07:46,970
+انها مؤتمرات مستقبلية حسنا انها مؤتمرات مستقبلية
+
+71
+00:07:58,030 --> 00:08:05,410
+هل تأتي هنا بفضل الله؟ هل تأتي هنا بفضل الله؟
+
+72
+00:08:05,410 --> 00:08:10,030
+انتظر انا لا استطيع ان اقول هنا تأتي هنا بفضل الله
+
+73
+00:08:10,030 --> 00:08:12,370
+او انا لا استطيع ان اقول هنا تأتي هنا بفضل الله
+
+74
+00:08:12,370 --> 00:08:16,290
+صح؟ تأتي هنا بفضل الله هل هذا طريقة جيدة لتتحدث مع
+
+75
+00:08:16,290 --> 00:08:20,290
+الناس مثل ذلك؟ لا ماهي أفضل ان تقول تأتي هنا بفضل
+
+76
+00:08:20,290 --> 00:08:24,010
+الله او هل تأتي هنا بفضل الله؟ حسنا هل تأتي هنا
+
+77
+00:08:24,010 --> 00:08:28,330
+بفضل الله؟ ماهي أكتر شخصية أو ماهي أكتر شخصية؟الأن
+
+78
+00:08:28,330 --> 00:08:35,530
+نستخدم will لتطلب المعلومات عن المستقبل و لتطلب
+
+79
+00:08:35,530 --> 00:08:42,330
+مطالبة. الآن أنت في الكفتيريا و تريد بعض الشاي،
+
+80
+00:08:42,330 --> 00:08:47,630
+ماذا ستقول للطبيب؟ من هو المتحد؟ من هو المتحد؟ هل
+
+81
+00:08:47,630 --> 00:08:50,650
+يمكنك أن تعطيني بعض الشاي؟ عظيم، عفوا، هل يمكنك أن
+
+82
+00:08:50,650 --> 00:08:54,110
+تعطيني بعض الشاي؟ عفوا، عفوا، عفوا، عفوا، عفوا،
+
+83
+00:08:54,110 --> 00:08:55,910
+عفوا، عفوا، عفوا، عفوا، عفوا، عفوا، عفوا، عفوا،
+
+84
+00:08:55,910 --> 00:08:55,990
+عفوا، عفوا، عفوا، عفوا، عفوا، عفوا، عفوا، عفوا،
+
+85
+00:08:55,990 --> 00:08:56,470
+عفوا، عفوا، عفوا، عفوا، عفوا، عفوا، عفوا،
+
+86
+00:08:59,800 --> 00:09:04,840
+هل ستفتح البوابة؟ شكرا جزيلا نستخدمها لإطلاق إطلاق
+
+87
+00:09:04,840 --> 00:09:11,880
+مصطلح . الأن في اللغة الإنجليزية الناس اللي بتتكلم
+
+88
+00:09:11,880 --> 00:09:15,520
+بشكل عام يعملوا إتجارات يريدون أن يكونوا سريعين
+
+89
+00:09:17,820 --> 00:09:22,400
+يقولون حسنًا، ليسوا يدفعون كلمة طويلة، فهي مفرومة
+
+90
+00:09:22,400 --> 00:09:27,840
+في الكلام كما ترى، وخصوصًا مع إسماء، خصوصًا مع
+
+91
+00:09:27,840 --> 00:09:32,320
+إسماء، لكنها ممكن تكون مفرومة أيضًا مع إسماء وكلام
+
+92
+00:09:32,320 --> 00:09:38,740
+آخر، لكن هذا ليس عاملًاهذا غير عشوائي ، لذلك عادةً
+
+93
+00:09:38,740 --> 00:09:41,240
+.. انظر ، هذا كتابة غير عشوائية ، كتابة غير
+
+94
+00:09:41,240 --> 00:09:45,340
+عشوائية تكتب لصديقك ، على سبيل المثال تكتب رسالة
+
+95
+00:09:45,340 --> 00:09:50,920
+لصديقك ، أنت ترسل هنا بعض الأكتبار ، تستخدم طريقة
+
+96
+00:09:50,920 --> 00:09:54,620
+غير عشوائية للكتابة ، يمكنك أن تقوم بإتصال ، ولكن
+
+97
+00:09:54,620 --> 00:09:58,360
+كتابة غير عشوائية عندما تكتب رسالة ، على سبيل
+
+98
+00:09:58,360 --> 00:10:02,750
+المثال ، تقوم ببحثاكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟
+
+99
+00:10:02,750 --> 00:10:05,750
+اكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟
+
+100
+00:10:05,750 --> 00:10:13,170
+اكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟
+
+101
+00:10:13,170 --> 00:10:16,490
+اكيد؟ اكيد؟ اكيد؟
+
+102
+00:10:16,490 --> 00:10:20,330
+اكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟
+
+103
+00:10:20,330 --> 00:10:20,530
+اكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟
+
+104
+00:10:20,530 --> 00:10:21,150
+اكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟
+
+105
+00:10:21,150 --> 00:10:25,020
+اكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟ اكيد؟نحن
+
+106
+00:10:25,020 --> 00:10:30,020
+نصنع اتصالات ولكن هذا ماذا مرة أخرى؟ هذا غير عميق،
+
+107
+00:10:30,020 --> 00:10:36,400
+هذا غير عميق، إذا كنت تكتب، يجب أن تكتب بطريقة
+
+108
+00:10:36,400 --> 00:10:38,120
+عامة، كتب بطريقة عامة، كتب بطريقة عامة، كتب بطريقة
+
+109
+00:10:38,120 --> 00:10:38,320
+عامة، كتب بطريقة عامة، كتب بطريقة عامة، كتب بطريقة
+
+110
+00:10:38,320 --> 00:10:39,860
+عامة، كتب بطريقة عامة، كتب بطريقة عامة، كتب بطريقة
+
+111
+00:10:39,860 --> 00:10:42,280
+عامة، كتب بطريقة عامة، كتب بطريقة عامة، كتب بطريقة
+
+112
+00:10:42,280 --> 00:10:49,300
+عامة، كتب بطريقة عامة، كتب بطريقة عامة،
+
+113
+00:10:49,300 --> 00:10:53,720
+كتب بطcan be .. will can be contracted with other
+
+114
+00:10:53,720 --> 00:10:56,980
+words look it can be contracted with the pronouns
+
+115
+00:10:56,980 --> 00:11:00,900
+okay it can be contracted with their can be
+
+116
+00:11:00,900 --> 00:11:04,520
+contracted with nobody can be contracted with that
+
+117
+00:11:04,520 --> 00:11:09,220
+but this is again what this is informal this is
+
+118
+00:11:09,220 --> 00:11:17,180
+informal yeah
+
+119
+00:11:17,180 --> 00:11:20,680
+can you read the example pleaseأنا is going to
+
+120
+00:11:20,680 --> 00:11:29,240
+come tomorrow around five o'clock okay that's
+
+121
+00:11:29,240 --> 00:11:32,340
+right this is informally especially american
+
+122
+00:11:32,340 --> 00:11:36,380
+especially american english they don't say going
+
+123
+00:11:36,380 --> 00:11:40,500
+to going to this is formal you use in writing but
+
+124
+00:11:40,500 --> 00:11:43,640
+if you are talking to people there they say what
+
+125
+00:11:43,640 --> 00:11:49,470
+who can who can read it amnesiathat's right أنا is
+
+126
+00:11:49,470 --> 00:11:53,890
+gonna okay come tomorrow so this is going to this
+
+127
+00:11:53,890 --> 00:12:00,230
+is the way we read this construction okay so again
+
+128
+00:12:00,230 --> 00:12:04,610
+going to how do we pronounce it read it again
+
+129
+00:12:04,610 --> 00:12:10,870
+please thank you
+
+130
+00:12:10,870 --> 00:12:12,850
+thank you again please thank you
+
+131
+00:12:18,040 --> 00:12:26,840
+الأن عندما أقول علي لن يأتي، علي لن يأتي، هذا
+
+132
+00:12:26,840 --> 00:12:36,240
+ماذا؟ نقاط، إذا أردت أن أتسأل، هل علي سيأتي؟
+
+133
+00:12:36,240 --> 00:12:42,440
+هل ستأتي إلى هذا الغرفة غدا؟هل ستأتي إلى هذه
+
+134
+00:12:42,440 --> 00:12:46,240
+الغرفة غضبًا؟ لا، حسنًا، لذلك going to يمكن
+
+135
+00:12:46,240 --> 00:12:49,960
+استخدامها أيضًا لإصلاح السؤالات ويمكن استخدامها
+
+136
+00:12:49,960 --> 00:12:58,460
+لإصلاح ما؟ الواقع المفارق، جيد، الأن will و going
+
+137
+00:12:58,460 --> 00:13:03,440
+to ماهي الفرق بينهم؟ في الجزء السابق، قالنا أن
+
+138
+00:13:03,440 --> 00:13:09,770
+كلاهم استخداموا التحدث عن ماذا؟ الجنرال، نعمفي
+
+139
+00:13:09,770 --> 00:13:13,910
+المستقبل في المستقبل
+
+140
+00:13:13,910 --> 00:13:19,370
+إذا كنت ترغب في تخطيط حدث ماذا يحدث؟ نحن نستطيع
+
+141
+00:13:19,370 --> 00:13:23,490
+تخطيط هذا الحدث في المستقبل باستخدام will أو going
+
+142
+00:13:23,490 --> 00:13:30,930
+to هي ستشتري وهي ستشتري الآن ماهي الفرق بين will و
+
+143
+00:13:30,930 --> 00:13:35,750
+going to؟ هل هناك اي فرق بينهم؟ نعم بالطبع نحن
+
+144
+00:13:35,750 --> 00:13:39,900
+نريد أن نلعب لعبةنحن نريد أن نلعب لعبة، من يريد
+
+145
+00:13:39,900 --> 00:13:49,340
+اللعب؟ تعال بفضل الله هل
+
+146
+00:13:49,340 --> 00:13:54,680
+يمكنك أن تنتظر في الخارج فقط 4 دقيقة و سنتصل بك
+
+147
+00:13:54,680 --> 00:14:03,220
+اسمع،
+
+148
+00:14:03,220 --> 00:14:09,650
+نريد أن نجعل حفلةماذا تفكر بالفكرة؟ نحن نريد أن
+
+149
+00:14:09,650 --> 00:14:13,430
+نكون في حفلة. ماذا تفكر بالفكرة؟ فكرة جيدة. حسنًا،
+
+150
+00:14:13,430 --> 00:14:16,530
+من يريد أن يكون معنا؟ هل تريد أن تأتي؟ حسنًا،
+
+151
+00:14:16,530 --> 00:14:22,850
+فماذا نحتاج للحفلة؟ ماذا نحتاج؟ كيك. جيد. و؟
+
+152
+00:14:22,850 --> 00:14:25,170
+حلوات. حلوات.
+
+153
+00:14:27,920 --> 00:14:32,320
+حلوات جيدة جدا هذا صح شكرا جزيلا هذا يكفي نحن نريد
+
+154
+00:14:32,320 --> 00:14:37,640
+حفلة بسيطة ليست حفلة كبيرة جدا حسنا نحن نريد أحد
+
+155
+00:14:37,640 --> 00:14:45,600
+يحضر كيك نحن نريد أحد يحضر كيك نعم إسمك كريمان
+
+156
+00:14:45,600 --> 00:14:54,760
+كريمان نعم كريمان أسمع كريمان انا
+
+157
+00:14:57,430 --> 00:15:05,290
+أنا سأ .. انا سأ .. انا سأ .. انا سأ .. انا سأ ..
+
+158
+00:15:05,290 --> 00:15:07,510
+انا سأ .. انا سأ .. انا سأ .. انا سأ .. انا سأ ..
+
+159
+00:15:07,510 --> 00:15:07,570
+انا سأ .. انا سأ .. انا سأ .. انا سأ .. انا سأ ..
+
+160
+00:15:07,570 --> 00:15:07,630
+انا سأ .. انا سأ .. انا سأ .. انا سأ .. انا سأ ..
+
+161
+00:15:07,630 --> 00:15:07,650
+انا سأ .. انا سأ .. انا سأ .. انا سأ .. انا سأ ..
+
+162
+00:15:07,650 --> 00:15:07,710
+انا سأ .. انا سأ .. انا سأ .. انا سأ .. انا سأ ..
+
+163
+00:15:07,710 --> 00:15:09,790
+انا سأ .. انا سأ .. انا سأ .. انا سأ .. انا سأ ..
+
+164
+00:15:09,790 --> 00:15:17,490
+انا سأ .. انا سأ .. انا سأ .. انا سأ ..
+
+165
+00:15:17,490 --> 00:15:20,010
+انا سأ
+
+166
+00:15:26,150 --> 00:15:35,470
+thank you و لا و لا says I will bring flowers okay
+
+167
+00:15:35,470 --> 00:15:40,050
+call موريدا please call call here
+
+168
+00:15:52,140 --> 00:15:55,480
+حسنًا يا مريدا، نحن نخطط أن نجعل حفلة، نريد أن
+
+169
+00:15:55,480 --> 00:15:59,020
+يكون هناك حفلة في المدرسة و سيكون رائع إن كنت
+
+170
+00:15:59,020 --> 00:16:02,800
+تتجمد معنا، هل ترغبين أن تأتي معنا؟ نعم أتمنى حفلة
+
+171
+00:16:02,800 --> 00:16:07,640
+جيدة، الآن لحفلة نحتاج إلى كيك و أشياء و أشجار
+
+172
+00:16:07,640 --> 00:16:13,640
+حسنًا، هل انت مستعد أن تحضر شيء؟ انا مستعد ان احضر
+
+173
+00:16:13,640 --> 00:16:17,500
+شيء انا
+
+174
+00:16:17,500 --> 00:16:23,690
+مستعد ان احضر كيكI'm going to make a cake shall
+
+175
+00:16:23,690 --> 00:16:31,690
+she say I'm going to yes or no no why not because
+
+176
+00:16:31,690 --> 00:16:35,550
+you're asking her now now I'm asking her so now
+
+177
+00:16:35,550 --> 00:16:39,570
+what did carrie man say for the first time I will
+
+178
+00:16:39,570 --> 00:16:44,510
+I will now it's new for her so she she's this
+
+179
+00:16:44,510 --> 00:16:48,650
+she's deciding now so what shall she say I will
+
+180
+00:16:49,460 --> 00:16:56,320
+Okay مريدا says I will bring cakes كريمان what do
+
+181
+00:16:56,320 --> 00:17:02,600
+you say now؟فقط لحظة، في الأول مرة تقولت أنا
+
+182
+00:17:02,600 --> 00:17:08,400
+سأحضر، حسنا؟ و الأن نحن قررنا الأحداث، نحن اتفقنا،
+
+183
+00:17:08,400 --> 00:17:10,840
+حسنا؟ نحن قررنا الأحداث، حسنا؟ نحن قررنا الأحداث،
+
+184
+00:17:10,840 --> 00:17:12,440
+حسنا؟ نحن قررنا الأحداث، حسنا؟ نحن قررنا الأحداث،
+
+185
+00:17:12,440 --> 00:17:13,720
+حسنا؟ نحن قررنا الأحداث، حسنا؟ نحن قررنا الأحداد،
+
+186
+00:17:13,720 --> 00:17:19,400
+حسنا؟ نحن قررنا الأحداد، حسنا؟ نحن قررنا الأحداد،
+
+187
+00:17:19,400 --> 00:17:25,300
+حسنا؟ نحن قررنا الأحداد، حسلا تخطيط التخطيط. ماذا
+
+188
+00:17:25,300 --> 00:17:27,640
+استخدمنا؟ ماذا استخدمنا؟ ماذا استخدمنا؟ ماذا
+
+189
+00:17:27,640 --> 00:17:27,780
+استخدمنا؟ ماذا استخدمنا؟ ماذا استخدمنا؟ ماذا
+
+190
+00:17:27,780 --> 00:17:28,260
+استخدمنا؟ ماذا استخدمنا؟ ماذا استخدمنا؟ ماذا
+
+191
+00:17:28,260 --> 00:17:29,960
+استخدمنا؟ ماذا استخدمنا؟ ماذا استخدمنا؟ ماذا
+
+192
+00:17:29,960 --> 00:17:35,720
+استخدمنا؟ ماذا استخدمنا؟ ماذا
+
+193
+00:17:35,720 --> 00:17:40,600
+استخدمنا؟ ماذا استخدمنا؟ ماذا استخدمنا؟ ماذا
+
+194
+00:17:40,600 --> 00:17:41,360
+استخدمنا؟ ماذا استخدمنا؟ ماذا استخدمنا؟ ماذا
+
+195
+00:17:41,360 --> 00:17:46,580
+استخدمنا؟ ماذا استخدمنا؟ ماذا استخدمنا؟ ماذا
+
+196
+00:17:46,580 --> 00:17:51,140
+است
+
+197
+00:17:51,240 --> 00:17:59,700
+ماذا تقول ندا؟ أين ندا؟ إسمع، إسمع ندا. ندا ستحضر.
+
+198
+00:17:59,920 --> 00:18:04,200
+نحن نريد الزهر يا مريدة. سأحضر بعض.
+
+199
+00:18:08,860 --> 00:18:14,460
+أنا سأحضر .. نعم نعم لا و لا هي ستحضر .. حسنا الان
+
+200
+00:18:14,460 --> 00:18:20,540
+مريدة شكرا جزيلا كريمان هي ستحضر كيك و نادا هي
+
+201
+00:18:20,540 --> 00:18:25,040
+ستحضر أشياء و ولا هي ستحضر أشياء نحتاج إلى بعض
+
+202
+00:18:25,040 --> 00:18:32,320
+الطعام نحتاج إلى بعض الطعام سأحضر .. سأحضر حسنا
+
+203
+00:18:32,320 --> 00:18:34,180
+شكرا جزيلا إجلس
+
+204
+00:18:36,700 --> 00:18:40,400
+what's the difference between will and going to?
+
+205
+00:18:40,580 --> 00:18:43,240
+when do we use this and when do we use that? yeah
+
+206
+00:18:43,240 --> 00:18:48,680
+pre
+
+207
+00:18:48,680 --> 00:18:51,180
+planning okay pre planning good
+
+208
+00:18:54,590 --> 00:18:58,430
+Okay if there is preplanning, we use what? Going
+
+209
+00:18:58,430 --> 00:19:02,850
+to. No preplanning, just you decide just now. We
+
+210
+00:19:02,850 --> 00:19:08,230
+use what? The weather is hot. It's hot. It's hot.
+
+211
+00:19:09,830 --> 00:19:12,490
+The weather is hot. Look it's a very hot room.
+
+212
+00:19:13,350 --> 00:19:17,690
+What do you say? I will. Yeah, who's the speaker?
+
+213
+00:19:18,170 --> 00:19:25,290
+Who's the speaker? Yeahit's I will I will open the
+
+214
+00:19:25,290 --> 00:19:28,530
+window very good I will open the window I'm
+
+215
+00:19:28,530 --> 00:19:35,010
+thirsty I need some water I will bring water I'm
+
+216
+00:19:35,010 --> 00:19:37,070
+very hungry I didn't have breakfast
+
+217
+00:19:39,970 --> 00:19:46,210
+سأحضرك سأحضرك حسنا؟ سأحضرك الأن كنت تريد أن تغادر
+
+218
+00:19:46,210 --> 00:19:53,610
+المنزل فجأة اكتشفت أنه يتحرك انت قلت انا سأخذ ..
+
+219
+00:19:53,610 --> 00:19:56,770
+انا سأخذ .. انا سأخذ .. انا سأخد .. انا سأخد ..
+
+220
+00:19:56,770 --> 00:20:00,430
+انا سأخد .. انا سأخد .. انا سأخد .. انا سأخد ..
+
+221
+00:20:00,430 --> 00:20:02,410
+انا سأخد .. انا سأخد .. انا سأخد .. انا سأخد ..
+
+222
+00:20:02,410 --> 00:20:02,590
+انا سأخد .. انا سأخد .. انا سأخد .. انا سأخد ..
+
+223
+00:20:02,590 --> 00:20:04,990
+انا سأخد .. انا سأخد .. انا سأخد .. انا سأخد ..
+
+224
+00:20:04,990 --> 00:20:10,130
+انا سأخد .. انا سأخد .. انا سI'm going to .. good
+
+225
+00:20:10,130 --> 00:20:26,890
+thank you would
+
+226
+00:20:26,890 --> 00:20:35,590
+you please read سوحى okay it is not there okay
+
+227
+00:20:37,870 --> 00:20:46,390
+Prediction according to the weather report it
+
+228
+00:20:46,390 --> 00:20:49,870
+is going to be cloudy tonight Thank you it's going
+
+229
+00:20:49,870 --> 00:20:52,610
+to be cloudy it will be cloudy this is what
+
+230
+00:20:52,610 --> 00:20:56,990
+prediction okay they predict they expect something
+
+231
+00:20:56,990 --> 00:21:00,750
+to happen okay so when we talk about predictions
+
+232
+00:21:00,750 --> 00:21:01,930
+you can use what
+
+233
+00:21:05,810 --> 00:21:14,430
+ممكن تخبرني عن نفسك؟ ممكن تخبرني عن نفسك؟ نعم بفضل
+
+234
+00:21:14,430 --> 00:21:18,790
+الله شكرا
+
+235
+00:21:18,790 --> 00:21:26,650
+جدا انا هانا هانا هانا هانا هانا هانا هانا هانا
+
+236
+00:21:26,650 --> 00:21:31,830
+هانا هانا هانا هانا هانا هانا هانا هانا هانا هانا
+
+237
+00:21:31,830 --> 00:21:32,370
+هانا هانا هانا هانا هانا هانا هانا هانا هانا هانا
+
+238
+00:21:32,370 --> 00:21:32,570
+هانا هانا هانا هانا هانا هانا هانا هانا هانا هانا
+
+239
+00:21:32,570 --> 00:21:39,860
+هانا هانا هانا هانا هانولا نتكلم عن حدوث خاصة، بل
+
+240
+00:21:39,860 --> 00:21:41,540
+نتكلم عن حدوث عامة، نتكلم عن حدوث عامة، نتكلم عن
+
+241
+00:21:41,540 --> 00:21:45,440
+حدوث عامة، نتكلم عن حدوث عامة، نتكلم عن حدوث عامة،
+
+242
+00:21:45,440 --> 00:21:47,880
+نتكلم عن حدوث عامة، نتكلم عن حدوث عامة، نتكلم عن
+
+243
+00:21:47,880 --> 00:21:51,320
+حدوث عامة، نتكلم عن حدوث عامة، نتكلم عن حدوث عامة،
+
+244
+00:21:51,320 --> 00:21:51,360
+نتكلم عن حدوث عامة، نتكلم عن حدوث عامة، نتكلم عن
+
+245
+00:21:51,360 --> 00:21:53,440
+حدوث عامة، نتكلم عن حدوث عامة، نتكلم عن حدوث عامة،
+
+246
+00:21:53,440 --> 00:21:55,640
+نتكلم عن حدوث عامة
+
+247
+00:21:57,850 --> 00:22:03,710
+الأن، يا عزيزي، اقرأ. سنقوم بقصدهم عندما يقوموا
+
+248
+00:22:03,710 --> 00:22:10,030
+بالتخطيطات حول الموضوع. التخطيطات هي مقالات عن شيء
+
+249
+00:22:10,030 --> 00:22:13,650
+غير صحيح. الأشياء ستكون حقيقية أو ستحدث في
+
+250
+00:22:13,650 --> 00:22:17,910
+الموضوع. شكرا جزيلا. الشمس ستكون جميلة الأسبوع
+
+251
+00:22:17,910 --> 00:22:23,590
+التالي. الشمس ستكون جميلة الأسبوع التالي. نحن
+
+252
+00:22:23,590 --> 00:22:26,350
+نتوقع شيء يحدث.
+
+253
+00:22:34,220 --> 00:22:39,740
+الأن دعاء تحصل على الكثير من الكتب في صندوقها،
+
+254
+00:22:39,740 --> 00:22:45,360
+انظر، هي تحصل على صندوق كبير مليء بالكتب، لماذا
+
+255
+00:22:45,360 --> 00:22:52,540
+أحضرت كل الكتب دعاء؟ هي ترغب في الذهاب إلى المسجد
+
+256
+00:22:52,540 --> 00:22:55,780
+للدراسة، ماذا تقول؟
+
+257
+00:22:58,640 --> 00:23:01,380
+I'm going to stay in the library thank you very
+
+258
+00:23:01,380 --> 00:23:06,380
+much I'm going to stay okay in the library have
+
+259
+00:23:06,380 --> 00:23:10,300
+you heard راندا your friend is tired she was
+
+260
+00:23:10,300 --> 00:23:16,680
+admitted to the hospital in the morning again
+
+261
+00:23:16,680 --> 00:23:23,690
+I I willسأقوم بالزيارة هنا شكرا جزيلا نفين هل
+
+262
+00:23:23,690 --> 00:23:29,270
+تقرأ؟ لماذا أشتريت هذه اللوحة؟ سأرسم بيتي غير غير
+
+263
+00:23:29,270 --> 00:23:29,770
+غير غير غير غير غير غير غير غير غير غير غير غير
+
+264
+00:23:29,770 --> 00:23:33,070
+غير غير غير غير غير غير غير غير غير غير غير غير
+
+265
+00:23:33,070 --> 00:23:33,150
+غير غير غير غير غير غير غير غير غير غير غير غير
+
+266
+00:23:33,150 --> 00:23:34,350
+غير غير غير غير غير غير غير غير غير غير غير غير
+
+267
+00:23:34,350 --> 00:23:36,590
+غير غير غير غير غير غير غير غير غير غير غير غير
+
+268
+00:23:36,590 --> 00:23:36,610
+غير غير غير غير غير غير غير غير غير غير غير غير
+
+269
+00:23:36,610 --> 00:23:38,090
+غير غير غير غير غير غير غير غير غير غير غير غير
+
+270
+00:23:38,090 --> 00:23:48,910
+غير
+
+271
+00:23:48,910 --> 00:23:55,070
+غيرa prior,
+
+272
+00:23:55,410 --> 00:24:02,890
+a pre, before, okay plan, yeah okay
+
+273
+00:24:02,890 --> 00:24:06,550
+what is the plan? painting what? the bedroom,
+
+274
+00:24:06,770 --> 00:24:13,530
+painting the bedroom now أحلام is having a lot of
+
+275
+00:24:13,530 --> 00:24:19,530
+money todayتريد الذهاب للشواء. يمكنها أن تقول انا
+
+276
+00:24:19,530 --> 00:24:21,470
+سأذهب للشواء بعد الدراسة.
+
+277
+00:24:24,910 --> 00:24:30,950
+لذلك هل حدثت برنامجها؟ نعم. جلبت بعض المال. جلبت
+
+278
+00:24:30,950 --> 00:24:34,970
+الكثير من المال. حسنًا، لذا هي ذاهبة أيضًا. هي
+
+279
+00:24:34,970 --> 00:24:37,750
+ذاهبة أيضًا. حسنًا، جيد.
+
+280
+00:24:46,200 --> 00:24:51,420
+I need somebody to help me carry this table I need
+
+281
+00:24:51,420 --> 00:24:55,900
+somebody to help me I need your help okay I will
+
+282
+00:24:55,900 --> 00:25:00,720
+good thank you I will okay who can bring me some
+
+283
+00:25:00,720 --> 00:25:08,550
+teaI will يعني انا مستعد انا مستعد انا مستعد انا
+
+284
+00:25:08,550 --> 00:25:11,270
+مستعد انا مستعد انا مستعد انا مستعد انا مستعد انا
+
+285
+00:25:11,270 --> 00:25:11,930
+مستعد انا مستعد انا مستعد انا مستعد انا مستعد انا
+
+286
+00:25:11,930 --> 00:25:12,290
+مستعد انا مستعد انا مستعد انا مستعد انا مستعد انا
+
+287
+00:25:12,290 --> 00:25:12,710
+مستعد انا مستعد انا مستعد انا مستعد انا مستعد انا
+
+288
+00:25:12,710 --> 00:25:13,150
+مستعد انا مستعد انا مستعد انا مستعد انا مستعد انا
+
+289
+00:25:13,150 --> 00:25:13,230
+مستعد انا مستعد انا مستعد انا مستعد انا مستعد انا
+
+290
+00:25:13,230 --> 00:25:14,150
+مستعد انا مستعد انا مستعد انا مستعد انا مستعد انا
+
+291
+00:25:14,150 --> 00:25:18,850
+مستعد انا مستعد انا مستعد انا مستعد انا مستعد انا
+
+292
+00:25:18,850 --> 00:25:23,030
+مستعد
+
+293
+00:25:31,590 --> 00:25:36,170
+Okay good that's right thank you okay thank you
+
+294
+00:25:36,170 --> 00:25:42,690
+request you mean okay polite request and asking
+
+295
+00:25:42,690 --> 00:25:52,270
+forمعلومات و ماذا؟ مقررانة مقررانة انا مقرر ان انا
+
+296
+00:25:52,270 --> 00:25:59,150
+مستعد لفعلها الهاتف يتصل الهاتف يتصل انا سأحصل
+
+297
+00:25:59,150 --> 00:26:05,150
+عليه انا سأحصل عليه حسنا؟ الان متى قرر الاسمعي؟
+
+298
+00:26:05,150 --> 00:26:11,970
+الان فقط في الانتقال الانتقال جيد جدا فقط الانولم
+
+299
+00:26:11,970 --> 00:26:17,210
+يقرروا قبل ذلك. لا يوجد تخطيط قبل ذلك. ليس الأن.
+
+300
+00:26:18,230 --> 00:26:23,230
+ليس قبل ذلك. أسف. الأن فقط فعلوا. لذا مرة أخرى
+
+301
+00:26:23,230 --> 00:26:26,970
+عندما أقول أنني أحتاج أحد ليساعدني، تقول انا
+
+302
+00:26:26,970 --> 00:26:32,990
+سأساعدك. سأساعدك. أنا مستعد لإساعدك. لا تقول أنا
+
+303
+00:26:32,990 --> 00:26:34,410
+سأفعل أيضًا.
+
+304
+00:26:47,320 --> 00:26:55,700
+الان نيفين هل ستجيب طلابك كل طلابك لطيابة بعد هذه
+
+305
+00:26:55,700 --> 00:27:01,520
+الدراسة؟ نعم سوف أفعل ذلك حقا؟ هل ستفعل ذلك؟ نعم
+
+306
+00:27:01,520 --> 00:27:06,620
+هل لديك الكثير من المال؟ نعم جيد حسنا، نعم سوف
+
+307
+00:27:06,620 --> 00:27:10,320
+أفعل ذلك هي مستعدة، هذا هو الوظيفة، جيد شكرا جزيلا
+
+308
+00:27:10,320 --> 00:27:15,700
+لك، إذا كنت تستطيع أن تجيبهم لطيابةأنت يجب أن
+
+309
+00:27:15,700 --> 00:27:20,320
+تجلبهم لطعام أيضًا و انا لن أذهب حقًا ستفعل، لذا
+
+310
+00:27:20,320 --> 00:27:24,980
+سنبحث عن طلاب آخر، شكرا جزيلا لك حسنًا، نادا ليس
+
+311
+00:27:24,980 --> 00:27:28,700
+لديها أموال، حسنًا؟ ليس لديها أموال، لديها فقط
+
+312
+00:27:28,700 --> 00:27:33,640
+قليل من الأموال، لديها قليل من الأموال. الأن نادا،
+
+313
+00:27:33,640 --> 00:27:43,640
+هل تجلب طلابك لطعام اليوم؟لأ اريد لأ اريد لأ اريد
+
+314
+00:27:43,640 --> 00:27:48,460
+لأ اريد لأ اريد
+
+315
+00:27:48,460 --> 00:27:53,260
+لأ
+
+316
+00:27:53,260 --> 00:27:59,120
+اريد
+
+317
+00:27:59,120 --> 00:28:06,140
+لأ اريد
+
+318
+00:28:07,090 --> 00:28:11,370
+لا اريد هل ستأتي إلى المدرسة في اليوم الجمعي؟ لا
+
+319
+00:28:11,370 --> 00:28:22,110
+اريد نعم نعم
+
+320
+00:28:22,110 --> 00:28:23,530
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+321
+00:28:23,530 --> 00:28:23,590
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+322
+00:28:23,590 --> 00:28:24,230
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+323
+00:28:24,230 --> 00:28:25,190
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+324
+00:28:25,190 --> 00:28:25,850
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+325
+00:28:25,850 --> 00:28:34,790
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+326
+00:28:34,790 --> 00:28:47,150
+نعمI say she want I want we use it for human can
+
+327
+00:28:47,150 --> 00:28:52,610
+we use want for things for non-human yes okay we
+
+328
+00:28:52,610 --> 00:28:55,650
+can use it for non-human read please randa
+
+329
+00:29:01,300 --> 00:29:04,600
+Okay thank you so want is also used for what
+
+330
+00:29:04,600 --> 00:29:10,300
+things for non human not only for people okay now
+
+331
+00:29:10,300 --> 00:29:18,580
+read this point please yes you there read it
+
+332
+00:29:18,580 --> 00:29:19,320
+willingness
+
+333
+00:29:35,080 --> 00:29:38,560
+Okay thank you. Who can explain this point? What
+
+334
+00:29:38,560 --> 00:29:41,660
+does that mean? We talked about this just minutes
+
+335
+00:29:41,660 --> 00:29:46,660
+before. Who can explain this point? Yes please
+
+336
+00:29:46,660 --> 00:29:53,680
+Nadaإذا كنا نخطط لحدث نستخدم going to لكن إذا لم
+
+337
+00:29:53,680 --> 00:29:58,120
+نخطط و نخطط حاليا نستخدم when. أنت محق لكن هنا هو
+
+338
+00:29:58,120 --> 00:30:01,860
+يريد شيء أخر. الأن اسمع أنا أريد شخص ما يساعدني.
+
+339
+00:30:02,980 --> 00:30:08,040
+سأفعل. لا تقولي أنا سأفعل. حسنا؟ لذلك مرة أخرى
+
+340
+00:30:08,040 --> 00:30:13,240
+لأنه لا يوجد تخطيط تخطيط تخطيط تخطيط تخطيط تخطيط
+
+341
+00:30:13,240 --> 00:30:17,620
+تخطيط تخطيط تخطيط تخطيط تخطيط
+
+342
+00:30:25,960 --> 00:30:32,000
+الأن، انظر إلى هذه الكلمات،
+
+343
+00:30:32,000 --> 00:30:36,580
+نعم،
+
+344
+00:30:36,580 --> 00:30:40,980
+من يريد أن يقرأ؟ نعم، لازم تقرأها ليندا ستقرأ قصة
+
+345
+00:30:40,980 --> 00:30:47,480
+اسمها بكبارbefore she leaves she is going to
+
+346
+00:30:47,480 --> 00:30:51,900
+finish her work thank you look before she leaves
+
+347
+00:30:51,900 --> 00:30:58,720
+okay she is going to finish her work look this is
+
+348
+00:30:58,720 --> 00:31:03,240
+one clause and this is another clause this is the
+
+349
+00:31:03,240 --> 00:31:08,400
+main clause she is going okay and before she
+
+350
+00:31:08,400 --> 00:31:12,960
+leaves is a time clausethis time a clause begins
+
+351
+00:31:12,960 --> 00:31:17,640
+with what before a word which expresses time read
+
+352
+00:31:17,640 --> 00:31:24,960
+the other sentence please thank
+
+353
+00:31:24,960 --> 00:31:29,480
+you
+
+354
+00:31:29,480 --> 00:31:33,760
+now what's the tense in general what's the tense
+
+355
+00:31:33,760 --> 00:31:38,020
+future future very good look again i have two
+
+356
+00:31:38,020 --> 00:31:43,030
+clauses okayهذه المفهوم الرئيسي وهذه المفهوم
+
+357
+00:31:43,030 --> 00:31:49,710
+الوقتي. إنها تعني ماذا؟ المستقبل. وهذه تعني ماذا؟
+
+358
+00:31:49,710 --> 00:31:57,110
+المستقبل. وهذه، نعم بفضل الله، قم بقراها. السيارة.
+
+359
+00:31:58,650 --> 00:32:03,630
+انظر، نحن نتحدث عن المستقبل. نحن نتحدث عن
+
+360
+00:32:03,630 --> 00:32:04,130
+المستقبل.
+
+361
+00:32:19,410 --> 00:32:23,350
+و أخيرًا الاختصار الأخير
+
+362
+00:32:27,960 --> 00:32:33,020
+شكرًا لكم حتى يأتيوا سأنتظر لدينا اتفاقين اثنين
+
+363
+00:32:33,020 --> 00:32:37,480
+الان عامًا الوقت المظهر في هذه التفاقين في
+
+364
+00:32:37,480 --> 00:32:44,620
+المستقبل حسنًا شكرا لك لدينا انظر لتفاقه الوقتبدا
+
+365
+00:32:44,620 --> 00:32:53,740
+من قبل و بعد و قبل و قبل و قبل و قبل و قبل و قبل و
+
+366
+00:32:53,740 --> 00:32:54,860
+قبل و قبل و قبل و قبل و قبل و قبل و قبل و قبل و
+
+367
+00:32:54,860 --> 00:32:55,920
+قبل و قبل و قبل و قبل و قبل و قبل و قبل و قبل و
+
+368
+00:32:55,920 --> 00:33:00,580
+قبل و قبل و قبل و قبل و قبل و قبل و قبل و قبل و
+
+369
+00:33:00,580 --> 00:33:02,220
+قبل و قبل و قبل و قبل و قبل و قبل و قبل و قبل و
+
+370
+00:33:02,220 --> 00:33:05,200
+قبل و قبل و قبل و قبل و قبل و قبل و قبل و قبل و
+
+371
+00:33:05,200 --> 00:33:11,000
+قبل و قبل و قبل و قبل و قبل و قبل و قبل و قبل و
+
+372
+00:33:11,000 --> 00:33:11,520
+قبل و قبل و قبل و قبل و قبل و قبل و قبل و قبل و
+
+373
+00:33:11,520 --> 00:33:17,240
+قبل و قبل وإذا كنت تذهب إلى مصر، هذا هو المستقبل،
+
+374
+00:33:17,240 --> 00:33:19,840
+ستشاهد الـNile.
+
+375
+00:33:22,160 --> 00:33:28,420
+يمكننا استخدام المستقبل هنا؟ يمكننا استخدام
+
+376
+00:33:28,420 --> 00:33:32,780
+المستقبل في القرص الوقت؟ لا، لذلك القرص الوقت ليس
+
+377
+00:33:32,780 --> 00:33:38,440
+استخدام في المستقبل. المستقبل ليس استخدام في القرص
+
+378
+00:33:38,440 --> 00:33:43,480
+الوقت. نستخدم إسم الحجر لإعطاء ما؟المستقبل، هذا
+
+379
+00:33:43,480 --> 00:33:51,420
+صحيح. عندما تقبلني، سأعود. عندما تسألني، سأجيب.
+
+380
+00:33:53,360 --> 00:34:01,120
+ماذا ستفعل عندما تذهب إلى المطبخ؟ عندما .. عندما
+
+381
+00:34:01,120 --> 00:34:07,120
+.. عندما أذهب إلى المطبخ، سأأكل. ماذا ستفعل عندما
+
+382
+00:34:07,120 --> 00:34:08,280
+تذهب إلى الكتابة؟
+
+383
+00:34:10,920 --> 00:34:17,440
+ماذا ستفعل عندما تذهب إلى السوق؟
+
+384
+00:34:17,440 --> 00:34:22,340
+ماذا ستفعل عندما تذهب إلى
+
+385
+00:34:22,340 --> 00:34:37,780
+السوق؟ ماذا
+
+386
+00:34:37,780 --> 00:34:45,140
+ستفعل عندما تحف المال؟when I save money I will buy
+
+387
+00:34:45,140 --> 00:34:49,000
+a car I
+
+388
+00:34:49,000 --> 00:34:53,160
+will buy a laptop I will buy a new mobile okay
+
+389
+00:34:53,160 --> 00:35:01,000
+good now in these sentences you see we have a time
+
+390
+00:35:01,000 --> 00:35:08,280
+clause and another main clause in the time clause
+
+391
+00:35:08,280 --> 00:35:14,020
+we useالوضع الوضع الوضع الوضع الوضع الوضع الوضع
+
+392
+00:35:14,020 --> 00:35:21,680
+الوضع الوضع الوضع الوضع الوضع الوضع الوضع الوضع
+
+393
+00:35:21,680 --> 00:35:24,860
+الوضع الوضع الوضع الوضع الوضع الوضع الوضع الوضع
+
+394
+00:35:24,860 --> 00:35:24,880
+الوضع الوضع الوضع الوضع الوضع الوضع الوضع الوضع
+
+395
+00:35:24,880 --> 00:35:27,320
+الوضع الوضع الوضع الوضع الوضع الوضع الوضع الوضع
+
+396
+00:35:27,320 --> 00:35:30,680
+الوضع الوضع الوضع الوضع الوضع الوضع الوضع الوضع
+
+397
+00:35:30,680 --> 00:35:40,320
+الوضع
+
+398
+00:35:41,560 --> 00:35:45,700
+When Ali comes, this is what? Present symbol.
+
+399
+00:35:45,780 --> 00:35:50,640
+Where is the time clause? When Ali comes. It is
+
+400
+00:35:50,640 --> 00:35:55,200
+made of a time expressing word and this is what? A
+
+401
+00:35:55,200 --> 00:35:59,800
+subject. And this is what? A verb. And this is a
+
+402
+00:35:59,800 --> 00:36:06,090
+verb.الأن، هل يمكنك أن تفكر في مثالين مشابهين؟
+
+403
+00:36:06,090 --> 00:36:10,770
+استخدم كلمة وقت مع عندك، بعدك، قبلك، قريب منك،
+
+404
+00:36:10,770 --> 00:36:12,310
+كمان كمان كمان كمان كمان كمان كمان كمان كمان كمان
+
+405
+00:36:12,310 --> 00:36:13,710
+كمان كمان كمان كمان كمان كمان كمان كمان كمان كمان
+
+406
+00:36:13,710 --> 00:36:14,690
+كمان كمان كمان كمان كمان كمان كمان كمان كمان كمان
+
+407
+00:36:34,440 --> 00:36:39,660
+yes please thank
+
+408
+00:36:39,660 --> 00:36:44,720
+you very much thank you very much good as soon as
+
+409
+00:36:44,720 --> 00:36:54,180
+he comes they will go out yeah okay
+
+410
+00:36:54,180 --> 00:37:02,140
+after I finish this lecture
+
+411
+00:37:05,760 --> 00:37:15,700
+Okay I will leave this room right؟ Okay now we
+
+412
+00:37:15,700 --> 00:37:22,220
+have two clauses where is the time clause?عندما
+
+413
+00:37:22,220 --> 00:37:27,660
+أنتهي و أرحل، هذا هو الكلمة الرئيسية، أريد من شخص
+
+414
+00:37:27,660 --> 00:37:32,880
+ما أن يأتي هنا و يكتب و يكمل هذه الكلمة، سأ ..
+
+415
+00:37:32,880 --> 00:37:36,800
+حسنًا، من يستطيع أن يأتي و يكتمل؟ نعم، أرجوك،
+
+416
+00:37:36,800 --> 00:37:39,020
+تعال، لا، لا، أريدك أن تكتب
+
+417
+00:37:57,850 --> 00:38:09,810
+go on go on leave here okay
+
+418
+00:38:09,810 --> 00:38:13,070
+thank you very much thank you now what do you
+
+419
+00:38:13,070 --> 00:38:14,870
+think of this sentence يا
+
+420
+00:38:18,860 --> 00:38:24,080
+بسيطة، لا نستخدم كومة، لا نستخدم كومة عندما نبدأ
+
+421
+00:38:24,080 --> 00:38:30,120
+بالقصة الرئيسية، انت تستخدم كومة فقط إذا بدأت
+
+422
+00:38:30,120 --> 00:38:34,700
+بالقصة الرئيسية، بعد القصة الرئيسية، هناك كومة،
+
+423
+00:38:34,700 --> 00:38:38,720
+لكن إذا بدأت بالقصة الأخرى، القصة الرئيسية، لا
+
+424
+00:38:38,720 --> 00:38:42,880
+تستخدم كومة، الأن هذه كلمة جيدة، شكرا جزيلا، هذه
+
+425
+00:38:42,880 --> 00:38:47,300
+كلمة جيدة، لا تستخدم كومة إذا بدأت بالقصة الرئيسية
+
+426
+00:39:03,350 --> 00:39:09,410
+الان كما قلنا ان قصة الوقت تبدأ أو تبدأ مع كلمات
+
+427
+00:39:09,410 --> 00:39:14,270
+مثل وين، قبل، بعد، وانت تعلمين انهم يوضحون الوقت
+
+428
+00:39:14,270 --> 00:39:20,550
+أو يظهرون الوقت القصة الوقتية يمكن استخدامها في
+
+429
+00:39:20,550 --> 00:39:28,670
+البداية للمصطلح أو في الجزء الثاني من المصطلحمثل
+
+430
+00:39:28,670 --> 00:39:34,530
+ما قلنا إذا بدأت بخطة الوقت، إستخدمي كمة وإذا بدأت
+
+431
+00:39:34,530 --> 00:39:40,830
+بخطة الوضع وخطة الأخرى، لا تستخدمي كمة. لا تستخدمي
+
+432
+00:39:40,830 --> 00:39:41,470
+كمة. حسنا.
+
+433
+00:39:47,730 --> 00:39:56,970
+الآن عندما أقول بينما أسرع في المنزلI'm going to
+
+434
+00:39:56,970 --> 00:40:02,330
+listen to the news while I'm driving home I'm
+
+435
+00:40:02,330 --> 00:40:07,230
+going to listen to the news while I'm driving
+
+436
+00:40:07,230 --> 00:40:13,990
+while I'm driving which tense is used present
+
+437
+00:40:13,990 --> 00:40:17,810
+progressive good what does it indicate what does
+
+438
+00:40:17,810 --> 00:40:26,570
+it showماذا أقصد؟ مستقبل؟ حسنًا شكرا جزيلا. الآن
+
+439
+00:40:26,570 --> 00:40:31,750
+عندما أستخدم الـ progressive في المصطلح الوقت،
+
+440
+00:40:31,750 --> 00:40:33,430
+ماذا تفهم؟
+
+441
+00:40:42,690 --> 00:40:47,090
+العمل سيكون في اتجاه اتجاه اتجاه اتجاه اتجاه اتجاه
+
+442
+00:40:47,090 --> 00:40:48,930
+اتجاه اتجاه اتجاه اتجاه اتجاه اتجاه اتجاه اتجاه
+
+443
+00:40:48,930 --> 00:40:51,910
+اتجاه اتجاه اتجاه اتجاه
+
+444
+00:40:53,950 --> 00:40:59,530
+I'm going to have some tea. Okay. So you can use
+
+445
+00:40:59,530 --> 00:41:02,170
+the progressive to indicate that the action is
+
+446
+00:41:02,170 --> 00:41:07,030
+what will be going on will be in a progress in a
+
+447
+00:41:07,030 --> 00:41:09,610
+certain time in the future
+
+448
+00:41:12,620 --> 00:41:16,660
+الأن، انظر إلى السلسلة الأخرى، سأذهب للعبور بعد أن
+
+449
+00:41:16,660 --> 00:41:23,640
+أنتهي عملي، سأذهب للعبور بعد أن أنتهي عملي، بعد أن
+
+450
+00:41:23,640 --> 00:41:30,220
+أنتهي، بعد أن أنتهييمكنك استخدام السمبل ويمكنك
+
+451
+00:41:30,220 --> 00:41:35,380
+استخدام الـ perfect. لكن ماذا تفكر؟ أي إشارة؟ ما
+
+452
+00:41:35,380 --> 00:41:38,140
+هي الرسالة التي تريد أن ترسلها للقراءة أو
+
+453
+00:41:38,140 --> 00:41:46,360
+للمستمعين عندما تقول بعد أن انتهيت؟ الرسالة هي أن
+
+454
+00:41:46,360 --> 00:41:50,100
+الأفعال انتهيت وكملتها. جيد جدا شكرا جزيلا
+
+455
+00:41:55,980 --> 00:42:03,080
+أمك تطلب منك أن تفعل شيئ ما، ماذا تقول؟ سأفعله،
+
+456
+00:42:03,080 --> 00:42:10,640
+سأنهي المنزل بعد أن أنتهي العمل في المنزل أو بعد
+
+457
+00:42:10,640 --> 00:42:13,080
+أن أنتهي العمل في المنزل، إذا كنت تريد أن تتأكد
+
+458
+00:42:13,080 --> 00:42:21,760
+هنا، لتأكد أنك ستفعلها بعد أن أنتهي العمل في
+
+459
+00:42:21,760 --> 00:42:28,290
+المنزلبعد ذلك يمكننا استخدام الـ perfect لإنهاء
+
+460
+00:42:28,290 --> 00:42:34,710
+الاختصار او لإنهاء الاختصار
+
+461
+00:42:46,080 --> 00:42:51,660
+دعنا نوقف و نعمل نصيحة عن ما كان لدينا اليوم، ماذا
+
+462
+00:42:51,660 --> 00:42:55,340
+فعلنا؟ هل يمكنك أن تغلق الجزء؟ هل يمكنك أن تغلق
+
+463
+00:42:55,340 --> 00:43:00,200
+الجزء؟ افتح عقلك و أخبرني ماذا حدثنا اليوم؟ نعم،
+
+464
+00:43:00,200 --> 00:43:04,700
+أعمل نصيحة قصيرة، ماذا فهمت من هذه الدراسة؟ نعم،
+
+465
+00:43:04,700 --> 00:43:09,140
+نعم،
+
+466
+00:43:09,140 --> 00:43:10,360
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+467
+00:43:10,360 --> 00:43:10,440
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+468
+00:43:10,440 --> 00:43:10,600
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+469
+00:43:10,600 --> 00:43:11,600
+نعم، نعم، نعم، نعم، نعم، نعم، ن
+
+470
+00:43:15,490 --> 00:43:18,630
+Okay if there is no pre planning you decide now
+
+471
+00:43:18,630 --> 00:43:21,550
+you use well thank you very much good yes please
+
+472
+00:43:21,550 --> 00:43:26,290
+very
+
+473
+00:43:26,290 --> 00:43:31,770
+good so they can you are they are used for
+
+474
+00:43:31,770 --> 00:43:35,250
+prediction express future time thank you احلام
+
+475
+00:43:38,590 --> 00:43:44,790
+we use again thank you very much we use want to
+
+476
+00:43:44,790 --> 00:43:48,610
+express what refusal okay you are not accepting
+
+477
+00:43:48,610 --> 00:43:56,070
+yes please for
+
+478
+00:43:56,070 --> 00:44:01,150
+pre planning okay for pre planning she's she's
+
+479
+00:44:01,150 --> 00:44:05,950
+going to buy a cakeهل تعرفين لماذا أصدقاءها
+
+480
+00:44:05,950 --> 00:44:12,110
+يزورونها الليلة؟ نعم شكرا، نعم أرجوك نحن نستخدم
+
+481
+00:44:12,110 --> 00:44:17,050
+الوثيقة للتحول للحديث لكننا نستخدم التعريف الوثيق
+
+482
+00:44:17,050 --> 00:44:23,570
+أو الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة
+
+483
+00:44:23,570 --> 00:44:28,090
+الوثيقة
+
+484
+00:44:28,090 --> 00:44:31,390
+الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة
+
+485
+00:44:31,390 --> 00:44:32,030
+الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة
+
+486
+00:44:32,030 --> 00:44:34,140
+الوثيقة الوثيقة الوثيقة الوثيقة الوثيقة الوثممتاز،
+
+487
+00:44:34,140 --> 00:44:48,540
+شكرا، نقطة جيدة، نعم؟ نقطتك، جيد، نعم؟ شكرا،
+
+488
+00:44:48,540 --> 00:44:53,600
+جيد، لذا إذا بدأت بخطة وقت، حسنا، يجب أن يتبع
+
+489
+00:44:53,600 --> 00:44:59,640
+بخطة، لكن إذا بدأت بخطة الرئيسية، حسنا، لا تكتب
+
+490
+00:44:59,640 --> 00:45:01,280
+خطة بعدها، نعم؟
+
+491
+00:45:08,490 --> 00:45:14,090
+when we use present progressive in a time clause
+
+492
+00:45:14,090 --> 00:45:20,310
+we show an activity will be in progress in the
+
+493
+00:45:20,310 --> 00:45:24,730
+future in time clauses we use present symbol to
+
+494
+00:45:24,730 --> 00:45:30,450
+show a future but we don't use the future we use
+
+495
+00:45:30,450 --> 00:45:32,930
+the present symbol to express the future
+
+496
+00:45:37,070 --> 00:45:40,410
+Thank you very much thank you very much yes please
+
+497
+00:45:40,410 --> 00:45:44,530
+good
+
+498
+00:45:44,530 --> 00:45:49,830
+thank you yeah thank
+
+499
+00:45:49,830 --> 00:45:51,890
+you very much do you want to ask me about any
+
+500
+00:45:51,890 --> 00:45:55,710
+point in today's lecture any question okay thank
+
+501
+00:45:55,710 --> 00:45:56,330
+you very much
+
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/RMnY5pPpBHo_raw.json b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/RMnY5pPpBHo_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..7e9226a784d2050eba6327f8e50e89fdbbf9c9d8
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/RMnY5pPpBHo_raw.json
@@ -0,0 +1 @@
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Who can explain this point? What does that mean? We talked about this just minutes before. Who can explain this point? 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عندما أستخدم الـ progressive في المصطلح الوقت، ماذا تفهم؟", "tokens": [2304, 45636, 995, 5551, 4587, 9381, 3215, 22807, 3714, 14851, 4587, 36150, 22807, 11331, 3794, 1863, 14111, 995, 13412, 4117, 23557, 10874, 11622, 1829, 15040, 13, 6024, 48506, 43242, 15042, 5551, 14851, 9778, 40448, 2423, 39184, 16131, 8978, 9673, 9381, 9566, 1211, 5016, 2423, 30543, 2655, 12399, 3714, 45636, 995, 6055, 5172, 16095, 22807], "avg_logprob": -0.5005682034925981, "compression_ratio": 1.2666666666666666, "no_speech_prob": 0.0, "words": [{"start": 2419.83, "end": 2421.23, "word": "ماذا", "probability": 0.5166422526041666}, {"start": 2421.23, "end": 2422.25, "word": " أقصد؟", "probability": 0.588916015625}, {"start": 2422.25, "end": 2424.49, "word": " مستقبل؟", "probability": 0.5994140625}, {"start": 2424.49, "end": 2424.77, "word": " حسنًا", "probability": 0.70654296875}, {"start": 2424.77, "end": 2425.17, "word": " شكرا", "probability": 0.75}, {"start": 2425.17, "end": 2425.45, "word": " جزيلا.", 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\ No newline at end of file
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/V2qljKhRolo_postprocess.srt b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/V2qljKhRolo_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..4b0e9d6c9a01322de7d5b9a132df6ba0bc34f60e
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/V2qljKhRolo_postprocess.srt
@@ -0,0 +1,1516 @@
+1
+00:00:22,700 --> 00:00:29,060
+سلام عليكم كيف حالك اليوم؟ انا بخير كيف حالك
+
+2
+00:00:29,060 --> 00:00:31,460
+اليوم؟ انا بخير كيف حالك اليوم؟ انا بخير كيف حالك
+
+3
+00:00:31,460 --> 00:00:31,700
+اليوم؟ انا بخير كيف حالك اليوم؟ انا بخير كيف حالك
+
+4
+00:00:31,700 --> 00:00:32,080
+اليوم؟ انا بخير كيف حالك اليوم؟ انا بخير كيف حالك
+
+5
+00:00:32,080 --> 00:00:32,420
+اليوم؟ انا بخير كيف حالك اليوم؟ انا بخير كيف حالك
+
+6
+00:00:32,420 --> 00:00:32,840
+اليوم؟ انا بخير كيف حالك اليوم؟ انا بخير كيف حالك
+
+7
+00:00:32,840 --> 00:00:33,880
+اليوم؟ انا بخير كيف حالك اليوم؟ انا بخير كيف حالك
+
+8
+00:00:33,880 --> 00:00:38,960
+اليوم؟ انا بخير كيف حالك اليوم؟ انا بخير كيف حالك
+
+9
+00:00:38,960 --> 00:00:43,400
+اليوم؟ انا بخير كيف حالك اليوم؟ انا بخ
+
+10
+00:00:49,040 --> 00:00:52,620
+it is a noun what type of noun what did we call it
+
+11
+00:00:52,620 --> 00:00:56,500
+yeah very good it is a collective noun thank you
+
+12
+00:00:56,500 --> 00:00:59,670
+can you give me another collective nounيه team
+
+13
+00:00:59,670 --> 00:01:02,450
+team very good that's right another collective
+
+14
+00:01:02,450 --> 00:01:05,370
+noun yeah thank you very much that's right so they
+
+15
+00:01:05,370 --> 00:01:09,190
+are collective nouns you know a collective noun it
+
+16
+00:01:09,190 --> 00:01:14,050
+is one word but includes a lot of persons yeah
+
+17
+00:01:14,050 --> 00:01:19,130
+members how shall we use it grammatically shall I
+
+18
+00:01:19,130 --> 00:01:25,120
+saythey singular plural okay if you look at the
+
+19
+00:01:25,120 --> 00:01:27,380
+first sentence would you read the first sentence
+
+20
+00:01:27,380 --> 00:01:30,800
+please my family is large it is composed of nine
+
+21
+00:01:30,800 --> 00:01:37,380
+members my family is large it is composed of it is
+
+22
+00:01:37,380 --> 00:01:43,460
+the family is composed now I'm talking about the
+
+23
+00:01:43,460 --> 00:01:48,520
+family as one unit okay as one unit now what's
+
+24
+00:01:48,520 --> 00:01:53,240
+your family nameأبو ريالة جيد ما هو إسم عائلتك؟
+
+25
+00:01:53,240 --> 00:01:59,940
+شهادة شهادة و أبو ريالة هما عائلتين مختلفة أعني
+
+26
+00:01:59,940 --> 00:02:05,000
+العائلة كمجلة واحدة أنا لا أتكلم عن أشخاص أو عائلة
+
+27
+00:02:05,000 --> 00:02:13,460
+كمجلة في هذه الحالة عندما أتكلم عن كلمة مجلة كمجلة
+
+28
+00:02:13,460 --> 00:02:21,360
+أقول إنها مجلسة منهو مصطلح من لكن انظر إلى السلسلة
+
+29
+00:02:21,360 --> 00:02:27,900
+الأخرى عائلتي محبوبة ومدعومة عائلتي محبوبة ومدعومة
+
+30
+00:02:27,900 --> 00:02:32,380
+عندما أتكلم عن الحب في العائلة على سبيل المثال
+
+31
+00:02:32,380 --> 00:02:38,240
+والأب يحب أمي وانها يحبه يحبوننا ونحن نحبهم أنا
+
+32
+00:02:38,240 --> 00:02:43,140
+أحب أخواتي وأخواتي يحبوني أخواتي يحبون بعضهم البعض
+
+33
+00:02:43,140 --> 00:02:50,160
+وكذلك فأنا أتكلم عنهذا صحيح، إنها تتعرف على أشخاص
+
+34
+00:02:50,160 --> 00:02:55,500
+من العائلة، أنا أتكلم عن أشخاص، لذلك في المثال
+
+35
+00:02:55,500 --> 00:03:03,160
+الأول، أتكلم عن العائلة كمجلة غير شخصية، لم أقصد
+
+36
+00:03:03,160 --> 00:03:07,580
+الناس، الناس في العائلة، لذلك أقولها، ولكن عندما
+
+37
+00:03:07,580 --> 00:03:13,250
+أقصد العائلات، الناس، الانسانين من العائلةالعائلة
+
+38
+00:03:13,250 --> 00:03:17,630
+على سبيل المثال انا يجب ان استخدم what؟ they انظر
+
+39
+00:03:17,630 --> 00:03:26,910
+الى هذا المثال عائلتي راضية
+
+40
+00:03:26,910 --> 00:03:34,830
+ومدحسة is or are؟ is and are
+
+41
+00:03:37,550 --> 00:03:43,190
+in general in general when I mean the family as
+
+42
+00:03:43,190 --> 00:03:48,050
+one unit I say the family is okay it but when I
+
+43
+00:03:48,050 --> 00:03:52,770
+mean the members I mean what are but there is a
+
+44
+00:03:52,770 --> 00:03:55,210
+slight difference in British English between
+
+45
+00:03:55,210 --> 00:03:58,110
+British English and American English okay
+
+46
+00:04:01,480 --> 00:04:05,040
+in American English they say what؟ the government
+
+47
+00:04:05,040 --> 00:04:08,920
+is .. the government is a collective noun right؟
+
+48
+00:04:08,920 --> 00:04:12,760
+but in Britain they say the government are .. the
+
+49
+00:04:12,760 --> 00:04:18,220
+government are okay؟ in some countries they say ..
+
+50
+00:04:18,220 --> 00:04:19,640
+yes
+
+51
+00:04:23,480 --> 00:04:26,840
+yes in some countries things are different so it
+
+52
+00:04:26,840 --> 00:04:30,880
+depends on the country now here in this generally
+
+53
+00:04:30,880 --> 00:04:36,860
+speaking the Americans say the family it always
+
+54
+00:04:36,860 --> 00:04:41,060
+the government it but in British English the
+
+55
+00:04:41,060 --> 00:04:45,660
+government are and the family are now look these
+
+56
+00:04:45,660 --> 00:04:48,480
+are examples of collective nouns would you read
+
+57
+00:04:48,480 --> 00:04:52,780
+please class crowd audience
+
+58
+00:05:02,800 --> 00:05:10,080
+Thank you Now look at this exerciseread the
+
+59
+00:05:10,080 --> 00:05:15,840
+introduction خديجة look
+
+60
+00:05:15,840 --> 00:05:20,320
+this
+
+61
+00:05:20,320 --> 00:05:23,500
+is very important in some of the sentences there
+
+62
+00:05:23,500 --> 00:05:28,280
+is more than one possibility okay it means you can
+
+63
+00:05:28,280 --> 00:05:31,260
+use the singular and you can use what the plural
+
+64
+00:05:31,260 --> 00:05:34,950
+this is right and this is right go onchoose the
+
+65
+00:05:34,950 --> 00:05:38,290
+correct singular or plural verb in parentheses as
+
+66
+00:05:38,290 --> 00:05:42,330
+necessary thank you now let's start number one I
+
+67
+00:05:42,330 --> 00:05:44,230
+looked up some information about the average
+
+68
+00:05:44,230 --> 00:05:48,450
+American families I found out that it consists of
+
+69
+00:05:48,450 --> 00:05:51,830
+two points each other okay so what shall I write
+
+70
+00:05:51,830 --> 00:05:57,250
+it consists it consists thank you good it consists
+
+71
+00:05:57,250 --> 00:06:02,800
+thank you next one yes pleaseالجمهور يقلبوا
+
+72
+00:06:02,800 --> 00:06:07,200
+الانتسياط .. الانتسياط بشكل صحيح و يستمتعون
+
+73
+00:06:07,200 --> 00:06:12,020
+بالمقابلة اليوم .. اليوم ماذا تفكر؟ اليوم .. لأننا
+
+74
+00:06:12,020 --> 00:06:16,220
+نتكلم عن .. انهم اشخاص .. الان عندما .. عندما
+
+75
+00:06:16,220 --> 00:06:21,360
+يقلبوا، حسنا؟ هل يمكنك أن تقرر من يفعل الاختيار؟
+
+76
+00:06:21,360 --> 00:06:25,480
+هل يمكنني أن أقول؟ من يقلب؟ مها يقلب؟ فاطمة يقلب؟
+
+77
+00:06:25,480 --> 00:06:31,500
+او هم يقلبوا كجزء واحد؟ انا أقصد انهم استمتعواOkay
+
+78
+00:06:31,500 --> 00:06:34,240
+they have enjoyed also and they are they are
+
+79
+00:06:34,240 --> 00:06:40,800
+clapping okay they clapped All
+
+80
+00:06:40,800 --> 00:06:45,300
+of them because you all of them clapped and all of
+
+81
+00:06:45,300 --> 00:06:52,700
+them enjoyed so Yes they had it why they had it as
+
+82
+00:06:52,700 --> 00:07:00,800
+one yes now Now listenعندما أقصد الجمهور عندما
+
+83
+00:07:00,800 --> 00:07:07,800
+أقصد الجمهور أقول they عندما مجتمع يتجاوز بين ات و
+
+84
+00:07:07,800 --> 00:07:15,340
+دي هم يتجاوزون كجمهور واحد او كشخص مختلف واحد
+
+85
+00:07:15,340 --> 00:07:19,980
+جمهور واحد يتجاوز مع بعض، لا أستطيع أن أعرف من
+
+86
+00:07:19,980 --> 00:07:24,590
+يفعل الاختيار، هل هذا واحد او ذلك واحد؟Okay,
+
+87
+00:07:24,590 --> 00:07:27,850
+distinguish. So they are clubbing as if they are
+
+88
+00:07:27,850 --> 00:07:36,970
+one body, okay? As one unit. So we say it. It had
+
+89
+00:07:36,970 --> 00:07:44,090
+number four. Yes please. The crowds at the soccer
+
+90
+00:07:44,090 --> 00:07:49,150
+game was huge. It exceeded hundred thousand
+
+91
+00:07:49,150 --> 00:07:56,890
+people. Now why it?now the crowd were one hundred
+
+92
+00:07:56,890 --> 00:08:01,150
+thousand people one hundred thousand people the
+
+93
+00:08:01,150 --> 00:08:08,190
+crowd okay so one hundred thousand people we say
+
+94
+00:08:08,190 --> 00:08:18,430
+is or are are okay so we say they doctor yesهنا
+
+95
+00:08:18,430 --> 00:08:24,110
+عندما نقول ان عائلتي كبيرة فهي مجتمعة من 9 أعضاء،
+
+96
+00:08:24,110 --> 00:08:32,130
+هذا هو نفس الشيء، هذا هو نفس الشيء، انت قد تكون
+
+97
+00:08:32,130 --> 00:08:39,610
+صحيح، لكن هنا انت تعرفين، لأن هذا صحيح، 100 ألف
+
+98
+00:08:39,610 --> 00:08:44,900
+شخصit is a unit how it is a unit okay it is a unit
+
+99
+00:08:44,900 --> 00:08:51,880
+but okay now the crowd equals one hundred people
+
+100
+00:08:51,880 --> 00:08:59,340
+it is what anyhow we said we said again okay now
+
+101
+00:08:59,340 --> 00:09:03,580
+this is the crowd equals one hundred people so one
+
+102
+00:09:03,580 --> 00:09:08,440
+hundred people are the one hundred people are not
+
+103
+00:09:08,440 --> 00:09:14,450
+isso I think much better to use they next one nine
+
+104
+00:09:14,450 --> 00:09:19,550
+members also are but we say it is composed nine
+
+105
+00:09:19,550 --> 00:09:25,610
+which one this example my family is large this
+
+106
+00:09:25,610 --> 00:09:29,950
+sentence and this are the same in the previous
+
+107
+00:09:29,950 --> 00:09:34,510
+example in the previous example so it is possible
+
+108
+00:09:34,510 --> 00:09:39,030
+that you use it okay yeah
+
+109
+00:09:50,250 --> 00:09:56,690
+I think there is a full stop here okay I think
+
+110
+00:09:56,690 --> 00:10:02,930
+there is a full stop so we say what they thank you
+
+111
+00:10:02,930 --> 00:10:03,890
+they
+
+112
+00:10:12,290 --> 00:10:19,010
+next one yes please it
+
+113
+00:10:19,010 --> 00:10:22,670
+was
+
+114
+00:10:22,670 --> 00:10:31,530
+larger than thank you next
+
+115
+00:10:31,530 --> 00:10:38,970
+one next one yes pleasethe class is planning a
+
+116
+00:10:38,970 --> 00:10:42,770
+party for the last day in school they are going to
+
+117
+00:10:42,770 --> 00:10:45,290
+bring many different kinds of food and invite some
+
+118
+00:10:45,290 --> 00:10:49,470
+of their friends to celebrate with the class so
+
+119
+00:10:49,470 --> 00:10:56,590
+they are good they are yeah invite some of their
+
+120
+00:10:56,590 --> 00:11:03,070
+friends to invite with them thank you and finally
+
+121
+00:11:03,070 --> 00:11:08,420
+finally yesthe class is too small it is going to
+
+122
+00:11:08,420 --> 00:11:13,580
+be cancelled it is going thank you it is going to
+
+123
+00:11:13,580 --> 00:11:23,440
+be cancelled check
+
+124
+00:11:23,440 --> 00:11:25,240
+your answers again
+
+125
+00:11:40,310 --> 00:11:45,430
+reflexive pronouns would you read please the
+
+126
+00:11:45,430 --> 00:11:57,790
+reflexive pronouns thank
+
+127
+00:11:57,790 --> 00:12:04,870
+you good before starting talking about reflexive
+
+128
+00:12:04,870 --> 00:12:11,250
+pronounsthere is a very big mistake most of the
+
+129
+00:12:11,250 --> 00:12:18,270
+students okay commit you know we say our selves
+
+130
+00:12:18,270 --> 00:12:24,270
+some people write our self be careful this is not
+
+131
+00:12:24,270 --> 00:12:31,730
+English okay and them themselves
+
+132
+00:12:31,730 --> 00:12:37,050
+also this is not usedplease be careful if you want
+
+133
+00:12:37,050 --> 00:12:40,450
+to use self this is singular use it with a
+
+134
+00:12:40,450 --> 00:12:46,430
+singular pronoun my your him it one okay if you
+
+135
+00:12:46,430 --> 00:12:50,630
+want to use selves use it with plural pronouns
+
+136
+00:12:50,630 --> 00:12:56,210
+your sorry our your and themselves
+
+137
+00:13:03,690 --> 00:13:06,090
+look at the first sentence would you read the
+
+138
+00:13:06,090 --> 00:13:10,090
+sentence Larry was in the theater I saw him I
+
+139
+00:13:10,090 --> 00:13:15,910
+talked to him thank you now I saw him what type of
+
+140
+00:13:15,910 --> 00:13:21,350
+pronoun is him it is an object pronoun very good
+
+141
+00:13:21,350 --> 00:13:23,850
+it is an object pronoun if you look at this
+
+142
+00:13:23,850 --> 00:13:29,310
+sentence Larry was in the theater I saw him him
+
+143
+00:13:29,310 --> 00:13:34,620
+this is what object of the themthis is object of
+
+144
+00:13:34,620 --> 00:13:39,220
+the verb now what about the other one him it is
+
+145
+00:13:39,220 --> 00:13:45,320
+object of the preposition thank you now the object
+
+146
+00:13:45,320 --> 00:13:52,220
+a pronoun is usually used as what as the object of
+
+147
+00:13:52,220 --> 00:13:55,880
+the verb or the object of the preposition thank
+
+148
+00:13:55,880 --> 00:13:59,460
+you look at this sentence I saw myself in the
+
+149
+00:13:59,460 --> 00:14:05,630
+mirrorWhere is the subject? I. Good. Where is the
+
+150
+00:14:05,630 --> 00:14:09,910
+object? Myself. Good. By the way, the object is
+
+151
+00:14:09,910 --> 00:14:15,710
+usually an answer to what؟ An answer to what؟ Now,
+
+152
+00:14:15,790 --> 00:14:21,010
+I read a story. What did I read? A story. أه, I
+
+153
+00:14:21,010 --> 00:14:26,370
+saw the object. What did I say?الوضع، نعم رأيت
+
+154
+00:14:26,370 --> 00:14:32,910
+صديقتي، ماذا رأيت؟ أكلت أبل، ماذا أكلت؟ وكذلك مرة
+
+155
+00:14:32,910 --> 00:14:39,450
+أخرى، عادةً الوضع هو إجابة لما؟ رأيت ماذا؟ نفسي،
+
+156
+00:14:39,450 --> 00:14:46,650
+رأيت نفسي الآن نفسي ماذا؟ وضع الفعل، جيد جدًا، هو
+
+157
+00:14:46,650 --> 00:14:56,460
+وضع الفعل، صحيح؟ الآن أنا و نفسيهل هم نفس الناس؟
+
+158
+00:14:56,460 --> 00:15:02,420
+نعم. الآن عندما أقول على سبيل المثال هودا رأى
+
+159
+00:15:02,420 --> 00:15:10,940
+نفسها في المظلمة، هودا ونفسها هي نفس الناس. الآن
+
+160
+00:15:10,940 --> 00:15:16,720
+انظر للعلم الأخر، رأيت نفسي لوقت طويلI where is
+
+161
+00:15:16,720 --> 00:15:21,220
+the subject؟ the object؟ okay now this is an
+
+162
+00:15:21,220 --> 00:15:24,520
+object of the verb what type of object is this?
+
+163
+00:15:25,280 --> 00:15:28,120
+object of the preposition
+
+164
+00:15:33,570 --> 00:15:38,990
+الوضع و الوضع في التجارب هي ماذا؟ هي نفسها، هم نفس
+
+165
+00:15:38,990 --> 00:15:45,790
+الناس، أنا أتكلم عن نفس الناس، كانت تنظر إلى نفسها
+
+166
+00:15:45,790 --> 00:15:51,950
+في المظلمة، الآن في هذه اللحظة رأيت نفسي في
+
+167
+00:15:51,950 --> 00:15:55,710
+المظلمة، هل يمكنني أن أقول رأيت نفسي في المظلمة؟
+
+168
+00:15:55,710 --> 00:16:00,170
+لا، لذلك يجب أن أستخدم نفسي
+
+169
+00:16:02,740 --> 00:16:09,200
+إذا كانت الوضع و الوضع نفسه، يجب أن نستخدم وفق،
+
+170
+00:16:09,200 --> 00:16:13,580
+نستخدم نفسنا و نستخدم نفسنا و نستخدم نفسنا و
+
+171
+00:16:13,580 --> 00:16:14,300
+نستخدم نفسنا و نستخدم نفسنا و نستخدم نفسنا و
+
+172
+00:16:14,300 --> 00:16:14,940
+نستخدم نفسنا و نستخدم نفسنا و نستخدم نفسنا و
+
+173
+00:16:14,940 --> 00:16:15,160
+نستخدم نفسنا و نستخدم نفسنا و نستخدم نفسنا و
+
+174
+00:16:15,160 --> 00:16:16,400
+نستخدم نفسنا و نستخدم نفسنا و نستخدم نفسنا و
+
+175
+00:16:16,400 --> 00:16:17,760
+نستخدم نفسنا و نستخدم نفسنا و نستخدم نفسنا و
+
+176
+00:16:17,760 --> 00:16:31,900
+نستخدم نفسنا و نستخدم نفسنا و نستخدم نفسنا و
+
+177
+00:16:31,900 --> 00:16:43,910
+نستخهو ماذا؟ هو موضوع الاسم. أين الموضوع؟ هم نفس
+
+178
+00:16:43,910 --> 00:16:52,830
+الناس؟ نعم هم نفس الناس. الأن نقول هدا أخذه أبوها.
+
+179
+00:16:56,030 --> 00:17:02,730
+الان الموضوع و الموضوع من المقالة هي نفس الشخص في
+
+180
+00:17:02,730 --> 00:17:06,390
+السطح الأول انت تعرفين ان هذا موضوع من المقالة
+
+181
+00:17:06,390 --> 00:17:12,690
+عندما الموضوع و الموضوع من المقالة هي نفس الشخص
+
+182
+00:17:12,690 --> 00:17:18,790
+نستخدم نفس البرنامج في السطح الأخر نستخدم ماذا؟
+
+183
+00:17:18,790 --> 00:17:30,060
+موضوع برنامج فماذا تفهم؟ ماذا تفهم؟إذا موضوع الفعل
+
+184
+00:17:30,060 --> 00:17:36,700
+و الموضوع نفس الشخص نحن .. نحن لا نستطيع استخدام
+
+185
+00:17:36,700 --> 00:17:44,780
+.. نحن يجب أن نستخدم نموذج لكن إذا موضوع الفعل و
+
+186
+00:17:44,780 --> 00:17:49,020
+الموضوع نفس الشخص نستطيع استخدام .. نستطيع استخدام
+
+187
+00:17:49,020 --> 00:17:55,300
+.. جيد جدا نستطيع استخدام نموذج أو نموذج، هل هذا
+
+188
+00:17:55,300 --> 00:17:56,040
+صحيح؟
+
+189
+00:17:59,140 --> 00:18:04,000
+object of the verb you must use object of the
+
+190
+00:18:04,000 --> 00:18:09,140
+preposition you can use okay you can use an object
+
+191
+00:18:09,140 --> 00:18:11,960
+pronoun or you can use a subject pronoun any
+
+192
+00:18:11,960 --> 00:18:13,320
+question on this point
+
+193
+00:18:23,390 --> 00:18:32,550
+Now look at this page read this example with me
+
+194
+00:18:32,550 --> 00:18:37,030
+this is what object of the preposition you know we
+
+195
+00:18:37,030 --> 00:18:40,190
+did not use a reflexive pronoun good thank you the
+
+196
+00:18:40,190 --> 00:18:45,790
+other one read itwith him again object to pronoun
+
+197
+00:18:45,790 --> 00:18:50,490
+object of the preposition sorry we did not use a
+
+198
+00:18:50,490 --> 00:18:54,350
+reflexive pronoun again please yeah read the other
+
+199
+00:18:54,350 --> 00:19:01,630
+one I looked around me thank you again object of
+
+200
+00:19:01,630 --> 00:19:03,650
+the preposition next one
+
+201
+00:19:06,350 --> 00:19:10,810
+شكرا جزيلا لك. كانت تبقى أبنها قريبا من موضوع الـ
+
+202
+00:19:10,810 --> 00:19:17,610
+preposition. حسنا؟ الآن، انظر إلى هذا.
+
+203
+00:19:20,350 --> 00:19:22,030
+انظر إلى هذا المثال.
+
+204
+00:19:27,210 --> 00:19:36,200
+دعني أعطيك مثال. من وضعت هذه القرصة هنا؟I myself
+
+205
+00:19:36,200 --> 00:19:50,320
+put it very good I myself put it okay I myself put
+
+206
+00:19:50,320 --> 00:19:59,160
+it good I myself put it I myself you didn't put it
+
+207
+00:19:59,160 --> 00:20:06,900
+هنا ده no I myself put itit is used for what?
+
+208
+00:20:07,600 --> 00:20:11,400
+emphasize or emphatic very good she wants to
+
+209
+00:20:11,400 --> 00:20:17,080
+emphasize okay she wants to emphasize now also can
+
+210
+00:20:17,080 --> 00:20:19,760
+I say I put it myself
+
+211
+00:20:23,390 --> 00:20:28,650
+Okay so we can use to emphasize the action you can
+
+212
+00:20:28,650 --> 00:20:31,670
+use the reflexive pronoun immediately after the
+
+213
+00:20:31,670 --> 00:20:36,170
+subject or at the end of the sentence or at the
+
+214
+00:20:36,170 --> 00:20:41,930
+end of the sentence Khadija is living with her
+
+215
+00:20:41,930 --> 00:20:45,770
+family you are living with the family right now
+
+216
+00:20:45,770 --> 00:20:52,130
+she is not living by herself okay she is not
+
+217
+00:20:52,130 --> 00:20:52,650
+living
+
+218
+00:21:00,010 --> 00:21:04,570
+by herself what do you understand by herself yeah
+
+219
+00:21:04,570 --> 00:21:09,330
+very good she is not living alone okay are you
+
+220
+00:21:09,330 --> 00:21:14,010
+living by yourself yes i'm living with my family
+
+221
+00:21:14,010 --> 00:21:19,070
+are you living by yourself very good so i'm also
+
+222
+00:21:19,070 --> 00:21:22,710
+not living by myself i'm living with the with my
+
+223
+00:21:22,710 --> 00:21:23,910
+family now
+
+224
+00:21:32,490 --> 00:21:35,410
+look at the examples yeah who wants to read the
+
+225
+00:21:35,410 --> 00:21:40,830
+dialogue i want two students did someone email the
+
+226
+00:21:40,830 --> 00:21:45,550
+report to mr lee yes are you sure yes i myself
+
+227
+00:21:45,550 --> 00:21:46,950
+emailed the report to him
+
+228
+00:21:50,060 --> 00:21:55,240
+thank you you know I myself emailed okay to
+
+229
+00:21:55,240 --> 00:22:00,840
+emphasize the action or I emailed myself I emailed
+
+230
+00:22:00,840 --> 00:22:04,140
+myself this sentence when I say Anna lives by
+
+231
+00:22:04,140 --> 00:22:08,920
+herself it means that she's living okay thank you
+
+232
+00:22:08,920 --> 00:22:15,180
+she's living alone look at the examples number one
+
+233
+00:22:15,180 --> 00:22:20,680
+number one yeahI'd like you to come here to do the
+
+234
+00:22:20,680 --> 00:22:27,060
+exercise go on yes please come number
+
+235
+00:22:27,060 --> 00:22:38,680
+two come please yes come you too you too come okay
+
+236
+00:22:38,680 --> 00:22:42,500
+speak while you are writing talk aloud please what
+
+237
+00:22:42,500 --> 00:22:45,040
+did you write what did you write
+
+238
+00:22:48,050 --> 00:22:57,930
+ممتاز، من نفسها، شكرا، اذهب، اتكلم بينما تكتب من
+
+239
+00:22:57,930 --> 00:23:02,050
+نفسها، شكرا، اتكلم من نفسها، شكرا، اتكلم من نفسها،
+
+240
+00:23:02,050 --> 00:23:07,970
+شكرا، اتكلم من نفسها، شكرا، اتكلم من نفسها، شكرا،
+
+241
+00:23:17,380 --> 00:23:26,220
+we draw a picture of ourselves good thank you of
+
+242
+00:23:26,220 --> 00:23:37,560
+yourself thank you yes come pictures
+
+243
+00:23:37,560 --> 00:23:40,840
+of
+
+244
+00:23:40,840 --> 00:23:42,680
+yourselves thank you good
+
+245
+00:23:51,290 --> 00:23:56,470
+عندما يرسم صورة من نفس واحدة ، فهي نفس عظيمة من
+
+246
+00:23:56,470 --> 00:24:03,450
+الألم من نفس واحدة من نفس واحدة من نفس واحدة من
+
+247
+00:24:03,450 --> 00:24:04,370
+نفس واحدة من نفس واحدة من نفس واحدة من نفس واحدة
+
+248
+00:24:04,370 --> 00:24:04,850
+واحدة من نفس واحدة من نفس واحدة من نفس واحدة من
+
+249
+00:24:04,850 --> 00:24:06,530
+نفس واحدة من نفس واحدة من نفس واحدة من نفس واحدة
+
+250
+00:24:06,530 --> 00:24:07,370
+من نفس واحدة من نفس واحدة من نفس واحدة من نفس
+
+251
+00:24:07,370 --> 00:24:07,390
+نفس واحدة من نفس واحدة من نفس واحدة من نفس واحدة
+
+252
+00:24:07,390 --> 00:24:17,290
+من نفس واحدة من نفس واحدة من نفس واحدة من نفس وا
+
+253
+00:24:18,420 --> 00:24:21,840
+and maybe himself yeah and maybe himself good when
+
+254
+00:24:21,840 --> 00:24:25,160
+i'm talking about علي for example himself thank
+
+255
+00:24:25,160 --> 00:24:33,140
+you yeah next
+
+256
+00:24:33,140 --> 00:24:37,520
+exercise come please
+
+257
+00:24:37,520 --> 00:24:41,460
+clean
+
+258
+00:24:41,460 --> 00:24:42,820
+clean then right
+
+259
+00:24:59,560 --> 00:25:05,220
+Thank you. Come.
+
+260
+00:25:08,880 --> 00:25:09,200
+Good
+
+261
+00:25:23,240 --> 00:25:29,100
+ماذا تقول في الكردو جيغنسي كردو ايه اصلا لا اصلا
+
+262
+00:25:29,100 --> 00:25:41,340
+اصلا اصلا اصلا اصلا اصلا اصلا اصلا
+
+263
+00:25:51,280 --> 00:25:54,960
+should I make it in or one that I can make it that
+
+264
+00:25:54,960 --> 00:25:58,620
+it's very hard for me
+
+265
+00:26:09,360 --> 00:26:11,880
+Okay just a minute you are addressing .. you are
+
+266
+00:26:11,880 --> 00:26:17,920
+addressing Anne okay and you .. you look you are
+
+267
+00:26:17,920 --> 00:26:21,300
+addressing her you are talking to her so what do
+
+268
+00:26:21,300 --> 00:26:31,700
+you think yourself good you yourself Yes
+
+269
+00:26:31,700 --> 00:26:32,480
+come please
+
+270
+00:26:43,440 --> 00:26:45,260
+تنظيف و تنظيف و تنظيف و تنظيف و تنظيف و تنظيف و
+
+271
+00:26:45,260 --> 00:26:55,780
+تنظيف و تنظيف و تنظيف و تنظيف و تنظيف و تنظيف و
+
+272
+00:26:55,780 --> 00:26:57,220
+تنظيف و تنظيف و تنظيف و تنظيف و تنظيف و تنظيف و
+
+273
+00:26:57,220 --> 00:26:58,180
+تنظيف و تنظيف و تنظيف
+
+274
+00:27:07,170 --> 00:27:17,850
+نفسك ، جيد ، نفسك التالة تريد
+
+275
+00:27:17,850 --> 00:27:21,670
+أن تسأل؟ لا ، نين نين ، حسناً ، نين لك ، انتظر ،
+
+276
+00:27:21,670 --> 00:27:29,570
+دعها تفعلها انا .. انا اكره مجرمي و انا احب مجرمي
+
+277
+00:27:29,570 --> 00:27:35,530
+لإنساني و انا احب العمل مع نفسيOkay thank you work
+
+278
+00:27:35,530 --> 00:27:39,430
+for myself too good now what does it mean work for
+
+279
+00:27:39,430 --> 00:27:46,770
+myself my own business okay good you want to ask
+
+280
+00:27:46,770 --> 00:27:54,370
+okay what did she write myself your no what about
+
+281
+00:27:54,370 --> 00:27:58,590
+number seven yourselves okay selves you are
+
+282
+00:27:58,590 --> 00:28:01,470
+talking to two people yourselves
+
+283
+00:28:14,930 --> 00:28:31,610
+Go on, go on, don't worry جيد؟
+
+284
+00:28:32,860 --> 00:28:42,740
+I take care of myself and my father and I are
+
+285
+00:28:42,740 --> 00:28:47,160
+healthy because we take good care of ourselves and
+
+286
+00:28:47,160 --> 00:28:50,880
+the
+
+287
+00:28:50,880 --> 00:28:56,260
+people who take care of themselves
+
+288
+00:28:56,260 --> 00:28:59,600
+thank
+
+289
+00:28:59,600 --> 00:29:12,870
+youcheck your answers
+
+290
+00:29:12,870 --> 00:29:26,830
+exercise
+
+291
+00:29:26,830 --> 00:29:30,830
+nineteen homework do it at home
+
+292
+00:29:34,610 --> 00:29:41,850
+now let's come to this exercise choose
+
+293
+00:29:41,850 --> 00:29:48,710
+the correct words in italics number one number one
+
+294
+00:29:48,710 --> 00:29:53,750
+yes come please come here
+
+295
+00:29:53,750 --> 00:30:00,130
+penguins
+
+296
+00:30:00,130 --> 00:30:08,600
+or penguinبنجونات اه حسنًا كلمة عضوية تحتاج إلى
+
+297
+00:30:08,600 --> 00:30:16,040
+ماذا؟ كلمة عضوية الآن اذهبوا مخلوقات
+
+298
+00:30:16,040 --> 00:30:21,760
+او مخلوقات؟ مخلوقات مع اس او بدون اس؟ مع اس مع اس
+
+299
+00:30:21,760 --> 00:30:26,140
+مع اس مع اس مع اس مع اس مع اس مع اس مع اس
+
+300
+00:30:53,540 --> 00:30:55,300
+ملايين من السنين من السنين
+
+301
+00:31:09,640 --> 00:31:15,400
+these wings changed and the birds adapted to their
+
+302
+00:31:15,400 --> 00:31:21,160
+environment plural thank you next one
+
+303
+00:31:34,720 --> 00:31:39,160
+prince of wood was fish now just a minute which
+
+304
+00:31:39,160 --> 00:31:42,540
+one did you choose can you tell me what's the
+
+305
+00:31:42,540 --> 00:31:45,640
+difference between this word and that word no no
+
+306
+00:31:45,640 --> 00:31:50,900
+no she can she can yeah this is apostrophe s and
+
+307
+00:31:50,900 --> 00:31:54,280
+the other one is apostrophe what's the difference
+
+308
+00:31:54,280 --> 00:31:57,980
+between them it's a plural okay this is a plural
+
+309
+00:31:57,980 --> 00:32:00,620
+very good and this is what singular thank you very
+
+310
+00:32:00,620 --> 00:32:05,380
+much you are right go onso which one do we want
+
+311
+00:32:05,380 --> 00:32:13,860
+the second good food was fish yes food was food
+
+312
+00:32:13,860 --> 00:32:18,180
+fish good penguins needed to be able to swim to
+
+313
+00:32:18,180 --> 00:32:26,400
+find their food so eventually their wings their
+
+314
+00:32:26,400 --> 00:32:31,020
+wings good evolved
+
+315
+00:32:31,020 --> 00:32:39,840
+into suckersflippers yeah in apple
+
+316
+00:32:39,840 --> 00:32:44,720
+them them good thank
+
+317
+00:32:44,720 --> 00:32:49,880
+you very much good yes yes please
+
+318
+00:32:59,580 --> 00:33:08,000
+no questions on the exercise you should understand
+
+319
+00:33:08,000 --> 00:33:12,560
+before you write if you don't understand ask why
+
+320
+00:33:12,560 --> 00:33:20,840
+this not that go on thank
+
+321
+00:33:20,840 --> 00:33:25,560
+you in water yes
+
+322
+00:33:25,560 --> 00:33:32,180
+eggs on landwater eggs on land thank you next one
+
+323
+00:33:32,180 --> 00:33:47,920
+yes please come very
+
+324
+00:33:47,920 --> 00:33:52,860
+good thank you what about the others new ones the
+
+325
+00:33:52,860 --> 00:33:59,290
+same faces every time what about the othersyes
+
+326
+00:33:59,290 --> 00:34:06,750
+come sorry
+
+327
+00:34:06,750 --> 00:34:09,850
+who
+
+328
+00:34:09,850 --> 00:34:17,050
+can answer her question why not habit we say
+
+329
+00:34:17,050 --> 00:34:18,870
+habits why do we use the plural
+
+330
+00:34:23,710 --> 00:34:28,350
+Now habit this is a singular count noun okay now
+
+331
+00:34:28,350 --> 00:34:36,170
+if I say can I tell you take red pen take red pen
+
+332
+00:34:36,170 --> 00:34:40,610
+or this red pen I cannot say this red pen or black
+
+333
+00:34:40,610 --> 00:34:46,370
+pen I should say this is a red pen or this is the
+
+334
+00:34:46,370 --> 00:34:51,410
+black pentake this black pen so the singular
+
+335
+00:34:51,410 --> 00:34:55,770
+should be used with a pronoun with an article okay
+
+336
+00:34:55,770 --> 00:34:58,390
+should be preceded by things like that I cannot
+
+337
+00:34:58,390 --> 00:35:04,150
+say you know have interesting what so after that
+
+338
+00:35:04,150 --> 00:35:08,930
+we should use a plural noun okay if I say they
+
+339
+00:35:08,930 --> 00:35:11,990
+have an interesting yeah an interesting yeah
+
+340
+00:35:11,990 --> 00:35:16,310
+that's right an interesting I cannot say I read
+
+341
+00:35:17,240 --> 00:35:22,760
+book on sea animals for example I read a book I
+
+342
+00:35:22,760 --> 00:35:27,140
+read this book I read my book your book and so on
+
+343
+00:35:27,140 --> 00:35:38,480
+ده go on please اه اه ا clean ا clean
+
+344
+00:35:38,480 --> 00:35:44,060
+the
+
+345
+00:35:44,060 --> 00:35:52,030
+female likesالفتاة لز جيدة واحد
+
+346
+00:35:52,030 --> 00:35:56,530
+أجهزة واحد أجهزة أنت محق؟ على الزرع؟ في المنطقة
+
+347
+00:35:56,530 --> 00:36:01,370
+الأطلسية و بعد ذلك يرجع الى المحيط رجع الى المحيط
+
+348
+00:36:01,370 --> 00:36:06,730
+شكرا جيد أجل أرجوك
+
+349
+00:36:06,730 --> 00:36:13,440
+لز واحد أجهزة؟ حسنا اذهب اذهبafter the female lays
+
+350
+00:36:13,440 --> 00:36:21,980
+the egg, the male takes over he covers the egg
+
+351
+00:36:21,980 --> 00:36:30,580
+with his body until she has it now just a minute
+
+352
+00:36:30,580 --> 00:36:36,240
+what is the antecedent of she if you want to use
+
+353
+00:36:36,240 --> 00:36:41,350
+she, she refers to what?Okay the egg ate thank you
+
+354
+00:36:41,350 --> 00:36:49,910
+that's right yes come please
+
+355
+00:36:49,910 --> 00:37:01,370
+okay
+
+356
+00:37:01,370 --> 00:37:11,420
+during now why these why these this okaytakes just
+
+357
+00:37:11,420 --> 00:37:19,080
+a minute takes okay weeks during this doesn't eat
+
+358
+00:37:19,080 --> 00:37:34,460
+thank you yeah next one فضلي hatches
+
+359
+00:37:34,460 --> 00:37:42,760
+the egg hatches yeahيأخذ الشباب و يذهب الى المحيط
+
+360
+00:37:42,760 --> 00:37:53,900
+لتجد طفل من نفسه و بعد ذلك يأخذ أبناء أبناء
+
+361
+00:37:53,900 --> 00:37:57,060
+أبناء أبناء أبناء أبناء أبناء أبناء أبناء أبناء
+
+362
+00:37:57,060 --> 00:37:57,140
+أبناء أبناء أبناء أبناء أبناء أبناء أبناء أبناء
+
+363
+00:37:57,140 --> 00:37:58,160
+أبناء أبناء أبناء أبناء أبناء أبناء أبناء أبناء
+
+364
+00:37:58,160 --> 00:38:01,440
+أبناء أبناء أبناء أبناء أبناء أبناء أبناء أبناء
+
+365
+00:38:01,440 --> 00:38:05,920
+أبناء أبناء أبناء أبناء أبناءالأولى بدون S انت
+
+366
+00:38:05,920 --> 00:38:12,700
+محق، جيد، لكن لماذا؟ الان
+
+367
+00:38:12,700 --> 00:38:25,880
+قلنا offspring، fish، deer، حيوان،
+
+368
+00:38:25,880 --> 00:38:32,080
+حيوان، حيوان، حيواننحن نقول ماذا؟ أبناء هو و أبناء
+
+369
+00:38:32,080 --> 00:38:35,880
+هم. الفحر هو و الفحر هم.
+
+370
+00:38:38,300 --> 00:38:42,460
+حيوان هو و حيوان هم. أنت محقة. لذا مرة أخرى، لا S.
+
+371
+00:38:42,580 --> 00:38:48,080
+أنت محقة. شكرا جدا. جيد. والأخير، أخبرني. نعم،
+
+372
+00:38:48,080 --> 00:38:58,480
+ماذا يجب أن أكتب؟ بنجون أو بنجون؟ بنجون. شكرا.in a
+
+373
+00:38:58,480 --> 00:39:03,800
+harsh environment okay environment now why the
+
+374
+00:39:03,800 --> 00:39:08,860
+singular not the plural no no no she is speaking
+
+375
+00:39:08,860 --> 00:39:15,400
+listen listen she can answer now
+
+376
+00:39:15,400 --> 00:39:23,420
+we use look at the indefinite article a okay it
+
+377
+00:39:23,420 --> 00:39:31,120
+precedes whata singular now so okay go on they
+
+378
+00:39:31,120 --> 00:39:37,980
+need they need you are right thank you very much
+
+379
+00:39:37,980 --> 00:39:42,980
+okay this is enough for today thank you
+
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/W_Qo-nUZcl8_raw.json b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/W_Qo-nUZcl8_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..f926d1de338309e9a1d3ba2b3a89c9904ee8d036
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/W_Qo-nUZcl8_raw.json
@@ -0,0 +1 @@
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Just a minute, when I say farmers, farmers in general, it is right, farmers are a group of people, but are they a specific group of people? 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"end": 1383.77, "text": "أو تعرفين .. أعطيني رمز أخر لك .. هل لديك رمز أخر؟ نعم أريد من هنا شكرا .. انظر لدي ثلاثة رمز", "tokens": [10721, 2407, 37279, 28480, 9957, 4386, 5551, 3615, 9566, 9957, 1829, 12602, 2304, 11622, 5551, 34740, 5296, 4117, 4386, 8032, 1211, 5296, 16254, 4117, 12602, 2304, 11622, 5551, 34740, 22807, 8717, 25957, 5551, 16572, 3215, 9154, 34105, 13412, 4117, 23557, 4386, 16472, 19913, 2288, 5296, 16254, 38637, 1211, 5718, 104, 3660, 12602, 2304, 11622], "avg_logprob": -0.36960226730866863, "compression_ratio": 1.394736842105263, "no_speech_prob": 0.0, "words": [{"start": 1367.6499999999999, "end": 1368.57, "word": "أو", "probability": 0.787841796875}, {"start": 1368.57, "end": 1369.49, "word": " تعرفين", "probability": 0.5396321614583334}, {"start": 1369.49, "end": 1370.53, "word": " ..", "probability": 0.311279296875}, {"start": 1370.53, "end": 1371.35, "word": " أعطيني", "probability": 0.733056640625}, {"start": 1371.35, "end": 1371.71, "word": " رمز", 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another you are right thank you", "tokens": [5479, 630, 291, 584, 1071, 291, 366, 558, 1309, 291], "avg_logprob": -0.4343039881099354, "compression_ratio": 0.96, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 2240.9599999999996, "end": 2241.8399999999997, "word": "what", "probability": 0.05938720703125}, {"start": 2241.8399999999997, "end": 2242.72, "word": " did", "probability": 0.931640625}, {"start": 2242.72, "end": 2247.38, "word": " you", "probability": 0.96484375}, {"start": 2247.38, "end": 2247.66, "word": " say", "probability": 0.958984375}, {"start": 2247.66, "end": 2248.24, "word": " another", "probability": 0.3671875}, {"start": 2248.24, "end": 2249.08, "word": " you", "probability": 0.80908203125}, {"start": 2249.08, "end": 2249.22, "word": " are", "probability": 0.85791015625}, {"start": 2249.22, "end": 2249.52, "word": " right", "probability": 0.931640625}, {"start": 2249.52, "end": 2249.8, "word": " thank", "probability": 0.810546875}, {"start": 2249.8, "end": 2250.08, "word": " you", "probability": 0.966796875}], "temperature": 1.0}, {"id": 89, "seek": 226307, "start": 2255.33, "end": 2263.07, "text": "شكرا جزيلا و إذا كان لديك أي سؤال عن الاخرين أو الاخرين أو الاخرين أي سؤال انا أيضا", "tokens": [8592, 4117, 23557, 10874, 11622, 1829, 15040, 4032, 11933, 15730, 25961, 5296, 16254, 4117, 36632, 8608, 33604, 6027, 18871, 2423, 47283, 2288, 9957, 34051, 2423, 47283, 2288, 9957, 34051, 2423, 47283, 2288, 9957, 36632, 8608, 33604, 6027, 1975, 8315, 36632, 11242, 995], "avg_logprob": -0.47783431341481764, "compression_ratio": 1.7126436781609196, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2255.33, "end": 2255.69, "word": "شكرا", "probability": 0.734375}, {"start": 2255.69, "end": 2255.97, "word": " جزيلا", "probability": 0.8482666015625}, {"start": 2255.97, "end": 2256.45, "word": " و", "probability": 0.39208984375}, {"start": 2256.45, "end": 2256.63, "word": " إذا", "probability": 0.56597900390625}, {"start": 2256.63, "end": 2256.81, "word": " كان", "probability": 0.78466796875}, {"start": 2256.81, "end": 2257.07, "word": " لديك", "probability": 0.8165690104166666}, {"start": 2257.07, "end": 2257.07, "word": " أي", "probability": 0.471435546875}, {"start": 2257.07, "end": 2257.51, "word": " سؤال", "probability": 0.8202311197916666}, {"start": 2257.51, "end": 2257.75, "word": " عن", "probability": 0.471923828125}, {"start": 2257.75, "end": 2258.41, "word": " الاخرين", "probability": 0.66046142578125}, {"start": 2258.41, "end": 2258.53, "word": " أو", "probability": 0.45068359375}, {"start": 2258.53, "end": 2259.01, "word": " الاخرين", "probability": 0.674468994140625}, {"start": 2259.01, "end": 2259.01, "word": " أو", "probability": 0.6474609375}, {"start": 2259.01, "end": 2259.57, "word": " الاخرين", "probability": 0.807861328125}, {"start": 2259.57, "end": 2261.33, "word": " أي", "probability": 0.29736328125}, {"start": 2261.33, "end": 2262.01, "word": " سؤال", "probability": 0.9855143229166666}, {"start": 2262.01, "end": 2262.55, "word": " انا", "probability": 0.529541015625}, {"start": 2262.55, "end": 2263.07, "word": " أيضا", "probability": 0.8221028645833334}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2273.28, "duration_after_vad": 2097.396874999994}
\ No newline at end of file
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/_edjjUoOcpA_postprocess.srt b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/_edjjUoOcpA_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..38fecbd3754b81fcf7bfca635d7eab94b9e6fc38
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/_edjjUoOcpA_postprocess.srt
@@ -0,0 +1,1416 @@
+1
+00:00:21,180 --> 00:00:26,140
+Good morning to you all. How are you today? Last
+
+2
+00:00:26,140 --> 00:00:28,360
+time we started talking about the phrases
+
+3
+00:00:45,290 --> 00:00:53,190
+the underlined words yes please a finite verb yes
+
+4
+00:00:53,190 --> 00:00:57,550
+a phrase what type of phrase adjective phrase
+
+5
+00:00:57,550 --> 00:01:02,200
+adjective phrase very good becauseit describes the
+
+6
+00:01:02,200 --> 00:01:05,780
+noun thank you very much and what would you like
+
+7
+00:01:05,780 --> 00:01:09,140
+to say about the other sentence yes please don't
+
+8
+00:01:09,140 --> 00:01:12,760
+talk like that without phrases and verbs because
+
+9
+00:01:12,760 --> 00:01:17,960
+they are describing very good don't talk how like
+
+10
+00:01:17,960 --> 00:01:21,480
+that okay thank you very much any question about
+
+11
+00:01:21,480 --> 00:01:22,500
+the brief just material
+
+12
+00:01:38,240 --> 00:01:41,900
+الأن، انظروا إلى الأمثلة، من يرغب في قراءة الأولة
+
+13
+00:01:41,900 --> 00:01:47,040
+من الأمثلة؟ نعم، بفضل الله. He wants to go home.
+
+14
+00:01:47,160 --> 00:01:52,660
+He wants what؟ He wants what؟ To go home. He wants
+
+15
+00:01:52,660 --> 00:01:54,960
+to go home. Where is the object؟
+
+16
+00:01:57,310 --> 00:02:04,130
+الأن إسمع ، الوضع عادةً مجرد إجابة لماذا أكلت في
+
+17
+00:02:04,130 --> 00:02:09,490
+فيلم؟ ماذا أكلت؟ رأيت فيلم؟ ماذا رأيت؟ قرأت كتابة؟
+
+18
+00:02:09,490 --> 00:02:16,430
+ماذا قرأت؟ الوضع عادةً مجرد إجابة لماذا؟ هو يريد
+
+19
+00:02:16,430 --> 00:02:20,770
+ماذا؟ الذهاب للمنزل ، شكراً ، لذلك أين هو الوضع
+
+20
+00:02:20,770 --> 00:02:28,980
+مجدداً؟ الذهاب للمنزل ، الوضع دائماً مسمىالوضع
+
+21
+00:02:28,980 --> 00:02:33,800
+دائمًا نوعًا. تذكرين عندما كنا نتكلم عن الفرازات
+
+22
+00:02:33,800 --> 00:02:38,610
+التجاربية و الفرازات التجاربية، قالناit is an
+
+23
+00:02:38,610 --> 00:02:43,410
+adjective phrase because it acts it behaves as an
+
+24
+00:02:43,410 --> 00:02:46,950
+adjective it is an adverb phrase because it
+
+25
+00:02:46,950 --> 00:02:52,830
+behaves as an adverb but this is a noun phrase is
+
+26
+00:02:52,830 --> 00:02:55,970
+used as the noun as the object the object is the
+
+27
+00:02:55,970 --> 00:02:59,990
+noun so now it is the noun it is the object so the
+
+28
+00:02:59,990 --> 00:03:03,310
+phrase itself is the object look at the other
+
+29
+00:03:03,310 --> 00:03:08,730
+sentence yes ياسمينأنا حاولت أن أحصل على الوضع
+
+30
+00:03:08,730 --> 00:03:14,250
+صحيح حاولت ماذا؟ حاولت أن أحصل على الوضع صحيح حسنا
+
+31
+00:03:14,250 --> 00:03:19,010
+شكرا اذا أين الموضوع نفين؟ لأحصل على الوضع صحيح
+
+32
+00:03:19,010 --> 00:03:26,150
+شكرا جدا اقرأ الاخر حنين الوضع صحيح الأن أين
+
+33
+00:03:26,150 --> 00:03:34,510
+الموضوع؟ عندما أقول هذا هو مهتمتي أين الموضوع؟مرة
+
+34
+00:03:34,510 --> 00:03:41,330
+أخرى، فقط لحظة، انتظر، اعطيها فرصة اجابة ايه
+
+35
+00:03:41,330 --> 00:03:43,210
+الموضوع؟ اجابة ايه الموضوع؟ اجابة ايه الموضوع؟
+
+36
+00:03:43,210 --> 00:03:44,210
+اجابة ايه الموضوع؟ اجابة ايه الموضوع؟ اجابة ايه
+
+37
+00:03:44,210 --> 00:03:45,450
+الموضوع؟ اجابة ايه الموضوع؟ اجابة ايه الموضوع؟
+
+38
+00:03:45,450 --> 00:03:46,110
+اجابة ايه الموضوع؟ اجابة ايه الموضوع؟ اجابة ايه
+
+39
+00:03:46,110 --> 00:03:50,250
+اجابة ايه الموضوع؟ اجابة
+
+40
+00:03:50,250 --> 00:03:56,150
+ايه الموضوع؟ اجابة ايه الموضوع؟ اجابة ا
+
+41
+00:03:59,460 --> 00:04:04,280
+we call it a noun phrase because it acts like the
+
+42
+00:04:04,280 --> 00:04:08,140
+subject or object it is the subject it is the
+
+43
+00:04:08,140 --> 00:04:11,620
+subject or the object okay and the subjects and
+
+44
+00:04:11,620 --> 00:04:16,140
+the objects are usually nouns are always nouns we
+
+45
+00:04:16,140 --> 00:04:19,680
+cannot use other words as subjects or as objects
+
+46
+00:04:19,680 --> 00:04:23,900
+they are usually nouns so a noun phrase is used as
+
+47
+00:04:23,900 --> 00:04:27,540
+the object or as the subject of the sentence is
+
+48
+00:04:27,540 --> 00:04:33,600
+that okayالأن، انظروا لهذا التعليم، رقم واحد، نور،
+
+49
+00:04:33,600 --> 00:04:36,600
+هل يمكنك أن تقرأ؟ اختار الفرازات الموجودة في
+
+50
+00:04:36,600 --> 00:04:39,360
+التعليقات التالية، نعم، أين هي الفرازات الموجودة؟
+
+51
+00:04:39,360 --> 00:04:45,480
+جيد، أبوه أراد أن يتحدث للعلمان الداهيد، نعم، أبوه
+
+52
+00:04:45,480 --> 00:04:51,200
+أراد، نعم، أين الفرازة؟ تتحدث، تتحدث، تتحدث،
+
+53
+00:04:51,200 --> 00:04:52,220
+تتحدث، تتحدث، تتحدث، تتحدث، تتحدث، تتحدث، تتحدث،
+
+54
+00:04:52,220 --> 00:04:52,420
+تتحدث، تتحدث، تتحدث، تتحدث، تتحدث، تتحدث، تتحدث،
+
+55
+00:04:52,420 --> 00:04:55,420
+تتحدث، تتحدث، تتحدث، تتحدث، تتحدث
+
+56
+00:04:58,940 --> 00:05:02,300
+to speak to the headmaster so where is the phrase
+
+57
+00:05:02,300 --> 00:05:07,540
+again to speak this is the object okay this is the
+
+58
+00:05:07,540 --> 00:05:12,820
+object why it is the object okay sorry if this is
+
+59
+00:05:12,820 --> 00:05:15,640
+a noun phrase why it is a noun phrase because it
+
+60
+00:05:15,640 --> 00:05:19,020
+is the object of the sentence thank you very much
+
+61
+00:05:19,020 --> 00:05:25,560
+good yes please next one to manage my studentsI
+
+62
+00:05:25,560 --> 00:05:29,540
+dislike what very good this is the noun phrase
+
+63
+00:05:29,540 --> 00:05:34,640
+thank you very much good next one yes please he
+
+64
+00:05:34,640 --> 00:05:38,100
+denies stealing the money he denies what stealing
+
+65
+00:05:38,100 --> 00:05:42,240
+the money okay stealing the money thank you yeah
+
+66
+00:05:42,240 --> 00:05:48,360
+have you ever tried climbing a mountain climbing a
+
+67
+00:05:48,360 --> 00:05:53,660
+mountain very good tried what climbing a mountain
+
+68
+00:05:53,660 --> 00:05:56,820
+thank you very muchHorses prefer living in dark
+
+69
+00:05:56,820 --> 00:06:00,380
+stables Yes
+
+70
+00:06:00,380 --> 00:06:05,080
+prefer what? Living in okay dark stables good Now
+
+71
+00:06:05,080 --> 00:06:10,160
+these are the answers you can look at them What
+
+72
+00:06:10,160 --> 00:06:14,860
+about the prepositional phrase?الان تحدثنا عن
+
+73
+00:06:14,860 --> 00:06:20,200
+الفرصة التجارية والفرصة التجارية والفرصة التجارية
+
+74
+00:06:20,200 --> 00:06:22,820
+والفرصة التجارية والفرصة التجارية والفرصة التجارية
+
+75
+00:06:22,820 --> 00:06:25,000
+والفرصة التجارية والفرصة التجارية والفرصة التجارية
+
+76
+00:06:25,000 --> 00:06:25,460
+والفرصة التجارية والفرصة التجارية والفرصة التجارية
+
+77
+00:06:25,460 --> 00:06:25,620
+والفرصة التجارية والفرصة التجارية والفرصة التجارية
+
+78
+00:06:25,620 --> 00:06:29,820
+والفرصة التجارية والفرصة التجارية والفرصة التجارية
+
+79
+00:06:29,820 --> 00:06:34,160
+والفرصة التجارية والفرصة التجارية والفرصة التجارية
+
+80
+00:06:34,160 --> 00:06:38,680
+والفرصة التجارية والفرصة التجارية والفرصة التجارية
+
+81
+00:06:38,680 --> 00:06:47,710
+والفانا و نيكولاس how؟ now let's see if you look
+
+82
+00:06:47,710 --> 00:06:51,670
+at this example when I say at home I have
+
+83
+00:06:51,670 --> 00:06:57,310
+preposition and now in time preposition and now
+
+84
+00:06:57,310 --> 00:07:06,570
+okay from sue preposition and with me for youby
+
+85
+00:07:06,570 --> 00:07:15,930
+singing by sleeping by eating okay this is gerund
+
+86
+00:07:15,930 --> 00:07:20,690
+now as you see they are prepositional phrases they
+
+87
+00:07:20,690 --> 00:07:25,430
+are made of a preposition and a noun a pronoun or
+
+88
+00:07:25,430 --> 00:07:33,610
+a gerund now look about what we needعن ما نحتاجه ،
+
+89
+00:07:33,610 --> 00:07:39,190
+لدينا مصطلح ومصطلح نوني مصطلح نوني مصطلح نوني
+
+90
+00:07:39,190 --> 00:07:43,410
+مصطلح نوني مصطلح نوني مصطلح نوني مصطلح نوني مصطلح
+
+91
+00:07:43,410 --> 00:07:43,590
+نوني مصطلح نوني مصطلح نوني مصطلح نوني مصطلح نوني
+
+92
+00:07:43,590 --> 00:07:43,770
+مصطلح نوني مصطلح نوني مصطلح نوني مصطلح نوني مصطلح
+
+93
+00:07:43,770 --> 00:07:44,530
+نوني مصطلح نوني مصطلح نوني مصطلح نوني مصطلح نوني
+
+94
+00:07:44,530 --> 00:07:49,990
+مصطلح نوني مصطلح نوني مصطلح نوني
+
+95
+00:07:49,990 --> 00:07:59,130
+مصطلح نوني مصطلح نون
+
+96
+00:07:59,500 --> 00:08:06,040
+أموديفير is a specifier it specifies the noun when
+
+97
+00:08:06,040 --> 00:08:10,800
+I say grandmother it can be any grandmother when I
+
+98
+00:08:10,800 --> 00:08:17,500
+say your grandmother it's okay my grandmother it
+
+99
+00:08:17,500 --> 00:08:22,480
+made the noun specific so we use what a
+
+100
+00:08:22,480 --> 00:08:28,140
+preposition a modifier and a noun under the warm
+
+101
+00:08:28,140 --> 00:08:34,960
+blanketagain we use a preposition and modifiers
+
+102
+00:08:34,960 --> 00:08:43,320
+okay and now good now we know what is a
+
+103
+00:08:43,320 --> 00:08:48,200
+prepositional phrase at least it is made up of a
+
+104
+00:08:48,200 --> 00:08:49,340
+preposition and
+
+105
+00:08:52,020 --> 00:08:57,460
+pronoun or gerund or pronounic clause it can be
+
+106
+00:08:57,460 --> 00:09:01,800
+expanded we can use also modifiers in a noun in a
+
+107
+00:09:01,800 --> 00:09:05,160
+prepositional phrase a prepositional phrase
+
+108
+00:09:05,160 --> 00:09:12,180
+usually behaves as an adjective or as an adverb
+
+109
+00:09:12,860 --> 00:09:17,100
+Okay, so it functions usually as what? An
+
+110
+00:09:17,100 --> 00:09:20,880
+adjective or an adverb? How can I distinguish
+
+111
+00:09:20,880 --> 00:09:24,360
+between this and that? If you look at this example
+
+112
+00:09:24,360 --> 00:09:28,600
+Yeah, who wants to read the example? Yes please
+
+113
+00:09:28,600 --> 00:09:33,440
+دعا The book on the bathroom floor is stolen from
+
+114
+00:09:33,440 --> 00:09:36,800
+a shower stand Thank you, now the book on which
+
+115
+00:09:36,800 --> 00:09:42,900
+one?which one so it answers the question which one
+
+116
+00:09:42,900 --> 00:09:46,180
+if it answers the question which one it is an
+
+117
+00:09:46,180 --> 00:09:50,200
+adjective phrase okay it functions as an adjective
+
+118
+00:09:50,200 --> 00:09:55,460
+phrase okay so a prepositional phrase when answers
+
+119
+00:09:55,460 --> 00:10:00,840
+the question which one it functions asan adjective
+
+120
+00:10:00,840 --> 00:10:04,200
+phrase، good، now which book .. now look at the
+
+121
+00:10:04,200 --> 00:10:07,220
+other one, who can read the example؟ yes خديجة؟
+
+122
+00:10:07,220 --> 00:10:10,040
+the sweet potatoes in the vegetable bin are green
+
+123
+00:10:10,040 --> 00:10:15,490
+with mold okay which ones?Which ones? So this
+
+124
+00:10:15,490 --> 00:10:19,510
+prepositional phrase functions as what? An
+
+125
+00:10:19,510 --> 00:10:23,570
+adjective phrase. Now what about the prepositional
+
+126
+00:10:23,570 --> 00:10:27,330
+phrase when it functions as an adverb? When it
+
+127
+00:10:27,330 --> 00:10:31,910
+functions as an adverb, you know, adverb phrases
+
+128
+00:10:31,910 --> 00:10:35,870
+and clauses usually answer questions like what,
+
+129
+00:10:36,510 --> 00:10:45,450
+like why, how, when, where, okay?Now فادي يا who
+
+130
+00:10:45,450 --> 00:10:52,410
+wants to read the example حنين okay
+
+131
+00:10:52,410 --> 00:10:54,950
+فادي is stiff from yesterday's long football
+
+132
+00:10:54,950 --> 00:10:58,490
+practice thank you how did he get stiff from
+
+133
+00:10:58,490 --> 00:11:03,250
+yesterday so it answers what how it answers how so
+
+134
+00:11:03,250 --> 00:11:07,890
+it functions as adverb very good read the other
+
+135
+00:11:07,890 --> 00:11:08,650
+one please
+
+136
+00:11:14,490 --> 00:11:21,790
+Okay when did jihad do this? before class okay so
+
+137
+00:11:21,790 --> 00:11:27,250
+before class this is a prepositional phrase it
+
+138
+00:11:27,250 --> 00:11:33,570
+acts or functions as thank you and finally finally
+
+139
+00:11:33,570 --> 00:11:34,510
+yes please read
+
+140
+00:11:41,510 --> 00:11:47,750
+Okay where did we try the food okay so again this
+
+141
+00:11:47,750 --> 00:11:51,230
+is what what would you say about this point yes
+
+142
+00:11:51,230 --> 00:11:58,010
+what would you say a propositional phrase adverb
+
+143
+00:11:58,010 --> 00:12:04,220
+okay thank you very much good nowلنعود إلى
+
+144
+00:12:04,220 --> 00:12:09,840
+الاختصارات حسنا؟ لذلك تحدثنا عن أربع نوع من
+
+145
+00:12:09,840 --> 00:12:18,760
+الفرازين لنعود إلى الاختصارات أولا ماهي اختصار؟
+
+146
+00:12:18,760 --> 00:12:26,340
+قلنا ان الفراز مجموعة من كلمات متعلقة بدون كلمة
+
+147
+00:12:26,340 --> 00:12:34,040
+معينة بدون ماهي كلمة؟ كلمة معينة و بدون؟Okay of
+
+148
+00:12:34,040 --> 00:12:38,760
+course, no verb, no subject, no complete sense. So
+
+149
+00:12:38,760 --> 00:12:44,780
+if this group of words contains a finite verb, has
+
+150
+00:12:44,780 --> 00:12:48,860
+a subject and a predicate, first of all, what is
+
+151
+00:12:48,860 --> 00:12:50,880
+the subject and what is the predicate? Who can
+
+152
+00:12:50,880 --> 00:12:51,680
+give me a sentence?
+
+153
+00:12:54,800 --> 00:12:56,080
+Give me a sentence
+
+154
+00:13:02,360 --> 00:13:07,060
+again give me any sentence I bought a red shirt I
+
+155
+00:13:07,060 --> 00:13:19,680
+bought a red shirt where is the subject I now
+
+156
+00:13:19,680 --> 00:13:23,220
+everything said about the subject is called a
+
+157
+00:13:23,220 --> 00:13:28,280
+predicate everything said about the subject is
+
+158
+00:13:28,280 --> 00:13:35,800
+called what? predicateالقصة تحتوي على أساسين أساسي
+
+159
+00:13:35,800 --> 00:13:44,240
+و مجلس ومجلس ومجلس ومجلس ومجلس ومجلس ومجلس ومجلس
+
+160
+00:13:44,240 --> 00:13:46,200
+ومجلس ومجلس ومجلس ومجلس ومجلس ومجلس ومجلس ومجلس
+
+161
+00:13:46,200 --> 00:13:50,340
+ومجلس ومجلس ومجلس ومجلس ومجلس ومجلس ومجلس
+
+162
+00:14:00,420 --> 00:14:04,120
+I bought a bag okay tell me about where is the
+
+163
+00:14:04,120 --> 00:14:08,600
+subject and the predicate I is a subject and
+
+164
+00:14:08,600 --> 00:14:12,320
+bought a bag is a predicate thank you the weather
+
+165
+00:14:12,320 --> 00:14:16,260
+is getting very cold the weather is getting very
+
+166
+00:14:16,260 --> 00:14:22,880
+cold yeah subject and it's getting very cold is
+
+167
+00:14:22,880 --> 00:14:28,700
+the predicate thank you now lookhe has a chain
+
+168
+00:14:28,700 --> 00:14:34,300
+which
+
+169
+00:14:34,300 --> 00:14:41,160
+is made of gold it is made of
+
+170
+00:14:41,160 --> 00:14:45,060
+gold look at the underlying group of words it has
+
+171
+00:14:45,060 --> 00:14:48,860
+a subject and it has a predicate
+
+172
+00:14:52,380 --> 00:14:57,700
+هل يعطيك مفهوم كام؟ نعم، نعم، نعم، نعم، نعم، نعم،
+
+173
+00:14:57,700 --> 00:14:58,640
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+174
+00:14:58,640 --> 00:15:00,700
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+175
+00:15:00,700 --> 00:15:01,500
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+176
+00:15:01,500 --> 00:15:03,460
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+177
+00:15:03,460 --> 00:15:03,940
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+178
+00:15:03,940 --> 00:15:09,360
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+179
+00:15:09,360 --> 00:15:15,540
+نعم، نعم، نعم، نعم، ن
+
+180
+00:15:18,640 --> 00:15:22,780
+الان دعونا نرى، هذه المجموعة من الكلمات تحتوي على
+
+181
+00:15:22,780 --> 00:15:27,300
+موضوع و مصطلح و بالطبع المصطلح يحتوي على كلمة
+
+182
+00:15:27,300 --> 00:15:32,600
+معينة، لديها كلمة معينة، كلمة التي تحتوي على مصطلح
+
+183
+00:15:32,600 --> 00:15:36,020
+مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح
+
+184
+00:15:36,020 --> 00:15:36,500
+مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح
+
+185
+00:15:36,500 --> 00:15:37,380
+مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح
+
+186
+00:15:37,380 --> 00:15:41,720
+مصطلح مصطلح مصطلح مصطلح
+
+187
+00:15:41,720 --> 00:15:44,960
+مصطلح
+
+188
+00:15:44,960 --> 00:15:55,200
+موما هو فرصة مفتوحة؟ ما هو؟ هو الشخص اللي يتحدث
+
+189
+00:15:55,200 --> 00:16:04,110
+عننا، ومفتوحة مفتوحة هي الشخص الليماذا يسمى الفرصة
+
+190
+00:16:04,110 --> 00:16:10,550
+الاضافية؟ هي التي تسمي الفرصة وهي تسمي الفرصة، جيد
+
+191
+00:16:10,550 --> 00:16:15,470
+جدا، ويعادة تجيب على أسئلة مثل أين، أين، كيف،
+
+192
+00:16:15,470 --> 00:16:17,770
+وكذلك، وكذلك، وكذلك، وكذلك، وكذا، وكذا، وكذا،
+
+193
+00:16:17,770 --> 00:16:18,410
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا،
+
+194
+00:16:18,410 --> 00:16:20,370
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا،
+
+195
+00:16:20,370 --> 00:16:20,890
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا،
+
+196
+00:16:20,890 --> 00:16:21,510
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، و
+
+197
+00:16:21,700 --> 00:16:26,740
+الأن، ماذا عن الفرسة الاسمية؟ انها الوضع أو الوضع
+
+198
+00:16:26,740 --> 00:16:31,700
+و الوضع أو الوضع و القرصة الاسمية تستخدم أيضًا
+
+199
+00:16:31,700 --> 00:16:38,280
+كوضع و وضع. حسنًا؟ حسنًا، حسنًا، حسنًا، حسنًا،
+
+200
+00:16:38,280 --> 00:16:38,380
+حسنًا، حسنًا، حسنًا، حسنًا، حسنًا، حسنًا، حسنًا،
+
+201
+00:16:38,380 --> 00:16:48,100
+حسنًا، حسنًا، حسنًا، حسنًا، حسنًا، حسنًا، حسنًا،
+
+202
+00:16:48,100 --> 00:16:53,250
+حسنًOkay, there is a subject and a predicate.
+
+203
+00:16:53,330 --> 00:16:56,050
+Good. So, the underlined group of words.
+
+204
+00:16:59,430 --> 00:17:02,590
+Adverbic clause. Very good. Thank you. You miss it
+
+205
+00:17:02,590 --> 00:17:08,610
+where? Where? It qualifies the verb, right? You
+
+206
+00:17:08,610 --> 00:17:12,790
+miss it where? Wherever you like. Thank you very
+
+207
+00:17:12,790 --> 00:17:17,630
+much. Read the other one please. Yes, you. Yes.
+
+208
+00:17:18,630 --> 00:17:24,250
+Number two.he behaves as one might expect him to
+
+209
+00:17:24,250 --> 00:17:27,830
+do thank you yes who wants to comment on this
+
+210
+00:17:27,830 --> 00:17:32,990
+clause how
+
+211
+00:17:32,990 --> 00:17:40,330
+he behaves how as one might expect him to do okay
+
+212
+00:17:40,330 --> 00:17:46,630
+he behaves how okay next one pleaseif you eat too
+
+213
+00:17:46,630 --> 00:17:50,470
+much you will be ill if you eat too much this is
+
+214
+00:17:50,470 --> 00:17:55,370
+conditional okay okay
+
+215
+00:17:55,370 --> 00:17:59,550
+thank you when you eat too much you will be ill
+
+216
+00:17:59,550 --> 00:18:03,530
+okay now what would you say about adverbic clauses
+
+217
+00:18:03,530 --> 00:18:09,360
+tell me it's your turn to explain go onو ماذا
+
+218
+00:18:09,360 --> 00:18:14,420
+ستقول عن اكتشاف الكلمات الاساسي هي نادا ذهبت تعمل
+
+219
+00:18:14,420 --> 00:18:20,340
+عمل الكلمة تعمل عمل الكلمة تعمل عمل الكلمة تعمل
+
+220
+00:18:20,340 --> 00:18:20,560
+عمل الكلمة تعمل عمل الكلمة تعمل عمل الكلمة تعمل
+
+221
+00:18:20,560 --> 00:18:22,840
+عمل الكلمة تعمل عمل الكلمة تعمل عمل الكلمة تعمل
+
+222
+00:18:22,840 --> 00:18:25,820
+عمل الكلمة تعمل عمل الكلمة تعمل عمل الكلمة تعمل
+
+223
+00:18:25,820 --> 00:18:26,700
+عمل الكلمة تعمل عمل الكلمة تعمل عمل الكلمة تعمل
+
+224
+00:18:26,700 --> 00:18:34,540
+عمل الكلمة تعمل عمل الكلمة تعمل عمل الكلمة تعمل ع
+
+225
+00:18:41,220 --> 00:18:55,660
+بسبب أنك فعلت هذا سأعذبك لأنك
+
+226
+00:18:55,660 --> 00:18:59,460
+فعلت هذا لأنك فعلت هذا
+
+227
+00:19:07,700 --> 00:19:14,000
+فضلي number two why
+
+228
+00:19:14,000 --> 00:19:18,780
+why did I speak to his brother no no no she this
+
+229
+00:19:18,780 --> 00:19:23,460
+is for her yeah go on where is the adverbic clause
+
+230
+00:19:23,460 --> 00:19:25,380
+ask yourself why
+
+231
+00:19:29,590 --> 00:19:34,590
+لماذا كنت اتكلم مع أخيه؟ الان ماذا يعني بإنجليزي؟
+
+232
+00:19:34,590 --> 00:19:37,490
+ماذا يعني از؟ بسبب .. بسبب .. بسبب .. بسبب .. بسبب
+
+233
+00:19:37,490 --> 00:19:39,830
+.. بسبب .. بسبب .. بسبب .. بسبب .. بسبب .. بسبب ..
+
+234
+00:19:39,830 --> 00:19:41,810
+بسبب .. بسبب .. بسبب .. بسبب .. بسبب .. بسبب ..
+
+235
+00:19:41,810 --> 00:19:42,030
+بسبب .. بسبب .. بسبب .. بسبب .. بسبب .. بسبب ..
+
+236
+00:19:42,030 --> 00:19:42,210
+بسبب .. بسبب .. بسبب .. بسبب .. بسبب .. بسبب ..
+
+237
+00:19:42,210 --> 00:19:45,450
+بسبب .. بسبب .. بسبب .. بسبب .. بسبب .. بسبب ..
+
+238
+00:19:45,450 --> 00:19:54,110
+بسبب .. بسبب .. بسبب .. بسبب .. بسبب .. بسب
+
+239
+00:19:58,940 --> 00:20:11,040
+هل انت تنتظر حتى ارجع ؟ حتى ارجع ؟ حتى ارجع ؟ حتى
+
+240
+00:20:11,040 --> 00:20:19,980
+ارجع ؟ حتى ارجع ؟ حتى ارجع ؟ حتى ارجع ؟ حتى ارجع ؟
+
+241
+00:20:21,820 --> 00:20:27,720
+Okay when .. just as
+
+242
+00:20:27,720 --> 00:20:32,980
+he entered the room okay now when did the clock
+
+243
+00:20:32,980 --> 00:20:37,320
+what struck if I begin with dead what shall I say
+
+244
+00:20:37,320 --> 00:20:43,960
+one speaker when did the clock strike strike take
+
+245
+00:20:43,960 --> 00:20:48,100
+care okay when did the clock strike any question
+
+246
+00:20:48,100 --> 00:20:49,120
+on this exercise
+
+247
+00:20:55,670 --> 00:21:03,170
+adjective clauses adjective clauses okay now
+
+248
+00:21:03,170 --> 00:21:09,510
+number one read please say a little lamb a little
+
+249
+00:21:09,510 --> 00:21:16,470
+cat okay you know the lamb yes okay good whose
+
+250
+00:21:16,470 --> 00:21:17,030
+fleece
+
+251
+00:21:19,930 --> 00:21:25,930
+Okay now the underlined words whose fleece was as
+
+252
+00:21:25,930 --> 00:21:28,870
+white as snow yes what would you comment what
+
+253
+00:21:28,870 --> 00:21:30,710
+would you say about this group of words
+
+254
+00:21:35,690 --> 00:21:38,470
+it is adjective clause very good thank you why it
+
+255
+00:21:38,470 --> 00:21:41,470
+is an adjective clause yes please it has a subject
+
+256
+00:21:41,470 --> 00:21:47,190
+and a precedent and it behaves as an adjective
+
+257
+00:21:47,190 --> 00:21:51,450
+okay thank you behaves describes the noun نفين
+
+258
+00:21:51,450 --> 00:21:54,750
+number two the letter from money which was badly
+
+259
+00:21:54,750 --> 00:21:59,030
+needed okay what type of money okay money it
+
+260
+00:21:59,030 --> 00:22:03,250
+describes what money which was badly needed yes go
+
+261
+00:22:03,250 --> 00:22:04,490
+on نفين what would you say
+
+262
+00:22:07,350 --> 00:22:13,670
+عن الكلمات المصطلحة المال؟ حسنا، إنها كلمة مصطلحة
+
+263
+00:22:13,670 --> 00:22:15,010
+مصطلحة مصطلحة مصطلحة مصطلحة مصطلحة مصطلحة مصطلحة
+
+264
+00:22:15,010 --> 00:22:17,110
+مصطلحة مصطلحة مصطلحة مصطلحة مصطلحة مصطلحة مصطلحة
+
+265
+00:22:17,110 --> 00:22:20,150
+مصطلحة مصطلحة مصطلحة مصطلحة مصطلحة مصطلحة مصطلحة
+
+266
+00:22:20,150 --> 00:22:27,530
+مصطلحة مصطلحة مصطلحة مصطلحة
+
+267
+00:22:33,940 --> 00:22:41,200
+yes they never fail who die in a great cause okay
+
+268
+00:22:41,200 --> 00:22:48,320
+it means people who die it describes what the noun
+
+269
+00:22:48,320 --> 00:22:51,120
+thank you so what would you say about the
+
+270
+00:22:51,120 --> 00:22:56,300
+adjective classالقصة الاجيكتيفية محتوى عن موضوع
+
+271
+00:22:56,300 --> 00:23:01,580
+ومصطلح محتوى عن موضوع ومصطلح كالقصة الاخرى قصة
+
+272
+00:23:01,580 --> 00:23:05,100
+اجيكتيفية
+
+273
+00:23:05,100 --> 00:23:14,340
+اتفضلي
+
+274
+00:23:14,340 --> 00:23:16,920
+اين هي القصة الاجيكتيفية؟
+
+275
+00:23:24,150 --> 00:23:29,010
+the house that I live in with my father and three
+
+276
+00:23:29,010 --> 00:23:34,590
+daughters the house which house please we want one
+
+277
+00:23:34,590 --> 00:23:38,930
+speaker okay one speaker don't talk together she's
+
+278
+00:23:38,930 --> 00:23:47,210
+speaking yeah she can which house that I live in
+
+279
+00:23:47,210 --> 00:23:50,350
+very good now when I say the house it can be any
+
+280
+00:23:50,350 --> 00:23:56,470
+house rightالأدجكتف أيضًا يشرح النام، أليس كذلك؟
+
+281
+00:23:56,470 --> 00:24:00,490
+الادجكتف عندما أقول فتاة، يمكن أن تكون أي فتاة،
+
+282
+00:24:00,490 --> 00:24:04,430
+أليس كذلك؟ لكن الفتاة الطويلة .. الفتاة الطويلة
+
+283
+00:24:04,430 --> 00:24:10,830
+جعلت النام محدودًا، المنزل، المنزل الذي أعيش
+
+284
+00:24:10,830 --> 00:24:19,520
+فيهthat I live in yeah thank you which goes
+
+285
+00:24:19,520 --> 00:24:22,660
+in and out with me thank you that's right thank
+
+286
+00:24:22,660 --> 00:24:30,360
+you yeah that
+
+287
+00:24:30,360 --> 00:24:34,220
+bites doesn't okay the dog now again where is the
+
+288
+00:24:34,220 --> 00:24:40,770
+adjective clausethat bites that bites okay the dog
+
+289
+00:24:40,770 --> 00:24:46,690
+that bites which dog okay thank you yes please
+
+290
+00:24:46,690 --> 00:24:50,330
+okay
+
+291
+00:24:50,330 --> 00:24:54,150
+good
+
+292
+00:24:54,150 --> 00:24:58,050
+thank you and finally yes that
+
+293
+00:25:06,890 --> 00:25:16,190
+which now which wind which wind that blows nobody
+
+294
+00:25:16,190 --> 00:25:22,570
+any good okay that blows nobody any good okay it
+
+295
+00:25:22,570 --> 00:25:28,570
+describes what the noun good now you can look at
+
+296
+00:25:28,570 --> 00:25:35,890
+the answers and finally نعني clausesالان قصة نقل
+
+297
+00:25:35,890 --> 00:25:40,960
+من يريد أن يبدأ من يريد أن يتحدث انه حان دوركI
+
+298
+00:25:40,960 --> 00:25:43,900
+expect that I shall get a prize yes what will you
+
+299
+00:25:43,900 --> 00:25:47,400
+say about this sentence that I shall get a prize
+
+300
+00:25:47,400 --> 00:25:51,880
+it had a subject and a predicate a predicate so it
+
+301
+00:25:51,880 --> 00:25:55,260
+is a clause so what type of a clause it's not a
+
+302
+00:25:55,260 --> 00:25:59,580
+clause why because it has a subject it is a ..
+
+303
+00:25:59,580 --> 00:26:04,720
+listen it is a object very good it is the object
+
+304
+00:26:04,720 --> 00:26:07,280
+where is the object of the sentence I expect what
+
+305
+00:26:08,630 --> 00:26:13,310
+أتوقع أني أحصل على فائدة، حسنًا؟ لذلك، هذا هو
+
+306
+00:26:13,310 --> 00:26:19,830
+الوضع، صحيح؟ هذا هو الوضع، بالطبع، لأنه هو الوضع،
+
+307
+00:26:19,830 --> 00:26:23,170
+هذه المفهومة هي مفهومة، وهي مفهومة مصطلح، نهار
+
+308
+00:26:23,170 --> 00:26:30,150
+أخر، تفضلي أن تقول هذا، إنه جدًا غريب، موضوع
+
+309
+00:26:30,150 --> 00:26:36,810
+ومصطلح، أين الموضوع ومصطلح؟ يجب أن تقول إنهم
+
+310
+00:26:36,810 --> 00:26:47,660
+مصطلحيناها where is the subject؟ okay
+
+311
+00:26:47,660 --> 00:26:51,180
+now
+
+312
+00:26:51,180 --> 00:26:56,900
+where is the clause؟ where is the clause؟ okay
+
+313
+00:26:56,900 --> 00:26:59,160
+thank you and where is the subject of the
+
+314
+00:26:59,160 --> 00:27:02,100
+sentence؟ that you should say this is a is very
+
+315
+00:27:02,100 --> 00:27:06,130
+strange where is the subject of the sentence؟Okay
+
+316
+00:27:06,130 --> 00:27:15,650
+read it read it again okay it
+
+317
+00:27:15,650 --> 00:27:19,430
+is the subject of the sentence good and because
+
+318
+00:27:19,430 --> 00:27:22,930
+this clause is used as the subject of the sentence
+
+319
+00:27:22,930 --> 00:27:27,270
+it is what it is a noun clause okay so what are
+
+320
+00:27:27,270 --> 00:27:31,440
+noun clausesnoun clauses also it contains by
+
+321
+00:27:31,440 --> 00:27:39,180
+subject and predicate and maybe it should be
+
+322
+00:27:39,180 --> 00:27:44,920
+object or subject so thank you very much a noun
+
+323
+00:27:44,920 --> 00:27:50,040
+clause is you know it contains a subject and a
+
+324
+00:27:50,040 --> 00:27:54,320
+predicate as all the other clauses and it is the
+
+325
+00:27:54,320 --> 00:27:58,410
+subject or the object of the sentenceأتمنى أنه
+
+326
+00:27:58,410 --> 00:28:05,590
+صحيح. الآن، انظر إلى التعليم. نعم، أنت هناك في
+
+327
+00:28:05,590 --> 00:28:06,070
+الخلف.
+
+328
+00:28:09,170 --> 00:28:10,830
+ابدأ الانتقال.
+
+329
+00:28:19,090 --> 00:28:25,930
+نعم. الآن، أنا أتسأل .. انت ماتت. أنا أتسأل ماذا؟
+
+330
+00:28:28,070 --> 00:28:34,090
+Okay, good. What's that? Very good. One. It is one
+
+331
+00:28:34,090 --> 00:28:37,630
+clause. Thank you. Your neighbor. Yeah.
+
+332
+00:28:43,530 --> 00:28:49,170
+Okay. I feel what? Just a minute. Just a minute. I
+
+333
+00:28:49,170 --> 00:28:52,810
+feel what? What's the answer to what? Okay. So
+
+334
+00:28:52,810 --> 00:28:57,510
+where is the clause?أين ذلك؟ اقرأه مرة أخرى، اقرأ
+
+335
+00:28:57,510 --> 00:29:02,450
+الكلمة فقط هذا انا
+
+336
+00:29:02,450 --> 00:29:07,130
+سأخسر، شكرا، جيد، إنها كلمة كلمة فقط لأنها موضوع
+
+337
+00:29:07,130 --> 00:29:13,630
+الكلمة، الواحد خلفك يا سمين خلفك
+
+338
+00:29:13,630 --> 00:29:21,870
+هذا ما قلتيه يا سمين، هذا ما قلتيهOkay that you
+
+339
+00:29:21,870 --> 00:29:26,830
+have come it pleases what it pleases me that you
+
+340
+00:29:26,830 --> 00:29:32,930
+have come why it is a noun clause why it is a noun
+
+341
+00:29:32,930 --> 00:29:38,030
+clause it is the subject of the sentence it is the
+
+342
+00:29:38,030 --> 00:29:40,770
+subject of the sentence thank you next one
+
+343
+00:29:48,440 --> 00:29:59,460
+وكان يجيب علينا أن نعود للمنزل ويجيب
+
+344
+00:29:59,460 --> 00:30:04,420
+علينا أن نعود للمنزل ويجيب علينا أن نعود للمنزل
+
+345
+00:30:04,420 --> 00:30:07,560
+ويجيب علينا أن نعود للمنزل
+
+346
+00:30:11,060 --> 00:30:15,560
+this is this is an exercise okay it contains
+
+347
+00:30:15,560 --> 00:30:19,200
+different sentences different phrases and
+
+348
+00:30:19,200 --> 00:30:25,660
+different clauses underline read the underline not
+
+349
+00:30:25,660 --> 00:30:31,010
+now not now this is homeworkOkay؟ And read the
+
+350
+00:30:31,010 --> 00:30:34,450
+underlined group of words carefully. Decide
+
+351
+00:30:34,450 --> 00:30:38,310
+whether it is a phrase or a clause. And what type
+
+352
+00:30:38,310 --> 00:30:40,750
+of a phrase or what type of a clause. Then tick
+
+353
+00:30:40,750 --> 00:30:44,910
+the right box there. Is that okay? Thank you very
+
+354
+00:30:44,910 --> 00:30:46,470
+much and see you on Saturday.
+
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/_edjjUoOcpA_raw.srt b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/_edjjUoOcpA_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..1d1c595d18b957c48f92a415f56bed9669cb0a7b
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/_edjjUoOcpA_raw.srt
@@ -0,0 +1,1436 @@
+1
+00:00:21,180 --> 00:00:26,140
+Good morning to you all. How are you today? Last
+
+2
+00:00:26,140 --> 00:00:28,360
+time we started talking about the phrases
+
+3
+00:00:45,290 --> 00:00:53,190
+the underlined words yes please a finite verb yes
+
+4
+00:00:53,190 --> 00:00:57,550
+a phrase what type of phrase adjective phrase
+
+5
+00:00:57,550 --> 00:01:02,200
+adjective phrase very good becauseit describes the
+
+6
+00:01:02,200 --> 00:01:05,780
+noun thank you very much and what would you like
+
+7
+00:01:05,780 --> 00:01:09,140
+to say about the other sentence yes please don't
+
+8
+00:01:09,140 --> 00:01:12,760
+talk like that without phrases and verbs because
+
+9
+00:01:12,760 --> 00:01:17,960
+they are describing very good don't talk how like
+
+10
+00:01:17,960 --> 00:01:21,480
+that okay thank you very much any question about
+
+11
+00:01:21,480 --> 00:01:22,500
+the brief just material
+
+12
+00:01:38,240 --> 00:01:41,900
+الأن، انظروا إلى الأمثلة، من يرغب في قراءة الأولة
+
+13
+00:01:41,900 --> 00:01:47,040
+من الأمثلة؟ نعم، بفضل الله. He wants to go home.
+
+14
+00:01:47,160 --> 00:01:52,660
+He wants what؟ He wants what؟ To go home. He wants
+
+15
+00:01:52,660 --> 00:01:54,960
+to go home. Where is the object؟
+
+16
+00:01:57,310 --> 00:02:04,130
+الأن إسمع ، الوضع عادةً مجرد إجابة لماذا أكلت في
+
+17
+00:02:04,130 --> 00:02:09,490
+فيلم؟ ماذا أكلت؟ رأيت فيلم؟ ماذا رأيت؟ قرأت كتابة؟
+
+18
+00:02:09,490 --> 00:02:16,430
+ماذا قرأت؟ الوضع عادةً مجرد إجابة لماذا؟ هو يريد
+
+19
+00:02:16,430 --> 00:02:20,770
+ماذا؟ الذهاب للمنزل ، شكراً ، لذلك أين هو الوضع
+
+20
+00:02:20,770 --> 00:02:28,980
+مجدداً؟ الذهاب للمنزل ، الوضع دائماً مسمىالوضع
+
+21
+00:02:28,980 --> 00:02:33,800
+دائمًا نوعًا. تذكرين عندما كنا نتكلم عن الفرازات
+
+22
+00:02:33,800 --> 00:02:38,610
+التجاربية و الفرازات التجاربية، قالناit is an
+
+23
+00:02:38,610 --> 00:02:43,410
+adjective phrase because it acts it behaves as an
+
+24
+00:02:43,410 --> 00:02:46,950
+adjective it is an adverb phrase because it
+
+25
+00:02:46,950 --> 00:02:52,830
+behaves as an adverb but this is a noun phrase is
+
+26
+00:02:52,830 --> 00:02:55,970
+used as the noun as the object the object is the
+
+27
+00:02:55,970 --> 00:02:59,990
+noun so now it is the noun it is the object so the
+
+28
+00:02:59,990 --> 00:03:03,310
+phrase itself is the object look at the other
+
+29
+00:03:03,310 --> 00:03:08,730
+sentence yes ياسمينأنا حاولت أن أحصل على الوضع
+
+30
+00:03:08,730 --> 00:03:14,250
+صحيح حاولت ماذا؟ حاولت أن أحصل على الوضع صحيح حسنا
+
+31
+00:03:14,250 --> 00:03:19,010
+شكرا اذا أين الموضوع نفين؟ لأحصل على الوضع صحيح
+
+32
+00:03:19,010 --> 00:03:26,150
+شكرا جدا اقرأ الاخر حنين الوضع صحيح الأن أين
+
+33
+00:03:26,150 --> 00:03:34,510
+الموضوع؟ عندما أقول هذا هو مهتمتي أين الموضوع؟مرة
+
+34
+00:03:34,510 --> 00:03:41,330
+أخرى، فقط لحظة، انتظر، اعطيها فرصة اجابة ايه
+
+35
+00:03:41,330 --> 00:03:43,210
+الموضوع؟ اجابة ايه الموضوع؟ اجابة ايه الموضوع؟
+
+36
+00:03:43,210 --> 00:03:44,210
+اجابة ايه الموضوع؟ اجابة ايه الموضوع؟ اجابة ايه
+
+37
+00:03:44,210 --> 00:03:45,450
+الموضوع؟ اجابة ايه الموضوع؟ اجابة ايه الموضوع؟
+
+38
+00:03:45,450 --> 00:03:46,110
+اجابة ايه الموضوع؟ اجابة ايه الموضوع؟ اجابة ايه
+
+39
+00:03:46,110 --> 00:03:46,110
+الموضوع؟ اجابة ايه الموضوع؟ اجابة ايه الموضوع؟
+
+40
+00:03:46,110 --> 00:03:50,250
+اجابة ايه الموضوع؟ اجابة
+
+41
+00:03:50,250 --> 00:03:56,150
+ايه الموضوع؟ اجابة ايه الموضوع؟ اجابة ا
+
+42
+00:03:59,460 --> 00:04:04,280
+we call it a noun phrase because it acts like the
+
+43
+00:04:04,280 --> 00:04:08,140
+subject or object it is the subject it is the
+
+44
+00:04:08,140 --> 00:04:11,620
+subject or the object okay and the subjects and
+
+45
+00:04:11,620 --> 00:04:16,140
+the objects are usually nouns are always nouns we
+
+46
+00:04:16,140 --> 00:04:19,680
+cannot use other words as subjects or as objects
+
+47
+00:04:19,680 --> 00:04:23,900
+they are usually nouns so a noun phrase is used as
+
+48
+00:04:23,900 --> 00:04:27,540
+the object or as the subject of the sentence is
+
+49
+00:04:27,540 --> 00:04:33,600
+that okayالأن، انظروا لهذا التعليم، رقم واحد، نور،
+
+50
+00:04:33,600 --> 00:04:36,600
+هل يمكنك أن تقرأ؟ اختار الفرازات الموجودة في
+
+51
+00:04:36,600 --> 00:04:39,360
+التعليقات التالية، نعم، أين هي الفرازات الموجودة؟
+
+52
+00:04:39,360 --> 00:04:45,480
+جيد، أبوه أراد أن يتحدث للعلمان الداهيد، نعم، أبوه
+
+53
+00:04:45,480 --> 00:04:51,200
+أراد، نعم، أين الفرازة؟ تتحدث، تتحدث، تتحدث،
+
+54
+00:04:51,200 --> 00:04:52,220
+تتحدث، تتحدث، تتحدث، تتحدث، تتحدث، تتحدث، تتحدث،
+
+55
+00:04:52,220 --> 00:04:52,420
+تتحدث، تتحدث، تتحدث، تتحدث، تتحدث، تتحدث، تتحدث،
+
+56
+00:04:52,420 --> 00:04:55,420
+تتحدث، تتحدث، تتحدث، تتحدث، تتحدث
+
+57
+00:04:58,940 --> 00:05:02,300
+to speak to the headmaster so where is the phrase
+
+58
+00:05:02,300 --> 00:05:07,540
+again to speak this is the object okay this is the
+
+59
+00:05:07,540 --> 00:05:12,820
+object why it is the object okay sorry if this is
+
+60
+00:05:12,820 --> 00:05:15,640
+a noun phrase why it is a noun phrase because it
+
+61
+00:05:15,640 --> 00:05:19,020
+is the object of the sentence thank you very much
+
+62
+00:05:19,020 --> 00:05:25,560
+good yes please next one to manage my studentsI
+
+63
+00:05:25,560 --> 00:05:29,540
+dislike what very good this is the noun phrase
+
+64
+00:05:29,540 --> 00:05:34,640
+thank you very much good next one yes please he
+
+65
+00:05:34,640 --> 00:05:38,100
+denies stealing the money he denies what stealing
+
+66
+00:05:38,100 --> 00:05:42,240
+the money okay stealing the money thank you yeah
+
+67
+00:05:42,240 --> 00:05:48,360
+have you ever tried climbing a mountain climbing a
+
+68
+00:05:48,360 --> 00:05:53,660
+mountain very good tried what climbing a mountain
+
+69
+00:05:53,660 --> 00:05:56,820
+thank you very muchHorses prefer living in dark
+
+70
+00:05:56,820 --> 00:06:00,380
+stables Yes
+
+71
+00:06:00,380 --> 00:06:05,080
+prefer what? Living in okay dark stables good Now
+
+72
+00:06:05,080 --> 00:06:10,160
+these are the answers you can look at them What
+
+73
+00:06:10,160 --> 00:06:14,860
+about the prepositional phrase?الان تحدثنا عن
+
+74
+00:06:14,860 --> 00:06:20,200
+الفرصة التجارية والفرصة التجارية والفرصة التجارية
+
+75
+00:06:20,200 --> 00:06:22,820
+والفرصة التجارية والفرصة التجارية والفرصة التجارية
+
+76
+00:06:22,820 --> 00:06:25,000
+والفرصة التجارية والفرصة التجارية والفرصة التجارية
+
+77
+00:06:25,000 --> 00:06:25,460
+والفرصة التجارية والفرصة التجارية والفرصة التجارية
+
+78
+00:06:25,460 --> 00:06:25,620
+والفرصة التجارية والفرصة التجارية والفرصة التجارية
+
+79
+00:06:25,620 --> 00:06:29,820
+والفرصة التجارية والفرصة التجارية والفرصة التجارية
+
+80
+00:06:29,820 --> 00:06:34,160
+والفرصة التجارية والفرصة التجارية والفرصة التجارية
+
+81
+00:06:34,160 --> 00:06:38,680
+والفرصة التجارية والفرصة التجارية والفرصة التجارية
+
+82
+00:06:38,680 --> 00:06:47,710
+والفانا و نيكولاس how؟ now let's see if you look
+
+83
+00:06:47,710 --> 00:06:51,670
+at this example when I say at home I have
+
+84
+00:06:51,670 --> 00:06:57,310
+preposition and now in time preposition and now
+
+85
+00:06:57,310 --> 00:07:06,570
+okay from sue preposition and with me for youby
+
+86
+00:07:06,570 --> 00:07:15,930
+singing by sleeping by eating okay this is gerund
+
+87
+00:07:15,930 --> 00:07:20,690
+now as you see they are prepositional phrases they
+
+88
+00:07:20,690 --> 00:07:25,430
+are made of a preposition and a noun a pronoun or
+
+89
+00:07:25,430 --> 00:07:33,610
+a gerund now look about what we needعن ما نحتاجه ،
+
+90
+00:07:33,610 --> 00:07:39,190
+لدينا مصطلح ومصطلح نوني مصطلح نوني مصطلح نوني
+
+91
+00:07:39,190 --> 00:07:43,410
+مصطلح نوني مصطلح نوني مصطلح نوني مصطلح نوني مصطلح
+
+92
+00:07:43,410 --> 00:07:43,590
+نوني مصطلح نوني مصطلح نوني مصطلح نوني مصطلح نوني
+
+93
+00:07:43,590 --> 00:07:43,770
+مصطلح نوني مصطلح نوني مصطلح نوني مصطلح نوني مصطلح
+
+94
+00:07:43,770 --> 00:07:44,530
+نوني مصطلح نوني مصطلح نوني مصطلح نوني مصطلح نوني
+
+95
+00:07:44,530 --> 00:07:49,990
+مصطلح نوني مصطلح نوني مصطلح نوني
+
+96
+00:07:49,990 --> 00:07:59,130
+مصطلح نوني مصطلح نون
+
+97
+00:07:59,500 --> 00:08:06,040
+أموديفير is a specifier it specifies the noun when
+
+98
+00:08:06,040 --> 00:08:10,800
+I say grandmother it can be any grandmother when I
+
+99
+00:08:10,800 --> 00:08:17,500
+say your grandmother it's okay my grandmother it
+
+100
+00:08:17,500 --> 00:08:22,480
+made the noun specific so we use what a
+
+101
+00:08:22,480 --> 00:08:28,140
+preposition a modifier and a noun under the warm
+
+102
+00:08:28,140 --> 00:08:34,960
+blanketagain we use a preposition and modifiers
+
+103
+00:08:34,960 --> 00:08:43,320
+okay and now good now we know what is a
+
+104
+00:08:43,320 --> 00:08:48,200
+prepositional phrase at least it is made up of a
+
+105
+00:08:48,200 --> 00:08:49,340
+preposition and
+
+106
+00:08:52,020 --> 00:08:57,460
+pronoun or gerund or pronounic clause it can be
+
+107
+00:08:57,460 --> 00:09:01,800
+expanded we can use also modifiers in a noun in a
+
+108
+00:09:01,800 --> 00:09:05,160
+prepositional phrase a prepositional phrase
+
+109
+00:09:05,160 --> 00:09:12,180
+usually behaves as an adjective or as an adverb
+
+110
+00:09:12,860 --> 00:09:17,100
+Okay, so it functions usually as what? An
+
+111
+00:09:17,100 --> 00:09:20,880
+adjective or an adverb? How can I distinguish
+
+112
+00:09:20,880 --> 00:09:24,360
+between this and that? If you look at this example
+
+113
+00:09:24,360 --> 00:09:28,600
+Yeah, who wants to read the example? Yes please
+
+114
+00:09:28,600 --> 00:09:33,440
+دعا The book on the bathroom floor is stolen from
+
+115
+00:09:33,440 --> 00:09:36,800
+a shower stand Thank you, now the book on which
+
+116
+00:09:36,800 --> 00:09:42,900
+one?which one so it answers the question which one
+
+117
+00:09:42,900 --> 00:09:46,180
+if it answers the question which one it is an
+
+118
+00:09:46,180 --> 00:09:50,200
+adjective phrase okay it functions as an adjective
+
+119
+00:09:50,200 --> 00:09:55,460
+phrase okay so a prepositional phrase when answers
+
+120
+00:09:55,460 --> 00:10:00,840
+the question which one it functions asan adjective
+
+121
+00:10:00,840 --> 00:10:04,200
+phrase، good، now which book .. now look at the
+
+122
+00:10:04,200 --> 00:10:07,220
+other one, who can read the example؟ yes خديجة؟
+
+123
+00:10:07,220 --> 00:10:10,040
+the sweet potatoes in the vegetable bin are green
+
+124
+00:10:10,040 --> 00:10:15,490
+with mold okay which ones?Which ones? So this
+
+125
+00:10:15,490 --> 00:10:19,510
+prepositional phrase functions as what? An
+
+126
+00:10:19,510 --> 00:10:23,570
+adjective phrase. Now what about the prepositional
+
+127
+00:10:23,570 --> 00:10:27,330
+phrase when it functions as an adverb? When it
+
+128
+00:10:27,330 --> 00:10:31,910
+functions as an adverb, you know, adverb phrases
+
+129
+00:10:31,910 --> 00:10:35,870
+and clauses usually answer questions like what,
+
+130
+00:10:36,510 --> 00:10:45,450
+like why, how, when, where, okay?Now فادي يا who
+
+131
+00:10:45,450 --> 00:10:52,410
+wants to read the example حنين okay
+
+132
+00:10:52,410 --> 00:10:54,950
+فادي is stiff from yesterday's long football
+
+133
+00:10:54,950 --> 00:10:58,490
+practice thank you how did he get stiff from
+
+134
+00:10:58,490 --> 00:11:03,250
+yesterday so it answers what how it answers how so
+
+135
+00:11:03,250 --> 00:11:07,890
+it functions as adverb very good read the other
+
+136
+00:11:07,890 --> 00:11:08,650
+one please
+
+137
+00:11:14,490 --> 00:11:21,790
+Okay when did jihad do this? before class okay so
+
+138
+00:11:21,790 --> 00:11:27,250
+before class this is a prepositional phrase it
+
+139
+00:11:27,250 --> 00:11:33,570
+acts or functions as thank you and finally finally
+
+140
+00:11:33,570 --> 00:11:34,510
+yes please read
+
+141
+00:11:41,510 --> 00:11:47,750
+Okay where did we try the food okay so again this
+
+142
+00:11:47,750 --> 00:11:51,230
+is what what would you say about this point yes
+
+143
+00:11:51,230 --> 00:11:58,010
+what would you say a propositional phrase adverb
+
+144
+00:11:58,010 --> 00:12:04,220
+okay thank you very much good nowلنعود إلى
+
+145
+00:12:04,220 --> 00:12:09,840
+الاختصارات حسنا؟ لذلك تحدثنا عن أربع نوع من
+
+146
+00:12:09,840 --> 00:12:18,760
+الفرازين لنعود إلى الاختصارات أولا ماهي اختصار؟
+
+147
+00:12:18,760 --> 00:12:26,340
+قلنا ان الفراز مجموعة من كلمات متعلقة بدون كلمة
+
+148
+00:12:26,340 --> 00:12:34,040
+معينة بدون ماهي كلمة؟ كلمة معينة و بدون؟Okay of
+
+149
+00:12:34,040 --> 00:12:38,760
+course, no verb, no subject, no complete sense. So
+
+150
+00:12:38,760 --> 00:12:44,780
+if this group of words contains a finite verb, has
+
+151
+00:12:44,780 --> 00:12:48,860
+a subject and a predicate, first of all, what is
+
+152
+00:12:48,860 --> 00:12:50,880
+the subject and what is the predicate? Who can
+
+153
+00:12:50,880 --> 00:12:51,680
+give me a sentence?
+
+154
+00:12:54,800 --> 00:12:56,080
+Give me a sentence
+
+155
+00:13:02,360 --> 00:13:07,060
+again give me any sentence I bought a red shirt I
+
+156
+00:13:07,060 --> 00:13:19,680
+bought a red shirt where is the subject I now
+
+157
+00:13:19,680 --> 00:13:23,220
+everything said about the subject is called a
+
+158
+00:13:23,220 --> 00:13:28,280
+predicate everything said about the subject is
+
+159
+00:13:28,280 --> 00:13:35,800
+called what? predicateالقصة تحتوي على أساسين أساسي
+
+160
+00:13:35,800 --> 00:13:44,240
+و مجلس ومجلس ومجلس ومجلس ومجلس ومجلس ومجلس ومجلس
+
+161
+00:13:44,240 --> 00:13:46,200
+ومجلس ومجلس ومجلس ومجلس ومجلس ومجلس ومجلس ومجلس
+
+162
+00:13:46,200 --> 00:13:50,340
+ومجلس ومجلس ومجلس ومجلس ومجلس ومجلس ومجلس
+
+163
+00:14:00,420 --> 00:14:04,120
+I bought a bag okay tell me about where is the
+
+164
+00:14:04,120 --> 00:14:08,600
+subject and the predicate I is a subject and
+
+165
+00:14:08,600 --> 00:14:12,320
+bought a bag is a predicate thank you the weather
+
+166
+00:14:12,320 --> 00:14:16,260
+is getting very cold the weather is getting very
+
+167
+00:14:16,260 --> 00:14:22,880
+cold yeah subject and it's getting very cold is
+
+168
+00:14:22,880 --> 00:14:28,700
+the predicate thank you now lookhe has a chain
+
+169
+00:14:28,700 --> 00:14:34,300
+which
+
+170
+00:14:34,300 --> 00:14:41,160
+is made of gold it is made of
+
+171
+00:14:41,160 --> 00:14:45,060
+gold look at the underlying group of words it has
+
+172
+00:14:45,060 --> 00:14:48,860
+a subject and it has a predicate
+
+173
+00:14:52,380 --> 00:14:57,700
+هل يعطيك مفهوم كام؟ نعم، نعم، نعم، نعم، نعم، نعم،
+
+174
+00:14:57,700 --> 00:14:58,640
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+175
+00:14:58,640 --> 00:15:00,700
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+176
+00:15:00,700 --> 00:15:01,500
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+177
+00:15:01,500 --> 00:15:03,460
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+178
+00:15:03,460 --> 00:15:03,940
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+179
+00:15:03,940 --> 00:15:09,360
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+180
+00:15:09,360 --> 00:15:15,540
+نعم، نعم، نعم، نعم، ن
+
+181
+00:15:18,640 --> 00:15:22,780
+الان دعونا نرى، هذه المجموعة من الكلمات تحتوي على
+
+182
+00:15:22,780 --> 00:15:27,300
+موضوع و مصطلح و بالطبع المصطلح يحتوي على كلمة
+
+183
+00:15:27,300 --> 00:15:32,600
+معينة، لديها كلمة معينة، كلمة التي تحتوي على مصطلح
+
+184
+00:15:32,600 --> 00:15:36,020
+مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح
+
+185
+00:15:36,020 --> 00:15:36,500
+مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح
+
+186
+00:15:36,500 --> 00:15:37,380
+مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح
+
+187
+00:15:37,380 --> 00:15:41,720
+مصطلح مصطلح مصطلح مصطلح
+
+188
+00:15:41,720 --> 00:15:44,960
+مصطلح
+
+189
+00:15:44,960 --> 00:15:55,200
+موما هو فرصة مفتوحة؟ ما هو؟ هو الشخص اللي يتحدث
+
+190
+00:15:55,200 --> 00:16:04,110
+عننا، ومفتوحة مفتوحة هي الشخص الليماذا يسمى الفرصة
+
+191
+00:16:04,110 --> 00:16:10,550
+الاضافية؟ هي التي تسمي الفرصة وهي تسمي الفرصة، جيد
+
+192
+00:16:10,550 --> 00:16:15,470
+جدا، ويعادة تجيب على أسئلة مثل أين، أين، كيف،
+
+193
+00:16:15,470 --> 00:16:17,770
+وكذلك، وكذلك، وكذلك، وكذلك، وكذا، وكذا، وكذا،
+
+194
+00:16:17,770 --> 00:16:18,410
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا،
+
+195
+00:16:18,410 --> 00:16:20,370
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا،
+
+196
+00:16:20,370 --> 00:16:20,890
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا،
+
+197
+00:16:20,890 --> 00:16:21,510
+وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، وكذا، و
+
+198
+00:16:21,700 --> 00:16:26,740
+الأن، ماذا عن الفرسة الاسمية؟ انها الوضع أو الوضع
+
+199
+00:16:26,740 --> 00:16:31,700
+و الوضع أو الوضع و القرصة الاسمية تستخدم أيضًا
+
+200
+00:16:31,700 --> 00:16:38,280
+كوضع و وضع. حسنًا؟ حسنًا، حسنًا، حسنًا، حسنًا،
+
+201
+00:16:38,280 --> 00:16:38,280
+حسنًا، حسنًا، حسنًا، حسنًا، حسنًا، حسنًا، حسنًا،
+
+202
+00:16:38,280 --> 00:16:38,380
+حسنًا، حسنًا، حسنًا، حسنًا، حسنًا، حسنًا، حسنًا،
+
+203
+00:16:38,380 --> 00:16:48,100
+حسنًا، حسنًا، حسنًا، حسنًا، حسنًا، حسنًا، حسنًا،
+
+204
+00:16:48,100 --> 00:16:53,250
+حسنًOkay, there is a subject and a predicate.
+
+205
+00:16:53,330 --> 00:16:56,050
+Good. So, the underlined group of words.
+
+206
+00:16:59,430 --> 00:17:02,590
+Adverbic clause. Very good. Thank you. You miss it
+
+207
+00:17:02,590 --> 00:17:08,610
+where? Where? It qualifies the verb, right? You
+
+208
+00:17:08,610 --> 00:17:12,790
+miss it where? Wherever you like. Thank you very
+
+209
+00:17:12,790 --> 00:17:17,630
+much. Read the other one please. Yes, you. Yes.
+
+210
+00:17:18,630 --> 00:17:24,250
+Number two.he behaves as one might expect him to
+
+211
+00:17:24,250 --> 00:17:27,830
+do thank you yes who wants to comment on this
+
+212
+00:17:27,830 --> 00:17:32,990
+clause how
+
+213
+00:17:32,990 --> 00:17:40,330
+he behaves how as one might expect him to do okay
+
+214
+00:17:40,330 --> 00:17:46,630
+he behaves how okay next one pleaseif you eat too
+
+215
+00:17:46,630 --> 00:17:50,470
+much you will be ill if you eat too much this is
+
+216
+00:17:50,470 --> 00:17:55,370
+conditional okay okay
+
+217
+00:17:55,370 --> 00:17:59,550
+thank you when you eat too much you will be ill
+
+218
+00:17:59,550 --> 00:18:03,530
+okay now what would you say about adverbic clauses
+
+219
+00:18:03,530 --> 00:18:09,360
+tell me it's your turn to explain go onو ماذا
+
+220
+00:18:09,360 --> 00:18:14,420
+ستقول عن اكتشاف الكلمات الاساسي هي نادا ذهبت تعمل
+
+221
+00:18:14,420 --> 00:18:20,340
+عمل الكلمة تعمل عمل الكلمة تعمل عمل الكلمة تعمل
+
+222
+00:18:20,340 --> 00:18:20,560
+عمل الكلمة تعمل عمل الكلمة تعمل عمل الكلمة تعمل
+
+223
+00:18:20,560 --> 00:18:22,840
+عمل الكلمة تعمل عمل الكلمة تعمل عمل الكلمة تعمل
+
+224
+00:18:22,840 --> 00:18:25,820
+عمل الكلمة تعمل عمل الكلمة تعمل عمل الكلمة تعمل
+
+225
+00:18:25,820 --> 00:18:26,700
+عمل الكلمة تعمل عمل الكلمة تعمل عمل الكلمة تعمل
+
+226
+00:18:26,700 --> 00:18:26,700
+عمل الكلمة تعمل عمل الكلمة تعمل عمل الكلمة تعمل
+
+227
+00:18:26,700 --> 00:18:26,700
+عمل الكلمة تعمل عمل الكلمة تعمل عمل الكلمة تعمل
+
+228
+00:18:26,700 --> 00:18:34,540
+عمل الكلمة تعمل عمل الكلمة تعمل عمل الكلمة تعمل ع
+
+229
+00:18:41,220 --> 00:18:55,660
+بسبب أنك فعلت هذا سأعذبك لأنك
+
+230
+00:18:55,660 --> 00:18:59,460
+فعلت هذا لأنك فعلت هذا
+
+231
+00:19:07,700 --> 00:19:14,000
+فضلي number two why
+
+232
+00:19:14,000 --> 00:19:18,780
+why did I speak to his brother no no no she this
+
+233
+00:19:18,780 --> 00:19:23,460
+is for her yeah go on where is the adverbic clause
+
+234
+00:19:23,460 --> 00:19:25,380
+ask yourself why
+
+235
+00:19:29,590 --> 00:19:34,590
+لماذا كنت اتكلم مع أخيه؟ الان ماذا يعني بإنجليزي؟
+
+236
+00:19:34,590 --> 00:19:37,490
+ماذا يعني از؟ بسبب .. بسبب .. بسبب .. بسبب .. بسبب
+
+237
+00:19:37,490 --> 00:19:39,830
+.. بسبب .. بسبب .. بسبب .. بسبب .. بسبب .. بسبب ..
+
+238
+00:19:39,830 --> 00:19:41,810
+بسبب .. بسبب .. بسبب .. بسبب .. بسبب .. بسبب ..
+
+239
+00:19:41,810 --> 00:19:42,030
+بسبب .. بسبب .. بسبب .. بسبب .. بسبب .. بسبب ..
+
+240
+00:19:42,030 --> 00:19:42,210
+بسبب .. بسبب .. بسبب .. بسبب .. بسبب .. بسبب ..
+
+241
+00:19:42,210 --> 00:19:42,210
+بسبب .. بسبب .. بسبب .. بسبب .. بسبب .. بسبب ..
+
+242
+00:19:42,210 --> 00:19:45,450
+بسبب .. بسبب .. بسبب .. بسبب .. بسبب .. بسبب ..
+
+243
+00:19:45,450 --> 00:19:54,110
+بسبب .. بسبب .. بسبب .. بسبب .. بسبب .. بسب
+
+244
+00:19:58,940 --> 00:20:11,040
+هل انت تنتظر حتى ارجع ؟ حتى ارجع ؟ حتى ارجع ؟ حتى
+
+245
+00:20:11,040 --> 00:20:19,980
+ارجع ؟ حتى ارجع ؟ حتى ارجع ؟ حتى ارجع ؟ حتى ارجع ؟
+
+246
+00:20:21,820 --> 00:20:27,720
+Okay when .. just as
+
+247
+00:20:27,720 --> 00:20:32,980
+he entered the room okay now when did the clock
+
+248
+00:20:32,980 --> 00:20:37,320
+what struck if I begin with dead what shall I say
+
+249
+00:20:37,320 --> 00:20:43,960
+one speaker when did the clock strike strike take
+
+250
+00:20:43,960 --> 00:20:48,100
+care okay when did the clock strike any question
+
+251
+00:20:48,100 --> 00:20:49,120
+on this exercise
+
+252
+00:20:55,670 --> 00:21:03,170
+adjective clauses adjective clauses okay now
+
+253
+00:21:03,170 --> 00:21:09,510
+number one read please say a little lamb a little
+
+254
+00:21:09,510 --> 00:21:16,470
+cat okay you know the lamb yes okay good whose
+
+255
+00:21:16,470 --> 00:21:17,030
+fleece
+
+256
+00:21:19,930 --> 00:21:25,930
+Okay now the underlined words whose fleece was as
+
+257
+00:21:25,930 --> 00:21:28,870
+white as snow yes what would you comment what
+
+258
+00:21:28,870 --> 00:21:30,710
+would you say about this group of words
+
+259
+00:21:35,690 --> 00:21:38,470
+it is adjective clause very good thank you why it
+
+260
+00:21:38,470 --> 00:21:41,470
+is an adjective clause yes please it has a subject
+
+261
+00:21:41,470 --> 00:21:47,190
+and a precedent and it behaves as an adjective
+
+262
+00:21:47,190 --> 00:21:51,450
+okay thank you behaves describes the noun نفين
+
+263
+00:21:51,450 --> 00:21:54,750
+number two the letter from money which was badly
+
+264
+00:21:54,750 --> 00:21:59,030
+needed okay what type of money okay money it
+
+265
+00:21:59,030 --> 00:22:03,250
+describes what money which was badly needed yes go
+
+266
+00:22:03,250 --> 00:22:04,490
+on نفين what would you say
+
+267
+00:22:07,350 --> 00:22:13,670
+عن الكلمات المصطلحة المال؟ حسنا، إنها كلمة مصطلحة
+
+268
+00:22:13,670 --> 00:22:15,010
+مصطلحة مصطلحة مصطلحة مصطلحة مصطلحة مصطلحة مصطلحة
+
+269
+00:22:15,010 --> 00:22:17,110
+مصطلحة مصطلحة مصطلحة مصطلحة مصطلحة مصطلحة مصطلحة
+
+270
+00:22:17,110 --> 00:22:20,150
+مصطلحة مصطلحة مصطلحة مصطلحة مصطلحة مصطلحة مصطلحة
+
+271
+00:22:20,150 --> 00:22:27,530
+مصطلحة مصطلحة مصطلحة مصطلحة
+
+272
+00:22:33,940 --> 00:22:41,200
+yes they never fail who die in a great cause okay
+
+273
+00:22:41,200 --> 00:22:48,320
+it means people who die it describes what the noun
+
+274
+00:22:48,320 --> 00:22:51,120
+thank you so what would you say about the
+
+275
+00:22:51,120 --> 00:22:56,300
+adjective classالقصة الاجيكتيفية محتوى عن موضوع
+
+276
+00:22:56,300 --> 00:23:01,580
+ومصطلح محتوى عن موضوع ومصطلح كالقصة الاخرى قصة
+
+277
+00:23:01,580 --> 00:23:05,100
+اجيكتيفية
+
+278
+00:23:05,100 --> 00:23:14,340
+اتفضلي
+
+279
+00:23:14,340 --> 00:23:16,920
+اين هي القصة الاجيكتيفية؟
+
+280
+00:23:24,150 --> 00:23:29,010
+the house that I live in with my father and three
+
+281
+00:23:29,010 --> 00:23:34,590
+daughters the house which house please we want one
+
+282
+00:23:34,590 --> 00:23:38,930
+speaker okay one speaker don't talk together she's
+
+283
+00:23:38,930 --> 00:23:47,210
+speaking yeah she can which house that I live in
+
+284
+00:23:47,210 --> 00:23:50,350
+very good now when I say the house it can be any
+
+285
+00:23:50,350 --> 00:23:56,470
+house rightالأدجكتف أيضًا يشرح النام، أليس كذلك؟
+
+286
+00:23:56,470 --> 00:24:00,490
+الادجكتف عندما أقول فتاة، يمكن أن تكون أي فتاة،
+
+287
+00:24:00,490 --> 00:24:04,430
+أليس كذلك؟ لكن الفتاة الطويلة .. الفتاة الطويلة
+
+288
+00:24:04,430 --> 00:24:10,830
+جعلت النام محدودًا، المنزل، المنزل الذي أعيش
+
+289
+00:24:10,830 --> 00:24:19,520
+فيهthat I live in yeah thank you which goes
+
+290
+00:24:19,520 --> 00:24:22,660
+in and out with me thank you that's right thank
+
+291
+00:24:22,660 --> 00:24:30,360
+you yeah that
+
+292
+00:24:30,360 --> 00:24:34,220
+bites doesn't okay the dog now again where is the
+
+293
+00:24:34,220 --> 00:24:40,770
+adjective clausethat bites that bites okay the dog
+
+294
+00:24:40,770 --> 00:24:46,690
+that bites which dog okay thank you yes please
+
+295
+00:24:46,690 --> 00:24:50,330
+okay
+
+296
+00:24:50,330 --> 00:24:54,150
+good
+
+297
+00:24:54,150 --> 00:24:58,050
+thank you and finally yes that
+
+298
+00:25:06,890 --> 00:25:16,190
+which now which wind which wind that blows nobody
+
+299
+00:25:16,190 --> 00:25:22,570
+any good okay that blows nobody any good okay it
+
+300
+00:25:22,570 --> 00:25:28,570
+describes what the noun good now you can look at
+
+301
+00:25:28,570 --> 00:25:35,890
+the answers and finally نعني clausesالان قصة نقل
+
+302
+00:25:35,890 --> 00:25:40,960
+من يريد أن يبدأ من يريد أن يتحدث انه حان دوركI
+
+303
+00:25:40,960 --> 00:25:43,900
+expect that I shall get a prize yes what will you
+
+304
+00:25:43,900 --> 00:25:47,400
+say about this sentence that I shall get a prize
+
+305
+00:25:47,400 --> 00:25:51,880
+it had a subject and a predicate a predicate so it
+
+306
+00:25:51,880 --> 00:25:55,260
+is a clause so what type of a clause it's not a
+
+307
+00:25:55,260 --> 00:25:59,580
+clause why because it has a subject it is a ..
+
+308
+00:25:59,580 --> 00:26:04,720
+listen it is a object very good it is the object
+
+309
+00:26:04,720 --> 00:26:07,280
+where is the object of the sentence I expect what
+
+310
+00:26:08,630 --> 00:26:13,310
+أتوقع أني أحصل على فائدة، حسنًا؟ لذلك، هذا هو
+
+311
+00:26:13,310 --> 00:26:19,830
+الوضع، صحيح؟ هذا هو الوضع، بالطبع، لأنه هو الوضع،
+
+312
+00:26:19,830 --> 00:26:23,170
+هذه المفهومة هي مفهومة، وهي مفهومة مصطلح، نهار
+
+313
+00:26:23,170 --> 00:26:30,150
+أخر، تفضلي أن تقول هذا، إنه جدًا غريب، موضوع
+
+314
+00:26:30,150 --> 00:26:36,810
+ومصطلح، أين الموضوع ومصطلح؟ يجب أن تقول إنهم
+
+315
+00:26:36,810 --> 00:26:47,660
+مصطلحيناها where is the subject؟ okay
+
+316
+00:26:47,660 --> 00:26:51,180
+now
+
+317
+00:26:51,180 --> 00:26:56,900
+where is the clause؟ where is the clause؟ okay
+
+318
+00:26:56,900 --> 00:26:59,160
+thank you and where is the subject of the
+
+319
+00:26:59,160 --> 00:27:02,100
+sentence؟ that you should say this is a is very
+
+320
+00:27:02,100 --> 00:27:06,130
+strange where is the subject of the sentence؟Okay
+
+321
+00:27:06,130 --> 00:27:15,650
+read it read it again okay it
+
+322
+00:27:15,650 --> 00:27:19,430
+is the subject of the sentence good and because
+
+323
+00:27:19,430 --> 00:27:22,930
+this clause is used as the subject of the sentence
+
+324
+00:27:22,930 --> 00:27:27,270
+it is what it is a noun clause okay so what are
+
+325
+00:27:27,270 --> 00:27:31,440
+noun clausesnoun clauses also it contains by
+
+326
+00:27:31,440 --> 00:27:39,180
+subject and predicate and maybe it should be
+
+327
+00:27:39,180 --> 00:27:44,920
+object or subject so thank you very much a noun
+
+328
+00:27:44,920 --> 00:27:50,040
+clause is you know it contains a subject and a
+
+329
+00:27:50,040 --> 00:27:54,320
+predicate as all the other clauses and it is the
+
+330
+00:27:54,320 --> 00:27:58,410
+subject or the object of the sentenceأتمنى أنه
+
+331
+00:27:58,410 --> 00:28:05,590
+صحيح. الآن، انظر إلى التعليم. نعم، أنت هناك في
+
+332
+00:28:05,590 --> 00:28:06,070
+الخلف.
+
+333
+00:28:09,170 --> 00:28:10,830
+ابدأ الانتقال.
+
+334
+00:28:19,090 --> 00:28:25,930
+نعم. الآن، أنا أتسأل .. انت ماتت. أنا أتسأل ماذا؟
+
+335
+00:28:28,070 --> 00:28:34,090
+Okay, good. What's that? Very good. One. It is one
+
+336
+00:28:34,090 --> 00:28:37,630
+clause. Thank you. Your neighbor. Yeah.
+
+337
+00:28:43,530 --> 00:28:49,170
+Okay. I feel what? Just a minute. Just a minute. I
+
+338
+00:28:49,170 --> 00:28:52,810
+feel what? What's the answer to what? Okay. So
+
+339
+00:28:52,810 --> 00:28:57,510
+where is the clause?أين ذلك؟ اقرأه مرة أخرى، اقرأ
+
+340
+00:28:57,510 --> 00:29:02,450
+الكلمة فقط هذا انا
+
+341
+00:29:02,450 --> 00:29:07,130
+سأخسر، شكرا، جيد، إنها كلمة كلمة فقط لأنها موضوع
+
+342
+00:29:07,130 --> 00:29:13,630
+الكلمة، الواحد خلفك يا سمين خلفك
+
+343
+00:29:13,630 --> 00:29:21,870
+هذا ما قلتيه يا سمين، هذا ما قلتيهOkay that you
+
+344
+00:29:21,870 --> 00:29:26,830
+have come it pleases what it pleases me that you
+
+345
+00:29:26,830 --> 00:29:32,930
+have come why it is a noun clause why it is a noun
+
+346
+00:29:32,930 --> 00:29:38,030
+clause it is the subject of the sentence it is the
+
+347
+00:29:38,030 --> 00:29:40,770
+subject of the sentence thank you next one
+
+348
+00:29:48,440 --> 00:29:59,460
+وكان يجيب علينا أن نعود للمنزل ويجيب
+
+349
+00:29:59,460 --> 00:30:04,420
+علينا أن نعود للمنزل ويجيب علينا أن نعود للمنزل
+
+350
+00:30:04,420 --> 00:30:07,560
+ويجيب علينا أن نعود للمنزل
+
+351
+00:30:11,060 --> 00:30:15,560
+this is this is an exercise okay it contains
+
+352
+00:30:15,560 --> 00:30:19,200
+different sentences different phrases and
+
+353
+00:30:19,200 --> 00:30:25,660
+different clauses underline read the underline not
+
+354
+00:30:25,660 --> 00:30:31,010
+now not now this is homeworkOkay؟ And read the
+
+355
+00:30:31,010 --> 00:30:34,450
+underlined group of words carefully. Decide
+
+356
+00:30:34,450 --> 00:30:38,310
+whether it is a phrase or a clause. And what type
+
+357
+00:30:38,310 --> 00:30:40,750
+of a phrase or what type of a clause. Then tick
+
+358
+00:30:40,750 --> 00:30:44,910
+the right box there. Is that okay? Thank you very
+
+359
+00:30:44,910 --> 00:30:46,470
+much and see you on Saturday.
+
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/ectqOf5q5LE_postprocess.srt b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/ectqOf5q5LE_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..d76e1e5b325838c1ddd3af805e2b8bd202099fb7
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/ectqOf5q5LE_postprocess.srt
@@ -0,0 +1,1768 @@
+1
+00:00:20,970 --> 00:00:25,010
+good morning to you all how are you?
+
+2
+00:00:28,070 --> 00:00:32,150
+a lot of students are absent today what's on? hard
+
+3
+00:00:32,150 --> 00:00:37,530
+exam good luck in the exam what type of exam?
+
+4
+00:00:37,650 --> 00:00:43,950
+which exam? okay but I think this way you cannot
+
+5
+00:00:43,950 --> 00:00:48,330
+answer the problem okay
+
+6
+00:00:48,330 --> 00:00:53,850
+anyhowwhat did we talk about last time can you
+
+7
+00:00:53,850 --> 00:00:58,730
+just remind me sorry
+
+8
+00:00:58,730 --> 00:01:04,210
+count and non count nouns what's that what is
+
+9
+00:01:04,210 --> 00:01:06,790
+account can you give me an example of account noun
+
+10
+00:01:06,790 --> 00:01:14,110
+yes please sorry chair thank you this is account
+
+11
+00:01:14,110 --> 00:01:15,550
+noun non count noun
+
+12
+00:01:18,750 --> 00:01:23,970
+Gale, is it count or non-count? count, thank you,
+
+13
+00:01:24,050 --> 00:01:27,130
+gale is a count noun, thank you door,
+
+14
+00:01:29,230 --> 00:01:31,890
+thank you, I want an example of a non-count
+
+15
+00:01:31,890 --> 00:01:36,090
+furniture, thank you very much, good now what's
+
+16
+00:01:36,090 --> 00:01:40,110
+the main difference in grammar between a count
+
+17
+00:01:40,110 --> 00:01:45,210
+noun and a non-count noun? yes please
+
+18
+00:01:49,570 --> 00:01:56,870
+very good okay so the count nowaccepts the a I say
+
+19
+00:01:56,870 --> 00:02:00,310
+a book and apple okay this is called indefinite
+
+20
+00:02:00,310 --> 00:02:05,950
+article okay and also can accept the s I say box
+
+21
+00:02:05,950 --> 00:02:10,230
+apples but this cannot happen with furniture for
+
+22
+00:02:10,230 --> 00:02:14,430
+example okay now how can we use a word like
+
+23
+00:02:14,430 --> 00:02:20,710
+furniture in the singular or in the as a count
+
+24
+00:02:20,710 --> 00:02:21,070
+noun
+
+25
+00:02:28,120 --> 00:02:32,120
+very good we say a piece of furniture and and so
+
+26
+00:02:32,120 --> 00:02:36,880
+on now we want to look at some common non count
+
+27
+00:02:36,880 --> 00:02:41,640
+nouns common they are common commonly used more
+
+28
+00:02:41,640 --> 00:02:46,300
+than other nouns okay this is a list of this list
+
+29
+00:02:46,300 --> 00:02:52,230
+is a sample sample means not allWe cannot mention
+
+30
+00:02:52,230 --> 00:02:57,990
+all the non-count nouns, they are common, that are
+
+31
+00:02:57,990 --> 00:03:01,590
+commonly used as non-count nouns, many other nouns
+
+32
+00:03:01,590 --> 00:03:05,990
+can also be used as non-count nouns, many others
+
+33
+00:03:05,990 --> 00:03:08,070
+can be used as non-count nouns
+
+34
+00:03:11,650 --> 00:03:16,910
+I told you before that some non-count nouns can be
+
+35
+00:03:16,910 --> 00:03:21,270
+used as a count noun okay some non-count can be
+
+36
+00:03:21,270 --> 00:03:24,890
+used as a count noun meet for example is a non
+
+37
+00:03:24,890 --> 00:03:30,280
+-countbut sometimes I say meats the new
+
+38
+00:03:30,280 --> 00:03:33,940
+supermarket has several meats meats means what
+
+39
+00:03:33,940 --> 00:03:39,100
+different types of meat people people is an
+
+40
+00:03:39,100 --> 00:03:43,140
+uncount noun in general right but sometimes I can
+
+41
+00:03:43,140 --> 00:03:47,220
+say peoples peoples means what different races
+
+42
+00:03:47,220 --> 00:03:51,960
+this country this area includes different peoples
+
+43
+00:03:51,960 --> 00:03:57,270
+different races of people kinds of peopleالان نحن
+
+44
+00:03:57,270 --> 00:04:02,330
+نبحث عن هذه الكلمات هل يمكنك أن تبدأ؟ كل الجروب
+
+45
+00:04:02,330 --> 00:04:06,830
+مصنع من أشياء مشابهة أشياء مشابهة، نعم أشياء
+
+46
+00:04:06,830 --> 00:04:09,110
+مشابهة، أشياء مشابهة، أشياء مشابهة، أشياء مشابهة،
+
+47
+00:04:09,110 --> 00:04:10,250
+أشياء مشابهة، أشياء مشابهة، أشياء مشابهة، أشياء
+
+48
+00:04:10,250 --> 00:04:12,530
+مشابهة، أشياء مشابهة، أشياء مشابهة، أشياء مشابهة،
+
+49
+00:04:12,530 --> 00:04:13,890
+أشياء مشابهة، أشياء مشابهة، أشياء مشابهة، أشياء
+
+50
+00:04:13,890 --> 00:04:20,130
+مشابهة، أشياء مشابهة، أشياء مشابهة، أشياء مشابهة،
+
+51
+00:04:20,130 --> 00:04:28,010
+أشياء مشابهة، أmachinery .. email .. make up ..
+
+52
+00:04:28,010 --> 00:04:32,570
+money .. cash .. change .. bus .. sail .. scenery
+
+53
+00:04:32,570 --> 00:04:38,630
+.. stop trafficOkay now they are what non count
+
+54
+00:04:38,630 --> 00:04:44,950
+nouns I say for example scenery okay this is I
+
+55
+00:04:44,950 --> 00:04:49,350
+talk about a beautiful scenery okay beautiful
+
+56
+00:04:49,350 --> 00:04:54,150
+scenery and we talk about fruit furniture they are
+
+57
+00:04:54,150 --> 00:04:58,570
+non count nouns now what about the other group yes
+
+58
+00:04:58,570 --> 00:05:00,550
+please go on مريدة
+
+59
+00:05:02,950 --> 00:05:07,910
+flux water, coffee, tea, milk, oil, soup, gas,
+
+60
+00:05:08,150 --> 00:05:15,030
+oil, gasoline, flood, truck okay thank you now
+
+61
+00:05:15,030 --> 00:05:20,090
+liquids okay water, coffee and so on they are in
+
+62
+00:05:20,090 --> 00:05:23,690
+general non count nouns but some of them can be
+
+63
+00:05:23,690 --> 00:05:28,440
+used as what?count nouns water for example water
+
+64
+00:05:28,440 --> 00:05:32,340
+different types of water coffee coffees and so on
+
+65
+00:05:32,340 --> 00:05:38,100
+next one please سحر butter
+
+66
+00:05:38,100 --> 00:05:43,360
+butter cheese milk gold iron silver glass paper
+
+67
+00:05:43,360 --> 00:05:47,000
+cotton wool thank you very much good next one
+
+68
+00:05:47,000 --> 00:05:52,280
+gases steam oil oxygen nitrogen smoke smoke
+
+69
+00:05:52,280 --> 00:05:59,270
+pollutionOkay thank you what is smoke smoke and
+
+70
+00:05:59,270 --> 00:06:10,170
+fog smoke and fog okay you know smoke and
+
+71
+00:06:10,170 --> 00:06:13,590
+fog
+
+72
+00:06:13,590 --> 00:06:17,010
+the
+
+73
+00:06:17,010 --> 00:06:20,450
+first two letters and the last two letters okay
+
+74
+00:06:20,450 --> 00:06:24,830
+smokeyes thank you go on please next one
+
+75
+00:06:24,830 --> 00:06:31,790
+verticals, rice, cheese, corn, duck, deer, bus,
+
+76
+00:06:32,130 --> 00:06:36,990
+cow, grass, chair, pigeon, sow, sand, sugar, pig
+
+77
+00:06:36,990 --> 00:06:42,310
+etc thank you abstractions yes please read about
+
+78
+00:06:42,310 --> 00:06:45,510
+the abstractions ياسمين adverse information news
+
+79
+00:06:45,510 --> 00:06:49,550
+evidence where are you readingWhere are you
+
+80
+00:06:49,550 --> 00:06:51,930
+reading? Yes start from here please patience,
+
+81
+00:06:52,230 --> 00:06:56,610
+beauty, confidence, courage, education, enjoyment,
+
+82
+00:06:57,170 --> 00:07:00,050
+fun, happiness, health, health, honesty,
+
+83
+00:07:01,050 --> 00:07:05,530
+hospitality, importance, intelligence, justice,
+
+84
+00:07:05,830 --> 00:07:10,210
+knowledge, laughter, luck, music, patents
+
+85
+00:07:10,210 --> 00:07:15,010
+patience, peace, pride, progress, react
+
+86
+00:07:18,210 --> 00:07:22,870
+recreation, significance, sleep, truth, violence,
+
+87
+00:07:23,050 --> 00:07:28,550
+wealth thank you very much, Noor go on advice,
+
+88
+00:07:28,850 --> 00:07:32,930
+information, news, evidence, proof, etc, time,
+
+89
+00:07:33,150 --> 00:07:37,010
+space, energy, etc, homework, work, grammar,
+
+90
+00:07:37,310 --> 00:07:39,890
+slang, vocabulary thank you, so what about this
+
+91
+00:07:39,890 --> 00:07:45,270
+word vocabulary, is it a count or an uncountSo
+
+92
+00:07:45,270 --> 00:07:49,550
+does it accept the S؟ نعم نعم نعم نعم نعم نعم نعم
+
+93
+00:07:49,550 --> 00:07:50,230
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+94
+00:07:50,230 --> 00:07:50,570
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+95
+00:07:50,570 --> 00:07:52,070
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+96
+00:07:52,070 --> 00:07:52,350
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+97
+00:07:52,350 --> 00:07:54,510
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+98
+00:07:54,510 --> 00:07:54,710
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+99
+00:07:54,710 --> 00:07:55,290
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+100
+00:07:55,290 --> 00:07:57,350
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+101
+00:07:57,350 --> 00:08:13,210
+نعم نعم نعم نعم نعم ن
+
+102
+00:08:13,290 --> 00:08:22,430
+Okay thank you next one نجوة recreation thank
+
+103
+00:08:22,430 --> 00:08:26,350
+you
+
+104
+00:08:26,350 --> 00:08:33,870
+next one yes please thank
+
+105
+00:08:33,870 --> 00:08:37,290
+you
+
+106
+00:08:37,290 --> 00:08:43,160
+gerunds in general yes نيفينnow listen we say
+
+107
+00:08:43,160 --> 00:08:48,400
+natural okay nature and natural okay look nature
+
+108
+00:08:48,400 --> 00:08:55,980
+it is the noun natural yeah yeah sleep
+
+109
+00:08:55,980 --> 00:09:00,240
+not
+
+110
+00:09:00,240 --> 00:09:03,200
+completely water not completely ice between this
+
+111
+00:09:03,200 --> 00:09:04,680
+and that okay
+
+112
+00:09:09,750 --> 00:09:16,170
+thank you now let's have an exercise add final s
+
+113
+00:09:16,170 --> 00:09:20,210
+es to the nouns in italics if necessary don't add
+
+114
+00:09:20,210 --> 00:09:23,750
+or change any other words only the nouns in
+
+115
+00:09:23,750 --> 00:09:27,490
+italics outside my room i can see a lot of tree
+
+116
+00:09:27,490 --> 00:09:31,710
+okay go on complete who wants to do this one come
+
+117
+00:09:31,710 --> 00:09:37,910
+please come add s or es it means make plural
+
+118
+00:09:47,320 --> 00:09:52,520
+outside my window I can see a lot of trees which
+
+119
+00:09:52,520 --> 00:09:59,110
+is grass, trees and flowersone I can see a lot of
+
+120
+00:09:59,110 --> 00:10:04,270
+trees very good thank you and this is because it's
+
+121
+00:10:04,270 --> 00:10:10,450
+the end of the sh okay good good so it ends with
+
+122
+00:10:10,450 --> 00:10:15,950
+sh so you in the plural you should add es good now
+
+123
+00:10:15,950 --> 00:10:21,230
+grass shall we add s or es why not you are right
+
+124
+00:10:21,230 --> 00:10:27,180
+whyshe is speaking why don't we add s or es to
+
+125
+00:10:27,180 --> 00:10:32,360
+grass okay it is a non count noun and doesn't
+
+126
+00:10:32,360 --> 00:10:37,640
+accept you are right what about dirt non count
+
+127
+00:10:37,640 --> 00:10:45,820
+noun good thank you and thank you and what good
+
+128
+00:10:45,820 --> 00:10:50,380
+thank you very much thank you next one number four
+
+129
+00:10:50,380 --> 00:10:51,500
+come please
+
+130
+00:11:06,340 --> 00:11:14,300
+yes read it now some ha some some indicates what
+
+131
+00:11:14,300 --> 00:11:18,540
+is used to introduce a plural noun right okay
+
+132
+00:11:18,540 --> 00:11:22,840
+where is the noun after some advice is it just a
+
+133
+00:11:22,840 --> 00:11:26,060
+minute just a minute is it a count or a non count
+
+134
+00:11:26,060 --> 00:11:32,800
+noun advice is a non count noun so can i say
+
+135
+00:11:32,800 --> 00:11:38,200
+advice is nowe can never say advices okay so keep
+
+136
+00:11:38,200 --> 00:11:46,320
+it okay yeah Nadia also gave me some good yes
+
+137
+00:11:46,320 --> 00:11:50,180
+okay where is it what about this noun read it
+
+138
+00:11:50,180 --> 00:11:57,860
+please yes thank you أدئس أدئس good thank you very
+
+139
+00:11:57,860 --> 00:12:00,240
+much next one yes مروة
+
+140
+00:12:07,580 --> 00:12:15,560
+the pen is there good
+
+141
+00:12:15,560 --> 00:12:19,580
+good
+
+142
+00:12:19,580 --> 00:12:26,260
+shall
+
+143
+00:12:26,260 --> 00:12:28,940
+we add esto .. no thank you good
+
+144
+00:12:43,180 --> 00:12:57,320
+لنكمل رقم 6 رقم 6 تعال يا عزيزي و لا انا
+
+145
+00:12:57,320 --> 00:13:00,980
+انا انا انا
+
+146
+00:13:00,980 --> 00:13:02,380
+انا انا انا انا انا انا انا انا انا انا انا انا
+
+147
+00:13:02,380 --> 00:13:02,500
+انا انا انا انا انا انا انا انا انا انا انا انا
+
+148
+00:13:02,500 --> 00:13:02,520
+انا انا انا انا انا انا انا انا انا انا انا انا
+
+149
+00:13:02,520 --> 00:13:03,520
+انا انا انا انا انا انا انا انا انا انا انا انا
+
+150
+00:13:03,520 --> 00:13:03,680
+انا انا انا انا انا انا انا انا انا انا انا انا
+
+151
+00:13:03,680 --> 00:13:09,440
+انا انا انا انا انا انا انا انا انا انا انا انا
+
+152
+00:13:20,410 --> 00:13:27,890
+Okay thank you good glasses of water yeah windows
+
+153
+00:13:27,890 --> 00:13:33,130
+are made of a glass thank you what about a glass
+
+154
+00:13:33,130 --> 00:13:37,510
+this is a noun right it is non count okay thank
+
+155
+00:13:37,510 --> 00:13:41,870
+you in this sentence it is non count next one ندا
+
+156
+00:13:41,870 --> 00:13:42,910
+will you come
+
+157
+00:13:51,100 --> 00:14:00,720
+Okay now glasses I'm talking about what؟ glasses
+
+158
+00:14:01,890 --> 00:14:07,190
+Now in this sentence, this noun glass, is it count
+
+159
+00:14:07,190 --> 00:14:12,570
+or non-count? In this number eight, is it count or
+
+160
+00:14:12,570 --> 00:14:15,370
+non-count? Is it the same word as the previous
+
+161
+00:14:15,370 --> 00:14:19,370
+sentence? No, this is different, the first one in
+
+162
+00:14:19,370 --> 00:14:23,310
+general, the material, but now I mean this Okay,
+
+163
+00:14:23,410 --> 00:14:26,470
+go on please, so what shall you do? Okay, thank
+
+164
+00:14:26,470 --> 00:14:31,380
+you very much, goodnumber nine come please ياسمين
+
+165
+00:14:31,380 --> 00:14:41,000
+it
+
+166
+00:14:41,000 --> 00:14:44,720
+took me a lot of time to finish my homework I had
+
+167
+00:14:44,720 --> 00:14:49,240
+a lot of assignments assignments
+
+168
+00:14:49,240 --> 00:14:52,100
+thank you what about the other nouns you have time
+
+169
+00:14:52,100 --> 00:14:59,280
+homework good thank you very muchthank you yes
+
+170
+00:14:59,280 --> 00:15:05,960
+Noor come please
+
+171
+00:15:05,960 --> 00:15:15,440
+three times
+
+172
+00:15:15,440 --> 00:15:16,260
+good thank you
+
+173
+00:15:21,890 --> 00:15:25,170
+Now the word time is repeated in this sentence.
+
+174
+00:15:25,390 --> 00:15:29,210
+Look, three times, a lot of time. What's the
+
+175
+00:15:29,210 --> 00:15:32,810
+difference? Are they the same word? No, I have in
+
+176
+00:15:32,810 --> 00:15:35,790
+the first one. Yes, can you explain Marwa? I think
+
+177
+00:15:35,790 --> 00:15:40,390
+that for the first one, we will use count now, it
+
+178
+00:15:40,390 --> 00:15:44,390
+means months or something like that. Okay, thank
+
+179
+00:15:44,390 --> 00:15:48,510
+you. Expresses the number of times. Good. Next
+
+180
+00:15:48,510 --> 00:15:51,110
+one. Next one. Yeah.
+
+181
+00:15:54,420 --> 00:15:57,980
+أها you have been out you did one yes come please
+
+182
+00:15:57,980 --> 00:16:03,860
+كام مروة the air is full of smoke, dust, carbon
+
+183
+00:16:03,860 --> 00:16:09,700
+monoxide yes and many other harmful substances
+
+184
+00:16:09,700 --> 00:16:14,240
+here substances and why did you leave the other
+
+185
+00:16:14,240 --> 00:16:20,380
+announce smoke, dust, carbon dioxide okay good
+
+186
+00:16:25,260 --> 00:16:29,360
+Okay thank you and what is the what about the last
+
+187
+00:16:29,360 --> 00:16:37,540
+word the last word thank
+
+188
+00:16:37,540 --> 00:16:43,460
+you very much good check
+
+189
+00:16:43,460 --> 00:16:44,100
+your answers
+
+190
+00:16:55,820 --> 00:17:01,180
+Complete exercise 17 at home okay complete you
+
+191
+00:17:01,180 --> 00:17:04,340
+have some other sentences you can do that at home
+
+192
+00:17:04,340 --> 00:17:13,060
+or you want to do now do that at home also
+
+193
+00:17:13,060 --> 00:17:17,060
+exercise 19 do at home and check the answers you
+
+194
+00:17:17,060 --> 00:17:18,200
+have the answers okay
+
+195
+00:17:56,500 --> 00:18:04,960
+الان نحن نحب نتكلم عن الارتكال انت
+
+196
+00:18:04,960 --> 00:18:12,140
+تعرف الارتكال بالانجليزيةare divided
+
+197
+00:18:12,140 --> 00:18:21,460
+into what? definite and indefinite okay the
+
+198
+00:18:21,460 --> 00:18:28,740
+definite article is what? the indefinite a and a
+
+199
+00:18:28,740 --> 00:18:34,260
+okay sometimes we use thesometimes we use a
+
+200
+00:18:34,260 --> 00:18:39,160
+sometimes we use and and sometimes we use nothing
+
+201
+00:18:39,160 --> 00:18:43,420
+it is called zero article very good we use zero
+
+202
+00:18:43,420 --> 00:18:48,040
+article now
+
+203
+00:18:48,040 --> 00:18:59,120
+well
+
+204
+00:18:59,120 --> 00:19:04,540
+look at this sentenceread it خديجة a banana is
+
+205
+00:19:04,540 --> 00:19:11,540
+yellow which bananaany banana very good it is any
+
+206
+00:19:11,540 --> 00:19:16,380
+banana so general we don't mean a special one is
+
+207
+00:19:16,380 --> 00:19:19,320
+it the one in your house in my house in the market
+
+208
+00:19:19,320 --> 00:19:23,560
+in somalia in sudan in palestine it can be any
+
+209
+00:19:23,560 --> 00:19:28,360
+banana okay now banana is called a generic noun
+
+210
+00:19:28,360 --> 00:19:32,640
+generic noun not we are we don't mean a particular
+
+211
+00:19:32,640 --> 00:19:39,520
+one okay so it is genericand with this word with
+
+212
+00:19:39,520 --> 00:19:44,280
+this generic noun is introduced with what the
+
+213
+00:19:44,280 --> 00:19:49,220
+indefinite article a okay yes please read the
+
+214
+00:19:49,220 --> 00:19:55,500
+introduction a speaker use a speaker use uh
+
+215
+00:19:55,500 --> 00:20:00,260
+generic nouns to make generalizations
+
+216
+00:20:00,260 --> 00:20:04,300
+generalization a computer saves our time which
+
+217
+00:20:04,300 --> 00:20:10,530
+computerHoneycomb. Okay.anyone thank you go on a
+
+218
+00:20:10,530 --> 00:20:19,410
+generic noun represents a whole class of things it
+
+219
+00:20:19,410 --> 00:20:29,110
+is not a specific real thing but really a symbol
+
+220
+00:20:29,110 --> 00:20:33,470
+of a whole group of a whole group thank you very
+
+221
+00:20:33,470 --> 00:20:38,060
+much now when I say a student should work hardany
+
+222
+00:20:38,060 --> 00:20:42,860
+student any student everywhere every time okay a
+
+223
+00:20:42,860 --> 00:20:46,380
+student should work hard a driver should be
+
+224
+00:20:46,380 --> 00:20:51,640
+careful which driver any driver all drivers okay
+
+225
+00:20:51,640 --> 00:20:56,820
+all drivers so driver is introduced by what?A, a
+
+226
+00:20:56,820 --> 00:21:01,020
+pen is useful. It helps us in writing. Which pen?
+
+227
+00:21:01,380 --> 00:21:04,300
+Is it only this pen? No. Can you give me some
+
+228
+00:21:04,300 --> 00:21:07,140
+other examples? Use generic noun with the
+
+229
+00:21:07,140 --> 00:21:11,620
+indefinite article A to show general things. Who
+
+230
+00:21:11,620 --> 00:21:12,720
+can give me an example?
+
+231
+00:21:15,500 --> 00:21:20,920
+Yes, Morida. Very good. Thank you. A book is
+
+232
+00:21:20,920 --> 00:21:28,720
+interesting. Thank you.good yeah thank
+
+233
+00:21:28,720 --> 00:21:39,760
+you yeah again a girl is beautiful a girl which
+
+234
+00:21:39,760 --> 00:21:46,120
+girl okay thank you a girl or a child thank you in
+
+235
+00:21:46,120 --> 00:21:49,780
+general she likes girls thank you now look at this
+
+236
+00:21:49,780 --> 00:21:53,840
+look at this sentenceit is the same repeated okay
+
+237
+00:21:53,840 --> 00:21:57,580
+now let's look at the other one when I say bananas
+
+238
+00:21:57,580 --> 00:22:04,500
+are yellow bananas are yellow students should work
+
+239
+00:22:04,500 --> 00:22:10,920
+hard drivers should be careful computers can waste
+
+240
+00:22:10,920 --> 00:22:15,110
+our timeNow which drivers, which bananas, which
+
+241
+00:22:15,110 --> 00:22:19,570
+students? All. So what did I use to introduce the
+
+242
+00:22:19,570 --> 00:22:23,370
+generic noun here? Zero. Zero. Look, this is
+
+243
+00:22:23,370 --> 00:22:27,590
+singular. Okay? Introduced by indefinite article.
+
+244
+00:22:28,030 --> 00:22:32,490
+And this is plural. Introduced by zero article.
+
+245
+00:22:33,130 --> 00:22:36,650
+Now how can we make generic nouns? Who can tell me
+
+246
+00:22:36,650 --> 00:22:40,130
+according to what you .. to what we said? Yes
+
+247
+00:22:40,130 --> 00:22:43,630
+Nada.إذا كنا نستخدم singular نستخدم singular
+
+248
+00:22:43,630 --> 00:22:48,670
+نستخدم singular نستخدم singular نستخدم singular
+
+249
+00:22:48,670 --> 00:22:53,970
+نستخدم singular نستخدم singular نستخدم singular
+
+250
+00:22:53,970 --> 00:23:02,930
+نستخدم singular نستخدم singular نستخدم
+
+251
+00:23:05,980 --> 00:23:09,260
+Any apple؟ Is it a generic or a particular noun
+
+252
+00:23:09,260 --> 00:23:12,520
+here؟ Generic. So what did we use to introduce
+
+253
+00:23:12,520 --> 00:23:17,920
+this generic noun؟ An is indefinite article again.
+
+254
+00:23:18,220 --> 00:23:18,760
+Thank you.
+
+255
+00:23:21,940 --> 00:23:27,900
+Now what about fruit? Is it a count or non-count
+
+256
+00:23:27,900 --> 00:23:31,260
+noun? Non-count noun. Okay again when I say fruit
+
+257
+00:23:31,260 --> 00:23:36,310
+is good for youfruit is good for you which fruit?
+
+258
+00:23:36,410 --> 00:23:42,850
+in general did I use an article? no so with
+
+259
+00:23:42,850 --> 00:23:48,330
+generic non count nouns we use what? zero article
+
+260
+00:23:48,330 --> 00:23:52,670
+good now we use zero article with .. who can tell
+
+261
+00:23:52,670 --> 00:24:00,490
+me with? plural count nounsand non count nouns to
+
+262
+00:24:00,490 --> 00:24:04,130
+make generic nouns okay to make generic nouns good
+
+263
+00:24:04,130 --> 00:24:07,970
+and what do we use with singular count nouns yes
+
+264
+00:24:07,970 --> 00:24:13,070
+please we use a or an thank you very much we use a
+
+265
+00:24:13,070 --> 00:24:18,390
+or an good now look at this sentence yes please
+
+266
+00:24:18,390 --> 00:24:24,500
+readwhich window in your house in my house in the
+
+267
+00:24:24,500 --> 00:24:29,080
+university okay any window thank you very much yes
+
+268
+00:24:29,080 --> 00:24:36,160
+دعا read the other one which doctor any doctor so
+
+269
+00:24:36,160 --> 00:24:39,940
+is this a generic noun okay good thank you yes
+
+270
+00:24:39,940 --> 00:24:46,020
+please read the other one okay parents must give a
+
+271
+00:24:46,020 --> 00:24:48,820
+child love where what about that where is the
+
+272
+00:24:48,820 --> 00:24:52,840
+generic noun in this sentenceone speaker please
+
+273
+00:24:52,840 --> 00:24:57,400
+yeah thank you now what did we use to introduce
+
+274
+00:24:57,400 --> 00:25:02,240
+parents? zero article very good and you want to
+
+275
+00:25:02,240 --> 00:25:06,980
+say something you want to say something you say it
+
+276
+00:25:06,980 --> 00:25:12,670
+speak aloudwe are talking about generic nouns this
+
+277
+00:25:12,670 --> 00:25:16,930
+is a generic noun okay any other generic nouns in
+
+278
+00:25:16,930 --> 00:25:22,510
+this sentence صحر a child which child any child
+
+279
+00:25:22,510 --> 00:25:27,250
+okay so all parents and all children right good
+
+280
+00:25:27,250 --> 00:25:35,310
+now next one please next one اتفضلي okay a box has
+
+281
+00:25:35,310 --> 00:25:41,070
+which boxGood, so this is a generic, this is for
+
+282
+00:25:41,070 --> 00:25:44,990
+you now, go on, this is for you An apple can be
+
+283
+00:25:44,990 --> 00:25:48,930
+red, green or yellow Good, an apple can be red,
+
+284
+00:25:49,090 --> 00:25:53,350
+green or yellow, which apple? In general So again,
+
+285
+00:25:53,650 --> 00:25:58,190
+they are generic nouns, okay, singular generic
+
+286
+00:25:58,190 --> 00:26:02,250
+nouns Yes
+
+287
+00:26:02,250 --> 00:26:06,480
+Do you want me to read it? Read ithowever this is
+
+288
+00:26:06,480 --> 00:26:09,140
+sometimes used with singular generic count nouns,
+
+289
+00:26:09,420 --> 00:26:12,700
+non plural generic count nouns, non generic non
+
+290
+00:26:12,700 --> 00:26:17,040
+count nouns, generic ده is commonly used with in
+
+291
+00:26:17,040 --> 00:26:20,980
+particular species
+
+292
+00:26:20,980 --> 00:26:23,020
+of animals
+
+293
+00:26:26,580 --> 00:26:30,720
+Sometimes we use .. sometimes the is used with
+
+294
+00:26:30,720 --> 00:26:34,720
+what? A singular generic count noun. Now when I
+
+295
+00:26:34,720 --> 00:26:40,460
+say a window, a man, a student, I used a with the
+
+296
+00:26:40,460 --> 00:26:45,460
+singular generic, right? But sometimes we use
+
+297
+00:26:45,460 --> 00:26:51,280
+what? We use the. Look.the blue whale is the
+
+298
+00:26:51,280 --> 00:26:56,980
+largest mammal on earth the blue whale the blue
+
+299
+00:26:56,980 --> 00:27:04,510
+whale now this noundoes it reflect or does it show
+
+300
+00:27:04,510 --> 00:27:09,890
+a generic or a particular noun it means any blue
+
+301
+00:27:09,890 --> 00:27:14,790
+whale right any blue whale the elephant the white
+
+302
+00:27:14,790 --> 00:27:19,110
+elephant for example okay the elephant is the
+
+303
+00:27:19,110 --> 00:27:23,910
+largest is the largest which elephant okay the
+
+304
+00:27:23,910 --> 00:27:24,970
+white elephant
+
+305
+00:27:29,150 --> 00:27:34,970
+الليل اللي هو
+
+306
+00:27:34,970 --> 00:27:39,790
+أكثر قوة للليل اللي هو أكثر قوة للليلanimal the
+
+307
+00:27:39,790 --> 00:27:44,110
+lion is the strongest animal the lion which lion
+
+308
+00:27:44,110 --> 00:27:49,250
+so now we use the with these animals with these
+
+309
+00:27:49,250 --> 00:27:53,690
+groups of animals to express what generic nouns so
+
+310
+00:27:53,690 --> 00:27:57,850
+this noun here is what is generic it is generic
+
+311
+00:27:57,850 --> 00:28:03,610
+again this is an exception we said we use a or an
+
+312
+00:28:03,610 --> 00:28:10,190
+to expressgeneric nouns okay singular right but
+
+313
+00:28:10,190 --> 00:28:13,170
+now we have singular this is singular and this is
+
+314
+00:28:13,170 --> 00:28:16,630
+singular but when i talk about especially groups
+
+315
+00:28:16,630 --> 00:28:21,790
+species of animals for example i also i can use
+
+316
+00:28:21,790 --> 00:28:25,450
+the and the here is also the noun is generic
+
+317
+00:28:25,450 --> 00:28:30,310
+number two when i say who invented the telephone
+
+318
+00:28:30,310 --> 00:28:35,680
+who invented the telephone which telephoneyes it
+
+319
+00:28:35,680 --> 00:28:40,900
+is in general so the telephone is an invention so
+
+320
+00:28:40,900 --> 00:28:47,220
+again I use the with this invention and telephone
+
+321
+00:28:47,220 --> 00:28:53,580
+here is a generic noun again now read this please
+
+322
+00:28:53,580 --> 00:29:02,890
+yes ولاالكمبيوتر سيفعل رولة كبيرة في كل حياتنا
+
+323
+00:29:02,890 --> 00:29:10,620
+شكرا، الكمبيوتر، أي كمبيوتر؟ أي شخص؟Is it a
+
+324
+00:29:10,620 --> 00:29:14,640
+generic noun؟ The computer is an invention, right?
+
+325
+00:29:15,080 --> 00:29:18,640
+So with inventions we use that. Thank you. And
+
+326
+00:29:18,640 --> 00:29:24,880
+finally now next one please read. What is the
+
+327
+00:29:24,880 --> 00:29:28,380
+piano? It is an instrument. I say the piano. Good.
+
+328
+00:29:28,780 --> 00:29:35,410
+Which piano? Okay, go on please.thank you so they
+
+329
+00:29:35,410 --> 00:29:39,110
+are instruments musical instruments for example
+
+330
+00:29:39,110 --> 00:29:43,950
+okay we use that and still we are using or we are
+
+331
+00:29:43,950 --> 00:29:47,850
+dealing with what we are dealing with generic
+
+332
+00:29:47,850 --> 00:29:51,930
+nouns now I want someone of you to make a summary
+
+333
+00:29:51,930 --> 00:29:57,650
+for yeah with the computer نقدر يعني نستخدم a
+
+334
+00:29:57,650 --> 00:29:58,090
+computer
+
+335
+00:30:01,670 --> 00:30:06,770
+this is a good question can we say a computer can
+
+336
+00:30:06,770 --> 00:30:14,130
+we say a computer saves our time why
+
+337
+00:30:14,130 --> 00:30:24,180
+not yes نجواالان في هذا الاسم عندما اقول الكمبيوتر
+
+338
+00:30:24,180 --> 00:30:28,980
+يخفف وقتنا هو إبتكار عامة مع إبتكارات نستخدمها
+
+339
+00:30:33,380 --> 00:30:37,780
+إذا قلت بشكل عام هذه الطريقة العامة للإبداع
+
+340
+00:30:37,780 --> 00:30:45,360
+نستخدمها حتى نصنع كلمة عامة لا تستخدم أشياء أخرى
+
+341
+00:30:45,360 --> 00:30:49,140
+هذا هو أكتر استخدام عامة هذا هو الطريقة الصحيحة
+
+342
+00:30:49,140 --> 00:30:54,720
+لإستخدامها اذا قلت اشتري كمبيوتر عندما أقول اشتري
+
+343
+00:30:54,720 --> 00:31:02,150
+كمبيوتر هذا مختلف لكن الكمبيوتر يحفظ إنه مميزعلى
+
+344
+00:31:02,150 --> 00:31:10,430
+هذا النوع من الاصطناع الان باستخدام ا
+
+345
+00:31:10,430 --> 00:31:18,170
+او سم مع نوعات غير محددة نوعات غير محددة ماذا؟
+
+346
+00:31:18,170 --> 00:31:24,030
+أشياء حقيقية، أشياء حقيقية، كيف؟ عندما أقول على
+
+347
+00:31:24,030 --> 00:31:28,810
+سبيل المثال هذا الـ penthis pen I'm talking about
+
+348
+00:31:28,810 --> 00:31:34,010
+now look at the previous example we say a pen a
+
+349
+00:31:34,010 --> 00:31:37,650
+pen this is simple it can be any pen but when I
+
+350
+00:31:37,650 --> 00:31:43,990
+say this pen okay give me the pen give me the pen
+
+351
+00:31:43,990 --> 00:31:49,420
+which pen she knows which pen I mean okayso this
+
+352
+00:31:49,420 --> 00:31:52,420
+is not simple like I'm talking about a real thing
+
+353
+00:31:52,420 --> 00:31:57,240
+okay I'm talking about a real thing now we might
+
+354
+00:31:57,240 --> 00:32:03,000
+say I ate a banana I ate a banana okay what do you
+
+355
+00:32:03,000 --> 00:32:11,160
+understand from this sentence it's
+
+356
+00:32:11,160 --> 00:32:18,140
+not specific yeah it is generic noun againWe want
+
+357
+00:32:18,140 --> 00:32:24,140
+to make it specific, not generic. We want to make
+
+358
+00:32:24,140 --> 00:32:27,840
+it specific or generic. When I say for example
+
+359
+00:32:27,840 --> 00:32:32,460
+فاطمة thank you for the sandwich. What do you
+
+360
+00:32:32,460 --> 00:32:33,540
+understand؟
+
+361
+00:32:37,490 --> 00:32:41,870
+it means that she gave me a sandwich I'm thanking
+
+362
+00:32:41,870 --> 00:32:45,470
+her for that sandwich thank you for the banana
+
+363
+00:32:45,470 --> 00:32:51,690
+okay thank you for the book I want a book on
+
+364
+00:32:51,690 --> 00:32:57,810
+grammarأي كتاب، صح؟ لكن عندما أقول اعطيني الكتاب،
+
+365
+00:32:57,810 --> 00:33:02,170
+شكرا للكتاب، يعني أنها أعطيتني كتاب محدد و أنا
+
+366
+00:33:02,170 --> 00:33:08,860
+أشكرها على ذلك الكتاب.plural count nouns I ate
+
+367
+00:33:08,860 --> 00:33:13,900
+some bananas and I ate some fruit okay read please
+
+368
+00:33:13,900 --> 00:33:17,840
+the note some is often used with definite plural
+
+369
+00:33:17,840 --> 00:33:24,160
+count nouns with indefinite now bananas I ate some
+
+370
+00:33:24,160 --> 00:33:30,460
+bananas I need some boxOkay, indefinite, we don't
+
+371
+00:33:30,460 --> 00:33:34,620
+mean certain ones, gone And indefinite, non count
+
+372
+00:33:34,620 --> 00:33:38,180
+nouns, in addition Look, this is a non count and
+
+373
+00:33:38,180 --> 00:33:42,360
+this is what? Count, gone In addition to some
+
+374
+00:33:42,360 --> 00:33:46,860
+speaker might use two and few several a lot of etc
+
+375
+00:33:46,860 --> 00:33:51,780
+with plural count nouns or a little a lot of with
+
+376
+00:33:51,780 --> 00:33:56,700
+non count nouns So instead of what?some we say a
+
+377
+00:33:56,700 --> 00:34:03,840
+lot of okay we say a lot of and we can use what a
+
+378
+00:34:03,840 --> 00:34:08,800
+little a little with what a little for example
+
+379
+00:34:08,800 --> 00:34:14,460
+with non count a little sugar or little sugar okay
+
+380
+00:34:14,460 --> 00:34:19,860
+and so on definite
+
+381
+00:34:19,860 --> 00:34:27,220
+nouns when I say thank you for the bookthank you
+
+382
+00:34:27,220 --> 00:34:31,740
+for the story thank you for the sandwich thank you
+
+383
+00:34:31,740 --> 00:34:36,740
+for the banana okay is the noun here in these
+
+384
+00:34:36,740 --> 00:34:39,500
+sentences generic or specific or particular
+
+385
+00:34:39,500 --> 00:34:46,420
+specific okay i'm talking about specific nouns not
+
+386
+00:34:46,420 --> 00:34:50,320
+generic definite specific particular or definite
+
+387
+00:34:50,320 --> 00:34:53,880
+so when i say thank you for the banana or thank
+
+388
+00:34:53,880 --> 00:35:00,620
+you for the bananas lookهذا كلمة مفعولة و هذا كلمة
+
+389
+00:35:00,620 --> 00:35:05,260
+مفعولة مرة أخرى عندما أقول شكرا لك على الكتاب أعرف
+
+390
+00:35:05,260 --> 00:35:12,460
+أنك تعرفين أي كتاب أعنيه أعرف أنك أعطيتني كتاب أمس
+
+391
+00:35:12,460 --> 00:35:17,120
+، أنت أعطيتني شيء أمس و أراك اليوم شكرا لك على
+
+392
+00:35:17,120 --> 00:35:22,630
+الكتاب شكرا لبنانا شكرا لand so on so I know that
+
+393
+00:35:22,630 --> 00:35:27,430
+you know which one I mean I talk so it is again
+
+394
+00:35:27,430 --> 00:35:34,510
+definite look thank you for the fruit it is what
+
+395
+00:35:34,510 --> 00:35:40,510
+non count non count is it generic or definite term
+
+396
+00:35:40,510 --> 00:35:47,600
+thank you for the fruitwho's the speaker? I want
+
+397
+00:35:47,600 --> 00:35:52,100
+one speaker yes please it is definite okay thank
+
+398
+00:35:52,100 --> 00:35:54,740
+you for the fruit you gave me some fruit and I'm
+
+399
+00:35:54,740 --> 00:35:59,880
+thanking you okay thank you for the teathank you
+
+400
+00:35:59,880 --> 00:36:04,600
+for the tea right؟ it is definite you gave me some
+
+401
+00:36:04,600 --> 00:36:08,020
+tea for example and I'm thanking you for that okay
+
+402
+00:36:08,020 --> 00:36:13,080
+read please the explanation or the note yes please
+
+403
+00:36:13,080 --> 00:36:16,780
+read it the speaker uses the because the listener
+
+404
+00:36:16,780 --> 00:36:19,720
+knows which specific banana the speaker is talking
+
+405
+00:36:19,720 --> 00:36:23,410
+aboutthat particular banana which the listener
+
+406
+00:36:23,410 --> 00:36:28,970
+gave to the speaker notice that it is used with
+
+407
+00:36:28,970 --> 00:36:32,190
+both singular and plural countings and non
+
+408
+00:36:32,190 --> 00:36:35,770
+countings thank you now that is used with singular
+
+409
+00:36:35,770 --> 00:36:40,950
+the banana right plural plural okay and what non
+
+410
+00:36:40,950 --> 00:36:45,210
+count non count non count thank you now look at
+
+411
+00:36:45,210 --> 00:36:51,070
+this exerciseadd a and if necessary write zero
+
+412
+00:36:51,070 --> 00:36:54,990
+article if the noun is non count capitalize as
+
+413
+00:36:54,990 --> 00:37:03,970
+necessary again again listen or an or what zero
+
+414
+00:37:03,970 --> 00:37:08,510
+article number one number one come come please
+
+415
+00:37:08,510 --> 00:37:10,050
+come i want you to come here
+
+416
+00:37:17,760 --> 00:37:20,100
+Okay, get ready number two. Who wants to do number
+
+417
+00:37:20,100 --> 00:37:29,180
+two? Yes, good. Get ready. We saywhy the tennis?
+
+418
+00:37:29,880 --> 00:37:34,760
+just a minute just a minute why the tennis? now he
+
+419
+00:37:34,760 --> 00:37:39,360
+wants us to use a or an don't use that okay or
+
+420
+00:37:39,360 --> 00:37:45,240
+zero article a tennis okay any tennis that's right
+
+421
+00:37:45,240 --> 00:37:52,440
+you are right it is zero article it is not a
+
+422
+00:37:52,440 --> 00:37:56,960
+tennis very good thank you it is zero article okay
+
+423
+00:37:58,330 --> 00:38:02,630
+it is zero article thank you yes please next one
+
+424
+00:38:02,630 --> 00:38:09,430
+you come come on please tennis okay zero article
+
+425
+00:38:09,430 --> 00:38:13,890
+now listen let's agree that we write it like that
+
+426
+00:38:13,890 --> 00:38:16,290
+okay this is zero article
+
+427
+00:38:23,990 --> 00:38:28,370
+very good a tennis player now what's the
+
+428
+00:38:28,370 --> 00:38:32,050
+difference between tennis here in general like
+
+429
+00:38:32,050 --> 00:38:35,210
+football when I say this is a generic noun tennis
+
+430
+00:38:35,210 --> 00:38:40,170
+zero article but now I'm talking about one player
+
+431
+00:38:40,170 --> 00:38:45,110
+count noun one player count noun yes please come
+
+432
+00:38:45,110 --> 00:38:50,150
+next one who's asking
+
+433
+00:38:53,100 --> 00:39:00,100
+you have a question why
+
+434
+00:39:00,100 --> 00:39:11,220
+did you why n not a for example because it is yeah
+
+435
+00:39:11,220 --> 00:39:15,040
+it starts with a vowel yeah it starts with a vowel
+
+436
+00:39:15,040 --> 00:39:19,240
+thank you good it starts with a vowel come please
+
+437
+00:39:19,240 --> 00:39:30,470
+and island isو الوقت قد انتهى الوقت قد انتهى الوقت
+
+438
+00:39:30,470 --> 00:39:35,510
+حسنا افعلها افعلها افعلها نهائي نهائي نهائي نهائي
+
+439
+00:39:35,510 --> 00:39:38,110
+نهائي نهائي نهائي نهائي نهائي نهائي نهائي نهائي
+
+440
+00:39:38,110 --> 00:39:40,230
+نهائي نهائي نهائي نهائي نهائي نهائي نهائي نهائي
+
+441
+00:39:40,230 --> 00:39:43,190
+نهائي نهائي نهائي نهائي نهائي نهائي نهائي نهائي
+
+442
+00:39:43,190 --> 00:39:48,050
+نهائي نهائي نهائي ن
+
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/jaTPlcCrh0Q_raw.json b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/jaTPlcCrh0Q_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..3bd4bf03595eb0657622e1a7004f90fd4113b32e
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/jaTPlcCrh0Q_raw.json
@@ -0,0 +1 @@
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error where is the error furniture okay", "tokens": [3424, 257, 3456, 445, 257, 3456, 445, 257, 3456, 2086, 689, 307, 264, 6713, 689, 307, 264, 6713, 15671, 1392], "avg_logprob": -0.26674106007530574, "compression_ratio": 1.6065573770491803, "no_speech_prob": 0.0, "words": [{"start": 1164.6299999999999, "end": 1165.31, "word": "just", "probability": 0.1444091796875}, {"start": 1165.31, "end": 1165.99, "word": " a", "probability": 0.98046875}, {"start": 1165.99, "end": 1166.33, "word": " minute", "probability": 0.92138671875}, {"start": 1166.33, "end": 1166.81, "word": " just", "probability": 0.30615234375}, {"start": 1166.81, "end": 1167.01, "word": " a", "probability": 0.984375}, {"start": 1167.01, "end": 1167.33, "word": " minute", "probability": 0.943359375}, {"start": 1167.33, "end": 1168.31, "word": " just", "probability": 0.39892578125}, {"start": 1168.31, "end": 1168.59, "word": " a", "probability": 0.98779296875}, {"start": 1168.59, "end": 1168.91, "word": " minute", 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We don't use what. Of is not used when the noun is non-specific. Many books. A group of books. This is general. Now one book. It can be any book. Did I identify the book? So the noun is not specific, is non-specific. 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two hyphens okay", "tokens": [47545, 1296, 264, 732, 2283, 1296, 286, 362, 1045, 2283, 370, 264, 2477, 47059, 307, 3720, 1296, 264, 2283, 286, 362, 1045, 2283, 286, 393, 2464, 732, 2477, 950, 694, 1392], "avg_logprob": -0.23547363560646772, "compression_ratio": 1.6477272727272727, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 3031.8999999999996, "end": 3032.74, "word": "sorry", "probability": 0.32080078125}, {"start": 3032.74, "end": 3033.58, "word": " between", "probability": 0.59716796875}, {"start": 3033.58, "end": 3033.94, "word": " the", "probability": 0.87548828125}, {"start": 3033.94, "end": 3034.16, "word": " two", "probability": 0.921875}, {"start": 3034.16, "end": 3034.58, "word": " words", "probability": 0.92041015625}, {"start": 3034.58, "end": 3035.44, "word": " between", "probability": 0.314453125}, {"start": 3035.44, "end": 3038.58, "word": " I", "probability": 0.60986328125}, {"start": 3038.58, "end": 3039.26, "word": " have", "probability": 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3062.47, "word": " عمرها", "probability": 0.5409952799479166}, {"start": 3062.47, "end": 3063.17, "word": " تتغيير", "probability": 0.78056640625}, {"start": 3063.17, "end": 3063.53, "word": " الليل", "probability": 0.21712239583333334}, {"start": 3063.53, "end": 3063.99, "word": " ،", "probability": 0.416259765625}, {"start": 3063.99, "end": 3065.17, "word": " لذلك", "probability": 0.7845052083333334}, {"start": 3065.17, "end": 3065.49, "word": " يجب", "probability": 0.8505859375}, {"start": 3065.49, "end": 3065.49, "word": " أن", "probability": 0.826171875}, {"start": 3065.49, "end": 3065.49, "word": " يكون", "probability": 0.77197265625}, {"start": 3065.49, "end": 3065.55, "word": " الليل", "probability": 0.6420084635416666}, {"start": 3065.55, "end": 3066.25, "word": " التغيير", "probability": 0.8638916015625}, {"start": 3066.25, "end": 3067.39, "word": " حيفنية", "probability": 0.34368896484375}, {"start": 3067.39, "end": 3067.81, "word": " إذا", "probability": 0.55487060546875}, {"start": 3067.81, "end": 3068.65, "word": " استخدمت", "probability": 0.8612060546875}, {"start": 3068.65, "end": 3069.31, "word": " الحفن", "probability": 0.5930989583333334}, {"start": 3069.31, "end": 3069.71, "word": " بين", "probability": 0.8544921875}, {"start": 3069.71, "end": 3070.27, "word": " الكلمات", "probability": 0.6748046875}, {"start": 3070.27, "end": 3070.75, "word": " ،", "probability": 0.391845703125}, {"start": 3070.75, "end": 3071.35, "word": " لذلك", "probability": 0.8108723958333334}, {"start": 3071.35, "end": 3071.55, "word": " الآن", "probability": 0.667236328125}, {"start": 3071.55, "end": 3071.95, "word": " لدي", "probability": 0.869140625}, {"start": 3071.95, "end": 3072.29, "word": " ثلاث", "probability": 0.9027099609375}, {"start": 3072.29, "end": 3072.77, "word": " كلمات", "probability": 0.7229817708333334}, {"start": 3072.77, "end": 3073.39, "word": " يأخذون", "probability": 0.6619140625}, {"start": 3073.39, "end": 3073.81, "word": " ماذا", "probability": 0.7471516927083334}, {"start": 3073.81, "end": 3075.81, "word": " يأخذون", "probability": 0.7395751953125}], "temperature": 1.0}, {"id": 117, "seek": 308811, "start": 3077.59, "end": 3088.11, "text": "انهاو الوقت قد انتهى، اكمل الاخر ثلاثة كلمات وانتقل إجابتك، شكرا جزيلا و أراك الشهر ان شاء الله", "tokens": [7649, 11296, 2407, 2423, 30543, 2655, 12174, 3215, 16472, 47395, 7578, 12399, 1975, 24793, 1211, 2423, 47283, 2288, 38637, 1211, 5718, 104, 3660, 9122, 19528, 9307, 4032, 7649, 2655, 4587, 1211, 11933, 7435, 16758, 2655, 4117, 12399, 13412, 4117, 23557, 10874, 11622, 1829, 15040, 4032, 5551, 23557, 4117, 25124, 3224, 2288, 16472, 13412, 16606, 21984], "avg_logprob": -0.5708705474223409, "compression_ratio": 1.4786324786324787, "no_speech_prob": 2.205371856689453e-06, "words": [{"start": 3077.59, "end": 3078.73, "word": "انهاو", "probability": 0.4824422200520833}, {"start": 3078.73, "end": 3079.15, "word": " الوقت", "probability": 0.778564453125}, {"start": 3079.15, "end": 3079.73, "word": " قد", "probability": 0.39459228515625}, {"start": 3079.73, "end": 3080.05, "word": " انتهى،", "probability": 0.7322998046875}, {"start": 3080.05, "end": 3080.61, "word": " اكمل", "probability": 0.6494954427083334}, {"start": 3080.61, "end": 3081.03, "word": " الاخر", "probability": 0.4793701171875}, {"start": 3081.03, "end": 3081.65, "word": " ثلاثة", "probability": 0.7227294921875}, {"start": 3081.65, "end": 3081.97, "word": " كلمات", "probability": 0.69921875}, {"start": 3081.97, "end": 3082.65, "word": " وانتقل", "probability": 0.567919921875}, {"start": 3082.65, "end": 3083.43, "word": " إجابتك،", "probability": 0.71002197265625}, {"start": 3083.43, "end": 3084.17, "word": " شكرا", "probability": 0.9326171875}, {"start": 3084.17, "end": 3084.69, "word": " جزيلا", "probability": 0.898193359375}, {"start": 3084.69, "end": 3085.87, "word": " و", "probability": 0.63427734375}, {"start": 3085.87, "end": 3086.67, "word": " أراك", "probability": 0.707763671875}, {"start": 3086.67, "end": 3087.33, "word": " الشهر", "probability": 0.4599812825520833}, {"start": 3087.33, "end": 3087.73, "word": " ان", "probability": 0.3115234375}, {"start": 3087.73, "end": 3088.05, "word": " شاء", "probability": 0.922607421875}, {"start": 3088.05, "end": 3088.11, "word": " الله", "probability": 0.9404296875}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 3090.274, "duration_after_vad": 2803.6193749999925}
\ No newline at end of file
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/jaTPlcCrh0Q_raw.srt b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/jaTPlcCrh0Q_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..b3a9e827ee4e1570c75d5fddd0b0f8d2d014bd6f
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/jaTPlcCrh0Q_raw.srt
@@ -0,0 +1,2244 @@
+1
+00:00:21,040 --> 00:00:28,100
+Good morning to you all. How are you? Can you
+
+2
+00:00:28,100 --> 00:00:31,040
+remind me what were we talking about last time?
+
+3
+00:00:32,260 --> 00:00:33,240
+Where did we stop?
+
+4
+00:00:36,100 --> 00:00:37,360
+Talking about?
+
+5
+00:00:39,920 --> 00:00:42,360
+Yes, she's speaking, please listen to her
+
+6
+00:00:46,020 --> 00:00:50,160
+Good little and a little few and a few good thank
+
+7
+00:00:50,160 --> 00:00:53,280
+you now what's the main difference between little
+
+8
+00:00:53,280 --> 00:00:59,320
+and a little as a group and few and a few as
+
+9
+00:00:59,320 --> 00:01:07,260
+another group yes pleasefew and a few we use with
+
+10
+00:01:07,260 --> 00:01:10,900
+count nouns okay good few and a few are used with
+
+11
+00:01:10,900 --> 00:01:15,260
+count nouns thank you little and a little with non
+
+12
+00:01:15,260 --> 00:01:17,860
+count nouns good thank you now what's the
+
+13
+00:01:17,860 --> 00:01:23,220
+difference between few and a few yes please few
+
+14
+00:01:23,220 --> 00:01:28,930
+used with negativenegative situations، negative
+
+15
+00:01:28,930 --> 00:01:33,490
+ideas، good، a few with positive, good، can you
+
+16
+00:01:33,490 --> 00:01:38,230
+give me an example؟
+
+17
+00:01:38,230 --> 00:01:45,690
+Now listen, if you students are absent nowوبدأنا
+
+18
+00:01:45,690 --> 00:01:50,930
+لذا يمكننا أن نبدأ لأن بعض الطلاب غير موجودين لم
+
+19
+00:01:50,930 --> 00:01:56,790
+يأتوا بعدها أكتر من الطلاب جاءوا لكن إذا لم يأتوا
+
+20
+00:01:56,790 --> 00:01:57,810
+بعض الطلاب
+
+21
+00:02:01,380 --> 00:02:04,460
+we can't start yes we should wait that's right
+
+22
+00:02:04,460 --> 00:02:08,840
+good yeah give me an example use few or a few in a
+
+23
+00:02:08,840 --> 00:02:14,580
+sentence in a situation yes please thank
+
+24
+00:02:14,580 --> 00:02:21,700
+you good another example okay now let's come to
+
+25
+00:02:21,700 --> 00:02:27,740
+little and a littleلطيب يستخدم قليلا مع حالات أو
+
+26
+00:02:27,740 --> 00:02:34,940
+فكرة و لطيب لطيب لطيب لطيب
+
+27
+00:02:34,940 --> 00:02:39,340
+لطيب لطيب لطيب لطيب لطيب لطيب لطيب لطيب لطيب لطيب
+
+28
+00:02:39,340 --> 00:02:40,980
+لطيب لطيب لطيب لطيب لطيب لطيب لطيب لطيب لطيب لطيب
+
+29
+00:02:40,980 --> 00:02:41,000
+لطيب لطيب لطيب لطيب لطيب لطيب لطيب لطيب لطيب لطيب
+
+30
+00:02:41,000 --> 00:02:41,020
+لطيب لطيب لطيب لطيب لطيب لطيب لطيب لطيب لطيب لطيب
+
+31
+00:02:41,020 --> 00:02:46,540
+لطيب لطيب لطيب لطيب لطيب لطيب لطيب
+
+32
+00:02:51,640 --> 00:02:56,560
+أكثر لتوضيح الفكرة أو المعنى، شكرا لك. الآن لدينا
+
+33
+00:02:56,560 --> 00:03:01,620
+تمرين هنا. أود أن تقوموا جميعًا بمشاركته. رقم 1،
+
+34
+00:03:01,620 --> 00:03:07,420
+نعم، أرجوك، اقرأ، اقرأه و أفعله. الوالد يتعب قليلا
+
+35
+00:03:07,420 --> 00:03:10,320
+في التعامل مع المدرسة العلوية. يبدو أنه يحب
+
+36
+00:03:10,320 --> 00:03:11,660
+التعامل مع التعامل مع المدرسة العلوية. على الأقل،
+
+37
+00:03:11,660 --> 00:03:14,900
+الوالد لديه بعض أصدقاء، بعض أصدقاء. حسنا، الآن،
+
+38
+00:03:14,900 --> 00:03:20,460
+انظر، هو يتعب.I just think is it a positive or a
+
+39
+00:03:20,460 --> 00:03:25,200
+negative situation؟ negative situation so we use
+
+40
+00:03:25,200 --> 00:03:30,220
+what؟ this we are talking about friends okay now
+
+41
+00:03:30,220 --> 00:03:35,420
+few is okay but what do you think of very few?very
+
+42
+00:03:35,420 --> 00:03:38,820
+few yeah it makes the meaning stronger write it
+
+43
+00:03:38,820 --> 00:03:43,740
+before thank you good very few very is written
+
+44
+00:03:43,740 --> 00:03:47,200
+between two brackets you know because you can say
+
+45
+00:03:47,200 --> 00:03:51,580
+very few it's a good sentence but to emphasize the
+
+46
+00:03:51,580 --> 00:03:54,180
+meaning to make the meaning stronger we use what
+
+47
+00:03:54,180 --> 00:03:58,800
+thank you yes pleasewe are looking forward to our
+
+48
+00:03:58,800 --> 00:04:01,840
+migration we are planning to spend a few days with
+
+49
+00:04:01,840 --> 00:04:05,100
+my folks and then a few days with my husband's
+
+50
+00:04:05,100 --> 00:04:09,300
+folks thank you why did you use a few because of
+
+51
+00:04:09,300 --> 00:04:13,900
+the situation good and we are talking about count
+
+52
+00:04:13,900 --> 00:04:20,580
+nouns thank you you are right next one yes please
+
+53
+00:04:20,580 --> 00:04:23,060
+come I was so hungry so I ate
+
+54
+00:04:26,090 --> 00:04:30,210
+فيو هل يمكنك أن تشرح لماذا استخدمت هذا الإجابة؟
+
+55
+00:04:30,210 --> 00:04:33,530
+إنها إجابة جيدة لكن لماذا استخدمتها؟ لأنها حالة
+
+56
+00:04:33,530 --> 00:04:37,170
+افضل و لا يمكننا التخطيط الآن هذا صحيح جيد اخر
+
+57
+00:04:37,170 --> 00:04:41,090
+واحد اخر واحد اخر اخر اخر اخر اخر اخر اخر اخر اخر
+
+58
+00:04:41,090 --> 00:04:41,130
+اخر اخر اخر اخر اخر اخر اخر اخر اخر اخر اخر اخر
+
+59
+00:04:41,130 --> 00:04:41,470
+اخر اخر اخر اخر اخر اخر اخر اخر اخر اخر اخر اخر
+
+60
+00:04:41,470 --> 00:04:45,290
+اخر اخر اخر اخر اخر اخر اخر اخر اخر اخر اخر اخر
+
+61
+00:04:45,290 --> 00:04:46,270
+اخر اخر اخر اخر اخر اخر اخر اخر اخر اخر اخر اخر
+
+62
+00:04:46,270 --> 00:04:47,270
+اخر اخر اخر اخر اخر اخر اخر اخر اخر اخر اخر اخر
+
+63
+00:04:47,270 --> 00:04:53,110
+اخر
+
+64
+00:04:53,110 --> 00:04:53,110
+اخر ا
+
+65
+00:04:59,380 --> 00:05:03,020
+والوالدين يجب أن يعملوا عملين كثيرين لذا لديهم ..
+
+66
+00:05:03,020 --> 00:05:07,120
+لديهم .. لديهم .. لديهم .. لديهم .. لديهم .. لديهم
+
+67
+00:05:07,120 --> 00:05:07,860
+.. لديهم .. لديهم .. لديهم .. لديهم .. لديهم ..
+
+68
+00:05:07,860 --> 00:05:09,620
+لديهم .. لديهم .. لديهم .. لديهم .. لديهم .. لديهم
+
+69
+00:05:09,620 --> 00:05:09,620
+.. لديهم .. لديهم .. لديهم .. لديهم .. لديهم ..
+
+70
+00:05:09,620 --> 00:05:10,500
+لديهم .. لديهم .. لديهم .. لديهم .. لديهم .. لديهم
+
+71
+00:05:10,500 --> 00:05:10,700
+.. لديهم .. لديهم .. لديهم .. لديهم .. لديهم ..
+
+72
+00:05:10,700 --> 00:05:10,760
+لديهم .. لديهم .. لديهم .. لديهم .. لديهم .. لديهم
+
+73
+00:05:10,760 --> 00:05:10,760
+.. لديهم .. لديهم .. لديهم .. لديهم .. لديهم ..
+
+74
+00:05:10,760 --> 00:05:24,920
+لديهم .. لديهم .. لديهم .. لديهم .. لديهم .. ل
+
+75
+00:05:26,290 --> 00:05:32,470
+just a minute yeah فضلي again
+
+76
+00:05:32,470 --> 00:05:37,090
+again it's
+
+77
+00:05:37,090 --> 00:05:40,590
+okay if you say few without very it's good it's a
+
+78
+00:05:40,590 --> 00:05:44,370
+good answer okay but you know you emphasize the
+
+79
+00:05:44,370 --> 00:05:47,350
+meaning you make the meaning stronger yes please
+
+80
+00:05:47,350 --> 00:05:48,150
+next one
+
+81
+00:05:58,830 --> 00:06:04,410
+Okay okay good what do you understand from this
+
+82
+00:06:04,410 --> 00:06:08,230
+proverb this is a famous saying in English okay
+
+83
+00:06:08,230 --> 00:06:14,700
+what does it mean yeah thank you yeahOkay, nothing
+
+84
+00:06:14,700 --> 00:06:17,400
+is perfect, there should be some troubles, okay?
+
+85
+00:06:18,040 --> 00:06:21,760
+Don't think that troubles are only in Gaza, okay?
+
+86
+00:06:21,840 --> 00:06:27,020
+Everywhere, everywhere, nothing is perfect, okay?
+
+87
+00:06:27,660 --> 00:06:29,400
+Next one، اتفضلي
+
+88
+00:06:43,720 --> 00:06:49,860
+she usually adds little or a little she likes
+
+89
+00:06:49,860 --> 00:06:54,740
+sweet to be sweet enough she needs a little okay
+
+90
+00:06:54,740 --> 00:07:04,740
+yeah okay
+
+91
+00:07:04,740 --> 00:07:08,000
+little milk thank you very much a little or a
+
+92
+00:07:08,000 --> 00:07:14,380
+littleهه a little a little good
+
+93
+00:07:42,770 --> 00:07:48,790
+الآن، انظروا إلى الاختصارات الجديدة، واحد،
+
+94
+00:07:48,790 --> 00:07:54,730
+كل واحد،
+
+95
+00:07:54,730 --> 00:07:55,890
+كل واحد، كل واحد، كل واحد، كل واحد، كل واحد، كل
+
+96
+00:07:55,890 --> 00:07:58,290
+واحد، كل واحد، كل واحد، كل واحد، كل واحد، كل واحد،
+
+97
+00:07:58,290 --> 00:07:58,290
+كل واحد، كل واحد، كل واحد، كل واحد، كل واحد، كل
+
+98
+00:07:58,290 --> 00:07:58,290
+واحد، كل واحد، كل واحد، كل واحد، كل واحد، كل واحد،
+
+99
+00:07:58,290 --> 00:07:58,310
+كل واحد، كل واحد، كل واحد، كل واحد، كل واحد، كل
+
+100
+00:07:58,310 --> 00:07:58,410
+واحد، كل واحد، كل واحد، كل واحد، كل واحد، كل واحد،
+
+101
+00:07:58,410 --> 00:07:58,530
+كل واحد، كل واحد، كل واحد، كل واحد، كل واحد، كل
+
+102
+00:07:58,530 --> 00:07:58,610
+واحد، كل واحد، كل واحد، كل واحد، كل واحد، كل واحد،
+
+103
+00:07:58,610 --> 00:08:00,950
+كل واحد، كل واحد، كل واحد، كل واحد، كل واحد، كل وا
+
+104
+00:08:01,240 --> 00:08:07,340
+one student one man one child one boy okay so they
+
+105
+00:08:07,340 --> 00:08:12,820
+are followed by what singular count nouns and what
+
+106
+00:08:12,820 --> 00:08:16,900
+type of verb a singular needs what a singular verb
+
+107
+00:08:16,900 --> 00:08:20,560
+a singular noun singular verb so every student
+
+108
+00:08:20,560 --> 00:08:27,840
+what haseach student has one student has don't use
+
+109
+00:08:27,840 --> 00:08:31,900
+a plural noun after any of these words okay
+
+110
+00:08:31,900 --> 00:08:37,460
+usually every student should study hard every
+
+111
+00:08:37,460 --> 00:08:44,370
+student is responsibleon herself and so on. So now
+
+112
+00:08:44,370 --> 00:08:48,670
+we have three expressions one each every are
+
+113
+00:08:48,670 --> 00:08:54,470
+followed by one singular nouns and singular verbs.
+
+114
+00:08:54,630 --> 00:09:01,270
+Good. Now look at the other groupThis is one of
+
+115
+00:09:01,270 --> 00:09:07,610
+the students. When I say one of it means I'm
+
+116
+00:09:07,610 --> 00:09:15,450
+talking about a group. So one of the studentseach
+
+117
+00:09:15,450 --> 00:09:19,310
+of the students or each one of the students every
+
+118
+00:09:19,310 --> 00:09:23,350
+one of the students remember the previous words
+
+119
+00:09:23,350 --> 00:09:28,050
+one each every this is one of the one of the each
+
+120
+00:09:28,050 --> 00:09:33,410
+of the and every one of the look they are followed
+
+121
+00:09:33,410 --> 00:09:36,550
+by what plural nouns but
+
+122
+00:09:39,800 --> 00:09:47,140
+عندما أقول أن واحد من الطلاب كان
+
+123
+00:09:47,140 --> 00:09:54,240
+فاطمة، خديجة، هودة وكذلك، أنا أتكلم عن واحد،
+
+124
+00:09:58,570 --> 00:10:02,950
+they are as you see followed by what plural count
+
+125
+00:10:02,950 --> 00:10:06,550
+nouns don't use any other nouns don't use singular
+
+126
+00:10:06,550 --> 00:10:13,950
+count don't use non count nouns look
+
+127
+00:10:13,950 --> 00:10:18,730
+at the two examples everyone and everyone what's
+
+128
+00:10:18,730 --> 00:10:21,990
+the difference between the two wordswho can tell
+
+129
+00:10:21,990 --> 00:10:25,970
+me خديجة everyone two words is an expression of
+
+130
+00:10:25,970 --> 00:10:29,490
+quantity okay this is one two words everyone
+
+131
+00:10:29,490 --> 00:10:34,850
+everyone okay yeah go on i have i have read every
+
+132
+00:10:34,850 --> 00:10:37,990
+one of those books yeah i have i have two books i
+
+133
+00:10:37,990 --> 00:10:40,450
+have read every one of those books i have read
+
+134
+00:10:40,450 --> 00:10:44,310
+this book and this book okay this is everyone so
+
+135
+00:10:44,310 --> 00:10:48,070
+again this is expression of quantity one is an
+
+136
+00:10:48,070 --> 00:10:51,830
+expression of a quantityyes go on this is what one
+
+137
+00:10:51,830 --> 00:10:56,830
+word this is one word what about that one word is
+
+138
+00:10:56,830 --> 00:11:00,370
+indefinite pronoun that's right indefinite pronoun
+
+139
+00:11:00,370 --> 00:11:04,610
+go on it has the same meaning of everybody yes
+
+140
+00:11:04,610 --> 00:11:10,990
+everybody should study hardeverybody okay has a
+
+141
+00:11:10,990 --> 00:11:15,510
+book for example everyone has a book yeah every
+
+142
+00:11:15,510 --> 00:11:19,030
+means everybody has a book yeah this is an example
+
+143
+00:11:19,030 --> 00:11:25,610
+now i have look everyone and everyone okay two
+
+144
+00:11:25,610 --> 00:11:29,350
+words and one word this is an expression of a
+
+145
+00:11:29,350 --> 00:11:33,770
+quantity and this is an yeah a pronoun
+
+146
+00:11:44,960 --> 00:11:45,640
+انتظر انتظر انتظر انتظر انتظر انتظر انتظر انتظر
+
+147
+00:11:45,640 --> 00:11:45,640
+انتظر انتظر انتظر انتظر انتظر انتظر انتظر انتظر
+
+148
+00:11:45,640 --> 00:11:45,640
+انتظر انتظر انتظر انتظر انتظر انتظر انتظر انتظر
+
+149
+00:11:45,640 --> 00:11:46,300
+انتظر انتظر انتظر انتظر انتظر انتظر انتظر انتظر
+
+150
+00:11:46,300 --> 00:11:46,300
+انتظر انتظر انتظر انتظر انتظر انتظر انتظر انتظر
+
+151
+00:11:46,300 --> 00:11:46,300
+انتظر انتظر انتظر انتظر انتظر انتظر انتظر انتظر
+
+152
+00:11:46,300 --> 00:12:00,720
+انتظر انتظر انتظر انتظر انتظر انتظر انتظر انتظر
+
+153
+00:12:03,770 --> 00:12:08,490
+Palestine is an everyday newspaper, we write it
+
+154
+00:12:08,490 --> 00:12:11,730
+one word, but I come to the university every day
+
+155
+00:12:11,730 --> 00:12:20,010
+with two words Now look each and every have the
+
+156
+00:12:20,010 --> 00:12:24,790
+same meaning Each is used when the speaker is
+
+157
+00:12:24,790 --> 00:12:29,330
+thinking of one person or thing at a time Now when
+
+158
+00:12:29,330 --> 00:12:33,710
+I say each student has a bookIt means this student
+
+159
+00:12:33,710 --> 00:12:37,430
+has, this student has, this student has and so on
+
+160
+00:12:37,430 --> 00:12:41,630
+.Each student has a book.Mary has a book and and
+
+161
+00:12:41,630 --> 00:12:44,890
+each one has a book.Every is used when the speaker
+
+162
+00:12:44,890 --> 00:12:49,530
+means all.Every student has a book it means all of
+
+163
+00:12:49,530 --> 00:12:53,630
+the students have books.Okay all of the students
+
+164
+00:12:53,630 --> 00:13:01,080
+.Now every student should study hard.is anybody
+
+165
+00:13:01,080 --> 00:13:07,040
+excluded؟ no it means all okay every student is
+
+166
+00:13:07,040 --> 00:13:11,780
+responsible for the result all the students okay
+
+167
+00:13:11,780 --> 00:13:16,800
+but when I say each student has a book each
+
+168
+00:13:16,800 --> 00:13:20,560
+student it means she has she has she has she has
+
+169
+00:13:20,560 --> 00:13:25,450
+I'm thinking of one studentليس من المجتمع ولكن
+
+170
+00:13:25,450 --> 00:13:30,950
+عندما أقول كل شيء انا أفكر في كل شيء. هذا صحيح.
+
+171
+00:13:31,930 --> 00:13:38,650
+هذا عملية. نريد أن نفعلها معًا. رقم واحد. نعم,
+
+172
+00:13:38,670 --> 00:13:43,750
+تعالي. ثم أنت. أستعد. نعم, تعالي.
+
+173
+00:13:47,250 --> 00:13:49,510
+تعالي. تعالي. نعم, أحفظ الوقت.
+
+174
+00:14:12,510 --> 00:14:18,230
+تفضلي اتفضلي اتفضلي اتفضلي اتفضلي اتفضلي اتفضلي
+
+175
+00:14:18,230 --> 00:14:24,150
+اتفضلي اتفضلي اتفضلي اتفضليطفل رقم 4 لأكل طفل، أنت
+
+176
+00:14:24,150 --> 00:14:28,450
+محق، شكرا، نعم، أرجوك، أنت أيضا، تعال، نعم، أنت
+
+177
+00:14:28,450 --> 00:14:38,110
+أيضا، ما هذا؟ لا تنظر يدي، أرجوك، حسنا، حسنا
+
+178
+00:14:51,490 --> 00:14:59,470
+7 و8 نعم أرجوك تعالوا أنت ايضا انتن
+
+179
+00:14:59,470 --> 00:15:12,010
+تعالوا أرجوك ايه انت تفعله رقم 7 نعم 1 اقرأه 1
+
+180
+00:15:12,010 --> 00:15:17,490
+طلاب انت محقة شكرا 1 طلاب جيد الأول
+
+181
+00:15:22,710 --> 00:15:29,370
+one of the students good and finally this is the
+
+182
+00:15:29,370 --> 00:15:35,210
+last one each
+
+183
+00:15:35,210 --> 00:15:39,010
+of each
+
+184
+00:15:39,010 --> 00:15:44,190
+student each student but this is each of
+
+185
+00:15:47,290 --> 00:15:56,170
+كل طلاب كل طلاب كل طلاب ماذا
+
+186
+00:15:56,170 --> 00:16:03,450
+فعلت؟ اه فعلت رقم 9 كل طلاب انت محق رقم 9 هذا
+
+187
+00:16:03,450 --> 00:16:09,310
+محدود انت محق نعم تعالي أرجوك ثم أنت ثم أنت ثم أنت
+
+188
+00:16:09,310 --> 00:16:09,730
+تعالي
+
+189
+00:16:19,250 --> 00:16:29,910
+student and each of the students good thank
+
+190
+00:16:29,910 --> 00:16:30,130
+you
+
+191
+00:16:42,960 --> 00:16:47,280
+الان اقوم بإصلاح الأخطاء .. اقوم بإصلاح الأخطاء ..
+
+192
+00:16:47,280 --> 00:16:52,480
+بعض السلسلات لا تحتوي على أي أخطاء ..الان أولا
+
+193
+00:16:52,480 --> 00:16:57,100
+دعونا نعرف الأخطاء في السلسلات .. رقم واحد اقرأ
+
+194
+00:16:57,100 --> 00:17:02,280
+أرجوك أين الأخطاء؟ أين الأخطاء؟ نعم رقم ثلاثة ..
+
+195
+00:17:02,280 --> 00:17:06,240
+رقم ثلاثة .. نعم الطالب .. الطالب أعطى كل طلاب
+
+196
+00:17:06,240 --> 00:17:14,130
+كتابة حساسة .. كل .. عندما نقرأه .. كل طلابNow so
+
+197
+00:17:14,130 --> 00:17:20,830
+this is the error each of the students how can we
+
+198
+00:17:20,830 --> 00:17:28,650
+how can we correct it can you just a minute this
+
+199
+00:17:28,650 --> 00:17:29,130
+is the error
+
+200
+00:17:35,720 --> 00:17:38,940
+Okay و this is you can say each of the students
+
+201
+00:17:38,940 --> 00:17:42,440
+that's right this is one way each of the students
+
+202
+00:17:42,440 --> 00:17:46,860
+او
+
+203
+00:17:46,860 --> 00:17:51,240
+او او او او او او او او او او او او او او او او او
+
+204
+00:17:51,240 --> 00:17:51,400
+او او او او او او او او او او او او او او او او او
+
+205
+00:17:51,400 --> 00:17:51,760
+او او او او او او او او او او او او او او او او او
+
+206
+00:17:51,760 --> 00:17:51,920
+او او او او او او او او او او او او او او او او او
+
+207
+00:17:51,920 --> 00:17:51,920
+او او او او او او او او او او او او او او او او او
+
+208
+00:17:51,920 --> 00:17:54,420
+او او او او او او او او او او او او او او او
+
+209
+00:17:58,900 --> 00:18:05,620
+الدكتورة محتاجة لكل واحد منهم؟ انه يقول انه يريدك
+
+210
+00:18:05,620 --> 00:18:09,600
+ان تقوم بتقليل الخطأ انا أعرف لكن انها مهمة لك نعم
+
+211
+00:18:09,600 --> 00:18:15,860
+بالطبع مع ذلك، ليست مقبلة بدون ذلك، لكل طلاب،
+
+212
+00:18:15,860 --> 00:18:20,400
+شكرا، تعالي، أرجوك، أين الخطأ؟
+
+213
+00:18:23,540 --> 00:18:31,360
+لا تغير اذا كنت بخير اذا كنت بخير اذا كنت بخير اذا
+
+214
+00:18:31,360 --> 00:18:31,980
+كنت بخير اذا كنت بخير اذا كنت بخير اذا كنت بخير
+
+215
+00:18:31,980 --> 00:18:32,940
+اذا كنت بخير اذا كنت بخير اذا كنت بخير اذا كنت
+
+216
+00:18:32,940 --> 00:18:37,560
+بخير اذا كنت بخير اذا كنت بخير اذا
+
+217
+00:18:37,560 --> 00:18:40,080
+كنت بخير
+
+218
+00:18:52,950 --> 00:18:57,150
+ماذا عن خمسة؟ اقرأها بفضل الله لا تغير اقرأ خمسة
+
+219
+00:18:57,150 --> 00:19:01,530
+اقرأ خمسة و افعلها إسبانيا هو واحدة من البلدين
+
+220
+00:19:01,530 --> 00:19:05,670
+اللي اعرفها واحدة من البلدين جيد جدا واحدة من
+
+221
+00:19:05,670 --> 00:19:13,030
+البلدين شكرا رقم ستة رقم ستة اه تعالي بفضل الله
+
+222
+00:19:24,630 --> 00:19:30,310
+just a minute just a minute just a minute yes
+
+223
+00:19:30,310 --> 00:19:35,710
+where is the error where is the error furniture
+
+224
+00:19:35,710 --> 00:19:36,310
+okay
+
+225
+00:19:38,730 --> 00:19:43,930
+الوضع هو كلمة غير موجودة والكل يستخدمها مع كل
+
+226
+00:19:43,930 --> 00:19:53,930
+طلاب، كل سيارة، كل يوم وما إلى ذلك، كل الوضع، هذا
+
+227
+00:19:53,930 --> 00:20:04,810
+خطأ، كتابة الوضع، تخططه، تخططه، كتابة
+
+228
+00:20:04,810 --> 00:20:06,290
+الوضع، تخططه، تخططه، تخططه، تخططه، تخططه، تخططه،
+
+229
+00:20:06,290 --> 00:20:06,310
+تخططه، تخططه، تخططه، تخططه، تخططه، تخططه، تخططه،
+
+230
+00:20:06,310 --> 00:20:06,310
+تخططه، تخططه، تخططه، تخططه، تخططه، تخططه، تخططه،
+
+231
+00:20:06,310 --> 00:20:09,420
+تخططه، تخططه، تخططه، تخطhow can I make it singular
+
+232
+00:20:09,420 --> 00:20:13,600
+you know every
+
+233
+00:20:13,600 --> 00:20:17,540
+piece of .. this is one way thank you thank you
+
+234
+00:20:17,540 --> 00:20:23,620
+write it write it there at the end every piece of
+
+235
+00:20:23,620 --> 00:20:28,520
+furniture
+
+236
+00:20:28,520 --> 00:20:31,780
+just a minute
+
+237
+00:20:39,770 --> 00:20:45,950
+furniture write furniture now another way we can
+
+238
+00:20:45,950 --> 00:20:50,770
+say a lot of furniture we can now you know you
+
+239
+00:20:50,770 --> 00:20:53,290
+cannot say you can you know you don't we don't
+
+240
+00:20:53,290 --> 00:20:57,050
+want to change everything we want to change the
+
+241
+00:20:57,050 --> 00:21:01,990
+error this is the error furniture okay so we can
+
+242
+00:21:01,990 --> 00:21:08,050
+use it in another way yeahشكرا جزيلا كيف نستخدمها
+
+243
+00:21:08,050 --> 00:21:13,690
+بطريقة أخرى نستخدمها بطريقة أخرى نستخدمها بطريقة
+
+244
+00:21:13,690 --> 00:21:15,310
+أخرى نستخدمها بطريقة أخرى نستخدمها بطريقة أخرى
+
+245
+00:21:15,310 --> 00:21:19,330
+نستخدمها بطريقة أخرى نستخدمها بطريقة أخرى نستخدمها
+
+246
+00:21:19,330 --> 00:21:19,670
+بطريقة أخرى نستخدمها بطريقة أخرى نستخدمها بطريقة
+
+247
+00:21:19,670 --> 00:21:21,090
+أخرى نستخدمها بطريقة أخرى نستخدمها بطريقة أخرى
+
+248
+00:21:21,090 --> 00:21:23,590
+نستخدمها بطريقة أخرى نستخدمها بطريقة أخرى نستخدمها
+
+249
+00:21:23,590 --> 00:21:25,250
+بطريقة أخرى نستخدمها بطريقة أخرى نستخدمها بطريقة
+
+250
+00:21:25,250 --> 00:21:33,310
+أخرى نستخدمها
+
+251
+00:21:33,310 --> 00:21:40,680
+بطريقة أخرإذا قلت على سبيل المثال كل من .. هل
+
+252
+00:21:40,680 --> 00:21:46,240
+يمكنني أن أقول كل من الوضع؟ كل
+
+253
+00:21:46,240 --> 00:21:47,920
+من كل من كل من كل من كل من كل من كل من كل من كل من
+
+254
+00:21:47,920 --> 00:21:50,140
+كل من كل من كل من كل من كل من كل من كل من كل من كل
+
+255
+00:21:50,140 --> 00:21:52,220
+من
+
+256
+00:22:02,700 --> 00:22:09,300
+أنت محق أنا أجلس نحن قمنا بتغييرها لذا نريد أن
+
+257
+00:22:09,300 --> 00:22:14,980
+ننظر مرة أخرى لإجابتك ماذا كانت إجابتك؟ أكتر من
+
+258
+00:22:14,980 --> 00:22:16,880
+أكتر من أكتر من أكتر من أكتر من أكتر من أكتر من
+
+259
+00:22:16,880 --> 00:22:17,560
+أكتر من أكتر من أكتر من أكتر من أكتر من أكتر من
+
+260
+00:22:17,560 --> 00:22:17,880
+أكتر من أكتر من أكتر من أكتر من أكتر من أكتر من
+
+261
+00:22:17,880 --> 00:22:19,100
+أكتر من أكتر من أكتر من أكتر من أكتر من أكتر من
+
+262
+00:22:19,100 --> 00:22:23,220
+أكتر من أكتر من أكتر من أكتر من أكتر من أكتر من
+
+263
+00:22:23,220 --> 00:22:35,050
+أكتر من أكتر من أكتر منأكتر من .. و أستطيع أن أقول
+
+264
+00:22:35,050 --> 00:22:43,650
+كل المصنع بدون .. أستطيع أن أقول كل المصنع؟ نعم،
+
+265
+00:22:43,650 --> 00:22:46,750
+فهذه طريقة أخرى
+
+266
+00:22:52,930 --> 00:23:00,470
+كل المطبخ، كل مطبخ، كل قطعة المطبخ، نعم لكنك تقول
+
+267
+00:23:00,470 --> 00:23:03,350
+اننا لا نستطيع تغيير كل مطبخ؟ لذا قمنا بتغييره،
+
+268
+00:23:03,350 --> 00:23:09,170
+نحن نتحدث عن نفس الإجابة، حسنًا؟ نستطيع أن
+
+269
+00:23:09,170 --> 00:23:11,710
+نستخدمها، نعرف ذلك، لكن .. نستطيع .. نستطيع ..
+
+270
+00:23:11,710 --> 00:23:12,470
+نستطيع .. نستطيع .. نستطيع .. نستطيع .. نستطيع ..
+
+271
+00:23:12,470 --> 00:23:12,830
+نستطيع .. نستطيع .. نستطيع .. نستطيع .. نستطيع ..
+
+272
+00:23:12,830 --> 00:23:12,990
+نستطيع .. نستطيع .. نستطيع .. نستطيع .. نستطيع ..
+
+273
+00:23:12,990 --> 00:23:13,390
+نستطيع .. نستطيع .. نستطيع .. نستطيع .. نستطيع ..
+
+274
+00:23:13,390 --> 00:23:14,930
+نستطيع .. نستطيع .. نستطيع .. نستطيع
+
+275
+00:23:20,860 --> 00:23:24,080
+السلسلة التالية رقم سبتمبر سبتمبر سبتمبر سبتمبر
+
+276
+00:23:24,080 --> 00:23:26,160
+سبتمبر سبتمبر سبتمبر سبتمبر سبتمبر سبتمبر سبتمبر
+
+277
+00:23:26,160 --> 00:23:30,320
+سبتمبر سبتمبر سبتمبر سبتمبر سبتمبر سبتمبر سبتمبر
+
+278
+00:23:30,320 --> 00:23:36,120
+سبتمبر سبتمبر سبتمبر
+
+279
+00:23:36,120 --> 00:23:36,580
+سبتمبر سبتمبر سبتمبر سبتمبر سبتمبر سبتمبر سبتمبر
+
+280
+00:23:36,580 --> 00:23:36,600
+سبتمبر سبتمبر سبتمبر سبتمبر سبتمبر سبتمبر سبتمبر
+
+281
+00:23:36,600 --> 00:23:36,600
+سبتمبر سبتمبر سبتمبر سبتمبر سبتمبر سبتمبر سبتمبر
+
+282
+00:23:36,600 --> 00:23:36,720
+سبتمبر سبتمبر سبتمبر سبتمبر سبتمبر سبتمبر سبتمبر
+
+283
+00:23:36,720 --> 00:23:42,940
+سبتمبر سبتمبر سبتمبر سبتمبر
+
+284
+00:23:42,940 --> 00:23:45,340
+س
+
+285
+00:23:56,500 --> 00:24:02,100
+نقول انها بعض من .. هذا صحيح انها اجابة جيدة بعض
+
+286
+00:24:02,100 --> 00:24:08,220
+منها .. اكملها بعض من الأجهزة .. اكتبها .. اكملها
+
+287
+00:24:08,220 --> 00:24:16,110
+نريد أن نبحث عن اجابة أخرى بعض من الأجهزةلا لا لا
+
+288
+00:24:16,110 --> 00:24:17,130
+لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا
+
+289
+00:24:17,130 --> 00:24:17,330
+لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا
+
+290
+00:24:17,330 --> 00:24:17,330
+لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا
+
+291
+00:24:17,330 --> 00:24:19,950
+لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا
+
+292
+00:24:19,950 --> 00:24:24,690
+لا لا لا لا لا لا لا لا لا
+
+293
+00:24:24,690 --> 00:24:25,070
+لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا
+
+294
+00:24:25,070 --> 00:24:27,170
+لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا
+
+295
+00:24:27,170 --> 00:24:27,170
+لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا
+
+296
+00:24:27,170 --> 00:24:29,370
+لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا
+
+297
+00:24:29,370 --> 00:24:32,570
+لا لا
+
+298
+00:24:32,570 --> 00:24:32,570
+لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا
+
+299
+00:24:32,570 --> 00:24:32,590
+لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا
+
+300
+00:24:32,590 --> 00:24:32,590
+لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا
+
+301
+00:24:32,590 --> 00:24:32,910
+لا لا لا لا لا لا لا لا لا لا لا لا لا لا لا
+
+302
+00:24:47,950 --> 00:24:54,290
+one of the machines or can I use piece yeah what
+
+303
+00:24:54,290 --> 00:24:58,250
+shall I say piece of equipment who is the speaker
+
+304
+00:24:58,250 --> 00:25:06,330
+piece or a piece can I say book can I say I read
+
+305
+00:25:06,330 --> 00:25:12,390
+book I ate sandwich no so you have to say a piece
+
+306
+00:25:12,390 --> 00:25:14,730
+can we say a little equipment
+
+307
+00:25:19,220 --> 00:25:25,660
+بسبب أننا نريد نتكلم عن واحدة قليل لا يعني واحدة
+
+308
+00:25:25,660 --> 00:25:31,360
+لايعني واحدة فأحد
+
+309
+00:25:31,360 --> 00:25:37,220
+الأجهزة في مكتبنا محطمة نستخدم
+
+310
+00:25:37,220 --> 00:25:43,240
+بعضها نستخدم بعضها يعني نفس المعنى طريقة أخرى نريد
+
+311
+00:25:43,240 --> 00:25:47,220
+أن نستخدم السلام ما كان جوابك؟
+
+312
+00:26:08,190 --> 00:26:14,210
+أو نستطيع أيضًا نقول واحد من
+
+313
+00:26:37,740 --> 00:26:43,590
+ماذا تريد أن تقول يا ياسمين؟عندما تقول sum of one
+
+314
+00:26:43,590 --> 00:26:53,270
+of the sum of نعم، برمجية مقبلة، نعم لأن sum يعني
+
+315
+00:26:53,270 --> 00:26:59,190
+جزء و one يعني جزء، في هذا الوضع إنه قمم، لذلك
+
+316
+00:26:59,190 --> 00:27:04,110
+لديك أكثر من واحدة إجابة، رقم ماذا الآن؟ رقم 8،
+
+317
+00:27:04,110 --> 00:27:08,930
+رقم 8، نعم بفضل الله، قم بقراهاI gave a present to
+
+318
+00:27:08,930 --> 00:27:15,990
+each of the women in the room okay so I gave a
+
+319
+00:27:15,990 --> 00:27:19,810
+present to each of the woman in the room where is
+
+320
+00:27:19,810 --> 00:27:24,430
+the error woman okay thank you this is the error
+
+321
+00:27:24,430 --> 00:27:28,870
+how can I correct it women thank you very much
+
+322
+00:27:41,540 --> 00:27:52,140
+الان يمكنني اقول تفكر في مجلة اخرى تفكر
+
+323
+00:27:52,140 --> 00:28:01,560
+في مجلة اخرى كل واحدة من المرأة كل واحدة من المرأة
+
+324
+00:28:01,560 --> 00:28:05,220
+كل واحدة من المرأة
+
+325
+00:28:12,180 --> 00:28:18,660
+all all of the women all of the women yeah this is
+
+326
+00:28:18,660 --> 00:28:23,080
+another answer teacher each means that I think in
+
+327
+00:28:23,080 --> 00:28:30,460
+one person at the time no if they all and every
+
+328
+00:28:30,460 --> 00:28:34,400
+means what all but each that I think in one person
+
+329
+00:28:34,400 --> 00:28:36,420
+in this sense you are right but again
+
+330
+00:28:36,420 --> 00:28:40,430
+grammatically it is acceptedgramatically it is
+
+331
+00:28:40,430 --> 00:28:44,590
+accepted next
+
+332
+00:28:44,590 --> 00:28:57,590
+one number nine yes number nine come
+
+333
+00:28:57,590 --> 00:28:59,150
+please and wait
+
+334
+00:29:11,000 --> 00:29:20,840
+number ten number ten place is
+
+335
+00:29:20,840 --> 00:29:24,840
+good number
+
+336
+00:29:24,840 --> 00:29:31,180
+ten تفضلي no change you are right come and write
+
+337
+00:29:31,180 --> 00:29:32,700
+it no change
+
+338
+00:29:47,290 --> 00:29:51,230
+it's impossible for one human being to know every
+
+339
+00:29:51,230 --> 00:29:56,410
+languages in the world to know every languages,
+
+340
+00:29:56,730 --> 00:30:01,270
+every language, good come and do it and finally
+
+341
+00:30:01,270 --> 00:30:06,810
+the last one I found each of the errors in this
+
+342
+00:30:06,810 --> 00:30:11,030
+exercise, errors, good I found each of the errors
+
+343
+00:30:23,750 --> 00:30:27,570
+Each of their roles. Can you give another answer
+
+344
+00:30:27,570 --> 00:30:32,550
+for the last one? Each of their roles. Yes, good.
+
+345
+00:30:32,890 --> 00:30:37,010
+Write it. Thank you. Each error.
+
+346
+00:30:47,320 --> 00:30:48,720
+الان التجربة القادمة
+
+347
+00:31:16,700 --> 00:31:23,640
+نكمل التعليم مع رقم او ازرار رقم ا ا ا ا ا ا ا ا ا
+
+348
+00:31:23,640 --> 00:31:24,380
+ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا
+
+349
+00:31:24,380 --> 00:31:25,880
+ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا
+
+350
+00:31:25,880 --> 00:31:26,720
+ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا
+
+351
+00:31:26,720 --> 00:31:26,820
+ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا
+
+352
+00:31:26,820 --> 00:31:26,820
+ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا
+
+353
+00:31:26,820 --> 00:31:26,820
+ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا
+
+354
+00:31:26,820 --> 00:31:26,820
+ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا
+
+355
+00:31:26,820 --> 00:31:26,820
+ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا ا
+
+356
+00:31:33,960 --> 00:31:38,860
+thank you you are right next one yes come please
+
+357
+00:31:38,860 --> 00:31:48,380
+several of good next one yeah come okay
+
+358
+00:31:48,380 --> 00:31:54,180
+several of your students good yeah next one most
+
+359
+00:31:54,180 --> 00:31:58,480
+of your students good next one good come most of
+
+360
+00:31:58,480 --> 00:32:01,580
+them I know
+
+361
+00:32:13,190 --> 00:32:16,570
+أنا أعرف الكثير من هؤلاء الطلاب أعرف الكثير من
+
+362
+00:32:16,570 --> 00:32:18,050
+هؤلاء، شكرا، تعال
+
+363
+00:32:27,860 --> 00:32:43,360
+أنا أعرف الكثير منهم أعرف
+
+364
+00:32:43,360 --> 00:32:47,180
+الكثير منهم
+
+365
+00:32:47,710 --> 00:32:54,310
+I know a lot of yes a lot of a lot of students
+
+366
+00:32:54,310 --> 00:33:01,850
+yeah next one yes
+
+367
+00:33:01,850 --> 00:33:12,610
+come oh
+
+368
+00:33:12,610 --> 00:33:17,130
+sorry I changed it go on oh
+
+369
+00:33:19,300 --> 00:33:25,580
+None of them
+
+370
+00:33:25,580 --> 00:33:31,500
+and
+
+371
+00:33:31,500 --> 00:33:37,720
+finally none of them
+
+372
+00:33:55,450 --> 00:34:02,550
+الأن، انظر إلى التعليم، انظر إلى التعليم، عدة طلاب
+
+373
+00:34:02,550 --> 00:34:08,570
+عدة طلاب الطلاب و
+
+374
+00:34:08,570 --> 00:34:14,500
+عدة طلاب طلابكmost of you the students most of
+
+375
+00:34:14,500 --> 00:34:18,160
+them now what's the difference between several of
+
+376
+00:34:18,160 --> 00:34:21,160
+the students and several students do you think
+
+377
+00:34:21,160 --> 00:34:24,840
+there is a difference between them yeah and
+
+378
+00:34:24,840 --> 00:34:28,120
+several students it's not a specific very good now
+
+379
+00:34:28,120 --> 00:34:32,660
+when i say several students okay several people
+
+380
+00:34:32,660 --> 00:34:35,580
+are sitting at home are having a holiday today
+
+381
+00:34:35,580 --> 00:34:40,220
+right it is saturdayseveral students are absent
+
+382
+00:34:40,220 --> 00:34:43,860
+several students this is general not specific and
+
+383
+00:34:43,860 --> 00:34:50,440
+when I say when I say several of the students I'm
+
+384
+00:34:50,440 --> 00:34:54,200
+talking about specific group of the students okay
+
+385
+00:34:54,200 --> 00:34:57,900
+several of the students so this is specific and
+
+386
+00:34:57,900 --> 00:35:03,210
+this is what general not specificagain several of
+
+387
+00:35:03,210 --> 00:35:09,450
+your students and several of them when do we use
+
+388
+00:35:09,450 --> 00:35:15,910
+ofshe said we use of when we are talking about
+
+389
+00:35:15,910 --> 00:35:20,010
+specific, when the noun is specific and when we
+
+390
+00:35:20,010 --> 00:35:25,150
+have you .. you .. them .. those .. them .. those
+
+391
+00:35:25,150 --> 00:35:29,190
+.. them .. yeah this is what a pronoun very good
+
+392
+00:35:29,190 --> 00:35:33,950
+so again we use of yeah can you summarize
+
+393
+00:35:41,720 --> 00:35:51,680
+Good thank you very much I bought one book and I
+
+394
+00:35:51,680 --> 00:35:56,220
+bought what many books now with some expressions
+
+395
+00:35:56,220 --> 00:36:01,200
+of a quantity of is not used when the noun is what
+
+396
+00:36:01,200 --> 00:36:08,480
+okay now I bought one bookI bought what? many
+
+397
+00:36:08,480 --> 00:36:12,980
+books. We don't use what. Of is not used when the
+
+398
+00:36:12,980 --> 00:36:17,960
+noun is non-specific. Many books. A group of
+
+399
+00:36:17,960 --> 00:36:23,740
+books. This is general. Now one book. It can be
+
+400
+00:36:23,740 --> 00:36:28,480
+any book. Did I identify the book? So the noun is
+
+401
+00:36:28,480 --> 00:36:34,440
+not specific, is non-specific. Of is not used.look
+
+402
+00:36:34,440 --> 00:36:37,860
+at the other group one of those books when I say
+
+403
+00:36:37,860 --> 00:36:42,040
+those books those students those pens I'm talking
+
+404
+00:36:42,040 --> 00:36:46,600
+about a specific group of okay some of the books
+
+405
+00:36:46,600 --> 00:36:51,740
+many of the my books most of them so it's used
+
+406
+00:36:51,740 --> 00:36:56,700
+with what they express specific nouns so any
+
+407
+00:36:56,700 --> 00:37:01,710
+pronouns of is used withspecific nouns and
+
+408
+00:37:01,710 --> 00:37:06,670
+pronouns okay and when we have general nouns we
+
+409
+00:37:06,670 --> 00:37:11,070
+don't use of I have a lot of books is this
+
+410
+00:37:11,070 --> 00:37:17,390
+specific no okay I have read a lot of those books
+
+411
+00:37:17,390 --> 00:37:21,850
+when I say look those books those books this is a
+
+412
+00:37:21,850 --> 00:37:25,890
+specific noun right but books this is non-specific
+
+413
+00:37:25,890 --> 00:37:32,200
+so even though we used ofof is a part of the
+
+414
+00:37:32,200 --> 00:37:39,000
+expression okay we cannot say I have a lot box for
+
+415
+00:37:39,000 --> 00:37:42,980
+example so it is a part of the expression we use
+
+416
+00:37:42,980 --> 00:37:50,160
+of even though we have non-specific nouns so yeah
+
+417
+00:37:50,160 --> 00:37:55,810
+read pleaseexpressions of a quantity like a lot of
+
+418
+00:37:55,810 --> 00:38:00,270
+always include of whether the noun in time
+
+419
+00:38:00,270 --> 00:38:04,590
+specific or specific that's right a lot of this is
+
+420
+00:38:04,590 --> 00:38:08,330
+one of the expressions we are we don't mind
+
+421
+00:38:08,330 --> 00:38:11,630
+whether the noun is specific or not specific we
+
+422
+00:38:11,630 --> 00:38:16,530
+should use of okay so in general of is used with
+
+423
+00:38:16,530 --> 00:38:20,990
+pronouns and with specific nounsExcept in some
+
+424
+00:38:20,990 --> 00:38:26,930
+expressions like a lot of why
+
+425
+00:38:26,930 --> 00:38:33,070
+we can say I have a lot of box a lot we have lots
+
+426
+00:38:33,070 --> 00:38:38,990
+of box you can say it is not used a lot you say a
+
+427
+00:38:38,990 --> 00:38:42,990
+lot of or you say lots of but a lot alone is not
+
+428
+00:38:42,990 --> 00:38:47,130
+used in English okay we say a lot of box or lots
+
+429
+00:38:47,130 --> 00:38:48,790
+of box okay
+
+430
+00:38:51,820 --> 00:38:56,820
+ماذا هي الاختصارات الواقعية؟ لقد ذكرنا الاختصارات
+
+431
+00:38:56,820 --> 00:39:02,160
+الواقعية دعونا نرى بسرعة الاختصارات الواقعية، يا
+
+432
+00:39:02,160 --> 00:39:10,800
+قوم قوم قوم قوم قوم قوم قوم قوم
+
+433
+00:39:10,900 --> 00:39:15,540
+thank you so they are و expressions of a quantity
+
+434
+00:39:15,540 --> 00:39:18,940
+they can be used with some of them with of and
+
+435
+00:39:18,940 --> 00:39:24,670
+some without you know one you can say oneone man
+
+436
+00:39:24,670 --> 00:39:29,510
+came one of the men came okay or but you say half
+
+437
+00:39:29,510 --> 00:39:33,390
+of this is necessary to use okay fifty percent of
+
+438
+00:39:33,390 --> 00:39:38,610
+this is necessary to use sometimes you can delete
+
+439
+00:39:38,610 --> 00:39:41,150
+it you can use the expression without of and
+
+440
+00:39:41,150 --> 00:39:44,910
+sometimes you should use it yeah yes please go on
+
+441
+00:39:51,830 --> 00:39:55,650
+Thank you they are expressions of quantity you
+
+442
+00:39:55,650 --> 00:39:58,410
+know when it is between brackets it means it can
+
+443
+00:39:58,410 --> 00:40:06,750
+be omitted and finally the last one good
+
+444
+00:40:06,750 --> 00:40:09,590
+and you know some of them is used with count
+
+445
+00:40:09,590 --> 00:40:13,010
+others with non count other with plural you know
+
+446
+00:40:13,010 --> 00:40:18,570
+that we talked about this beforeهذا مجرد مجرد مجرد
+
+447
+00:40:18,570 --> 00:40:19,750
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+448
+00:40:19,750 --> 00:40:25,710
+مجرد مجرد
+
+449
+00:40:25,710 --> 00:40:29,310
+مجرد
+
+450
+00:40:51,360 --> 00:40:57,620
+most students are hard working good yes come some
+
+451
+00:40:57,620 --> 00:41:01,660
+of the students in this case class are little lazy
+
+452
+00:41:01,660 --> 00:41:09,640
+some of the students good come please a lot of
+
+453
+00:41:09,640 --> 00:41:16,220
+mail good next one a lot of mail I get junk mail
+
+454
+00:41:16,220 --> 00:41:22,210
+okay it's junk mail good comea lot of mail yes
+
+455
+00:41:22,210 --> 00:41:45,330
+please which one number seven most box good it is
+
+456
+00:41:45,330 --> 00:41:48,590
+specific good we are talking about علي's box good
+
+457
+00:41:49,210 --> 00:41:52,350
+يا كام؟ كام كام؟ I bought a few box كام كام؟ I
+
+458
+00:41:52,350 --> 00:41:54,770
+bought a few box كام كام؟ I bought a few box كام
+
+459
+00:41:54,770 --> 00:41:54,810
+كام؟ I bought a few box كام كام؟ I bought a few
+
+460
+00:41:54,810 --> 00:41:56,070
+box كام كام؟ I bought a few box كام كام؟ I bought
+
+461
+00:41:56,070 --> 00:41:56,070
+a few box كام كام؟ I bought a few box كام كام؟ I
+
+462
+00:41:56,070 --> 00:41:56,070
+bought a few box كام كام؟ I bought a few box كام
+
+463
+00:41:56,070 --> 00:41:56,070
+كام؟ I bought a few box كام كام؟ I bought a few
+
+464
+00:41:56,070 --> 00:41:56,070
+box كام كام؟ I bought a few box كام كام؟ I bought
+
+465
+00:41:56,070 --> 00:41:56,110
+a few box كام كام؟ I bought a few box كام كام؟ I
+
+466
+00:41:56,110 --> 00:41:56,110
+bought a few box كام كام؟ I bought a few box كام
+
+467
+00:41:56,110 --> 00:41:58,310
+كام؟ I bought a few box كام كام؟ I bought a few
+
+468
+00:41:58,310 --> 00:42:02,910
+box كام كام؟ I bought a few box كام كام؟ I bought
+
+469
+00:42:02,910 --> 00:42:16,470
+a few box كام كام؟ I bought a few
+
+470
+00:42:16,470 --> 00:42:21,370
+boxماذا تفعل؟ انا جديد، حسنًا، رقم 11، نعم، اذهب
+
+471
+00:42:21,370 --> 00:42:26,350
+إلى هنا، نعم، انها زرع، قوم تقرأها، انا جديد هنا،
+
+472
+00:42:26,350 --> 00:42:39,370
+انا جديد، انا لا اعرف المال، جيد، شكرا، انا جديد،
+
+473
+00:42:39,370 --> 00:42:42,430
+انا لا اعرف المال، جيد، انا جديد، انا جديد، انا
+
+474
+00:42:42,430 --> 00:42:42,430
+جديد، انا جديد، انا جديد، انا جديد، انا جديد، انا
+
+475
+00:42:42,430 --> 00:42:42,850
+جديد، انا جديد، انا جديد، انا جديد، انا جديد، انا
+
+476
+00:42:42,850 --> 00:42:43,630
+جديد، انا جديد، انا جديد، انا جديد، انا جديد، انا
+
+477
+00:42:43,630 --> 00:42:50,130
+جديد، انا جديد، انا جديد، انا جديد، اmillions of
+
+478
+00:42:50,130 --> 00:43:08,650
+people correct
+
+479
+00:43:08,650 --> 00:43:17,850
+the errors again what's on correct
+
+480
+00:43:17,850 --> 00:43:23,140
+the errorsنمبر واحد .. نعم قرأ نمبر واحد و اكتشف
+
+481
+00:43:23,140 --> 00:43:35,820
+الخطأ حسنًا،
+
+482
+00:43:35,820 --> 00:43:36,660
+هذا الكتاب
+
+483
+00:43:46,130 --> 00:43:53,310
+many different wait
+
+484
+00:43:53,310 --> 00:43:59,390
+please many different now where is the error
+
+485
+00:43:59,390 --> 00:44:03,270
+identify the error underline the error first of
+
+486
+00:44:03,270 --> 00:44:06,850
+all just a minute she can clean clean clean clean
+
+487
+00:44:06,850 --> 00:44:09,630
+what you wrote this is one good another error
+
+488
+00:44:12,970 --> 00:44:19,610
+look story good this is another error and just a
+
+489
+00:44:19,610 --> 00:44:25,190
+minute look at the beginning that book that book
+
+490
+00:44:25,190 --> 00:44:30,930
+contains so لأ keep it it is okay it's okay
+
+491
+00:44:30,930 --> 00:44:37,910
+contains
+
+492
+00:44:37,910 --> 00:44:38,170
+yeah
+
+493
+00:44:52,300 --> 00:44:56,960
+Good thank you very much Now listen when you join
+
+494
+00:44:56,960 --> 00:45:02,250
+a group of words with andThere should be a certain
+
+495
+00:45:02,250 --> 00:45:06,450
+sequence. Now we are using nouns. You use
+
+496
+00:45:06,450 --> 00:45:14,350
+singular, pen, a comma, a pen, comma, a book and a
+
+497
+00:45:14,350 --> 00:45:17,370
+bag for example. Singular, singular and singular.
+
+498
+00:45:17,970 --> 00:45:20,630
+Since you started with a plural, you should use
+
+499
+00:45:20,630 --> 00:45:27,770
+plural and plural. Number two. سُهَر Read it. In
+
+500
+00:45:27,770 --> 00:45:31,030
+my country there is a lot of schools.there is a
+
+501
+00:45:31,030 --> 00:45:34,310
+lot of schools where is the error yes good
+
+502
+00:45:34,310 --> 00:45:42,030
+corrected there
+
+503
+00:45:42,030 --> 00:45:46,850
+are good thank you next one ياسمين she is always
+
+504
+00:45:46,850 --> 00:45:49,610
+willing to help her friends in every possible ways
+
+505
+00:45:49,610 --> 00:45:54,450
+in every possible way you are right thank you in
+
+506
+00:45:54,450 --> 00:45:56,010
+every possible way good
+
+507
+00:45:59,350 --> 00:46:07,790
+القادة التالية رقم 4 ناجوة نعم رقم 4 رقم 4 رقم 4
+
+508
+00:46:07,790 --> 00:46:09,670
+رقم 4 رقم 4 رقم 4 رقم 4 رقم 4 رقم 4 رقم 4 رقم 4
+
+509
+00:46:09,670 --> 00:46:10,010
+رقم 4 رقم 4 رقم 4 رقم 4 رقم 4 رقم 4 رقم 4 رقم 4
+
+510
+00:46:10,010 --> 00:46:10,010
+رقم 4 رقم 4 رقم 4 رقم 4 رقم 4 رقم 4 رقم 4 رقم 4
+
+511
+00:46:10,010 --> 00:46:12,850
+رقم 4 رقم 4 رقم 4 رقم 4 رقم 5 رقم 5 رقم 5 رقم 5
+
+512
+00:46:12,850 --> 00:46:16,670
+رقم 5 رقم 5 رقم 5 رقم 5 رقم 5 رقم 5 رقم 5 رقم 5
+
+513
+00:46:16,670 --> 00:46:21,190
+رقم 5 رقم 5 رقم 5 رقم 5 رقم 5 رقم 5 رقم 5 رقم 5
+
+514
+00:46:21,190 --> 00:46:25,310
+رقم
+
+515
+00:46:28,430 --> 00:46:34,890
+means very good you are right thank you number
+
+516
+00:46:34,890 --> 00:46:44,450
+five yes armies good
+
+517
+00:46:44,450 --> 00:46:54,030
+thank you write it next one yeah come please there
+
+518
+00:46:54,030 --> 00:47:09,380
+are a lot ofOkay write it read
+
+519
+00:47:09,380 --> 00:47:15,820
+it there are equipment a lot of there are a lot of
+
+520
+00:47:15,820 --> 00:47:21,800
+equipment so we use there are or there is there is
+
+521
+00:47:21,800 --> 00:47:30,520
+good there isthank you next one okay let's
+
+522
+00:47:30,520 --> 00:47:34,440
+complete the exercise seven yes teacher yes come
+
+523
+00:47:34,440 --> 00:47:37,780
+please read it i have five years old daughter and
+
+524
+00:47:37,780 --> 00:47:46,020
+three years old son where
+
+525
+00:47:46,020 --> 00:47:50,400
+is
+
+526
+00:47:50,400 --> 00:47:54,000
+the error hyphen
+
+527
+00:47:54,000 --> 00:47:54,960
+okay
+
+528
+00:48:11,680 --> 00:48:19,180
+Thank you now listen this is okay this is a noun
+
+529
+00:48:19,180 --> 00:48:24,260
+right and this is a noun modifier it modifies the
+
+530
+00:48:24,260 --> 00:48:28,120
+noun when we use numbers with the noun modifier we
+
+531
+00:48:28,120 --> 00:48:33,000
+should hyphen we use which the modifier should be
+
+532
+00:48:33,000 --> 00:48:41,020
+hyphenated again okay a three this is sunanother
+
+533
+00:48:41,020 --> 00:48:48,000
+noun so we the modifier should be hyphenated next
+
+534
+00:48:48,000 --> 00:49:00,340
+one number seven come please come where
+
+535
+00:49:00,340 --> 00:49:03,460
+is
+
+536
+00:49:03,460 --> 00:49:08,300
+the error first of all is look
+
+537
+00:49:10,540 --> 00:49:14,660
+Okay now we are talking about most of the people
+
+538
+00:49:14,660 --> 00:49:20,360
+most of the people are you are right corrected
+
+539
+00:49:20,360 --> 00:49:31,260
+most of the people are not is yeah yeah
+
+540
+00:49:31,260 --> 00:49:34,200
+what about the other words look apartments
+
+541
+00:49:34,200 --> 00:49:42,080
+building apartments buildingأه أه أه أه أه أه أه
+
+542
+00:49:42,080 --> 00:49:42,740
+أه أه أه أه أه أه أه أه أه أه أه أه أه أه أه أه أه
+
+543
+00:49:42,740 --> 00:49:51,560
+أه أه أه أه أه أه أه أه
+
+544
+00:49:51,560 --> 00:49:55,260
+أه أه أه أه أه أه أه أه أه أه أه أه أه أه أه أه أه
+
+545
+00:49:55,260 --> 00:49:58,600
+أه أه أه أه أه أه أه أه أه أه أه أه أه أه أه أه أه
+
+546
+00:50:03,170 --> 00:50:09,630
+thank you a good answer most of this
+
+547
+00:50:09,630 --> 00:50:15,870
+is number eight most of the people yes most of the
+
+548
+00:50:15,870 --> 00:50:18,630
+people you are right good most of the people in
+
+549
+00:50:18,630 --> 00:50:26,570
+because we are talking about specific noun number
+
+550
+00:50:26,570 --> 00:50:34,160
+seven what about number sevensorry between the two
+
+551
+00:50:34,160 --> 00:50:38,580
+words between I
+
+552
+00:50:38,580 --> 00:50:42,600
+have three words so the hyphen is written between
+
+553
+00:50:42,600 --> 00:50:46,480
+the words I have three words I can write two
+
+554
+00:50:46,480 --> 00:50:50,840
+hyphens okay
+
+555
+00:50:52,450 --> 00:50:57,430
+نعم عندما نستخدم الرقم مع التغيير ، لذلك هذه
+
+556
+00:50:57,430 --> 00:51:03,990
+التعبيرة عندما أقول خمس سنة عمرها تتغيير الليل ،
+
+557
+00:51:03,990 --> 00:51:08,650
+لذلك يجب أن يكون الليل التغيير حيفنية إذا استخدمت
+
+558
+00:51:08,650 --> 00:51:12,770
+الحفن بين الكلمات ، لذلك الآن لدي ثلاث كلمات
+
+559
+00:51:12,770 --> 00:51:15,810
+يأخذون ماذا يأخذون
+
+560
+00:51:17,590 --> 00:51:21,970
+انهاو الوقت قد انتهى، اكمل الاخر ثلاثة كلمات
+
+561
+00:51:21,970 --> 00:51:28,110
+وانتقل إجابتك، شكرا جزيلا و أراك الشهر ان شاء الله
+
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/l2mLxQ5yDp4_raw.json b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/l2mLxQ5yDp4_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..c00c65390ebbea65d770d90512e0edbe557ef883
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/l2mLxQ5yDp4_raw.json
@@ -0,0 +1 @@
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So again in spoken English, the present perfect helping verbs, they are contracted. Okay, they are reduced as we saw in these examples. Note in very informal writing, has is sometimes contracted with nouns. Has also. 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point in time we said far and since", "tokens": [3424, 281, 855, 264, 2896, 291, 2864, 281, 257, 2121, 281, 257, 1629, 935, 294, 565, 321, 848, 1400, 293, 1670], "avg_logprob": -0.369318195364692, "compression_ratio": 1.2025316455696202, "no_speech_prob": 0.0, "words": [{"start": 2302.27, "end": 2302.61, "word": "just", "probability": 0.05029296875}, {"start": 2302.61, "end": 2302.87, "word": " to", "probability": 0.87548828125}, {"start": 2302.87, "end": 2303.11, "word": " show", "probability": 0.9521484375}, {"start": 2303.11, "end": 2303.25, "word": " the", "probability": 0.79443359375}, {"start": 2303.25, "end": 2303.65, "word": " period", "probability": 0.97265625}, {"start": 2303.65, "end": 2303.87, "word": " you", "probability": 0.58984375}, {"start": 2303.87, "end": 2304.35, "word": " refer", "probability": 0.82373046875}, {"start": 2304.35, "end": 2304.63, "word": " to", "probability": 0.9619140625}, {"start": 2304.63, "end": 2304.79, "word": " a", "probability": 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2566.64, "end": 2595.86, "text": "simple past in a specific time but we use present perfect when we finish a specific time thank you very much yes please complete it happened and finished or completed thank you very much and finally we use present perfect to ask about actions that happened or not", "tokens": [30937, 781, 1791, 294, 257, 2685, 565, 457, 321, 764, 1974, 2176, 562, 321, 2413, 257, 2685, 565, 1309, 291, 588, 709, 2086, 1767, 3566, 309, 2011, 293, 4335, 420, 7365, 1309, 291, 588, 709, 293, 2721, 321, 764, 1974, 2176, 281, 1029, 466, 5909, 300, 2011, 420, 406], "avg_logprob": -0.35593749821186066, "compression_ratio": 1.8920863309352518, "no_speech_prob": 1.1920928955078125e-06, "words": [{"start": 2566.6400000000003, "end": 2567.26, "word": "simple", "probability": 0.5218353271484375}, {"start": 2567.26, "end": 2567.72, "word": " past", "probability": 0.775390625}, {"start": 2567.72, "end": 2568.44, "word": " in", "probability": 0.923828125}, {"start": 2568.44, "end": 2568.6, "word": " a", "probability": 0.861328125}, {"start": 2568.6, "end": 2568.88, "word": " specific", "probability": 0.947265625}, {"start": 2568.88, "end": 2569.4, "word": " time", "probability": 0.91552734375}, {"start": 2569.4, "end": 2569.92, "word": " but", "probability": 0.7177734375}, {"start": 2569.92, "end": 2570.12, "word": " we", "probability": 0.93701171875}, {"start": 2570.12, "end": 2570.42, "word": " use", "probability": 0.87939453125}, {"start": 2570.42, "end": 2570.86, "word": " present", "probability": 0.75244140625}, {"start": 2570.86, "end": 2571.28, "word": " perfect", "probability": 0.9453125}, {"start": 2571.28, "end": 2571.6, "word": " when", "probability": 0.9013671875}, {"start": 2571.6, "end": 2571.74, "word": " we", "probability": 0.6123046875}, {"start": 2571.74, "end": 2571.96, "word": " finish", "probability": 0.1689453125}, {"start": 2571.96, "end": 2572.14, "word": " a", "probability": 0.6416015625}, {"start": 2572.14, "end": 2572.32, "word": " specific", "probability": 0.83837890625}, {"start": 2572.32, "end": 2572.56, "word": " time", "probability": 0.69482421875}, {"start": 2572.56, "end": 2572.98, "word": " thank", "probability": 0.578125}, {"start": 2572.98, "end": 2573.12, "word": " you", "probability": 0.92919921875}, {"start": 2573.12, "end": 2573.32, "word": " very", "probability": 0.86767578125}, {"start": 2573.32, "end": 2573.64, "word": " much", "probability": 0.93115234375}, {"start": 2573.64, "end": 2573.88, "word": " yes", "probability": 0.7763671875}, {"start": 2573.88, "end": 2574.38, "word": " please", "probability": 0.828125}, {"start": 2574.38, "end": 2582.56, "word": " complete", "probability": 0.07861328125}, {"start": 2582.56, "end": 2588.36, "word": " it", "probability": 0.447509765625}, {"start": 2588.36, "end": 2588.78, "word": " happened", "probability": 0.65771484375}, {"start": 2588.78, "end": 2589.22, "word": " and", "probability": 0.9326171875}, {"start": 2589.22, "end": 2589.7, "word": " finished", "probability": 0.8349609375}, {"start": 2589.7, "end": 2589.96, "word": " or", "probability": 0.9033203125}, {"start": 2589.96, "end": 2590.4, "word": " completed", "probability": 0.7275390625}, {"start": 2590.4, "end": 2590.68, "word": " thank", "probability": 0.82080078125}, {"start": 2590.68, "end": 2590.8, "word": " you", "probability": 0.97216796875}, {"start": 2590.8, "end": 2590.98, "word": " very", "probability": 0.8642578125}, {"start": 2590.98, "end": 2591.18, "word": " much", "probability": 0.91845703125}, {"start": 2591.18, "end": 2591.34, "word": " and", "probability": 0.95458984375}, {"start": 2591.34, "end": 2591.94, "word": " finally", "probability": 0.90673828125}, {"start": 2591.94, "end": 2592.38, "word": " we", "probability": 0.5458984375}, {"start": 2592.38, "end": 2592.74, "word": " use", "probability": 0.798828125}, {"start": 2592.74, "end": 2593.02, "word": " present", "probability": 0.8564453125}, {"start": 2593.02, "end": 2593.44, "word": " perfect", "probability": 0.919921875}, {"start": 2593.44, "end": 2593.72, "word": " to", "probability": 0.8525390625}, {"start": 2593.72, "end": 2593.92, "word": " ask", "probability": 0.92919921875}, {"start": 2593.92, "end": 2594.22, "word": " about", "probability": 0.70947265625}, {"start": 2594.22, "end": 2594.7, "word": " actions", "probability": 0.82861328125}, {"start": 2594.7, "end": 2595.06, "word": " that", "probability": 0.93115234375}, {"start": 2595.06, "end": 2595.42, "word": " happened", "probability": 0.80615234375}, {"start": 2595.42, "end": 2595.7, "word": " or", "probability": 0.400146484375}, {"start": 2595.7, "end": 2595.86, "word": " not", "probability": 0.76513671875}], "temperature": 1.0}, {"id": 101, "seek": 261882, "start": 2596.32, "end": 2618.82, "text": "Okay whether they have happened, have you ever visited, have you ever seen, have you ever driven and so on Okay thank you very much, now please do the exercises at home, keep your questions for the next time okay Mark all the difficult points to be discussed in the next lecture, thank you very much", "tokens": [8297, 1968, 436, 362, 2011, 11, 362, 291, 1562, 11220, 11, 362, 291, 1562, 1612, 11, 362, 291, 1562, 9555, 293, 370, 322, 1033, 1309, 291, 588, 709, 11, 586, 1767, 360, 264, 11900, 412, 1280, 11, 1066, 428, 1651, 337, 264, 958, 565, 1392, 3934, 439, 264, 2252, 2793, 281, 312, 7152, 294, 264, 958, 7991, 11, 1309, 291, 588, 709], "avg_logprob": -0.22110614890143984, "compression_ratio": 1.7183908045977012, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 2596.32, "end": 2596.74, "word": "Okay", "probability": 0.09576416015625}, {"start": 2596.74, "end": 2597.48, "word": " whether", "probability": 0.380859375}, {"start": 2597.48, "end": 2597.78, "word": " they", "probability": 0.91796875}, {"start": 2597.78, "end": 2598.04, "word": " have", "probability": 0.8095703125}, {"start": 2598.04, "end": 2598.46, "word": " happened,", "probability": 0.845703125}, {"start": 2598.62, "end": 2598.72, "word": " have", "probability": 0.89990234375}, {"start": 2598.72, "end": 2598.86, "word": " you", "probability": 0.97412109375}, {"start": 2598.86, "end": 2599.12, "word": " ever", "probability": 0.86865234375}, {"start": 2599.12, "end": 2599.48, "word": " visited,", "probability": 0.95361328125}, {"start": 2599.76, "end": 2599.92, "word": " have", "probability": 0.94970703125}, {"start": 2599.92, "end": 2600.04, "word": " you", "probability": 0.97509765625}, {"start": 2600.04, "end": 2600.3, "word": " ever", "probability": 0.89306640625}, {"start": 2600.3, "end": 2600.64, "word": " seen,", "probability": 0.92822265625}, {"start": 2601.08, "end": 2601.24, "word": " have", "probability": 0.947265625}, {"start": 2601.24, "end": 2601.38, "word": " you", "probability": 0.97412109375}, {"start": 2601.38, "end": 2601.78, "word": " ever", "probability": 0.9072265625}, {"start": 2601.78, "end": 2602.58, "word": " driven", "probability": 0.96728515625}, {"start": 2602.58, "end": 2603.18, "word": " and", "probability": 0.76513671875}, {"start": 2603.18, "end": 2603.34, "word": " so", "probability": 0.94970703125}, {"start": 2603.34, "end": 2603.58, "word": " on", "probability": 0.96044921875}, {"start": 2603.58, "end": 2604.22, "word": " Okay", "probability": 0.2734375}, {"start": 2604.22, "end": 2604.5, "word": " thank", "probability": 0.68994140625}, {"start": 2604.5, "end": 2604.64, "word": " you", "probability": 0.9658203125}, {"start": 2604.64, "end": 2604.8, "word": " very", "probability": 0.87744140625}, {"start": 2604.8, "end": 2605.02, "word": " much,", "probability": 0.92626953125}, {"start": 2605.1, "end": 2605.24, "word": " now", "probability": 0.89501953125}, {"start": 2605.24, "end": 2605.62, "word": " please", "probability": 0.79345703125}, {"start": 2605.62, "end": 2605.88, "word": " do", "probability": 0.94580078125}, {"start": 2605.88, "end": 2606.06, "word": " the", "probability": 0.912109375}, {"start": 2606.06, "end": 2606.74, "word": " exercises", "probability": 0.94921875}, {"start": 2606.74, "end": 2607.06, "word": " at", "probability": 0.9765625}, {"start": 2607.06, "end": 2607.4, "word": " home,", "probability": 0.880859375}, {"start": 2607.9, "end": 2608.14, "word": " keep", "probability": 0.91455078125}, {"start": 2608.14, "end": 2608.34, "word": " your", "probability": 0.8896484375}, {"start": 2608.34, "end": 2608.82, "word": " questions", "probability": 0.85107421875}, {"start": 2608.82, "end": 2609.16, "word": " for", "probability": 0.95654296875}, {"start": 2609.16, "end": 2609.3, "word": " the", "probability": 0.9111328125}, {"start": 2609.3, "end": 2609.5, "word": " next", "probability": 0.939453125}, {"start": 2609.5, "end": 2609.88, "word": " time", "probability": 0.88427734375}, {"start": 2609.88, "end": 2610.96, "word": " okay", "probability": 0.4853515625}, {"start": 2610.96, "end": 2612.98, "word": " Mark", "probability": 0.658203125}, {"start": 2612.98, "end": 2613.38, "word": " all", "probability": 0.95458984375}, {"start": 2613.38, "end": 2613.56, "word": " the", "probability": 0.9169921875}, {"start": 2613.56, "end": 2614.02, "word": " difficult", "probability": 0.9296875}, {"start": 2614.02, "end": 2614.6, "word": " points", "probability": 0.91650390625}, {"start": 2614.6, "end": 2616.16, "word": " to", "probability": 0.95849609375}, {"start": 2616.16, "end": 2616.34, "word": " be", "probability": 0.9521484375}, {"start": 2616.34, "end": 2616.86, "word": " discussed", "probability": 0.888671875}, {"start": 2616.86, "end": 2617.08, "word": " in", "probability": 0.95703125}, {"start": 2617.08, "end": 2617.2, "word": " the", "probability": 0.927734375}, {"start": 2617.2, "end": 2617.38, "word": " next", "probability": 0.9453125}, {"start": 2617.38, "end": 2617.8, "word": " lecture,", "probability": 0.94677734375}, {"start": 2617.98, "end": 2618.16, "word": " thank", "probability": 0.8369140625}, {"start": 2618.16, "end": 2618.26, "word": " you", 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\ No newline at end of file
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/l2mLxQ5yDp4_raw.srt b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/l2mLxQ5yDp4_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..f1b9aadc47f5f1b96f533ad54bc7d0151b62afd5
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/l2mLxQ5yDp4_raw.srt
@@ -0,0 +1,2128 @@
+1
+00:00:20,860 --> 00:00:29,500
+مرحباً لكم جميعًا كيف حالك اليوم؟
+
+2
+00:00:29,500 --> 00:00:33,520
+بخير شكرا هل
+
+3
+00:00:33,520 --> 00:00:39,740
+يمكنك أن تقرأ قصة سجة؟ شكرا
+
+4
+00:00:39,740 --> 00:00:46,000
+جزيلا ممتاز ممتاز وممتاز وممتاز ممتاز هو معنى
+
+5
+00:00:46,000 --> 00:00:52,190
+ممتاز لدينا اثنين نوع من الممتازsimple and
+
+6
+00:00:52,190 --> 00:00:57,650
+progressive as we will see now when I tell you
+
+7
+00:00:57,650 --> 00:01:07,430
+that I have taught English since 1984 again I have
+
+8
+00:01:07,430 --> 00:01:12,570
+taught English since 1984 what do you understand
+
+9
+00:01:12,570 --> 00:01:16,790
+what do you understand yes please
+
+10
+00:01:21,260 --> 00:01:26,200
+very good thank you very much the action started
+
+11
+00:01:26,200 --> 00:01:35,320
+since a point in time and still and still now can
+
+12
+00:01:35,320 --> 00:01:38,400
+you read this sentence نجوة can you read it is it
+
+13
+00:01:38,400 --> 00:01:38,780
+clear
+
+14
+00:01:43,980 --> 00:01:48,300
+very good has been a teacher is she still teaching
+
+15
+00:01:48,300 --> 00:01:56,700
+thank you دعا read the other one thank
+
+16
+00:01:56,700 --> 00:02:00,760
+you very much are you still living in that city
+
+17
+00:02:00,760 --> 00:02:03,740
+according to the sentence thank you Nada read this
+
+18
+00:02:03,740 --> 00:02:09,750
+one please are you still herethank you read the
+
+19
+00:02:09,750 --> 00:02:22,890
+other one please دعاء thank
+
+20
+00:02:22,890 --> 00:02:30,510
+you very much has none have none okay have none
+
+21
+00:02:30,510 --> 00:02:34,030
+and has none and finally yeah
+
+22
+00:02:37,120 --> 00:02:40,800
+thank you very much good can you talk about
+
+23
+00:02:40,800 --> 00:02:43,880
+yourself can you give me examples about yourself
+
+24
+00:02:43,880 --> 00:02:49,220
+like that I have been studying
+
+25
+00:02:49,220 --> 00:02:51,680
+it is a good sentence but we want to use this
+
+26
+00:02:51,680 --> 00:02:54,880
+tense I have been studying you use the progressive
+
+27
+00:02:54,880 --> 00:02:57,920
+another tense thank you very much good it's a good
+
+28
+00:02:57,920 --> 00:03:01,620
+sentence yeah give me another tell me about your
+
+29
+00:03:01,620 --> 00:03:05,860
+universityإذا كنت تريد أن تخبرني أن أتكلم عن
+
+30
+00:03:05,860 --> 00:03:15,100
+مدرستك، ماذا تقول؟ استخدم الفعل الـ join I انا قد
+
+31
+00:03:15,100 --> 00:03:20,140
+قمت بمشاركة المدرسة منذ سبتمبر، شكرا جزيلا جزيلا
+
+32
+00:03:20,140 --> 00:03:23,740
+لك، أنا قد قمت بمشاركة المدرسة منذ سبتمبر
+
+33
+00:03:27,850 --> 00:03:34,970
+we as you see since last may or for three years I
+
+34
+00:03:34,970 --> 00:03:40,790
+have taught English since 1984 I have taught
+
+35
+00:03:40,790 --> 00:03:48,510
+English for 30 years for 30 years what's the
+
+36
+00:03:48,510 --> 00:03:52,030
+difference between for and since yeah
+
+37
+00:03:59,390 --> 00:04:04,890
+Okay thank you very much thank you if you look at
+
+38
+00:04:04,890 --> 00:04:11,710
+the sentence nine o'clock does it show a point in
+
+39
+00:04:11,710 --> 00:04:17,510
+time or a period of time point in time good thank
+
+40
+00:04:17,510 --> 00:04:24,470
+you now for three yearsانها تشير لوقت طويل، انها
+
+41
+00:04:24,470 --> 00:04:31,090
+تشير لوقت طويل، انها
+
+42
+00:04:31,090 --> 00:04:35,210
+تشير لوقت طويل، انها تشير لوقت طويل، انها تشير
+
+43
+00:04:35,210 --> 00:04:35,250
+لوقت طويل، انها تشير لوقت طويل، انها تشير لوقت
+
+44
+00:04:35,250 --> 00:04:35,810
+طويل، انها تشير لوقت طويل، انها تشير لوقت طويل،
+
+45
+00:04:35,810 --> 00:04:35,810
+انها تشير لوقت طويل، انها تشير لوقت طويل، انها
+
+46
+00:04:35,810 --> 00:04:35,810
+تشير لوقت طويل، انها تشير لوقت طويل، انها تشير
+
+47
+00:04:35,810 --> 00:04:36,210
+لوقت طويل، انها تشير لوقت طويل، انها تشير لوقت
+
+48
+00:04:36,210 --> 00:04:40,590
+طويل، انها تشير لوقت طويل، انها تشير لوقت طويل،
+
+49
+00:04:40,590 --> 00:04:44,890
+انها تشير لوقت
+
+50
+00:04:45,300 --> 00:04:49,200
+and continue up to now thank you to talk about
+
+51
+00:04:49,200 --> 00:04:53,360
+look it is a present tense it is present perfect
+
+52
+00:04:53,360 --> 00:04:59,280
+but it is used to talk about actions okay happened
+
+53
+00:04:59,280 --> 00:05:04,680
+when began in the past they started in the past up
+
+54
+00:05:04,680 --> 00:05:09,640
+to now started in the past up to now yeah thank
+
+55
+00:05:09,640 --> 00:05:13,840
+you very much go on please situation
+
+56
+00:05:15,190 --> 00:05:21,650
+What is the situation in this sentence? Being a
+
+57
+00:05:21,650 --> 00:05:27,010
+teacher. Thank you. The time frame up to now.
+
+58
+00:05:27,510 --> 00:05:32,150
+Thank you. Now as you see since is used with a
+
+59
+00:05:32,150 --> 00:05:36,770
+specific point in time and again for is used with
+
+60
+00:05:36,770 --> 00:05:43,240
+a length with a length a period of time2 سنة، 5
+
+61
+00:05:43,240 --> 00:05:51,100
+ساعة، 1 أسبوع وكذلك قم بقراءة السلسلة الأخرى، من
+
+62
+00:05:51,100 --> 00:05:53,540
+يستطيع القراءة السلسلة الأخرى مرة أخرى؟ أنا لم
+
+63
+00:05:53,540 --> 00:05:59,290
+أعرف أولا منذ أن كنت في الجامعة شكرا جزيلاsince I
+
+64
+00:05:59,290 --> 00:06:05,910
+was in high school when have I known علا since I
+
+65
+00:06:05,910 --> 00:06:11,070
+was if you look at since I was this is a time
+
+66
+00:06:11,070 --> 00:06:15,750
+clause we use since we can use it to begin a time
+
+67
+00:06:15,750 --> 00:06:21,170
+clauseFollowed by a subject and a verb again. I
+
+68
+00:06:21,170 --> 00:06:24,690
+want you to talk about yourself Using the present
+
+69
+00:06:24,690 --> 00:06:28,550
+perfect to show an action started in the past and
+
+70
+00:06:28,550 --> 00:06:35,490
+still going on Very
+
+71
+00:06:35,490 --> 00:06:39,670
+good.
+
+72
+00:06:39,790 --> 00:06:45,130
+I have lived. Thank you very much Present perfect,
+
+73
+00:06:45,350 --> 00:06:45,650
+please
+
+74
+00:06:48,830 --> 00:06:56,450
+I was reading .. I was reading .. I was reading ..
+
+75
+00:06:56,450 --> 00:07:01,110
+I was reading .. I was reading .. I was reading ..
+
+76
+00:07:01,110 --> 00:07:02,990
+I was reading .. I was reading .. I was reading ..
+
+77
+00:07:02,990 --> 00:07:04,550
+I was reading .. I was reading .. I was reading ..
+
+78
+00:07:04,550 --> 00:07:05,010
+I was reading .. I was reading .. I was reading ..
+
+79
+00:07:05,010 --> 00:07:05,410
+I was reading .. I was reading .. I was reading ..
+
+80
+00:07:05,410 --> 00:07:05,650
+I was reading .. I was reading .. I was reading ..
+
+81
+00:07:05,650 --> 00:07:06,350
+I was reading .. I was reading .. I was reading ..
+
+82
+00:07:06,350 --> 00:07:06,350
+I was reading .. I was reading .. I was reading ..
+
+83
+00:07:06,350 --> 00:07:06,350
+I was reading .. I was reading .. I was reading ..
+
+84
+00:07:06,350 --> 00:07:06,350
+I was reading .. I was reading .. I was reading ..
+
+85
+00:07:06,350 --> 00:07:06,350
+I was reading .. I was reading .. I was reading ..
+
+86
+00:07:06,350 --> 00:07:06,350
+I was reading .. I was reading .. I was reading ..
+
+87
+00:07:06,350 --> 00:07:06,350
+I was reading .. I was reading .. I was reading ..
+
+88
+00:07:06,350 --> 00:07:06,390
+I was reading .. I was reading .. I was reading ..
+
+89
+00:07:06,390 --> 00:07:06,430
+I was reading .. I was reading .. I was reading ..
+
+90
+00:07:06,430 --> 00:07:06,430
+I was reading .. I was reading .. I was reading ..
+
+91
+00:07:06,430 --> 00:07:10,770
+I was reading .. I was reading .. I was reading ..
+
+92
+00:07:10,770 --> 00:07:13,050
+I was reading .. I was reading ..
+
+93
+00:07:18,160 --> 00:07:21,860
+very good I have known here since I was at school
+
+94
+00:07:21,860 --> 00:07:27,320
+I known here since I was thank you my dad my dad
+
+95
+00:07:27,320 --> 00:07:29,860
+has worked in the college since I was a child
+
+96
+00:07:29,860 --> 00:07:33,080
+thank you very much is he still working very good
+
+97
+00:07:33,080 --> 00:07:36,620
+thank you yeah I have gone to camp since 2009
+
+98
+00:07:36,620 --> 00:07:42,280
+thank you very much yes please okay
+
+99
+00:07:42,280 --> 00:07:45,940
+thank
+
+100
+00:07:45,940 --> 00:07:53,490
+you very much good yeahI have met many people
+
+101
+00:07:53,490 --> 00:07:57,790
+since I came to the university since I came here
+
+102
+00:07:57,790 --> 00:08:06,830
+thank you very much good now have you ever seen a
+
+103
+00:08:06,830 --> 00:08:16,710
+lion دعاء no I haven't no I haven't have you ever
+
+104
+00:08:16,710 --> 00:08:25,890
+visitedمكة لأ لأ لأ لأ لأ
+
+105
+00:08:25,890 --> 00:08:30,450
+لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ
+
+106
+00:08:30,450 --> 00:08:30,630
+لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ
+
+107
+00:08:30,630 --> 00:08:30,630
+لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ
+
+108
+00:08:30,630 --> 00:08:30,630
+لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ
+
+109
+00:08:30,630 --> 00:08:30,790
+لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ
+
+110
+00:08:30,790 --> 00:08:32,370
+لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ
+
+111
+00:08:32,370 --> 00:08:41,670
+لأ لأ لأ
+
+112
+00:08:41,670 --> 00:08:43,230
+ل
+
+113
+00:08:51,980 --> 00:08:55,680
+have or haven't happened okay you can say yes i
+
+114
+00:08:55,680 --> 00:09:00,320
+have no i haven't no i haven't it has never
+
+115
+00:09:00,320 --> 00:09:04,080
+happened yes i have it did would you please read
+
+116
+00:09:04,080 --> 00:09:08,360
+the example okay read please read the sentence
+
+117
+00:09:08,360 --> 00:09:16,900
+thank you very much so i'm asking about whether
+
+118
+00:09:16,900 --> 00:09:26,450
+somethingهل حدث قبل الان او لا ؟ الان عندما أسألك
+
+119
+00:09:26,450 --> 00:09:34,170
+هل قد رحلت اي سيارة؟ هل قمت بتصميم الوقت؟ هل قمت
+
+120
+00:09:34,170 --> 00:09:40,370
+بتحدث عن فترة من الوقت في الماضي؟ هل الوقت مهم
+
+121
+00:09:40,370 --> 00:09:45,530
+الان؟ لا قم بقراءة الفرصة الأخرى أرجوك
+
+122
+00:09:51,290 --> 00:09:55,570
+thank you very much look at these adverbs ever
+
+123
+00:09:55,570 --> 00:10:01,190
+never yet still already they are usually used with
+
+124
+00:10:01,190 --> 00:10:06,780
+the present perfectemphasize the meaning to give
+
+125
+00:10:06,780 --> 00:10:10,700
+us a certain meaning I haven't finished you
+
+126
+00:10:10,700 --> 00:10:14,640
+understand what that the action is not completed
+
+127
+00:10:14,640 --> 00:10:18,020
+but when you add yet it gives strength to the
+
+128
+00:10:18,020 --> 00:10:22,260
+meaning okay you understand still already have
+
+129
+00:10:22,260 --> 00:10:26,960
+ever and never another we use now the present
+
+130
+00:10:26,960 --> 00:10:34,450
+perfect also to talk about yeahممكن تحدث عن حدث او
+
+131
+00:10:34,450 --> 00:10:36,570
+حدث حدث حدث حدث حدث حدث حدث حدث حدث حدث حدث حدث
+
+132
+00:10:36,570 --> 00:10:38,510
+حدث حدث حدث حدث حدث حدث حدث حدث حدث حدث حدث حدث
+
+133
+00:10:38,510 --> 00:10:40,190
+حدث حدث حدث حدث حدث حدث حدث حدث حدث حدث حدث حدث
+
+134
+00:10:40,190 --> 00:10:41,290
+حدث حدث حدث حدث حدث حدث حدث حدث حدث حدث حدث حدث
+
+135
+00:10:41,290 --> 00:10:41,910
+حدث حدث حدث حدث حدث حدث حدث حدث حدث حدث حدث حدث
+
+136
+00:10:41,910 --> 00:10:46,690
+حدث حدث حدث حدث حدث حدث حدث حدث حدث
+
+137
+00:10:46,690 --> 00:10:50,210
+حدث حدث
+
+138
+00:11:12,730 --> 00:11:19,230
+والوقت غير محدد وليس مهم نحن لسنا مهتمين بالوقت
+
+139
+00:11:19,230 --> 00:11:24,870
+عندما أقول نحن حصلنا على ثلاث تجارب حتى الآن
+
+140
+00:11:28,870 --> 00:11:35,190
+I have given you ten lectures so far this term I
+
+141
+00:11:35,190 --> 00:11:41,250
+have given what do you understand I have given did
+
+142
+00:11:41,250 --> 00:11:47,610
+we stopأو هل قمنا بالإعطاء دراسات؟ لأ لقد أعطينا
+
+143
+00:11:47,610 --> 00:11:53,070
+اليوم الأول مرره في اليوم الثاني مرره مرره مرره
+
+144
+00:11:53,070 --> 00:11:54,970
+مرره مرره مرره مرره مرره مرره مرره مرره مرره مرره
+
+145
+00:11:54,970 --> 00:11:55,110
+مرره مرره مرره مرره مرره مرره مرره مرره مرره مرره
+
+146
+00:11:55,110 --> 00:11:56,550
+مرره مرره مرره مرره مرره مرره مرره مرره مرره مرره
+
+147
+00:11:56,550 --> 00:11:59,490
+مرره مرره مرره مرره مرره مرره مرره مرره مرره مرره
+
+148
+00:11:59,490 --> 00:12:04,370
+مرره مرره
+
+149
+00:12:04,370 --> 00:12:10,470
+مرر
+
+150
+00:12:13,660 --> 00:12:19,220
+Okay thank you very much I have met many people I
+
+151
+00:12:19,220 --> 00:12:23,260
+have met I have met you came to the university
+
+152
+00:12:23,260 --> 00:12:28,780
+have you met new friends new people okay what
+
+153
+00:12:28,780 --> 00:12:35,200
+about the actionrepeated and still going on still
+
+154
+00:12:35,200 --> 00:12:39,140
+going on you are expected to meet what more people
+
+155
+00:12:39,140 --> 00:12:44,420
+okay so the present perfect can also be used yes
+
+156
+00:12:44,420 --> 00:12:55,380
+دعا قريد repeatedly
+
+157
+00:12:55,380 --> 00:12:57,860
+repeatedly repeated yeah
+
+158
+00:13:02,070 --> 00:13:07,550
+thank you good from a point in time look this term
+
+159
+00:13:07,550 --> 00:13:11,490
+so far this term we started this term in september
+
+160
+00:13:11,490 --> 00:13:15,830
+i have given you 10 lectures for example i have
+
+161
+00:13:15,830 --> 00:13:20,050
+given repeated action came here when did you come
+
+162
+00:13:20,050 --> 00:13:27,170
+here in september again now how
+
+163
+00:13:27,170 --> 00:13:32,920
+do we use the present perfect tenseكيف نستخدمها؟
+
+164
+00:13:32,920 --> 00:13:41,080
+في الأمثلة السابقة، هل قد كنت محرك؟ لقد عشت، لقد
+
+165
+00:13:41,080 --> 00:13:47,220
+علمت، هل الفعل مرتبط
+
+166
+00:13:47,220 --> 00:13:52,100
+فقط مع الماضي، فقط مع الحال؟ أو ماذا؟ هل يمكنك أن
+
+167
+00:13:52,100 --> 00:13:56,960
+تشرح؟ ما هي علاقة بين الوقت و الفعل؟ يا جهان، هل
+
+168
+00:13:56,960 --> 00:14:02,090
+تريد أن تقول شيء؟we use present perfect when we
+
+169
+00:14:02,090 --> 00:14:10,290
+talk about the action there is a connection okay
+
+170
+00:14:10,290 --> 00:14:17,750
+go on there is a connection between okay thank you
+
+171
+00:14:17,750 --> 00:14:23,930
+it started it started in the pastI have joined the
+
+172
+00:14:23,930 --> 00:14:28,130
+university. This started in the past. Are you
+
+173
+00:14:28,130 --> 00:14:33,150
+still joining? So there is a connection with the
+
+174
+00:14:33,150 --> 00:14:36,550
+past and the present. There is a connection. This
+
+175
+00:14:36,550 --> 00:14:40,470
+is in generalنستخدمها عندما يكون هناك علاقة مع
+
+176
+00:14:40,470 --> 00:14:46,090
+الماضي والماضي وكما تعلمين نستخدمها لإدعاء ماذا؟
+
+177
+00:14:46,090 --> 00:14:51,650
+تجربة، لإظهار تجربة، أيضًا تغيير ومواصلة الحالة
+
+178
+00:14:51,650 --> 00:15:02,750
+دعونا نلقي نظرة عندما .. عندما .. عندما أقول على
+
+179
+00:15:02,750 --> 00:15:10,410
+سبيل المثال لقد رأيت والديأنا قد رأيت أبك، أنا
+
+180
+00:15:10,410 --> 00:15:20,130
+أتكلم عن ماذا؟ تجربة في الماضي، أنا قد زرت كايرو،
+
+181
+00:15:20,130 --> 00:15:25,250
+تجربة في الماضي، كان يعيش في كايرو، هل كنت أبقى
+
+182
+00:15:25,250 --> 00:15:35,040
+هناك أبقى؟ لا، نعم، فنحن نتكلم عن ماذا؟هل نحن
+
+183
+00:15:35,040 --> 00:15:40,380
+مهتمين بالوقت عندما حدث التجارب؟ لسنا مهتمين
+
+184
+00:15:40,380 --> 00:15:47,460
+بالوقت هل رأيت ليون؟ هل زرت دبي؟ هل كنت في رفح؟
+
+185
+00:15:47,460 --> 00:15:54,060
+انا اتكلم عن تجارب ماضية تجارب ماضية تجارب ماضية
+
+186
+00:15:54,060 --> 00:15:54,600
+تجارب ماضية تجارب ماضية تجارب ماضية تجارب ماضية
+
+187
+00:15:54,600 --> 00:15:54,740
+تجارب ماضية تجارب ماضية تجارب ماضية تجارب ماضية
+
+188
+00:15:54,740 --> 00:15:55,400
+تجارب ماضية تجارب ماضية تجارب ماضية تجارب ماضية
+
+189
+00:15:55,400 --> 00:15:55,620
+تجارب ماضية تجارب ماضية تجارب ماضية تجارب ماضية
+
+190
+00:15:55,620 --> 00:16:02,220
+تجارب ماضية تجارب ماضية تجارب ماضية تجارب ماضوانت
+
+191
+00:16:02,220 --> 00:16:06,660
+تتعرف على حالتك السابقة او حالتك السابقة وانت قد
+
+192
+00:16:06,660 --> 00:16:09,260
+رأيت هذا حدث في السابقة وانت قد رأيت هذا حدث في
+
+193
+00:16:09,260 --> 00:16:10,520
+السابقة وانت قد رأيت هذا حدث في السابقة وانت قد
+
+194
+00:16:10,520 --> 00:16:12,020
+رأيت هذا حدث في السابقة وانت قد رأيت هذا حدث في
+
+195
+00:16:12,020 --> 00:16:13,680
+السابقة وانت قد رأيت هذا حدث في السابقة وانت قد
+
+196
+00:16:13,680 --> 00:16:13,680
+رأيت هذا حدث في السابقة وانت قد رأيت هذا حدث في
+
+197
+00:16:13,680 --> 00:16:13,680
+السابقة وانت قد رأيت هذا حدث في السابقة وانت قد
+
+198
+00:16:13,680 --> 00:16:14,800
+رأيت هذا حدث في السابقة وانت قد رأيت هذا حدث في
+
+199
+00:16:14,800 --> 00:16:19,820
+السابقة وانت قد رأيت هذا حدث في السابقةإذا رأيته
+
+200
+00:16:19,820 --> 00:16:25,800
+سأعرفه، سأعرف أن هو أبكارك، ما هي الاتصال بين
+
+201
+00:16:25,800 --> 00:16:32,300
+الماضي و الماضي؟ الأحداث كانت في الماضي و مازلت في
+
+202
+00:16:32,300 --> 00:16:37,760
+رأسي، لدي تذكرة عن الأحداث، أعرف شيء عن الأحداث،
+
+203
+00:16:37,760 --> 00:16:44,860
+هذه التذكرة هي ماذا؟ تجربة، هل يمكنك أن تعطيني مثل
+
+204
+00:16:44,860 --> 00:16:45,740
+هذا؟
+
+205
+00:16:48,870 --> 00:16:55,270
+Talk about yourself I
+
+206
+00:16:55,270 --> 00:17:02,630
+have visited Dubai I have met the prime minister I
+
+207
+00:17:02,630 --> 00:17:11,290
+have eaten my cake thank you I have seen the
+
+208
+00:17:11,290 --> 00:17:15,510
+pyramids thank you very much very good thank you
+
+209
+00:17:15,510 --> 00:17:19,810
+very muchالان ايضا نستخدم الـ present perfect
+
+210
+00:17:19,810 --> 00:17:26,170
+tense لتغييره to express what change when you say
+
+211
+00:17:26,170 --> 00:17:31,870
+I have bought a car I have bought a car look last
+
+212
+00:17:31,870 --> 00:17:37,510
+week I did not have a car but this week now I have
+
+213
+00:17:37,510 --> 00:17:45,600
+Ali has broken his legفي الماضي كان لديه لقه جيد،
+
+214
+00:17:45,600 --> 00:17:54,820
+اليوم لديه لقه سيء، لقه محطم، هل سعره ارتفع؟ يوم
+
+215
+00:17:54,820 --> 00:18:01,500
+السابق سعره كان شيء و اليوم هو شيء آخرالشرطة قامت
+
+216
+00:18:01,500 --> 00:18:07,380
+بتجريب المقتل يوم السابق المقتل كان حر قامت بتجريب
+
+217
+00:18:07,380 --> 00:18:13,360
+المقتل كان حر و الأن هو في مجلس مجلس مجلس مجلس
+
+218
+00:18:13,360 --> 00:18:14,540
+مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس
+
+219
+00:18:14,540 --> 00:18:16,620
+مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس
+
+220
+00:18:16,620 --> 00:18:16,940
+مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس
+
+221
+00:18:16,940 --> 00:18:16,960
+مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس مجلس
+
+222
+00:18:16,960 --> 00:18:26,520
+مجلس م
+
+223
+00:18:28,820 --> 00:18:37,920
+نحن نتكلم عن هذا قليل من الوقت قبل ان انا اتكلم عن
+
+224
+00:18:37,920 --> 00:18:40,260
+نفسي انا اتكلم عن نفسي انا اتكلم عن نفسي انا اتكلم
+
+225
+00:18:40,260 --> 00:18:40,500
+عن نفسي انا اتكلم عن نفسي انا اتكلم عن نفسي انا
+
+226
+00:18:40,500 --> 00:18:40,840
+اتكلم عن نفسي انا اتكلم عن نفسي انا اتكلم عن نفسي
+
+227
+00:18:40,840 --> 00:18:42,940
+انا اتكلم عن نفسي انا اتكلم عن نفسي انا اتكلم عن
+
+228
+00:18:42,940 --> 00:18:43,300
+نفسي انا اتكلم عن نفسي انا اتكلم عن نفسي انا اتكلم
+
+229
+00:18:43,300 --> 00:18:43,760
+عن نفسي انا اتكلم عن نفسي انا اتكلم عن نفسي انا
+
+230
+00:18:43,760 --> 00:18:47,120
+اتكلم عن نفسي انا اتكلم عن نفسي انا اتكلم عن نفسي
+
+231
+00:18:47,120 --> 00:18:49,820
+انا اتك
+
+232
+00:18:50,660 --> 00:18:56,760
+تحدث عن حالة تستمر، عندما أسألك أين فاطمة؟ لقد
+
+233
+00:18:56,760 --> 00:19:02,520
+كانت مريضة لعامين، لقد كانت مريضة، بدأت في الماضي
+
+234
+00:19:02,520 --> 00:19:08,900
+و ما زلت كذلك، كم وقت كنت تعرفت على علا؟ بدأت في
+
+235
+00:19:08,900 --> 00:19:15,500
+الماضي و ما زلت كذلك، والحالة الماضيةبدأت في الوضع
+
+236
+00:19:15,500 --> 00:19:22,440
+وبدأت في الماضي وفي جميع الاسماء مازالت تستمر حتى
+
+237
+00:19:22,440 --> 00:19:28,240
+الآن ماذا سيحصل؟ ماذا عن المستقبل؟ ربما سيكون
+
+238
+00:19:28,240 --> 00:19:34,200
+متوقع ان تستمر متوقع ان تستمر عندما تقول على سبيل
+
+239
+00:19:34,200 --> 00:19:40,080
+المثال انها كانت مريضة ل2 أيام لا نعرف عندما ستصل
+
+240
+00:19:40,080 --> 00:19:41,140
+إلى المدرسة
+
+241
+00:19:44,940 --> 00:19:50,840
+قبل أن نتحرك، أود أن تقسم هذه النقطة مرة أخرى، من
+
+242
+00:19:50,840 --> 00:19:52,000
+يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر
+
+243
+00:19:52,000 --> 00:19:55,700
+يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر
+
+244
+00:19:55,700 --> 00:19:56,620
+يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر
+
+245
+00:19:56,620 --> 00:20:00,260
+يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر
+
+246
+00:20:00,260 --> 00:20:00,380
+يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر
+
+247
+00:20:00,380 --> 00:20:00,380
+يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر يقدر
+
+248
+00:20:00,380 --> 00:20:13,240
+يقدر يقدر يقدر يقدر يقدر يقدر ي
+
+249
+00:20:15,000 --> 00:20:19,820
+still going on until now also the present perfect
+
+250
+00:20:19,820 --> 00:20:23,720
+is used when we see things happening in the past
+
+251
+00:20:23,720 --> 00:20:28,980
+but having a result in the present things
+
+252
+00:20:28,980 --> 00:20:35,720
+happening in the past but having a result in the
+
+253
+00:20:35,720 --> 00:20:40,730
+presentwould you like to have breakfast with me if
+
+254
+00:20:40,730 --> 00:20:44,550
+a friend now invites you to breakfast and you had
+
+255
+00:20:44,550 --> 00:20:48,370
+breakfast at home what do you say i ate breakfast
+
+256
+00:20:48,370 --> 00:20:54,490
+or i had eaten my breakfast what do you say yeah i
+
+257
+00:20:54,490 --> 00:20:57,950
+have eaten my breakfast thank you very much i have
+
+258
+00:20:57,950 --> 00:21:04,370
+eaten my breakfast yeahهل قد أكلت؟ يمكنك أن تقول
+
+259
+00:21:04,370 --> 00:21:08,430
+انا قد أكلت، يمكنك أن تقول انا قد أكلت، يمكنك أن
+
+260
+00:21:08,430 --> 00:21:12,830
+تقول انا قد أكلت صباحي، لكن هذا يتعامل مع الرسالة
+
+261
+00:21:12,830 --> 00:21:16,150
+التي تريد أن ترسلها إلى الشخص الاخر. مرة أخرى، أنا
+
+262
+00:21:16,150 --> 00:21:22,090
+أسألك، إنها تقبلك إلى الصباح. لديك صباح في المنزل
+
+263
+00:21:22,090 --> 00:21:23,630
+و لا تشعرين
+
+264
+00:21:29,260 --> 00:21:37,180
+هل انا اكل في الصباح او انا اكل في الصباح؟ انا اكل
+
+265
+00:21:37,180 --> 00:21:41,520
+في الصباح، شكرا، انا اكل في الصباح. حسنا؟ الآن،
+
+266
+00:21:41,520 --> 00:21:46,320
+انظر إلى الغرفة التي تجلس فيها، هل هي صافية؟ نعم،
+
+267
+00:21:46,320 --> 00:21:47,940
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+268
+00:21:47,940 --> 00:21:48,320
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+269
+00:21:48,320 --> 00:21:49,440
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+270
+00:21:49,440 --> 00:21:51,920
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+271
+00:21:51,920 --> 00:21:56,740
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نvery
+
+272
+00:21:56,740 --> 00:21:59,700
+good but why can you tell me why because it's
+
+273
+00:21:59,700 --> 00:22:04,040
+clean now yeah still clean okay having it happened
+
+274
+00:22:04,040 --> 00:22:09,080
+the action happened in the past but still having a
+
+275
+00:22:09,080 --> 00:22:14,760
+result in the present could you please read we
+
+276
+00:22:14,760 --> 00:22:21,320
+have I want just a minute please read the ed well
+
+277
+00:22:24,480 --> 00:22:29,740
+very good washed we have the dishes now they are
+
+278
+00:22:29,740 --> 00:22:33,340
+clean they are clean thank you yes please read the
+
+279
+00:22:33,340 --> 00:22:37,640
+other one can you okay you cannot see it is small
+
+280
+00:22:37,640 --> 00:22:43,320
+yeah thank you we have eaten all the eggs there
+
+281
+00:22:43,320 --> 00:22:49,840
+aren't left thank you very much yes مروة the plane
+
+282
+00:22:49,840 --> 00:22:55,930
+has landed it is on the groundstill did not leave
+
+283
+00:22:55,930 --> 00:23:02,730
+okay yes please thank
+
+284
+00:23:02,730 --> 00:23:10,550
+you very much good now we can use the present
+
+285
+00:23:10,550 --> 00:23:15,830
+perfect again with what ever and never okay ever
+
+286
+00:23:15,830 --> 00:23:23,490
+and never we use ever any questions
+
+287
+00:23:25,700 --> 00:23:32,160
+Have you ever visited Cairo? Have you ever driven
+
+288
+00:23:32,160 --> 00:23:39,260
+a car? Give me another question Have you
+
+289
+00:23:39,260 --> 00:23:41,900
+ever seen the pyramids? Have you ever driven a
+
+290
+00:23:41,900 --> 00:23:45,660
+horse? Have you ever driven a bus? Thank you very
+
+291
+00:23:45,660 --> 00:23:49,340
+much We ride a horse and we drive okay thank you
+
+292
+00:23:49,340 --> 00:23:54,470
+very much good yeahHave you ever visited America?
+
+293
+00:23:54,690 --> 00:23:58,110
+Thank you very much. Again I'm using it with
+
+294
+00:23:58,110 --> 00:24:03,810
+questionsالأن يمكنك أن تقول لا لقد لم أقضى أبدا
+
+295
+00:24:03,810 --> 00:24:09,290
+لقد لم أقضي أبدا لقد لم أأكل أبدا لقد لم أرا أبدا
+
+296
+00:24:09,290 --> 00:24:15,370
+لقد لم
+
+297
+00:24:15,370 --> 00:24:19,290
+أقضي أبدا لقد لم أقضي أبدا لقد لم أرا أبدا لقد لم
+
+298
+00:24:19,290 --> 00:24:19,430
+أقضي أبدا لقد لم أرا أبدا لقد لم أقضي أبدا لقد لم
+
+299
+00:24:19,430 --> 00:24:21,430
+أقضي أبدا لأبدا لأبدا لأبدا لأبدا لأبدا لأبدا
+
+300
+00:24:21,430 --> 00:24:25,210
+لأبدا لأبدا لأبدا لأبدا لأبدا لأبدا لأبدا لأبدا
+
+301
+00:24:25,210 --> 00:24:25,510
+لأبدا لأبدا لأبدا لأبدا لأبدا لأبدا لأبدا لأبدا
+
+302
+00:24:25,510 --> 00:24:30,830
+لأبدا لأبدا لأبدا لأبدا لأبدا لأبدامن يقدر يقرأ
+
+303
+00:24:30,830 --> 00:24:36,250
+هذا المثال؟ هل قدرت أن تحب الانسان الصغير؟ شكرا،
+
+304
+00:24:36,250 --> 00:24:42,710
+التالت بفضل انا لم اقرأ اي موتور بيك في حياتي شكرا
+
+305
+00:24:42,710 --> 00:24:49,230
+جدا ريدن ما هو الانفينيطيف؟ رايت، جيد جدا، بفضل
+
+306
+00:24:49,230 --> 00:24:54,510
+انا لم اقرأ اي موتور بيك في حياتي شكرا جدا، و
+
+307
+00:24:54,510 --> 00:24:59,970
+أخيرا هذا الموضوع أعظم مستخدم يمكنك أن تحصل عليهwe
+
+308
+00:24:59,970 --> 00:25:04,970
+have ever stayed in thank you very much now also
+
+309
+00:25:04,970 --> 00:25:10,710
+just and the immediate past where is the teacher
+
+310
+00:25:10,710 --> 00:25:16,950
+he has just leftWhere is the plane it has just
+
+311
+00:25:16,950 --> 00:25:21,170
+departed it has just departed what do you
+
+312
+00:25:21,170 --> 00:25:25,510
+understand now would you like to eat with me to
+
+313
+00:25:25,510 --> 00:25:29,030
+have breakfast with me thank you i have just eaten
+
+314
+00:25:29,030 --> 00:25:33,450
+i have just eaten what do you understand from the
+
+315
+00:25:33,450 --> 00:25:38,870
+word just yeah it is yeah yeah in the immediate
+
+316
+00:25:38,870 --> 00:25:44,790
+past in the immediate past stillI have just done
+
+317
+00:25:44,790 --> 00:25:50,550
+something so in that the action was completed when
+
+318
+00:25:50,550 --> 00:25:55,970
+I say the teacher has left the bus has arrived the
+
+319
+00:25:55,970 --> 00:26:00,250
+action is completed okay and when in the immediate
+
+320
+00:26:00,250 --> 00:26:04,770
+past just minutes before now read this example
+
+321
+00:26:04,770 --> 00:26:11,030
+please he he has just left okay thank you next one
+
+322
+00:26:11,030 --> 00:26:20,370
+pleaseشكرا جميل لقد فتح الوقت الى عشر الآن اقرأ
+
+323
+00:26:20,370 --> 00:26:30,210
+مرة أخرى هذا نقطة أخرى شكرا إذا أسألك إذا أقول لك
+
+324
+00:26:30,210 --> 00:26:38,330
+لقد خسرت مفاتيحي أين مفاتيحي؟ لقد خسرتهم لقد خسرت
+
+325
+00:26:38,330 --> 00:26:38,830
+مفاتيحي
+
+326
+00:26:42,290 --> 00:26:47,990
+I have finished my homework. Did we mention the
+
+327
+00:26:47,990 --> 00:26:52,690
+time? No. Now which is more important, the action
+
+328
+00:26:52,690 --> 00:26:59,570
+or the result? The action. I have lost my pen. It
+
+329
+00:26:59,570 --> 00:27:03,090
+is not important when, but the action is still. I
+
+330
+00:27:03,090 --> 00:27:09,240
+have a problem now. I cannot write.عندما تقول انا
+
+331
+00:27:09,240 --> 00:27:12,880
+قد قطعت يدي،
+
+332
+00:27:12,880 --> 00:27:19,340
+هل هذا مهم؟ عندما تقول انا
+
+333
+00:27:19,340 --> 00:27:28,980
+قد قطعت يدي، هل هذا مهم؟ عندما تقول انا
+
+334
+00:27:28,980 --> 00:27:32,060
+قد قطعت يدي، هل هذا مهم؟ عندما تقول انا قد قطعت
+
+335
+00:27:32,060 --> 00:27:35,350
+يدي، هل هذا مهم؟النتيجة مهمة أكتر من الحركة،
+
+336
+00:27:35,350 --> 00:27:40,850
+النتيجة، ما هي النتيجة للقطع؟ انا قطعت يدي،
+
+337
+00:27:40,850 --> 00:27:48,270
+النتيجة هي أنها تبتد، تبتد، فهذه هي النتيجة، لقد
+
+338
+00:27:48,270 --> 00:27:53,970
+انتهيت من عملي، لقد انتهيت من عملي، ما هي النتيجة؟
+
+339
+00:27:54,770 --> 00:27:58,910
+I'm free now. The result is I'm free now. I can do
+
+340
+00:27:58,910 --> 00:28:03,170
+whatever I want. So we use the present perfect
+
+341
+00:28:03,170 --> 00:28:08,830
+when the result when the effect is more important
+
+342
+00:28:08,830 --> 00:28:17,590
+than the action itself Contractions
+
+343
+00:28:18,750 --> 00:28:23,290
+in writing how do we write the present perfect
+
+344
+00:28:23,290 --> 00:28:27,630
+contraction means the short form a short form
+
+345
+00:28:27,630 --> 00:28:32,090
+usually you say I have been you have been we have
+
+346
+00:28:32,090 --> 00:28:37,820
+okay they have been he's beenhe's okay and so on
+
+347
+00:28:37,820 --> 00:28:41,200
+have and has usually contracted with the personal
+
+348
+00:28:41,200 --> 00:28:45,420
+pronouns as you see he's there what does it mean
+
+349
+00:28:45,420 --> 00:28:50,840
+he's there he is there he's been he has he's he
+
+350
+00:28:50,840 --> 00:28:55,960
+has how can we differentiate by this s and this s
+
+351
+00:28:55,960 --> 00:29:01,840
+how can we know now he's playing he's playing and
+
+352
+00:29:01,840 --> 00:29:02,860
+he's played
+
+353
+00:29:15,600 --> 00:29:20,780
+it is progressive or for example another word not
+
+354
+00:29:20,780 --> 00:29:23,480
+the past participle thank you could you please
+
+355
+00:29:23,480 --> 00:29:27,560
+look at your book and do the exercise I'll give
+
+356
+00:29:27,560 --> 00:29:31,900
+you five
+
+357
+00:29:31,900 --> 00:29:38,360
+minutes five minutes only to do1 2 3 4 5 او فقط
+
+358
+00:29:38,360 --> 00:29:40,700
+لحظة بيتر فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط
+
+359
+00:29:40,700 --> 00:29:44,300
+فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط
+
+360
+00:29:44,300 --> 00:29:45,060
+فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط
+
+361
+00:29:45,060 --> 00:29:55,920
+فقط
+
+362
+00:29:55,920 --> 00:29:57,720
+فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط
+
+363
+00:29:57,720 --> 00:29:59,600
+فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط
+
+364
+00:29:59,600 --> 00:29:59,600
+فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط
+
+365
+00:29:59,600 --> 00:30:01,620
+فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط
+
+366
+00:30:01,620 --> 00:30:01,620
+فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط
+
+367
+00:30:01,620 --> 00:30:06,570
+فقط فقط فقط فقط فقط فقط فقط فقط فقطGo on how did
+
+368
+00:30:06,570 --> 00:30:13,210
+you answer your questions yes okay that's nice
+
+369
+00:30:13,210 --> 00:30:16,870
+that's nice anyhow complete the exercise at home
+
+370
+00:30:16,870 --> 00:30:24,230
+and check the answers now what about have and has
+
+371
+00:30:24,230 --> 00:30:29,370
+in spoken English in spoken English usually
+
+372
+00:30:31,370 --> 00:30:34,630
+عندما يتحدث الناس يريدون أن يكونوا ماذا؟ بسرعة
+
+373
+00:30:34,630 --> 00:30:43,190
+يريدون أن يكونوا بسرعة وكذلك لدرجة ما الناس تتحدث
+
+374
+00:30:43,190 --> 00:30:49,970
+معاها بطريقة غير عادية بطريقة غير عادية كأنك تتحدث
+
+375
+00:30:49,970 --> 00:30:57,950
+مع صديقك لكن في الكتابة الكتابة أكثر عادية أكثر
+
+376
+00:30:57,950 --> 00:31:05,150
+عاديةعندما نتحدث عندما الناس يتحدث عادة يريدون أن
+
+377
+00:31:05,150 --> 00:31:12,970
+يكونوا سريعين بدلا من أن يقولوا كيف كنتم؟ كيف
+
+378
+00:31:12,970 --> 00:31:16,410
+كنتم؟ كيف كنتم؟ كيف كنتم؟ كيف كنتم؟ كيف كنتم؟ كيف
+
+379
+00:31:16,410 --> 00:31:17,710
+كنتم؟ كيف كنتم؟ كيف كنتم؟ كيف كنتم؟ كيف كنتم؟ كيف
+
+380
+00:31:17,710 --> 00:31:19,770
+كنتم؟ كيف كنتم؟ كيف كنتم؟ كيف كنتم؟ كيف كنتم؟ كيف
+
+381
+00:31:19,770 --> 00:31:22,850
+كنتم؟ كيف كنتم؟ كيف كنتم؟ كيف كنتم؟ كيف كنتم؟ كيف
+
+382
+00:31:22,850 --> 00:31:27,730
+كنتم؟ كيف كنتم؟ كيف كنتم؟ كيف كنتم؟ كيف كنتم؟ كيف
+
+383
+00:31:27,730 --> 00:31:29,610
+كنتم؟ كيف كنتم؟ كيف كنتم؟ كيف كنتم؟ كيف كنتم؟yes
+
+384
+00:31:29,610 --> 00:31:35,110
+thank you very much yeah thank you now jane has
+
+385
+00:31:35,110 --> 00:31:41,430
+already eaten lunch in spain we say yeah thank you
+
+386
+00:31:41,430 --> 00:31:50,870
+james look james james okay again yeah thank you
+
+387
+00:31:50,870 --> 00:31:57,890
+mike has already left uh yeah thank you and yeah
+
+388
+00:31:59,180 --> 00:32:02,760
+Thank you very much. So again in spoken English,
+
+389
+00:32:03,120 --> 00:32:05,620
+the present perfect helping verbs, they are
+
+390
+00:32:05,620 --> 00:32:10,620
+contracted. Okay, they are reduced as we saw in
+
+391
+00:32:10,620 --> 00:32:18,280
+these examples. Note in very informal writing, has
+
+392
+00:32:18,280 --> 00:32:22,720
+is sometimes contracted with nouns. Has also.
+
+393
+00:32:23,680 --> 00:32:30,410
+Okay, I say what?james already eaten look already
+
+394
+00:32:30,410 --> 00:32:35,910
+this is has why it is perfect and the question
+
+395
+00:32:35,910 --> 00:32:41,530
+words for example we can this is we use it with
+
+396
+00:32:41,530 --> 00:32:45,010
+nouns we can reduce it with nouns and with
+
+397
+00:32:45,010 --> 00:32:50,170
+question words okay have is rarely contracted in
+
+398
+00:32:50,170 --> 00:32:56,150
+writingin writing usually they write it but in
+
+399
+00:32:56,150 --> 00:33:01,080
+speech they do except with pronounsexcept with
+
+400
+00:33:01,080 --> 00:33:08,220
+pronouns you cannot say for example you cannot if
+
+401
+00:33:08,220 --> 00:33:10,220
+you want to mention the noun if you want to
+
+402
+00:33:10,220 --> 00:33:14,780
+mention the word okay don't reduce have but you
+
+403
+00:33:14,780 --> 00:33:17,520
+can reduce it with the pronouns you can say I have
+
+404
+00:33:17,520 --> 00:33:22,060
+okay you have and so on you can write the reduced
+
+405
+00:33:22,060 --> 00:33:28,100
+way now present perfect and simple present perfect
+
+406
+00:33:28,100 --> 00:33:29,140
+and simple past
+
+407
+00:33:31,970 --> 00:33:34,350
+هل يمكنك أن تخبرني .. هل يمكنك أن تتذكر .. لقد
+
+408
+00:33:34,350 --> 00:33:37,210
+تحدثنا قبل عن الفرق .. الفرق الرئيسي بين الـ
+
+409
+00:33:37,210 --> 00:33:40,910
+Present Perfect والقاعدة الماضية .. اسمع .. لقد
+
+410
+00:33:40,910 --> 00:33:43,550
+قالنا أن الـ Present Perfect مستخدم للتحدث عن
+
+411
+00:33:43,550 --> 00:33:47,470
+حالتها التي حدثت في القاعدة الماضية .. حسنًا؟
+
+412
+00:33:47,470 --> 00:33:54,270
+ومازال .. سمبل القاعدة الماضية مستخدم للتحدث عن ..
+
+413
+00:33:55,840 --> 00:33:58,600
+completely finished actions in the past thank you
+
+414
+00:33:58,600 --> 00:34:02,020
+very much what's the main difference between the
+
+415
+00:34:02,020 --> 00:34:08,040
+two tenses yeah very
+
+416
+00:34:08,040 --> 00:34:16,260
+good thank you very much so againفي الماضي البسيط
+
+417
+00:34:16,260 --> 00:34:23,240
+نتكلم عن افعال التي حدثت في وقت محدد في الماضي وقت
+
+418
+00:34:23,240 --> 00:34:29,120
+محدد في الماضي ولكن في الوقت المناسب نحن لا نحدث
+
+419
+00:34:29,120 --> 00:34:36,460
+عن وقت محدد الأن قرأ .. من يريد أن يقرأ؟ أنا قابلة
+
+420
+00:34:36,460 --> 00:34:40,480
+ليندا ولكن لم أقابل زوجها
+
+421
+00:34:43,080 --> 00:34:49,820
+Okay thank you yeah read please again the present
+
+422
+00:34:49,820 --> 00:34:55,240
+perfect is used specific
+
+423
+00:34:55,240 --> 00:35:01,620
+time thank you no specific time have you i have
+
+424
+00:35:01,620 --> 00:35:08,360
+met i have met okay i haven't met have you met are
+
+425
+00:35:08,360 --> 00:35:14,110
+we talking about a specific time noOkay now just
+
+426
+00:35:14,110 --> 00:35:17,850
+we are talking about actions that happened what
+
+427
+00:35:17,850 --> 00:35:22,690
+before now happened before in the past look at the
+
+428
+00:35:22,690 --> 00:35:26,050
+example the other example yeah who wants to read
+
+429
+00:35:26,050 --> 00:35:34,170
+yeah look I met yesterday I met yesterday okay go
+
+430
+00:35:34,170 --> 00:35:37,650
+on her
+
+431
+00:35:37,650 --> 00:35:42,700
+husband was there was didn't meetwas there too but
+
+432
+00:35:42,700 --> 00:35:45,880
+I didn't meet him did you meet them at the bar
+
+433
+00:35:45,880 --> 00:35:49,520
+thank you very much all the actions happened when
+
+434
+00:35:49,520 --> 00:35:54,380
+okay in the which past yesterday yesterday
+
+435
+00:35:54,380 --> 00:35:59,360
+expresses what a specific time in the past
+
+436
+00:35:59,360 --> 00:36:03,600
+expresses a specific time in the past now the
+
+437
+00:36:03,600 --> 00:36:07,820
+simple past expresses a specific time in the past
+
+438
+00:36:07,820 --> 00:36:16,220
+but the present perfectOkay that's right look
+
+439
+00:36:16,220 --> 00:36:21,980
+again can you read the example please Sammy yeah
+
+440
+00:36:21,980 --> 00:36:31,420
+for 10 years okay has
+
+441
+00:36:31,420 --> 00:36:36,060
+been a teacher for 10 years he loves teaching he
+
+442
+00:36:36,060 --> 00:36:41,740
+loves teachingهل هو مازال يتعلم؟ نعم، نعم، نعم،
+
+443
+00:36:41,740 --> 00:36:41,740
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+444
+00:36:41,740 --> 00:36:43,420
+نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم،
+
+445
+00:36:43,420 --> 00:36:52,160
+نعم، نعم، نعم، نعم، نعم، نعمyes, completely
+
+446
+00:36:52,160 --> 00:36:55,320
+finished action in the past now the present
+
+447
+00:36:55,320 --> 00:36:58,220
+perfect is used for situations that began in the
+
+448
+00:36:58,220 --> 00:37:02,160
+past and continue the present okay tells that
+
+449
+00:37:02,160 --> 00:37:07,460
+Sammy if you say I have been okay Sammy has been I
+
+450
+00:37:07,460 --> 00:37:11,560
+have taught I have been a teacher the action
+
+451
+00:37:11,560 --> 00:37:16,920
+started in the past and still going on now look at
+
+452
+00:37:16,920 --> 00:37:18,860
+the other examples yeah please read
+
+453
+00:37:21,610 --> 00:37:26,510
+from nineteen ninety four to two thousand and five
+
+454
+00:37:26,510 --> 00:37:32,670
+and now he is a a salesman is he still teaching no
+
+455
+00:37:32,670 --> 00:37:38,250
+so علي was a teacher a completed action in the
+
+456
+00:37:38,250 --> 00:37:44,910
+past has been a teacher still going on still
+
+457
+00:37:44,910 --> 00:37:49,050
+teaching still teaching so read again please the
+
+458
+00:37:49,050 --> 00:37:50,450
+simple past is used
+
+459
+00:38:03,180 --> 00:38:08,620
+very good علي is not a teacher now علي is not a
+
+460
+00:38:08,620 --> 00:38:12,900
+teacher now yeah you of course
+
+461
+00:38:22,270 --> 00:38:25,750
+just to show the period you refer to a special to
+
+462
+00:38:25,750 --> 00:38:32,730
+a certain point in time we said far and sinceوهو
+
+463
+00:38:32,730 --> 00:38:47,670
+يظهر ويظهر ويظهر ويظهر ويظهر ويظهر ويظهر ويظهر
+
+464
+00:38:47,670 --> 00:38:50,390
+ويظهر
+
+465
+00:38:53,170 --> 00:38:57,090
+بعد ذلك نستطيع أن ندرس هذه الوقت المحدد في الماضي
+
+466
+00:38:57,090 --> 00:39:01,490
+بطرق مختلفة واحدة من الطرق هي عندما نستطيع أن
+
+467
+00:39:01,490 --> 00:39:08,400
+نستخدم forأذا كما لو كانت تسأل هل for استخدم فقط
+
+468
+00:39:08,400 --> 00:39:12,260
+مع الـ present perfect؟ لا يمكننا استخدامه لتوصيل
+
+469
+00:39:12,260 --> 00:39:17,040
+الرسالة نريد أن نقول للقراء أو لالكتاب أريد أن
+
+470
+00:39:17,040 --> 00:39:21,960
+أعرف وقت محدد في الماضي، لذلك يمكنك استخدام أي
+
+471
+00:39:21,960 --> 00:39:28,120
+كلمة لذلك أشياء أخرى؟
+
+472
+00:39:31,850 --> 00:39:40,010
+هل يمكنك أن تغلق الجزء؟ افتح
+
+473
+00:39:40,010 --> 00:39:46,850
+عقلكم ماذا قلنا اليوم؟ ماذا تحدثنا عنه اليوم؟ افتح
+
+474
+00:39:46,850 --> 00:39:48,330
+عقلكم ماذا قلنا اليوم؟ ماذا تحدثنا اليوم؟ افتح
+
+475
+00:39:48,330 --> 00:39:50,170
+عقلكم ماذا تحدثنا اليوم؟ ماذا تحدثنا اليوم؟ افتح
+
+476
+00:39:50,170 --> 00:39:50,630
+عقلكم ماذا تحدثنا اليوم؟ ماذا تحدثنا اليوم؟ ماذا
+
+477
+00:39:50,630 --> 00:39:50,630
+تحدثنا اليوم؟ ماذا تحدثنا اليوم؟ ماذا تحدثنا
+
+478
+00:39:50,630 --> 00:39:50,630
+اليوم؟ ماذا تحدثنا اليوم؟ ماذا تحدثنا اليوم؟ ماذا
+
+479
+00:39:50,630 --> 00:39:50,990
+تحدثنا اليوم؟ ماذا تحدثنا اليوم؟ ماذا تحدثنا
+
+480
+00:39:50,990 --> 00:39:57,390
+اليوم؟ ماذا تحدثنا اليوم؟ ماذا
+
+481
+00:39:57,390 --> 00:39:57,390
+تحدثنا الي
+
+482
+00:40:02,290 --> 00:40:05,150
+Okay, past simple and present perfect. What did we
+
+483
+00:40:05,150 --> 00:40:06,050
+say about that?
+
+484
+00:40:11,510 --> 00:40:15,190
+Okay, happened and completed in the past. Yeah.
+
+485
+00:40:15,870 --> 00:40:16,810
+And the perfect?
+
+486
+00:40:19,830 --> 00:40:24,130
+Started in the past up to now and may continue.
+
+487
+00:40:24,290 --> 00:40:27,110
+Thank you very much. Good. Yes, there. Can you say
+
+488
+00:40:27,110 --> 00:40:29,830
+something? Who wants to say something? Yeah.
+
+489
+00:40:36,790 --> 00:40:40,430
+very good the effect is more important thank you
+
+490
+00:40:40,430 --> 00:40:44,510
+what's
+
+491
+00:40:44,510 --> 00:40:49,390
+the difference okay
+
+492
+00:40:49,390 --> 00:40:53,330
+point
+
+493
+00:40:53,330 --> 00:40:56,210
+in time can you give me examples with time
+
+494
+00:40:56,210 --> 00:41:00,210
+expressions used with for and since yeah
+
+495
+00:41:02,110 --> 00:41:06,050
+since since only since since what since March
+
+496
+00:41:06,050 --> 00:41:15,310
+since thank you good for yeah four years three
+
+497
+00:41:15,310 --> 00:41:19,230
+years good yeah tell me other points yes please
+
+498
+00:41:19,230 --> 00:41:24,110
+ever used in the question but never used in the
+
+499
+00:41:24,110 --> 00:41:31,230
+answer and ever means never means it's not enough
+
+500
+00:41:31,680 --> 00:41:37,500
+شكرا جزيلا لك قبل أن تستخدم قصة قبل أن تستخدم قصة
+
+501
+00:41:37,500 --> 00:41:38,780
+قبل أن تستخدم قصة قبل أن تستخدم قصة قبل أن تستخدم
+
+502
+00:41:38,780 --> 00:41:41,060
+قصة قبل أن تستخدم قصة قبل أن تستخدم قصة قبل أن
+
+503
+00:41:41,060 --> 00:41:42,660
+تستخدم قصة قبل أن تستخدم قصة قبل أن تستخدم قصة قبل
+
+504
+00:41:42,660 --> 00:41:43,180
+أن تستخدم قصة قبل أن تستخدم قصة قبل أن تستخدم قصة
+
+505
+00:41:43,180 --> 00:41:44,240
+قبل أن تستخدم قصة قبل أن تستخدم قصة قبل أن تستخدم
+
+506
+00:41:44,240 --> 00:41:47,300
+قصة قبل أن تستخدم قصة قبل أن تستخدم قصة قبل أن
+
+507
+00:41:47,300 --> 00:41:51,700
+تستخدم قصة قبل أن تستخدم قصة قبل أن تستخدم قصة قبل
+
+508
+00:41:51,700 --> 00:41:54,630
+أن تستto emphasize the meaning to emphasize the
+
+509
+00:41:54,630 --> 00:41:58,250
+meaning thank you very much good مروة we use just
+
+510
+00:41:58,250 --> 00:42:03,770
+and already as gamers in the present tense to show
+
+511
+00:42:03,770 --> 00:42:08,170
+that the action has happened in the immediate past
+
+512
+00:42:08,170 --> 00:42:10,350
+thank you very much in the immediate past yes
+
+513
+00:42:10,350 --> 00:42:14,090
+please use the present perfect to show experience
+
+514
+00:42:16,260 --> 00:42:20,420
+very good experience change continuing situations
+
+515
+00:42:20,420 --> 00:42:25,940
+thank you سحر okay
+
+516
+00:42:25,940 --> 00:42:32,720
+so in speech we we may reduce them okay good thank
+
+517
+00:42:32,720 --> 00:42:38,660
+you yes please thank
+
+518
+00:42:38,660 --> 00:42:42,900
+you
+
+519
+00:42:42,900 --> 00:42:49,400
+thank you good yeahsimple past in a specific time
+
+520
+00:42:49,400 --> 00:42:52,140
+but we use present perfect when we finish a
+
+521
+00:42:52,140 --> 00:42:54,380
+specific time thank you very much yes please
+
+522
+00:42:54,380 --> 00:43:02,560
+complete
+
+523
+00:43:02,560 --> 00:43:08,360
+it
+
+524
+00:43:08,360 --> 00:43:10,980
+happened and finished or completed thank you very
+
+525
+00:43:10,980 --> 00:43:13,920
+much and finally we use present perfect to ask
+
+526
+00:43:13,920 --> 00:43:17,480
+about actions that happened or notOkay whether
+
+527
+00:43:17,480 --> 00:43:19,920
+they have happened, have you ever visited, have
+
+528
+00:43:19,920 --> 00:43:24,220
+you ever seen, have you ever driven and so on Okay
+
+529
+00:43:24,220 --> 00:43:26,740
+thank you very much, now please do the exercises
+
+530
+00:43:26,740 --> 00:43:29,880
+at home, keep your questions for the next time
+
+531
+00:43:29,880 --> 00:43:36,860
+okay Mark all the difficult points to be discussed
+
+532
+00:43:36,860 --> 00:43:38,820
+in the next lecture, thank you very much
+
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/uMyXfhxFj9o_postprocess.srt b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/uMyXfhxFj9o_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..2b06479f1df20329b74a145d758ea8491a2b0b03
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/uMyXfhxFj9o_postprocess.srt
@@ -0,0 +1,1944 @@
+1
+00:00:21,140 --> 00:00:24,800
+السلام عليكم .. السلام عليكم .. السلام عليكم جميعا
+
+2
+00:00:24,800 --> 00:00:26,880
+.. جميعا .. جميعا .. جميعا .. جميعا .. جميعا ..
+
+3
+00:00:26,880 --> 00:00:34,320
+جميعا .. جميعا .. جميعا
+
+4
+00:00:34,320 --> 00:00:36,020
+.. جميعا .. جميعا .. جميعا .. جميعا .. جميعا ..
+
+5
+00:00:36,020 --> 00:00:36,240
+جميعا .. جميعا .. جميعا .. جميعا .. جميعا .. جميعا
+
+6
+00:00:36,240 --> 00:00:36,260
+.. جميعا .. جميعا .. جميعا .. جميعا .. جميعا ..
+
+7
+00:00:36,260 --> 00:00:38,700
+.. جميعا .. جميعا .. جميعا .. جميعا .. جميعا ..
+
+8
+00:00:38,700 --> 00:00:44,500
+جميعا .. جميعا .. جميعا .. جميعا .. جميعا .. جميعا
+
+9
+00:00:45,910 --> 00:00:53,150
+I have to brush my teeth I have to eat a healthy
+
+10
+00:00:53,150 --> 00:00:56,470
+food thank you I have to tidy up my room good
+
+11
+00:00:56,470 --> 00:01:00,750
+thank you very much now listen all the sentences
+
+12
+00:01:00,750 --> 00:01:05,570
+express what present or future okay they express
+
+13
+00:01:05,570 --> 00:01:09,190
+present or future now if I want to talk about
+
+14
+00:01:09,190 --> 00:01:15,010
+necessityor duties in the past what shall I say I
+
+15
+00:01:15,010 --> 00:01:18,790
+want to talk about what I had to do yesterday yes
+
+16
+00:01:18,790 --> 00:01:26,910
+I had yesterday yesterday I had to study I had to
+
+17
+00:01:26,910 --> 00:01:30,710
+study good thank you yes yesterday I had to visit
+
+18
+00:01:30,710 --> 00:01:33,390
+my grandma I had to visit thank you good yes
+
+19
+00:01:33,390 --> 00:01:39,240
+yesterday I had toI had to clean up my room thank
+
+20
+00:01:39,240 --> 00:01:42,340
+you very much yesterday I had to read Quran good
+
+21
+00:01:42,340 --> 00:01:45,680
+thank you I had to recite the Quran yes please
+
+22
+00:01:45,680 --> 00:01:48,840
+yesterday I had to help my mother thank you very
+
+23
+00:01:48,840 --> 00:01:53,880
+much now when I say I have to I okay have got to I
+
+24
+00:01:53,880 --> 00:01:57,580
+must I must study tonight tonight this expresses
+
+25
+00:01:57,580 --> 00:02:01,500
+what future future so they they are used to
+
+26
+00:02:01,500 --> 00:02:05,880
+express present orNow what about the past if I
+
+27
+00:02:05,880 --> 00:02:09,300
+want to express past necessity or I want to talk
+
+28
+00:02:09,300 --> 00:02:14,540
+about my duties in the past yesterday I had to I
+
+29
+00:02:14,540 --> 00:02:19,500
+had to study I had to go shopping yesterday okay
+
+30
+00:02:19,500 --> 00:02:22,300
+yesterday I had to go shopping there was nothing
+
+31
+00:02:22,300 --> 00:02:27,660
+at home so I went shopping I had to go I had to go
+
+32
+00:02:27,660 --> 00:02:32,080
+shopping look I had to study last night had to is
+
+33
+00:02:32,080 --> 00:02:36,770
+the past form of whatof must and there is no other
+
+34
+00:02:36,770 --> 00:02:40,790
+form when must expresses necessity it is the only
+
+35
+00:02:40,790 --> 00:02:44,830
+form and also it is the past form of what you have
+
+36
+00:02:44,830 --> 00:02:50,310
+to so we say I had to visit I had to clean I had
+
+37
+00:02:50,310 --> 00:02:54,210
+to study and so on to express a necessity in the
+
+38
+00:02:54,210 --> 00:02:57,900
+past now look at this exerciseWould you read the
+
+39
+00:02:57,900 --> 00:03:00,400
+introduction? Show it to me. This is for her. She
+
+40
+00:03:00,400 --> 00:03:03,960
+started. Yeah, we are coming to you later. It's
+
+41
+00:03:03,960 --> 00:03:06,360
+just a suggestion that speaker B might say in
+
+42
+00:03:06,360 --> 00:03:09,160
+response to speaker A. Speaker A, the meeting
+
+43
+00:03:09,160 --> 00:03:12,920
+starts in an hour and we have plenty of time. Just
+
+44
+00:03:12,920 --> 00:03:15,600
+a minute. Just a minute. The meeting starts in an
+
+45
+00:03:15,600 --> 00:03:18,940
+hour. We have plenty of time. Now you start your
+
+46
+00:03:18,940 --> 00:03:21,860
+lectures at eight o'clock. It is seven o'clock
+
+47
+00:03:21,860 --> 00:03:25,420
+now. It is seven o'clock now. Now imagine I'd like
+
+48
+00:03:25,420 --> 00:03:28,990
+you to live the situation.what shall .. somebody
+
+49
+00:03:28,990 --> 00:03:32,770
+says .. calls you your friend .. okay what shall
+
+50
+00:03:32,770 --> 00:03:36,530
+see .. will you say we have .. our lecture starts
+
+51
+00:03:36,530 --> 00:03:39,730
+at eight and it is seven now .. what shall you say
+
+52
+00:03:39,730 --> 00:03:44,230
+.. you don't have to hurry .. okay what about we
+
+53
+00:03:44,230 --> 00:03:49,510
+must not hurry .. you mustn't hurry .. this is
+
+54
+00:03:49,510 --> 00:03:56,060
+must not .. okay what about thatDo you think it is
+
+55
+00:03:56,060 --> 00:03:59,260
+a good expression, a good sentence to say in this
+
+56
+00:03:59,260 --> 00:04:03,960
+situation?No thank you and what about we don't
+
+57
+00:04:03,960 --> 00:04:10,360
+have to hurry, yes or .. or we don't need to hurry
+
+58
+00:04:10,360 --> 00:04:13,880
+thank you very much yes say what you want to say
+
+59
+00:04:13,880 --> 00:04:19,920
+it's not necessary to do very good it is not
+
+60
+00:04:19,920 --> 00:04:23,200
+necessary or it is not very necessary to do now do
+
+61
+00:04:23,200 --> 00:04:27,290
+you thinkwe don't have to means we don't need to
+
+62
+00:04:27,290 --> 00:04:32,150
+.. okay they have almost the same meaning and must
+
+63
+00:04:32,150 --> 00:04:35,170
+is not used here because you know must expresses
+
+64
+00:04:35,170 --> 00:04:42,410
+strong necessity or obligation okay now have to
+
+65
+00:04:42,410 --> 00:04:47,110
+and must in the negative we use them in the
+
+66
+00:04:47,110 --> 00:04:51,830
+positive to express obligation how can we express
+
+67
+00:04:51,830 --> 00:04:59,490
+them inالنقاط الآن مرة أخرى هي الساعة السادسة تبدأ
+
+68
+00:04:59,490 --> 00:05:05,570
+دراستك في الساعة اثنين ماذا تقول؟ انت ترغب ان
+
+69
+00:05:05,570 --> 00:05:11,910
+تغادر بسرعة امك تقول انت لا يجب أن تسرع انت لا يجب
+
+70
+00:05:11,910 --> 00:05:16,130
+أن تسرع هذا هو السبب لا يجب ان تسرع اذا كان هناك
+
+71
+00:05:16,130 --> 00:05:21,650
+الكثير من الوقت يمكنك أن تذهب يمكنك أن تأخذ وقتك
+
+72
+00:05:23,180 --> 00:05:26,440
+carefully to your lecture you don't have to hurry
+
+73
+00:05:26,440 --> 00:05:31,960
+you don't have to hurry again yeah now look
+
+74
+00:05:31,960 --> 00:05:35,080
+tomorrow yes who do you read yes me and you
+
+75
+00:05:35,080 --> 00:05:38,320
+tomorrow is a holiday we don't have to go to class
+
+76
+00:05:38,320 --> 00:05:41,720
+we don't have to go to class it is something
+
+77
+00:05:41,720 --> 00:05:44,940
+normal tomorrow is a holiday you don't have to
+
+78
+00:05:44,940 --> 00:05:48,180
+come to the university it's our weekend tomorrow
+
+79
+00:05:48,180 --> 00:05:51,520
+right so you don't have to come to the university
+
+80
+00:05:52,110 --> 00:05:56,730
+Okay it means you don't need to you don't have to
+
+81
+00:05:56,730 --> 00:06:01,510
+means you don't need to now again another sentence
+
+82
+00:06:01,510 --> 00:06:03,710
+read it please I can tell you you don't have to
+
+83
+00:06:03,710 --> 00:06:07,250
+shout yes you don't have to shout you don't have
+
+84
+00:06:07,250 --> 00:06:11,510
+to shout again now the negatives will use in the
+
+85
+00:06:11,510 --> 00:06:14,710
+negative must and have to have one different
+
+86
+00:06:14,710 --> 00:06:17,890
+meaning they have different meanings we said have
+
+87
+00:06:17,890 --> 00:06:21,430
+toand must when used in the positive they express
+
+88
+00:06:21,430 --> 00:06:25,810
+almost the same meanings though must can be a
+
+89
+00:06:25,810 --> 00:06:30,370
+little stronger but in the negative they have
+
+90
+00:06:30,370 --> 00:06:33,230
+different meanings they have different meanings
+
+91
+00:06:33,230 --> 00:06:37,370
+now look at we don't have to have to is the
+
+92
+00:06:37,370 --> 00:06:41,270
+negative of don't have to is the negative of have
+
+93
+00:06:41,270 --> 00:06:45,270
+to what do you understand? tomorrow there is a
+
+94
+00:06:45,270 --> 00:06:48,950
+holiday you don't have to comewhat does it mean
+
+95
+00:06:48,950 --> 00:06:53,790
+you don't have to come you don't need to come you
+
+96
+00:06:53,790 --> 00:06:58,130
+don't need to come now does it express a strong
+
+97
+00:06:58,130 --> 00:07:02,490
+necessity or obligation now thank you now look
+
+98
+00:07:02,490 --> 00:07:08,590
+lack of necessity may be expressed by what you
+
+99
+00:07:08,590 --> 00:07:14,250
+needn't now you needn't you needn't shout doctor
+
+100
+00:07:14,250 --> 00:07:15,530
+needn't care
+
+101
+00:07:18,260 --> 00:07:23,140
+Right? Now it acceptedها. Not is added to need.
+
+102
+00:07:24,020 --> 00:07:28,520
+Need here it is treated as an auxiliary verb. You
+
+103
+00:07:28,520 --> 00:07:32,660
+know auxiliary verbs can count. But God a lexical
+
+104
+00:07:32,660 --> 00:07:36,760
+verb doesn't accept the not. Right? So it accepted
+
+105
+00:07:36,760 --> 00:07:40,380
+the not. And this is accepted in British English.
+
+106
+00:07:41,290 --> 00:07:47,330
+what does it mean you needn't shout you
+
+107
+00:07:47,330 --> 00:07:54,110
+don't have to shout you don't have to worry you
+
+108
+00:07:54,110 --> 00:08:01,310
+don't have to worry thank you now so don't have to
+
+109
+00:08:01,310 --> 00:08:07,250
+means needed to or need not to sorry need not to
+
+110
+00:08:07,250 --> 00:08:12,100
+what about mustn'twhat about mustn't we said that
+
+111
+00:08:12,100 --> 00:08:16,880
+in the negative they have different meanings they
+
+112
+00:08:16,880 --> 00:08:22,340
+have different meanings I told you a secret you
+
+113
+00:08:22,340 --> 00:08:26,440
+mustn't tell anyone about that you mustn't tell
+
+114
+00:08:26,440 --> 00:08:29,880
+you mustn't tell her what you understand is it
+
+115
+00:08:29,880 --> 00:08:34,420
+allowed for her no it's not allowed for her it is
+
+116
+00:08:34,420 --> 00:08:39,660
+not allowed it is forbidden it is forbiddenمصنطل
+
+117
+00:08:39,660 --> 00:08:50,720
+مصنطل
+
+118
+00:08:50,720 --> 00:09:00,900
+مصنطل
+
+119
+00:09:00,900 --> 00:09:06,040
+مصنطل مصنطل مصنطل مصنطل
+
+120
+00:09:06,040 --> 00:09:07,740
+مصنطل مصنطل مصنطل مصنطل مصنطل مصنطل مصنطل مصنطل
+
+121
+00:09:07,740 --> 00:09:13,950
+مصنطل مصنطلالان هذا يعني مرة أخرى لا تخبر أحد عن
+
+122
+00:09:13,950 --> 00:09:20,530
+أسرائيه انا ممنعها ان تخبر أحد عن أسرائيه انها غير
+
+123
+00:09:20,530 --> 00:09:26,210
+مهمة انا ممنعك ان تفعلها انها تماما ممنعها الان
+
+124
+00:09:26,210 --> 00:09:30,570
+التعقيد المفارقة لا يجب أن تكون مثل ما نحن نحبه؟
+
+125
+00:09:30,570 --> 00:09:31,630
+مصدر
+
+126
+00:09:38,470 --> 00:09:44,570
+So we can express prohibition in other ways okay
+
+127
+00:09:44,570 --> 00:09:50,410
+you know must is .. must expresses strong
+
+128
+00:09:50,410 --> 00:09:54,430
+necessity or obligation and it is not necessary
+
+129
+00:09:54,430 --> 00:09:59,050
+always in all situations so if I want to express
+
+130
+00:09:59,050 --> 00:10:04,230
+prohibition I can use some other auxiliaries or I
+
+131
+00:10:04,230 --> 00:10:10,030
+can use some other ways for exampleDon't eat in
+
+132
+00:10:10,030 --> 00:10:15,930
+the class. Don't leave. Don't go out. This is
+
+133
+00:10:15,930 --> 00:10:20,030
+what؟ This is imperative. Order. I'm giving orders
+
+134
+00:10:20,030 --> 00:10:24,150
+okay. This is imperative okay. Don't go. Don't
+
+135
+00:10:24,150 --> 00:10:28,670
+leave. Don't eat. Don't talk in the class. Don't
+
+136
+00:10:28,670 --> 00:10:32,330
+tell anyone my secret. Does it express
+
+137
+00:10:32,330 --> 00:10:37,060
+apprehension? Yes, it does.but it is you know not
+
+138
+00:10:37,060 --> 00:10:42,680
+as strong as muscle okay now you can't tell anyone
+
+139
+00:10:42,680 --> 00:10:47,200
+you can't tell I forbid you also you can't tell
+
+140
+00:10:47,200 --> 00:10:52,080
+and you'd better not tell so what do you
+
+141
+00:10:52,080 --> 00:10:57,680
+understand must have to who can make a summary of
+
+142
+00:10:57,680 --> 00:11:02,590
+what we said yeah who can summarizeyes in the
+
+143
+00:11:02,590 --> 00:11:07,890
+negative yes خديجة there is some other models as
+
+144
+00:11:07,890 --> 00:11:11,970
+don't and can't and you'd better not it's express
+
+145
+00:11:11,970 --> 00:11:15,870
+prohibition and but it's not as strong as mustn't
+
+146
+00:11:15,870 --> 00:11:20,150
+good thank you because mustn't expresses strong
+
+147
+00:11:20,150 --> 00:11:24,310
+necessity or obligation okay mustn't also
+
+148
+00:11:24,310 --> 00:11:27,870
+expresses prohibition strong prohibitionit is not
+
+149
+00:11:27,870 --> 00:11:31,350
+always suitable in all the situations we can use
+
+150
+00:11:31,350 --> 00:11:34,630
+other models for example you can use the
+
+151
+00:11:34,630 --> 00:11:38,210
+imperative to express projection and what about
+
+152
+00:11:38,210 --> 00:11:44,170
+had to had to it's
+
+153
+00:11:44,170 --> 00:11:49,430
+the past of the have to and the need to okay thank
+
+154
+00:11:49,430 --> 00:11:53,390
+you and what about the negative of had toyou don't
+
+155
+00:11:53,390 --> 00:11:56,710
+have to you don't have to what's the difference
+
+156
+00:11:56,710 --> 00:12:00,430
+between you don't have to and you mustn't yes
+
+157
+00:12:00,430 --> 00:12:03,830
+please you mustn't expect me to do that but you
+
+158
+00:12:03,830 --> 00:12:07,490
+don't have to it's not you don't need to do it you
+
+159
+00:12:07,490 --> 00:12:10,190
+don't need thank you very much good now look at
+
+160
+00:12:10,190 --> 00:12:13,010
+this exercise complete the sentences with what
+
+161
+00:12:13,010 --> 00:12:22,400
+mustn't mustn't or doesn't have to do okayNow
+
+162
+00:12:22,400 --> 00:12:28,840
+number one so number one what do you think؟ yes
+
+163
+00:12:28,840 --> 00:12:35,100
+please in order to be a good sales clerk you
+
+164
+00:12:35,100 --> 00:12:38,560
+mustn't be rude to customers thank you why؟ you
+
+165
+00:12:38,560 --> 00:12:43,880
+are right but why؟ okay can you explain it why did
+
+166
+00:12:43,880 --> 00:12:44,800
+you choose it?
+
+167
+00:12:47,560 --> 00:12:52,740
+it is what? you know customers are very important
+
+168
+00:12:52,740 --> 00:12:57,320
+if we have customers we have business otherwise no
+
+169
+00:12:57,320 --> 00:13:00,120
+business without customers right? yes thank you
+
+170
+00:13:00,120 --> 00:13:03,280
+yes please you don't have to invest more money
+
+171
+00:13:03,280 --> 00:13:07,820
+than me to do grocery we have already did it no we
+
+172
+00:13:07,820 --> 00:13:10,560
+have already did it it means we know each other
+
+173
+00:13:10,560 --> 00:13:14,720
+right? yes so if we know each other is it needed?
+
+174
+00:13:18,650 --> 00:13:23,910
+don't don't have to have to good thank you what
+
+175
+00:13:23,910 --> 00:13:29,130
+about yes next one a person doesn't have to become
+
+176
+00:13:29,130 --> 00:13:32,030
+rich and famous in order to live a successful life
+
+177
+00:13:32,030 --> 00:13:36,390
+very good thank you can you explain that yes we
+
+178
+00:13:36,390 --> 00:13:41,170
+use doesn't because a person as a singular and it
+
+179
+00:13:41,170 --> 00:13:45,610
+is yes a lot of persons are successful but they
+
+180
+00:13:45,610 --> 00:13:46,450
+are not rich
+
+181
+00:13:50,180 --> 00:13:54,580
+yes please next one if you encounter a growling
+
+182
+00:13:54,580 --> 00:14:00,100
+dog you mustn't throw anything of fear if a dog
+
+183
+00:14:00,100 --> 00:14:06,640
+sees fear it is more likely to attack a person so
+
+184
+00:14:06,640 --> 00:14:09,920
+mustn't you are right good but why did you choose
+
+185
+00:14:09,920 --> 00:14:16,220
+this answer can you explain it because
+
+186
+00:14:16,220 --> 00:14:21,760
+it's a lesson yesلا اخر خيار، في هذه الحالة،
+
+187
+00:14:21,760 --> 00:14:26,480
+الشيطان .. الشيطان .. إذا كان الشيطان يشعر .. يشعر
+
+188
+00:14:26,480 --> 00:14:31,740
+.. يعرف أنك خائف ، فبالتأكيد سيهجم عليك ، لا اخر
+
+189
+00:14:31,740 --> 00:14:36,080
+خيار ، لذا يجب عليك أن تسحق ، يجب عليك أن تسحق ،
+
+190
+00:14:36,080 --> 00:14:42,080
+جيد ، نعم؟ تريدين أن تسأل؟ تريدين أن تسأل؟ رقم 5 ،
+
+191
+00:14:42,080 --> 00:14:43,060
+اتبعينه ، فقط انتظر
+
+192
+00:14:52,570 --> 00:14:56,210
+I go to the doctor and pretty much that I don't
+
+193
+00:14:56,210 --> 00:15:02,030
+have to I don't have to okay thank you I don't
+
+194
+00:15:02,030 --> 00:15:07,290
+have don't need to but yes to go to the doctor I
+
+195
+00:15:07,290 --> 00:15:10,890
+don't need thank you number seven number seven yes
+
+196
+00:15:10,890 --> 00:15:14,330
+please we don't have to go to the concert if you
+
+197
+00:15:14,330 --> 00:15:17,270
+don't want to to the concert yes we don't want to
+
+198
+00:15:17,270 --> 00:15:21,860
+but it's pretty much okay thank you we don't needو
+
+199
+00:15:21,860 --> 00:15:26,700
+أخيرًا .. و أخيرًا .. نعم أرجوك شخص لا يجب أن
+
+200
+00:15:26,700 --> 00:15:31,900
+يتزوج لكي يبقى سعيد و مفتوح شهر شهر شهر شهر شهر
+
+201
+00:15:31,900 --> 00:15:32,120
+شهر شهر شهر شهر شهر شهر شهر شهر شهر شهر شهر شهر
+
+202
+00:15:32,120 --> 00:15:33,120
+شهر شهر شهر شهر شهر شهر شهر شهر شهر شهر شهر شهر
+
+203
+00:15:33,120 --> 00:15:41,240
+شهر شهر شهر شهر شهر
+
+204
+00:15:41,240 --> 00:15:42,660
+شه
+
+205
+00:15:54,360 --> 00:15:58,840
+this is another exercise this is another exercise
+
+206
+00:15:58,840 --> 00:16:01,800
+let's discuss it together who wants to read the
+
+207
+00:16:01,800 --> 00:16:05,980
+introduction yes دعا read it read the situations
+
+208
+00:16:05,980 --> 00:16:09,360
+what advice would you give a Amir okay now what
+
+209
+00:16:09,360 --> 00:16:15,040
+advice will you give Amir okay or Amir okay what
+
+210
+00:16:15,040 --> 00:16:15,820
+advice would
+
+211
+00:16:21,750 --> 00:16:23,550
+عمير has a bag to take
+
+212
+00:16:28,600 --> 00:16:32,140
+what do you think وقع which situation which advice
+
+213
+00:16:32,140 --> 00:16:36,660
+is suitable for him number one he should see a
+
+214
+00:16:36,660 --> 00:16:40,440
+dentist immediately yes it's acceptable you think
+
+215
+00:16:40,440 --> 00:16:44,800
+this is a good advice yes thank you next one yes
+
+216
+00:16:44,800 --> 00:16:47,760
+please he should wait and see if the pain goes
+
+217
+00:16:47,760 --> 00:16:52,000
+away no no it's a good advice what do you think if
+
+218
+00:16:52,000 --> 00:16:56,780
+it is not a severe pain he should waitwhy not okay
+
+219
+00:16:56,780 --> 00:17:06,080
+yes again I think this is not .. he says a bad
+
+220
+00:17:06,080 --> 00:17:11,680
+thing he should okay wait and see if the pain was
+
+221
+00:17:11,680 --> 00:17:15,120
+away so it is possible it is possible he should
+
+222
+00:17:15,120 --> 00:17:20,400
+wait and see okay even some even if he has it
+
+223
+00:17:20,400 --> 00:17:25,620
+badly okayit is possible if it is possible this is
+
+224
+00:17:25,620 --> 00:17:30,540
+a we understand now what about number three yes
+
+225
+00:17:30,540 --> 00:17:34,920
+please money
+
+226
+00:17:34,920 --> 00:17:39,240
+for the ambulance okay then what about four yes
+
+227
+00:17:39,240 --> 00:17:44,210
+pleasehe should put an ice pack in his cheek too
+
+228
+00:17:44,210 --> 00:17:48,810
+that's right you know some people because ice will
+
+229
+00:17:48,810 --> 00:17:52,950
+reduce pain or may reduce pain good thank you yes
+
+230
+00:17:52,950 --> 00:17:57,270
+please he should take some pain medicine too do
+
+231
+00:17:57,270 --> 00:18:00,290
+you think you should take medicines without the
+
+232
+00:18:00,290 --> 00:18:03,630
+doctor no the doctor should okay give you the
+
+233
+00:18:03,630 --> 00:18:06,670
+medicine don't take medicines yourself okay and
+
+234
+00:18:06,670 --> 00:18:12,670
+finally نجوة he should give you an injectionno he
+
+235
+00:18:12,670 --> 00:18:17,290
+should get his cousin to pull the tooth right away
+
+236
+00:18:17,290 --> 00:18:21,010
+it's true true this is true if his cousin is a
+
+237
+00:18:21,010 --> 00:18:25,350
+dentist okay if his cousin is a dentist it's true
+
+238
+00:18:25,350 --> 00:18:30,310
+right if in case in case only if his cousin is a
+
+239
+00:18:30,310 --> 00:18:34,850
+dentist he can okay get his cousin to pull the
+
+240
+00:18:34,850 --> 00:18:36,510
+teeth or the tooth okay
+
+241
+00:18:42,530 --> 00:18:56,850
+الان انظر الى المساعدة الان نستخدم should او
+
+242
+00:18:56,850 --> 00:19:07,660
+to and had better لإعطائنا وقت كيف نستخدمها؟what's
+
+243
+00:19:07,660 --> 00:19:13,160
+the difference between them؟ now when I say you
+
+244
+00:19:13,160 --> 00:19:19,700
+should come early you ought to come early you
+
+245
+00:19:19,700 --> 00:19:25,540
+should come early you ought to come early what do
+
+246
+00:19:25,540 --> 00:19:29,560
+you think؟ now somebody .. she says that the
+
+247
+00:19:29,560 --> 00:19:35,060
+teacher is angry at me why؟ because I always
+
+248
+00:19:35,060 --> 00:19:41,210
+arrive latemy advice to you is to come early you
+
+249
+00:19:41,210 --> 00:19:47,850
+should come early or you ought to come early this
+
+250
+00:19:47,850 --> 00:19:53,290
+is I suggest .. I suggest something to a .. I
+
+251
+00:19:53,290 --> 00:19:58,070
+suggest .. to come early you come early to solve
+
+252
+00:19:58,070 --> 00:20:01,990
+this problem with the teacher right? so you know
+
+253
+00:20:01,990 --> 00:20:07,330
+it means here I advise .. sorryyou should come you
+
+254
+00:20:07,330 --> 00:20:10,770
+ought to come it means I advise you this is my
+
+255
+00:20:10,770 --> 00:20:14,770
+advice to you okay now look at this situation when
+
+256
+00:20:14,770 --> 00:20:18,670
+we say you should study harder and you ought to
+
+257
+00:20:18,670 --> 00:20:22,170
+study harder they mean what؟ it is a good ayah it
+
+258
+00:20:22,170 --> 00:20:26,230
+is a good ayah it is a good ayah this is my advice
+
+259
+00:20:26,230 --> 00:20:32,690
+I advise to you now you are coming to the
+
+260
+00:20:32,690 --> 00:20:38,570
+university with a taxiالسيارة السيارة تسرع كثير من
+
+261
+00:20:38,570 --> 00:20:48,070
+السرعة و أصبحت مخيفة و خائفة و قلت له السيارة يجب
+
+262
+00:20:48,070 --> 00:20:54,650
+أن تسرع بسرعة يجب أن تكون حذرا أو يجب أن تكون حذرا
+
+263
+00:20:54,650 --> 00:21:00,950
+ماذا تفكر؟Is it .. is it now advice in this
+
+264
+00:21:00,950 --> 00:21:04,750
+situation? No .. okay it is not advice that's
+
+265
+00:21:04,750 --> 00:21:10,250
+right what do you understand? important .. it's an
+
+266
+00:21:10,250 --> 00:21:13,830
+important responsibility okay it is important it
+
+267
+00:21:13,830 --> 00:21:17,530
+is your responsibility it is your duty or
+
+268
+00:21:17,530 --> 00:21:20,890
+responsibility okay it is your duty or
+
+269
+00:21:20,890 --> 00:21:21,910
+responsibility
+
+270
+00:21:24,840 --> 00:21:29,800
+abide with the traffic rules not to drive fast so
+
+271
+00:21:29,800 --> 00:21:36,860
+now had should study should do and ought to do the
+
+272
+00:21:36,860 --> 00:21:41,040
+meaning ranges it starts from making what a
+
+273
+00:21:41,040 --> 00:21:45,120
+suggestion you suggest something and it may be
+
+274
+00:21:45,120 --> 00:21:49,220
+stronger now in the case that this is a good idea
+
+275
+00:21:49,220 --> 00:21:54,350
+I advise you I suggest something for youbut when
+
+276
+00:21:54,350 --> 00:21:59,190
+you say you need to drive ahead you should drive
+
+277
+00:21:59,190 --> 00:22:04,450
+careful you should be slower you ought to this is
+
+278
+00:22:04,450 --> 00:22:07,590
+what you are reminding him of his responsibilities
+
+279
+00:22:07,590 --> 00:22:10,790
+you are responsible if something happens you are
+
+280
+00:22:10,790 --> 00:22:14,550
+you will be responsible okay so the meaning here
+
+281
+00:22:14,550 --> 00:22:19,210
+is what stronger the meaning is stronger so the
+
+282
+00:22:19,210 --> 00:22:26,930
+meaning of shouldand auto ranges from what to a
+
+283
+00:22:26,930 --> 00:22:31,570
+duty it is the same meaning it can start with a
+
+284
+00:22:31,570 --> 00:22:36,790
+simple suggestion okay giving advice giving
+
+285
+00:22:36,790 --> 00:22:42,190
+expressing that this is a good idea to her this is
+
+286
+00:22:42,190 --> 00:22:47,930
+your responsibility and it is important thing to
+
+287
+00:22:47,930 --> 00:22:50,490
+do it is important thing to do
+
+288
+00:22:56,800 --> 00:23:02,740
+read this sentence please you
+
+289
+00:23:02,740 --> 00:23:07,900
+shouldn't leave your keys in
+
+290
+00:23:07,900 --> 00:23:15,700
+the car okay go on shouldn't that's right now you
+
+291
+00:23:15,700 --> 00:23:19,480
+shouldn't leave your keys in the car you should
+
+292
+00:23:19,480 --> 00:23:25,150
+you shouldyou should study harder this is advice
+
+293
+00:23:25,150 --> 00:23:29,170
+right؟ نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+294
+00:23:29,170 --> 00:23:29,290
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+295
+00:23:29,290 --> 00:23:31,470
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+296
+00:23:31,470 --> 00:23:31,810
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+297
+00:23:31,810 --> 00:23:40,910
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+298
+00:23:40,910 --> 00:23:46,110
+نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم
+
+299
+00:23:46,110 --> 00:23:49,010
+نعم ن
+
+300
+00:23:51,780 --> 00:23:54,960
+I ought to oughta study in the tonight but I think
+
+301
+00:23:54,960 --> 00:23:58,760
+I'll watch TV instead. Native speakers often
+
+302
+00:23:58,760 --> 00:24:01,640
+pronounce ought to as oughta in informal speech.
+
+303
+00:24:02,280 --> 00:24:04,760
+Ought to is not commonly used in the negative if
+
+304
+00:24:04,760 --> 00:24:07,600
+it's .. if it is .. the to is sometimes ..
+
+305
+00:24:07,600 --> 00:24:11,080
+sometimes dropped. You ought not to leave the ..
+
+306
+00:24:11,080 --> 00:24:15,220
+your keys in the car. Thank you. Now in the
+
+307
+00:24:15,220 --> 00:24:18,680
+positive we use should .. you should study, you
+
+308
+00:24:18,680 --> 00:24:22,710
+should do, you should come.Okay you ought to but
+
+309
+00:24:22,710 --> 00:24:27,910
+in the negative should is more common okay ought
+
+310
+00:24:27,910 --> 00:24:30,970
+to is not commonly used in the negative and when
+
+311
+00:24:30,970 --> 00:24:34,330
+used in the negative to drop to yeah to is drop
+
+312
+00:24:34,330 --> 00:24:37,530
+you ought not leave you ought not leave but again
+
+313
+00:24:37,530 --> 00:24:45,390
+it is not very common now the gas the gas tank is
+
+314
+00:24:45,390 --> 00:24:52,640
+almost empty is almost empty gas meanspetrol
+
+315
+00:24:52,640 --> 00:24:58,940
+petrol okay for the car gas petrol for the car
+
+316
+00:24:58,940 --> 00:25:06,160
+okay now you had bitter stop at the next station
+
+317
+00:25:06,160 --> 00:25:11,260
+you had bitter you had bitter what you understand
+
+318
+00:25:11,260 --> 00:25:16,580
+from you had bitter now we talk about should okay
+
+319
+00:25:16,580 --> 00:25:24,690
+and oughtDo you think should or ought to is
+
+320
+00:25:24,690 --> 00:25:29,410
+suitable in this sentence؟ no you had better stop
+
+321
+00:25:29,410 --> 00:25:33,810
+it is stronger that's right thank you very much
+
+322
+00:25:33,810 --> 00:25:38,550
+you had better and you know if you don't stop
+
+323
+00:25:38,550 --> 00:25:42,690
+something bad will happen okay the car won't go
+
+324
+00:25:42,690 --> 00:25:50,630
+the car won't go now she has a deep cut in herهن
+
+325
+00:25:50,630 --> 00:25:59,590
+.. و انها تتردد تتردد تتردد تتردد تتردد تتردد
+
+326
+00:25:59,590 --> 00:26:08,450
+تتردد تتردد تتردد تتردد تتردد
+
+327
+00:26:08,450 --> 00:26:13,570
+تتردد
+
+328
+00:26:15,330 --> 00:26:19,250
+it means if we don't stop at a service station
+
+329
+00:26:19,250 --> 00:26:22,950
+there will be a bad result, we will run out of gas
+
+330
+00:26:22,950 --> 00:26:25,570
+very good, we run out of gas, thank you
+
+331
+00:26:31,960 --> 00:26:37,060
+لأ ينفد ينفد
+
+332
+00:26:37,060 --> 00:26:46,860
+ينفد ينفد ينفد ينفد ينفد ينفد ينفد ينفد ينفد ينفد
+
+333
+00:26:46,860 --> 00:26:48,700
+ينفد ينفد ينفد ينفد ينفد
+
+334
+00:26:55,760 --> 00:26:59,300
+you had better go you had better stop if you don't
+
+335
+00:26:59,300 --> 00:27:02,720
+go there will be a bad result the car won't walk
+
+336
+00:27:02,720 --> 00:27:08,200
+yes go on please قم ليك you had better take care
+
+337
+00:27:08,200 --> 00:27:11,460
+of that cut on your hand soon or it will get
+
+338
+00:27:11,460 --> 00:27:15,360
+infected yes you had better take care if you don't
+
+339
+00:27:15,360 --> 00:27:19,300
+take care it will get what infected something bad
+
+340
+00:27:19,300 --> 00:27:23,190
+again will happen yes go on please readit means
+
+341
+00:27:23,190 --> 00:27:27,410
+habitter is close to should and ought to but
+
+342
+00:27:27,410 --> 00:27:30,350
+habitter is usually stronger that's right it is
+
+343
+00:27:30,350 --> 00:27:33,870
+stronger it is a clause it expresses what? her
+
+344
+00:27:33,870 --> 00:27:39,950
+personality okay and expresses also what? slow ..
+
+345
+00:27:39,950 --> 00:27:44,650
+yeah sometimes yes warning you are warning someone
+
+346
+00:27:44,650 --> 00:27:50,010
+as if go on please often habitter implies a
+
+347
+00:27:50,010 --> 00:27:53,990
+warningor a fruit of possible bad consequences
+
+348
+00:27:53,990 --> 00:27:57,630
+possible bad consequences something bad will
+
+349
+00:27:57,630 --> 00:28:01,770
+happen okay you had bitter study if you had bitter
+
+350
+00:28:01,770 --> 00:28:05,010
+study it means if you don't study you won't pass
+
+351
+00:28:05,010 --> 00:28:09,090
+okay you had but you should study I'm giving
+
+352
+00:28:09,090 --> 00:28:14,110
+advice okay I'm giving advice I suggest something
+
+353
+00:28:14,110 --> 00:28:18,750
+good now notes read the notes please notes on the
+
+354
+00:28:18,750 --> 00:28:22,260
+use of had been doneit has a present or future
+
+355
+00:28:22,260 --> 00:28:25,920
+meaning okay like what and could could you close
+
+356
+00:28:25,920 --> 00:28:31,020
+the door could you okay bring me it is yeah
+
+357
+00:28:31,020 --> 00:28:34,980
+present or future it is followed by the simple
+
+358
+00:28:34,980 --> 00:28:39,060
+form of a verb you better go you better study you
+
+359
+00:28:39,060 --> 00:28:42,900
+better see god it's more common in speaking than
+
+360
+00:28:42,900 --> 00:28:47,540
+writing so it is informal okay it is more informal
+
+361
+00:28:47,540 --> 00:28:51,490
+than the othersit is more informal than that now
+
+362
+00:28:51,490 --> 00:29:03,850
+must sorry should should ought
+
+363
+00:29:03,850 --> 00:29:14,710
+to and what had better okay and had better now
+
+364
+00:29:14,710 --> 00:29:20,030
+كلمةWhat about them? What do you know about them?
+
+365
+00:29:20,250 --> 00:29:23,510
+Can you make a summary? Who wants to talk about
+
+366
+00:29:23,510 --> 00:29:28,790
+them? Who wants? Yes please. All these webs use
+
+367
+00:29:28,790 --> 00:29:33,790
+about advice but then other stronger than advice
+
+368
+00:29:33,790 --> 00:29:37,690
+should use hers because it's the most stronger
+
+369
+00:29:37,690 --> 00:29:43,330
+than other and then should also in advice. Thank
+
+370
+00:29:43,330 --> 00:29:47,390
+you. This is in the negative.and this is more
+
+371
+00:29:47,390 --> 00:29:52,170
+common, shouldn't is more common than and had
+
+372
+00:29:52,170 --> 00:29:57,150
+better is what؟ it is the strongest but it is
+
+373
+00:29:57,150 --> 00:29:58,810
+what؟ informal
+
+374
+00:30:09,550 --> 00:30:13,290
+this is contraction small form you'd better take
+
+375
+00:30:13,290 --> 00:30:18,050
+care of it you'd better you'd better you'd better
+
+376
+00:30:18,050 --> 00:30:19,910
+you'd better you'd better you'd better you'd
+
+377
+00:30:19,910 --> 00:30:22,810
+better you'd better you'd better you'd better
+
+378
+00:30:22,810 --> 00:30:24,890
+you'd better you'd better you'd better you'd
+
+379
+00:30:24,890 --> 00:30:25,310
+better you'd better you'd better you'd better
+
+380
+00:30:25,310 --> 00:30:25,350
+you'd better you'd better you'd better you'd
+
+381
+00:30:25,350 --> 00:30:25,510
+better you'd better you'd better you'd better
+
+382
+00:30:25,510 --> 00:30:28,070
+you'd better you'd better you'd better you'd
+
+383
+00:30:28,070 --> 00:30:29,230
+you'd better you'd better you'd better you'd
+
+384
+00:30:29,230 --> 00:30:29,350
+better you'd better you'd better you'd better
+
+385
+00:30:29,350 --> 00:30:29,430
+you'd better you'd better you'd better you'd
+
+386
+00:30:29,430 --> 00:30:30,050
+you'd better you'd better you'd better you'd
+
+387
+00:30:30,050 --> 00:30:33,220
+better you'dthis is in speech, we say had better
+
+388
+00:30:33,220 --> 00:30:37,160
+is used in spoken language, right? more than in
+
+389
+00:30:37,160 --> 00:30:41,020
+writing, so in spoken even had is dropped, it's
+
+390
+00:30:41,020 --> 00:30:44,720
+gone you had better not be there, negative form
+
+391
+00:30:44,720 --> 00:30:47,500
+had better plus not thank you, so it can be also
+
+392
+00:30:47,500 --> 00:30:51,060
+used in that negative form look at this exercise
+
+393
+00:30:51,060 --> 00:30:56,080
+complete the dialogues with your own words use
+
+394
+00:30:56,080 --> 00:30:59,940
+should, ought to or had better to
+
+395
+00:31:02,530 --> 00:31:07,830
+number one number one would you read please read
+
+396
+00:31:07,830 --> 00:31:12,610
+it yes
+
+397
+00:31:12,610 --> 00:31:19,850
+you don't fit you should return it thank you you
+
+398
+00:31:19,850 --> 00:31:24,470
+should return it good next one yes please read it
+
+399
+00:31:24,470 --> 00:31:28,690
+have you gotten your airplane ticket no not yet
+
+400
+00:31:28,690 --> 00:31:33,800
+the flights fill up fastnear the holidays, you
+
+401
+00:31:33,800 --> 00:31:36,680
+must take one another. very good, this is a
+
+402
+00:31:36,680 --> 00:31:38,920
+stronger definition okay. you had better, you had
+
+403
+00:31:38,920 --> 00:31:42,660
+better, you had better, you had better, you had
+
+404
+00:31:42,660 --> 00:31:43,960
+better, you had better, you had better, you had
+
+405
+00:31:43,960 --> 00:31:45,420
+better, you had better, you had better, you had
+
+406
+00:31:45,420 --> 00:31:45,780
+better, you had better, you had better, you had
+
+407
+00:31:45,780 --> 00:31:46,160
+better, you had better, you had better, you had
+
+408
+00:31:46,160 --> 00:31:46,540
+better, you had better, you had better, you had
+
+409
+00:31:46,540 --> 00:31:52,560
+better, you had better, you had better, you had
+
+410
+00:31:52,560 --> 00:31:54,480
+better, you had better, you had better, you had
+
+411
+00:31:54,480 --> 00:31:54,520
+better, you had better, you had better, you had
+
+412
+00:31:54,520 --> 00:31:56,640
+better, you had betterstronger we want stronger
+
+413
+00:31:56,640 --> 00:32:00,520
+necessity or obligation or advisability next one
+
+414
+00:32:00,520 --> 00:32:06,520
+yes please yes it's my class starts in five
+
+415
+00:32:06,520 --> 00:32:10,220
+minutes I wasn't watching the time you should go
+
+416
+00:32:10,220 --> 00:32:13,660
+to the class now thank you you should hurry up you
+
+417
+00:32:13,660 --> 00:32:18,280
+should hurry up next one number four I don't
+
+418
+00:32:18,280 --> 00:32:18,860
+understand
+
+419
+00:32:22,240 --> 00:32:24,420
+who can read it? who knows this word?
+
+420
+00:32:27,720 --> 00:32:38,200
+go on you should see a doctor you
+
+421
+00:32:38,200 --> 00:32:42,740
+should have some water thank you next one number
+
+422
+00:32:42,740 --> 00:32:45,380
+five number five
+
+423
+00:32:51,840 --> 00:32:57,480
+yes meal read it I bought these organic apples and
+
+424
+00:32:57,480 --> 00:33:02,320
+all of them are written inside you should return
+
+425
+00:33:02,320 --> 00:33:06,580
+them you should return them thank you or buy
+
+426
+00:33:06,580 --> 00:33:10,880
+others if you have much money buy others and if
+
+427
+00:33:10,880 --> 00:33:14,380
+you don't have much money you should return them
+
+428
+00:33:14,380 --> 00:33:19,400
+goodالان انظر إلى التعليم مرة أخرى، قم بقراءة
+
+429
+00:33:19,400 --> 00:33:24,660
+الانتقال، أرجوك. أي كلمة في كل مجموعة أقوى؟ أجل،
+
+430
+00:33:24,660 --> 00:33:28,660
+كل كلمة أقوى أقوى، أجل. اتكلم عن الحالة التي يمكن
+
+431
+00:33:28,660 --> 00:33:34,740
+أن يقول الحكومة هذه الكلمة؟ أجل، ما هي الحالة؟Each
+
+432
+00:33:34,740 --> 00:33:38,520
+sentence can be said. Will you start number one?
+
+433
+00:33:38,900 --> 00:33:43,200
+You should go to a doctor. You had better go to a
+
+434
+00:33:43,200 --> 00:33:46,500
+doctor. And which is stronger? The first one when
+
+435
+00:33:46,500 --> 00:33:55,440
+his pain is not dangerous. Okay, not dangerous,
+
+436
+00:33:55,620 --> 00:33:58,420
+not serious. And the other one? If it's awful or
+
+437
+00:33:58,420 --> 00:34:01,020
+dangerous, strong dangerous. Okay, a dangerous
+
+438
+00:34:01,020 --> 00:34:04,630
+situation.so I understand that you want to say B
+
+439
+00:34:04,630 --> 00:34:09,370
+is stronger right? thank you good this is stronger
+
+440
+00:34:09,370 --> 00:34:14,190
+next one yes please marry should go to war today,
+
+441
+00:34:14,310 --> 00:34:16,930
+marry must go to war today, marry must
+
+442
+00:34:21,210 --> 00:34:25,950
+next one we've got to go to class, we ought to go
+
+443
+00:34:25,950 --> 00:34:29,170
+to class, we ought to go to class which is
+
+444
+00:34:29,170 --> 00:34:33,150
+stronger? we have got to go or we ought to go?
+
+445
+00:34:33,970 --> 00:34:38,290
+just wait there is one speaker yeah what do you
+
+446
+00:34:38,290 --> 00:34:42,310
+think? we have got to go or we ought to go? you
+
+447
+00:34:42,310 --> 00:34:48,930
+remember? should? ought to advice okay so this is
+
+448
+00:34:48,930 --> 00:34:55,370
+strongerthis is stronger thank you yes please I
+
+449
+00:34:55,370 --> 00:34:59,390
+have to go
+
+450
+00:34:59,390 --> 00:35:04,410
+but I
+
+451
+00:35:04,410 --> 00:35:08,450
+should what do you think there is one speaker give
+
+452
+00:35:08,450 --> 00:35:12,810
+her a chance I'm discussing it with Samara Samara
+
+453
+00:35:12,810 --> 00:35:13,590
+what do you think
+
+454
+00:35:21,340 --> 00:35:24,660
+I have to A is stronger you are right thank you
+
+455
+00:35:24,660 --> 00:35:29,980
+this is stronger number five yes please we
+
+456
+00:35:29,980 --> 00:35:32,960
+shouldn't go to that room and we mustn't go to
+
+457
+00:35:32,960 --> 00:35:38,180
+that room because they are dangerous thank you and
+
+458
+00:35:38,180 --> 00:35:44,420
+finally finally yesكنت بتر .. not be .. not be
+
+459
+00:35:44,420 --> 00:35:48,040
+other around .. you shouldn't be other around ايه
+
+460
+00:35:48,040 --> 00:35:52,820
+ايه ايه ايه ايه ايه ايه ايه ايه ايه ايه ايه ايه
+
+461
+00:35:52,820 --> 00:35:54,040
+ايه ايه ايه ايه ايه ايه ايه ايه ايه ايه ايه ايه
+
+462
+00:35:54,040 --> 00:35:54,160
+ايه ايه ايه ايه ايه ايه ايه ايه ايه ايه ايه ايه
+
+463
+00:35:54,160 --> 00:35:54,900
+ايه ايه ايه ايه ايه ايه ايه ايه ايه ايه ايه ايه
+
+464
+00:35:54,900 --> 00:36:10,280
+ايه ايه ايه ايه ايه ايه ايه
+
+465
+00:36:10,280 --> 00:36:18,260
+اyes please start read the introduction so
+
+466
+00:36:18,260 --> 00:36:22,160
+we
+
+467
+00:36:22,160 --> 00:36:25,600
+may have more than one right answer go on number
+
+468
+00:36:25,600 --> 00:36:36,390
+one must is good a good answer yesI have two is a
+
+469
+00:36:36,390 --> 00:36:39,590
+good answer thank you number two I don't have
+
+470
+00:36:39,590 --> 00:36:42,430
+enough money to take the bus so I have to walk
+
+471
+00:36:42,430 --> 00:36:47,990
+home I have two I have two thank you very much
+
+472
+00:37:17,210 --> 00:37:22,090
+مش مش نصيحةwhat do you think what about have to
+
+473
+00:37:22,090 --> 00:37:27,330
+and must they are also possible okay but this is
+
+474
+00:37:27,330 --> 00:37:34,990
+better but this is better next one okay
+
+475
+00:37:34,990 --> 00:37:40,470
+I have to but you know according to my advisor I
+
+476
+00:37:40,470 --> 00:37:45,890
+think should is better but also have to and must
+
+477
+00:37:45,890 --> 00:37:50,090
+are acceptedThank you. Please try it. Yeah, next
+
+478
+00:37:50,090 --> 00:37:54,190
+one. A rice must have water in order to grow.
+
+479
+00:37:54,510 --> 00:37:59,990
+Thank you. All has to. Must. All has to. Good. And
+
+480
+00:37:59,990 --> 00:38:05,670
+next one. The pie is very good. You should try at
+
+481
+00:38:05,670 --> 00:38:09,350
+least one. No. Yes. Uh-huh. You should. You
+
+482
+00:38:09,350 --> 00:38:14,920
+should. You should try. Good. Yes, you should.you
+
+483
+00:38:14,920 --> 00:38:22,600
+should try and finally you must look up you must
+
+484
+00:38:22,600 --> 00:38:29,220
+look up very good you should excellent you must
+
+485
+00:38:29,220 --> 00:38:32,520
+and now we can say goodbye thank you very much for
+
+486
+00:38:32,520 --> 00:38:32,820
+today
+
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/xazbodbx1wc_raw.srt b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/xazbodbx1wc_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..f79dad78b854b88aa43f1c3098967b6889ac9b45
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/xazbodbx1wc_raw.srt
@@ -0,0 +1,1676 @@
+1
+00:00:21,400 --> 00:00:28,960
+السلام عليكم جيد الصباح لكم جميعًا كيف حالك؟ كيف
+
+2
+00:00:28,960 --> 00:00:36,220
+تشعر اليوم؟ بعد الشمس و الظلمات؟ تشعر بخير؟ تحفظ؟
+
+3
+00:00:36,220 --> 00:00:41,500
+حسنًا ماذا؟
+
+4
+00:00:50,030 --> 00:00:58,070
+موريدا مجففة ماريدا
+
+5
+00:00:58,070 --> 00:00:58,770
+مجففة ماريدا مجففة ماريدا مجففة ماريدا مجففة
+
+6
+00:00:58,770 --> 00:01:07,050
+ماريدا مجففة ماريدا مجففة ماريدا مجففةOkay you
+
+7
+00:01:07,050 --> 00:01:12,870
+should wear
+
+8
+00:01:12,870 --> 00:01:16,290
+heavy clothes thank you good yeah she should have
+
+9
+00:01:16,290 --> 00:01:21,850
+worn a jacket now we need your sentence but after
+
+10
+00:01:21,850 --> 00:01:24,070
+some minutes we will come back again to your
+
+11
+00:01:24,070 --> 00:01:30,690
+sentence khadija okay now tomorrow the weather
+
+12
+00:01:30,690 --> 00:01:35,170
+will be cold also tomorrow tomorrow the weather
+
+13
+00:01:35,170 --> 00:01:40,830
+will be coldwhat do you suggest what do you
+
+14
+00:01:40,830 --> 00:01:46,390
+suggest yeah I suggest we stay at home it's enough
+
+15
+00:01:46,390 --> 00:01:52,350
+staying at home okay so good she says I suggest we
+
+16
+00:01:52,350 --> 00:01:56,570
+stay at home can you say that in another way yeah
+
+17
+00:01:57,870 --> 00:02:00,770
+that's right and also you can say why don't we
+
+18
+00:02:00,770 --> 00:02:07,250
+stay at home okay we could stay at home right we
+
+19
+00:02:07,250 --> 00:02:11,390
+could stay at home why don't we stay at home now
+
+20
+00:02:11,390 --> 00:02:16,310
+if you look why don't we and we could they offer
+
+21
+00:02:16,310 --> 00:02:21,740
+you the same meaningهم تستخدمون لماذا؟ لتعملوا
+
+22
+00:02:21,740 --> 00:02:26,780
+إقتراح، صحيح؟ أنت تقترح شيء، لذا تقول ماذا؟ لماذا
+
+23
+00:02:26,780 --> 00:02:32,440
+لا نأكل و نستطيع؟ قد في هذه الحالة تستخدم لتعمل
+
+24
+00:02:32,440 --> 00:02:37,200
+إقتراح، صحيح؟ أنا غاضب، ماذا تقترح؟
+
+25
+00:02:39,550 --> 00:02:43,210
+انا غاضب انا لم احب الصباح. لماذا لا تأكل صندوق؟
+
+26
+00:02:43,210 --> 00:02:47,870
+شكرا جميل. يمكنك أن تأكل صندوق. شكرا جزيلا. يمكنك
+
+27
+00:02:47,870 --> 00:02:52,150
+أن تأكل صندوق. لماذا لا تأكل صندوق؟ حسنا، هذا
+
+28
+00:02:52,150 --> 00:02:57,670
+صحيح. الآن إذا أقول أنك يجب أن تأكل صندوق، يجب أن
+
+29
+00:02:57,670 --> 00:03:02,810
+توقف الآن، يجب أن تذهب الآن.this is what type of
+
+30
+00:03:02,810 --> 00:03:05,470
+language function does this situation or this
+
+31
+00:03:05,470 --> 00:03:10,870
+sentence express you should eat at home before you
+
+32
+00:03:10,870 --> 00:03:15,050
+leave yes أسماء okay thank you very much strong
+
+33
+00:03:15,050 --> 00:03:19,130
+advice good that's right strong advice now which
+
+34
+00:03:19,130 --> 00:03:24,960
+is bitterlisten you should have something at home
+
+35
+00:03:24,960 --> 00:03:29,560
+or maybe you should have something at home which
+
+36
+00:03:29,560 --> 00:03:33,540
+one do you like more maybe you should eat at your
+
+37
+00:03:33,540 --> 00:03:37,660
+breakfast or you should eat your breakfast which
+
+38
+00:03:37,660 --> 00:03:44,580
+one do you like more you should maybe why maybe
+
+39
+00:03:44,580 --> 00:03:47,180
+not you should okay
+
+40
+00:03:49,690 --> 00:03:54,970
+Okay it softens maybe softens the strength of the
+
+41
+00:03:54,970 --> 00:04:00,030
+advice okay thank you very much now as we said you
+
+42
+00:04:00,030 --> 00:04:03,870
+should this expresses what a strong advice but if
+
+43
+00:04:03,870 --> 00:04:08,190
+you want to soften as a matter of respect you want
+
+44
+00:04:08,190 --> 00:04:11,430
+to respect or to let the other side accept your
+
+45
+00:04:11,430 --> 00:04:15,710
+advice you say maybe you should okay maybe you
+
+46
+00:04:15,710 --> 00:04:18,810
+should now
+
+47
+00:04:19,700 --> 00:04:23,220
+انظر لهذه السلسلة انا في مشكلة في مدرسة الرياضة
+
+48
+00:04:23,220 --> 00:04:36,260
+انا في مشكلة هذا مشكلة هذا مشكلة انا في مشكلة
+
+49
+00:04:36,260 --> 00:04:38,540
+هذا مشكلة هذا مشكلة هذا مشكلة هذا مشكلة هذا مشكلة
+
+50
+00:04:38,540 --> 00:04:38,540
+هذا مشكلة هذا مشكلة هذا مشكلة هذا مشكلة هذا مشكلة
+
+51
+00:04:38,540 --> 00:04:38,540
+هذا مشكلة هذا مشكلة هذا مشكلة هذا مشكلة هذا مشكلة
+
+52
+00:04:38,540 --> 00:04:39,960
+هذا مشكلة هذا مشكلة هذا مشكلة هذا مشكلة هذا مشكلة
+
+53
+00:04:39,960 --> 00:04:40,380
+هذا مشكلة هذا مشكلة هذا مشكلة هذا مشكلة هذا مشكلة
+
+54
+00:04:40,380 --> 00:04:40,380
+هذا مشكلة هذا مشكلة هذا مشكلة هذا مشكلة هذا مشكلة
+
+55
+00:04:40,380 --> 00:04:40,620
+هذا مشكلة هذا مشكلة هذا مشكلة هذا مشكلة هذا مشكلة
+
+56
+00:04:40,620 --> 00:04:40,620
+هذا مشكلة هذا مشكلة هذا مشكلة هذا مشكلة هذا مشكلة
+
+57
+00:04:40,620 --> 00:04:46,540
+هذا مشكلة هذا مشكلة هذا مشكلة هذا مشكلة هذا مشكل
+
+58
+00:04:47,460 --> 00:04:52,860
+ماذا يعني ذلك؟ او
+
+59
+00:04:52,860 --> 00:05:00,960
+ممكنة، هذا صحيح، انا اقترح شيء و هو ممكن، ممكنة
+
+60
+00:05:00,960 --> 00:05:05,100
+واحدة هي ان تفعل هذا و ممكنة أخرى هي ان تفعل ذلك و
+
+61
+00:05:05,100 --> 00:05:11,620
+هكذا، الآن مرة أخرى أحياناً قد يتم استخدامها،
+
+62
+00:05:11,620 --> 00:05:17,250
+يمكنك أن تتكلم مع أستاذكyou might you might go now
+
+63
+00:05:17,250 --> 00:05:21,070
+this is another way of what of making suggestion
+
+64
+00:05:21,070 --> 00:05:24,790
+but may is not used in this situation might yeah
+
+65
+00:05:24,790 --> 00:05:30,290
+you can use could and might is also used look i
+
+66
+00:05:30,290 --> 00:05:37,110
+failed my math class i failed my math class now
+
+67
+00:05:37,110 --> 00:05:44,800
+you rememberأنها تشعر بالحرارة جدا وخديجة أخبرتها
+
+68
+00:05:44,800 --> 00:05:50,860
+أنك يجب أن تحرر جسدك أو قطعك ماذا تفكر بهذا
+
+69
+00:05:50,860 --> 00:05:55,340
+الادعاء؟ الان هي في المدرسة، هل يمكنها أن تحصل على
+
+70
+00:05:55,340 --> 00:06:02,660
+قطعها؟ لا، ليس ممكن، حسنًا؟ ليس ممكن لها أن تحصل
+
+71
+00:06:02,660 --> 00:06:08,890
+على القطع، لا، هل تعتقد أن هذا الادعاءأتت في الوقت
+
+72
+00:06:08,890 --> 00:06:13,030
+الصحيح؟ لا، أتت .. آه .. آه .. آه .. آه .. آه ..
+
+73
+00:06:13,030 --> 00:06:13,590
+آه .. آه .. آه .. آه .. آه .. آه .. آه .. آه .. آه
+
+74
+00:06:13,590 --> 00:06:15,690
+.. آه .. آه .. آه .. آه .. آه .. آه .. آه .. آه ..
+
+75
+00:06:15,690 --> 00:06:16,090
+آه .. آه .. آه .. آه .. آه .. آه .. آه .. آه .. آه
+
+76
+00:06:16,090 --> 00:06:18,430
+.. آه .. آه .. آه .. آه .. آه .. آه .. آه .. آه ..
+
+77
+00:06:18,430 --> 00:06:18,450
+آه .. آه .. آه .. آه .. آه .. آه .. آه .. آه .. آه
+
+78
+00:06:18,450 --> 00:06:18,530
+.. آه .. آه .. آه .. آه .. آه .. آه .. آه .. آه ..
+
+79
+00:06:18,530 --> 00:06:18,530
+آه .. آه .. آه .. آه .. آه .. آه .. آه .. آه .. آه
+
+80
+00:06:18,530 --> 00:06:26,190
+.. آه .. آه .. آه
+
+81
+00:06:26,190 --> 00:06:33,230
+.. آه
+
+82
+00:06:33,660 --> 00:06:37,580
+it is too late to give advice right? so this is
+
+83
+00:06:37,580 --> 00:06:42,240
+called what? hindsight advice you didn't do well
+
+84
+00:06:42,240 --> 00:06:46,180
+in the exam you should have studied carefully
+
+85
+00:06:46,180 --> 00:06:51,780
+okay? now it is too late so this type of advice
+
+86
+00:06:51,780 --> 00:06:57,700
+you should have talked it is a past advice but it
+
+87
+00:06:57,700 --> 00:07:05,040
+came in a late timeوكان من المهم لك أن تتكلم لكنك
+
+88
+00:07:05,040 --> 00:07:10,820
+لم تفعل ذلك لقد قمت بخطأ كانت خطأك لأنك لم تتكلم
+
+89
+00:07:10,820 --> 00:07:17,100
+مع أستاذك الان
+
+90
+00:07:17,100 --> 00:07:23,740
+دعاء لم يحضر عصابته عصابته كانت عصابته عارفة جدا
+
+91
+00:07:23,740 --> 00:07:25,900
+ماذا تقول للدعاء؟
+
+92
+00:07:29,990 --> 00:07:32,530
+she should have brought that's right thank you
+
+93
+00:07:32,530 --> 00:07:36,550
+very much she should have brought okay another is
+
+94
+00:07:36,550 --> 00:07:41,750
+hungry she didn't have breakfast at home yeah she
+
+95
+00:07:41,750 --> 00:07:44,010
+should have eaten her breakfast very good she
+
+96
+00:07:44,010 --> 00:07:49,410
+should have eaten her breakfast okay yeah
+
+97
+00:07:49,410 --> 00:07:53,650
+what do you want okay look at the situation okay
+
+98
+00:07:53,650 --> 00:07:58,060
+read itI failed my math class I failed my math
+
+99
+00:07:58,060 --> 00:08:01,780
+class this is another problem yeah you could have
+
+100
+00:08:01,780 --> 00:08:04,320
+talked to your teacher or you could have asked ana
+
+101
+00:08:04,320 --> 00:08:07,040
+to help you with your math or I could have tried
+
+102
+00:08:07,040 --> 00:08:10,380
+to help you it means you had the chance to do this
+
+103
+00:08:10,380 --> 00:08:13,080
+or that it was possible for this or that to happen
+
+104
+00:08:13,080 --> 00:08:15,620
+you missed some good opportunities thank you very
+
+105
+00:08:15,620 --> 00:08:19,080
+much now you could have talked it was a good
+
+106
+00:08:19,080 --> 00:08:23,970
+chance you missed itor you could have asked, you
+
+107
+00:08:23,970 --> 00:08:27,110
+didn't ask, it was a good chance and you missed it
+
+108
+00:08:27,110 --> 00:08:34,530
+or I could have triedلديك فرصة جيدة ممكنة جديدة
+
+109
+00:08:34,530 --> 00:08:40,550
+ولكنك لم تفعلها لقد فشلت كل الفرصة كانت فرصة جيدة
+
+110
+00:08:40,550 --> 00:08:47,510
+لك ولكنك لم تفعلها انت تعرف انها جاءت متأخرة مرة
+
+111
+00:08:47,510 --> 00:08:51,610
+أخرى هل تتذكر ان في الحالة السابقة قلنا انه يجب أن
+
+112
+00:08:51,610 --> 00:08:54,410
+يكون لديك طعام يجب أن يكون لديك برات يجب أن يكون
+
+113
+00:08:54,410 --> 00:08:54,750
+لديك طعام
+
+114
+00:08:57,630 --> 00:09:02,190
+بإمكانك أن تكون قصة تظهر الوقت بإمكانية لكن هل في
+
+115
+00:09:02,190 --> 00:09:07,330
+الوقت الصحيح؟ لا ، فهو ماذا؟ حيثية ، إمكانية ، إنه
+
+116
+00:09:07,330 --> 00:09:12,690
+متأخر ، حسنًا ، انظر إلى هذا التعليق ، هل تقرأ
+
+117
+00:09:12,690 --> 00:09:15,290
+الانتقال، أرجوك ، نعم
+
+118
+00:09:23,570 --> 00:09:29,370
+الان يجب و يمكن ان يكون استخدامه الان ماذا يظهر؟
+
+119
+00:09:29,370 --> 00:09:35,330
+هل يظهر فرصة؟ هل يظهر أدب؟ و ماهي الفرصة؟ او ماهي
+
+120
+00:09:35,330 --> 00:09:36,110
+الفرصة؟ او ماهي الفرصة؟ او ماهي الفرصة؟ او ماهي
+
+121
+00:09:36,110 --> 00:09:36,610
+الفرصة؟ او ماهي الفرصة؟ او ماهي الفرصة؟ او ماهي
+
+122
+00:09:36,610 --> 00:09:39,990
+الفرصة؟ او ماهي الفرصة؟ او ماهي الفرصة؟ او ماهي
+
+123
+00:09:39,990 --> 00:09:39,990
+الفرصة؟ او ماهي الفرصة؟ او ماهي الفرصة؟ او ماهي
+
+124
+00:09:39,990 --> 00:09:46,490
+الفرصة؟ او ماهي الفرصة؟ او ماهي الفرصة؟ او ماهي
+
+125
+00:09:46,490 --> 00:09:53,190
+الفرصة؟ او ماهي الفرصhe could call a doctor he
+
+126
+00:09:53,190 --> 00:09:57,970
+could call doctor sang or he could call doctor
+
+127
+00:09:57,970 --> 00:10:02,190
+jones or he could simply stay in bed for a day and
+
+128
+00:10:02,190 --> 00:10:05,710
+hope he feels better tomorrow thank you now what
+
+129
+00:10:05,710 --> 00:10:08,610
+do you think he should do should what does it
+
+130
+00:10:08,610 --> 00:10:12,950
+express advice yes thank you he should see
+
+131
+00:10:12,950 --> 00:10:20,330
+expressesa strong advice a strong advice good he
+
+132
+00:10:20,330 --> 00:10:24,350
+could call he could call what does it express yeah
+
+133
+00:10:24,350 --> 00:10:29,630
+again let's complete let's complete look at this
+
+134
+00:10:29,630 --> 00:10:33,330
+sentence he could stay he could call expresses
+
+135
+00:10:33,330 --> 00:10:39,890
+what okay he could call he could stay expresses
+
+136
+00:10:39,890 --> 00:10:46,170
+yes who is the speakerthank you very much good now
+
+137
+00:10:46,170 --> 00:10:51,610
+number two number two yeah we want three students
+
+138
+00:10:51,610 --> 00:10:57,590
+ABC go on ABC go on I need to get to the airport
+
+139
+00:10:57,590 --> 00:11:01,490
+you should take the airport bus but it's cheaper
+
+140
+00:11:01,490 --> 00:11:05,590
+than a taxi it's cheaper than a taxi well you
+
+141
+00:11:05,590 --> 00:11:09,150
+could you could take the airport bus or you could
+
+142
+00:11:09,150 --> 00:11:10,570
+take a taxi maybe
+
+143
+00:11:13,610 --> 00:11:19,870
+thank you now look you are still at home you want
+
+144
+00:11:19,870 --> 00:11:24,530
+to go to the airport okay you should take this is
+
+145
+00:11:24,530 --> 00:11:27,930
+what what does it express what does it express
+
+146
+00:11:27,930 --> 00:11:34,540
+yeah thank you you could takeفرصة جيدة تستطيع أن
+
+147
+00:11:34,540 --> 00:11:37,080
+تأخذ .. تستطيع أن تأخذ الاسبريكس و؟ نعم فرصة جيدة
+
+148
+00:11:37,080 --> 00:11:38,800
+تستطيع أن تأخذ .. تستطيع أن تأخذ الاسبريكس و؟ نعم
+
+149
+00:11:38,800 --> 00:11:38,960
+فرصة جيدة تستطيع أن تأخذ .. تستطيع أن تأخذ
+
+150
+00:11:38,960 --> 00:11:40,660
+الاسبريكس و؟ نعم فرصة جيدة تستطيع أن تأخذ
+
+151
+00:11:40,660 --> 00:11:46,860
+الاسبريكس و؟ نعم فرصة جيدة تستطيع أن
+
+152
+00:11:46,860 --> 00:11:50,680
+تأخذ الاسبريكس و؟ نعم فرصة جيدة تستطيع أن تأخذ
+
+153
+00:11:50,680 --> 00:11:57,880
+الاسبريكس و؟ نعم فرصة جيدة تستطيع أن
+
+154
+00:11:57,880 --> 00:12:01,930
+تأخذ الاسبريكس و؟ نعم فرصة جيدة تستطيع أنyou could
+
+155
+00:12:01,930 --> 00:12:06,070
+have taken the airport bus or maybe a maid could
+
+156
+00:12:06,070 --> 00:12:10,090
+have taken you thank you very much now listen I
+
+157
+00:12:10,090 --> 00:12:15,090
+took a taxi to the airport where are you now?in
+
+158
+00:12:15,090 --> 00:12:19,310
+the airport okay so in the previous situation you
+
+159
+00:12:19,310 --> 00:12:23,110
+were still at home now you are in the airport and
+
+160
+00:12:23,110 --> 00:12:25,930
+it cost me a big amount I paid too much to the
+
+161
+00:12:25,930 --> 00:12:30,730
+taxi now you should have taken the airport bus
+
+162
+00:12:30,730 --> 00:12:34,470
+what what does that express yes mean hindsight
+
+163
+00:12:34,470 --> 00:12:39,130
+advice very good or you could have taken the
+
+164
+00:12:39,130 --> 00:12:43,150
+airport bus this expresses what ندا that's right
+
+165
+00:12:43,150 --> 00:12:44,250
+thank you very much good
+
+166
+00:12:47,920 --> 00:12:53,880
+لنحكي عن الفرازين و الاختصارين، واحدة من الموضوعات
+
+167
+00:12:53,880 --> 00:13:00,040
+المهمة في اللغة الكلمية. منذ أن بدأت تدرس اللغة
+
+168
+00:13:00,040 --> 00:13:05,260
+الكلمية، يجب أن تعرف ما هي الفراز، ما هو الشكل، ما
+
+169
+00:13:05,260 --> 00:13:10,080
+هي الشكلات من الفرازين، ما هي الاختصار و ما هي
+
+170
+00:13:10,080 --> 00:13:14,900
+الشكلات من الاختصارين. لذلك، أرجو الانتظار و
+
+171
+00:13:14,900 --> 00:13:24,490
+لنبدأ.الان عندما أقول في المدرسة، في الشارع، في
+
+172
+00:13:24,490 --> 00:13:35,870
+المنزل، في الشمس الاخرى، هم ماذا؟ هم مجموعات
+
+173
+00:13:35,870 --> 00:13:41,150
+كلمات، صحيح؟ هم مجموعات كلمات عندما أقول على سبيل
+
+174
+00:13:41,150 --> 00:13:46,790
+المثال، تلك الفتاة الصغيرةف this is a group of
+
+175
+00:13:46,790 --> 00:13:51,010
+words. Does it have a verb? No. Does it have a
+
+176
+00:13:51,010 --> 00:13:55,090
+subject? No. Does it have a meaning? No. This is
+
+177
+00:13:55,090 --> 00:14:01,530
+called what?فرسة فماذا هي الفرسة؟ مجموعة من
+
+178
+00:14:01,530 --> 00:14:05,290
+الكلمات التي تجعلها مفهومة عندما أقول طفلة طويلة،
+
+179
+00:14:05,290 --> 00:14:09,550
+هل هي مفهومة؟ هي مفهومة ولكنها ليست مفهومة تمامة
+
+180
+00:14:09,550 --> 00:14:14,830
+ماذا عن الطفلة الطويلة؟ ماذا عنها؟ هل هي طيارة؟ هل
+
+181
+00:14:14,830 --> 00:14:19,810
+هي أختي؟ هل هي أختك؟ هل هي تقولك أي شيء عن ذلك؟ لا
+
+182
+00:14:19,810 --> 00:14:26,350
+يجعلها مفهومة حسنًا، إنها اسمية ماذا؟ فرسةit is a
+
+183
+00:14:26,350 --> 00:14:29,410
+group of related words without a subject and a
+
+184
+00:14:29,410 --> 00:14:35,830
+finite verb when
+
+185
+00:14:35,830 --> 00:14:41,930
+I say for example yesterday's cold weather
+
+186
+00:14:44,630 --> 00:14:49,010
+yesterday's cold weather a group of words okay
+
+187
+00:14:49,010 --> 00:14:52,790
+does it make sense it makes sense but not complete
+
+188
+00:14:52,790 --> 00:14:57,790
+sense does it have a subject or a verb no what is
+
+189
+00:14:57,790 --> 00:15:00,690
+a finite verb where is the verb when i say
+
+190
+00:15:00,690 --> 00:15:04,390
+yesterday's cold weather does it have a verb no
+
+191
+00:15:04,390 --> 00:15:10,030
+verb okay soWhat is a finite verb? Before we
+
+192
+00:15:10,030 --> 00:15:13,310
+start, since a finite verb is mentioned, what is a
+
+193
+00:15:13,310 --> 00:15:17,290
+finite verb? A finite verb must have a tense and
+
+194
+00:15:17,290 --> 00:15:21,830
+agree with its subject in number and person. Now,
+
+195
+00:15:21,890 --> 00:15:26,130
+at the beginning of this course, we studied
+
+196
+00:15:26,130 --> 00:15:32,110
+tenses, right? The present simple, go for example
+
+197
+00:15:36,380 --> 00:15:41,100
+is going has gone will go will be going will have
+
+198
+00:15:41,100 --> 00:15:46,460
+gone okay they all have tenses right these verbs
+
+199
+00:15:46,460 --> 00:15:50,620
+which have tenses and agree with the subject what
+
+200
+00:15:50,620 --> 00:15:52,520
+does it mean agree with the subject who can
+
+201
+00:15:52,520 --> 00:15:58,380
+explain that yeah plural like for example I go he
+
+202
+00:15:58,380 --> 00:16:04,060
+goes okay I go he goes now this is called a finite
+
+203
+00:16:04,060 --> 00:16:09,000
+verb lookIn English there are four non-finite
+
+204
+00:16:09,000 --> 00:16:12,500
+verbs. You know we are not going to talk about
+
+205
+00:16:12,500 --> 00:16:18,620
+finite verbs because you know them. All the verbs,
+
+206
+00:16:18,800 --> 00:16:22,120
+all the tenses that we studied at the beginning of
+
+207
+00:16:22,120 --> 00:16:26,060
+this course are called what؟finite verbs the
+
+208
+00:16:26,060 --> 00:16:29,740
+present simple the past simple the past continuous
+
+209
+00:16:29,740 --> 00:16:32,460
+the present continuous and and and and you know
+
+210
+00:16:32,460 --> 00:16:36,060
+the stories of the tenses right or any verb that
+
+211
+00:16:36,060 --> 00:16:39,940
+has a tense agrees with the subject this is called
+
+212
+00:16:39,940 --> 00:16:44,260
+a finite verb we want to recognize the non-finite
+
+213
+00:16:44,260 --> 00:16:47,960
+verbs what are the non-finite verbs in English you
+
+214
+00:16:47,960 --> 00:16:51,440
+know there are four non-finite verbs what are they
+
+215
+00:16:51,440 --> 00:16:56,020
+the infinitiveالجيران، الـ present participle و
+
+216
+00:16:56,020 --> 00:17:00,800
+الـ past participle هما يسمون كيف؟ نانفينيات كلمة،
+
+217
+00:17:00,800 --> 00:17:04,720
+هما نانفينيات كلمة، على سبيل المثال، لأكل، هل
+
+218
+00:17:04,720 --> 00:17:13,200
+لديها قصة؟ لا، هذا نانفينيات كلمة، لأكل، مستمر
+
+219
+00:17:13,200 --> 00:17:20,340
+مستمر، هذا نانفينيات كلمة، لأكل، هذا نانفينيات
+
+220
+00:17:20,340 --> 00:17:28,340
+كلمةالان جيران يأكلون ويأكلون هم جيران، هذا جيران
+
+221
+00:17:28,340 --> 00:17:32,600
+بسيط وهذا جيران ممتاز، هم لعبة، حسنا؟ ليس لعبات
+
+222
+00:17:32,600 --> 00:17:38,860
+محددة ومشاركات الحجر، يأكلون، يلعبون، انتظر، هل
+
+223
+00:17:38,860 --> 00:17:44,240
+يأكل؟ هذه لعبة محددة، هم يأكلون، نحن نأكلون، أنت
+
+224
+00:17:44,240 --> 00:17:48,680
+تأكلون، أنا أأكلون، لعبات محددة، لكن يأكلون وحسب
+
+225
+00:17:49,570 --> 00:17:55,130
+eating alone a part of the present progressive it
+
+226
+00:17:55,130 --> 00:18:01,690
+is a non-finite and eaten go went gone seen saw
+
+227
+00:18:01,690 --> 00:18:07,510
+seen seen is it a verb yes does it have a tense no
+
+228
+00:18:07,510 --> 00:18:13,850
+have seenhas a tense right had seen has a tense
+
+229
+00:18:13,850 --> 00:18:18,390
+but seen alone doesn't have a tense so this is
+
+230
+00:18:18,390 --> 00:18:23,550
+called an infinite verb is that clear yes any
+
+231
+00:18:23,550 --> 00:18:29,050
+questionSo they are all called what? Non-finite
+
+232
+00:18:29,050 --> 00:18:31,530
+verbs And what is a finite verb? Can you give me
+
+233
+00:18:31,530 --> 00:18:34,910
+an example of a finite verb? Who can give me an
+
+234
+00:18:34,910 --> 00:18:40,210
+example? Yes please Give me an example When؟ Good
+
+235
+00:18:40,210 --> 00:18:49,010
+thank you I went to school For example Okay I eat
+
+236
+00:18:49,010 --> 00:18:53,160
+my breakfast at home thank youhe is playing thank
+
+237
+00:18:53,160 --> 00:18:59,940
+you very much go on now listen now
+
+238
+00:18:59,940 --> 00:19:02,940
+words or a group of words in italics are phrases
+
+239
+00:19:02,940 --> 00:19:07,640
+in the examples below number one number one read
+
+240
+00:19:07,640 --> 00:19:14,020
+it the sun rises in the east in the east this is a
+
+241
+00:19:14,020 --> 00:19:20,340
+group of word does it have a verbالأن في الشمس
+
+242
+00:19:20,340 --> 00:19:24,720
+تجعلها مفهومة لكن ليست مفهومة تمامة هذا يسمى كيف؟
+
+243
+00:19:24,720 --> 00:19:35,600
+فرصة، فرصة، حسنًا، رقم اتنين ماذا
+
+244
+00:19:35,600 --> 00:19:41,240
+عن هذه الاسم؟ ماذا ستقول عن هذه الاسم؟ فرصة، فرصة،
+
+245
+00:19:41,240 --> 00:19:41,720
+لأن
+
+246
+00:20:04,980 --> 00:20:06,380
+فضلي
+
+247
+00:20:16,530 --> 00:20:23,050
+yes you okay
+
+248
+00:20:23,050 --> 00:20:28,450
+it is a phrase because okay
+
+249
+00:20:28,450 --> 00:20:38,150
+it doesn't have a verb thank you next one artist
+
+250
+00:20:38,150 --> 00:20:42,670
+with the red hair with the red hair this is what a
+
+251
+00:20:42,670 --> 00:20:51,310
+phrase becauseOkay thank you next one thank
+
+252
+00:20:51,310 --> 00:20:55,830
+you
+
+253
+00:20:55,830 --> 00:21:01,030
+very much and finally finally yes please holding
+
+254
+00:21:01,030 --> 00:21:08,070
+the toy yeah okay
+
+255
+00:21:08,070 --> 00:21:11,490
+this is a phrase holding the toy it doesn't have
+
+256
+00:21:12,240 --> 00:21:19,260
+أفينية كلمة حسنا جيد الآن مصطلحات الفرصة الآن
+
+257
+00:21:19,260 --> 00:21:22,640
+جميعكم تعرفون ما هي الفرصة صحيح؟ من يقدر يعطيني
+
+258
+00:21:22,640 --> 00:21:34,680
+فرصة؟ اعطني فرصة من نفسك حسنا و شكرا جميل و شكرا
+
+259
+00:21:34,680 --> 00:21:39,360
+جزيلا الآن انظر ما هي المصطلحات؟ حسنا ماذا عنها؟
+
+260
+00:21:39,360 --> 00:21:40,600
+هل تريد أن تقول شيء؟
+
+261
+00:21:43,480 --> 00:21:47,980
+أه yes you want to say something if you want to
+
+262
+00:21:47,980 --> 00:21:52,480
+say something say it aloud so we want one speaker
+
+263
+00:21:52,480 --> 00:21:56,500
+please we agreed that we want one speaker right if
+
+264
+00:21:56,500 --> 00:22:00,300
+you want to say something you are welcome say it
+
+265
+00:22:00,300 --> 00:22:03,420
+so if you don't have listen
+
+266
+00:22:07,770 --> 00:22:11,250
+adjective phrases now before we go to the
+
+267
+00:22:11,250 --> 00:22:14,470
+adjective phrases in general what does the
+
+268
+00:22:14,470 --> 00:22:21,430
+adjective do when I say a cold weather when I say
+
+269
+00:22:21,430 --> 00:22:27,070
+weather okay weather what type of weather now what
+
+270
+00:22:27,070 --> 00:22:32,310
+type of weather do I know I don't knowwhen I say a
+
+271
+00:22:32,310 --> 00:22:38,590
+cold weather cold is an adjective it describes the
+
+272
+00:22:38,590 --> 00:22:41,450
+noun it describes the noun so what does the
+
+273
+00:22:41,450 --> 00:22:45,450
+adjective do it describes the noun the adjective
+
+274
+00:22:45,450 --> 00:22:51,230
+describes the noun the manager the manager what
+
+275
+00:22:51,230 --> 00:22:57,030
+type of manager I don't know was of a great wealth
+
+276
+00:22:57,030 --> 00:23:03,220
+now what do you know about the managerسماهر ماذا
+
+277
+00:23:03,220 --> 00:23:07,800
+تعرف عن الراجل؟ هو لديه .. هو لديه كمية عظيمة ،
+
+278
+00:23:07,800 --> 00:23:13,440
+كمية عظيمة ، والآن هذا .. هذه الكلمة لكمية كمية
+
+279
+00:23:13,440 --> 00:23:19,300
+عظيمة ، هذه .. هذه الفرصة تسمح بالراجل ، الكلمة ،
+
+280
+00:23:19,300 --> 00:23:25,820
+صحيح؟ لذلك فإنها تعمل عمل الاسم ، حسنًا؟ الآن إذا
+
+281
+00:23:25,820 --> 00:23:31,970
+كنت أقول أن الراجل قديمthe manager was old right
+
+282
+00:23:31,970 --> 00:23:36,810
+old describes what the manager instead of old
+
+283
+00:23:36,810 --> 00:23:39,910
+instead of the adjective i used what or the
+
+284
+00:23:39,910 --> 00:23:43,730
+manager the manager was wealthy for example the
+
+285
+00:23:43,730 --> 00:23:47,830
+manager was rich the manager was rich rich
+
+286
+00:23:47,830 --> 00:23:51,990
+describes what the manager instead of rich of one
+
+287
+00:23:51,990 --> 00:23:56,260
+word i used a phrase of a great wealthso this
+
+288
+00:23:56,260 --> 00:23:59,680
+phrase which describes the noun it's called
+
+289
+00:23:59,680 --> 00:24:04,580
+adjective phrase okay good next one please he
+
+290
+00:24:04,580 --> 00:24:12,440
+lives okay a house what type of house I don't know
+
+291
+00:24:12,440 --> 00:24:16,960
+what type of house I don't know now built of stone
+
+292
+00:24:16,960 --> 00:24:22,820
+built of stone yes go on now built of stone
+
+293
+00:24:22,820 --> 00:24:31,110
+describesthe house this is what this is a phrase
+
+294
+00:24:31,110 --> 00:24:36,810
+but it has a verb please one speaker built is a
+
+295
+00:24:36,810 --> 00:24:43,630
+verb right so how how do we call it a phrase built
+
+296
+00:24:43,630 --> 00:24:50,530
+yes built it is a verbI'm talking about built we
+
+297
+00:24:50,530 --> 00:24:54,570
+said a phrase what is a phrase a group of words
+
+298
+00:24:54,570 --> 00:24:58,510
+without a
+
+299
+00:24:58,510 --> 00:25:02,850
+finite verb right so what about built past
+
+300
+00:25:02,850 --> 00:25:09,070
+participle is it a finite verb it is a verb but it
+
+301
+00:25:09,070 --> 00:25:12,930
+is a non-finite verb okay it is a verb but it is a
+
+302
+00:25:12,930 --> 00:25:18,290
+non-finite verb soit is و this is a phrase this
+
+303
+00:25:18,290 --> 00:25:27,690
+phrase describes the noun so it is good now yes
+
+304
+00:25:27,690 --> 00:25:31,370
+please I like to see a face with a smile on it
+
+305
+00:25:31,370 --> 00:25:34,250
+okay do you like to see a face with a smile on it
+
+306
+00:25:34,250 --> 00:25:37,150
+yes so look at your colleague look at each other
+
+307
+00:25:38,330 --> 00:25:42,270
+Okay I like to say .. to see a face with a smile
+
+308
+00:25:42,270 --> 00:25:45,230
+on it with a smile on it what would you say about
+
+309
+00:25:45,230 --> 00:25:52,770
+this group of words? okay what type of face? what
+
+310
+00:25:52,770 --> 00:25:56,070
+type of face I don't know now this describes the
+
+311
+00:25:56,070 --> 00:25:59,830
+noun so what is the adjective phrase? who can tell
+
+312
+00:25:59,830 --> 00:26:04,790
+me? yes okay
+
+313
+00:26:04,790 --> 00:26:09,720
+thank you very muchit is the phrase that describes
+
+314
+00:26:09,720 --> 00:26:13,080
+the noun the phrase that does the work of the
+
+315
+00:26:13,080 --> 00:26:16,480
+adjective right what does the adjective do it
+
+316
+00:26:16,480 --> 00:26:20,640
+describes the noun it modifies the noun okay so
+
+317
+00:26:20,640 --> 00:26:23,600
+the phrase which modifies which describes the noun
+
+318
+00:26:23,600 --> 00:26:27,500
+is called an adjective phrase so read this
+
+319
+00:26:27,500 --> 00:26:33,560
+definition yes سهرeach group of underlined words
+
+320
+00:26:33,560 --> 00:26:38,360
+qualifies a noun just and as an adjective does it
+
+321
+00:26:38,360 --> 00:26:42,160
+therefore does the work of an adjective and is
+
+322
+00:26:42,160 --> 00:26:46,620
+called an adjective okay thank you very much now
+
+323
+00:26:46,620 --> 00:26:50,260
+each group of underlined words why did you omit
+
+324
+00:26:50,260 --> 00:26:57,040
+that do you think that is not necessary here what
+
+325
+00:26:57,040 --> 00:27:00,910
+do you knowthat is it necessary she deleted she
+
+326
+00:27:00,910 --> 00:27:05,710
+omitted it is it necessary or not and why yes it's
+
+327
+00:27:05,710 --> 00:27:07,630
+necessary because the speaker and the listener
+
+328
+00:27:07,630 --> 00:27:10,390
+know what the word is that's right is it a
+
+329
+00:27:10,390 --> 00:27:14,610
+definite or a generic noun words okay we are
+
+330
+00:27:14,610 --> 00:27:18,090
+talking about specific groups of words right thank
+
+331
+00:27:18,090 --> 00:27:21,170
+you very much now again you know what is the
+
+332
+00:27:21,170 --> 00:27:24,230
+adjective phrase now right any question on this
+
+333
+00:27:24,230 --> 00:27:24,710
+point
+
+334
+00:27:27,370 --> 00:27:30,870
+Now let's have an exercise, let's have an
+
+335
+00:27:30,870 --> 00:27:36,230
+exercise, look at this exercise, pick out the
+
+336
+00:27:36,230 --> 00:27:38,850
+adjective phrases in the following sentences,
+
+337
+00:27:39,490 --> 00:27:43,330
+okay, you have two minutes, it will be enough, do
+
+338
+00:27:43,330 --> 00:27:46,870
+the exercise all of you please, all of you do the
+
+339
+00:27:46,870 --> 00:27:47,570
+exercise
+
+340
+00:28:21,360 --> 00:28:26,500
+الان دعونا نتكلم و نتحقق الإجابة دعونا نتحدث رقم
+
+341
+00:28:26,500 --> 00:28:37,190
+واحد رقم واحد نعم أرجوك هنالما لما لما
+
+342
+00:28:37,190 --> 00:28:41,850
+لما
+
+343
+00:28:41,850 --> 00:28:45,470
+لما لما لما لما لما لما لما لما لما لما لما لما
+
+344
+00:28:45,470 --> 00:28:46,050
+لما لما لما لما لما لما لما لما لما لما لما لما
+
+345
+00:28:46,050 --> 00:28:49,810
+لما لما لما لما لما لما لما لما لما لما لما لما
+
+346
+00:28:49,810 --> 00:28:50,910
+لما لما لما لما لما لما لما لما لما لما لما لما
+
+347
+00:28:50,910 --> 00:28:50,910
+لما لما لما لما لما لما لما لما لما لما لما لما
+
+348
+00:28:50,910 --> 00:28:52,570
+لما لما لما لما لما لما لما لما لما لما لما لما
+
+349
+00:28:52,570 --> 00:28:53,570
+لما لما لما لما لما لما لما لما لما لما لما لما
+
+350
+00:28:53,570 --> 00:28:54,110
+لما لما لما لما لما لما لما لما لما لما لما لما
+
+351
+00:28:54,110 --> 00:28:56,310
+لما لما لما لما لما لما لما لما لما لما لما لما
+
+352
+00:28:56,760 --> 00:29:02,920
+Okay look look this a very long group of words
+
+353
+00:29:02,920 --> 00:29:06,980
+does it have a verb no thank you it is a phrase
+
+354
+00:29:06,980 --> 00:29:10,500
+yes what about this group yes this group next one
+
+355
+00:29:10,500 --> 00:29:17,460
+number three فضلي go on yeah a friend what type of
+
+356
+00:29:17,460 --> 00:29:20,820
+friend which friend okay in need thank you very
+
+357
+00:29:20,820 --> 00:29:25,200
+much next one yes please new ones new ones yes
+
+358
+00:29:25,200 --> 00:29:25,880
+please there
+
+359
+00:29:29,340 --> 00:29:34,020
+a stitch in time saves
+
+360
+00:29:34,020 --> 00:29:42,480
+nine a stitch in time saves nine your friend where
+
+361
+00:29:42,480 --> 00:29:46,420
+is the phrase which
+
+362
+00:29:46,420 --> 00:29:52,240
+stitch in time okay in time this is a good saying
+
+363
+00:29:52,240 --> 00:29:58,940
+a good proverb okay yeah next onea bird in the
+
+364
+00:29:58,940 --> 00:30:03,500
+hand is worth two in the pot good thank you how
+
+365
+00:30:03,500 --> 00:30:06,600
+many phrases do you have two phrases okay good
+
+366
+00:30:06,600 --> 00:30:10,320
+thank you very much yeah I couldn't really accept
+
+367
+00:30:10,320 --> 00:30:15,880
+is a friend indeed a phrase again is a friend
+
+368
+00:30:15,880 --> 00:30:18,360
+indeed isn't a phrase
+
+369
+00:30:22,770 --> 00:30:26,570
+we said a phrase usually is a group of words okay
+
+370
+00:30:26,570 --> 00:30:33,010
+usually it is a group of words not one word though
+
+371
+00:30:33,010 --> 00:30:40,350
+some books consider it okay a phrase now let's
+
+372
+00:30:40,350 --> 00:30:47,520
+come to the adverb what does the adverb do yesit
+
+373
+00:30:47,520 --> 00:30:56,280
+describes the verb he ran quickly right it rained
+
+374
+00:30:56,280 --> 00:31:02,140
+heavily okay it describes the word the verb she
+
+375
+00:31:02,140 --> 00:31:07,660
+ran with a great speed with how did she runwith a
+
+376
+00:31:07,660 --> 00:31:17,300
+great speed with a
+
+377
+00:31:17,300 --> 00:31:22,980
+great speed with a great speed with
+
+378
+00:31:22,980 --> 00:31:28,120
+a
+
+379
+00:31:28,120 --> 00:31:28,600
+great speed with a great speed with a great speed
+
+380
+00:31:28,600 --> 00:31:29,420
+with a great speed with a great speed with a great
+
+381
+00:31:29,420 --> 00:31:29,560
+speed with a great speed with a great speed with a
+
+382
+00:31:29,560 --> 00:31:29,620
+great speed with a great speed with a great speed
+
+383
+00:31:29,620 --> 00:31:29,620
+with a great speed with a great speed with a great
+
+384
+00:31:29,620 --> 00:31:29,620
+speed with a great speed with a great speed with a
+
+385
+00:31:29,620 --> 00:31:29,620
+great speed with a great speed with a great speed
+
+386
+00:31:29,620 --> 00:31:29,620
+with a great speed with a great speed with a great
+
+387
+00:31:29,620 --> 00:31:29,620
+speed with a great speed with a great speed with a
+
+388
+00:31:29,620 --> 00:31:30,440
+great speed with a great speed with a great speed
+
+389
+00:31:30,440 --> 00:31:31,580
+with a great speed with a great speed with a great
+
+390
+00:31:31,580 --> 00:31:31,640
+speed with a great speed with a great speed with a
+
+391
+00:31:31,640 --> 00:31:31,700
+great speed with a great speed with a great speed
+
+392
+00:31:31,700 --> 00:31:32,140
+with a great speed with a great speed with a great
+
+393
+00:31:32,140 --> 00:31:32,340
+speed with a great speed with a great speed with a
+
+394
+00:31:32,340 --> 00:31:32,340
+great speed with a great speed with a great speed
+
+395
+00:31:32,340 --> 00:31:32,340
+with a great speed with a great speed with a great
+
+396
+00:31:32,340 --> 00:31:32,340
+speed with a great speed with a great speed with a
+
+397
+00:31:32,340 --> 00:31:32,340
+great speed with a great speed with a great speed
+
+398
+00:31:32,340 --> 00:31:37,180
+with a great speed with a great speedwhat is the
+
+399
+00:31:37,180 --> 00:31:42,560
+adverb phrase؟ it is the phrase which describes
+
+400
+00:31:42,560 --> 00:31:47,020
+the verb which does the work of the adverb right
+
+401
+00:31:47,020 --> 00:31:50,240
+which does the work of the adverb read please the
+
+402
+00:31:50,240 --> 00:31:52,980
+definition each group of the underlying verbs
+
+403
+00:31:52,980 --> 00:31:56,760
+qualifies a verb just as an adverb does it's
+
+404
+00:31:56,760 --> 00:31:59,840
+therefore that the work of an adverb is understood
+
+405
+00:31:59,840 --> 00:32:05,110
+as an adverb phrase thank youالان هذا مجرد مجرد
+
+406
+00:32:05,110 --> 00:32:08,990
+مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد مجرد
+
+407
+00:32:08,990 --> 00:32:25,330
+مجرد مجرد مجرد
+
+408
+00:32:50,170 --> 00:32:54,550
+Okay yes number one I lived in the middle of a
+
+409
+00:32:54,550 --> 00:33:02,760
+grave thank you they lived where?they lived where
+
+410
+00:33:02,760 --> 00:33:07,000
+look this group of words okay describes the where
+
+411
+00:33:07,000 --> 00:33:13,660
+where thank you yes please next one thank
+
+412
+00:33:13,660 --> 00:33:17,960
+you
+
+413
+00:33:17,960 --> 00:33:21,340
+very much thank you very much next one coming to
+
+414
+00:33:21,340 --> 00:33:25,920
+the garden into the garden presents adverb
+
+415
+00:33:25,920 --> 00:33:37,380
+presentsthank you number four yes please لما thank
+
+416
+00:33:37,380 --> 00:33:45,860
+you and finally okay
+
+417
+00:33:45,860 --> 00:33:49,700
+it is an adverb phrase it describes the verb thank
+
+418
+00:33:49,700 --> 00:33:53,700
+you very much for today and see you on wednesday
+
+419
+00:33:53,700 --> 00:33:54,200
+inshallah
+
diff --git a/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/yEZDTDLfB8M_postprocess.srt b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/yEZDTDLfB8M_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..ac25776210ba3a78aa97a1ba3eeef3feaf7623c9
--- /dev/null
+++ b/SKIP:::PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/yEZDTDLfB8M_postprocess.srt
@@ -0,0 +1,1944 @@
+1
+00:00:41,590 --> 00:00:45,230
+إذا أردت أن تفعل شيء
+
+2
+00:00:49,730 --> 00:00:55,290
+أريدك أن تفتح الباب كيف يمكنني أن أقول ذلك؟ يمكنني
+
+3
+00:00:55,290 --> 00:01:03,890
+أن أقول فتح الباب فتح الباب هل
+
+4
+00:01:03,890 --> 00:01:12,290
+يمكنك أن تفتح الباب؟ هل ستفتح الباب؟ هل يمكنك أن
+
+5
+00:01:12,290 --> 00:01:18,570
+تفتح الباب؟ يجب أن تفتح الباب، يجب أن تفتح الباب
+
+6
+00:01:19,940 --> 00:01:25,580
+what do you think of the sentences when I say when
+
+7
+00:01:25,580 --> 00:01:29,160
+I say
+
+8
+00:01:29,160 --> 00:01:33,040
+open
+
+9
+00:01:33,040 --> 00:01:45,320
+the door you
+
+10
+00:01:45,320 --> 00:01:47,300
+should
+
+11
+00:01:49,280 --> 00:01:55,500
+open the door you
+
+12
+00:01:55,500 --> 00:02:07,280
+must you can you should you have to you may now
+
+13
+00:02:07,280 --> 00:02:11,620
+what do you think of the sentences thank you thank
+
+14
+00:02:11,620 --> 00:02:15,580
+youالان ماذا تفكر في الاسلحة؟ عندما أقول لك ..
+
+15
+00:02:15,580 --> 00:02:19,160
+الان هل تريد هذه الشكلة من السلسلة عندما أقول لك
+
+16
+00:02:19,160 --> 00:02:23,260
+افتح الباب؟ فماذا تفكر في هذه السلسلة؟ انها امرأة
+
+17
+00:02:23,260 --> 00:02:26,800
+.. انها امرأة، نعم؟ انها في المدرسة، ربما؟ الناس
+
+18
+00:02:26,800 --> 00:02:29,840
+لا تقبل الأمراد، حسنا؟ انها أفضل جدا أن تكونوا
+
+19
+00:02:29,840 --> 00:02:33,480
+أصدقاء مع الناس، صحيح؟ يجب أن تكونوا أصدقاء، يجب
+
+20
+00:02:33,480 --> 00:02:36,880
+أن تكونوا شخصيين مع الناس، فكيف يمكنني أن أكون
+
+21
+00:02:36,880 --> 00:02:41,160
+شخصي؟ كيف يمكنني أن أتعامل الشخصية مع الناس؟ شكرا،
+
+22
+00:02:41,160 --> 00:02:46,240
+أجل؟very good can you open the door look it is
+
+23
+00:02:46,240 --> 00:02:50,040
+more polite thank you shall you open the door
+
+24
+00:02:50,040 --> 00:02:54,160
+thank you very much good yeah would you please
+
+25
+00:02:54,160 --> 00:02:59,860
+open the door thank you good may you are okay open
+
+26
+00:02:59,860 --> 00:03:03,920
+the door thank you very much thank you or may I
+
+27
+00:03:03,920 --> 00:03:08,380
+have the door opened yes again you should open the
+
+28
+00:03:08,380 --> 00:03:12,640
+door now look okay should is repeated okay now
+
+29
+00:03:15,090 --> 00:03:20,430
+you should you must you can you have to now
+
+30
+00:03:20,430 --> 00:03:26,170
+different forms different ways okay these verbs in
+
+31
+00:03:26,170 --> 00:03:31,130
+English are called what modal verbs good why did
+
+32
+00:03:31,130 --> 00:03:36,450
+we use them now which is better to say you must
+
+33
+00:03:36,450 --> 00:03:42,290
+open the door or you could open the dooryou could
+
+34
+00:03:42,290 --> 00:03:46,250
+okay it is more polite very good it is more polite
+
+35
+00:03:46,250 --> 00:03:50,990
+so modal verbs are used in English to express what
+
+36
+00:03:50,990 --> 00:03:54,870
+attitudes to express attitudes you want to be
+
+37
+00:03:54,870 --> 00:03:58,950
+polite with some people more polite with other
+
+38
+00:03:58,950 --> 00:04:03,010
+people less polite with other people formal with
+
+39
+00:04:03,010 --> 00:04:06,570
+some people informal with your friends and so on
+
+40
+00:04:06,570 --> 00:04:11,200
+that's right we use modal verbs modal verbsexpress
+
+41
+00:04:11,200 --> 00:04:15,600
+attitudes they are very necessary in communication
+
+42
+00:04:15,600 --> 00:04:22,060
+so you have to be careful when using them okay you
+
+43
+00:04:22,060 --> 00:04:25,900
+should be polite with some people or you should be
+
+44
+00:04:25,900 --> 00:04:29,000
+more polite with some people than others right
+
+45
+00:04:29,000 --> 00:04:32,900
+that's why we use the right modal verb
+
+46
+00:04:43,350 --> 00:04:48,310
+let's begin by this exercise correct
+
+47
+00:04:48,310 --> 00:04:52,490
+the errors in the verb forms correct the errors in
+
+48
+00:04:52,490 --> 00:04:58,630
+the verb forms yes she can see it
+
+49
+00:04:58,630 --> 00:05:03,430
+thank you okay she can see it thank you yes الدعاء
+
+50
+00:05:03,730 --> 00:05:08,550
+she can .. she can to see it drop the two okay so
+
+51
+00:05:08,550 --> 00:05:12,750
+she can see it good thank you yes Najwa she can
+
+52
+00:05:12,750 --> 00:05:16,610
+see it without s without s very good thank you yes
+
+53
+00:05:16,610 --> 00:05:20,610
+please she can see it drop s drop s thank you very
+
+54
+00:05:20,610 --> 00:05:25,490
+much thank you good yes again can you pass the
+
+55
+00:05:25,490 --> 00:05:32,370
+last place so can you pass the last place so can
+
+56
+00:05:32,370 --> 00:05:36,380
+you which endOkay that's right thank you very much
+
+57
+00:05:36,380 --> 00:05:43,820
+good yes please yeah okay
+
+58
+00:05:43,820 --> 00:05:50,140
+can you see it that's right so we say can you see
+
+59
+00:05:50,140 --> 00:05:54,460
+it can you see it thank you this should come here
+
+60
+00:05:54,460 --> 00:06:00,120
+okay good again so
+
+61
+00:06:00,120 --> 00:06:08,600
+againthey can't they can't go there thank you good
+
+62
+00:06:08,600 --> 00:06:15,580
+yes please to pay thank you very much to pay now
+
+63
+00:06:15,580 --> 00:06:24,860
+can okay is a modal verb right yes now what do you
+
+64
+00:06:24,860 --> 00:06:30,010
+understand from this exercisemodels have special
+
+65
+00:06:30,010 --> 00:06:34,050
+nature okay they behave in a certain way in
+
+66
+00:06:34,050 --> 00:06:37,530
+grammar they have certain grammatical behaviors
+
+67
+00:06:37,530 --> 00:06:42,210
+right they accept some things and they reject
+
+68
+00:06:42,210 --> 00:06:45,670
+don't accept refuse other things what would you
+
+69
+00:06:45,670 --> 00:06:49,450
+say now from this exercise what do you understand
+
+70
+00:06:49,450 --> 00:06:56,390
+yes please model verbs should developvery good now
+
+71
+00:06:56,390 --> 00:07:00,850
+modal verbs should be followed by okay we say bear
+
+72
+00:07:00,850 --> 00:07:06,850
+infinitive bear infinitive what is the bear
+
+73
+00:07:06,850 --> 00:07:13,190
+infinitive it is the base form can you give me an
+
+74
+00:07:13,190 --> 00:07:19,690
+exampleyeah eat right play sleep clean okay they
+
+75
+00:07:19,690 --> 00:07:23,530
+are base forms they are bare infinitives okay so
+
+76
+00:07:23,530 --> 00:07:30,210
+you should say you can go he can go she can go now
+
+77
+00:07:30,210 --> 00:07:35,730
+she goes she goes but she can go she should go he
+
+78
+00:07:35,730 --> 00:07:42,360
+must goOkay now they she can see she can see they
+
+79
+00:07:42,360 --> 00:07:44,960
+should be followed by a bare infinitive good this
+
+80
+00:07:44,960 --> 00:07:49,310
+is one point another point yes pleaseyeah what do
+
+81
+00:07:49,310 --> 00:07:55,890
+you understand فضلي very
+
+82
+00:07:55,890 --> 00:07:59,190
+good
+
+83
+00:07:59,190 --> 00:08:03,830
+they don't accept the final s okay you know she
+
+84
+00:08:03,830 --> 00:08:08,670
+can he can i can so this final s should be dropped
+
+85
+00:08:09,460 --> 00:08:13,420
+will can could may might they don't accept the
+
+86
+00:08:13,420 --> 00:08:18,460
+final s but the other verbs the lexical verbs the
+
+87
+00:08:18,460 --> 00:08:21,920
+other verbs go play can they are called what
+
+88
+00:08:21,920 --> 00:08:28,200
+lexical verbs okay now lexical yeah lexical verbs
+
+89
+00:08:28,200 --> 00:08:32,660
+they give us meaning like go sleep come write
+
+90
+00:08:32,660 --> 00:08:39,810
+drink cleanwe say I go she goes I play he plays
+
+91
+00:08:39,810 --> 00:08:44,750
+and so on but I can he can it is the same form so
+
+92
+00:08:44,750 --> 00:08:49,950
+again modal verbs don't accept this good yes what
+
+93
+00:08:49,950 --> 00:08:51,110
+else yes please
+
+94
+00:08:57,030 --> 00:09:04,290
+Okay so we should have a verb subject order we
+
+95
+00:09:04,290 --> 00:09:08,070
+have we should start with the verb then the
+
+96
+00:09:08,070 --> 00:09:10,970
+subject okay with the model thank you very much
+
+97
+00:09:10,970 --> 00:09:13,630
+now what about this point you did not comment on
+
+98
+00:09:13,630 --> 00:09:15,450
+number two yes please
+
+99
+00:09:21,330 --> 00:09:24,150
+very good thank you very much they are not
+
+100
+00:09:24,150 --> 00:09:29,630
+followed by two you must go you can go don't say
+
+101
+00:09:29,630 --> 00:09:35,090
+you must go okay don't say you should to go with
+
+102
+00:09:35,090 --> 00:09:43,870
+but ought to only and you know and what able to
+
+103
+00:09:43,870 --> 00:09:48,720
+okay they are something else they have okayالان
+
+104
+00:09:48,720 --> 00:09:53,220
+نحن نتحدث عن مدالات نحن سنتحدث عن able to فقط
+
+105
+00:09:53,220 --> 00:09:57,420
+انتظر ارجاء الان ماذا عن .. ماذا تفهمه من هذا
+
+106
+00:09:57,420 --> 00:10:03,180
+النقطة؟ رقم 6 رقم 6 نعم
+
+107
+00:10:06,030 --> 00:10:09,990
+yes don't use verb to do so if you use a modal
+
+108
+00:10:09,990 --> 00:10:13,410
+verb we don't know we don't need the do support
+
+109
+00:10:13,410 --> 00:10:17,910
+okay this is in grammar called do support I need
+
+110
+00:10:17,910 --> 00:10:20,850
+do thus did to help me to make questions for
+
+111
+00:10:20,850 --> 00:10:25,450
+example but if I have any modal will you should
+
+112
+00:10:25,450 --> 00:10:30,740
+you okay can youand so on we don't use the do
+
+113
+00:10:30,740 --> 00:10:35,120
+support no need for the verb to do that's right
+
+114
+00:10:35,120 --> 00:10:38,360
+thank you and next one when we make a negative
+
+115
+00:10:38,360 --> 00:10:45,300
+statement we added the not with can just very good
+
+116
+00:10:45,300 --> 00:10:48,640
+so they accept the not we said they don't accept
+
+117
+00:10:48,640 --> 00:10:53,680
+the final s but they accept what the not okay so
+
+118
+00:10:53,680 --> 00:10:58,490
+they accept the not and finallyand finally what do
+
+119
+00:10:58,490 --> 00:11:04,270
+you understand from this one yes please okay thank
+
+120
+00:11:04,270 --> 00:11:06,850
+you very much thank you very much now what can you
+
+121
+00:11:06,850 --> 00:11:09,970
+say about models tell me what can you say about
+
+122
+00:11:09,970 --> 00:11:16,770
+models we use models to express attitudes in
+
+123
+00:11:16,770 --> 00:11:22,290
+general okay attitudes good politeness okay advice
+
+124
+00:11:22,290 --> 00:11:28,330
+request and so on thank you andability good that's
+
+125
+00:11:28,330 --> 00:11:31,190
+right that's right thank you very much now what
+
+126
+00:11:31,190 --> 00:11:35,730
+about grammar how do advice how do they behave in
+
+127
+00:11:35,730 --> 00:11:42,930
+grammar in grammar yeah okay
+
+128
+00:11:42,930 --> 00:11:46,130
+should be followed by a base form or bare
+
+129
+00:11:46,130 --> 00:11:49,630
+infinitive okay bare infinitive you know some
+
+130
+00:11:49,630 --> 00:11:54,600
+booksthis is the infinitive to see it is called
+
+131
+00:11:54,600 --> 00:11:57,460
+infinitive in sandbox okay this is called
+
+132
+00:11:57,460 --> 00:12:01,640
+infinitive to see to eat to go to come but let's
+
+133
+00:12:01,640 --> 00:12:05,400
+be more accurate and say bare infinitive without
+
+134
+00:12:05,400 --> 00:12:09,800
+any addition okay base form it is the base form go
+
+135
+00:12:09,800 --> 00:12:13,760
+right come play okay so they should be followed by
+
+136
+00:12:13,760 --> 00:12:18,970
+the bare infinitive by the base formand they don't
+
+137
+00:12:18,970 --> 00:12:23,290
+model don't take final s okay they don't accept
+
+138
+00:12:23,290 --> 00:12:27,030
+final s but they accept what not thank you good
+
+139
+00:12:27,030 --> 00:12:32,030
+and yes again that's
+
+140
+00:12:32,030 --> 00:12:34,910
+right any questions we start with the verb then
+
+141
+00:12:34,910 --> 00:12:38,610
+with the subject okay will you can you and so on
+
+142
+00:12:38,610 --> 00:12:43,990
+yeahit doesn't accept s but it accepts نه thank
+
+143
+00:12:43,990 --> 00:12:50,150
+you good and yeah should be followed by two that's
+
+144
+00:12:50,150 --> 00:12:55,710
+right thank you okay
+
+145
+00:12:55,710 --> 00:12:58,190
+thank you now
+
+146
+00:13:11,490 --> 00:13:15,630
+as we said okay yes read the introduction please
+
+147
+00:13:21,620 --> 00:13:27,060
+attitude يعني تتعامل مع نفسك تتعامل مع نفسك تتعامل
+
+148
+00:13:27,060 --> 00:13:30,680
+مع نفسك تتعامل مع نفسك تتعامل مع نفسك تتعامل مع
+
+149
+00:13:30,680 --> 00:13:34,120
+نفسك تتعامل مع نفسك تتعامل مع نفسك تتعامل مع نفسك
+
+150
+00:13:34,120 --> 00:13:34,600
+تتعامل مع نفسك تتعامل مع نفسك تتعامل مع نفسك
+
+151
+00:13:34,600 --> 00:13:37,300
+تتعامل مع نفسك تتعامل مع نفسك تتعامل مع نفسك
+
+152
+00:13:37,300 --> 00:13:38,520
+تتعامل مع نفسك تتعامل مع نفسك تتعامل مع نفسك
+
+153
+00:13:38,520 --> 00:13:41,580
+تتعامل مع نفسك تتعامل مع نفسك تتعامل مع نفسك
+
+154
+00:13:54,370 --> 00:14:02,110
+الان يستطيعون ان يوضعوا قوة هذه القصص الان استمعوا
+
+155
+00:14:02,110 --> 00:14:08,630
+يجب ان تأتيوا بسرعه يجب ان تأتيوا بسرعه هم نفس
+
+156
+00:14:08,630 --> 00:14:18,010
+الناسلا، حسنا، يجب أن تأتي بسرعة، يعني هم يظهرون
+
+157
+00:14:18,010 --> 00:14:22,790
+قوة هذه الهجومات، وانت تعرفين الواضحة، في بعض
+
+158
+00:14:22,790 --> 00:14:26,170
+الأحيان يجب أن تكون، على سبيل المثال، واضح مع بعض
+
+159
+00:14:26,170 --> 00:14:29,610
+الناس، مع أشخاص أخرين يجب أن تكونوا أكثر واضحين
+
+160
+00:14:30,000 --> 00:14:33,420
+Okay. So you use words to express the first
+
+161
+00:14:33,420 --> 00:14:36,180
+situation, the first attitude and words to express
+
+162
+00:14:36,180 --> 00:14:39,720
+the other attitude. Thank you very much. Now, this
+
+163
+00:14:39,720 --> 00:14:43,060
+is important. Each model has more than one meaning
+
+164
+00:14:43,060 --> 00:14:46,480
+or use. Okay. This is very important. And
+
+165
+00:14:46,480 --> 00:14:51,140
+remember, as you will see, thank you. As you will
+
+166
+00:14:51,140 --> 00:14:55,200
+see, these are the models. They are made up of how
+
+167
+00:14:55,200 --> 00:15:02,050
+many words? One word exceptHad bitter and اتو
+
+168
+00:15:02,050 --> 00:15:03,970
+thank you very much would you read the models
+
+169
+00:15:03,970 --> 00:15:08,170
+please thank
+
+170
+00:15:08,170 --> 00:15:12,790
+you
+
+171
+00:15:12,790 --> 00:15:17,070
+very much okay as you see they are made up of one
+
+172
+00:15:17,070 --> 00:15:22,710
+word except what had bitter and thank you now look
+
+173
+00:15:22,710 --> 00:15:31,170
+look at the examples these are called whatsubject
+
+174
+00:15:31,170 --> 00:15:37,130
+to pronounce and personal pronouns right good now
+
+175
+00:15:37,130 --> 00:15:44,970
+usually with lexical verbs I say I can you can
+
+176
+00:15:44,970 --> 00:15:52,570
+sorry I I live you live he lives she lives but
+
+177
+00:15:52,570 --> 00:16:00,130
+look I can do okay you he
+
+178
+00:16:01,320 --> 00:16:10,580
+She, it, we, you, they، okay؟ So they have what؟
+
+179
+00:16:10,580 --> 00:16:15,280
+They have the same form، they are followed، they
+
+180
+00:16:15,280 --> 00:16:18,120
+have the same form، the same shape، they are not
+
+181
+00:16:18,120 --> 00:16:23,130
+changed according to pronounsمثل الكلمات الأساسية
+
+182
+00:16:23,130 --> 00:16:28,710
+أو الكلمات اللغية و هم دائما يتبعون من ماذا؟ يمكنك
+
+183
+00:16:28,710 --> 00:16:32,690
+أن تشرب، يمكنك أن تكتب، يمكنك أن تغادر، يمكنك أن
+
+184
+00:16:32,690 --> 00:16:35,770
+تغادر، يمكنك أن تغادر، يمكنك أن تغادر، يمكنك أن
+
+185
+00:16:35,770 --> 00:16:36,930
+تغادر، يمكنك أن تغادر، يمكنك أن تغادر، يمكنك أن
+
+186
+00:16:36,930 --> 00:16:47,030
+تغادر، يمكنك أن تغادر، يمكنك أن تغادر،
+
+187
+00:16:47,030 --> 00:16:48,550
+يمكنك
+
+188
+00:16:50,690 --> 00:16:56,410
+what do you think of this sentence? yes, who can
+
+189
+00:16:56,410 --> 00:17:03,190
+comment? yes, سماهر she can drop the s because the
+
+190
+00:17:03,190 --> 00:17:07,250
+mother did not add the s very good, thank you, we
+
+191
+00:17:07,250 --> 00:17:10,510
+should drop the s because they don't accept final
+
+192
+00:17:10,510 --> 00:17:16,800
+s with he she addOkay we say what she can do it
+
+193
+00:17:16,800 --> 00:17:18,980
+thank you very much yes what about the other
+
+194
+00:17:18,980 --> 00:17:23,240
+sentence now she who can read and make a comment
+
+195
+00:17:23,240 --> 00:17:27,780
+comment yes please دعا she can't do it we dropped
+
+196
+00:17:27,780 --> 00:17:32,650
+him because can can can didn't follow by twookay
+
+197
+00:17:32,650 --> 00:17:37,330
+can is not followed by two and not only can all
+
+198
+00:17:37,330 --> 00:17:40,310
+the modal verbs are not followed thank you the
+
+199
+00:17:40,310 --> 00:17:44,050
+other one yes read the other one read it yes and
+
+200
+00:17:44,050 --> 00:17:47,690
+what do you think of she can does it yeah what do
+
+201
+00:17:47,690 --> 00:17:51,820
+you think of this sentenceyes now what do you
+
+202
+00:17:51,820 --> 00:17:54,340
+think of this sentence again what do you think of
+
+203
+00:17:54,340 --> 00:18:03,420
+this sentence very good
+
+204
+00:18:03,420 --> 00:18:07,820
+so we cannot say she can does she can do she can
+
+205
+00:18:07,820 --> 00:18:11,520
+play right she can eat she can write models should
+
+206
+00:18:11,520 --> 00:18:17,770
+not be followed byshould be followed by base form
+
+207
+00:18:17,770 --> 00:18:28,990
+she can do and finally the last one yes أسماء she
+
+208
+00:18:28,990 --> 00:18:32,090
+can
+
+209
+00:18:32,090 --> 00:18:35,070
+do it thank you that's right they should be
+
+210
+00:18:35,070 --> 00:18:38,830
+followed by the base form again this is wonderful
+
+211
+00:18:38,830 --> 00:18:44,610
+now what about this sentenceماذا تفكر بهذه السلسلة
+
+212
+00:18:44,610 --> 00:18:49,110
+يا نادا؟ اقرأها يجب أن يذهب إلى الاجتماع يجب أن
+
+213
+00:18:49,110 --> 00:18:53,070
+يتبع الانفينيطيب لكي يتعامل معه يجب أن يتبع
+
+214
+00:18:53,070 --> 00:18:57,730
+الانفينيطيب، هذه إختيارًا، حسنًا؟ هذه إختيارًا،
+
+215
+00:18:57,730 --> 00:19:02,970
+لا، انظر يجب أن تذهب، يجب أن تأتي، يجب أن تكتب،
+
+216
+00:19:02,970 --> 00:19:08,770
+وما إلى ذلك، حسنًا، جيد الآن، اخبرنا، ماذا علمت من
+
+217
+00:19:08,770 --> 00:19:11,810
+هذه الصفحة؟what did you learn from this page؟ who
+
+218
+00:19:11,810 --> 00:19:15,710
+can make a summary؟ yes مروح some of the verbs
+
+219
+00:19:15,710 --> 00:19:21,770
+should be followed by the base form of the verb
+
+220
+00:19:21,770 --> 00:19:25,590
+again some of the verbs some of the verbs most of
+
+221
+00:19:25,590 --> 00:19:29,030
+them most of them some of them all of them what do
+
+222
+00:19:29,030 --> 00:19:31,910
+you think most of them most of them it means when
+
+223
+00:19:31,910 --> 00:19:34,530
+i say most of them it means that we have
+
+224
+00:19:34,530 --> 00:19:39,110
+exceptions yeah so some acceptsome accept other
+
+225
+00:19:39,110 --> 00:19:42,810
+forms let she complete what I mean is that most of
+
+226
+00:19:42,810 --> 00:19:48,750
+them like can, must, may .. these modifiers must
+
+227
+00:19:48,750 --> 00:19:52,510
+be followed by the best form of the verb without
+
+228
+00:19:52,510 --> 00:20:00,730
+too but some of them as ought or yes auto auto you
+
+229
+00:20:00,730 --> 00:20:06,890
+know by the way by the way now we lookable to be
+
+230
+00:20:06,890 --> 00:20:09,530
+able to are they mentioned in the modal
+
+231
+00:20:09,530 --> 00:20:13,150
+auxiliaries no they have other classification just
+
+232
+00:20:13,150 --> 00:20:17,990
+wait okay they have other classification so only
+
+233
+00:20:17,990 --> 00:20:20,970
+ought to yes only ought to we are speaking about
+
+234
+00:20:20,970 --> 00:20:24,850
+this one yes go on so the exception is what ought
+
+235
+00:20:24,850 --> 00:20:29,770
+to okay it must be followed by an infinitive which
+
+236
+00:20:29,770 --> 00:20:33,510
+is two plus the space from the verb thank you very
+
+237
+00:20:33,510 --> 00:20:40,430
+much goodnow phrasal models what
+
+238
+00:20:40,430 --> 00:20:46,580
+is the first one? can you read it? is it clear?no
+
+239
+00:20:46,580 --> 00:20:51,500
+you cannot be able to okay be able to so be able
+
+240
+00:20:51,500 --> 00:20:56,880
+to is classified as what a phrasal what okay it is
+
+241
+00:20:56,880 --> 00:21:00,440
+a classified as a phrasal model what are the other
+
+242
+00:21:00,440 --> 00:21:05,040
+phrasal models who can read them yes can you see
+
+243
+00:21:05,040 --> 00:21:08,020
+them read from your book if you cannot see be
+
+244
+00:21:08,020 --> 00:21:09,960
+going to do
+
+245
+00:21:15,280 --> 00:21:22,980
+have to do okay thank you very much now listen are
+
+246
+00:21:22,980 --> 00:21:28,760
+you able to are you able to i am able to he's able
+
+247
+00:21:28,760 --> 00:21:34,380
+he's not able to okayWe are going to visit. We are
+
+248
+00:21:34,380 --> 00:21:37,840
+going to play. We are going to ride. Be able to.
+
+249
+00:21:38,600 --> 00:21:41,100
+We are supposed to finish early today.
+
+250
+00:21:44,100 --> 00:21:49,400
+You have to study hard. Exams are coming. You have
+
+251
+00:21:49,400 --> 00:21:56,600
+to study hard. You have got to leave now. Now when
+
+252
+00:21:56,600 --> 00:22:01,480
+I say I'm not able to continuedoes it mean I can't
+
+253
+00:22:01,480 --> 00:22:06,160
+continue? yes yes good do they have the same
+
+254
+00:22:06,160 --> 00:22:11,580
+meaning? yes so now when I say I'm going to visit
+
+255
+00:22:11,580 --> 00:22:15,780
+him does it mean I will visit him? yes now what do
+
+256
+00:22:15,780 --> 00:22:20,060
+you understand? what would you say? yes please
+
+257
+00:22:23,640 --> 00:22:26,460
+Good thank you they have almost the same meaning
+
+258
+00:22:26,460 --> 00:22:35,180
+and be going to and will that's right that's right
+
+259
+00:22:35,180 --> 00:22:39,080
+they express what the same attitude the same
+
+260
+00:22:39,080 --> 00:22:43,240
+meaning they have almost the same meaning now
+
+261
+00:22:43,240 --> 00:22:47,620
+again they have a meaning or their meaning is
+
+262
+00:22:47,620 --> 00:22:51,360
+similar to what to some of the model auxiliaries
+
+263
+00:22:53,290 --> 00:22:57,890
+العنوان هو بعض الـ Modal Auxiliaries، والآن انظر،
+
+264
+00:22:57,890 --> 00:23:04,070
+ماذا يعني Modal Auxiliaries؟ هل هم Modals نفسهم؟
+
+265
+00:23:04,070 --> 00:23:11,270
+نعم، هم نفسهم، يسمونهم Modals و Modal Auxiliaries،
+
+266
+00:23:11,270 --> 00:23:13,050
+هم نفسهم
+
+267
+00:23:17,350 --> 00:23:23,170
+what do you notice? be able to do? going to do?
+
+268
+00:23:23,950 --> 00:23:30,830
+supposed to do? they are followed by two plus one
+
+269
+00:23:30,830 --> 00:23:33,090
+speaker please one speaker yes
+
+270
+00:23:39,950 --> 00:23:43,550
+very good that's right they should be followed by
+
+271
+00:23:43,550 --> 00:23:47,390
+two and the simple form of the verb it is the base
+
+272
+00:23:47,390 --> 00:23:51,090
+form the bare infinitive okay when i say you are
+
+273
+00:23:51,090 --> 00:23:55,710
+supposed to finish we are supposed to finish today
+
+274
+00:23:55,710 --> 00:24:01,370
+to finish to go to come to write and so on look at
+
+275
+00:24:01,370 --> 00:24:07,070
+this verb this exercise complete the requests with
+
+276
+00:24:07,070 --> 00:24:13,550
+whatI او you او you او
+
+277
+00:24:13,550 --> 00:24:23,570
+you او you او you او you او you او you او you او
+
+278
+00:24:23,570 --> 00:24:33,250
+you او you او you او you او you او you او you او
+
+279
+00:24:33,250 --> 00:24:33,570
+you او you او you
+
+280
+00:24:54,540 --> 00:25:01,340
+بقى 2 دقيقة و لم ينتهي الوقت
+
+281
+00:25:22,120 --> 00:25:27,420
+Okay, you are in a high today. Yes, tell me. Look,
+
+282
+00:25:27,640 --> 00:25:30,220
+I'm writing your answers, then we will discuss the
+
+283
+00:25:30,220 --> 00:25:33,920
+answers, okay? I write whatever you say. So could
+
+284
+00:25:33,920 --> 00:25:38,020
+I? Thank you. Number two. Yes, please. Could you?
+
+285
+00:25:40,840 --> 00:25:47,200
+Good. Yes, please. May I? Thank you. Next one.
+
+286
+00:25:47,660 --> 00:25:54,940
+Yes, please.Can you good thank you next one yes
+
+287
+00:25:54,940 --> 00:26:03,800
+please can i see next one yes would you hand and
+
+288
+00:26:03,800 --> 00:26:10,480
+the last one yeah will you please will you please
+
+289
+00:26:10,480 --> 00:26:13,820
+okay now let's look at the answers let's look at
+
+290
+00:26:13,820 --> 00:26:17,400
+the answers could i see that book thanks what do
+
+291
+00:26:17,400 --> 00:26:22,480
+you think of the answerit is a polite request okay
+
+292
+00:26:22,480 --> 00:26:26,840
+so can i use i yes i'm requesting something okay
+
+293
+00:26:26,840 --> 00:26:34,240
+thanks good now number two could could you hand me
+
+294
+00:26:34,240 --> 00:26:39,660
+that book could you hand me that book it is what
+
+295
+00:26:39,660 --> 00:26:42,860
+that's right it's a good answer but what do you
+
+296
+00:26:42,860 --> 00:26:49,240
+understand what do you understandOkay well it is a
+
+297
+00:26:49,240 --> 00:26:52,980
+polite request. Can .. a could can be used with
+
+298
+00:26:52,980 --> 00:26:58,820
+what? With I and you okay? So you can request
+
+299
+00:26:58,820 --> 00:27:03,000
+something for yourself and you can request the
+
+300
+00:27:03,000 --> 00:27:07,300
+others to do something for you right? Good thank
+
+301
+00:27:07,300 --> 00:27:13,680
+you. Now what about this one?also a polite request
+
+302
+00:27:13,680 --> 00:27:17,500
+but it's my formal thank you okay thank you it is
+
+303
+00:27:17,500 --> 00:27:25,020
+a polite request okay may I may I now can you hand
+
+304
+00:27:25,020 --> 00:27:27,180
+me that book it is also a polite request for
+
+305
+00:27:27,180 --> 00:27:30,420
+requesting something from other to do thank you
+
+306
+00:27:30,420 --> 00:27:36,680
+and can I it is also a polite request good now
+
+307
+00:27:36,680 --> 00:27:45,100
+would you okayو هل أنت؟ حسنًا، هم طلبات طبيعية.
+
+308
+00:27:45,800 --> 00:27:53,100
+الآن، كل المدالات في هذه التعليمات، حسنًا، يمكن أن
+
+309
+00:27:53,100 --> 00:27:57,940
+تكون استخدامة. نستخدمها مع I و U، إلا
+
+310
+00:28:03,030 --> 00:28:07,050
+what look it is used with you may very good okay
+
+311
+00:28:07,050 --> 00:28:12,190
+so may is used with what with I did we use it in
+
+312
+00:28:12,190 --> 00:28:18,490
+did we use it with you in this exercise no now why
+
+313
+00:28:18,490 --> 00:28:28,110
+we want to know just wait now may as you see may I
+
+314
+00:28:28,110 --> 00:28:33,380
+borrow your penthis is what a request as you said
+
+315
+00:28:33,380 --> 00:28:38,820
+this is a polite request please is written between
+
+316
+00:28:38,820 --> 00:28:39,820
+two brackets why
+
+317
+00:28:42,600 --> 00:28:46,820
+we can use it and you can drop it very good now
+
+318
+00:28:46,820 --> 00:28:52,380
+may I have your pen this is a polite request if
+
+319
+00:28:52,380 --> 00:28:56,420
+you want to be more polite you say you say what
+
+320
+00:28:56,420 --> 00:29:01,380
+please okay so you express we said models express
+
+321
+00:29:01,380 --> 00:29:06,220
+attitudesfeelings right? now how do you feel? you
+
+322
+00:29:06,220 --> 00:29:09,980
+are talking to your father, you are talking to
+
+323
+00:29:09,980 --> 00:29:13,600
+your teacher, you want to be more polite okay? so
+
+324
+00:29:13,600 --> 00:29:18,240
+you .. can you express the degrees of politeness?
+
+325
+00:29:18,980 --> 00:29:24,540
+could I borrow your pen? this is again what?this
+
+326
+00:29:24,540 --> 00:29:30,740
+is a polite request okay now could is a polite ..
+
+327
+00:29:30,740 --> 00:29:34,600
+could and may are used with polite requests but
+
+328
+00:29:34,600 --> 00:29:38,260
+the difference is what? which is more polite?
+
+329
+00:29:40,920 --> 00:29:46,440
+that's right it is more formal may is more formal
+
+330
+00:29:46,440 --> 00:29:51,520
+could is much more common we don't say it is less
+
+331
+00:29:51,520 --> 00:29:54,480
+polite it is very polite could is a polite used
+
+332
+00:29:54,480 --> 00:29:58,820
+with polite request okay but you know it is more
+
+333
+00:29:58,820 --> 00:30:01,960
+common than may may is used but it is formal
+
+334
+00:30:01,960 --> 00:30:06,140
+formal in writing for example in formal situations
+
+335
+00:30:06,140 --> 00:30:11,400
+attitudes and so onNow what about might؟ can I say
+
+336
+00:30:11,400 --> 00:30:16,700
+might؟ look might is also possible might I borrow
+
+337
+00:30:16,700 --> 00:30:17,240
+your pen
+
+338
+00:30:21,200 --> 00:30:25,980
+is it a polite request؟ yes it is a polite request
+
+339
+00:30:25,980 --> 00:30:29,980
+so it can also be used as a polite request but
+
+340
+00:30:29,980 --> 00:30:35,340
+again is it formal or informal? it is also formal
+
+341
+00:30:35,340 --> 00:30:40,560
+it is also formal now listen so we talked about
+
+342
+00:30:40,560 --> 00:30:48,510
+may you and might what about them?ميت ميت ميت ميت
+
+343
+00:30:48,510 --> 00:30:53,310
+ميت ميت ميت ميت ميت ميت ميت ميت ميت
+
+344
+00:31:09,210 --> 00:31:13,410
+thank you very much good now when I say could in
+
+345
+00:31:13,410 --> 00:31:16,770
+this situation could you please open the door
+
+346
+00:31:16,770 --> 00:31:21,190
+could you please open the door what is the tense
+
+347
+00:31:21,190 --> 00:31:28,070
+present okay present it is not past it doesn't
+
+348
+00:31:28,070 --> 00:31:33,530
+express the past okay it can also be used for the
+
+349
+00:31:33,530 --> 00:31:36,450
+future how can you give me a situation
+
+350
+00:31:38,940 --> 00:31:44,900
+could the teacher cover all the material in this
+
+351
+00:31:44,900 --> 00:31:48,820
+course for example؟ thank you it can be used to
+
+352
+00:31:48,820 --> 00:31:53,700
+express a present situation or a future situation
+
+353
+00:31:53,700 --> 00:32:00,020
+not a past situation not a past situation now if
+
+354
+00:32:00,020 --> 00:32:05,080
+somebody asks you could I have your pen what would
+
+355
+00:32:05,080 --> 00:32:11,010
+you say?could I have your pen sure this is
+
+356
+00:32:11,010 --> 00:32:14,590
+informal you can say it to your friend okay you
+
+357
+00:32:14,590 --> 00:32:17,050
+can say it to your friend sure this is a good
+
+358
+00:32:17,050 --> 00:32:20,970
+response but it is informal but a formal answer
+
+359
+00:32:20,970 --> 00:32:25,510
+you can say now listen I want I want to request
+
+360
+00:32:25,510 --> 00:32:30,430
+something from you and you give me a good response
+
+361
+00:32:30,430 --> 00:32:36,410
+okay now could I have your pen please of courseof
+
+362
+00:32:36,410 --> 00:32:41,350
+course yes of course of course yes of course or
+
+363
+00:32:41,350 --> 00:32:44,510
+certainly yes certainly could you please use it
+
+364
+00:32:44,510 --> 00:32:48,110
+among each other ask your friend to give you
+
+365
+00:32:48,110 --> 00:32:52,830
+something and respond in a polite way then ask her
+
+366
+00:32:52,830 --> 00:32:57,290
+and let she respond go on please use it use it all
+
+367
+00:32:57,290 --> 00:33:00,110
+of you request something from your friend
+
+368
+00:33:04,950 --> 00:33:12,450
+عشان انا انا انا
+
+369
+00:33:12,450 --> 00:33:21,370
+انا انا انا
+
+370
+00:33:21,370 --> 00:33:30,270
+انا
+
+371
+00:33:30,270 --> 00:33:39,560
+انا اناالان اسمع اسمع
+
+372
+00:33:39,560 --> 00:33:46,740
+انها تريد ان تغادر الحرارة و هي تطلب .. هي تطلب
+
+373
+00:33:46,740 --> 00:33:55,910
+مسموح فقط عندما احصل على نقلWhat does that mean؟
+
+374
+00:33:55,910 --> 00:34:02,210
+yes you can or when I say I shake my head it means
+
+375
+00:34:02,210 --> 00:34:07,590
+what؟ yes you can okay so okay this also has
+
+376
+00:34:07,590 --> 00:34:10,790
+another meaning if you shake it this way right
+
+377
+00:34:11,580 --> 00:34:14,340
+Okay, so you can convey the message, you can
+
+378
+00:34:14,340 --> 00:34:18,600
+convey the response to the speaker by shaking your
+
+379
+00:34:18,600 --> 00:34:22,540
+head, okay, whether you accept or not, okay, or by
+
+380
+00:34:22,540 --> 00:34:26,500
+making what؟ I know, that's right, thank you Now,
+
+381
+00:34:29,380 --> 00:34:34,740
+would you .. would
+
+382
+00:34:34,740 --> 00:34:38,200
+you pass .. would you give me your pen, please?
+
+383
+00:34:39,180 --> 00:34:42,620
+would you give me your pen please؟ we talked about
+
+384
+00:34:42,620 --> 00:34:46,560
+can and could me and my okay now this is another
+
+385
+00:34:46,560 --> 00:34:49,360
+way what do you think of this request when i say
+
+386
+00:34:49,360 --> 00:34:53,440
+would you pass the salt please is it a polite
+
+387
+00:34:53,440 --> 00:34:59,770
+request okay will you please pass the saltهل هذه
+
+388
+00:34:59,770 --> 00:35:05,350
+طلبة صادمة؟ نعم هذا صحيح ماهي الفرق بين would you
+
+389
+00:35:05,350 --> 00:35:08,430
+pass و will you pass؟ would you give و will you
+
+390
+00:35:08,430 --> 00:35:14,010
+give؟ ماهي الفرق بالمعنى؟ with
+
+391
+00:35:14,010 --> 00:35:20,130
+polite request هه؟ with polite request هم تقريبا
+
+392
+00:35:20,130 --> 00:35:25,370
+.. ماذا؟ هم تقريبا نفسهم هم تقريبا نفسهم، لكن
+
+393
+00:35:25,370 --> 00:35:32,060
+ماذا؟would you is
+
+394
+00:35:32,060 --> 00:35:35,820
+more common and more polite okay they are the same
+
+395
+00:35:35,820 --> 00:35:39,620
+in being polite but which is more polite would is
+
+396
+00:35:39,620 --> 00:35:40,720
+more polite
+
+397
+00:35:43,730 --> 00:35:51,250
+العقل يمكن أن يكون ادعى بماذا؟ كيف؟ ب .. ب ..
+
+398
+00:35:51,250 --> 00:35:54,730
+بالطريقة التي تتكلمين بالطريقة التي تتكلمين
+
+399
+00:35:54,730 --> 00:35:56,850
+بالطريقة التي تتكلمين بالطريقة التي تتكلمين
+
+400
+00:35:56,850 --> 00:35:56,870
+بالطريقة التي تتكلمين بالطريقة التي تتكلمين
+
+401
+00:35:56,870 --> 00:35:57,470
+بالطريقة التي تتكلمن بالطريقة التي تتكلمن بالطريقة
+
+402
+00:35:57,470 --> 00:35:58,350
+التي تتكلمن بالطريقة التي تتكلمن بالطريقة التي
+
+403
+00:35:58,350 --> 00:36:04,190
+تتكلمن بالطريقة التي تتكلمن بالطريقة التي تتكلمن
+
+404
+00:36:04,190 --> 00:36:05,590
+بالطريقة التي تتكلمن بالطريقة التي تتكلمن بالطريقة
+
+405
+00:36:05,590 --> 00:36:08,210
+التي تتكلمن بالطريقة التي تتكلمن بالطريقة التي
+
+406
+00:36:08,210 --> 00:36:12,570
+تتكلمن بالطريقة التي تتكلمن بالطريقة التي تتكلم
+
+407
+00:36:31,320 --> 00:36:42,140
+انتظر انتظر انتظر انتظر انتظر انتظر انتظر انتظر
+
+408
+00:36:43,270 --> 00:36:47,590
+it's about the questions و هو الاطبق in response
+
+409
+00:36:47,590 --> 00:36:52,770
+again okay also the answer really also the answer
+
+410
+00:36:52,770 --> 00:37:00,810
+you know now again for example write your voice
+
+411
+00:37:00,810 --> 00:37:06,110
+when you ask a questionwhen you feel nervous for
+
+412
+00:37:06,110 --> 00:37:09,670
+example would you like this you are right you are
+
+413
+00:37:09,670 --> 00:37:12,630
+completely right we are coming to this point yes
+
+414
+00:37:12,630 --> 00:37:13,130
+yeah
+
+415
+00:37:17,560 --> 00:37:21,360
+أنت محق، شكرا جزيلا لك، لذا مرة أخرى، المعرفة
+
+416
+00:37:21,360 --> 00:37:26,200
+للطبالية يمكن أن تكون تدفعها بصوتك، أما أنك تطلبها
+
+417
+00:37:26,200 --> 00:37:30,660
+أو أنك تجيب عليها، حسنا؟ شكرا لك، أنت محق. على
+
+418
+00:37:30,660 --> 00:37:33,440
+سبيل المثال، عندما أسألك .. عندما أسأل .. عندما ..
+
+419
+00:37:33,440 --> 00:37:40,370
+عندما كنت طلابأسألك كطب كطب بمطالبة مع صوت حب على
+
+420
+00:37:40,370 --> 00:37:45,790
+سبيل المثال هل يمكنك أن تتحدث .. هل يمكنك أن تتحدث
+
+421
+00:37:45,790 --> 00:37:47,250
+.. هل يمكنك أن تتحدث .. هل يمكنك أن تتحدث .. هل
+
+422
+00:37:47,250 --> 00:37:47,350
+يمكنك أن تتحدث .. هل يمكنك أن تتحدث .. هل يمكنك أن
+
+423
+00:37:47,350 --> 00:37:47,830
+تتحدث .. هل يمكنك أن تتحدث .. هل يمكنك أن تتحدث ..
+
+424
+00:37:47,830 --> 00:37:48,650
+هل يمكنك أن تتحدث .. هل يمكنك أن تتحدث .. هل يمكنك
+
+425
+00:37:48,650 --> 00:37:55,050
+أن تتحدث .. هل يمكنك أن تتحدث .. هل يمكنك أن تتحدث
+
+426
+00:37:55,050 --> 00:37:59,290
+.. هل يمكنك أن تتحدث .. هل يمكنك أن تتحدث .. هل
+
+427
+00:37:59,290 --> 00:38:04,180
+يمكنك أن تتحدث .. هل يمكنك أن تتحدثهذا يعني كم
+
+428
+00:38:04,180 --> 00:38:08,160
+شخصية تريد ان تكون او تكون مع المستخدم
+
+429
+00:38:11,340 --> 00:38:18,900
+what about could you and would you they have the
+
+430
+00:38:18,900 --> 00:38:24,320
+same meaning we said would you is used to express
+
+431
+00:38:24,320 --> 00:38:28,180
+a polite request and what about could you okay
+
+432
+00:38:28,180 --> 00:38:32,520
+they have what the same meaning but they have a
+
+433
+00:38:32,520 --> 00:38:35,640
+little difference they have a little difference
+
+434
+00:38:35,640 --> 00:38:36,500
+now
+
+435
+00:38:38,880 --> 00:38:44,580
+I want to call my friend. I want to call my
+
+436
+00:38:44,580 --> 00:38:48,180
+friend. Look, I can see that she is having a
+
+437
+00:38:48,180 --> 00:38:51,660
+mobile. Could you give me your mobile? Could you
+
+438
+00:38:51,660 --> 00:38:54,960
+give me your telephone please? Could you give me
+
+439
+00:38:54,960 --> 00:38:59,630
+your telephone please? I know that she canأنا أعرف
+
+440
+00:38:59,630 --> 00:39:04,410
+أن هذا ممكن ، إنه ممكن لها أن تعطي، أليس كذلك؟ لكن
+
+441
+00:39:04,410 --> 00:39:08,450
+نادا لا أعرف إذا كانت لديها هاتف في حقيبتها أو لا
+
+442
+00:39:08,450 --> 00:39:13,070
+أو إذا كانت تحمل هاتفها أو لا ، أنا لست متأكد إنه
+
+443
+00:39:13,070 --> 00:39:20,030
+ممكن أو لا لها ، لذلك أقول هل أستخدم هاتفك أو هل
+
+444
+00:39:20,030 --> 00:39:25,770
+يمكنك أن تعطيني هاتفك؟ هل يمكنك أن تعطيني هاتفك؟
+
+445
+00:39:26,380 --> 00:39:29,500
+Okay I don't know whether it is possible it is a
+
+446
+00:39:29,500 --> 00:39:34,160
+request but I'm sure that she's having okay a
+
+447
+00:39:34,160 --> 00:39:36,520
+telephone with her and she's using the telephone
+
+448
+00:39:36,520 --> 00:39:39,740
+and she has she's always having a credit in her
+
+449
+00:39:39,740 --> 00:39:44,520
+telephone okay so could you give me your telephone
+
+450
+00:39:44,520 --> 00:39:49,680
+please could you means again and it is possible
+
+451
+00:39:49,680 --> 00:39:54,000
+for you to do it is possible for you to do is that
+
+452
+00:39:54,000 --> 00:40:01,400
+clearno question now
+
+453
+00:40:01,400 --> 00:40:07,180
+look at this page can you please pass the salt can
+
+454
+00:40:07,180 --> 00:40:11,040
+you please pass the salt what do you think is it a
+
+455
+00:40:11,040 --> 00:40:18,500
+polite request can you is it a polite request just
+
+456
+00:40:18,500 --> 00:40:25,910
+a minute does less polite mean impoliteit is
+
+457
+00:40:25,910 --> 00:40:31,570
+polite okay now you are very polite with your
+
+458
+00:40:31,570 --> 00:40:35,410
+parents but you are less polite with your brothers
+
+459
+00:40:35,410 --> 00:40:38,930
+and sisters it doesn't mean that you are impolite
+
+460
+00:40:38,930 --> 00:40:42,770
+no you are polite with them you respect them and
+
+461
+00:40:42,770 --> 00:40:47,850
+they respect you okay but you say what so you keep
+
+462
+00:40:47,850 --> 00:40:50,830
+code for example for your parents for your teacher
+
+463
+00:40:50,830 --> 00:40:55,900
+and can can be used with okaythat's right between
+
+464
+00:40:55,900 --> 00:41:01,220
+your brothers, between your friends and so onNow
+
+465
+00:41:01,220 --> 00:41:06,140
+can you give me your telephone? Can you give me
+
+466
+00:41:06,140 --> 00:41:09,580
+your pencil? And so on. What's the response? How
+
+467
+00:41:09,580 --> 00:41:10,800
+can you respond that?
+
+468
+00:41:32,390 --> 00:41:37,550
+yes I'd be happy too thank you can I have your
+
+469
+00:41:37,550 --> 00:41:43,110
+pencil please okay yes I'd be glad too yes I'd be
+
+470
+00:41:43,110 --> 00:41:48,110
+happy too can I have your pencil please okay thank
+
+471
+00:41:48,110 --> 00:41:52,110
+you can I have your pencil please okay thank you
+
+472
+00:41:52,110 --> 00:41:58,020
+yes now also you can say whatOkay and this is an
+
+473
+00:41:58,020 --> 00:42:01,000
+easy and a nice word and with your reference you
+
+474
+00:42:01,000 --> 00:42:04,540
+say what you say sure but sometimes you know
+
+475
+00:42:04,540 --> 00:42:10,080
+sometimes you ميها you want to express another
+
+476
+00:42:10,080 --> 00:42:14,440
+situation okay a negative situation but also you
+
+477
+00:42:14,440 --> 00:42:19,480
+want to be polite okay now she wants she's
+
+478
+00:42:19,480 --> 00:42:24,520
+requesting my pen okay yes would you request my
+
+479
+00:42:24,520 --> 00:42:30,440
+pen مروحأهcould you please give me your pen I'd
+
+480
+00:42:30,440 --> 00:42:35,620
+like to but I need it in writing okay I'd like to
+
+481
+00:42:35,620 --> 00:42:39,220
+you know I'd like to I'm ready I want to give but
+
+482
+00:42:39,220 --> 00:42:43,940
+I need it in writing okay now again is it a
+
+483
+00:42:43,940 --> 00:42:47,400
+positive or a negative response negative I don't
+
+484
+00:42:47,400 --> 00:42:51,180
+want to give instead of saying no okay no I want
+
+485
+00:42:51,180 --> 00:42:55,760
+to be polite with her so I'd like to but again I
+
+486
+00:43:14,800 --> 00:43:17,600
+بارك الله فيكم و شكرا
+