| {"Unnamed: 0": 135, "Gene1": "sigmaB", "Gene2": "yvyD", "Keywords": "dependent, inducible", "Direct dependency relations": "-1", "INO Type": "induction", "INO ID": "INO_0000122", "Num. Keywords": 2, "Sentence": "In addition to the typical [PROTEIN1] sigmaB [/PROTEIN1]-dependent, stress- and starvation-inducible pattern, [PROTEIN2] yvyD [/PROTEIN2] is also induced in response to amino acid depletion."} | |
| {"Unnamed: 0": 115, "Gene1": "sigma(X)", "Gene2": "ypuN", "Keywords": "recognize, promoter ", "Direct dependency relations": "-1", "INO Type": "promoter-based regulation of transcription", "INO ID": "INO_0000079", "Num. Keywords": 2, "Sentence": "We overproduced and purified sigma(X) from Escherichia coli and demonstrate that in vitro, both sigma(A) and [PROTEIN1] sigma(X) [/PROTEIN1] holoenzymes recognize promoter elements within the sigX-[PROTEIN2] ypuN [/PROTEIN2] control region."} | |
| {"Unnamed: 0": 131, "Gene1": "sigmaH", "Gene2": "yvyD", "Keywords": "dependent, drives, expression, promoter", "Direct dependency relations": "MORE THAN TWO KEYWORDS", "INO Type": "positive regulation of transcription by binding to promoter", "INO ID": "INO_0000072", "Num. Keywords": 4, "Sentence": "The sigmaB-dependent promoter drives expression of yvyD under stress conditions and after glucose starvation, whereas a [PROTEIN1] sigmaH [/PROTEIN1]-dependent promoter is responsible for [PROTEIN2] yvyD [/PROTEIN2] transcription following amino acid limitation."} | |
| {"Unnamed: 0": 55, "Gene1": "sigmaB", "Gene2": "ydaG", "Keywords": "dependent", "Direct dependency relations": "ONE WORD", "INO Type": "gene expression regulation", "INO ID": "INO_0000044", "Num. Keywords": 1, "Sentence": "Three new [PROTEIN1] sigmaB [/PROTEIN1]-dependent genes (ydaE, [PROTEIN2] ydaG [/PROTEIN2] and yfkM) encoding proteins with still unknown functions were also described."} | |
| {"Unnamed: 0": 95, "Gene1": "sigma(K)", "Gene2": "cotC", "Keywords": "transcription", "Direct dependency relations": "ONE WORD", "INO Type": "gene transcription", "INO ID": "INO_0000173", "Num. Keywords": 1, "Sentence": "Transcription of the cotB, cotC, and [PROTEIN2] cotX [/PROTEIN2] genes by final [PROTEIN1] sigma(K) [/PROTEIN1] RNA polymerase is activated by a small, DNA-binding protein called GerE."} | |
| {"Unnamed: 0": 29, "Gene1": "RocR", "Gene2": "rocG", "Keywords": "requires, expression", "Direct dependency relations": "-1", "INO Type": "gene expression regulation", "INO ID": "INO_0000044", "Num. Keywords": 2, "Sentence": "The [PROTEIN2] rocG [/PROTEIN2] gene of Bacillus subtilis, encoding a catabolic glutamate dehydrogenase, is transcribed by SigL-containing RNA polymerase and requires for its expression [PROTEIN1] RocR [/PROTEIN1], a member of the NtrC/NifA family of proteins that bind to enhancer-like elements, called upstream activating sequences (UAS)."} | |
| {"Unnamed: 0": 157, "Gene1": "sigma W", "Gene2": "PBP4*", "Keywords": "regulon, includes", "Direct dependency relations": "nsubj(includes,regulon)", "INO Type": "gene expression regulation", "INO ID": "INO_0000044", "Num. Keywords": 2, "Sentence": "The [PROTEIN1] sigma W [/PROTEIN1] regulon includes a penicillin binding protein ([PROTEIN2] PBP4* [/PROTEIN2]) and a co-transcribed amino acid racemase (RacX), homologues of signal peptide peptidase (YteI), flotillin (YuaG), ABC transporters (YknXYZ), non-haem bromoperoxidase (YdjP), epoxide hydrolase (YfhM) and three small peptides with structural similarities to bacteriocin precursor polypeptides."} | |
| {"Unnamed: 0": 51, "Gene1": "SpoIIE", "Gene2": "SpoIIAA-P", "Keywords": "dephosphorylation", "Direct dependency relations": "ONE WORD", "INO Type": "dephosphorylation reaction", "INO ID": "MI:0203", "Num. Keywords": 1, "Sentence": "Dephosphorylation of [PROTEIN2] SpoIIAA-P [/PROTEIN2] by [PROTEIN1] SpoIIE [/PROTEIN1] is strictly dependent on the presence of the bivalent metal ions Mn2+ or Mg2+."} | |
| {"Unnamed: 0": 101, "Gene1": "SpoIIID", "Gene2": "cot", "Keywords": "gene expression, action", "Direct dependency relations": "-1", "INO Type": "gene expression regulation", "INO ID": "INO_0000044", "Num. Keywords": 2, "Sentence": "In vitro transcription experiments suggest that the differential pattern of [PROTEIN2] cot [/PROTEIN2] gene expression results from the combined action of GerE and another transcription factor, [PROTEIN1] SpoIIID [/PROTEIN1]."} | |
| {"Unnamed: 0": 145, "Gene1": "SpoIIAB", "Gene2": "sigma F", "Keywords": "inhibits ", "Direct dependency relations": "ONE WORD", "INO Type": "inhibition", "INO ID": "INO_0000124", "Num. Keywords": 1, "Sentence": "The class includes AsiA form bacteriophage T4, which inhibits Escherichia coli sigma 70; FlgM, present in both gram-positive and gram-negative bacteria, which inhibits the flagella sigma factor sigma 28; [PROTEIN1] SpoIIAB [/PROTEIN1], which inhibits the sporulation-specific sigma factor,[PROTEIN2] sigma F [/PROTEIN2]and sigma G, of Bacillus subtilis; RbsW of B. subtilis, which inhibits stress response sigma factor sigma B; and DnaK, a general regulator of the heat shock response, which in bacteria inhibits the heat shock sigma factor sigma 32."} | |
| {"Unnamed: 0": 19, "Gene1": "sigmaB", "Gene2": "katX", "Keywords": "dependent, expression", "Direct dependency relations": "amod(expression, sigmaB-dependent)", "INO Type": "gene expression regulation", "INO ID": "INO_0000044", "Num. Keywords": 2, "Sentence": "Therefore, the physiological role of [PROTEIN1] sigmaB [/PROTEIN1]-dependent [PROTEIN2] katX [/PROTEIN2] expression remains obscure."} | |
| {"Unnamed: 0": 85, "Gene1": "SigL", "Gene2": "bkd", "Keywords": "expression, induced, depended, presence", "Direct dependency relations": "MORE THAN TWO KEYWORDS", "INO Type": "positive regulation of gene expression", "INO ID": "INO_0000038", "Num. Keywords": 4, "Sentence": "The expression of the [PROTEIN2] bkd [/PROTEIN2] operon was induced by the presence of isoleucine or valine in the growth medium and depended upon the presence of the sigma factor [PROTEIN1] SigL [/PROTEIN1], a member of the sigma 54 family."} | |
| {"Unnamed: 0": 15, "Gene1": "sigma(G)", "Gene2": "rsfA", "Keywords": "expression, control", "Direct dependency relations": "nsubj(control, expression)", "INO Type": "gene expression regulation", "INO ID": "INO_0000044", "Num. Keywords": 2, "Sentence": "The expression of [PROTEIN2] rsfA [/PROTEIN2] is under the control of both sigma(F) and [PROTEIN1] sigma(G) [/PROTEIN1]."} | |
| {"Unnamed: 0": 66, "Gene1": "GerE", "Gene2": "cotD", "Keywords": "repressed, transcription", "Direct dependency relations": "-1", "INO Type": "negative regulation of gene transcription", "INO ID": "INO_0000042", "Num. Keywords": 2, "Sentence": "A low level of GerE activated transcription of cotD by sigmaK RNA polymerase in vitro, but a higher level of [PROTEIN1] GerE [/PROTEIN1] repressed [PROTEIN2] cotD [/PROTEIN2] transcription."} | |
| {"Unnamed: 0": 24, "Gene1": "SpoIIAB", "Gene2": "sigmaF", "Keywords": "controlled", "Direct dependency relations": "ONE WORD", "INO Type": "controling", "INO ID": "INO_0000057", "Num. Keywords": 1, "Sentence": "[PROTEIN2] sigmaF [/PROTEIN2] is controlled by a regulatory cascade involving an anti-sigma factor, [PROTEIN1] SpoIIAB [/PROTEIN1], an anti-anti-sigma factor, SpoIIAA, and a membrane-bound phosphatase, SpoIIE, which converts the inactive, phosphorylated form of SpoIIAA back to the active form."} | |
| {"Unnamed: 0": 30, "Gene1": "sigma(54)", "Gene2": "rocG", "Keywords": "dependent", "Direct dependency relations": "ONE WORD", "INO Type": "gene expression regulation", "INO ID": "INO_0000044", "Num. Keywords": 1, "Sentence": "Unlike the case for other [PROTEIN1] sigma(54) [/PROTEIN1]-dependent genes, [PROTEIN2] rocG [/PROTEIN2] has no UAS; instead, its expression depends on a sequence located 1.5 kilobases downstream of the rocG promoter, beyond the end of the rocG coding region."} | |
| {"Unnamed: 0": 132, "Gene1": "sigmaB", "Gene2": "yvyD", "Keywords": "member of, regulons", "Direct dependency relations": "nmod:of(member, regulons)", "INO Type": "gene expression regulation", "INO ID": "INO_0000044", "Num. Keywords": 2, "Sentence": "This indicates that the [PROTEIN2] yvyD [/PROTEIN2] gene product, being a member of both the [PROTEIN1] sigmaB [/PROTEIN1] and sigmaH regulons, might negatively regulate the activity of the sigmaL regulon."} | |
| {"Unnamed: 0": 105, "Gene1": "GerE", "Gene2": "cotC", "Keywords": "activate, transcription", "Direct dependency relations": "amod(transcription, activate)", "INO Type": "activation of gene transcription", "INO ID": "INO_0000051", "Num. Keywords": 2, "Sentence": "A low concentration of [PROTEIN1] GerE [/PROTEIN1] activated cotB transcription by final sigma(K) RNA polymerase, whereas a higher concentration was needed to activate transcription of cotX or [PROTEIN2] cotC [/PROTEIN2]."} | |
| {"Unnamed: 0": 152, "Gene1": "sigmaG", "Gene2": "sspL", "Keywords": "recognized ", "Direct dependency relations": "ONE WORD", "INO Type": "association", "INO ID": "MI_0914", "Num. Keywords": 1, "Sentence": "The sspH and [PROTEIN2] sspL [/PROTEIN2] genes are recognized primarily by the forespore-specific sigma factor for RNA polymerase, [PROTEIN1] sigmaG [/PROTEIN1]; the sspN-tlp operon is recognized equally well by sigmaG and the other forespore-specific sigma factor, sigmaF."} | |
| {"Unnamed: 0": 16, "Gene1": "sigma(K)", "Gene2": "cwlH", "Keywords": "dependent", "Direct dependency relations": "ONE WORD", "INO Type": "gene expression regulation", "INO ID": "INO_0000044", "Num. Keywords": 1, "Sentence": "Expression of the [PROTEIN1] sigma(K) [PROTEIN1]-dependent [PROTEIN2] cwlH [/PROTEIN2] gene depended on gerE."} | |
| {"Unnamed: 0": 75, "Gene1": "ComK", "Gene2": "flgM", "Keywords": "increasing, production", "Direct dependency relations": "dobj(increasing,production)", "INO Type": "positive regulation of protein translation", "INO ID": "INO_0000053", "Num. Keywords": 2, "Sentence": "[PROTEIN1] ComK [/PROTEIN1] negatively controls the transcription of hag by stimulating the transcription of comF-[PROTEIN2] flgM [/PROTEIN2], thereby increasing the production of the FlgM antisigma factor that inhibits sigmaD activity."} | |
| {"Unnamed: 0": 18, "Gene1": "EsigmaF", "Gene2": "KatX", "Keywords": "level, depends", "Direct dependency relations": "nsubj(depends, level)", "INO Type": "gene expression regulation", "INO ID": "INO_0000044", "Num. Keywords": 2, "Sentence": "Our results indicate that the level of [PROTEIN2] KatX [/PROTEIN2] level in outgrowing spores depends mainly on [PROTEIN1] EsigmaF [/PROTEIN1], because sigB mutants show normal KatX activity in dormant and outgrowing spores."} | |
| {"Unnamed: 0": 12, "Gene1": "sigma(H)", "Gene2": "spo0A", "Keywords": "dependent, expression", "Direct dependency relations": "amod(expression, dependent)", "INO Type": "gene expression regulation", "INO ID": "INO_0000044", "Num. Keywords": 2, "Sentence": "In the shaA mutant, [PROTEIN1] sigma(H) [/PROTEIN1]-dependent expression of [PROTEIN2] spo0A [/PROTEIN2] and spoVG at an early stage of sporulation was sensitive to external NaCl."} | |
| {"Unnamed: 0": 9, "Gene1": "sigma(G)", "Gene2": "ywhE", "Keywords": "expression, controlled", "Direct dependency relations": "-1", "INO Type": "gene expression regulation", "INO ID": "INO_0000044", "Num. Keywords": 2, "Sentence": "Analysis of the expression of a translational ywhE-lacZ fusion showed that [PROTEIN2] ywhE [PROTEIN2] expression is sporulation-specific, and is controlled predominantly by the forespore-specific sigma factor sigma(F), and to a lesser extent by [PROTEIN1] sigma(G) [/PROTEIN1]."} | |
| {"Unnamed: 0": 31, "Gene1": "sigmaH", "Gene2": "phrC", "Keywords": "controlling, transcription", "Direct dependency relations": "amod(transcription, controlling)", "INO Type": "regulation of transcription", "INO ID": "INO_0000032", "Num. Keywords": 2, "Sentence": "In addition to controlling transcription of [PROTEIN2] phrC [/PROTEIN2], [PROTEIN1] sigmaH [/PROTEIN1] appears to control expression of at least one other gene required for production of CSF."} | |