| {"Unnamed: 0": 60, "Gene1": "GerE", "Gene2": "sigK", "Keywords": "inhibits, transcription", "Direct dependency relations": "dobj(inhibits, transcription)", "INO Type": "inhibition of gene transcription", "INO ID": "INO_0000046", "Num. Keywords": 2, "Sentence": "Previously, it was shown that the [PROTEIN1] GerE [/PROTEIN1] protein inhibits transcription in vitro of the [PROTEIN2] sigK [/PROTEIN2] gene encoding sigmaK."} | |
| {"Unnamed: 0": 106, "Gene1": "sigma(K)", "Gene2": "cotB", "Keywords": "activated, transcription", "Direct dependency relations": "dobj(activated,transcription)", "INO Type": "activation of gene transcription", "INO ID": "INO_0000051", "Num. Keywords": 2, "Sentence": "A low concentration of GerE activated [PROTEIN2] cotB [PROTEIN2] transcription by final [PROTEIN1] sigma(K) [/PROTEIN1] RNA polymerase, whereas a higher concentration was needed to activate transcription of cotX or cotC."} | |
| {"Unnamed: 0": 78, "Gene1": "sigma X", "Gene2": "CsbB", "Keywords": "contributes, expression", "Direct dependency relations": "nmod(contributes,expression)", "INO Type": "gene expression regulation", "INO ID": "INO_0000044", "Num. Keywords": 2, "Sentence": "[PROTEIN1] sigma X [/PROTEIN1] also contributes to the expression of [PROTEIN2] CsbB [/PROTEIN2], a putative membrane-bound glucosyl transferase that is partially controlled by the sigma B stress response sigma factor."} | |
| {"Unnamed: 0": 3, "Gene1": "Spo0A", "Gene2": "spoIIG", "Keywords": "transcription, depends", "Direct dependency relations": "nsubj(depends, transcription)", "INO Type": "regulation of transcription", "INO ID": "INO_0000032", "Num. Keywords": 2, "Sentence": "In this mutant, expression of the [PROTEIN2] spoIIG [/PROTEIN2] gene, whose transcription depends on both sigma(A) and the phosphorylated Spo0A protein, [PROTEIN1] Spo0A [/PROTEIN1]~P, a major transcription factor during early stages of sporulation, was greatly reduced at 43 degrees C."} | |
| {"Unnamed: 0": 163, "Gene1": "sigma W", "Gene2": "YfhM", "Keywords": "regulon, includes", "Direct dependency relations": "nsubj(includes,regulon)", "INO Type": "gene expression regulation", "INO ID": "INO_0000044", "Num. Keywords": 2, "Sentence": "The [PROTEIN1] sigma W [/PROTEIN1] regulon includes a penicillin binding protein (PBP4*) and a co-transcribed amino acid racemase (RacX), homologues of signal peptide peptidase (YteI), flotillin (YuaG), ABC transporters (YknXYZ), non-haem bromoperoxidase (YdjP), epoxide hydrolase ([PROTEIN2] YfhM [/PROTEIN2]) and three small peptides with structural similarities to bacteriocin precursor polypeptides."} | |
| {"Unnamed: 0": 47, "Gene1": "SpoIIE", "Gene2": "sigmaF", "Keywords": "activation, requires", "Direct dependency relations": "nsubj(requires, activation)\r\n", "INO Type": "regulation of gene activation", "INO ID": "INO_0000037", "Num. Keywords": 2, "Sentence": "Cell-specific activation of transcription factor [PROTEIN2] sigmaF [/PROTEIN2] during sporulation in Bacillus subtilis requires the formation of the polar septum and the activity of a serine phosphatase ([PROTEIN1] SpoIIE [/PROTEIN1]) located in the septum."} | |
| {"Unnamed: 0": 64, "Gene1": "GerE", "Gene2": "cotD", "Keywords": "low level, activated, transcription", "Direct dependency relations": "MORE THAN TWO KEYWORDS", "INO Type": "activation of gene transcription by low level protein", "INO ID": "INO_0000052", "Num. Keywords": 3, "Sentence": "A low level of [PROTEIN1] GerE [/PROTEIN1] activated transcription of [PROTEIN2] cotD [/PROTEIN2] by sigmaK RNA polymerase in vitro, but a higher level of GerE repressed cotD transcription."} | |
| {"Unnamed: 0": 49, "Gene1": "SpoIIE", "Gene2": "sigmaF", "Keywords": "activates", "Direct dependency relations": "ONE WORD", "INO Type": "activation", "INO ID": "INO_0000024", "Num. Keywords": 1, "Sentence": "The [PROTEIN1] SpoIIE [/PROTEIN1] phosphatase indirectly activates [PROTEIN2] sigmaF [/PROTEIN2] by dephosphorylating a protein (SpoIIAA-P) in the pathway that controls the activity of the transcription factor."} | |
| {"Unnamed: 0": 154, "Gene1": "sigmaG", "Gene2": "tlp", "Keywords": "recognized ", "Direct dependency relations": "ONE WORD", "INO Type": "association", "INO ID": "MI_0914", "Num. Keywords": 1, "Sentence": "The sspH and sspL genes are recognized primarily by the forespore-specific sigma factor for RNA polymerase, [PROTEIN1] sigmaG [/PROTEIN1]; the sspN-[PROTEIN2] tlp [/PROTEIN2] operon is recognized equally well by sigmaG and the other forespore-specific sigma factor, sigmaF."} | |
| {"Unnamed: 0": 38, "Gene1": "Spo0A", "Gene2": "sigE", "Keywords": "phosphorylated, activator, transcription", "Direct dependency relations": "MORE THAN TWO KEYWORDS", "INO Type": "activation of gene transcription by phosphorylated protein", "INO ID": "INO_0000081", "Num. Keywords": 3, "Sentence": "Production of sigmaK about 1 h earlier than normal does affect [PROTEIN1] Spo0A [/PROTEIN1], which when phosphorylated is an activator of [PROTEIN2] sigE [/PROTEIN2] transcription."} | |
| {"Unnamed: 0": 96, "Gene1": "sigma(K)", "Gene2": "cotX", "Keywords": "transcription", "Direct dependency relations": "ONE WORD", "INO Type": "gene transcription", "INO ID": "INO_0000173", "Num. Keywords": 1, "Sentence": "Transcription of the cotB, cotC, and [PROTEIN2] cotX [/PROTEIN2] genes by final [PROTEIN1] sigma(K) [/PROTEIN1] RNA polymerase is activated by a small, DNA-binding protein called GerE."} | |
| {"Unnamed: 0": 141, "Gene1": "ClpX", "Gene2": "sigmaA", "Keywords": "dependent, stimulation", "Direct dependency relations": "amod(stimulation, ClpX-dependent)", "INO Type": "positve regulation of protein activity", "INO ID": "INO_0000104", "Num. Keywords": 2, "Sentence": "The addition of [PROTEIN1] ClpX [/PROTEIN1] to in vitro transcription reactions resulted in the stimulation of RNAP holoenzyme activity, but sigmaH-RNAP was observed to be more sensitive to ClpX-dependent stimulation than [PROTEIN2] sigmaA [/PROTEIN2]-RNAP."} | |
| {"Unnamed: 0": 129, "Gene1": "sigmaA", "Gene2": "clpC", "Keywords": "preventing, transcription", "Direct dependency relations": "dobj(preventing,transcription)", "INO Type": "inhibition of gene transcription", "INO ID": "INO_0000046", "Num. Keywords": 2, "Sentence": "Our data demonstrate that the CtsR protein acts as a global repressor of the [PROTEIN2] clpC [/PROTEIN2] operon, as well as other class III heat shock genes, by preventing unstressed transcription from either the sigmaB- or [PROTEIN1] sigmaA [/PROTEIN1]-dependent promoter and might be inactivated or dissociate under inducing stress conditions."} | |
| {"Unnamed: 0": 158, "Gene1": "sigma W", "Gene2": "RacX", "Keywords": "regulon, includes", "Direct dependency relations": "nsubj(includes,regulon)", "INO Type": "gene expression regulation", "INO ID": "INO_0000044", "Num. Keywords": 2, "Sentence": "The [PROTEIN1] sigma W [/PROTEIN1] regulon includes a penicillin binding protein (PBP4*) and a co-transcribed amino acid racemase ([PROTEIN2] RacX [/PROTEIN2]), homologues of signal peptide peptidase (YteI), flotillin (YuaG), ABC transporters (YknXYZ), non-haem bromoperoxidase (YdjP), epoxide hydrolase (YfhM) and three small peptides with structural similarities to bacteriocin precursor polypeptides."} | |
| {"Unnamed: 0": 59, "Gene1": "sigmaK", "Gene2": "gerE", "Keywords": "transcribed", "Direct dependency relations": "ONE WORD", "INO Type": "gene transcription", "INO ID": "INO_0000173", "Num. Keywords": 1, "Sentence": "Most cot genes, and the [PROTEIN2] gerE [/PROTEIN2] gene, are transcribed by [PROTEIN1] sigmaK [/PROTEIN1] RNA polymerase."} | |
| {"Unnamed: 0": 33, "Gene1": "YfhP", "Gene2": "yfhQ", "Keywords": "negative regulator, transcription", "Direct dependency relations": "nmod:for(regulator, transcription); amod(regulator, negative)", "INO Type": "negative regulation of transcription", "INO ID": "INO_0000074", "Num. Keywords": 2, "Sentence": "These results suggest that [PROTEIN1] YfhP [/PROTEIN1] may act as a negative regulator for the transcription of [PROTEIN2] yfhQ [/PROTEIN2], yfhR, sspE and yfhP."} | |
| {"Unnamed: 0": 42, "Gene1": "sigmaK", "Gene2": "sigE", "Keywords": "expression, negatively regulated", "Direct dependency relations": "nsubjpass(regulated, expression); advmod(regulated, negatively)", "INO Type": "negative regulation of gene expression", "INO ID": "INO_0000039", "Num. Keywords": 2, "Sentence": "In the mother cell compartment of sporulating cells, expression of the sigE gene, encoding the earlier-acting sigma factor, [PROTEIN2] sigmaE [/PROTEIN2], is negatively regulated by the later-acting sigma factor, [PROTEIN1] sigmaK [/PROTEIN1]."} | |
| {"Unnamed: 0": 151, "Gene1": "sigmaG", "Gene2": "sspH", "Keywords": "recognized ", "Direct dependency relations": "ONE WORD", "INO Type": "association", "INO ID": "MI_0914", "Num. Keywords": 1, "Sentence": "The [PROTEIN2] sspH [/PROTEIN2] and sspL genes are recognized primarily by the forespore-specific sigma factor for RNA polymerase, [PROTEIN1] sigmaG [/PROTEIN1]; the sspN-tlp operon is recognized equally well by sigmaG and the other forespore-specific sigma factor, sigmaF."} | |
| {"Unnamed: 0": 73, "Gene1": "ComK", "Gene2": "hag", "Keywords": "negatively controls, transcription", "Direct dependency relations": "dobj(controls, transcription); advmod(controls, negatively)", "INO Type": "negative regulation of gene transcription", "INO ID": "INO_0000042", "Num. Keywords": 2, "Sentence": "[PROTEIN1] ComK [/PROTEIN1] negatively controls the transcription of [PROTEIN2] hag [/PROTEIN2] by stimulating the transcription of comF-flgM, thereby increasing the production of the FlgM antisigma factor that inhibits sigmaD activity."} | |
| {"Unnamed: 0": 93, "Gene1": "SpoIIID", "Gene2": "cotB", "Keywords": "bind", "Direct dependency relations": "ONE WORD", "INO Type": "direct interaction", "INO ID": "MI_0407", "Num. Keywords": 1, "Sentence": "DNase I footprinting showed that [PROTEIN1] SpoIIID [/PROTEIN1] binds strongly to two sites in the cotC promoter region, binds weakly to one site in the cotX promoter, and does not bind specifically to [PROTEIN2] cotB [/PROTEIN2]."} | |
| {"Unnamed: 0": 117, "Gene1": "PhoP~P", "Gene2": "tagD", "Keywords": "repress, transcription", "Direct dependency relations": "dobj(repress,transcription)", "INO Type": "inhibition of gene transcription", "INO ID": "INO_0000046", "Num. Keywords": 2, "Sentence": "The results indicate that [PROTEIN1] PhoP~P [/PROTEIN1] is sufficient to repress the transcription of the [PROTEIN2] tagA [/PROTEIN2]and tagD promoters and also to activate the transcription of the tuaA promoter."} | |