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0 | KinC | Spo0A~P | responsible, production | nmod(responsible, production) | regulation of translation | INO_0000034 | 2 | In vivo studies of the activity of four of the kinases, KinA, [PROTEIN1] KinC [/PROTEIN1], KinD (ykvD) and KinE (ykrQ), using abrB transcription as an indicator of [PROTEIN2] Spo0A~P [/PROTEIN2] level, revealed that KinC and KinD were responsible for Spo0A~P production during the exponential phase of growth in the absence of KinA and KinB. |
1 | KinD | Spo0A~P | responsible, production | nmod(responsible, production) | regulation of translation | INO_0000034 | 2 | In vivo studies of the activity of four of the kinases, KinA, KinC, [PROTEIN1] KinD [/PROTEIN1] (ykvD) and KinE (ykrQ), using abrB transcription as an indicator of [PROTEIN2] Spo0A~P [/PROTEIN2] level, revealed that KinC and KinD were responsible for Spo0A~P production during the exponential phase of growth in the absence of KinA and KinB. |
2 | sigma(A) | spoIIG | transcription, depends | nsubj(depends, transcription) | regulation of transcription | INO_0000032 | 2 | In this mutant, expression of the [PROTEIN2] spoIIG [/PROTEIN2] gene, whose transcription depends on both [PROTEIN1] sigma(A) [/PROTEIN1] and the phosphorylated Spo0A protein, Spo0A~P, a major transcription factor during early stages of sporulation, was greatly reduced at 43 degrees C. |
3 | Spo0A | spoIIG | transcription, depends | nsubj(depends, transcription) | regulation of transcription | INO_0000032 | 2 | In this mutant, expression of the [PROTEIN2] spoIIG [/PROTEIN2] gene, whose transcription depends on both sigma(A) and the phosphorylated [PROTEIN1] Spo0A [/PROTEIN1] protein, Spo0A~P, a major transcription factor during early stages of sporulation, was greatly reduced at 43 degrees C. |
4 | SigE | ydhD | transcription, dependent | nsubj(dependent, transcription) | regulation of transcription | INO_0000032 | 2 | Transcription of [PROTEIN2] ydhD [/PROTEIN2] was dependent on [PROTEIN1] SigE [/PROTEIN1], and the mRNA was detectable from 2 h after the cessation of logarithmic growth (T2 of sporulation). |
5 | SigK | ykuD | transcribed | ONE WORD | regulation of transcription | INO_0000032 | 1 | [PROTEIN2] ykuD [/PROTEIN2] was transcribed by [PROTEIN1] SigK [/PROTEIN1] RNA polymerase from T4 of sporulation. |
6 | SigK | ykvP | essential, expression | nmod(essential, expression) | gene expression regulation | INO_0000044 | 2 | Both [PROTEIN1] SigK [/PROTEIN1] and GerE were essential for [PROTEIN2] ykvP [/PROTEIN2] expression, and this gene was transcribed from T5 of sporulation. |
7 | GerE | ykvP | essential, expression | nmod(essential, expression) | gene expression regulation | INO_0000044 | 2 | Both SigK and [PROTEIN1] GerE [/PROTEIN1] were essential for [PROTEIN2] ykvP [/PROTEIN2] expression, and this gene was transcribed from T5 of sporulation. |
8 | sigma(F) | ywhE | expression, controlled | -1 | gene expression regulation | INO_0000044 | 2 | Analysis of the expression of a translational [PROTEIN1] ywhE [/PROTEIN1]-lacZ fusion showed that ywhE expression is sporulation-specific, and is controlled predominantly by the forespore-specific sigma factor [PROTEIN1] sigma(F) [/PROTEIN1], and to a lesser extent by sigma(G). |
10 | SpoIIE | sigma(F) | essential, activation | nmod:for(essential, activation) | regulation of gene activation | INO_0000037 | 2 | Secondly, [PROTEIN1] SpoIIE [/PROTEIN1] is essential for the activation of the first compartment-specific transcription factor [PROTEIN2] sigma(F) [/PROTEIN2] in the prespore. |
11 | FtsZ | SpoIIE | localization, dependent | nsubj(dependent, Localization) | regulation of protein location | INO_0000031 | 2 | Localization of [PROTEIN2] SpoIIE [/PROTEIN2] was shown to be dependent on the essential cell division protein [PROTEIN1] FtsZ [/PROTEIN1]. |
13 | sigma(H) | spoVG | dependent, expression | amod(expression, dependent) | gene expression regulation | INO_0000044 | 2 | In the shaA mutant, [PROTEIN1] sigma(H) [/PROTEIN1]-dependent expression of spo0A and [PROTEIN2] spoVG [/PROTEIN2] at an early stage of sporulation was sensitive to external NaCl. |
14 | sigma(F) | rsfA | expression, control | nsubj(control, expression) | gene expression regulation | INO_0000044 | 2 | The expression of [PROTEIN2] rsfA [/PROTEIN2] is under the control of both [PROTEIN1] sigma(F) [/PROTEIN1] and sigma(G). |
17 | gerE | cwlH | expression, depended | -1 | gene expression regulation | INO_0000044 | 2 | Expression of the sigma(K)-dependent [PROTEIN2] cwlH [/PROTEIN2] gene depended on [PROTEIN1] gerE [/PROTEIN1]. |
20 | sigmaB | katX | dependent, promoters | amod(promoters, sigmaF-dependent) | promoter-based regulation of transcription | INO_0000079 | 2 | The -10 and -35 sequences of the [PROTEIN1] sigmaB [/PROTEIN1]- and sigmaF-dependent promoters of [PROTEIN2] katX [/PROTEIN2] overlap, and the transcriptional start points used by EsigmaB and EsigmaF differ by only one nucleotide. |
21 | sigmaF | katX | dependent, promoters | amod(promoters, sigmaF-dependent) | promoter-based regulation of transcription | INO_0000079 | 2 | The -10 and -35 sequences of the sigmaB- and [PROTEIN1] sigmaF [/PROTEIN1]-dependent promoters of [PROTEIN2] katX [/PROTEIN2] overlap, and the transcriptional start points used by EsigmaB and EsigmaF differ by only one nucleotide. |
22 | sigmaB | katX | dependent | ONE WORD | gene expression regulation | INO_0000044 | 1 | We demonstrated that [PROTEIN2] katX [/PROTEIN2] is also a [PROTEIN1] sigmaB [/PROTEIN1]-dependent general stress gene, since it is strongly induced by heat, salt and ethanol stress, as well as by energy depletion. |
23 | SpoIIE | sigmaF | control, activation | nmod:of(control, activation) | regulation of gene activation | INO_0000037 | 2 | Taken together, the results support the idea that sequestration of [PROTEIN1] SpoIIE [/PROTEIN1] protein into the prespore plays an important role in the control of [PROTEIN2] sigmaF [/PROTEIN2] activation and in coupling this activation to septation. |
25 | SpoIIAA | sigmaF | controlled | ONE WORD | controling | INO_0000057 | 1 | [PROTEIN2] sigmaF [/PROTEIN2] is controlled by a regulatory cascade involving an anti-sigma factor, SpoIIAB, an anti-anti-sigma factor, [PROTEIN1] SpoIIAA [/PROTEIN1], and a membrane-bound phosphatase, SpoIIE, which converts the inactive, phosphorylated form of SpoIIAA back to the active form. |
26 | SpoIIE | sigmaF | controlled | ONE WORD | controling | INO_0000057 | 1 | [PROTEIN2] sigmaF [/PROTEIN2] is controlled by a regulatory cascade involving an anti-sigma factor, SpoIIAB, an anti-anti-sigma factor, SpoIIAA, and a membrane-bound phosphatase, [PROTEIN1] SpoIIE [/PROTEIN1], which converts the inactive, phosphorylated form of SpoIIAA back to the active form. |
27 | SpoIIE | SpoIIAA | converts, active | -1 | regulation of gene activation | INO_0000037 | 2 | sigmaF is controlled by a regulatory cascade involving an anti-sigma factor, SpoIIAB, an anti-anti-sigma factor, [PROTEIN2] SpoIIAA [/PROTEIN2], and a membrane-bound phosphatase, [PROTEIN1] SpoIIE [/PROTEIN1], which converts the inactive, phosphorylated form of SpoIIAA back to the active form. |
28 | SigL | rocG | transcribed | ONE WORD | gene transcription | INO_0000173 | 1 | The [PROTEIN2] rocG [/PROTEIN2] gene of Bacillus subtilis, encoding a catabolic glutamate dehydrogenase, is transcribed by [PROTEIN1] SigL [/PROTEIN1]-containing RNA polymerase and requires for its expression RocR, a member of the NtrC/NifA family of proteins that bind to enhancer-like elements, called upstream activating sequences (UAS). |
32 | E sigma E | yfhS | transcribed | ONE WORD | regulation of transcription | INO_0000032 | 1 | Northern blot and primer extension analyses indicated that [PROTEIN2] yfhS [/PROTEIN2] is transcribed by [PROTEIN1] E sigma E [/PROTEIN1] during sporulation. |
33 | YfhP | yfhQ | negative regulator, transcription | nmod:for(regulator, transcription); amod(regulator, negative) | negative regulation of transcription | INO_0000074 | 2 | These results suggest that [PROTEIN1] YfhP [/PROTEIN1] may act as a negative regulator for the transcription of [PROTEIN2] yfhQ [/PROTEIN2], yfhR, sspE and yfhP. |
34 | YfhP | yfhR | negative regulator, transcription | nmod:for(regulator, transcription); amod(regulator, negative) | negative regulation of transcription | INO_0000074 | 2 | These results suggest that [PROTEIN1] YfhP [/PROTEIN1] may act as a negative regulator for the transcription of yfhQ, [PROTEIN2] yfhR [/PROTEIN2], sspE and yfhP. |
35 | YfhP | sspE | negative regulator, transcription | nmod:for(regulator, transcription); amod(regulator, negative) | negative regulation of transcription | INO_0000074 | 2 | These results suggest that [PROTEIN1] YfhP [/PROTEIN1] may act as a negative regulator for the transcription of yfhQ, yfhR, [PROTEIN2] sspE [/PROTEIN2] and yfhP. |
36 | YfhP | yfhP | negative regulator, transcription | nmod:for(regulator, transcription); amod(regulator, negative) | negative regulation of transcription | INO_0000074 | 2 | These results suggest that [PROTEIN1] YfhP [/PROTEIN1] may act as a negative regulator for the transcription of yfhQ, yfhR, sspE and [PROTEIN2] yfhP [/PROTEIN2]. |
37 | sigmaK | Spo0A | production, affect | nsubj(affect, production) | gene expression regulation | INO_0000044 | 2 | Production of [PROTEIN1] sigmaK [/PROTEIN1] about 1 h earlier than normal does affect [PROTEIN2] Spo0A [/PROTEIN2], which when phosphorylated is an activator of sigE transcription. |
38 | Spo0A | sigE | phosphorylated, activator, transcription | MORE THAN TWO KEYWORDS | activation of gene transcription by phosphorylated protein | INO_0000081 | 3 | Production of sigmaK about 1 h earlier than normal does affect [PROTEIN1] Spo0A [/PROTEIN1], which when phosphorylated is an activator of [PROTEIN2] sigE [/PROTEIN2] transcription. |
39 | sigmaA | ald | promoter, recognized | nsubjpass(recognized, promoter) | promoter-based regulation of transcription | INO_0000079 | 2 | The [PROTEIN2] ald [/PROTEIN2] promoter, like the sigE promoter, is believed to be recognized by [PROTEIN1] sigmaA [/PROTEIN1] RNA polymerase, suggesting that sigmaK may inhibit sigmaA activity late in sporulation. |
40 | sigmaA | sigE | promoter, recognized | nsubjpass(recognized, promoter) | promoter-based regulation of transcription | INO_0000079 | 2 | The ald promoter, like the [PROTEIN2] sigE [/PROTEIN2] promoter, is believed to be recognized by [PROTEIN1] sigmaA [/PROTEIN1] RNA polymerase, suggesting that sigmaK may inhibit sigmaA activity late in sporulation. |
41 | sigmaK | sigmaA | inhibit, activity | dobj(inhibit, activity) | inhibition of protein activity | INO_0000070 | 2 | The ald promoter, like the sigE promoter, is believed to be recognized by [PROTEIN2] sigmaA [/PROTEIN2]RNA polymerase, suggesting that [PROTEIN1] sigmaK [/PROTEIN1] may inhibit sigmaA activity late in sporulation. |
42 | sigmaK | sigE | expression, negatively regulated | nsubjpass(regulated, expression); advmod(regulated, negatively) | negative regulation of gene expression | INO_0000039 | 2 | In the mother cell compartment of sporulating cells, expression of the [PROTEIN2] sigE [/PROTEIN2] gene, encoding the earlier-acting sigma factor, sigmaE, is negatively regulated by the later-acting sigma factor, [PROTEIN1] sigmaK [/PROTEIN1]. |
43 | FtsZ | SpoIIE | depends | ONE WORD | regulation | INO_0000157 | 1 | The first stage, which involves the phosphatase function of [PROTEIN2] SpoIIE [/PROTEIN2], depends on the cell division protein [PROTEIN1] FtsZ [/PROTEIN1] and could correspond to the FtsZ-dependent assembly of SpoIIE into E-rings. |
44 | FtsZ | SpoIIE | dependent, assembly | amod(assembly, FtsZ-dependent) | regulation of assembly | INO_0000100 | 2 | The first stage, which involves the phosphatase function of [PROTEIN2] SpoIIE [/PROTEIN2], depends on the cell division protein [PROTEIN1] FtsZ [/PROTEIN1] and could correspond to the FtsZ-dependent assembly of SpoIIE into E-rings. |
45 | SpoIIE | SpoIIAA | blocks | ONE WORD | inhibition | INO_0000124 | 1 | Evidence based on the use of modified and mutant forms of the phosphatase protein indicates that [PROTEIN1] SpoIIE [/PROTEIN1] blocks the capacity of unphosphorylated [PROTEIN2] SpoIIAA [/PROTEIN2] to activate sigmaF until formation of the polar septum is completed. |
46 | SpoIIAA | sigmaF | activate | ONE WORD | activation | INO_0000024 | 1 | Evidence based on the use of modified and mutant forms of the phosphatase protein indicates that SpoIIE blocks the capacity of unphosphorylated [PROTEIN1] SpoIIAA [/PROTEIN1] to activate [PROTEIN2] sigmaF [/PROTEIN2] until formation of the polar septum is completed. |
47 | SpoIIE | sigmaF | activation, requires | nsubj(requires, activation)
| regulation of gene activation | INO_0000037 | 2 | Cell-specific activation of transcription factor [PROTEIN2] sigmaF [/PROTEIN2]during sporulation in Bacillus subtilis requires the formation of the polar septum and the activity of a serine phosphatase ([PROTEIN1] SpoIIE [/PROTEIN1]) located in the septum. |
48 | SpoIIE | SpoIIAA-P | dephosphorylating | ONE WORD | dephosphorylation reaction | MI:0203 | 1 | The [PROTEIN1] SpoIIE [/PROTEIN1] phosphatase indirectly activates sigmaF by dephosphorylating a protein ([PROTEIN2] SpoIIAA-P [/PROTEIN2]) in the pathway that controls the activity of the transcription factor. |
49 | SpoIIE | sigmaF | activates | ONE WORD | activation | INO_0000024 | 1 | The [PROTEIN1] SpoIIE [/PROTEIN1] phosphatase indirectly activates [PROTEIN2] sigmaF [/PROTEIN2] by dephosphorylating a protein (SpoIIAA-P) in the pathway that controls the activity of the transcription factor. |
50 | SpoIIAA-P | sigmaF | controls, activity | dobj(controls, activity) | regulation of protein activity | INO_0000055 | 2 | The SpoIIE phosphatase indirectly activates [PROTEIN2] sigmaF [/PROTEIN2] by dephosphorylating a protein ([PROTEIN1] SpoIIAA-P [/PROTEIN1]) in the pathway that controls the activity of the transcription factor. |
52 | sigmaB | bmrUR | control | ONE WORD | controling | INO_0000057 | 1 | (i) The finding that the [PROTEIN2] bmrUR [/PROTEIN2] operon is under [PROTEIN1] sigmaB [/PROTEIN1] control indicates that the elimination of multidrug compounds might be a new function in multiple stress resistance. |
53 | sigmaB | ydaP | dependent | ONE WORD | gene expression regulation | INO_0000044 | 1 | The [PROTEIN1] ydaP [/PROTEIN1] gene might belong to the increasing number of [PROTEIN2] sigmaB [/PROTEIN2]-dependent genes whose orthologues are under the control of sigmas in Escherichia coli, indicating that both regulons may fulfil similar functions. |
54 | sigmaB | ydaE | dependent | ONE WORD | gene expression regulation | INO_0000044 | 1 | Three new [PROTEIN1] sigmaB [/PROTEIN1]-dependent genes ([PROTEIN2] ydaE [/PROTEIN2], ydaG and yfkM) encoding proteins with still unknown functions were also described. |
56 | sigmaB | yfkM | dependent | ONE WORD | gene expression regulation | INO_0000044 | 1 | Three new [PROTEIN1] sigmaB [/PROTEIN1]-dependent genes (ydaE, ydaG and [PROTEIN2] yfkM [/PROTEIN2]) encoding proteins with still unknown functions were also described. |
57 | SpoIIE | sigma F | activated, action | nmod:through(activated, action) | gene activation | INO_0000075 | 2 | Cell specificity is first established in the forespore under the control of the [PROTEIN2] sigma F [/PROTEIN2] factor, which is itself activated through the action of the [PROTEIN1] SpoIIE [/PROTEIN1] serine phosphatase, an enzyme targeted to the septum between the two cells. |
58 | sigmaK | cot | transcribed | ONE WORD | gene transcription | INO_0000173 | 1 | Most [PROTEIN1] cot [/PROTEIN1] genes, and the gerE gene, are transcribed by [PROTEIN2] sigmaK [/PROTEIN2] RNA polymerase. |
59 | sigmaK | gerE | transcribed | ONE WORD | gene transcription | INO_0000173 | 1 | Most cot genes, and the [PROTEIN1] gerE [/PROTEIN1] gene, are transcribed by [PROTEIN2] sigmaK [/PROTEIN2] RNA polymerase. |
60 | GerE | sigK | inhibits, transcription | dobj(inhibits, transcription) | inhibition of gene transcription | INO_0000046 | 2 | Previously, it was shown that the [PROTEIN1] GerE [/PROTEIN1] protein inhibits transcription in vitro of the [PROTEIN2] sigK [/PROTEIN2] gene encoding sigmaK. |
61 | sigmaK | gerE | dependent, transcription | amod(transcription-6, sigmaK-dependent-5) | regulation of transcription | INO_0000032 | 2 | These results demonstrate that [PROTEIN1] sigmaK [/PROTEIN1]-dependent transcription of [PROTEIN2] gerE [/PROTEIN2] initiates a negative feedback loop in which GerE acts as a repressor to limit production of sigmaK. |
62 | GerE | sigmaK | repressor, limit production | acl(repressor, limit); dobj(limit, production)
| inhibition of gene transcription | INO_0000046 | 2 | These results demonstrate that sigmaK-dependent transcription of gerE initiates a negative feedback loop in which [PROTEIN1] GerE [/PROTEIN1] acts as a repressor to limit production of [PROTEIN2] sigmaK [/PROTEIN1]. |
63 | GerE | sigmaK | activated, transcription | dobj(activated, transcription) | regulation of transcription | INO_0000032 | 2 | A low level of [PROTEIN1] GerE [/PROTEIN1] activated transcription of cotD by [PROTEIN2] sigmaK [/PROTEIN2] RNA polymerase in vitro, but a higher level of GerE repressed cotD transcription. |
64 | GerE | cotD | low level, activated, transcription | MORE THAN TWO KEYWORDS | activation of gene transcription by low level protein | INO_0000052 | 3 | A low level of GerE activated transcription of cotD by sigmaK RNA polymerase in vitro, but a higher level of [PROTEIN1] GerE [/PROTEIN1] repressed [PROTEIN2] cotD [/PROTEIN2] transcription. |
65 | sigmaK | cotD | transcription | ONE WORD | regulation of transcription | INO_0000032 | 1 | A low level of GerE activated transcription of [PROTEIN2] cotD [/PROTEIN2] by [PROTEIN1] sigmaK [/PROTEIN1] RNA polymerase in vitro, but a higher level of GerE repressed cotD transcription. |
67 | GerE | sigK | binds, transcriptional, act, repressor | MORE THAN TWO KEYWORDS | negative regulation of gene transcription | INO_0000042 | 4 | Here, we show that [PROTEIN1] GerE [/PROTEIN1] binds near the [PROTEIN2] sigK [/PROTEIN2] transcriptional start site, to act as a repressor. |
68 | GerE | cotD | binds, promoter | -1 | regulation of transcription by binding to promoter | INO_0000071 | 2 | We show that [PROTEIN1] GerE [/PROTEIN1] binds to two sites that span the -35 region of the [PROTEIN2] cotD [/PROTEIN2] promoter. |
69 | GerE | cotD | activate, transcription, repress, transcription | dobj(activate, transcription); advmod(transcription, repress) | regulation of transcription | INO_0000032 | 2 (2 events with two keywords each) | These results suggest that a rising level of [PROTEIN1] GerE [/PROTEIN1] in sporulating cells may first activate [PROTEIN2] cotD [/PROTEIN2] transcription from the upstream site then repress transcription as the downstream site becomes occupied. |
70 | GerE | sspG | transcription, requires | nsubj(requires,transcription);
| regulation of transcription | INO_0000032 | 2 | [PROTEIN2] sspG [/PROTEIN2] transcription also requires the DNA binding protein [PROTEIN1] GerE [/PROTEIN1]. |
71 | sigmaG | sspJ | transcribed | ONE WORD | gene transcription | INO_0000173 | 1 | In contrast, [PROTEIN1] sspJ [/PROTEIN1] is transcribed in the forespore compartment by RNA polymerase with the forespore-specific [PROTEIN2] sigmaG [/PROTEIN2] and appears to give a monocistronic transcript. |
72 | ComK | FlgM | stimulating, transcription | dobj(stimulating,transcription) | positive regulation of gene transcription | INO_0000049 | 2 | [PROTEIN1] ComK [/PROTEIN1] negatively controls the transcription of hag by stimulating the transcription of comF-flgM, thereby increasing the production of the [PROTEIN2] FlgM [/PROTEIN2] antisigma factor that inhibits sigmaD activity. |
73 | ComK | hag | negatively controls, transcription | dobj(controls, transcription); advmod(controls, negatively) | negative regulation of gene transcription | INO_0000042 | 2 | [PROTEIN1] ComK [/PROTEIN1] negatively controls the transcription of [PROTEIN2] hag [/PROTEIN2] by stimulating the transcription of comF-flgM, thereby increasing the production of the FlgM antisigma factor that inhibits sigmaD activity. |
74 | ComK | comF | stimulating, transcription | dobj(stimulating,transcription) | positive regulation of gene transcription | INO_0000049 | 2 | [PROTEIN1] ComK [/PROTEIN1] negatively controls the transcription of hag by stimulating the transcription of [PROTEIN2] comF [/PROTEIN2]-flgM, thereby increasing the production of the FlgM antisigma factor that inhibits sigmaD activity. |
76 | FlgM | sigmaD | inhibit, activity | dobj(inhibits,activity) | inhibition of protein activity | INO_0000070 | 2 | ComK negatively controls the transcription of hag by stimulating the transcription of comF-flgM, thereby increasing the production of the [PROTEIN1] FlgM [/PROTEIN1] antisigma factor that inhibits [PROTEIN2] sigmaD [/PROTEIN2] activity. |
77 | sigmaB | ykzA | increase, expression, dependent | MORE THAN TWO KEYWORDS | positive regulation of gene expression | INO_0000038 | 3 | This stress-induced increase in [PROTEIN2] ykzA [/PROTEIN2] expression is absolutely dependent on the alternative sigma factor [PROTEIN1] sigmaB [/PROTEIN1], which controls a large stationary-phase and stress regulon. |
78 | sigma X | CsbB | contributes, expression | nmod(contributes,expression) | gene expression regulation | INO_0000044 | 2 | [PROTEIN1] sigma X [/PROTEIN1] also contributes to the expression of [PROTEIN2] CsbB [/PROTEIN2], a putative membrane-bound glucosyl transferase that is partially controlled by the sigma B stress response sigma factor. |
79 | sigma B | CsbB | controlled | ONE WORD | controling | INO_0000057 | 1 | sigma X also contributes to the expression of [PROTEIN2] CsbB [/PROTEIN2], a putative membrane-bound glucosyl transferase that is partially controlled by the [PROTEIN1] sigma B [/PROTEIN1] stress response sigma factor. |
80 | sigma B | nadE | induced, dependent | -1 | positive regulation of gene expression | INO_0000038 | 2 | Transcriptional studies showed that [PROTEIN2] nadE [/PROTEIN2] is strongly induced in response to heat, ethanol and salt stress or after starvation for glucose in a [PROTEIN1] sigma B [/PROTEIN1]-dependent manner. |
81 | sigma(B) | YtxH | induced, dependent | -1 | positive regulation of gene expression | INO_0000038 | 2 | Furthermore, [PROTEIN2] YtxH [/PROTEIN2] and YvyD seemed to be induced after phosphate starvation in the wild type in a [PROTEIN1] sigma(B) [/PROTEIN1]-dependent manner and in the sigB mutant probably via sigma(H). |
82 | sigma(B) | YvyD | induced, dependent | -1 | positive regulation of gene expression | INO_0000038 | 2 | Furthermore, YtxH and [PROTEIN1] YvyD [/PROTEIN1] seemed to be induced after phosphate starvation in the wild type in a [PROTEIN2] sigma(B) [/PROTEIN2]-dependent manner and in the sigB mutant probably via sigma(H). |
83 | sigma(H) | YtxH | induced, via | -1 | induction | INO_0000122 | 2 | Furthermore, [PROTEIN1] YtxH [/PROTEIN1] and YvyD seemed to be induced after phosphate starvation in the wild type in a sigma(B)-dependent manner and in the sigB mutant probably via [PROTEIN2] sigma(H) [/PROTEIN2]. |
84 | sigma(H) | YvyD | induced, via | -1 | induction | INO_0000122 | 2 | Furthermore, YtxH and [PROTEIN2] YvyD [/PROTEIN2] seemed to be induced after phosphate starvation in the wild type in a sigma(B)-dependent manner and in the sigB mutant probably via [PROTEIN1] sigma(H) [/PROTEIN1]. |
86 | ComK | sigmaD | preventing, transcription | dobj(preventing,transcription) | inhibition of gene transcription | INO_0000046 | 2 | From these results we conclude that [PROTEIN1] ComK [/PROTEIN1] negatively regulates degR expression by preventing [PROTEIN2] sigmaD [/PROTEIN2]-driven transcription of degR, possibly through interaction with the control region. |
87 | ComK | degR | negatively regulates, expression | dobj(regulates,expression) | negative regulation of gene expression | INO_0000039 | 2 | From these results we conclude that [PROTEIN1] ComK [/PROTEIN1] negatively regulates [PROTEIN2] degR [/PROTEIN2] expression by preventing sigmaD-driven transcription of degR, possibly through interaction with the control region. |
88 | ComK | degR | preventing, transcription | dobj(preventing,transcription) | inhibition of gene transcription | INO_0000046 | 2 | From these results we conclude that [PROTEIN1] ComK [/PROTEIN1] negatively regulates [PROTEIN2] degR [/PROTEIN2] expression by preventing sigmaD-driven transcription of degR, possibly through interaction with the control region. |
89 | sigmaD | degR | driven, transcription | amod(transcription, sigmaD-driven) | positive regulation of gene transcription | INO_0000049 | 2 | From these results we conclude that ComK negatively regulates degR expression by preventing [PROTEIN1] sigmaD [/PROTEIN1]-driven transcription of [PROTEIN2] degR [/PROTEIN2], possibly through interaction with the control region. |
90 | sigmaD | degR | transcription, driven | nsubjpass(driven,transcription) | positive regulation of gene transcription | INO_0000049 | 2 | We have shown previously that the transcription of [PROTEIN2] degR [/PROTEIN2] is driven by an alternative sigma factor, [PROTEIN1] sigmaD [/PROTEIN1]. |
91 | SpoIIID | cotC | binds | ONE WORD | direct interaction | MI_0407 | 1 | DNase I footprinting showed that [PROTEIN1] SpoIIID [/PROTEIN1] binds strongly to two sites in the [PROTEIN2] cotC [/PROTEIN2] promoter region, binds weakly to one site in the cotX promoter, and does not bind specifically to cotB. |
92 | SpoIIID | cotX | binds | ONE WORD | direct interaction | MI_0407 | 1 | DNase I footprinting showed that [PROTEIN1] SpoIIID [/PROTEIN1] binds strongly to two sites in the cotC promoter region, binds weakly to one site in the [PROTEIN2] cotX [/PROTEIN2] promoter, and does not bind specifically to cotB. |
93 | SpoIIID | cotB | bind | ONE WORD | direct interaction | MI_0407 | 1 | DNase I footprinting showed that [PROTEIN1] SpoIIID [/PROTEIN1] binds strongly to two sites in the cotC promoter region, binds weakly to one site in the cotX promoter, and does not bind specifically to [PROTEIN2] cotB [/PROTEIN2]. |
94 | sigma(K) | cotB | transcription | ONE WORD | gene transcription | INO_0000173 | 1 | Transcription of the [PROTEIN1] cotB [/PROTEIN1], cotC, and cotX genes by final [PROTEIN2] sigma(K) [/PROTEIN2] RNA polymerase is activated by a small, DNA-binding protein called GerE. |
96 | sigma(K) | cotX | transcription | ONE WORD | gene transcription | INO_0000173 | 1 | Transcription of the cotB, cotC, and [PROTEIN1] cotX [/PROTEIN1] genes by final [PROTEIN2] sigma(K) [/PROTEIN2] RNA polymerase is activated by a small, DNA-binding protein called GerE. |
97 | GerE | cotB | transcription, activated | nsubjpass(activated,transcription) | activation of gene transcription | INO_0000051 | 2 | Transcription of the [PROTEIN2] cotB [/PROTEIN2], cotC, and cotX genes by final sigma(K) RNA polymerase is activated by a small, DNA-binding protein called [PROTEIN1] GerE [/PROTEIN1]. |
98 | GerE | cotC | transcription ,activated | nsubjpass(activated,transcription) | activation of gene transcription | INO_0000051 | 2 | Transcription of the cotB, [PROTEIN2] cotC [/PROTEIN2], and cotX genes by final sigma(K) RNA polymerase is activated by a small, DNA-binding protein called [PROTEIN1] GerE [/PROTEIN1]. |
99 | GerE | cotX | transcription, activated | nsubjpass(activated,transcription) | activation of gene transcription | INO_0000051 | 2 | Transcription of the cotB, cotC, and [PROTEIN2] cotX [/PROTEIN2] genes by final sigma(K) RNA polymerase is activated by a small, DNA-binding protein called [PROTEIN1] GerE [/PROTEIN1]. |
100 | GerE | cot | gene expression, action | -1 | gene expression regulation | INO_0000044 | 2 | In vitro transcription experiments suggest that the differential pattern of [PROTEIN2] cot [/PROTEIN2] gene expression results from the combined action of [PROTEIN1] GerE [/PROTEIN1] and another transcription factor, SpoIIID. |
102 | GerE | sigma(K) | low concentration, activated, transcription | MORE THAN TWO KEYWORDS | regulation of transcription | INO_0000032 | 3 | A low concentration of [PROTEIN1] GerE [/PROTEIN1] activated cotB transcription by final [PROTEIN2] sigma(K) [/PROTEIN2] RNA polymerase, whereas a higher concentration was needed to activate transcription of cotX or cotC. |
103 | GerE | cotB | low concentration, activated, transcription | MORE THAN TWO KEYWORDS | activation of gene transcription by low level protein | INO_0000052 | 3 | A low concentration of [PROTEIN1] GerE [/PROTEIN1] activated [PROTEIN2] cotB [/PROTEIN2] transcription by final sigma(K) RNA polymerase, whereas a higher concentration was needed to activate transcription of cotX or cotC. |
104 | GerE | cotX | activate, transcription | amod(transcription, activate) | activation of gene transcription | INO_0000051 | 2 | A low concentration of [PROTEIN1] GerE [/PROTEIN1] activated cotB transcription by final sigma(K) RNA polymerase, whereas a higher concentration was needed to activate transcription of [PROTEIN2] cotX [/PROTEIN2] or cotC. |
106 | sigma(K) | cotB | activated, transcription | dobj(activated,transcription) | activation of gene transcription | INO_0000051 | 2 | A low concentration of GerE activated [PROTEIN2] cotB [/PROTEIN2] transcription by final [PROTEIN1] sigma(K) [/PROTEIN1] RNA polymerase, whereas a higher concentration was needed to activate transcription of cotX or cotC. |
107 | SpoIIID | cotC | repressed, transcription | dobj(repressed,transcription) | inhibition of gene transcription | INO_0000046 | 2 | [PROTEIN1] SpoIIID [/PROTEIN1] at low concentration repressed [PROTEIN2] cotC [/PROTEIN2] transcription, whereas a higher concentration only partially repressed cotX transcription and had little effect on cotB transcription. |
108 | SpoIIID | cotX | repressed, transcription | dobj(repressed,transcription) | inhibition of gene transcription | INO_0000046 | 2 | [PROTEIN1] SpoIIID [/PROTEIN1] at low concentration repressed cotC transcription, whereas a higher concentration only partially repressed [PROTEIN2] cotX [/PROTEIN2] transcription and had little effect on cotB transcription. |
109 | SpoIIID | cotB | repressed, transcription | dobj(repressed,transcription) | inhibition of gene transcription | INO_0000046 | 2 | [PROTEIN1] SpoIIID [/PROTEIN1] at low concentration repressed cotC transcription, whereas a higher concentration only partially repressed cotX transcription and had little effect on [PROTEIN2] cotB [/PROTEIN2] transcription. |
110 | sigmaA | kdgR | dependent, promoter | amod(promoter, sigmaA-dependent) | promoter-based regulation of transcription | INO_0000079 | 2 | Primer extension experiments and Northern blot analysis show that an active [PROTEIN1] sigmaA [/PROTEIN1]-dependent promoter precedes [PROTEIN2] kdgR [/PROTEIN2] and transcription is terminated at the putative p-independent terminator downstream of kdgT. |
111 | sigmaW | sigW | dependent, promoter, precedes | MORE THAN TWO KEYWORDS | promoter-based regulation of transcription | INO_0000079 | 3 | A [PROTEIN1] sigmaW [/PROTEIN1]-dependent promoter (PW) precedes [PROTEIN2] sigW [/PROTEIN2], demonstrating that this transcription factor is positively autoregulated. |
112 | sigma(A) | sigX | recognize, promoter | -1 | promoter-based regulation of transcription | INO_0000079 | 2 | We overproduced and purified sigma(X) from Escherichia coli and demonstrate that in vitro, both [PROTEIN1] sigma(A) [/PROTEIN1] and sigma(X) holoenzymes recognize promoter elements within the [PROTEIN2] sigX [/PROTEIN2]-ypuN control region. |
113 | sigma(A) | ypuN | recognize, promoter | -1 | promoter-based regulation of transcription | INO_0000079 | 2 | We overproduced and purified sigma(X) from Escherichia coli and demonstrate that in vitro, both [PROTEIN1] sigma(A) [/PROTEIN1] and sigma(X) holoenzymes recognize promoter elements within the sigX-[PROTEIN2] ypuN [/PROTEIN2] control region. |
114 | sigma(X) | sigX | recognize, promoter | -1 | promoter-based regulation of transcription | INO_0000079 | 2 | We overproduced and purified [PROTEIN1] sigma(X) [/PROTEIN1] from Escherichia coli and demonstrate that in vitro, both sigma(A) and sigma(X) holoenzymes recognize promoter elements within the [PROTEIN2] sigX [/PROTEIN2]-ypuN control region. |
116 | PhoP~P | tagA | repress, transcription | dobj(repress,transcription) | inhibition of gene transcription | INO_0000046 | 2 | The results indicate that [PROTEIN1] PhoP~P [/PROTEIN1] is sufficient to repress the transcription of the [PROTEIN2] tagA [/PROTEIN2] and tagD promoters and also to activate the transcription of the tuaA promoter. |
117 | PhoP~P | tagD | repress, transcription | dobj(repress,transcription) | inhibition of gene transcription | INO_0000046 | 2 | The results indicate that [PROTEIN1] PhoP~P [/PROTEIN1] is sufficient to repress the transcription of the tagA and [PROTEIN2] tagD [/PROTEIN2] promoters and also to activate the transcription of the tuaA promoter. |
118 | PhoP~P | tuaA | activate, transcription | dobj(activate,transcription) | activation of gene transcription | INO_0000051 | 2 | The results indicate that [PROTEIN1] PhoP~P [/PROTEIN1] is sufficient to repress the transcription of the tagA and tagD promoters and also to activate the transcription of the [PROTEIN2] tuaA [/PROTEIN2] promoter. |