text: Altered cholesterol homeostasis in aged macrophages linked to neovascular macular degeneration.
  Abnormal lipid metabolism has been linked to age-related macular degeneration (AMD); choroidal neovascularization in late AMD commonly causes blindness. Sene et al. (2013) now demonstrate that in aged macrophages decreased ABCA1 expression, regulated by liver X receptor and miR-33, impairs export of intracellular cholesterol, which promotes neovascular AMD.
entities.id: T1 T2 T3 T4 T5
entities.type: CHEMICAL CHEMICAL GENE-Y GENE-N GENE-N
entities.text: cholesterol cholesterol ABCA1 liver X receptor miR-33