passages.id: split_4_test_1517_passage
passages.type: progene_text
passages.text: Endothelial dysfunction in patients suffering from atherosclerosis or diabetes type 2 is associated not only with suppression in release of the above mediators but also with deleterious discharge of prostaglandin endoperoxides ( PGH2 , PGG2 ) , superoxide anion ( O2 - , peroxynitrite ( ONOO-) , and plasminogen activator inhibitor ( PAI-1 ) . We looked for mechanisms of protective endothelial function , with a special respect to the differences between peripheral and pulmonary circulation. METHODS : Cultured endothelial cells of bovine aorta ( BAEC ) were used to study physiological and pharmacological mechanisms of increasing free cytoplasmic calcium [Ca2+]i .