passages.id: split_4_test_1058_passage
passages.type: progene_text
passages.text: The molecules of the interleukin 1 ( IL-1 ) system have been suggested to play a role in the pathogenesis of insulin - dependent diabetes mellitus ( IDDM ) , and polymorphisms in the genes encoding IL-1beta ( IL1B ) , the IL-1 Type 1 receptor ( IL1RTI ) and the IL-1 receptor antagonist ( IL1RN ) molecules have been associated with IDDM in case - control studies .