passages.id: split_4_test_1798_passage
passages.type: progene_text
passages.text: The main effect of the ectopic Cdk6 expression was to sequester TGF-beta induced p15 ( Ink4b ) and to maintain more p27 ( Kip1 ) in cyclin D - complexes preventing the complete shift of p27 ( Kip1 ) to Cdk2 invoked by TGF-beta .