passages.id: split_4_test_3269_passage
passages.type: progene_text
passages.text: Immunomodulatory drugs ( IMiDs ) are orally available small molecules that potently inhibit tumor necrosis factor - alpha ( TNF-alpha ) production by lipopolysaccharide ( LPS ) - stimulated human peripheral blood mononuclear cells ( HuPBMCs ) but enhance secretion of such cytokines as interleukin-2 ( IL-2 ) and interferon-gamma ( IFN-gamma ) by stimulated T cells .