passages.id: split_4_test_3273_passage
passages.type: progene_text
passages.text: In T cells stimulated with phorbol myristate acetate ( PMA ) / ionomycin , CC-4047 enhanced the DNA - binding activity of activated protein-1 ( AP-1 ) but not NF-kappaB , Octomer-1 ( OCT-1 ) , or NFAT by 2 - fold and 4 - fold after an incubation time of 1 and 3 h , respectively .