passages.id: split_4_test_2751_passage
passages.type: progene_text
passages.text: Although no common polymorphisms could be identified in the IL-12R beta 2 gene ( IL-12RB2 ) , we confirmed four single nucleotide polymorphisms ( SNPs ; 641A --> G , 684C --> T , 1094T --> C , and 1132G --> C ) causing three missense variants ( Q214R , M365T , G378R ) and one synonymous substitution in the extracellular domain of the IL-12R beta 1 gene ( IL12RB1 ) .