passages.id: split_4_test_2679_passage
passages.type: progene_text
passages.text: Both T-cell depletion and the neoplastic phenotype of Cul1 - N252 Tg mice are largely rescued in Cul1 - N252 , Skp1 double - Tg mice , indicating that the effects of Cul1 - N252 are due to a sequestration of the endogenous Skp1 .