passages.id: split_4_test_1801_passage
passages.type: progene_text
passages.text: The results demonstrate that downregulation of Cdk6 kinase is required for the enforcement of the G(1) - phase arrest by TGF-beta and results in changes in association of the p15 ( Ink4b ) and p27 ( Kip1 ) inhibitors with D - and E - type cyclin kinase complexes .