passages.id: split_4_test_1104_passage
passages.type: progene_text
passages.text: To evaluate whether polymorphisms in genes whose products are involved in lipid metabolism and fibrinolysis alter the risk of coronary artery disease ( CAD ) , allele frequencies of four genetic polymorphisms were ascertained by PCR - based methods in 175 Czech male patients with coronary artery disease and in 222 Czech men with no symptoms of CAD .