passages.id: split_4_test_1653_passage
passages.type: progene_text
passages.text: However , two isoenzymes of 11 beta-hydroxysteroid dehydrogenase ( 11 beta HSD ) , either by converting cortisone ( E ) to cortisol ( F ) ( type 1 ) or conversely by converting F to E ( type 2 ) , play an important prereceptor role in regulating corticosteroid hormone action at several sites .