passages.id: split_4_test_686_passage
passages.type: progene_text
passages.text: The analysis of two distinct mitogen - activated protein kinase pathways shows that stress - activated protein kinase - Jun N - terminal kinase activation , resulting in the phosphorylation of ATF-2 , c-Jun , and JunD , is required not only for the IL-1 - but also for the TPA - dependent induction , while the extracellular signal - related kinase 1 ( ERK-1 ) and ERK-2 activation is involved in the TPA - but not in the IL-1 - dependent stimulation of the uPA enhancer .