passages.id: split_4_test_2941_passage
passages.type: progene_text
passages.text: Although there existed extensive metabolizers and poor metabolizers in Sprague - Dawley rats administrated 6,7-dimethoxyquinazoline derivatives ( 1b and 1c ) , 6-(2-methoxy ) ethoxy - 7 - methoxyquinazoline analogue 16k showed no metabolic polymorphism .