passages.id: split_4_test_659_passage
passages.type: progene_text
passages.text: The ATII type 1 receptor ( AT1 ) antagonist , Losartan , inhibited ATII - induction of p42 / 44 ERK , as well as Egr-1 and PDGF-A , whereas neither PD123319 , an AT2 receptor antagonist , nor wortmannin , an inhibitor of phosphatidylinositol 3-kinase and c-Jun N - terminal kinase , had any effect .