passages.id: split_4_test_2439_passage
passages.type: progene_text
passages.text: TGF-beta 1 was previously shown to increase p21 protein levels , which in turn mediated G(1) arrest through inactivation of the CDK2 - cyclin E complex in HD3 cells ( Yan , Z. , Kim , G.-Y. , Deng , X. , and Friedman , E. ( 2002 ) J. Biol. Chem. 277 , 9870 - 9879 ) .