passages.id: split_4_test_1271_passage
passages.type: progene_text
passages.text: The transduction of inhibitory signals by KIR2D molecules is impaired by the zinc chelator , 1,10-phenanthroline , and mutation of a putative zinc - binding site ( Rajagopalan , S. , and Long , E. O. ( 1998 ) J. Immunol. 161 , 1299 - 1305 ) , but the mechanism by which zinc may affect the function of KIR remains unknown .