passages.id: split_4_test_2527_passage
passages.type: progene_text
passages.text: Functional studies showed that coexpression of the rat P450scc promoter ( - 378 / + 8 CAT ) and AP-2 isoforms ( alpha or gamma ) in human embryonic kidney 293 cells results in a marked activation of chloramphenicol acetyltransferase ( CAT ) transcription that is dependent on an intact AP-2 motif , GCCTTGAGC .