passages.id: split_4_test_221_passage
passages.type: progene_text
passages.text: Both mutants could trans-activate on a PPRE from the P450 cytochrome promoter CYP4A1 , whereas only the hPPAR alpha - L391R mutant could trans-activate from the acyl-CoA oxidase PPRE ( ACOA ) and , when stimulated with the peroxisome proliferator Wy14643 , also from the bifunctional enzyme PPRE .