passages.id: split_4_test_1796_passage
passages.type: progene_text
passages.text: Transforming growth factor - beta ( TGF-beta ) induced growth arrest of cells involves regulation of the activities of both D - and E - type cyclin kinase complexes thought to be mediated primarily by the regulation of p15 ( Ink4b ) and p27 ( Kip1 ) cyclin kinase inhibitors .