passages.id: split_4_test_2754_passage
passages.type: progene_text
passages.text: In our case - control association study of tuberculosis , the R214 - T365 - R378 allele ( allele 2 ) was over - represented in patients with tuberculosis , and homozygosity for R214 - T365 - R378 ( the 2/2 genotype ) was significantly associated with tuberculosis ( odds ratio : 2.45 ; 95 % CI : 1.20 - 4.99 ; P = 0.013 ) .