passages.id: split_4_test_216_passage
passages.type: progene_text
passages.text: We have previously reported that replacement of a single leucine by an arginine at position 433 of hPPAR alpha ( L433R ) , located in a highly conserved region of the ninth heptad repeat of a leucine - zipper - like motif in the ligand binding domain , abolished heterodimerization of PPAR with RXR and hence its trans - activating capacity .