passages.id: split_4_test_2536_passage
passages.type: progene_text
passages.text: High concentrations of PPARgamma ligands were shown to have anti - inflammatory activities by inhibiting the secretion of interleukin-1 ( IL-1 ) , interleukin-6 ( IL-6 ) and tumour necrosis factor alpha ( TNFalpha ) by stimulated monocytes.The aim of this study was to determine whether PGJ2 and TZDs would also exert an immunomodulatory action through the up - regulation of anti - inflammatory cytokines such as the IL-1 receptor antagonist ( IL-1Ra ) .