passages.id: split_4_test_682_passage
passages.type: progene_text
passages.text: We have investigated the in vivo and in vitro regulation of the human urokinase - type plasminogen activator ( uPA ) gene by interleukin-1 ( IL-1 ) and analyzed the transcription factors and signalling pathways involved in the response of the - 2.0 - kb uPA enhancer to IL-1 induction and to tetradecanoyl phorbol acetate ( TPA ) induction .