passages.id: split_4_test_1431_passage
passages.type: progene_text
passages.text: Expression of the MAP kinase kinase kinase ( MAPKKK ) TAK1 together with its coactivator TAB1 in HeLa cells activated all three pathways and was sufficient to induce IL-8 formation , NF-kappaB + JNK2 - mediated transcription from a minimal IL-8 promoter , and p38 MAPK - mediated stabilization of a reporter mRNA containing IL-8 - derived regulatory mRNA sequences .