passages.id: split_7_validation_1677_passage
passages.type: progene_text
passages.text: The mechanism for the accelerated and increased mobilization to the spleen by the PG - formulation of G-CSF is due , in part , to its increased bioavailability ( > 1.5 - fold ) , T(max) ( 6 - fold ) , and prolonged elimination ( Tbeta ) half - life ( > 3 - fold ) as compared with a saline formulation .