passages.id: split_7_validation_422_passage
passages.type: progene_text
passages.text: In our studies , the ligation of Fg to ICAM-1 on tumor necrosis factor-alpha - stimulated endothelial cells resulted in the tyrosine phosphorylation of Src homology domain 2 ( SH2 ) - containing phosphatase-2 ( SHP-2 ) .