passages.id: split_7_validation_1353_passage
passages.type: progene_text
passages.text: Interestingly , although both PtdIns-(3,4,5)P3 and PtdIns(3,4) P2 have been implicated in the regulation of Akt activity in vitro , overexpression of SHIP2 inhibited insulin - induced Akt activation , presumably by its 5'-inositol phosphatase activity .