passages.id: split_9_validation_981_passage
passages.type: progene_text
passages.text: A redundant reactivity of many GAD65 - ab positive sera to three major conformational ( EP-1 , EP-2 , EP-3 ) and two dominant linear epitope clusters ( amino acid 1 - 124 and 535 - 585 ) was observed in diabetes , polyendocrine autoimmune syndrome and stiff - man syndrome and no disease - specific epitopes or epitope - profiles were detected .