passages.id: split_9_validation_1365_passage
passages.type: progene_text
passages.text: The regulatory domains in each Ras exchanger mediate the signals arriving from upstream elements such as tyrosine kinases for Sos , or Ca2+ and G proteins for p140.(Ras-GRF ) In this study , we show that the N-terminal half ( NTH ) of S. cerevisiae Cdc25 , as well as the C - terminal 37 amino acids , is essential for processing the elevation of cAMP in response to glucose .