passages.id: split_9_validation_1576_passage
passages.type: progene_text
passages.text: Targeted deletion of the gene encoding murine CXCR2 does not result in obvious changes in the development of the organ system of the mouse , though the CXCR2 -/- mouse is compromised with regard to its ability to resist infection , heal wounds , and maintain homeostasis when challenged with microbes and/or chemicals .