passages.id: split_9_validation_1451_passage
passages.type: progene_text
passages.text: In this study , we report that molecules released by CD8 ( + ) CD28 ( - ) T lymphocytes from HIV-1 - infected patients promote endothelial - cell ( EC ) growth and induce ECs to acquire spindle cell morphology and upregulation of intercellular adhesion molecule-1 ( ICAM-1 ) , E-selectin , and vascular endothelial cell growth factor receptor-3 ( VEGFR-3 ) ( a typical feature of the KS cell phenotype ) .