News Finding: Depending on the Wnt activity, the cancer cells can switch back and forth between the stem cell state and a differentiated state.
Paper Finding: Treatment of intestinal organoids from wild-type C57BL/6 mice with trametinib resulted in a significant induction of LGR5 and ASCL2 expression at 10 and 100 nM (Fig.
News Context: The researchers thus provide a possible explanation for why these drugs are not effective in colorectal cancer. Depending on the Wnt activity, the cancer cells can switch back and forth between the stem cell state and a differentiated state. At the same time, the gene activity of the cancer cells changed to a stem cell-typical pattern.
Paper Context: 6b) , and of LGR5, BIRC5, CCDN1 (Fig. Treatment of intestinal organoids from wild-type C57BL/6 mice with trametinib resulted in a significant induction of LGR5 and ASCL2 expression at 10 and 100 nM (Fig. Compared to the wild-type counterpart, the APC-KRAS line showed an increased basal expression level of AXIN2 and the intestinal stemness marker ASCL2 30 .