News Finding: And, he noted, since sleep is important for encoding memories and consolidating learning, this hyperexcitability of brain networks in FXS may interfere with the process of laying down new memories, and perhaps explain the learning disability in children with FXS.
Paper Finding: However, when we examined only EEG epochs with L/H power > 200, which others have used as an arbitrary cut-off that represents slow-wave sleep , we found that Fmr1 −/− mice had higher firing rates (Fmr1 −/− , 0.27 ± 0.017 Hz, n = 5 recordings; wild type, 0.22 ± 0.0096 Hz, n = 6 recordings; P = 0.023, t test; Fig.
News Context: "Interestingly, we found that the high firing and synchrony were especially apparent at times when the animals were asleep. And, he noted, since sleep is important for encoding memories and consolidating learning, this hyperexcitability of brain networks in FXS may interfere with the process of laying down new memories, and perhaps explain the learning disability in children with FXS. Hopefully, this may be helpful to treat symptoms of FXS," he said.
Paper Context: Pair-wise correlation coefficients (as determined from calcium traces, 100 µm distance between pairs) showed a nearly significant trend toward higher synchrony with higher L/H power in Fmr1 −/− mice at P14-16, but not in wild-type mice (Fmr1 −/− , r 2 = 0.347, n = 10 recordings, P = 0.073; wild type, r 2 = 0.027, n = 13 recordings, P = 0.649; F test; Fig. However, when we examined only EEG epochs with L/H power > 200, which others have used as an arbitrary cut-off that represents slow-wave sleep , we found that Fmr1 −/− mice had higher firing rates (Fmr1 −/− , 0.27 ± 0.017 Hz, n = 5 recordings; wild type, 0.22 ± 0.0096 Hz, n = 6 recordings; P = 0.023, t test; Fig. 5e ) and higher correlation coefficients than wild-type mice (Fmr1 −/− , 0.25 ± 0.014, n = 5 recordings; wild type, 0.20 ± 0.015, n = 6 recordings; P = 0.039, t test; Fig.