News Finding: Depending on the Wnt activity, the cancer cells can switch back and forth between the stem cell state and a differentiated state.
Paper Finding: of selected Wnt and Ras pathway members in trametinib versus DMSO treated cells.
News Context: The researchers thus provide a possible explanation for why these drugs are not effective in colorectal cancer. Depending on the Wnt activity, the cancer cells can switch back and forth between the stem cell state and a differentiated state. At the same time, the gene activity of the cancer cells changed to a stem cell-typical pattern.
Paper Context: Taken together, these results suggest that dual blockage of Wnt and RAS signalling has superior antiproliferative effects in CRC over single inhibition of either pathway. of selected Wnt and Ras pathway members in trametinib versus DMSO treated cells. Mean values of three independent replicates are shown.