News Finding: Molecular basis of #Klotho: from gene to function in aging. 
Paper Finding: The in vivo expression of Klotho decreases the activation of renal ␤-catenin and improves renal fibrosis in chronic kidney disease .
News Context: Molecular basis of #Klotho: from gene to function in aging. 
Paper Context: Klotho may therefore suppress Wnt signaling (Figure 4b ). The in vivo expression of Klotho decreases the activation of renal ␤-catenin and improves renal fibrosis in chronic kidney disease . ␣-Klotho regulates intracellular Ca 2ϩ (Figure 4c ), which in turn increases -calpain activity leading to the degradation of ␤-catenin.