News Finding: It will take much more time than that to prove that the approach is safe to use in humans, though, Gambhir cautioned.
Paper Finding: pSurv-driven plasmids led to significantly higher FLuc activity in MeWo cells (***P < 0.001) and equivalent activity in MDA-MB-231 cells.
News Context: "We haven't got it down to a pill yet, but the oral delivery part of this is likely a solvable problem -- only a few years off, not five or 10 years off." It will take much more time than that to prove that the approach is safe to use in humans, though, Gambhir cautioned. Eventually, he said, he foresees variations, such as adding a second gene to the minicircles.
Paper Context: pPEG-driven plasmids led to significantly higher FLuc activity in fibroblasts than pSurv (*P < 0.05). pSurv-driven plasmids led to significantly higher FLuc activity in MeWo cells (***P < 0.001) and equivalent activity in MDA-MB-231 cells. Significantly higher SEAP activity was observed in the medium of cells transfected with MCs from day 2 to day 7 (**P < 0.01; ***P < 0.001).