News Finding: "The combination of in vitro and in vivo experimental models to understand the biophysical and molecular mechanisms of primary blast injury and the effects of treatment on the BBB offer a powerful set of tools to guide the development of novel therapeutic strategies to mitigate the consequences of bTBI," says Morrison.
Paper Finding: The bTBI model is capable of isolating interactions between the BBB culture and blast overpressure alone, substantially reducing the influence of inertial loading, thereby enabling precise investigation of primary blast injury.
News Context: Morrison and his team are hoping next to translate their in vitro findings in vivo. "The combination of in vitro and in vivo experimental models to understand the biophysical and molecular mechanisms of primary blast injury and the effects of treatment on the BBB offer a powerful set of tools to guide the development of novel therapeutic strategies to mitigate the consequences of bTBI," says Morrison. "Accelerating BBB recovery after blast exposure represents an important advance in addressing the multifaceted, short- and long-term complications associated with bTBI."
Paper Context: These findings hold important implications for development of a potential therapy for restoring BBB integrity and function after bTBI. The bTBI model is capable of isolating interactions between the BBB culture and blast overpressure alone, substantially reducing the influence of inertial loading, thereby enabling precise investigation of primary blast injury. kPa peak incident overpressure, 1.06 ± 0.01 ms duration, and 16 ± 1.5 kPa ms impulse in the open-tube configuration.