News Finding: Going from 2 X's to 1: Mammalian X inactivation relies on stepwise folding of #chromosome compartments aided by SMCHD1  @username @username @username 
Paper Finding: We conclude that SMCHD1 plays a critical role in organizing Xi structures by merging chromatin compartments.
News Context: Going from 2 X's to 1: Mammalian X inactivation relies on stepwise folding of #chromosome compartments aided by SMCHD1  @username @username @username 
Paper Context: SMCHD1 depletion thus revealed a tendency of Xist-rich and Xist-poor chromatin to form distinct spatial compartments, a hidden layer of architectural organization obscured on the normal Xi. We conclude that SMCHD1 plays a critical role in organizing Xi structures by merging chromatin compartments. Interestingly, however, by employing in situ Hi-C, we observed clearly discernible TADs, albeit weak, across the entire Xi of WT NPCs at 40-kb resolution (Figures 5A and S4C) .