News Finding: These results may help to improve the efficacy and safety of neoadjuvant chemotherapy.
Paper Finding: 52) strongly suggests that EV-associated ANXA6 was in fact of cancer cell origin.
News Context: Importantly, the researchers found that neutralizing annexin-A6 or blocking monocytes during chemotherapy prevents the experimental mammary tumors from metastasizing to the lung. These results may help to improve the efficacy and safety of neoadjuvant chemotherapy. "Our findings must not discourage patients from receiving neoadjuvant chemotherapy when it's indicated," adds the study's clinical team.
Paper Context: In addition, the finding that EV-associated ANXA6 levels increased on-therapy in one patient with progressive disease (patient no. 52) strongly suggests that EV-associated ANXA6 was in fact of cancer cell origin. Although limited, these data support the notion that chemotherapy augments ANXA6 levels in the circulating EVs of patients with breast cancer.