News Finding: "Prophylaxis versus OD in adults with severe hemophilia A and arthropathy led to decreased bleeding, pain, and HRU, better joint health, activity, satisfaction, and HRQoL, but no reduction in structural arthropathy progression, suggesting preexisting joint arthropathy may be irreversible," the authors write.
Paper Finding: Conclusions: Over a period of 3 years, prophylaxis versus OD in adults with severe hemophilia A and arthropathy led to decreased bleeding, pain, and HRU, better joint health, activity, satisfaction, and HRQoL, but no reduction in structural arthropathy progression, suggesting that preexisting joint arthropathy may be irreversible.
News Context: There was no difference in magnetic resonance imaging score changes for prophylaxis versus OD. "Prophylaxis versus OD in adults with severe hemophilia A and arthropathy led to decreased bleeding, pain, and HRU, better joint health, activity, satisfaction, and HRQoL, but no reduction in structural arthropathy progression, suggesting preexisting joint arthropathy may be irreversible," the authors write. Several authors disclosed financial ties to pharmaceutical companies, including Bayer AG, which funded the study.
Paper Context: • Prophylaxis improved function, quality of life, activity and pain but not joint structure by MRI. Conclusions: Over a period of 3 years, prophylaxis versus OD in adults with severe hemophilia A and arthropathy led to decreased bleeding, pain, and HRU, better joint health, activity, satisfaction, and HRQoL, but no reduction in structural arthropathy progression, suggesting that preexisting joint arthropathy may be irreversible. • Prophylaxis improved function, quality of life, activity and pain but not joint structure by MRI.