News Finding: "It turned out cancers are very different from one organ to another and from person to person.
Paper Finding: We found that mTORC1 activity was specifically required for progression through S-phase.
News Context: The findings about how mature cells begin dividing again -- a process the researchers have named paligenosis -- are reported Feb. 15 in The EMBO Journal. "It turned out cancers are very different from one organ to another and from person to person. But if, as this study suggests, the way that cells become proliferative again is similar across many different organs, we can imagine therapies that interfere with cancer initiation in a more global way, regardless of where that cancer may appear in the body."
Paper Context: A similar pattern of changes in mTORC1 activity relative to metaplasia and the differentiated vs. proliferative phenotype was observed in human patients. We found that mTORC1 activity was specifically required for progression through S-phase. mTORC1 activation is also needed for yeast to pass through G1 into S-phase as they emerge from quiescence .