News Finding: Two of these variants proved able to fend off SUDV in specially bred mice.
Paper Finding: These antibodies represent strong immunotherapeutic candidates for treatment of SUDV infection.
News Context: Needing a "humanized" version of their mouse antibody, the researchers realized that its molecular structure closely resembled the structure of a commonly used human antibody. Two of these variants proved able to fend off SUDV in specially bred mice. "These two monoclonal antibodies represent potential candidates for treating SUDV infection," said Dr. Lai.
Paper Context: E10 and F4 were further shown to bind to the same epitope on GP as 16F6 with comparable affinities. These antibodies represent strong immunotherapeutic candidates for treatment of SUDV infection. 2 EBOV and SUDV are the most pathogenic among the ebolaviruses, and both have been associated with recurring outbreaks.