News Finding: This research in rats opens up new possibilities for developing therapies for cerebral SVD."
Paper Finding: This increase was due to both a block in OPC differentiation to mature oligodendrocytes (fewer mature Olig2 + Nogo-A + oligodendrocytes; Fig.
News Context: Nathan Richardson, Ph.D., the MRC's head of molecular and cellular medicine, commented: "This study is a great example of how innovative discovery science into regenerative mechanisms can be applied to improve our understanding of how vascular changes contribute to dementia. This research in rats opens up new possibilities for developing therapies for cerebral SVD." Indeed, the brain cell damage in the rats caused by the blood vessel changes was prevented by treatment with endothelial cell-stabilizing drugs, providing evidence for a potential path for the development of a therapeutic approach for dementia.
Paper Context: 1, J, M, and N) . This increase was due to both a block in OPC differentiation to mature oligodendrocytes (fewer mature Olig2 + Nogo-A + oligodendrocytes; Fig. 1O ) and an increase in OPC proliferation ( Fig.