News Finding: Time will tell if it [stands up]," says Willour.
Paper Finding: All individuals included were Caucasian, 85.1% were of German origin, and the remaining patients were of European descent (Central Europe, 6.5%; Eastern Europe, 7.8%; and Mediterranean, 0.6%).
News Context: They say more data is needed. "It's a striking finding, but as always, when you look at complex genetics, you need replication. Time will tell if it [stands up]," says Willour.
Paper Context: Further candidate gene approaches revealed associations of markers within FK506-binding protein 5 (FKBP5) in the Treatment of Resistant Depression in Adolescents (TORDIA) study and in FKBP5 and ATP-binding cassette, subfamily B (MDR/TAP), member 1 (ABCB1) in a sample of depressed outpatients . All individuals included were Caucasian, 85.1% were of German origin, and the remaining patients were of European descent (Central Europe, 6.5%; Eastern Europe, 7.8%; and Mediterranean, 0.6%). The non-TESI comparison groups were (1) all individuals without increase in suicidality independent of baseline suicidality (no increase of the HAM-D item 3 over time; n ¼ 329)Fbroader non-TESI group and (2) a subgroup of patients rating zero on item 3 throughout treatment (item 3 of the HAM-D ¼ 0 at all visits; n ¼ 79)Fnarrow non-TESI group.