News Finding: What they saw also clarified how Env compares to envelope proteins on other dangerous viruses, such as flu and Ebola.
Paper Finding: (E) bnAbs from (D) contain acidic HFR3 residues that interact with the basic residues in the highlighted area.
News Context: They obtained new data, which helped them understand the process by which the Env trimer undergoes radical shape changes during infection. What they saw also clarified how Env compares to envelope proteins on other dangerous viruses, such as flu and Ebola. "The new data ... have enabled us to explain many prior observations about HIV in structural terms for the first time," Dr. Jean-Philippe Julien, a senior research associate at Scripps, stated in a press release.
Paper Context: In addition to their previously known CD4bs epitopes, these bnAbs also interact with the V3 tip and proximal region near the protomer interface (red box). (E) bnAbs from (D) contain acidic HFR3 residues that interact with the basic residues in the highlighted area. Close-up views show the antibody HFR3 interactions with basic residues in the trimer highlighted in the red boxed regions in (D).