News Finding: The use of #chemotherapy in #BreastCancer is standard &amp; effective, however despite it, patients still develop metastasis. New #research published at @username suggests that chemo treated breast tumors produce small vesicles that could aid metastasis.  
Paper Finding: Accordingly, Anxa6 KO bEnd.3 cells had defective NF-kB activation and Ccl2 transcription in response to tumour-necrosis factor (TNF) compared with Anxa6 WT cells; notably, neither Csf1 nor Cxcl12 were regulated by ANXA6 ( Supplementary Fig.
News Context: The use of #chemotherapy in #BreastCancer is standard &amp; effective, however despite it, patients still develop metastasis. New #research published at @username suggests that chemo treated breast tumors produce small vesicles that could aid metastasis.  
Paper Context: Conversely, PTX-EVs isolated from 4T1-mCh or PyMT-IK1 cells increased NF-kB activity and Ccl2 expression in Rela-proficient bEnd.3 cells; notably, these responses required ANXA6 in EVs. Accordingly, Anxa6 KO bEnd.3 cells had defective NF-kB activation and Ccl2 transcription in response to tumour-necrosis factor (TNF) compared with Anxa6 WT cells; notably, neither Csf1 nor Cxcl12 were regulated by ANXA6 ( Supplementary Fig. Similar to PTX-EV, DOX-EVs from 4T1 cells increased the levels of Ccl2 transcripts (Fig.