News Finding: "These findings highlight a critical role for excess prenatal AMH exposure and subsequent aberrant GnRH receptor signaling in the neuroendocrine dysfunctions of PCOS, while offering a new potential therapeutic avenue to treat the condition during adulthood," the researchers wrote.
Paper Finding: The very low progesterone and E2 levels detected in AMH-treated pregnant mice, most likely due to compromised placental function, could explain the higher incidence of aborted embryos observed in these animals as compared to controls (Supplementary Fig.
News Context: "These findings highlight a critical role for excess prenatal AMH exposure and subsequent aberrant GnRH receptor signaling in the neuroendocrine dysfunctions of PCOS, while offering a new potential therapeutic avenue to treat the condition during adulthood," the researchers wrote. Pregnant mice received high levels of AMH, and researchers found they developed symptoms of PCOS, including irregular menstruation, fertility issues and late puberty. These excess levels of AMH spurred brain cells in the fetus to produce too much testosterone.
Paper Context: These findings are in line with clinical investigations, which have identified lower placental aromatase activity in women with PCOS ; this might be partly attributable to elevated levels of circulating AMH. The very low progesterone and E2 levels detected in AMH-treated pregnant mice, most likely due to compromised placental function, could explain the higher incidence of aborted embryos observed in these animals as compared to controls (Supplementary Fig. 8 ).