News Finding: "This important research helps us understand why small vessel disease happens, providing a direct link between small blood vessels and changes in the brain that are linked to dementia," Dr. Anna Williams, group leader at the University of Edinburgh's Medical Research Council Center for Regenerative Medicine, said in a press release.
Paper Finding: Simvastatin, perindopril, and cilostazol reversed the increase in OPCs seen in untreated DM rats (P < 0.001, P < 0.001, and P < 0.01, respectively; Fig.
News Context: "This important research helps us understand why small vessel disease happens, providing a direct link between small blood vessels and changes in the brain that are linked to dementia," Dr. Anna Williams, group leader at the University of Edinburgh's Medical Research Council Center for Regenerative Medicine, said in a press release. "It also shows that these changes may be reversible, which paves the way for potential treatments." For the first time, researchers found how changes in the small blood vessels associated with SVD damage brain cells.
Paper Context: Cilostazol showed trend effects only in the same direction. Simvastatin, perindopril, and cilostazol reversed the increase in OPCs seen in untreated DM rats (P < 0.001, P < 0.001, and P < 0.01, respectively; Fig. In the case of simvastatin and perindopril, this is by both reducing the OPC differentiation block (P < 0.001 for both; Fig.