News Finding: A paper @username looks at APC's tumor suppressor role in colonic crypts in light of the tissue architecture  #OA
Paper Finding: Our results reveal a tumor suppressing function arising from the interactions between dynamic subcellular APC network and the adhesion gradient in the crypt, which promotes the elimination of mutant cells with high Wnt signaling.
News Context: A paper @username looks at APC's tumor suppressor role in colonic crypts in light of the tissue architecture  #OA
Paper Context: This observation suggests that the effects of mutations are modulated by a dynamic competition between tumor promoting and suppressive forces that may depend on the signaling status of individual cells and their local microenvironment. Our results reveal a tumor suppressing function arising from the interactions between dynamic subcellular APC network and the adhesion gradient in the crypt, which promotes the elimination of mutant cells with high Wnt signaling. Subversion of these interactions permits mutant cells to persist in the crypt and initiate CRC.