News Finding: "I don't think it's easy to tell how that will happen."
Paper Finding: CD4 domains 1 and 2 (blue) fused to the human IgG1 Fc domain (grey).
News Context: But he sounded a note of caution since it's only been tested in a laboratory and in animals. "It's perhaps a better construct than the antibodies we've been using, but it's a matter of how it plays out in human trials," Baltimore said. "I don't think it's easy to tell how that will happen."
Paper Context: Importantly, our lead eCD4-Ig variant, eCD4-Ig mim2 , neutralized 100% of the isolates assayed at concentrations (IC 50 , 1.5 mg ml 21 ; IC 80 , 5.2 mg ml 21 ) that are probably sustainable in humans. CD4 domains 1 and 2 (blue) fused to the human IgG1 Fc domain (grey). Three uninfected eCD4-Ig treated mice and the sole uninfected mock treated mouse were rechallenged 5 weeks after the first challenge.