News Finding: Visiting the doctor to get vaccinated before a trip can prevent travelers from catching a disease.
Paper Finding: The difference between environmental atmospheres was a major discrepancy between our aerobically grown laboratory comparison and ETEC in infected stool.
News Context: "If we can understand how ETEC causes disease, we can develop new vaccines to prevent infections," Trent said. Visiting the doctor to get vaccinated before a trip can prevent travelers from catching a disease. They were surprised to find that ETEC produced more toxins when grown in the laboratory than it did in human infection samples.
Paper Context: Surprisingly, classical virulence factors were largely down-regulated in stool compared with standard laboratory growth, including cfaD, the cfa operon, and eltAB (Figs. The difference between environmental atmospheres was a major discrepancy between our aerobically grown laboratory comparison and ETEC in infected stool. Despite the in vivo relevance of growth in limited oxygen atmospheres, we found little published research describing ETEC in such conditions.