News Finding: The rational modulation of T-cell senescence would be a promising avenue for the treatment or prevention of diabetes.
Paper Finding: These suggest that T-cell senescence-mediated reprogramming of metabolic pathways may be associated with development of diabetes and its complications, as well as other aging-related diseases.
News Context: We also found that T-cell senescence is associated with systemic inflammation and alters hepatic glucose homeostasis. The rational modulation of T-cell senescence would be a promising avenue for the treatment or prevention of diabetes. Post a comment; thoughtful, considered opinions are valued.
Paper Context: In addition, we demonstrated that these CD8 + CD28 − T cells reside within the liver and are more numerous in the liver of aged and HFD-fed mice. These suggest that T-cell senescence-mediated reprogramming of metabolic pathways may be associated with development of diabetes and its complications, as well as other aging-related diseases. • In conclusion, we identified a link between the numbers and secretion of effector molecules by senescent T cells, and blood glucose status, in humans and mice.