News Finding: Treating rats with drugs that stop blood vessel cells from becoming dysfunctional reversed the symptoms of SVD and prevented brain damage, tests found.
Paper Finding: A blocking antibody specific to HSP90 abrogated the DM BMEC-CM-induced maturation defects (Fig.
News Context: Treatment also prevents damage to brain cells caused by these blood vessel changes, raising hope that it could offer a therapy for dementia. Treating rats with drugs that stop blood vessel cells from becoming dysfunctional reversed the symptoms of SVD and prevented brain damage, tests found. Researchers say that further studies will need to test whether the treatment also works when the disease is firmly established.
Paper Context: 3 , N to Q), mirroring the effect seen with DM BMEC-CM, but had no effect on OPC proliferation compared to controls ( fig. A blocking antibody specific to HSP90 abrogated the DM BMEC-CM-induced maturation defects (Fig. 3 , R to V), but again, OPC proliferation was unchanged ( fig.