News Finding: It also plays out in the brain.
Paper Finding: Nevertheless, cis-PET could be an interesting lead for drug development as it might have fewer side effects than  9 -trans-THC and reduces prostaglandins.
News Context: This similarity doesnat just show up in the chemistry lab, though. It also plays out in the brain. THC (left) is not that different from cis-PET (right), which is found in some species of liverwort.
Paper Context: The abuse potential of Radula species is probably low, given the relatively moderate potency and low abundance of cis-PET (0.7 to 7% in an extract) (5, 6) as compared with marijuana, with  9 -trans-THC contents typically higher than 10% . Nevertheless, cis-PET could be an interesting lead for drug development as it might have fewer side effects than  9 -trans-THC and reduces prostaglandins. The likely relevance of signaling-specific CB1R pathways (37), in particular related to the reduced prostaglandin biosynthesis observed with the bibenzyl PET scaffold, will need to be studied in preclinical disease models.