News Finding: The authors also stress their findings should not discourage people from receiving neoadjuvant chemo when it is needed.
Paper Finding: Similar to the results obtained with PTX-EV, DOX-EV enhanced metastasis compared with PBS-EV in an MMTV-PyMTbased lung colonization assay (Fig.
News Context: They hope this will improve the effectiveness of neoadjuvant therapy. 'While this observation supports the significance of our findings, at the moment we don't know if annexin-A6 has any pro-metastatic activity in human breast cancer,' Professor De Palma added. The authors also stress their findings should not discourage people from receiving neoadjuvant chemo when it is needed.
Paper Context: Similar to the results obtained with 4T1 cells, PTX-EVs increased the number of metastatic nodules in this MMTV-PyMT-based lung colonization assay (Fig. Similar to the results obtained with PTX-EV, DOX-EV enhanced metastasis compared with PBS-EV in an MMTV-PyMTbased lung colonization assay (Fig. Notably, neither PTX nor DOX directly increased metastasis in this assay; rather, the free drugs limited, or even abated, lung colonization by MMTV-PyMT tumour-derived cells (Fig.