News Finding: This research in rats opens up new possibilities for developing therapies for cerebral small vessel disease."
Paper Finding: 4 , D, E, and L) and significantly increased mature TJs in DM rats (P < 0.05 for both; Fig.
News Context: Alzheimer's Research UK is very pleased to have helped fund this innovative research, which is only possible thanks to the work of our dedicated supporters." Dr Nathan Richardson, the MRC's Head of Molecular and Cellular Medicine, commented: "This study is a great example of how innovative discovery science into regenerative mechanisms can be applied to improve our understanding of how vascular changes contribute to dementia. This research in rats opens up new possibilities for developing therapies for cerebral small vessel disease."
Paper Context: Simvastatin and perindopril significantly reduced EC proliferation (P < 0.001 for both; Fig. 4 , D, E, and L) and significantly increased mature TJs in DM rats (P < 0.05 for both; Fig. 4 , F, G, and M), confirming that these drugs improve endothelial dysfunction.