News Finding: For the first time, researchers found how changes in the small blood vessels associated with SVD damage brain cells.
Paper Finding: We looked at 304 SNPs within ATP11B and found seven SNPs, which were significantly associated with WMH (P < 0.05; fig.
News Context: "It also shows that these changes may be reversible, which paves the way for potential treatments." For the first time, researchers found how changes in the small blood vessels associated with SVD damage brain cells. Rats treated with endothelial cell-stabilizing drugs stopped the blood vessel cells from becoming dysfunctional.
Paper Context: 5 , T and U), linking the upstream and downstream pathways and suggesting a similar mechanism of action to DM BMECs. We looked at 304 SNPs within ATP11B and found seven SNPs, which were significantly associated with WMH (P < 0.05; fig. After correcting for multiple testing, using spectral decomposition to determine the number of independent SNPs tested using the 1000 Genomes Project reference as a measure of linkage disequilibrium (41), we found one intronic SNP, which was associated with WMH burden: rs148771930 (P = 0.00025).