News Finding: They found these neuronal networks showed too much activity, firing too often and in synch, much more than a normal brain.
Paper Finding: However, in our in vivo whole-cell recordings of L2/3 neurons in unanesthetized mice at P1- we found no significant differences between wildtype and Fmr1 −/− mice in the duration of Up states (wild type, 1.30 ± 0.06 s, n = 5 cells ; Fmr1 −/− , 1.29 ± 0.1 s, n = 6 cells; P = 0.92, t test; Fig.
News Context: They found these neuronal networks showed too much activity, firing too often and in synch, much more than a normal brain. This neuronal excitability may also be the basis for symptoms in children with FXS, which can include disrupted sleep, seizures, or learning disabilities. The findings may lead to treatments that could quiet the excessive activity and allow for more normal behavior.
Paper Context: In addition, we found that recorded neurons in npg a r t I C l e S which suggests that the differences in firing rates (or correlation coefficients) were not a result of differences in the overall state of vigilance of mice from either genotype. However, in our in vivo whole-cell recordings of L2/3 neurons in unanesthetized mice at P1- we found no significant differences between wildtype and Fmr1 −/− mice in the duration of Up states (wild type, 1.30 ± 0.06 s, n = 5 cells ; Fmr1 −/− , 1.29 ± 0.1 s, n = 6 cells; P = 0.92, t test; Fig. a-c) , in the frequency of Up states (wild type, 0.38 ± 0.03 Hz; Fmr1 −/− , 0.36 ± 0.02 Hz; P = 0.6, t test; Fig.