News Finding: If using vape devices for flavors is normalized among teens, Volkow says, then "it's much easier to do that transition of using them and combining them with nicotine," which is highly addictive.
Paper Finding: We further explore this sensitivity in eFigure 3, Panels C and D. As the probability of publishing the study with the largest standard error decreases from 100% to 40%, the estimated adjusted pooled odds ratio deceases from 3.57 (e 1.27 ) to 2.59 (e 0.95 ; eFigure 3, Panel C).
News Context: "That's how the addiction process is triggered and initiated, so that is definitely an area of concern," she continues. If using vape devices for flavors is normalized among teens, Volkow says, then "it's much easier to do that transition of using them and combining them with nicotine," which is highly addictive. And accessibility matters: high school seniors in states with medical marijuana laws are more likely to have vaped or consumed marijuana than those in states without such laws, according to the report.
Paper Context: The contour plot (eFigure 3, Panel B) suggests that the estimated adjusted pooled odds ratio from the meta-analysis may be sensitive (i.e., varies between 0.7 and 1.25) to the range of ( 0 ,  1 ) values. We further explore this sensitivity in eFigure 3, Panels C and D. As the probability of publishing the study with the largest standard error decreases from 100% to 40%, the estimated adjusted pooled odds ratio deceases from 3.57 (e 1.27 ) to 2.59 (e 0.95 ; eFigure 3, Panel C). Notably, the confidence interval of the adjusted pooled odds ratio remains above 1 (i.e., confidence interval of log odds ratio remains above 0) across the range of probabilities of publishing the study with the largest standard error.