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Paper Finding: Conversely, PTX did not alter the relative abundance of Ly6C + monocytes in the lungs of tumour-free mice (Fig.
News Context: "Our findings must not discourage patients from receiving neoadjuvant chemotherapy when it's indicated," adds the study's clinical team. Note: material may have been edited for length and content. For further information, please contact the cited source.
Paper Context: Consistent with the upregulation of CCL2, PTX increased the relative abundance of Ly6C + monocytes in the lungs of 4T1-mCh tumour-bearing Rag1 −/− mice, 4T1 tumour-bearing Balb/c mice, 4T1-mCh/HER2 tumour-bearing Swiss nu/nu mice and transgenic MMTV-PyMT mice compared with the vehicle (Fig. Conversely, PTX did not alter the relative abundance of Ly6C + monocytes in the lungs of tumour-free mice (Fig. These results indicate that signals emanating from primary tumours are required for PTX-induced upregulation of CCL2 and expansion of Ly6C