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Paper Finding: We looked at 304 SNPs within ATP11B and found seven SNPs, which were significantly associated with WMH (P < 0.05; fig.
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Paper Context: 5 , T and U), linking the upstream and downstream pathways and suggesting a similar mechanism of action to DM BMECs. We looked at 304 SNPs within ATP11B and found seven SNPs, which were significantly associated with WMH (P < 0.05; fig. After correcting for multiple testing, using spectral decomposition to determine the number of independent SNPs tested using the 1000 Genomes Project reference as a measure of linkage disequilibrium (41), we found one intronic SNP, which was associated with WMH burden: rs148771930 (P = 0.00025).