News Finding: To their surprise, the researchers found that drugs with very different molecular structures produced similar metabolic responses.
Paper Finding: It is capable of performing flux-balance analysis to integrate and interpret a variety of emerging data types, including linking mutations identified from human variation data or cancer genome atlases.
News Context: Using Recon3D, researchers found that other harmful mutations were significantly more likely to neighbor mutations that were also harmful. To their surprise, the researchers found that drugs with very different molecular structures produced similar metabolic responses. Drug developers could use this tool to explore whether certain drugs can be repurposed to treat other diseases for which they weren't originally developed, Brunk noted.
Paper Context: Mutations co-occurring in the same location as other mutations are significantly more likely to be associated with somatic mutations, when compared to a random selection (P < 0.02, , and metabolite structures from CHEBI . It is capable of performing flux-balance analysis to integrate and interpret a variety of emerging data types, including linking mutations identified from human variation data or cancer genome atlases. ).