News Finding: Its maximum strength varied with the total tumor volume in a mouse's lungs, suggesting that the test may be sensitive not only to the presence of cancer but also to its extent.
Paper Finding: First is the opportunity to optimize our system iteratively to improve the stringency of tumor-activatable gene expression, to generate more potent vectors, and to enhance vector delivery to the tumor.
News Context: That signal began declining in strength as early as 72 hours post-injection, fading to insignificance within the next two weeks or so. Its maximum strength varied with the total tumor volume in a mouse's lungs, suggesting that the test may be sensitive not only to the presence of cancer but also to its extent. Importantly, they're also incapable of integrating randomly into a host cell's genome -- and, possibly, right into the middle of a gene, disrupting that gene's operation.
Paper Context: Our tumor-activatable MC system has many distinct advantages over the detection of endogenously expressed cancer blood biomarkers. First is the opportunity to optimize our system iteratively to improve the stringency of tumor-activatable gene expression, to generate more potent vectors, and to enhance vector delivery to the tumor. In contrast, we can tune our MC system's sensitivity.