News Finding: "One of the main advantages of cannabidiol is that it is safe and seems to be very well tolerated, making it in some ways an ideal treatment.
Paper Finding: As expected and in line with data from previous neuroimaging comparisons of participants at CHR of psychosis with controls, 52-54 we found that under placebo conditions, participants at CHR showed differential activation relative to controls in several regions.
News Context: "There is an urgent need for a safe treatment for young people at risk of psychosis," says Dr Bhattacharyya. "One of the main advantages of cannabidiol is that it is safe and seems to be very well tolerated, making it in some ways an ideal treatment. If successful, this trial will provide definitive proof of cannabidiol's role as an antipsychotic treatment and pave the way for use in the clinic."
Paper Context: Across all participants, the total recall score was directly correlated with the level of left parahippocampal activation during recall (r = 0.28; P = .046) (eResults in Supplement 2). As expected and in line with data from previous neuroimaging comparisons of participants at CHR of psychosis with controls, 52-54 we found that under placebo conditions, participants at CHR showed differential activation relative to controls in several regions. These regions of differential response included the 3 areas thought to be critical to the pathophysiology of the CHR state: the striatum (during verbal encoding) and the MTL and midbrain (during verbal recall).