News Finding: The researchers thus provide a possible explanation for why these drugs are not effective in colorectal cancer.
Paper Finding: As shown in Fig.
News Context: The researchers thus provide a possible explanation for why these drugs are not effective in colorectal cancer. Depending on the Wnt activity, the cancer cells can switch back and forth between the stem cell state and a differentiated state. At the same time, the gene activity of the cancer cells changed to a stem cell-typical pattern.
Paper Context: AXIN1 is regulated by MEK inhibition. As shown in Fig. 5a , phospho-ERK and its downstream target phospho-RSK were reduced in trametinib treated cells, demonstrating effective inhibition of the RAS pathway.