News Finding: They hope this will improve the effectiveness of neoadjuvant therapy.
Paper Finding: However, therapy-induced host responses 7 , such as those described in our study, may limit the benefits of pre-operative treatments in some patients.
News Context: When the researchers neutralised annexin-A6 or blocked the monocytes, the experimental breast tumour no longer spread to the lungs. They hope this will improve the effectiveness of neoadjuvant therapy. 'While this observation supports the significance of our findings, at the moment we don't know if annexin-A6 has any pro-metastatic activity in human breast cancer,' Professor De Palma added.
Paper Context: Although limited, these data support the notion that chemotherapy augments ANXA6 levels in the circulating EVs of patients with breast cancer. However, therapy-induced host responses 7 , such as those described in our study, may limit the benefits of pre-operative treatments in some patients. However, it should be cautioned that we did not study the survival of mice in association with the various treatments, so we currently ignore whether increased metastatic seeding and outgrowth in response to chemotherapy-elicited EVs would translate into shorter survival in our experimental cancer models.