News Finding: When the researchers neutralised annexin-A6 or blocked the monocytes, the experimental breast tumour no longer spread to the lungs.
Paper Finding: + monocytes mediate EV-induced, pulmonary mammary cancer metastasis.
News Context: 'In short, our study has identified a new link between chemotherapy and breast cancer metastasis,' Professor De Palma said. When the researchers neutralised annexin-A6 or blocked the monocytes, the experimental breast tumour no longer spread to the lungs. They hope this will improve the effectiveness of neoadjuvant therapy.
Paper Context: These data strongly argue that Ly6C + monocytes mediate EV-induced, pulmonary mammary cancer metastasis. Because Anxa6 KO PTX-EV failed to enhance pulmonary colonization by 4T1-mCh cells (Fig.