News Finding: However, "By showing that reductions in portal pressure induced by NSBB-based pharmacologic therapy improve outcomes and decrease mortality, our study supports the use of NSBB in all clinical settings (primary or secondary prophylaxis) and in both patients with or without ascites," they concluded.
Paper Finding: By showing that reductions in portal pressure induced by NSBBbased pharmacologic therapy improve outcomes and decrease mortality, our study supports the use of NSBB in all clinical settings (primary or secondary prophylaxis) and in both patients with or without ascites.
News Context: The study findings were limited by several factors, including the use of retrospective data from prospective studies, and the incomplete collection of data on the variables of comorbidities, hepatocellular carcinoma, and other predictive scores; alcohol use or abstinence was a potential confounder as well, the researchers noted. However, "By showing that reductions in portal pressure induced by NSBB-based pharmacologic therapy improve outcomes and decrease mortality, our study supports the use of NSBB in all clinical settings (primary or secondary prophylaxis) and in both patients with or without ascites," they concluded. They found no heterogeneity among the studies included in the analysis.
Paper Context: Importantly, achieving an HVPG response improves survival in patients with ascites and a previous episode of bleeding who are notoriously those patients with the poorest survival rate. By showing that reductions in portal pressure induced by NSBBbased pharmacologic therapy improve outcomes and decrease mortality, our study supports the use of NSBB in all clinical settings (primary or secondary prophylaxis) and in both patients with or without ascites. 2321  2322  2323  2324  2325  2326  2327  2328  2329  2330  2331  2332  2333  2334  2335  2336  2337  2338  2339  2340  2341  2342  2343  2344  2345  2346  2347  2348  2349  2350  2351  2352  2353  2354  2355  2356  2357  2358  2359  2360  2361  2362  2363  2364  2365  2366  2367  2368  2369  2370  2371  2372  2373  2374  2375  2376  2377  2378  2379  2380  2381  2382  2383