News Finding: "The identification and characterization of CD8 T cell epitopes in mice immunized with a Zika RNA vaccine is a very useful
Paper Finding: No peptide other than IGVSNRDFV induced a detectible CD8 + T cell response ( Figure S2 ).
News Context: They identified a sequence of eight amino acids that the activated T cells in the mouse respond to. Now that this sequence, also called an epitope, is known, other researchers can use it to test their own experimental Zika vaccines in the appropriate mouse models. "The identification and characterization of CD8 T cell epitopes in mice immunized with a Zika RNA vaccine is a very useful
Paper Context: Incubation with the putative H-2K b -restricted peptide IAPAYSIRCIGV resulted in no activation. No peptide other than IGVSNRDFV induced a detectible CD8 + T cell response ( Figure S2 ). Given the threat of the ZIKV outbreak and likelihood of continuing transmission worldwide, accelerated vaccine development is critical.