News Finding: Considered to be of great value for medical science, their work will help virologists identify the sites an experimental vaccine need mimic in order to elicit a strong response from the body's immune system.
Paper Finding: The crystal structure of a scaffolded V1/V2 protein [PDB ID: 3U4E (9)] could also be fitted into density at the trimer apex ( Fig.
News Context: Considered to be of great value for medical science, their work will help virologists identify the sites an experimental vaccine need mimic in order to elicit a strong response from the body's immune system. They obtained new data, which helped them understand the process by which the Env trimer undergoes radical shape changes during infection. What they saw also clarified how Env compares to envelope proteins on other dangerous viruses, such as flu and Ebola.
Paper Context: The EM map presented here is substantially improved in resolution and in features relative to previous trimer reconstructions; it also revealed partially discontinuous density surrounding the periphery of the trimer that is consistent with N-linked glycans on both gp120 and gp41 ( fig. The crystal structure of a scaffolded V1/V2 protein [PDB ID: 3U4E (9)] could also be fitted into density at the trimer apex ( Fig. S4 and S5A) and are consistent with the arrangement of the V1/V2 Asn 156 and Asn 160 glycans predicted by a low-resolution model of the same trimer in complex with bnAb PG9 (14) .