News Finding: New paper out in JAMA Psychiatry, showing the effects of cannabidiol on brain function of people at high risk for psychosis.
  
Paper Finding: As expected and in line with data from previous neuroimaging comparisons of participants at CHR of psychosis with controls, 52-54 we found that under placebo conditions, participants at CHR showed differential activation relative to controls in several regions.
News Context: New paper out in JAMA Psychiatry, showing the effects of cannabidiol on brain function of people at high risk for psychosis.
  
Paper Context: Across all participants, the total recall score was directly correlated with the level of left parahippocampal activation during recall (r = 0.28; P = .046) (eResults in Supplement 2). As expected and in line with data from previous neuroimaging comparisons of participants at CHR of psychosis with controls, 52-54 we found that under placebo conditions, participants at CHR showed differential activation relative to controls in several regions. These regions of differential response included the 3 areas thought to be critical to the pathophysiology of the CHR state: the striatum (during verbal encoding) and the MTL and midbrain (during verbal recall).