News Finding: Our paper on MEK inhibitors, Wnt signaling and stem cell plasticity in colorectal cancer just got published @username Great collaboration with Matthias Ebert @username 
Paper Finding: This finding indicates that GSK3B and MEK/ERK act on Wnt signalling by distinct mechanisms, which can be independently targeted by small molecules.
News Context: Our paper on MEK inhibitors, Wnt signaling and stem cell plasticity in colorectal cancer just got published @username Great collaboration with Matthias Ebert @username 
Paper Context: Surprisingly, we also observed that APC truncations synergize with MEK and ERK inhibition to activate Wnt, while they completely abolish the stimulating effect of GSK3B inhibitors. This finding indicates that GSK3B and MEK/ERK act on Wnt signalling by distinct mechanisms, which can be independently targeted by small molecules. Although APC mutations remain the most important driver of Wnt signalling in CRC , many Wnt components can modulate the signal output in spite of APC truncations.