News Finding: That means that physicians like myself need to evaluate patients on an individual basis and find the best way to treat their pain.
Paper Finding: Effects of HAT inhibitors and HDAC inhibitors on neuropathic pain-Several groups reported that the HDAC inhibitors had an antinociceptive effect in neuropathic pain.
News Context: That means that physicians like myself need to evaluate patients on an individual basis and find the best way to treat their pain. A major gap looms between the patient's experience of pain and the limited "one size fits all" treatment that doctors may offer. Four in 10 of these deaths involved prescription painkillers such as hydrocodone and oxycodone.
Paper Context: However, the targets of histone acetylation were not known in this study. Effects of HAT inhibitors and HDAC inhibitors on neuropathic pain-Several groups reported that the HDAC inhibitors had an antinociceptive effect in neuropathic pain. Oral administration of Sodium butyrate, a HDAC inhibitor, not only attenuated chronic constriction injury (CCI)-induced pain hypersensitivity but also reduced the CCI-induced increase in TNF-αin the sciatic nerve (Table 1) .