News Finding: But much more must be done, say the authors.
Paper Finding: Sporadic MSI-H CRCs that arise from sessile serrated adenomas demonstrate FS mutations at the same hotspot microsatellite loci as in LS CRC.
News Context: It does so countless times every day in all of us. But much more must be done, say the authors. Both should be dramatically expanded to cancer prevention, the authors write.
Paper Context: This approach would also facilitate vaccine-based prevention for sporadic MSI-H carcinogenesis, which is implicated in subsets of many cancers . Sporadic MSI-H CRCs that arise from sessile serrated adenomas demonstrate FS mutations at the same hotspot microsatellite loci as in LS CRC. Although LS awareness is increasing the use of universal tumor testing of CRC (and now endometrial) specimens for MSI-H/ MMR-D and access to NGS germ-line testing, implementation is a major challenge.