News Finding: They hope this will improve the effectiveness of neoadjuvant therapy.
Paper Finding: In addition, the EV-associated proteins CD9, CD81 and syntenin-1 were enriched in EVs compared with producer cells as demonstrated by western blot analysis ( Supplementary Fig.
News Context: When the researchers neutralised annexin-A6 or blocked the monocytes, the experimental breast tumour no longer spread to the lungs. They hope this will improve the effectiveness of neoadjuvant therapy. 'While this observation supports the significance of our findings, at the moment we don't know if annexin-A6 has any pro-metastatic activity in human breast cancer,' Professor De Palma added.
Paper Context: The resulting preparations were highly enriched in small EVs, as shown by both transmission electron microscopy (TEM; Fig. In addition, the EV-associated proteins CD9, CD81 and syntenin-1 were enriched in EVs compared with producer cells as demonstrated by western blot analysis ( Supplementary Fig. Although we cannot rule out copurification of small apoptotic bodies, the physical and molecular properties of the preparations are consistent with bona fide EVs with a mode size between 100 and 150 nm.