CID Question Answer 54675783 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C Question about this molecule: What is the right information about this molecule's absorption? Option A: It has minimal oral absorption. Option B: It undergoes very little absorption following oral or topical administration. Option C: It has good absorption and enhanced oral bioavailability. Option D: It has excellent absorption and tissue penetration. " D 297 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C Question about this molecule: What is the right information about this molecule's absorption? Option A: It is rapidly absorbed from the gastrointestinal tract and distributed throughout the body. Option B: It is absorbed through foliage and roots and translocated into the plant. Option C: It is absorbed from the colon and excreted in expired air. Option D: It can be absorbed systemically through inhalation, ingestion, and the skin. " C 64929 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C(=O)O)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl Question about this molecule: What is the right information about this molecule's absorption? Option A: It has poor absorption profile, and prodrug and other conjugated compounds have been developed for improved solubility, gastrointestinal absorption, and bioavailability. Option B: It is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. Option C: Its absorption in man is effected over a longer period of time as compared to corticotropin. Option D: It is well absorbed in the gut with an oral bioavailability of 100% and easily crosses the blood-brain barrier. " A 9395 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=O)(OCC)OC1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: What is the right information about this molecule's absorption? Option A: It is absorbed through the skin. Option B: It is absorbed through roots and foliage. Option C: It is easily absorbed through skin. Option D: It is rapidly absorbed through membranes. " C 25429 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)NC1=NC2=CC=CC=C2N1 Question about this molecule: What is the right information about this molecule's absorption? Option A: It is absorbed through roots and foliage. Option B: It is easily absorbed through skin. Option C: It is rapidly absorbed through membranes. Option D: It is absorbed through the roots and green tissues. " D 991 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OC1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: What is the right information about this molecule's absorption? Option A: It is absorbed through roots and foliage. Option B: The liquid is absorbed onto a dry carrier. Option C: It is rapidly absorbed through membranes. Option D: It is absorbed through the roots and green tissues. " B 6324616 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1/C=C/C=C(\\C(=O)NC2=CC(=C3C(=C2O)C(=C(C4=C3C(=O)[C@](O4)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)/C Question about this molecule: What is the right information about this molecule's absorption? Option A: It has minimal oral absorption. Option B: It has excellent absorption and tissue penetration. Option C: It has good absorption and enhanced oral bioavailability. Option D: It undergoes very little absorption following oral or topical administration. " A 3039 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=O)(OC)OC=C(Cl)Cl Question about this molecule: What is the right information about this molecule's absorption? Option A: The liquid is absorbed onto a dry carrier. Option B: It is rapidly absorbed through membranes. Option C: It is absorbed through the roots and green tissues. Option D: It is absorbed through roots and foliage. " A 15546 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)N2C(=O)C(=C(C=N2)N)Cl Question about this molecule: What is the right information about this molecule's absorption? Option A: It is absorbed by the roots and works by inhibiting root development and growth. Option B: It is rapidly absorbed through the roots of plants with tranlocation acropetally to all plant parts. Option C: It is well absorbed in the gut with an oral bioavailability of 100% and easily crosses the blood-brain barrier. Option D: Its absorption in man is effected over a longer period of time as compared to corticotropin. " B 441397 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)OC(C)OC(=O)[C@H]1C(S[C@H]2N1C(=O)[C@H]2NC(=O)[C@@H](C3=CC=CC=C3)N)(C)C Question about this molecule: What is the right information about this molecule's absorption? Option A: It is well absorbed in the gut with an oral bioavailability of 100% and easily crosses the blood-brain barrier. Option B: It is hydrolyzed by esterases present in the intestinal wall during absorption from the gastrointestinal tract. Option C: It is rapidly absorbed from the gastrointestinal tract and distributed throughout the body. Option D: It is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. " B 19395 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OP(=S)(OCC)OCC Question about this molecule: What is the right information about this molecule's absorption? Option A: It is absorbed through the roots and green tissues. Option B: The liquid is absorbed onto a dry carrier. Option C: It is rapidly absorbed through membranes. Option D: It is absorbed through roots and foliage. " B 29936 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Fe+3] Question about this molecule: What is the right information about this molecule's absorption? Option A: It undergoes very little absorption following oral or topical administration. Option B: It has good absorption and enhanced oral bioavailability. Option C: It must be reduced to the ferrous cation for absorption. Option D: It has excellent absorption and tissue penetration. " C 702 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCO Question about this molecule: What is the right information about this molecule's absorption? Option A: It is rapidly absorbed from the gastrointestinal tract and distributed throughout the body. Option B: It is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. Option C: It is rapidly absorbed through the roots of plants with tranlocation acropetally to all plant parts. Option D: It is well absorbed in the gut with an oral bioavailability of 100% and easily crosses the blood-brain barrier. " A 11430 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)([O-])[O-].[K+].[K+] Question about this molecule: What is the right information about this molecule's absorption? Option A: It is rapidly absorbed through membranes. Option B: It is absorbed through roots and foliage. Option C: It is absorbed through the roots and green tissues. Option D: It has a large capacity to absorb moisture. " D 27189 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)C(=O)C(C)OC1=CC=CC2=CC=CC=C21 Question about this molecule: What is the right information about this molecule's absorption? Option A: It is absorbed by the roots and works by inhibiting root development and growth. Option B: It is rapidly absorbed through the roots of plants with tranlocation acropetally to all plant parts. Option C: It is well absorbed in the gut with an oral bioavailability of 100% and easily crosses the blood-brain barrier. Option D: Its absorption in man is effected over a longer period of time as compared to corticotropin. " A 26623 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Hg+2] Question about this molecule: What is the right information about this molecule's absorption? Option A: It is well absorbed, and because the biological half-life is long, the body burden in humans may reach high levels. Option B: It is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. Option C: It is well absorbed in the gut with an oral bioavailability of 100% and easily crosses the blood-brain barrier. Option D: It is rapidly absorbed through the roots of plants with tranlocation acropetally to all plant parts. " A 5161 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)C(=O)OC2=CC=CC=C2C(=O)O)O Question about this molecule: What is the right information about this molecule's absorption? Option A: A significant portion of the parent compound is absorbed unchanged and undergoes rapid esterase hydrolysis in the body. Option B: It can be absorbed systemically through inhalation, ingestion, and the skin. Option C: It is rapidly absorbed through the roots of plants with tranlocation acropetally to all plant parts. Option D: It is rapidly absorbed from the gastrointestinal tract and distributed throughout the body. " A 7095 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2=CC=CC=C2 Question about this molecule: What is the right information about this molecule's absorption? Option A: It is absorbed through foliage and roots and translocated into the plant. Option B: It is absorbed through the roots and green tissues. Option C: It is absorbed into the outer waxy layer of plant surfaces. Option D: Some of it is absorbed by the fruit skins. " D 7862 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[Hg]Cl Question about this molecule: What is the right information about this molecule's absorption? Option A: It is absorbed through roots and foliage. Option B: It is easily absorbed through skin. Option C: It is rapidly absorbed through membranes. Option D: It is absorbed through the skin. " D 54738 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C1(C(=O)NC(=N1)C2=C(C=CC=N2)C(=O)O)C Question about this molecule: What is the right information about this molecule's absorption? Option A: It is absorbed by foliage and rapidly translocated. Option B: It is absorbed through roots and foliage. Option C: It is rapidly absorbed through membranes. Option D: It is absorbed through the roots and green tissues. " A 23976 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Cr] Question about this molecule: What is the right information about this molecule's absorption? Option A: Cr(III) is poorly absorbed whereas Cr(VI) is more readily absorbed. Option B: It is poorly absorbed if given orally and is used in urinary infections and typhus. Option C: It can be absorbed systemically through inhalation, ingestion, and the skin. Option D: It is better absorbed than tyrosine and may cause fewer headaches. " A 3286 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)SCSP(=S)(OCC)OCC Question about this molecule: What is the right information about this molecule's absorption? Option A: The liquid is absorbed onto a dry carrier. Option B: It is rapidly absorbed through membranes. Option C: It is absorbed through roots and foliage. Option D: It is absorbed through the roots and green tissues. " A 6423 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([N+](=O)[O-])(Cl)(Cl)Cl Question about this molecule: What is the right information about this molecule's absorption? Option A: It is rapidly absorbed through the roots of plants with tranlocation acropetally to all plant parts. Option B: It can be absorbed systemically through inhalation, ingestion, and the skin. Option C: It is poorly absorbed if given orally and is used in urinary infections and typhus. Option D: It is absorbed by the roots and works by inhibiting root development and growth. " B 41428 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=NC(=C1Cl)Cl)OCC(=O)O)Cl Question about this molecule: What is the right information about this molecule's absorption? Option A: It is rapidly absorbed through membranes. Option B: It is absorbed through the roots and green tissues. Option C: It is absorbed through roots and foliage. Option D: It is easily absorbed through skin. " C 91779 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCS(=O)(=O)C1=C(N=CC=C1)S(=O)(=O)NC(=O)NC2=NC(=CC(=N2)OC)OC Question about this molecule: What is the right information about this molecule's absorption? Option A: It is absorbed through the roots and green tissues. Option B: It is rapidly absorbed through membranes. Option C: It is absorbed through roots and foliage. Option D: It is absorbed through foliage and roots and translocated into the plant. " D 8378 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N Question about this molecule: What is the right information about this molecule's absorption? Option A: It has good absorption and enhanced oral bioavailability. Option B: It undergoes very little absorption following oral or topical administration. Option C: It has poor gastrointestinal absorption and is therefore formulated as a sublingual tablet. Option D: It has minimal oral absorption and its use has not been linked to instances of acute liver injury. " D 6140 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C[C@@H](C(=O)O)N Question about this molecule: What is the right information about this molecule's absorption? Option A: It is poorly absorbed if given orally and is used in urinary infections and typhus. Option B: It can be absorbed systemically through inhalation, ingestion, and the skin. Option C: It is better absorbed than tyrosine and may cause fewer headaches. Option D: It is rapidly absorbed from the gastrointestinal tract and distributed throughout the body. " C 167583 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [2HH] Question about this molecule: Which kind of abundance does this molecule have/exhibit? Option A: It has a natural abundance of 0.000137 atom percent. Option B: It has a natural abundance of 0.038 atom percent. Option C: It has a natural abundance of 70.476 atom percent. Option D: It has a natural abundance of 0.0115 atom percent. " D 6857639 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [3He] Question about this molecule: Which kind of abundance does this molecule have/exhibit? Option A: It has a natural abundance of 0.000137 atom percent. Option B: It has a natural abundance of 70.476 atom percent. Option C: It has a natural abundance of 0.0115 atom percent. Option D: It has a natural abundance of 0.038 atom percent. " A 5460631 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [1HH] Question about this molecule: Which kind of abundance does this molecule have/exhibit? Option A: It has a natural abundance of 99.76 atom percent. Option B: It has a natural abundance of 99.9885 atom percent. Option C: It has a natural abundance of 70.476 atom percent. Option D: It has a natural abundance of 92.23 atom percent. " B 10214376 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [16OH2] Question about this molecule: Which kind of abundance does this molecule have/exhibit? Option A: It has a natural abundance of 99.76 atom percent. Option B: It has a natural abundance of 29.524 atom percent. Option C: It has a natural abundance of 0.0115 atom percent. Option D: It has a natural abundance of 70.476 atom percent. " A 10197601 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [17OH2] Question about this molecule: Which kind of abundance does this molecule have/exhibit? Option A: It has a natural abundance of 0.0115 atom percent. Option B: It has a natural abundance of 70.476 atom percent. Option C: It has a natural abundance of 0.000137 atom percent. Option D: It has a natural abundance of 0.038 atom percent. " D 16019994 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [203Tl] Question about this molecule: Which kind of abundance does this molecule have/exhibit? Option A: It has a natural abundance of 99.76 atom percent. Option B: It has a natural abundance of 29.524 atom percent. Option C: It has a natural abundance of 0.0115 atom percent. Option D: It has a natural abundance of 70.476 atom percent. " B 16048636 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [28Si] Question about this molecule: Which kind of abundance does this molecule have/exhibit? Option A: It has a natural abundance of 99.76 atom percent. Option B: It has a natural abundance of 70.476 atom percent. Option C: It has a natural abundance of 99.9885 atom percent. Option D: It has a natural abundance of 92.23 atom percent. " D 5460511 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [4He] Question about this molecule: Which kind of abundance does this molecule have/exhibit? Option A: It has a natural abundance of 0.038 atom percent. Option B: It has a natural abundance of 70.476 atom percent. Option C: It has a natural abundance of 99.99 atom percent. Option D: It has a natural abundance of 0.0115 atom percent. " C 16019993 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [205Tl] Question about this molecule: Which kind of abundance does this molecule have/exhibit? Option A: It has a natural abundance of 70.476 atom percent. Option B: It has a natural abundance of 0.0115 atom percent. Option C: It has a natural abundance of 29.524 atom percent. Option D: It has a natural abundance of 99.76 atom percent. " A 443884 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](CO)NC(=O)[C@H]1CN([C@@H]2CC3=CNC4=CC=CC(=C34)C2=C1)C Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It exhibits the action of directly stimulating the uterine muscle to increase force and frequency of contractions. Option B: It causes relaxation of smooth muscle in blood vessels and the prostate. Option C: It has direct actions on blood vessels and increases cardiac output. Option D: It maintains uterine contraction and tone. " D 53262738 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@H](C(=O)O[C@H]1[C@H]([C@@H](C)[C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3CCC5=CC(=O)C=C[C@]45C)C)O)C Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It inhibits the accumulation of the pro-inflammatory iNOS protein. Option B: It exhibits the action of concentrating its anti-inflammatory action at the site of application due to being a privalate salt. Option C: It has cardiac stimulant action without evoking vasoconstriction or tachycardia. Option D: It has vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions. " A 5280497 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC[C@@H](/C=C/[C@@H]1[C@H]([C@@H]2C[C@@H](O2)O1)C/C=C\\CCCC(=O)O)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It stimulates activation of new platelets and increases platelet aggregation. Option B: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. Option C: It mediates smooth muscle relaxation and bronchodilation. Option D: It mediates a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis. " A 10743861 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(C)/C=C/C(=O)NC1=C[C@@]([C@H]2[C@@H](C1=O)O2)(/C=C/C=C/C=C/C(=O)NC3=C(CCC3=O)O)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It acts as an anti-inflammatory agent and antibiotic. Option B: It is an anti-arrhythmia drug and a sodium channel blocker. Option C: It is a calcium-channel blocker and vasodilator. Option D: It acts as an L-type calcium channel blocker. " A 53355241 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1[C@H](C(=O)O[C@H]1[C@H]([C@@H](C)[C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3CCC5=CC(=O)C=C[C@]45C)COC(=O)C)O)C Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It exhibits the action of concentrating its anti-inflammatory action at the site of application due to being a privalate salt. Option B: It has vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions. Option C: It has cardiac stimulant action without evoking vasoconstriction or tachycardia. Option D: It inhibits the accumulation of the pro-inflammatory iNOS protein. " D 10219 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@H]1CN2CCC3=CC(=C(C=C3[C@@H]2C[C@@H]1C[C@@H]4C5=CC(=C(C=C5CCN4)OC)OC)OC)OC Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties. Option B: It is an inhibitor of SARS coronavirus main proteinase and inhibits SARS-CoV-2 replication in cell culture. Option C: It prevents the interaction of HIV-1 gp120 and chemokine receptor 5 (CCR5) necessary for CCR5-tropic HIV-1 to enter cells. Option D: It inhibits the increase in promoter activity observed following overexpression of PKCdelta, constitutively active Ras, or MEKK1. " A 3385 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=O)NC(=O)N1)F Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It inhibits acetylcholinesterase. Option B: It acts by inhibition of cholinesterase activity. Option C: It inhibits cholinesterase enzyme. Option D: It inhibits DNA synthesis by blocking the conversion of deoxyuridylic acid to thymidylic acid. " D 135411330 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC(=N2)/C=C/C3=CC=CC=C3O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. Option B: It exerts a dose-dependent antagonism of the cysteinyl leukotriene pathway, preferentially antagonizing cysteinyl leukotriene receptor 1. Option C: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity. Option D: It exerts a dose-dependent antagonism of the cysteinyl leukotriene pathway and preferentially antagonizes cysteinyl leukotriene receptor 1. " D 11363812 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CCC3=C([C@@]1(CC[C@@H]2[C@@H](CC[C@@H](C(C)(C)O)O)C(=O)O)C)CC[C@@H]4[C@@]3(CCC(=O)C4(C)C)C Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It exhibits antiinflammatory activity against cylooxygenase-1 (COX-1) and cylooxygenase-2 (COX-2). Option B: It exhibits the action of mediating at least some of its immunomodulatory actions via inhibition of cyclic adenosine monophosphate (cAMP)-phosphodiesterase (PDE), and consequential increase in intracellular cAMP concentrations. Option C: It has multiple actions, including activating GABA(B) receptors, enhancing NMDA current, blocking AMPA-receptor-mediated transmission, binding to the L-alpha-amino acid transporter, activating ATP-sensitive K(+) channels, activating hyperpolarization-activated cation channels, and modulating Ca(2+) current. Option D: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity. " A 10796739 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CN=CC(=C1N)CO Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It competes with serotonin at receptor sites in smooth muscle. Option B: It causes relaxation of smooth muscle in blood vessels and the prostate. Option C: It has direct actions on blood vessels and increases cardiac output. Option D: It restores axonal conduction after spinal cord injury. " D 439530 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It interacts with 14-α demethylase. Option B: It causes premature chain termination during translation taking place in the ribosome. Option C: It interacts with 14-alpha demethylase. Option D: It inhibits DNA synthesis and interacts with SH groups. " B 2856102 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C1=C(NC(=C(C1C2=C(C(=C(C(=C2F)F)F)F)F)C(=O)OCC)C)C Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It is commonly associated with serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury. Option B: It exhibits the action of acting as an inhibitor of cholinesterase and being highly toxic by all routes of exposure. Option C: It induces a variety of defects including those affecting morphology and egg laying. Option D: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain. " C 1884 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC2=C(C=C1Cl)NC(=CC2=O)C(=O)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. Option B: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity. Option C: It has multiple actions, including activating GABA(B) receptors, enhancing NMDA current, blocking AMPA-receptor-mediated transmission, binding to the L-alpha-amino acid transporter, activating ATP-sensitive K(+) channels, activating hyperpolarization-activated cation channels, and modulating Ca(2+) current. Option D: It antagonizes the strychnine-insensitive glycine site of the NMDA receptor and prevents neurodegeneration produced by quinolinic acid. " D 6082 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C(C1=C(C=CC(=C1)OC)OC)O)N Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. Option B: It acts directly at alpha-adrenoceptors with selectivity for the alpha-1 adrenoceptor subtype similar to phenylephrine. Option C: It antagonizes the strychnine-insensitive glycine site of the NMDA receptor and prevents neurodegeneration produced by quinolinic acid. Option D: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity. " B 4497 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOC Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It acts particularly on cerebral circulation and is used for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm. Option B: It is used for the prevention and management of angina pectoris caused by coronary artery disease, but its onset of action is not rapid enough to offset an acute anginal episode. Option C: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. Option D: It antagonizes the strychnine-insensitive glycine site of the NMDA receptor and prevents neurodegeneration produced by quinolinic acid. " A 53355240 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1C[C@@H](OC(=O)[C@H]1C)[C@@H](C)[C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3CCC5=CC(=O)C=C[C@]45C)COC(=O)C Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It inhibits the accumulation of the pro-inflammatory iNOS protein. Option B: It exhibits the action of concentrating its anti-inflammatory action at the site of application due to being a privalate salt. Option C: It has vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions. Option D: It has cardiac stimulant action without evoking vasoconstriction or tachycardia. " A 135886618 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC(=N2)/C=C/C3=CC=CC=C3O.Cl Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity. Option B: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. Option C: It exerts a dose-dependent antagonism of the cysteinyl leukotriene pathway, preferentially antagonizing cysteinyl leukotriene receptor 1. Option D: It exerts a dose-dependent antagonism of the cysteinyl leukotriene pathway and preferentially antagonizes cysteinyl leukotriene receptor 1. " C 62920 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)O[C@@H]1[C@@H](SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It is an anti-arrhythmia drug and a sodium channel blocker. Option B: It acts as an L-type calcium channel blocker. Option C: It acts as an anti-inflammatory agent and antibiotic. Option D: It is a calcium-channel blocker and vasodilator. " D 132472361 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)/C(=N/P(=O)(OCC)F)/C Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It is an EC 3.1.1.7 (acetylcholinesterase) inhibitor and a neurotoxin. Option B: It binds irreversibly to acetylcholinesterase. Option C: It inhibits acetylcholinesterase. Option D: It inhibits cholinesterase enzyme. " A 46907787 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It exhibits antiplasmodial and antitrypanosomal activities. Option B: It acts as an anti-inflammatory agent and antibiotic. Option C: It has antioxidant and anti-proliferative effects. Option D: It exhibits anti-cancer and cardioprotective properties as an inhibitor of bromodomain-containing protein 4. " D 65832 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C(CCCN(C)CCC1=CC(=CC=C1)OC)(C#N)C2=CC(=C(C=C2)OC)OC Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It acts as an anti-inflammatory agent and antibiotic. Option B: It is an anti-arrhythmia drug and a sodium channel blocker. Option C: It acts as an L-type calcium channel blocker. Option D: It is a calcium-channel blocker and vasodilator. " C 8029 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=COC=C1 Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It interacts predominantly with the opioid mu-receptors. Option B: It allows one of the lone pairs of oxygen to reside in a p orbital and thus interact within the pi-system. Option C: It exhibits the action of markedly altering the intermediary metabolism of alcohol. Option D: It stabilizes the chemical balance in the brain disrupted by alcoholism. " B 5311065 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C[C@H](N(C1)C(=O)[C@@H]2CSSCCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(=O)N Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It inhibits the increase in promoter activity observed following overexpression of PKCdelta, constitutively active Ras, or MEKK1. Option B: It interacts with V1, V2 or V3 receptors with differing signal cascade systems. Option C: It acts as a potent and ATP-competitive inhibitor of VEGFR2/KDR, Flt3, and cKit. Option D: It mediates a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis. " B 4680 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C=C(C=C1)CC2=NC=CC3=CC(=C(C=C32)OC)OC)OC Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It can inhibit phosphodiesterases and may have direct actions on calcium channels. Option B: It can act on both N-type and L-type calcium channels. Option C: It exhibits the action of directly stimulating the uterine muscle to increase force and frequency of contractions. Option D: It has direct actions on blood vessels and increases cardiac output. " A 2719 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has a specific mode of action on insects. Option B: It may be at least partially involved in a certain action. Option C: The mechanism of its plasmodicidal action is not completely certain. Option D: Its effects are more intense and its duration of action is shorter. " C 65110 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC(=C(N1[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O)N)C(=O)N Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It interferes with bacterial protein synthesis. Option B: It inhibits DNA synthesis. Option C: It is capable of stimulating AMP-dependent protein kinase (AMPK) activity. Option D: It inhibits bacterial protein synthesis. " C 5371562 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C(=C\\C(=O)NC)/OP(=O)(OC)OC Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has systemic protective and curative action. Option B: It has curative, protective, and eradicant action. Option C: It has systemic protective, curative, and eradicant action. Option D: It works systemically and on contact as an organophosphorus insecticide and acaricide. " D 10680 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2=CC(=O)C3=CC=CC=C3O2 Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It inhibits both the manufacture and release of histamine and other allergic/inflammatory mediators. Option B: It interacts with various anti-anginal or anti-hypertensive agents to develop potentially rapid, excessive, and/or fatal hypotensive crises. Option C: It exhibits the action of having a delayed onset, narrow therapeutic window, need for regular monitoring and INR testing, and numerous drug-drug and drug-food interactions, which limits its effective use for stroke prevention. Option D: It is used for the prevention and management of angina pectoris caused by coronary artery disease, but its onset of action is not rapid enough to offset an acute anginal episode. " A 4055 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=O)C2=CC=CC=C2C1=O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: Its supplements have been banned by the FDA because of their high toxicity. Option B: It has direct actions on blood vessels and increases cardiac output. Option C: It is commonly associated with serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury. Option D: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain. " A 151166 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=C(C=C1)NC2=C(C=CC=C2Cl)F)CC(=O)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has direct actions on blood vessels and increases cardiac output. Option B: It may cause liver failure. Option C: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain. Option D: It causes relaxation of smooth muscle in blood vessels and the prostate. " B 2733526 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC/C(=C(\\C1=CC=CC=C1)/C2=CC=C(C=C2)OCCN(C)C)/C3=CC=CC=C3 Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity. Option B: It has multiple actions, including activating GABA(B) receptors, enhancing NMDA current, blocking AMPA-receptor-mediated transmission, binding to the L-alpha-amino acid transporter, activating ATP-sensitive K(+) channels, activating hyperpolarization-activated cation channels, and modulating Ca(2+) current. Option C: It exhibits the action of mediating at least some of its immunomodulatory actions via inhibition of cyclic adenosine monophosphate (cAMP)-phosphodiesterase (PDE), and consequential increase in intracellular cAMP concentrations. Option D: It interacts with other coactivators or corepressors in the tissue and binds with different estrogen receptors, ER-alpha or ER-beta. " D 25154714 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[C@@H](C(=O)N1CCC[C@H]1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)[C@@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)OC)NC(=O)OC Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. Option B: It prevents RNA replication and virion assembly via binding to NS5A, a nonstructural phosphoprotein encoded by HCV. Option C: It has systemic protective, curative, and eradicant action. Option D: It has cardiac stimulant action without evoking vasoconstriction or tachycardia. " B 2266 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCCC(=O)O)CCCC(=O)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It inhibits microbial cellular protein synthesis. Option B: It inhibits DNA synthesis. Option C: It interferes with bacterial protein synthesis. Option D: It inhibits bacterial protein synthesis. " A 24934 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-][Se](=O)[O-].[Na+].[Na+] Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain. Option B: It is very irritating to skin and mucous membranes and has keratolytic actions. Option C: It cancels out the green color imparted by iron impurities. Option D: It undergoes biotransformation to form the active moiety for antifungal actions. " C 2833 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It causes premature chain termination during translation taking place in the ribosome. Option B: It interacts with 14-alpha demethylase. Option C: It may be at least partially involved in a certain action. Option D: It inhibits DNA synthesis and interacts with SH groups. " C 34328 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(CCC1(C2=CC=CC=C2)C(=O)O)CCC(C#N)(C3=CC=CC=C3)C4=CC=CC=C4 Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It first acts on the mu-opioid receptors. Option B: It activates opioid receptors in the intestine. Option C: It selectively inhibits mitosis and cell division. Option D: It interacts predominantly with the opioid mu-receptors. " B 5281081 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)C(=O)/C(=C/C1=CC(=C(C(=C1)O)O)[N+](=O)[O-])/C#N Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has direct actions on blood vessels and increases cardiac output. Option B: It can inhibit phosphodiesterases and may have direct actions on calcium channels. Option C: It can act on both N-type and L-type calcium channels. Option D: It can increase and sustain plasma levodopa concentrations. " D 446157 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C1=NC(=NC(=C1/C=C/[C@H](C[C@H](CC(=O)O)O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has less risk of drug-drug interactions compared to certain other drugs. Option B: It has reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug interactions. Option C: It exhibits the action of having a delayed onset, narrow therapeutic window, need for regular monitoring and INR testing, and numerous drug-drug and drug-food interactions, which limits its effective use for stroke prevention. Option D: It exhibits the action of having a reduced propensity for involvement in drug-drug interactions owing to its primarily reductive metabolism. " A 5610 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CCN)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has cardiac stimulant action without evoking vasoconstriction or tachycardia. Option B: It exhibits the actions of being an extremely potent uncoupler of oxidative phosphorylation in mitochondria and having high reactivity with thiols. Option C: It can cause hypertensive crisis when ingested with tyramine-rich diet. Option D: It is used for the prevention and management of angina pectoris caused by coronary artery disease, but its onset of action is not rapid enough to offset an acute anginal episode. " C 2313 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)OCC(=O)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It inhibits the denaturation of proteins. Option B: It inhibits cell-wall biosynthesis. Option C: It selectively inhibits mitosis and cell division. Option D: It inhibits DNA synthesis. " A 5732 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)C2=C(N3C=C(C=CC3=N2)C)CC(=O)N(C)C Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has a rapid onset of action and short half-life. Option B: It works quickly and has a short half-life. Option C: It has a fast onset of action. Option D: It displays rapid absorption and onset of action with the shortest half-life and duration of action. " B 6579 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC(=O)N Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain. Option B: It is commonly associated with serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury. Option C: It may or may not have direct interaction with DNA for cancer induction. Option D: It has direct actions on blood vessels and increases cardiac output. " C 5284603 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)OC)O4)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It closes N-type voltage-operated calcium channels and opens calcium-dependent inwardly rectifying potassium channels. Option B: It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors and modulates chloride currents through receptor channels. Option C: It exhibits the actions of closing N-type voltage-operated calcium channels (OP2-receptor agonist) and opening calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). Option D: It does not affect calcium influx and does not antagonize the actions of calcium channel blockers. " A 115224 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CSC(=NC#N)N1CC2=CN=C(C=C2)Cl Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It inhibits acetylcholinesterase. Option B: It inhibits cholinesterase enzyme. Option C: It binds irreversibly to acetylcholinesterase. Option D: It cannot be broken down by acetylcholinesterase and the binding is irreversible. " D 104838 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]([C@@H]1[C@H]2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It stimulates activation of new platelets and increases platelet aggregation. Option B: Its effectiveness is enhanced when administered in combination with cilastatin. Option C: It mediates a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis. Option D: It inhibits the increase in promoter activity observed following overexpression of PKCdelta, constitutively active Ras, or MEKK1. " B 3869 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CCC1=CC=CC=C1)NCC(C2=CC(=C(C=C2)O)C(=O)N)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. Option B: It competitively blocks adrenergic stimulation of β-receptors and α1-receptors. Option C: It acts directly at alpha-adrenoceptors with selectivity for the alpha-1 adrenoceptor subtype similar to phenylephrine. Option D: It has cardiac stimulant action without evoking vasoconstriction or tachycardia. " B 6099959 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Mg+2].[Mg+2].[Mg+2] Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has a fast onset of action. Option B: It works primarily through the high osmolarity of the solution. Option C: It has a slow onset of action and exhibits a ""ceiling effect"". Option D: It has a rapid onset of action and short half-life. " B 68617 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN[C@H]1CC[C@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has little to no effect on norepinephrine or dopamine reuptake and does not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. Option B: It has little to no effect on norepinephrine or dopamine reuptake and does not antagonize α- or β-adrenergic, dopamine D2, or histamine H1 receptors. Option C: It does not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. Option D: It acts as an excitotoxin on glutamate receptors such as NMDA, calcium dependent AMPA and kainite receptors. " C 991 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OC1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It inhibits acetylcholinesterase. Option B: It inhibits cholinesterase enzyme. Option C: It acts as an inhibitor of cholinesterase. Option D: It acts by inhibition of cholinesterase activity. " C 36811 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CCC1=CC=C(C=C1)O)NCCC2=CC(=C(C=C2)O)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It mediates a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis. Option B: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. Option C: It has cardiac stimulant action without evoking vasoconstriction or tachycardia. Option D: It is used for the prevention and management of angina pectoris caused by coronary artery disease, but its onset of action is not rapid enough to offset an acute anginal episode. " C 4054 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC12CC3CC(C1)(CC(C3)(C2)N)C Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has systemic protective, curative, and eradicant action. Option B: It has curative, protective, and eradicant action. Option C: It is a highly potent, competitive, preferential dopamine D3 receptor antagonist, centrally active upon systemic administration. Option D: It is a noncompetitive NMDA receptor antagonist. " D 45375808 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3 Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It inhibits DNA synthesis. Option B: It acts as a defective substrate for NS5B. Option C: It inhibits bacterial protein synthesis. Option D: It interferes with bacterial protein synthesis. " B 4096 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=O)(N)SC Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It inhibits cholinesterase enzyme. Option B: It inhibits acetylcholinesterase. Option C: It acts by inhibition of cholinesterase activity. Option D: It binds irreversibly to acetylcholinesterase. " B 4506 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3 Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It acts as a selective agonist for the retinoic acid receptors (RAR). Option B: It acts as an agonist to the GABA receptors. Option C: It enhances the binding of GABA to GABAA receptors. Option D: It does not interact with GABA receptors. " C 2756 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(N=CN1)CSCCNC(=NC)NC#N Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It mediates a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis. Option B: It inhibits the increase in promoter activity observed following overexpression of PKCdelta, constitutively active Ras, or MEKK1. Option C: It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors and modulates chloride currents through receptor channels. Option D: It inhibits gastric acid secretion, pepsin, and gastrins output. " D 2942 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)N=NC1=C(NC=N1)C(=O)N Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It interacts with 14-alpha demethylase. Option B: It interacts with 14-α demethylase. Option C: It inhibits DNA synthesis and interacts with SH groups. Option D: It causes premature chain termination during translation taking place in the ribosome. " C 7955 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=NC(=NC(=N1)N)N)N Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It causes kidney malfunction. Option B: It has direct actions on blood vessels and increases cardiac output. Option C: It causes relaxation of smooth muscle in blood vessels and the prostate. Option D: It may cause liver failure. " A 3346 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CC(=C1)OP(=S)(OC)OC)SC Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It inhibits cholinesterase enzyme. Option B: It acts by inhibition of cholinesterase activity. Option C: It binds irreversibly to acetylcholinesterase. Option D: It inhibits acetylcholinesterase. " A 5284596 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain. Option B: It has direct actions on blood vessels and increases cardiac output. Option C: It acts within three to five minutes. Option D: It causes relaxation of smooth muscle in blood vessels and the prostate. " C 135398744 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. Option B: It exhibits the action of having a delayed onset, narrow therapeutic window, need for regular monitoring and INR testing, and numerous drug-drug and drug-food interactions, which limits its effective use for stroke prevention. Option C: It interacts with various anti-anginal or anti-hypertensive agents to develop potentially rapid, excessive, and/or fatal hypotensive crises. Option D: It is used for the prevention and management of angina pectoris caused by coronary artery disease, but its onset of action is not rapid enough to offset an acute anginal episode. " C 10607 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC(=CC(=C1OC)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@H](C4=CC5=C(C=C24)OCO5)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It is very irritating to skin and mucous membranes and has keratolytic actions. Option B: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain. Option C: It is commonly associated with serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury. Option D: It induces a variety of defects including those affecting morphology and egg laying. " A 43226 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)(C3=CN=CN=C3)O)Cl Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It inhibits bacterial protein synthesis. Option B: It inhibits the fungus's biosynthesis of important steroid molecules. Option C: It inhibits microbial cellular protein synthesis. Option D: It interferes with bacterial protein synthesis. " B 5280961 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It works primarily through the high osmolarity of the solution. Option B: It has a slow onset of action and exhibits a ""ceiling effect"". Option C: It directly stimulates the plasma membrane-associated adenylate cyclases. Option D: It has a fast onset of action. " C 774 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(NC=N1)CCN Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has multiple actions, including activating GABA(B) receptors, enhancing NMDA current, blocking AMPA-receptor-mediated transmission, binding to the L-alpha-amino acid transporter, activating ATP-sensitive K(+) channels, activating hyperpolarization-activated cation channels, and modulating Ca(2+) current. Option B: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. Option C: It exhibits the action of mediating at least some of its immunomodulatory actions via inhibition of cyclic adenosine monophosphate (cAMP)-phosphodiesterase (PDE), and consequential increase in intracellular cAMP concentrations. Option D: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity. " B 9411 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C)N1C(=O)C(=C(NC1=O)C)Br Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain. Option B: It exhibits the action of interfering with photosynthesis by entering the plant through the root zone and moving throughout the plant. Option C: It exhibits the action of interfering with mitotic division through contact. Option D: It undergoes biotransformation to form the active moiety for antifungal actions. " B 441397 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)OC(C)OC(=O)[C@H]1C(S[C@H]2N1C(=O)[C@H]2NC(=O)[C@@H](C3=CC=CC=C3)N)(C)C Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. Option B: It exhibits the action of exerting a bactericidal action through the inhibition of the biosynthesis of cell wall mucopeptides. Option C: It exhibits the action of acting as an inhibitor of cholinesterase and being highly toxic by all routes of exposure. Option D: It exhibits the actions of being an extremely potent uncoupler of oxidative phosphorylation in mitochondria and having high reactivity with thiols. " B 5284371 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@H](C=C4)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It acts as an excitotoxin on glutamate receptors such as NMDA, calcium dependent AMPA and kainite receptors. Option B: It has multiple actions, including activating GABA(B) receptors, enhancing NMDA current, blocking AMPA-receptor-mediated transmission, binding to the L-alpha-amino acid transporter, activating ATP-sensitive K(+) channels, activating hyperpolarization-activated cation channels, and modulating Ca(2+) current. Option C: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity. Option D: It exhibits the actions of closing N-type voltage-operated calcium channels (OP2-receptor agonist) and opening calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). " D 16490 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C)F Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It exhibits the action of acting as an inhibitor of cholinesterase and being highly toxic by all routes of exposure. Option B: It exhibits the actions of being an extremely potent uncoupler of oxidative phosphorylation in mitochondria and having high reactivity with thiols. Option C: It exhibits the action of concentrating its anti-inflammatory action at the site of application due to being a privalate salt. Option D: It is used for the prevention and management of angina pectoris caused by coronary artery disease, but its onset of action is not rapid enough to offset an acute anginal episode. " C 2519 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C=NC2=C1C(=O)N(C(=O)N2C)C Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity. Option B: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. Option C: It has multiple actions, including activating GABA(B) receptors, enhancing NMDA current, blocking AMPA-receptor-mediated transmission, binding to the L-alpha-amino acid transporter, activating ATP-sensitive K(+) channels, activating hyperpolarization-activated cation channels, and modulating Ca(2+) current. Option D: It exhibits the action of mediating at least some of its immunomodulatory actions via inhibition of cyclic adenosine monophosphate (cAMP)-phosphodiesterase (PDE), and consequential increase in intracellular cAMP concentrations. " D 91731 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=NC(=C1Cl)NC2=C(C=C(C(=C2[N+](=O)[O-])Cl)C(F)(F)F)[N+](=O)[O-])C(F)(F)F Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It is used for the prevention and management of angina pectoris caused by coronary artery disease, but its onset of action is not rapid enough to offset an acute anginal episode. Option B: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. Option C: It exhibits the action of having a delayed onset, narrow therapeutic window, need for regular monitoring and INR testing, and numerous drug-drug and drug-food interactions, which limits its effective use for stroke prevention. Option D: It exhibits the actions of being an extremely potent uncoupler of oxidative phosphorylation in mitochondria and having high reactivity with thiols. " D 3117 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)C(=S)SSC(=S)N(CC)CC Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It causes relaxation of smooth muscle in blood vessels and the prostate. Option B: It exhibits the action of directly stimulating the uterine muscle to increase force and frequency of contractions. Option C: It has direct actions on blood vessels and increases cardiac output. Option D: It exhibits the action of markedly altering the intermediary metabolism of alcohol. " D 443884 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](CO)NC(=O)[C@H]1CN([C@@H]2CC3=CNC4=CC=CC(=C34)C2=C1)C Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It exhibits the action of directly stimulating the uterine muscle to increase force and frequency of contractions. Option B: It has direct actions on blood vessels and increases cardiac output. Option C: It causes relaxation of smooth muscle in blood vessels and the prostate. Option D: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain. " A 6267 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@@H](C(=O)O)N)C(=O)N Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It exhibits the actions of being an extremely potent uncoupler of oxidative phosphorylation in mitochondria and having high reactivity with thiols. Option B: It exhibits the action of capping the hydrogen bond interactions which would otherwise need to be satisfied by the polypeptide backbone. Option C: It has cardiac stimulant action without evoking vasoconstriction or tachycardia. Option D: It has vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions. " B 19395 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OP(=S)(OCC)OCC Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It is used for the prevention and management of angina pectoris caused by coronary artery disease, but its onset of action is not rapid enough to offset an acute anginal episode. Option B: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. Option C: It exhibits the actions of being an extremely potent uncoupler of oxidative phosphorylation in mitochondria and having high reactivity with thiols. Option D: It exhibits the action of acting as an inhibitor of cholinesterase and being highly toxic by all routes of exposure. " D 31236 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)OCCO Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It exhibits the action of causing respiratory depression in infants when combined with Chlorphenesin. Option B: Its effectiveness is enhanced when administered in combination with cilastatin. Option C: It antagonizes cyclopamine action at the Smo receptor and activates the Hedgehog signaling pathway in a Patched independent manner. Option D: It has cardiac stimulant action without evoking vasoconstriction or tachycardia. " A 2431 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[N+](C)(C)CC1=CC=CC=C1Br Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has direct actions on blood vessels and increases cardiac output. Option B: It can inhibit phosphodiesterases and may have direct actions on calcium channels. Option C: It exhibits the action of inhibiting voltage-gated K(+) channels. Option D: It exhibits the action of directly stimulating the uterine muscle to increase force and frequency of contractions. " C 1018 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=NC(=C1)C(=O)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It can inhibit phosphodiesterases and may have direct actions on calcium channels. Option B: It has direct actions on blood vessels and increases cardiac output. Option C: It exhibits the action of binding to zinc finger proteins (ZFPs) in a way that changes their structures and disrupts zinc binding, inhibiting function. Option D: It exhibits the action of directly stimulating the uterine muscle to increase force and frequency of contractions. " C 5282181 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](CCCC(C)C)[C@H]1CC[C@@H]\\2[C@@]1(CCC/C2=C\\C=C/3\\C[C@H](C[C@@H](C3=C)O)O)C Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It is used for the prevention and management of angina pectoris caused by coronary artery disease, but its onset of action is not rapid enough to offset an acute anginal episode. Option B: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. Option C: It exhibits the action of having prolonged pharmacological actions compared to vitamin D due to a negative feedback mechanism regulating the final activation step of vitamin D in the kidneys. Option D: It exhibits the action of having a delayed onset, narrow therapeutic window, need for regular monitoring and INR testing, and numerous drug-drug and drug-food interactions, which limits its effective use for stroke prevention. " C 6720 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=C(C(=C(C(=C1Cl)Cl)Cl)Cl)Cl)[N+](=O)[O-] Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It exhibits the action of interfering with photosynthesis by entering the plant through the root zone and moving throughout the plant. Option B: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain. Option C: It exhibits the action of interfering with mitotic division through contact. Option D: It undergoes biotransformation to form the active moiety for antifungal actions. " C 3676 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CC(=O)NC1=C(C=CC=C1C)C Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has a fast onset of action. Option B: It has slower onsets and longer durations of action. Option C: Its effects are more intense and its duration of action is shorter. Option D: It has a slow onset of action and exhibits a ""ceiling effect"". " C 5504 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN=C(N1)CC2=CC=CC=C2 Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It causes relaxation of smooth muscle in blood vessels and the prostate. Option B: It is commonly associated with serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury. Option C: It has direct actions on blood vessels and increases cardiac output. Option D: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain. " C 3690 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(P(=O)(OC1)NCCCl)CCCl Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has a slow onset of action and exhibits a ""ceiling effect"". Option B: It has a fast onset of action. Option C: It primarily acts through the alkylation of DNA. Option D: It works primarily through the high osmolarity of the solution. " C 8607 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=O)N(C2=O)SC(Cl)(Cl)Cl Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It inhibits cell-wall biosynthesis. Option B: It inhibits normal cell division of microorganisms. Option C: It has a direct cytotoxic effect on microorganisms and cancer cells. Option D: It selectively inhibits mitosis and cell division. " B 702 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCO Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It does not interact with GABA receptors. Option B: It enhances the binding of GABA to GABAA receptors. Option C: It acts as an agonist to the GABA receptors. Option D: It acts as a selective agonist for the retinoic acid receptors (RAR). " C 25419 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(P(=O)(O)O)(P(=O)(O)O)(Cl)Cl Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It selectively inhibits mitosis and cell division. Option B: It affects mineralized tissues, especially bone. Option C: It inhibits cell-wall biosynthesis. Option D: It suppresses inflammation and stimulates cell-mediated immunity. " B 2771 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has little to no effect on norepinephrine or dopamine reuptake and does not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. Option B: It acts as an excitotoxin on glutamate receptors such as NMDA, calcium dependent AMPA and kainite receptors. Option C: It does not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. Option D: It has little to no effect on norepinephrine or dopamine reuptake and does not antagonize α- or β-adrenergic, dopamine D2, or histamine H1 receptors. " D 5288826 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](C=C4)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has an antagonist action on the 5-HT3 receptors. Option B: It first acts on the mu-opioid receptors. Option C: It interacts predominantly with the opioid mu-receptors. Option D: It does not interact with GABA receptors. " B 5569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN(CCC)C1=C(C=C(C=C1[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-] Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It suppresses inflammation and stimulates cell-mediated immunity. Option B: It inhibits cell-wall biosynthesis. Option C: It selectively inhibits mitosis and cell division. Option D: It inhibits DNA synthesis. " C 444 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It appears to block dopamine uptake. Option B: It can increase and sustain plasma levodopa concentrations. Option C: It has direct actions on blood vessels and increases cardiac output. Option D: It has dopaminergic effects. " A 2764 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It inhibits the enzymes topoisomerase II and topoisomerase IV. Option B: It inhibits the denaturation of proteins. Option C: It selectively inhibits mitosis and cell division. Option D: It inhibits cell-wall biosynthesis. " A 5280443 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. Option B: It mediates a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis. Option C: It inhibits the increase in promoter activity observed following overexpression of PKCdelta, constitutively active Ras, or MEKK1. Option D: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity. " C 3365 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It interacts with 14-α demethylase. Option B: It interacts with 14-alpha demethylase, a cytochrome P-450 enzyme. Option C: It interacts with 14-alpha demethylase. Option D: It interacts with 14-α demethylase, a cytochrome P-450 enzyme. " D 3386 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has little to no effect on norepinephrine or dopamine reuptake and does not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. Option B: It does not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. Option C: It acts as an excitotoxin on glutamate receptors such as NMDA, calcium dependent AMPA and kainite receptors. Option D: It has little to no effect on norepinephrine or dopamine reuptake and does not antagonize α- or β-adrenergic, dopamine D2, or histamine H1 receptors. " D 2197 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC=C(C=C1)C2C(=O)C3=CC=CC=C3C2=O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It exhibits the action of having prolonged pharmacological actions compared to vitamin D due to a negative feedback mechanism regulating the final activation step of vitamin D in the kidneys. Option B: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. Option C: It mediates a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis. Option D: It inhibits the vitamin K-mediated gamma-carboxylation of precursor proteins. " D 70788951 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[PH+](CC)CC.CC(=O)OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)[S-])OC(=O)C)OC(=O)C)OC(=O)C.[Au] Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It inhibits cell-wall biosynthesis. Option B: It suppresses inflammation and stimulates cell-mediated immunity. Option C: It inhibits DNA synthesis. Option D: It selectively inhibits mitosis and cell division. " B 5284583 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@@H](C(=O)N)N1CCCC1=O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It possesses a wide therapeutic index and little-to-no potential to produce, or be subject to, pharmacokinetic interactions. Option B: It is used for the prevention and management of angina pectoris caused by coronary artery disease, but its onset of action is not rapid enough to offset an acute anginal episode. Option C: It exhibits the actions of being an extremely potent uncoupler of oxidative phosphorylation in mitochondria and having high reactivity with thiols. Option D: It exhibits the action of having a delayed onset, narrow therapeutic window, need for regular monitoring and INR testing, and numerous drug-drug and drug-food interactions, which limits its effective use for stroke prevention. " A 153909 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NC(=NC(=N1)OC)N(C)C(=O)NS(=O)(=O)C2=CC=CC=C2C(=O)OC Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It binds irreversibly to acetylcholinesterase. Option B: It cannot be broken down by acetylcholinesterase and the binding is irreversible. Option C: It acts on acetolactate synthase (ALS), an enzyme involved in branched-chain amino acid biosynthesis. Option D: It inhibits acetylcholinesterase. " C 213021 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=NC#N)N(C)CC1=CN=C(C=C1)Cl Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It inhibits acetylcholinesterase. Option B: It acts by inhibition of cholinesterase activity. Option C: It inhibits cholinesterase enzyme. Option D: It binds irreversibly to acetylcholinesterase. " D 25474 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C2C(=C3C=C(C(=O)C(=C3OC2=C(C(=C1I)O)I)I)I)C4=C(C(=C(C(=C4Cl)Cl)Cl)Cl)C(=O)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It inhibits cell-wall biosynthesis. Option B: It has a direct cytotoxic effect on microorganisms and cancer cells. Option C: It inhibits normal cell division of microorganisms. Option D: It selectively inhibits mitosis and cell division. " B 71815 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NC=C(N1CC(C)O)[N+](=O)[O-] Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It can increase and sustain plasma levodopa concentrations. Option B: It can cause anterograde amnesia. Option C: It damages and kills the target pathogen by forming a radical anion. Option D: It acts as a transition state analogue for the hydrolysis of chloramphenicol esters. " C 3366 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC(=O)NC(=C1F)N Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. Option B: It antagonizes the strychnine-insensitive glycine site of the NMDA receptor and prevents neurodegeneration produced by quinolinic acid. Option C: It exhibits the actions of being an extremely potent uncoupler of oxidative phosphorylation in mitochondria and having high reactivity with thiols. Option D: It acts directly on fungal organisms by competitive inhibition of purine and pyrimidine uptake and indirectly by intracellular metabolism to 5-fluorouracil. " D 1030 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CO)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It specifically blocks necrosis downstream of the activation of RIP3, a key signaling molecule in the programmed necrosis (necroptosis) pathway. Option B: It inhibits release of tumor necrosis factor-alpha from monocytes and modulates other cytokine action. Option C: It stimulates activation of new platelets and increases platelet aggregation. Option D: It causes acute tubular necrosis. " D 11504295 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(CC1=CC=C(C=C1)OC)NC[C@@H](C2=C3C(=CC(=C2)O)NC(=O)CO3)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It mediates a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis. Option B: It mediates smooth muscle relaxation and bronchodilation. Option C: It stimulates activation of new platelets and increases platelet aggregation. Option D: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. " B 71158 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)NCCCS(=O)(=O)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It interacts predominantly with the opioid mu-receptors. Option B: It stabilizes the chemical balance in the brain disrupted by alcoholism. Option C: It exhibits the action of markedly altering the intermediary metabolism of alcohol. Option D: It exhibits the action of directly stimulating the uterine muscle to increase force and frequency of contractions. " B 6914 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1Cl)O)Cl)Cl Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It stimulates recovery of immunologic function in the lymphatic system after administration of antineoplastic agents or x-irradiation. Option B: It is commonly associated with serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury. Option C: It mediates a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis. Option D: It is carcinogenic, producing lymphomas, leukemia, and liver cancer. " D 5284569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3C(=O)CC4 Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It does not affect calcium influx and does not antagonize the actions of calcium channel blockers. Option B: It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors and modulates chloride currents through receptor channels. Option C: It exhibits the actions of closing N-type voltage-operated calcium channels (OP2-receptor agonist) and opening calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). Option D: It closes N-type voltage-operated calcium channels and opens calcium-dependent inwardly rectifying potassium channels. " D 29327 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO)O)O)N=O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It inhibits bacterial protein synthesis. Option B: It inhibits microbial cellular protein synthesis. Option C: It inhibits DNA synthesis. Option D: It interferes with bacterial protein synthesis. " C 23976 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Cr] Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It undergoes biotransformation to form the active moiety for antifungal actions. Option B: It exhibits the action of interfering with photosynthesis by entering the plant through the root zone and moving throughout the plant. Option C: It can co-ordinate, covalent interactions with macromolecules. Option D: It exhibits the action of interfering with mitotic division through contact. " C 14969 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@H]([C@@](C[C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)[C@H]([C@H](C(=O)N[C@H](C(=O)N[C@H]5C(=O)N[C@@H]7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)[C@H](NC(=O)[C@H]([C@@H](C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)[C@@H](CC(C)C)NC)O)Cl)CO)O)O)(C)N)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It inhibits cell-wall biosynthesis. Option B: It selectively inhibits mitosis and cell division. Option C: It suppresses inflammation and stimulates cell-mediated immunity. Option D: It inhibits DNA synthesis. " A 3198 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It causes premature chain termination during translation taking place in the ribosome. Option B: It interacts with 14-alpha demethylase. Option C: It inhibits DNA synthesis and interacts with SH groups. Option D: It interacts with 14-α demethylase. " B 3446 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(CC1)(CC(=O)O)CN Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity. Option B: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. Option C: It has multiple actions, including activating GABA(B) receptors, enhancing NMDA current, blocking AMPA-receptor-mediated transmission, binding to the L-alpha-amino acid transporter, activating ATP-sensitive K(+) channels, activating hyperpolarization-activated cation channels, and modulating Ca(2+) current. Option D: It exhibits the action of mediating at least some of its immunomodulatory actions via inhibition of cyclic adenosine monophosphate (cAMP)-phosphodiesterase (PDE), and consequential increase in intracellular cAMP concentrations. " C 6287 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[C@@H](C(=O)O)N Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has direct actions on blood vessels and increases cardiac output. Option B: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain. Option C: It competes with AAA for absorption into the brain. Option D: It causes relaxation of smooth muscle in blood vessels and the prostate. " C 3380 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C(=O)CN=C(C2=C1C=CC(=C2)[N+](=O)[O-])C3=CC=CC=C3F Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It releases endogenous estradiol. Option B: It may cause liver failure. Option C: It can increase and sustain plasma levodopa concentrations. Option D: It can cause anterograde amnesia. " D 33741 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C[C@H]1CCCC[C@@]1(C2=CC(=CC=C2)OC)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain. Option B: It is commonly associated with serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury. Option C: It has a dose-related risk of overdose, respiratory depression, and death. Option D: It has direct actions on blood vessels and increases cardiac output. " C 2812 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4 Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It exhibits the actions of being an extremely potent uncoupler of oxidative phosphorylation in mitochondria and having high reactivity with thiols. Option B: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. Option C: It exhibits the action of acting as an inhibitor of cholinesterase and being highly toxic by all routes of exposure. Option D: It is a potent, specific inhibitor of cytochrome P450 oxidase enzymes and may alter the metabolism of other drugs. " D 9429 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has no antiserotonin, hypotensive, or antihistaminic action. Option B: It interacts with various anti-anginal or anti-hypertensive agents to develop potentially rapid, excessive, and/or fatal hypotensive crises. Option C: It has little to no effect on norepinephrine or dopamine reuptake and does not antagonize α- or β-adrenergic, dopamine D2, or histamine H1 receptors. Option D: It has little to no effect on norepinephrine or dopamine reuptake and does not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. " A 43815 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4 Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has little to no effect on norepinephrine or dopamine reuptake and does not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. Option B: It has little to no effect on norepinephrine or dopamine reuptake and does not antagonize α- or β-adrenergic, dopamine D2, or histamine H1 receptors. Option C: It does not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. Option D: It acts as an excitotoxin on glutamate receptors such as NMDA, calcium dependent AMPA and kainite receptors. " B 5281077 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(/C=C/Cl)(C#C)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions. Option B: It exhibits the action of concentrating its anti-inflammatory action at the site of application due to being a privalate salt. Option C: It inhibits the accumulation of the pro-inflammatory iNOS protein. Option D: It increases the duration of time for which the Cl- ionopore is open. " D 3821 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC1(CCCCC1=O)C2=CC=CC=C2Cl Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It acts as an agonist to the GABA receptors. Option B: It acts as a selective agonist for the retinoic acid receptors (RAR). Option C: It does not interact with GABA receptors. Option D: It enhances the binding of GABA to GABAA receptors. " C 146570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCC[C@@]1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has little to no effect on norepinephrine or dopamine reuptake and does not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. Option B: It does not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. Option C: It acts as an excitotoxin on glutamate receptors such as NMDA, calcium dependent AMPA and kainite receptors. Option D: It has little to no effect on norepinephrine or dopamine reuptake and does not antagonize α- or β-adrenergic, dopamine D2, or histamine H1 receptors. " A 176870 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It acts as a potent and ATP-competitive inhibitor of VEGFR2/KDR, Flt3, and cKit. Option B: It mediates a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis. Option C: It inhibits the increase in promoter activity observed following overexpression of PKCdelta, constitutively active Ras, or MEKK1. Option D: It is a potent inhibitor of JAK2V617F. " D 5426 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It specifically blocks necrosis downstream of the activation of RIP3, a key signaling molecule in the programmed necrosis (necroptosis) pathway. Option B: It inhibits release of tumor necrosis factor-alpha from monocytes and modulates other cytokine action. Option C: It mediates a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis. Option D: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. " B 39186 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)O[C@@H]1[C@@H](SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions. Option B: It antagonizes cyclopamine action at the Smo receptor and activates the Hedgehog signaling pathway in a Patched independent manner. Option C: It has cardiac stimulant action without evoking vasoconstriction or tachycardia. Option D: It exhibits the actions of being an extremely potent uncoupler of oxidative phosphorylation in mitochondria and having high reactivity with thiols. " A 4485 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug interactions. Option B: It has slower onsets and longer durations of action. Option C: It has less risk of drug-drug interactions compared to certain other drugs. Option D: It has a dose-related risk of overdose, respiratory depression, and death. " B 44093 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](CS)C(=O)N1CCC[C@H]1C(=O)O Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It is a potent, specific inhibitor of cytochrome P450 oxidase enzymes and may alter the metabolism of other drugs. Option B: It is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE). Option C: It acts as a potent and ATP-competitive inhibitor of VEGFR2/KDR, Flt3, and cKit. Option D: It is a potent inhibitor of JAK2V617F. " B 3033621 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)C2=NC(C(=O)N(C3=C2C=C(C=C3)Cl)CCC#N)O)F Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It is a highly potent, competitive, preferential dopamine D3 receptor antagonist, centrally active upon systemic administration. Option B: It acts on various receptors, including certain histamine, serotonin, and adrenergic receptors. Option C: It binds to central benzodiazepine receptors which interact allosterically with GABA receptors. Option D: It has the potential for interaction with adrenergic and serotonergic agents. " C 182137 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN[C@@]1(CCCCC1=O)C2=CC=CC=C2Cl Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It has a fast onset of action. Option B: It has a slow onset of action and exhibits a ""ceiling effect"". Option C: It has a rapid onset of action and short half-life. Option D: It displays rapid absorption and onset of action with the shortest half-life and duration of action. " A 5284570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3C(=O)CC4 Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It does not interact with GABA receptors. Option B: It interacts predominantly with the opioid mu-receptors. Option C: It first acts on the mu-opioid receptors. Option D: It has an antagonist action on the 5-HT3 receptors. " B 105089 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC[C@@H](C(=O)O)N Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity. Option B: It acts as an excitotoxin on glutamate receptors such as NMDA, calcium dependent AMPA and kainite receptors. Option C: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. Option D: It has multiple actions, including activating GABA(B) receptors, enhancing NMDA current, blocking AMPA-receptor-mediated transmission, binding to the L-alpha-amino acid transporter, activating ATP-sensitive K(+) channels, activating hyperpolarization-activated cation channels, and modulating Ca(2+) current. " B 4189 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl Question about this molecule: Which kind of action does this molecule have/exhibit? Option A: It interacts with 14-alpha demethylase. Option B: It inhibits DNA synthesis and interacts with SH groups. Option C: It causes premature chain termination during translation taking place in the ribosome. Option D: It interacts with 14-α demethylase. " D 4054 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC12CC3CC(C1)(CC(C3)(C2)N)C Question about this molecule: Which kind of affinity does this molecule have/exhibit? Option A: It has a higher affinity to AR and no partial agonist activity compared to bicalutamide. Option B: It has low to moderate-affinity for NMDA receptors. Option C: It exhibits low to moderate affinity uncompetitive (open-channel) NMDA receptor antagonist activity. Option D: It has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors. " C 135564864 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NN(C(=O)N3)P(=O)(O)O)C4=CC=C(C=C4)F.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O Question about this molecule: Which kind of affinity does this molecule have/exhibit? Option A: It is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. Option B: It has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors. Option C: It is an antagonist of corticotropin-releasing factor 1 (CRF-1) receptors with a Ki of 1 nM. Option D: It has a high affinity for the mu-opioid receptor, but lower intrinsic activity compared to other full mu-opioid agonists. " A 181458 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl Question about this molecule: Which kind of affinity does this molecule have/exhibit? Option A: It has a higher affinity to AR and no partial agonist activity compared to bicalutamide. Option B: It has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors. Option C: It exhibits low to moderate affinity uncompetitive (open-channel) NMDA receptor antagonist activity. Option D: It has low to moderate-affinity for NMDA receptors. " C 297 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C Question about this molecule: Which kind of affinity does this molecule have/exhibit? Option A: It has a high affinity for heavy metals and proteins. Option B: It has a great affinity for water. Option C: It has a high affinity for bone mineral. Option D: It has a high affinity for various substances. " D 5707 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=CC=C1)C)NC2=NCCCS2 Question about this molecule: Which kind of affinity does this molecule have/exhibit? Option A: It has moderate affinity for histamine and alpha adrenergic receptors, and no appreciable affinity for cholinergic muscarinic receptors. Option B: It has a higher affinity to AR and no partial agonist activity compared to bicalutamide. Option C: Its affinity is lower than other α2 adrenergic receptor agonists. Option D: It has a high affinity for the mu-opioid receptor, but lower intrinsic activity compared to other full mu-opioid agonists. " C 6579 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC(=O)N Question about this molecule: Which kind of affinity does this molecule have/exhibit? Option A: It has an affinity for sulfhydryl groups on proteins. Option B: It has no significant affinity at GABA receptors. Option C: It has low to moderate-affinity for NMDA receptors. Option D: It has comparable affinity with calcitriol for the Vitamin D receptor. " A 4054 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC12CC3CC(C1)(CC(C3)(C2)N)C Question about this molecule: Which kind of affinity does this molecule have/exhibit? Option A: It has a higher affinity to AR and no partial agonist activity compared to bicalutamide. Option B: It has low to moderate-affinity for NMDA receptors. Option C: It exhibits low to moderate affinity uncompetitive (open-channel) NMDA receptor antagonist activity. Option D: It has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors. " B 5284596 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O Question about this molecule: Which kind of affinity does this molecule have/exhibit? Option A: It has a lower affinity for dopamine receptors. Option B: It has no significant affinity at GABA receptors. Option C: It has low to moderate-affinity for NMDA receptors. Option D: It has a high affinity for μ-opioid receptors. " D 2088 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN Question about this molecule: Which kind of affinity does this molecule have/exhibit? Option A: It has a high affinity for heavy metals and proteins. Option B: It has a high affinity for various substances. Option C: It has a high affinity for bone mineral. Option D: It has a great affinity for water. " C 3532 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CNCC(=C1)C(=O)O Question about this molecule: Which kind of affinity does this molecule have/exhibit? Option A: It exhibits low to moderate affinity uncompetitive (open-channel) NMDA receptor antagonist activity. Option B: It has no significant affinity at GABA receptors. Option C: It has low to moderate-affinity for NMDA receptors. Option D: It has a higher affinity to AR and no partial agonist activity compared to bicalutamide. " B 5862 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@@H](C(=O)O)N)S Question about this molecule: Which kind of affinity does this molecule have/exhibit? Option A: It has a high affinity for bone mineral. Option B: It has a great affinity for water. Option C: It has a high affinity for heavy metals and proteins. Option D: It has a high affinity for various substances. " C 5280793 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](/C=C/[C@H](C)C(C)C)[C@H]1CC[C@@H]\\2[C@@]1(CCC/C2=C\\C=C/3\\C[C@H](CCC3=C)O)C Question about this molecule: Which kind of affinity does this molecule have/exhibit? Option A: It has low to moderate-affinity for NMDA receptors. Option B: It has comparable affinity with calcitriol for the Vitamin D receptor. Option C: It has no significant affinity at GABA receptors. Option D: It has reduced affinity for the vitamin D binding protein. " D 33741 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C[C@H]1CCCC[C@@]1(C2=CC(=CC=C2)OC)O Question about this molecule: Which kind of affinity does this molecule have/exhibit? Option A: It has moderate affinity for histamine and alpha adrenergic receptors, and no appreciable affinity for cholinergic muscarinic receptors. Option B: It has a high affinity for the mu-opioid receptor, but lower intrinsic activity compared to other full mu-opioid agonists. Option C: It has a higher affinity to AR and no partial agonist activity compared to bicalutamide. Option D: The (+) enantiomer has higher affinity for the OP3 receptor. " D 1118 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OS(=O)(=O)O Question about this molecule: Which kind of affinity does this molecule have/exhibit? Option A: It has a high affinity for various substances. Option B: It has a high affinity for bone mineral. Option C: It has a great affinity for water. Option D: It has a high affinity for heavy metals and proteins. " C 135413536 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NNC(=O)N3)C4=CC=C(C=C4)F Question about this molecule: Which kind of affinity does this molecule have/exhibit? Option A: It has strong affinity to several dopaminergic receptors, but weak antagonism at the dopamine D2 receptor. Option B: It has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors. Option C: It has moderate affinity for histamine and alpha adrenergic receptors, and no appreciable affinity for cholinergic muscarinic receptors. Option D: It has a high affinity for the mu-opioid receptor, but lower intrinsic activity compared to other full mu-opioid agonists. " B 5707 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=CC=C1)C)NC2=NCCCS2 Question about this molecule: Which kind of agonist activity does this molecule have/exhibit? Option A: It acts as an agonist at α2 adrenoceptors. Option B: It is a potent agonist of the aryl hydrocarbon receptor. Option C: It has no partial agonist activity compared to bicalutamide. Option D: It is a very potent NMDA-receptor agonist. " A 4195 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC(=C(C=C1)OC)C(CNC(=O)CN)O Question about this molecule: Which kind of agonist activity does this molecule have/exhibit? Option A: It is an alpha-Adrenergic Agonist. Option B: It is an alpha-1 Adrenergic Agonist. Option C: It is a potent agonist of the aryl hydrocarbon receptor. Option D: It acts as an agonist at α2 adrenoceptors. " A 7028 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]([C@H](C1=CC=CC=C1)O)NC Question about this molecule: Which kind of agonist activity does this molecule have/exhibit? Option A: It is a potent agonist of the aryl hydrocarbon receptor. Option B: It is an alpha-Adrenergic Agonist. Option C: It acts as an agonist at α2 adrenoceptors. Option D: It is an alpha-1 Adrenergic Agonist. " B 6041 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC[C@@H](C1=CC(=CC=C1)O)O Question about this molecule: Which kind of agonist activity does this molecule have/exhibit? Option A: It is an alpha-Adrenergic Agonist. Option B: It is an alpha-1 Adrenergic Agonist. Option C: It is a potent agonist of the aryl hydrocarbon receptor. Option D: It acts as an agonist at α2 adrenoceptors. " B 644019 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC1=CC(=C(C(=C1)O)[C@@H]2C=C(CC[C@H]2C(=C)C)C)O Question about this molecule: Which kind of agonist activity does this molecule have/exhibit? Option A: It has no partial agonist activity compared to bicalutamide. Option B: It has weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors. Option C: It possesses potent agonist activity on dopamine D2 receptors. Option D: It is a very potent NMDA-receptor agonist. " B 54746 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@H]2[C@@H](CC3=CNC4=CC=CC2=C34)N(C1)CC=C Question about this molecule: Which kind of agonist activity does this molecule have/exhibit? Option A: It is a potent agonist of the aryl hydrocarbon receptor. Option B: It is a dopamine D2 agonist. Option C: It is a very potent NMDA-receptor agonist. Option D: It possesses potent agonist activity on dopamine D2 receptors. " D 115015 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@@H](C(=O)O)N)SS(=O)(=O)O Question about this molecule: Which kind of agonist activity does this molecule have/exhibit? Option A: It is a very potent NMDA-receptor agonist. Option B: It is a potent agonist of the aryl hydrocarbon receptor. Option C: It acts as an agonist at α2 adrenoceptors. Option D: It has no partial agonist activity compared to bicalutamide. " A 60815 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCC(=O)OC)C(=O)OC Question about this molecule: Which kind of agonist activity does this molecule have/exhibit? Option A: It is a very potent NMDA-receptor agonist. Option B: It is a specific mu-type-opioid receptor agonist. Option C: It is a potent agonist of the aryl hydrocarbon receptor. Option D: It acts as an agonist at α2 adrenoceptors. " B 25034024 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=C([C@@H](CO)O)C(=O)OC[C@@H]1[C@H]([C@@H]([C@H](C(O1)O)O)O)O Question about this molecule: Which kind of antibacterial activity does this molecule have/exhibit? Option A: It exhibits antibacterial properties. Option B: It exhibits potent antibacterial activity. Option C: It has a wide spectrum of antibacterial activity. Option D: It is a broad spectrum antibacterial drug. " B 2723 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC(=C1Cl)C)O Question about this molecule: Which kind of antibacterial activity does this molecule have/exhibit? Option A: It is more effective against certain Gram-negative bacteria. Option B: It is effective against many Gram-positive bacteria. Option C: It exhibits activity against Gram-positive bacteria. Option D: It is bactericidal against most Gram-positive bacteria. " D 2955 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)N Question about this molecule: Which kind of antibacterial activity does this molecule have/exhibit? Option A: It is more effective against certain Gram-negative bacteria. Option B: It is active against a wide range of bacteria. Option C: It is active against gram-positive bacteria. Option D: It is effective against many Gram-positive bacteria. " B 27447 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)[C@@H](C3=CC=CC=C3)N)SC1)C(=O)O Question about this molecule: Which kind of antibacterial activity does this molecule have/exhibit? Option A: It is active against both Gram-positive and Gram-negative bacteria. Option B: It is more effective against certain Gram-negative bacteria. Option C: It is effective against many Gram-positive bacteria. Option D: It is effective against both Gram-negative and Gram-positive organisms. " D 7099 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC2=NC3=C(C=CC(=C3)N)C=C21)N Question about this molecule: Which kind of antibacterial activity does this molecule have/exhibit? Option A: It is active against both Gram-positive and Gram-negative bacteria. Option B: It is effective against many Gram-positive bacteria. Option C: It exhibits activity against Gram-positive bacteria. Option D: It is more effective against certain Gram-negative bacteria. " B 5447130 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(OC(=C1)[N+](=O)[O-])/C=N/NC(=O)N Question about this molecule: Which kind of antibacterial activity does this molecule have/exhibit? Option A: It is a broad spectrum antibacterial drug. Option B: It has broad-spectrum antibacterial activity. Option C: It has a wide spectrum of antibacterial activity. Option D: It exhibits potent antibacterial activity. " A 10696525 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C/C=C/C=C/C(=O)NC1=C[C@]([C@H]2[C@@H](C1=O)O2)(/C=C/C=C/C=C/C(=O)NC3=C(CCC3=O)O)O Question about this molecule: Which kind of antibacterial activity does this molecule have/exhibit? Option A: It is effective against many Gram-positive bacteria. Option B: It exhibits antibacterial activity against Gram-negative bacteria. Option C: It shows weak antibacterial activity against certain strains. Option D: It exhibits activity against Gram-positive bacteria. " C 4539 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCNCC3)F)C(=O)O Question about this molecule: Which kind of antibacterial activity does this molecule have/exhibit? Option A: It is a broad spectrum antibacterial drug. Option B: It is a synthetic broad-spectrum antibacterial. Option C: It has broad-spectrum antibacterial activity. Option D: It has a wide spectrum of antibacterial activity. " C 5481173 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C(=O)O)O/N=C(/C1=CSC(=N1)N)\\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C[N+]4=CC=CC=C4)C(=O)[O-] Question about this molecule: Which kind of antibacterial activity does this molecule have/exhibit? Option A: It has broad-spectrum antibacterial activity. Option B: It is a broad spectrum antibacterial drug. Option C: It has a wide spectrum of antibacterial activity. Option D: It is a synthetic broad-spectrum antibacterial. " A 104838 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]([C@@H]1[C@H]2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O Question about this molecule: Which kind of antibacterial activity does this molecule have/exhibit? Option A: It has broad-spectrum antibacterial activity. Option B: It exhibits potent antibacterial activity. Option C: It is a broad spectrum antibacterial drug. Option D: It has a wide spectrum of antibacterial activity. " D 62959 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@@H]2[C@@H](C2N)CN1C3=C(C=C4C(=O)C(=CN(C4=N3)C5=C(C=C(C=C5)F)F)C(=O)O)F Question about this molecule: Which kind of antibacterial activity does this molecule have/exhibit? Option A: It has more activity against both gram-negative and gram-positive bacteria. Option B: It exhibits potent antibacterial activity against several Gram-positive bacterial strains. Option C: It exhibits antibacterial activity against bacterial vaginosis and candidiasis. Option D: It inhibits the uncoiling of supercoiled DNA in various bacteria. " D 7628 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: B(O)(O)O Question about this molecule: Which kind of antibacterial activity does this molecule have/exhibit? Option A: It exhibits antibacterial activity against bacterial vaginosis and candidiasis. Option B: It exhibits potent antibacterial activity against several Gram-positive bacterial strains. Option C: It exhibits antibacterial activity against Staphylococcus aureus. Option D: It has more activity against both gram-negative and gram-positive bacteria. " A 25233023 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C)/C=C/C1=CC2=C(C(=O)[C@@]3([C@H](C2=CO1)[C@H]4C(=O)O[C@@H]([C@H]([C@]4(O3)O)C)C)C)Cl Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit? Option A: It shows antifungal activity towards the pathogenic yeast Candida albicans. Option B: It shows antifungal activity against various human and phytophathogenic fungi. Option C: It exhibits antifungal activity against plant pathogenic fungi. Option D: It shows high antifungal activity against diseases caused by various pathogens. " C 46879407 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC/C=C/C(CC)CCC[C@]1(C[C@@H]([C@@H](OO1)CC(=O)O)CC)CC Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit? Option A: It is used for the control of soil, root and leaf diseases caused by oomycetes, particularly Phytophthora and Pythium species. Option B: It has broad-spectrum fungicidal and fungistatic activity against a number of yeasts and fungi, most notably Candida species. Option C: It exhibits antifungal activity against most of the Candida species, most Aspergillus species, Mucorales, Cryptococcus spp., Fusarium species, dermatophytes, and dimorphic fungi. Option D: It exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. " D 121596207 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=O)[C@]2([C@@H]([C@@H]1OC(=O)C)O2)C/C=C(\\C)/CC/C=C(\\C)/CC/C=C(\\C)/CO Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit? Option A: It shows antifungal activity against various human and phytophathogenic fungi. Option B: It exhibits antifungal activity against plant pathogenic fungi. Option C: It shows high antifungal activity against diseases caused by various pathogens. Option D: It shows antifungal activity towards the pathogenic yeast Candida albicans. " D 32490 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCOC(=O)NCCCN(C)C Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit? Option A: It displays potent broad-spectrum in vitro activity against dermatophytes, filamentous fungi and yeasts. Option B: It exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. Option C: It is used for the control of soil, root and leaf diseases caused by oomycetes, particularly Phytophthora and Pythium species. Option D: It has broad-spectrum fungicidal and fungistatic activity against a number of yeasts and fungi, most notably Candida species. " C 15910 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(#N)C1=C(C(=C(C(=C1Cl)Cl)Cl)C#N)Cl Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit? Option A: It displays potent broad-spectrum in vitro activity against dermatophytes, filamentous fungi and yeasts. Option B: It is used for the control of soil, root and leaf diseases caused by oomycetes, particularly Phytophthora and Pythium species. Option C: It is used to control a wide range of diseases including Aspergillus, Botrytis, Cladosporium and Fusarium. Option D: It is used to control a range of diseases in a wide variety of crops. " D 24796588 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC[C@@H]1[C@@H](C2=C(C=CC(=C2)OC)C(=O)O1)OC(=O)C Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit? Option A: It exhibits activity against dermatophyte fungi. Option B: It exhibits antifungal activity against plant pathogenic fungi. Option C: It shows antifungal activity against various human and phytophathogenic fungi. Option D: It shows antifungal activity towards the pathogenic yeast Candida albicans. " A 16682804 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)O[Sn](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3 Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit? Option A: It is used as a broad-spectrum antifungal drug. Option B: It is a broad spectrum antifungal agent. Option C: It acts as an antifungal and protein synthesis inhibitor. Option D: It has a role as an antifungal agrochemical. " D 121596210 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC/C(=C/CC/C(=C/C[C@]12[C@H](O1)[C@@H](C(=CC2=O)OC)O)/C)/C)C Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit? Option A: It shows high antifungal activity against diseases caused by various pathogens. Option B: It shows antifungal activity towards the pathogenic yeast Candida albicans. Option C: It exhibits antifungal activity against plant pathogenic fungi. Option D: It shows antifungal activity against various human and phytophathogenic fungi. " B 8330 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=C(C(=C1Cl)Cl)[N+](=O)[O-])Cl)Cl Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit? Option A: It is a broad spectrum antifungal agent. Option B: It is used as a broad-spectrum antifungal drug. Option C: It acts as an antifungal and protein synthesis inhibitor. Option D: It has a role as an antifungal agrochemical. " D 8204 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCN=C(N)N Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit? Option A: It is used as a broad-spectrum antifungal drug. Option B: It acts as an antifungal and protein synthesis inhibitor. Option C: It is a broad spectrum antifungal agent. Option D: It has a role as an antifungal agrochemical. " D 11057755 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C=C(C=C1)/C(=C/C(=O)N2CCOCC2)/C3=CC=C(C=C3)F)OC Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit? Option A: It acts as an antifungal and protein synthesis inhibitor. Option B: It is a broad spectrum antifungal agent. Option C: It has a role as an antifungal agrochemical. Option D: It is used as a broad-spectrum antifungal drug. " C 6328269 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=O)=O.CCOP(=O)=O.CCOP(=O)=O.[Al+3] Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit? Option A: It is used as a broad-spectrum antifungal drug. Option B: It has a role as an antifungal agrochemical. Option C: It acts as an antifungal and protein synthesis inhibitor. Option D: It is a broad spectrum antifungal agent. " B 17110 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCN=C(N)N.CC(=O)O Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit? Option A: It is a broad spectrum antifungal agent. Option B: It is used as a broad-spectrum antifungal drug. Option C: It acts as an antifungal and protein synthesis inhibitor. Option D: It has a role as an antifungal agrochemical. " D 6100711 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CNC(=S)[S-])NC(=S)[S-].[Zn+2] Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit? Option A: It acts as an antifungal and protein synthesis inhibitor. Option B: It is a broad spectrum antifungal agent. Option C: It has a role as an antifungal agrochemical. Option D: It is used as a broad-spectrum antifungal drug. " C 43234 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC1COC(O1)(CN2C=NC=N2)C3=C(C=C(C=C3)Cl)Cl Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit? Option A: It is used commercially as a diastereoisomeric mixture on soft fruit. Option B: It is a broad spectrum antifungal agent. Option C: It is used as a broad-spectrum antifungal drug. Option D: It has a role as an antifungal agrochemical. " A 44181993 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=O)N(C(=C1)CC(C)CC(C)(C)C)[O-].C(CO)[NH3+] Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit? Option A: It is used as a broad-spectrum antifungal drug. Option B: It is a broad spectrum antifungal agent. Option C: It has a role as an antifungal agrochemical. Option D: It is a hydroxypyridone antifungal drug. " D 50259 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=O)N(C(=C1)CC(C)CC(C)(C)C)O Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit? Option A: It is used as a broad-spectrum antifungal drug. Option B: It is a broad spectrum antifungal agent. Option C: It has a role as an antifungal agrochemical. Option D: It is a hydroxypyridone antifungal drug. " D 3401 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(C2=CC=C(C=C2)F)(C3=CC=CC=C3F)N4C=CN=C4 Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit? Option A: It has broad-spectrum fungicidal and fungistatic activity against a number of yeasts and fungi, most notably Candida species. Option B: It displays potent broad-spectrum in vitro activity against dermatophytes, filamentous fungi and yeasts. Option C: It induces oxidative stress in yeast and filamentous fungi. Option D: It shows antifungal activity against various human and phytophathogenic fungi. " B 72476 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=O)NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)[C@@H](C(=O)O)NC(=O)[C@H]([C@@H]([C@H](COC(=O)N)O)O)N)O)O)C(=O)O Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit? Option A: It is used as a broad-spectrum antifungal drug. Option B: It invades a fungus' ability to synthesize cell walls. Option C: It has a role as an EC 2.4.1.16 (chitin synthase) inhibitor. Option D: It is a broad spectrum antifungal agent. " C 2788 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC2=C(C(=C(C=C2Cl)I)O)N=C1 Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit? Option A: It is a broad spectrum antifungal agent. Option B: It has antibacterial and antifungal properties. Option C: It has a role as an antifungal agrochemical. Option D: It acts as an antifungal and protein synthesis inhibitor. " B 11486133 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C(=N\\OC)/C(=N\\OC)/C(=N/OCC1=CC=CC=C1/C(=N\\OC)/C(=O)NC)/C Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit? Option A: It exhibits antifungal activity against fluconazole-resistant yeast Candida glabrata. Option B: It shows antifungal activity towards the pathogenic yeast Candida albicans. Option C: It shows antifungal activity against various human and phytophathogenic fungi. Option D: It is an amide fungicide and a methoxyiminoacetamide strobilurin antifungal agent. " D 21141346 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC1=C(C=CC2=C1O[C@@H]3[C@H]2COC4=C3C=CC(=C4CC=C(C)C)O)O)C Question about this molecule: Which kind of antimicrobial activity does this molecule have/exhibit? Option A: It shows moderate antimicrobial activity against Bacillus subtilis. Option B: It exhibits antimycobacterial and antiplasmodial activities. Option C: It exhibits antibacterial, antimycobacterial, antiplasmodial, and cytotoxic activities. Option D: It exhibits strong and specific antimicrobial activities against rapid-growing Mycobacteria including drug-resistant strains. " C 53025 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C(=NN=N1)SCC2=C(N3[C@@H]([C@@](C3=O)(NC(=O)C4SC(=C(C(=O)N)C(=O)O)S4)OC)SC2)C(=O)O Question about this molecule: Which kind of antimicrobial activity does this molecule have/exhibit? Option A: It has in vitro activity against aerobic Gram-positive bacteria, certain Gram-negative bacteria, and anaerobic microorganisms. Option B: It is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms. Option C: It has a broad spectrum of activity against both gram-positive and gram-negative microorganisms. Option D: It is active against a broad spectrum of aerobic and anaerobic Gram-positive and Gram-negative microorganisms. " D 11594149 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCCC#CCCCCCCCCCCC(=O)O Question about this molecule: Which kind of antimicrobial activity does this molecule have/exhibit? Option A: It exhibits antimycobacterial and antiplasmodial activities. Option B: It exhibits strong and specific antimicrobial activities against rapid-growing Mycobacteria including drug-resistant strains. Option C: It shows moderate antimicrobial activity against Bacillus subtilis. Option D: It exhibits antibacterial, antimycobacterial, antiplasmodial, and cytotoxic activities. " A 4173 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NC=C(N1CCO)[N+](=O)[O-] Question about this molecule: Which kind of antimicrobial activity does this molecule have/exhibit? Option A: It exhibits moderate activity against Gram-positive bacteria. Option B: It has a broad spectrum of activity against Gram-positive organisms and a limited range of Gram-negative organisms. Option C: It is active against a broad spectrum of aerobic and anaerobic Gram-positive and Gram-negative microorganisms. Option D: It has activity against anaerobic bacteria and protozoa. " D 17757653 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)CCCCCC(C(=C)C(=O)O)C(=O)O Question about this molecule: Which kind of antimicrobial activity does this molecule have/exhibit? Option A: It has excellent activity against most aerobic gram-negative bacilli from the Enterobacteriaceae family, including Nocardia and some Mycobacterium. Option B: It is active against a wide range of micro-organisms including some fungi and viruses, but is only slowly effective against spores. Option C: It shows moderate antimicrobial activity against Bacillus subtilis. Option D: It exhibits strong and specific antimicrobial activities against rapid-growing Mycobacteria including drug-resistant strains. " C 43507 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)CC3=CC=CC=C3CN)C(=O)O)CSC4=NN=NN4CC(=O)O Question about this molecule: Which kind of antimicrobial activity does this molecule have/exhibit? Option A: It is active against Agrobacterium tumefaciens, Bacillus subtilis, Pseudomonas lachrymans, Ralstonia solanacearum, Staphylococcus hemolyticus, and Xanthomonas vesicatoria. Option B: It is effective against many coliforms, including Escherichia coli, Klebsiella, Enterobacter, and Proteus, and most strains of Salmonella, Shigella, Hemophilus, Citrobacter, and Arizona species. Option C: It has activity against Gram-positive cocci and rods, Gram-negative cocci, Legionellae, mycoplasmas, chlamydiae, some types of spirochetes, Toxoplasma gondii, and Cryptosporidium. Option D: It has excellent activity against most aerobic gram-negative bacilli from the Enterobacteriaceae family, including Nocardia and some Mycobacterium. " B 23668193 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: N(=O)[O-].[Na+] Question about this molecule: Which kind of antimicrobial activity does this molecule have/exhibit? Option A: It shows moderate antimicrobial activity against Bacillus subtilis. Option B: It exhibits antibacterial, antimycobacterial, antiplasmodial, and cytotoxic activities. Option C: It has a role as an antimicrobial food preservative. Option D: It exhibits strong and specific antimicrobial activities against rapid-growing Mycobacteria including drug-resistant strains. " C 5280440 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@@H]1[C@H](/C=C(/C=C/C(=O)[C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)O)C)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)O)(C)O)N(C)C)O)CC=O)C)\\C)CO[C@H]4[C@@H]([C@@H]([C@@H]([C@H](O4)C)O)OC)OC Question about this molecule: Which kind of antimicrobial activity does this molecule have/exhibit? Option A: It has in vitro activity against aerobic Gram-positive bacteria, certain Gram-negative bacteria, and anaerobic microorganisms. Option B: It has a broad spectrum of activity against Gram-positive organisms and a limited range of Gram-negative organisms. Option C: It is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms. Option D: It is active against a broad spectrum of aerobic and anaerobic Gram-positive and Gram-negative microorganisms. " B 12560 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)O)(C)O Question about this molecule: Which kind of antimicrobial activity does this molecule have/exhibit? Option A: It is active against a wide range of micro-organisms including some fungi and viruses, but is only slowly effective against spores. Option B: It has excellent activity against most aerobic gram-negative bacilli from the Enterobacteriaceae family, including Nocardia and some Mycobacterium. Option C: It is active against a broad spectrum of bacteria, fungi, moulds, and viruses. Option D: It may be bacteriostatic or bactericidal depending on the organism and drug concentration. " D 37768 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1NC(=O)[C@H](CCN)O)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)N)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CN)O)O)O)N Question about this molecule: Which kind of antimicrobial activity does this molecule have/exhibit? Option A: It is active against Agrobacterium tumefaciens, Bacillus subtilis, Pseudomonas lachrymans, Ralstonia solanacearum, Staphylococcus hemolyticus, and Xanthomonas vesicatoria. Option B: It has excellent activity against most aerobic gram-negative bacilli from the Enterobacteriaceae family, including Nocardia and some Mycobacterium. Option C: It has activity against Gram-positive cocci and rods, Gram-negative cocci, Legionellae, mycoplasmas, chlamydiae, some types of spirochetes, Toxoplasma gondii, and Cryptosporidium. Option D: It is effective against many coliforms, including Escherichia coli, Klebsiella, Enterobacter, and Proteus, and most strains of Salmonella, Shigella, Hemophilus, Citrobacter, and Arizona species. " B 996 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)O Question about this molecule: Which kind of antimicrobial activity does this molecule have/exhibit? Option A: It has excellent activity against most aerobic gram-negative bacilli from the Enterobacteriaceae family, including Nocardia and some Mycobacterium. Option B: It is active against a broad spectrum of bacteria, fungi, moulds, and viruses. Option C: It is active against a wide range of micro-organisms including some fungi and viruses, but is only slowly effective against spores. Option D: It has activity against Gram-positive cocci and rods, Gram-negative cocci, Legionellae, mycoplasmas, chlamydiae, some types of spirochetes, Toxoplasma gondii, and Cryptosporidium. " C 53025 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C(=NN=N1)SCC2=C(N3[C@@H]([C@@](C3=O)(NC(=O)C4SC(=C(C(=O)N)C(=O)O)S4)OC)SC2)C(=O)O Question about this molecule: Which kind of antimicrobial activity does this molecule have/exhibit? Option A: It is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms. Option B: It has a broad spectrum of activity against both gram-positive and gram-negative microorganisms. Option C: It is active against a broad spectrum of aerobic and anaerobic Gram-positive and Gram-negative microorganisms. Option D: It has in vitro activity against aerobic Gram-positive bacteria, certain Gram-negative bacteria, and anaerobic microorganisms. " A 5281702 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC(=CC(=C1O)OC)C2=CC(=O)C3=C(C=C(C=C3O2)O)O Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It inhibits tumor formation and growth by inhibiting LDH. Option B: It inhibits DNA synthesis and slows tumour growth. Option C: It specifically inhibits growth of renal cells in culture. Option D: It potently inhibits colon cancer cell growth. " D 10653928 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/CO)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It inhibits tumor formation and growth by inhibiting LDH. Option B: It inhibits the growth of Ehrlich ascites carcinoma in vitro. Option C: It specifically inhibits growth of renal cells in culture. Option D: It suppresses tumour growth by inhibiting the FGFR pathway. " C 443831 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)O)O)(C(=O)C)O)N)O Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It promotes caspase-dependent-apoptosis of leukemia cells. Option B: It induces cell cycle arrest and apoptosis in several human cancer cell lines. Option C: It has been found to induce apoptosis in HT-29 cells. Option D: It is an apoptosis inducer. " D 5372201 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CNC(=O)/C=C/C=C/CCCCC1=CC2=C(C=C1)OCO2 Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It induces apoptosis and possesses a significant in vivo effect against myeloma. Option B: It induces cell cycle arrest and apoptosis in several human cancer cell lines. Option C: It has been found to induce apoptosis in HT-29 cells. Option D: It promotes caspase-dependent-apoptosis of leukemia cells. " C 14259001 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC1=C2C(=C(C=C1O)O)C(=O)C[C@H](O2)C3=CC(=C(C=C3)OC)O)C Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It exhibits inhibitory efficacy against the growth of human tumour cells. Option B: It exhibits inhibitory activity against breast cancer resistance protein. Option C: It exhibits moderate cytotoxicity against several human tumour cell lines via specific apotopic cell death. Option D: It exhibits antiproliferative activity against A2780 human ovarian cancer cells. " B 5472495 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC\\1=C(C2=C(/C1=C\\C3=CC=C(C=C3)S(=O)(=O)C)C=CC(=C2)F)CC(=O)O Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It induces apoptosis in human malignant glioblastoma cells. Option B: It selectively inhibits survivin (BIRC5) gene promoter activity and down-regulates survivin in vitro, leading to induction of apoptosis. Option C: It induces apoptosis and possesses a significant in vivo effect against myeloma. Option D: It inhibits cell growth by inducing apoptosis independently of cyclooxygenase inhibition. " D 51041990 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC1=C(C=C(C=C1O)OC)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC)C Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It exhibits inhibitory efficacy against the growth of human tumour cells. Option B: It exhibits antiproliferative activity against A2780 human ovarian cancer cells. Option C: It exhibits inhibitory activity against breast cancer resistance protein. Option D: It exhibits moderate cytotoxicity against several human tumour cell lines via specific apotopic cell death. " C 3385 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=O)NC(=O)N1)F Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It potently inhibits colon cancer cell growth. Option B: It inhibits DNA synthesis and slows tumour growth. Option C: It specifically inhibits growth of renal cells in culture. Option D: It inhibits tumor formation and growth by inhibiting LDH. " B 42640846 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC[C@H](C)[C@@H]1CC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O1)CC2=CC=CC=C2)C)CC(C)C)C(C)C Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It inhibits the growth of A431 human epidermoid carcinoma and MKN-7 human stomach cancer cell lines. Option B: It selectively inhibits survivin (BIRC5) gene promoter activity and down-regulates survivin in vitro, leading to induction of apoptosis. Option C: It has potent anti-leukemic effects, inducing apoptosis in myeloid leukemia cell lines and primary AML cells at nanomolar concentrations. Option D: It blocks tumour necrosis factor (TNF)-induced activation of NFkappaB-Luc human embryonic kidney cells. " D 9796304 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCC/C=C\\CCCCCCC(C(=O)O)O Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It induces apoptosis in human malignant glioblastoma cells. Option B: It modulates the lipid content of cancer cell membranes and induces cell cycle arrest and apoptosis in several cancer cell lines. Option C: It induces cell cycle arrest and apoptosis in several human cancer cell lines. Option D: It inhibits the growth of A431 human epidermoid carcinoma and MKN-7 human stomach cancer cell lines. " B 51041756 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC/C(=C/CC1=C2C(=C(C=C1O)O)C(=O)C[C@H](O2)C3=CC(=CC(=C3)O)O)/C)C Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It exhibits moderate cytotoxicity against several human tumour cell lines via specific apotopic cell death. Option B: It exhibits inhibitory efficacy against the growth of human tumour cells. Option C: It exhibits antiproliferative activity against A2780 human ovarian cancer cells. Option D: It exhibits inhibitory activity against breast cancer resistance protein. " D 11354606 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@@H]2CC[C@H]3C(=C)C[C@@H](O3)CC[C@]45C[C@@H]6[C@H](O4)[C@H]7[C@@H](O6)[C@@H](O5)[C@@H]8[C@@H](O7)CC[C@@H](O8)CC(=O)C[C@H]9[C@H](C[C@H](C1=C)O2)O[C@@H]([C@@H]9OC)C[C@@H](CN)O Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It acts to stabilize microtubules, preventing mitosis and causing growth arrest in cancer cells. Option B: It has a role as an antineoplastic agent and a microtubule-destabilising agent. Option C: It induces cell cycle arrest and apoptosis in several human cancer cell lines. Option D: It exerts its effect by depolymerising microtubules. " B 639665 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC1=C(C(=C(C=C1O)OC)C(=O)/C=C/C2=CC=C(C=C2)O)O)C Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It selectively inhibits survivin (BIRC5) gene promoter activity and down-regulates survivin in vitro, leading to induction of apoptosis. Option B: It induces apoptosis and possesses a significant in vivo effect against myeloma. Option C: It induces apoptosis in human malignant glioblastoma cells. Option D: It has potent anti-leukemic effects, inducing apoptosis in myeloid leukemia cell lines and primary AML cells at nanomolar concentrations. " C 70697773 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCC/C=C(\\[C@@H](C(=O)C)O)/C(=O)OC Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It exhibits antiproliferative activity against A2780 human ovarian cancer cells. Option B: It exhibits moderate cytotoxicity against several human tumour cell lines via specific apotopic cell death. Option C: It exhibits apoptotic activity against human hepatoma hep G2 cells. Option D: It inhibits the growth of A431 human epidermoid carcinoma and MKN-7 human stomach cancer cell lines. " C 3994 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C1=CC=C(C=C1)C(=O)NCCCCCCC(=O)NO Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It inhibits the growth of A431 human epidermoid carcinoma and MKN-7 human stomach cancer cell lines. Option B: It induces cell cycle arrest and apoptosis in several human cancer cell lines. Option C: It modulates the lipid content of cancer cell membranes and induces cell cycle arrest and apoptosis in several cancer cell lines. Option D: It induces apoptosis in human malignant glioblastoma cells. " B 38347 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1COP(=O)(NC1OO)N(CCCl)CCCl Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It induces apoptosis and possesses a significant in vivo effect against myeloma. Option B: It has potent antineoplastic and immunosuppressive properties. Option C: It has antineoplastic activity and is used in the therapy of acute leukemia and AIDS related Kaposi sarcoma. Option D: It works against esophageal squamous cell carcinoma in vitro and in vivo. " B 54960 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC(=NC(=N1)NC(=O)NS(=O)(=O)CC2=CC=CC=C2C(=O)OC)OC Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It potently inhibits colon cancer cell growth. Option B: It stops cell division by inhibition of the acetolactate synthase enzyme. Option C: It specifically inhibits growth of renal cells in culture. Option D: It inhibits DNA synthesis and slows tumour growth. " B 6579 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC(=O)N Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It inhibits the growth of Ehrlich ascites carcinoma in vitro. Option B: It has been found to induce apoptosis in HT-29 cells. Option C: It induces a decrease in invasive activity of U87MG cells. Option D: It shows a decrease in cancer of the large bowel. " D 5280373 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC=C(C=C1)C2=COC3=CC(=CC(=C3C2=O)O)O Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It induces cell cycle arrest and apoptosis in several human cancer cell lines. Option B: It induces a decrease in invasive activity of U87MG cells. Option C: It has been found to induce apoptosis in HT-29 cells. Option D: It promotes caspase-dependent-apoptosis of leukemia cells. " B 60838 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7 Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It inhibits the growth of A431 human epidermoid carcinoma and MKN-7 human stomach cancer cell lines. Option B: It prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, causing double-strand DNA breakage and cell death. Option C: It exhibits broad spectrum activity against cultured tumor cell lines, including adriamycin-resistant HL-60 cells. Option D: It kills cancer cells by elevating oxidative stress levels beyond a breaking point, triggering programmed cell death. " B 30323 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It inhibits the growth of A431 human epidermoid carcinoma and MKN-7 human stomach cancer cell lines. Option B: It has antineoplastic activity and is used in the therapy of acute leukemia and AIDS related Kaposi sarcoma. Option C: It has potent anti-leukemic effects, inducing apoptosis in myeloid leukemia cell lines and primary AML cells at nanomolar concentrations. Option D: It works against esophageal squamous cell carcinoma in vitro and in vivo. " B 3385 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=O)NC(=O)N1)F Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. Option B: It induces apoptosis and possesses a significant in vivo effect against myeloma. Option C: It induces apoptosis in human malignant glioblastoma cells. Option D: It inhibits cell growth by inducing apoptosis independently of cyclooxygenase inhibition. " A 2244 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)OC1=CC=CC=C1C(=O)O Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It inhibits the growth of A431 human epidermoid carcinoma and MKN-7 human stomach cancer cell lines. Option B: It may decrease the risk of various cancers, including colorectal, esophageal, breast, lung, prostate, liver, and skin cancer. Option C: It is a potent inhibitor of carcinogenesis measured against chemical- or UV-initiated, phorbol-promoted mouse skin tumours. Option D: It has potent anti-leukemic effects, inducing apoptosis in myeloid leukemia cell lines and primary AML cells at nanomolar concentrations. " B 3305 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(O)(P(=O)(O)O)P(=O)(O)O Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It has potent anti-leukemic effects, inducing apoptosis in myeloid leukemia cell lines and primary AML cells at nanomolar concentrations. Option B: It is a potent inhibitor of carcinogenesis measured against chemical- or UV-initiated, phorbol-promoted mouse skin tumours. Option C: It inhibits the growth of A431 human epidermoid carcinoma and MKN-7 human stomach cancer cell lines. Option D: It reduces morbidity of osteolytic bone metastases by inhibiting tumour-induced bone resorption. " D 50259 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=O)N(C(=C1)CC(C)CC(C)(C)C)O Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It induces apoptosis in human malignant glioblastoma cells. Option B: It induces apoptosis and possesses a significant in vivo effect against myeloma. Option C: It selectively inhibits survivin (BIRC5) gene promoter activity and down-regulates survivin in vitro, leading to induction of apoptosis. Option D: It has potent anti-leukemic effects, inducing apoptosis in myeloid leukemia cell lines and primary AML cells at nanomolar concentrations. " B 5280443 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It inhibits the growth of A431 human epidermoid carcinoma and MKN-7 human stomach cancer cell lines. Option B: It induces cell cycle arrest and apoptosis in several human cancer cell lines. Option C: It promotes caspase-dependent-apoptosis of leukemia cells. Option D: It modulates the lipid content of cancer cell membranes and induces cell cycle arrest and apoptosis in several cancer cell lines. " C 10113978 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It induces apoptosis in human malignant glioblastoma cells. Option B: It induces apoptosis and possesses a significant in vivo effect against myeloma. Option C: It inhibits cell growth by inducing apoptosis independently of cyclooxygenase inhibition. Option D: It inhibits multiple protein tyrosine kinases with potential antineoplastic activity. " D 971 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(=O)O)O Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It specifically inhibits growth of renal cells in culture. Option B: It inhibits tumor formation and growth by inhibiting LDH. Option C: It inhibits the growth of Ehrlich ascites carcinoma in vitro. Option D: It suppresses tumour growth by inhibiting the FGFR pathway. " B 21704 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)O)N Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit? Option A: It has potent anti-leukemic effects, inducing apoptosis in myeloid leukemia cell lines and primary AML cells at nanomolar concentrations. Option B: It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the vaccinia VIRUS and varicella zoster virus. Option C: It selectively inhibits survivin (BIRC5) gene promoter activity and down-regulates survivin in vitro, leading to induction of apoptosis. Option D: It is a potent inhibitor of carcinogenesis measured against chemical- or UV-initiated, phorbol-promoted mouse skin tumours. " B 52945746 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C2C(=C(C(=C1OC)C=O)O)C(=O)C[C@H](O2)C3=CC=CC=C3 Question about this molecule: Which kind of antiviral activity does this molecule have/exhibit? Option A: It has potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. Option B: It exhibits inhibitory effects on the viral neuraminidases from two influenza viral strains, H1N1 and H9N2. Option C: It is used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients. Option D: It is used to treat influenza, herpes infection, viral hepatitis, acute respiratory viral infections, and SARS. " B 12132943 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C2=C(C(=C1OC)C=O)O[C@@H](CC2=O)C3=CC=CC=C3)O Question about this molecule: Which kind of antiviral activity does this molecule have/exhibit? Option A: It exhibits inhibitory effects on the viral neuraminidases from two influenza viral strains, H1N1 and H9N2. Option B: It is used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients. Option C: It is used to treat influenza, herpes infection, viral hepatitis, acute respiratory viral infections, and SARS. Option D: It has potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. " A 70697823 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC2=C(C=C1)OC[C@H]([C@@H]2OS(=O)(=O)[O-])C3=C(C(=CC(=C3)/C=C/C(=O)O)OC)O.[K+] Question about this molecule: Which kind of antiviral activity does this molecule have/exhibit? Option A: It exhibits antiviral activity against herpes simplex virus type 1. Option B: It displays effective antiviral activity against Herpes simplex virus type 1 and 2. Option C: It exhibits antiviral activity against many lipid enveloped viruses including herpes simplex virus (HSV). Option D: It exhibits antiviral activity against herpes simplex virus. " A 155165 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C=CC(=C1)CC[C@H](CC(=O)CCC2=CC=CC=C2)O)O Question about this molecule: Which kind of antiviral activity does this molecule have/exhibit? Option A: It exhibits antiviral activity against influenza A virus. Option B: It exhibits antiviral activity against influenza virus. Option C: It exhibits antiviral activity against herpes simplex virus. Option D: It exhibits activity against the influenza virus. " B 14753671 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=C(C2=C1OC(=CC2=O)C3=CC=CC=C3)OC)C)O Question about this molecule: Which kind of antiviral activity does this molecule have/exhibit? Option A: It exhibits inhibitory effects on the viral neuraminidases from two influenza viral strains, H1N1 and H9N2. Option B: It is used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients. Option C: It has potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. Option D: It is used to treat influenza, herpes infection, viral hepatitis, acute respiratory viral infections, and SARS. " A 49831445 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=C(C2=C1O[C@@](CC2=O)(C3=CC=CC=C3)O)OC)C)O Question about this molecule: Which kind of antiviral activity does this molecule have/exhibit? Option A: It has potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. Option B: It is used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients. Option C: It exhibits inhibitory effects on the viral neuraminidases from two influenza viral strains, H1N1 and H9N2. Option D: It is used to treat influenza, herpes infection, viral hepatitis, acute respiratory viral infections, and SARS. " C 10219 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@H]1CN2CCC3=CC(=C(C=C3[C@@H]2C[C@@H]1C[C@@H]4C5=CC(=C(C=C5CCN4)OC)OC)OC)OC Question about this molecule: Which kind of antiviral activity does this molecule have/exhibit? Option A: It exhibits inhibitory effects on the viral neuraminidases from two influenza viral strains, H1N1 and H9N2. Option B: It inhibits SARS-CoV2, Zika and Ebola virus replication. Option C: It is an inhibitor of SARS coronavirus main proteinase and inhibits SARS-CoV-2 replication in cell culture. Option D: It has potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. " B 11778601 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=C(C=C1O)OC)C(=O)/C=C/C2=CC=CC=C2)O Question about this molecule: Which kind of antiviral activity does this molecule have/exhibit? Option A: It is used to treat influenza, herpes infection, viral hepatitis, acute respiratory viral infections, and SARS. Option B: It is used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients. Option C: It exhibits inhibitory effects on the viral neuraminidases from two influenza viral strains, H1N1 and H9N2. Option D: It has potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. " C 49831446 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=C(C(=C1O)C(=O)/C=C/C2=CC=C(C=C2)O)OC)C)O Question about this molecule: Which kind of antiviral activity does this molecule have/exhibit? Option A: It is used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients. Option B: It is used to treat influenza, herpes infection, viral hepatitis, acute respiratory viral infections, and SARS. Option C: It exhibits inhibitory effects on the viral neuraminidases from two influenza viral strains, H1N1 and H9N2. Option D: It has potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. " C 60825 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@H](O[C@H](S1)CO)N2C=CC(=NC2=O)N Question about this molecule: Which kind of antiviral activity does this molecule have/exhibit? Option A: It exhibits antiviral activity against influenza A virus. Option B: It exhibits activity against the influenza virus. Option C: It exhibits antiviral activity against influenza virus. Option D: It is an inhibitor of HIV-1 reverse transcriptase. " D 180550 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=C2C(=C1O)C(=O)C[C@H](O2)C3=CC=CC=C3)C)O Question about this molecule: Which kind of antiviral activity does this molecule have/exhibit? Option A: It is used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients. Option B: It is used to treat influenza, herpes infection, viral hepatitis, acute respiratory viral infections, and SARS. Option C: It has potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. Option D: It exhibits inhibitory effects on the viral neuraminidases from two influenza viral strains, H1N1 and H9N2. " D 10424762 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=C(C(=C1O)C(=O)/C=C/C2=CC=CC=C2)OC)C)O Question about this molecule: Which kind of antiviral activity does this molecule have/exhibit? Option A: It is used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients. Option B: It is used to treat influenza, herpes infection, viral hepatitis, acute respiratory viral infections, and SARS. Option C: It has potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. Option D: It exhibits inhibitory effects on the viral neuraminidases from two influenza viral strains, H1N1 and H9N2. " D 60933 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CN(C(=O)N=C1N)C[C@@H](CO)OCP(=O)(O)O.O.O Question about this molecule: Which kind of antiviral activity does this molecule have/exhibit? Option A: It inhibits gene expression in HIV-1 at the transcriptional level through interference with Tat-mediated transactivation. Option B: It is used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients. Option C: It exhibits inhibitory effects on the viral neuraminidases from two influenza viral strains, H1N1 and H9N2. Option D: It has potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. " B 33958 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCOC1=CC2=C(C=C1)C3=C(C2=O)C=C(C=C3)OCCN(CC)CC.Cl.Cl Question about this molecule: Which kind of antiviral activity does this molecule have/exhibit? Option A: It is used to treat influenza, herpes infection, viral hepatitis, acute respiratory viral infections, and SARS. Option B: It exhibits inhibitory effects on the viral neuraminidases from two influenza viral strains, H1N1 and H9N2. Option C: It has potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. Option D: It is used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients. " A 60613 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CN(C(=O)N=C1N)C[C@@H](CO)OCP(=O)(O)O Question about this molecule: Which kind of antiviral activity does this molecule have/exhibit? Option A: It is used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients. Option B: It inhibits gene expression in HIV-1 at the transcriptional level through interference with Tat-mediated transactivation. Option C: It has potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. Option D: It exhibits inhibitory effects on the viral neuraminidases from two influenza viral strains, H1N1 and H9N2. " A 65028 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(CC)O[C@@H]1C=C(C[C@@H]([C@H]1NC(=O)C)N)C(=O)OCC Question about this molecule: Which kind of antiviral activity does this molecule have/exhibit? Option A: It exhibits inhibitory effects on the viral neuraminidases from two influenza viral strains, H1N1 and H9N2. Option B: It has potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. Option C: It inhibits gene expression in HIV-1 at the transcriptional level through interference with Tat-mediated transactivation. Option D: It inhibits the activity of the viral neuraminidase enzyme. " D 6256 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O Question about this molecule: Which kind of antiviral activity does this molecule have/exhibit? Option A: It exhibits antiviral activity against many lipid enveloped viruses including herpes simplex virus (HSV). Option B: It exhibits antiviral activity against herpes simplex virus type 1. Option C: It displays effective antiviral activity against Herpes simplex virus type 1 and 2. Option D: It exhibits antiviral activity against herpes simplex virus. " C 12620 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCCCCCCCCCCCO Question about this molecule: Which kind of antiviral activity does this molecule have/exhibit? Option A: It exhibits antiviral activity against herpes simplex virus type 1. Option B: It exhibits antiviral activity against herpes simplex virus. Option C: It displays effective antiviral activity against Herpes simplex virus type 1 and 2. Option D: It exhibits antiviral activity against many lipid enveloped viruses including herpes simplex virus (HSV). " D 440667 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@@H]([C@@H]1C(=O)C(=O)C(=O)O1)O)O Question about this molecule: Which kind of antiviral activity does this molecule have/exhibit? Option A: It has potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. Option B: It inhibits gene expression in HIV-1 at the transcriptional level through interference with Tat-mediated transactivation. Option C: It has broad spectrum activity against DNA viruses and significant antiviral activity against infections caused by a variety of viruses. Option D: It has similar biological activity as antivirals and neuroprotective effects. " D 21704 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)O)N Question about this molecule: Which kind of antiviral activity does this molecule have/exhibit? Option A: It has potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. Option B: It has broad spectrum activity against DNA viruses and significant antiviral activity against infections caused by a variety of viruses. Option C: It inhibits gene expression in HIV-1 at the transcriptional level through interference with Tat-mediated transactivation. Option D: It has similar biological activity as antivirals and neuroprotective effects. " B 2719 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind preferentially to the guanine and cytosine moieties of DNA. Option B: It can bind to heme (or FP) to form the FP-This molecule complex. Option C: It can bind to the iron atom of the enzyme cytochrome c oxidase. Option D: It can bind with high affinity to specific cytoplasmic receptors. " B 2477 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4 Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to nicotinic-cholinergic receptors at the autonomic ganglia, in the adrenal medulla, at neuromuscular junctions, and in the brain. Option B: It can bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle. Option C: It can bind to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus. Option D: It can bind to nicotinic acetylcholine receptors on dopaminergic neurons in the cortico-limbic pathways. " C 135398747 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+]1=CC=CC=C1/C=N/O Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind with high affinity to specific cytoplasmic receptors. Option B: It can cause binding to acetylcholinesterase at the anionic site. Option C: It can bind to nicotinic acetylcholine receptors of a cell. Option D: It can bind to the esteratic site of acetylcholinesterase. " D 9837243 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC[C@@H]1CC(=O)N(C1)[C@@H](CC)C(=O)N Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to SV2A with 20 times higher affinity than levetiracetam. Option B: It can bind to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus. Option C: It can bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle. Option D: It has a higher propensity to bind to muscarinic receptors than nicotinic receptors. " A 21700 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)OCC(=O)[C@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)Cl)O)C)C)OC(=O)CC Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to glucocorticoid receptors. Option B: It can bind with high affinity to specific cytoplasmic receptors. Option C: It can selectively bind to recombinant human mineralocorticoid receptors. Option D: It can cause binding to glucocorticoid receptors. " A 2733526 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC/C(=C(\\C1=CC=CC=C1)/C2=CC=C(C=C2)OCCN(C)C)/C3=CC=CC=C3 Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind and activate its receptors. Option B: It can bind to estrogen receptors (ER). Option C: It can bind with high affinity to specific cytoplasmic receptors. Option D: It can bind to 5HT2 receptors. " B 25154714 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[C@@H](C(=O)N1CCC[C@H]1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)[C@@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)OC)NC(=O)OC Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to the N-terminus of the D1 domain of NS5A. Option B: It can bind to estrogen receptors (ER). Option C: It can bind to the GnRH receptor (GnRHR). Option D: It can bind to 5HT2 receptors. " A 6013 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=CC(=O)CC[C@]34C Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to estrogen receptors (ER). Option B: It can bind to the androgen receptor. Option C: It can bind to an androgen-binding protein (ABP). Option D: It can bind and activate its receptors. " C 5975 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C-]#N Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind preferentially to the guanine and cytosine moieties of DNA. Option B: It can bind to the iron atom of the enzyme cytochrome c oxidase. Option C: It can bind with high affinity to specific cytoplasmic receptors. Option D: It can bind and activate its receptors. " B 115224 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CSC(=NC#N)N1CC2=CN=C(C=C2)Cl Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors, nicotinic acetylcholine receptors, and the serotonin receptor-ion channel complex. Option B: It can bind to nicotinic-cholinergic receptors at the autonomic ganglia, in the adrenal medulla, at neuromuscular junctions, and in the brain. Option C: It can bind to nicotinic acetylcholine receptors on dopaminergic neurons in the cortico-limbic pathways. Option D: It can bind to nicotinic acetylcholine receptors of a cell. " D 5282448 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CO[C@@H]1[C@@H]([C@H]([C@@H]([C@H](O1)COS(=O)(=O)O)O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](O2)C(=O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)COS(=O)(=O)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)C(=O)O)O[C@@H]5[C@@H]([C@H]([C@@H]([C@H](O5)COS(=O)(=O)O)O)O)NS(=O)(=O)O)O)O)OS(=O)(=O)O)NS(=O)(=O)O)O)OS(=O)(=O)O)O)NS(=O)(=O)O Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to nicotinic-cholinergic receptors at the autonomic ganglia, in the adrenal medulla, at neuromuscular junctions, and in the brain. Option B: It can bind to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus. Option C: It can bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle. Option D: It can form the high affinity binding site for the natural anti-coagulant factor, antithrombin III (ATIII). " D 54675769 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CC2=C1OC(=O)C(=C2O)NC(=O)C3=CC(=C(C=C3)O)CC=C(C)C)O[C@H]4[C@@H]([C@@H]([C@H](C(O4)(C)C)OC)OC(=O)N)O Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to DNA gyrase and block adenosine triphosphatase (ATPase) activity. Option B: It can bind to the (H+, K+)-ATPase enzyme. Option C: It can cause irreversible binding to the (H+, K+)-ATPase enzyme. Option D: It can bind to a site on the bacterial 23S ribosomal RNA of the 50S subunit. " A 5193 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(C)C1(C(=O)NC(=O)NC1=O)CC=C Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind at a distinct binding site associated with a Cl- ionopore at the GABA-A receptor, increasing the duration of time for which the Cl- ionopore is open. Option B: It can enhance the binding of GABA to GABAA receptors by acting on benzodiazepine receptors in the brain. Option C: It can bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle. Option D: It can bind to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus. " A 5280373 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC=C(C=C1)C2=COC3=CC(=CC(=C3C2=O)O)O Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind and activate its receptors. Option B: It can bind on aryl hydrocarbon receptor acting as an antagonist/agonist of the pathway. Option C: It can bind with high affinity to specific cytoplasmic receptors. Option D: It can bind to estrogen receptors (ER). " B 2809 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)C(=O)O Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind and inhibit both histamine H1 receptors and NMDA receptors. Option B: It can bind with high affinity to specific cytoplasmic receptors. Option C: It can bind nonspecifically to benzodiazepine receptors. Option D: It can bind nonspecifically to benzodiazepine receptors BNZ1 and BNZ2. " D 171548 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@H]2[C@@H]([C@@H](S1)CCCCC(=O)O)NC(=O)N2 Question about this molecule: Which kind of binding can this molecule cause? Option A: It can cause binding to the 30S ribosome. Option B: It can bind RNA in bacterial ribosomes. Option C: It can occur mainly bound to proteins or polypeptides. Option D: It can bind to a site on the bacterial 23S ribosomal RNA of the 50S subunit. " C 4506 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3 Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to nicotinic acetylcholine receptors on dopaminergic neurons in the cortico-limbic pathways. Option B: It can bind to nicotinic-cholinergic receptors at the autonomic ganglia, in the adrenal medulla, at neuromuscular junctions, and in the brain. Option C: It can enhance the binding of GABA to GABAA receptors by acting on benzodiazepine receptors in the brain. Option D: It can bind to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus. " C 9034 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC#CC(C)C1(C(=O)NC(=O)N(C1=O)C)CC=C Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle. Option B: It can bind at a distinct binding site associated with a Cl- ionopore at the GABA-A receptor, increasing the duration of time for which the Cl- ionopore is open. Option C: It can enhance the binding of GABA to GABAA receptors by acting on benzodiazepine receptors in the brain. Option D: It can bind to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus. " B 441244 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CN=C(N=C1)[N-]S(=O)(=O)C2=CC=C(C=C2)N.[Ag+] Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors, nicotinic acetylcholine receptors, and the serotonin receptor-ion channel complex. Option B: It can bind to nucleophilic amino acids, sulfhydryl, amino, imidazole, phosphate, and carboxyl groups in proteins. Option C: It can bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle. Option D: It can bind to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus. " B 4914 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCOC(=O)C1=CC=C(C=C1)N Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to nicotinic-cholinergic receptors at the autonomic ganglia, in the adrenal medulla, at neuromuscular junctions, and in the brain. Option B: It can bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle. Option C: It can bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors, nicotinic acetylcholine receptors, and the serotonin receptor-ion channel complex. Option D: It can bind to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus. " C 64715 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@H](C)C(=O)O[C@H]1CCC=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus. Option B: It can bind at a distinct binding site associated with a Cl- ionopore at the GABA-A receptor, increasing the duration of time for which the Cl- ionopore is open. Option C: It can enhance the binding of GABA to GABAA receptors by acting on benzodiazepine receptors in the brain. Option D: It can competitively inhibit HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself. " D 5757 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)O Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind with high affinity to specific cytoplasmic receptors. Option B: It can bind weakly to estrogen receptors and exhibits little estrogenic activity in estrogen-responsive tissues. Option C: It can bind to estrogen receptors (ER). Option D: It can bind and activate its receptors. " B 6446 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@]2([C@H](C[C@]4([C@H]3CC[C@]4(C)O)C)O)F Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind and activate its receptors. Option B: It can bind to the androgen receptor. Option C: It can bind to an androgen-binding protein (ABP). Option D: It can bind to estrogen receptors (ER). " B 135403657 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)(NP(=O)(O)O)O)O)O)N=C(NC2=O)N Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind and activate its receptors. Option B: It can bind with high affinity to specific cytoplasmic receptors. Option C: It can bind to estrogen receptors (ER). Option D: It can bind tightly to G-protein in the presence of Mg2+. " D 2879 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)O Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to estrogen receptors (ER). Option B: It can bind and activate its receptors. Option C: It can strongly bind to plasma protein (close to 100%). Option D: It can bind with high affinity to specific cytoplasmic receptors. " C 657298 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC1=CC(=O)NC(=S)N1 Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to tubulin at or near the vinca binding sites. Option B: It can bind to thyroid peroxidase. Option C: It can bind to microtubules. Option D: It can bind to microtubules reversibly with high affinity. " B 30699 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)OCC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)CSC3=CC=NC=C3)SC1)C(=O)O Question about this molecule: Which kind of binding can this molecule cause? Option A: It can cause binding to beta adrenergic receptors. Option B: It can cause binding to sodium channels. Option C: It can cause plasma binding. Option D: It can cause binding to T-type voltage sensitive calcium channels. " C 148124 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to spindle and cytoplasmic microtubules by binding to alpha and beta tubulin. Option B: It can bind to microtubules reversibly with high affinity. Option C: It can bind to microtubules. Option D: It can cause binding to microtubular proteins of the mitotic spindle. " B 4601 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to estrogen receptors (ER). Option B: It can bind with high affinity to specific cytoplasmic receptors. Option C: It can bind and inhibit both histamine H1 receptors and NMDA receptors. Option D: It can bind glutamate receptors, such as the NMDA receptor. " C 2727 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)Cl Question about this molecule: Which kind of binding can this molecule cause? Option A: It can cause binding to the target pancreatic β cell receptor. Option B: It can bind to the target pancreatic β cell receptor. Option C: It can selectively bind to recombinant human mineralocorticoid receptors. Option D: It can bind with high affinity to specific cytoplasmic receptors. " A 2375 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CS(=O)(=O)C1=CC=C(C=C1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind and activate its receptors. Option B: It can bind to estrogen receptors (ER). Option C: It can bind to an androgen-binding protein (ABP). Option D: It can bind to the androgen receptor. " D 33032 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(=O)O)[C@@H](C(=O)O)N Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to estrogen receptors (ER). Option B: It can bind with high affinity to specific cytoplasmic receptors. Option C: It can bind glutamate receptors, such as the NMDA receptor. Option D: It can bind and inhibit both histamine H1 receptors and NMDA receptors. " C 25419 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(P(=O)(O)O)(P(=O)(O)O)(Cl)Cl Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind metals such as mercury, lead, and cadmium tightly. Option B: It can bind with high affinity to specific cytoplasmic receptors. Option C: It can bind to SV2A with 20 times higher affinity than levetiracetam. Option D: It can bind strongly to the bone mineral, hydroxyapatite. " D 444 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind glutamate receptors, such as the NMDA receptor. Option B: It can bind to the dopamine D1 and dopamine D2 receptors. Option C: It can bind to the norepinephrine transporter (NET) and the dopamine transporter (DAT). Option D: It can bind and inhibit both histamine H1 receptors and NMDA receptors. " C 3261 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C2=NN=CN2C3=C(C=C(C=C3)Cl)C(=N1)C4=CC=CC=C4 Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind with high affinity to specific cytoplasmic receptors. Option B: It can bind nonspecifically to benzodiazepine receptors BNZ1 and BNZ2. Option C: It can bind and inhibit both histamine H1 receptors and NMDA receptors. Option D: It can bind nonspecifically to benzodiazepine receptors. " D 5862 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@@H](C(=O)O)N)S Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to SV2A with 20 times higher affinity than levetiracetam. Option B: It can bind metals such as mercury, lead, and cadmium tightly. Option C: It can bind with high affinity to specific cytoplasmic receptors. Option D: It can bind strongly to the bone mineral, hydroxyapatite. " B 5505 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to the target pancreatic β cell receptor. Option B: It can bind with high affinity to specific cytoplasmic receptors. Option C: It can selectively bind to recombinant human mineralocorticoid receptors. Option D: It can cause binding to the target pancreatic β cell receptor. " A 3226 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(OC(F)F)(F)F)(F)Cl Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane. Option B: It can bind the D subunit of ATP synthase and NADH dehydogenase. Option C: It can bind RNA in bacterial ribosomes. Option D: It can bind to a site on the bacterial 23S ribosomal RNA of the 50S subunit. " B 31703 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O Question about this molecule: Which kind of binding can this molecule cause? Option A: It can cause specific intercalation of the planar anthracycline nucleus with the DNA double helix. Option B: It can selectively bind to recombinant human mineralocorticoid receptors. Option C: It can bind with high affinity to specific cytoplasmic receptors. Option D: It can prevent receptor autophosphorylation upon ligand binding. " A 896 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind and activate its receptors. Option B: It can bind to 5HT2 receptors. Option C: It can bind with high affinity to specific cytoplasmic receptors. Option D: It can bind to estrogen receptors (ER). " A 54746 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@H]2[C@@H](CC3=CNC4=CC=CC2=C34)N(C1)CC=C Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to nicotinic-cholinergic receptors at the autonomic ganglia, in the adrenal medulla, at neuromuscular junctions, and in the brain. Option B: It has low affinity for dopamine D1, alpha1,- and alpha2- adrenergic, and 5-HT1- and 5-HT2-serotonin receptors. Option C: It can bind to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus. Option D: It can bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle. " B 213021 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=NC#N)N(C)CC1=CN=C(C=C1)Cl Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors, nicotinic acetylcholine receptors, and the serotonin receptor-ion channel complex. Option B: It can bind to nicotinic acetylcholine receptors of a cell. Option C: It can bind to nicotinic acetylcholine receptors on dopaminergic neurons in the cortico-limbic pathways. Option D: It can bind to nicotinic-cholinergic receptors at the autonomic ganglia, in the adrenal medulla, at neuromuscular junctions, and in the brain. " B 5280793 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](/C=C/[C@H](C)C(C)C)[C@H]1CC[C@@H]\\2[C@@]1(CCC/C2=C\\C=C/3\\C[C@H](CCC3=C)O)C Question about this molecule: Which kind of binding can this molecule cause? Option A: It can preferentially bind the opioid receptor. Option B: It can cause binding to the vitamin D receptor. Option C: It can bind to estrogen receptors (ER). Option D: It can bind to the vitamin D receptor. " D 4679 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C(=NC=C1)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC(F)F)OC Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to the (H+, K+)-ATPase enzyme. Option B: It can cause irreversible binding to the (H+, K+)-ATPase enzyme. Option C: It can bind RNA in bacterial ribosomes. Option D: It can bind to a site on the bacterial 23S ribosomal RNA of the 50S subunit. " A 72287 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](CN1C2=CC=CC=C2SC3=C1C=C(C=C3)OC)CN(C)C Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to 5HT2 receptors. Option B: It can bind to 5-HT 2A/2C receptor subtype. Option C: It can cause binding to human 5-HT1B and 5-HT1D receptors. Option D: It can cause binding to 5-HT2A receptors. " A 657181 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6 Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to 5HT2 receptors. Option B: It can bind to estrogen receptors (ER). Option C: It can bind to the N-terminus of the D1 domain of NS5A. Option D: It can bind to the GnRH receptor (GnRHR). " D 2724385 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5C[C@H]([C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)O)C)C)C)O)O Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind with high affinity to specific cytoplasmic receptors. Option B: It can bind to a site on the extracellular aspect of the of the Na+/K+ ATPase pump in the membranes of heart cells (myocytes). Option C: It can bind to SV2A with 20 times higher affinity than levetiracetam. Option D: It shows high affinity binding to several regions of the brain, including the medullary cough center. " B 56640146 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)C1=CC(=CC(=C1OC)C2=CC3=C(C=C2)C=C(C=C3)NS(=O)(=O)C)N4C=CC(=O)NC4=O Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to SV2A with 20 times higher affinity than levetiracetam. Option B: It can bind with high affinity to specific cytoplasmic receptors. Option C: It can bind to the non-nucleoside NS5B inhibitor binding sites. Option D: It can bind to the N-terminus of the D1 domain of NS5A. " C 54675776 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@]1([C@H]2C[C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind RNA in bacterial ribosomes. Option B: It can bind to a site on the bacterial 23S ribosomal RNA of the 50S subunit. Option C: It can bind to the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane. Option D: It can cause binding to the 30S ribosome. " C 14969 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@H]([C@@](C[C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)[C@H]([C@H](C(=O)N[C@H](C(=O)N[C@H]5C(=O)N[C@@H]7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)[C@H](NC(=O)[C@H]([C@@H](C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)[C@@H](CC(C)C)NC)O)Cl)CO)O)O)(C)N)O Question about this molecule: Which kind of binding can this molecule cause? Option A: It can cause irreversible binding to the (H+, K+)-ATPase enzyme. Option B: It can bind to the D-Ala-D-Ala. Option C: It can bind to a site on the bacterial 23S ribosomal RNA of the 50S subunit. Option D: It can bind to the (H+, K+)-ATPase enzyme. " B 62956 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(CC1)[C@@H]2C[C@H](N(C2)C(=O)CP(=O)(CCCCC3=CC=CC=C3)O)C(=O)O Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to estrogen receptors (ER). Option B: It can bind and activate its receptors. Option C: It can bind zinc with phosphinic acid group. Option D: It can bind tightly to G-protein in the presence of Mg2+. " C 28780 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCNC(=O)N1C2=CC=CC=C2N=C1NC(=O)OC Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to microtubules reversibly with high affinity. Option B: It can bind to spindle and cytoplasmic microtubules by binding to alpha and beta tubulin. Option C: It can bind to microtubules. Option D: It can cause binding to microtubular proteins of the mitotic spindle. " C 5568 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)C(F)(F)F Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind glutamate receptors, such as the NMDA receptor. Option B: It can bind to the dopamine D1 and dopamine D2 receptors. Option C: It can bind and inhibit both histamine H1 receptors and NMDA receptors. Option D: It can bind to estrogen receptors (ER). " B 4946 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O Question about this molecule: Which kind of binding can this molecule cause? Option A: It can cause binding to ATP-sensitive potassium channel receptors. Option B: It can cause binding to sodium channels. Option C: It can cause binding to beta adrenergic receptors. Option D: It can cause plasma binding. " C 241903 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O Question about this molecule: Which kind of binding can this molecule cause? Option A: It can cause binding to microtubular proteins of the mitotic spindle. Option B: It can bind to microtubules reversibly with high affinity. Option C: It can bind to microtubules. Option D: It can bind to spindle and cytoplasmic microtubules by binding to alpha and beta tubulin. " A 2474 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C Question about this molecule: Which kind of binding can this molecule cause? Option A: It can cause binding to T-type voltage sensitive calcium channels. Option B: It can cause binding to beta adrenergic receptors. Option C: It can cause plasma binding. Option D: It can cause binding to sodium channels. " D 441336 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CCl)OC(=O)C5=CC=CO5)C)O)Cl)C Question about this molecule: Which kind of binding can this molecule cause? Option A: It can cause binding to glucocorticoid receptors. Option B: It can bind with high affinity to specific cytoplasmic receptors. Option C: It can selectively bind to recombinant human mineralocorticoid receptors. Option D: It can bind to glucocorticoid receptors. " A 8378 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane. Option B: It can cause binding to the 30S ribosome. Option C: It can bind to a site on the bacterial 23S ribosomal RNA of the 50S subunit. Option D: It can bind RNA in bacterial ribosomes. " B 3393 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3F Question about this molecule: Which kind of binding can this molecule cause? Option A: It can cause binding to an allosteric site on GABA-A receptors. Option B: It can selectively bind to recombinant human mineralocorticoid receptors. Option C: It can bind with high affinity to specific cytoplasmic receptors. Option D: It can bind to glucocorticoid receptors. " A 53232 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C Question about this molecule: Which kind of binding can this molecule cause? Option A: It can cause binding to HMG-CoA reductase. Option B: It can bind to a site on the bacterial 23S ribosomal RNA of the 50S subunit. Option C: It can cause binding to the 30S ribosome. Option D: It can cause binding to b-keto-acyl-ACP synthase. " A 176870 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus. Option B: It can bind to nicotinic acetylcholine receptors on dopaminergic neurons in the cortico-limbic pathways. Option C: It can bind to the VDR and modulate the T cells gene transcription of cell differentiation and proliferation related genes. Option D: It can cause binding to the epidermal growth factor receptor (EGFR) tyrosine kinase. " D 5311071 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]\\1CC[C@@H](C/C1=C\\C=C\\2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)/C=C/[C@H](C)C(C)C)C)O Question about this molecule: Which kind of binding can this molecule cause? Option A: It can cause binding to the vitamin D receptor. Option B: It can preferentially bind the opioid receptor. Option C: It can bind to estrogen receptors (ER). Option D: It can bind to the vitamin D receptor. " A 281 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C-]#[O+] Question about this molecule: Which kind of binding can this molecule cause? Option A: It can cause binding to sodium channels. Option B: It can cause plasma binding. Option C: It can cause binding to T-type voltage sensitive calcium channels. Option D: It can cause binding to hemoglobin. " D 2131 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)CC1=CC=CC=C1Cl)CC2=CC=CC=C2Cl Question about this molecule: Which kind of binding can this molecule cause? Option A: It can cause binding to acetylcholinesterase at the anionic site. Option B: It can bind with high affinity to specific cytoplasmic receptors. Option C: It can bind to the esteratic site of acetylcholinesterase. Option D: It can bind to nicotinic acetylcholine receptors of a cell. " A 9565 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCOC1=CN=C(N=C1)NS(=O)(=O)C2=CC=CC=C2 Question about this molecule: Which kind of binding can this molecule cause? Option A: It can cause plasma binding. Option B: It can cause binding to ATP-sensitive potassium channel receptors. Option C: It can cause binding to beta adrenergic receptors. Option D: It can cause binding to sodium channels. " B 5282054 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C=C/C/C=C/CCC(=O)[C@@H]1[C@@H](O1)C(=O)N Question about this molecule: Which kind of binding can this molecule cause? Option A: It can cause binding to the 30S ribosome. Option B: It can cause binding to b-keto-acyl-ACP synthase. Option C: It can bind RNA in bacterial ribosomes. Option D: It can bind to a site on the bacterial 23S ribosomal RNA of the 50S subunit. " B 119 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(=O)O)CN Question about this molecule: Which kind of binding can this molecule cause? Option A: It can cause plasma binding. Option B: It can cause binding to specific transmembrane receptors. Option C: It can cause binding to ATP-sensitive potassium channel receptors. Option D: It can cause binding to beta adrenergic receptors. " B 3291 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC1(CC(=O)NC1=O)C Question about this molecule: Which kind of binding can this molecule cause? Option A: It can cause binding to beta adrenergic receptors. Option B: It can cause binding to T-type voltage sensitive calcium channels. Option C: It can cause binding to sodium channels. Option D: It can cause plasma binding. " B 5073 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F Question about this molecule: Which kind of binding can this molecule cause? Option A: It can cause binding to human 5-HT1B and 5-HT1D receptors. Option B: It can bind to 5-HT 2A/2C receptor subtype. Option C: It can bind to 5HT2 receptors. Option D: It can cause binding to 5-HT2A receptors. " D 5284570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3C(=O)CC4 Question about this molecule: Which kind of binding can this molecule cause? Option A: It can cause binding to sodium channels. Option B: It can cause plasma binding. Option C: It can cause binding to T-type voltage sensitive calcium channels. Option D: It can cause binding to kappa-receptors. " D 4114 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2 Question about this molecule: Which kind of binding can this molecule cause? Option A: It can bind with high affinity to specific cytoplasmic receptors. Option B: It can bind to estrogen receptors (ER). Option C: It can bind preferentially to the guanine and cytosine moieties of DNA. Option D: It can bind and activate its receptors. " C 63107 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C2=C(C=C(C=C2Cl)Cl)Cl)Cl Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: There is some concern regarding its potential for bioaccumulation. Option B: It bioaccumulates and causes harmful health effects. Option C: It was found to bioaccumulate and cause harmful health effects. Option D: It is banned in the 1970's because it bioaccumulates and causes harmful health effects. " C 1549008 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)C#C/C=C/CN(C)CC1=CC=CC2=CC=CC=C21 Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: It accumulates in the tissues, especially in nervous structures. Option B: There is a slight concern regarding its ability to bioaccumulate. Option C: There is some concern regarding its potential for bioaccumulation. Option D: It tends to accumulate in skin, nails, and fatty tissues. " D 36647 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1Cl)C2=C(C=C(C=C2Cl)Cl)Cl)Cl)Cl Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: It bioaccumulates and causes harmful health effects. Option B: It was found to bioaccumulate and cause harmful health effects. Option C: There is some concern regarding its potential for bioaccumulation. Option D: It is banned in the 1970's because it bioaccumulates and causes harmful health effects. " B 171548 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@H]2[C@@H]([C@@H](S1)CCCCC(=O)O)NC(=O)N2 Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: It is banned in the 1970's because it bioaccumulates and causes harmful health effects. Option B: Human cells accumulate it by using both the sodium-dependent multivitamin transporter and monocarboxylate transporter 1. Option C: There is some concern regarding its potential for bioaccumulation. Option D: It tends to accumulate in skin, nails, and fatty tissues. " B 967 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(NC(=O)NC1=O)C(=O)O Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: It accumulates to high concentrations in plasma. Option B: It accumulates in white blood cells. Option C: It tends to bioaccumulate. Option D: It accumulates in the cytoplasm. " A 36982 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)C2=CC=C(C=C2)Cl)Cl Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: It was found to bioaccumulate and cause harmful health effects. Option B: It bioaccumulates and causes harmful health effects. Option C: It is banned in the 1970's because it bioaccumulates and causes harmful health effects. Option D: There is some concern regarding its potential for bioaccumulation. " A 16318 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=C(C(=C(C(=C1Cl)Cl)Cl)Cl)Cl)C2=C(C(=C(C(=C2Cl)Cl)Cl)Cl)Cl Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: It bioaccumulates and causes harmful health effects. Option B: There is some concern regarding its potential for bioaccumulation. Option C: It is banned in the 1970's because it bioaccumulates and causes harmful health effects. Option D: It was found to bioaccumulate and cause harmful health effects. " D 3652 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: It accumulates in white blood cells. Option B: It tends to bioaccumulate. Option C: It accumulates to high concentrations in plasma. Option D: It accumulates in the cytoplasm. " A 91756 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC1=NC(=NC(=N1)NC(=O)NS(=O)(=O)C2=CC=CC=C2C(=O)OC)NC Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: There is a slight concern regarding its ability to bioaccumulate. Option B: It is not expected to bioaccumulate. Option C: It tends to bioaccumulate. Option D: It may bio-accumulate. " D 36187 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1C2=CC(=C(C=C2)Cl)Cl)Cl)Cl Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: It is banned in the 1970's because it bioaccumulates and causes harmful health effects. Option B: It bioaccumulates and causes harmful health effects. Option C: There is some concern regarding its potential for bioaccumulation. Option D: It was found to bioaccumulate and cause harmful health effects. " D 36402 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2=C(C(=CC(=C2Cl)Cl)Cl)Cl Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: It is banned in the 1970's because it bioaccumulates and causes harmful health effects. Option B: It was found to bioaccumulate and cause harmful health effects. Option C: It bioaccumulates and causes harmful health effects. Option D: There is some concern regarding its potential for bioaccumulation. " B 1060 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C(=O)O Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: It accumulates in the tissues, especially in nervous structures. Option B: There is a slight concern regarding its ability to bioaccumulate. Option C: It tends to accumulate in skin, nails, and fatty tissues. Option D: There is some concern regarding its potential for bioaccumulation. " A 6262 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C[C@@H](C(=O)O)N)CN Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: It accumulates in white blood cells. Option B: It accumulates in the cytoplasm. Option C: It tends to bioaccumulate. Option D: It accumulates to high concentrations in plasma. " B 63090 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1C2=CC(=C(C(=C2)Cl)Cl)Cl)Cl)Cl Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: It was found to bioaccumulate and cause harmful health effects. Option B: There is some concern regarding its potential for bioaccumulation. Option C: It bioaccumulates and causes harmful health effects. Option D: It is banned in the 1970's because it bioaccumulates and causes harmful health effects. " A 41540 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2=C(C=CC(=C2Cl)Cl)Cl Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: It is banned in the 1970's because it bioaccumulates and causes harmful health effects. Option B: There is some concern regarding its potential for bioaccumulation. Option C: It was found to bioaccumulate and cause harmful health effects. Option D: It bioaccumulates and causes harmful health effects. " C 38033 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC(=C1)Cl)C2=C(C=CC(=C2)Cl)Cl Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: There is some concern regarding its potential for bioaccumulation. Option B: It bioaccumulates and causes harmful health effects. Option C: It is banned in the 1970's because it bioaccumulates and causes harmful health effects. Option D: It was found to bioaccumulate and cause harmful health effects. " D 9555 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(C(C(C(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)O Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: It is not expected to bioaccumulate. Option B: It tends to bioaccumulate. Option C: It is persistent and bioaccumulative. Option D: It may bio-accumulate. " C 41541 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2=C(C(=C(C=C2)Cl)Cl)Cl Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: It was found to bioaccumulate and cause harmful health effects. Option B: There is some concern regarding its potential for bioaccumulation. Option C: It is banned in the 1970's because it bioaccumulates and causes harmful health effects. Option D: It bioaccumulates and causes harmful health effects. " C 37249 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1C2=C(C(=CC(=C2)Cl)Cl)Cl)Cl)Cl)Cl Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: There is some concern regarding its potential for bioaccumulation. Option B: It was found to bioaccumulate and cause harmful health effects. Option C: It bioaccumulates and causes harmful health effects. Option D: It is banned in the 1970's because it bioaccumulates and causes harmful health effects. " C 51041 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)C2=CC(=C(C=C2Cl)Cl)Cl)Cl Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: There is some concern regarding its potential for bioaccumulation. Option B: It was found to bioaccumulate and cause harmful health effects. Option C: It is banned in the 1970's because it bioaccumulates and causes harmful health effects. Option D: It bioaccumulates and causes harmful health effects. " D 213032 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C(=O)N(C(=O)O1)NC2=CC=CC=C2)C3=CC=C(C=C3)OC4=CC=CC=C4 Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: It was found to bioaccumulate and cause harmful health effects. Option B: It bioaccumulates and causes harmful health effects. Option C: There is some concern regarding its potential for bioaccumulation. Option D: There is a slight concern regarding its ability to bioaccumulate. " D 36981 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2=CC(=CC(=C2)Cl)Cl Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: It is banned in the 1970's because it bioaccumulates and causes harmful health effects. Option B: It bioaccumulates and causes harmful health effects. Option C: It was found to bioaccumulate and cause harmful health effects. Option D: There is some concern regarding its potential for bioaccumulation. " B 77222 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(C(C(C(C(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)O Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: It is not expected to bioaccumulate. Option B: It tends to bioaccumulate. Option C: It may bio-accumulate. Option D: It is persistent and bioaccumulative. " D 16308 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C2=CC=C(C=C2)Cl)Cl Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: There is some concern regarding its potential for bioaccumulation. Option B: It bioaccumulates and causes harmful health effects. Option C: It is banned in the 1970's because it bioaccumulates and causes harmful health effects. Option D: It was found to bioaccumulate and cause harmful health effects. " B 36980 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2=C(C=CC(=C2)Cl)Cl Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: It bioaccumulates and causes harmful health effects. Option B: There is some concern regarding its potential for bioaccumulation. Option C: It was found to bioaccumulate and cause harmful health effects. Option D: It is banned in the 1970's because it bioaccumulates and causes harmful health effects. " A 36304 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C2=C(C(=C(C=C2)Cl)Cl)Cl)Cl Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: It is banned in the 1970's because it bioaccumulates and causes harmful health effects. Option B: There is some concern regarding its potential for bioaccumulation. Option C: It was found to bioaccumulate and cause harmful health effects. Option D: It bioaccumulates and causes harmful health effects. " D 37248 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1Cl)C2=C(C=CC(=C2)Cl)Cl)Cl Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: It is banned in the 1970's because it bioaccumulates and causes harmful health effects. Option B: It was found to bioaccumulate and cause harmful health effects. Option C: It bioaccumulates and causes harmful health effects. Option D: There is some concern regarding its potential for bioaccumulation. " C 36342 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2=C(C=CC=C2Cl)Cl Question about this molecule: What is the right information about this molecule's bioaccumulation? Option A: It was found to bioaccumulate and cause harmful health effects. Option B: It is banned in the 1970's because it bioaccumulates and causes harmful health effects. Option C: There is some concern regarding its potential for bioaccumulation. Option D: It bioaccumulates and causes harmful health effects. " D 8029 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=COC=C1 Question about this molecule: What is the right information about this molecule's boiling point? Option A: It has a boiling point close to room temperature. Option B: It has a low boiling point. Option C: Its boiling point is 56.8 °C. Option D: It boils at a higher temperature than water. " A 5921 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)N=O Question about this molecule: What is the right information about this molecule's boiling point? Option A: Its boiling point is 240-243 °C (464-469 °F). Option B: Its boiling point is slightly above room temperature at 26 °C (79 °F). Option C: Its boiling point is 175-177 °C. Option D: Its boiling point is 56.8 °C. " C 5975 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C-]#N Question about this molecule: What is the right information about this molecule's boiling point? Option A: Its boiling point is slightly above room temperature at 26 °C (78.8 °F). Option B: Its boiling point is 175-177 °C. Option C: Its boiling point is 240-243 °C (464-469 °F). Option D: Its boiling point is slightly above room temperature at 26 °C (79 °F). " A 7002 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC2=CC=CC=C12 Question about this molecule: What is the right information about this molecule's boiling point? Option A: Its boiling point is slightly above room temperature at 26 °C (78.8 °F). Option B: Its boiling point is 175-177 °C. Option C: Its boiling point is 240-243 °C (464-469 °F). Option D: Its boiling point is slightly above room temperature at 26 °C (79 °F). " C 6574 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)Cl)Cl Question about this molecule: What is the right information about this molecule's boiling point? Option A: Its boiling point is 56.8 °C. Option B: It boils at a higher temperature than water. Option C: It has a boiling point close to room temperature. Option D: It has a low boiling point. " B 3226 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(OC(F)F)(F)F)(F)Cl Question about this molecule: What is the right information about this molecule's boiling point? Option A: Its boiling point is 175-177 °C. Option B: Its boiling point is 56.8 °C. Option C: Its boiling point is slightly above room temperature at 26 °C (79 °F). Option D: Its boiling point is 240-243 °C (464-469 °F). " B 3283 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOCC Question about this molecule: What is the right information about this molecule's boiling point? Option A: It has a low boiling point. Option B: Its boiling point is 56.8 °C. Option C: It boils at a higher temperature than water. Option D: It has a boiling point close to room temperature. " A 768 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C#N Question about this molecule: What is the right information about this molecule's boiling point? Option A: Its boiling point is slightly above room temperature at 26 °C (78.8 °F). Option B: Its boiling point is slightly above room temperature at 26 °C (79 °F). Option C: Its boiling point is 175-177 °C. Option D: Its boiling point is 240-243 °C (464-469 °F). " B 12228 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN=C=O Question about this molecule: What is the right information about this molecule's boiling point? Option A: It boils at a higher temperature than water. Option B: It is a low-boiling liquid. Option C: It has a boiling point close to room temperature. Option D: It has a low boiling point. " B 8029 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=COC=C1 Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is carcinogenic to humans by inhalation. Option B: It is probably carcinogenic to humans. Option C: It may be carcinogenic. Option D: It is possibly carcinogenic to humans. " C 3035 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C(=C(Cl)Cl)C2=CC=C(C=C2)Cl)Cl Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is classified as a Group C, possible human carcinogen. Option B: It is classified as a Group B2, probable human carcinogen. Option C: It is classified as a Group 2B, possible human carcinogen. Option D: It is classified as a probable human carcinogen. " D 12699 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C(=O)N)N=O Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is classified as a Group B2, probable human carcinogen. Option B: It is classified as a Group C, possible human carcinogen. Option C: It is classified as a probable human carcinogen. Option D: It is classified as a Group 2B, possible human carcinogen. " C 2478 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CS(=O)(=O)OCCCCOS(=O)(=O)C Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is listed as a known carcinogen. Option B: It is a possible human carcinogen. Option C: It is a potential carcinogen. Option D: It is classified as a probable human carcinogen. " A 6569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)C Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is not classified for carcinogenicity. Option B: It is not classifiable as to human carcinogenicity. Option C: It is classified as a Group C, possible human carcinogen. Option D: It is classified as a Group 2B, possible human carcinogen. " B 6278 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(Cl)(Cl)Cl Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is not classifiable as to human carcinogenicity. Option B: It is not classified for carcinogenicity. Option C: It is classified as a Group C, possible human carcinogen. Option D: It is classified as a Group 2B, possible human carcinogen. " A 11443 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)N=C=O)N=C=O Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is classified as a Group 2B, possible human carcinogen. Option B: It is classified as a Group C, possible human carcinogen. Option C: It is classified as a probable human carcinogen. Option D: It is classified as a Group B2, probable human carcinogen. " C 7845 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC=C Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is possibly carcinogenic to humans. Option B: It is carcinogenic to humans by inhalation. Option C: It may be carcinogenic. Option D: It is probably carcinogenic to humans. " B 8058 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is not classified for carcinogenicity. Option B: It is not classifiable as to human carcinogenicity. Option C: It is classified as a Group 2B, possible human carcinogen. Option D: It is classified as a Group C, possible human carcinogen. " B 7367 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(Cl)(Cl)Cl Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is classified as a Group C, possible human carcinogen. Option B: It is classified as a Group 2B, possible human carcinogen. Option C: It is classified as a probable human carcinogen. Option D: It is classified as a Group B2, probable human carcinogen. " C 5975 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C-]#N Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is not classified for carcinogenicity. Option B: It is not classifiable as to human carcinogenicity. Option C: It is classified as a Group 2B, possible human carcinogen. Option D: It is classified as a Group C, possible human carcinogen. " B 991 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OC1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is classified as a Group C, possible human carcinogen. Option B: It is classified as a Group 2B, possible human carcinogen. Option C: It is classified as a probable human carcinogen. Option D: It is classified as a Group B2, probable human carcinogen. " C 6212 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)(Cl)Cl Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is possibly carcinogenic to humans. Option B: It is probably carcinogenic to humans. Option C: It is carcinogenic to humans by inhalation. Option D: It is carcinogenic in animals after oral exposure. " D 7102 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)N Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is classified as a Group 2B, possible human carcinogen. Option B: It is classified as a Group B2, probable human carcinogen. Option C: It is classified as a Group 1 carcinogen, carcinogenic to humans. Option D: It is classified as a Group C, possible human carcinogen. " C 5976 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)N Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It may be carcinogenic. Option B: It is probably carcinogenic to humans. Option C: It is carcinogenic to humans by inhalation. Option D: It is possibly carcinogenic to humans. " D 3039 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=O)(OC)OC=C(Cl)Cl Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is a possible human carcinogen. Option B: It is classified as a probable human carcinogen. Option C: Known human carcinogen. Option D: It is a potential carcinogen. " A 7000 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC=CC=C1N Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is a possible human carcinogen. Option B: It is classified as a probable human carcinogen. Option C: Known human carcinogen. Option D: It is a potential carcinogen. " A 31373 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=C(Cl)Cl)(Cl)Cl Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is probably carcinogenic to humans. Option B: It is possibly carcinogenic to humans. Option C: It is carcinogenic to humans by inhalation. Option D: It may be carcinogenic. " A 29393 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN(CCC)C1=C(C=C(C=C1[N+](=O)[O-])S(=O)(=O)N)[N+](=O)[O-] Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is a possible human carcinogen. Option B: It is classified as a probable human carcinogen. Option C: Known human carcinogen. Option D: It is a potential carcinogen. " D 6574 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)Cl)Cl Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is a possible human carcinogen. Option B: It is a potential carcinogen. Option C: It is classified as a probable human carcinogen. Option D: Known human carcinogen. " A 241 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=CC=C1 Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is a known human carcinogen for all routes of exposure. Option B: It is a probable human carcinogen based on animal studies. Option C: It is classified as a probable human carcinogen. Option D: It is classified as a Group C, possible human carcinogen. " A 6544 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=O)CC(C1)(C)C Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is a possible human carcinogen. Option B: Known human carcinogen. Option C: It is a potential carcinogen. Option D: It is classified as a probable human carcinogen. " A 8607 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=O)N(C2=O)SC(Cl)(Cl)Cl Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is carcinogenic in animals after oral exposure. Option B: It is probably carcinogenic to humans. Option C: It is carcinogenic in mice (but not rats). Option D: It is carcinogenic to humans by inhalation. " C 7047 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC=N2 Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is classified as a Group 2B, possible human carcinogen. Option B: It is classified as a Group C, possible human carcinogen. Option C: It is provisionally classified as a Group C, possible human carcinogen. Option D: It is classified as a Group B2, probable human carcinogen. " C 5569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN(CCC)C1=C(C=C(C=C1[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-] Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is classified as a Group C, possible human carcinogen. Option B: It is classified as a Group 2B, possible human carcinogen. Option C: It is classified as a Group B1, probable human carcinogen. Option D: It is classified as a Group B2, probable human carcinogen. " A 2708 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is classified as a probable human carcinogen. Option B: It is listed as a known carcinogen. Option C: It is a potential carcinogen. Option D: It is a possible human carcinogen. " B 7570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CC2=CC=C(C=C2)N=C=O)N=C=O Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is not classified for carcinogenicity. Option B: It is not classifiable as to human carcinogenicity. Option C: It is classified as a Group 2B, possible human carcinogen. Option D: It is classified as a Group C, possible human carcinogen. " B 712 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=O Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is classified as a Group B2, probable human carcinogen. Option B: It is classified as a Group 2B, possible human carcinogen. Option C: It is classified as a Group B1, probable human carcinogen. Option D: It is classified as a Group C, possible human carcinogen. " C 7577 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CC2=CC=C(C=C2)N)N Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is not classifiable as to human carcinogenicity. Option B: It is classified as a Group 2B, possible human carcinogen. Option C: It is not classified for carcinogenicity. Option D: It is classified as a Group C, possible human carcinogen. " C 24404 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: P Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is not classified for carcinogenicity. Option B: It is not classifiable as to human carcinogenicity. Option C: It is classified as a Group 2B, possible human carcinogen. Option D: It is classified as a Group C, possible human carcinogen. " B 104730 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Co] Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is not classifiable as to human carcinogenicity. Option B: It is not classified for carcinogenicity. Option C: It is classified as a Group C, possible human carcinogen. Option D: It is classified as a Group 2B, possible human carcinogen. " B 5144 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCC1=CC2=C(C=C1)OCO2 Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: Known human carcinogen. Option B: It is a weak hepatocarcinogen. Option C: It is a possible human carcinogen. Option D: It is classified as a probable human carcinogen. " B 177 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC=O Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is a known human carcinogen for all routes of exposure. Option B: It is classified as a probable human carcinogen. Option C: It is a probable human carcinogen based on animal studies. Option D: It is classified as a Group C, possible human carcinogen. " C 6129 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC(=O)OC1=CC=CC2=CC=CC=C21 Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is classified as a Group 2B, possible human carcinogen. Option B: It is not classifiable as to human carcinogenicity. Option C: It is not classified for carcinogenicity. Option D: It is classified as a Group C, possible human carcinogen. " B 7095 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2=CC=CC=C2 Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is classified as a Group C, possible human carcinogen. Option B: It is not classified for carcinogenicity. Option C: It is classified as a Group 2B, possible human carcinogen. Option D: It is not classifiable as to human carcinogenicity. " D 6046 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1COCCN1N=O Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is classified as a Group B2, probable human carcinogen. Option B: It is classified as a Group 2B, possible human carcinogen. Option C: It is classified as a Group B1, probable human carcinogen. Option D: It is classified as a Group C, possible human carcinogen. " B 6811 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=O)OC2=O Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is not classifiable as to human carcinogenicity. Option B: It is classified as a Group 2B, possible human carcinogen. Option C: It is not classified for carcinogenicity. Option D: It is classified as a Group C, possible human carcinogen. " C 7964 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)Cl Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is not classifiable as to human carcinogenicity. Option B: It is not classified for carcinogenicity. Option C: It is classified as a Group 2B, possible human carcinogen. Option D: It is classified as a Group C, possible human carcinogen. " A 289 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)O)O Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is classified as a Group 2B, possible human carcinogen. Option B: It is classified as a Group B2, probable human carcinogen. Option C: It is classified as a Group C, possible human carcinogen. Option D: It is classified as a Group B1, probable human carcinogen. " A 996 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)O Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is not classifiable as to human carcinogenicity. Option B: It is classified as a Group 2B, possible human carcinogen. Option C: It is not classified for carcinogenicity. Option D: It is classified as a Group C, possible human carcinogen. " A 6497 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COS(=O)(=O)OC Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is a potential carcinogen. Option B: It is a possible human carcinogen. Option C: It is classified as a probable human carcinogen. Option D: Known human carcinogen. " B 6591 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)Cl)(Cl)Cl Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is classified as a probable human carcinogen. Option B: It is a potential carcinogen. Option C: It is a possible human carcinogen. Option D: Known human carcinogen. " C 992 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=C(C(=C(C(=C1Cl)Cl)Cl)Cl)Cl)O Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is a potential carcinogen. Option B: Known human carcinogen. Option C: It is classified as a probable human carcinogen. Option D: It is a possible human carcinogen. " D 935 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Ni] Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: Known human carcinogen. Option B: Human carcinogen Option C: It is classified as a probable human carcinogen. Option D: It is a possible human carcinogen. " B 44073 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1C(F)(F)F)Cl)OC2=CC(=C(C=C2)[N+](=O)[O-])C(=O)O Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is a potential carcinogen. Option B: It is a possible human carcinogen. Option C: It is classified as a probable human carcinogen. Option D: Known human carcinogen. " B 6564 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CCl)Cl Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is classified as a probable human carcinogen. Option B: It is a possible human carcinogen. Option C: Known human carcinogen. Option D: It is a potential carcinogen. " B 6214 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)(Cl)Cl)(Cl)(Cl)Cl Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is a possible human carcinogen. Option B: It is a potential carcinogen. Option C: Known human carcinogen. Option D: It is classified as a probable human carcinogen. " A 6337 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCl Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is classified as a Group 1 carcinogen, carcinogenic to humans. Option B: It is classified as a Group 2B, possible human carcinogen. Option C: Carcinogenic in female mice, may be carcinogenic in rats Option D: It is classified as a Group C, possible human carcinogen. " C 7855 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC#N Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is a potential carcinogen. Option B: Known human carcinogen. Option C: It is classified as a probable human carcinogen. Option D: It is a possible human carcinogen. " D 6342 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC#N Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is not classified for carcinogenicity. Option B: It is not classifiable as to human carcinogenicity. Option C: It is classified as a Group C, possible human carcinogen. Option D: It is classified as a Group 2B, possible human carcinogen. " B 6327 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCl Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is classified as a Group C, possible human carcinogen. Option B: It is not classified for carcinogenicity. Option C: It is not classifiable as to human carcinogenicity. Option D: It is classified as a Group 2B, possible human carcinogen. " C 7416 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is not classified for carcinogenicity. Option B: It is classified as a Group C, possible human carcinogen. Option C: It is classified as a Group 2B, possible human carcinogen. Option D: It is not classifiable as to human carcinogenicity. " D 12228 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN=C=O Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is classified as a Group C, possible human carcinogen. Option B: It is not classifiable as to human carcinogenicity. Option C: It is classified as a Group 2B, possible human carcinogen. Option D: It is not classified for carcinogenicity. " B 5284429 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O.O.O.O.O.O.[O-]S(=O)(=O)[O-].[Ni+2] Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: Toxic and carcinogenic. Option B: It is probably carcinogenic to humans. Option C: It is possibly carcinogenic to humans. Option D: It may be carcinogenic. " A 6115 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)N Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is classified as a probable human carcinogen. Option B: It is a possible human carcinogen. Option C: Known human carcinogen. Option D: It is a potential carcinogen. " B 7111 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C2=CC=C(C=C2)N)N Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: Known human carcinogen. Option B: It is a potential carcinogen. Option C: It is classified as a probable human carcinogen. Option D: It is a possible human carcinogen. " A 7835 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C(O1)CCl Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: Known human carcinogen. Option B: It is a possible human carcinogen. Option C: It is a potential carcinogen. Option D: It is classified as a probable human carcinogen. " B 398 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[N+](=O)[O-] Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is a possible human carcinogen. Option B: Known human carcinogen. Option C: It is a potential carcinogen. Option D: It is classified as a probable human carcinogen. " A 931 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C=CC=CC2=C1 Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is a potential carcinogen. Option B: Known human carcinogen. Option C: It is classified as a probable human carcinogen. Option D: It is a possible human carcinogen. " D 6323 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CBr Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is not classifiable as to human carcinogenicity. Option B: It is classified as a Group 2B, possible human carcinogen. Option C: It is not classified for carcinogenicity. Option D: It is classified as a Group C, possible human carcinogen. " A 568 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C3=CC=CC=C3O2 Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is not classifiable as to human carcinogenicity. Option B: It is classified as a Group 2B, possible human carcinogen. Option C: It is classified as a Group C, possible human carcinogen. Option D: It is not classified for carcinogenicity. " A 3026 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit? Option A: It is classified as a Group 2B, possible human carcinogen. Option B: It is classified as a Group C, possible human carcinogen. Option C: It is not classified for carcinogenicity. Option D: It is not classifiable as to human carcinogenicity. " D 6051 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)N=NC2=CC=C(C=C2)N Question about this molecule: What is the color of this molecule? Option A: Blackish-brown. Option B: Colorless, yellowish (commercial samples). Option C: Colorless, red-brown tint (due to impurities). Option D: Brownish-yellow with bluish coating, or orange. " D 8076 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOCCO Question about this molecule: What is the color of this molecule? Option A: Green. Option B: Colorless. Option C: Dark orange. Option D: Amber to black. " B 5447130 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(OC(=C1)[N+](=O)[O-])/C=N/NC(=O)N Question about this molecule: What is the color of this molecule? Option A: Amber to black. Option B: Colorless, yellowish (commercial samples). Option C: Dark orange. Option D: Blackish-brown. " C 5281744 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C=C\\1/CC(=C)[C@@](C(=O)OCC2=CCN3[C@H]2[C@@H](CC3)OC1=O)(CO)O Question about this molecule: What is the color of this molecule? Option A: Colorless, yellowish (commercial samples). Option B: Blackish-brown. Option C: Dark orange. Option D: Amber to black. " B 445639 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCC/C=C\\CCCCCCCC(=O)O Question about this molecule: What is the color of this molecule? Option A: Dark orange. Option B: Amber to black. Option C: Blackish-brown. Option D: Colorless, yellowish (commercial samples). " D 7239 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)Cl)Cl Question about this molecule: What is the color of this molecule? Option A: Amber to black. Option B: Green. Option C: Colorless. Option D: Dark orange. " C 31276 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CCOC(=O)C Question about this molecule: What is the color of this molecule? Option A: Dark orange. Option B: Amber to black. Option C: Green. Option D: Colorless. " D 7921 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1CCC(=O)O1 Question about this molecule: What is the color of this molecule? Option A: Dark orange. Option B: Colorless. Option C: Green. Option D: Amber to black. " B 1030 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CO)O Question about this molecule: What is the color of this molecule? Option A: Green. Option B: Amber to black. Option C: Dark orange. Option D: Colorless. " D 935 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Ni] Question about this molecule: What is the color of this molecule? Option A: Amber to black. Option B: Colorless. Option C: Green. Option D: Dark orange. " C 6327 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCl Question about this molecule: What is the color of this molecule? Option A: Amber to black. Option B: Dark orange. Option C: Colorless. Option D: Green. " C 460 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC=CC=C1O Question about this molecule: What is the color of this molecule? Option A: Green. Option B: Colorless. Option C: Dark orange. Option D: Amber to black. " D 6115 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)N Question about this molecule: What is the color of this molecule? Option A: Colorless, yellowish (commercial samples). Option B: Blackish-brown. Option C: Brownish-yellow with bluish coating, or orange. Option D: Colorless, red-brown tint (due to impurities). " D 5280343 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O Question about this molecule: What is the right information about this molecule's conversion? Option A: It converts to anhydrous form at 203-207 °F. Option B: It is converted into its active form benazeprilat by cleavage of its ester group by the liver. Option C: It must first cross the inner mitochondrial membrane into the mitochondrial matrix where it is carbamylated by this moleculetranscarbamylase in order to be converted to citrulline. Option D: The levo-isomer is rapidly converted to the biologically available methyl-tetrahydrofolate form, while the dextro form is slowly excreted by the kidneys. " A 1054 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NC=C(C(=C1O)CO)CO Question about this molecule: What is the right information about this molecule's conversion? Option A: Any this molecule used on the plant is converted very quickly to ethylene. Option B: It is converted to UMP by UMP synthase. Option C: Some of it is converted in peripheral tissues to testosterone and estrogens. Option D: It is converted to pyridoxal 5-phosphate in the body. " D 5790 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)F)CO)O Question about this molecule: What is the right information about this molecule's conversion? Option A: It must first cross the inner mitochondrial membrane into the mitochondrial matrix where it is carbamylated by this moleculetranscarbamylase in order to be converted to citrulline. Option B: It is converted to floxuridine monophosphate when administered by slow, continuous, intra-arterial infusion. Option C: It can be converted to active vitamin K2, menaquinone, after alkylation in vivo. Option D: It is converted into its active form benazeprilat by cleavage of its ester group by the liver. " B 4055 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=O)C2=CC=CC=C2C1=O Question about this molecule: What is the right information about this molecule's conversion? Option A: It can be converted to active vitamin K2, menaquinone, after alkylation in vivo. Option B: It must first cross the inner mitochondrial membrane into the mitochondrial matrix where it is carbamylated by this moleculetranscarbamylase in order to be converted to citrulline. Option C: It is converted into its active form benazeprilat by cleavage of its ester group by the liver. Option D: The levo-isomer is rapidly converted to the biologically available methyl-tetrahydrofolate form, while the dextro form is slowly excreted by the kidneys. " A 135403648 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O Question about this molecule: What is the right information about this molecule's conversion? Option A: It is converted into its active form benazeprilat by cleavage of its ester group by the liver. Option B: It must first cross the inner mitochondrial membrane into the mitochondrial matrix where it is carbamylated by this moleculetranscarbamylase in order to be converted to citrulline. Option C: It is converted into acetaldehyde by alcohol dehydrogenase and then into acetic acid by acetaldehyde dehydrogenase. Option D: The levo-isomer is rapidly converted to the biologically available methyl-tetrahydrofolate form, while the dextro form is slowly excreted by the kidneys. " D 967 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(NC(=O)NC1=O)C(=O)O Question about this molecule: What is the right information about this molecule's conversion? Option A: Any this molecule used on the plant is converted very quickly to ethylene. Option B: It is converted to pyridoxal 5-phosphate in the body. Option C: Some of it is converted in peripheral tissues to testosterone and estrogens. Option D: It is converted to UMP by UMP synthase. " D 5362124 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@H]2CCC3=CC=CC=C3N(C2=O)CC(=O)O Question about this molecule: What is the right information about this molecule's conversion? Option A: It is converted into acetaldehyde by alcohol dehydrogenase and then into acetic acid by acetaldehyde dehydrogenase. Option B: It must first cross the inner mitochondrial membrane into the mitochondrial matrix where it is carbamylated by this moleculetranscarbamylase in order to be converted to citrulline. Option C: The levo-isomer is rapidly converted to the biologically available methyl-tetrahydrofolate form, while the dextro form is slowly excreted by the kidneys. Option D: It is converted into its active form benazeprilat by cleavage of its ester group by the liver. " D 439391 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(=O)O)[C@H](C(=O)O)O Question about this molecule: What is the right information about this molecule's conversion? Option A: The levo-isomer is rapidly converted to the biologically available methyl-tetrahydrofolate form, while the dextro form is slowly excreted by the kidneys. Option B: It must first cross the inner mitochondrial membrane into the mitochondrial matrix where it is carbamylated by this moleculetranscarbamylase in order to be converted to citrulline. Option C: It can be converted to α-ketoglutaric acid through the action of a 2-hydroxyglutarate dehydrogenase. Option D: It is converted into acetaldehyde by alcohol dehydrogenase and then into acetic acid by acetaldehyde dehydrogenase. " C 6262 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C[C@@H](C(=O)O)N)CN Question about this molecule: What is the right information about this molecule's conversion? Option A: It is converted into its active form benazeprilat by cleavage of its ester group by the liver. Option B: The levo-isomer is rapidly converted to the biologically available methyl-tetrahydrofolate form, while the dextro form is slowly excreted by the kidneys. Option C: It must first cross the inner mitochondrial membrane into the mitochondrial matrix where it is carbamylated by this moleculetranscarbamylase in order to be converted to citrulline. Option D: It is converted into acetaldehyde by alcohol dehydrogenase and then into acetic acid by acetaldehyde dehydrogenase. " C 702 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCO Question about this molecule: What is the right information about this molecule's conversion? Option A: The levo-isomer is rapidly converted to the biologically available methyl-tetrahydrofolate form, while the dextro form is slowly excreted by the kidneys. Option B: It must first cross the inner mitochondrial membrane into the mitochondrial matrix where it is carbamylated by this moleculetranscarbamylase in order to be converted to citrulline. Option C: It is converted into acetaldehyde by alcohol dehydrogenase and then into acetic acid by acetaldehyde dehydrogenase. Option D: It is converted into its active form benazeprilat by cleavage of its ester group by the liver. " C 135398559 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@@H](N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O Question about this molecule: What is the right information about this molecule's conversion? Option A: It is converted into acetaldehyde by alcohol dehydrogenase and then into acetic acid by acetaldehyde dehydrogenase. Option B: It must first cross the inner mitochondrial membrane into the mitochondrial matrix where it is carbamylated by this moleculetranscarbamylase in order to be converted to citrulline. Option C: It is converted into its active form benazeprilat by cleavage of its ester group by the liver. Option D: The levo-isomer is rapidly converted to the biologically available methyl-tetrahydrofolate form, while the dextro form is slowly excreted by the kidneys. " D 6128 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CCC4=O)C Question about this molecule: What is the right information about this molecule's conversion? Option A: It is converted into its active form benazeprilat by cleavage of its ester group by the liver. Option B: It converts to anhydrous form at 203-207 °F. Option C: It can be converted to active vitamin K2, menaquinone, after alkylation in vivo. Option D: Some of it is converted in peripheral tissues to testosterone and estrogens. " D 27982 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCl)P(=O)(O)O Question about this molecule: What is the right information about this molecule's conversion? Option A: The levo-isomer is rapidly converted to the biologically available methyl-tetrahydrofolate form, while the dextro form is slowly excreted by the kidneys. Option B: It converts to anhydrous form at 203-207 °F. Option C: Any this molecule used on the plant is converted very quickly to ethylene. Option D: It is converted into its active form benazeprilat by cleavage of its ester group by the liver. " C 439939 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(=O)O)[C@@H](C(=O)O)O Question about this molecule: What is the right information about this molecule's conversion? Option A: It can be converted to α-ketoglutaric acid through the action of a 2-hydroxyglutarate dehydrogenase. Option B: The levo-isomer is rapidly converted to the biologically available methyl-tetrahydrofolate form, while the dextro form is slowly excreted by the kidneys. Option C: It must first cross the inner mitochondrial membrane into the mitochondrial matrix where it is carbamylated by this moleculetranscarbamylase in order to be converted to citrulline. Option D: It is converted into acetaldehyde by alcohol dehydrogenase and then into acetic acid by acetaldehyde dehydrogenase. " A 7498 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)CBr Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to tissue and metals. Option B: It is corrosive to metals in the presence of moisture and to tissue. Option C: It is corrosive to tin and mild steel. Option D: It is corrosive to metals and tissue. " D 24085 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: Cl[Hg]Cl Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to metals in the presence of moisture and to tissue. Option B: It is corrosive to tissue and metals. Option C: It is corrosive to metals and tissue. Option D: It is corrosive to mucous membranes. " D 8119 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCCNCC1 Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to metals and tissue. Option B: It is corrosive to tin and mild steel. Option C: It is corrosive to tissue and metals. Option D: It is corrosive to metals in the presence of moisture and to tissue. " A 700 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CO)N Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to metals in the presence of moisture and to tissue. Option B: It is corrosive to tin and mild steel. Option C: It may attack copper, brass, and rubber. Option D: It reacts slowly with metals causing mild corrosion. " C 6597 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)O)(Cl)Cl Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to metals and tissue. Option B: It is corrosive to metals in the presence of moisture and to tissue. Option C: It is corrosive to tissue and metals. Option D: It is corrosive to tin and mild steel. " A 656671 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]S(=O)S(=O)(=O)[O-].[Na+].[Na+] Question about this molecule: How is the corrosiveness of this molecule Option A: It is a highly corrosive mineral acid. Option B: It is corrosive to tissue and metals. Option C: It is a corrosive acid. Option D: It is corrosive to metals and tissue. " C 6421 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(Cl)(Cl)Cl)O Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to metals in the presence of moisture and to tissue. Option B: It is corrosive to metals and tissue. Option C: It is corrosive to tin and mild steel. Option D: It is corrosive to tissue and metals. " B 5976 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)N Question about this molecule: How is the corrosiveness of this molecule Option A: It is highly corrosive and irritating to the skin, eyes, and mucous membranes. Option B: It is corrosive to skin, eyes, and mucous membranes. Option C: The gas is corrosive and dissolves in water to form flammable, corrosive solutions. Option D: It is corrosive to metals in the presence of moisture and to tissue. " A 944 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N+](=O)(O)[O-] Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to metals and tissue. Option B: It is a highly corrosive mineral acid. Option C: It is corrosive to tissue and metals. Option D: It is a corrosive acid. " B 10430 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CC(=O)O Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to metals in the presence of moisture and to tissue. Option B: It is corrosive to tissue and metals. Option C: It is corrosive to metals and tissue. Option D: It is corrosive to tin and mild steel. " C 4 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CN)O Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to metals in the presence of moisture and to tissue. Option B: It is corrosive to tissue and metals. Option C: It is corrosive to metals and tissue. Option D: It is corrosive to tin and mild steel. " C 6590 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C(=O)O Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to metals and tissue. Option B: It is corrosive to tin and mild steel. Option C: It is corrosive to tissue and metals. Option D: It is corrosive to metals in the presence of moisture and to tissue. " A 637090 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C=C/C(=O)O Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to tissue and metals. Option B: It is corrosive to metals and tissue. Option C: It is corrosive to metals in the presence of moisture and to tissue. Option D: It is corrosive to tin and mild steel. " B 1489 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1Cl)Cl)OCCCC(=O)O Question about this molecule: How is the corrosiveness of this molecule Option A: It is slightly corrosive to iron. Option B: It is corrosive to metals in the presence of moisture and to tissue. Option C: It is corrosive to tissue and metals. Option D: It is corrosive to metals and tissue. " A 34526 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)C1=NC(=CC(=N1)OP(=S)(OC)OC)C Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to tin and mild steel. Option B: It is corrosive to metals and tissue. Option C: It is corrosive to metals in the presence of moisture and to tissue. Option D: It is corrosive to tissue and metals. " A 4093 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=C)C(=O)O Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to metals and tissue. Option B: It is corrosive to tin and mild steel. Option C: It is corrosive to tissue and metals. Option D: It is corrosive to metals in the presence of moisture and to tissue. " A 6811 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=O)OC2=O Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to metals in the presence of moisture and to tissue. Option B: It is corrosive to metals and tissue. Option C: It forms a corrosive solution when mixed with water. Option D: It is corrosive to tissue and metals. " C 5360835 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Ga] Question about this molecule: How is the corrosiveness of this molecule Option A: It decomposes on heating to produce toxic and corrosive fumes including hydrogen chloride and chlorine. Option B: The gas is corrosive and dissolves in water to form flammable, corrosive solutions. Option C: It is corrosive to skin but will numb rather than burn due to its anesthetic qualities. Option D: It may emit toxic fumes and form a corrosive alkaline solution with water when exposed to high temperatures. " D 30773 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC1=NC(=NC(=N1)Cl)NC(C)(C)C#N Question about this molecule: How is the corrosiveness of this molecule Option A: It can be very corrosive, depending on the concentration. Option B: It is corrosive to metals and tissue. Option C: It is non-corrosive when dry. Option D: It forms a corrosive solution when mixed with water. " C 996 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)O Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to skin but will numb rather than burn due to its anesthetic qualities. Option B: It is highly corrosive and irritating to the skin, eyes, and mucous membranes. Option C: The gas is corrosive and dissolves in water to form flammable, corrosive solutions. Option D: It is corrosive to skin, eyes, and mucous membranes. " A 612 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C(=O)O)O Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to metals and tissue. Option B: It is corrosive to tissue and metals. Option C: It is corrosive to tin and mild steel. Option D: It is corrosive to metals in the presence of moisture and to tissue. " A 6914 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1Cl)O)Cl)Cl Question about this molecule: How is the corrosiveness of this molecule Option A: The gas is corrosive and dissolves in water to form flammable, corrosive solutions. Option B: It decomposes on heating to produce toxic and corrosive fumes including hydrogen chloride and chlorine. Option C: It is corrosive to skin, eyes, and mucous membranes. Option D: It is highly corrosive and irritating to the skin, eyes, and mucous membranes. " B 1100 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OS(=O)O Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to tissue and metals. Option B: It is corrosive to tin and mild steel. Option C: It is corrosive to metals and tissue. Option D: It is corrosive to metals in the presence of moisture and to tissue. " C 6341 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN Question about this molecule: How is the corrosiveness of this molecule Option A: It is highly corrosive and irritating to the skin, eyes, and mucous membranes. Option B: It is corrosive to metals in the presence of moisture and to tissue. Option C: It is corrosive to the skin and eyes. Option D: It is corrosive to skin, eyes, and mucous membranes. " C 6422 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(F)(F)F)O Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to metals in the presence of moisture and to tissue. Option B: It is highly corrosive and irritating to the skin, eyes, and mucous membranes. Option C: It is corrosive to skin, eyes, and mucous membranes. Option D: The gas is corrosive and dissolves in water to form flammable, corrosive solutions. " C 24817 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: Cl[Zr](Cl)(Cl)Cl Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to tin and mild steel. Option B: It is corrosive to tissue and metals. Option C: It is corrosive to metals in the presence of moisture and to tissue. Option D: It is corrosive to metals and tissue. " C 176 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)O Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to metals and tissue. Option B: It is corrosive to tissue and metals. Option C: It is corrosive to metals in the presence of moisture and to tissue. Option D: It can be very corrosive, depending on the concentration. " D 6593 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)Cl)(Cl)Cl Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to metals and tissue. Option B: It is corrosive to tissue and metals. Option C: It is corrosive to metals in the presence of moisture and to tissue. Option D: It is corrosive to tin and mild steel. " A 300 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)O)Cl Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to tin and mild steel. Option B: It is corrosive to metals in the presence of moisture and to tissue. Option C: It is corrosive to tissue and metals. Option D: It is corrosive to metals and tissue. " D 1004 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OP(=O)(O)O Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to tissue and metals. Option B: It is corrosive to tin and mild steel. Option C: It is corrosive to metals and tissue. Option D: It is corrosive to metals in the presence of moisture and to tissue. " C 7991 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(=O)O Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to metals in the presence of moisture and to tissue. Option B: It is corrosive to tissue and metals. Option C: It is corrosive to tin and mild steel. Option D: It is corrosive to metals and tissue. " D 6259 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(=O)CBr Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to metals and tissue. Option B: It is corrosive to tissue and metals. Option C: It is corrosive to metals in the presence of moisture and to tissue. Option D: It reacts slowly with metals causing mild corrosion. " D 222 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: N Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to tissue and metals. Option B: It is corrosive to metals in the presence of moisture and to tissue. Option C: It is corrosive to tin and mild steel. Option D: It is corrosive to metals and tissue. " A 284 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)O Question about this molecule: How is the corrosiveness of this molecule Option A: It is corrosive to metals and tissue. Option B: It is corrosive to tin and mild steel. Option C: It is corrosive to tissue and metals. Option D: It is corrosive to metals in the presence of moisture and to tissue. " A 1146 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C Question about this molecule: How is the corrosiveness of this molecule Option A: It decomposes on heating to produce toxic and corrosive fumes including hydrogen chloride and chlorine. Option B: It is highly corrosive and irritating to the skin, eyes, and mucous membranes. Option C: The gas is corrosive and dissolves in water to form flammable, corrosive solutions. Option D: It is corrosive to skin, eyes, and mucous membranes. " C 11994820 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(/C=C/C1CCC2=C(O1)C=C(C(=C2C=O)O)CC=C(C)C)O Question about this molecule: Which kind of cytotoxic activity does this molecule have/exhibit? Option A: It exhibits cytotoxic activity against human cancer cell lines. Option B: It exhibits cytotoxic activity against a small panel of human tumour cell lines. Option C: It exhibits cytotoxic activity against human tumour cell lines. Option D: It exhibits cytotoxic activity towards several tumour cell lines. " D 44258704 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C=CC2=C1OC(=C(C2=O)OC)C3=CC(=C(C=C3)O)O)O Question about this molecule: Which kind of cytotoxic activity does this molecule have/exhibit? Option A: It exhibits cytotoxic activity against human cancer cell lines. Option B: It exhibits cytotoxic activity towards human cancer cell lines. Option C: It exhibits cytotoxic activity against human tumour cell lines. Option D: It exhibits cytotoxic activity against a small panel of human tumour cell lines. " A 9881423 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC2=C(C=C1)C3=C4N2C(=O)C=CC4=NC=C3 Question about this molecule: Which kind of cytotoxic activity does this molecule have/exhibit? Option A: It exhibits cytotoxic activity towards human cancer cell lines. Option B: It exhibits cytotoxic activity against human cancer cell lines. Option C: It exhibits cytotoxic activity against a small panel of human tumour cell lines. Option D: It exhibits cytotoxic activity against human tumour cell lines. " A 11482553 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC(=C1C(=O)OCC(=O)C[C@H](C)O)O)O Question about this molecule: Which kind of cytotoxic activity does this molecule have/exhibit? Option A: It exhibits cytotoxic activity towards human cancer cell lines. Option B: It exhibits cytotoxic activity against human cancer cell lines. Option C: It exhibits cytotoxic activity towards cancer cell lines. Option D: It exhibits cytotoxic activity against human tumour cell lines. " C 177338 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC2=CC(=CN=C2C(=C1)O)O Question about this molecule: Which kind of cytotoxic activity does this molecule have/exhibit? Option A: It exhibits cytotoxic activity against human cancer cell lines. Option B: It exhibits cytotoxic activity towards human cancer cell lines. Option C: It exhibits cytotoxic activity against a small panel of human tumour cell lines. Option D: It exhibits cytotoxic activity against human tumour cell lines. " D 11354606 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@@H]2CC[C@H]3C(=C)C[C@@H](O3)CC[C@]45C[C@@H]6[C@H](O4)[C@H]7[C@@H](O6)[C@@H](O5)[C@@H]8[C@@H](O7)CC[C@@H](O8)CC(=O)C[C@H]9[C@H](C[C@H](C1=C)O2)O[C@@H]([C@@H]9OC)C[C@@H](CN)O Question about this molecule: Which kind of cytotoxic activity does this molecule have/exhibit? Option A: It exhibits cytotoxic activity against human cancer cell lines. Option B: It exhibits cytotoxic activity towards cancer cell lines. Option C: It exhibits cytotoxic activity towards human cancer cell lines. Option D: It has cytotoxic activity against cancer cells. " D 297 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C Question about this molecule: What is the right information about this molecule's decomposition? Option A: It decomposes into a gaseous form when applied to wet soil. Option B: Older samples tend to acquire a yellow cast due to decomposition into oxides of nitrogen and water. Option C: It appears as a flammable gaseous mixture of straight chain hydrocarbons. Option D: It decomposes on heating to produce toxic and corrosive fumes including hydrogen chloride and chlorine. " C 135398658 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)NC(=N3)N Question about this molecule: What is the right information about this molecule's decomposition? Option A: It decomposes at 243-244 °C. Option B: It darkens and chars from approximately 482 °F. Option C: Decomposition begins at approximately 419 °F. Option D: It decomposes above 212 °F. " B 27455 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [NH4+].[NH4+].[O-]S(=O)(=O)[O-].[O-]S(=O)(=O)[O-].[Ni+2] Question about this molecule: What is the right information about this molecule's decomposition? Option A: It emits highly toxic fumes of metallic nickel, oxides of sulfur, and oxides of nitrogen when heated to decomposition. Option B: It may release gases and vapors such as hydrogen bromide, bromine, and carbon monoxide when heated to decomposition. Option C: Older samples tend to acquire a yellow cast due to decomposition into oxides of nitrogen and water. Option D: It decomposes on heating to produce toxic and corrosive fumes including hydrogen chloride and chlorine. " A 13838 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[Si](C)(C)N[Si](C)(C)C Question about this molecule: What is the right information about this molecule's decomposition? Option A: It may emit highly toxic nitrogen oxide fumes when heated to decomposition. Option B: It decomposes with emission of toxic oxides of nitrogen at high temperatures. Option C: It releases nitrogen gas when burned or charred. Option D: It produces toxic fumes when heated to decomposition. " A 10964 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C=O)C=O Question about this molecule: What is the right information about this molecule's decomposition? Option A: It produces toxic fumes when heated to decomposition. Option B: It may emit highly toxic nitrogen oxide fumes when heated to decomposition. Option C: It releases nitrogen gas when burned or charred. Option D: It produces MDA as a decomposition product. " D 67184 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC(=O)N(C1=O)Br Question about this molecule: What is the right information about this molecule's decomposition? Option A: It may emit highly toxic nitrogen oxide fumes when heated to decomposition. Option B: It gives off bromine over time. Option C: It releases nitrogen gas when burned or charred. Option D: It produces toxic fumes when heated to decomposition. " B 7955 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=NC(=NC(=N1)N)N)N Question about this molecule: What is the right information about this molecule's decomposition? Option A: It may emit highly toxic nitrogen oxide fumes when heated to decomposition. Option B: It releases nitrogen gas when burned or charred. Option C: It decomposes with emission of toxic oxides of nitrogen at high temperatures. Option D: It produces toxic fumes when heated to decomposition. " B 944 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N+](=O)(O)[O-] Question about this molecule: What is the right information about this molecule's decomposition? Option A: It may release gases and vapors such as hydrogen bromide, bromine, and carbon monoxide when heated to decomposition. Option B: It emits highly toxic fumes of metallic nickel, oxides of sulfur, and oxides of nitrogen when heated to decomposition. Option C: Older samples tend to acquire a yellow cast due to decomposition into oxides of nitrogen and water. Option D: It decomposes on heating to produce toxic and corrosive fumes including hydrogen chloride and chlorine. " C 20393 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)O Question about this molecule: What is the right information about this molecule's decomposition? Option A: It hydrolyzes to MEHP and subsequently to phthalate salts. Option B: It decomposes with emission of toxic oxides of nitrogen at high temperatures. Option C: It decomposes on heating to produce toxic and corrosive fumes including hydrogen chloride and chlorine. Option D: It decomposes into a gaseous form when applied to wet soil. " A 11715 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)CBr Question about this molecule: What is the right information about this molecule's decomposition? Option A: It decomposes on heating to produce toxic and corrosive fumes including hydrogen chloride and chlorine. Option B: It decomposes into a gaseous form when applied to wet soil. Option C: It decomposes with emission of toxic oxides of nitrogen at high temperatures. Option D: It decomposes to a black resinous mass on long standing. " D 9032 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C-]#N.[K+] Question about this molecule: What is the right information about this molecule's decomposition? Option A: It decomposes with emission of toxic oxides of nitrogen at high temperatures. Option B: It releases nitrogen gas when burned or charred. Option C: It produces toxic fumes when heated to decomposition. Option D: It may emit highly toxic nitrogen oxide fumes when heated to decomposition. " C 784 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OO Question about this molecule: What is the right information about this molecule's decomposition? Option A: It decomposes with emission of toxic oxides of nitrogen at high temperatures. Option B: It decomposes on heating to produce toxic and corrosive fumes including hydrogen chloride and chlorine. Option C: It decomposes readily to oxygen and water with release of heat. Option D: It decomposes by water to give sulfuric acid with evolution of heat. " C 1145 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+](C)(C)[O-] Question about this molecule: What is the right information about this molecule's decomposition? Option A: It may release gases and vapors such as hydrogen bromide, bromine, and carbon monoxide when heated to decomposition. Option B: It emits highly toxic fumes of metallic nickel, oxides of sulfur, and oxides of nitrogen when heated to decomposition. Option C: It decomposes on heating to produce toxic and corrosive fumes including hydrogen chloride and chlorine. Option D: It decomposes to trimethylamine (TMA), which is the main odorant that is characteristic of degrading seafood. " D 6497 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COS(=O)(=O)OC Question about this molecule: What is the right information about this molecule's decomposition? Option A: It decomposes on heating to produce toxic and corrosive fumes including hydrogen chloride and chlorine. Option B: It decomposes with emission of toxic oxides of nitrogen at high temperatures. Option C: It decomposes by water to give sulfuric acid with evolution of heat. Option D: It decomposes readily to oxygen and water with release of heat. " C 2788 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC2=C(C(=C(C=C2Cl)I)O)N=C1 Question about this molecule: What is the right information about this molecule's decomposition? Option A: It decomposes above 212 °F. Option B: Decomposition begins at approximately 419 °F. Option C: It decomposes at 243-244 °C. Option D: It decomposes at 178-179 °C. " D 7261 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)N)N Question about this molecule: What is the right information about this molecule's decomposition? Option A: It decomposes by water to give sulfuric acid with evolution of heat. Option B: It decomposes on heating to produce toxic and corrosive fumes including hydrogen chloride and chlorine. Option C: It decomposes with emission of toxic oxides of nitrogen at high temperatures. Option D: Older samples tend to acquire a yellow cast due to decomposition into oxides of nitrogen and water. " C 6914 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1Cl)O)Cl)Cl Question about this molecule: What is the right information about this molecule's decomposition? Option A: It emits highly toxic fumes of metallic nickel, oxides of sulfur, and oxides of nitrogen when heated to decomposition. Option B: It decomposes on heating to produce toxic and corrosive fumes including hydrogen chloride and chlorine. Option C: Older samples tend to acquire a yellow cast due to decomposition into oxides of nitrogen and water. Option D: It may release gases and vapors such as hydrogen bromide, bromine, and carbon monoxide when heated to decomposition. " B 135436526 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C(=N)N[N+](=O)[O-])N=O Question about this molecule: What is the right information about this molecule's decomposition? Option A: It decomposes at 178-179 °C. Option B: Decomposition begins at approximately 419 °F. Option C: It decomposes above 212 °F. Option D: It decomposes at 243-244 °C. " C 6375 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+](=O)[O-] Question about this molecule: What is the right information about this molecule's decomposition? Option A: It decomposes at 243-244 °C. Option B: It may violently decompose if intensely heated when contaminated. Option C: It decomposes at 178-179 °C. Option D: It decomposes above 212 °F. " B 3496 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)O)NCP(=O)(O)O Question about this molecule: What is the right information about this molecule's decomposition? Option A: Decomposition begins at approximately 419 °F. Option B: It decomposes above 212 °F. Option C: It darkens and chars from approximately 482 °F. Option D: It decomposes at 243-244 °C. " A 7839 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CBr)Br Question about this molecule: What is the right information about this molecule's decomposition? Option A: It decomposes on heating to produce toxic and corrosive fumes including hydrogen chloride and chlorine. Option B: It emits highly toxic fumes of metallic nickel, oxides of sulfur, and oxides of nitrogen when heated to decomposition. Option C: Older samples tend to acquire a yellow cast due to decomposition into oxides of nitrogen and water. Option D: It may release gases and vapors such as hydrogen bromide, bromine, and carbon monoxide when heated to decomposition. " D 8029 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=COC=C1 Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water. Option B: It is more dense than water. Option C: It is slightly less dense than water. Option D: It is somewhat less dense than water. " A 7762 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(=O)OCC Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat less dense than water. Option B: It is slightly less dense than water. Option C: It is less dense than water. Option D: It is more dense than water. " C 8025 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC=O Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water. Option B: It is slightly less dense than water. Option C: It is more dense than water. Option D: It is somewhat less dense than water. " A 280 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)=O Question about this molecule: What is the right information about this molecule's density? Option A: It is heavier than air. Option B: Lighter than air Option C: Relatively heavier than air Option D: It is less dense than air. " C 9731 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1N)F Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly denser than water. Option B: It is somewhat denser than water. Option C: It is denser than water. Option D: It is denser than air. " C 31246 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(=O)CCC Question about this molecule: What is the right information about this molecule's density? Option A: It is more dense than water. Option B: It is less dense than water. Option C: It is somewhat less dense than water. Option D: It is slightly less dense than water. " B 6113 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOS(=O)(=O)C Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat denser than water. Option B: It is slightly denser than water. Option C: It is denser than water. Option D: It is denser than air. " C 10907 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CC(C)(C)C Question about this molecule: What is the right information about this molecule's density? Option A: It is more dense than water. Option B: It is somewhat less dense than water. Option C: It is less dense than water. Option D: It is slightly less dense than water. " C 516902 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]Cl(=O)=O.[Na+] Question about this molecule: What is the right information about this molecule's density? Option A: Relatively heavier than air Option B: Lighter than air Option C: Heavier Option D: It is heavier than air. " C 24085 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: Cl[Hg]Cl Question about this molecule: What is the right information about this molecule's density? Option A: Density 5.4 g / cm3 Option B: Density is 8.0 lb/gal. Option C: Density is 6.7 lb/gal. Option D: Density is 2.633 g / cm3. " A 6328 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CI Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat denser than water. Option B: It is denser than air. Option C: It is denser than water. Option D: It is slightly denser than water. " C 10967 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(OCCl)Cl Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly denser than water. Option B: It is somewhat denser than water. Option C: It is denser than water. Option D: It is denser than air. " D 6569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)C Question about this molecule: What is the right information about this molecule's density? Option A: It is heavier than air. Option B: It is heavier than water. Option C: It is less dense than water. Option D: It is more dense than water. " A 297 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C Question about this molecule: What is the right information about this molecule's density? Option A: Relatively heavier than air Option B: Lighter than air Option C: It is heavier than air. Option D: It is less dense than air. " B 6589 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C(C)C Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat less dense than water. Option B: It is more dense than water. Option C: It is less dense than water. Option D: It is slightly less dense than water. " C 8470 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: B(OC)(OC)OC Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than air. Option B: It is somewhat denser than water. Option C: It is denser than water. Option D: It is slightly denser than water. " C 7840 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCBr Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat denser than water. Option B: It is slightly denser than water. Option C: It is denser than air. Option D: It is denser than water. " B 23953 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [SiH4] Question about this molecule: What is the right information about this molecule's density? Option A: Lighter than air Option B: It is heavier than air. Option C: It is less dense than air. Option D: Relatively heavier than air " A 957 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCO Question about this molecule: What is the right information about this molecule's density? Option A: It sinks in and mixes with water. Option B: It floats and mixes with water. Option C: It solidifies and floats on water. Option D: It floats on water. " D 6954 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1[N+](=O)[O-])O)[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than water and vapors are heavier than air. Option B: It is less dense than water and slightly soluble in water. Option C: The pure substance is denser than water (1.77 g cm-3). Option D: Density is denser than water and slightly soluble in water. " C 7903 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC[N+](=O)[O-] Question about this molecule: What is the right information about this molecule's density? Option A: It sinks in and mixes with water. Option B: Density is about the same as water. Option C: Density about the same as water. Option D: It has about the same density as water. " C 8103 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCO Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly less dense than water. Option B: It is more dense than water. Option C: It is somewhat less dense than water. Option D: It is less dense than water. " D 6184 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC=O Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat less dense than water. Option B: It is slightly less dense than water. Option C: It is less dense than water. Option D: It is more dense than water. " C 10129889 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Li+].[N+](=O)([O-])[O-] Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly denser than water. Option B: It is denser than air. Option C: It is somewhat denser than water. Option D: It is denser than water. " D 31260 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CCO Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly less dense than water. Option B: It is more dense than water. Option C: It is less dense than water. Option D: It is somewhat less dense than water. " C 145068 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N]=O Question about this molecule: What is the right information about this molecule's density? Option A: The vapors are heavier than air. Option B: The vapors are lighter than air. Option C: Vapors are heavier than air. Option D: It has vapors that are heavier than air. " C 6419 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)(Cl)Cl)(Cl)Cl Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than water. Option B: It is slightly denser than water. Option C: It is denser than air. Option D: It is somewhat denser than water. " A 13838 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[Si](C)(C)N[Si](C)(C)C Question about this molecule: What is the right information about this molecule's density? Option A: Vapors are heavier than air. Option B: The vapors are heavier than air. Option C: It has vapors that are heavier than air. Option D: The vapors are lighter than air. " A 7344 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C(C)O Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than water. Option B: It is denser than air. Option C: It is slightly denser than water. Option D: It is somewhat denser than water. " A 6658 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=C)C(=O)OC Question about this molecule: What is the right information about this molecule's density? Option A: It solidifies and floats on water. Option B: It floats on water. Option C: It sinks in and mixes with water. Option D: It floats and mixes with water. " B 24934 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-][Se](=O)[O-].[Na+].[Na+] Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly less dense than water. Option B: It is more dense than water. Option C: It is somewhat less dense than water. Option D: It is less dense than water. " B 8060 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCN Question about this molecule: What is the right information about this molecule's density? Option A: The vapors are lighter than air. Option B: Vapors are heavier than air. Option C: It has vapors that are heavier than air. Option D: The vapors are heavier than air. " B 8058 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly less dense than water. Option B: It is somewhat less dense than water. Option C: It is more dense than water. Option D: It is less dense than water. " D 7945 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)CC(C)C Question about this molecule: What is the right information about this molecule's density? Option A: It is more dense than water. Option B: It is somewhat less dense than water. Option C: It is less dense than water. Option D: It is slightly less dense than water. " C 179 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C(=O)C)O Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly denser than water. Option B: It is somewhat denser than water. Option C: It is denser than air. Option D: It is denser than water. " A 7367 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(Cl)(Cl)Cl Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water and slightly soluble in water. Option B: It is denser than water and vapors are heavier than air. Option C: Density is denser than water and slightly soluble in water. Option D: It is less dense than water and soluble in water. " B 6560 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CO Question about this molecule: What is the right information about this molecule's density? Option A: It is more dense than water. Option B: It is less dense than water. Option C: It is somewhat less dense than water. Option D: It is slightly less dense than water. " B 10903 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly less dense than water. Option B: It is more dense than water. Option C: It is less dense than water. Option D: It is somewhat less dense than water. " C 7997 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCOC(=O)C Question about this molecule: What is the right information about this molecule's density? Option A: It is more dense than water. Option B: It is slightly less dense than water. Option C: It is less dense than water. Option D: It is somewhat less dense than water. " C 6579 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC(=O)N Question about this molecule: What is the right information about this molecule's density? Option A: It is more dense than water. Option B: It is somewhat less dense than water. Option C: It is less dense than water. Option D: It is slightly less dense than water. " C 6568 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C)O Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water. Option B: It is somewhat less dense than water. Option C: It is slightly less dense than water. Option D: It is more dense than water. " A 6366 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=C(Cl)Cl Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than air. Option B: It is somewhat denser than water. Option C: It is slightly denser than water. Option D: It is denser than water. " D 5988 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@]2([C@H]([C@@H]([C@H](O2)CO)O)O)CO)O)O)O)O Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than water. Option B: It is slightly denser than water. Option C: It is somewhat denser than water. Option D: It is denser than air. " A 261 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC=O Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water. Option B: It is slightly less dense than water. Option C: It is somewhat less dense than water. Option D: It is more dense than water. " A 24589 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Be+2].[F-].[F-] Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than water. Option B: It is somewhat denser than water. Option C: It is slightly denser than water. Option D: It is denser than air. " A 7720 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(CC)CO Question about this molecule: What is the right information about this molecule's density? Option A: It is more dense than water. Option B: It is less dense than water. Option C: It is slightly less dense than water. Option D: It is somewhat less dense than water. " B 7852 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water. Option B: It is more dense than water. Option C: It is slightly less dense than water. Option D: It is somewhat less dense than water. " A 18430 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C(O1)CBr Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than water. Option B: It is slightly denser than water. Option C: It is denser than air. Option D: It is somewhat denser than water. " A 7342 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C(C)C Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water. Option B: It is somewhat less dense than water. Option C: It is slightly less dense than water. Option D: It is more dense than water. " A 7937 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NC(=CC=C1)C Question about this molecule: What is the right information about this molecule's density? Option A: It is more dense than water. Option B: It is somewhat less dense than water. Option C: It is slightly less dense than water. Option D: It is less dense than water. " D 15413 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)OC Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly less dense than water. Option B: It is less dense than water. Option C: It is more dense than water. Option D: It is somewhat less dense than water. " B 6575 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=C(Cl)Cl)Cl Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than water. Option B: It is somewhat denser than water. Option C: It is slightly denser than water. Option D: It is denser than air. " A 7501 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC1=CC=CC=C1 Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly less dense than water. Option B: It is less dense than water. Option C: It is somewhat less dense than water. Option D: It is more dense than water. " B 6782 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)COC(=O)C1=CC=CC=C1C(=O)OCC(C)C Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than air. Option B: It is somewhat denser than water. Option C: It is denser than water. Option D: It is slightly denser than water. " C 7902 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCO Question about this molecule: What is the right information about this molecule's density? Option A: It is more dense than water. Option B: It is somewhat less dense than water. Option C: It is less dense than water. Option D: It is slightly less dense than water. " C 11167 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN=C=S Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than air. Option B: It is denser than water. Option C: It is slightly denser than water. Option D: It is somewhat denser than water. " B 6228 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C=O Question about this molecule: What is the right information about this molecule's density? Option A: It is more dense than water. Option B: It is somewhat less dense than water. Option C: It is less dense than water. Option D: It is slightly less dense than water. " D 7002 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC2=CC=CC=C12 Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat denser than water. Option B: It is denser than air. Option C: It is slightly denser than water. Option D: It is denser than water. " D 6407 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)C(Cl)(Cl)Cl Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than air. Option B: It is denser than water. Option C: It is slightly denser than water. Option D: It is somewhat denser than water. " B 6629 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C1=CC=CC=C1)OO Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat denser than water. Option B: It is denser than air. Option C: It is slightly denser than water. Option D: It is denser than water. " D 946 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: N(=O)[O-] Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than air. Option B: It is somewhat denser than water. Option C: It is denser than water. Option D: It is slightly denser than water. " C 8857 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat less dense than water. Option B: It is slightly less dense than water. Option C: It is more dense than water. Option D: It is less dense than water. " D 8076 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOCCO Question about this molecule: What is the right information about this molecule's density? Option A: It is more dense than water. Option B: It is somewhat less dense than water. Option C: It is slightly less dense than water. Option D: It is less dense than water. " D 7967 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(=O)CC1 Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat less dense than water. Option B: It is slightly less dense than water. Option C: It is less dense than water. Option D: It is more dense than water. " C 5976 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)N Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat less dense than water. Option B: It is less dense than water. Option C: It is slightly less dense than water. Option D: It is more dense than water. " B 8038 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)COC(=O)C Question about this molecule: What is the right information about this molecule's density? Option A: It is more dense than water. Option B: It is slightly less dense than water. Option C: It is less dense than water. Option D: It is somewhat less dense than water. " C 8028 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCOC1 Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat less dense than water. Option B: It is more dense than water. Option C: It is slightly less dense than water. Option D: It is less dense than water. " D 8252 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC=C Question about this molecule: What is the right information about this molecule's density? Option A: The vapors are lighter than air. Option B: It is heavier than air. Option C: The vapors are heavier than air. Option D: It has vapors that are heavier than air. " C 3598 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly denser than water. Option B: It is denser than air. Option C: It is denser than water. Option D: It is somewhat denser than water. " C 6338 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCl Question about this molecule: What is the right information about this molecule's density? Option A: It is heavier than air. Option B: The vapors are lighter than air. Option C: The vapors are heavier than air. Option D: It has vapors that are heavier than air. " C 31373 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=C(Cl)Cl)(Cl)Cl Question about this molecule: What is the right information about this molecule's density? Option A: The vapors are lighter than air. Option B: The vapors are heavier than air. Option C: It is heavier than air. Option D: It has vapors that are heavier than air. " B 6324 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC Question about this molecule: What is the right information about this molecule's density? Option A: The vapors are heavier than air. Option B: It has vapors that are heavier than air. Option C: It is heavier than air. Option D: The vapors are lighter than air. " A 8109 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOCCCO Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water. Option B: It is more dense than water. Option C: It is slightly less dense than water. Option D: It is somewhat less dense than water. " A 7583 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)OC2=CC=CC=C2 Question about this molecule: What is the right information about this molecule's density? Option A: It sinks and mixes slowly with water. Option B: It floats and mixes with water. Option C: It sinks in and mixes with water. Option D: It may float or sink in water. " D 11 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCl)Cl Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than air. Option B: It is denser than water. Option C: It is somewhat denser than water. Option D: It is slightly denser than water. " B 949 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C1=CC=CC=C1 Question about this molecule: What is the right information about this molecule's density? Option A: It is more dense than water. Option B: It is less dense than water. Option C: It is somewhat less dense than water. Option D: It is slightly less dense than water. " B 12586 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1COCO1 Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than water. Option B: It is slightly denser than water. Option C: It is denser than air. Option D: It is somewhat denser than water. " B 7858 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCO Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly less dense than water. Option B: It is somewhat less dense than water. Option C: It is less dense than water. Option D: It is more dense than water. " C 311 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)O)C(CC(=O)O)(C(=O)O)O Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than water. Option B: It is slightly denser than water. Option C: It is somewhat denser than water. Option D: It is denser than air. " A 1068 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CSC Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat less dense than water. Option B: It is more dense than water. Option C: It is slightly less dense than water. Option D: It is less dense than water. " D 7409 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C1=CC=CC=C1)O Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water. Option B: It is slightly less dense than water. Option C: It is more dense than water. Option D: It is somewhat less dense than water. " A 8113 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CO)NCCO Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly denser than water. Option B: It is somewhat denser than water. Option C: It is denser than air. Option D: It is denser than water. " D 5460467 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Be] Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly denser than water. Option B: It is denser than air. Option C: It is somewhat denser than water. Option D: It is denser than water. " D 31261 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)CC(=O)C Question about this molecule: What is the right information about this molecule's density? Option A: It is more dense than water. Option B: It is less dense than water. Option C: It is somewhat less dense than water. Option D: It is slightly less dense than water. " B 7865 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC=O Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat less dense than water. Option B: It is more dense than water. Option C: It is slightly less dense than water. Option D: It is less dense than water. " D 6363 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)N Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat less dense than water. Option B: It is more dense than water. Option C: It is less dense than water. Option D: It is slightly less dense than water. " C 7497 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCO Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly less dense than water. Option B: It is more dense than water. Option C: It is somewhat less dense than water. Option D: It is less dense than water. " D 6558 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CN Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat less dense than water. Option B: It is slightly less dense than water. Option C: It is more dense than water. Option D: It is less dense than water. " D 8370 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=C(C(=C(C(=C1Cl)Cl)Cl)Cl)Cl)Cl Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than air. Option B: It is slightly denser than water. Option C: It is denser than water. Option D: It is somewhat denser than water. " C 527 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC=O Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat less dense than water. Option B: It is more dense than water. Option C: It is less dense than water. Option D: It is slightly less dense than water. " C 12021 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)OC Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than water. Option B: It is denser than air. Option C: It is somewhat denser than water. Option D: It is slightly denser than water. " A 3102 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(=O)C2=CC=CC=C2 Question about this molecule: What is the right information about this molecule's density? Option A: It floats and mixes with water. Option B: It sinks and mixes slowly with water. Option C: It may float or sink in water. Option D: It sinks in and mixes with water. " C 8094 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCC(=O)O Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat less dense than water. Option B: It is slightly less dense than water. Option C: It is more dense than water. Option D: It is less dense than water. " D 2879 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)O Question about this molecule: What is the right information about this molecule's density? Option A: It sinks in and mixes slowly with water. Option B: It floats and mixes with water. Option C: It sinks and mixes slowly with water. Option D: It sinks in and mixes with water. " C 6943 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C1=CC=CC=C1O Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water. Option B: It is more dense than water. Option C: It is somewhat less dense than water. Option D: It is slightly less dense than water. " A 24385 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: Cl[Ni]Cl Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than air. Option B: It is somewhat denser than water. Option C: It is denser than water. Option D: It is slightly denser than water. " C 244 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)CO Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly denser than water. Option B: It is denser than water. Option C: It is somewhat denser than water. Option D: It is denser than air. " A 24414 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]S(=O)(=O)[O-].[Ba+2] Question about this molecule: What is the right information about this molecule's density? Option A: Density: 4.25 -4.5 g cm-3. Option B: Density is 2.633 g / cm3. Option C: Density is 6.7 lb/gal. Option D: Density 5.4 g / cm3 " A 6720 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=C(C(=C(C(=C1Cl)Cl)Cl)Cl)Cl)[N+](=O)[O-] Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat denser than water. Option B: It is slightly denser than water. Option C: It is denser than water. Option D: It is denser than air. " C 948 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N-]=[N+]=O Question about this molecule: What is the right information about this molecule's density? Option A: The vapors are heavier than air. Option B: It is heavier than air. Option C: The vapors are lighter than air. Option D: It has vapors that are heavier than air. " D 590836 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCC(C)C Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than water. Option B: It is somewhat denser than water. Option C: It is denser than air. Option D: It is slightly denser than water. " A 4 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CN)O Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water and soluble in water. Option B: It is soluble in water and less dense than water. Option C: It is less dense than water and insoluble in water. Option D: It is insoluble in water and less dense than water. " A 7918 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)OC(=O)C Question about this molecule: What is the right information about this molecule's density? Option A: It has a density of 5.7 lb/gal. Option B: Its density is 9.0 lb/gal. Option C: The density is 14 lb/gal. Option D: Its density is 6.5 lb/gal. " B 7239 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)Cl)Cl Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water and insoluble in water. Option B: It is denser than water and soluble in water. Option C: It is less dense than water and soluble in water. Option D: It is denser than water and insoluble in water. " D 13190 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCC=C Question about this molecule: What is the right information about this molecule's density? Option A: It is insoluble in water and less dense than water. Option B: It is less dense than water and insoluble in water. Option C: It is soluble in water and less dense than water. Option D: It is less dense than water and soluble in water. " B 6574 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)Cl)Cl Question about this molecule: What is the right information about this molecule's density? Option A: It is insoluble in water and denser than water. Option B: It is insoluble in water and less dense than water. Option C: It is insoluble in water and slightly denser than water. Option D: It is slightly soluble in water and denser than water. " C 241 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=CC=C1 Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water and slightly soluble in water. Option B: It is less dense than water and soluble in water. Option C: It is less dense than water and insoluble in water. Option D: It is soluble in water and less dense than water. " A 8209 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCCCO Question about this molecule: What is the right information about this molecule's density? Option A: It solidifies and floats on water. Option B: It floats on water. Option C: It sinks in and mixes with water. Option D: It floats and mixes with water. " A 7635 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(CC)COC(=O)C Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water and insoluble in water. Option B: It is less dense than water and soluble in water. Option C: It is insoluble in water and less dense than water. Option D: It is soluble in water and less dense than water. " C 6544 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=O)CC(C1)(C)C Question about this molecule: What is the right information about this molecule's density? Option A: It is insoluble in water and less dense than water. Option B: It is less dense than water and insoluble in water. Option C: It is soluble in water and less dense than water. Option D: It is less dense than water and soluble in water. " B 7361 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=COC(=C1)CO Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than water. Option B: It is somewhat denser than water. Option C: It is denser than air. Option D: It is slightly denser than water. " A 62329 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=C(C(=C1[N+](=O)[O-])C(C)(C)C)[N+](=O)[O-])C)[N+](=O)[O-] Question about this molecule: What is the right information about this molecule's density? Option A: It is insoluble in water and slightly denser than water. Option B: It is insoluble in water and denser than water. Option C: It is insoluble in water and less dense than water. Option D: It is slightly soluble in water and denser than water. " B 702 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCO Question about this molecule: What is the right information about this molecule's density? Option A: Its density is 6.5 lb/gal. Option B: It has a density of 5.7 lb/gal. Option C: Its density is 9.0 lb/gal. Option D: The density is 14 lb/gal. " A 6354 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CO1 Question about this molecule: What is the right information about this molecule's density? Option A: It is soluble in water and less dense than water. Option B: It is less dense than water and soluble in water. Option C: It is a liquid that is less dense than water. Option D: It is insoluble in water and less dense than water. " C 23938 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Pd] Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than water and vapors are heavier than air. Option B: It is less dense than water (7.2 lb/gal) and insoluble in water. Option C: It is less dense than water with a density of 7.0 lb/gal. Option D: It has the lowest melting point and is the least dense of platinum group metals. " D 7047 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC=N2 Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly denser than water. Option B: It is somewhat denser than water. Option C: It is denser than water. Option D: It is denser than air. " A 7847 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC=O Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than water and vapors are heavier than air. Option B: It is less dense than water (7.2 lb/gal) and insoluble in water. Option C: It is less dense than water with a density of 7.0 lb/gal. Option D: Density is denser than water and slightly soluble in water. " C 7362 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=COC(=C1)C=O Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than water and soluble in water. Option B: It is denser than water and insoluble in water. Option C: It is less dense than water and soluble in water. Option D: It is less dense than water and insoluble in water. " A 637090 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C=C/C(=O)O Question about this molecule: What is the right information about this molecule's density? Option A: It is soluble in water and less dense than water. Option B: It is insoluble in water and less dense than water. Option C: It is less dense than water and soluble in water. Option D: It is less dense than water and insoluble in water. " A 5569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN(CCC)C1=C(C=C(C=C1[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-] Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat denser than water. Option B: It is denser than water. Option C: It is slightly denser than water. Option D: It is denser than air. " B 13387 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CCCC1=O Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly denser than water. Option B: It is somewhat denser than water. Option C: It is denser than air. Option D: It is denser than water. " D 169132 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(CC(CC(C1)(C)CN=C=O)N=C=O)C Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly denser than water. Option B: It is somewhat denser than water. Option C: It is denser than air. Option D: It is denser than water. " A 7775 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC(=O)OCC(C)C Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat less dense than water. Option B: It is less dense than water. Option C: It is more dense than water. Option D: It is slightly less dense than water. " B 31253 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCCC(=C)C=C)C Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly less dense than water. Option B: It is more dense than water. Option C: It is less dense than water. Option D: It is somewhat less dense than water. " C 7895 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(=O)C Question about this molecule: What is the right information about this molecule's density? Option A: It is more dense than water. Option B: It is somewhat less dense than water. Option C: It is less dense than water. Option D: It is slightly less dense than water. " C 9253 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCCC1 Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water. Option B: It is more dense than water. Option C: It is somewhat less dense than water. Option D: It is slightly less dense than water. " A 5565 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CNCCNCCN)N Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly less dense than water. Option B: It is somewhat less dense than water. Option C: It is less dense than water. Option D: It is more dense than water. " C 6276 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCO Question about this molecule: What is the right information about this molecule's density? Option A: It is more dense than water. Option B: It is less dense than water. Option C: It is slightly less dense than water. Option D: It is somewhat less dense than water. " B 7965 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(CC1)N Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly less dense than water. Option B: It is more dense than water. Option C: It is less dense than water. Option D: It is somewhat less dense than water. " C 5144 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCC1=CC2=C(C=C1)OCO2 Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat denser than water. Option B: It is denser than water. Option C: It is slightly denser than water. Option D: It is denser than air. " B 7095 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2=CC=CC=C2 Question about this molecule: What is the right information about this molecule's density? Option A: It is more dense than water. Option B: It is less dense than water. Option C: It is heavier than air. Option D: It is heavier than water. " C 7843 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water. Option B: It is heavier than air. Option C: It is more dense than water. Option D: It is heavier than water. " B 4093 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=C)C(=O)O Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water. Option B: It is more dense than water. Option C: It is slightly less dense than water. Option D: It is somewhat less dense than water. " A 7618 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CO)N(CCO)CCO Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly denser than water. Option B: It is somewhat denser than water. Option C: It is denser than water. Option D: It is denser than air. " C 31374 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)N(C)C Question about this molecule: What is the right information about this molecule's density? Option A: It sinks in and mixes with water. Option B: It floats and mixes with water. Option C: It sinks and mixes slowly with water. Option D: It has about the same density as water. " D 8091 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCC(=O)OC Question about this molecule: What is the right information about this molecule's density? Option A: It floats and mixes with water. Option B: It has about the same density as water. Option C: It sinks in and mixes with water. Option D: It sinks and mixes slowly with water. " B 6385 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)N Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water. Option B: It is somewhat less dense than water. Option C: It is slightly less dense than water. Option D: It is more dense than water. " A 8846 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOC(=O)C=C Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly less dense than water. Option B: It is somewhat less dense than water. Option C: It is less dense than water. Option D: It is more dense than water. " B 6386 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)O Question about this molecule: What is the right information about this molecule's density? Option A: It sinks in and mixes slowly with water. Option B: It sinks and mixes slowly with water. Option C: It floats and mixes with water. Option D: It sinks in and mixes with water. " C 2723923 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)[O-].[NH4+] Question about this molecule: What is the right information about this molecule's density? Option A: It sinks in and mixes with water. Option B: It sinks in and mixes slowly with water. Option C: It floats and mixes with water. Option D: It sinks and mixes slowly with water. " D 7846 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC#C Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than air. Option B: It is somewhat denser than water. Option C: It is slightly denser than water. Option D: It is denser than water. " A 8030 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CSC=C1 Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat denser than water. Option B: It is slightly denser than water. Option C: It is denser than water. Option D: It is denser than air. " B 22311 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CCC(CC1)C(=C)C Question about this molecule: What is the right information about this molecule's density? Option A: It has a density of 5.7 lb/gal. Option B: It has a density of 15.0 lb/gal. Option C: Its density is 6.5 lb/gal. Option D: It has a density of about 7.2 lb/gal. " D 6389 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(F)(Cl)(Cl)Cl Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than air. Option B: It is slightly denser than water. Option C: It is somewhat denser than water. Option D: It is denser than water. " D 11761 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=CC=C1)[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than water. Option B: It is slightly denser than water. Option C: It is denser than air. Option D: It is somewhat denser than water. " A 56841936 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O Question about this molecule: What is the right information about this molecule's density? Option A: Density is 2.633 g / cm3. Option B: It has a density of 2.65 g/cm3. Option C: Density is 6.7 lb/gal. Option D: Density 5.4 g / cm3 " B 5971 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCN=C=S Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than water. Option B: It is slightly denser than water. Option C: It is somewhat denser than water. Option D: It is denser than air. " B 7964 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)Cl Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly denser than water. Option B: It is denser than air. Option C: It is somewhat denser than water. Option D: It is denser than water. " C 7485 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly denser than water. Option B: It is denser than air. Option C: It is denser than water. Option D: It is somewhat denser than water. " C 8071 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCOC Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly less dense than water. Option B: It is somewhat less dense than water. Option C: It is less dense than water. Option D: It is more dense than water. " C 996 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)O Question about this molecule: What is the right information about this molecule's density? Option A: It is heavier than water. Option B: It is heavier than air. Option C: It is more dense than water. Option D: It is less dense than water. " B 7150 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)C1=CC=CC=C1 Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat denser than water. Option B: It is denser than air. Option C: It is denser than water. Option D: It is slightly denser than water. " C 7410 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C1=CC=CC=C1 Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly soluble in water and denser than water. Option B: It is insoluble in water and denser than water. Option C: It is insoluble in water and less dense than water. Option D: It is insoluble in water and slightly denser than water. " A 6654 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CCC2CC1C2(C)C Question about this molecule: What is the right information about this molecule's density? Option A: It is soluble in water and less dense than water. Option B: It is insoluble in water and less dense than water. Option C: It is less dense than water and soluble in water. Option D: It is less dense than water and insoluble in water. " D 6559 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C#N Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly less dense than water. Option B: It is more dense than water. Option C: It is less dense than water. Option D: It is somewhat less dense than water. " C 8082 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCNCC1 Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water and insoluble in water. Option B: It is less dense than water and soluble in water. Option C: It is less dense than water, but miscible in water. Option D: It is less dense than water and slightly soluble in water. " C 7298 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(C1)O Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat less dense than water. Option B: It is slightly less dense than water. Option C: It is more dense than water. Option D: It is less dense than water. " B 6591 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)Cl)(Cl)Cl Question about this molecule: What is the right information about this molecule's density? Option A: It is soluble in water and less dense than water. Option B: It is a dense liquid that does not burn easily. Option C: It is a liquid that is less dense than water. Option D: It is insoluble in water and less dense than water. " B 638011 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC/C(=C/C=O)/C)C Question about this molecule: What is the right information about this molecule's density? Option A: It is insoluble in water and less dense than water. Option B: It is less dense than water and soluble in water. Option C: It is soluble in water and less dense than water. Option D: It is less dense than water and insoluble in water. " D 6511 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[Pb](CC)(CC)CC Question about this molecule: What is the right information about this molecule's density? Option A: Its density is 9.0 lb/gal. Option B: Its density is 6.5 lb/gal. Option C: The density is 14 lb/gal. Option D: It has a density of 5.7 lb/gal. " C 8133 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOCCO Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat less dense than water. Option B: It is slightly less dense than water. Option C: It is less dense than water. Option D: It is more dense than water. " C 9086 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CN)CO Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water. Option B: It is slightly less dense than water. Option C: It is more dense than water. Option D: It is somewhat less dense than water. " A 15450 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CCCCCO Question about this molecule: What is the right information about this molecule's density? Option A: It is soluble in water and less dense than water. Option B: It is less dense than water and soluble in water. Option C: It is insoluble in water and less dense than water. Option D: It is less dense than water and insoluble in water. " D 180 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water. Option B: It is slightly less dense than water. Option C: It is more dense than water. Option D: It is somewhat less dense than water. " A 7288 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)CC Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly less dense than water. Option B: It is less dense than water. Option C: It is more dense than water. Option D: It is somewhat less dense than water. " B 8130 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCC=O Question about this molecule: What is the right information about this molecule's density? Option A: It is insoluble in water and less dense than water. Option B: It is soluble in water and less dense than water. Option C: It is less dense than water and soluble in water. Option D: It is less dense than water and insoluble in water. " A 8141 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCC Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water and insoluble in water. Option B: It is insoluble in water and less dense than water. Option C: It is soluble in water and less dense than water. Option D: It is less dense than water and soluble in water. " B 1140 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1 Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water (7.2 lb/gal) and insoluble in water. Option B: It is less dense than water with a density of 7.0 lb/gal. Option C: Density is denser than water and slightly soluble in water. Option D: It is denser than water and vapors are heavier than air. " A 6561 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C=O Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water and insoluble in water. Option B: It is soluble in water and less dense than water. Option C: It is insoluble in water and less dense than water. Option D: It is less dense than water and soluble in water. " A 24393 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]S(=O)(=O)[O-].[Fe+2] Question about this molecule: What is the right information about this molecule's density? Option A: It has a density of about 7.2 lb/gal. Option B: It has a density of 5.7 lb/gal. Option C: It has a density of 15.0 lb/gal. Option D: Its density is 6.5 lb/gal. " C 11614 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOC=O Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly less dense than water. Option B: It is less dense than water. Option C: It is more dense than water. Option D: It is somewhat less dense than water. " B 713 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)N Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than water. Option B: It is somewhat denser than water. Option C: It is denser than air. Option D: It is slightly denser than water. " A 7242 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1N Question about this molecule: What is the right information about this molecule's density? Option A: It sinks and mixes slowly with water. Option B: It floats and mixes with water. Option C: It sinks in and mixes with water. Option D: It has about the same density as water. " D 246728 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC(=O)CC Question about this molecule: What is the right information about this molecule's density? Option A: Its vapors are denser than air. Option B: It has vapors that are heavier than air. Option C: The vapors are heavier than air. Option D: It is denser than water and vapors are heavier than air. " A 3283 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOCC Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly less dense than water. Option B: It is somewhat less dense than water. Option C: It is more dense than water. Option D: It is less dense than water. " D 8892 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC(=O)O Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water. Option B: It is more dense than water. Option C: It is somewhat less dense than water. Option D: It is slightly less dense than water. " A 6849 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC=C2[N+](=O)[O-] Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat denser than water. Option B: It is denser than air. Option C: It is denser than water. Option D: It is slightly denser than water. " C 24502 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-][Cr](=O)(=O)O[Cr](=O)(=O)[O-].[K+].[K+] Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than air. Option B: It is somewhat denser than water. Option C: It is slightly denser than water. Option D: It is denser than water. " D 14213 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(=O)[O-])[O-].[NH4+].[NH4+] Question about this molecule: What is the right information about this molecule's density? Option A: It floats and mixes with water. Option B: It sinks in and mixes with water. Option C: It sinks and mixes slowly with water. Option D: It sinks in and mixes slowly with water. " C 4169 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC1=CC=CC(=C1N(C(C)COC)C(=O)CCl)C Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat denser than water. Option B: It is denser than water. Option C: It is denser than air. Option D: It is slightly denser than water. " B 6337 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCl Question about this molecule: What is the right information about this molecule's density? Option A: It is more dense than water. Option B: It is less dense than water. Option C: It is slightly less dense than water. Option D: It is somewhat less dense than water. " B 6781 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C1=CC=CC=C1C(=O)OCC Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water. Option B: It is slightly less dense than water. Option C: It is somewhat less dense than water. Option D: It is more dense than water. " D 7515 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC1=CC=CC=C1 Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than water. Option B: It is somewhat denser than water. Option C: It is denser than air. Option D: It is slightly denser than water. " A 8003 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat less dense than water. Option B: It is slightly less dense than water. Option C: It is more dense than water. Option D: It is less dense than water. " D 6341 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN Question about this molecule: What is the right information about this molecule's density? Option A: It has a density of 15.0 lb/gal. Option B: It has a density of 5.7 lb/gal. Option C: It has a density of about 7.2 lb/gal. Option D: Its density is 6.5 lb/gal. " B 8019 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCO Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat less dense than water. Option B: It is slightly less dense than water. Option C: It is more dense than water. Option D: It is less dense than water. " D 23670523 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1N)[As](=O)(O)[O-].[Na+] Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat denser than water. Option B: It is denser than air. Option C: It is denser than water. Option D: It is slightly denser than water. " D 6422 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(F)(F)F)O Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than air. Option B: It is denser than water. Option C: It is somewhat denser than water. Option D: It is slightly denser than water. " B 6570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C=C Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water. Option B: It is somewhat less dense than water. Option C: It is more dense than water. Option D: It is slightly less dense than water. " A 6423 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([N+](=O)[O-])(Cl)(Cl)Cl Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than air. Option B: It is somewhat denser than water. Option C: It is denser than water. Option D: It is slightly denser than water. " C 8174 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCO Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water. Option B: It is more dense than water. Option C: It is slightly less dense than water. Option D: It is somewhat less dense than water. " A 264 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(=O)O Question about this molecule: What is the right information about this molecule's density? Option A: Its density is 6.5 lb/gal. Option B: Density is 10.0 lb/gal. Option C: Density is 8.0 lb/gal. Option D: Density is 6.7 lb/gal. " C 152119 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OP(=S)(O)S Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than water. Option B: It is slightly denser than water. Option C: It is somewhat denser than water. Option D: It is denser than air. " A 7855 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC#N Question about this molecule: What is the right information about this molecule's density? Option A: Density is 8.0 lb/gal. Option B: Density is 6.7 lb/gal. Option C: Its density is 6.5 lb/gal. Option D: Density is 10.0 lb/gal. " B 679 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CS(=O)C Question about this molecule: What is the right information about this molecule's density? Option A: The vapors are lighter than air. Option B: It has vapors that are heavier than air. Option C: The vapors are heavier than air. Option D: Vapors are heavier than air. " D 8758 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)O)N(CC(=O)O)CC(=O)O Question about this molecule: What is the right information about this molecule's density? Option A: It sinks in and mixes with water. Option B: It sinks in and mixes slowly with water. Option C: It floats and mixes with water. Option D: It sinks and mixes slowly with water. " A 6375 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+](=O)[O-] Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than air. Option B: It is slightly denser than water. Option C: It is denser than water. Option D: It is somewhat denser than water. " C 6342 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC#N Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly less dense than water. Option B: It is somewhat less dense than water. Option C: It is less dense than water. Option D: It is more dense than water. " C 8078 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCCCC1 Question about this molecule: What is the right information about this molecule's density? Option A: It has vapors that are heavier than air. Option B: The vapors are heavier than air. Option C: The vapors are lighter than air. Option D: Vapors are heavier than air. " D 6327 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCl Question about this molecule: What is the right information about this molecule's density? Option A: It is more dense than water. Option B: It is less dense than water. Option C: It is heavier than air. Option D: It is heavier than water. " C 8086 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CNCC(C)O)O Question about this molecule: What is the right information about this molecule's density? Option A: Liquid floats and mixes with water. Option B: It sinks and mixes slowly with water. Option C: It floats and mixes with water. Option D: It sinks in and mixes with water. " A 300 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)O)Cl Question about this molecule: What is the right information about this molecule's density? Option A: It sinks in water. Option B: It sinks in and mixes with water. Option C: It floats and mixes with water. Option D: It may float or sink in water. " A 6351 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC1 Question about this molecule: What is the right information about this molecule's density? Option A: The vapors are lighter than air. Option B: Vapors are heavier than air. Option C: The vapors are heavier than air. Option D: It has vapors that are heavier than air. " B 3024 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Br)Br Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly denser than water. Option B: It is denser than air. Option C: It is somewhat denser than water. Option D: It is denser than water. " D 62672 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Be+2].O.O.O.O.[O-]S(=O)(=O)[O-] Question about this molecule: What is the right information about this molecule's density? Option A: It floats and mixes with water. Option B: It may float or sink in water. Option C: It sinks in water. Option D: It sinks in and mixes with water. " C 7416 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: What is the right information about this molecule's density? Option A: Density is 10.0 lb/gal. Option B: Density is 8.0 lb/gal. Option C: Density is 6.7 lb/gal. Option D: Its density is 6.5 lb/gal. " A 9584 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)N)F Question about this molecule: What is the right information about this molecule's density? Option A: It sinks in and mixes slowly with water. Option B: It sinks and mixes slowly with water. Option C: It floats and mixes with water. Option D: It sinks in and mixes with water. " A 7848 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCS Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat less dense than water. Option B: It is less dense than water. Option C: It is slightly less dense than water. Option D: It is more dense than water. " B 12228 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN=C=O Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than water. Option B: It is somewhat denser than water. Option C: It is slightly denser than water. Option D: It is denser than air. " A 31256 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)CC(C)(C)O Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat less dense than water. Option B: It is slightly less dense than water. Option C: It is more dense than water. Option D: It is less dense than water. " D 11137 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC(=C1)O)[N+](=O)[O-] Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than water. Option B: It is denser than air. Option C: It is somewhat denser than water. Option D: It is slightly denser than water. " A 342 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC=C1)O Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than air. Option B: It is slightly denser than water. Option C: It is somewhat denser than water. Option D: It is denser than water. " D 5943 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)(Cl)(Cl)Cl Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than water. Option B: It is somewhat denser than water. Option C: It is denser than air. Option D: It is slightly denser than water. " A 338 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)C(=O)O)O Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly denser than water. Option B: It is denser than water. Option C: It is somewhat denser than water. Option D: It is denser than air. " B 7505 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C#N Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than water. Option B: It is denser than air. Option C: It is somewhat denser than water. Option D: It is slightly denser than water. " A 6115 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)N Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly denser than water. Option B: It is denser than air. Option C: It is denser than water. Option D: It is somewhat denser than water. " C 454 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCC=O Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water. Option B: It is somewhat less dense than water. Option C: It is slightly less dense than water. Option D: It is more dense than water. " A 8640 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC=C2N Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly denser than water. Option B: It is denser than water. Option C: It is denser than air. Option D: It is somewhat denser than water. " B 281 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C-]#[O+] Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than air. Option B: It is less dense than water. Option C: It is slightly less dense than water. Option D: It is somewhat less dense than water. " A 240 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C=O Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat denser than water. Option B: It is denser than air. Option C: It is denser than water. Option D: It is slightly denser than water. " C 11638 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CF Question about this molecule: What is the right information about this molecule's density? Option A: It is more dense than water. Option B: It is heavier than water. Option C: It is heavier than air. Option D: It is less dense than water. " C 931 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C=CC=CC2=C1 Question about this molecule: What is the right information about this molecule's density? Option A: It is denser than air. Option B: It is slightly denser than water. Option C: It is denser than water. Option D: It is somewhat denser than water. " C 4420 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=O)(OC)OC(C(Cl)(Cl)Br)Br Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly denser than water. Option B: It is somewhat denser than water. Option C: It is denser than water. Option D: It is denser than air. " C 650 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C(=O)C Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly less dense than water. Option B: It is more dense than water. Option C: It is less dense than water. Option D: It is somewhat less dense than water. " C 6294 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat denser than water. Option B: It is slightly denser than water. Option C: It is denser than water. Option D: It is denser than air. " C 9033 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN1 Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat less dense than water. Option B: It is slightly less dense than water. Option C: It is less dense than water. Option D: It is more dense than water. " C 7839 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CBr)Br Question about this molecule: What is the right information about this molecule's density? Option A: It is heavier than water. Option B: It is heavier than air. Option C: It is more dense than water. Option D: It is less dense than water. " A 1322 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNNC Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat less dense than water. Option B: It is slightly less dense than water. Option C: It is more dense than water. Option D: It is less dense than water. " D 8063 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC=O Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water. Option B: It is somewhat less dense than water. Option C: It is more dense than water. Option D: It is slightly less dense than water. " A 8900 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCC Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water. Option B: It is more dense than water. Option C: It is somewhat less dense than water. Option D: It is slightly less dense than water. " A 31264 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1OC(OC(O1)C)C Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water. Option B: It is slightly less dense than water. Option C: It is somewhat less dense than water. Option D: It is more dense than water. " A 8037 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCN(C)C Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly less dense than water. Option B: It is more dense than water. Option C: It is less dense than water. Option D: It is somewhat less dense than water. " C 8452 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(=O)C1 Question about this molecule: What is the right information about this molecule's density? Option A: It is slightly less dense than water. Option B: It is somewhat less dense than water. Option C: It is more dense than water. Option D: It is less dense than water. " D 8051 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC(=O)C Question about this molecule: What is the right information about this molecule's density? Option A: It is somewhat less dense than water. Option B: It is less dense than water. Option C: It is slightly less dense than water. Option D: It is more dense than water. " B 783 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [HH] Question about this molecule: What is the right information about this molecule's density? Option A: It is heavier than air. Option B: It has vapors that are heavier than air. Option C: The vapors are heavier than air. Option D: The vapors are lighter than air. " D 7346 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C(=O)OC(=O)C(C)C Question about this molecule: What is the right information about this molecule's density? Option A: It has vapors that are heavier than air. Option B: The vapors are lighter than air. Option C: The vapors are heavier than air. Option D: It is heavier than air. " C 24437 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]S(=O)[O-].[Na+].[Na+] Question about this molecule: What is the right information about this molecule's density? Option A: Density is 8.0 lb/gal. Option B: Density is 2.633 g / cm3. Option C: Density is 6.7 lb/gal. Option D: Density 5.4 g / cm3 " B 2537 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C2CCC1(C(=O)C2)C)C Question about this molecule: What is the right information about this molecule's density? Option A: Density about the same as water. Option B: It sinks in and mixes with water. Option C: It has about the same density as water. Option D: Density is about the same as water. " D 3301 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CN)N Question about this molecule: What is the right information about this molecule's density? Option A: It has vapors that are heavier than air. Option B: The vapors are heavier than air. Option C: Vapors are heavier than air. Option D: The vapors are lighter than air. " C 12232 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CSSC Question about this molecule: What is the right information about this molecule's density? Option A: It is less dense than water and soluble in water. Option B: It is less dense than water and insoluble in water. Option C: Density is denser than water and slightly soluble in water. Option D: It is less dense than water and slightly soluble in water. " C 5121662 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCOS(=O)(=O)[O-] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has shown similar efficacy to theophylline in the treatment of asthma, but with significantly fewer side effects in animal and human studies. Option B: It can induce morphological changes of phytoplankton Scenedesmus gutwinskii. Option C: It does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. Option D: It is known to exacerbate psychopathological symptoms in schizophrenic patients, but there is no evidence of similar effects in healthy subjects. " B 5003059 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCOS(=O)(=O)[O-] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause noncirrhotic portal hypertension due to hepatoportal sclerosis and nodular regenerative hyperplasia with long term therapy. Option B: It can induce morphological changes of phytoplankton Scenedesmus gutwinskii. Option C: It causes longstanding nicotinic receptor activation, resulting in spastic paralysis of susceptible nematodes (worms). Option D: It has a minimal side effect profile and uncomplicated metabolic profile, making it suitable for the treatment of mycotic outbreaks such as vaginal yeast infections and athlete's foot. " B 2733531 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@@H]3[C@@H]([C@H]([C@@](CO3)(C)O)NC)O)N)N)N)O)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause increased large intestinal motility and inhibition of large intestine fluid/electrolyte absorption. Option B: It blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells. Option C: It increases large intestinal motility and inhibits large intestine fluid/electrolyte absorption. Option D: It causes longstanding nicotinic receptor activation, resulting in spastic paralysis of susceptible nematodes (worms). " B 86290025 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC/C=C\\C/C=C\\CCOS(=O)(=O)[O-] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. Option B: It is known to exacerbate psychopathological symptoms in schizophrenic patients, but there is no evidence of similar effects in healthy subjects. Option C: It can induce morphological changes of phytoplankton Scenedesmus gutwinskii. Option D: It has shown similar efficacy to theophylline in the treatment of asthma, but with significantly fewer side effects in animal and human studies. " C 15134 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCCCNC(=O)C(Cl)Cl)CCCNC(=O)C(Cl)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking cortical and limbic arousal following stimulation of the reticular pathways. Option B: It inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis. Option C: It increases peripheral glucose utilization, decreases hepatic gluconeogenesis, and may increase the number and sensitivity of insulin receptors. Option D: It raises blood sugar through activation of hepatic receptors, stimulating glycogenolysis and the release of glucose. " B 157922 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)CCC(=O)CN Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It results in the generation of toxic singlet oxygen that destroys cell membranes and thereby kills the tumour cells. Option B: It inhibits DNA synthesis and causes cell death. Option C: It inhibits DNA synthesis and stops the growth of cancer cells. Option D: It inhibits feeding and induces dramatic weight loss in mice. " A 11588811 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCC1=CC(=CC=C1)NC(=O)[C@@H](COP(=O)(O)O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Option B: It can stimulate ASM contraction by activating M3 muscarinic receptors. Option C: It is a potent antagonist for both S1P1 and S1P3 receptors. Option D: It can exhibit effects mediated through cannabinoid receptors 1 and 2 (CB1 and CB2). " C 6505803 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\\C=C(\\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)/C)OC)OC(=O)N)\\C)C)O)OC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It induces cell death and growth arrest in Burkitt lymphoma cell lines at low concentrations. Option B: It induces cell cycle arrest and apoptosis in various cancer cells. Option C: It induces apoptosis and displays antitumour effects. Option D: It causes interstrand linkages in DNA resulting in cell apoptosis. " C 3011155 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=NC(=NC2=C1N=CN2[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It inhibits feeding and induces dramatic weight loss in mice. Option B: It inhibits root development and growth. Option C: It inhibits DNA synthesis and stops the growth of cancer cells. Option D: It inhibits DNA synthesis and causes cell death. " D 4921 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN(CCC)C(=O)C(CCC(=O)OCCCN1CCN(CC1)CCOC(=O)CC2=C(N(C3=C2C=C(C=C3)OC)C(=O)C4=CC=C(C=C4)Cl)C)NC(=O)C5=CC=CC=C5 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause noncirrhotic portal hypertension due to hepatoportal sclerosis and nodular regenerative hyperplasia with long term therapy. Option B: It is metabolized to indometacin and proglumide, a drug with antisecretory effects that helps prevent injury to the stomach lining. Option C: It can cause transient serum enzyme elevations during therapy, rare cases of cholestatic hepatitis, instances of nodular regenerative hyperplasia, and sinusoidal obstruction syndrome when given in high doses. Option D: It is metabolised to indometacin and proglumide, a drug with antisecretory effects that helps prevent injury to the stomach lining. " D 9500 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=NC=C1C(=O)N)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is associated with transient and usually mild elevations in serum aminotransferase during therapy and to rare instances of self-limited, clinically apparent idiosyncratic acute liver injury as well as to cases of reactivation of hepatitis B in susceptible individuals. Option B: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option C: It interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, such as cisplatin, in killing cancer cells. Option D: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. " C 60490 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C1=CC2=CC=CC=C2S1)N(C(=O)N)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4. Option B: It increases breakdown of LDL cholesterol by inducing hepatic LDL receptors. Option C: It decreases hepatic cholesterol levels, increases hepatic uptake of cholesterol, and reduces plasma cholesterol levels. Option D: It increases peripheral glucose utilization, decreases hepatic gluconeogenesis, and may increase the number and sensitivity of insulin receptors. " A 11742055 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C(=O)C1=C2C(=C3C(=C1O)C(=CC(=O)O3)C4=CC=CC=C4)C=C(O2)C(C)(C)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits cytotoxicity against cancer cell lines HCT-116 and MKN-45. Option B: It can potentiate the neutralizing action of ATIII on activated Factor X 300-fold. Option C: It can exhibit high selectivity to FLT3 preventing the c-Kit-driven myelosuppression observed in other therapies. Option D: It exhibits cytotoxicity against the A2780 ovarian cancer cell line. " D 70697841 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC1=C2C(=CC(=C1)C(=O)O)[C@@H]([C@H](O2)C(C)(C)O)O)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can potentiate the neutralizing action of ATIII on activated Factor X 300-fold. Option B: It exhibits cytotoxicity against cancer cell lines HCT-116 and MKN-45. Option C: It can exhibit high selectivity to FLT3 preventing the c-Kit-driven myelosuppression observed in other therapies. Option D: It exhibits cytotoxicity against the A2780 ovarian cancer cell line. " B 24757901 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)O[C@H]1[C@@H]2[C@]([C@H](CCC2(C)C)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)([C@H]4C(=O)C[C@](O[C@@]4([C@H]1O)C)(C)C=C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause transient serum enzyme elevations during therapy, rare cases of cholestatic hepatitis, instances of nodular regenerative hyperplasia, and sinusoidal obstruction syndrome when given in high doses. Option B: It can cause noncirrhotic portal hypertension due to hepatoportal sclerosis and nodular regenerative hyperplasia with long term therapy. Option C: It causes longstanding nicotinic receptor activation, resulting in spastic paralysis of susceptible nematodes (worms). Option D: It shows relaxative effects on isolated guinea pig tracheal spirals in vitro. " D 26964 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C(=C1CNNC(=O)C(CO)N)O)O)O.Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Option B: It can have effects on the liver and central nervous system from oral exposure in animal studies. Option C: It causes central nervous system depression and irritation of the eyes and mucous membranes upon acute exposure in humans. Option D: Acute exposure to this molecule affects the blood with clinical signs of central nervous system depression. " A 2327 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C(=C1CNNC(=O)C(CO)N)O)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: Acute inhalation exposure to it can cause irritation of the respiratory tract and eye irritation in humans. Option B: It causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Option C: Acute exposure to this molecule affects the blood with clinical signs of central nervous system depression. Option D: It causes central nervous system depression and irritation of the eyes and mucous membranes upon acute exposure in humans. " B 5280443 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is associated with transient serum enzyme elevations during therapy and with rare instances of acute liver injury. Option B: It can be associated with mild serum enzyme elevations and has been linked to rare instances of clinically apparent liver injury. Option C: It induces autophagy in leukaemia cells. Option D: It is associated with a risk of producing hyperkalemia. " C 5282193 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN(C(=O)C(NC(=O)C1=CC=CC=C1)CCC(=O)OCCCN2CCN(CC2)CCOC(=O)CC3=C(N(C4=C3C=C(C=C4)OC)C(=O)C5=CC=C(C=C5)Cl)C)CCC.C(=C\\C(=O)O)\\C(=O)O.C(=C\\C(=O)O)\\C(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is metabolised to indometacin and proglumide, a drug with antisecretory effects that helps prevent injury to the stomach lining. Option B: It can cause noncirrhotic portal hypertension due to hepatoportal sclerosis and nodular regenerative hyperplasia with long term therapy. Option C: It is metabolized to indometacin and proglumide, a drug with antisecretory effects that helps prevent injury to the stomach lining. Option D: It can cause transient serum enzyme elevations during therapy, rare cases of cholestatic hepatitis, instances of nodular regenerative hyperplasia, and sinusoidal obstruction syndrome when given in high doses. " C 24795562 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)O[C@@H]1C[C@@]2([C@H](C(=O)C[C@](O2)(C)C=C)[C@@]3([C@@H]1C(CC[C@@H]3O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)(C)C)C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It increases large intestinal motility and inhibits large intestine fluid/electrolyte absorption. Option B: It shows relaxative effects on isolated guinea pig tracheal spirals in vitro. Option C: It may cause gastritis, rhinitis, pharyngitis, laryngitis, and tracheobronchitis upon acute inhalation exposure. Option D: It causes longstanding nicotinic receptor activation, resulting in spastic paralysis of susceptible nematodes (worms). " B 6433141 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCCSC1=CC=CC=C1NC(=O)/C=C/C2=CC=CC=C2.Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It lowers blood pressure through arteriolar vasodilation. Option B: It can cause arteriolar vasodilation. Option C: It exhibits arteriolar vasodilation. Option D: It reduces virus replication in vitro. " D 24795561 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)O[C@H]1[C@@H]2[C@]([C@H](CCC2(C)C)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)([C@H]4C(=O)C[C@](O[C@@]4([C@H]1OC(=O)C)C)(C)C=C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause noncirrhotic portal hypertension due to hepatoportal sclerosis and nodular regenerative hyperplasia with long term therapy. Option B: It shows relaxative effects on isolated guinea pig tracheal spirals in vitro. Option C: It increases large intestinal motility and inhibits large intestine fluid/electrolyte absorption. Option D: It causes longstanding nicotinic receptor activation, resulting in spastic paralysis of susceptible nematodes (worms). " B 6423 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([N+](=O)[O-])(Cl)(Cl)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is a severe irritant, causing immediate, severe inflammation of the eyes, nose, and throat, and significant injuries to the upper and lower respiratory tract. Option B: It causes mild central nervous system effects, including dizziness, giddiness, slight nausea, and headache. Option C: It causes respiratory effects such as respiratory irritation, wheezing, asthma, pneumonia, and fibrosis with chronic (long-term) inhalation exposure. Option D: It can cause irritation of the eyes, cough, wheezing, asthmatic symptoms, pulmonary edema, pneumonia, dizziness, weakness, headache, and chest pains. " A 2576 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(C)(COC(=O)N)COC(=O)NC(C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It interrupts neuronal communication within the reticular formation and spinal cord, resulting in sedation and alteration in pain perception. Option B: It potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking cortical and limbic arousal following stimulation of the reticular pathways. Option C: It can potentiate the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways. Option D: It increases secretion by the exocrine glands, and produces contraction of the iris sphincter muscle and ciliary muscle (when given topically to the eyes) by mainly stimulating muscarinic receptors. " A 135499520 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC2=C(N1[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)O)N=C(NC2=O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It inhibits root development and growth. Option B: It inhibits DNA synthesis and causes cell death. Option C: It inhibits feeding and induces dramatic weight loss in mice. Option D: It inhibits DNA synthesis and stops the growth of cancer cells. " B 119182 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC2=C(N=C(N=C2N1[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)F)Cl)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It inhibits root development and growth. Option B: It inhibits DNA synthesis and stops the growth of cancer cells. Option C: It inhibits DNA synthesis and causes cell death. Option D: It inhibits feeding and induces dramatic weight loss in mice. " B 108079 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC1(NC(=O)CC[C@@H](C(=O)O)N)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause increased large intestinal motility and inhibition of large intestine fluid/electrolyte absorption. Option B: It causes an unpleasant hypersensitivity to alcohol (the 'disulfiram effect') and inhibits aldehyde dehydrogenase (NAD(+)). Option C: It is associated with moderate hyperhomocysteinemia, especially in the context of marginal folate intake, due to a polymorphism of methylenetetrahydrofolate reductase (C677T). Option D: It increases large intestinal motility and inhibits large intestine fluid/electrolyte absorption. " B 135411 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C2CC3CC1CC(C2)(C3)C4=C(C=CC(=C4)C5=CC6=C(C=C5)C=C(C=C6)C(=O)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It induces apoptosis and displays antitumour effects. Option B: It induces cell death and growth arrest in Burkitt lymphoma cell lines at low concentrations. Option C: It causes interstrand linkages in DNA resulting in cell apoptosis. Option D: It induces cell cycle arrest and apoptosis in various cancer cells. " D 52947716 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@@H]\\1CC[C@H]2[C@H]([C@H]([C@@H]([C@]3(O2)CC[C@@H]([C@@H](O3)C[C@@H](C)O)C)C)OC(=O)/C=C/[C@@H]([C@H]([C@@H](C(=O)[C@@H]([C@H]([C@@H](C(=O)[C@]([C@H]([C@@H](C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, such as cisplatin, in killing cancer cells. Option B: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option C: It induces apoptosis in a variety of cell types and exhibits antifungal, antitumour, and nematicidal activities. Option D: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. " C 20966 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1CC2=C(C(=C(C=C2)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)O)C(=O)O1 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and blockage of the receptors at high levels, leading to paralysis and death. Option B: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option C: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option D: It has cytotoxic effects on kidney and liver cells in vitro but only minor effects in vivo, due to its rapid metabolism and excretion. " D 54675783 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can decrease coagulation factor activity to realize its physiologic effect. Option B: It can increase coagulation factor VIII activity and concentration to realize its physiologic effect. Option C: It can decrease cell membrane integrity to realize its physiologic effect. Option D: It can decrease prothrombin activity to realize its physiologic effect. " D 10836 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](CC1=CC=CC=C1)NC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option B: It can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. Option C: It impairs energy-requiring processes, such as recovery from potentially lethal damage induced by radiation treatment and some cytotoxic drugs. Option D: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. " B 6057 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C[C@@H](C(=O)O)N)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause increased amount of this molecule in the blood of premature infants, which is marked by decreased motor activity, lethargy and poor feeding. Option B: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and blockage of the receptors at high levels, leading to paralysis and death. Option C: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option D: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. " A 5311065 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C[C@H](N(C1)C(=O)[C@@H]2CSSCCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(=O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can increase coagulation factor VIII activity and concentration to realize its physiologic effect. Option B: It can decrease blood pressure to realize its physiologic effect. Option C: It can decrease coagulation factor activity to realize its physiologic effect. Option D: It can decrease prothrombin activity to realize its physiologic effect. " A 135398739 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C[C@@H](O[C@@H]1CO)N2C=NC3=C2N=CNC3=O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause transient serum enzyme elevations during therapy, rare cases of cholestatic hepatitis, instances of nodular regenerative hyperplasia, and sinusoidal obstruction syndrome when given in high doses. Option B: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option C: It is associated with transient and usually mild elevations in serum aminotransferase during therapy and to rare instances of self-limited, clinically apparent idiosyncratic acute liver injury as well as to cases of reactivation of hepatitis B in susceptible individuals. Option D: It can cause noncirrhotic portal hypertension due to hepatoportal sclerosis and nodular regenerative hyperplasia with long term therapy. " D 280 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)=O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can produce a sour taste in the mouth and a stinging sensation in the nose and throat when inhaled at concentrations much higher than usual atmospheric levels. Option B: Its antianginal effects were identified after it produced headaches in factory workers and relief from chest pain in workers with angina pectoris or heart failure. Option C: It causes respiratory effects such as respiratory irritation, wheezing, asthma, pneumonia, and fibrosis with chronic (long-term) inhalation exposure. Option D: It is a severe irritant, causing immediate, severe inflammation of the eyes, nose, and throat, and significant injuries to the upper and lower respiratory tract. " A 123831 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C(=NCCC[C@@H](C(=O)O)N)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can interfere with L-arginine in the production of nitric oxide, a key chemical to endothelial and hence cardiovascular health. Option B: By inhibiting the endogenous production of cholesterol within the liver, it lowers abnormal cholesterol and lipid levels and ultimately reduces the risk of cardiovascular disease. Option C: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and blockage of the receptors at high levels, leading to paralysis and death. Option D: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and receptor blockage at high levels, leading to paralysis and death. " A 5819 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)C[C@@H](C(=O)O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: Acute exposure to this molecule affects the blood with clinical signs of central nervous system depression. Option B: It can have a particularly strong effect on the cardiac system, although it acts on nearly every cell of the body. Option C: It can have effects on the liver and central nervous system from oral exposure in animal studies. Option D: It causes central nervous system depression and irritation of the eyes and mucous membranes upon acute exposure in humans. " B 3035 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C(=C(Cl)Cl)C2=CC=C(C=C2)Cl)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is associated with transient serum aminotransferase elevations during therapy and with rare instances of clinically apparent liver injury. Option B: It can be associated with mild serum enzyme elevations and has been linked to rare instances of clinically apparent liver injury. Option C: It can increase activity of liver enzymes in workers exposed to DDT and other pesticides. Option D: It is associated with transient serum enzyme elevations during therapy and with rare instances of acute liver injury. " C 12699 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C(=O)N)N=O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause respiratory effects in humans following acute (short-term) and chronic (long-term) inhalation exposures. Option B: It has liver, kidney, spleen, and central nervous system (CNS) effects in chronic (long-term) animal studies. Option C: It causes respiratory effects such as respiratory irritation, wheezing, asthma, pneumonia, and fibrosis with chronic (long-term) inhalation exposure. Option D: It can cause dermatitis in humans with acute (short-term) exposure. " D 3005573 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCOC1=CC=C(C=C1)/C(=C(/CCCl)\\C2=CC=CC=C2)/C3=CC=CC=C3 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option B: It has been associated with development of fatty liver, steatohepatitis, cirrhosis, and rare instances of clinically apparent acute liver injury with long term therapy. Option C: It can cause noncirrhotic portal hypertension due to hepatoportal sclerosis and nodular regenerative hyperplasia with long term therapy. Option D: It can cause transient serum enzyme elevations during therapy, rare cases of cholestatic hepatitis, instances of nodular regenerative hyperplasia, and sinusoidal obstruction syndrome when given in high doses. " B 2520 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes significant discomfort throughout the day and requires frequent treatment with eye drops. Option B: It can cause unexplained hypotension and conduction abnormalities in overdose situations. Option C: It can cause dermatitis in humans with acute (short-term) exposure. Option D: It causes overexcitation, paralysis, and death in insects. " B 2478 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CS(=O)(=O)OCCCCOS(=O)(=O)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause transient serum enzyme elevations during therapy, rare cases of cholestatic hepatitis, instances of nodular regenerative hyperplasia, and sinusoidal obstruction syndrome when given in high doses. Option B: It can cause noncirrhotic portal hypertension due to hepatoportal sclerosis and nodular regenerative hyperplasia with long term therapy. Option C: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option D: It has been associated with development of fatty liver, steatohepatitis, cirrhosis, and rare instances of clinically apparent acute liver injury with long term therapy. " A 2477 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option B: It inhibits the expression of involucrin (hINV), a marker of keratinocyte differentiation, via a protein kinase Cdelta (PKCdelta), Ras, MEKK1, MEK3 cascade that increases AP1 factor level and AP1 factor binding to DNA elements in the hINV promoter. Option C: It can bind to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus, thus inhibiting the firing rate of 5-HT-containing neurons in the dorsal raphe. Option D: It blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors, depresses the release of hypothalamic and hypophyseal hormones, and affects basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. " C 6328 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CI Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause respiratory effects in humans following acute (short-term) and chronic (long-term) inhalation exposures. Option B: It can lead to pulmonary edema with massive acute inhalation exposure. Option C: It can cause dermatitis in humans with acute (short-term) exposure. Option D: It causes severe respiratory tract irritation and inflammation in humans upon acute inhalation exposure. " B 8771 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(CC)CCC(CC(C)C)OS(=O)(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option B: It can cause noncirrhotic portal hypertension due to hepatoportal sclerosis and nodular regenerative hyperplasia with long term therapy. Option C: It can cause transient serum enzyme elevations during therapy, rare cases of cholestatic hepatitis, instances of nodular regenerative hyperplasia, and sinusoidal obstruction syndrome when given in high doses. Option D: It can cause episodes of epidermal necrosis without significant long-term effects and post-sclerosis pigmentation that resolved within a few months. " D 6569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits slight neurological, liver, kidney, and respiratory effects. Option B: It can affect the lungs, gastrointestinal system, blood, liver, kidneys, central nervous system, and eyes. Option C: It has liver, kidney, immunological, endocrine, and developmental effects reported in humans. Option D: It can affect the lungs, liver, kidneys, and heart. " A 6278 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(Cl)(Cl)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It appears as a high explosive. Option B: It may have a narcotic effect in high concentrations. Option C: It interferes with an enzyme pathway. Option D: It exhibits general anesthesia. " B 2733 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC2=C(C=C1Cl)NC(=O)O2 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits decreased sympathetic activity as its physiologic effect. Option B: It causes centrally-mediated muscle relaxation. Option C: It exhibits centrally-mediated muscle relaxation. Option D: It can exhibit centrally-mediated muscle relaxation as its physiologic effect. " C 6464 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C1(C(=O)NC(=O)NC1=O)CC=C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is known to exacerbate psychopathological symptoms in schizophrenic patients, but there is no evidence of similar effects in healthy subjects. Option B: It demonstrates sedative, hypnotic, and anticonvulsant effects. Option C: It has shown similar efficacy to theophylline in the treatment of asthma, but with significantly fewer side effects in animal and human studies. Option D: It does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. " B 1548887 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC\\1=C(C2=C(/C1=C\\C3=CC=C(C=C3)S(=O)C)C=CC(=C2)F)CC(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option B: It inhibits lateral shoot branching, stimulates germination of Striga, and aids in the symbiosis of over 80% of terrestrial plants with fungi at arbuscular mycorrihizae in roots. Option C: It may be associated with fewer gastrointestinal side effects than other NSAIDs, except for the cyclooxygenase-2 (COX-2) inhibitor drug class. Option D: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. " C 4543 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. Option B: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option C: It down-regulates cerebral cortical β-adrenergic receptors and sensitizes post-synaptic serotonergic receptors with chronic use. Option D: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. " C 2256 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC1=NC(=NC(=N1)Cl)NC(C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option B: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option C: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option D: It causes male tadpoles to turn into hermaphrodites - frogs with both male and female sexual characteristics. " D 4760 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2C(=O)C3=CC=CC=C3C2=O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is a preferential COX-2 inhibitor, purportedly reducing the risk of adverse gastrointestinal tract effects. Option B: It has a higher incidence of severe adverse effects compared to warfarin. Option C: It demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. Option D: It has a lower incidence of metabolic adverse effects compared to other medications in the same class. " B 5280723 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1CCCCCCC(=O)O)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option B: It causes vasodilation and prevents or reverses the functional closure of the ductus arteriosus (DA) shortly after birth. Option C: It causes respiratory effects such as respiratory irritation, wheezing, asthma, pneumonia, and fibrosis with chronic (long-term) inhalation exposure. Option D: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. " B 5707 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=CC=C1)C)NC2=NCCCS2 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has side effects that are a cause for concern. Option B: It has minimal side effects, with the most common being headache and fatigue. Option C: It has few side effects and is reported to be safe and effective. Option D: It has a very high potency and a comparable side effect profile to the parent compound. " A 135398747 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+]1=CC=CC=C1/C=N/O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It increases acetylcholine activity. Option B: It inhibits acetylcholinesterase, resulting in neurotoxic effects. Option C: It initially results in reversible inactivation of acetylcholinesterase. Option D: It induces the effect of inhibiting the enzyme acetylcholinesterase in peripheral nerve endings. " C 54960 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC(=NC(=N1)NC(=O)NS(=O)(=O)CC2=CC=CC=C2C(=O)OC)OC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It inhibits root development and growth. Option B: It causes significant discomfort throughout the day and requires frequent treatment with eye drops. Option C: It decreases chlorophyll content and inhibits plant growth. Option D: It inhibits feeding and induces dramatic weight loss in mice. " C 9898279 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)O)C)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)O)O)O)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It indirectly increases testosterone production in male rats through the stimulation of luteinizing hormone. Option B: It has been associated with fever, mild jaundice and clinically apparent liver injury in up to 2% of treated patients. Option C: It has reproductive effects in women exposed by inhalation to high levels and adverse effects on the developing fetus in animal tests. Option D: It causes severe respiratory tract irritation and inflammation in humans upon acute inhalation exposure. " A 464 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(=O)NCC(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can lower blood pressure and reduce the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. Option B: It causes debilitating symptoms, significant functional limitations, and a reduced quality of life in patients with tenosynovial giant cell tumors. Option C: It can lead to renal damage, chronic kidney disease, and cardiovascular disease. Option D: It can cause elevated blood levels of ammonia, leading to neurologic problems, cerebral edema, coma, and death in a rare genetic disorder. " C 3120 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C(=O)NC1=CC(=C(C=C1)Cl)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It interferes with an enzyme pathway. Option B: It can induce general anesthesia. Option C: It works by inhibiting photosynthesis. Option D: It blocks the plastoquinone binding site of photosystem II, disallowing electron flow. " D 11443 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)N=C=O)N=C=O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes significant discomfort throughout the day and requires frequent treatment with eye drops. Option B: It causes over-pressurization in an enclosed space and is toxic and carcinogenic. Option C: It inhibits feeding and induces dramatic weight loss in mice. Option D: It causes overexcitation, paralysis, and death in insects. " B 2554 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2C(=O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can exhibit a decreased central nervous system disorganized electrical activity. Option B: It exhibits decreased central nervous system disorganized electrical activity. Option C: It exhibits a decreased central nervous system disorganized electrical activity. Option D: It decreases central nervous system disorganized electrical activity. " B 6322 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C[C@@H](C(=O)O)N)CN=C(N)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: Acute inhalation exposure to it can cause irritation of the respiratory tract and eye irritation in humans. Option B: It stimulates the release of growth hormone and prolactin in large doses. Option C: It causes central nervous system depression and irritation of the eyes and mucous membranes upon acute exposure in humans. Option D: It causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. " B 135398658 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)NC(=N3)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes a deficiency of coenzymes and a buildup of toxic substances responsible for numerous adverse side effects. Option B: It has a higher incidence of severe adverse effects compared to warfarin. Option C: It results in a buildup of toxic substances that are responsible for numerous adverse side effects. Option D: It has a lower incidence of metabolic adverse effects compared to other medications in the same class. " C 9941444 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@H](CN2[C@@H]1C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C2=O)CC3=CC=CC=C3)CC4=CC=C(C=C4)OCC5=CC=CC=C5)CCCCN)CC6=CNC7=CC=CC=C76)C8=CC=CC=C8)OC(=O)NCCN Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option B: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option C: It can cause transient serum enzyme elevations during therapy, rare cases of cholestatic hepatitis, instances of nodular regenerative hyperplasia, and sinusoidal obstruction syndrome when given in high doses. Option D: It has many side effects including suppression of gall bladder contractility and bile production, and maintenance therapy can cause cholelithiasis and accompanying elevations in serum enzymes and bilirubin. " D 9868491 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)OC(=O)CCC/C=C\\C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/C(COC2=CC=CC=C2)(F)F)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It inhibits prostaglandin synthesis. Option B: It decreases prostaglandin production. Option C: It can increase prostaglandin activity to realize its physiologic effect. Option D: It decreases prostaglandin production and platelet aggregation. " C 700 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CO)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause increased cellular permeability causing leakage of cellular contents. Option B: It has low osmolarity and is associated with fewer side effects. Option C: It inhibits ergosterol synthesis, resulting in increased cellular permeability. Option D: It has vascular sclerosing activity. " D 785 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has side effects that are a cause for concern. Option B: It has a broad spectrum of action, being systemic with protective and curative action. Option C: It has depigmenting activity. Option D: It has long-lasting effects and can be administered once a day. " C 2733526 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC/C(=C(\\C1=CC=CC=C1)/C2=CC=C(C=C2)OCCN(C)C)/C3=CC=CC=C3 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can result in a decrease in heart rate and vascular resistance. Option B: It exhibits decreased platelet production as its physiologic effect. Option C: It exhibits decreased blood pressure as its physiologic effect. Option D: It results in a blockage or change in the expression of estrogen dependent genes. " D 84088 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CC(=O)OCC(=O)[C@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)O)C)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has liver, kidney, spleen, and central nervous system (CNS) effects in chronic (long-term) animal studies. Option B: It affects the respiratory, cardiovascular, gastrointestinal, and central nervous system (CNS) of chronically exposed workers. Option C: It has liver, kidney, immunological, endocrine, and developmental effects reported in humans. Option D: It triggers a variety of important cardiovascular, metabolic, immunologic and homeostatic effects by binding with the cortisol receptor. " D 5910 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@H]1[C@H](COC1=O)CC2=CN=CN2C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It inhibits lateral shoot branching, stimulates germination of Striga, and aids in the symbiosis of over 80% of terrestrial plants with fungi at arbuscular mycorrihizae in roots. Option B: It can potentiate the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways. Option C: It increases secretion by the exocrine glands, and produces contraction of the iris sphincter muscle and ciliary muscle (when given topically to the eyes) by mainly stimulating muscarinic receptors. Option D: It potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking cortical and limbic arousal following stimulation of the reticular pathways. " C 41867 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It inhibits DNA synthesis and stops the growth of cancer cells. Option B: It can interfere with DNA replication and transcription by inhibiting DNA helicase activity. Option C: It inhibits DNA synthesis and causes cell death. Option D: It decreases DNA replication, protein synthesis, and RNA replication. " B 157355 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O[C@H]([C@@H](CO)O)[C@@H]([C@H](CO)O)O)O)O)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It increases large intestinal motility and inhibits large intestine fluid/electrolyte absorption. Option B: It can cause increased large intestinal motility and inhibition of large intestine fluid/electrolyte absorption. Option C: It can cause transient serum enzyme elevations during therapy, rare cases of cholestatic hepatitis, instances of nodular regenerative hyperplasia, and sinusoidal obstruction syndrome when given in high doses. Option D: It can stimulate small intestine fluid/electrolyte secretion. " D 9294 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]([C@@H](C1=CC=CC=C1)O)NC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can increase norepinephrine activity. Option B: It causes no greater fecal gastrointestinal blood loss than placebo, in contrast to aspirin. Option C: It can increase norepinephrine and dopamine efflux throughout the brain, impair cognition, and have locomotor-activating effects. Option D: It has longer acting adrenergic effects compared to norepinephrine. " A 15553 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=NC(=C1Cl)C(=O)O)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It does not cause drowsiness because it does not readily enter the central nervous system. Option B: It does not affect members of the family Poaceae (grasses). Option C: It does not cause drowsiness or anticholinergic side effects. Option D: It does not normally result in systemic adverse effects. " B 154101 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)[C@@H]([C@H]1CCCCN1)C2=CC=CC=C2 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits central nervous system depression. Option B: It can stimulate the central nervous system. Option C: It stimulates the central nervous system. Option D: It exhibits central nervous system stimulation as its physiologic effect. " B 5452 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option B: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option C: It has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazine. Option D: It has shown similar efficacy to theophylline in the treatment of asthma, but with significantly fewer side effects in animal and human studies. " C 92786 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(CC[C@H](C4)O)C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has reproductive effects in women exposed by inhalation to high levels and adverse effects on the developing fetus in animal tests. Option B: It has the ability to cause serious adverse effects, including agranulocytosis. Option C: It has shown similar efficacy to theophylline in the treatment of asthma, but with significantly fewer side effects in animal and human studies. Option D: It can have profound negative effects on the maternal-infant bond and later infant development. " D 5283344 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC(/C=C/C=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors, depresses the release of hypothalamic and hypophyseal hormones, and affects basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. Option B: It can lead to lower steady-state levels of HNE, and these cells acquire resistance to apoptosis induced by lipid peroxidation-causing agents such as H(2)O(2), UVA, superoxide anion, and pro-oxidant xenobiotics. Option C: It inhibits lateral shoot branching, stimulates germination of Striga, and aids in the symbiosis of over 80% of terrestrial plants with fungi at arbuscular mycorrihizae in roots. Option D: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. " B 5481173 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C(=O)O)O/N=C(/C1=CSC(=N1)N)\\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C[N+]4=CC=CC=C4)C(=O)[O-] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It affects skin, female fertility, fat depots, pancreatic integrity, and regenerative growth. Option B: It causes debilitating symptoms, significant functional limitations, and a reduced quality of life in patients with tenosynovial giant cell tumors. Option C: It aids maintenance of gut barrier function, intestinal cell proliferation and differentiation, and reduces septic morbidity and the symptoms of Irritable Bowel Syndrome. Option D: It can result in impaired cell wall homeostasis, loss of cell integrity, and ultimately bacterial cell death. " D 10964 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C=O)C=O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option B: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option C: It can have effects of ionizing and non-ionizing radiation, air pollution and natural toxic gases such as ozone, and chemicals and toxins including oxidizing disinfectants. Option D: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. " C 4095 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can mimic the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain transmission. Option B: It is associated with transient and usually mild elevations in serum aminotransferase during therapy and to rare instances of self-limited, clinically apparent idiosyncratic acute liver injury as well as to cases of reactivation of hepatitis B in susceptible individuals. Option C: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option D: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. " A 9550 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=[N+]=[N-] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is associated with numerous side effects including dizziness, drowsiness, nausea, vomiting, diarrhea, headache, aphasia, lack of concentration, psychomotor retardation, speech disturbances, ataxia, depression, and hyponatremia. Option B: It can cause irritation of the eyes, cough, wheezing, asthmatic symptoms, pulmonary edema, pneumonia, dizziness, weakness, headache, and chest pains. Option C: It can cause mental retardation, macrocephaly with cerebral atrophy, hypotonia, seizures, and involuntary movements in patients who have excess accumulation of D-2-hydroxyglutaric acid in the urine. Option D: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. " B 6658 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=C)C(=O)OC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes severe respiratory tract irritation and inflammation in humans upon acute inhalation exposure. Option B: It can cause respiratory effects in humans following acute (short-term) and chronic (long-term) inhalation exposures. Option C: It causes central nervous system depression and irritation of the eyes and mucous membranes upon acute exposure in humans. Option D: It can cause dermatitis in humans with acute (short-term) exposure. " B 447715 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@@H]1[C@@H]2C[C@@H](CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3[C@@H]1O)CC[C@@H]4[C@H](C)CCC(=O)O)C)C)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is associated with transient serum aminotransferase elevations during therapy and with rare instances of clinically apparent liver injury. Option B: It is associated with transient serum enzyme elevations during therapy and with rare instances of acute liver injury. Option C: It can lead to hepatic injury often resulting in end-stage liver failure that requires liver transplantation. Option D: It has a low rate of transient serum aminotransferase elevations during therapy and rare instances of clinically apparent liver injury. " C 6274 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(NC=N1)C[C@@H](C(=O)O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause irritation of the eyes, cough, wheezing, asthmatic symptoms, pulmonary edema, pneumonia, dizziness, weakness, headache, and chest pains. Option B: It can cause mental retardation, macrocephaly with cerebral atrophy, hypotonia, seizures, and involuntary movements in patients who have excess accumulation of D-2-hydroxyglutaric acid in the urine. Option C: It is accompanied by a wide range of symptoms, from mental and physical retardation to poor intellectual functioning, emotional instability, tremor, ataxia, and psychosis. Option D: It is associated with numerous side effects including dizziness, drowsiness, nausea, vomiting, diarrhea, headache, aphasia, lack of concentration, psychomotor retardation, speech disturbances, ataxia, depression, and hyponatremia. " C 2833 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It increases secretion by the exocrine glands, and produces contraction of the iris sphincter muscle and ciliary muscle (when given topically to the eyes) by mainly stimulating muscarinic receptors. Option B: It inhibits lateral shoot branching, stimulates germination of Striga, and aids in the symbiosis of over 80% of terrestrial plants with fungi at arbuscular mycorrihizae in roots. Option C: It potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking cortical and limbic arousal following stimulation of the reticular pathways. Option D: It can decrease leukocyte chemotaxis and phagocytosis and inhibit the formation and release of a chemotactic glycoprotein that is produced during phagocytosis of urate crystals. " D 6137 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CSCC[C@@H](C(=O)O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option B: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option C: It causes debilitating symptoms, significant functional limitations, and a reduced quality of life in patients with tenosynovial giant cell tumors. Option D: It is known to exacerbate psychopathological symptoms in schizophrenic patients, but there is no evidence of similar effects in healthy subjects. " D 12594 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CC=C4[C@@]3(CC[C@@H](C4)OS(=O)(=O)O)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has anti-aging effects and is inversely associated with the development of atherosclerosis. Option B: It impairs energy-requiring processes, such as recovery from potentially lethal damage induced by radiation treatment and some cytotoxic drugs. Option C: It has therapeutic effects similar to salicylates, but lacks anti-inflammatory, antiplatelet, and gastric ulcerative effects. Option D: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. " A 10413 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(=O)O)CO Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can stimulate the central nervous system. Option B: It exhibits central nervous system stimulation. Option C: It exhibits central nervous system depression. Option D: It exhibits central nervous system depression and decreased central nervous system organized electrical activity. " D 4794 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CP(=O)(CCC(C(=O)O)N)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes a buildup of ammonia and a cessation of photosynthesis due to lack of glutamine. Option B: It can lead to the accumulation of itself and glycine in the brain when its plasma concentrations increase. Option C: It may inhibit the action of pepsin by subsequent increases in pH. Option D: It inhibits DNA synthesis and stops the growth of cancer cells. " A 8058 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option B: It causes respiratory effects such as respiratory irritation, wheezing, asthma, pneumonia, and fibrosis with chronic (long-term) inhalation exposure. Option C: It causes mild central nervous system effects, including dizziness, giddiness, slight nausea, and headache. Option D: It can cause irritation of the eyes, cough, wheezing, asthmatic symptoms, pulmonary edema, pneumonia, dizziness, weakness, headache, and chest pains. " C 1045 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCN)CN Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It affects skin, female fertility, fat depots, pancreatic integrity, and regenerative growth. Option B: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option C: It produces anti-androgenic effects in animals by reducing testosterone production and, at very high levels, reducing estrogen production, possibly by inhibiting testicular and ovarian steroidogenesis. Option D: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. " A 446157 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C1=NC(=NC(=C1/C=C/[C@H](C[C@H](CC(=O)O)O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has good tolerance, lack of toxicity, and no dose-limiting side effects. Option B: It can cause a 20%-22% relative reduction in major cardiovascular events for every 1 mmol/L reduction in LDL without any significant side effects or risks. Option C: It causes a reduction in major cardiovascular events without significant side effects or risks. Option D: It is irritant but produces no acute systemic effects and has no demonstrable genotoxic potential. " C 135403648 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It prevents DNA synthesis and the formation of DHF and THF. Option B: It inhibits DNA synthesis and causes cell death. Option C: It inhibits DNA synthesis and has some cell cycle phase specificity. Option D: It inhibits DNA synthesis and stops the growth of cancer cells. " A 5358 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can induce vasodilation of arterioles and large coronary arteries by activating potassium channels. Option B: It causes vasoconstriction of dilated arteries. Option C: It causes longstanding nicotinic receptor activation, resulting in spastic paralysis of susceptible nematodes (worms). Option D: It increases large intestinal motility and inhibits large intestine fluid/electrolyte absorption. " B 3520 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=N)(N)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It initially results in reversible inactivation of acetylcholinesterase. Option B: It increases acetylcholine activity. Option C: It induces the effect of inhibiting the enzyme acetylcholinesterase in peripheral nerve endings. Option D: It can inhibit the hydrolysis of acetylcholine released from functioning cholinergic neurons. " B 5610 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CCN)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes no greater fecal gastrointestinal blood loss than placebo, in contrast to aspirin. Option B: It can cause an increase in systolic blood pressure of 30 mmHg or more. Option C: It causes a reduction in major cardiovascular events without significant side effects or risks. Option D: It can cause a 20%-22% relative reduction in major cardiovascular events for every 1 mmol/L reduction in LDL without any significant side effects or risks. " B 11354606 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@@H]2CC[C@H]3C(=C)C[C@@H](O3)CC[C@]45C[C@@H]6[C@H](O4)[C@H]7[C@@H](O6)[C@@H](O5)[C@@H]8[C@@H](O7)CC[C@@H](O8)CC(=O)C[C@H]9[C@H](C[C@H](C1=C)O2)O[C@@H]([C@@H]9OC)C[C@@H](CN)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has microtubule inhibition. Option B: It exhibits microtubule inhibition as its physiologic effect. Option C: It exhibits decreased mitosis and microtubule inhibition as its physiologic effects. Option D: It inhibits microtubules. " D 3325 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(N=C(S1)N=C(N)N)CSCCC(=NS(=O)(=O)N)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It inhibits gastric acid secretion. Option B: It can decrease motility of the gastrointestinal and urinary tracts and inhibit gastric acid secretion. Option C: It decreases prostaglandin production and platelet aggregation. Option D: It prevents the final step in gastric acid production. " A 54676537 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)CC(C1=CC=C(C=C1)[N+](=O)[O-])C2=C(C3=CC=CC=C3OC2=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can effectively and safely increase lumbar and hip bone mineral density in osteoporotic patients who also received vitamin D3 supplementation. Option B: It inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). Option C: It can inhibit vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). Option D: It prevents carboxylation of vitamin K-dependent clotting factors and interferes with coagulation. " D 674 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: Long-term inhalation of low concentrations or short-term inhalation of low concentrations has adverse health effects. Option B: It can cause respiratory effects in humans following acute (short-term) and chronic (long-term) inhalation exposures. Option C: It causes severe respiratory tract irritation and inflammation in humans upon acute inhalation exposure. Option D: It can cause dermatitis in humans with acute (short-term) exposure. " A 667490 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC2=C(N1)C(=S)N=CN2 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is associated with a high rate of serum aminotransferase elevations, which can be accompanied by jaundice. Option B: It is associated with transient serum aminotransferase elevations during therapy and with rare instances of clinically apparent liver injury. Option C: It can be associated with mild serum enzyme elevations and has been linked to rare instances of clinically apparent liver injury. Option D: It has a low rate of transient serum aminotransferase elevations during therapy and rare instances of clinically apparent liver injury. " A 5962 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCN)C[C@@H](C(=O)O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is toxic to both prokaryotic and eukaryotic cells, resulting in significant cell death at appropriate doses. Option B: It is associated with transient serum enzyme elevations during therapy and with rare instances of acute liver injury. Option C: It can be improved by high doses of vitamin C. Option D: It stimulates the release of growth hormone and prolactin in large doses. " C 5732 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)C2=C(N3C=C(C=CC3=N2)C)CC(=O)N(C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits central nervous system stimulation. Option B: It exhibits central nervous system depression. Option C: It stimulates the central nervous system. Option D: It can stimulate the central nervous system. " B 6579 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC(=O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits hypotensive and neuroprotective effects. Option B: It has similar biological activity as antivirals and neuroprotective effects. Option C: It causes harmful health effects and bioaccumulates. Option D: It has neurotoxic effects. " D 6918141 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](CCCC(C)(C)O)[C@H]1CC[C@@H]\\2[C@@]1(CCC/C2=C\\C=C/3\\C[C@H]([C@H]([C@@H](C3=C)O)OCCCO)O)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can effectively and safely increase lumbar and hip bone mineral density in osteoporotic patients who also received vitamin D3 supplementation. Option B: It decreases serum calcium by inhibiting tumor-induced bone resorption and reducing calcium flow from the resorbing bone into the blood in malignancy-related hypercalcemia. Option C: It prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction by inhibiting the influx of calcium in smooth muscle cells. Option D: It can increase cyclic AMP, which is associated with relaxation of bronchial smooth muscle and inhibition of release of hypersensitivity mediators from mast cells in the lungs. " A 5284603 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)OC)O4)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It primarily affects mu-type opioid receptors, which function as modulators of synaptic transmission via G-proteins. Option B: It is the prototypical agonist at nicotinic cholinergic receptors, dramatically stimulating neurons and ultimately blocking synaptic transmission. Option C: It primarily affects OP3 receptors, which function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Option D: It dramatically stimulates neurons and ultimately blocks synaptic transmission as the prototypical agonist at nicotinic cholinergic receptors. " A 243 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has a decreased incidence of adverse effects compared to high dose monotherapy in the treatment of moderate hypertension. Option B: It is known to exacerbate psychopathological symptoms in schizophrenic patients, but there is no evidence of similar effects in healthy subjects. Option C: It does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. Option D: It can cause a drop of 21% in Total Positive and Negative Syndrome Scale scores compared to placebo. " D 6288 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]([C@@H](C(=O)O)N)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can lead to the accumulation of itself and glycine in the brain when its plasma concentrations increase. Option B: It may inhibit the action of pepsin by subsequent increases in pH. Option C: Acute inhalation exposure to it can cause irritation of the respiratory tract and eye irritation in humans. Option D: It blocks the effects of excessive levels of glutamate that may lead to neuronal dysfunction. " A 115224 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CSC(=NC#N)N1CC2=CN=C(C=C2)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option B: It has therapeutic effects similar to salicylates, but lacks anti-inflammatory, antiplatelet, and gastric ulcerative effects. Option C: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and receptor blockage at high levels, leading to paralysis and death. Option D: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and blockage of the receptors at high levels, leading to paralysis and death. " D 6568 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option B: Prolonged and repeated contact with it may cause defatting and drying of the skin. Option C: It impairs energy-requiring processes, such as recovery from potentially lethal damage induced by radiation treatment and some cytotoxic drugs. Option D: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. " B 5282448 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CO[C@@H]1[C@@H]([C@H]([C@@H]([C@H](O1)COS(=O)(=O)O)O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](O2)C(=O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)COS(=O)(=O)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)C(=O)O)O[C@@H]5[C@@H]([C@H]([C@@H]([C@H](O5)COS(=O)(=O)O)O)O)NS(=O)(=O)O)O)O)OS(=O)(=O)O)NS(=O)(=O)O)O)OS(=O)(=O)O)O)NS(=O)(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It impairs energy-requiring processes, such as recovery from potentially lethal damage induced by radiation treatment and some cytotoxic drugs. Option B: It can potentiate the neutralizing action of ATIII on activated Factor X 300-fold. Option C: It causes longstanding nicotinic receptor activation, resulting in spastic paralysis of susceptible nematodes (worms). Option D: It interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, such as cisplatin, in killing cancer cells. " B 4616 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can lead to the accumulation of itself and glycine in the brain when its plasma concentrations increase. Option B: It may inhibit the action of pepsin by subsequent increases in pH. Option C: It can increase chloride conductance in the presence of GABA by prolonging the time in which the channel remains open. Option D: It blocks the effects of excessive levels of glutamate that may lead to neuronal dysfunction. " C 5280795 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](CCCC(C)C)[C@H]1CC[C@@H]\\2[C@@]1(CCC/C2=C\\C=C/3\\C[C@H](CCC3=C)O)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can activate transcription in most cases, but it can also suppress transcription in certain situations. Option B: It leads to aberrant cell growth and proliferation in some cancers. Option C: It results in the formation of defective cell walls and cell death by binding to certain enzymes. Option D: It is associated with transient serum enzyme elevations during therapy and with rare instances of acute liver injury. " A 271 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Ca+2] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can dilate systemic and pulmonary arterial vascular beds. Option B: It exhibits decreased platelet production as its physiologic effect. Option C: It leads to cranial blood vessel constriction. Option D: Getting too much of it can cause constipation. " D 54675769 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CC2=C1OC(=O)C(=C2O)NC(=O)C3=CC(=C(C=C3)O)CC=C(C)C)O[C@H]4[C@@H]([C@@H]([C@H](C(O4)(C)C)OC)OC(=O)N)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It induces cell cycle arrest and apoptosis in various cancer cells. Option B: It induces apoptosis and displays antitumour effects. Option C: It can bind to DNA gyrase and block adenosine triphosphatase (ATPase) activity. Option D: It causes interstrand linkages in DNA resulting in cell apoptosis. " C 3869 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CCC1=CC=CC=C1)NCC(C2=CC(=C(C=C2)O)C(=O)N)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause a decrease in systemic arterial blood pressure and systemic vascular resistance without a substantial reduction in resting heart rate, cardiac output, or stroke volume, apparently because of its combined α- and β-adrenergic blocking activity. Option B: It blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors, depresses the release of hypothalamic and hypophyseal hormones, and affects basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. Option C: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option D: It is associated with numerous side effects including dizziness, drowsiness, nausea, vomiting, diarrhea, headache, aphasia, lack of concentration, psychomotor retardation, speech disturbances, ataxia, depression, and hyponatremia. " A 40585 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1([C@H]([C@H]1C(=O)O[C@H](C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C=C(Br)Br)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is known to exacerbate psychopathological symptoms in schizophrenic patients, but there is no evidence of similar effects in healthy subjects. Option B: It has reproductive effects in women exposed by inhalation to high levels and adverse effects on the developing fetus in animal tests. Option C: It can temporarily attack the nervous system of any animal with which it comes into contact because it is a neurotoxin. Option D: It has the ability to cause serious adverse effects, including agranulocytosis. " C 5665 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC(CCC(=O)O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It may work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels. Option B: It is the prototypical agonist at nicotinic cholinergic receptors, dramatically stimulating neurons and ultimately blocking synaptic transmission. Option C: It dramatically stimulates neurons and ultimately blocks synaptic transmission as the prototypical agonist at nicotinic cholinergic receptors. Option D: It potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking cortical and limbic arousal following stimulation of the reticular pathways. " A 7923 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=O)OC1=O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: Acute inhalation exposure to it can cause irritation of the respiratory tract and eye irritation in humans. Option B: It causes severe respiratory tract irritation and inflammation in humans upon acute inhalation exposure. Option C: It causes central nervous system depression and irritation of the eyes and mucous membranes upon acute exposure in humans. Option D: It causes mucous membrane and eye irritation, and gastrointestinal effects. " A 6442177 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OCCO)C)/C)O)OC)C)C)/C)OC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits decreased platelet production as its physiologic effect. Option B: It exhibits decreased sympathetic activity as its physiologic effect. Option C: Its physiologic effect is by means of decreased immunologic activity. Option D: It exhibits decreased blood pressure as its physiologic effect. " C 4510 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(CO[N+](=O)[O-])O[N+](=O)[O-])O[N+](=O)[O-] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause irritation of the eyes, cough, wheezing, asthmatic symptoms, pulmonary edema, pneumonia, dizziness, weakness, headache, and chest pains. Option B: It can cause mental retardation, macrocephaly with cerebral atrophy, hypotonia, seizures, and involuntary movements in patients who have excess accumulation of D-2-hydroxyglutaric acid in the urine. Option C: Its antianginal effects were identified after it produced headaches in factory workers and relief from chest pain in workers with angina pectoris or heart failure. Option D: It is associated with numerous side effects including dizziness, drowsiness, nausea, vomiting, diarrhea, headache, aphasia, lack of concentration, psychomotor retardation, speech disturbances, ataxia, depression, and hyponatremia. " C 2130 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C2CC3CC1CC(C2)(C3)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It probably reflects an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake. Option B: It has reinforcing effects and inhibits dopamine uptake. Option C: It primarily affects mu-type opioid receptors, which function as modulators of synaptic transmission via G-proteins. Option D: It can increase norepinephrine and dopamine efflux throughout the brain, impair cognition, and have locomotor-activating effects. " A 4636 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=C(C(=C1CC2=NCCN2)C)O)C(C)(C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits vasoconstriction and increased sympathetic activity. Option B: It exhibits increased diuresis as its physiologic effect. Option C: It can cause increased cellular death. Option D: It exhibits increased cellular death as its physiologic effect. " A 5585 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=O)OC2=C1C=C3C=C(OC3=C2C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can lead to the accumulation of itself and glycine in the brain when its plasma concentrations increase. Option B: It induces apoptosis and displays antitumour effects. Option C: It results in the formation of defective cell walls and cell death by binding to certain enzymes. Option D: It causes interstrand linkages in DNA resulting in cell apoptosis. " D 5193 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(C)C1(C(=O)NC(=O)NC1=O)CC=C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It increases cellular permeability causing leakage of cellular contents by inhibiting the synthesis of ergosterol, an essential component of the fungal cell membrane. Option B: It is more potent and safer than ethinylestradiol, reducing the environmental accumulation of unwanted endocrine disrupting chemicals and harmful epigenetic effects. Option C: It can interfere with L-arginine in the production of nitric oxide, a key chemical to endothelial and hence cardiovascular health. Option D: It binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. " D 2118 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NN=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It dramatically stimulates neurons and ultimately blocks synaptic transmission as the prototypical agonist at nicotinic cholinergic receptors. Option B: It is the prototypical agonist at nicotinic cholinergic receptors, dramatically stimulating neurons and ultimately blocking synaptic transmission. Option C: It enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Option D: It induces oxidative stress in neurons by depleting glutathione through the activation of the metabotropic glutamate receptor 5. " C 38853 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It slows the heart rate in some patients. Option B: It can lead to decreased force and rate of heart contractions by blocking beta-adrenergic receptors in the heart. Option C: It can result in a decrease in heart rate and vascular resistance. Option D: It can lead to the accumulation of itself and glycine in the brain when its plasma concentrations increase. " A 5280373 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC=C(C=C1)C2=COC3=CC(=CC(=C3C2=O)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is associated with transient and usually mild elevations in serum aminotransferase during therapy and to rare instances of self-limited, clinically apparent idiosyncratic acute liver injury as well as to cases of reactivation of hepatitis B in susceptible individuals. Option B: It causes the accumulation of CYP1A1 mRNA and an increase in CYP1A1-specific 7-ethoxyresorufin O-deethylase (EROD) activity in a dose dependent manner. Option C: It has fewer side-effects and CNS stimulatory effects compared to the enantiomer (+)-(1S,2S)-Pseudoephedrine, while retaining its efficacy as a decongestant. Option D: It can lead to lower steady-state levels of HNE, and these cells acquire resistance to apoptosis induced by lipid peroxidation-causing agents such as H(2)O(2), UVA, superoxide anion, and pro-oxidant xenobiotics. " B 68617 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN[C@H]1CC[C@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option B: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. Option C: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option D: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. " C 2882 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC2=C(C(=C1)OCC(COC3=CC=CC4=C3C(=O)C=C(O4)C(=O)O)O)C(=O)C=C(O2)C(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It increases diuresis. Option B: It increases histamine release and cell-mediated immunity. Option C: It exhibits decreased histamine release. Option D: It can decrease histamine release. " C 6575 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=C(Cl)Cl)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: Chronic (long-term) exposure to it by inhalation in humans has resulted in effects on the respiratory tract, blood, kidney, liver, immune system, eyes, nose, and skin. Option B: It has liver, kidney, spleen, and central nervous system (CNS) effects in chronic (long-term) animal studies. Option C: It has cytotoxic effects on kidney and liver cells in vitro but only minor effects in vivo, due to its rapid metabolism and excretion. Option D: It has liver, kidney, immunological, endocrine, and developmental effects reported in humans. " D 991 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OC1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can affect the lungs, gastrointestinal system, blood, liver, kidneys, central nervous system, and eyes. Option B: It can affect the lungs, liver, kidneys, and heart. Option C: It affects the central nervous system, blood, respiratory system, eyes, and skin. Option D: Chronic (long-term) exposure to it by inhalation in humans has resulted in effects on the respiratory tract, blood, kidney, liver, immune system, eyes, nose, and skin. " C 4943 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C1=C(C(=CC=C1)C(C)C)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can exhibit general anesthesia as its physiologic effect. Option B: It can induce general anesthesia. Option C: It exhibits local anesthesia. Option D: It exhibits general anesthesia. " D 2809 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)C(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Option B: It primarily affects mu-type opioid receptors, which function as modulators of synaptic transmission via G-proteins. Option C: It is the prototypical agonist at nicotinic cholinergic receptors, dramatically stimulating neurons and ultimately blocking synaptic transmission. Option D: It mimics epilepsy by blocking the inhibitory action of GABA receptors. " A 7501 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC1=CC=CC=C1 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes mucous membrane and eye irritation, and gastrointestinal effects. Option B: It causes severe respiratory tract irritation and inflammation in humans upon acute inhalation exposure. Option C: Acute inhalation exposure to it can cause irritation of the respiratory tract and eye irritation in humans. Option D: It causes central nervous system depression and irritation of the eyes and mucous membranes upon acute exposure in humans. " A 3295 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC1=CC2=C(C=C1)N=C(S2)S(=O)(=O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause increased amount of this molecule in the blood of premature infants, which is marked by decreased motor activity, lethargy and poor feeding. Option B: It causes loss of potassium and an increase in serum uric acid. Option C: It decreases reabsorption of water, sodium, potassium, bicarbonate. Option D: It can cause retention of nitrogen, potassium, and phosphorus; increase protein anabolism; and decrease amino acid catabolism. " C 4054 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC12CC3CC(C1)(CC(C3)(C2)N)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes significant discomfort throughout the day and requires frequent treatment with eye drops. Option B: It blocks the effects of excessive levels of glutamate that may lead to neuronal dysfunction. Option C: It inhibits feeding and induces dramatic weight loss in mice. Option D: It may inhibit the action of pepsin by subsequent increases in pH. " B 7102 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option B: It produces headaches, lethargy, cyanosis, urinary burning, and hematuria in humans. Option C: It may cause gastritis, rhinitis, pharyngitis, laryngitis, and tracheobronchitis upon acute inhalation exposure. Option D: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. " B 66265 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN[C@@H](C)CC1=CC(=CC=C1)C(F)(F)F Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has few side effects and is reported to be safe and effective. Option B: It has cardiovascular side-effects. Option C: It has minimal side effects, with the most common being headache and fatigue. Option D: It causes a reduction in major cardiovascular events without significant side effects or risks. " B 15130 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@@H](C(C[C@H](C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2)OC(=O)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can stimulate the exchange of GTP for GDP on the G-protein complex when binding to the opiate. Option B: It can lead to the accumulation of itself and glycine in the brain when its plasma concentrations increase. Option C: It stimulates the exchange of GTP for GDP on the G-protein complex. Option D: It can stimulate the exchange of GTP for GDP on the G-protein complex. " C 45375808 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has long-lasting effects and can be administered once a day. Option B: It has minimal side effects, with the most common being headache and fatigue. Option C: It has side effects that are a cause for concern. Option D: It has few side effects and is reported to be safe and effective. " B 10184653 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes clinically apparent acute liver injury and rare instances of death. Option B: It can be associated with mild serum enzyme elevations and has been linked to rare instances of clinically apparent liver injury. Option C: It is associated with transient serum aminotransferase elevations during therapy and with rare instances of clinically apparent liver injury. Option D: It has a low rate of transient serum aminotransferase elevations during therapy and rare instances of clinically apparent liver injury. " A 56955933 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=[N-])=[N-].[Ca+2] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option B: It interferes with the normal metabolism of alcohol by preventing the breakdown of the metabolic product acetaldehyde. Option C: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option D: It can cause increased amount of this molecule in the blood of premature infants, which is marked by decreased motor activity, lethargy and poor feeding. " B 2202 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C2=C(C(=CC=C2)O)C(=O)C3=C1C=CC=C3O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It shows modest benefits in cognition and/or behavior in 6-12 month controlled studies. Option B: It impairs energy-requiring processes, such as recovery from potentially lethal damage induced by radiation treatment and some cytotoxic drugs. Option C: It is relatively innocuous, yet effective, and systemic side effects have not been observed. Option D: It does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. " C 10661 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C2=C(C(=O)N(C1=O)C)NC(=N2)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exerts a broad spectrum of stimulatory effects on cell metabolism. Option B: It inhibits DNA synthesis and has some cell cycle phase specificity. Option C: It inhibits DNA synthesis and causes cell death. Option D: It causes excitation by blocking the adenosine receptor. " D 73282 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NC(=NC(=N1)OC)NC(=O)NS(=O)(=O)C2=CC=CC=C2OCCCl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It increases cellular permeability causing leakage of cellular contents by inhibiting the synthesis of ergosterol, an essential component of the fungal cell membrane. Option B: It prevents cell division and stops plant growth by inhibiting the biosynthesis of essential branched-chain amino acids valine and isoleucine. Option C: It can inhibit ergosterol synthesis, resulting in increased cellular permeability causing leakage of cellular contents. Option D: It inhibits ergosterol synthesis, resulting in increased cellular permeability and leakage of cellular contents. " B 24261 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=[Si]=O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits respiratory toxicity when inhaled. Option B: It interferes with an enzyme pathway. Option C: It can exhibit general anesthesia effects. Option D: It exhibits general anesthesia. " A 12560 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)O)(C)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits decreased sympathetic activity as its physiologic effect. Option B: It exhibits decreased platelet production as its physiologic effect. Option C: It exhibits decreased blood pressure as its physiologic effect. Option D: It exhibits decreased sebaceous gland activity. " D 2756 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(N=CN1)CSCCNC(=NC)NC#N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It induces cell cycle arrest and apoptosis in various cancer cells. Option B: It induces apoptosis and displays antitumour effects. Option C: It causes interstrand linkages in DNA resulting in cell apoptosis. Option D: It blocks the activity of cytochrome P-450. " D 564 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCC(=O)O)CCN Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can exhibit decreased fibrinolysis effects. Option B: It exhibits decreased fibrinolysis. Option C: It exhibits decreased blood pressure. Option D: It can cause decreased blood pressure. " B 2082 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCSC1=CC2=C(C=C1)N=C(N2)NC(=O)OC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, inhibiting its polymerization or assembly into microtubules. Option B: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option C: It inhibits lateral shoot branching, stimulates germination of Striga, and aids in the symbiosis of over 80% of terrestrial plants with fungi at arbuscular mycorrihizae in roots. Option D: It can potentiate the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways. " A 2995 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It down-regulates cerebral cortical β-adrenergic receptors and sensitizes post-synaptic serotonergic receptors with chronic use, similar to TCAs. Option B: It blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors, depresses the release of hypothalamic and hypophyseal hormones, and affects basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. Option C: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option D: It down-regulates cerebral cortical β-adrenergic receptors and sensitizes post-synaptic serotonergic receptors with chronic use. " D 4192 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NC=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4F Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has a higher incidence of severe adverse effects compared to warfarin. Option B: It has a decreased incidence of adverse effects compared to high dose monotherapy in the treatment of moderate hypertension. Option C: It demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. Option D: It has a rapid onset of effects and short duration of action. " D 3039 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=O)(OC)OC=C(Cl)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It inhibits acetylcholinesterase, resulting in neurotoxic effects. Option B: It dramatically stimulates neurons and ultimately blocks synaptic transmission as the prototypical agonist at nicotinic cholinergic receptors. Option C: It increases acetylcholine neurotransmission by blocking its breakdown in the synaptic cleft. Option D: It is the prototypical agonist at nicotinic cholinergic receptors, dramatically stimulating neurons and ultimately blocking synaptic transmission. " A 32051 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Zn+2] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It decreases platelet aggregation. Option B: It exhibits decreased platelet aggregation. Option C: It exhibits decreased platelet production as its physiologic effect. Option D: It exhibits decreased copper ion absorption. " D 3034034 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC2=C(C=CN=C2C=C1)[C@H]([C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: The antimalarial effects are not well understood. Option B: It causes interstrand linkages in DNA resulting in cell apoptosis. Option C: It induces apoptosis and displays antitumour effects. Option D: It induces cell cycle arrest and apoptosis in various cancer cells. " A 5487427 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+]1([C@@H]2CC(C[C@H]1[C@H]3[C@@H]2O3)OC(=O)C(C4=CC=CS4)(C5=CC=CS5)O)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking cortical and limbic arousal following stimulation of the reticular pathways. Option B: It produces smooth muscle relaxation and bronchodilation by acting on M3 muscarinic receptors in the airways. Option C: It increases secretion by the exocrine glands, and produces contraction of the iris sphincter muscle and ciliary muscle (when given topically to the eyes) by mainly stimulating muscarinic receptors. Option D: It can increase cyclic AMP, which is associated with relaxation of bronchial smooth muscle and inhibition of release of hypersensitivity mediators from mast cells in the lungs. " B 5314 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can exhibit neuromuscular nondepolarizing blockade effects. Option B: It exhibits neuromuscular depolarizing blockade. Option C: It exhibits neuromuscular nondepolarizing blockade as its physiologic effect. Option D: It can reduce spasticity by increasing presynaptic inhibition of motor neurons. " B 9034 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC#CC(C)C1(C(=O)NC(=O)N(C1=O)C)CC=C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It binds to a distinct binding site associated with a Cl- ionopore at the GABA-A receptor, increasing the duration of time for which the Cl- ionopore is open. Option B: It binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. Option C: It can interfere with L-arginine in the production of nitric oxide, a key chemical to endothelial and hence cardiovascular health. Option D: It increases cellular permeability causing leakage of cellular contents by inhibiting the synthesis of ergosterol, an essential component of the fungal cell membrane. " A 5284596 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has shown similar efficacy to theophylline in the treatment of asthma, but with significantly fewer side effects in animal and human studies. Option B: It has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazine. Option C: It can cause increased amount of this molecule in the blood of premature infants, which is marked by decreased motor activity, lethargy and poor feeding. Option D: It has a high affinity for μ-opioid receptors and acts as an inverse agonist, causing the rapid removal of any other drugs bound to these receptors. " D 441244 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CN=C(N=C1)[N-]S(=O)(=O)C2=CC=C(C=C2)N.[Ag+] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause protein denaturation and enzyme inhibition. Option B: It can cause joint pain. Option C: It can cause increased cellular death. Option D: It can cause blindness. " A 31294 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(N)N.OO Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can alter enamel surface morphology via enamel mineral loss and surface roughening. Option B: It causes significant discomfort throughout the day and requires frequent treatment with eye drops. Option C: It causes severe respiratory tract irritation and inflammation in humans upon acute inhalation exposure. Option D: It causes mucous membrane and eye irritation, and gastrointestinal effects. " A 813 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [K+] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause increased large intestinal motility and inhibition of large intestine fluid/electrolyte absorption. Option B: It increases large intestinal motility and inhibits large intestine fluid/electrolyte absorption. Option C: It can potentiate the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways. Option D: It potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking cortical and limbic arousal following stimulation of the reticular pathways. " A 947 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: N#N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can help in removal of skin lesions through necrosis. Option B: It causes severe respiratory tract irritation and inflammation in humans upon acute inhalation exposure. Option C: Acute inhalation exposure to it can cause irritation of the respiratory tract and eye irritation in humans. Option D: It can cause respiratory effects from chronic inhalation exposure and skin irritation and sensitization from dermal exposure. " A 5280961 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause increased large intestinal motility and inhibition of large intestine fluid/electrolyte absorption. Option B: It increases large intestinal motility and inhibits large intestine fluid/electrolyte absorption. Option C: It can interfere with L-arginine in the production of nitric oxide, a key chemical to endothelial and hence cardiovascular health. Option D: It can rapidly activate endothelial nitric oxide synthase and production of nitric oxide in ECs. " D 6324 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause unexplained hypotension and conduction abnormalities in overdose situations. Option B: It can cause frostbite upon direct contact. Option C: It may cause convulsions after an apparent recovery. Option D: It can cause frostbite upon contact with the unconfined liquid. " B 59768 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(COC1=CC=C(C=C1)CCC(=O)OC)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can increase cyclic AMP, which is associated with relaxation of bronchial smooth muscle and inhibition of release of hypersensitivity mediators from mast cells in the lungs. Option B: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and receptor blockage at high levels, leading to paralysis and death. Option C: It can lead to decreased force and rate of heart contractions by blocking beta-adrenergic receptors in the heart. Option D: It leads to relaxation of smooth muscle in the prostate and detrusor muscles in the bladder, improving urinary flow. " C 5966 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(CCCCCCCCCCN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C)C(=O)OC2=CC=CC(=C2)[N+](C)(C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can increase cyclic AMP, which is associated with relaxation of bronchial smooth muscle and inhibition of release of hypersensitivity mediators from mast cells in the lungs. Option B: It can potentiate the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways. Option C: It can cause constriction of the iris sphincter muscle and the ciliary muscle in the eye. Option D: It potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking cortical and limbic arousal following stimulation of the reticular pathways. " C 667484 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C1=CN=CN1[C@H](C)C2=CC=CC=C2 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can exhibit general anesthesia as its physiologic effect. Option B: It can induce general anesthesia. Option C: It exhibits local anesthesia. Option D: It can exhibit general anesthesia effects. " B 5362124 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@H]2CCC3=CC=CC=C3N(C2=O)CC(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It decreases blood pressure. Option B: It can cause decreased blood pressure. Option C: It exhibits decreased blood pressure as its physiologic effect. Option D: It exhibits decreased blood pressure. " B 29393 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN(CCC)C1=C(C=C(C=C1[N+](=O)[O-])S(=O)(=O)N)[N+](=O)[O-] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can interfere with cell functions, such as meiosis and intracellular transportation, by binding to microtubules. Option B: It can disrupt (depolymerize) microtubules, blocking anisotropic growth of plant cells. Option C: It exhibits microtubule inhibition as its physiologic effect. Option D: It exhibits decreased mitosis and microtubule inhibition as its physiologic effects. " B 42008 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C(=NN=N1)SCC2=C(N3[C@@H]([C@@](C3=O)(NC(=O)CSCC#N)OC)SC2)C(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has a high rate of efficacy in many types of infection and no severe side effects have been noted. Option B: It has a higher incidence of severe adverse effects compared to warfarin. Option C: It has a decreased incidence of adverse effects compared to high dose monotherapy in the treatment of moderate hypertension. Option D: It demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. " A 949 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C1=CC=CC=C1 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: Acute inhalation exposure to it can cause irritation of the respiratory tract and eye irritation in humans. Option B: It causes severe respiratory tract irritation and inflammation in humans upon acute inhalation exposure. Option C: It can result in effects on the CNS, blood, and liver with chronic inhalation exposure. Option D: It can cause respiratory effects from chronic inhalation exposure and skin irritation and sensitization from dermal exposure. " C 60606 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)[C@H](C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It decreases prostaglandin production and platelet aggregation. Option B: It exhibits decreased platelet aggregation. Option C: It decreases platelet aggregation. Option D: It can decrease platelet aggregation. " D 311 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)O)C(CC(=O)O)(C(=O)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can decrease prothrombin activity to realize its physiologic effect. Option B: It can decrease cell membrane integrity to realize its physiologic effect. Option C: It can decrease coagulation factor activity to realize its physiologic effect. Option D: It can increase coagulation factor VIII activity and concentration to realize its physiologic effect. " C 25126798 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option B: It is associated with transient and usually mild elevations in serum aminotransferase during therapy and to rare instances of self-limited, clinically apparent idiosyncratic acute liver injury as well as to cases of reactivation of hepatitis B in susceptible individuals. Option C: It inhibits lateral shoot branching, stimulates germination of Striga, and aids in the symbiosis of over 80% of terrestrial plants with fungi at arbuscular mycorrihizae in roots. Option D: It blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors, depresses the release of hypothalamic and hypophyseal hormones, and affects basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. " B 222528 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can decrease cell membrane integrity to realize its physiologic effect. Option B: It exhibits decreased blood pressure as its physiologic effect. Option C: It can decrease blood pressure to realize its physiologic effect. Option D: It exhibits increased cellular death as its physiologic effect. " A 131204 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(CO)[C@H](C(=O)NCCCO)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can stimulate osteoblasts to release factors which stimulate bone resorption by osteoclasts. Option B: It can increase fibroblast proliferation and accelerate re-epithelialization in wound healing. Option C: It can increase cyclic AMP, which is associated with relaxation of bronchial smooth muscle and inhibition of release of hypersensitivity mediators from mast cells in the lungs. Option D: It leads to relaxation of smooth muscle in the prostate and detrusor muscles in the bladder, improving urinary flow. " B 3652 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause noncirrhotic portal hypertension due to hepatoportal sclerosis and nodular regenerative hyperplasia with long term therapy. Option B: It can inhibit the erythrocytic stage of development of plasmodia. Option C: It can cause increased large intestinal motility and inhibition of large intestine fluid/electrolyte absorption. Option D: It increases large intestinal motility and inhibits large intestine fluid/electrolyte absorption. " B 4980 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCC1=CNC2=C1C(=CC=C2)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has serious side effects including allergic reactions, irregular heartbeats, and low or high blood pressure, as well as less serious side effects such as headaches, insomnia, and impotence. Option B: It can cause highly variable and subjective mind-altering effects, resembling those caused by LSD and mescaline. Option C: It causes mild central nervous system effects, including dizziness, giddiness, slight nausea, and headache. Option D: Its antianginal effects were identified after it produced headaches in factory workers and relief from chest pain in workers with angina pectoris or heart failure. " B 439391 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(=O)O)[C@H](C(=O)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option B: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option C: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option D: It can cause mental retardation, macrocephaly with cerebral atrophy, hypotonia, seizures, and involuntary movements in patients who have excess accumulation of D-2-hydroxyglutaric acid in the urine. " D 4107 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC=CC=C1OCC(COC(=O)N)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits decreased blood pressure as its physiologic effect. Option B: It can exhibit centrally-mediated muscle relaxation as its physiologic effect. Option C: It exhibits decreased platelet production as its physiologic effect. Option D: It exhibits decreased sympathetic activity as its physiologic effect. " B 20058 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=CC(=O)NC2=O)OC(=O)C)OC(=O)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can improve efficacy and reduce toxic side effects of higher doses of 5-FU when pre-administered with uridine. Option B: It has a decreased incidence of adverse effects compared to high dose monotherapy in the treatment of moderate hypertension. Option C: It allows for better treatment outcomes and a decreased side effect profile by increasing systemic exposure of anti-retrovirals (ARVs) without increasing dosage. Option D: It has shown similar efficacy to theophylline in the treatment of asthma, but with significantly fewer side effects in animal and human studies. " A 39765 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@@H]([C@]2(C[C@@H]1N4CCCCC4)C)CC[C@]5([C@H]3C[C@@H]([C@@H]5OC(=O)C)[N+]6(CCCCC6)C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can exhibit neuromuscular nondepolarizing blockade effects. Option B: It can exhibit neuromuscular nondepolarizing blockade as its physiologic effect. Option C: It exhibits neuromuscular depolarizing blockade. Option D: It exhibits neuromuscular nondepolarizing blockade as its physiologic effect. " B 6011 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@]2([C@@H](CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@H]4O)C)CC1=O)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause retention of nitrogen, potassium, and phosphorus; increase protein anabolism; and decrease amino acid catabolism. Option B: It can cause increased amount of this molecule in the blood of premature infants, which is marked by decreased motor activity, lethargy and poor feeding. Option C: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and receptor blockage at high levels, leading to paralysis and death. Option D: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and blockage of the receptors at high levels, leading to paralysis and death. " A 3647 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1NC2=C(C=C(C(=C2)C(F)(F)F)S(=O)(=O)N)S(=O)(=O)N1 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits increased cellular death as its physiologic effect. Option B: It can exhibit increased diuresis as its physiologic effect. Option C: It exhibits increased diuresis as its physiologic effect. Option D: It exhibits increased diuresis at the loop of Henle as its physiologic effect. " B 439918 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@@H](C(=O)O)N=C(N)N)C(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is associated with transient and usually mild elevations in serum aminotransferase during therapy and to rare instances of self-limited, clinically apparent idiosyncratic acute liver injury as well as to cases of reactivation of hepatitis B in susceptible individuals. Option B: It can cause a decline in hepatic levels of the semi-essential amino acid, arginine, due to the rising level of urea, resulting in the oxidation of arginine. Option C: It can cause noncirrhotic portal hypertension due to hepatoportal sclerosis and nodular regenerative hyperplasia with long term therapy. Option D: It can cause transient serum enzyme elevations during therapy, rare cases of cholestatic hepatitis, instances of nodular regenerative hyperplasia, and sinusoidal obstruction syndrome when given in high doses. " B 60961 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes severe respiratory tract irritation and inflammation in humans upon acute inhalation exposure. Option B: It can cause transient heart block in the AV node when administered intravenously. Option C: It causes significant discomfort throughout the day and requires frequent treatment with eye drops. Option D: Acute inhalation exposure to it can cause irritation of the respiratory tract and eye irritation in humans. " B 2795 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCC(C1=CC=CC=C1)(C2=CC=CC=C2Cl)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It leads to relaxation of smooth muscle in the prostate and detrusor muscles in the bladder, improving urinary flow. Option B: It can suppress the cough reflex by a direct effect on the cough center in the medulla of the brain. Option C: It can lead to the accumulation of itself and glycine in the brain when its plasma concentrations increase. Option D: It can lead to decreased force and rate of heart contractions by blocking beta-adrenergic receptors in the heart. " B 5284371 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@H](C=C4)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can stimulate the exchange of GTP for GDP on the G-protein complex when binding to the opiate. Option B: It stimulates the exchange of GTP for GDP on the G-protein complex. Option C: It causes interstrand linkages in DNA resulting in cell apoptosis. Option D: It can stimulate the exchange of GTP for GDP on the G-protein complex. " A 126941 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can suppress hunger signals and appetite. Option B: It causes harmful health effects and bioaccumulates. Option C: It can suppress inflammation and prevent cell division through inhibition. Option D: It suppresses hunger signals and appetite. " C 2088 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It interferes with osteoclast function and survival. Option B: It can stimulate osteoblasts to release factors which stimulate bone resorption by osteoclasts. Option C: It can result in epigenetic silencing that affects neuroendocrine differentiation. Option D: It is associated with seizures, delayed development, and neurocognitive impairment. " A 168871 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]3(N1C(=O)[C@](O3)(C(C)C)NC(=O)[C@@H]4C[C@H]5[C@@H](CC6=CNC7=CC=CC5=C67)N(C4)C)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It presents very large hypotensive effects. Option B: It exhibits hypotensive and neuroprotective effects. Option C: It has a very high potency and a comparable side effect profile to the parent compound. Option D: It has similar biological activity as antivirals and neuroprotective effects. " A 3385 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=O)NC(=O)N1)F Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes loss of potassium and an increase in serum uric acid. Option B: It blocks the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. Option C: It reduces serum uric acid levels by inhibiting the activity of an enzyme responsible for the synthesis of uric acid. Option D: It can reduce serum uric acid concentration through the inhibition of URAT1 and OAT4. " B 2244 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)OC1=CC=CC=C1C(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It decreases prostaglandin production and platelet aggregation. Option B: It can increase prostaglandin activity to realize its physiologic effect. Option C: It decreases prostaglandin production. Option D: It inhibits prostaglandin synthesis. " A 60854 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(CCN1CCC2=C(C=C3C(=C2)CC(=O)N3)Cl)C4=NSC5=CC=CC=C54 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has a higher incidence of severe adverse effects compared to warfarin. Option B: It demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. Option C: It has a decreased incidence of adverse effects compared to high dose monotherapy in the treatment of moderate hypertension. Option D: It has a lower incidence of metabolic adverse effects compared to other medications in the same class. " D 2327 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C(=C1CNNC(=O)C(CO)N)O)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can reversibly stabilize the neuronal membrane by binding to sodium channels. Option B: It acts to minimize the occurrence of extracerebral side effects. Option C: It can lead to the accumulation of itself and glycine in the brain when its plasma concentrations increase. Option D: It may have a narcotic effect in high concentrations. " B 179344 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)O[C@H]1CC2=CC=CC=C2N(C3=CC=CC=C13)C(=O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause edemas, hemorrhages, hematomas, abnormal development of the brain, abnormal development of the visceral cranium, abnormal development of the genitourinary system, decreased size of pelvic bones, decreased size of shoulder girdle, decreased size of front and hind limbs, etc. Option B: It is associated with numerous side effects including dizziness, drowsiness, nausea, vomiting, diarrhea, headache, aphasia, lack of concentration, psychomotor retardation, speech disturbances, ataxia, depression, and hyponatremia. Option C: It blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors, depresses the release of hypothalamic and hypophyseal hormones, and affects basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. Option D: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. " B 2519 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C=NC2=C1C(=O)N(C(=O)N2C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It stimulates the central nervous system. Option B: It exhibits central nervous system depression. Option C: It can stimulate the central nervous system. Option D: It exhibits central nervous system stimulation as its physiologic effect. " A 2879 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. Option B: It is known to exacerbate psychopathological symptoms in schizophrenic patients, but there is no evidence of similar effects in healthy subjects. Option C: It decreases the serum p-cresol concentration in uremic patients. Option D: It has been associated with fever, mild jaundice and clinically apparent liver injury in up to 2% of treated patients. " C 5280493 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC/C=C\\C/C=C\\C=C\\C=C\\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause inhibition of the action of angiotensin II on vascular smooth muscle, leading to a reduction in arterial blood pressure. Option B: It can increase cyclic AMP, which is associated with relaxation of bronchial smooth muscle and inhibition of release of hypersensitivity mediators from mast cells in the lungs. Option C: It stimulates mucus secretion in the lung and produces contractions of nonvascular and some vascular smooth muscle. Option D: It leads to relaxation of smooth muscle in the prostate and detrusor muscles in the bladder, improving urinary flow. " C 1493 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It dissociates from opioid receptors very slowly, resulting in a long duration of action and relief from pain or withdrawal symptoms for upwards of 24-36 hours. Option B: It can cause episodes of epidermal necrosis without significant long-term effects and post-sclerosis pigmentation that resolved within a few months. Option C: It uncouples oxidative phosphorylation and leads to a rapid consumption of energy without generation of ATP. Option D: It can cause increased amount of this molecule in the blood of premature infants, which is marked by decreased motor activity, lethargy and poor feeding. " C 3696 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It down-regulates cerebral cortical β-adrenergic receptors and sensitizes post-synaptic serotonergic receptors with chronic use. Option B: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option C: It blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors, depresses the release of hypothalamic and hypophyseal hormones, and affects basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. Option D: It down-regulates cerebral cortical β-adrenergic receptors and sensitizes post-synaptic serotonergic receptors with chronic use, similar to TCAs. " A 443884 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](CO)NC(=O)[C@H]1CN([C@@H]2CC3=CNC4=CC=CC(=C34)C2=C1)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It directly stimulates the uterine muscle to increase force and frequency of contractions. Option B: It stimulates mucus secretion in the lung and produces contractions of nonvascular and some vascular smooth muscle. Option C: It decreases contractility of the uterine smooth muscle. Option D: It induces bronchodilation by relaxation of airway smooth muscles. " A 55245 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC#C[C@@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It increases secretion by the exocrine glands, and produces contraction of the iris sphincter muscle and ciliary muscle (when given topically to the eyes) by mainly stimulating muscarinic receptors. Option B: It can potentiate the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways. Option C: It inhibits lateral shoot branching, stimulates germination of Striga, and aids in the symbiosis of over 80% of terrestrial plants with fungi at arbuscular mycorrihizae in roots. Option D: It induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua through its inhibition of progesterone. " D 148124 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can disrupt (depolymerize) microtubules, blocking anisotropic growth of plant cells. Option B: It can interfere with cell functions, such as meiosis and intracellular transportation, by binding to microtubules. Option C: It exhibits microtubule inhibition as its physiologic effect. Option D: It exhibits decreased mitosis and microtubule inhibition as its physiologic effects. " C 2471 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCNC1=C(C(=CC(=C1)C(=O)O)S(=O)(=O)N)OC2=CC=CC=C2 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits increased diuresis at the loop of Henle as its physiologic effect. Option B: It exhibits increased cellular death as its physiologic effect. Option C: It exhibits increased diuresis as its physiologic effect. Option D: It can exhibit increased diuresis as its physiologic effect. " A 66461 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(CN1C=NC=N1)(C2=C(C=C(C=C2)Cl)Cl)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has a broad spectrum of action, being systemic with protective and curative action. Option B: It has a comparatively favorable adverse effect profile. Option C: It can produce significant adverse effects in the GI tract. Option D: It has a very high potency and a comparable side effect profile to the parent compound. " A 3059 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1C2=C(C=C(C=C2)F)F)C(=O)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause transient mild-to-moderate serum aminotransferase elevations during the first 1 or 2 weeks of treatment, but has not been implicated in cases of clinically apparent liver injury with jaundice. Option B: It is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy that are usually accompanied by an increase in hepatic fat. Option C: It has been linked to mild, transient elevations in serum aminotransferase levels during therapy as well as rare instances of idiosyncratic drug-induced liver disease. Option D: It is associated with elevations in serum aminotransferase levels, acute liver injury, and noncirrhotic portal hypertension with long-term use. " C 7434 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C=C1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It interferes with an enzyme pathway. Option B: It exhibits general anesthesia. Option C: It appears as a high explosive. Option D: It may have a narcotic effect in high concentrations. " C 778 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CS)C(C(=O)O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is associated with moderate hyperhomocysteinemia, especially in the context of marginal folate intake, due to a polymorphism of methylenetetrahydrofolate reductase (C677T). Option B: It can cause noncirrhotic portal hypertension due to hepatoportal sclerosis and nodular regenerative hyperplasia with long term therapy. Option C: It can cause transient serum enzyme elevations during therapy, rare cases of cholestatic hepatitis, instances of nodular regenerative hyperplasia, and sinusoidal obstruction syndrome when given in high doses. Option D: It is associated with transient and usually mild elevations in serum aminotransferase during therapy and to rare instances of self-limited, clinically apparent idiosyncratic acute liver injury as well as to cases of reactivation of hepatitis B in susceptible individuals. " A 160355 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=C3 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option B: It inhibits the expression of involucrin (hINV), a marker of keratinocyte differentiation, via a protein kinase Cdelta (PKCdelta), Ras, MEKK1, MEK3 cascade that increases AP1 factor level and AP1 factor binding to DNA elements in the hINV promoter. Option C: It preferentially inhibits multiple enzyme targets including CDK2, CDK7, and CDK9, altering the growth phase of treated cells as a cyclin-dependent kinase (CDK) inhibitor. Option D: It blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors, depresses the release of hypothalamic and hypophyseal hormones, and affects basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. " C 3331 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(COC(=O)N)COC(=O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits decreased central nervous system disorganized electrical activity as its physiologic effect. Option B: It can decrease central nervous system disorganized electrical activity. Option C: It can decrease central nervous system disorganized electrical activity to realize its physiologic effect. Option D: It decreases central nervous system disorganized electrical activity. " A 323 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC(=O)O2 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option B: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option C: It causes liver tumors in rats and mice and Clara cell toxicity and lung tumors in mice, although adverse effects in humans following exposure are rare and only associated with clinical doses. Option D: It can cause transient serum enzyme elevations during therapy, rare cases of cholestatic hepatitis, instances of nodular regenerative hyperplasia, and sinusoidal obstruction syndrome when given in high doses. " C 3305 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(O)(P(=O)(O)O)P(=O)(O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: By inhibiting the endogenous production of cholesterol within the liver, it lowers abnormal cholesterol and lipid levels and ultimately reduces the risk of cardiovascular disease. Option B: It can increase cyclic AMP, which is associated with relaxation of bronchial smooth muscle and inhibition of release of hypersensitivity mediators from mast cells in the lungs. Option C: It prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction by inhibiting the influx of calcium in smooth muscle cells. Option D: It decreases serum calcium by inhibiting tumor-induced bone resorption and reducing calcium flow from the resorbing bone into the blood in malignancy-related hypercalcemia. " D 4601 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can exhibit centrally-mediated muscle relaxation as its physiologic effect. Option B: It exhibits centrally-mediated muscle relaxation. Option C: It causes centrally-mediated muscle relaxation. Option D: It exhibits decreased sympathetic activity as its physiologic effect. " B 6574 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)Cl)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes central nervous system depression and irritation of the eyes and mucous membranes upon acute exposure in humans. Option B: It causes stinging and burning sensations of the skin upon dermal exposure. Option C: It causes severe respiratory tract irritation and inflammation in humans upon acute inhalation exposure. Option D: It can cause respiratory effects from chronic inhalation exposure and skin irritation and sensitization from dermal exposure. " B 4771 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(CC1=CC=CC=C1)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can suppress appetite. Option B: It suppresses hunger signals and appetite. Option C: It causes harmful health effects and bioaccumulates. Option D: It causes centrally-mediated muscle relaxation. " B 2727 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option B: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option C: By inhibiting the endogenous production of cholesterol within the liver, it lowers abnormal cholesterol and lipid levels and ultimately reduces the risk of cardiovascular disease. Option D: It increases peripheral glucose utilization, decreases hepatic gluconeogenesis, and may increase the number and sensitivity of insulin receptors. " D 3676 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CC(=O)NC1=C(C=CC=C1C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can exhibit general anesthesia as its physiologic effect. Option B: It exhibits local anesthesia as its physiologic effect. Option C: It exhibits general anesthesia. Option D: It exhibits local anesthesia. " D 31401 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It changes the composition of bile and may dissolve gallstones. Option B: It exhibits cardiac rhythm alteration as its physiologic effect. Option C: It exhibits decreased sympathetic activity as its physiologic effect. Option D: It exhibits decreased platelet production as its physiologic effect. " A 3121 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(CCC)C(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can decrease central nervous system disorganized electrical activity. Option B: It exhibits decreased central nervous system disorganized electrical activity. Option C: It decreases central nervous system disorganized electrical activity. Option D: It exhibits a decreased central nervous system disorganized electrical activity. " B 10657292 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)[C@H]([C@@H]1CCCCN1)C2=CC=CC=C2 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits central nervous system stimulation. Option B: It exhibits central nervous system depression. Option C: It can stimulate the central nervous system. Option D: It stimulates the central nervous system. " A 5504 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN=C(N1)CC2=CC=CC=C2 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: The antimalarial effects are not well understood. Option B: It results in the formation of defective cell walls and cell death by binding to certain enzymes. Option C: It induces apoptosis and displays antitumour effects. Option D: The mechanisms of its therapeutic effects are not clear. " D 241 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=CC=C1 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option B: It has shown similar efficacy to theophylline in the treatment of asthma, but with significantly fewer side effects in animal and human studies. Option C: It has reproductive effects in women exposed by inhalation to high levels and adverse effects on the developing fetus in animal tests. Option D: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. " C 5961 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(=O)N)[C@@H](C(=O)O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option B: It has a minimal side effect profile and uncomplicated metabolic profile, making it suitable for the treatment of mycotic outbreaks such as vaginal yeast infections and athlete's foot. Option C: It aids maintenance of gut barrier function, intestinal cell proliferation and differentiation, and reduces septic morbidity and the symptoms of Irritable Bowel Syndrome. Option D: It has therapeutic effects similar to salicylates, but lacks anti-inflammatory, antiplatelet, and gastric ulcerative effects. " C 4499 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits decreased blood pressure as its physiologic effect. Option B: It decreases blood pressure. Option C: It can cause decreased blood pressure. Option D: It exhibits decreased blood pressure. " D 4091 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C(=N)N=C(N)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: Its major side effects are myelosuppression and neurotoxicity. Option B: It causes asthma, dyspnea, and other respiratory impairments in workers. Option C: It causes severe respiratory tract irritation and inflammation in humans upon acute inhalation exposure. Option D: Its main side effects are dyspepsia, nausea, and diarrhea. " D 7172 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNCC(C1=CC=C(C=C1)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has longer acting adrenergic effects compared to norepinephrine. Option B: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and blockage of the receptors at high levels, leading to paralysis and death. Option C: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and receptor blockage at high levels, leading to paralysis and death. Option D: It can increase norepinephrine and dopamine efflux throughout the brain, impair cognition, and have locomotor-activating effects. " A 4906 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCNC(C)C(=O)NC1=CC=CC=C1C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can induce general anesthesia. Option B: It can exhibit general anesthesia as its physiologic effect. Option C: It exhibits general anesthesia. Option D: It exhibits local anesthesia. " D 4917 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option B: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. Option C: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option D: It blocks the D2 somatodendritic autoreceptor, resulting in the blockade of postsynaptic dopamine receptors in the mesolimbic system and an increased dopamine turnover. " D 2801 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors, depresses the release of hypothalamic and hypophyseal hormones, and affects basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. Option B: It potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking cortical and limbic arousal following stimulation of the reticular pathways. Option C: It down-regulates cerebral cortical β-adrenergic receptors and sensitizes post-synaptic serotonergic receptors with chronic use. Option D: It can potentiate the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways. " C 33032 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(=O)O)[C@@H](C(=O)O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes calcium ions to enter cells via NMDA receptor channels, leading to neuronal damage and eventual cell death. Option B: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option C: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and receptor blockage at high levels, leading to paralysis and death. Option D: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and blockage of the receptors at high levels, leading to paralysis and death. " A 3690 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(P(=O)(OC1)NCCCl)CCCl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes interstrand linkages in DNA resulting in cell apoptosis. Option B: It induces apoptosis and displays antitumour effects. Option C: It forms inter and intra strand cross-links in the DNA, resulting in cell death. Option D: It inhibits DNA synthesis and causes cell death. " C 9864 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(#N)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option B: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option C: It inhibits lateral shoot branching, stimulates germination of Striga, and aids in the symbiosis of over 80% of terrestrial plants with fungi at arbuscular mycorrihizae in roots. Option D: It may cause gastritis, rhinitis, pharyngitis, laryngitis, and tracheobronchitis upon acute inhalation exposure. " D 71496458 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is developed in response to altered tumour resistance patterns following treatment and toxic side effects that impact patient quality of life. Option B: It has reproductive effects in women exposed by inhalation to high levels and adverse effects on the developing fetus in animal tests. Option C: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option D: It causes debilitating symptoms, significant functional limitations, and a reduced quality of life in patients with tenosynovial giant cell tumors. " A 6354 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CO1 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: Acute inhalation exposure to it can cause irritation of the respiratory tract and eye irritation in humans. Option B: Acute exposure to this molecule affects the blood with clinical signs of central nervous system depression. Option C: It causes central nervous system depression and irritation of the eyes and mucous membranes upon acute exposure in humans. Option D: It can have effects on the liver and central nervous system from oral exposure in animal studies. " C 11338033 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CNCCC1NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It selectively inhibits certain Cyclin Dependent Kinases (CDKs), leading to tumour regression. Option B: It leads to aberrant cell growth and proliferation in some cancers. Option C: It induces cell death and growth arrest in Burkitt lymphoma cell lines at low concentrations. Option D: It mimics epilepsy by blocking the inhibitory action of GABA receptors. " A 2771 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option B: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. Option C: It can block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option D: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. " B 5288826 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](C=C4)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It induces apoptosis and displays antitumour effects. Option B: It likely plays a role in the expression of analgesic effects by binding to specific CNS opiate receptors. Option C: It induces cell cycle arrest and apoptosis in various cancer cells. Option D: It exerts analgesic and antipyretic effects. " B 54454 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C)(C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It raises blood sugar through activation of hepatic receptors, stimulating glycogenolysis and the release of glucose. Option B: It increases breakdown of LDL cholesterol by inducing hepatic LDL receptors. Option C: It can increase peripheral glucose utilization, decrease hepatic gluconeogenesis, and may increase the number and sensitivity of insulin receptors. Option D: It decreases hepatic cholesterol levels, increases hepatic uptake of cholesterol, and reduces plasma cholesterol levels. " B 5253 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits decreased blood pressure as its physiologic effect. Option B: It can decrease blood pressure to realize its physiologic effect. Option C: It exhibits decreased sympathetic activity as its physiologic effect. Option D: It exhibits cardiac rhythm alteration as its physiologic effect. " D 7847 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC=O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: Acute inhalation exposure to it can cause irritation of the respiratory tract and eye irritation in humans. Option B: It may result in upper respiratory tract irritation and congestion. Option C: It causes severe respiratory tract irritation and inflammation in humans upon acute inhalation exposure. Option D: It causes central nervous system depression and irritation of the eyes and mucous membranes upon acute exposure in humans. " B 27189 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)C(=O)C(C)OC1=CC=CC2=CC=CC=C21 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It inhibits DNA synthesis and causes cell death. Option B: It inhibits DNA synthesis and stops the growth of cancer cells. Option C: It inhibits feeding and induces dramatic weight loss in mice. Option D: It inhibits root development and growth. " D 49806720 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC1=CC2=C(C=C1N3CCC(CC3)N4CCOCC4)C(C5=C(C2=O)C6=C(N5)C=C(C=C6)C#N)(C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It prevents phosphorylation and subsequent downstream activation of STAT3 and AKT resulting in reduced tumour cell viability. Option B: It increases peripheral glucose utilization, decreases hepatic gluconeogenesis, and may increase the number and sensitivity of insulin receptors. Option C: It improves cardiac function, reduces afterload, increases cardiac output, and prevents ventricular hypertrophy and remodeling. Option D: It can increase peripheral glucose utilization, decrease hepatic gluconeogenesis, and may increase the number and sensitivity of insulin receptors. " A 10800 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC(=C1O)[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It affects the central nervous system, blood, respiratory system, eyes, and skin. Option B: Chronic (long-term) exposure to it by inhalation in humans has resulted in effects on the respiratory tract, blood, kidney, liver, immune system, eyes, nose, and skin. Option C: It affects the respiratory, cardiovascular, gastrointestinal, and central nervous system (CNS) of chronically exposed workers. Option D: It can affect the lungs, gastrointestinal system, blood, liver, kidneys, central nervous system, and eyes. " C 124087 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is irritant but produces no acute systemic effects and has no demonstrable genotoxic potential. Option B: It does not cause drowsiness or anticholinergic side effects. Option C: It has good tolerance, lack of toxicity, and no dose-limiting side effects. Option D: It does not cause drowsiness because it does not readily enter the central nervous system. " D 2444 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCOC(C1=CC=CC=C1)C2=CC=C(C=C2)Br Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. Option B: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. Option C: It antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. Option D: It can antagonize the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. " C 7570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CC2=CC=C(C=C2)N=C=O)N=C=O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes asthma, dyspnea, and other respiratory impairments in workers. Option B: It can cause metabolic acidosis, intracranial hemorrhage, feeding difficulties, and significant neurological symptoms. Option C: It causes respiratory effects such as respiratory irritation, wheezing, asthma, pneumonia, and fibrosis with chronic (long-term) inhalation exposure. Option D: It has therapeutic effects similar to salicylates, but lacks anti-inflammatory, antiplatelet, and gastric ulcerative effects. " A 444 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It interrupts addiction. Option B: It suppresses hunger signals and appetite. Option C: It can suppress appetite. Option D: It decreases blood pressure. " A 977 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can be associated with mild serum enzyme elevations and has been linked to rare instances of clinically apparent liver injury. Option B: It can be introduced under normobaric or hyperbaric conditions. Option C: It is relatively innocuous, yet effective, and systemic side effects have not been observed. Option D: It can be poisonous or even fatal to organisms in sufficient amounts. " B 5462501 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](C(=O)N1CCC[C@H]1C(=O)O)N[C@@H](CCC2=CC=CC=C2)C(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause decreased blood pressure. Option B: It exhibits decreased blood pressure as its physiologic effect. Option C: It exhibits decreased blood pressure. Option D: It decreases blood pressure. " D 4735 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is associated with transient serum aminotransferase elevations during therapy and with rare instances of clinically apparent liver injury. Option B: It has a low rate of transient serum aminotransferase elevations during therapy and rare instances of clinically apparent liver injury. Option C: It can be associated with mild serum enzyme elevations and has been linked to rare instances of clinically apparent liver injury. Option D: It is associated with transient serum enzyme elevations during therapy and with rare instances of acute liver injury. " A 3672 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CC1=CC=C(C=C1)C(C)C(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option B: It achieves analgesic, antipyretic, and anti-inflammatory activity through COX-2 inhibition, and unwanted effects on platelet aggregation and the GI mucosa through COX-1 inhibition. Option C: It can lead to lower steady-state levels of HNE, and these cells acquire resistance to apoptosis induced by lipid peroxidation-causing agents such as H(2)O(2), UVA, superoxide anion, and pro-oxidant xenobiotics. Option D: It inhibits lateral shoot branching, stimulates germination of Striga, and aids in the symbiosis of over 80% of terrestrial plants with fungi at arbuscular mycorrihizae in roots. " B 11715 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)CBr Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits decreased platelet production as its physiologic effect. Option B: It leads to cranial blood vessel constriction. Option C: It is a violent lachrymator and may have adverse health effects. Option D: It may result in upper respiratory tract irritation and congestion. " C 16004 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=NC(=C1)Cl)C(Cl)(Cl)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes significant discomfort throughout the day and requires frequent treatment with eye drops. Option B: It inhibits nitrification in grain and reduces nitrogen losses from arable land. Option C: It inhibits feeding and induces dramatic weight loss in mice. Option D: It causes overexcitation, paralysis, and death in insects. " B 41781 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC=C1)NC2=C(C=NC=C2)S(=O)(=O)NC(=O)NC(C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits increased diuresis at the loop of Henle as its physiologic effect. Option B: It can exhibit increased diuresis as its physiologic effect. Option C: It exhibits increased diuresis as its physiologic effect. Option D: It increases diuresis at Loop of Henle. " D 6058 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CS)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes significant discomfort throughout the day and requires frequent treatment with eye drops. Option B: Acute inhalation exposure to it can cause irritation of the respiratory tract and eye irritation in humans. Option C: It causes severe respiratory tract irritation and inflammation in humans upon acute inhalation exposure. Option D: It causes central nervous system depression and irritation of the eyes and mucous membranes upon acute exposure in humans. " A 439501 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@H]2C[C@H]([C@@]3([C@@H]4[C@@H](CC[C@@]3(C2)O)[C@]5(CC[C@@H]([C@]5(C[C@H]4O)C)C6=CC(=O)OC6)O)CO)O)O)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can reversibly stabilize the neuronal membrane by binding to sodium channels. Option B: It inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Option C: It can lead to the accumulation of itself and glycine in the brain when its plasma concentrations increase. Option D: It may inhibit the action of pepsin by subsequent increases in pH. " B 5280443 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can bind to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus, thus inhibiting the firing rate of 5-HT-containing neurons in the dorsal raphe. Option B: It inhibits the expression of involucrin (hINV), a marker of keratinocyte differentiation, via a protein kinase Cdelta (PKCdelta), Ras, MEKK1, MEK3 cascade that increases AP1 factor level and AP1 factor binding to DNA elements in the hINV promoter. Option C: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option D: It blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors, depresses the release of hypothalamic and hypophyseal hormones, and affects basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. " B 3365 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It increases cellular permeability causing leakage of cellular contents by inhibiting the synthesis of ergosterol, an essential component of the fungal cell membrane. Option B: It can inhibit ergosterol synthesis, resulting in increased cellular permeability causing leakage of cellular contents. Option C: It inhibits ergosterol synthesis, resulting in increased cellular permeability and leakage of cellular contents. Option D: It increases large intestinal motility and inhibits large intestine fluid/electrolyte absorption. " A 3261 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C2=NN=CN2C3=C(C=C(C=C3)Cl)C(=N1)C4=CC=CC=C4 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors, depresses the release of hypothalamic and hypophyseal hormones, and affects basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. Option B: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option C: It inhibits lateral shoot branching, stimulates germination of Striga, and aids in the symbiosis of over 80% of terrestrial plants with fungi at arbuscular mycorrihizae in roots. Option D: It enhances the effects of GABA by increasing GABA affinity for the GABA receptor, as benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors. " D 3386 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. Option B: It promotes insulin sensitivity and the improved uptake of blood glucose via agonism at the peroxisome proliferator-activated receptor-gamma (PPARγ). Option C: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. Option D: It can block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. " A 24404 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: P Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It may cause convulsions after an apparent recovery. Option B: It can cause unexplained hypotension and conduction abnormalities in overdose situations. Option C: It causes significant discomfort throughout the day and requires frequent treatment with eye drops. Option D: It causes overexcitation, paralysis, and death in insects. " A 104730 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Co] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option B: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option C: It causes respiratory effects such as respiratory irritation, wheezing, asthma, pneumonia, and fibrosis with chronic (long-term) inhalation exposure. Option D: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. " C 5862 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@@H](C(=O)O)N)S Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It improves cardiac function, reduces afterload, increases cardiac output, and prevents ventricular hypertrophy and remodeling. Option B: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and receptor blockage at high levels, leading to paralysis and death. Option C: It can effectively and safely increase lumbar and hip bone mineral density in osteoporotic patients who also received vitamin D3 supplementation. Option D: It enhances the effect of topically applied silver, tin, and zinc salts in preventing dental cavities. " D 5161 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)C(=O)OC2=CC=CC=C2C(=O)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has shown similar efficacy to theophylline in the treatment of asthma, but with significantly fewer side effects in animal and human studies. Option B: It causes no greater fecal gastrointestinal blood loss than placebo, in contrast to aspirin. Option C: It is known to exacerbate psychopathological symptoms in schizophrenic patients, but there is no evidence of similar effects in healthy subjects. Option D: It has been associated with fever, mild jaundice and clinically apparent liver injury in up to 2% of treated patients. " B 31736 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)COC(=O)C2=CC=CC=C2C(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option B: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option C: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option D: It produces anti-androgenic effects in animals by reducing testosterone production and, at very high levels, reducing estrogen production, possibly by inhibiting testicular and ovarian steroidogenesis. " D 5388962 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can decrease cell membrane integrity to realize its physiologic effect. Option B: It exhibits decreased blood pressure as its physiologic effect. Option C: It exhibits decreased sympathetic activity as its physiologic effect. Option D: It can decrease blood pressure to realize its physiologic effect. " B 3278 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits increased cellular death as its physiologic effect. Option B: It exhibits increased diuresis at the loop of Henle as its physiologic effect. Option C: It exhibits increased diuresis as its physiologic effect. Option D: It can exhibit increased diuresis as its physiologic effect. " B 9854073 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)OC)C)OC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits increased cellular death as its physiologic effect. Option B: It exhibits decreased mitosis and microtubule inhibition as its physiologic effects. Option C: It exhibits microtubule inhibition as its physiologic effect. Option D: It exhibits decreased platelet production as its physiologic effect. " C 115237 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=O)N2CCCC(C2=N1)O)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It down-regulates cerebral cortical β-adrenergic receptors and sensitizes post-synaptic serotonergic receptors with chronic use, similar to TCAs. Option B: It can exhibit antagonist effects at alpha 1 and alpha 2 adrenergic receptors and H1 histaminergic receptors. Option C: It down-regulates cerebral cortical β-adrenergic receptors and sensitizes post-synaptic serotonergic receptors with chronic use. Option D: It can down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. " B 6344 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can exhibit nervous system effects including decreased visual, auditory, and motor functions. Option B: It causes mucous membrane and eye irritation, and gastrointestinal effects. Option C: It causes central nervous system depression and irritation of the eyes and mucous membranes upon acute exposure in humans. Option D: It causes severe respiratory tract irritation and inflammation in humans upon acute inhalation exposure. " A 644019 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC1=CC(=C(C(=C1)O)[C@@H]2C=C(CC[C@H]2C(=C)C)C)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can stimulate ASM contraction by activating M3 muscarinic receptors. Option B: It can exhibit effects mediated through cannabinoid receptors 1 and 2 (CB1 and CB2). Option C: It primarily affects mu-type opioid receptors, which function as modulators of synaptic transmission via G-proteins. Option D: It promotes insulin sensitivity and the improved uptake of blood glucose via agonism at the peroxisome proliferator-activated receptor-gamma (PPARγ). " B 5280360 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1C/C=C\\CCCC(=O)O)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can effectively and safely increase lumbar and hip bone mineral density in osteoporotic patients who also received vitamin D3 supplementation. Option B: It can stimulate osteoblasts to release factors which stimulate bone resorption by osteoclasts. Option C: It decreases serum calcium by inhibiting tumor-induced bone resorption and reducing calcium flow from the resorbing bone into the blood in malignancy-related hypercalcemia. Option D: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and receptor blockage at high levels, leading to paralysis and death. " B 6129 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC(=O)OC1=CC=CC2=CC=CC=C21 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can inhibit the hydrolysis of acetylcholine released from functioning cholinergic neurons. Option B: Its health effects are consistent with those of other organophosphates and are the result of cholinesterase inhibition. Option C: It can cause cholinesterase inhibition and neurological effects. Option D: It induces the effect of inhibiting the enzyme acetylcholinesterase in peripheral nerve endings. " C 71 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(=O)C(=O)O)CC(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes significant discomfort throughout the day and requires frequent treatment with eye drops. Option B: It causes severe respiratory tract irritation and inflammation in humans upon acute inhalation exposure. Option C: It causes overexcitation, paralysis, and death in insects. Option D: It can cause mental retardation, hypotonia, or seizures. " D 5505 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can increase peripheral glucose utilization, decrease hepatic gluconeogenesis, and may increase the number and sensitivity of insulin receptors. Option B: It increases peripheral glucose utilization, decreases hepatic gluconeogenesis, and may increase the number and sensitivity of insulin receptors. Option C: By inhibiting the endogenous production of cholesterol within the liver, it lowers abnormal cholesterol and lipid levels and ultimately reduces the risk of cardiovascular disease. Option D: It decreases hepatic cholesterol levels, increases hepatic uptake of cholesterol, and reduces plasma cholesterol levels. " A 54680692 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can inhibit vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). Option B: It inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). Option C: It prevents carboxylation of vitamin K-dependent clotting factors and interferes with coagulation. Option D: It can effectively and safely increase lumbar and hip bone mineral density in osteoporotic patients who also received vitamin D3 supplementation. " A 2564 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCOC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can antagonize the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. Option B: It antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. Option C: It can mimic the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain transmission. Option D: It primarily affects OP3 receptors, which function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. " A 3226 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(OC(F)F)(F)F)(F)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits local anesthesia. Option B: It can exhibit general anesthesia effects. Option C: It can induce general anesthesia. Option D: It exhibits general anesthesia. " B 802 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=CN2)CC(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can be toxic after oxidative decarboxylation and may conjugate with DNA bases and protein thiols. Option B: It has a decreased incidence of adverse effects compared to high dose monotherapy in the treatment of moderate hypertension. Option C: It can improve efficacy and reduce toxic side effects of higher doses of 5-FU when pre-administered with uridine. Option D: It allows for better treatment outcomes and a decreased side effect profile by increasing systemic exposure of anti-retrovirals (ARVs) without increasing dosage. " A 3715 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can reduce corneal sensitivity and increase the risk of superficial punctate keratitis and subjective symptoms of discomfort. Option B: It can cause elevated blood levels of ammonia, leading to neurologic problems, cerebral edema, coma, and death in a rare genetic disorder. Option C: It has serious side effects including allergic reactions, irregular heartbeats, and low or high blood pressure, as well as less serious side effects such as headaches, insomnia, and impotence. Option D: It can lower blood pressure and reduce the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. " A 4409 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)CCC1=CC2=C(C=C1)C=C(C=C2)OC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has a higher incidence of severe adverse effects compared to warfarin. Option B: It has a very high potency and a comparable side effect profile to the parent compound. Option C: It has a comparatively favorable adverse effect profile. Option D: It can produce significant adverse effects in the GI tract. " D 5526 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC(CCC1CN)C(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can exhibit decreased fibrinolysis effects. Option B: It exhibits decreased fibrinolysis. Option C: It can cause decreased blood pressure. Option D: It exhibits decreased blood pressure. " A 4932 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits central nervous system stimulation. Option B: It exhibits central nervous system stimulation as its physiologic effect. Option C: It can stimulate the central nervous system. Option D: It is particularly effective in ventricular arrhythmias. " D 3080 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(CS)S)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It results in a buildup of toxic substances that are responsible for numerous adverse side effects. Option B: It can produce significant adverse effects in the GI tract. Option C: It has a variety of adverse effects. Option D: It has a comparatively favorable adverse effect profile. " C 446220 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1[C@H]2CC[C@@H]1[C@H]([C@H](C2)OC(=O)C3=CC=CC=C3)C(=O)OC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It probably reflects an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake. Option B: It has reinforcing effects and inhibits dopamine uptake. Option C: It primarily affects mu-type opioid receptors, which function as modulators of synaptic transmission via G-proteins. Option D: It can increase norepinephrine and dopamine efflux throughout the brain, impair cognition, and have locomotor-activating effects. " B 1978 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(=O)NC1=CC(=C(C=C1)OCC(CNC(C)C)O)C(=O)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has stabilizing and quinidine-like effects on cardiac rhythm and weak inherent sympathomimetic action. Option B: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and blockage of the receptors at high levels, leading to paralysis and death. Option C: It has therapeutic effects similar to salicylates, but lacks anti-inflammatory, antiplatelet, and gastric ulcerative effects. Option D: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and receptor blockage at high levels, leading to paralysis and death. " A 38033 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC(=C1)Cl)C2=C(C=CC(=C2)Cl)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can exhibit centrally-mediated muscle relaxation as its physiologic effect. Option B: It exhibits centrally-mediated muscle relaxation. Option C: It causes centrally-mediated muscle relaxation. Option D: It causes harmful health effects and bioaccumulates. " D 3883 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCC(F)(F)F Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause metabolic acidosis, intracranial hemorrhage, feeding difficulties, and significant neurological symptoms. Option B: It improves cardiac function, reduces afterload, increases cardiac output, and prevents ventricular hypertrophy and remodeling. Option C: It inhibits gastric acid secretion. Option D: It can decrease motility of the gastrointestinal and urinary tracts and inhibit gastric acid secretion. " C 5463984 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC2=CC=CC=C2N(C(=O)[C@H]1N[C@@H](CCC3=CC=CC=C3)C(=O)O)CC(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits decreased blood pressure. Option B: It can cause decreased blood pressure. Option C: It exhibits decreased blood pressure as its physiologic effect. Option D: It decreases blood pressure. " D 40326 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C(C1C(=O)OCC2=CC(=CC=C2)OC3=CC=CC=C3)C=C(Cl)Cl)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes overexcitation, paralysis, and death in insects. Option B: It causes severe respiratory tract irritation and inflammation in humans upon acute inhalation exposure. Option C: It causes delayed repolarization and paralysis of pests. Option D: It causes mucous membrane and eye irritation, and gastrointestinal effects. " C 1145 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+](C)(C)[O-] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It raises blood sugar through activation of hepatic receptors, stimulating glycogenolysis and the release of glucose. Option B: It alters cholesterol metabolism, increases deposition of cholesterol within peripheral cells, and decreases removal of cholesterol from peripheral cells. Option C: It improves cardiac function, reduces afterload, increases cardiac output, and prevents ventricular hypertrophy and remodeling. Option D: It decreases hepatic cholesterol levels, increases hepatic uptake of cholesterol, and reduces plasma cholesterol levels. " B 3341 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CNCC(C2=CC(=C(C(=C21)Cl)O)O)C3=CC=C(C=C3)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It lowers blood pressure through arteriolar vasodilation. Option B: It can cause arteriolar vasodilation. Option C: It can cause decreased GnRH secretion. Option D: It exhibits arteriolar vasodilation. " A 54746 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@H]2[C@@H](CC3=CNC4=CC=CC2=C34)N(C1)CC=C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It decreases systemic vascular resistance by blocking the vasoconstrictor and aldosterone-stimulating effects of angiotensin II. Option B: It promotes insulin sensitivity and the improved uptake of blood glucose via agonism at the peroxisome proliferator-activated receptor-gamma (PPARγ). Option C: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. Option D: It inhibits adenylyl cyclase, decreases intracellular cAMP concentrations, and blocks IP3-dependent release of Ca2+ from intracellular stores. " D 135398559 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@@H](N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has a lower incidence of metabolic adverse effects compared to other medications in the same class. Option B: It has a high rate of efficacy in many types of infection and no severe side effects have been noted. Option C: It causes a deficiency of coenzymes and a buildup of toxic substances responsible for numerous adverse side effects. Option D: It results in a buildup of toxic substances that are responsible for numerous adverse side effects. " C 7964 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes central nervous system depression and irritation of the eyes and mucous membranes upon acute exposure in humans. Option B: It produces narcosis, restlessness, tremors, and muscle spasms. Option C: It causes sustained tremors, convulsions, and death in the central nervous system. Option D: It causes mucous membrane and eye irritation, and gastrointestinal effects. " B 54260 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C)(C)C1=CC=C(C=C1)CC(C)CN2C[C@H](O[C@H](C2)C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It increases cellular permeability causing leakage of cellular contents by inhibiting the synthesis of ergosterol, an essential component of the fungal cell membrane. Option B: It depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. Option C: It can inhibit ergosterol synthesis, resulting in increased cellular permeability causing leakage of cellular contents. Option D: It inhibits ergosterol synthesis, resulting in increased cellular permeability and leakage of cellular contents. " B 3308 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC1=C2C(=CC=C1)C3=C(N2)C(OCC3)(CC)CC(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It inhibits prostaglandin synthesis. Option B: It can increase prostaglandin activity to realize its physiologic effect. Option C: It decreases platelet aggregation. Option D: It decreases prostaglandin production and platelet aggregation. " A 32518 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCCN1CC(OC(C1)C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It inhibits lateral shoot branching, stimulates germination of Striga, and aids in the symbiosis of over 80% of terrestrial plants with fungi at arbuscular mycorrihizae in roots. Option B: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option C: It blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors, depresses the release of hypothalamic and hypophyseal hormones, and affects basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. Option D: It can cause edemas, hemorrhages, hematomas, abnormal development of the brain, abnormal development of the visceral cranium, abnormal development of the genitourinary system, decreased size of pelvic bones, decreased size of shoulder girdle, decreased size of front and hind limbs, etc. " D 38081 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CC=C1NC2=C(C=CC=N2)C(=O)O)C(F)(F)F Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exerts analgesic and antipyretic effects. Option B: It induces cell cycle arrest and apoptosis in various cancer cells. Option C: It induces apoptosis and displays antitumour effects. Option D: It causes interstrand linkages in DNA resulting in cell apoptosis. " A 213021 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=NC#N)N(C)CC1=CN=C(C=C1)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and blockage of the receptors at high levels, leading to paralysis and death. Option B: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option C: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and receptor blockage at high levels, leading to paralysis and death. Option D: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. " C 4926 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is associated with transient and usually mild elevations in serum aminotransferase during therapy and to rare instances of self-limited, clinically apparent idiosyncratic acute liver injury as well as to cases of reactivation of hepatitis B in susceptible individuals. Option B: It blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors, depresses the release of hypothalamic and hypophyseal hormones, and affects basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. Option C: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option D: It does not block dopamine within the tubero-infundibular tract, resulting in a lower incidence of hyperprolactinemia compared to typical antipsychotic agents or risperidone. " D 1993 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C[N+](C)(C)C)OC(=O)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is the prototypical agonist at nicotinic cholinergic receptors, dramatically stimulating neurons and ultimately blocking synaptic transmission. Option B: It dramatically stimulates neurons and ultimately blocks synaptic transmission as the prototypical agonist at nicotinic cholinergic receptors. Option C: It causes longstanding nicotinic receptor activation, resulting in spastic paralysis of susceptible nematodes (worms). Option D: It can stimulate ASM contraction by activating M3 muscarinic receptors. " D 23978 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Cu] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can be associated with mild serum enzyme elevations and has been linked to rare instances of clinically apparent liver injury. Option B: It can be poisonous or even fatal to organisms in sufficient amounts. Option C: It is associated with transient serum enzyme elevations during therapy and with rare instances of acute liver injury. Option D: It is relatively innocuous, yet effective, and systemic side effects have not been observed. " B 213039 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CN(C[C@H]([C@H](CC1=CC=CC=C1)NC(=O)O[C@H]2CO[C@@H]3[C@H]2CCO3)O)S(=O)(=O)C4=CC=C(C=C4)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It may result in an exacerbation of the underlying chronic hepatitis B or C in HBV or HCV coinfected patients. Option B: It may result in an exacerbation of the underlying chronic hepatitis B or C in HBV or HCV coinfected patients receiving highly active antiretroviral therapy. Option C: It may exacerbate underlying chronic hepatitis B or C in coinfected patients. Option D: It may result in an exacerbation of the underlying chronic hepatitis B or C. " B 6251 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits decreased blood pressure as its physiologic effect. Option B: It can exhibit increased diuresis as its physiologic effect. Option C: It exhibits increased diuresis as its physiologic effect. Option D: It exhibits increased cellular death as its physiologic effect. " C 15531 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1Br)O)Br)C#N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can exhibit general anesthesia effects. Option B: It can induce general anesthesia. Option C: It interferes with an enzyme pathway. Option D: It works by inhibiting photosynthesis. " D 27125 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1[C@H]([C@H]([C@@H]2O)O)O)CCC4=C3C=CC(=C4)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is more potent and safer than ethinylestradiol, reducing the environmental accumulation of unwanted endocrine disrupting chemicals and harmful epigenetic effects. Option B: It can have effects of ionizing and non-ionizing radiation, air pollution and natural toxic gases such as ozone, and chemicals and toxins including oxidizing disinfectants. Option C: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option D: It produces anti-androgenic effects in animals by reducing testosterone production and, at very high levels, reducing estrogen production, possibly by inhibiting testicular and ovarian steroidogenesis. " A 129211 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC1=CC=CC=C1OCCN[C@H](C)CC2=CC(=C(C=C2)OC)S(=O)(=O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking cortical and limbic arousal following stimulation of the reticular pathways. Option B: By inhibiting the endogenous production of cholesterol within the liver, it lowers abnormal cholesterol and lipid levels and ultimately reduces the risk of cardiovascular disease. Option C: It leads to relaxation of smooth muscle in the prostate and detrusor muscles in the bladder, improving urinary flow. Option D: It can increase cyclic AMP, which is associated with relaxation of bronchial smooth muscle and inhibition of release of hypersensitivity mediators from mast cells in the lungs. " C 2972 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=O)C=CN1C)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes clinically apparent acute liver injury and rare instances of death. Option B: It is associated with transient serum enzyme elevations during therapy and with rare instances of acute liver injury. Option C: It has a low rate of transient serum aminotransferase elevations during therapy and rare instances of clinically apparent liver injury. Option D: It has been linked to mild, transient elevations in serum aminotransferase levels during therapy as well as rare instances of idiosyncratic drug-induced liver disease. " C 121396 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(=O)O)[C@@H](C(=O)O)NC(=O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option B: It is associated with transient and usually mild elevations in serum aminotransferase during therapy and to rare instances of self-limited, clinically apparent idiosyncratic acute liver injury as well as to cases of reactivation of hepatitis B in susceptible individuals. Option C: It can cause transient serum enzyme elevations during therapy, rare cases of cholestatic hepatitis, instances of nodular regenerative hyperplasia, and sinusoidal obstruction syndrome when given in high doses. Option D: It can cause elevated blood levels of ammonia, leading to neurologic problems, cerebral edema, coma, and death in a rare genetic disorder. " D 7261 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)N)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause respiratory problems, stomach gas, rise in blood pressure, dizziness, convulsions, fainting, and coma. Option B: It can cause irritation of the eyes, cough, wheezing, asthmatic symptoms, pulmonary edema, pneumonia, dizziness, weakness, headache, and chest pains. Option C: It is associated with numerous side effects including dizziness, drowsiness, nausea, vomiting, diarrhea, headache, aphasia, lack of concentration, psychomotor retardation, speech disturbances, ataxia, depression, and hyponatremia. Option D: It can cause mental retardation, macrocephaly with cerebral atrophy, hypotonia, seizures, and involuntary movements in patients who have excess accumulation of D-2-hydroxyglutaric acid in the urine. " A 5826 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](CC1=CC=CC=C1)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It stimulates the central nervous system. Option B: It exhibits central nervous system stimulation. Option C: It can stimulate the central nervous system. Option D: It exhibits central nervous system stimulation as its physiologic effect. " D 4679 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C(=NC=C1)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC(F)F)OC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It prevents the final step in gastric acid production by covalently binding to sulfhydryl groups of cysteines found on the (H+, K+)-ATPase enzyme at the secretory surface of gastric parietal cell. Option B: It causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, inhibiting its polymerization or assembly into microtubules. Option C: It increases secretion by the exocrine glands, and produces contraction of the iris sphincter muscle and ciliary muscle (when given topically to the eyes) by mainly stimulating muscarinic receptors. Option D: It decreases systemic vascular resistance by blocking the vasoconstrictor and aldosterone-stimulating effects of angiotensin II. " A 4205 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CCN2C(C1)C3=CC=CC=C3CC4=C2N=CC=C4 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes clinically apparent acute liver injury and rare instances of death. Option B: It is associated with transient serum enzyme elevations during therapy and with rare instances of acute liver injury. Option C: The effects of this drug may be observed as early as 1 week after beginning therapy. Option D: Limited information is available on the acute and chronic effects of this molecule in humans. " C 8141 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause increased cellular death. Option B: It can cause joint pain. Option C: It can cause blindness. Option D: It may lead to breathing difficulty. " D 1140 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors, depresses the release of hypothalamic and hypophyseal hormones, and affects basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. Option B: It inhibits lateral shoot branching, stimulates germination of Striga, and aids in the symbiosis of over 80% of terrestrial plants with fungi at arbuscular mycorrihizae in roots. Option C: It can potentiate the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways. Option D: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. " D 11504295 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(CC1=CC=C(C=C1)OC)NC[C@@H](C2=C3C(=CC(=C2)O)NC(=O)CO3)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can induce vasodilation of arterioles and large coronary arteries by activating potassium channels. Option B: It leads to relaxation of smooth muscle in the prostate and detrusor muscles in the bladder, improving urinary flow. Option C: It stimulates mucus secretion in the lung and produces contractions of nonvascular and some vascular smooth muscle. Option D: It induces bronchodilation by relaxation of airway smooth muscles. " D 10531 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@]1(C(=O)N2[C@H](C(=O)N3CCC[C@H]3[C@@]2(O1)O)CC4=CC=CC=C4)NC(=O)[C@@H]5C[C@H]6[C@@H](CC7=CNC8=CC=CC6=C78)N(C5)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: Its use has largely been supplanted by triptans in current therapy due to the class's greater selectivity and more favourable side effect profile. Option B: It has a minimal side effect profile and uncomplicated metabolic profile, making it suitable for the treatment of mycotic outbreaks such as vaginal yeast infections and athlete's foot. Option C: It does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. Option D: It is known to exacerbate psychopathological symptoms in schizophrenic patients, but there is no evidence of similar effects in healthy subjects. " A 3337 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC(C)CC1=CC(=CC=C1)C(F)(F)F Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and receptor blockage at high levels, leading to paralysis and death. Option B: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and blockage of the receptors at high levels, leading to paralysis and death. Option C: It can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. Option D: It is associated with seizures, delayed development, and neurocognitive impairment. " D 446541 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C2COC(=O)C2=C(C(=C1OC)C/C=C(\\C)/CCC(=O)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is associated with transient serum enzyme elevations during therapy and with rare instances of acute liver injury. Option B: It is associated with transient serum aminotransferase elevations during therapy and with rare instances of clinically apparent liver injury. Option C: It can be associated with mild serum enzyme elevations and has been linked to rare instances of clinically apparent liver injury. Option D: It causes clinically apparent acute liver injury and rare instances of death. " C 5994 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It directly stimulates the uterine muscle to increase force and frequency of contractions. Option B: It causes centrally-mediated muscle relaxation. Option C: It causes contraction of the uterus. Option D: It decreases contractility of the uterine smooth muscle. " D 2160 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. Option B: It can down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. Option C: It down-regulates cerebral cortical β-adrenergic receptors and sensitizes post-synaptic serotonergic receptors with chronic use. Option D: It down-regulates cerebral cortical β-adrenergic receptors and sensitizes post-synaptic serotonergic receptors with chronic use, similar to TCAs. " C 2576 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(C)(COC(=O)N)COC(=O)NC(C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits centrally-mediated muscle relaxation. Option B: It causes centrally-mediated muscle relaxation. Option C: It can exhibit centrally-mediated muscle relaxation as its physiologic effect. Option D: It exhibits decreased sympathetic activity as its physiologic effect. " A 743 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(=O)O)CC(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It leads to nonspecific developmental delay, hypotonia, and macrocephaly with cerebral atrophy of prenatal onset. Option B: It can cause noncirrhotic portal hypertension due to hepatoportal sclerosis and nodular regenerative hyperplasia with long term therapy. Option C: It has been associated with development of fatty liver, steatohepatitis, cirrhosis, and rare instances of clinically apparent acute liver injury with long term therapy. Option D: It can cause transient serum enzyme elevations during therapy, rare cases of cholestatic hepatitis, instances of nodular regenerative hyperplasia, and sinusoidal obstruction syndrome when given in high doses. " A 992 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=C(C(=C(C(=C1Cl)Cl)Cl)Cl)Cl)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can affect the lungs, gastrointestinal system, blood, liver, kidneys, central nervous system, and eyes. Option B: It can affect the lungs, liver, kidneys, and heart. Option C: Chronic (long-term) exposure to it by inhalation in humans has resulted in effects on the respiratory tract, blood, kidney, liver, immune system, eyes, nose, and skin. Option D: It affects the central nervous system, blood, respiratory system, eyes, and skin. " C 72287 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](CN1C2=CC=CC=C2SC3=C1C=C(C=C3)OC)CN(C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. Option B: It has histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. Option C: It can mimic the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain transmission. Option D: It can antagonize the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. " B 4497 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction by inhibiting the influx of calcium in smooth muscle cells. Option B: It can increase cyclic AMP, which is associated with relaxation of bronchial smooth muscle and inhibition of release of hypersensitivity mediators from mast cells in the lungs. Option C: By inhibiting the endogenous production of cholesterol within the liver, it lowers abnormal cholesterol and lipid levels and ultimately reduces the risk of cardiovascular disease. Option D: It decreases serum calcium by inhibiting tumor-induced bone resorption and reducing calcium flow from the resorbing bone into the blood in malignancy-related hypercalcemia. " A 71158 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)NCCCS(=O)(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option B: It can cause elevated blood levels of ammonia, leading to neurologic problems, cerebral edema, coma, and death in a rare genetic disorder. Option C: It has serious side effects including allergic reactions, irregular heartbeats, and low or high blood pressure, as well as less serious side effects such as headaches, insomnia, and impotence. Option D: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. " C 935 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Ni] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has serious side effects including allergic reactions, irregular heartbeats, and low or high blood pressure, as well as less serious side effects such as headaches, insomnia, and impotence. Option B: It can cause nickel dermatitis, consisting of itching of the fingers, hands, and forearms. Option C: It causes mild central nervous system effects, including dizziness, giddiness, slight nausea, and headache. Option D: It narrows blood vessels in the brain, stops pain signals from being sent to the brain, and stops the release of certain natural substances that cause pain, nausea, and other symptoms of migraine. " B 444031 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(C[C@@H]1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It shows relaxative effects on isolated guinea pig tracheal spirals in vitro. Option B: It can cause dermatitis in humans with acute (short-term) exposure. Option C: It decreases the serum p-cresol concentration in uremic patients. Option D: It reduces the urgency to urinate and should not be used in people with urinary retention. " D 5656 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking cortical and limbic arousal following stimulation of the reticular pathways. Option B: It can potentiate the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways. Option C: It works by blocking the transporter reuptake proteins for key neurotransmitters affecting mood, leaving more active neurotransmitter in the synapse. Option D: It increases secretion by the exocrine glands, and produces contraction of the iris sphincter muscle and ciliary muscle (when given topically to the eyes) by mainly stimulating muscarinic receptors. " C 6914 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1Cl)O)Cl)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: Limited information is available on the acute and chronic effects of this molecule in humans. Option B: Acute exposure to this molecule affects the blood with clinical signs of central nervous system depression. Option C: It can cause increased amount of this molecule in the blood of premature infants, which is marked by decreased motor activity, lethargy and poor feeding. Option D: Excess of this molecule in the blood may contribute to mental retardation. " A 5362420 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C2=CC3=NC(=CC4=C(C(=C(N4)C=C5[C@@]6([C@@H](C(=CC=C6C(=N5)C=C1N2)C(=O)OC)C(=O)OC)C)C)CCC(=O)OC)C(=C3C)CCC(=O)O)C=C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option B: It can cause a decrease in systemic arterial blood pressure and systemic vascular resistance without a substantial reduction in resting heart rate, cardiac output, or stroke volume, apparently because of its combined α- and β-adrenergic blocking activity. Option C: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option D: It accumulates in abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 nm in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels. " D 7242 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: Acute inhalation exposure to it can cause irritation of the respiratory tract and eye irritation in humans. Option B: It can have effects on the liver and central nervous system from oral exposure in animal studies. Option C: Acute exposure to this molecule affects the blood with clinical signs of central nervous system depression. Option D: It causes central nervous system depression and irritation of the eyes and mucous membranes upon acute exposure in humans. " C 657181 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Option B: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. Option C: It promotes insulin sensitivity and the improved uptake of blood glucose via agonism at the peroxisome proliferator-activated receptor-gamma (PPARγ). Option D: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. " A 175805 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN1CCCC[C@H]1C(=O)NC2=C(C=CC=C2C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits local anesthesia as its physiologic effect. Option B: It exhibits decreased sympathetic activity as its physiologic effect. Option C: It exhibits the physiologic effect of local anesthesia. Option D: It can exhibit general anesthesia as its physiologic effect. " C 2249 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(COC1=CC=C(C=C1)CC(=O)N)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: If these receptors are blocked, it can result in bronchospasm with serious lack of oxygen in the body. Option B: It has shown similar efficacy to theophylline in the treatment of asthma, but with significantly fewer side effects in animal and human studies. Option C: It causes no greater fecal gastrointestinal blood loss than placebo, in contrast to aspirin. Option D: It does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. " A 5282452 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC1C2=NC3=CC=CC=C3C(=C2/C=C/[C@H](C[C@H](CC(=O)O)O)O)C4=CC=C(C=C4)F Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can potentiate the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways. Option B: By inhibiting the endogenous production of cholesterol within the liver, it lowers abnormal cholesterol and lipid levels and ultimately reduces the risk of cardiovascular disease. Option C: It can increase cyclic AMP, which is associated with relaxation of bronchial smooth muscle and inhibition of release of hypersensitivity mediators from mast cells in the lungs. Option D: It increases secretion by the exocrine glands, and produces contraction of the iris sphincter muscle and ciliary muscle (when given topically to the eyes) by mainly stimulating muscarinic receptors. " B 2724385 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5C[C@H]([C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)O)C)C)C)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has positive inotropic and negative chronotropic activity. Option B: It has minimal side effects, with the most common being headache and fatigue. Option C: It has long-lasting effects and can be administered once a day. Option D: It has few side effects and is reported to be safe and effective. " A 5284569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3C(=O)CC4 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It promotes insulin sensitivity and the improved uptake of blood glucose via agonism at the peroxisome proliferator-activated receptor-gamma (PPARγ). Option B: It primarily affects OP3 receptors, which function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Option C: It potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking cortical and limbic arousal following stimulation of the reticular pathways. Option D: It primarily affects mu-type opioid receptors, which function as modulators of synaptic transmission via G-proteins. " B 24478 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OS(=O)(=S)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: When administered 6 hours after cisplatin chemotherapy, it leads to a lower incidence of cisplatin-induced hearing loss among children without affecting its effectiveness. Option B: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option C: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option D: It can cause transient serum enzyme elevations during therapy, rare cases of cholestatic hepatitis, instances of nodular regenerative hyperplasia, and sinusoidal obstruction syndrome when given in high doses. " A 56640146 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)C1=CC(=CC(=C1OC)C2=CC3=C(C=C2)C=C(C=C3)NS(=O)(=O)C)N4C=CC(=O)NC4=O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. Option B: Its use has largely been supplanted by triptans in current therapy due to the class's greater selectivity and more favourable side effect profile. Option C: It can exhibit high selectivity to FLT3 preventing the c-Kit-driven myelosuppression observed in other therapies. Option D: It can induce a conformational change in NS5B and render the polymerase unable to elongate viral RNA. " D 7029 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)C(C)C(=O)C1=CC=CC=C1 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can suppress appetite. Option B: It may lead to breathing difficulty. Option C: It can suppress hunger signals and appetite. Option D: It suppresses hunger signals and appetite. " C 6564 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CCl)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It affects the central nervous system, blood, respiratory system, eyes, and skin. Option B: It can affect the lungs, gastrointestinal system, blood, liver, kidneys, central nervous system, and eyes. Option C: Chronic (long-term) exposure to it by inhalation in humans has resulted in effects on the respiratory tract, blood, kidney, liver, immune system, eyes, nose, and skin. Option D: It can affect the lungs, liver, kidneys, and heart. " B 4059 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1OCC(CO)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits central nervous system depression. Option B: It can produce transient muscle relaxation and paralysis via central nervous system depression. Option C: It exhibits central nervous system stimulation as its physiologic effect. Option D: It exhibits central nervous system depression and decreased central nervous system organized electrical activity. " B 4078 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It increases diuresis. Option B: It can depress hypothalamic centers. Option C: It can increase diuresis. Option D: It can exhibit increased diuresis. " B 6214 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)(Cl)Cl)(Cl)(Cl)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits central nervous system stimulation. Option B: It exhibits central nervous system stimulation as its physiologic effect. Option C: It stimulates the central nervous system. Option D: It primarily acts as a central nervous system depressant. " D 54738 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C1(C(=O)NC(=N1)C2=C(C=CC=N2)C(=O)O)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can exhibit general anesthesia effects. Option B: It exhibits general anesthesia. Option C: It interferes with an enzyme pathway. Option D: It can induce general anesthesia. " C 6337 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can affect the lungs, gastrointestinal system, blood, liver, kidneys, central nervous system, and eyes. Option B: It can affect the lungs, liver, kidneys, and heart. Option C: It has liver, kidney, spleen, and central nervous system (CNS) effects in chronic (long-term) animal studies. Option D: Chronic (long-term) exposure to it by inhalation in humans has resulted in effects on the respiratory tract, blood, kidney, liver, immune system, eyes, nose, and skin. " B 3742 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)N(C)C1=C(C(=C(C(=C1I)C(=O)NCC(=O)NC2=C(C(=C(C(=C2I)C(=O)O)I)C(=O)NCCO)I)I)C(=O)NC)I Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has few side effects and is reported to be safe and effective. Option B: It has low osmolarity and is associated with fewer side effects. Option C: It has minimal side effects, with the most common being headache and fatigue. Option D: It has a very high potency and a comparable side effect profile to the parent compound. " B 3372 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors, depresses the release of hypothalamic and hypophyseal hormones, and affects basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. Option B: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option C: It can potentiate the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways. Option D: It inhibits lateral shoot branching, stimulates germination of Striga, and aids in the symbiosis of over 80% of terrestrial plants with fungi at arbuscular mycorrihizae in roots. " A 23976 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Cr] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: By inhibiting the endogenous production of cholesterol within the liver, it lowers abnormal cholesterol and lipid levels and ultimately reduces the risk of cardiovascular disease. Option B: It can increase peripheral glucose utilization, decrease hepatic gluconeogenesis, and may increase the number and sensitivity of insulin receptors. Option C: It may lead to apoptosis, premature terminal growth arrest, or neoplastic transformation. Option D: It increases peripheral glucose utilization, decreases hepatic gluconeogenesis, and may increase the number and sensitivity of insulin receptors. " C 3007 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CC1=CC=CC=C1)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits central nervous system stimulation. Option B: It exhibits central nervous system depression. Option C: It stimulates the central nervous system. Option D: It can stimulate the central nervous system. " A 2678 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It does not cause drowsiness or anticholinergic side effects. Option B: It has good tolerance, lack of toxicity, and no dose-limiting side effects. Option C: It does not cause drowsiness because it does not readily enter the central nervous system. Option D: It is irritant but produces no acute systemic effects and has no demonstrable genotoxic potential. " A 54675776 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@]1([C@H]2C[C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can bind RNA in bacterial ribosomes and inhibit protein synthesis. Option B: It can exhibit increased blood flow into the penis, resulting in erection. Option C: It can exert a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. Option D: It may have a narcotic effect in high concentrations. " C 14969 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@H]([C@@](C[C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)[C@H]([C@H](C(=O)N[C@H](C(=O)N[C@H]5C(=O)N[C@@H]7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)[C@H](NC(=O)[C@H]([C@@H](C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)[C@@H](CC(C)C)NC)O)Cl)CO)O)O)(C)N)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can exhibit centrally-mediated muscle relaxation as its physiologic effect. Option B: It can alter bacterial-cell-membrane permeability and RNA synthesis. Option C: It can increase coagulation factor VIII activity and concentration to realize its physiologic effect. Option D: It can increase fibroblast proliferation and accelerate re-epithelialization in wound healing. " B 3286 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)SCSP(=S)(OCC)OCC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is the prototypical agonist at nicotinic cholinergic receptors, dramatically stimulating neurons and ultimately blocking synaptic transmission. Option B: It increases acetylcholine neurotransmission by blocking its breakdown in the synaptic cleft. Option C: It inhibits acetylcholine hydrolysis and enhances cholinergic function through the accumulation of acetylcholine at cholinergic synapses. Option D: It can affect the nervous systems by inhibiting acetylcholineserases. " D 3639 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can increase diuresis. Option B: It increases diuresis. Option C: It can exhibit increased diuresis as its physiologic effect. Option D: It can exhibit increased diuresis. " D 1110 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(=O)O)C(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause episodes of epidermal necrosis without significant long-term effects and post-sclerosis pigmentation that resolved within a few months. Option B: It can cause noncirrhotic portal hypertension due to hepatoportal sclerosis and nodular regenerative hyperplasia with long term therapy. Option C: It can result in epigenetic silencing that affects neuroendocrine differentiation. Option D: It has a minimal side effect profile and uncomplicated metabolic profile, making it suitable for the treatment of mycotic outbreaks such as vaginal yeast infections and athlete's foot. " C 3198 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It inhibits ergosterol synthesis, resulting in increased cellular permeability. Option B: It can inhibit ergosterol synthesis, resulting in increased cellular permeability causing leakage of cellular contents. Option C: It can cause increased cellular permeability causing leakage of cellular contents. Option D: It inhibits ergosterol synthesis, resulting in increased cellular permeability and leakage of cellular contents. " C 2157 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It leads to relaxation of smooth muscle in the prostate and detrusor muscles in the bladder, improving urinary flow. Option B: It can cause inhibition of the action of angiotensin II on vascular smooth muscle, leading to a reduction in arterial blood pressure. Option C: It can result in a decrease in heart rate and vascular resistance. Option D: It can lead to decreased force and rate of heart contractions by blocking beta-adrenergic receptors in the heart. " C 14987 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C[C@@H](C=C2[C@H]1CC3=CNC4=CC=CC2=C34)CO Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is known to exacerbate psychopathological symptoms in schizophrenic patients, but there is no evidence of similar effects in healthy subjects. Option B: It can cause ergotism, a disease causing convulsive and gangrenous symptoms. Option C: It causes debilitating symptoms, significant functional limitations, and a reduced quality of life in patients with tenosynovial giant cell tumors. Option D: It does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. " B 41693 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCC3=CC=CS3)COC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can lead to the accumulation of itself and glycine in the brain when its plasma concentrations increase. Option B: It can stimulate the exchange of GTP for GDP on the G-protein complex. Option C: It can stimulate the exchange of GTP for GDP on the G-protein complex when binding to the opiate. Option D: It stimulates the exchange of GTP for GDP on the G-protein complex. " B 440667 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@@H]([C@@H]1C(=O)C(=O)C(=O)O1)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has similar biological activity as antivirals and neuroprotective effects. Option B: It can be associated with mild serum enzyme elevations and has been linked to rare instances of clinically apparent liver injury. Option C: It exhibits hypotensive and neuroprotective effects. Option D: It causes clinically apparent acute liver injury and rare instances of death. " A 13109 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC(=O)CC[C@H]34 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It inhibits root development and growth. Option B: It inhibits DNA synthesis and causes cell death. Option C: It inhibits DNA synthesis and stops the growth of cancer cells. Option D: It can inhibit ovum fertilization. " D 28780 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCNC(=O)N1C2=CC=CC=C2N=C1NC(=O)OC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can interfere with cell functions, such as meiosis and intracellular transportation, by binding to microtubules. Option B: It causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, inhibiting its polymerization or assembly into microtubules. Option C: It can disrupt (depolymerize) microtubules, blocking anisotropic growth of plant cells. Option D: It exhibits decreased mitosis and microtubule inhibition as its physiologic effects. " A 4633 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOC1=C(C=CC(=C1)C(=O)OCCN(CC)CC)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can lead to the accumulation of itself and glycine in the brain when its plasma concentrations increase. Option B: It inhibits DNA synthesis and stops the growth of cancer cells. Option C: It may inhibit the action of pepsin by subsequent increases in pH. Option D: It can reversibly stabilize the neuronal membrane by binding to sodium channels. " D 54841 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1O[C@H](CCNC)C2=CC=CC=C2 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is known to exacerbate psychopathological symptoms in schizophrenic patients, but there is no evidence of similar effects in healthy subjects. Option B: It specifically increases NA and DA within the prefrontal cortex, but not in the nucleus accumbens (NA) or striatum. Option C: It can cause noncirrhotic portal hypertension due to hepatoportal sclerosis and nodular regenerative hyperplasia with long term therapy. Option D: It does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. " B 33741 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C[C@H]1CCCC[C@@]1(C2=CC(=CC=C2)OC)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can decrease intracellular cAMP by inhibiting adenylate cyclase. Option B: It can increase peripheral glucose utilization, decrease hepatic gluconeogenesis, and may increase the number and sensitivity of insulin receptors. Option C: It inhibits adenylyl cyclase, decreases intracellular cAMP concentrations, and blocks IP3-dependent release of Ca2+ from intracellular stores. Option D: It increases peripheral glucose utilization, decreases hepatic gluconeogenesis, and may increase the number and sensitivity of insulin receptors. " A 439530 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes debilitating symptoms, significant functional limitations, and a reduced quality of life in patients with tenosynovial giant cell tumors. Option B: It is toxic to both prokaryotic and eukaryotic cells, resulting in significant cell death at appropriate doses. Option C: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option D: It has reproductive effects in women exposed by inhalation to high levels and adverse effects on the developing fetus in animal tests. " B 11519070 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C[N+]2(CCC1(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)CCOCC5=CC=CC=C5 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can open up the airways by preventing bronchoconstriction through blocking the M3 muscarinic receptor. Option B: It produces smooth muscle relaxation and bronchodilation by acting on M3 muscarinic receptors in the airways. Option C: It increases secretion by the exocrine glands, and produces contraction of the iris sphincter muscle and ciliary muscle (when given topically to the eyes) by mainly stimulating muscarinic receptors. Option D: It can increase cyclic AMP, which is associated with relaxation of bronchial smooth muscle and inhibition of release of hypersensitivity mediators from mast cells in the lungs. " A 13192 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCCN=C=O)CCN=C=O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause respiratory effects from chronic inhalation exposure and skin irritation and sensitization from dermal exposure. Option B: It causes central nervous system depression and irritation of the eyes and mucous membranes upon acute exposure in humans. Option C: Acute inhalation exposure to it can cause irritation of the respiratory tract and eye irritation in humans. Option D: It causes severe respiratory tract irritation and inflammation in humans upon acute inhalation exposure. " A 3955 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has shown similar efficacy to theophylline in the treatment of asthma, but with significantly fewer side effects in animal and human studies. Option B: It is associated with a risk for experiencing a range of adverse effects, often life-threatening, if taken for non-therapeutic reasons or at doses higher than the recommended dose. Option C: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option D: It can cause transient serum enzyme elevations during therapy, rare cases of cholestatic hepatitis, instances of nodular regenerative hyperplasia, and sinusoidal obstruction syndrome when given in high doses. " B 25074887 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCNC(=O)N)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC3=CN=CC=C3)NC(=O)[C@@H](CC4=CC=C(C=C4)Cl)NC(=O)[C@@H](CC5=CC6=CC=CC=C6C=C5)NC(=O)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits arteriolar vasodilation. Option B: It lowers blood pressure through arteriolar vasodilation. Option C: It can cause decreased GnRH secretion. Option D: It can cause arteriolar vasodilation. " C 2812 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: By inhibiting the endogenous production of cholesterol within the liver, it lowers abnormal cholesterol and lipid levels and ultimately reduces the risk of cardiovascular disease. Option B: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option C: It has a minimal side effect profile and uncomplicated metabolic profile, making it suitable for the treatment of mycotic outbreaks such as vaginal yeast infections and athlete's foot. Option D: It has therapeutic effects similar to salicylates, but lacks anti-inflammatory, antiplatelet, and gastric ulcerative effects. " C 3000322 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1[C@@H]2CC(C[C@H]1[C@H]3[C@@H]2O3)OC(=O)[C@H](CO)C4=CC=CC=C4 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has dose-dependent adverse effects and was the first drug to be offered commercially as a transdermal delivery system. Option B: It has reproductive effects in women exposed by inhalation to high levels and adverse effects on the developing fetus in animal tests. Option C: It has good tolerance, lack of toxicity, and no dose-limiting side effects. Option D: It has a decreased incidence of adverse effects compared to high dose monotherapy in the treatment of moderate hypertension. " A 60490 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C1=CC2=CC=CC=C2S1)N(C(=O)N)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It decreases prostaglandin production and platelet aggregation. Option B: It can inhibit norepinephrine production and reduce blood pressure. Option C: It can increase norepinephrine activity. Option D: It can decrease leukotriene production. " D 3083544 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](CC1=CC=C(C=C1)OC)NC[C@@H](C2=CC(=C(C=C2)O)NC=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can suppress hunger signals and appetite. Option B: It may lead to breathing difficulty. Option C: It suppresses hunger signals and appetite. Option D: It can relax muscles in the airways to improve breathing. " D 24877 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]P(=O)([O-])OP(=O)([O-])[O-].[O-]P(=O)([O-])OP(=O)([O-])[O-].[O-]P(=O)([O-])OP(=O)([O-])[O-].[Fe+3].[Fe+3].[Fe+3].[Fe+3] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can reversibly stabilize the neuronal membrane by binding to sodium channels. Option B: It may have a narcotic effect in high concentrations. Option C: It can catalyze free radical formation and lipid peroxidation as well as the presence of interactions of iron in plasma. Option D: It can exhibit increased blood flow into the penis, resulting in erection. " C 5206 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(OC(C(F)(F)F)C(F)(F)F)F Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits general anesthesia. Option B: It can exhibit general anesthesia effects. Option C: It can induce general anesthesia. Option D: It exhibits local anesthesia. " A 31101 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]3(N1C(=O)[C@](O3)(C(C)C)NC(=O)[C@H]4CN([C@@H]5CC6=C(NC7=CC=CC(=C67)C5=C4)Br)C)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes sustained suppression of somatotropin (growth hormone) secretion in some patients with acromegaly. Option B: It has therapeutic effects similar to salicylates, but lacks anti-inflammatory, antiplatelet, and gastric ulcerative effects. Option C: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option D: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. " A 936 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CN=C1)C(=O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes respiratory effects such as respiratory irritation, wheezing, asthma, pneumonia, and fibrosis with chronic (long-term) inhalation exposure. Option B: By inhibiting the endogenous production of cholesterol within the liver, it lowers abnormal cholesterol and lipid levels and ultimately reduces the risk of cardiovascular disease. Option C: It improves cardiac function, reduces afterload, increases cardiac output, and prevents ventricular hypertrophy and remodeling. Option D: It can lead to renal damage, chronic kidney disease, and cardiovascular disease. " D 441207 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5CC[C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)C)C)C)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It primarily affects mu-type opioid receptors, which function as modulators of synaptic transmission via G-proteins. Option B: It exhibits decreased mitosis and microtubule inhibition as its physiologic effects. Option C: It can promote activation of contractile proteins (e.g., actin, myosin) by increasing intracellular concentrations of calcium. Option D: It can interfere with cell functions, such as meiosis and intracellular transportation, by binding to microtubules. " C 6327 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has liver, kidney, immunological, endocrine, and developmental effects reported in humans. Option B: It can affect the lungs, gastrointestinal system, blood, liver, kidneys, central nervous system, and eyes. Option C: It can affect the lungs, liver, kidneys, and heart. Option D: It has liver, kidney, spleen, and central nervous system (CNS) effects in chronic (long-term) animal studies. " D 40839 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)N)O)O)CC)OC)C(=O)OC)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes severe respiratory tract irritation and inflammation in humans upon acute inhalation exposure. Option B: Acute inhalation exposure to it can cause irritation of the respiratory tract and eye irritation in humans. Option C: It blocks the effects of excessive levels of glutamate that may lead to neuronal dysfunction. Option D: Its major side effects are myelosuppression and neurotoxicity. " D 31200 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CC(=C1)OP(=S)(OC)OC)[N+](=O)[O-] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: Its health effects are consistent with those of other organophosphates and are the result of cholinesterase inhibition. Option B: It inhibits acetylcholinesterase, resulting in neurotoxic effects. Option C: It induces the effect of inhibiting the enzyme acetylcholinesterase in peripheral nerve endings. Option D: It can cause cholinesterase inhibition and neurological effects. " A 43815 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option B: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. Option C: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option D: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. " D 10112 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)([O-])[O-].[Ca+2] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can lead to the accumulation of itself and glycine in the brain when its plasma concentrations increase. Option B: It may inhibit the action of pepsin by subsequent increases in pH. Option C: Acute inhalation exposure to it can cause irritation of the respiratory tract and eye irritation in humans. Option D: It blocks the effects of excessive levels of glutamate that may lead to neuronal dysfunction. " B 7416 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It inhibits lateral shoot branching, stimulates germination of Striga, and aids in the symbiosis of over 80% of terrestrial plants with fungi at arbuscular mycorrihizae in roots. Option B: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option C: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option D: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. " C 107689 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](C(=O)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and blockage of the receptors at high levels, leading to paralysis and death. Option B: Early and effective treatment may allow the cell to revert to a normal state, as long as the oxygen machinery (i.e. mitochondria) is intact in such a scenario. Option C: It can cause increased amount of this molecule in the blood of premature infants, which is marked by decreased motor activity, lethargy and poor feeding. Option D: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. " B 7699 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCNC1=CC=C(C=C1)C(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits decreased tracheobronchial stretch receptor activity. Option B: It exhibits decreased platelet production as its physiologic effect. Option C: It results in a blockage or change in the expression of estrogen dependent genes. Option D: It is a potent, subtype-selective estrogen receptor agonist. " A 5281077 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(/C=C/Cl)(C#C)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It binds to a distinct binding site associated with a Cl- ionopore at the GABA-A receptor, increasing the duration of time for which the Cl- ionopore is open. Option B: It can interfere with L-arginine in the production of nitric oxide, a key chemical to endothelial and hence cardiovascular health. Option C: It increases cellular permeability causing leakage of cellular contents by inhibiting the synthesis of ergosterol, an essential component of the fungal cell membrane. Option D: It binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. " D 12228 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN=C=O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is associated with reproductive effects and an increased number of stillbirths and spontaneous abortions in the survivors of the Bhopal, India accident. Option B: It has a low rate of transient serum aminotransferase elevations during therapy and rare instances of clinically apparent liver injury. Option C: It is associated with transient serum aminotransferase elevations during therapy and with rare instances of clinically apparent liver injury. Option D: It can be associated with mild serum enzyme elevations and has been linked to rare instances of clinically apparent liver injury. " A 2474 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits local anesthesia. Option B: It can induce general anesthesia. Option C: It exhibits local anesthesia as its physiologic effect. Option D: It can exhibit general anesthesia effects. " A 6533629 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CO/N=C(/C1=CSC(=N1)N)\\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=CCS3)C(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has few side effects and is reported to be safe and effective. Option B: It has side effects that are a cause for concern. Option C: It has long-lasting effects and can be administered once a day. Option D: It has minimal side effects, with the most common being headache and fatigue. " A 342 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC=C1)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes centrally-mediated muscle relaxation. Option B: It results in irritation of the nose and throat. Option C: It exhibits centrally-mediated muscle relaxation. Option D: It may result in upper respiratory tract irritation and congestion. " B 3821 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC1(CCCCC1=O)C2=CC=CC=C2Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can induce general anesthesia. Option B: It can exhibit general anesthesia effects. Option C: It exhibits general anesthesia. Option D: It exhibits local anesthesia. " C 3950 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(CC1)NC(=O)N(CCCl)N=O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It inhibits DNA synthesis and stops the growth of cancer cells. Option B: It inhibits DNA synthesis and has some cell cycle phase specificity. Option C: It inhibits DNA synthesis and causes cell death. Option D: It inhibits root development and growth. " B 8378 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It inhibits adenylyl cyclase, decreases intracellular cAMP concentrations, and blocks IP3-dependent release of Ca2+ from intracellular stores. Option B: It is more potent and safer than ethinylestradiol, reducing the environmental accumulation of unwanted endocrine disrupting chemicals and harmful epigenetic effects. Option C: It interferes with mRNA binding and acceptor tRNA sites, resulting in the production of non-functional or toxic peptides. Option D: It immobilizes/inactivates/damages and/or kills sperms without eliciting systemic effects. " C 1117 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]S(=O)(=O)[O-] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It increases large intestinal motility and inhibits large intestine fluid/electrolyte absorption. Option B: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option C: It can cause transient serum enzyme elevations during therapy, rare cases of cholestatic hepatitis, instances of nodular regenerative hyperplasia, and sinusoidal obstruction syndrome when given in high doses. Option D: It can cause increased large intestinal motility and inhibition of large intestine fluid/electrolyte absorption. " A 247 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+](C)(C)CC(=O)[O-] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It decreases the serum p-cresol concentration in uremic patients. Option B: It reduces plasma homocysteine levels in patients with homocystinuria. Option C: It mimics epilepsy by blocking the inhibitory action of GABA receptors. Option D: It can reduce serum uric acid concentration through the inhibition of URAT1 and OAT4. " B 5472 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(CC2=C1SC=C2)CC3=CC=CC=C3Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can decrease platelet aggregation. Option B: It decreases prostaglandin production and platelet aggregation. Option C: It exhibits decreased platelet production as its physiologic effect. Option D: It decreases platelet aggregation. " D 1983 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)NC1=CC=C(C=C1)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option B: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option C: It has therapeutic effects similar to salicylates, but lacks anti-inflammatory, antiplatelet, and gastric ulcerative effects. Option D: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. " C 8944 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C1(CCN(CC1)CCC2=CC=C(C=C2)N)C3=CC=CC=C3 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes a reduction in major cardiovascular events without significant side effects or risks. Option B: It causes side effects in the CNS. Option C: It has side effects that are a cause for concern. Option D: It has minimal side effects, with the most common being headache and fatigue. " B 3033 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It decreases prostaglandin production and platelet aggregation. Option B: It decreases platelet aggregation. Option C: It decreases prostaglandin production. Option D: It can increase prostaglandin activity to realize its physiologic effect. " C 146570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCC[C@@]1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It blocks the D2 somatodendritic autoreceptor, resulting in the blockade of postsynaptic dopamine receptors in the mesolimbic system and an increased dopamine turnover. Option B: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option C: It can block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option D: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. " C 9854012 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CSCCNC1=C2C(=NC(=N1)SCCC(F)(F)F)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can decrease platelet aggregation. Option B: It decreases platelet aggregation. Option C: It exhibits decreased platelet aggregation. Option D: It decreases prostaglandin production and platelet aggregation. " A 47528 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CN=C1)C(=O)NCCO[N+](=O)[O-] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and receptor blockage at high levels, leading to paralysis and death. Option B: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and blockage of the receptors at high levels, leading to paralysis and death. Option C: It can induce vasodilation of arterioles and large coronary arteries by activating potassium channels. Option D: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. " C 7111 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C2=CC=C(C=C2)N)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It results in a buildup of toxic substances that are responsible for numerous adverse side effects. Option B: It causes centrally-mediated muscle relaxation. Option C: It can cause various tumor types at multiple sites. Option D: It causes harmful health effects and bioaccumulates. " C 54678486 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)CC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can inhibit vitamin-k dependent synthesis of biologically active forms of various clotting factors in addition to several regulatory factors. Option B: It has reproductive effects in women exposed by inhalation to high levels and adverse effects on the developing fetus in animal tests. Option C: It has shown similar efficacy to theophylline in the treatment of asthma, but with significantly fewer side effects in animal and human studies. Option D: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. " A 3637 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=NN=C2NN Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits arteriolar vasodilation. Option B: It exhibits increased hematopoietic stem cell mobilization. Option C: It lowers blood pressure through arteriolar vasodilation. Option D: It can cause arteriolar vasodilation. " D 10461 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCl)SCCCl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause increased cellular death. Option B: It exhibits decreased blood pressure. Option C: It can cause blindness. Option D: It can cause decreased blood pressure. " C 971 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(=O)O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause decreased blood pressure. Option B: It can cause joint pain. Option C: It can cause increased cellular death. Option D: It can cause blindness. " B 3599 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy that are usually accompanied by an increase in hepatic fat. Option B: It can cause transient mild-to-moderate serum aminotransferase elevations during the first 1 or 2 weeks of treatment, but has not been implicated in cases of clinically apparent liver injury with jaundice. Option C: It is associated with elevations in serum aminotransferase levels, acute liver injury, and noncirrhotic portal hypertension with long-term use. Option D: It has been linked to mild, transient elevations in serum aminotransferase levels during therapy as well as rare instances of idiosyncratic drug-induced liver disease. " B 6329 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can target the voltage-operated neuronal potassium channels, probably inducing release of neurotransmitter(s). Option B: It works by blocking the transporter reuptake proteins for key neurotransmitters affecting mood, leaving more active neurotransmitter in the synapse. Option C: It potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking cortical and limbic arousal following stimulation of the reticular pathways. Option D: It can mimic the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain transmission. " A 5284616 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can decrease blood pressure to realize its physiologic effect. Option B: It exhibits decreased sympathetic activity as its physiologic effect. Option C: It can decrease immunologic activity. Option D: Its physiologic effect is by means of decreased immunologic activity. " C 53232 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is irritant but produces no acute systemic effects and has no demonstrable genotoxic potential. Option B: It causes a reduction in major cardiovascular events without significant side effects or risks. Option C: It causes no greater fecal gastrointestinal blood loss than placebo, in contrast to aspirin. Option D: It can cause a 20%-22% relative reduction in major cardiovascular events for every 1 mmol/L reduction in LDL without any significant side effects or risks. " D 54684141 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C(=C(\\C#N)/C(=O)NC1=CC=C(C=C1)C(F)(F)F)/O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes clinically apparent acute liver injury and rare instances of death. Option B: It is associated with transient serum enzyme elevations during therapy and with rare instances of acute liver injury. Option C: It has a low rate of transient serum aminotransferase elevations during therapy and rare instances of clinically apparent liver injury. Option D: It is associated with transient serum aminotransferase elevations during therapy and with rare instances of clinically apparent liver injury. " B 5311071 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]\\1CC[C@@H](C/C1=C\\C=C\\2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)/C=C/[C@H](C)C(C)C)C)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It decreases serum calcium by inhibiting tumor-induced bone resorption and reducing calcium flow from the resorbing bone into the blood in malignancy-related hypercalcemia. Option B: It can stimulate intestinal calcium absorption and increase renal phosphate excretion. Option C: It can promote sodium and water excretion and potassium retention by competitively inhibiting mineralocorticoid receptors in the distal convoluted tubule. Option D: It can effectively and safely increase lumbar and hip bone mineral density in osteoporotic patients who also received vitamin D3 supplementation. " B 281 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C-]#[O+] Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: Prolonged and repeated contact with it may cause defatting and drying of the skin. Option B: It impairs energy-requiring processes, such as recovery from potentially lethal damage induced by radiation treatment and some cytotoxic drugs. Option C: It does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. Option D: Prolonged exposure to carbon monoxide rich atmospheres may be fatal. " D 6166 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)CO)CCC4=CC(=O)CC[C@]34C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It stimulates the collecting tubules in the kidney to continue to excrete potassium in much the same way that aldosterone does. Option B: It can induce vasodilation of arterioles and large coronary arteries by activating potassium channels. Option C: It can promote sodium and water excretion and potassium retention by competitively inhibiting mineralocorticoid receptors in the distal convoluted tubule. Option D: It leads to relaxation of smooth muscle in the prostate and detrusor muscles in the bladder, improving urinary flow. " A 5411 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCNC1=CC=C(C=C1)C(=O)OCCN(C)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits local anesthesia as its physiologic effect. Option B: It exhibits decreased platelet production as its physiologic effect. Option C: It can exhibit general anesthesia as its physiologic effect. Option D: It exhibits decreased sympathetic activity as its physiologic effect. " A 2131 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)CC1=CC=CC=C1Cl)CC2=CC=CC=C2Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It inhibits lateral shoot branching, stimulates germination of Striga, and aids in the symbiosis of over 80% of terrestrial plants with fungi at arbuscular mycorrihizae in roots. Option B: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option C: It inhibits acetylcholine hydrolysis and enhances cholinergic function through the accumulation of acetylcholine at cholinergic synapses. Option D: It blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors, depresses the release of hypothalamic and hypophyseal hormones, and affects basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. " C 9565 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCOC1=CN=C(N=C1)NS(=O)(=O)C2=CC=CC=C2 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can stimulate the release of insulin from the pancreatic beta cells and increase the insulin-mediated peripheral glucose uptake. Option B: It stimulates the release of insulin from functioning pancreatic beta cells and increases sensitivity of peripheral tissues to insulin. Option C: It leads to relaxation of smooth muscle in the prostate and detrusor muscles in the bladder, improving urinary flow. Option D: It can cause inhibition of the action of angiotensin II on vascular smooth muscle, leading to a reduction in arterial blood pressure. " B 39186 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)O[C@@H]1[C@@H](SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It leads to dilation of the coronary and systemic arteries and improved oxygen delivery to the myocardial tissue. Option B: It leads to relaxation of smooth muscle in the prostate and detrusor muscles in the bladder, improving urinary flow. Option C: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and receptor blockage at high levels, leading to paralysis and death. Option D: It can induce vasodilation of arterioles and large coronary arteries by activating potassium channels. " A 5282054 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C=C/C/C=C/CCC(=O)[C@@H]1[C@@H](O1)C(=O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes significant discomfort throughout the day and requires frequent treatment with eye drops. Option B: It causes severe respiratory tract irritation and inflammation in humans upon acute inhalation exposure. Option C: Acute inhalation exposure to it can cause irritation of the respiratory tract and eye irritation in humans. Option D: It inhibits feeding and induces dramatic weight loss in mice. " D 119 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(=O)O)CN Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes overexcitation, paralysis, and death in insects. Option B: It causes delayed repolarization and paralysis of pests. Option C: It causes mucous membrane and eye irritation, and gastrointestinal effects. Option D: It causes hyperpolarization by typically resulting in a negative change in the transmembrane potential. " D 222 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause blindness. Option B: It can cause increased cellular death. Option C: It can cause frostbite upon direct contact. Option D: It can cause frostbite upon contact with the unconfined liquid. " D 1615 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CC1=CC2=C(C=C1)OCO2)NC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It down-regulates cerebral cortical β-adrenergic receptors and sensitizes post-synaptic serotonergic receptors with chronic use. Option B: It down-regulates cerebral cortical β-adrenergic receptors and sensitizes post-synaptic serotonergic receptors with chronic use, similar to TCAs. Option C: It can down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. Option D: It is a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. " D 72385 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCC1=CC=C(C=C1)OCCOCCOCCOCCOCCOCCOCCOCCOCCO Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option B: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted. Option C: It impairs energy-requiring processes, such as recovery from potentially lethal damage induced by radiation treatment and some cytotoxic drugs. Option D: It immobilizes/inactivates/damages and/or kills sperms without eliciting systemic effects. " D 3291 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC1(CC(=O)NC1=O)C Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It exhibits the physiologic effect of decreased central nervous system disorganized electrical activity. Option B: It exhibits decreased central nervous system disorganized electrical activity as its physiologic effect. Option C: It can decrease central nervous system disorganized electrical activity to realize its physiologic effect. Option D: It can decrease central nervous system disorganized electrical activity. " B 9033 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN1 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It causes severe respiratory tract irritation and inflammation in humans upon acute inhalation exposure. Option B: Acute inhalation exposure to it can cause irritation of the respiratory tract and eye irritation in humans. Option C: It causes respiratory effects such as respiratory irritation, wheezing, asthma, pneumonia, and fibrosis with chronic (long-term) inhalation exposure. Option D: It can cause respiratory effects from chronic inhalation exposure and skin irritation and sensitization from dermal exposure. " A 5283509 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCC(CO)O)OC(=O)CCCCCCC/C=C\\CCCCCCCC Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and blockage of the receptors at high levels, leading to paralysis and death. Option B: It compensates for alveolar surfactant deficiency and reduces the likelihood of alveolar collapse leading to acute respiratory collapse. Option C: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option D: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and receptor blockage at high levels, leading to paralysis and death. " B 1032 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is irritant but produces no acute systemic effects and has no demonstrable genotoxic potential. Option B: It has good tolerance, lack of toxicity, and no dose-limiting side effects. Option C: It has a decreased incidence of adverse effects compared to high dose monotherapy in the treatment of moderate hypertension. Option D: It has shown similar efficacy to theophylline in the treatment of asthma, but with significantly fewer side effects in animal and human studies. " A 10258 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=CN2)OS(=O)(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It increases the rate of progression of renal failure. Option B: It can suppress hunger signals and appetite. Option C: It suppresses hunger signals and appetite. Option D: It can suppress appetite. " A 39562 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=NN2CC3=C(C=C(C=C3)Cl)Cl)C(=O)O Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. Option B: It impairs energy-requiring processes, such as recovery from potentially lethal damage induced by radiation treatment and some cytotoxic drugs. Option C: It produces anti-androgenic effects in animals by reducing testosterone production and, at very high levels, reducing estrogen production, possibly by inhibiting testicular and ovarian steroidogenesis. Option D: It can have effects of ionizing and non-ionizing radiation, air pollution and natural toxic gases such as ozone, and chemicals and toxins including oxidizing disinfectants. " B 3033621 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)C2=NC(C(=O)N(C3=C2C=C(C=C3)Cl)CCC#N)O)F Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking cortical and limbic arousal following stimulation of the reticular pathways. Option B: It can potentiate the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways. Option C: It inhibits lateral shoot branching, stimulates germination of Striga, and aids in the symbiosis of over 80% of terrestrial plants with fungi at arbuscular mycorrihizae in roots. Option D: It increases secretion by the exocrine glands, and produces contraction of the iris sphincter muscle and ciliary muscle (when given topically to the eyes) by mainly stimulating muscarinic receptors. " A 8612 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCOC(=O)C1=C(C=C(C=C1)N)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can exhibit general anesthesia effects. Option B: It can induce general anesthesia. Option C: It exhibits local anesthesia. Option D: It can exhibit general anesthesia as its physiologic effect. " C 5284570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3C(=O)CC4 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It can produce significant adverse effects in the GI tract. Option B: It has a very high potency and a comparable side effect profile to the parent compound. Option C: It has a comparatively favorable adverse effect profile. Option D: It can be associated with mild serum enzyme elevations and has been linked to rare instances of clinically apparent liver injury. " B 105089 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC[C@@H](C(=O)O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It increases secretion by the exocrine glands, and produces contraction of the iris sphincter muscle and ciliary muscle (when given topically to the eyes) by mainly stimulating muscarinic receptors. Option B: It can potentiate the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways. Option C: It potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking cortical and limbic arousal following stimulation of the reticular pathways. Option D: It induces oxidative stress in neurons by depleting glutathione through the activation of the metabotropic glutamate receptor 5. " D 6305 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: Limited information is available on the acute and chronic effects of this molecule in humans. Option B: Excess of this molecule in the blood may contribute to mental retardation. Option C: It can cause increased amount of this molecule in the blood of premature infants, which is marked by decreased motor activity, lethargy and poor feeding. Option D: Acute exposure to this molecule affects the blood with clinical signs of central nervous system depression. " B 8730 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)C[C@H](C(=O)O)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It mimics epilepsy by blocking the inhibitory action of GABA receptors. Option B: It primarily affects mu-type opioid receptors, which function as modulators of synaptic transmission via G-proteins. Option C: It exerts a broad spectrum of stimulatory effects on cell metabolism. Option D: It leads to aberrant cell growth and proliferation in some cancers. " C 4189 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It inhibits ergosterol synthesis, resulting in increased cellular permeability and leakage of cellular contents. Option B: It increases cellular permeability causing leakage of cellular contents by inhibiting the synthesis of ergosterol, an essential component of the fungal cell membrane. Option C: It depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. Option D: It inhibits ergosterol synthesis, resulting in increased cellular permeability. " A 3100 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes. Option B: It can lead to lower steady-state levels of HNE, and these cells acquire resistance to apoptosis induced by lipid peroxidation-causing agents such as H(2)O(2), UVA, superoxide anion, and pro-oxidant xenobiotics. Option C: It has fewer side-effects and CNS stimulatory effects compared to the enantiomer (+)-(1S,2S)-Pseudoephedrine, while retaining its efficacy as a decongestant. Option D: It is associated with transient and usually mild elevations in serum aminotransferase during therapy and to rare instances of self-limited, clinically apparent idiosyncratic acute liver injury as well as to cases of reactivation of hepatitis B in susceptible individuals. " C 4114 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It produces anti-androgenic effects in animals by reducing testosterone production and, at very high levels, reducing estrogen production, possibly by inhibiting testicular and ovarian steroidogenesis. Option B: After activation, it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA and inhibiting DNA synthesis and function. Option C: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and receptor blockage at high levels, leading to paralysis and death. Option D: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation. " B 5282443 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)/C(=C\\CN2CCCC2)/C3=CC=CC=N3 Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It may cause drowsiness. Option B: It can cause joint pain. Option C: It can cause blindness. Option D: It can cause increased cellular death. " A 3301 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CN)N Question about this molecule: Which kind of effects does this molecule have/exhibit? Option A: It increases histamine release and cell-mediated immunity. Option B: It can decrease histamine release. Option C: It exhibits decreased histamine release. Option D: It increases diuresis. " A 1486 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1Cl)Cl)OCC(=O)O Question about this molecule: What is the right information about this molecule's environmental impact? Option A: It easily penetrates the soil to contaminate groundwater and nearby waterways. Option B: It easily penetrates the soil to contaminate groundwater and waterways. Option C: It can easily penetrate the soil and contaminate groundwater and nearby streams. Option D: It easily penetrates the soil and contaminates groundwater or nearby waterways. " A 6579 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC(=O)N Question about this molecule: What is the right information about this molecule's environmental impact? Option A: Spills can easily penetrate the soil and contaminate groundwater and nearby streams. Option B: It easily penetrates the soil to contaminate groundwater and nearby waterways. Option C: It can easily penetrate the soil and contaminate groundwater or streams. Option D: It can easily penetrate the soil and contaminate groundwater and nearby streams. " A 5455 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C(=S)SSC(=S)N(C)C Question about this molecule: What is the right information about this molecule's environmental impact? Option A: It easily penetrates the soil to contaminate groundwater and waterways. Option B: It easily penetrates the soil and contaminates groundwater or nearby waterways. Option C: It easily penetrates the soil to contaminate groundwater and nearby waterways. Option D: It can easily penetrate the soil and contaminate groundwater and nearby streams. " A 3030 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C=CC(=C1C(=O)O)Cl)Cl Question about this molecule: What is the right information about this molecule's environmental impact? Option A: It can easily penetrate the soil and contaminate groundwater or streams. Option B: It can easily penetrate the soil and contaminate groundwater and nearby streams. Option C: It easily penetrates the soil to contaminate groundwater and nearby waterways. Option D: Spills can easily penetrate the soil and contaminate groundwater and nearby streams. " B 3031 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C(=C1)Cl)C#N)Cl Question about this molecule: What is the right information about this molecule's environmental impact? Option A: It can easily penetrate the soil and contaminate groundwater and nearby streams. Option B: Spills can easily penetrate the soil and contaminate groundwater and nearby streams. Option C: It easily penetrates the soil to contaminate groundwater and nearby waterways. Option D: It can easily penetrate the soil and contaminate groundwater or streams. " A 6389 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(F)(Cl)(Cl)Cl Question about this molecule: What is the right information about this molecule's environmental impact? Option A: It easily penetrates the soil to contaminate groundwater and waterways. Option B: It easily penetrates the soil to contaminate groundwater and nearby waterways. Option C: It can easily penetrate the soil and contaminate groundwater and nearby streams. Option D: It easily penetrates the soil and contaminates groundwater or nearby waterways. " B 8184 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCO Question about this molecule: What is the right information about this molecule's environmental impact? Option A: It easily penetrates the soil to contaminate groundwater and nearby waterways. Option B: It can easily penetrate the soil and contaminate groundwater or streams. Option C: It can easily penetrate the soil and contaminate groundwater and nearby streams. Option D: Spills can easily penetrate the soil and contaminate groundwater and nearby streams. " B 27125 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1[C@H]([C@H]([C@@H]2O)O)O)CCC4=C3C=CC(=C4)O Question about this molecule: What is the right information about this molecule's environmental impact? Option A: It can easily penetrate the soil and contaminate groundwater and nearby streams. Option B: It can easily penetrate the soil and contaminate groundwater or streams. Option C: It reduces the environmental accumulation of unwanted endocrine disrupting chemicals (EDCs) that often lead to harmful epigenetic effects. Option D: Spills can easily penetrate the soil and contaminate groundwater and nearby streams. " C 8268 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C(C2=CC=C(C=C2)Cl)(C(Cl)(Cl)Cl)O)Cl Question about this molecule: What is the right information about this molecule's environmental impact? Option A: Spills can easily penetrate the soil and contaminate groundwater and nearby streams. Option B: It can easily penetrate the soil and contaminate groundwater or streams. Option C: It easily penetrates the soil to contaminate groundwater and nearby waterways. Option D: It can easily penetrate the soil and contaminate groundwater and nearby streams. " D 7768 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(=O)NCC1 Question about this molecule: What is the right information about this molecule's environmental impact? Option A: It easily penetrates the soil to contaminate groundwater and nearby waterways. Option B: Spills can easily penetrate the soil and contaminate groundwater and nearby streams. Option C: It can easily penetrate the soil and contaminate groundwater and nearby streams. Option D: It can easily penetrate the soil and contaminate groundwater or streams. " C 240 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C=O Question about this molecule: What is the right information about this molecule's environmental impact? Option A: It easily penetrates the soil to contaminate groundwater and waterways. Option B: It easily penetrates the soil to contaminate groundwater and nearby waterways. Option C: It easily penetrates the soil and contaminates groundwater or nearby waterways. Option D: It can easily penetrate the soil and contaminate groundwater and nearby streams. " B 4420 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=O)(OC)OC(C(Cl)(Cl)Br)Br Question about this molecule: What is the right information about this molecule's environmental impact? Option A: It can easily penetrate the soil and contaminate groundwater and nearby streams. Option B: It easily penetrates the soil to contaminate groundwater and nearby waterways. Option C: Spills can easily penetrate the soil and contaminate groundwater and nearby streams. Option D: It can easily penetrate the soil and contaminate groundwater or streams. " A 3026 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC Question about this molecule: What is the right information about this molecule's environmental impact? Option A: It can easily penetrate the soil and contaminate groundwater and nearby streams. Option B: It easily penetrates the soil to contaminate groundwater and nearby waterways. Option C: It can easily penetrate the soil and contaminate groundwater or streams. Option D: Spills can easily penetrate the soil and contaminate groundwater and nearby streams. " A 5271805 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)OC)O)C4=C(C=C(C5=C4OC(=CC5=O)C6=CC=C(C=C6)O)O)O Question about this molecule: What is the enzyme inhibition of this molecule? Option A: It acts as a cyclooxygenase 2 inhibitor. Option B: It inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase. Option C: It exhibits inhibitory activities towards arachidonate 5-lipoxygenase and cyclooxygenase 2. Option D: It acts as an acetylcholinesterase inhibitor. " C 10212 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCOC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2)C Question about this molecule: What is the enzyme inhibition of this molecule? Option A: It potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM). Option B: It acts as an inhibitor of the enzyme mu-calpain (EC 3.4.22.52). Option C: It is a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2). Option D: It acts as an acetylcholinesterase inhibitor. " D 12314983 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@@H]([C@H](OC2=C1C=CC(=C2)O)C3=CC(=C(C(=C3)O)O)O)O Question about this molecule: What is the enzyme inhibition of this molecule? Option A: It acts as an inhibitor of the enzyme mu-calpain (EC 3.4.22.52). Option B: It exhibits inhibitory activity against alpha-amylase and lipase. Option C: It exhibits alpha-glucosidase inhibitory activity. Option D: It is an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. " B 71398 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](CC1=CC(=C(C=C1)O)O)[C@@H](C)CC2=CC(=C(C=C2)O)O Question about this molecule: What is the enzyme inhibition of this molecule? Option A: It acts as an acetylcholinesterase inhibitor. Option B: It exhibits inhibitory activities towards arachidonate 5-lipoxygenase and cyclooxygenase 2. Option C: It inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase. Option D: It acts as a cyclooxygenase 2 inhibitor. " C 181817 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)[C@H]1C(=O)O Question about this molecule: What is the enzyme inhibition of this molecule? Option A: (S)-ketorolac is a COX1 and COX2 inhibitor. Option B: It acts as a cyclooxygenase 2 inhibitor. Option C: It exhibits alpha-glucosidase inhibitory activity. Option D: It exhibits inhibitory activity against alpha-amylase and lipase. " A 25181116 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC1=C(C(=C2C(=C1O)C(=O)C(=C(O2)C3=CC(=C(C=C3)C[C@@H](C(=C)C)O)O)O)CC=C(C)C)O)C Question about this molecule: What is the enzyme inhibition of this molecule? Option A: It is an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. Option B: It acts as an inhibitor of the enzyme mu-calpain (EC 3.4.22.52). Option C: It exhibits alpha-glucosidase inhibitory activity. Option D: It exhibits inhibitory activity against alpha-amylase and lipase. " C 135413520 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].[Na+].[Na+] Question about this molecule: What is the enzyme inhibition of this molecule? Option A: It inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). Option B: It is a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2). Option C: It acts as an inhibitor of the enzyme mu-calpain (EC 3.4.22.52). Option D: It potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM). " A 68081 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCOC1=C2C=CC(=O)OC2=CC3=C1C=CO3)C Question about this molecule: What is the enzyme inhibition of this molecule? Option A: It acts as an inhibitor of the enzyme mu-calpain (EC 3.4.22.52). Option B: It is a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2). Option C: It potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM). Option D: It acts as an acetylcholinesterase inhibitor. " D 135410875 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)N[C@@H](CCC(=O)O)C(=O)O Question about this molecule: What is the enzyme inhibition of this molecule? Option A: It acts as an inhibitor of the enzyme mu-calpain (EC 3.4.22.52). Option B: It is a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2). Option C: It inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). Option D: It potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM). " C 135564751 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.O.O.[Na+].[Na+] Question about this molecule: What is the enzyme inhibition of this molecule? Option A: It is a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2). Option B: It potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM). Option C: It acts as an inhibitor of the enzyme mu-calpain (EC 3.4.22.52). Option D: It inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). " D 56329 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@H]2CCCN3CCC[C@H](N3C2=O)C(=O)O.O Question about this molecule: What is the enzyme inhibition of this molecule? Option A: It is an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. Option B: It exhibits inhibitory activity against alpha-amylase and lipase. Option C: It exhibits alpha-glucosidase inhibitory activity. Option D: It is an EC 5.99.1.2 (DNA topoisomerase) inhibitor. " A 472335 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC=C5[N+](=O)[O-])N=C4C3=C2)O Question about this molecule: What is the enzyme inhibition of this molecule? Option A: It is an EC 5.99.1.2 (DNA topoisomerase) inhibitor. Option B: It exhibits inhibitory activity against alpha-amylase and lipase. Option C: It is an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. Option D: It exhibits alpha-glucosidase inhibitory activity. " A 25147638 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC1=C(C=C(C=C1)C2=C(C(=O)C3=C(C(=C(C(=C3O2)CC=C(C)C)O)CC=C(C)C)O)O)O)C Question about this molecule: What is the enzyme inhibition of this molecule? Option A: It exhibits inhibitory activity against alpha-amylase and lipase. Option B: It is an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. Option C: It exhibits alpha-glucosidase inhibitory activity. Option D: It acts as an inhibitor of the enzyme mu-calpain (EC 3.4.22.52). " C 297 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C Question about this molecule: What is the right information about this molecule's excretion? Option A: It leads to excretion of these amino acids. Option B: Increased quantities appear in the urine. Option C: It is excreted in expired air. Option D: Most of it undergoes excretion in the urine. " C 135403648 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O Question about this molecule: What is the right information about this molecule's excretion? Option A: The main routes for the excretion are via kidney/urine and the bile/feces. Option B: It is excreted in the urine, partly unmetabolized and partly after hydrolysis to DMA. Option C: Removal of the unconjugated p-cresol is, at least in part, via the urine. Option D: The dextro form is slowly excreted by the kidneys. " D 674 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC Question about this molecule: What is the right information about this molecule's excretion? Option A: Removal of the unconjugated p-cresol is, at least in part, via the urine. Option B: The main routes for the excretion are via kidney/urine and the bile/feces. Option C: The dextro form is slowly excreted by the kidneys. Option D: It is excreted in the urine, partly unmetabolized and partly after hydrolysis to DMA. " D 444305 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C@@H]([C@H](C(=O)O)O)(C(=O)O)O Question about this molecule: What is the right information about this molecule's excretion? Option A: Approximately 12 to 45 percent is excreted unchanged in urine. Option B: It is excreted in the urine, partly unmetabolized and partly after hydrolysis to DMA. Option C: Only about 15-20% of consumed it is secreted in the urine unchanged. Option D: The dextro form is slowly excreted by the kidneys. " C 243 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(=O)O Question about this molecule: What is the right information about this molecule's excretion? Option A: Increased quantities appear in the urine. Option B: It is excreted in expired air. Option C: It leads to excretion of these amino acids. Option D: Most of it undergoes excretion in the urine. " C 967 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(NC(=O)NC1=O)C(=O)O Question about this molecule: What is the right information about this molecule's excretion? Option A: Increased quantities appear in the urine. Option B: Only about 15-20% of consumed it is secreted in the urine unchanged. Option C: Most of it undergoes excretion in the urine. Option D: Approximately 12 to 45 percent is excreted unchanged in urine. " A 2879 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)O Question about this molecule: What is the right information about this molecule's excretion? Option A: The main routes for the excretion are via kidney/urine and the bile/feces. Option B: The dextro form is slowly excreted by the kidneys. Option C: Removal of the unconjugated p-cresol is, at least in part, via the urine. Option D: It is excreted in the urine, partly unmetabolized and partly after hydrolysis to DMA. " C 54680690 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)[C@H]1[C@@H]2C[C@@H]3[C@@H](C4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)Cl)O Question about this molecule: What is the right information about this molecule's excretion? Option A: It is excreted more slowly than tetracycline. Option B: The dextro form is slowly excreted by the kidneys. Option C: It is excreted in the urine, partly unmetabolized and partly after hydrolysis to DMA. Option D: Approximately 12 to 45 percent is excreted unchanged in urine. " A 135398559 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@@H](N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O Question about this molecule: What is the right information about this molecule's excretion? Option A: The dextro form is slowly excreted by the kidneys. Option B: Removal of the unconjugated p-cresol is, at least in part, via the urine. Option C: It is excreted in the urine, partly unmetabolized and partly after hydrolysis to DMA. Option D: The main routes for the excretion are via kidney/urine and the bile/feces. " A 1030 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CO)O Question about this molecule: What is the right information about this molecule's excretion? Option A: It is excreted in the urine, partly unmetabolized and partly after hydrolysis to DMA. Option B: Only about 15-20% of consumed it is secreted in the urine unchanged. Option C: Approximately 12 to 45 percent is excreted unchanged in urine. Option D: The dextro form is slowly excreted by the kidneys. " C 23976 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Cr] Question about this molecule: What is the right information about this molecule's excretion? Option A: Removal of the unconjugated p-cresol is, at least in part, via the urine. Option B: It is excreted in the urine, partly unmetabolized and partly after hydrolysis to DMA. Option C: The main routes for the excretion are via kidney/urine and the bile/feces. Option D: The dextro form is slowly excreted by the kidneys. " C 222 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: N Question about this molecule: What is the right information about this molecule's excretion? Option A: Only about 15-20% of consumed it is secreted in the urine unchanged. Option B: Approximately 12 to 45 percent is excreted unchanged in urine. Option C: Increased quantities appear in the urine. Option D: Most of it undergoes excretion in the urine. " D 8029 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=COC=C1 Question about this molecule: How is the flammability of this molecule Option A: It is very flammable. Option B: It is extremely flammable. Option C: It is flammable. Option D: It is highly flammable. " D 8255 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=C)C Question about this molecule: How is the flammability of this molecule Option A: It is very flammable. Option B: It is highly flammable. Option C: It is flammable. Option D: It is extremely flammable. " B 2256 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC1=NC(=NC(=N1)Cl)NC(C)C Question about this molecule: How is the flammability of this molecule Option A: It is highly flammable. Option B: It is very flammable. Option C: It is not flammable. Option D: It is flammable. " C 6589 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C(C)C Question about this molecule: How is the flammability of this molecule Option A: It is very flammable. Option B: It is flammable. Option C: It is extremely flammable. Option D: It is highly flammable. " D 23953 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [SiH4] Question about this molecule: How is the flammability of this molecule Option A: It is highly flammable. Option B: It is extremely flammable. Option C: It is flammable. Option D: It is very flammable. " A 6359 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)(Cl)Br Question about this molecule: How is the flammability of this molecule Option A: It is highly flammable. Option B: It is not flammable. Option C: It is flammable. Option D: It is very flammable. " B 7845 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC=C Question about this molecule: How is the flammability of this molecule Option A: It is extremely flammable. Option B: It is very flammable. Option C: It is flammable. Option D: It is highly flammable. " D 145068 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N]=O Question about this molecule: How is the flammability of this molecule Option A: It will accelerate the burning of combustible material. Option B: It is noncombustible but supports the burning of combustible materials. Option C: It accelerates the burning of combustible material. Option D: It accelerates the burning of combustible materials. " C 379 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCC(=O)O Question about this molecule: How is the flammability of this molecule Option A: It is difficult to burn. Option B: It does not readily burn. Option C: It may be difficult to ignite. Option D: It burns but may be difficult to ignite. " C 9625 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(F)(F)(Cl)Br Question about this molecule: How is the flammability of this molecule Option A: It is highly flammable. Option B: It is flammable. Option C: It is very flammable. Option D: It is not flammable. " D 8058 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC Question about this molecule: How is the flammability of this molecule Option A: It is flammable. Option B: It is highly flammable. Option C: It is extremely flammable. Option D: It is very flammable. " B 674 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC Question about this molecule: How is the flammability of this molecule Option A: It is flammable. Option B: It is extremely flammable. Option C: It is highly flammable. Option D: It is very flammable. " A 4130 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=S)(OC)OC1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: How is the flammability of this molecule Option A: It is combustible. Option B: It accelerates the burning of combustible material. Option C: It is combustible but difficult to ignite. Option D: It is combustible but does not ignite easily. " A 104748 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OS(=O)[O-] Question about this molecule: How is the flammability of this molecule Option A: It is non-flammable. Option B: It is highly flammable. Option C: It is nonflammable. Option D: It is flammable. " C 6575 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=C(Cl)Cl)Cl Question about this molecule: How is the flammability of this molecule Option A: It is nonflammable. Option B: It is non-flammable. Option C: It is highly flammable. Option D: It is flammable. " A 6212 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)(Cl)Cl Question about this molecule: How is the flammability of this molecule Option A: It burns under extreme conditions. Option B: It burns. Option C: It burns easily. Option D: It burns but may be difficult to ignite. " A 6338 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCl Question about this molecule: How is the flammability of this molecule Option A: It burns but may be difficult to ignite. Option B: It burns under extreme conditions. Option C: It burns easily. Option D: It burns. " C 6324 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC Question about this molecule: How is the flammability of this molecule Option A: It is extremely flammable. Option B: It is very flammable. Option C: It is highly flammable. Option D: It is flammable. " C 10039 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)=S Question about this molecule: How is the flammability of this molecule Option A: It is a flammable gas with a distinct sulfide odor. Option B: It can form a very flammable mixture with combustible materials. Option C: It is noncombustible but supports the burning of combustible materials. Option D: It is flammable over a wide range of vapor/air concentrations. " A 5460467 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Be] Question about this molecule: How is the flammability of this molecule Option A: It will burn if involved in a fire. Option B: It does not readily burn. Option C: It does not catch fire easily. Option D: It does not burn easily. " A 7434 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C=C1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: How is the flammability of this molecule Option A: It does not burn easily. Option B: It easily ignites and burns vigorously when dry. Option C: It may burn but does not ignite readily. Option D: It burns but may be difficult to ignite. " B 6574 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)Cl)Cl Question about this molecule: How is the flammability of this molecule Option A: It does not burn easily. Option B: It may burn but does not ignite readily. Option C: It does not catch fire easily. Option D: It does not readily burn. " A 887 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CO Question about this molecule: How is the flammability of this molecule Option A: It is flammable over a wide range of vapor/air concentrations. Option B: It is a flammable, poisonous liquid with a distinctive odor. Option C: It can form a very flammable mixture with combustible materials. Option D: It is a flammable gas with a somewhat sweet odor. " B 241 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=CC=C1 Question about this molecule: How is the flammability of this molecule Option A: It is flammable. Option B: It is extremely flammable. Option C: It is very flammable. Option D: It is highly flammable. " D 3118 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)SCCSCC Question about this molecule: How is the flammability of this molecule Option A: It is combustible but difficult to ignite. Option B: It burns but may be difficult to ignite. Option C: It is combustible but does not ignite easily. Option D: It may burn but does not ignite readily. " C 6354 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CO1 Question about this molecule: How is the flammability of this molecule Option A: It is a flammable, poisonous liquid with a distinctive odor. Option B: It is a flammable gas with a somewhat sweet odor. Option C: It can form a very flammable mixture with combustible materials. Option D: It is flammable over a wide range of vapor/air concentrations. " B 31276 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CCOC(=O)C Question about this molecule: How is the flammability of this molecule Option A: It is a flammable and explosive gas. Option B: It produces flammable, irritating vapor. Option C: It is a flammable liquid. Option D: It is a flammable gas. " B 8263 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(C(C(C1(F)F)(F)F)(F)F)(F)F Question about this molecule: How is the flammability of this molecule Option A: It is a flammable and explosive gas. Option B: It is a flammable liquid. Option C: It is a nonflammable gas. Option D: It is a flammable gas. " C 7847 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC=O Question about this molecule: How is the flammability of this molecule Option A: It burns under extreme conditions. Option B: It burns but may be difficult to ignite. Option C: It burns easily. Option D: It burns. " C 977 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=O Question about this molecule: How is the flammability of this molecule Option A: It is a flammable gas with a distinct sulfide odor. Option B: It is noncombustible but supports the burning of combustible materials. Option C: It is flammable over a wide range of vapor/air concentrations. Option D: It can form a very flammable mixture with combustible materials. " B 23969 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [AsH3] Question about this molecule: How is the flammability of this molecule Option A: It is a nonflammable gas. Option B: It is a flammable gas. Option C: It is a flammable and explosive gas. Option D: It is a flammable liquid. " B 6360 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C Question about this molecule: How is the flammability of this molecule Option A: It is extremely flammable. Option B: It is very flammable. Option C: They are highly flammable gases. Option D: It is highly flammable. " C 24404 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: P Question about this molecule: How is the flammability of this molecule Option A: It is a flammable liquid. Option B: It is a nonflammable gas. Option C: It is a flammable and explosive gas. Option D: It is a flammable gas. " C 784 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OO Question about this molecule: How is the flammability of this molecule Option A: It is nonflammable but can cause spontaneous combustion. Option B: It is not flammable. Option C: It is non-flammable. Option D: It is nonflammable. " A 177 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC=O Question about this molecule: How is the flammability of this molecule Option A: It is a highly flammable liquid. Option B: It is a flammable and explosive gas. Option C: It is a flammable liquid. Option D: It is a flammable gas. " C 6129 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC(=O)OC1=CC=CC2=CC=CC=C21 Question about this molecule: How is the flammability of this molecule Option A: It is combustible but does not ignite easily. Option B: It may burn but does not ignite readily. Option C: It burns but may be difficult to ignite. Option D: It is combustible but difficult to ignite. " D 7843 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC Question about this molecule: How is the flammability of this molecule Option A: It is very flammable. Option B: It is extremely flammable. Option C: It is highly flammable. Option D: They are highly flammable gases. " D 3226 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(OC(F)F)(F)F)(F)Cl Question about this molecule: How is the flammability of this molecule Option A: It is nonflammable. Option B: It is flammable. Option C: It is highly flammable. Option D: It is non-flammable. " A 23668193 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: N(=O)[O-].[Na+] Question about this molecule: How is the flammability of this molecule Option A: It will accelerate the burning of combustible material. Option B: It is noncombustible but supports the burning of combustible materials. Option C: It accelerates the burning of combustible materials. Option D: It accelerates the burning of combustible material. " A 7964 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)Cl Question about this molecule: How is the flammability of this molecule Option A: It is extremely flammable. Option B: It is flammable. Option C: It is very flammable. Option D: It is highly flammable. " B 996 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)O Question about this molecule: How is the flammability of this molecule Option A: It can catch fire. Option B: It may be difficult to ignite. Option C: It catches fire easily. Option D: It is difficult to burn. " A 180 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C Question about this molecule: How is the flammability of this molecule Option A: It is very flammable. Option B: It is extremely flammable. Option C: It is highly flammable. Option D: It is flammable. " D 22985 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [NH4+].[N+](=O)([O-])[O-] Question about this molecule: How is the flammability of this molecule Option A: It does not burn easily. Option B: It does not readily burn. Option C: It may burn but does not ignite readily. Option D: It does not catch fire easily. " B 31285 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCC=C Question about this molecule: How is the flammability of this molecule Option A: It is very flammable. Option B: It is extremely flammable. Option C: It is flammable. Option D: It is highly flammable. " C 3283 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOCC Question about this molecule: How is the flammability of this molecule Option A: It is very flammable. Option B: It is flammable. Option C: It is extremely flammable. Option D: It is highly flammable. " D 104770 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]Cl(=O)=O Question about this molecule: How is the flammability of this molecule Option A: It is a flammable gas with a distinct sulfide odor. Option B: It can form a very flammable mixture with combustible materials. Option C: It is flammable over a wide range of vapor/air concentrations. Option D: It is noncombustible but supports the burning of combustible materials. " B 6849 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC=C2[N+](=O)[O-] Question about this molecule: How is the flammability of this molecule Option A: It is very flammable. Option B: It is flammable. Option C: It is readily ignitable. Option D: It is extremely flammable. " C 6214 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)(Cl)Cl)(Cl)(Cl)Cl Question about this molecule: How is the flammability of this molecule Option A: It may burn but does not ignite readily. Option B: It does not burn easily. Option C: It does not catch fire easily. Option D: It does not readily burn. " C 6337 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCl Question about this molecule: How is the flammability of this molecule Option A: It catches fire easily. Option B: It is difficult to burn. Option C: It may be difficult to ignite. Option D: It can catch fire. " A 3286 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)SCSP(=S)(OCC)OCC Question about this molecule: How is the flammability of this molecule Option A: It burns. Option B: It burns under extreme conditions. Option C: It burns easily. Option D: It burns but may be difficult to ignite. " A 6432 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(F)(F)F)(C(F)(F)F)(F)F Question about this molecule: How is the flammability of this molecule Option A: It is nonflammable. Option B: It is non-flammable. Option C: It is highly flammable. Option D: It is flammable. " A 24268 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N+](=O)([O-])[O-].[Na+] Question about this molecule: How is the flammability of this molecule Option A: It will accelerate the burning of combustible material. Option B: It is noncombustible but supports the burning of combustible materials. Option C: It accelerates the burning of combustible materials. Option D: It accelerates the burning of combustible material. " C 5206 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(OC(C(F)(F)F)C(F)(F)F)F Question about this molecule: How is the flammability of this molecule Option A: It is flammable. Option B: It is highly flammable. Option C: It is nonflammable. Option D: It is non-flammable. " D 6327 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCl Question about this molecule: How is the flammability of this molecule Option A: It is very flammable. Option B: It is highly flammable. Option C: It is extremely flammable. Option D: It is flammable. " C 24434 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N+](=O)([O-])[O-].[K+] Question about this molecule: How is the flammability of this molecule Option A: It is noncombustible but supports the burning of combustible materials. Option B: It accelerates the burning of combustible materials. Option C: It accelerates the burning of combustible material. Option D: It will accelerate the burning of combustible material. " B 12228 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN=C=O Question about this molecule: How is the flammability of this molecule Option A: It is a flammable gas. Option B: It is a highly flammable liquid. Option C: It is a flammable liquid. Option D: It is a flammable and explosive gas. " B 5943 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)(Cl)(Cl)Cl Question about this molecule: How is the flammability of this molecule Option A: It is very flammable. Option B: It is flammable. Option C: It is not flammable. Option D: It is highly flammable. " C 1118 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OS(=O)(=O)O Question about this molecule: How is the flammability of this molecule Option A: It is difficult to burn. Option B: It may be difficult to ignite. Option C: It burns but may be difficult to ignite. Option D: It is unlikely to cause a fire. " D 11638 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CF Question about this molecule: How is the flammability of this molecule Option A: It is a flammable and explosive gas. Option B: It is a flammable gas. Option C: It is a nonflammable gas. Option D: It is a flammable liquid. " B 23668197 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]Cl=O.[Na+] Question about this molecule: How is the flammability of this molecule Option A: It burns but may be difficult to ignite. Option B: It does not readily burn. Option C: It is difficult to burn. Option D: It may be difficult to ignite. " C 6259 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(=O)CBr Question about this molecule: How is the flammability of this molecule Option A: It does not catch fire easily. Option B: It may burn but does not ignite readily. Option C: It does not readily burn. Option D: It does not burn easily. " B 931 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C=CC=CC2=C1 Question about this molecule: How is the flammability of this molecule Option A: It burns but may be difficult to ignite. Option B: It does not readily burn. Option C: It may be difficult to ignite. Option D: It is difficult to burn. " A 222 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: N Question about this molecule: How is the flammability of this molecule Option A: It burns within certain vapor concentration limits and with strong ignition. Option B: It is flammable over a wide range of vapor/air concentrations. Option C: It emits flammable vapors when heated. Option D: It emits flammable vapors above 150 °F. " A 6323 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CBr Question about this molecule: How is the flammability of this molecule Option A: It is non-flammable. Option B: It is highly flammable. Option C: It is flammable. Option D: It is nonflammable. " D 1146 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C Question about this molecule: How is the flammability of this molecule Option A: It produces flammable, irritating vapor. Option B: It emits flammable vapors when heated. Option C: It forms flammable solutions when dissolved in water. Option D: It emits flammable vapors above 150 °F. " C 783 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [HH] Question about this molecule: How is the flammability of this molecule Option A: It can form a very flammable mixture with combustible materials. Option B: It is flammable over a wide range of vapor/air concentrations. Option C: It is a flammable gas with a distinct sulfide odor. Option D: It is noncombustible but supports the burning of combustible materials. " B 2537 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C2CCC1(C(=O)C2)C)C Question about this molecule: How is the flammability of this molecule Option A: It is flammable over a wide range of vapor/air concentrations. Option B: It can form a very flammable mixture with combustible materials. Option C: It emits flammable vapors when heated. Option D: It emits flammable vapors above 150 °F. " D 8029 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=COC=C1 Question about this molecule: What is the right information about this molecule's flash point? Option A: It has a flash point below 32 °F. Option B: It has a flash point below 0 °F. Option C: It has a flash point of 20 °F. Option D: It has a flash point below 75 °F. " A 8025 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC=O Question about this molecule: What is the right information about this molecule's flash point? Option A: It has a flash point of 0 °F. Option B: It has a flash point of -20 °F. Option C: It has a flash point of -9 °F. Option D: It has a flash point of -4 °F. " D 10967 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(OCCl)Cl Question about this molecule: What is the right information about this molecule's flash point? Option A: It has a flash point below 75 °F. Option B: It has a flash point of 20 °F. Option C: It has a flash point below 32 °F. Option D: It has a flash point below 0 °F. " D 6569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)C Question about this molecule: What is the right information about this molecule's flash point? Option A: It has a flash point of -20 °F. Option B: It has a flash point of 20 °F. Option C: It has a flash point of 0 °F. Option D: It has a flash point of 30 °F. " B 6589 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C(C)C Question about this molecule: What is the right information about this molecule's flash point? Option A: It has a flash point of -4 °F. Option B: It has a flash point of 0 °F. Option C: It has a flash point of -20 °F. Option D: It has a flash point of -9 °F. " C 7840 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCBr Question about this molecule: What is the right information about this molecule's flash point? Option A: It has a flash point below 32 °F. Option B: It has a flash point below 0 °F. Option C: It has a flash point of 20 °F. Option D: It has a flash point below 75 °F. " D 335 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1O Question about this molecule: What is the right information about this molecule's flash point? Option A: It has a flash point between 190 and 196 °F. Option B: It may have a flash point between 100 and 199 °F. Option C: It has a flash point between 85 and 100 °F. Option D: It has a flash point between 140 and 175 °F. " B 8060 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCN Question about this molecule: What is the right information about this molecule's flash point? Option A: It has a flash point of 20 °F. Option B: It has a flash point of 30 °F. Option C: It has a flash point of 0 °F. Option D: It has a flash point of -20 °F. " B 8058 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC Question about this molecule: What is the right information about this molecule's flash point? Option A: It has a flash point of -9 °F. Option B: It has a flash point of -4 °F. Option C: It has a flash point of 0 °F. Option D: It has a flash point of -20 °F. " A 6560 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CO Question about this molecule: What is the right information about this molecule's flash point? Option A: It has a flash point between 140 and 175 °F. Option B: It has a flash point below 0 °F. Option C: It has a flash point between 85 and 100 °F. Option D: It has a flash point less than 0 °F. " C 6579 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC(=O)N Question about this molecule: What is the right information about this molecule's flash point? Option A: It has a flash point below 141 °F, depending on the solvent. Option B: It has a flash point between 140 and 175 °F. Option C: It has a flash point between 190 and 196 °F. Option D: It may have a flash point between 100 and 199 °F. " A 6568 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C)O Question about this molecule: What is the right information about this molecule's flash point? Option A: It has a flash point below 75 °F. Option B: It has a flash point of 20 °F. Option C: It has a flash point below 32 °F. Option D: It has a flash point below 0 °F. " D 6366 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=C(Cl)Cl Question about this molecule: What is the right information about this molecule's flash point? Option A: It has a flash point of -20 °F. Option B: It has a flash point of 0 °F. Option C: It has a flash point of -4 °F. Option D: It has a flash point of -9 °F. " B 261 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC=O Question about this molecule: What is the right information about this molecule's flash point? Option A: It has a flash point of 0 °F. Option B: It has a flash point of 30 °F. Option C: It has a flash point of -20 °F. Option D: It has a flash point of 20 °F. " D 7720 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(CC)CO Question about this molecule: What is the right information about this molecule's flash point? Option A: It has a flash point less than 0 °F. Option B: It has a flash point between 140 and 175 °F. Option C: It has a flash point between 85 and 100 °F. Option D: It has a flash point below 0 °F. " B 7852 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN Question about this molecule: What is the right information about this molecule's flash point? Option A: It has a flash point of 0 °F. Option B: It has a flash point of -4 °F. Option C: It has a flash point of -9 °F. Option D: It has a flash point of -35 °F. " D 12388 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCC Question about this molecule: What is the right information about this molecule's flash point? Option A: It has a flash point between 140 and 175 °F. Option B: It may have a flash point between 100 and 199 °F. Option C: It has a flash point between 85 and 100 °F. Option D: It has a flash point between 190 and 196 °F. " D 5976 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)N Question about this molecule: What is the right information about this molecule's flash point? Option A: It has a flash point of -20 °F. Option B: It has a flash point of -9 °F. Option C: It has a flash point of 0 °F. Option D: It has a flash point of -4 °F. " C 1068 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CSC Question about this molecule: What is the right information about this molecule's flash point? Option A: It has a flash point less than 0 °F. Option B: It has a flash point below 0 °F. Option C: It has a flash point of 0 °F. Option D: It has a flash point of -4 °F. " A 6363 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)N Question about this molecule: What is the right information about this molecule's flash point? Option A: It has a flash point of -35 °F. Option B: It has a flash point of -9 °F. Option C: It has a flash point of -4 °F. Option D: It has a flash point of 0 °F. " A 7497 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCO Question about this molecule: What is the right information about this molecule's flash point? Option A: 0 °F Option B: 103-140 °F Option C: -58 °F Option D: -36 °F " B 8094 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCC(=O)O Question about this molecule: What is the right information about this molecule's flash point? Option A: near 141 °F Option B: near 200 °F Option C: near 190 °F Option D: below 200 °F " B 1031 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCO Question about this molecule: What is the right information about this molecule's flash point? Option A: 20 °F Option B: 0 °F Option C: 53-77 °F Option D: -36 °F " C 8146 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOCCOCCO Question about this molecule: What is the right information about this molecule's flash point? Option A: near 190 °F Option B: below 200 °F Option C: near 141 °F Option D: near 200 °F " A 241 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=CC=C1 Question about this molecule: What is the right information about this molecule's flash point? Option A: 0 °F Option B: Below 0 °F Option C: 20 °F Option D: less than 0 °F " D 6544 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=O)CC(C1)(C)C Question about this molecule: What is the right information about this molecule's flash point? Option A: near 200 °F Option B: near 141 °F Option C: below 200 °F Option D: near 190 °F " A 6354 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CO1 Question about this molecule: What is the right information about this molecule's flash point? Option A: less than 0 °F Option B: 20 °F Option C: Below 0 °F Option D: 0 °F " C 7847 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC=O Question about this molecule: What is the right information about this molecule's flash point? Option A: Below 0 °F Option B: less than 0 °F Option C: 0 °F Option D: 20 °F " A 31253 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCCC(=C)C=C)C Question about this molecule: What is the right information about this molecule's flash point? Option A: near 190 °F Option B: below 200 °F Option C: near 200 °F Option D: near 141 °F " B 177 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC=O Question about this molecule: What is the right information about this molecule's flash point? Option A: -36 °F Option B: 53-77 °F Option C: 20 °F Option D: 0 °F " A 8030 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CSC=C1 Question about this molecule: What is the right information about this molecule's flash point? Option A: 20 °F Option B: 34 °F Option C: 30 °F Option D: 37 °F " C 8071 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCOC Question about this molecule: What is the right information about this molecule's flash point? Option A: 37 °F Option B: 20 °F Option C: 34 °F Option D: 53-77 °F " C 8082 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCNCC1 Question about this molecule: What is the right information about this molecule's flash point? Option A: 20 °F Option B: 34 °F Option C: 37 °F Option D: 53-77 °F " C 180 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C Question about this molecule: What is the right information about this molecule's flash point? Option A: less than 0 °F Option B: 0 °F Option C: Below 0 °F Option D: 20 °F " B 8130 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCC=O Question about this molecule: What is the right information about this molecule's flash point? Option A: near 200 °F Option B: near 190 °F Option C: near 141 °F Option D: below 200 °F " C 6337 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCl Question about this molecule: What is the right information about this molecule's flash point? Option A: -4 °F Option B: 0 °F Option C: Below 0 °F Option D: -58 °F " D 6341 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN Question about this molecule: What is the right information about this molecule's flash point? Option A: 0 °F Option B: less than 0 °F Option C: 20 °F Option D: Below 0 °F " D 6570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C=C Question about this molecule: What is the right information about this molecule's flash point? Option A: 53-77 °F Option B: 20 °F Option C: 34 °F Option D: 37 °F " B 679 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CS(=O)C Question about this molecule: What is the right information about this molecule's flash point? Option A: 20 °F Option B: 37 °F Option C: 192 °F Option D: 34 °F " C 8078 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCCCC1 Question about this molecule: What is the right information about this molecule's flash point? Option A: Below 0 °F Option B: -58 °F Option C: -4 °F Option D: 0 °F " C 7848 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCS Question about this molecule: What is the right information about this molecule's flash point? Option A: 0 °F Option B: Below 0 °F Option C: less than 0 °F Option D: 20 °F " B 12228 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN=C=O Question about this molecule: What is the right information about this molecule's flash point? Option A: 0 °F Option B: 53-77 °F Option C: 20 °F Option D: Less than 20 °F " D 31256 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)CC(C)(C)O Question about this molecule: What is the right information about this molecule's flash point? Option A: Below 141 °F Option B: near 190 °F Option C: near 141 °F Option D: near 200 °F " A 240 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C=O Question about this molecule: What is the right information about this molecule's flash point? Option A: near 141 °F Option B: near 190 °F Option C: Near 145 °F Option D: Below 141 °F " C 8020 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCOC Question about this molecule: What is the right information about this molecule's flash point? Option A: less than 0 °F Option B: Below 0 °F Option C: 0 °F Option D: 20 °F " C 5311065 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C[C@H](N(C1)C(=O)[C@@H]2CSSCCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(=O)N Question about this molecule: Which kind of half-life does this molecule have/exhibit? Option A: It has a prolonged half-life compared to endogenous ADH. Option B: It has a longer half-life than most other NSAIDs. Option C: It has a longer elimination half-life than any currently available cephalosporin. Option D: It has a longer half-life than somatostatin. " A 43507 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)CC3=CC=CC=C3CN)C(=O)O)CSC4=NN=NN4CC(=O)O Question about this molecule: Which kind of half-life does this molecule have/exhibit? Option A: It has a longer terminal elimination half-life than other drugs in this class. Option B: It has a longer elimination half-life than any currently available cephalosporin. Option C: It has a longer half-life than most other NSAIDs. Option D: It has a longer half-life than somatostatin. " B 441080 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@H]1[C@@H]2C[C@H]3[C@H]4[C@@]5(C[C@@H](C2[C@H]5O)N3[C@@H]1O)C6=CC=CC=C6N4C Question about this molecule: Which kind of half-life does this molecule have/exhibit? Option A: It has a short half-life. Option B: It has a very long half-life. Option C: It has a long half-life. Option D: It has a very short half-life. " D 208898 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C)C(=O)C3=CC=C(C=C3)OCCCN(CCCC)CCCC Question about this molecule: Which kind of half-life does this molecule have/exhibit? Option A: It has a longer half-life than most other NSAIDs. Option B: It has a shorter half-life than amiodarone. Option C: It has a longer elimination half-life than any currently available cephalosporin. Option D: It has a longer half-life than somatostatin. " B 9941444 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@H](CN2[C@@H]1C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C2=O)CC3=CC=CC=C3)CC4=CC=C(C=C4)OCC5=CC=CC=C5)CCCCN)CC6=CNC7=CC=CC=C76)C8=CC=CC=C8)OC(=O)NCCN Question about this molecule: Which kind of half-life does this molecule have/exhibit? Option A: It has a longer half-life than most other NSAIDs. Option B: It has a longer terminal elimination half-life than other drugs in this class. Option C: It has a longer elimination half-life than any currently available cephalosporin. Option D: It has a longer half-life than somatostatin. " D 4095 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2 Question about this molecule: Which kind of half-life does this molecule have/exhibit? Option A: It has a relatively long half-life. Option B: It has a comparatively longer half-life. Option C: It has a very long half-life. Option D: It has a longer half-life. " B 5732 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)C2=C(N3C=C(C=CC3=N2)C)CC(=O)N(C)C Question about this molecule: Which kind of half-life does this molecule have/exhibit? Option A: It has a short half-life. Option B: It has a very short half-life. Option C: It has a very long half-life. Option D: It has a long half-life. " A 104838 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]([C@@H]1[C@H]2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O Question about this molecule: Which kind of half-life does this molecule have/exhibit? Option A: It exhibits a longer half-life due to increased binding to plasma proteins. Option B: It has a longer half-life than most other NSAIDs. Option C: It has a longer elimination half-life than any currently available cephalosporin. Option D: It has a longer terminal elimination half-life than other drugs in this class. " A 91770 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=C(N=C1)C2=NC(C(=O)N2)(C)C(C)C)C(=O)O Question about this molecule: Which kind of half-life does this molecule have/exhibit? Option A: It has a half-life of 110 minutes. Option B: It has a half-life of about 70 hours. Option C: It has a half-life of around 120 days. Option D: It has a short half-life of 3-5 minutes. " C 54674461 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)NC1=C(N=C(N=C1N)C2=NN(C3=C2C=C(C=N3)F)CC4=CC=CC=C4F)N Question about this molecule: Which kind of half-life does this molecule have/exhibit? Option A: It has a long half-life. Option B: It has a very short half-life. Option C: It has a relatively long half-life. Option D: It has a very long half-life. " C 26623 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Hg+2] Question about this molecule: Which kind of half-life does this molecule have/exhibit? Option A: It has a long half-life. Option B: It has a very short half-life. Option C: It has a very long half-life. Option D: It has a long biological half-life. " D 104730 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Co] Question about this molecule: Which kind of half-life does this molecule have/exhibit? Option A: It has a prolonged half-life compared to endogenous ADH. Option B: It has a terminal half-life ranging from 1.4 to 3.3 hours. Option C: It has a longer elimination half-life than any currently available cephalosporin. Option D: It has a half-life of 5.27 years for 60Co and 272 days for 57Co. " D 5161 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)C(=O)OC2=CC=CC=C2C(=O)O)O Question about this molecule: Which kind of half-life does this molecule have/exhibit? Option A: It has a half-life of about 70 hours. Option B: It has a half-life of around 120 days. Option C: It has a half-life of 110 minutes. Option D: It has an elimination half-life of about 1 hour. " D 71815 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NC=C(N1CC(C)O)[N+](=O)[O-] Question about this molecule: Which kind of half-life does this molecule have/exhibit? Option A: It has a longer terminal elimination half-life than other drugs in this class. Option B: It has a longer half-life than most other NSAIDs. Option C: It has a longer elimination half-life than any currently available cephalosporin. Option D: It has a longer half-life than somatostatin. " A 1030 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CO)O Question about this molecule: Which kind of half-life does this molecule have/exhibit? Option A: It has a prolonged half-life compared to endogenous ADH. Option B: It has a terminal half-life ranging from 1.4 to 3.3 hours. Option C: It has a longer elimination half-life than any currently available cephalosporin. Option D: It has a longer half-life than most other NSAIDs. " B 657181 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6 Question about this molecule: Which kind of half-life does this molecule have/exhibit? Option A: It has a circulating half-life of approximately three hours. Option B: It has a short half-life of 3-5 minutes. Option C: It has a half-life of 110 minutes. Option D: It has a half-life of about 70 hours. " A 441207 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5CC[C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)C)C)C)O)O Question about this molecule: Which kind of half-life does this molecule have/exhibit? Option A: It has a longer half-life than somatostatin. Option B: It has a longer elimination half-life than any currently available cephalosporin. Option C: It has a longer half-life than digoxin. Option D: It has a longer half-life than most other NSAIDs. " C 2405 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O Question about this molecule: Which kind of half-life does this molecule have/exhibit? Option A: It has a short half-life. Option B: It has a long half-life. Option C: It has a very short half-life. Option D: It has a very long half-life. " B 5910 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@H]1[C@H](COC1=O)CC2=CN=CN2C Question about this molecule: What is the right information about this molecule's hydrolysis? Option A: It can undergo irreversible hydrolysis to 2,3-diketogulonic acid. Option B: It is partially hydrolyzed in the small intestine to two molecules of salicylic acid. Option C: It is slowly hydrolyzed. Option D: It undergoes hydrolysis to form diclofop-acid. " C 39985 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C(=O)OC)OC1=CC=C(C=C1)OC2=C(C=C(C=C2)Cl)Cl Question about this molecule: What is the right information about this molecule's hydrolysis? Option A: It is slowly hydrolyzed. Option B: It can undergo irreversible hydrolysis to 2,3-diketogulonic acid. Option C: It undergoes hydrolysis to form diclofop-acid. Option D: It is partially hydrolyzed in the small intestine to two molecules of salicylic acid. " C 5161 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)C(=O)OC2=CC=CC=C2C(=O)O)O Question about this molecule: What is the right information about this molecule's hydrolysis? Option A: It can undergo irreversible hydrolysis to 2,3-diketogulonic acid. Option B: It undergoes hydrolysis to form diclofop-acid. Option C: It is slowly hydrolyzed. Option D: It is partially hydrolyzed in the small intestine to two molecules of salicylic acid. " D 440667 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@@H]([C@@H]1C(=O)C(=O)C(=O)O1)O)O Question about this molecule: What is the right information about this molecule's hydrolysis? Option A: It is slowly hydrolyzed. Option B: It can undergo irreversible hydrolysis to 2,3-diketogulonic acid. Option C: It undergoes hydrolysis to form diclofop-acid. Option D: It is partially hydrolyzed in the small intestine to two molecules of salicylic acid. " B 8378 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N Question about this molecule: What is the right information about this molecule's hydrolysis? Option A: It can undergo irreversible hydrolysis to 2,3-diketogulonic acid. Option B: It is partially hydrolyzed in the small intestine to two molecules of salicylic acid. Option C: It undergoes hydrolysis to form diclofop-acid. Option D: It yields neamine and neobiosamine B on hydrolysis. " D 1196 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC(N=C1)C(=O)O Question about this molecule: What is the right information about this molecule's hydrolysis? Option A: It can undergo irreversible hydrolysis to 2,3-diketogulonic acid. Option B: It is partially hydrolyzed in the small intestine to two molecules of salicylic acid. Option C: It undergoes hydrolysis to form diclofop-acid. Option D: It is hydrolyzed to L-glutamate by delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12, ALDH4A1). " D 8255 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=C)C Question about this molecule: How is the ignitability of this molecule Option A: It is easily ignited in air Option B: It is easily ignited Option C: The mixture can be ignited by friction. Option D: Gas is easily ignited " B 297 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C Question about this molecule: How is the ignitability of this molecule Option A: It is easily ignited Option B: Gas is easily ignited Option C: It is easily ignited in air Option D: The mixture can be ignited by friction. " A 23953 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [SiH4] Question about this molecule: How is the ignitability of this molecule Option A: The mixture can be ignited by friction. Option B: Gas is easily ignited Option C: It is easily ignited Option D: It is easily ignited in air " D 7845 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC=C Question about this molecule: How is the ignitability of this molecule Option A: It is easily ignited in air Option B: Gas is easily ignited Option C: It is easily ignited Option D: The mixture can be ignited by friction. " C 674 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC Question about this molecule: How is the ignitability of this molecule Option A: It is easily ignited in air Option B: The mixture can be ignited by friction. Option C: It is easily ignited Option D: Gas is easily ignited " D 61055 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1COCCN1CCCN Question about this molecule: How is the ignitability of this molecule Option A: Burns but may require some effort to ignite Option B: Burns, but requires some effort to ignite Option C: It may require some effort to ignite. Option D: It may take some effort to ignite. " B 5054 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC(=C1)O)O Question about this molecule: How is the ignitability of this molecule Option A: Burns although ignition is difficult Option B: It may require some effort to ignite. Option C: Burns, but requires some effort to ignite Option D: Burns but may require some effort to ignite " A 8252 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC=C Question about this molecule: How is the ignitability of this molecule Option A: It is easily ignited Option B: It is easily ignited in air Option C: Gas is easily ignited Option D: The mixture can be ignited by friction. " A 6324 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC Question about this molecule: How is the ignitability of this molecule Option A: It is easily ignited in air Option B: It is easily ignited Option C: The mixture can be ignited by friction. Option D: Gas is easily ignited " B 12389 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCCC Question about this molecule: How is the ignitability of this molecule Option A: It may take some effort to ignite. Option B: It may require some effort to ignite. Option C: Must be preheated before ignition can occur Option D: It must be heated before ignition may occur easily. " C 7434 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C=C1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: How is the ignitability of this molecule Option A: It may take some effort to ignite. Option B: Burns, but requires some effort to ignite Option C: It may require some effort to ignite. Option D: Burns but may require some effort to ignite " D 4499 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC Question about this molecule: How is the ignitability of this molecule Option A: Burns but may require some effort to ignite Option B: If exposed to air or moisture, it may become hot enough to ignite. Option C: Burns, but requires some effort to ignite Option D: It prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. " D 3118 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)SCCSCC Question about this molecule: How is the ignitability of this molecule Option A: It may require some effort to ignite. Option B: It may take some effort to ignite. Option C: It may be difficult to ignite. Option D: It does not ignite easily. " D 6360 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C Question about this molecule: How is the ignitability of this molecule Option A: Gas is easily ignited Option B: It is easily ignited in air Option C: The mixture can be ignited by friction. Option D: It is easily ignited " D 784 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OO Question about this molecule: How is the ignitability of this molecule Option A: It must be heated before ignition may occur easily. Option B: It may require some effort to ignite. Option C: It will accelerate the burning of combustible materials. Option D: Contact with combustible materials may result in spontaneous ignition. " D 5565 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CNCCNCCN)N Question about this molecule: How is the ignitability of this molecule Option A: It may be difficult to ignite. Option B: Burns but may require some effort to ignite Option C: It may require some effort to ignite. Option D: It may take some effort to ignite. " A 6129 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC(=O)OC1=CC=CC2=CC=CC=C21 Question about this molecule: How is the ignitability of this molecule Option A: It may take some effort to ignite. Option B: It may be difficult to ignite. Option C: Burns but may require some effort to ignite Option D: It may require some effort to ignite. " B 7843 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC Question about this molecule: How is the ignitability of this molecule Option A: It is easily ignited in air Option B: Gas is easily ignited Option C: The mixture can be ignited by friction. Option D: It is easily ignited " D 23668193 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: N(=O)[O-].[Na+] Question about this molecule: How is the ignitability of this molecule Option A: If exposed to air or moisture, it may become hot enough to ignite. Option B: Must be preheated before ignition can occur Option C: An explosion may result if large quantities are involved in a fire or if the combustible material is finely divided. Option D: It must be heated before ignition may occur easily. " C 444266 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=C\\C(=O)O)\\C(=O)O Question about this molecule: How is the ignitability of this molecule Option A: Burns but may require some effort to ignite Option B: It may require some effort to ignite. Option C: It may take some effort to ignite. Option D: It may be difficult to ignite. " C 996 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)O Question about this molecule: How is the ignitability of this molecule Option A: It must be heated before ignition may occur easily. Option B: It may take some effort to ignite. Option C: It may require some effort to ignite. Option D: Must be preheated before ignition can occur " A 3289 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCSP(=O)(OCC)SCCC Question about this molecule: How is the ignitability of this molecule Option A: It may be difficult to ignite. Option B: It may take some effort to ignite. Option C: It may require some effort to ignite. Option D: Burns but may require some effort to ignite " C 22985 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [NH4+].[N+](=O)([O-])[O-] Question about this molecule: How is the ignitability of this molecule Option A: Contact with combustible materials may result in spontaneous ignition. Option B: It must be heated before ignition may occur easily. Option C: It may require some effort to ignite. Option D: It will accelerate the burning of combustible materials. " D 935 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Ni] Question about this molecule: How is the ignitability of this molecule Option A: It may require some effort to ignite. Option B: It must be heated before ignition may occur easily. Option C: It may take some effort to ignite. Option D: If exposed to air or moisture, it may become hot enough to ignite. " D 753 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(CO)O)O Question about this molecule: How is the ignitability of this molecule Option A: It may require some effort to ignite. Option B: It may take some effort to ignite. Option C: Burns but may require some effort to ignite Option D: It may be difficult to ignite. " A 104770 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]Cl(=O)=O Question about this molecule: How is the ignitability of this molecule Option A: It is easily ignited Option B: The mixture can be ignited by friction. Option C: It is easily ignited in air Option D: Gas is easily ignited " B 6327 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCl Question about this molecule: How is the ignitability of this molecule Option A: Gas is easily ignited Option B: It is easily ignited in air Option C: The mixture can be ignited by friction. Option D: It is easily ignited " D 6351 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC1 Question about this molecule: How is the ignitability of this molecule Option A: The mixture can be ignited by friction. Option B: It is easily ignited Option C: Gas is easily ignited Option D: It is easily ignited in air " B 6115 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)N Question about this molecule: How is the ignitability of this molecule Option A: Gas is easily ignited Option B: It ignites readily Option C: It is easily ignited in air Option D: It is easily ignited " B 6329 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN Question about this molecule: How is the ignitability of this molecule Option A: It is easily ignited Option B: It is easily ignited in air Option C: The mixture can be ignited by friction. Option D: Gas is easily ignited " A 281 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C-]#[O+] Question about this molecule: How is the ignitability of this molecule Option A: The mixture can be ignited by friction. Option B: It is easily ignited Option C: Gas is easily ignited Option D: It is easily ignited in air " B 783 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [HH] Question about this molecule: How is the ignitability of this molecule Option A: The mixture can be ignited by friction. Option B: It is easily ignited Option C: Gas is easily ignited Option D: It is easily ignited in air " B 51040684 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC1=C2C(=C(C=C1O)O)C(=O)C[C@H](O2)C3=C(C=CC(=C3)C(C)(C)C=C)O)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against HIV-1 integrase. Option B: It exhibits inhibitory activity against tyrosinase. Option C: It exhibits inhibitory activity against NF-kappaB. Option D: It exhibits inhibitory activity against chymotrypsin. " B 193876 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC1=C(C=C(C2=C1O[C@@H]([C@H](C2=O)O)C3=CC=C(C=C3)O)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibition of intestinal P-glycoprotein. Option B: It exhibits inhibitory activity against HIV protease. Option C: It exhibits inhibitory activity towards HIV-1 protease. Option D: It is found to inhibit dimerization of HIV-1 protease subunits. " A 10316213 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C(=C(C=C1C2=CC(=C(C=C2)O)O)O)C3=CC(=C(C=C3)O)O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against alpha-glucosidase. Option B: It exhibits inhibitory activity against aldose reductase. Option C: It exhibits inhibitory activity against alpha-amylase. Option D: It exhibits inhibitory activity against HIV protease. " A 53262758 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C(=C(C=C1C2=CC=C(C=C2)O)O)C3=CC(=C(C=C3)O)O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against alpha-amylase. Option B: It exhibits inhibitory activity against aldose reductase. Option C: It exhibits inhibitory activity against HIV protease. Option D: It exhibits inhibitory activity against alpha-glucosidase. " D 11377137 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC[C@H]([C@H]1CC[C@@]2([C@@]1(CCC3=C2CC[C@@H]4[C@@]3(CC[C@H](C4(C)C)OC(=O)C)C)C)C)C(=O)O[C@H]5[C@@H]([C@H]([C@@H](CO5)O)O)O)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against COX-2. Option B: It exhibits inhibitory activity against COX-1 and COX-2. Option C: It exhibits inhibitory activity against COX-2 and 5-lipooxygenase. Option D: It exhibits inhibitory activity towards cyclooxygenases (COX-1 and COX-2). " B 5281656 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C2C(=C1O)C(=O)C3=CC(=C(C=C3O2)O)O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against tyrosinase. Option B: It exhibits inhibitory activity against protein kinase C. Option C: It exhibits inhibitory activity against chymotrypsin. Option D: It exhibits inhibitory activity against NF-kappaB. " B 53262748 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C(=C(C=C1C2=CC=C(C=C2)O)O)C3=CC=C(C=C3)O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against alpha-glucosidase. Option B: It exhibits inhibitory activity against alpha-amylase. Option C: It exhibits inhibitory activity against HIV protease. Option D: It exhibits inhibitory activity against aldose reductase. " A 21579665 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C(=C(C(=C3O2)OC)OC)O)O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory effect on the tube-like formation of human umbilical vein endothelial cells (HUVECs). Option B: It exhibits inhibitory activity on PAR-1, a thrombin receptor expressed on platelets. Option C: It exhibits inhibitory activity on ADP-mediated platelet activation and aggregation. Option D: It exhibits inhibitory activity on proliferation of human peripheral blood lymphocytes. " A 44597554 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1C/C=C\\C(=O)[C@H]([C@H](C/C=C/C2=C(C(=CC(=C2)O)O)C(=O)O1)O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against chymotrypsin. Option B: It exhibits inhibitory activity against NF-kappaB. Option C: It exhibits inhibitory activity against platelet aggregation. Option D: It exhibits inhibitory activity against DNA polymerase and platelet aggregation. " B 56600472 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC/C=C\\C/C=C\\CCCCCCCC(=O)OCCCC1=CC2=C(C=C1)OC(=C2)C3=CC4=C(C=C3)OCO4 Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against acetylcholinesterase. Option B: Ethion is an organophosphate insecticide with inhibitory activity towards the enzyme acetylcholinesterase (EC 3.1.1.7). Option C: It inhibits acetylcholinesterase, which breaks down acetylcholine to terminate signals from receptors. Option D: It possesses significant inhibitory activity against acetylcholinesterase enzyme (EC 3.1.1.7). " A 54712103 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C=C(\\C)/[C@@H]1C=C[C@@H]2C[C@@H](C[C@@H]([C@H]2[C@@H]1/C(=C/3\\C(=O)[C@H](NC3=O)C[C@](C)(C(=O)OC)O)/O)C)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against NF-kappaB. Option B: It exhibits inhibitory activity against chymotrypsin. Option C: It exhibits inhibitory activity against chemokine receptor CCR-5. Option D: It exhibits inhibitory activity against platelet aggregation. " C 51040900 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC1=C(C(=CC=C1)[C@@H]2CC(=O)C3=C(O2)C4=C(C=C3O)OC(C=C4)(C)C)O)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against chymotrypsin. Option B: It exhibits inhibitory activity against HIV-1 integrase. Option C: It exhibits inhibitory activity against NF-kappaB. Option D: It exhibits inhibitory activity against tyrosinase. " D 10371340 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C2=C(C(=C1O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)COC(=O)C4=CC=C(C=C4)O)O)O)O)C)O[C@@H](CC2=O)C5=C(C=CC(=C5)O)O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against aldose reductase. Option B: It exhibits inhibitory activity against HIV protease. Option C: It exhibits inhibitory activity against alpha-amylase. Option D: It exhibits inhibitory activity against alpha-glucosidase. " A 11158025 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)O[C@@H]1CC[C@]2([C@H](C1(C)C)CCC3=C2CC[C@]4([C@]3(CC[C@@H]4[C@@H](C/C=C/C(C)(C)O)C(=O)O[C@H]5[C@@H]([C@H]([C@@H](CO5)O)O)O)C)C)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against COX-2. Option B: It exhibits inhibitory activity towards cyclooxygenases (COX-1 and COX-2). Option C: It exhibits inhibitory activity against COX-1 and COX-2. Option D: It exhibits inhibitory activity against COX-2 and 5-lipooxygenase. " C 51040899 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC1=C(C(=CC=C1)[C@@H]2CC(=O)C3=C(C=C(C(=C3O2)CC=C(C)C)O)O)O)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against chymotrypsin. Option B: It exhibits inhibitory activity against NF-kappaB. Option C: It exhibits inhibitory activity against tyrosinase. Option D: It exhibits inhibitory activity against HIV-1 integrase. " C 56598866 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC/C=C\\C/C=C\\CCCCCCCC(=O)OCCCC1=CC2=C(C(=C1)OC)OC(=C2)C3=CC4=C(C=C3)OCO4 Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against acetylcholinesterase. Option B: It possesses significant inhibitory activity against acetylcholinesterase enzyme (EC 3.1.1.7). Option C: Ethion is an organophosphate insecticide with inhibitory activity towards the enzyme acetylcholinesterase (EC 3.1.1.7). Option D: It inhibits acetylcholinesterase, which breaks down acetylcholine to terminate signals from receptors. " A 24899923 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C(=C\\C(=O)O)/CC[C@@H]1[C@]2(CCC[C@@]([C@@H]2CC[C@@]1(C)O)(C)CO)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against COX-1 and COX-2. Option B: It exhibits inhibitory activity against cyclooxygenase 1 and 2. Option C: It exhibits inhibitory activity towards cyclooxygenases (COX-1 and COX-2). Option D: It exhibits inhibitory activity against COX-2 and 5-lipooxygenase. " C 5282054 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C=C/C/C=C/CCC(=O)[C@@H]1[C@@H](O1)C(=O)N Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits the biosynthesis of several lipids by interfering with enzyme function. Option B: It exhibits inhibitory activity on a process mediated by H2O2 produced in the oxidation of amines. Option C: It exhibits inhibitory activity against the production of interleukin 1-beta from induced inflammasomes. Option D: It exhibits inhibitory activity on ADP-mediated platelet activation and aggregation. " A 6234 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@H](C(=O)NO1)N Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It acts as a pharmacoenhancer in treatment of HIV-1 by inhibiting P450 enzymes that metabolise other medications. Option B: It competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity. Option C: It inhibits urate crystal deposition, possibly by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Option D: It interferes with bacterial cell wall synthesis in the cytoplasm by competitive inhibition of L-alanine racemase and D-alanine--D-alanine ligase. " D 7690 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC=C(C=C1)CC(=O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits AdoMet-mediated processes. Option B: It inhibits GABA. Option C: It inhibits photosynthesis in susceptible species. Option D: It inhibits the germination of cress and lettuce seeds. " D 439501 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@H]2C[C@H]([C@@]3([C@@H]4[C@@H](CC[C@@]3(C2)O)[C@]5(CC[C@@H]([C@]5(C[C@H]4O)C)C6=CC(=O)OC6)O)CO)O)O)O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). Option B: It inhibits the synthesis of DNA. Option C: It inhibits the synthesis of DNA and RNA. Option D: It inhibits the Na-K-ATPase membrane pump. " A 51041987 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@@H]([C@H](OC2=C1C(=C(C(=C2)O)[C@H]3[C@@H]([C@H](OC4=C3C=CC(=C4)O)C5=CC(=C(C=C5)O)O)O)O)C6=CC(=C(C(=C6)O)O)O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against alpha-amylase. Option B: It exhibits inhibitory activity against aldose reductase. Option C: It exhibits inhibitory activity against alpha-glucosidase. Option D: It exhibits inhibitory activity against HIV protease. " A 57390614 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC2=CC(=C3C(=C2)OC(=C(C3=O)O[C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)O)C5=CC=C(C=C5)O)O)O)O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against topoisomerase I and II. Option B: It exhibits inhibitory activity against topoisomerase II. Option C: It exhibits inhibitory activity against chymotrypsin. Option D: It exhibits inhibitory activity against topoisomerase I. " D 11274280 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(C=C4)O)O)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)COC(=O)/C=C/C6=CC(=C(C=C6)O)O)O)O)O)O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against chymotrypsin. Option B: It exhibits inhibitory activity against NF-kappaB. Option C: It exhibits inhibitory activity against tyrosinase. Option D: It exhibits inhibitory activity against angiotensin-converting enzyme. " D 6253 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits the synthesis of DNA and RNA. Option B: It inhibits GABA. Option C: It inhibits the enzyme aromatase. Option D: It inhibits the synthesis of DNA. " D 5289418 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CNC(=C1CCC(=O)O)/C=C\\2/C3=CC=CC=C3NC2=O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It is an ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1. Option B: It has been found to inhibit insulin receptor tyrosine kinase activity and insulin-stimulated glucose oxidation. Option C: It exhibits inhibitory activity on ADP-mediated platelet activation and aggregation. Option D: It exhibits inhibitory activity on PAR-1, a thrombin receptor expressed on platelets. " A 50900934 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCC(=O)O[C@H]1[C@@H](O[C@H]([C@@H]([C@@H]1O)OC(=O)/C=C/C2=CC=CC=C2)O[C@H]3[C@@H](O[C@H]([C@@H]([C@@H]3OC(=O)CCCCCCCCC)O)O[C@H]4[C@@H](O[C@@H]5[C@@H]([C@@H]4O)OC(=O)CCCCCCCCC[C@@H](O[C@H]6[C@H](O5)[C@H]([C@H]([C@H](O6)C)O)O)CCCCC)C)C)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against COX-2 and 5-lipooxygenase. Option B: It exhibits inhibitory activity against COX-2. Option C: It exhibits inhibitory activity against COX-1 and COX-2. Option D: It exhibits inhibitory activity towards cyclooxygenases (COX-1 and COX-2). " C 70697917 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOC(C)(C)[C@@H](COC1=C2C(=C(C3=C1OC(=O)C=C3)OC)C=CO2)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity towards cyclooxygenases (COX-1 and COX-2). Option B: It exhibits inhibitory activity against COX-2 and 5-lipooxygenase. Option C: It exhibits inhibitory activity against cyclooxygenase 1 and 2. Option D: It exhibits inhibitory activity against COX-1 and COX-2. " B 51041986 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C=C(C=C1O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)[C@@H]3[C@H](CC4=C(O3)C=C(C=C4)O)O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against alpha-amylase. Option B: It exhibits inhibitory activity against aldose reductase. Option C: It exhibits inhibitory activity against alpha-glucosidase. Option D: It exhibits inhibitory activity against HIV protease. " A 3619 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)OCOC(C1=CC2=CC=CC=C2C=C1)P(=O)(OCOC(=O)C)OCOC(=O)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity on PAR-1, a thrombin receptor expressed on platelets. Option B: It has been found to inhibit insulin receptor tyrosine kinase activity and insulin-stimulated glucose oxidation. Option C: It exhibits inhibitory activity on ADP-mediated platelet activation and aggregation. Option D: It inhibits excitatory neurotransmission through actions on kainate and AMPA receptors. " B 57397583 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@H]([C@H](O[C@H]2OC3=C(OC4=CC(=CC(=C4C3=O)O)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)O)O)O)C6=CC=C(C=C6)O)CO)O)O)O)O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against chymotrypsin. Option B: It exhibits inhibitory activity against topoisomerase I. Option C: It exhibits inhibitory activity against topoisomerase I and II. Option D: It exhibits inhibitory activity against topoisomerase II. " B 56600473 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCC/C=C\\CCCCCCCC(=O)OCCCC1=CC2=C(C=C1)OC(=C2)C3=CC4=C(C=C3)OCO4 Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It possesses significant inhibitory activity against acetylcholinesterase enzyme (EC 3.1.1.7). Option B: Ethion is an organophosphate insecticide with inhibitory activity towards the enzyme acetylcholinesterase (EC 3.1.1.7). Option C: It inhibits acetylcholinesterase, which breaks down acetylcholine to terminate signals from receptors. Option D: It exhibits inhibitory activity against acetylcholinesterase. " D 10393120 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCN2CC[C@H]3C(=C[C@@](CC/C=C\\C1)([C@H]4[C@]3(C2)C[C@H]/5N4CCCC/C=C5)O)C6=NC=CC7=C6NC8=C7C=C(C=C8)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against tyrosinase. Option B: It exhibits inhibitory activity against protein kinase C. Option C: It exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26). Option D: It exhibits inhibitory activity against chymotrypsin. " C 5793932 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=O)/C(=C/C3=CC(=C(C=C3)O)O)/O2 Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It shows inhibitory activity against several isoforms of the histone deacetylase complex (HDAC). Option B: It exhibits inhibitory activity against the production of interleukin 1-beta from induced inflammasomes. Option C: It exhibits inhibitory activity on ADP-mediated platelet activation and aggregation. Option D: It exhibits inhibitory activity on PAR-1, a thrombin receptor expressed on platelets. " A 5270765 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCN2CC[C@H]3C(=C[C@@](CC/C=C\\C1)([C@H]4[C@]3(C2)C[C@H]/5N4CCCC/C=C5)O)C6=NC=CC7=C6NC8=C7C=CC=C8O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against protein kinase C. Option B: It exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26). Option C: It exhibits inhibitory activity against tyrosinase. Option D: It exhibits inhibitory activity against chymotrypsin. " B 51042196 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@@H]([C@H](OC2=C1C(=CC(=C2[C@@H]3[C@H]([C@H](OC4=C3C=CC(=C4)O)C5=CC(=C(C(=C5)O)O)O)O)O)O)C6=CC(=C(C=C6)O)O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against aldose reductase. Option B: It exhibits inhibitory activity against HIV protease. Option C: It exhibits inhibitory activity against alpha-amylase. Option D: It exhibits inhibitory activity against alpha-glucosidase. " C 6440728 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)[C@H](/C(=C\\C1=C(C=C(C=C1)Cl)Cl)/N2C=NC=N2)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It is an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor. Option B: It has a role as an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor and an antifungal agrochemical. Option C: It has a role as an EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor and an antifungal agrochemical. Option D: It inhibits dopa decarboxylase and depletes animal tissues of norepinephrine. " B 44584408 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC/C=C\\C/C=C\\C/C=C\\CC#CCCCCC(=O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against cyclooxygenase 1 and 2. Option B: It exhibits inhibitory activity against COX-2 and 5-lipooxygenase. Option C: It exhibits inhibitory activity towards cyclooxygenases (COX-1 and COX-2). Option D: It exhibits inhibitory activity against arachidonate 15-lipoxygenase. " D 44468216 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C2C(=NC=NN2C(=C1)[C@]3([C@@H]([C@@H]([C@H](O3)CO)O)O)C#N)N Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits a broad range of inhibitory activity against various RNA viruses including HCV, parainfluenza and SARS-CoV. Option B: It acts as a pharmacoenhancer in treatment of HIV-1 by inhibiting P450 enzymes that metabolise other medications. Option C: It exhibits inhibitory activity on muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. Option D: It inhibits excitatory neurotransmission through actions on kainate and AMPA receptors. " A 162243 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](CCCN(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@H]4[C@@]3(CCCC4)C)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity on muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. Option B: It inhibits sitosterol-to-cholesterol conversion in Caenorhabditis elegans. Option C: It inhibits excitatory neurotransmission through actions on kainate and AMPA receptors. Option D: It exhibits inhibitory activity on ADP-mediated platelet activation and aggregation. " B 135398517 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NC2=C(C=CC=C2O)C(=O)N1 Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory effect on platelet aggregation. Option B: It exhibits inhibitory activity against DNA polymerase and platelet aggregation. Option C: It has been shown to exhibit inhibitory activity against poly(ADP-ribose) polymerase. Option D: It exhibits inhibitory activity against platelet aggregation. " C 10485148 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=C(OC4=CC(=CC(=C4C3=O)O)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)O)O)O)C6=CC=C(C=C6)O)CO)O)O)O)O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against chymotrypsin. Option B: It exhibits inhibitory activity against topoisomerase I and II. Option C: It exhibits inhibitory activity against topoisomerase I. Option D: It exhibits inhibitory activity against topoisomerase II. " C 10992937 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1C2=C(C3=C(C=C(C=C3)O)OC2=O)O[C@]1(C)CC/C=C(\\C)/CC(=O)C=C(C)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory effects on production of nitric oxide. Option B: It exhibits inhibitory effect on the production of nitric oxide (NO). Option C: It exhibits inhibitory activity on nitric oxide production. Option D: It exhibits inhibitory activity against production of nitric oxide (NO). " D 11361458 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C2=C(C3=C(C=C(C=C3)O)OC2=O)O[C@]1(C)CC/C=C(\\C)/CC(=O)C=C(C)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against production of nitric oxide (NO). Option B: It exhibits inhibitory effect on the production of nitric oxide (NO). Option C: It exhibits inhibitory effects on production of nitric oxide. Option D: It exhibits inhibitory activity on nitric oxide production. " B 5315394 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC1=C(C(=CC(=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O)CC(C(=C)C)O)O)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against chymotrypsin. Option B: It exhibits inhibitory activity against DNA polymerase and platelet aggregation. Option C: It exhibits inhibitory effect on platelet aggregation. Option D: It exhibits inhibitory activity against platelet aggregation. " D 464001 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC12C3=C(C(=C(C=C3C=O)OC)O)OC(O1)(C4=C(C(=C(C=C4C2=O)OC)O)O)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against HIV-1 RNAse H. Option B: It exhibits inhibitory activity towards HIV-1 protease. Option C: It exhibits inhibitory activity against HIV-1 integrase. Option D: It exhibits inhibitory activity against HIV protease. " C 9548904 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@@H]([C@H](O[C@H]1C2=CC(=C(C=C2)O)OC)C3=CC(=C(C=C3)OC)OC)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory effect on the production of nitric oxide (NO). Option B: It exhibits inhibitory activity on nitric oxide production. Option C: It exhibits inhibitory activity against production of nitric oxide (NO). Option D: It exhibits inhibitory effects on production of nitric oxide. " C 156391 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It works by inhibiting both the COX-1 and COX-2 enzymes. Option B: It exhibits inhibitory activity against COX-2. Option C: It exhibits inhibitory activity against COX-1 and COX-2. Option D: It exhibits inhibitory activity against COX-2 and 5-lipooxygenase. " A 5320053 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC1=C(C=CC(=C1)C2=COC3=C(C2=O)C=CC(=C3)O)O)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory effect on platelet aggregation. Option B: It exhibits inhibitory activity against DNA polymerase and platelet aggregation. Option C: It exhibits inhibitory activity against platelet aggregation. Option D: It exhibits inhibitory activity against chymotrypsin. " B 54676254 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C1=C(C2=C(C=C(C=C2)O)OC1=O)O)/C(=C/C/C=C(\\C)/CC(=O)C=C(C)C)/C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory effect on the production of nitric oxide (NO). Option B: It exhibits inhibitory activity on nitric oxide production. Option C: It exhibits inhibitory activity against production of nitric oxide (NO). Option D: It exhibits inhibitory effects on production of nitric oxide. " A 10047038 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1C2=C(C3=C(C=C(C=C3)OC)OC2=O)O[C@]1(C)CC/C=C(\\C)/CC4=CC(=CO4)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity on nitric oxide production. Option B: It exhibits inhibitory effects on production of nitric oxide. Option C: It exhibits inhibitory activity against production of nitric oxide (NO). Option D: It exhibits inhibitory effect on the production of nitric oxide (NO). " C 8298 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1CC(CC(C1)(C)C)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits HMG-Coenzyme A reductase inhibitory activity. Option B: It exhibits competitive inhibitory activity on HMG-CoA reductase. Option C: It exhibits competitive inhibitory activity on tyrosinase in melanocytes. Option D: It exhibits inhibitory activity against HMG-CoA reductase (EC 1.1.1.34/EC 1.1.1.88). " D 41632 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1C(=O)NC2=CC(=CC=C2)OC(C)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It has a role as an EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor and an antifungal agrochemical. Option B: It is an EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor. Option C: It has a role as an EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor. Option D: It inhibits carbonic anhydrase in the ciliary processes of the eye. " C 16760394 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](CCC(=O)OC)NC(=O)[C@H](CC(=O)OC)NC(=O)OCC1=CC=CC=C1 Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against tyrosinase. Option B: It is a specific, irreversible caspase-3 inhibitor. Option C: It exhibits inhibitory activity against chymotrypsin. Option D: It exhibits inhibitory activity against caspase-1. " B 11522311 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C(=C(C=C1)/C=C/C2=CC(=CC(=C2)OC)O)OC)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory effects on production of nitric oxide. Option B: It exhibits inhibitory activity on nitric oxide production. Option C: It has been shown to exhibit inhibitory activity against nitric oxide production. Option D: It exhibits inhibitory activity against production of nitric oxide (NO). " A 24850616 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC=C(C=C1)CO[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)C(=O)O)O)O)O)O)OC(=O)C4=CC=CC=C4)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against platelet aggregation. Option B: It exhibits inhibitory activity against NF-kappaB. Option C: It exhibits inhibitory activity against DNA polymerase and platelet aggregation. Option D: It exhibits inhibitory activity against chymotrypsin. " D 6509753 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCN2CC[C@H]3C(=C[C@@](CC/C=C\\C1)([C@H]4[C@]3(C2)C[C@H]/5N4CCCC/C=C5)O)C6=NC=CC7=C6NC8=CC=CC=C78 Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against protein kinase C. Option B: It exhibits inhibitory activity against tyrosinase. Option C: It exhibits inhibitory activity against chymotrypsin. Option D: It exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26). " D 90590 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CO1)C(=O)NC2=CC=CC=C2 Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits carbonic anhydrase in the ciliary processes of the eye. Option B: It is an EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor. Option C: It has a role as an EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor. Option D: It has a role as an EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor and an antifungal agrochemical. " C 11507326 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC(=CC(=C1)O)/C=C/C2=C(C(=CC=C2)O)OC Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory effects on production of nitric oxide. Option B: It exhibits inhibitory activity on nitric oxide production. Option C: It has been shown to exhibit inhibitory activity against nitric oxide production. Option D: It exhibits inhibitory activity against production of nitric oxide (NO). " B 3286 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)SCSP(=S)(OCC)OCC Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against acetylcholinesterase. Option B: It possesses significant inhibitory activity against acetylcholinesterase enzyme (EC 3.1.1.7). Option C: It inhibits acetylcholinesterase, which breaks down acetylcholine to terminate signals from receptors. Option D: Ethion is an organophosphate insecticide with inhibitory activity towards the enzyme acetylcholinesterase (EC 3.1.1.7). " D 135526609 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=C1[C@H](C[C@@H]([C@H]1CO)O)N2C=NC3=C2N=C(NC3=O)N.O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits excitatory neurotransmission through actions on kainate and AMPA receptors. Option B: It acts as a pharmacoenhancer in treatment of HIV-1 by inhibiting P450 enzymes that metabolise other medications. Option C: It inhibits urate crystal deposition, possibly by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Option D: It competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity. " D 10343070 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC1=C(C(=CC(=C1)C2=C(C(=O)C3=C(O2)C=C(C(=C3O)CC=C(C)C)O)O)O)O)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against tyrosinase. Option B: It exhibits inhibitory activity against phospholipase A2 and tyrosinase. Option C: It exhibits inhibitory activity against NF-kappaB. Option D: It exhibits inhibitory activity against chymotrypsin. " B 70697859 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC(=CC(=C1OC)OC)CO[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against DNA polymerase and platelet aggregation. Option B: It exhibits inhibitory activity against chymotrypsin. Option C: It exhibits inhibitory activity against NF-kappaB. Option D: It exhibits inhibitory activity against platelet aggregation. " B 44179301 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@]12[C@@H]3[C@@H]([C@@H]4[C@]5(O4)[C@H](OC(=O)C=C5[C@]3([C@H]6[C@@H]([C@@H]1O)O6)C)C=C)OC2=O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against platelet aggregation. Option B: It exhibits inhibitory activity against chymotrypsin. Option C: It exhibits inhibitory activity against NF-kappaB. Option D: It exhibits inhibitory activity against activator protein 1 (AP-1). " D 16095400 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C=C(C(=N1)C(F)F)C(=O)NC2=CC=CC=C2C3=CC(=C(C(=C3)F)F)F Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It has a role as an EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor. Option B: It inhibits carbonic anhydrase in the ciliary processes of the eye. Option C: It has a role as an EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor and an antifungal agrochemical. Option D: It is an EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor. " D 91673 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC1COC(O1)(CN2C=NC=N2)C3=C(C=C(C=C3)Cl)Cl Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits dopa decarboxylase and depletes animal tissues of norepinephrine. Option B: It is an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor. Option C: It has a role as an EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor and an antifungal agrochemical. Option D: It has a role as an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor and an antifungal agrochemical. " B 86211 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C1CCC(C1(CN2C=NC=N2)O)CC3=CC=C(C=C3)Cl Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It is an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor. Option B: It inhibits dopa decarboxylase and depletes animal tissues of norepinephrine. Option C: It has a role as an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor and an antifungal agrochemical. Option D: It has a role as an EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor and an antifungal agrochemical. " A 86210 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(CCC(C1(CN2C=NC=N2)O)CC3=CC=C(C=C3)Cl)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It is an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor. Option B: It has a role as an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor and an antifungal agrochemical. Option C: It has a role as an EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor and an antifungal agrochemical. Option D: It inhibits dopa decarboxylase and depletes animal tissues of norepinephrine. " A 54581281 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[C@@H]1[C@]23[C@H](O2)[C@@H]4[C@H]5[C@]([C@H]([C@@H]6[C@H]([C@@]5(C3=CC(=O)O1)C)O6)O)(C(=O)O4)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against chymotrypsin. Option B: It exhibits inhibitory activity against platelet aggregation. Option C: It exhibits inhibitory activity against activator protein 1 (AP-1). Option D: It exhibits inhibitory activity against NF-kappaB. " C 11434448 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C=C(C(=N1)C(F)F)C(=O)NC2=C(C=C(C=C2)F)C3=CC(=C(C=C3)Cl)Cl Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It is an EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor. Option B: It has a role as an EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor and an antifungal agrochemical. Option C: It inhibits carbonic anhydrase in the ciliary processes of the eye. Option D: It has a role as an EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor. " A 70697869 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C1=C(C2=CC=CC=C2C(=O)C1=O)[O-])C3=C(C4=CC=CC=C4C(=O)C3=O)[O-].[Na+].[Na+] Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against COX-2 and 5-lipooxygenase. Option B: It exhibits inhibitory activity towards cyclooxygenases (COX-1 and COX-2). Option C: It exhibits inhibitory activity against COX-2. Option D: It exhibits inhibitory activity against COX-1 and COX-2. " C 46224603 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]2[C@H](OC([C@H]([C@H]2O)O)O)CO)O)O)O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It acts as a pharmacoenhancer in treatment of HIV-1 by inhibiting P450 enzymes that metabolise other medications. Option B: It has shown inhibitory activity against biofilm formation of the dental bacterium Streptococcus mutans. Option C: It can inhibit Leishmania major glycoinositol phospholipid binding by sera from patients with acute cutaneous leishmaniasis. Option D: It inhibits urate crystal deposition, possibly by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. " C 469 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(C(=O)O)N)CC(=O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits excitatory neurotransmission through actions on kainate and AMPA receptors. Option B: It inhibits urate crystal deposition, possibly by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Option C: It exhibits inhibitory activity on the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. Option D: It inhibits the production of kynurenic acid in brain tissue slices. " D 6604200 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C(=O)NC(=O)N1/N=C/C2=CC=C(O2)[N+](=O)[O-] Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits protein, RNA, and DNA synthesis. Option B: It inhibits the synthesis of DNA. Option C: It inhibits the synthesis of DNA and RNA. Option D: It inhibits the citric acid cycle as well as synthesis of DNA, RNA, and protein. " D 2719 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits ACE. Option B: It inhibits heme oxygenase 1. Option C: It inhibits heme polymerase activity. Option D: It inhibits GABA. " C 1549008 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)C#C/C=C/CN(C)CC1=CC=CC2=CC=CC=C21 Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits urate crystal deposition, possibly by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Option B: It inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epoxidase), an enzyme that is part of the fungal cell wall synthesis pathway. Option C: It inhibits excitatory neurotransmission through actions on kainate and AMPA receptors. Option D: It exhibits inhibitory activity on muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. " B 4760 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2C(=O)C3=CC=CC=C3C2=O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). Option B: It inhibits vitamin K reductase. Option C: It inhibits aberrant cell growth and proliferation by targeting IDH1. Option D: It inhibits GABA. " A 6322 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C[C@@H](C(=O)O)N)CN=C(N)N Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits ergosterol synthesis and increases fungal cellular permeability. Option B: It partially reduces arginine-induced protein synthesis by inhibiting mTOR. Option C: It inhibits excitatory neurotransmission through actions on kainate and AMPA receptors. Option D: It inhibits urate crystal deposition, possibly by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. " B 4929 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NC1=NC(=NC(=N1)SC)NC(C)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits the synthesis of DNA and RNA. Option B: It inhibits GABA. Option C: It inhibits photosynthesis in susceptible species. Option D: It inhibits the synthesis of DNA. " C 6178111 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)N=C(N)/N=C(\\N)/NC1=CC=C(C=C1)Cl Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits the production of kynurenic acid in brain tissue slices. Option B: It inhibits urate crystal deposition, possibly by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Option C: It inhibits carbonic anhydrase in the ciliary processes of the eye. Option D: It inhibits the enzyme dihydrofolate reductase, which is involved in the reproduction of the parasite. " D 41867 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits nucleic acid (DNA and RNA) and protein synthesis by forming complexes with DNA and inhibiting topoisomerase II activity. Option B: It inhibits urate crystal deposition, possibly by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Option C: It inhibits excitatory neurotransmission through actions on kainate and AMPA receptors. Option D: It exhibits inhibitory activity on ADP-mediated platelet activation and aggregation. " A 4095 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2 Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It dampens a major excitatory pain pathway within the central nervous system by inhibiting the NMDA receptor. Option B: It exhibits inhibitory activity on muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. Option C: It inhibits excitatory neurotransmission through actions on kainate and AMPA receptors. Option D: It exhibits inhibitory activity on the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. " A 2833 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity on ADP-mediated platelet activation and aggregation. Option B: It inhibits urate crystal deposition, possibly by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Option C: It exhibits inhibitory activity on muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. Option D: It inhibits excitatory neurotransmission through actions on kainate and AMPA receptors. " B 6579 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC(=O)N Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It shows inhibitory activity against several isoforms of the histone deacetylase complex (HDAC). Option B: It inhibits the biosynthesis of several lipids by interfering with enzyme function. Option C: It exhibits inhibitory activity against the production of interleukin 1-beta from induced inflammasomes. Option D: It can bind to sulfhydryl groups and inactivate proteins/enzymes involved in DNA repair and other critical cell functions. " D 115224 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CSC(=NC#N)N1CC2=CN=C(C=C2)Cl Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity on muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. Option B: It inhibits acetylcholinesterase, which breaks down acetylcholine to terminate signals from receptors. Option C: It inhibits excitatory neurotransmission through actions on kainate and AMPA receptors. Option D: It inhibits urate crystal deposition, possibly by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. " B 107807 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC[C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). Option B: It is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). Option C: It exhibits inhibitory activity on muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. Option D: It inhibits excitatory neurotransmission through actions on kainate and AMPA receptors. " B 38853 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)O)N Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits dopa decarboxylase and depletes animal tissues of norepinephrine. Option B: It inhibits norepinephrine reuptake by stimulating alpha(2)-adrenergic receptors. Option C: It inhibits ergosterol synthesis and increases fungal cellular permeability. Option D: It inhibits the reuptake transporters of noradrenaline, dopamine, and seratonin. " A 3295 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC1=CC2=C(C=C1)N=C(S2)S(=O)(=O)N Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits biosynthesis inhibitory activity. Option B: It exhibits enzyme inhibitory activity. Option C: It exhibits carbonic anhydrase inhibitory activity. Option D: It exhibits dual 5α-reductase inhibitory activity. " C 45375808 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3 Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits DNA-dependent RNA polymerase activity. Option B: It exhibits RNA-dependent RNA polymerase inhibitory activity. Option C: It exhibits inhibitory activity on DNA-dependent RNA polymerase. Option D: It exhibits inhibitory activity on RNA-dependent RNA polymerase (RdRp) enzyme complex. " B 4212 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against topoisomerase II. Option B: It exhibits topoisomerase II inhibitory activity. Option C: It exhibits inhibitory activity against topoisomerase I. Option D: It exhibits inhibitory activity against topoisomerase I and II. " B 73282 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NC(=NC(=N1)OC)NC(=O)NS(=O)(=O)C2=CC=CC=C2OCCCl Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits cellular metabolism inhibitory activity. Option B: It exhibits biosynthesis inhibitory activity. Option C: It exhibits enzyme inhibitory activity. Option D: It exhibits nucleotide synthesis inhibitory activity. " B 71771 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)CC(=O)OCC(=O)O)NC2=C(C=CC=C2Cl)Cl Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity towards cyclooxygenases (COX-1 and COX-2). Option B: It exhibits inhibitory activity against COX-2 and 5-lipooxygenase. Option C: It exhibits inhibitory activity against cyclooxygenase 1 and 2. Option D: It exhibits cyclo-oxygenase inhibitory activity. " D 64715 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@H](C)C(=O)O[C@H]1CCC=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits competitive inhibitory activity on HMG-CoA reductase. Option B: It exhibits HMG-Coenzyme A reductase inhibitory activity. Option C: It exhibits competitive inhibitory activity on tyrosinase in melanocytes. Option D: It exhibits inhibitory activity against HMG-CoA reductase (EC 1.1.1.34/EC 1.1.1.88). " B 5323 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=NC(=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N)OC Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits cellular metabolism inhibitory activity. Option B: It exhibits folic acid synthesis inhibitory activity. Option C: It exhibits biosynthesis inhibitory activity. Option D: It exhibits nucleotide synthesis inhibitory activity. " B 126941 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits nucleotide synthesis inhibitory activity. Option B: It exhibits enzyme inhibitory activity. Option C: It exhibits biosynthesis inhibitory activity. Option D: It exhibits cellular metabolism inhibitory activity. " A 2088 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits nucleotide synthesis inhibitory activity. Option B: It exhibits biosynthesis inhibitory activity. Option C: It exhibits farnesyl pyrophosphate synthetase inhibitory activity. Option D: It exhibits enzyme inhibitory activity. " C 657298 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC1=CC(=O)NC(=S)N1 Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exerts an inhibitory effect on lipid peroxidation. Option B: It is a potent inhibitor of actin polymerisation and DNA synthesis. Option C: It exhibits potent inhibitory activity towards mitochondrial NADH oxidase. Option D: It exhibits thyroid peroxidase inhibitory activity. " D 2431 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[N+](C)(C)CC1=CC=CC=C1Br Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits the synthesis of DNA. Option B: It exhibits Na,K-ATPase inhibitory activity. Option C: It inhibits the Na-K-ATPase membrane pump. Option D: It inhibits the synthesis of DNA and RNA. " B 586 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(CC(=O)O)C(=N)N Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits the enzyme aromatase. Option B: It inhibits the synthesis of DNA. Option C: It inhibits the synthesis of DNA and RNA. Option D: It exhibits reversible catalytic activity. " D 4771 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(CC1=CC=CC=C1)N Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits the reuptake transporters of noradrenaline, dopamine, and seratonin. Option B: It inhibits dopa decarboxylase and depletes animal tissues of norepinephrine. Option C: It inhibits norepinephrine reuptake by stimulating alpha(2)-adrenergic receptors. Option D: It inhibits ergosterol synthesis and increases fungal cellular permeability. " A 6262 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C[C@@H](C(=O)O)N)CN Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits the synthesis of DNA and RNA. Option B: It inhibits the synthesis of DNA. Option C: It inhibits the enzyme aromatase. Option D: It crosses the inner mitochondrial membrane and inhibits carbamylase. " D 5853 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=O)(C(C(Cl)(Cl)Cl)O)OC Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It possesses significant inhibitory activity against acetylcholinesterase enzyme (EC 3.1.1.7). Option B: It exhibits inhibitory activity against acetylcholinesterase. Option C: It inhibits cholinesterase. Option D: Ethion is an organophosphate insecticide with inhibitory activity towards the enzyme acetylcholinesterase (EC 3.1.1.7). " C 4735 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits the synthesis of DNA, RNA, phospholipids, and proteins. Option B: It inhibits the synthesis of DNA. Option C: It inhibits protein, RNA, and DNA synthesis. Option D: It inhibits the synthesis of DNA and RNA. " A 439501 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@H]2C[C@H]([C@@]3([C@@H]4[C@@H](CC[C@@]3(C2)O)[C@]5(CC[C@@H]([C@]5(C[C@H]4O)C)C6=CC(=O)OC6)O)CO)O)O)O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits the synthesis of DNA and RNA. Option B: It exhibits Na,K-ATPase inhibitory activity. Option C: It inhibits the synthesis of DNA. Option D: It inhibits the Na-K-ATPase membrane pump. " D 3357 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CCN(CC1)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)CCF)F Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It possesses significant inhibitory activity against acetylcholinesterase enzyme (EC 3.1.1.7). Option B: It exhibits inhibitory activity against acetylcholinesterase. Option C: It inhibits the DNA-supercoiling activity of DNA gyrase. Option D: It inhibits the hydrolysis of acetylcholine. " C 54892 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2CC3=CC=CC=C3C[C@H]2C(=O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits photosynthesis in susceptible species. Option B: It inhibits AdoMet-mediated processes. Option C: It inhibits ACE. Option D: It inhibits GABA. " C 54680692 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits GABA. Option B: It inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). Option C: It inhibits vitamin K reductase. Option D: It inhibits aberrant cell growth and proliferation by targeting IDH1. " C 70788951 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[PH+](CC)CC.CC(=O)OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)[S-])OC(=O)C)OC(=O)C)OC(=O)C.[Au] Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits ACE. Option B: It inhibits GABA. Option C: It inhibits heme oxygenase 1. Option D: It inhibits heme polymerase activity. " C 5329102 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\\2/C3=C(C=CC(=C3)F)NC2=O)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits cellular signaling by targeting multiple RTKs. Option B: It inhibits aberrant cell growth and proliferation by targeting IDH1. Option C: It inhibits excitatory neurotransmission through actions on kainate and AMPA receptors. Option D: It exhibits inhibitory activity on ADP-mediated platelet activation and aggregation. " A 23978 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Cu] Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits heme oxygenase 1. Option B: It inhibits cytochrome c oxidase. Option C: It reversibly inhibits thrombin. Option D: It inhibits heme polymerase activity. " B 3366 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC(=O)NC(=C1F)N Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits the synthesis of DNA. Option B: It inhibits the enzyme aromatase. Option C: It inhibits the synthesis of DNA and RNA. Option D: It inhibits GABA. " C 33775 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC1=C(C(=O)N(N=C1)C2=CC=CC(=C2)C(F)(F)F)Cl Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits carotenoid synthesis. Option B: It inhibits ACE. Option C: It inhibits photosynthesis in susceptible species. Option D: It inhibits GABA. " A 4679 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C(=NC=C1)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC(F)F)OC Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits potent inhibitory activity towards mitochondrial NADH oxidase. Option B: It inhibits the activity of dimethylarginine dimethylaminohydrolase (DDAH). Option C: It exhibits dimethylarginine dimethylaminohydrolase inhibitory activity. Option D: It exerts an inhibitory effect on lipid peroxidation. " B 124886 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(=O)N[C@@H](CS)C(=O)NCC(=O)O)[C@@H](C(=O)O)N Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It catalyzes the conversion of methylglyoxal and reduced this molecule to S-D-Lactoyl-glutathione. Option B: It inhibits 2-oxoglutarate-dependent histone and DNA demethylase enzymes. Option C: It inhibits the DNA-supercoiling activity of DNA gyrase. Option D: It inhibits the hydrolysis of acetylcholine. " A 657181 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6 Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity on nitric oxide production. Option B: It causes an inhibition of estrogen and androgen production. Option C: It has been shown to exhibit inhibitory activity against nitric oxide production. Option D: It exhibits inhibitory activity against androgen receptor. " B 54738 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C1(C(=O)NC(=N1)C2=C(C=CC=N2)C(=O)O)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits photosynthesis in susceptible species. Option B: It inhibits acetolactate synthase. Option C: It inhibits GABA. Option D: It inhibits the synthesis of DNA. " B 4236 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)S(=O)CC(=O)N Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits photosynthesis in susceptible species. Option B: It inhibits GABA. Option C: It inhibits the synthesis of DNA. Option D: It inhibits the synthesis of DNA and RNA. " B 14969 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@H]([C@@](C[C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)[C@H]([C@H](C(=O)N[C@H](C(=O)N[C@H]5C(=O)N[C@@H]7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)[C@H](NC(=O)[C@H]([C@@H](C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)[C@@H](CC(C)C)NC)O)Cl)CO)O)O)(C)N)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It prevents incorporation of N-acetylmuramic acid (NAM)- and N-acetylglucosamine (NAG)-peptide subunits from being incorporated into the peptidoglycan matrix. Option B: It exhibits inhibitory activity on a process mediated by H2O2 produced in the oxidation of amines. Option C: It inhibits nucleic acid (DNA and RNA) and protein synthesis by forming complexes with DNA and inhibiting topoisomerase II activity. Option D: It inhibits urate crystal deposition, possibly by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. " A 1110 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(=O)O)C(=O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits 2-oxoglutarate-dependent histone and DNA demethylase enzymes. Option B: It inhibits the production of kynurenic acid in brain tissue slices. Option C: It inhibits aberrant cell growth and proliferation by targeting IDH1. Option D: It inhibits the DNA-supercoiling activity of DNA gyrase. " A 4915 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NC(=O)C1=CC=C(C=C1)CNNC Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits the synthesis of DNA. Option B: It inhibits the enzyme aromatase. Option C: It inhibits the synthesis of DNA and RNA. Option D: It inhibits protein, RNA, and DNA synthesis. " D 33741 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C[C@H]1CCCC[C@@]1(C2=CC(=CC=C2)OC)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits the reuptake transporters of noradrenaline, dopamine, and seratonin. Option B: It inhibits ergosterol synthesis and increases fungal cellular permeability. Option C: It inhibits dopa decarboxylase and depletes animal tissues of norepinephrine. Option D: It inhibits norepinephrine reuptake by stimulating alpha(2)-adrenergic receptors. " D 2812 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4 Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It strongly inhibits both calpains I and II. Option B: It inhibits ergosterol synthesis and increases fungal cellular permeability. Option C: It inhibits biosynthesis of the sterol ergostol. Option D: It inhibits dopa decarboxylase and depletes animal tissues of norepinephrine. " C 439155 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CSCC[C@@H](C(=O)O)N)O)O)N Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits the synthesis of DNA. Option B: It inhibits GABA. Option C: It inhibits AdoMet-mediated processes. Option D: It inhibits photosynthesis in susceptible species. " C 43815 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4 Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits ACE. Option B: It inhibits GABA. Option C: It inhibits serotonin reuptake. Option D: It inhibits photosynthesis in susceptible species. " C 3950 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(CC1)NC(=O)N(CCCl)N=O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits protein, RNA, and DNA synthesis. Option B: It inhibits the synthesis of DNA and RNA. Option C: It inhibits the synthesis of DNA. Option D: It inhibits carbamoylation and modification of cellular proteins. " D 5029 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCCCOC Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against chymotrypsin. Option B: It exhibits inhibitory activity against NF-kappaB. Option C: It exhibits inhibitory activity against platelet aggregation. Option D: It exhibits inhibitory activity on the H+, K+ATPase of the coating gastric cells. " D 971 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(=O)O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits competitive inhibitory activity on tyrosinase in melanocytes. Option B: It exhibits inhibitory activity against NF-kappaB. Option C: It exhibits competitive inhibitory activity on lactate dehydrogenase (LDH). Option D: It exhibits competitive inhibitory activity on HMG-CoA reductase. " C 445643 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against platelet aggregation. Option B: It exhibits inhibitory activity on calcineurin. Option C: It exhibits inhibitory activity against NF-kappaB. Option D: It exhibits inhibitory activity against chymotrypsin. " B 6329 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity on muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. Option B: It exhibits inhibitory activity on a process mediated by H2O2 produced in the oxidation of amines. Option C: It exhibits inhibitory activity on ADP-mediated platelet activation and aggregation. Option D: It exhibits inhibitory activity on PAR-1, a thrombin receptor expressed on platelets. " B 53232 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits HMG-Coenzyme A reductase inhibitory activity. Option B: It exhibits competitive inhibitory activity on tyrosinase in melanocytes. Option C: It exhibits competitive inhibitory activity on HMG-CoA reductase. Option D: It exhibits inhibitory activity against HMG-CoA reductase (EC 1.1.1.34/EC 1.1.1.88). " C 39186 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)O[C@@H]1[C@@H](SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits excitatory neurotransmission through actions on kainate and AMPA receptors. Option B: It exhibits inhibitory activity on ADP-mediated platelet activation and aggregation. Option C: It exhibits inhibitory activity on the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. Option D: It exhibits inhibitory activity on muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. " C 440936 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1O)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against chymotrypsin. Option B: It exhibits inhibitory activity against phospholipase A2 and tyrosinase. Option C: It exhibits competitive inhibitory activity on tyrosinase in melanocytes. Option D: It exhibits inhibitory activity against tyrosinase. " C 2784 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+]12CCC(CC1)C(C2)OC(=O)C(C3=CC=CC=C3)(C4=CC=CC=C4)O Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It inhibits excitatory neurotransmission through actions on kainate and AMPA receptors. Option B: It exhibits inhibitory activity on ADP-mediated platelet activation and aggregation. Option C: It exhibits inhibitory activity on muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. Option D: It exhibits inhibitory activity on the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. " C 105089 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC[C@@H](C(=O)O)N Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits inhibitory activity against NF-kappaB. Option B: It exhibits inhibitory activity against platelet aggregation. Option C: It exhibits inhibitory activity on protein association of L-BMAA. Option D: It exhibits inhibitory activity against chymotrypsin. " C 2662 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit? Option A: It exhibits selective inhibitory activity on cycloxgenase-2 (Cox-2). Option B: It exhibits inhibitory activity against COX-2 and 5-lipooxygenase. Option C: It exhibits inhibitory activity towards cyclooxygenases (COX-1 and COX-2). Option D: It exhibits inhibitory activity against cyclooxygenase 1 and 2. " A 7498 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)CBr Question about this molecule: Which kind of irritant is this molecule? Option A: It is a strong irritant to skin, eyes, and mucous membranes. Option B: It is an irritant to the skin, eyes, and mucous membranes. Option C: It is a strong irritant to the skin, eyes, and mucous membranes. Option D: It is a strong lachrymator, intensely irritating to skin and mucous membranes. " D 10967 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(OCCl)Cl Question about this molecule: Which kind of irritant is this molecule? Option A: It may cause skin, mucous membrane, and respiratory tract irritation. Option B: It is irritating to the skin, eyes, and mucous membranes in humans. Option C: It may be irritating to skin, eyes, and mucous membranes. Option D: It may cause irritation to skin, eyes, and mucous membranes. " A 6569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)C Question about this molecule: Which kind of irritant is this molecule? Option A: It results in irritation to the eyes, nose, and throat. Option B: It results in irritation of the eyes, nasal passages, throat, and lungs. Option C: It is extremely irritating to the eyes, nose, and throat. Option D: It may result in irritation and burning of the eyes, nose, throat, and skin. " A 23953 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [SiH4] Question about this molecule: Which kind of irritant is this molecule? Option A: It is an irritant to skin, eyes, and mucous membranes. Option B: It is a strong irritant to the skin, eyes, and mucous membranes. Option C: It is a strong irritant to skin, eyes, and mucous membranes. Option D: It is an irritant to the skin, eyes, and mucous membranes. " C 957 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCO Question about this molecule: Which kind of irritant is this molecule? Option A: It irritates the nose and throat. Option B: It irritates the eyes, nose, and throat. Option C: It irritates the eyes and respiratory system. Option D: It may irritate the eyes, nose, and respiratory system. " D 6954 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1[N+](=O)[O-])O)[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: Which kind of irritant is this molecule? Option A: It may be irritating to skin and mucous membranes. Option B: It is irritating to the skin, eyes, and mucous membranes in humans. Option C: It may be irritating to skin, eyes, and mucous membranes. Option D: It may cause irritation to skin, eyes, and mucous membranes. " A 7903 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC[N+](=O)[O-] Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate skin, eyes, and mucous membranes. Option B: It may irritate the skin, eyes, and mucous membranes. Option C: It can irritate skin, eyes, and mucous membranes. Option D: It may irritate skin, eyes and mucous membranes. " A 10129889 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Li+].[N+](=O)([O-])[O-] Question about this molecule: Which kind of irritant is this molecule? Option A: It is irritating to the skin, eyes, and mucous membranes in humans. Option B: It may be irritating to skin, eyes, and mucous membranes. Option C: It is very irritating to skin, eyes, and mucous membranes. Option D: It may cause irritation to skin, eyes, and mucous membranes. " D 7845 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC=C Question about this molecule: Which kind of irritant is this molecule? Option A: It may result in irritation and burning of the eyes, nose, throat, and skin. Option B: It causes irritation to the eyes, respiratory tract, and skin. Option C: It results in irritation of the eyes, nasal passages, throat, and lungs. Option D: It is irritating to the eyes, skin, and respiratory tract in humans. " C 6419 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)(Cl)Cl)(Cl)Cl Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate eyes and skin. Option B: It irritates skin and eyes. Option C: It may irritate skin and eyes. Option D: Contact with it irritates skin and eyes. " C 656671 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]S(=O)S(=O)(=O)[O-].[Na+].[Na+] Question about this molecule: Which kind of irritant is this molecule? Option A: It may severely irritate skin and eyes. Option B: It may mildly irritate skin and eyes. Option C: It strongly irritates skin and tissue. Option D: It severely irritates skin and eyes. " C 13838 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[Si](C)(C)N[Si](C)(C)C Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate eyes and skin. Option B: Contact with it irritates skin and eyes. Option C: It irritates skin and eyes. Option D: It may irritate skin and eyes. " C 9550 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=[N+]=[N-] Question about this molecule: Which kind of irritant is this molecule? Option A: It is a severe eye irritant. Option B: It is a skin and eye irritant. Option C: It is a strong respiratory irritant. Option D: It is reported to be a mild skin or eye irritant. " C 6658 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=C)C(=O)OC Question about this molecule: Which kind of irritant is this molecule? Option A: It is irritating to the skin, eyes, and mucous membranes in humans. Option B: It may be irritating to skin, eyes, and mucous membranes. Option C: It is very irritating to skin, eyes, and mucous membranes. Option D: It may cause irritation to skin, eyes, and mucous membranes. " A 24934 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-][Se](=O)[O-].[Na+].[Na+] Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate the skin, eyes, and mucous membranes. Option B: It may irritate skin, eyes and mucous membranes. Option C: It can irritate skin, eyes, and mucous membranes. Option D: It may irritate skin, eyes, and mucous membranes. " D 176879 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)OC(=O)NNC1=C(C=CC(=C1)C2=CC=CC=C2)OC Question about this molecule: Which kind of irritant is this molecule? Option A: It is a strong irritant to skin and eyes. Option B: It is a mild irritant to skin and eyes. Option C: It is a strong irritant to skin, eyes, and mucous membranes. Option D: It is non-irritating to skin and minimally irritating to eyes. " D 8060 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCN Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate the eyes, nose, and respiratory system. Option B: It irritates the eyes and respiratory system. Option C: It irritates the nose and throat. Option D: It irritates the eyes, nose, and throat. " B 7945 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)CC(C)C Question about this molecule: Which kind of irritant is this molecule? Option A: It may severely irritate skin and eyes. Option B: It may irritate skin and eyes. Option C: It may irritate eyes and skin. Option D: It may mildly irritate skin and eyes. " D 7367 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(Cl)(Cl)Cl Question about this molecule: Which kind of irritant is this molecule? Option A: It is a strong irritant to the skin, eyes, and mucous membranes. Option B: Acute (short-term) exposure to the vapors of it is highly irritating to the skin and mucous membranes. Option C: It is highly corrosive and irritating to the skin, eyes, and mucous membranes. Option D: It is highly irritating to the skin, eyes, and mucous membranes in humans after acute inhalation or dermal exposures. " B 7672 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)N=C=O Question about this molecule: Which kind of irritant is this molecule? Option A: It is irritating to the skin, eyes, and mucous membranes in humans. Option B: It is very irritating to skin, eyes, and mucous membranes. Option C: It may be irritating to skin, eyes, and mucous membranes. Option D: It may cause irritation to skin, eyes, and mucous membranes. " B 6579 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC(=O)N Question about this molecule: Which kind of irritant is this molecule? Option A: It is irritating to the skin and eyes. Option B: It is mildly irritating to both the eyes and skin. Option C: It is irritating to skin and eyes. Option D: It is toxic and irritating to skin, eyes, etc. " D 6568 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C)O Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate the eyes and skin in humans. Option B: It may irritate eyes and skin. Option C: It can irritate the skin and eyes in humans. Option D: It moderately irritates the eyes and skin. " D 7923 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=O)OC1=O Question about this molecule: Which kind of irritant is this molecule? Option A: It may slightly irritate skin, eyes, and mucous membranes. Option B: It may severely irritate skin, eyes, and mucous membranes. Option C: It strongly irritates skin, eyes, and mucous membranes. Option D: Vapors, fumes, and dusts strongly irritate the eyes, skin, and mucous membranes. " D 9321 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: NN Question about this molecule: Which kind of irritant is this molecule? Option A: Contact with it irritates skin and eyes. Option B: It irritates skin and eyes. Option C: It may irritate skin and eyes. Option D: It irritates skin and eyes; irritation to the eyes is delayed. " D 7720 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(CC)CO Question about this molecule: Which kind of irritant is this molecule? Option A: It can irritate skin, eyes, and mucous membranes. Option B: It may irritate skin, eyes and mucous membranes. Option C: It may irritate the skin, eyes, and mucous membranes. Option D: It may irritate skin, eyes, and mucous membranes. " D 7342 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C(C)C Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate eyes and skin. Option B: It may irritate skin and eyes. Option C: It irritates skin and eyes. Option D: Contact with it irritates skin and eyes. " B 7501 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC1=CC=CC=C1 Question about this molecule: Which kind of irritant is this molecule? Option A: It is irritating to the eyes and mucous membranes. Option B: It is initially irritating to the eyes and mucous membranes. Option C: It may be irritating to skin and mucous membranes. Option D: It is very irritating to skin and mucous membranes. " A 11167 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN=C=S Question about this molecule: Which kind of irritant is this molecule? Option A: It may result in irritation and burning of the eyes, nose, throat, and skin. Option B: It results in irritation to the eyes, nose, and throat. Option C: It results in irritation of the eyes, nasal passages, throat, and lungs. Option D: It may cause tearing and irritate the eyes, skin, nose, and throat. " D 6228 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C=O Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate skin and eyes. Option B: It irritates skin and eyes. Option C: It may irritate eyes. Option D: It may irritate eyes and skin. " C 5054 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC(=C1)O)O Question about this molecule: Which kind of irritant is this molecule? Option A: It is extremely irritating, especially to the eyes. Option B: It is irritating to the eyes. Option C: It is irritating to skin and eyes. Option D: It is irritating to the skin and eyes. " C 12388 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCC Question about this molecule: Which kind of irritant is this molecule? Option A: It may severely irritate skin, eyes, lungs, or mucous membranes. Option B: It may severely irritate skin, eyes, and mucous membranes. Option C: Inhalation exposure may result in irritation of the nose and throat, and dermal exposure may irritate the skin. Option D: Repeated or prolonged skin contact may irritate or redden skin, progressing to dermatitis. " D 6407 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)C(Cl)(Cl)Cl Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate the skin, eyes, and mucous membranes. Option B: It may irritate skin, eyes and mucous membranes. Option C: It can irritate skin, eyes, and mucous membranes. Option D: It may irritate skin, eyes, and mucous membranes. " B 12986 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(=C)C Question about this molecule: Which kind of irritant is this molecule? Option A: It is a strong irritant to skin and eyes. Option B: It is an irritating vapor. Option C: It produces a flammable, irritating vapor. Option D: It is a mild irritant to skin and eyes. " B 7514 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC1CCCCC1 Question about this molecule: Which kind of irritant is this molecule? Option A: It is a strong irritant to skin, eyes, and mucous membranes. Option B: It is a strong irritant to the skin, eyes, and mucous membranes. Option C: It is a mild irritant to skin and eyes. Option D: It is a strong irritant to skin and eyes. " D 946 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: N(=O)[O-] Question about this molecule: Which kind of irritant is this molecule? Option A: It may cause irritation to skin, eyes, and mucous membranes. Option B: It is very irritating to skin, eyes, and mucous membranes. Option C: It is irritating to the skin, eyes, and mucous membranes in humans. Option D: It may be irritating to skin, eyes, and mucous membranes. " A 7955 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=NC(=NC(=N1)N)N)N Question about this molecule: Which kind of irritant is this molecule? Option A: It is a mild irritant to skin and eyes. Option B: It is a skin and eye irritant. Option C: It is reported to be a mild skin or eye irritant. Option D: It is an eye, skin and respiratory irritant. " D 5976 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)N Question about this molecule: Which kind of irritant is this molecule? Option A: It is a strong irritant to skin, eyes, and mucous membranes. Option B: It is a strong irritant to the skin, eyes, and mucous membranes. Option C: It is highly corrosive and irritating to the skin, eyes, and mucous membranes. Option D: It is an irritant to the skin, eyes, and mucous membranes. " C 10541 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=O)(OC)OC Question about this molecule: Which kind of irritant is this molecule? Option A: It can irritate the skin and eyes in humans. Option B: Inhalation may irritate the respiratory tract. Option C: It may severely irritate the eyes and respiratory tract. Option D: It may irritate the eyes and skin in humans. " B 7690 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC=C(C=C1)CC(=O)O Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate skin and eyes. Option B: It severely irritates skin and eyes. Option C: It may severely irritate skin and eyes. Option D: It may mildly irritate skin and eyes. " B 1480 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=CC(=C1Cl)Cl)Cl)OCC(=O)O Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate eyes and skin. Option B: It may irritate skin and eyes. Option C: It may irritate the skin. Option D: It can irritate the skin and eyes in humans. " C 3598 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate the skin, eyes, and mucous membranes. Option B: It may irritate skin, eyes, and mucous membranes. Option C: It can irritate skin, eyes, and mucous membranes. Option D: It may irritate skin, eyes and mucous membranes. " D 10607 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC(=CC(=C1OC)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@H](C4=CC5=C(C=C24)OCO5)O Question about this molecule: Which kind of irritant is this molecule? Option A: It is very irritating to skin, eyes, and mucous membranes. Option B: It may be irritating to skin, eyes, and mucous membranes. Option C: It is very irritating to skin and mucous membranes. Option D: It may be irritating to skin and mucous membranes. " C 31373 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=C(Cl)Cl)(Cl)Cl Question about this molecule: Which kind of irritant is this molecule? Option A: It causes mild skin irritation. Option B: It can cause slight irritation to the eye and skin. Option C: It causes severe eye irritation and moderate skin irritation. Option D: It potentially results in skin irritation. " D 8109 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOCCCO Question about this molecule: Which kind of irritant is this molecule? Option A: It may slightly irritate skin, eyes and mucous membranes. Option B: It may severely irritate skin, eyes, and mucous membranes. Option C: It may severely irritate skin, eyes, lungs, or mucous membranes. Option D: It may slightly irritate skin, eyes, and mucous membranes. " A 10039 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)=S Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate eyes and skin. Option B: It may irritate the eyes and skin in humans. Option C: It can irritate the skin and eyes in humans. Option D: It may irritate skin and eyes. " B 1119 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=S=O Question about this molecule: Which kind of irritant is this molecule? Option A: Its vapors can irritate the eyes and mucous membranes. Option B: It may irritate the skin, eyes, and mucous membranes. Option C: It may irritate skin, eyes and mucous membranes. Option D: It may irritate the eyes and mucous membranes. " D 7409 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C1=CC=CC=C1)O Question about this molecule: Which kind of irritant is this molecule? Option A: It may slightly irritate skin, eyes and mucous membranes. Option B: It may severely irritate skin, eyes, and mucous membranes. Option C: It may severely irritate skin, eyes, lungs, or mucous membranes. Option D: It may slightly irritate skin, eyes, and mucous membranes. " A 8113 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CO)NCCO Question about this molecule: Which kind of irritant is this molecule? Option A: It may severely irritate skin, eyes, and mucous membranes. Option B: It is highly irritating to the skin, eyes, and mucous membranes in humans after acute inhalation or dermal exposures. Option C: It may severely irritate skin, eyes, lungs, or mucous membranes. Option D: Inhalation exposure may result in irritation of the nose and throat, and dermal exposure may irritate the skin. " D 105034 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=[N-])=O Question about this molecule: Which kind of irritant is this molecule? Option A: It can irritate skin, eyes, and mucous membranes. Option B: It irritates the skin, eyes, and mucous membranes. Option C: It irritates skin, eyes, and mucous membranes. Option D: It may irritate skin, eyes, and mucous membranes. " C 980 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1[N+](=O)[O-])O Question about this molecule: Which kind of irritant is this molecule? Option A: It is extremely irritating to the eyes, nose, and throat. Option B: Contact with eyes causes irritation in humans. Option C: It results in irritation to the eyes, nose, and throat. Option D: It may result in irritation and burning of the eyes, nose, throat, and skin. " B 22386 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(C)O Question about this molecule: Which kind of irritant is this molecule? Option A: It may slightly irritate skin, eyes, and mucous membranes. Option B: It may severely irritate skin, eyes, lungs, or mucous membranes. Option C: It is a moderately toxic irritant by ingestion and vapors may irritate skin and eyes. Option D: It may severely irritate skin, eyes, and mucous membranes. " C 24570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: Cl[As](Cl)Cl Question about this molecule: Which kind of irritant is this molecule? Option A: It is a strong irritant to skin, eyes, and mucous membranes. Option B: It is an irritant to the skin, eyes, and mucous membranes. Option C: It is a strong irritant to the skin, eyes, and mucous membranes. Option D: It is an irritant to skin, eyes, and mucous membranes. " B 8370 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=C(C(=C(C(=C1Cl)Cl)Cl)Cl)Cl)Cl Question about this molecule: Which kind of irritant is this molecule? Option A: It can irritate skin, eyes, and mucous membranes upon contact. Option B: It may irritate skin, eyes and mucous membranes. Option C: It may irritate skin, eyes, and mucous membranes. Option D: It can irritate skin, eyes, and mucous membranes. " A 30318 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=[Os](=O)(=O)=O Question about this molecule: Which kind of irritant is this molecule? Option A: It is a strong irritant to the eyes and mucous membranes and is toxic by inhalation. Option B: It is an irritant to the skin, eyes, and mucous membranes. Option C: It is a strong irritant to skin, eyes, and mucous membranes. Option D: It is a strong irritant to the skin, eyes, and mucous membranes. " A 2730 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OC1=NC(=C(C=C1Cl)Cl)Cl Question about this molecule: Which kind of irritant is this molecule? Option A: It causes irritation to the eyes, respiratory tract, and skin. Option B: It is irritating to the eyes, skin, and respiratory tract in humans. Option C: It is irritating to the skin, eyes, and mucous membranes in humans. Option D: It can cause slight irritation to the eye and skin. " D 1031 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCO Question about this molecule: Which kind of irritant is this molecule? Option A: It mildly irritates the eyes, nose, and throat and its vapors are heavier than air. Option B: It results in irritation of the eyes, nasal passages, throat, and lungs. Option C: It may result in irritation and burning of the eyes, nose, throat, and skin. Option D: It may cause tearing and irritate the eyes, skin, nose, and throat. " A 24385 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: Cl[Ni]Cl Question about this molecule: Which kind of irritant is this molecule? Option A: It can irritate skin, eyes, and mucous membranes. Option B: It may irritate skin, eyes and mucous membranes. Option C: It may irritate skin, eyes, and mucous membranes. Option D: It can irritate skin, eyes, and mucous membranes upon contact. " D 244 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)CO Question about this molecule: Which kind of irritant is this molecule? Option A: It can irritate skin, eyes, and mucous membranes. Option B: It may irritate skin, eyes and mucous membranes. Option C: It can irritate skin, eyes, and mucous membranes upon contact. Option D: It may irritate skin, eyes, and mucous membranes. " C 4499 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC Question about this molecule: Which kind of irritant is this molecule? Option A: It prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction by inhibiting the influx of calcium in smooth muscle cells. Option B: Inhalation exposure may result in irritation of the nose and throat, and dermal exposure may irritate the skin. Option C: It causes irritation of the upper respiratory tract and eyes, sore throat, dizziness, and headache. Option D: It is toxic, causing severe eye, nose, throat and lung irritation, along with headaches, drowsiness and dizziness. " A 7954 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=NC(=NC(=N1)Cl)Cl)Cl Question about this molecule: Which kind of irritant is this molecule? Option A: It irritates skin and eyes. Option B: It may irritate eyes and skin. Option C: Contact with it irritates skin and eyes. Option D: It may irritate skin and eyes. " A 7635 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(CC)COC(=O)C Question about this molecule: Which kind of irritant is this molecule? Option A: Its vapors can irritate skin and eyes. Option B: Its liquid or vapors may irritate skin and eyes. Option C: It may irritate eyes and skin. Option D: It may irritate skin and eyes. " B 6544 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=O)CC(C1)(C)C Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate eyes and skin. Option B: Contact with it irritates skin and eyes. Option C: It may irritate skin and eyes. Option D: It irritates skin and eyes. " B 7361 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=COC(=C1)CO Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate skin, eyes and mucous membranes. Option B: It can irritate skin, eyes, and mucous membranes upon contact. Option C: It can irritate skin, eyes, and mucous membranes. Option D: It may irritate skin, eyes, and mucous membranes. " B 62329 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=C(C(=C1[N+](=O)[O-])C(C)(C)C)[N+](=O)[O-])C)[N+](=O)[O-] Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate skin, eyes and mucous membranes. Option B: It may irritate skin, eyes, and mucous membranes. Option C: It can irritate skin, eyes, and mucous membranes upon contact. Option D: It can irritate skin, eyes, and mucous membranes. " C 9864 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(#N)N Question about this molecule: Which kind of irritant is this molecule? Option A: It is irritating to the eyes, skin, and respiratory tract in humans. Option B: It is irritating to the skin, eyes, and mucous membranes in humans. Option C: It may be irritating to skin, eyes, and mucous membranes. Option D: It causes irritation to the eyes, respiratory tract, and skin. " A 8607 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=O)N(C2=O)SC(Cl)(Cl)Cl Question about this molecule: Which kind of irritant is this molecule? Option A: It may be irritating to skin, eyes, and mucous membranes. Option B: It is irritating to the skin, eyes, and mucous membranes in humans. Option C: It is very irritating to skin, eyes, and mucous membranes. Option D: It is very irritating to the eyes and repeated or prolonged contact leads to skin sensitization. " D 6354 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CO1 Question about this molecule: Which kind of irritant is this molecule? Option A: It irritates the eyes and respiratory system. Option B: Its vapors irritate the eyes, skin, and respiratory system. Option C: It irritates the eyes, nose, and throat. Option D: It may irritate the eyes, nose, and respiratory system. " B 7047 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC=N2 Question about this molecule: Which kind of irritant is this molecule? Option A: It can irritate skin, eyes, and mucous membranes upon contact. Option B: It can irritate skin, eyes, and mucous membranes. Option C: It may irritate skin, eyes, and mucous membranes. Option D: It may irritate skin, eyes and mucous membranes. " A 31276 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CCOC(=O)C Question about this molecule: Which kind of irritant is this molecule? Option A: It is a mild irritant to skin and eyes. Option B: It is a strong irritant to skin and eyes. Option C: It is an irritating vapor. Option D: It produces a flammable, irritating vapor. " D 7847 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC=O Question about this molecule: Which kind of irritant is this molecule? Option A: It is very irritating to skin and mucous membranes. Option B: It may be irritating to skin and mucous membranes. Option C: It is initially irritating to the eyes and mucous membranes. Option D: It is irritating to the eyes and mucous membranes. " C 8404 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC2=CC=CC=C2C1 Question about this molecule: Which kind of irritant is this molecule? Option A: It is very irritating to skin, eyes, and mucous membranes. Option B: It is irritating to the skin, eyes, and mucous membranes in humans. Option C: It may be irritating to skin, eyes, and mucous membranes. Option D: It may cause irritation to skin, eyes, and mucous membranes. " C 13387 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CCCC1=O Question about this molecule: Which kind of irritant is this molecule? Option A: It can irritate skin, eyes, and mucous membranes. Option B: It may irritate skin, eyes, and mucous membranes. Option C: It may irritate skin, eyes and mucous membranes. Option D: It can irritate skin, eyes, and mucous membranes upon contact. " D 7570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CC2=CC=C(C=C2)N=C=O)N=C=O Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate eyes and skin. Option B: It can irritate the skin and eyes of rabbits. Option C: It may irritate the eyes and skin in humans. Option D: It can irritate the skin and eyes in humans. " B 11715 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)CBr Question about this molecule: Which kind of irritant is this molecule? Option A: It is a strong irritant to skin, eyes, and mucous membranes. Option B: It is a violent lachrymator and can be very irritating to the eyes. Option C: It is a strong lachrymator, intensely irritating to skin and mucous membranes. Option D: It is a strong irritant to the skin, eyes, and mucous membranes. " B 7775 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC(=O)OCC(C)C Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate skin, eyes and mucous membranes. Option B: It can irritate skin, eyes, and mucous membranes upon contact. Option C: It can irritate skin, eyes, and mucous membranes. Option D: It may irritate skin, eyes, and mucous membranes. " B 712 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=O Question about this molecule: Which kind of irritant is this molecule? Option A: It can irritate the eyes and mucous membranes, causing watery eyes, headache, a burning sensation in the throat, and difficulty breathing at concentrations above 0.1 mg/kg in air. Option B: It is toxic, causing severe eye, nose, throat and lung irritation, along with headaches, drowsiness and dizziness. Option C: Inhalation exposure may result in irritation of the nose and throat, and dermal exposure may irritate the skin. Option D: It causes irritation of the upper respiratory tract and eyes, sore throat, dizziness, and headache. " A 7577 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CC2=CC=C(C=C2)N)N Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate eyes and skin. Option B: It may irritate the eyes and skin in humans. Option C: It may irritate skin and eyes. Option D: It can irritate the skin and eyes in humans. " D 784 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OO Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate skin, eyes and mucous membranes. Option B: Its vapors can irritate the eyes and mucous membranes. Option C: It may irritate the skin, eyes, and mucous membranes. Option D: It may irritate the eyes and mucous membranes. " B 14778 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=[Ca] Question about this molecule: Which kind of irritant is this molecule? Option A: It is an irritant to the skin, eyes, and mucous membranes. Option B: It is an irritant to skin, eyes, and mucous membranes. Option C: It is a strong irritant to skin, eyes, and mucous membranes. Option D: It is a strong irritant to the skin, eyes, and mucous membranes. " C 6276 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCO Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate eyes and skin. Option B: Its vapors can irritate skin and eyes. Option C: It may irritate skin and eyes. Option D: It irritates skin and eyes. " B 7965 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(CC1)N Question about this molecule: Which kind of irritant is this molecule? Option A: It irritates the eyes and respiratory system. Option B: It irritates the eyes, nose, and throat. Option C: It may irritate the eyes, nose, and respiratory system. Option D: It irritates the nose and throat. " A 177 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC=O Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate the eyes and mucous membranes. Option B: Its vapors are heavier than air and can irritate the mucous membranes, especially the eyes. Option C: Its vapors can irritate the eyes and mucous membranes. Option D: It may irritate the skin, eyes, and mucous membranes. " B 31374 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)N(C)C Question about this molecule: Which kind of irritant is this molecule? Option A: Contact with it irritates skin and eyes. Option B: It may irritate eyes and skin. Option C: It irritates skin and eyes. Option D: It may irritate skin and eyes. " B 8030 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CSC=C1 Question about this molecule: Which kind of irritant is this molecule? Option A: It irritates the skin, eyes, and mucous membranes. Option B: It irritates skin, eyes, and mucous membranes. Option C: It may irritate skin, eyes, and mucous membranes. Option D: It can irritate skin, eyes, and mucous membranes. " A 61948 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(CBr)(C#N)Br)C#N Question about this molecule: Which kind of irritant is this molecule? Option A: Inhalation exposure may result in irritation of the nose and throat, and dermal exposure may irritate the skin. Option B: It is highly irritating to the skin, eyes, and mucous membranes in humans after acute inhalation or dermal exposures. Option C: It is a known allergen and dermatological irritant that has been banned in many EU countries due to increasing rates of contact allergy. Option D: It may severely irritate skin, eyes, lungs, or mucous membranes. " C 6811 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=O)OC2=O Question about this molecule: Which kind of irritant is this molecule? Option A: It is irritating to the skin, eyes, and mucous membranes in humans. Option B: It is moderately irritating to the skin, mucous membranes, and liver in humans. Option C: It is highly corrosive and irritating to the skin, eyes, and mucous membranes. Option D: It is moderately toxic by inhalation or ingestion and is a skin irritant. " D 10484 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)S Question about this molecule: Which kind of irritant is this molecule? Option A: It is irritating to the eyes. Option B: It is extremely irritating, especially to the eyes. Option C: It is irritating to skin and eyes. Option D: It is irritating to the skin and eyes. " C 7485 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate the skin, eyes, and mucous membranes. Option B: It can irritate skin, eyes, and mucous membranes. Option C: It may irritate skin, eyes and mucous membranes. Option D: It may irritate skin, eyes, and mucous membranes. " B 8071 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCOC Question about this molecule: Which kind of irritant is this molecule? Option A: It severely irritates skin and eyes. Option B: It may severely irritate skin and eyes. Option C: It may mildly irritate skin and eyes. Option D: It may irritate skin and eyes. " A 996 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)O Question about this molecule: Which kind of irritant is this molecule? Option A: It may severely irritate skin, eyes, lungs, or mucous membranes. Option B: It may slightly irritate skin, eyes, and mucous membranes. Option C: It may severely irritate skin, eyes, and mucous membranes. Option D: It is highly irritating to the skin, eyes, and mucous membranes in humans after acute inhalation or dermal exposures. " D 7150 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)C1=CC=CC=C1 Question about this molecule: Which kind of irritant is this molecule? Option A: It may slightly irritate skin, eyes and mucous membranes. Option B: It may severely irritate skin, eyes, and mucous membranes. Option C: It may severely irritate skin, eyes, lungs, or mucous membranes. Option D: It may slightly irritate skin, eyes, and mucous membranes. " D 7410 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C1=CC=CC=C1 Question about this molecule: Which kind of irritant is this molecule? Option A: It is a mild irritant to skin and eyes. Option B: It is a strong irritant to skin, eyes, and mucous membranes. Option C: It is a strong irritant to the skin, eyes, and mucous membranes. Option D: It is a strong irritant to skin and eyes. " A 3310889 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1NN)[N+](=O)[O-] Question about this molecule: Which kind of irritant is this molecule? Option A: It may be irritating to skin, eyes, and mucous membranes. Option B: It is very irritating to skin, eyes, and mucous membranes. Option C: It may cause irritation to skin, eyes, and mucous membranes. Option D: It is irritating to the skin, eyes, and mucous membranes in humans. " A 8082 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCNCC1 Question about this molecule: Which kind of irritant is this molecule? Option A: It may severely irritate skin and eyes. Option B: It may irritate eyes and skin. Option C: It may mildly irritate skin and eyes. Option D: It may irritate skin and eyes. " A 522689 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [F-].[K+] Question about this molecule: Which kind of irritant is this molecule? Option A: It may slightly irritate skin, eyes, and mucous membranes. Option B: It slightly irritates skin, eyes, and mucous membranes. Option C: It strongly irritates skin, eyes, and mucous membranes. Option D: It may slightly irritate skin, eyes and mucous membranes. " C 8184 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCO Question about this molecule: Which kind of irritant is this molecule? Option A: It is mildly irritating to both the eyes and skin. Option B: It is irritating to skin and eyes. Option C: It is irritating to the eyes, skin, and respiratory tract in humans. Option D: It is irritating to the skin and eyes. " A 8133 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOCCO Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate skin and eyes. Option B: Contact with it irritates skin and eyes. Option C: It may irritate eyes and skin. Option D: It irritates skin and eyes. " D 7261 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)N)N Question about this molecule: Which kind of irritant is this molecule? Option A: It irritates skin and eyes. Option B: It may irritate skin and eyes. Option C: Contact with it irritates skin and eyes. Option D: It may irritate eyes and skin. " A 180 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C Question about this molecule: Which kind of irritant is this molecule? Option A: It is a strong irritant to skin, eyes, and mucous membranes. Option B: It is a strong irritant to the eyes and mucous membranes and is toxic by inhalation. Option C: It is a strong irritant to the skin, eyes, and mucous membranes. Option D: It is an irritant and inhalation may lead to hepatotoxic effects. " D 8141 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCC Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate eyes and possibly injure the cornea. Option B: It may irritate the eyes and skin in humans. Option C: It may irritate eyes and skin. Option D: It may irritate skin and eyes. " A 1140 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1 Question about this molecule: Which kind of irritant is this molecule? Option A: It is toxic, causing severe eye, nose, throat and lung irritation, along with headaches, drowsiness and dizziness. Option B: Inhalation exposure may result in irritation of the nose and throat, and dermal exposure may irritate the skin. Option C: It causes irritation of the upper respiratory tract and eyes, sore throat, dizziness, and headache. Option D: It is highly irritating to the skin, eyes, and mucous membranes in humans after acute inhalation or dermal exposures. " C 992 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=C(C(=C(C(=C1Cl)Cl)Cl)Cl)Cl)O Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate eyes and skin. Option B: It may irritate the eyes and skin in humans. Option C: It can irritate the skin, eyes, and mouth. Option D: It can irritate the skin and eyes in humans. " C 31285 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCC=C Question about this molecule: Which kind of irritant is this molecule? Option A: It is an irritating vapor. Option B: It produces a flammable, irritating vapor. Option C: It is a mild irritant to skin and eyes. Option D: It is a strong irritant to skin and eyes. " B 6567 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CN)N Question about this molecule: Which kind of irritant is this molecule? Option A: It severely irritates skin and eyes. Option B: It may mildly irritate skin and eyes. Option C: It strongly irritates skin and tissue. Option D: It may severely irritate skin and eyes. " C 8892 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC(=O)O Question about this molecule: Which kind of irritant is this molecule? Option A: It may severely irritate skin, eyes, lungs, or mucous membranes. Option B: It may slightly irritate skin, eyes and mucous membranes. Option C: It may severely irritate skin, eyes, and mucous membranes. Option D: It may slightly irritate skin, eyes, and mucous membranes. " C 44073 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1C(F)(F)F)Cl)OC2=CC(=C(C=C2)[N+](=O)[O-])C(=O)O Question about this molecule: Which kind of irritant is this molecule? Option A: It can cause slight irritation to the eye and skin. Option B: It causes severe eye irritation and moderate skin irritation. Option C: It potentially results in skin irritation. Option D: It causes mild skin irritation. " B 6214 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)(Cl)Cl)(Cl)(Cl)Cl Question about this molecule: Which kind of irritant is this molecule? Option A: It is very irritating to skin, eyes, and mucous membranes. Option B: It may be irritating to skin, eyes, and mucous membranes. Option C: It is moderately irritating to the skin, mucous membranes, and liver in humans. Option D: It is irritating to the skin, eyes, and mucous membranes in humans. " C 24502 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-][Cr](=O)(=O)O[Cr](=O)(=O)[O-].[K+].[K+] Question about this molecule: Which kind of irritant is this molecule? Option A: It may severely irritate the eyes and respiratory tract. Option B: It severely irritates skin and eyes. Option C: It may mildly irritate skin and eyes. Option D: It may severely irritate skin and eyes. " A 6781 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C1=CC=CC=C1C(=O)OCC Question about this molecule: Which kind of irritant is this molecule? Option A: It may severely irritate skin and eyes. Option B: It severely irritates skin and eyes. Option C: It severely irritates the eyes and mildly irritates the skin. Option D: It may mildly irritate skin and eyes. " C 7515 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC1=CC=CC=C1 Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate the skin, eyes, and mucous membranes. Option B: It may irritate skin, eyes, and mucous membranes. Option C: It can irritate skin, eyes, and mucous membranes. Option D: It may irritate skin, eyes and mucous membranes. " A 5987 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: NS(=O)(=O)O Question about this molecule: Which kind of irritant is this molecule? Option A: It can irritate skin, eyes, and mucous membranes. Option B: It irritates skin, eyes, and mucous membranes. Option C: It irritates the skin, eyes, and mucous membranes. Option D: It may irritate skin, eyes, and mucous membranes. " C 23670523 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1N)[As](=O)(O)[O-].[Na+] Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate skin, eyes, and mucous membranes. Option B: It may irritate the skin, eyes, and mucous membranes. Option C: It may irritate skin, eyes and mucous membranes. Option D: It can irritate skin, eyes, and mucous membranes. " B 6423 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([N+](=O)[O-])(Cl)(Cl)Cl Question about this molecule: Which kind of irritant is this molecule? Option A: It irritates the eyes, nose, and throat. Option B: It irritates the eyes and respiratory system. Option C: It may irritate the eyes, nose, and respiratory system. Option D: It irritates the nose and throat. " A 2513 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[As](=O)(C)O Question about this molecule: Which kind of irritant is this molecule? Option A: It is irritating to skin and eyes. Option B: It is extremely irritating, especially to the eyes. Option C: It is irritating to the eyes. Option D: It is irritating to the skin and eyes. " D 7888 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CCCC(C)(C)O)CC=O Question about this molecule: Which kind of irritant is this molecule? Option A: It is a mild irritant to skin and eyes. Option B: It is a dermatologic irritant and allergen. Option C: It is a skin and eye irritant. Option D: It is reported to be a mild skin or eye irritant. " B 152119 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OP(=S)(O)S Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate skin, eyes and mucous membranes. Option B: It may irritate the skin, eyes, and mucous membranes. Option C: It may irritate skin, eyes, and mucous membranes. Option D: It can irritate skin, eyes, and mucous membranes. " B 176 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)O Question about this molecule: Which kind of irritant is this molecule? Option A: It is a skin and eye irritant. Option B: It was formerly used as a counterirritant and vesicant. Option C: It is a severe eye irritant. Option D: It is used as a counterirritant. " D 6342 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC#N Question about this molecule: Which kind of irritant is this molecule? Option A: It is irritating to the eyes and mucous membranes. Option B: It results in irritation of mucous membranes. Option C: It may be irritating to skin and mucous membranes. Option D: It is initially irritating to the eyes and mucous membranes. " B 13192 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCCN=C=O)CCN=C=O Question about this molecule: Which kind of irritant is this molecule? Option A: It may result in irritation and burning of the eyes, nose, throat, and skin. Option B: It results in irritation of the eyes, nasal passages, throat, and lungs. Option C: It results in irritation to the eyes, nose, and throat. Option D: It is extremely irritating to the eyes, nose, and throat. " D 174 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CO)O Question about this molecule: Which kind of irritant is this molecule? Option A: It is irritating to the eyes, skin, and respiratory tract in humans. Option B: It causes irritation to the eyes, respiratory tract, and skin. Option C: It causes throat and upper respiratory tract irritation. Option D: It may cause skin, mucous membrane, and respiratory tract irritation. " C 6593 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)Cl)(Cl)Cl Question about this molecule: Which kind of irritant is this molecule? Option A: It may be irritating to skin and mucous membranes. Option B: It is very irritating to skin and mucous membranes. Option C: It is initially irritating to the eyes and mucous membranes. Option D: It is irritating to the eyes and mucous membranes. " D 5206 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(OC(C(F)(F)F)C(F)(F)F)F Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate the eyes and skin in humans. Option B: It can irritate the skin and eyes in humans. Option C: It may irritate the skin. Option D: It does not irritate the airway. " D 2345 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)COC(=O)C2=CC=CC=C2 Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate eyes and skin. Option B: It may irritate skin and eyes. Option C: It may irritate eyes. Option D: It has irritant properties. " D 342 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC=C1)O Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate the eyes, nose, and respiratory system. Option B: It irritates the eyes, nose, and throat. Option C: It irritates the nose and throat. Option D: It irritates the eyes and respiratory system. " C 178 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)N Question about this molecule: Which kind of irritant is this molecule? Option A: It causes mild skin irritation. Option B: It potentially results in skin irritation. Option C: It can cause slight irritation to the eye and skin. Option D: It causes severe eye irritation and moderate skin irritation. " A 3893 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCC(=O)O Question about this molecule: Which kind of irritant is this molecule? Option A: It is slightly irritating to mucous membranes. Option B: It is initially irritating to the eyes and mucous membranes. Option C: It is very irritating to skin and mucous membranes. Option D: It may be irritating to skin and mucous membranes. " A 8640 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC=C2N Question about this molecule: Which kind of irritant is this molecule? Option A: It may slightly irritate skin, eyes, and mucous membranes. Option B: It strongly irritates skin, eyes, and mucous membranes. Option C: It slightly irritates skin, eyes, and mucous membranes. Option D: It may slightly irritate skin, eyes and mucous membranes. " C 7835 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C(O1)CCl Question about this molecule: Which kind of irritant is this molecule? Option A: It is irritating to the eyes, skin, and respiratory tract in humans. Option B: It is irritating to the skin, eyes, and mucous membranes in humans. Option C: It may be irritating to skin, eyes, and mucous membranes. Option D: It causes irritation to the eyes, respiratory tract, and skin. " D 12695 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(F)(F)F)C(F)(F)F Question about this molecule: Which kind of irritant is this molecule? Option A: It is an irritant to skin, eyes, and mucous membranes. Option B: It is an irritant to the skin, eyes, and mucous membranes. Option C: It is a strong irritant to skin, eyes, and mucous membranes. Option D: It is a strong irritant to the skin, eyes, and mucous membranes. " A 7768 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(=O)NCC1 Question about this molecule: Which kind of irritant is this molecule? Option A: It results in irritation of the eyes, nasal passages, throat, and lungs. Option B: It may result in irritation and burning of the eyes, nose, throat, and skin. Option C: It causes irritation to the eyes, respiratory tract, and skin. Option D: It is irritating to the eyes, skin, and respiratory tract in humans. " B 7966 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(CC1)O Question about this molecule: Which kind of irritant is this molecule? Option A: It irritates skin, eyes, and mucous membranes. Option B: It irritates the skin, eyes, and mucous membranes. Option C: It can irritate skin, eyes, and mucous membranes. Option D: It may irritate skin, eyes, and mucous membranes. " A 125468 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C=C(\\C)/C(=O)O Question about this molecule: Which kind of irritant is this molecule? Option A: It may slightly irritate skin, eyes, and mucous membranes. Option B: It may severely irritate skin, eyes, and mucous membranes. Option C: It may severely irritate skin, eyes, lungs, or mucous membranes. Option D: It may slightly irritate skin, eyes and mucous membranes. " C 281 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C-]#[O+] Question about this molecule: Which kind of irritant is this molecule? Option A: It is a mild irritant to skin and eyes. Option B: It is a strong irritant to skin and eyes. Option C: It is nonirritating. Option D: It is non-irritating to skin and minimally irritating to eyes. " C 6259 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(=O)CBr Question about this molecule: Which kind of irritant is this molecule? Option A: It is a skin and eye irritant. Option B: It is reported to be a mild skin or eye irritant. Option C: It is a severe eye irritant. Option D: It is a mild irritant to skin and eyes. " C 6581 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC(=O)O Question about this molecule: Which kind of irritant is this molecule? Option A: It is an irritant to skin, eyes, and mucous membranes. Option B: It is a strong irritant to the skin, eyes, and mucous membranes. Option C: It is a strong irritant to skin, eyes, and mucous membranes. Option D: It is an irritant to the skin, eyes, and mucous membranes. " B 222 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: N Question about this molecule: Which kind of irritant is this molecule? Option A: It is extremely irritating, especially to the eyes. Option B: It is irritating to the skin and eyes. Option C: It is irritating to the eyes. Option D: It is irritating to skin and eyes. " A 9033 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN1 Question about this molecule: Which kind of irritant is this molecule? Option A: It is a severe blistering agent, causing third degree chemical burns of the skin. Option B: It is a strong irritant to skin and eyes. Option C: It is a mild irritant to skin and eyes. Option D: It is reported to be a mild skin or eye irritant. " A 1322 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNNC Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate the skin, eyes, and mucous membranes. Option B: It may irritate skin, eyes and mucous membranes. Option C: It may irritate skin, eyes, and mucous membranes. Option D: It can irritate skin, eyes, and mucous membranes. " D 1032 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)O Question about this molecule: Which kind of irritant is this molecule? Option A: It is a strong irritant to the skin, eyes, and mucous membranes. Option B: It is an irritant but produces no acute systemic effects and has no demonstrable genotoxic potential. Option C: It is an irritant and inhalation may lead to hepatotoxic effects. Option D: It is a strong irritant to the eyes and mucous membranes and is toxic by inhalation. " B 2682 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCCCCCO Question about this molecule: Which kind of irritant is this molecule? Option A: It is a strong irritant to skin and eyes. Option B: It is a skin and eye irritant. Option C: It is a mild irritant to skin and eyes. Option D: It is reported to be a mild skin or eye irritant. " D 3485 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC=O)CC=O Question about this molecule: Which kind of irritant is this molecule? Option A: It is highly irritating to the skin, eyes, and mucous membranes in humans after acute inhalation or dermal exposures. Option B: It is toxic, causing severe eye, nose, throat and lung irritation, along with headaches, drowsiness and dizziness. Option C: Inhalation exposure may result in irritation of the nose and throat, and dermal exposure may irritate the skin. Option D: It causes irritation of the upper respiratory tract and eyes, sore throat, dizziness, and headache. " B 12232 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CSSC Question about this molecule: Which kind of irritant is this molecule? Option A: It may irritate skin and eyes. Option B: It irritates skin and eyes. Option C: It may irritate eyes and skin. Option D: Contact with it irritates skin and eyes. " A 4173 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NC=C(N1CCO)[N+](=O)[O-] Question about this molecule: What is the mechanism of this molecule's potency? Option A: It prevents the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling. Option B: It results in simultaneous NF-kappa beta suppression, Heat Shock Transcription Factor 1 (HSF1) suppression and p53 activation, and shows antitumour effects in animal models of various cancers. Option C: It exerts a protecting effect on neuronal cells through suppressing L-glutamate toxicity. Option D: It disrupts DNA helical structure, induces DNA strand breaks and inhibits bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death. " D 11794029 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@@H](C)C1=CC(=O)C2=C(O1)C3=C(C=C2CO)C(=O)C4=C(C3=O)C(=CC=C4)O Question about this molecule: What is the mechanism of this molecule's potency? Option A: It results in simultaneous NF-kappa beta suppression, Heat Shock Transcription Factor 1 (HSF1) suppression and p53 activation, and shows antitumour effects in animal models of various cancers. Option B: It disrupts DNA helical structure, induces DNA strand breaks and inhibits bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death. Option C: It prevents the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling. Option D: It exerts a protecting effect on neuronal cells through suppressing L-glutamate toxicity. " D 6437065 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](CO)NC(=O)[C@H]1CN([C@@H]2CC3=CNC4=CC=CC(=C34)C2=C1)C.C(=C\\C(=O)O)\\C(=O)O Question about this molecule: What is the mechanism of this molecule's potency? Option A: It results in simultaneous NF-kappa beta suppression, Heat Shock Transcription Factor 1 (HSF1) suppression and p53 activation, and shows antitumour effects in animal models of various cancers. Option B: It maintains uterine contraction and tone, compressing blood vessels in the uterine wall and reducing blood flow. Option C: It prevents the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling. Option D: It disrupts DNA helical structure, induces DNA strand breaks and inhibits bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death. " B 44519124 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCCN1C2=C(C=C(C=C2)C(=O)C)C3=C1C=CC(=C3)C(=O)C Question about this molecule: What is the mechanism of this molecule's potency? Option A: It disrupts DNA helical structure, induces DNA strand breaks and inhibits bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death. Option B: It exerts a protecting effect on neuronal cells through suppressing L-glutamate toxicity. Option C: It results in simultaneous NF-kappa beta suppression, Heat Shock Transcription Factor 1 (HSF1) suppression and p53 activation, and shows antitumour effects in animal models of various cancers. Option D: It prevents the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling. " C 60700 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O Question about this molecule: What is the mechanism of this molecule's potency? Option A: It works by binding to the topoisomerase I-DNA complex and preventing religation of these single strand breaks. Option B: It works by binding to Arp2/3 complex, stabilising the inactive state of the complex and preventing its movement into the active conformation. Option C: It prevents the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling. Option D: It disrupts DNA helical structure, induces DNA strand breaks and inhibits bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death. " A 135398739 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C[C@@H](O[C@@H]1CO)N2C=NC3=C2N=CNC3=O Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits nucleoside reverse transcriptase. Option B: It is a nucleoside reverse transcriptase inhibitor and cytochrome P450 1A1 inhibitor. Option C: It acts as a nucleoside reverse transcriptase inhibitor. Option D: It acts as a non-nucleoside reverse transcriptase inhibitor. " C 280 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)=O Question about this molecule: What is the mechanism of this molecule? Option A: It is an X-Ray Contrast Activity. Option B: It functions as a X-Ray Contrast Activity. Option C: It has a X-Ray Contrast Activity. Option D: It exhibits x-ray contrast activity. " D 441300 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)[C@@H]4C[C@@H](C=C4)CO Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a cytochrome P450 2D6 inhibitor. Option B: It is a nucleoside reverse transcriptase inhibitor and cytochrome P450 1A1 inhibitor. Option C: It serves as a histone deacetylase inhibitor and cytochrome P450 2D6 inhibitor. Option D: It acts as a P2Y12 receptor antagonist and a cytochrome P450 2C8 inhibitor. " B 6167 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a P2Y12 receptor antagonist and a cytochrome P450 2C8 inhibitor. Option B: It is a cytochrome P450 3A4 inhibitor and P-glycoprotein interaction. Option C: It is a cytochrome P450 2C9 inhibitor. Option D: It serves as a cytochrome P450 2D6 inhibitor. " B 119570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN[C@H]1CCC2=C(C1)SC(=N2)N Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a dopamine agonist. Option B: It functions as a Dopamine Agonist. Option C: It serves as a dopamine agonist. Option D: It acts as a dopamine D2 antagonist. " A 3005573 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCOC1=CC=C(C=C1)/C(=C(/CCCl)\\C2=CC=CC=C2)/C3=CC=CC=C3 Question about this molecule: What is the mechanism of this molecule? Option A: It has a gonadotropin releasing hormone receptor antagonist mechanism of action. Option B: It functions as an estrogen receptor antagonist and selective estrogen receptor modulator. Option C: It acts as a GABA A receptor positive modulator. Option D: It acts as a selective estrogen receptor modulator. " D 2520 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a non-nucleoside reverse transcriptase inhibitor, cytochrome P450 3A inducer, cytochrome P450 2B6 inducer, cytochrome P450 2C9 inhibitor, cytochrome P450 2C19 inhibitor, and cytochrome P450 3A4 inhibitor. Option B: It has a non-nucleoside reverse transcriptase inhibitor, cytochrome P450 3A inducer, cytochrome P450 2C9 inhibitor, cytochrome P450 2C19 inhibitor, and P-glycoprotein inhibitor mechanism of action. Option C: It is a calcium channel antagonist, cytochrome P450 3A4 inhibitor, cytochrome P450 3A inhibitor, and P-glycoprotein inhibitor. Option D: It inhibits Bcr-Abl tyrosine kinase, cytochrome P450 2C8, cytochrome P450 2D6, and UGT1A1, and it induces cytochrome P450 2B6 and cytochrome P450 2C8, and it inhibits P-glycoprotein. " C 2478 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CS(=O)(=O)OCCCCOS(=O)(=O)C Question about this molecule: What is the mechanism of this molecule? Option A: It has an alkylating activity. Option B: It has alkylating activity. Option C: It exhibits Methylating Activity. Option D: It has an alkylating activity mechanism of action. " B 5816 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC[C@@H](C1=CC(=C(C=C1)O)O)O Question about this molecule: What is the mechanism of this molecule? Option A: It serves as an adrenergic beta-antagonist. Option B: It serves as an adrenergic agonist. Option C: It acts as an adrenergic alpha-agonist and adrenergic beta-agonist. Option D: It serves as an adrenergic alpha-agonist. " C 2140 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)NC1=C(C(=C(C(=C1I)C(=O)O)I)NC(=O)C)I Question about this molecule: What is the mechanism of this molecule? Option A: It is an X-Ray Contrast Activity. Option B: It exhibits x-ray contrast activity. Option C: It has a X-Ray Contrast Activity. Option D: It functions as a X-Ray Contrast Activity. " B 54726191 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1CCO[C@@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O Question about this molecule: What is the mechanism of this molecule? Option A: It is a HIV Protease Inhibitor, P-Glycoprotein Inhibitor, Cytochrome P450 3A Inhibitor, and Organic Anion Transporting Polypeptide 1B1 Inhibitor. Option B: It serves as a HIV Integrase Inhibitor, Multidrug and Toxin Extrusion Transporter 1 Inhibitor, and Organic Cation Transporter 2 Inhibitor. Option C: It acts as a Cytochrome P450 3A4 Inhibitor, Organic Cation Transporter 2 Inhibitor, and P-Glycoprotein Inhibitor. Option D: It acts as a Dihydrofolate Reductase Inhibitor, Cytochrome P450 2C8 Inhibitor, and Organic Cation Transporter 2 Inhibitor. " B 4004 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)CC(C(=O)OCC)SP(=S)(OC)OC Question about this molecule: What is the mechanism of this molecule? Option A: It functions as a Cholinesterase Inhibitor. Option B: It exhibits Cholinesterase Inhibitor activity. Option C: It inhibits Cholinesterase. Option D: It functions as a Cholinesterase Reactivator. " A 297 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C Question about this molecule: What is the mechanism of this molecule? Option A: It halts weed growth, eventually killing the weed or causing it to die due to its incapability to compete with surrounding vegetation. Option B: It delivers mesalazine to the large intestine to act directly on ulcerative colitis. Option C: It works by binding to the poison in the gastric contents in a reversible fashion. Option D: It involves interference with the kinesin-related motor proteins in nerve cells or with fusion proteins in the formation of vesicles at the nerve terminus and eventual cell death. " C 1548887 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC\\1=C(C2=C(/C1=C\\C3=CC=C(C=C3)S(=O)C)C=CC(=C2)F)CC(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It has a cyclooxygenase inhibitor mechanism of action. Option B: It inhibits cyclooxygenase. Option C: It serves as a cyclooxygenase inhibitor. Option D: It has a 5-lipoxygenase inhibitor mechanism of action. " C 5280723 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1CCCCCCC(=O)O)O)O Question about this molecule: What is the mechanism of this molecule? Option A: It functions as a Prostaglandin Receptor Agonist. Option B: It acts as an Opioid mu-Receptor Agonist. Option C: It acts as a Serotonin 4 Receptor Agonist. Option D: It functions as a Serotonin 1b Receptor Agonist and Serotonin 1d Receptor Agonist. " A 3009 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(C(F)F)(C(=O)O)N)CN Question about this molecule: What is the mechanism of this molecule? Option A: It works as a Proteasome Inhibitor. Option B: It functions as a DOPA Decarboxylase Inhibitor. Option C: It acts as a Decarboxylase Inhibitor. Option D: It acts as a Proteasome Inhibitor. " C 441080 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@H]1[C@@H]2C[C@H]3[C@H]4[C@@]5(C[C@@H](C2[C@H]5O)N3[C@@H]1O)C6=CC=CC=C6N4C Question about this molecule: What is the mechanism of this molecule? Option A: It is a class Ia antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials. Option B: It depletes the neurotransmitter of painful impulses known as substance P from the sensory nerve terminals. Option C: It increases the threshold for electrical excitation in nerves by slowing the propagation of the nerve impulse and reducing the rate of rise of the action potential. Option D: It acts by preventing transmission of impulses along nerve fibers and at nerve endings. " A 135398747 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+]1=CC=CC=C1/C=N/O Question about this molecule: What is the mechanism of this molecule? Option A: It exhibits Cholinesterase Inhibitor activity. Option B: It functions as a Cholinesterase Reactivator. Option C: It inhibits Cholinesterase. Option D: It functions as a Cholinesterase Inhibitor. " B 3162 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C1=CC=CC=C1)(C2=CC=CC=N2)OCCN(C)C Question about this molecule: What is the mechanism of this molecule? Option A: It is a Histamine H1 Receptor Antagonist. Option B: It is a Histamine Receptor Antagonist. Option C: It serves as a Histamine Receptor Antagonist. Option D: It serves as a Histamine H1 Receptor Antagonist. " C 3345 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)N(C1CCN(CC1)CCC2=CC=CC=C2)C3=CC=CC=C3 Question about this molecule: What is the mechanism of this molecule? Option A: It acts as an Opioid mu-Receptor Agonist. Option B: It is a Full Opioid Agonist. Option C: It acts as a Competitive Opioid Antagonist and Partial Opioid Agonist. Option D: It acts as a Partial Opioid Agonist. " B 3736 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(CC(CO)O)C(=O)C1=C(C(=C(C(=C1I)C(=O)NCC(CO)O)I)NC(=O)COC)I Question about this molecule: What is the mechanism of this molecule? Option A: It is an X-Ray Contrast Activity. Option B: It has a X-Ray Contrast Activity. Option C: It exhibits Magnetic Resonance Contrast Activity. Option D: It functions as a X-Ray Contrast Activity. " D 2554 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2C(=O)N Question about this molecule: What is the mechanism of this molecule? Option A: It is a Cytochrome P450 3A Inhibitor, P-Glycoprotein Inhibitor, Cytochrome P450 1A2 Inhibitor, Cytochrome P450 2C9 Inhibitor, and Cytochrome P450 2D6 Inhibitor. Option B: It acts as a Cytochrome P450 1A2 Inducer, Cytochrome P450 2B6 Inducer, Cytochrome P450 2C8 Inducer, Cytochrome P450 2C19 Inducer, Cytochrome P450 2D6 Inducer, Cytochrome P450 3A Inducer, and Cytochrome P450 2C9 Inducer. Option C: It serves as a Cytochrome P450 3A4 Inducer, Cytochrome P450 1A2 Inducer, Cytochrome P450 2B6 Inducer, Cytochrome P450 2C9 Inducer, and Cytochrome P450 2C19 Inducer. Option D: It works as a Cytochrome P450 2C19 Inhibitor, Cytochrome P450 2C9 Inhibitor, Cytochrome P450 3A4 Inducer, and Cytochrome P450 2D6 Inducer. " C 3826 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Dipeptidase Inhibitor. Option B: It acts as a Lipase Inhibitor. Option C: It works as a Cyclooxygenase Inhibitor. Option D: It is a Cyclooxygenase Inhibitor. " D 2724354 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C@@H]([C@@H](C(=O)O)S)(C(=O)O)S Question about this molecule: What is the mechanism of this molecule? Option A: It exhibits Iron Chelating Activity. Option B: It exhibits Phosphate Chelating Activity. Option C: It serves as a Lead Chelating Activity. Option D: It has Acidifying Activity and Calcium Chelating Activity. " C 115355 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC(=O)C(C(=O)C1)C(=O)C2=C(C=C(C=C2)C(F)(F)F)[N+](=O)[O-] Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a hydroxyphenylpyruvate dioxygenase inhibitor, cytochrome P450 2C9 inhibitor, cytochrome P450 2E1 inducer, organic anion transporter 1 inhibitor, and organic anion transporter 3 inhibitor. Option B: It acts as a histone deacetylase inhibitor, bile salt export pump inhibitor, organic anion transporting polypeptide 1B1 inhibitor, organic anion transporting polypeptide 1B3 inhibitor, organic anion transporter 1 inhibitor, and organic cation transporter 2 inhibitor. Option C: It acts as a cytochrome P450 3A inhibitor, P-glycoprotein inhibitor, cytochrome P450 2D6 inhibitor, organic anion transporting polypeptide 1B1 inhibitor, organic anion transporting polypeptide 1B3 inhibitor, breast cancer resistance protein inhibitor, and multidrug and toxin extrusion transporter 1 inhibitor. Option D: It serves as an HCV NS3/4A protease inhibitor, cytochrome P450 3A inhibitor, P-glycoprotein inhibitor, organic anion transporting polypeptide 1B1 inhibitor, and organic anion transporting polypeptide 2B1 inhibitor. " A 10311306 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC[C@]2(CC[C@]3(CCC(=O)N3)CN2)C4=CC=CC=C4 Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a cytochrome P450 3A4 inhibitor, P-glycoprotein inhibitor, and breast cancer resistance protein inhibitor. Option B: It serves as a neurokinin 1 antagonist, cytochrome P450 2D6 inhibitor, breast cancer resistance protein inhibitor, and P-glycoprotein inhibitor. Option C: It has a non-nucleoside reverse transcriptase inhibitor, cytochrome P450 3A inducer, cytochrome P450 2C9 inhibitor, cytochrome P450 2C19 inhibitor, and P-glycoprotein inhibitor mechanism of action. Option D: It is a calcium channel antagonist, cytochrome P450 3A4 inhibitor, cytochrome P450 3A inhibitor, and P-glycoprotein inhibitor. " B 135398658 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)NC(=N3)N Question about this molecule: What is the mechanism of this molecule? Option A: Levoleucovorin and leucovorin act as cellular replacements for the co-factor tetrahydrofolate (THF) by bypassing DHFR reduction. Option B: It serves as a cytochrome P450 3A4 inhibitor, P-glycoprotein inhibitor, and breast cancer resistance protein inhibitor. Option C: It serves as a neurokinin 1 antagonist, cytochrome P450 2D6 inhibitor, breast cancer resistance protein inhibitor, and P-glycoprotein inhibitor. Option D: It inhibits the colony-stimulating factor (CSF1)/CSF1 receptor pathway as a selective tyrosine kinase inhibitor. " A 9941444 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@H](CN2[C@@H]1C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C2=O)CC3=CC=CC=C3)CC4=CC=C(C=C4)OCC5=CC=CC=C5)CCCCN)CC6=CNC7=CC=CC=C76)C8=CC=CC=C8)OC(=O)NCCN Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a melatonin receptor agonist. Option B: It serves as a somatostatin receptor agonist. Option C: It is a serotonin 1b receptor agonist and serotonin 1d receptor agonist. Option D: It acts as a GABA A agonist and GABA B agonist. " B 6918837 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO Question about this molecule: What is the mechanism of this molecule? Option A: It is a proton pump inhibitor and cytochrome P450 2C19 inhibitor. Option B: It acts as a P2Y12 receptor antagonist and a cytochrome P450 2C8 inhibitor. Option C: It serves as a cytochrome P450 2D6 inhibitor. Option D: It serves as a histone deacetylase inhibitor and cytochrome P450 2D6 inhibitor. " D 4828 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(COC1=CC=CC2=C1C=CN2)O Question about this molecule: What is the mechanism of this molecule? Option A: It serves as an adrenergic alpha-agonist. Option B: It serves as an adrenergic agonist. Option C: It acts as an adrenergic alpha-agonist and adrenergic beta-agonist. Option D: It serves as an adrenergic beta-antagonist. " D 5281004 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC1O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@@]5([C@H]4[C@H](C[C@@]3([C@@]2(O1)C(=O)CO)C)O)C Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a prostaglandin receptor agonist. Option B: It acts as a corticosteroid hormone receptor agonist. Option C: It agonizes corticosteroid hormone receptors. Option D: It serves as a corticosteroid hormone receptor agonist. " D 9868491 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)OC(=O)CCC/C=C\\C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/C(COC2=CC=CC=C2)(F)F)O)O Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a prostaglandin receptor agonist. Option B: It serves as an adrenergic agonist. Option C: It serves as an adrenergic beta-antagonist. Option D: It serves as a somatostatin receptor agonist. " A 7027 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@@H]1[C@H]([C@@H]([C@H](C(=O)O1)O)O)O)O Question about this molecule: What is the mechanism of this molecule? Option A: It serves as an irrigation. Option B: It serves as an adrenergic beta-antagonist. Option C: It serves as an adrenergic alpha-agonist. Option D: It serves as an adrenergic agonist. " A 700 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CO)N Question about this molecule: What is the mechanism of this molecule? Option A: It has sclerosing activity. Option B: It has Oxidation-Reduction Activity. Option C: It has an Osmotic Activity. Option D: It has Osmotic Activity. " A 785 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1O)O Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits protein kinase. Option B: It inhibits kinases. Option C: It inhibits melanin synthesis. Option D: It inhibits protein synthesis. " C 6178111 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)N=C(N)/N=C(\\N)/NC1=CC=C(C=C1)Cl Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits dihydrofolate reductase. Option B: It serves as a cyclooxygenase inhibitor. Option C: It inhibits cyclooxygenase. Option D: It has a cyclooxygenase inhibitor mechanism of action. " A 2733526 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC/C(=C(\\C1=CC=CC=C1)/C2=CC=C(C=C2)OCCN(C)C)/C3=CC=CC=C3 Question about this molecule: What is the mechanism of this molecule? Option A: It has a gonadotropin releasing hormone receptor antagonist mechanism of action. Option B: It acts as a selective estrogen receptor modulator. Option C: It acts as a GABA A receptor positive modulator. Option D: It functions as an estrogen receptor antagonist and selective estrogen receptor modulator. " B 25154714 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[C@@H](C(=O)N1CCC[C@H]1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)[C@@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)OC)NC(=O)OC Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits P-glycoprotein, organic anion transporting polypeptide 1B1, organic anion transporting polypeptide 1B3, and breast cancer resistance protein. Option B: It serves as an HCV NS3/4A protease inhibitor, cytochrome P450 3A inhibitor, P-glycoprotein inhibitor, organic anion transporting polypeptide 1B1 inhibitor, and organic anion transporting polypeptide 2B1 inhibitor. Option C: It acts as a histone deacetylase inhibitor, bile salt export pump inhibitor, organic anion transporting polypeptide 1B1 inhibitor, organic anion transporting polypeptide 1B3 inhibitor, organic anion transporter 1 inhibitor, and organic cation transporter 2 inhibitor. Option D: It serves as a hydroxyphenylpyruvate dioxygenase inhibitor, cytochrome P450 2C9 inhibitor, cytochrome P450 2E1 inducer, organic anion transporter 1 inhibitor, and organic anion transporter 3 inhibitor. " A 5291 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5 Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits HCV NS3/4A protease, cytochrome P450 3A4, and cytochrome P450 3A5. Option B: It acts as a non-nucleoside reverse transcriptase inhibitor, cytochrome P450 3A inducer, cytochrome P450 2B6 inducer, cytochrome P450 2C9 inhibitor, cytochrome P450 2C19 inhibitor, and cytochrome P450 3A4 inhibitor. Option C: It inhibits Bcr-Abl tyrosine kinase, cytochrome P450 3A4, and cytochrome P450 2D6. Option D: It inhibits Bcr-Abl tyrosine kinase, cytochrome P450 2C8, cytochrome P450 2D6, and UGT1A1, and it induces cytochrome P450 2B6 and cytochrome P450 2C8, and it inhibits P-glycoprotein. " C 5910 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@H]1[C@H](COC1=O)CC2=CN=CN2C Question about this molecule: What is the mechanism of this molecule? Option A: It functions as a cholinergic muscarinic antagonist. Option B: It acts as a cholinergic agonist and cholinergic muscarinic agonist. Option C: It has a partial cholinergic nicotinic agonist and cholinergic agonist mechanism of action. Option D: It acts as a cholinergic agonist. " B 41867 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits topoisomerase. Option B: It inhibits DNA Polymerase. Option C: It inhibits DNA-dependent RNA polymerase. Option D: It functions as a DNA Polymerase Inhibitor. " A 157355 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O[C@H]([C@@H](CO)O)[C@@H]([C@H](CO)O)O)O)O)O)O Question about this molecule: What is the mechanism of this molecule? Option A: It has an Osmotic Activity. Option B: It has Osmotic Activity. Option C: It works through Osmotic Activity. Option D: It has an Ammonium Ion Binding Activity. " B 9294 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]([C@@H](C1=CC=CC=C1)O)NC Question about this molecule: What is the mechanism of this molecule? Option A: It serves as an adrenergic agonist. Option B: It serves as an adrenergic beta-antagonist. Option C: It acts as an adrenergic alpha-agonist and adrenergic beta-agonist. Option D: It serves as an adrenergic alpha-agonist. " C 92786 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(CC[C@H](C4)O)C)C Question about this molecule: What is the mechanism of this molecule? Option A: It functions as an estrogen receptor antagonist and selective estrogen receptor modulator. Option B: It has a gonadotropin releasing hormone receptor antagonist mechanism of action. Option C: It acts as a GABA A receptor positive modulator. Option D: It acts as a selective estrogen receptor modulator. " C 5481173 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C(=O)O)O/N=C(/C1=CSC(=N1)N)\\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C[N+]4=CC=CC=C4)C(=O)[O-] Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits urate crystal deposition, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Option B: It inhibits essential PBPs, resulting in impaired cell wall homeostasis, loss of cell integrity, and bacterial cell death. Option C: It acts indirectly on reticular formation, reducing neuronal activity into reticular formation without affecting its intrinsic ability to activate the cerebral cortex. Option D: It alters signal conduction in neurons by blocking fast voltage-gated sodium (Na+) channels in the neuronal cell membrane responsible for signal propagation. " B 10964 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C=O)C=O Question about this molecule: What is the mechanism of this molecule? Option A: The hypotensive effects are not necessarily due to its diuretic activity. Option B: It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent. Option C: It is a class Ia antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials. Option D: It is based on successive hydroperoxide formation and _-cleavage of polyunsaturated fatty acids. " D 4095 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2 Question about this molecule: What is the mechanism of this molecule? Option A: It acts as an Opioid mu-Receptor Agonist. Option B: It is a Full Opioid Agonist. Option C: It acts as a Partial Opioid Agonist. Option D: It acts as a Competitive Opioid Antagonist and Partial Opioid Agonist. " B 6049 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CN(CC(=O)O)CC(=O)O)N(CC(=O)O)CC(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It has lead chelating activity and calcium chelating activity. Option B: It has metal chelating activity. Option C: It has alkylating activity. Option D: It has Acidifying Activity and Calcium Chelating Activity. " A 9639 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(C(C(F)(F)F)(F)F)(F)F)(C(C(F)(F)F)(F)F)(F)F Question about this molecule: What is the mechanism of this molecule? Option A: It exhibits Magnetic Resonance Contrast Activity. Option B: It has a positron emitting activity mechanism. Option C: It exhibits positron emitting activity. Option D: It has ultrasound contrast activity. " D 447715 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@@H]1[C@@H]2C[C@@H](CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3[C@@H]1O)CC[C@@H]4[C@H](C)CCC(=O)O)C)C)O Question about this molecule: What is the mechanism of this molecule? Option A: It acts as an Opioid mu-Receptor Agonist. Option B: It functions as a Serotonin 1b Receptor Agonist and Serotonin 1d Receptor Agonist. Option C: It acts as a Farnesoid X Receptor Agonist. Option D: It acts as a Serotonin 4 Receptor Agonist. " C 2833 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC Question about this molecule: What is the mechanism of this molecule? Option A: It binds strongly to hydroxyapatite crystals in the bone matrix, preferentially at the sites of increased bone turnover, and inhibits the formation and dissolution of the crystals. Option B: It activates 5-HT1D receptors on intracranial blood vessels, leading to vasoconstriction, and activates 5-HT1D receptors on sensory nerve endings of the trigeminal system, resulting in the inhibition of pro-inflammatory neuropeptide release. Option C: It has a high affinity for 5-HTA1 and 5-HTA2 receptors, displaying agonist activity on 5-HTA1 and antagonist on 5-HTA2, resulting in lowering of serotonin in the brain as well as an effect on increasing norepinephrine and dopamine neurotransmitters. Option D: It inhibits urate crystal deposition, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. " D 5281081 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)C(=O)/C(=C/C1=CC(=C(C(=C1)O)O)[N+](=O)[O-])/C#N Question about this molecule: What is the mechanism of this molecule? Option A: It works as a Catechol O-Methyltransferase Inhibitor. Option B: It acts as a Dipeptidase Inhibitor. Option C: It acts as a Neuraminidase Inhibitor. Option D: It acts as a Catechol O-Methyltransferase Inhibitor. " D 5486971 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C[C@@H](CC(=O)O)CN Question about this molecule: What is the mechanism of this molecule? Option A: It exerts its effects by binding to the α2δ subunit of voltage-dependent calcium channels. Option B: It can decrease intracellular calcium levels by inhibiting calcium influx through voltage-gated calcium channels. Option C: It alters signal conduction in neurons by blocking fast voltage-gated sodium (Na+) channels in the neuronal cell membrane responsible for signal propagation. Option D: It inhibits repeated neuronal firing and stabilizes the inactivated state of voltage-gated sodium channels. " A 17358 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: FS(F)(F)(F)(F)F Question about this molecule: What is the mechanism of this molecule? Option A: It is an X-Ray Contrast Activity. Option B: It has a X-Ray Contrast Activity. Option C: It exhibits Magnetic Resonance Contrast Activity. Option D: It has an Ultrasound Contrast Activity. " D 5358 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C Question about this molecule: What is the mechanism of this molecule? Option A: It is a serotonin 1b receptor agonist and serotonin 1d receptor agonist. Option B: It acts as a Serotonin Uptake Inhibitor. Option C: It functions as a Serotonin 1b Receptor Agonist and Serotonin 1d Receptor Agonist. Option D: It acts as a Serotonin 4 Receptor Agonist. " A 4775 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)CCCC(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It has an Ammonium Ion Binding Activity. Option B: It has an Osmotic Activity. Option C: It has Osmotic Activity. Option D: It works through Osmotic Activity. " A 923 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Na+] Question about this molecule: What is the mechanism of this molecule? Option A: It has an Ammonium Ion Binding Activity. Option B: It works through Osmotic Activity. Option C: It has Osmotic Activity. Option D: It has an Osmotic Activity. " D 667490 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC2=C(N1)C(=S)N=CN2 Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a Nucleoside Reverse Transcriptase Inhibitor. Option B: It functions as a Nucleic Acid Synthesis Inhibitor. Option C: It acts as a Lipase Inhibitor. Option D: It acts as a Nucleic Acid Synthesis Inhibitor. " D 6451164 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)/C=C/C#N Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a non-nucleoside reverse transcriptase inhibitor. Option B: It acts as a nucleoside reverse transcriptase inhibitor. Option C: It inhibits nucleoside reverse transcriptase. Option D: It is a nucleoside reverse transcriptase inhibitor and cytochrome P450 1A1 inhibitor. " A 5732 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)C2=C(N3C=C(C=CC3=N2)C)CC(=O)N(C)C Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Partial Opioid Agonist. Option B: It is a GABA A Agonist. Option C: It acts as a Competitive Opioid Antagonist and Partial Opioid Agonist. Option D: It is a Full Opioid Agonist. " B 6013 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=CC(=O)CC[C@]34C Question about this molecule: What is the mechanism of this molecule? Option A: It is an Androgen Receptor Agonist. Option B: It is an Estrogen Receptor Agonist. Option C: It acts as an Androgen Receptor Antagonist. Option D: It works as an Estrogen Receptor Agonist. " A 65028 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(CC)O[C@@H]1C=C(C[C@@H]([C@H]1NC(=O)C)N)C(=O)OCC Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Neuraminidase Inhibitor. Option B: It acts as a Lipase Inhibitor. Option C: It acts as a Proton Pump Inhibitor. Option D: It functions as a Proton Pump Inhibitor. " A 6579 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC(=O)N Question about this molecule: What is the mechanism of this molecule? Option A: It alters signal conduction in neurons by blocking fast voltage-gated sodium (Na+) channels in the neuronal cell membrane responsible for signal propagation. Option B: It involves interference with the kinesin-related motor proteins in nerve cells or with fusion proteins in the formation of vesicles at the nerve terminus and eventual cell death. Option C: It lowers blood glucose by increasing the secretion of insulin from the pancreas and increasing the sensitivity of peripheral tissues to insulin. Option D: It stimulates the secretion of insulin granules from pancreatic islet beta cells by blocking ATP-sensitive potassium channels (KATP channels) and causing depolarization of the beta cells. " B 2337 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C1=CC=C(C=C1)N Question about this molecule: What is the mechanism of this molecule? Option A: It depletes the neurotransmitter of painful impulses known as substance P from the sensory nerve terminals. Option B: It is a class Ia antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials. Option C: It acts by preventing transmission of impulses along nerve fibers and at nerve endings. Option D: It increases the threshold for electrical excitation in nerves by slowing the propagation of the nerve impulse and reducing the rate of rise of the action potential. " C 2141 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CN)CNCCSP(=O)(O)O Question about this molecule: What is the mechanism of this molecule? Option A: It has a Free Radical Scavenging Activity. Option B: It acts as a Smoothened Receptor Antagonist. Option C: It exhibits Magnetic Resonance Contrast Activity. Option D: It acts as a Progestational Hormone Receptor Antagonist. " A 5284603 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)OC)O4)O Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Competitive Opioid Antagonist and Partial Opioid Agonist. Option B: It acts as an Opioid mu-Receptor Agonist. Option C: It is a Full Opioid Agonist. Option D: It acts as a Partial Opioid Agonist. " C 243 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It has an Ammonium Ion Binding Activity. Option B: It has an Osmotic Activity. Option C: It works through Osmotic Activity. Option D: It has Osmotic Activity. " A 2083 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)NCC(C1=CC(=C(C=C1)O)CO)O Question about this molecule: What is the mechanism of this molecule? Option A: It acts as an Adrenergic beta2-Agonist. Option B: It is an Adrenergic beta3-Agonist. Option C: It acts as an Adrenergic beta-Agonist. Option D: It works as an Adrenergic alpha2-Agonist. " A 2366 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNCCC1=CC=CC=N1 Question about this molecule: What is the mechanism of this molecule? Option A: It acts on histamine receptors. Option B: It antagonizes histamine H1 receptors. Option C: It antagonizes adenosine A3 receptors. Option D: It antagonizes histamine H2 receptors. " A 5282448 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CO[C@@H]1[C@@H]([C@H]([C@@H]([C@H](O1)COS(=O)(=O)O)O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](O2)C(=O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)COS(=O)(=O)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)C(=O)O)O[C@@H]5[C@@H]([C@H]([C@@H]([C@H](O5)COS(=O)(=O)O)O)O)NS(=O)(=O)O)O)O)OS(=O)(=O)O)NS(=O)(=O)O)O)OS(=O)(=O)O)O)NS(=O)(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It is a Protein Kinase Inhibitor. Option B: It inhibits Factor Xa. Option C: It acts as a Factor Xa Inhibitor. Option D: It works as a Protein Kinase Inhibitor. " C 6741 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)C=C4)C)O)C)(C(=O)CO)O Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a prostaglandin receptor agonist. Option B: It agonizes corticosteroid hormone receptors. Option C: It serves as a corticosteroid hormone receptor agonist. Option D: It acts as a corticosteroid hormone receptor agonist. " D 3036505 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)/C(=C(/C2=CC=CC=C2)\\C3=CC=C(C=C3)OCCO)/CCCl Question about this molecule: What is the mechanism of this molecule? Option A: It has a gonadotropin releasing hormone receptor antagonist mechanism of action. Option B: It acts as a selective estrogen receptor modulator. Option C: It acts as a GABA A receptor positive modulator. Option D: It functions as an estrogen receptor antagonist and selective estrogen receptor modulator. " B 3038 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1S(=O)(=O)N)Cl)Cl)S(=O)(=O)N Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a Carbonic Anhydrase Inhibitor. Option B: It is a Carbonic Anhydrase Inhibitor. Option C: It acts as a Carbonic Anhydrase Inhibitor and P-Glycoprotein Inhibitor. Option D: It acts as a Dipeptidase Inhibitor. " B 3869 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CCC1=CC=CC=C1)NCC(C2=CC(=C(C=C2)O)C(=O)N)O Question about this molecule: What is the mechanism of this molecule? Option A: It serves as an adrenergic alpha-agonist. Option B: It serves as an adrenergic beta-antagonist. Option C: It is an adrenergic beta-antagonist. Option D: It is an adrenergic alpha-agonist. " C 3730 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)N(CC(CO)O)C1=C(C(=C(C(=C1I)C(=O)NCC(CO)O)I)C(=O)NCC(CO)O)I Question about this molecule: What is the mechanism of this molecule? Option A: It functions as a X-Ray Contrast Activity. Option B: It is an X-Ray Contrast Activity. Option C: It exhibits Magnetic Resonance Contrast Activity. Option D: It has a X-Ray Contrast Activity. " D 3062316 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO Question about this molecule: What is the mechanism of this molecule? Option A: It is a Protein Kinase Inhibitor and Cytochrome P450 3A4 Inhibitor. Option B: It works as a HIV Protease Inhibitor and Cytochrome P450 3A Inhibitor. Option C: It is a Serotonin Uptake Inhibitor and Cytochrome P450 2D6 Inhibitor. Option D: It is a Kinase Inhibitor and Cytochrome P450 3A Inhibitor. " A 5311052 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@H]1C(=O)CO)C)O)Cl)C)F Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a corticosteroid hormone receptor agonist. Option B: It agonizes corticosteroid hormone receptors. Option C: It serves as a prostaglandin receptor agonist. Option D: It acts as a corticosteroid hormone receptor agonist. " D 6442177 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OCCO)C)/C)O)OC)C)C)/C)OC Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Cytochrome P450 2C19 Inhibitor, Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C9 Inhibitor. Option B: It acts as a Tyrosine Kinase Inhibitor, Cytochrome P450 3A Inhibitor, and Cytochrome P450 2C9 Inhibitor. Option C: It is a Protein Kinase Inhibitor, Cytochrome P450 3A4 Inhibitor, Cytochrome P450 2D6 Inhibitor, and Cytochrome P450 2C8 Inhibitor. Option D: It is a Protein Kinase Inhibitor, Cytochrome P450 3A4 Inhibitor, Cytochrome P450 2D6 Inhibitor, and mTOR Inhibitor. " D 2130 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C2CC3CC1CC(C2)(C3)N Question about this molecule: What is the mechanism of this molecule? Option A: It is a M2 Protein Inhibitor. Option B: It acts as a Lipase Inhibitor. Option C: It is a Protein Kinase Inhibitor. Option D: It works as a Protein Kinase Inhibitor. " A 5311066 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CO)CCC5=CC(=O)C=C[C@]35C)O Question about this molecule: What is the mechanism of this molecule? Option A: It agonizes corticosteroid hormone receptors. Option B: It serves as a prostaglandin receptor agonist. Option C: It serves as a corticosteroid hormone receptor agonist. Option D: It acts as a corticosteroid hormone receptor agonist. " D 107807 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC[C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It works as an Angiotensin-converting Enzyme Inhibitor. Option B: It acts as an angiotensin 2 receptor antagonist. Option C: It is an Angiotensin-converting Enzyme Inhibitor. Option D: It works as an Angiotensin 2 Receptor Antagonist. " C 3739 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=C(C(=C1I)NC(=O)CCCCC(=O)NC2=C(C=C(C(=C2I)C(=O)O)I)I)I)C(=O)O)I Question about this molecule: What is the mechanism of this molecule? Option A: It exhibits Magnetic Resonance Contrast Activity. Option B: It functions as a X-Ray Contrast Activity. Option C: It has a X-Ray Contrast Activity. Option D: It is an X-Ray Contrast Activity. " D 71415 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C)F Question about this molecule: What is the mechanism of this molecule? Option A: It agonizes corticosteroid hormone receptors. Option B: It acts as a corticosteroid hormone receptor agonist. Option C: It serves as a prostaglandin receptor agonist. Option D: It serves as a corticosteroid hormone receptor agonist. " B 449688 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+](C)([11CH3])CCO Question about this molecule: What is the mechanism of this molecule? Option A: It is a Radiopharmaceutical Activity. Option B: It exhibits Radiopharmaceutical Activity. Option C: It has a radiopharmaceutical activity mechanism of action. Option D: It exhibits Magnetic Resonance Contrast Activity. " A 38853 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)O)N Question about this molecule: What is the mechanism of this molecule? Option A: It is an Adrenergic alpha2-Agonist. Option B: It acts as an Adrenergic beta2-Agonist. Option C: It works as an Adrenergic alpha2-Agonist. Option D: It acts as an Adrenergic alpha1-Agonist. " A 10472693 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(CCCCCC(CCCCCC(C)(C)C(=O)O)O)C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Lipase Inhibitor. Option B: It is an Adenosine Triphosphate-Citrate Lyase Inhibitor. Option C: It is an Aromatase Inhibitor. Option D: It works as a Proteasome Inhibitor. " B 35370 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)N=[N+]=[N-] Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits nucleoside reverse transcriptase. Option B: It acts as a nucleoside reverse transcriptase inhibitor. Option C: It is a nucleoside reverse transcriptase inhibitor and cytochrome P450 1A1 inhibitor. Option D: It acts as a non-nucleoside reverse transcriptase inhibitor. " B 6256 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a Nucleoside Reverse Transcriptase Inhibitor. Option B: It functions as a Nucleic Acid Synthesis Inhibitor. Option C: It acts as a Lipase Inhibitor. Option D: It acts as a Nucleic Acid Synthesis Inhibitor. " D 68617 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN[C@H]1CC[C@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl Question about this molecule: What is the mechanism of this molecule? Option A: It is a P2Y12 Receptor Antagonist, Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor. Option B: It acts as a Serotonin 2c Receptor Agonist and Cytochrome P450 2D6 Inhibitor. Option C: It is a Serotonin Uptake Inhibitor and Cytochrome P450 2D6 Inhibitor. Option D: It acts as a Vasopressin Receptor Antagonist and Cytochrome P450 3A Inhibitor. " C 36811 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CCC1=CC=C(C=C1)O)NCCC2=CC(=C(C=C2)O)O Question about this molecule: What is the mechanism of this molecule? Option A: It acts as an Adrenergic beta-Agonist. Option B: It works as an Adrenergic alpha2-Agonist. Option C: It acts as an Adrenergic beta2-Agonist. Option D: It is an Adrenergic beta3-Agonist. " A 137 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(=O)O)C(=O)CN Question about this molecule: What is the mechanism of this molecule? Option A: It has a X-Ray Contrast Activity. Option B: It is a Fluorescence Contrast Activity. Option C: It exhibits Magnetic Resonance Contrast Activity. Option D: It has an Ultrasound Contrast Activity. " B 3394 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It works as a Cyclooxygenase Inhibitor. Option B: It acts as a Lipase Inhibitor. Option C: It is a Cyclooxygenase Inhibitor. Option D: It acts as a Dipeptidase Inhibitor. " C 5362119 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C[C@H](N(C1)C(=O)[C@H](CCCCN)N[C@@H](CCC2=CC=CC=C2)C(=O)O)C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It is an Angiotensin-converting Enzyme Inhibitor. Option B: It works as an Angiotensin 2 Receptor Antagonist. Option C: It acts as an angiotensin 2 receptor antagonist. Option D: It works as an Angiotensin-converting Enzyme Inhibitor. " A 4054 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC12CC3CC(C1)(CC(C3)(C2)N)C Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Smoothened Receptor Antagonist. Option B: It is a Histamine Receptor Antagonist. Option C: It serves as a Histamine Receptor Antagonist. Option D: It is an NMDA Receptor Antagonist. " D 1548943 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC Question about this molecule: What is the mechanism of this molecule? Option A: It acts by preventing transmission of impulses along nerve fibers and at nerve endings. Option B: It increases the threshold for electrical excitation in nerves by slowing the propagation of the nerve impulse and reducing the rate of rise of the action potential. Option C: It depletes the neurotransmitter of painful impulses known as substance P from the sensory nerve terminals. Option D: It is a class Ia antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials. " C 45375808 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3 Question about this molecule: What is the mechanism of this molecule? Option A: It is an RNA Replicase Inhibitor. Option B: It acts as a DNA Polymerase Inhibitor. Option C: It functions as a DNA Polymerase Inhibitor. Option D: It is a Topoisomerase Inhibitor. " A 10184653 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4 Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Lipase Inhibitor. Option B: It works as a Proteasome Inhibitor. Option C: It is a Protein Kinase Inhibitor. Option D: It works as a Protein Kinase Inhibitor. " C 60838 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7 Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a DNA Polymerase Inhibitor. Option B: It functions as a DNA Polymerase Inhibitor. Option C: It is a Topoisomerase Inhibitor. Option D: It works as a Proteasome Inhibitor. " C 2725 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2 Question about this molecule: What is the mechanism of this molecule? Option A: It is a Histamine Receptor Antagonist. Option B: It serves as a Histamine Receptor Antagonist. Option C: It is a Histamine H1 Receptor Antagonist. Option D: It serves as a Histamine H1 Receptor Antagonist. " C 4212 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO Question about this molecule: What is the mechanism of this molecule? Option A: It is a Topoisomerase Inhibitor. Option B: It works as a Proteasome Inhibitor. Option C: It functions as a DNA Polymerase Inhibitor. Option D: It acts as a DNA Polymerase Inhibitor. " A 4139 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C1=CC2=C(C=C1)N=C3C=CC(=[N+](C)C)C=C3S2 Question about this molecule: What is the mechanism of this molecule? Option A: It has Oxidation-Reduction Activity. Option B: It has Osmotic Activity. Option C: It works through Osmotic Activity. Option D: It has an Osmotic Activity. " A 3658 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(CCN1CCOCCO)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a Histamine Receptor Antagonist. Option B: It serves as a Histamine H1 Receptor Antagonist. Option C: It is a Histamine H1 Receptor Antagonist. Option D: It is a Histamine Receptor Antagonist. " D 10661 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C2=C(C(=O)N(C1=O)C)NC(=N2)Cl Question about this molecule: What is the mechanism of this molecule? Option A: It blocks the adenosine receptor. Option B: It antagonizes adenosine A3 receptors. Option C: It antagonizes Protease-activated Receptor-1. Option D: It antagonizes smoothened receptors. " A 107970 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N Question about this molecule: What is the mechanism of this molecule? Option A: It is a Sphingosine 1-Phosphate Receptor Modulator. Option B: It serves as a Histamine Receptor Antagonist. Option C: It is a Histamine Receptor Antagonist. Option D: It acts as a Smoothened Receptor Antagonist. " A 259331 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)OC(=O)N(CCCl)CCCl Question about this molecule: What is the mechanism of this molecule? Option A: It exhibits Methylating Activity. Option B: It has an alkylating activity. Option C: It has an alkylating activity mechanism of action. Option D: It has alkylating activity. " B 60953 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCOC(=O)NC1=NC(=O)N(C=C1F)[C@H]2[C@@H]([C@@H]([C@H](O2)C)O)O Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits protein kinase. Option B: It inhibits nucleic acid synthesis. Option C: It inhibits melanin synthesis. Option D: It inhibits protein synthesis. " B 2907 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CNP(=O)(OC1)N(CCCl)CCCl Question about this molecule: What is the mechanism of this molecule? Option A: It exhibits Methylating Activity. Option B: It has alkylating activity. Option C: It has an alkylating activity mechanism of action. Option D: It has an alkylating activity. " D 4044 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=CC=C1)NC2=CC=CC=C2C(=O)O)C Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits cyclooxygenase. Option B: It has a 5-lipoxygenase inhibitor mechanism of action. Option C: It has a cyclooxygenase inhibitor mechanism of action. Option D: It serves as a cyclooxygenase inhibitor. " A 30323 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O Question about this molecule: What is the mechanism of this molecule? Option A: It functions as a DNA Polymerase Inhibitor. Option B: It inhibits DNA-dependent RNA polymerase. Option C: It inhibits DNA Polymerase. Option D: It inhibits topoisomerase. " D 11499245 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: B1(C2=C(CO1)C=C(C=C2)F)O Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits Janus kinase. Option B: It inhibits protein synthesis. Option C: It inhibits kinases. Option D: It inhibits protein kinase. " B 5743 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a corticosteroid hormone receptor agonist. Option B: It serves as a prostaglandin receptor agonist. Option C: It agonizes corticosteroid hormone receptors. Option D: It serves as a corticosteroid hormone receptor agonist. " C 2756 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(N=CN1)CSCCNC(=NC)NC#N Question about this molecule: What is the mechanism of this molecule? Option A: It antagonizes histamine H1 receptors. Option B: It antagonizes smoothened receptors. Option C: It antagonizes adenosine A3 receptors. Option D: It antagonizes histamine H2 receptors. " D 5464097 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](C(=O)N1[C@H]2CCCC[C@@H]2C[C@H]1C(=O)O)N[C@@H](CCC3=CC=CC=C3)C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It works as an Angiotensin-converting Enzyme Inhibitor. Option B: It works as an Angiotensin 2 Receptor Antagonist. Option C: It inhibits angiotensin-converting enzyme. Option D: It has an angiotensin-converting enzyme inhibitor mechanism of action. " C 2082 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCSC1=CC2=C(C=C1)N=C(N2)NC(=O)OC Question about this molecule: What is the mechanism of this molecule? Option A: It induces cytochrome P450 1A. Option B: It is a cytochrome P450 2C9 inhibitor. Option C: It serves as a cytochrome P450 2D6 inhibitor. Option D: It is a cytochrome P450 3A4 inhibitor and P-glycoprotein interaction. " A 216210 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C2=C(C=C(C=C2)C(=O)N(CCC(=O)O)C3=CC=CC=N3)N=C1CNC4=CC=C(C=C4)C(=N)N Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits protein kinase. Option B: It inhibits protein synthesis. Option C: It inhibits thrombin. Option D: It inhibits melanin synthesis. " C 82153 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CO)C[C@@H](C5=CC(=O)C=C[C@]35C)F)O Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a corticosteroid hormone receptor agonist. Option B: It agonizes corticosteroid hormone receptors. Option C: It acts as a corticosteroid hormone receptor agonist. Option D: It serves as a prostaglandin receptor agonist. " C 460612 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C[C@@H](C(=O)O)N)N(CCCl)CCCl Question about this molecule: What is the mechanism of this molecule? Option A: It has an alkylating activity mechanism of action. Option B: It exhibits Methylating Activity. Option C: It has alkylating activity. Option D: It has an alkylating activity. " C 5487427 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+]1([C@@H]2CC(C[C@H]1[C@H]3[C@@H]2O3)OC(=O)C(C4=CC=CS4)(C5=CC=CS5)O)C Question about this molecule: What is the mechanism of this molecule? Option A: It functions as a cholinergic muscarinic antagonist. Option B: It acts as a cholinergic antagonist. Option C: It has a cholinergic antagonist mechanism of action. Option D: It serves as a cholinergic antagonist. " B 5284596 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O Question about this molecule: What is the mechanism of this molecule? Option A: It acts as an Opioid mu-Receptor Agonist. Option B: It acts as an Opioid Antagonist. Option C: It acts as a Partial Opioid Agonist. Option D: It acts as a Competitive Opioid Antagonist and Partial Opioid Agonist. " B 441244 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CN=C(N=C1)[N-]S(=O)(=O)C2=CC=C(C=C2)N.[Ag+] Question about this molecule: What is the mechanism of this molecule? Option A: The mechanism of action on bacteria differs from silver nitrate and sodium sulfadiazine. Option B: It alters signal conduction in neurons by blocking fast voltage-gated sodium (Na+) channels in the neuronal cell membrane responsible for signal propagation. Option C: The mechanism is less well understood, but it may involve its action on carbonic anhydrases in the smooth muscle or its action on the large-conductance calcium-activated potassium (KCa) channel. Option D: It inhibits repeated neuronal firing and stabilizes the inactivated state of voltage-gated sodium channels. " A 8223 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@]1(C(=O)N2[C@H](C(=O)N3CCC[C@H]3[C@@]2(O1)O)CC4=CC=CC=C4)NC(=O)[C@H]5CN([C@@H]6CC7=CNC8=CC=CC(=C78)C6=C5)C Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a cytochrome P450 3A inhibitor, P-glycoprotein inhibitor, cytochrome P450 2D6 inhibitor, organic anion transporting polypeptide 1B1 inhibitor, organic anion transporting polypeptide 1B3 inhibitor, breast cancer resistance protein inhibitor, and multidrug and toxin extrusion transporter 1 inhibitor. Option B: It has a high affinity for 5-HTA1 and 5-HTA2 receptors, displaying agonist activity on 5-HTA1 and antagonist on 5-HTA2, resulting in lowering of serotonin in the brain as well as an effect on increasing norepinephrine and dopamine neurotransmitters. Option C: It activates 5-HT1D receptors on intracranial blood vessels, leading to vasoconstriction, and activates 5-HT1D receptors on sensory nerve endings of the trigeminal system, resulting in the inhibition of pro-inflammatory neuropeptide release. Option D: It inhibits serotonin reuptake, acts as a partial agonist of the 5-HT1B receptor, an agonist of 5-HT1A, and an antagonist of the 5-HT3, 5-HT1D, and 5-HT7 receptors. " C 643976 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC2=C(C=C1C)N(C3=NC(=O)NC(=O)C3=N2)C[C@@H]([C@@H]([C@@H](COP(=O)(O)O)O)O)O Question about this molecule: What is the mechanism of this molecule? Option A: It undergoes photoabsorption. Option B: It exhibits photoabsorption. Option C: It exhibits Magnetic Resonance Contrast Activity. Option D: It exhibits positron emitting activity. " B 813 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [K+] Question about this molecule: What is the mechanism of this molecule? Option A: It has an Osmotic Activity. Option B: It has an Ammonium Ion Binding Activity. Option C: It has Osmotic Activity. Option D: It works through Osmotic Activity. " C 947 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: N#N Question about this molecule: What is the mechanism of this molecule? Option A: It helps in removal of skin lesions through necrosis caused by freezing and thawing of cells. Option B: It stimulates the secretion of insulin granules from pancreatic islet beta cells by blocking ATP-sensitive potassium channels (KATP channels) and causing depolarization of the beta cells. Option C: It alters signal conduction in neurons by blocking fast voltage-gated sodium (Na+) channels in the neuronal cell membrane responsible for signal propagation. Option D: It lowers blood glucose by increasing the secretion of insulin from the pancreas and increasing the sensitivity of peripheral tissues to insulin. " A 12035 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)N[C@@H](CS)C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It has a renin inhibitor mechanism of action. Option B: It exhibits positron emitting activity. Option C: It has a positron emitting activity mechanism. Option D: It has a reduction activity mechanism. " D 135398744 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a phosphodiesterase 3 inhibitor. Option B: It acts as a cholinesterase inhibitor. Option C: It serves as a phosphodiesterase 5 inhibitor. Option D: It serves as a phosphodiesterase 3 inhibitor. " C 60825 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@H](O[C@H](S1)CO)N2C=CC(=NC2=O)N Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a nucleoside reverse transcriptase inhibitor. Option B: It is a nucleoside reverse transcriptase inhibitor and cytochrome P450 1A1 inhibitor. Option C: It acts as a non-nucleoside reverse transcriptase inhibitor. Option D: It inhibits nucleoside reverse transcriptase. " A 4634 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CC#CCOC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a cholinergic antagonist. Option B: It functions as a cholinergic muscarinic antagonist. Option C: It has a cholinergic antagonist mechanism of action. Option D: It serves as a cholinergic antagonist. " B 9782 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a prostaglandin receptor agonist. Option B: It acts as a corticosteroid hormone receptor agonist. Option C: It serves as a corticosteroid hormone receptor agonist. Option D: It agonizes corticosteroid hormone receptors. " B 59768 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(COC1=CC=C(C=C1)CCC(=O)OC)O Question about this molecule: What is the mechanism of this molecule? Option A: It serves as an adrenergic agonist. Option B: It serves as an adrenergic alpha-agonist. Option C: It serves as an adrenergic beta-antagonist. Option D: It acts as an adrenergic alpha-agonist and adrenergic beta-agonist. " C 4195 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC(=C(C=C1)OC)C(CNC(=O)CN)O Question about this molecule: What is the mechanism of this molecule? Option A: It acts as an adrenergic alpha-agonist and adrenergic beta-agonist. Option B: It serves as an adrenergic agonist. Option C: It serves as an adrenergic alpha-agonist. Option D: It serves as an adrenergic beta-antagonist. " C 11501341 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC1=CC=C(C=C1)/C=C/C2=CC=C(C=C2)OCCOCCOCC[18F] Question about this molecule: What is the mechanism of this molecule? Option A: It has ultrasound contrast activity. Option B: It exhibits positron emitting activity. Option C: It has a positron emitting activity mechanism. Option D: It exhibits Magnetic Resonance Contrast Activity. " C 5362124 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@H]2CCC3=CC=CC=C3N(C2=O)CC(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It is an Angiotensin-converting Enzyme Inhibitor. Option B: It works as an Angiotensin 2 Receptor Antagonist. Option C: It acts as an angiotensin 2 receptor antagonist. Option D: It works as an Angiotensin-converting Enzyme Inhibitor. " A 3105 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)C(=O)OC1=C(C=C(C=C1)C(CNC)O)OC(=O)C(C)(C)C Question about this molecule: What is the mechanism of this molecule? Option A: It serves as an adrenergic agonist. Option B: It serves as an adrenergic beta-antagonist. Option C: It serves as an adrenergic alpha-agonist. Option D: It acts as an adrenergic alpha-agonist and adrenergic beta-agonist. " A 60606 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)[C@H](C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3 Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a cytochrome P450 2D6 inhibitor. Option B: It is a proton pump inhibitor and cytochrome P450 2C19 inhibitor. Option C: It acts as a P2Y12 receptor antagonist and a cytochrome P450 2C8 inhibitor. Option D: It serves as a histone deacetylase inhibitor and cytochrome P450 2D6 inhibitor. " C 8314 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C)C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: Its mechanism of action is unknown, but it interferes with action potential conduction. Option B: It is a class Ia antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials. Option C: It has a broad-spectrum mechanism based on acidification of pathogens. Option D: It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent. " C 311 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)O)C(CC(=O)O)(C(=O)O)O Question about this molecule: What is the mechanism of this molecule? Option A: It has Acidifying Activity and Calcium Chelating Activity. Option B: It exhibits Iron Chelating Activity. Option C: It exhibits Phosphate Chelating Activity. Option D: It serves as a Lead Chelating Activity. " A 5757 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)O Question about this molecule: What is the mechanism of this molecule? Option A: It is an Androgen Receptor Agonist. Option B: It acts as an Androgen Receptor Antagonist. Option C: It works as an Estrogen Receptor Agonist. Option D: It is an Estrogen Receptor Agonist. " D 3219 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOCCN1C2=CC=CC=C2N=C1N3CCCN(CC3)C Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a Histamine Receptor Antagonist. Option B: It is a Histamine Receptor Antagonist. Option C: It serves as a Histamine H1 Receptor Antagonist. Option D: It is a Histamine H1 Receptor Antagonist. " D 25126798 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3 Question about this molecule: What is the mechanism of this molecule? Option A: It is a Protein Kinase Inhibitor. Option B: It acts as a Lipase Inhibitor. Option C: It works as a Protein Kinase Inhibitor. Option D: It is a Janus Kinase Inhibitor. " D 6446 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@]2([C@H](C[C@]4([C@H]3CC[C@]4(C)O)C)O)F Question about this molecule: What is the mechanism of this molecule? Option A: It is an Estrogen Receptor Agonist. Option B: It is an Androgen Receptor Agonist. Option C: It works as an Estrogen Receptor Agonist. Option D: It acts as an Androgen Receptor Antagonist. " B 6436 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CO)CCC5=CC(=O)C=C[C@@]53C)F)O Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a corticosteroid hormone receptor agonist. Option B: It serves as a prostaglandin receptor agonist. Option C: It serves as a corticosteroid hormone receptor agonist. Option D: It agonizes corticosteroid hormone receptors. " A 60172 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC(=C2C(=N1)N(C=N2)CCOCP(=O)(O)O)N Question about this molecule: What is the mechanism of this molecule? Option A: It is a nucleoside reverse transcriptase inhibitor and cytochrome P450 1A1 inhibitor. Option B: It acts as a nucleoside reverse transcriptase inhibitor. Option C: It inhibits nucleoside reverse transcriptase. Option D: It acts as a non-nucleoside reverse transcriptase inhibitor. " B 3652 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO Question about this molecule: What is the mechanism of this molecule? Option A: The exact mechanism of action is unknown, but it may be based on its ability to bind to and alter DNA. Option B: The precise mechanism of action is unknown, but it is postulated to block postsynaptic dopamine receptors. Option C: Its mechanism of action is unknown, but it interferes with action potential conduction. Option D: The exact mechanism of action is unknown, but it depresses the central nervous system. " A 51634 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCN1C[C@@H]([C@H]([C@@H]([C@H]1CO)O)O)O Question about this molecule: What is the mechanism of this molecule? Option A: It works as a Proteasome Inhibitor. Option B: It acts as a Lipase Inhibitor. Option C: It is a Glucosylceramide Synthase Inhibitor. Option D: It acts as a Neuraminidase Inhibitor. " C 60961 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N Question about this molecule: What is the mechanism of this molecule? Option A: It is a receptor agonist. Option B: It is a prostacyclin receptor agonist. Option C: It acts as a melatonin receptor agonist. Option D: It serves as a prostaglandin receptor agonist. " A 3825 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It works as a Cyclooxygenase Inhibitor. Option B: It acts as a Dipeptidase Inhibitor. Option C: It acts as a Lipase Inhibitor. Option D: It is a Cyclooxygenase Inhibitor. " D 60877 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@H](O[C@H](S1)CO)N2C=C(C(=NC2=O)N)F Question about this molecule: What is the mechanism of this molecule? Option A: It is a nucleoside reverse transcriptase inhibitor and cytochrome P450 1A1 inhibitor. Option B: It acts as a non-nucleoside reverse transcriptase inhibitor. Option C: It inhibits nucleoside reverse transcriptase. Option D: It acts as a nucleoside reverse transcriptase inhibitor. " D 5311 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO Question about this molecule: What is the mechanism of this molecule? Option A: It is a kinase inhibitor and P-glycoprotein inhibitor. Option B: It operates as a selective GABA reuptake inhibitor. Option C: It works as a serotonin uptake inhibitor. Option D: It acts as a histone deacetylase inhibitor. " D 5284371 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@H](C=C4)O Question about this molecule: What is the mechanism of this molecule? Option A: It is a Full Opioid Agonist. Option B: It acts as a Competitive Opioid Antagonist and Partial Opioid Agonist. Option C: It acts as an Opioid mu-Receptor Agonist. Option D: It acts as a Partial Opioid Agonist. " A 3385 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=O)NC(=O)N1)F Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Lipase Inhibitor. Option B: It functions as a Nucleic Acid Synthesis Inhibitor. Option C: It acts as a Nucleic Acid Synthesis Inhibitor. Option D: It serves as a Nucleoside Reverse Transcriptase Inhibitor. " C 5329 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=NO1)NS(=O)(=O)C2=CC=C(C=C2)N Question about this molecule: What is the mechanism of this molecule? Option A: It is a cytochrome P450 2C9 inhibitor. Option B: It acts as a P2Y12 receptor antagonist and a cytochrome P450 2C8 inhibitor. Option C: It serves as a cytochrome P450 2D6 inhibitor. Option D: It is a proton pump inhibitor and cytochrome P450 2C19 inhibitor. " A 2244 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)OC1=CC=CC=C1C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Lipase Inhibitor. Option B: It is a Cyclooxygenase Inhibitor. Option C: It works as a Cyclooxygenase Inhibitor. Option D: It acts as a Dipeptidase Inhibitor. " B 7028 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]([C@H](C1=CC=CC=C1)O)NC Question about this molecule: What is the mechanism of this molecule? Option A: It is an adrenergic alpha-agonist. Option B: It is an adrenergic beta-antagonist. Option C: It serves as an adrenergic beta-antagonist. Option D: It serves as an adrenergic alpha-agonist. " A 179344 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)O[C@H]1CC2=CC=CC=C2N(C3=CC=CC=C13)C(=O)N Question about this molecule: What is the mechanism of this molecule? Option A: It stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin. Option B: It inhibits repeated neuronal firing and stabilizes the inactivated state of voltage-gated sodium channels. Option C: It alters signal conduction in neurons by blocking fast voltage-gated sodium (Na+) channels in the neuronal cell membrane responsible for signal propagation. Option D: It can decrease intracellular calcium levels by inhibiting calcium influx through voltage-gated calcium channels. " B 72022 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC[C@@H](C(=O)O)N[C@@H](C)C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It acts as an angiotensin 2 receptor antagonist. Option B: It works as an Angiotensin 2 Receptor Antagonist. Option C: It works as an Angiotensin-converting Enzyme Inhibitor. Option D: It is an Angiotensin-converting Enzyme Inhibitor. " D 6337614 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C[C@@H]2CN(C(=O)C3=CC=CC(=C23)C1)[C@@H]4CN5CCC4CC5 Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits serotonin uptake. Option B: It is a serotonin 3 receptor antagonist. Option C: It acts as a Serotonin Uptake Inhibitor. Option D: It works as a serotonin uptake inhibitor. " B 5284632 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC[N+]2(C1)[C@@H]3CC[C@H]2CC(C3)OC(=O)C(C4=CC=CC=C4)(C5=CC=CC=C5)O Question about this molecule: What is the mechanism of this molecule? Option A: It is a Cholinergic Antagonist and Cholinergic Muscarinic Antagonist. Option B: It works as a Cholinergic Muscarinic Agonist. Option C: It works as a Cholinergic Agonist. Option D: It is a Cholinergic Muscarinic Antagonist. " D 6041 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC[C@@H](C1=CC(=CC=C1)O)O Question about this molecule: What is the mechanism of this molecule? Option A: It works as an Adrenergic alpha2-Agonist. Option B: It acts as an Adrenergic beta2-Agonist. Option C: It is an Adrenergic alpha2-Agonist. Option D: It acts as an Adrenergic alpha1-Agonist. " D 5509 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)C(=O)C2=CC=C(N2C)CC(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It has a 5-lipoxygenase inhibitor mechanism of action. Option B: It inhibits cyclooxygenase. Option C: It has a cyclooxygenase inhibitor mechanism of action. Option D: It serves as a cyclooxygenase inhibitor. " D 151075 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(=O)C2=CC=CC(=C2N)CC(=O)N Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a cyclooxygenase inhibitor. Option B: It inhibits cyclooxygenase. Option C: It has a cyclooxygenase inhibitor mechanism of action. Option D: It has a 5-lipoxygenase inhibitor mechanism of action. " A 11304743 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C1=C(N=C(N=C1N)C2=NN(C3=C2C=CC=N3)CC4=CC=CC=C4F)N)C(=O)OC Question about this molecule: What is the mechanism of this molecule? Option A: It exhibits Magnetic Resonance Contrast Activity. Option B: It has a Free Radical Scavenging Activity. Option C: It acts as a Smoothened Receptor Antagonist. Option D: It acts as a Guanylate Cyclase Stimulator. " D 3117 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)C(=S)SSC(=S)N(CC)CC Question about this molecule: What is the mechanism of this molecule? Option A: It serves as an Organic Cation Transporter 2 Inhibitor and Dihydrofolate Reductase Inhibitor. Option B: It is a 5-alpha Reductase Inhibitor. Option C: It serves as a 5-alpha Reductase Inhibitor. Option D: It acts as an Acetyl Aldehyde Dehydrogenase Inhibitor. " D 657298 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC1=CC(=O)NC(=S)N1 Question about this molecule: What is the mechanism of this molecule? Option A: It works as a Corticosteroid Hormone Receptor Agonist. Option B: It is a Thyroid Hormone Synthesis Inhibitor. Option C: It acts as a Progestational Hormone Receptor Antagonist. Option D: It functions as a Corticosteroid Hormone Receptor Agonist. " B 55245 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC#C[C@@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)O Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Smoothened Receptor Antagonist. Option B: It acts as a Progestational Hormone Receptor Antagonist. Option C: It serves as a Histamine Receptor Antagonist. Option D: It is a Histamine Receptor Antagonist. " B 54674461 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)NC1=C(N=C(N=C1N)C2=NN(C3=C2C=C(C=N3)F)CC4=CC=CC=C4F)N Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Guanylate Cyclase Stimulator. Option B: It acts as a Smoothened Receptor Antagonist. Option C: It exhibits Magnetic Resonance Contrast Activity. Option D: It has a Free Radical Scavenging Activity. " A 5311101 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)SCF)O)C)O)F)C)F Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a corticosteroid hormone receptor agonist. Option B: It serves as a prostaglandin receptor agonist. Option C: It serves as a corticosteroid hormone receptor agonist. Option D: It agonizes corticosteroid hormone receptors. " A 3059 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1C2=C(C=C(C=C2)F)F)C(=O)O)O Question about this molecule: What is the mechanism of this molecule? Option A: It has a 5-lipoxygenase inhibitor mechanism of action. Option B: It has a cyclooxygenase inhibitor mechanism of action. Option C: It serves as a cyclooxygenase inhibitor. Option D: It inhibits cyclooxygenase. " C 24414 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]S(=O)(=O)[O-].[Ba+2] Question about this molecule: What is the mechanism of this molecule? Option A: It has a X-Ray Contrast Activity. Option B: It functions as a X-Ray Contrast Activity. Option C: It is an X-Ray Contrast Activity. Option D: It exhibits x-ray contrast activity. " D 1018 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=NC(=C1)C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It depletes the neurotransmitter of painful impulses known as substance P from the sensory nerve terminals. Option B: It is a class Ia antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials. Option C: It acts by preventing transmission of impulses along nerve fibers and at nerve endings. Option D: It works by binding to zinc finger proteins (ZFPs) in a way that changes their structures and disrupts zinc binding, inhibiting function. " D 2162 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN Question about this molecule: What is the mechanism of this molecule? Option A: It functions as a calcium channel antagonist and cytochrome P450 3A inhibitor. Option B: It serves as a histone deacetylase inhibitor and cytochrome P450 2D6 inhibitor. Option C: It is a proton pump inhibitor and cytochrome P450 2C19 inhibitor. Option D: It acts as a P2Y12 receptor antagonist and a cytochrome P450 2C8 inhibitor. " A 3305 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(O)(P(=O)(O)O)P(=O)(O)O Question about this molecule: What is the mechanism of this molecule? Option A: It binds strongly to hydroxyapatite crystals in the bone matrix, preferentially at the sites of increased bone turnover, and inhibits the formation and dissolution of the crystals. Option B: It activates 5-HT1D receptors on intracranial blood vessels, leading to vasoconstriction, and activates 5-HT1D receptors on sensory nerve endings of the trigeminal system, resulting in the inhibition of pro-inflammatory neuropeptide release. Option C: It inhibits urate crystal deposition, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Option D: It has a high affinity for 5-HTA1 and 5-HTA2 receptors, displaying agonist activity on 5-HTA1 and antagonist on 5-HTA2, resulting in lowering of serotonin in the brain as well as an effect on increasing norepinephrine and dopamine neurotransmitters. " A 54585 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C(=O)NCCC(=O)O)N=NC2=CC(=C(C=C2)O)C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits urate crystal deposition, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Option B: It acts as a non-competitive inhibitor for an enzyme in mitochondria called cytochrome c oxidase, halting cellular respiration. Option C: It halts weed growth, eventually killing the weed or causing it to die due to its incapability to compete with surrounding vegetation. Option D: It delivers mesalazine to the large intestine to act directly on ulcerative colitis. " D 4171 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(COC1=CC=C(C=C1)CCOC)O Question about this molecule: What is the mechanism of this molecule? Option A: It works as an Adrenergic alpha2-Agonist. Option B: It acts as an Adrenergic alpha1-Agonist. Option C: It functions as an Adrenergic beta-Antagonist. Option D: It acts as an Adrenergic alpha-Antagonist. " C 9865442 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)OCCl)O)CCC4=CC(=O)C=C[C@]34C)O Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a corticosteroid hormone receptor agonist. Option B: It serves as a prostaglandin receptor agonist. Option C: It agonizes corticosteroid hormone receptors. Option D: It acts as a corticosteroid hormone receptor agonist. " D 5095 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN(CCC)CCC1=C2CC(=O)NC2=CC=C1 Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a dopamine agonist. Option B: It acts as a dopamine agonist. Option C: It functions as a Dopamine Agonist. Option D: It acts as a dopamine D2 antagonist. " A 4771 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(CC1=CC=CC=C1)N Question about this molecule: What is the mechanism of this molecule? Option A: It acts on brain catecholaminergic neurons and inhibits dopamine uptake. Option B: It inhibits catecholamine synthesis. Option C: It blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins. Option D: It suppresses hunger signals and appetite by increasing catecholamine levels. " D 3676 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CC(=O)NC1=C(C=CC=C1C)C Question about this molecule: What is the mechanism of this molecule? Option A: It alters signal conduction in neurons by blocking fast voltage-gated sodium (Na+) channels in the neuronal cell membrane responsible for signal propagation. Option B: It inhibits repeated neuronal firing and stabilizes the inactivated state of voltage-gated sodium channels. Option C: It stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin. Option D: It can decrease intracellular calcium levels by inhibiting calcium influx through voltage-gated calcium channels. " A 5754 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a prostaglandin receptor agonist. Option B: It serves as a corticosteroid hormone receptor agonist. Option C: It acts as a corticosteroid hormone receptor agonist. Option D: It agonizes corticosteroid hormone receptors. " C 39468 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)NC[C@@H](COC1=CC=CC2=C1CCCC2=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It is an adrenergic alpha-agonist. Option B: It is an adrenergic beta-antagonist. Option C: It serves as an adrenergic beta-antagonist. Option D: It serves as an adrenergic alpha-agonist. " B 29936 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Fe+3] Question about this molecule: What is the mechanism of this molecule? Option A: It has Acidifying Activity and Calcium Chelating Activity. Option B: It exhibits Phosphate Chelating Activity. Option C: It serves as a Lead Chelating Activity. Option D: It exhibits Iron Chelating Activity. " B 1727 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CN=CC=C1N Question about this molecule: What is the mechanism of this molecule? Option A: It opens Potassium Channels. Option B: It acts as a Potassium Channel Antagonist. Option C: It inhibits DNA Polymerase. Option D: It functions as a DNA Polymerase Inhibitor. " B 4499 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC Question about this molecule: What is the mechanism of this molecule? Option A: It has a sodium channel inhibition mechanism. Option B: It functions as a calcium channel antagonist and cytochrome P450 3A inhibitor. Option C: It functions as a calcium channel antagonist. Option D: It acts as a calcium channel antagonist. " D 20469 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)Cl)C Question about this molecule: What is the mechanism of this molecule? Option A: It agonizes corticosteroid hormone receptors. Option B: It acts as a corticosteroid hormone receptor agonist. Option C: It serves as a prostaglandin receptor agonist. Option D: It serves as a corticosteroid hormone receptor agonist. " B 3961 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl Question about this molecule: What is the mechanism of this molecule? Option A: It acts as an endothelin receptor antagonist. Option B: It is an angiotensin 2 type 1 receptor antagonist. Option C: It functions as an angiotensin 2 receptor antagonist. Option D: It acts as an angiotensin 2 receptor antagonist. " D 9835049 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C[C@H](N2C[C@@H]1N(C2=O)OS(=O)(=O)O)C(=O)N Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits protein synthesis. Option B: It inhibits kinases. Option C: It inhibits protein kinase. Option D: It inhibits beta Lactamase. " D 2375 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CS(=O)(=O)C1=CC=C(C=C1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O Question about this molecule: What is the mechanism of this molecule? Option A: It is an Androgen Receptor Agonist. Option B: It works as an Estrogen Receptor Agonist. Option C: It is an Estrogen Receptor Agonist. Option D: It acts as an Androgen Receptor Antagonist. " D 4917 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl Question about this molecule: What is the mechanism of this molecule? Option A: It depresses the chemoreceptor trigger zone and blocks D2 dopamine receptors in the brain. Option B: It is a Histamine H1 Receptor Antagonist. Option C: It serves as a Histamine Receptor Antagonist. Option D: It serves as a Histamine H1 Receptor Antagonist. " A 3690 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(P(=O)(OC1)NCCCl)CCCl Question about this molecule: What is the mechanism of this molecule? Option A: It has an alkylating activity mechanism of action. Option B: It exhibits Methylating Activity. Option C: It has alkylating activity. Option D: It has an alkylating activity. " C 71496458 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC Question about this molecule: What is the mechanism of this molecule? Option A: It is a Cytochrome P450 2D6 Inhibitor and Cytochrome P450 3A4 Inducer. Option B: It inhibits Cytochrome P450 3A4, Cytochrome P450 2C19, and Cytochrome P450 2C9. Option C: It inhibits Kinase, Cytochrome P450 3A, Cytochrome P450 3A4, Cytochrome P450 1A2, and Breast Cancer Resistance Protein. Option D: It inhibits Cytochrome P450 17A1, Cytochrome P450 2D6, and Cytochrome P450 2C8. " C 25419 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(P(=O)(O)O)(P(=O)(O)O)(Cl)Cl Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits urate crystal deposition, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Option B: It acts as a non-competitive inhibitor for an enzyme in mitochondria called cytochrome c oxidase, halting cellular respiration. Option C: The exact mechanism of action is not known, but it can be metabolized to a cytotoxic analog of ATP (AppCCl2p). Option D: It halts weed growth, eventually killing the weed or causing it to die due to its incapability to compete with surrounding vegetation. " C 189562 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC2=C(C=CC(=C2)F)O[C@H]1[C@@H](CNC[C@H]([C@@H]3CCC4=C(O3)C=CC(=C4)F)O)O Question about this molecule: What is the mechanism of this molecule? Option A: It serves as an adrenergic beta-antagonist. Option B: It is an adrenergic alpha-agonist. Option C: It is an adrenergic beta-antagonist. Option D: It serves as an adrenergic alpha-agonist. " C 2771 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Serotonin Uptake Inhibitor. Option B: It serves as a Serotonin Uptake Inhibitor. Option C: It inhibits serotonin uptake. Option D: It works as a serotonin uptake inhibitor. " D 5288826 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](C=C4)O Question about this molecule: What is the mechanism of this molecule? Option A: It is a Full Opioid Agonist. Option B: It acts as a Competitive Opioid Antagonist and Partial Opioid Agonist. Option C: It acts as a Partial Opioid Agonist. Option D: It acts as an Opioid mu-Receptor Agonist. " A 3333 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C Question about this molecule: What is the mechanism of this molecule? Option A: It functions as a calcium channel antagonist and cytochrome P450 3A inhibitor. Option B: It functions as a calcium channel antagonist. Option C: It acts as a calcium channel antagonist. Option D: It has a sodium channel inhibition mechanism. " B 54454 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C)(C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits hydroxymethylglutaryl-CoA reductase. Option B: It is a 5-alpha Reductase Inhibitor. Option C: It acts as a Hydroxymethylglutaryl-CoA Reductase Inhibitor. Option D: It serves as a 5-alpha Reductase Inhibitor. " A 104741 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)[C@@H](CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F Question about this molecule: What is the mechanism of this molecule? Option A: It has a gonadotropin releasing hormone receptor antagonist mechanism of action. Option B: It functions as an estrogen receptor antagonist and selective estrogen receptor modulator. Option C: It acts as a GABA A receptor positive modulator. Option D: It acts as a selective estrogen receptor modulator. " B 5253 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O Question about this molecule: What is the mechanism of this molecule? Option A: It serves as an adrenergic beta-antagonist. Option B: It is an adrenergic alpha-agonist. Option C: It serves as an adrenergic alpha-agonist. Option D: It is an adrenergic beta-antagonist. " D 9926791 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1CCN(C[C@@H]1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits protein synthesis. Option B: It inhibits protein kinase. Option C: It inhibits kinases. Option D: It inhibits Janus kinase. " D 5484727 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2[C@H]3CCCC[C@@H]3C[C@H]2C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It works as an Angiotensin 2 Receptor Antagonist. Option B: It inhibits angiotensin-converting enzyme. Option C: It has an angiotensin-converting enzyme inhibitor mechanism of action. Option D: It works as an Angiotensin-converting Enzyme Inhibitor. " B 3339 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl Question about this molecule: What is the mechanism of this molecule? Option A: It activates peroxisome proliferator-activated receptor alpha. Option B: It serves as a cytochrome P450 3A4 inhibitor, P-glycoprotein inhibitor, and breast cancer resistance protein inhibitor. Option C: It serves as a neurokinin 1 antagonist, cytochrome P450 2D6 inhibitor, breast cancer resistance protein inhibitor, and P-glycoprotein inhibitor. Option D: It is a Peroxisome Proliferator-activated Receptor alpha Agonist and Peroxisome Proliferator-activated Receptor gamma Agonist. " A 27854 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Mn+2] Question about this molecule: What is the mechanism of this molecule? Option A: It has ultrasound contrast activity. Option B: It has a positron emitting activity mechanism. Option C: It exhibits positron emitting activity. Option D: It exhibits Magnetic Resonance Contrast Activity. " D 2708 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl Question about this molecule: What is the mechanism of this molecule? Option A: It has an alkylating activity mechanism of action. Option B: It exhibits Methylating Activity. Option C: It has alkylating activity. Option D: It has an alkylating activity. " C 49806720 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC1=CC2=C(C=C1N3CCC(CC3)N4CCOCC4)C(C5=C(C2=O)C6=C(N5)C=C(C=C6)C#N)(C)C Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits protein synthesis. Option B: It inhibits protein kinase. Option C: It inhibits kinases. Option D: It inhibits Janus kinase. " C 124087 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4 Question about this molecule: What is the mechanism of this molecule? Option A: It is a Histamine Receptor Antagonist. Option B: It serves as a Histamine H1 Receptor Antagonist. Option C: It is a Histamine H1 Receptor Antagonist. Option D: It serves as a Histamine Receptor Antagonist. " C 444 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits the uptake of dopamine and norepinephrine. Option B: It inhibits Dopamine Uptake, Norepinephrine Uptake, and Serotonin Uptake. Option C: It is a Norepinephrine Uptake Inhibitor and Serotonin Uptake Inhibitor. Option D: It serves as a Serotonin Uptake Inhibitor. " A 9878 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@]2([C@@]4(C1=CC(=O)C=C4)C)F)O)C)(C(=O)C)O Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a corticosteroid hormone receptor agonist. Option B: It agonizes corticosteroid hormone receptors. Option C: It serves as a corticosteroid hormone receptor agonist. Option D: It serves as a prostaglandin receptor agonist. " A 151171 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NC2=C(N1)CCN(C3=CC=CC=C32)C(=O)C4=CC=C(C=C4)NC(=O)C5=CC=CC=C5C6=CC=CC=C6 Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Serotonin 2c Receptor Agonist and Cytochrome P450 2D6 Inhibitor. Option B: It acts as a Vasopressin Receptor Antagonist and Cytochrome P450 3A Inhibitor. Option C: It is a Serotonin Uptake Inhibitor and Cytochrome P450 2D6 Inhibitor. Option D: It is a P2Y12 Receptor Antagonist, Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor. " B 5462501 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](C(=O)N1CCC[C@H]1C(=O)O)N[C@@H](CCC2=CC=CC=C2)C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It is an Angiotensin-converting Enzyme Inhibitor. Option B: It works as an Angiotensin-converting Enzyme Inhibitor. Option C: It works as an Angiotensin 2 Receptor Antagonist. Option D: It acts as an angiotensin 2 receptor antagonist. " A 3672 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CC1=CC=C(C=C1)C(C)C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It is a Cyclooxygenase Inhibitor. Option B: It acts as a Dipeptidase Inhibitor. Option C: It acts as a Lipase Inhibitor. Option D: It works as a Cyclooxygenase Inhibitor. " A 5578 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Chloride Channel Activation Potentiator, Cytochrome P450 2C9 Inhibitor, P-Glycoprotein Inhibitor, and Cytochrome P450 3A Inhibitor. Option B: It acts as a Cytochrome P450 3A4 Inhibitor, Organic Cation Transporter 2 Inhibitor, and P-Glycoprotein Inhibitor. Option C: It acts as a Cytochrome P450 3A Inhibitor, P-Glycoprotein Inhibitor, Cytochrome P450 2D6 Inhibitor, and Organic Cation Transporter 2 Inhibitor. Option D: It acts as a Dihydrofolate Reductase Inhibitor, Cytochrome P450 2C8 Inhibitor, and Organic Cation Transporter 2 Inhibitor. " D 222786 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2C(=O)C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C Question about this molecule: What is the mechanism of this molecule? Option A: It agonizes corticosteroid hormone receptors. Option B: It serves as a corticosteroid hormone receptor agonist. Option C: It acts as a corticosteroid hormone receptor agonist. Option D: It serves as a prostaglandin receptor agonist. " C 6058 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CS)N Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a Histamine H1 Receptor Antagonist. Option B: It acts as a Cystine Disulfide Reduction. Option C: It is a Histamine Receptor Antagonist. Option D: It serves as a Histamine Receptor Antagonist. " B 2764 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It is a Serotonin Uptake Inhibitor and Cytochrome P450 2D6 Inhibitor. Option B: It acts as a Cytochrome P450 1A2 Inhibitor. Option C: It is a Kinase Inhibitor and Cytochrome P450 3A Inhibitor. Option D: It is a Protein Kinase Inhibitor and Cytochrome P450 3A4 Inhibitor. " B 3365 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O Question about this molecule: What is the mechanism of this molecule? Option A: It is a Protein Kinase Inhibitor, Cytochrome P450 3A4 Inhibitor, Cytochrome P450 2D6 Inhibitor, and mTOR Inhibitor. Option B: It acts as a Tyrosine Kinase Inhibitor, Cytochrome P450 3A Inhibitor, and Cytochrome P450 2C9 Inhibitor. Option C: It acts as a Cytochrome P450 2C19 Inhibitor, Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C9 Inhibitor. Option D: It is a Protein Kinase Inhibitor, Cytochrome P450 3A4 Inhibitor, Cytochrome P450 2D6 Inhibitor, and Cytochrome P450 2C8 Inhibitor. " C 3386 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits Dopamine Uptake, Norepinephrine Uptake, and Serotonin Uptake. Option B: It serves as a Serotonin Uptake Inhibitor. Option C: It is a Norepinephrine Uptake Inhibitor and Serotonin Uptake Inhibitor. Option D: It acts as a Serotonin Uptake Inhibitor. " D 56959 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CC(COC3=CC=CC=C3OC)O Question about this molecule: What is the mechanism of this molecule? Option A: It is a Protein Kinase Inhibitor, Cytochrome P450 3A4 Inhibitor, Cytochrome P450 2D6 Inhibitor, and Cytochrome P450 2C8 Inhibitor. Option B: It acts as a Tyrosine Kinase Inhibitor, Cytochrome P450 3A Inhibitor, and Cytochrome P450 2C9 Inhibitor. Option C: It acts as a Cytochrome P450 3A Inhibitor, P-Glycoprotein Inhibitor, Cytochrome P450 2D6 Inhibitor, and Organic Cation Transporter 2 Inhibitor. Option D: It acts as a Cytochrome P450 2C19 Inhibitor, Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C9 Inhibitor. " C 441335 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CCl)O)C)O)Cl)C Question about this molecule: What is the mechanism of this molecule? Option A: It agonizes corticosteroid hormone receptors. Option B: It serves as a corticosteroid hormone receptor agonist. Option C: It acts as a corticosteroid hormone receptor agonist. Option D: It serves as a prostaglandin receptor agonist. " C 5311051 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CCl)O)C)O)F)C Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a prostaglandin receptor agonist. Option B: It acts as a corticosteroid hormone receptor agonist. Option C: It serves as a corticosteroid hormone receptor agonist. Option D: It agonizes corticosteroid hormone receptors. " B 5388962 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It works as an Angiotensin 2 Receptor Antagonist. Option B: It inhibits angiotensin-converting enzyme. Option C: It works as an Angiotensin-converting Enzyme Inhibitor. Option D: It has an angiotensin-converting enzyme inhibitor mechanism of action. " B 123630 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@]1([C@@H](N2[C@H](S1(=O)=O)CC2=O)C(=O)O)CN3C=CN=N3 Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits protein synthesis. Option B: It inhibits protein kinase. Option C: It inhibits kinases. Option D: It inhibits beta Lactamase. " D 10548 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=O)(OCC)SCC[N+](C)(C)C Question about this molecule: What is the mechanism of this molecule? Option A: It exhibits Cholinesterase Inhibitor activity. Option B: It functions as a Cholinesterase Inhibitor. Option C: It functions as a Cholinesterase Reactivator. Option D: It inhibits Cholinesterase. " D 60700 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O Question about this molecule: What is the mechanism of this molecule? Option A: It functions as a DNA Polymerase Inhibitor. Option B: It inhibits topoisomerase. Option C: It inhibits DNA Polymerase. Option D: It inhibits DNA-dependent RNA polymerase. " B 135398654 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]([C@@H]([C@H]1CNC2=C(N1)C(=O)NC(=N2)N)O)O Question about this molecule: What is the mechanism of this molecule? Option A: It antagonizes neurokinin 1 receptors, cytochrome P450 3A4, P-glycoprotein, and breast cancer resistance protein. Option B: It serves as a cytochrome P450 3A4 inhibitor, P-glycoprotein inhibitor, and breast cancer resistance protein inhibitor. Option C: It serves as a neurokinin 1 antagonist, cytochrome P450 2D6 inhibitor, breast cancer resistance protein inhibitor, and P-glycoprotein inhibitor. Option D: It activates Phenylalanine Hydroxylase, and inhibits Breast Cancer Resistance Protein and P-Glycoprotein. " D 5565 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CNCCNCCN)N Question about this molecule: What is the mechanism of this molecule? Option A: It has metal chelating activity. Option B: It has lead chelating activity and calcium chelating activity. Option C: It has Acidifying Activity and Calcium Chelating Activity. Option D: It has alkylating activity. " A 5280980 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@@H]2N(C1=O)[C@H](/C(=C/CO)/O2)C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits beta Lactamase. Option B: It inhibits kinases. Option C: It inhibits protein synthesis. Option D: It inhibits protein kinase. " A 60613 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CN(C(=O)N=C1N)C[C@@H](CO)OCP(=O)(O)O Question about this molecule: What is the mechanism of this molecule? Option A: It functions as a DNA Polymerase Inhibitor. Option B: It inhibits topoisomerase. Option C: It inhibits DNA Polymerase. Option D: It inhibits DNA-dependent RNA polymerase. " C 135398740 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC2=C(N1COC(CO)CO)N=C(NC2=O)N Question about this molecule: What is the mechanism of this molecule? Option A: It is a Topoisomerase Inhibitor. Option B: It functions as a DNA Polymerase Inhibitor. Option C: It acts as a DNA Polymerase Inhibitor. Option D: It works as a Proteasome Inhibitor. " B 54892 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2CC3=CC=CC=C3C[C@H]2C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It is an Angiotensin-converting Enzyme Inhibitor. Option B: It acts as an angiotensin 2 receptor antagonist. Option C: It works as an Angiotensin-converting Enzyme Inhibitor. Option D: It works as an Angiotensin 2 Receptor Antagonist. " C 449381 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(CC)O[C@@H]1C=C(C[C@@H]([C@H]1NC(=O)C)N)C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Neuraminidase Inhibitor. Option B: It acts as a Proton Pump Inhibitor. Option C: It functions as a Proton Pump Inhibitor. Option D: It acts as a Lipase Inhibitor. " A 54680692 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Proteasome Inhibitor. Option B: It acts as a Proton Pump Inhibitor. Option C: It works as a Proteasome Inhibitor. Option D: It acts as a Vitamin K Inhibitor. " D 2564 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCOC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2 Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a Histamine H1 Receptor Antagonist. Option B: It serves as a Histamine Receptor Antagonist. Option C: It is a Histamine H1 Receptor Antagonist. Option D: It is a Histamine Receptor Antagonist. " A 131536 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CN(C[C@H]([C@H](CC1=CC=CC=C1)NC(=O)O[C@H]2CCOC2)OP(=O)(O)O)S(=O)(=O)C3=CC=C(C=C3)N Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Proteasome Inhibitor. Option B: It works as a Proteasome Inhibitor. Option C: It functions as a HIV Protease Inhibitor. Option D: It acts as a Proton Pump Inhibitor. " C 86137 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C1(C(=O)NC(=N1)C2=C(C=C(C=N2)COC)C(=O)O)C Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits protein synthesis. Option B: It prevents plants from producing an essential enzyme, acetolactate synthase (ALS). Option C: It inhibits protein kinase. Option D: It selectively and reversibly inhibits MAO-A. " B 65492 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](C(=O)NC1=C(C(=C(C(=C1I)C(=O)NC(CO)CO)I)C(=O)NC(CO)CO)I)O Question about this molecule: What is the mechanism of this molecule? Option A: It has a X-Ray Contrast Activity. Option B: It functions as a X-Ray Contrast Activity. Option C: It is an X-Ray Contrast Activity. Option D: It exhibits Magnetic Resonance Contrast Activity. " B 3715 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a cyclooxygenase inhibitor. Option B: It has a 5-lipoxygenase inhibitor mechanism of action. Option C: It inhibits cyclooxygenase. Option D: It has a cyclooxygenase inhibitor mechanism of action. " A 4409 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)CCC1=CC2=C(C=C1)C=C(C=C2)OC Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Lipase Inhibitor. Option B: It works as a Cyclooxygenase Inhibitor. Option C: It is a Cyclooxygenase Inhibitor. Option D: It acts as a Dipeptidase Inhibitor. " C 5526 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC(CCC1CN)C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent. Option B: It is a class Ia antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials. Option C: It mimics epilepsy by blocking the inhibitory action of GABA receptors. Option D: The hypotensive effects are not necessarily due to its diuretic activity. " A 60750 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CN(C(=O)N=C1N)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Nucleic Acid Synthesis Inhibitor. Option B: It serves as a Nucleoside Reverse Transcriptase Inhibitor. Option C: It functions as a Nucleic Acid Synthesis Inhibitor. Option D: It acts as a Lipase Inhibitor. " C 119182 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC2=C(N=C(N=C2N1[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)F)Cl)N Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits nucleic acid synthesis. Option B: It inhibits melanin synthesis. Option C: It inhibits protein synthesis. Option D: It inhibits protein kinase. " A 3080 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(CS)S)O Question about this molecule: What is the mechanism of this molecule? Option A: It has alkylating activity. Option B: It has lead chelating activity and calcium chelating activity. Option C: It has Acidifying Activity and Calcium Chelating Activity. Option D: It has metal chelating activity. " D 31703 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O Question about this molecule: What is the mechanism of this molecule? Option A: It functions as a DNA Polymerase Inhibitor. Option B: It inhibits topoisomerase. Option C: It inhibits DNA Polymerase. Option D: It inhibits DNA-dependent RNA polymerase. " B 446220 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1[C@H]2CC[C@@H]1[C@H]([C@H](C2)OC(=O)C3=CC=CC=C3)C(=O)OC Question about this molecule: What is the mechanism of this molecule? Option A: It blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins. Option B: It acts on brain catecholaminergic neurons and inhibits dopamine uptake. Option C: The precise mechanism of action is unknown, but it is postulated to block postsynaptic dopamine receptors. Option D: Its exact mechanism of action is unclear, but it inhibits the reuptake of dopamine by binding to the dopamine reuptake pump, leading to an increase in extracellular dopamine. " B 1978 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(=O)NC1=CC(=C(C=C1)OCC(CNC(C)C)O)C(=O)C Question about this molecule: What is the mechanism of this molecule? Option A: It serves as an adrenergic alpha-agonist. Option B: It is an adrenergic beta-antagonist. Option C: It serves as an adrenergic beta-antagonist. Option D: It is an adrenergic alpha-agonist. " B 3883 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCC(F)(F)F Question about this molecule: What is the mechanism of this molecule? Option A: It has a positron emitting activity mechanism. Option B: It inhibits proton pump. Option C: It exhibits positron emitting activity. Option D: It exhibits Magnetic Resonance Contrast Activity. " B 5463984 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC2=CC=CC=C2N(C(=O)[C@H]1N[C@@H](CCC3=CC=CC=C3)C(=O)O)CC(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It works as an Angiotensin-converting Enzyme Inhibitor. Option B: It works as an Angiotensin 2 Receptor Antagonist. Option C: It has an angiotensin-converting enzyme inhibitor mechanism of action. Option D: It inhibits angiotensin-converting enzyme. " D 5324346 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCCC/C(=N\\OCCN)/C1=CC=C(C=C1)C(F)(F)F Question about this molecule: What is the mechanism of this molecule? Option A: It works as a serotonin uptake inhibitor. Option B: It acts as a Serotonin Uptake Inhibitor. Option C: It serves as a Serotonin Uptake Inhibitor. Option D: It inhibits serotonin uptake. " D 107994 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](C(=O)N1CC2=CC=CC=C2C[C@H]1C(=O)O)N[C@@H](CCC3=CC=CC=C3)C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits angiotensin-converting enzyme. Option B: It has an angiotensin-converting enzyme inhibitor mechanism of action. Option C: It works as an Angiotensin-converting Enzyme Inhibitor. Option D: It works as an Angiotensin 2 Receptor Antagonist. " A 54687 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@H](C)C(=O)O[C@H]1C[C@@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@H](C[C@H](CC(=O)O)O)O)O Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a 5-alpha Reductase Inhibitor. Option B: It is a 5-alpha Reductase Inhibitor. Option C: It inhibits hydroxymethylglutaryl-CoA reductase. Option D: It acts as a Hydroxymethylglutaryl-CoA Reductase Inhibitor. " C 3341 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CNCC(C2=CC(=C(C(=C21)Cl)O)O)C3=CC=C(C=C3)O Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a dopamine agonist. Option B: It acts as a dopamine agonist. Option C: It acts as a dopamine D2 antagonist. Option D: It functions as a Dopamine Agonist. " B 54746 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@H]2[C@@H](CC3=CNC4=CC=CC2=C34)N(C1)CC=C Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits repeated neuronal firing and stabilizes the inactivated state of voltage-gated sodium channels. Option B: It stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin. Option C: It can decrease intracellular calcium levels by inhibiting calcium influx through voltage-gated calcium channels. Option D: It alters signal conduction in neurons by blocking fast voltage-gated sodium (Na+) channels in the neuronal cell membrane responsible for signal propagation. " C 65016 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CN(C[C@H]([C@H](CC1=CC=CC=C1)NC(=O)O[C@H]2CCOC2)O)S(=O)(=O)C3=CC=C(C=C3)N Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Tyrosine Kinase Inhibitor, Cytochrome P450 3A Inhibitor, and Cytochrome P450 2C9 Inhibitor. Option B: It is a Protein Kinase Inhibitor, Cytochrome P450 3A4 Inhibitor, Cytochrome P450 2D6 Inhibitor, and Cytochrome P450 2C8 Inhibitor. Option C: It acts as a Cytochrome P450 3A Inhibitor, P-Glycoprotein Inhibitor, Cytochrome P450 2D6 Inhibitor, and Organic Cation Transporter 2 Inhibitor. Option D: It works as a HIV Protease Inhibitor, Cytochrome P450 3A4 Inhibitor, Cytochrome P450 3A4 Inducer, and P-Glycoprotein Inducer. " D 5329102 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\\2/C3=C(C=CC(=C3)F)NC2=O)C Question about this molecule: What is the mechanism of this molecule? Option A: It works as a Proteasome Inhibitor. Option B: It is a Protein Kinase Inhibitor. Option C: It works as a Protein Kinase Inhibitor. Option D: It acts as a Lipase Inhibitor. " C 25183872 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: B([C@H](CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O Question about this molecule: What is the mechanism of this molecule? Option A: It works as a Proteasome Inhibitor. Option B: It functions as a Proton Pump Inhibitor. Option C: It acts as a Proton Pump Inhibitor. Option D: It acts as a Proteasome Inhibitor. " A 3308 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC1=C2C(=CC=C1)C3=C(N2)C(OCC3)(CC)CC(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It works as a Cyclooxygenase Inhibitor. Option B: It is a Cyclooxygenase Inhibitor. Option C: It acts as a Dipeptidase Inhibitor. Option D: It acts as a Lipase Inhibitor. " A 4659569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)C(=O)C2=CC(=C(C(=C2)O)O)[N+](=O)[O-] Question about this molecule: What is the mechanism of this molecule? Option A: It works as a Catechol O-Methyltransferase Inhibitor. Option B: It acts as a Neuraminidase Inhibitor. Option C: It acts as a Dipeptidase Inhibitor. Option D: It acts as a Catechol O-Methyltransferase Inhibitor. " A 6912 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@H](C([C@H](CO)O)O)O)O Question about this molecule: What is the mechanism of this molecule? Option A: It binds strongly to hydroxyapatite crystals in the bone matrix, preferentially at the sites of increased bone turnover, and inhibits the formation and dissolution of the crystals. Option B: It inhibits urate crystal deposition, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Option C: It activates 5-HT1D receptors on intracranial blood vessels, leading to vasoconstriction, and activates 5-HT1D receptors on sensory nerve endings of the trigeminal system, resulting in the inhibition of pro-inflammatory neuropeptide release. Option D: It inhibits the growth of microorganisms present in plaque and saliva after accumulating intracellularly into the microorganism. " D 1993 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C[N+](C)(C)C)OC(=O)C Question about this molecule: What is the mechanism of this molecule? Option A: It works as a Cholinergic Muscarinic Agonist. Option B: It is a Cholinergic Muscarinic Antagonist. Option C: It works as a Cholinergic Agonist. Option D: It is a Cholinergic Antagonist and Cholinergic Muscarinic Antagonist. " C 5311067 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@H]1C(=O)CO)C)O)F)C Question about this molecule: What is the mechanism of this molecule? Option A: It is a Gonadotropin Releasing Hormone Receptor Agonist. Option B: It acts as a Progestational Hormone Receptor Antagonist. Option C: It works as a Corticosteroid Hormone Receptor Agonist. Option D: It functions as a Corticosteroid Hormone Receptor Agonist. " C 213039 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CN(C[C@H]([C@H](CC1=CC=CC=C1)NC(=O)O[C@H]2CO[C@@H]3[C@H]2CCO3)O)S(=O)(=O)C4=CC=C(C=C4)N Question about this molecule: What is the mechanism of this molecule? Option A: It works as a HIV Protease Inhibitor, Cytochrome P450 3A Inhibitor, and Cytochrome P450 2D6 Inhibitor. Option B: It is a Protein Kinase Inhibitor, Cytochrome P450 3A4 Inhibitor, Cytochrome P450 2D6 Inhibitor, and Cytochrome P450 2C8 Inhibitor. Option C: It is a Protein Kinase Inhibitor, Cytochrome P450 3A4 Inhibitor, Cytochrome P450 2D6 Inhibitor, and mTOR Inhibitor. Option D: It acts as a Tyrosine Kinase Inhibitor, Cytochrome P450 3A Inhibitor, and Cytochrome P450 2C9 Inhibitor. " A 6251 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O Question about this molecule: What is the mechanism of this molecule? Option A: It has Osmotic Activity. Option B: It has an Ammonium Ion Binding Activity. Option C: It works through Osmotic Activity. Option D: It has an Osmotic Activity. " C 2370 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C[N+](C)(C)C)OC(=O)N Question about this molecule: What is the mechanism of this molecule? Option A: It works as a Cholinergic Agonist. Option B: It works as a Cholinergic Muscarinic Agonist. Option C: It is a Cholinergic Antagonist and Cholinergic Muscarinic Antagonist. Option D: It is a Cholinergic Muscarinic Antagonist. " B 6215 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CO)C[C@@H](C5=CC(=O)C=C[C@@]53C)F)F)O Question about this molecule: What is the mechanism of this molecule? Option A: It is a Gonadotropin Releasing Hormone Receptor Agonist. Option B: It works as a Corticosteroid Hormone Receptor Agonist. Option C: It functions as a Corticosteroid Hormone Receptor Agonist. Option D: It acts as a Progestational Hormone Receptor Antagonist. " B 154234 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(CC)[C@@H]([C@H]1[C@@H](C[C@@H]([C@H]1O)C(=O)O)N=C(N)N)NC(=O)C Question about this molecule: What is the mechanism of this molecule? Option A: It serves as an HIV integrase inhibitor and cytochrome P450 2C9 inducer. Option B: It works as an influenza virus neuraminidase inhibitor. Option C: It serves as a histone deacetylase inhibitor and cytochrome P450 2D6 inhibitor. Option D: It is an alpha glucosidase inhibitor which decreases intestinal absorption of carbohydrates. " B 27125 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1[C@H]([C@H]([C@@H]2O)O)O)CCC4=C3C=CC(=C4)O Question about this molecule: What is the mechanism of this molecule? Option A: It acts as an Androgen Receptor Antagonist. Option B: It is an Androgen Receptor Agonist. Option C: It is an Estrogen Receptor Agonist. Option D: It works as an Estrogen Receptor Agonist. " D 54739 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C1(C(=O)NC(=N1)C2=NC3=CC=CC=C3C=C2C(=O)O)C Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits ergosterol synthesis, resulting in increased cellular permeability and leakage of cellular contents. Option B: It inhibits urate crystal deposition, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Option C: It acts as a non-competitive inhibitor for an enzyme in mitochondria called cytochrome c oxidase, halting cellular respiration. Option D: It halts weed growth, eventually killing the weed or causing it to die due to its incapability to compete with surrounding vegetation. " D 129211 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC1=CC=CC=C1OCCN[C@H](C)CC2=CC(=C(C=C2)OC)S(=O)(=O)N Question about this molecule: What is the mechanism of this molecule? Option A: It acts as an Adrenergic alpha1-Agonist. Option B: It acts as an Adrenergic alpha-Antagonist. Option C: It works as an Adrenergic alpha2-Agonist. Option D: It functions as an Adrenergic beta-Antagonist. " B 2972 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=O)C=CN1C)O Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a Lead Chelating Activity. Option B: It has Acidifying Activity and Calcium Chelating Activity. Option C: It exhibits Iron Chelating Activity. Option D: It exhibits Phosphate Chelating Activity. " C 3314 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C=CC(=C1)CC=C)O Question about this molecule: What is the mechanism of this molecule? Option A: The exact mechanism of action is unknown, but it may be based on its ability to bind to and alter DNA. Option B: The precise mechanism of action is unknown, but it is postulated to block postsynaptic dopamine receptors. Option C: The exact mechanism of action is unknown, but it depresses the central nervous system. Option D: Its mechanism of action is unknown, but it interferes with action potential conduction. " D 464205 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](CN1C=NC2=C(N=CN=C21)N)OCP(=O)(O)O Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Lipase Inhibitor. Option B: It serves as a 5-alpha Reductase Inhibitor. Option C: It is a 5-alpha Reductase Inhibitor. Option D: It serves as a Nucleoside Reverse Transcriptase Inhibitor. " D 2583 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)NCC(COC1=CC=CC2=C1CCC(=O)N2)O Question about this molecule: What is the mechanism of this molecule? Option A: It serves as an adrenergic alpha-agonist. Option B: It is an adrenergic beta-antagonist. Option C: It is an adrenergic alpha-agonist. Option D: It serves as an adrenergic beta-antagonist. " B 121396 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(=O)O)[C@@H](C(=O)O)NC(=O)N Question about this molecule: What is the mechanism of this molecule? Option A: It exhibits Iron Chelating Activity. Option B: It serves as a Lead Chelating Activity. Option C: It exhibits Phosphate Chelating Activity. Option D: It functions as a Carbamoyl Phosphate Synthetase 1 Activator. " D 25102847 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F Question about this molecule: What is the mechanism of this molecule? Option A: It works as a Proteasome Inhibitor. Option B: It is a Protein Kinase Inhibitor. Option C: It works as a Protein Kinase Inhibitor. Option D: It acts as a Lipase Inhibitor. " B 4679 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C(=NC=C1)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC(F)F)OC Question about this molecule: What is the mechanism of this molecule? Option A: It works as a Proteasome Inhibitor. Option B: It acts as a Proton Pump Inhibitor. Option C: It functions as a Proton Pump Inhibitor. Option D: It acts as a Proteasome Inhibitor. " B 6291 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=C3C=CC(=C4)OC Question about this molecule: What is the mechanism of this molecule? Option A: It acts as an Androgen Receptor Antagonist. Option B: It is an Estrogen Receptor Agonist. Option C: It is an Androgen Receptor Agonist. Option D: It works as an Estrogen Receptor Agonist. " B 5311000 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@H]2[C@@H]3[C@@H](CC4=CC(=O)C=C[C@@]4([C@H]3[C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)C)Cl Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a prostaglandin receptor agonist. Option B: It serves as a corticosteroid hormone receptor agonist. Option C: It agonizes corticosteroid hormone receptors. Option D: It acts as a corticosteroid hormone receptor agonist. " D 443879 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=C(C=C1)O)[C@H](CCN(C(C)C)C(C)C)C2=CC=CC=C2 Question about this molecule: What is the mechanism of this molecule? Option A: It is a Cholinergic Antagonist and Cholinergic Muscarinic Antagonist. Option B: It works as a Cholinergic Agonist. Option C: It works as a Cholinergic Muscarinic Agonist. Option D: It is a Cholinergic Muscarinic Antagonist. " D 11504295 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(CC1=CC=C(C=C1)OC)NC[C@@H](C2=C3C(=CC(=C2)O)NC(=O)CO3)O Question about this molecule: What is the mechanism of this molecule? Option A: It acts as an Adrenergic beta2-Agonist. Option B: It is an Adrenergic beta3-Agonist. Option C: It acts as an Adrenergic beta-Agonist. Option D: It works as an Adrenergic alpha2-Agonist. " A 3337 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC(C)CC1=CC(=CC=C1)C(F)(F)F Question about this molecule: What is the mechanism of this molecule? Option A: It mimics epilepsy by blocking the inhibitory action of GABA receptors. Option B: It modulates neurotransmission to treat pharmacoresistant seizures. Option C: It alters signal conduction in neurons by blocking fast voltage-gated sodium (Na+) channels in the neuronal cell membrane responsible for signal propagation. Option D: It inhibits urate crystal deposition, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. " B 86160 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN(CC)CC1COC2(O1)CCC(CC2)C(C)(C)C Question about this molecule: What is the mechanism of this molecule? Option A: It disrupts the biosynthesis of sterols in fungi. Option B: It induces cytochrome P450 1A. Option C: It serves as a cytochrome P450 2D6 inhibitor. Option D: It is a cytochrome P450 2C9 inhibitor. " A 13344 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[K+].[K+].[K+] Question about this molecule: What is the mechanism of this molecule? Option A: It exhibits Phosphate Chelating Activity. Option B: It exhibits Alkalinizing Activity. Option C: It has Acidifying Activity and Calcium Chelating Activity. Option D: It exhibits Iron Chelating Activity. " B 2578 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCl)NC(=O)N(CCCl)N=O Question about this molecule: What is the mechanism of this molecule? Option A: It has an alkylating activity mechanism of action. Option B: It exhibits Methylating Activity. Option C: It has alkylating activity. Option D: It has an alkylating activity. " D 4497 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOC Question about this molecule: What is the mechanism of this molecule? Option A: It functions as a calcium channel antagonist and cytochrome P450 3A inhibitor. Option B: It has a sodium channel inhibition mechanism. Option C: It functions as a calcium channel antagonist. Option D: It acts as a calcium channel antagonist. " D 135398748 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC2=C(N1CCC(CO)CO)N=C(NC2=O)N Question about this molecule: What is the mechanism of this molecule? Option A: It works as a Proteasome Inhibitor. Option B: It acts as a DNA Polymerase Inhibitor. Option C: It functions as a DNA Polymerase Inhibitor. Option D: It is a Topoisomerase Inhibitor. " B 444031 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(C[C@@H]1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5 Question about this molecule: What is the mechanism of this molecule? Option A: It is a Cholinergic Muscarinic Antagonist. Option B: It works as a Cholinergic Agonist. Option C: It is a Cholinergic Antagonist and Cholinergic Muscarinic Antagonist. Option D: It works as a Cholinergic Muscarinic Agonist. " A 5656 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O Question about this molecule: What is the mechanism of this molecule? Option A: It is a Norepinephrine Uptake Inhibitor and Serotonin Uptake Inhibitor. Option B: It serves as a Serotonin Uptake Inhibitor. Option C: It acts as a Serotonin Uptake Inhibitor. Option D: It inhibits Dopamine Uptake, Norepinephrine Uptake, and Serotonin Uptake. " A 60726 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C(=C1)C(=O)C2=CC=C(C=C2)Br)N)CC(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Dipeptidase Inhibitor. Option B: It is a Cyclooxygenase Inhibitor. Option C: It acts as a Lipase Inhibitor. Option D: It works as a Cyclooxygenase Inhibitor. " B 156391 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It works as a Cyclooxygenase Inhibitor. Option B: It acts as a Dipeptidase Inhibitor. Option C: It acts as a Lipase Inhibitor. Option D: It is a Cyclooxygenase Inhibitor. " D 1349907 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C=CNC1=S Question about this molecule: What is the mechanism of this molecule? Option A: It works as a Corticosteroid Hormone Receptor Agonist. Option B: It functions as a Corticosteroid Hormone Receptor Agonist. Option C: It is a Thyroid Hormone Synthesis Inhibitor. Option D: It acts as a Progestational Hormone Receptor Antagonist. " C 657181 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6 Question about this molecule: What is the mechanism of this molecule? Option A: It is a Gonadotropin Releasing Hormone Receptor Agonist. Option B: It functions as a Corticosteroid Hormone Receptor Agonist. Option C: It works as a Corticosteroid Hormone Receptor Agonist. Option D: It acts as a Progestational Hormone Receptor Antagonist. " A 2249 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(COC1=CC=C(C=C1)CC(=O)N)O Question about this molecule: What is the mechanism of this molecule? Option A: It is an adrenergic beta-antagonist. Option B: It is an adrenergic alpha-agonist. Option C: It serves as an adrenergic alpha-agonist. Option D: It serves as an adrenergic beta-antagonist. " A 5282452 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC1C2=NC3=CC=CC=C3C(=C2/C=C/[C@H](C[C@H](CC(=O)O)O)O)C4=CC=C(C=C4)F Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Hydroxymethylglutaryl-CoA Reductase Inhibitor. Option B: It serves as a 5-alpha Reductase Inhibitor. Option C: It is a 5-alpha Reductase Inhibitor. Option D: It inhibits hydroxymethylglutaryl-CoA reductase. " A 56640146 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)C1=CC(=CC(=C1OC)C2=CC3=C(C=C2)C=C(C=C3)NS(=O)(=O)C)N4C=CC(=O)NC4=O Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a mTOR Inhibitor and Protein Kinase Inhibitor. Option B: It is a Norepinephrine Uptake Inhibitor and Serotonin Uptake Inhibitor. Option C: It is an RNA Replicase Inhibitor, UGT1A1 Inhibitor, and Breast Cancer Resistance Protein Inhibitor. Option D: It is a P-Glycoprotein Inhibitor and Breast Cancer Resistance Protein Inhibitor. " C 11234049 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1N=C(N=N1)C2=NC=C(C=C2)C3=C(C=C(C=C3)N4C[C@@H](OC4=O)CO)F Question about this molecule: What is the mechanism of this molecule? Option A: It is a breast cancer resistance protein inhibitor. Option B: It has a protein kinase inhibitor mechanism of action. Option C: It is a pan-FGFR inhibitor. Option D: It has a renin inhibitor mechanism of action. " A 4078 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)C Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a non-competitive inhibitor for an enzyme in mitochondria called cytochrome c oxidase, halting cellular respiration. Option B: It inhibits urate crystal deposition, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Option C: It acts indirectly on reticular formation, reducing neuronal activity into reticular formation without affecting its intrinsic ability to activate the cerebral cortex. Option D: It alters signal conduction in neurons by blocking fast voltage-gated sodium (Na+) channels in the neuronal cell membrane responsible for signal propagation. " C 3742 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)N(C)C1=C(C(=C(C(=C1I)C(=O)NCC(=O)NC2=C(C(=C(C(=C2I)C(=O)O)I)C(=O)NCCO)I)I)C(=O)NC)I Question about this molecule: What is the mechanism of this molecule? Option A: It functions as a X-Ray Contrast Activity. Option B: It exhibits Magnetic Resonance Contrast Activity. Option C: It is an X-Ray Contrast Activity. Option D: It has a X-Ray Contrast Activity. " C 10113978 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N Question about this molecule: What is the mechanism of this molecule? Option A: It is a Protein Kinase Inhibitor, Cytochrome P450 3A4 Inhibitor, Cytochrome P450 2D6 Inhibitor, and Cytochrome P450 2C8 Inhibitor. Option B: It acts as a Cytochrome P450 2C19 Inhibitor, Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C9 Inhibitor. Option C: It is a Protein Kinase Inhibitor, Cytochrome P450 3A4 Inhibitor, Cytochrome P450 2D6 Inhibitor, and mTOR Inhibitor. Option D: It acts as a Tyrosine Kinase Inhibitor, Cytochrome P450 3A Inhibitor, and Cytochrome P450 2C9 Inhibitor. " A 29327 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO)O)O)N=O Question about this molecule: What is the mechanism of this molecule? Option A: It mimics epilepsy by blocking the inhibitory action of GABA receptors. Option B: It alters signal conduction in neurons by blocking fast voltage-gated sodium (Na+) channels in the neuronal cell membrane responsible for signal propagation. Option C: It inhibits DNA synthesis, interferes with biochemical reactions of NAD and NADH, and inhibits some enzymes involved in gluconeogenesis. Option D: It inhibits urate crystal deposition, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. " C 4236 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)S(=O)CC(=O)N Question about this molecule: What is the mechanism of this molecule? Option A: The precise mechanism of action is unknown, but it is postulated to block postsynaptic dopamine receptors. Option B: Its exact mechanism of action is unclear, but it inhibits the reuptake of dopamine by binding to the dopamine reuptake pump, leading to an increase in extracellular dopamine. Option C: The mechanism is not known, but it presumably works via antagonism of muscarinic acetylcholine receptors and histamine H1 receptors. Option D: Its mechanism of action is not well understood, but it can block NMDA receptors and may interact with sigma receptors. " B 11167602 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F Question about this molecule: What is the mechanism of this molecule? Option A: It is a Cytochrome P450 3A Inhibitor, P-Glycoprotein Inhibitor, Cytochrome P450 1A2 Inhibitor, Cytochrome P450 2C9 Inhibitor, and Cytochrome P450 2D6 Inhibitor. Option B: It is a Cytochrome P450 3A Inhibitor, Receptor Tyrosine Kinase Inhibitor, Cytochrome P450 2B6 Inhibitor, P-Glycoprotein Inhibitor, Organic Cation Transporter 1 Inhibitor, and Organic Cation Transporter 2 Inhibitor. Option C: It serves as an AMPA Receptor Antagonist, UGT2B7 Inhibitor, UGT1A9 Inhibitor, Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C8 Inhibitor. Option D: It is a Kinase Inhibitor, Cytochrome P450 2C9 Inhibitor, Breast Cancer Resistance Protein Inhibitor, UGT1A9 Inhibitor, and UGT1A1 Inhibitor. " D 2678 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a Histamine H1 Receptor Antagonist. Option B: It is a Histamine H1 Receptor Antagonist. Option C: It serves as a Histamine Receptor Antagonist. Option D: It is a Histamine Receptor Antagonist. " B 10127622 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO Question about this molecule: What is the mechanism of this molecule? Option A: It works as a Protein Kinase Inhibitor. Option B: It acts as a mTOR Inhibitor and Protein Kinase Inhibitor. Option C: It is a Protein Kinase Inhibitor. Option D: It is a Mitogen-Activated Protein Kinase Kinase 1 Inhibitor and Mitogen-Activated Protein Kinase Kinase 2 Inhibitor. " D 54675776 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@]1([C@H]2C[C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Vitamin K Inhibitor. Option B: It can bind reversible to the bacterial 30S ribosomal subunit and block incoming aminoacyl tRNA from binding to the ribosome acceptor site. Option C: It works as a Proteasome Inhibitor. Option D: It acts as a Proteasome Inhibitor. " B 3415 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(O)P(=O)(O)O Question about this molecule: What is the mechanism of this molecule? Option A: It is a Topoisomerase Inhibitor. Option B: It is a DNA Polymerase Inhibitor and has Chelating Activity. Option C: It functions as a DNA Polymerase Inhibitor. Option D: It acts as a DNA Polymerase Inhibitor. " B 3198 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits ergosterol synthesis, resulting in increased cellular permeability and leakage of cellular contents. Option B: It acts as a non-competitive inhibitor for an enzyme in mitochondria called cytochrome c oxidase, halting cellular respiration. Option C: It inhibits urate crystal deposition, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Option D: It inhibits ergosterol synthesis, leading to increased cellular permeability. " A 135398513 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC2=C(N1COCCO)N=C(NC2=O)N Question about this molecule: What is the mechanism of this molecule? Option A: It is a Topoisomerase Inhibitor. Option B: It works as a Proteasome Inhibitor. Option C: It functions as a DNA Polymerase Inhibitor. Option D: It acts as a DNA Polymerase Inhibitor. " D 768 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C#N Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits urate crystal deposition, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Option B: It halts weed growth, eventually killing the weed or causing it to die due to its incapability to compete with surrounding vegetation. Option C: It inhibits ergosterol synthesis, resulting in increased cellular permeability and leakage of cellular contents. Option D: It acts as a non-competitive inhibitor for an enzyme in mitochondria called cytochrome c oxidase, halting cellular respiration. " D 6432 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(F)(F)F)(C(F)(F)F)(F)F Question about this molecule: What is the mechanism of this molecule? Option A: It exhibits positron emitting activity. Option B: It has ultrasound contrast activity. Option C: It has a positron emitting activity mechanism. Option D: It exhibits Magnetic Resonance Contrast Activity. " B 2157 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I Question about this molecule: What is the mechanism of this molecule? Option A: It is a Cytochrome P450 3A Inhibitor, P-Glycoprotein Inhibitor, Cytochrome P450 1A2 Inhibitor, Cytochrome P450 2C9 Inhibitor, and Cytochrome P450 2D6 Inhibitor. Option B: It acts as a Cytochrome P450 1A2 Inducer, Cytochrome P450 2B6 Inducer, Cytochrome P450 2C8 Inducer, Cytochrome P450 2C19 Inducer, Cytochrome P450 2D6 Inducer, Cytochrome P450 3A Inducer, and Cytochrome P450 2C9 Inducer. Option C: It serves as a Cytochrome P450 3A4 Inducer, Cytochrome P450 1A2 Inducer, Cytochrome P450 2B6 Inducer, Cytochrome P450 2C9 Inducer, and Cytochrome P450 2C19 Inducer. Option D: It works as a Cytochrome P450 2C19 Inhibitor, Cytochrome P450 2C9 Inhibitor, Cytochrome P450 3A4 Inducer, and Cytochrome P450 2D6 Inducer. " A 5755 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C)O Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a corticosteroid hormone receptor agonist. Option B: It agonizes corticosteroid hormone receptors. Option C: It serves as a prostaglandin receptor agonist. Option D: It serves as a corticosteroid hormone receptor agonist. " A 41693 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCC3=CC=CS3)COC Question about this molecule: What is the mechanism of this molecule? Option A: It is a Full Opioid Agonist. Option B: It acts as a Competitive Opioid Antagonist and Partial Opioid Agonist. Option C: It acts as a Partial Opioid Agonist. Option D: It acts as an Opioid mu-Receptor Agonist. " A 5284373 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Protein Kinase Inhibitor, Cytochrome P450 1A2 Inhibitor, and P-Glycoprotein Inhibitor. Option B: It is a Calcineurin Inhibitor, Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor. Option C: It is a P2Y12 Receptor Antagonist, Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor. Option D: It is an Orexin Receptor Antagonist, P-Glycoprotein Inhibitor, and Cytochrome P450 3A Inhibitor. " B 62956 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(CC1)[C@@H]2C[C@H](N(C2)C(=O)CP(=O)(CCCCC3=CC=CC=C3)O)C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It works as an Angiotensin-converting Enzyme Inhibitor. Option B: It works as an Angiotensin 2 Receptor Antagonist. Option C: It is an Angiotensin-converting Enzyme Inhibitor. Option D: It acts as an angiotensin 2 receptor antagonist. " C 216239 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F Question about this molecule: What is the mechanism of this molecule? Option A: It has a protein kinase inhibitor mechanism of action. Option B: It has a renin inhibitor mechanism of action. Option C: It has an aromatase inhibitor mechanism of action. Option D: It has a cyclooxygenase inhibitor mechanism of action. " A 4915 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NC(=O)C1=CC=C(C=C1)CNNC Question about this molecule: What is the mechanism of this molecule? Option A: It has an alkylating activity. Option B: It exhibits Methylating Activity. Option C: It has alkylating activity. Option D: It has an alkylating activity mechanism of action. " D 5493444 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[C@@H](CC1=CC(=C(C=C1)OC)OCCCOC)C[C@@H]([C@H](C[C@@H](C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N Question about this molecule: What is the mechanism of this molecule? Option A: It has a renin inhibitor mechanism of action. Option B: It has a protein kinase inhibitor mechanism of action. Option C: It has an aromatase inhibitor mechanism of action. Option D: It has a cyclooxygenase inhibitor mechanism of action. " A 54841 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1O[C@H](CCNC)C2=CC=CC=C2 Question about this molecule: What is the mechanism of this molecule? Option A: It has a norepinephrine uptake inhibitor mechanism of action. Option B: It inhibits Dopamine Uptake, Norepinephrine Uptake, and Serotonin Uptake. Option C: It is a Norepinephrine Uptake Inhibitor and Serotonin Uptake Inhibitor. Option D: It inhibits the uptake of dopamine and norepinephrine. " A 33741 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C[C@H]1CCCC[C@@]1(C2=CC(=CC=C2)OC)O Question about this molecule: What is the mechanism of this molecule? Option A: It has a protein kinase inhibitor mechanism of action. Option B: It has a full opioid agonist mechanism of action. Option C: It has a renin inhibitor mechanism of action. Option D: It has an aromatase inhibitor mechanism of action. " B 11519070 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C[N+]2(CCC1(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)CCOCC5=CC=CC=C5 Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a cholinergic antagonist. Option B: It has a cholinergic antagonist mechanism of action. Option C: It functions as a cholinergic muscarinic antagonist. Option D: It serves as a cholinergic antagonist. " B 3342 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C1=CC(=CC=C1)OC2=CC=CC=C2)C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits cyclooxygenase. Option B: It has a cyclooxygenase inhibitor mechanism of action. Option C: It has a 5-lipoxygenase inhibitor mechanism of action. Option D: It serves as a cyclooxygenase inhibitor. " B 25074887 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCNC(=O)N)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC3=CN=CC=C3)NC(=O)[C@@H](CC4=CC=C(C=C4)Cl)NC(=O)[C@@H](CC5=CC6=CC=CC=C6C=C5)NC(=O)C Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a cholinergic antagonist. Option B: It has a cholinergic antagonist mechanism of action. Option C: It has a gonadotropin releasing hormone receptor antagonist mechanism of action. Option D: It acts as a cholinergic antagonist. " C 3000322 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1[C@@H]2CC(C[C@H]1[C@H]3[C@@H]2O3)OC(=O)[C@H](CO)C4=CC=CC=C4 Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a cholinergic antagonist. Option B: It acts as a cholinergic antagonist. Option C: It functions as a cholinergic muscarinic antagonist. Option D: It has a cholinergic antagonist mechanism of action. " D 60490 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C1=CC2=CC=CC=C2S1)N(C(=O)N)O Question about this molecule: What is the mechanism of this molecule? Option A: It has a 5-lipoxygenase inhibitor mechanism of action. Option B: It has a protein kinase inhibitor mechanism of action. Option C: It has an aromatase inhibitor mechanism of action. Option D: It has a cyclooxygenase inhibitor mechanism of action. " A 3083544 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](CC1=CC=C(C=C1)OC)NC[C@@H](C2=CC(=C(C=C2)O)NC=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It acts as an Adrenergic beta-Agonist. Option B: It acts as an Adrenergic beta2-Agonist. Option C: It is an Adrenergic beta3-Agonist. Option D: It works as an Adrenergic alpha2-Agonist. " B 4946 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O Question about this molecule: What is the mechanism of this molecule? Option A: It serves as an adrenergic beta-antagonist. Option B: It is an adrenergic beta-antagonist. Option C: It is an adrenergic alpha-agonist. Option D: It serves as an adrenergic alpha-agonist. " B 6253 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)O Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits melanin synthesis. Option B: It inhibits protein kinase. Option C: It inhibits nucleic acid synthesis. Option D: It inhibits protein synthesis. " C 125017 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O Question about this molecule: What is the mechanism of this molecule? Option A: It is a Serotonin Uptake Inhibitor and Cytochrome P450 2D6 Inhibitor. Option B: It acts as a Serotonin 2c Receptor Agonist and Cytochrome P450 2D6 Inhibitor. Option C: It is a P2Y12 Receptor Antagonist, Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor. Option D: It inhibits Norepinephrine Uptake, Serotonin Uptake, and Cytochrome P450 2D6. " D 40839 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)N)O)O)CC)OC)C(=O)OC)O Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits tubulin mitotic functioning. Option B: It alters signal conduction in neurons by blocking fast voltage-gated sodium (Na+) channels in the neuronal cell membrane responsible for signal propagation. Option C: It modulates neurotransmission to treat pharmacoresistant seizures. Option D: It mimics epilepsy by blocking the inhibitory action of GABA receptors. " A 132971 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC=C4C5=CN=CC=C5)C)O Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits Kinase, Cytochrome P450 3A, Cytochrome P450 3A4, Cytochrome P450 1A2, and Breast Cancer Resistance Protein. Option B: It is a Cytochrome P450 2D6 Inhibitor and Cytochrome P450 3A4 Inducer. Option C: It inhibits Cytochrome P450 17A1, Cytochrome P450 2D6, and Cytochrome P450 2C8. Option D: It inhibits Cytochrome P450 3A4, Cytochrome P450 2C19, and Cytochrome P450 2C9. " C 439155 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CSCC[C@@H](C(=O)O)N)O)O)N Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits AdoMet-mediated processes. Option B: It selectively and reversibly inhibits MAO-A. Option C: It inhibits protein synthesis. Option D: It inhibits protein kinase. " A 135413538 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NN(C(=O)N3)P(=O)(O)O)C4=CC=C(C=C4)F Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Smoothened Receptor Antagonist. Option B: It acts as an Opioid Antagonist. Option C: It is a Histamine Receptor Antagonist. Option D: It acts as a Neurokinin 1 Antagonist. " D 43815 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4 Question about this molecule: What is the mechanism of this molecule? Option A: It works as a serotonin uptake inhibitor. Option B: It serves as a Serotonin Uptake Inhibitor. Option C: It acts as a Serotonin Uptake Inhibitor. Option D: It inhibits serotonin uptake. " D 2973 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCN)O)O)O Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a Lead Chelating Activity. Option B: It exhibits Iron Chelating Activity. Option C: It exhibits Phosphate Chelating Activity. Option D: It has Acidifying Activity and Calcium Chelating Activity. " B 5281077 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(/C=C/Cl)(C#C)O Question about this molecule: What is the mechanism of this molecule? Option A: The exact mechanism of action is unknown, but it depresses the central nervous system. Option B: The exact mechanism of action is unknown, but it may be based on its ability to bind to and alter DNA. Option C: The precise mechanism of action is unknown, but it is postulated to block postsynaptic dopamine receptors. Option D: Its mechanism of action is unknown, but it interferes with action potential conduction. " A 119432 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [13NH3] Question about this molecule: What is the mechanism of this molecule? Option A: It has a radiopharmaceutical activity mechanism of action. Option B: It is a Radiopharmaceutical Activity. Option C: It exhibits Radiopharmaceutical Activity. Option D: It exhibits Magnetic Resonance Contrast Activity. " C 3354 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(OC2=C(C1=O)C=CC=C2C(=O)OCCN3CCCCC3)C4=CC=CC=C4 Question about this molecule: What is the mechanism of this molecule? Option A: It is a Cholinergic Antagonist and Cholinergic Muscarinic Antagonist. Option B: It works as a Cholinergic Agonist. Option C: It is a Cholinergic Muscarinic Antagonist. Option D: It works as a Cholinergic Muscarinic Agonist. " C 3397 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F Question about this molecule: What is the mechanism of this molecule? Option A: It acts as an Androgen Receptor Antagonist. Option B: It is an Androgen Receptor Agonist. Option C: It works as an Estrogen Receptor Agonist. Option D: It is an Estrogen Receptor Agonist. " A 3779 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(C1=CC(=C(C=C1)O)O)O Question about this molecule: What is the mechanism of this molecule? Option A: It is an Adrenergic beta3-Agonist. Option B: It acts as an Adrenergic beta-Agonist. Option C: It works as an Adrenergic alpha2-Agonist. Option D: It acts as an Adrenergic beta2-Agonist. " B 3821 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC1(CCCCC1=O)C2=CC=CC=C2Cl Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits DNA synthesis, interferes with biochemical reactions of NAD and NADH, and inhibits some enzymes involved in gluconeogenesis. Option B: It mimics epilepsy by blocking the inhibitory action of GABA receptors. Option C: It potentiates the action of GABA on GABA-A receptors. Option D: Its mechanism of action is not well understood, but it can block NMDA receptors and may interact with sigma receptors. " D 3950 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(CC1)NC(=O)N(CCCl)N=O Question about this molecule: What is the mechanism of this molecule? Option A: It exhibits Methylating Activity. Option B: It has alkylating activity. Option C: It has an alkylating activity. Option D: It has an alkylating activity mechanism of action. " B 19493 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@H]([C@@H]1N)C2=CC=CC=C2 Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Dipeptidase Inhibitor. Option B: It acts as a Neuraminidase Inhibitor. Option C: It acts as a Monoamine Oxidase Inhibitor. Option D: It functions as a Monoamine Oxidase Inhibitor. " D 1117 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]S(=O)(=O)[O-] Question about this molecule: What is the mechanism of this molecule? Option A: It has an Ammonium Ion Binding Activity. Option B: It works through Osmotic Activity. Option C: It has Osmotic Activity. Option D: It has an Osmotic Activity. " C 247 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+](C)(C)CC(=O)[O-] Question about this molecule: What is the mechanism of this molecule? Option A: It exhibits Methylating Activity. Option B: It exhibits Phosphate Chelating Activity. Option C: It has Acidifying Activity and Calcium Chelating Activity. Option D: It exhibits Iron Chelating Activity. " A 5029 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCCCOC Question about this molecule: What is the mechanism of this molecule? Option A: It works as a Proteasome Inhibitor. Option B: It functions as a Proton Pump Inhibitor. Option C: It acts as a Proton Pump Inhibitor. Option D: It acts as a Proteasome Inhibitor. " B 6435415 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C[C@@H]1C(=O)N/C(=C\\CCCCSC[C@@H](C(=O)O)N)/C(=O)O)C Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Dipeptidase Inhibitor. Option B: It acts as a Proteasome Inhibitor. Option C: It works as a Proteasome Inhibitor. Option D: It acts as a Lipase Inhibitor. " A 3033 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl Question about this molecule: What is the mechanism of this molecule? Option A: It has a cyclooxygenase inhibitor mechanism of action. Option B: It serves as a cyclooxygenase inhibitor. Option C: It inhibits cyclooxygenase. Option D: It has a 5-lipoxygenase inhibitor mechanism of action. " B 38101 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)O)NN.O Question about this molecule: What is the mechanism of this molecule? Option A: It works as a Proteasome Inhibitor. Option B: It functions as a DOPA Decarboxylase Inhibitor. Option C: It acts as a Decarboxylase Inhibitor. Option D: It acts as a Proteasome Inhibitor. " B 3202 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[N+](C)(C)C1=CC(=CC=C1)O Question about this molecule: What is the mechanism of this molecule? Option A: It functions as a Cholinesterase Reactivator. Option B: It functions as a Cholinesterase Inhibitor. Option C: It exhibits Cholinesterase Inhibitor activity. Option D: It inhibits Cholinesterase. " C 146570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCC[C@@]1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Serotonin Uptake Inhibitor. Option B: It inhibits Dopamine Uptake, Norepinephrine Uptake, and Serotonin Uptake. Option C: It serves as a Serotonin Uptake Inhibitor. Option D: It is a Norepinephrine Uptake Inhibitor and Serotonin Uptake Inhibitor. " C 31477 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=C(C(=C1OC(=O)C)C)C)OCC(CNC(C)C)O Question about this molecule: What is the mechanism of this molecule? Option A: It functions as an Adrenergic beta-Antagonist. Option B: It acts as an Adrenergic alpha-Antagonist. Option C: It works as an Adrenergic alpha2-Agonist. Option D: It acts as an Adrenergic alpha1-Agonist. " A 9854012 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CSCCNC1=C2C(=NC(=N1)SCCC(F)(F)F)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O)O Question about this molecule: What is the mechanism of this molecule? Option A: It antagonizes P2Y12 Receptor. Option B: It acts as an Adrenergic Agonist and Histamine H1 Receptor Antagonist. Option C: It acts as a P2Y12 Receptor Antagonist. Option D: It serves as a Histamine H1 Receptor Antagonist. " C 3011155 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=NC(=NC2=C1N=CN2[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)O)N Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Nucleic Acid Synthesis Inhibitor. Option B: It functions as a Nucleic Acid Synthesis Inhibitor. Option C: It acts as a Lipase Inhibitor. Option D: It serves as a Nucleoside Reverse Transcriptase Inhibitor. " A 54678486 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)CC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It works as a Proteasome Inhibitor. Option B: It acts as a Vitamin K Inhibitor. Option C: It acts as a Proteasome Inhibitor. Option D: It acts as a Proton Pump Inhibitor. " B 33624 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)NC[C@@H](COC1=NSN=C1N2CCOCC2)O Question about this molecule: What is the mechanism of this molecule? Option A: It serves as an adrenergic beta-antagonist. Option B: It is an adrenergic beta-antagonist. Option C: It is an adrenergic alpha-agonist. Option D: It serves as an adrenergic alpha-agonist. " B 3052776 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C#CCN[C@@H]1CCC2=CC=CC=C12 Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Monoamine Oxidase Inhibitor. Option B: It acts as a Neuraminidase Inhibitor. Option C: It functions as a Monoamine Oxidase Inhibitor. Option D: It acts as a Dipeptidase Inhibitor. " A 135409453 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCN=C(N)N/N=C/C1=CNC2=C1C=C(C=C2)OC Question about this molecule: What is the mechanism of this molecule? Option A: It functions as a Serotonin 1b Receptor Agonist and Serotonin 1d Receptor Agonist. Option B: It acts as a Competitive Opioid Antagonist and Partial Opioid Agonist. Option C: It acts as an Opioid mu-Receptor Agonist. Option D: It acts as a Serotonin 4 Receptor Agonist. " D 2405 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O Question about this molecule: What is the mechanism of this molecule? Option A: It serves as an adrenergic beta-antagonist. Option B: It serves as an adrenergic alpha-agonist. Option C: It is an adrenergic beta-antagonist. Option D: It is an adrenergic alpha-agonist. " C 445643 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Proton Pump Inhibitor. Option B: It acts as a Calcineurin Inhibitor. Option C: It works as a Proteasome Inhibitor. Option D: It functions as a Proton Pump Inhibitor. " B 60815 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCC(=O)OC)C(=O)OC Question about this molecule: What is the mechanism of this molecule? Option A: It is a Full Opioid Agonist. Option B: It acts as an Opioid mu-Receptor Agonist. Option C: It acts as a Partial Opioid Agonist. Option D: It acts as a Competitive Opioid Antagonist and Partial Opioid Agonist. " A 3324 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)OCC(CCN1C=NC2=CN=C(N=C21)N)COC(=O)C Question about this molecule: What is the mechanism of this molecule? Option A: It works as a Proteasome Inhibitor. Option B: It is a Topoisomerase Inhibitor. Option C: It acts as a DNA Polymerase Inhibitor. Option D: It functions as a DNA Polymerase Inhibitor. " C 135413536 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NNC(=O)N3)C4=CC=C(C=C4)F Question about this molecule: What is the mechanism of this molecule? Option A: It is a Histamine Receptor Antagonist. Option B: It acts as an Opioid Antagonist. Option C: It acts as a Smoothened Receptor Antagonist. Option D: It acts as a Neurokinin 1 Antagonist. " D 3393 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3F Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits DNA synthesis, interferes with biochemical reactions of NAD and NADH, and inhibits some enzymes involved in gluconeogenesis. Option B: It potentiates the action of GABA on GABA-A receptors. Option C: It inhibits urate crystal deposition, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Option D: It mimics epilepsy by blocking the inhibitory action of GABA receptors. " B 6010 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@]4(C)O)C Question about this molecule: What is the mechanism of this molecule? Option A: It works as an Estrogen Receptor Agonist. Option B: It is an Androgen Receptor Agonist. Option C: It is an Estrogen Receptor Agonist. Option D: It acts as an Androgen Receptor Antagonist. " B 5328940 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Bcr-Abl Tyrosine Kinase Inhibitor. Option B: It is a Protein Kinase Inhibitor. Option C: It works as a Protein Kinase Inhibitor. Option D: It acts as a Lipase Inhibitor. " A 5284616 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC Question about this molecule: What is the mechanism of this molecule? Option A: It is a Protein Kinase Inhibitor. Option B: It works as a Protein Kinase Inhibitor. Option C: It acts as a mTOR Inhibitor and Protein Kinase Inhibitor. Option D: It acts as a Lipase Inhibitor. " C 62296 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)N(C1CCN(CC1C)CCC2=CC=CS2)C3=CC=CC=C3 Question about this molecule: What is the mechanism of this molecule? Option A: It is a class Ia antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials. Option B: It acts by preventing transmission of impulses along nerve fibers and at nerve endings. Option C: It works by inducing central nervous system (CNS) depression. Option D: It depletes the neurotransmitter of painful impulses known as substance P from the sensory nerve terminals. " C 466151 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1([C@@H](N(CCS1)S(=O)(=O)C2=CC=C(C=C2)OC3=CC=NC=C3)C(=O)NO)C Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits kinases. Option B: It inhibits matrix metalloproteinases (MMPs). Option C: It inhibits protein kinase. Option D: It inhibits protein synthesis. " B 1570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=S)N(C=C1)O Question about this molecule: What is the mechanism of this molecule? Option A: It damages iron-sulfur clusters of proteins essential for fungal metabolism and growth by increasing the cellular levels of copper. Option B: It inhibits DNA synthesis, interferes with biochemical reactions of NAD and NADH, and inhibits some enzymes involved in gluconeogenesis. Option C: It inhibits urate crystal deposition, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Option D: It mimics epilepsy by blocking the inhibitory action of GABA receptors. " A 53232 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Hydroxymethylglutaryl-CoA Reductase Inhibitor. Option B: It serves as a 5-alpha Reductase Inhibitor. Option C: It inhibits hydroxymethylglutaryl-CoA reductase. Option D: It is a 5-alpha Reductase Inhibitor. " C 2802 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3Cl Question about this molecule: What is the mechanism of this molecule? Option A: It mimics epilepsy by blocking the inhibitory action of GABA receptors. Option B: It enhances gamma-aminobutyric acid receptor responses. Option C: It is a class Ia antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials. Option D: It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent. " B 54684141 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C(=C(\\C#N)/C(=O)NC1=CC=C(C=C1)C(F)(F)F)/O Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits dihydrofolate reductase. Option B: It inhibits Dihydroorotate Dehydrogenase. Option C: It inhibits cyclooxygenase. Option D: It inhibits Isocitrate Dehydrogenase 2. " B 176870 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits protein synthesis. Option B: It inhibits protein kinase. Option C: It inhibits Janus kinase. Option D: It inhibits kinases. " B 135398508 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=C1[C@H](C[C@@H]([C@H]1CO)O)N2C=NC3=C2N=C(NC3=O)N Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a non-nucleoside reverse transcriptase inhibitor. Option B: It inhibits nucleoside reverse transcriptase. Option C: It acts as a nucleoside reverse transcriptase inhibitor. Option D: It is a nucleoside reverse transcriptase inhibitor and cytochrome P450 1A1 inhibitor. " B 4456 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C Question about this molecule: What is the mechanism of this molecule? Option A: It functions as a Cholinesterase Reactivator. Option B: It exhibits Cholinesterase Inhibitor activity. Option C: It functions as a Cholinesterase Inhibitor. Option D: It inhibits Cholinesterase. " D 444013 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCNC(=O)CN(CCN(CCN(CC(=O)NCCOC)CC(=O)[O-])CC(=O)[O-])CC(=O)[O-].[Gd+3] Question about this molecule: What is the mechanism of this molecule? Option A: It has ultrasound contrast activity. Option B: It has a positron emitting activity mechanism. Option C: It exhibits positron emitting activity. Option D: It exhibits Magnetic Resonance Contrast Activity. " D 1548972 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)N1C2=CC=CC=C2C(=C1/C=C/[C@@H](C[C@@H](CC(=O)O)O)O)C3=CC=C(C=C3)F Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a 5-alpha Reductase Inhibitor. Option B: It inhibits hydroxymethylglutaryl-CoA reductase. Option C: It acts as a Hydroxymethylglutaryl-CoA Reductase Inhibitor. Option D: It is a 5-alpha Reductase Inhibitor. " B 31307 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@H]([C@@]2(C(=O)CO)O)O)CCC4=CC(=O)C=C[C@@]43C)F)O Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a prostaglandin receptor agonist. Option B: It agonizes corticosteroid hormone receptors. Option C: It acts as a corticosteroid hormone receptor agonist. Option D: It serves as a corticosteroid hormone receptor agonist. " C 5426 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O Question about this molecule: What is the mechanism of this molecule? Option A: It activates 5-HT1D receptors on intracranial blood vessels, leading to vasoconstriction, and activates 5-HT1D receptors on sensory nerve endings of the trigeminal system, resulting in the inhibition of pro-inflammatory neuropeptide release. Option B: It inhibits serotonin reuptake, acts as a partial agonist of the 5-HT1B receptor, an agonist of 5-HT1A, and an antagonist of the 5-HT3, 5-HT1D, and 5-HT7 receptors. Option C: It modulates the release of inflammatory mediators like tumor necrosis factor-alpha (TNF-a) and other cytokine action, displaying immunosuppressive and anti-angiogenic activity. Option D: It has a high affinity for 5-HTA1 and 5-HTA2 receptors, displaying agonist activity on 5-HTA1 and antagonist on 5-HTA2, resulting in lowering of serotonin in the brain as well as an effect on increasing norepinephrine and dopamine neurotransmitters. " C 2131 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)CC1=CC=CC=C1Cl)CC2=CC=CC=C2Cl Question about this molecule: What is the mechanism of this molecule? Option A: It functions as a Cholinesterase Inhibitor. Option B: It functions as a Cholinesterase Reactivator. Option C: It exhibits Cholinesterase Inhibitor activity. Option D: It inhibits Cholinesterase. " D 121892 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)NC1=C(C=C(C=C1)NCC2=CC=C(C=C2)F)N Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits DNA Polymerase. Option B: It opens Potassium Channels. Option C: It acts as a Potassium Channel Antagonist. Option D: It functions as a DNA Polymerase Inhibitor. " B 9565 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCOC1=CN=C(N=C1)NS(=O)(=O)C2=CC=CC=C2 Question about this molecule: What is the mechanism of this molecule? Option A: It alters signal conduction in neurons by blocking fast voltage-gated sodium (Na+) channels in the neuronal cell membrane responsible for signal propagation. Option B: It lowers blood glucose by increasing the secretion of insulin from the pancreas and increasing the sensitivity of peripheral tissues to insulin. Option C: It inhibits urate crystal deposition, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Option D: It stimulates the secretion of insulin granules from pancreatic islet beta cells by blocking ATP-sensitive potassium channels (KATP channels) and causing depolarization of the beta cells. " B 39186 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)O[C@@H]1[C@@H](SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC Question about this molecule: What is the mechanism of this molecule? Option A: It is a Kinase Inhibitor and Cytochrome P450 3A Inhibitor. Option B: It is a Serotonin Uptake Inhibitor and Cytochrome P450 2D6 Inhibitor. Option C: It is a Protein Kinase Inhibitor and Cytochrome P450 3A4 Inhibitor. Option D: It acts as a Calcium Channel Antagonist and Cytochrome P450 3A4 Inhibitor. " D 187 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)OCC[N+](C)(C)C Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a cholinergic antagonist. Option B: It functions as a cholinergic muscarinic antagonist. Option C: It acts as a cholinergic agonist. Option D: It acts as a cholinergic antagonist. " C 4168 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl Question about this molecule: What is the mechanism of this molecule? Option A: It functions as a Dopamine Agonist. Option B: It serves as a dopamine agonist. Option C: It acts as a dopamine agonist. Option D: It acts as a dopamine D2 antagonist. " D 4485 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC Question about this molecule: What is the mechanism of this molecule? Option A: It has a sodium channel inhibition mechanism. Option B: It functions as a calcium channel antagonist and cytochrome P450 3A inhibitor. Option C: It acts as a calcium channel antagonist. Option D: It functions as a calcium channel antagonist. " C 84029 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)O)(C)O Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits Bcr-Abl tyrosine kinase, cytochrome P450 3A4, and cytochrome P450 2D6. Option B: It inhibits cytochrome P450 3A4, cytochrome P450 3A, and P-glycoprotein. Option C: It inhibits HCV NS3/4A protease, cytochrome P450 3A4, and cytochrome P450 3A5. Option D: It is an androgen receptor antagonist, cytochrome P450 3A4 inducer, cytochrome P450 2C9 inducer, and cytochrome P450 2C19 inducer. " B 441350 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@](CC1=CC=C(C=C1)O)(C(=O)O)N Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits catecholamine synthesis. Option B: It suppresses hunger signals and appetite by increasing catecholamine levels. Option C: It blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins. Option D: It acts on brain catecholaminergic neurons and inhibits dopamine uptake. " A 2784 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+]12CCC(CC1)C(C2)OC(=O)C(C3=CC=CC=C3)(C4=CC=CC=C4)O Question about this molecule: What is the mechanism of this molecule? Option A: It has a cholinergic antagonist mechanism of action. Option B: It acts as a cholinergic antagonist. Option C: It serves as a cholinergic antagonist. Option D: It functions as a cholinergic muscarinic antagonist. " B 5284514 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)/C(=C\\CN2CCCC2)/C3=CC=CC(=N3)/C=C/C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It antagonizes smoothened receptors. Option B: It antagonizes histamine H1 receptors. Option C: It antagonizes adenosine A3 receptors. Option D: It antagonizes histamine H2 receptors. " B 999 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)CC(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It serves as an irrigation. Option B: It has an Ammonium Ion Binding Activity. Option C: It serves as an adrenergic beta-antagonist. Option D: It binds to ammonium ions. " D 44093 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](CS)C(=O)N1CCC[C@H]1C(=O)O Question about this molecule: What is the mechanism of this molecule? Option A: It works as an Angiotensin 2 Receptor Antagonist. Option B: It has an angiotensin-converting enzyme inhibitor mechanism of action. Option C: It works as an Angiotensin-converting Enzyme Inhibitor. Option D: It inhibits angiotensin-converting enzyme. " D 47811 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN1C[C@@H](C[C@H]2[C@H]1CC3=CNC4=CC=CC2=C34)CSC Question about this molecule: What is the mechanism of this molecule? Option A: It functions as a Dopamine Agonist. Option B: It serves as a dopamine agonist. Option C: It acts as a dopamine D2 antagonist. Option D: It acts as a dopamine agonist. " D 8612 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCOC(=O)C1=C(C=C(C=C1)N)Cl Question about this molecule: What is the mechanism of this molecule? Option A: It lowers blood glucose by increasing the secretion of insulin from the pancreas and increasing the sensitivity of peripheral tissues to insulin. Option B: It increases the threshold for electrical excitation in nerves by slowing the propagation of the nerve impulse and reducing the rate of rise of the action potential. Option C: It acts indirectly on reticular formation, reducing neuronal activity into reticular formation without affecting its intrinsic ability to activate the cerebral cortex. Option D: It alters signal conduction in neurons by blocking fast voltage-gated sodium (Na+) channels in the neuronal cell membrane responsible for signal propagation. " B 5284570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3C(=O)CC4 Question about this molecule: What is the mechanism of this molecule? Option A: It acts as an Opioid mu-Receptor Agonist. Option B: It is a Full Opioid Agonist. Option C: It acts as a Partial Opioid Agonist. Option D: It acts as a Competitive Opioid Antagonist and Partial Opioid Agonist. " B 77991 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(C)C(=O)OC1=CC=CC(=C1)[C@H](C)N(C)C Question about this molecule: What is the mechanism of this molecule? Option A: It functions as a cholinergic muscarinic antagonist. Option B: It serves as a cholinergic antagonist. Option C: It acts as a cholinesterase inhibitor. Option D: It acts as a cholinergic antagonist. " C 6918638 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)/C=C/C(=O)NO Question about this molecule: What is the mechanism of this molecule? Option A: It operates as a selective GABA reuptake inhibitor. Option B: It acts as a histone deacetylase inhibitor. Option C: It works as a serotonin uptake inhibitor. Option D: It is a kinase inhibitor and P-glycoprotein inhibitor. " B 10100 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)O[C@](CC1=CC=CC=C1)(C2=CC=CC=C2)[C@H](C)CN(C)C Question about this molecule: What is the mechanism of this molecule? Option A: It acts as an Opioid mu-Receptor Agonist. Option B: It acts as a Partial Opioid Agonist. Option C: It is a Full Opioid Agonist. Option D: It acts as a Competitive Opioid Antagonist and Partial Opioid Agonist. " C 1990 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)NO Question about this molecule: What is the mechanism of this molecule? Option A: It is an adrenergic beta-antagonist. Option B: It is an adrenergic alpha-agonist. Option C: It acts as an urease inhibitor. Option D: It serves as an adrenergic beta-antagonist. " C 2284 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C(CC(=O)O)CN)Cl Question about this molecule: What is the mechanism of this molecule? Option A: It serves as a neurokinin 1 antagonist, cytochrome P450 2D6 inhibitor, breast cancer resistance protein inhibitor, and P-glycoprotein inhibitor. Option B: It acts as a cholinergic agonist and cholinergic muscarinic agonist. Option C: It acts as a GABA A agonist and GABA B agonist. Option D: It has a partial cholinergic nicotinic agonist and cholinergic agonist mechanism of action. " C 5991 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=C3C=CC(=C4)O Question about this molecule: What is the mechanism of this molecule? Option A: It is an Androgen Receptor Agonist. Option B: It works as an Estrogen Receptor Agonist. Option C: It acts as an Androgen Receptor Antagonist. Option D: It is an Estrogen Receptor Agonist. " D 5625 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NC1=C(N=CC=C1)N2CCN(CC2)C(=O)C3=CC4=C(N3)C=CC(=C4)NS(=O)(=O)C Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a non-nucleoside reverse transcriptase inhibitor. Option B: It acts as a nucleoside reverse transcriptase inhibitor. Option C: It inhibits nucleoside reverse transcriptase. Option D: It is a nucleoside reverse transcriptase inhibitor and cytochrome P450 1A1 inhibitor. " A 2662 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a Dipeptidase Inhibitor. Option B: It works as a Cyclooxygenase Inhibitor. Option C: It is a Cyclooxygenase Inhibitor. Option D: It acts as a Lipase Inhibitor. " C 4189 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl Question about this molecule: What is the mechanism of this molecule? Option A: It acts as a non-competitive inhibitor for an enzyme in mitochondria called cytochrome c oxidase, halting cellular respiration. Option B: It inhibits ergosterol synthesis, leading to increased cellular permeability. Option C: It inhibits urate crystal deposition, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Option D: It inhibits ergosterol synthesis, resulting in increased cellular permeability and leakage of cellular contents. " B 3100 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2 Question about this molecule: What is the mechanism of this molecule? Option A: It is a Histamine Receptor Antagonist. Option B: It is a Histamine H1 Receptor Antagonist. Option C: It serves as a Histamine Receptor Antagonist. Option D: It serves as a Histamine H1 Receptor Antagonist. " B 3455 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F Question about this molecule: What is the mechanism of this molecule? Option A: It blocks dopamine reuptake with a slower dissociation rate than cocaine. Option B: Its mechanism of action is not well understood, but it can block NMDA receptors and may interact with sigma receptors. Option C: The precise mechanism of action is unknown, but it is postulated to block postsynaptic dopamine receptors. Option D: Its exact mechanism of action is unclear, but it inhibits the reuptake of dopamine by binding to the dopamine reuptake pump, leading to an increase in extracellular dopamine. " A 122087 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C)(C(=O)CCl)NC(=O)C1=CC(=C(C(=C1)Cl)C)Cl Question about this molecule: What is the mechanism of this molecule? Option A: It inhibits topoisomerase. Option B: It inhibits DNA Polymerase. Option C: It inhibits DNA-dependent RNA polymerase. Option D: It inhibits nuclear division. " D 4114 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2 Question about this molecule: What is the mechanism of this molecule? Option A: It exhibits positron emitting activity. Option B: It exhibits photoabsorption. Option C: It undergoes photoabsorption. Option D: It exhibits Magnetic Resonance Contrast Activity. " C 5311065 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C[C@H](N(C1)C(=O)[C@@H]2CSSCCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(=O)N Question about this molecule: What is the right information about this molecule's medical effects? Option A: It mainly acts on the cells of the distal part of the nephron and the collecting tubules in the kidney. Option B: It inhibits beta-tubulin synthesis, inhibiting development of germ tubes and the growth of mycelia. Option C: It induces bronchoconstriction through muscarinic receptors in the lungs. Option D: It inhibits glucose reabsorption in the proximal tubule of the nephron and causes glycosuria. " A 5584 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CN1C2=CC=CC=C2CCC3=CC=CC=C31)CN(C)C Question about this molecule: What is the right information about this molecule's medical effects? Option A: During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option B: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option C: It blocks the D2 somatodendritic autoreceptor, resulting in the blockade of postsynaptic dopamine receptors in the mesolimbic system and an increased dopamine turnover. Option D: It acts by decreasing the reuptake of norepinephrine and serotonin (5-HT). " D 2520 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC Question about this molecule: What is the right information about this molecule's medical effects? Option A: It opens calcium-dependent inwardly rectifying potassium channels (OP1 receptor agonist). Option B: It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. Option C: It is a calcium channel blocker that is a class IV anti-arrhythmia agent. Option D: It stabilizes voltage-gated L-type calcium channels in vascular smooth muscle cells. " C 4004 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)CC(C(=O)OCC)SP(=S)(OC)OC Question about this molecule: What is the right information about this molecule's medical effects? Option A: It binds irreversibly to cholinesterase. Option B: It is a centrally acting reversible acetyl cholinesterase inhibitor. Option C: This molecule exerts its actions against myasthenia gravis by competitive, reversible inhibition of acetylcholinesterase. Option D: It acts by interfering with an essential nervous system enzyme, cholinesterase. " A 4760 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2C(=O)C3=CC=CC=C3C2=O Question about this molecule: What is the right information about this molecule's medical effects? Option A: It has a higher incidence of severe adverse effects. Option B: It is a common active ingredient in toothpaste, exerting an anti-sensitivity action. Option C: It has a non-systemic action with long residual activity. Option D: It has a broad spectrum of action, being systemic with protective and curative action. " A 208898 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C)C(=O)C3=CC=C(C=C3)OCCCN(CCCC)CCCC Question about this molecule: What is the right information about this molecule's medical effects? Option A: It activates glutamatergic circuits while inhibiting GABA. Option B: It blocks beta-adrenergic receptors in the heart, leading to decreased force and rate of heart contractions. Option C: It works to control rhythm and rate in atrial fibrillation. Option D: It prevents transmission of impulses along nerve fibers and at nerve endings. " C 2733526 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC/C(=C(\\C1=CC=CC=C1)/C2=CC=C(C=C2)OCCN(C)C)/C3=CC=CC=C3 Question about this molecule: What is the right information about this molecule's medical effects? Option A: It inhibits DNA synthesis and interacts with SH groups. Option B: Its action is driven by the competitive and reversible inhibition of the factor Xa. Option C: It induces a conformational change in the estrogen receptors (ER). Option D: It blocks RNA synthesis and ribosome function, and is used mainly as a tool in biochemistry. " C 25154714 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[C@@H](C(=O)N1CCC[C@H]1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)[C@@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)OC)NC(=O)OC Question about this molecule: What is the right information about this molecule's medical effects? Option A: It disrupts the function of new HCV replication complexes by modulating the NS5A phosphorylation status. Option B: Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. Option C: It exerts its action by binding on the benzodiazepine receptor complex and modulation of the GABABZ receptor chloride channel macromolecular complex. Option D: Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization. " A 9294 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]([C@@H](C1=CC=CC=C1)O)NC Question about this molecule: What is the right information about this molecule's medical effects? Option A: It blocks the D2 somatodendritic autoreceptor, resulting in the blockade of postsynaptic dopamine receptors in the mesolimbic system and an increased dopamine turnover. Option B: It causes the release of noradrenaline by acting on the adrenergic nerve terminals and alpha- and beta-receptors. Option C: It increases the activity of norepinephrine (noradrenalin) on adrenergic receptors. Option D: It exerts its action by binding on the benzodiazepine receptor complex and modulation of the GABABZ receptor chloride channel macromolecular complex. " C 4095 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2 Question about this molecule: What is the right information about this molecule's medical effects? Option A: It has a broad spectrum of action, being systemic with protective and curative action. Option B: It is a common active ingredient in toothpaste, exerting an anti-sensitivity action. Option C: It has a non-systemic action with long residual activity. Option D: It has a depressant action on the cough center. " D 4775 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)CCCC(=O)O Question about this molecule: What is the right information about this molecule's medical effects? Option A: It acts by inhibition of mitochondrial respiration. Option B: It acts by inhibiting nuclear division. Option C: It promotes an alternative pathway of nitrogen elimination. Option D: It blocks neuromuscular transmission. " C 5610 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CCN)O Question about this molecule: What is the right information about this molecule's medical effects? Option A: It acts at inhibitory synapses in the brain. Option B: It induces the release of catecholamine. Option C: It blocks neuromuscular transmission. Option D: It induces a conformational change in the estrogen receptors (ER). " B 3325 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(N=C(S1)N=C(N)N)CSCCC(=NS(=O)(=O)N)N Question about this molecule: What is the right information about this molecule's medical effects? Option A: It inhibits functioning of postsynaptic dopamine receptors. Option B: It inhibits gastric acid secretion. Option C: It activates glutamatergic circuits while inhibiting GABA. Option D: It inhibits fungal cell membrane synthesis. " B 2337 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C1=CC=C(C=C1)N Question about this molecule: What is the right information about this molecule's medical effects? Option A: It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. Option B: It inhibits sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. Option C: It prevents transmission of impulses along nerve fibers and at nerve endings. Option D: It alters signal conduction in neurons by blocking the fast voltage gated sodium (Na+) channels in the neuronal cell membrane that are responsible for signal propagation. " C 2366 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNCCC1=CC=CC=N1 Question about this molecule: What is the right information about this molecule's medical effects? Option A: It blocks the action of endogenous histamine, leading to temporary relief of the negative symptoms brought on by histamine. Option B: It inhibits functioning of postsynaptic dopamine receptors. Option C: It blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins. Option D: It can reduce symptoms through its actions on histamine receptors. " D 4616 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O Question about this molecule: What is the right information about this molecule's medical effects? Option A: It activates glutamatergic circuits while inhibiting GABA. Option B: It inhibits functioning of postsynaptic dopamine receptors. Option C: It produces inhibitory postsynaptic potentials. Option D: It selectively targets mutant proteins in malignant cells, acting similarly to erlotinib. " C 3410 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O Question about this molecule: What is the right information about this molecule's medical effects? Option A: It blocks RNA synthesis and ribosome function, and is used mainly as a tool in biochemistry. Option B: It dilates and relaxes airways. Option C: It induces a conformational change in the estrogen receptors (ER). Option D: It inhibits DNA synthesis and interacts with SH groups. " B 25429 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)NC1=NC2=CC=CC=C2N1 Question about this molecule: What is the right information about this molecule's medical effects? Option A: It inhibits spinal polysynaptic afferent pathways and, to a lesser extent, monosynaptic afferent pathways. Option B: It induces bronchoconstriction through muscarinic receptors in the lungs. Option C: It inhibits glucose reabsorption in the proximal tubule of the nephron and causes glycosuria. Option D: It inhibits beta-tubulin synthesis, inhibiting development of germ tubes and the growth of mycelia. " D 2118 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NN=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4 Question about this molecule: What is the right information about this molecule's medical effects? Option A: Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. Option B: Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization. Option C: It induces bronchoconstriction through muscarinic receptors in the lungs. Option D: It opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. " D 38853 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)O)N Question about this molecule: What is the right information about this molecule's medical effects? Option A: It is used in cereal seed dressing and fungicidal non-mercurial seed dressing with special action against fusarium. Option B: It is a centrally acting sympatholytic agent and an antihypertensive agent. Option C: It selectively targets mutant proteins in malignant cells, acting similarly to erlotinib. Option D: It is a commonly used oral antihypertensive agent that acts by inducing peripheral vasodilation. " B 68617 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN[C@H]1CC[C@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl Question about this molecule: What is the right information about this molecule's medical effects? Option A: It blocks the D2 somatodendritic autoreceptor, resulting in the blockade of postsynaptic dopamine receptors in the mesolimbic system and an increased dopamine turnover. Option B: It has three distinct pharmacological actions: (1) stimulation of presynaptic 5-HT1D receptors, (2) direct inhibition of trigeminal nuclei cell excitability via 5-HT1B/1D receptor agonism in the brainstem, and (3) vasoconstriction of meningeal, dural, cerebral or pial vessels as a result of vascular 5-HT1B receptor agonism. Option C: During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option D: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. " D 2809 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)C(=O)O Question about this molecule: What is the right information about this molecule's medical effects? Option A: Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization. Option B: It induces bronchoconstriction through muscarinic receptors in the lungs. Option C: Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. Option D: It opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. " D 4054 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC12CC3CC(C1)(CC(C3)(C2)N)C Question about this molecule: What is the right information about this molecule's medical effects? Option A: Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. Option B: Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization. Option C: It blocks the effects of glutamate, a neurotransmitter in the brain that leads to neuronal excitability and excessive stimulation in Alzheimer's Disease. Option D: It works by blocking the transporter reuptake proteins for key neurotransmitters affecting mood, thereby leaving more active neurotransmitter in the synapse. " C 5743 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C Question about this molecule: What is the right information about this molecule's medical effects? Option A: It activates glutamatergic circuits while inhibiting GABA. Option B: It reduces deaths in patients requiring ventilation and oxygen. Option C: Patients are advised to immediately contact their healthcare provider if a rash develops. Option D: It selectively targets mutant proteins in malignant cells, acting similarly to erlotinib. " B 2756 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(N=CN1)CSCCNC(=NC)NC#N Question about this molecule: What is the right information about this molecule's medical effects? Option A: It blocks the activity of cytochrome P-450. Option B: It blocks production of estrogens by competitive, reversible binding to the heme of its cytochrome P450 unit. Option C: It acts indirectly on reticular formation, whereby neuronal activity into reticular formation is reduced without affecting its intrinsic ability to activate the cerebral cortex. Option D: Increased amounts of Ca2+ are then stored in the sarcoplasmic reticulum and released by each action potential, which is unchanged by digoxin. " A 2484 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)C1=CC=C(C=C1)CN(C)CC2=CC=CC3=CC=CC=C32 Question about this molecule: What is the right information about this molecule's medical effects? Option A: It binds to keratin in human cells, then once it reaches the fungal site of action, it binds to fungal microtubes thus altering the fungal process of mitosis. Option B: It inhibits the activity of the squalene epoxidase enzyme that is essential in the formation of sterols necessary for fungal cell membranes. Option C: It mediates its action by increasing the cellular levels of copper, and damaging iron-sulfur clusters of proteins essential for fungal metabolism and growth. Option D: It inhibits beta-tubulin synthesis, inhibiting development of germ tubes and the growth of mycelia. " B 2942 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)N=NC1=C(NC=N1)C(=O)N Question about this molecule: What is the right information about this molecule's medical effects? Option A: It inhibits DNA synthesis and interacts with SH groups. Option B: Its action is driven by the competitive and reversible inhibition of the factor Xa. Option C: It blocks RNA synthesis and ribosome function, and is used mainly as a tool in biochemistry. Option D: It induces a conformational change in the estrogen receptors (ER). " A 82153 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CO)C[C@@H](C5=CC(=O)C=C[C@]35C)F)O Question about this molecule: What is the right information about this molecule's medical effects? Option A: It is a common active ingredient in toothpaste, exerting an anti-sensitivity action. Option B: It has a non-systemic action with long residual activity. Option C: It has anti-inflammatory actions. Option D: It has a broad spectrum of action, being systemic with protective and curative action. " C 15546 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)N2C(=O)C(=C(C=N2)N)Cl Question about this molecule: What is the right information about this molecule's medical effects? Option A: It activates glutamatergic circuits while inhibiting GABA. Option B: It inhibits photosynthesis and the Hill reaction in plants. Option C: It inhibits fungal cell membrane synthesis. Option D: It inhibits photosynthesis by disrupting photosystem II. " B 5284596 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O Question about this molecule: What is the right information about this molecule's medical effects? Option A: It acts indirectly on reticular formation, whereby neuronal activity into reticular formation is reduced without affecting its intrinsic ability to activate the cerebral cortex. Option B: It induces bronchoconstriction through muscarinic receptors in the lungs. Option C: Increased amounts of Ca2+ are then stored in the sarcoplasmic reticulum and released by each action potential, which is unchanged by digoxin. Option D: It has a high affinity for μ-opioid receptors and acts as an inverse agonist. " D 441244 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CN=C(N=C1)[N-]S(=O)(=O)C2=CC=C(C=C2)N.[Ag+] Question about this molecule: What is the right information about this molecule's medical effects? Option A: It interferes with the synthesis of vital cell wall components, which leads to cell death. Option B: It exerts a non-genomic action by targeting important signaling molecules in vascular endothelial cells (ECs). Option C: It binds to surface membranes and proteins, causing proton leaks and cell death. Option D: Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. " C 5280961 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O Question about this molecule: What is the right information about this molecule's medical effects? Option A: It induces bronchoconstriction through muscarinic receptors in the lungs. Option B: It exerts a non-genomic action by targeting important signaling molecules in vascular endothelial cells (ECs). Option C: It stimulates the secretion of insulin granules from pancreatic islet beta cells by blocking ATP-sensitive potassium channels (KATP channels) and causing depolarization of the beta cells. Option D: It inhibits beta-tubulin synthesis, inhibiting development of germ tubes and the growth of mycelia. " B 59768 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(COC1=CC=C(C=C1)CCC(=O)OC)O Question about this molecule: What is the right information about this molecule's medical effects? Option A: It blocks beta-adrenergic receptors in the heart, leading to decreased force and rate of heart contractions. Option B: It blocks the action of androgens of adrenal and testicular origin that stimulate the growth of normal and malignant prostatic tissue. Option C: It relaxes the smooth muscle of the bladder in the treatment of urinary frequency and incontinence. Option D: It relaxes the muscles in the prostate and bladder neck, used in the symptomatic treatment of BPH. " A 4914 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCOC(=O)C1=CC=C(C=C1)N Question about this molecule: What is the right information about this molecule's medical effects? Option A: It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. Option B: It inhibits sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. Option C: It alters signal conduction in neurons by blocking the fast voltage gated sodium (Na+) channels in the neuronal cell membrane that are responsible for signal propagation. Option D: It may act by blocking repetitive firing of voltage-gated sodium channels leading to a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. " B 29393 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN(CCC)C1=C(C=C(C=C1[N+](=O)[O-])S(=O)(=O)N)[N+](=O)[O-] Question about this molecule: What is the right information about this molecule's medical effects? Option A: It inhibits beta-tubulin synthesis, inhibiting development of germ tubes and the growth of mycelia. Option B: This molecule acts by causing the arrest of cells in metaphase mitosis through its inhibition tubulin mitotic functioning. Option C: It disrupts microtubules, blocking anisotropic growth of plant cells. Option D: It induces bronchoconstriction through muscarinic receptors in the lungs. " C 2327 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C(=C1CNNC(=O)C(CO)N)O)O)O Question about this molecule: What is the right information about this molecule's medical effects? Option A: It inhibits glucose reabsorption in the proximal tubule of the nephron and causes glycosuria. Option B: It inhibits beta-tubulin synthesis, inhibiting development of germ tubes and the growth of mycelia. Option C: It inhibits the activity of the squalene epoxidase enzyme that is essential in the formation of sterols necessary for fungal cell membranes. Option D: It prevents the formation of dopamine from levodopa in extracerebral tissues, minimizing extracerebral side effects. " D 2730 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OC1=NC(=C(C=C1Cl)Cl)Cl Question about this molecule: What is the right information about this molecule's medical effects? Option A: This molecule exerts its actions against myasthenia gravis by competitive, reversible inhibition of acetylcholinesterase. Option B: It acts as an acetylcholinesterase inhibitor to control insects in a wide range of crops. Option C: It is non-systemic with contact and stomach action, and an acetylcholinesterase (AChE) inhibitor. Option D: It inhibits acetylcholinesterase in the nervous system of insects. " D 9502 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C(=O)NC1=CC(=C(C=C1)Cl)Cl)OC Question about this molecule: What is the right information about this molecule's medical effects? Option A: It is used in cereal seed dressing and fungicidal non-mercurial seed dressing with special action against fusarium. Option B: This occurrence led to the development of novel second-generation ALK inhibitors such as this molecule to overcome crizotinib resistance. Option C: It selectively targets mutant proteins in malignant cells, acting similarly to erlotinib. Option D: It is an herbicide for the control of annual grass and broad-leaved weeds. " D 5379 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1CN(CCN1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F Question about this molecule: What is the right information about this molecule's medical effects? Option A: It binds to surface membranes and proteins, causing proton leaks and cell death. Option B: It inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. Option C: Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. Option D: It inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. " B 66461 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(CN1C=NC=N1)(C2=C(C=C(C=C2)Cl)Cl)O Question about this molecule: What is the right information about this molecule's medical effects? Option A: It has a non-systemic action with long residual activity. Option B: Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. Option C: It is a common active ingredient in toothpaste, exerting an anti-sensitivity action. Option D: It has a broad spectrum of action, being systemic with protective and curative action. " D 38409 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CSC(=C1)C(=O)C2=C(C(=C(C=C2)OCC(=O)O)Cl)Cl Question about this molecule: What is the right information about this molecule's medical effects? Option A: It aims to target the underlying disease by blocking the effects of the primary androgen involved in benign prostate hyperplasia and androgenic alopecia, thus reducing the risk for secondary complications while providing symptom control. Option B: It is a diuretic drug with uric acid-lowering action which was marketed for the treatment of hypertension. Option C: Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization. Option D: Dopamine-antagonizing medications such as this molecule are though to improve psychotic symptoms and states that are caused by an over-production of dopamine, such as schizophrenia, which is theorized to be caused by a hyperdopaminergic state within the limbic system of the brain. " B 3676 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CC(=O)NC1=C(C=CC=C1C)C Question about this molecule: What is the right information about this molecule's medical effects? Option A: It inhibits sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. Option B: It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. Option C: It alters signal conduction in neurons by blocking the fast voltage gated sodium (Na+) channels in the neuronal cell membrane that are responsible for signal propagation. Option D: It may act by blocking repetitive firing of voltage-gated sodium channels leading to a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. " C 38779 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCSP(=O)(OCC)OC1=C(C=C(C=C1)Br)Cl Question about this molecule: What is the right information about this molecule's medical effects? Option A: It inhibits acetylcholinesterase in the nervous system of insects. Option B: This molecule exerts its actions against myasthenia gravis by competitive, reversible inhibition of acetylcholinesterase. Option C: It acts as an acetylcholinesterase inhibitor to control insects in a wide range of crops. Option D: It is non-systemic with contact and stomach action, and an acetylcholinesterase (AChE) inhibitor. " D 4499 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC Question about this molecule: What is the right information about this molecule's medical effects? Option A: It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. Option B: It binds to angiotensin II type 1 (AT1) receptors, inhibiting the action of angiotensin II on vascular smooth muscle and reducing arterial blood pressure. Option C: Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization. Option D: It may act by blocking repetitive firing of voltage-gated sodium channels leading to a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. " A 4917 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl Question about this molecule: What is the right information about this molecule's medical effects? Option A: It has three distinct pharmacological actions: (1) stimulation of presynaptic 5-HT1D receptors, (2) direct inhibition of trigeminal nuclei cell excitability via 5-HT1B/1D receptor agonism in the brainstem, and (3) vasoconstriction of meningeal, dural, cerebral or pial vessels as a result of vascular 5-HT1B receptor agonism. Option B: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option C: It blocks the D2 somatodendritic autoreceptor, resulting in the blockade of postsynaptic dopamine receptors in the mesolimbic system and an increased dopamine turnover. Option D: During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. " C 2968 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C Question about this molecule: What is the right information about this molecule's medical effects? Option A: It blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. Option B: It is thought that this molecule acts by blocking central cholinergic receptors, and thus balancing cholinergic and dopaminergic activity in the basal ganglia. Option C: It induces bronchoconstriction through muscarinic receptors in the lungs. Option D: It is similar to acetylcholine and acts as a partial agonist of the nicotinic acetylcholine receptor. " D 2771 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F Question about this molecule: What is the right information about this molecule's medical effects? Option A: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option B: It blocks the D2 somatodendritic autoreceptor, resulting in the blockade of postsynaptic dopamine receptors in the mesolimbic system and an increased dopamine turnover. Option C: It has three distinct pharmacological actions: (1) stimulation of presynaptic 5-HT1D receptors, (2) direct inhibition of trigeminal nuclei cell excitability via 5-HT1B/1D receptor agonism in the brainstem, and (3) vasoconstriction of meningeal, dural, cerebral or pial vessels as a result of vascular 5-HT1B receptor agonism. Option D: During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. " D 3333 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C Question about this molecule: What is the right information about this molecule's medical effects? Option A: It binds to angiotensin II type 1 (AT1) receptors, inhibiting the action of angiotensin II on vascular smooth muscle and reducing arterial blood pressure. Option B: It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. Option C: Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization. Option D: It may act by blocking repetitive firing of voltage-gated sodium channels leading to a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. " B 5329098 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=C(N1)/C=C\\2/C3=CC=CC=C3NC2=O)C Question about this molecule: What is the right information about this molecule's medical effects? Option A: It blocks the D2 somatodendritic autoreceptor, resulting in the blockade of postsynaptic dopamine receptors in the mesolimbic system and an increased dopamine turnover. Option B: During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option C: It is a thrombopoiesis stimulating dimer Fc-peptide fusion protein (peptibody) to increase platelet production through activation of the thrombopoietin receptor. Option D: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. " C 5853 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=O)(C(C(Cl)(Cl)Cl)O)OC Question about this molecule: What is the right information about this molecule's medical effects? Option A: It acts as an acetylcholinesterase inhibitor to control insects in a wide range of crops. Option B: It acts by interfering with an essential nervous system enzyme, cholinesterase. Option C: This molecule exerts its actions against myasthenia gravis by competitive, reversible inhibition of acetylcholinesterase. Option D: It inhibits acetylcholinesterase in the nervous system of insects. " B 2444 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCOC(C1=CC=CC=C1)C2=CC=C(C=C2)Br Question about this molecule: What is the right information about this molecule's medical effects? Option A: It can reduce symptoms through its actions on histamine receptors. Option B: It blocks the action of endogenous histamine, leading to temporary relief of the negative symptoms brought on by histamine. Option C: It competes with free histamine for binding at HA-receptor sites. Option D: It blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins. " C 6518 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(CO[N+](=O)[O-])(CO[N+](=O)[O-])CO[N+](=O)[O-])O[N+](=O)[O-] Question about this molecule: What is the right information about this molecule's medical effects? Option A: It blocks the neurotransmitter dopamine and the vagus nerve in the gastrointestinal tract. Option B: It works by releasing the signaling gas nitric oxide in the body. Option C: It mainly acts on the cells of the distal part of the nephron and the collecting tubules in the kidney. Option D: It is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. " B 3261 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C2=NN=CN2C3=C(C=C(C=C3)Cl)C(=N1)C4=CC=CC=C4 Question about this molecule: What is the right information about this molecule's medical effects? Option A: Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. Option B: It binds to angiotensin II type 1 (AT1) receptors, inhibiting the action of angiotensin II on vascular smooth muscle and reducing arterial blood pressure. Option C: Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization. Option D: It induces bronchoconstriction through muscarinic receptors in the lungs. " A 3386 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F Question about this molecule: What is the right information about this molecule's medical effects? Option A: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option B: During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option C: It blocks the D2 somatodendritic autoreceptor, resulting in the blockade of postsynaptic dopamine receptors in the mesolimbic system and an increased dopamine turnover. Option D: It has three distinct pharmacological actions: (1) stimulation of presynaptic 5-HT1D receptors, (2) direct inhibition of trigeminal nuclei cell excitability via 5-HT1B/1D receptor agonism in the brainstem, and (3) vasoconstriction of meningeal, dural, cerebral or pial vessels as a result of vascular 5-HT1B receptor agonism. " B 5388962 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)O Question about this molecule: What is the right information about this molecule's medical effects? Option A: It blocks neuromuscular transmission. Option B: It works to reduce blood pressure and blood fluid volume. Option C: It acts to lower blood pressure. Option D: It acts by inhibiting nuclear division. " B 135398687 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]([C@@H](C1=NC2=C(NC1)N=C(NC2=O)N)O)O Question about this molecule: What is the right information about this molecule's medical effects? Option A: It inhibits the enzyme dihydroneopterin aldolase (DHNA), which catalyzes the conversion of This molecule to 6-hydroxymethyl-7,8-dihydropterin and glycolaldehyde. Option B: It exerts its action by binding on the benzodiazepine receptor complex and modulation of the GABABZ receptor chloride channel macromolecular complex. Option C: It is thought that this molecule acts by blocking central cholinergic receptors, and thus balancing cholinergic and dopaminergic activity in the basal ganglia. Option D: It causes the release of noradrenaline by acting on the adrenergic nerve terminals and alpha- and beta-receptors. " A 2564 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCOC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2 Question about this molecule: What is the right information about this molecule's medical effects? Option A: It blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins. Option B: It blocks the action of endogenous histamine, leading to temporary relief of the negative symptoms brought on by histamine. Option C: It can reduce symptoms through its actions on histamine receptors. Option D: It competes with free histamine for binding at HA-receptor sites. " D 3016 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3 Question about this molecule: What is the right information about this molecule's medical effects? Option A: This occurrence led to the development of novel second-generation ALK inhibitors such as this molecule to overcome crizotinib resistance. Option B: It is a diuretic drug with uric acid-lowering action which was marketed for the treatment of hypertension. Option C: This molecule exerts its actions against myasthenia gravis by competitive, reversible inhibition of acetylcholinesterase. Option D: Its actions are mediated by enhancement of gamma-aminobutyric acid activity. " D 40326 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C(C1C(=O)OCC2=CC(=CC=C2)OC3=CC=CC=C3)C=C(Cl)Cl)C Question about this molecule: What is the right information about this molecule's medical effects? Option A: It inhibits sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. Option B: It alters signal conduction in neurons by blocking the fast voltage gated sodium (Na+) channels in the neuronal cell membrane that are responsible for signal propagation. Option C: It disrupts the sodium channel current by which the polarization of the membrane is regulated. Option D: It binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. " C 54746 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@H]2[C@@H](CC3=CNC4=CC=CC2=C34)N(C1)CC=C Question about this molecule: What is the right information about this molecule's medical effects? Option A: It inhibits functioning of postsynaptic dopamine receptors. Option B: It activates glutamatergic circuits while inhibiting GABA. Option C: It is a long-acting dopamine agonist and prolactin inhibitor. Option D: It blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins. " C 5355863 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C(=C\\C(=O)OC)/OP(=O)(OC)OC Question about this molecule: What is the right information about this molecule's medical effects? Option A: It inhibits acetylcholinesterase in the nervous system of insects. Option B: It acts as an acetylcholinesterase inhibitor to control insects in a wide range of crops. Option C: This molecule exerts its actions against myasthenia gravis by competitive, reversible inhibition of acetylcholinesterase. Option D: It is non-systemic with contact and stomach action, and an acetylcholinesterase (AChE) inhibitor. " B 1993 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C[N+](C)(C)C)OC(=O)C Question about this molecule: What is the right information about this molecule's medical effects? Option A: Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization. Option B: It binds to angiotensin II type 1 (AT1) receptors, inhibiting the action of angiotensin II on vascular smooth muscle and reducing arterial blood pressure. Option C: It inhibits spinal polysynaptic afferent pathways and, to a lesser extent, monosynaptic afferent pathways. Option D: It induces bronchoconstriction through muscarinic receptors in the lungs. " D 5826 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](CC1=CC=CC=C1)N Question about this molecule: What is the right information about this molecule's medical effects? Option A: It blocks the D2 somatodendritic autoreceptor, resulting in the blockade of postsynaptic dopamine receptors in the mesolimbic system and an increased dopamine turnover. Option B: It exerts its action by binding on the benzodiazepine receptor complex and modulation of the GABABZ receptor chloride channel macromolecular complex. Option C: It causes the release of noradrenaline by acting on the adrenergic nerve terminals and alpha- and beta-receptors. Option D: It increases the activity of norepinephrine (noradrenalin) on adrenergic receptors. " C 4497 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOC Question about this molecule: What is the right information about this molecule's medical effects? Option A: It may act by blocking repetitive firing of voltage-gated sodium channels leading to a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. Option B: It stabilizes voltage-gated L-type calcium channels in vascular smooth muscle cells. Option C: It alters signal conduction in neurons by blocking the fast voltage gated sodium (Na+) channels in the neuronal cell membrane that are responsible for signal propagation. Option D: It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. " B 444031 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(C[C@@H]1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5 Question about this molecule: What is the right information about this molecule's medical effects? Option A: It inhibits spinal polysynaptic afferent pathways and, to a lesser extent, monosynaptic afferent pathways. Option B: Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization. Option C: It induces bronchoconstriction through muscarinic receptors in the lungs. Option D: It blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. " D 5656 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O Question about this molecule: What is the right information about this molecule's medical effects? Option A: Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. Option B: It works by blocking the transporter reuptake proteins for key neurotransmitters affecting mood, thereby leaving more active neurotransmitter in the synapse. Option C: It induces bronchoconstriction through muscarinic receptors in the lungs. Option D: Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization. " B 2724385 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5C[C@H]([C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)O)C)C)C)O)O Question about this molecule: What is the right information about this molecule's medical effects? Option A: Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization. Option B: It induces bronchoconstriction through muscarinic receptors in the lungs. Option C: It acts indirectly on reticular formation, whereby neuronal activity into reticular formation is reduced without affecting its intrinsic ability to activate the cerebral cortex. Option D: Increased amounts of Ca2+ are then stored in the sarcoplasmic reticulum and released by each action potential, which is unchanged by digoxin. " D 56640146 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)C1=CC(=CC(=C1OC)C2=CC3=C(C=C2)C=C(C=C3)NS(=O)(=O)C)N4C=CC(=O)NC4=O Question about this molecule: What is the right information about this molecule's medical effects? Option A: It is a non-nucleoside NS5B inhibitor which binds to the palm domain of NS5B and induces a conformational change which renders the polymerase unable to elongate viral RNA. Option B: It binds to angiotensin II type 1 (AT1) receptors, inhibiting the action of angiotensin II on vascular smooth muscle and reducing arterial blood pressure. Option C: It has three distinct pharmacological actions: (1) stimulation of presynaptic 5-HT1D receptors, (2) direct inhibition of trigeminal nuclei cell excitability via 5-HT1B/1D receptor agonism in the brainstem, and (3) vasoconstriction of meningeal, dural, cerebral or pial vessels as a result of vascular 5-HT1B receptor agonism. Option D: It is a triazole fungicide, also known as a DMI, or demethylation inhibiting fungicide due to its binding with and inhibiting the 14-alpha demethylase enzyme from demethylating a precursor to ergosterol. " A 4078 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)C Question about this molecule: What is the right information about this molecule's medical effects? Option A: It induces bronchoconstriction through muscarinic receptors in the lungs. Option B: It acts indirectly on reticular formation, whereby neuronal activity into reticular formation is reduced without affecting its intrinsic ability to activate the cerebral cortex. Option C: Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization. Option D: It binds to angiotensin II type 1 (AT1) receptors, inhibiting the action of angiotensin II on vascular smooth muscle and reducing arterial blood pressure. " B 4236 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)S(=O)CC(=O)N Question about this molecule: What is the right information about this molecule's medical effects? Option A: It inhibits beta-tubulin synthesis, inhibiting development of germ tubes and the growth of mycelia. Option B: It activates glutamatergic circuits while inhibiting GABA. Option C: Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization. Option D: It induces bronchoconstriction through muscarinic receptors in the lungs. " B 1175 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C12=C(NC(=O)N1)NC(=O)NC2=O Question about this molecule: What is the right information about this molecule's medical effects? Option A: It narrows blood vessels in the brain, stops pain signals from being sent to the brain, and stops the release of certain natural substances that cause pain, nausea, and other symptoms of migraine. Option B: When there is an excess amount in the blood, called hyperuricemia, this can lead to gout and formation of kidney stones. Option C: It blocks the effects of glutamate, a neurotransmitter in the brain that leads to neuronal excitability and excessive stimulation in Alzheimer's Disease. Option D: Dopamine-antagonizing medications such as this molecule are though to improve psychotic symptoms and states that are caused by an over-production of dopamine, such as schizophrenia, which is theorized to be caused by a hyperdopaminergic state within the limbic system of the brain. " B 11824 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C2=C(N=CN=C2N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N)C#N Question about this molecule: What is the right information about this molecule's medical effects? Option A: It blocks RNA synthesis and ribosome function, and is used mainly as a tool in biochemistry. Option B: It inhibits DNA synthesis and interacts with SH groups. Option C: Its action is driven by the competitive and reversible inhibition of the factor Xa. Option D: It induces a conformational change in the estrogen receptors (ER). " A 41693 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCC3=CC=CS3)COC Question about this molecule: What is the right information about this molecule's medical effects? Option A: It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. Option B: It may act by blocking repetitive firing of voltage-gated sodium channels leading to a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. Option C: It opens calcium-dependent inwardly rectifying potassium channels (OP1 receptor agonist). Option D: It stabilizes voltage-gated L-type calcium channels in vascular smooth muscle cells. " C 4633 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOC1=C(C=CC(=C1)C(=O)OCCN(CC)CC)N Question about this molecule: What is the right information about this molecule's medical effects? Option A: It alters signal conduction in neurons by blocking the fast voltage gated sodium (Na+) channels in the neuronal cell membrane that are responsible for signal propagation. Option B: It promotes the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys. Option C: It inhibits sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. Option D: It binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. " D 5568 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)C(F)(F)F Question about this molecule: What is the right information about this molecule's medical effects? Option A: It induces bronchoconstriction through muscarinic receptors in the lungs. Option B: It inhibits glucose reabsorption in the proximal tubule of the nephron and causes glycosuria. Option C: It mainly acts on the cells of the distal part of the nephron and the collecting tubules in the kidney. Option D: It blocks the neurotransmitter dopamine and the vagus nerve in the gastrointestinal tract. " D 25074887 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCNC(=O)N)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC3=CN=CC=C3)NC(=O)[C@@H](CC4=CC=C(C=C4)Cl)NC(=O)[C@@H](CC5=CC6=CC=CC=C6C=C5)NC(=O)C Question about this molecule: What is the right information about this molecule's medical effects? Option A: It acts by decreasing the reuptake of norepinephrine and serotonin (5-HT). Option B: It increases the activity of norepinephrine (noradrenalin) on adrenergic receptors. Option C: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option D: It blocks the effects of Gonadotropin Releasing Hormone (GnRH). " D 2812 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4 Question about this molecule: What is the right information about this molecule's medical effects? Option A: It exerts a non-genomic action by targeting important signaling molecules in vascular endothelial cells (ECs). Option B: This molecule acts by causing the arrest of cells in metaphase mitosis through its inhibition tubulin mitotic functioning. Option C: Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. Option D: It acts indirectly on reticular formation, whereby neuronal activity into reticular formation is reduced without affecting its intrinsic ability to activate the cerebral cortex. " C 40839 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)N)O)O)CC)OC)C(=O)OC)O Question about this molecule: What is the right information about this molecule's medical effects? Option A: This molecule acts by causing the arrest of cells in metaphase mitosis through its inhibition tubulin mitotic functioning. Option B: It induces bronchoconstriction through muscarinic receptors in the lungs. Option C: Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization. Option D: This occurrence led to the development of novel second-generation ALK inhibitors such as this molecule to overcome crizotinib resistance. " A 43815 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4 Question about this molecule: What is the right information about this molecule's medical effects? Option A: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option B: During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option C: It has three distinct pharmacological actions: (1) stimulation of presynaptic 5-HT1D receptors, (2) direct inhibition of trigeminal nuclei cell excitability via 5-HT1B/1D receptor agonism in the brainstem, and (3) vasoconstriction of meningeal, dural, cerebral or pial vessels as a result of vascular 5-HT1B receptor agonism. Option D: It blocks the D2 somatodendritic autoreceptor, resulting in the blockade of postsynaptic dopamine receptors in the mesolimbic system and an increased dopamine turnover. " B 43234 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC1COC(O1)(CN2C=NC=N2)C3=C(C=C(C=C3)Cl)Cl Question about this molecule: What is the right information about this molecule's medical effects? Option A: It has three distinct pharmacological actions: (1) stimulation of presynaptic 5-HT1D receptors, (2) direct inhibition of trigeminal nuclei cell excitability via 5-HT1B/1D receptor agonism in the brainstem, and (3) vasoconstriction of meningeal, dural, cerebral or pial vessels as a result of vascular 5-HT1B receptor agonism. Option B: It binds to angiotensin II type 1 (AT1) receptors, inhibiting the action of angiotensin II on vascular smooth muscle and reducing arterial blood pressure. Option C: Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization. Option D: It is a triazole fungicide, also known as a DMI, or demethylation inhibiting fungicide due to its binding with and inhibiting the 14-alpha demethylase enzyme from demethylating a precursor to ergosterol. " D 24434 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N+](=O)([O-])[O-].[K+] Question about this molecule: What is the right information about this molecule's medical effects? Option A: Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. Option B: It is a common active ingredient in toothpaste, exerting an anti-sensitivity action. Option C: It exerts a non-genomic action by targeting important signaling molecules in vascular endothelial cells (ECs). Option D: It has a broad spectrum of action, being systemic with protective and curative action. " B 3779 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(C1=CC(=C(C=C1)O)O)O Question about this molecule: What is the right information about this molecule's medical effects? Option A: It is used in cereal seed dressing and fungicidal non-mercurial seed dressing with special action against fusarium. Option B: It selectively targets mutant proteins in malignant cells, acting similarly to erlotinib. Option C: This occurrence led to the development of novel second-generation ALK inhibitors such as this molecule to overcome crizotinib resistance. Option D: The US patent from 1943 states that this compound had a wider therapeutic index and a stronger action than [adrenaline]. " D 5472 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(CC2=C1SC=C2)CC3=CC=CC=C3Cl Question about this molecule: What is the right information about this molecule's medical effects? Option A: This occurrence led to the development of novel second-generation ALK inhibitors such as this molecule to overcome crizotinib resistance. Option B: It is a prodrug that is metabolized to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Option C: Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization. Option D: It exerts its action by binding on the benzodiazepine receptor complex and modulation of the GABABZ receptor chloride channel macromolecular complex. " B 146570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCC[C@@]1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F Question about this molecule: What is the right information about this molecule's medical effects? Option A: It blocks the D2 somatodendritic autoreceptor, resulting in the blockade of postsynaptic dopamine receptors in the mesolimbic system and an increased dopamine turnover. Option B: It has three distinct pharmacological actions: (1) stimulation of presynaptic 5-HT1D receptors, (2) direct inhibition of trigeminal nuclei cell excitability via 5-HT1B/1D receptor agonism in the brainstem, and (3) vasoconstriction of meningeal, dural, cerebral or pial vessels as a result of vascular 5-HT1B receptor agonism. Option C: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option D: During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. " D 47528 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CN=C1)C(=O)NCCO[N+](=O)[O-] Question about this molecule: What is the right information about this molecule's medical effects? Option A: It may act by blocking repetitive firing of voltage-gated sodium channels leading to a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. Option B: It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. Option C: Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization. Option D: It is a dual-action potassium channel opener that relaxes vascular smooth muscle through membrane hyperpolarization via increased transmembrane potassium conductance and increased intracellular concentration of cyclic GMP. " D 3637 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=NN=C2NN Question about this molecule: What is the right information about this molecule's medical effects? Option A: It is a centrally acting sympatholytic agent and an antihypertensive agent. Option B: It is a commonly used oral antihypertensive agent that acts by inducing peripheral vasodilation. Option C: It is used in cereal seed dressing and fungicidal non-mercurial seed dressing with special action against fusarium. Option D: It selectively targets mutant proteins in malignant cells, acting similarly to erlotinib. " B 681 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1CCN)O)O Question about this molecule: What is the right information about this molecule's medical effects? Option A: It inhibits functioning of postsynaptic dopamine receptors. Option B: A family of receptors (receptors, dopamine) mediate its action. Option C: It blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins. Option D: It can reduce symptoms through its actions on histamine receptors. " B 445643 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC Question about this molecule: What is the right information about this molecule's medical effects? Option A: It is a prodrug that is metabolized to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Option B: This occurrence led to the development of novel second-generation ALK inhibitors such as this molecule to overcome crizotinib resistance. Option C: It is a thrombopoiesis stimulating dimer Fc-peptide fusion protein (peptibody) to increase platelet production through activation of the thrombopoietin receptor. Option D: It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. " D 3393 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3F Question about this molecule: What is the right information about this molecule's medical effects? Option A: It binds to angiotensin II type 1 (AT1) receptors, inhibiting the action of angiotensin II on vascular smooth muscle and reducing arterial blood pressure. Option B: Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. Option C: It induces bronchoconstriction through muscarinic receptors in the lungs. Option D: Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization. " D 1570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=S)N(C=C1)O Question about this molecule: What is the right information about this molecule's medical effects? Option A: It binds to keratin in human cells, then once it reaches the fungal site of action, it binds to fungal microtubes thus altering the fungal process of mitosis. Option B: It mediates its action by increasing the cellular levels of copper, and damaging iron-sulfur clusters of proteins essential for fungal metabolism and growth. Option C: It inhibits beta-tubulin synthesis, inhibiting development of germ tubes and the growth of mycelia. Option D: It inhibits glucose reabsorption in the proximal tubule of the nephron and causes glycosuria. " B 2131 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)CC1=CC=CC=C1Cl)CC2=CC=CC=C2Cl Question about this molecule: What is the right information about this molecule's medical effects? Option A: It induces bronchoconstriction through muscarinic receptors in the lungs. Option B: This molecule exerts its actions against myasthenia gravis by competitive, reversible inhibition of acetylcholinesterase. Option C: It inhibits spinal polysynaptic afferent pathways and, to a lesser extent, monosynaptic afferent pathways. Option D: It inhibits glucose reabsorption in the proximal tubule of the nephron and causes glycosuria. " B 119 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(=O)O)CN Question about this molecule: What is the right information about this molecule's medical effects? Option A: It blocks neuromuscular transmission. Option B: It prevents transmission of impulses along nerve fibers and at nerve endings. Option C: It acts at inhibitory synapses in the brain. Option D: It activates glutamatergic circuits while inhibiting GABA. " C 5073 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F Question about this molecule: What is the right information about this molecule's medical effects? Option A: It selectively targets mutant proteins in malignant cells, acting similarly to erlotinib. Option B: It inhibits functioning of postsynaptic dopamine receptors. Option C: It activates glutamatergic circuits while inhibiting GABA. Option D: It produces inhibitory postsynaptic potentials. " B 8612 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCOC(=O)C1=C(C=C(C=C1)N)Cl Question about this molecule: What is the right information about this molecule's medical effects? Option A: It blocks the generation and the conduction of nerve impulses. Option B: It prevents transmission of impulses along nerve fibers and at nerve endings. Option C: It acts at inhibitory synapses in the brain. Option D: It activates glutamatergic circuits while inhibiting GABA. " A 2284 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C(CC(=O)O)CN)Cl Question about this molecule: What is the right information about this molecule's medical effects? Option A: Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization. Option B: It binds to angiotensin II type 1 (AT1) receptors, inhibiting the action of angiotensin II on vascular smooth muscle and reducing arterial blood pressure. Option C: It induces bronchoconstriction through muscarinic receptors in the lungs. Option D: It inhibits spinal polysynaptic afferent pathways and, to a lesser extent, monosynaptic afferent pathways. " D 107782 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COP(=O)(O)O)O)C)O)F)C Question about this molecule: What is the right information about this molecule's medical effects? Option A: This occurrence led to the development of novel second-generation ALK inhibitors such as this molecule to overcome crizotinib resistance. Option B: It is used in cereal seed dressing and fungicidal non-mercurial seed dressing with special action against fusarium. Option C: It is a commonly used oral antihypertensive agent that acts by inducing peripheral vasodilation. Option D: It provides rapidly accessible [betamethasone] to agonize glucocorticoid receptors. " D 4189 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl Question about this molecule: What is the right information about this molecule's medical effects? Option A: It inhibits acetylcholinesterase in the nervous system of insects. Option B: It inhibits fungal CYP450 14α-lanosterol demethylase activity. Option C: It inhibits the activity of the squalene epoxidase enzyme that is essential in the formation of sterols necessary for fungal cell membranes. Option D: It inhibits fungal cell membrane synthesis. " B 3455 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F Question about this molecule: What is the right information about this molecule's medical effects? Option A: It is a long-acting dopamine agonist and prolactin inhibitor. Option B: It blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins. Option C: It is a highly selective dopamine transporter antagonist. Option D: It inhibits functioning of postsynaptic dopamine receptors. " C 122087 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C)(C(=O)CCl)NC(=O)C1=CC(=C(C(=C1)Cl)C)Cl Question about this molecule: What is the right information about this molecule's medical effects? Option A: It acts by inhibiting nuclear division. Option B: It inhibits DNA synthesis and interacts with SH groups. Option C: It blocks neuromuscular transmission. Option D: It acts by inhibition of mitochondrial respiration. " A 2268 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=S)(OC)SCN1C(=O)C2=CC=CC=C2N=N1 Question about this molecule: What is the right information about this molecule's melting point? Option A: Melting point 68 °F (20 °C) Option B: It melts at about 72-74ºC (162-165ºF) Option C: It has a melting point of 740-1785 °C. Option D: It has a melting point of 195-196 °C. " B 5816 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC[C@@H](C1=CC(=C(C=C1)O)O)O Question about this molecule: What is the right information about this molecule's melting point? Option A: Melting point 211-212 °C Option B: Melting point 175.8-186.8 °C Option C: Melting point 173-175 °C Option D: Melting point 55-157 °C " A 2256 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC1=NC(=NC(=N1)Cl)NC(C)C Question about this molecule: What is the right information about this molecule's melting point? Option A: Melting point 175.8-186.8 °C Option B: Melting point 211-212 °C Option C: Melting point 55-157 °C Option D: Melting point 173-175 °C " D 11443 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)N=C=O)N=C=O Question about this molecule: What is the right information about this molecule's melting point? Option A: Melting point 187-189 °F (86-87 °C) Option B: Melting point 68 °F (20 °C) Option C: Melting point 251.2 °F (121.8 °C) Option D: Melting point 265 °F (129-130 °C) " B 6954 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1[N+](=O)[O-])O)[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: What is the right information about this molecule's melting point? Option A: Melting point 187-189 °F (86-87 °C) Option B: Melting point 265 °F (129-130 °C) Option C: Melting point 68 °F (20 °C) Option D: Melting point 251.2 °F (121.8 °C) " D 6597 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)O)(Cl)Cl Question about this molecule: What is the right information about this molecule's melting point? Option A: Melting point 68 °F (20 °C) Option B: It melts at 49 °F Option C: It melts at 15 °C Option D: It melts at 110 °F. " B 7329 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1Cl)SC2=C(C=CC(=C2)Cl)O)O Question about this molecule: What is the right information about this molecule's melting point? Option A: Melting point 175.8-186.8 °C Option B: Melting point 55-157 °C Option C: Melting point 211-212 °C Option D: Melting point 173-175 °C " A 10377 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC1=CC(=CC(=C1)O)O Question about this molecule: What is the right information about this molecule's melting point? Option A: Melting point 147-159 °C Option B: Melting point: 102-106 °F Option C: Melting point 55-157 °C Option D: Melting point 138-140 °C " B 16666 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1CC[C@H]([C@@H](C1)O)C(C)C Question about this molecule: What is the right information about this molecule's melting point? Option A: It melts at 15 °C Option B: It melts at 110 °F. Option C: It is a solid at room temperature but melts easily in boiling water. Option D: It is solid at room temperature and melts slightly above " D 2314 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(OC2=C(O1)C(=CC=C2)OC(=O)NC)C Question about this molecule: What is the right information about this molecule's melting point? Option A: Melting point 265 °F (129-130 °C) Option B: Melting point 68 °F (20 °C) Option C: Melting point 187-189 °F (86-87 °C) Option D: Melting point 251.2 °F (121.8 °C) " A 1639 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NNC(=N1)N Question about this molecule: What is the right information about this molecule's melting point? Option A: Melting point 147-159 °C Option B: Melting point 138-140 °C Option C: Melting point 55-157 °C Option D: Melting point 173-175 °C " A 7860 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)C=O Question about this molecule: What is the right information about this molecule's melting point? Option A: It melts at 110 °F. Option B: Melting point 68 °F (20 °C) Option C: It melts at 15 °C Option D: It melts at 49 °F " C 16682804 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)O[Sn](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3 Question about this molecule: What is the right information about this molecule's melting point? Option A: Melting point 123-131 °C (253-268 °F) Option B: Melting point 187-189 °F (86-87 °C) Option C: Melting point 104-106 °F (40-41 °C) Option D: Melting point 265 °F (129-130 °C) " A 23938 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Pd] Question about this molecule: What is the right information about this molecule's melting point? Option A: It has a melting point of 195-196 °C. Option B: Melting point 68 °F (20 °C) Option C: It has the lowest melting point and is the least dense of platinum group metals Option D: It has a melting point of 740-1785 °C. " C 6518 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(CO[N+](=O)[O-])(CO[N+](=O)[O-])CO[N+](=O)[O-])O[N+](=O)[O-] Question about this molecule: What is the right information about this molecule's melting point? Option A: Melting point 147-159 °C Option B: Melting point 55-157 °C Option C: Melting point 173-175 °C Option D: Melting point 138-140 °C " D 2078 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC1=C(C(=CC=C1)CC)N(COC)C(=O)CCl Question about this molecule: What is the right information about this molecule's melting point? Option A: Melting point 265 °F (129-130 °C) Option B: Melting point 104-106 °F (40-41 °C) Option C: Melting point 187-189 °F (86-87 °C) Option D: Melting point 123-131 °C (253-268 °F) " B 5280863 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O Question about this molecule: What is the right information about this molecule's melting point? Option A: It has a melting point of 382-384 °F (194-195 °C). Option B: It has a melting point of 195-196 °C. Option C: It has a melting point of 740-1785 °C. Option D: It is a yellow crystalline solid with a melting point of 276-278 degree centigrade " D 56841936 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O Question about this molecule: What is the right information about this molecule's melting point? Option A: Melting point 68 °F (20 °C) Option B: Melting point 251.2 °F (121.8 °C) Option C: It has a melting point of 195-196 °C. Option D: It has a melting point of 740-1785 °C. " D 996 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)O Question about this molecule: What is the right information about this molecule's melting point? Option A: It melts at 49 °F Option B: Melting point 68 °F (20 °C) Option C: It melts at 15 °C Option D: It melts at 110 °F. " D 15531 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1Br)O)Br)C#N Question about this molecule: What is the right information about this molecule's melting point? Option A: Melting point 187-189 °F (86-87 °C) Option B: Melting point 104-106 °F (40-41 °C) Option C: Melting point 123-131 °C (253-268 °F) Option D: It has a melting point of 382-384 °F (194-195 °C). " D 2513 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[As](=O)(C)O Question about this molecule: What is the right information about this molecule's melting point? Option A: Melting point 251.2 °F (121.8 °C) Option B: It has a melting point of 740-1785 °C. Option C: It has a melting point of 195-196 °C. Option D: Melting point 68 °F (20 °C) " C 342 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC=C1)O Question about this molecule: What is the right information about this molecule's melting point? Option A: It is a solid at room temperature but melts easily in boiling water. Option B: It has melting points not far from room temperature. Option C: It has low melting points. Option D: It is solid at room temperature and melts slightly above " B 3893 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCC(=O)O Question about this molecule: What is the right information about this molecule's melting point? Option A: It is a solid at room temperature but melts easily in boiling water. Option B: It melts at 110 °F. Option C: It is solid at room temperature and melts slightly above Option D: It melts at 15 °C " A 16653 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCSC(=O)N1CCCCCC1 Question about this molecule: What is the right information about this molecule's melting point? Option A: It is solid at room temperature and melts slightly above Option B: It is a solid at room temperature but melts easily in boiling water. Option C: It has low melting points. Option D: It has melting points not far from room temperature. " C 297 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C Question about this molecule: What is the right information about this molecule's metabolism? Option A: It provides a rapid, simple means of semi quantitatively assessing the ongoing in situ metabolism of the methanogenic flora. Option B: In HIV-1-infected patients and in patients with Lyme neuroborreliosis, a marked rise of KYNA metabolism was seen. Option C: It is metabolized into dopamine, resulting in an increase in the levels of circulating dopamine in the blood and to various extracerebral tissues. Option D: This molecule is a prodrug that is metabolized to an active form, which blocks the ADP receptor involved in GPIIb/IIIa receptor activation leading to platelet aggregation. " A 1981 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)OCC(=O)O Question about this molecule: What is the right information about this molecule's metabolism? Option A: It is oxidized to aromatic compounds including ortho-cresol, which is not found significantly in the urine of nonexposed individuals. Option B: It is metabolized into dopamine, resulting in an increase in the levels of circulating dopamine in the blood and to various extracerebral tissues. Option C: It led to the formation of indomethacin and it kept the same side effects. Option D: In HIV-1-infected patients and in patients with Lyme neuroborreliosis, a marked rise of KYNA metabolism was seen. " C 464 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(=O)NCC(=O)O Question about this molecule: What is the right information about this molecule's metabolism? Option A: It is oxidized to aromatic compounds including ortho-cresol, which is not found significantly in the urine of nonexposed individuals. Option B: In HIV-1-infected patients and in patients with Lyme neuroborreliosis, a marked rise of KYNA metabolism was seen. Option C: It is metabolized into dopamine, resulting in an increase in the levels of circulating dopamine in the blood and to various extracerebral tissues. Option D: This molecule is a prodrug that is metabolized to an active form, which blocks the ADP receptor involved in GPIIb/IIIa receptor activation leading to platelet aggregation. " A 6274 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(NC=N1)C[C@@H](C(=O)O)N Question about this molecule: What is the right information about this molecule's metabolism? Option A: It is metabolized into dopamine, resulting in an increase in the levels of circulating dopamine in the blood and to various extracerebral tissues. Option B: Inborn errors of its metabolism exist and are marked by increased its levels in the blood. Option C: It is oxidized to aromatic compounds including ortho-cresol, which is not found significantly in the urine of nonexposed individuals. Option D: In HIV-1-infected patients and in patients with Lyme neuroborreliosis, a marked rise of KYNA metabolism was seen. " B 335 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1O Question about this molecule: What is the right information about this molecule's metabolism? Option A: It is metabolized by conjugation and oxidation. Option B: It is metabolized through conjugation, mainly sulphation and glucuronization. Option C: It is extensively metabolized by hydroxylation, hydrolysis, and glucuronidation. Option D: It is mainly metabolized by CYP3As. " A 446157 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C1=NC(=NC(=C1/C=C/[C@H](C[C@H](CC(=O)O)O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C Question about this molecule: What is the right information about this molecule's metabolism? Option A: It is metabolized by conjugation and oxidation. Option B: It has minimal metabolism via the Cytochrome P450 system. Option C: It is metabolized by the enzyme monoamine oxidase. Option D: It is metabolized to glycine by the enzyme this moleculedehydrogenase. " B 5610 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CCN)O Question about this molecule: What is the right information about this molecule's metabolism? Option A: It is metabolized by the enzyme monoamine oxidase. Option B: It is mainly metabolized by CYP3As. Option C: It is metabolized by conjugation and oxidation. Option D: It is metabolized through conjugation, mainly sulphation and glucuronization. " A 2118 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NN=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4 Question about this molecule: What is the right information about this molecule's metabolism? Option A: It is mainly metabolized by CYP3As. Option B: It is metabolized through conjugation, mainly sulphation and glucuronization. Option C: It is oxidized to aromatic compounds including ortho-cresol, which is not found significantly in the urine of nonexposed individuals. Option D: It is extensively metabolized by hydroxylation, hydrolysis, and glucuronidation. " A 1548943 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC Question about this molecule: What is the right information about this molecule's metabolism? Option A: In HIV-1-infected patients and in patients with Lyme neuroborreliosis, a marked rise of KYNA metabolism was seen. Option B: It is metabolized into dopamine, resulting in an increase in the levels of circulating dopamine in the blood and to various extracerebral tissues. Option C: This molecule is a prodrug that is metabolized to an active form, which blocks the ADP receptor involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Option D: It is considered to be metabolized by cytochrome P-450-dependent mixed-function oxidases to reactive species. " D 45375808 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3 Question about this molecule: What is the right information about this molecule's metabolism? Option A: This molecule is a prodrug that is metabolized to an active form, which blocks the ADP receptor involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Option B: It is metabolized into its active form as the antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-triphosphate. Option C: It is considered to be metabolized by cytochrome P-450-dependent mixed-function oxidases to reactive species. Option D: In HIV-1-infected patients and in patients with Lyme neuroborreliosis, a marked rise of KYNA metabolism was seen. " B 1088 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNCC(=O)O Question about this molecule: What is the right information about this molecule's metabolism? Option A: It is metabolized by conjugation and oxidation. Option B: It is metabolized by the enzyme monoamine oxidase. Option C: It is mainly metabolized by CYP3As. Option D: It is metabolized to glycine by the enzyme this moleculedehydrogenase. " D 2327 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C(=C1CNNC(=O)C(CO)N)O)O)O Question about this molecule: What is the right information about this molecule's metabolism? Option A: It is metabolized into dopamine, resulting in an increase in the levels of circulating dopamine in the blood and to various extracerebral tissues. Option B: This molecule is a prodrug that is metabolized to an active form, which blocks the ADP receptor involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Option C: In HIV-1-infected patients and in patients with Lyme neuroborreliosis, a marked rise of KYNA metabolism was seen. Option D: This molecule can be metabolized to dopamine on either side of the blood-brain barrier and is generally administered with a dopa decarboxylase inhibitor like carbidopa to prevent metabolism until after it has crossed the blood-brain barrier. " A 2879 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)O Question about this molecule: What is the right information about this molecule's metabolism? Option A: It is extensively metabolized by hydroxylation, hydrolysis, and glucuronidation. Option B: It is mainly metabolized by CYP3As. Option C: It is oxidized to aromatic compounds including ortho-cresol, which is not found significantly in the urine of nonexposed individuals. Option D: It is metabolized through conjugation, mainly sulphation and glucuronization. " D 91731 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=NC(=C1Cl)NC2=C(C=C(C(=C2[N+](=O)[O-])Cl)C(F)(F)F)[N+](=O)[O-])C(F)(F)F Question about this molecule: What is the right information about this molecule's metabolism? Option A: It is mainly metabolized by CYP3As. Option B: It is rapidly metabolised to a compound without uncoupling activity. Option C: It is metabolized by conjugation and oxidation. Option D: It is metabolized through conjugation, mainly sulphation and glucuronization. " B 5282181 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](CCCC(C)C)[C@H]1CC[C@@H]\\2[C@@]1(CCC/C2=C\\C=C/3\\C[C@H](C[C@@H](C3=C)O)O)C Question about this molecule: What is the right information about this molecule's metabolism? Option A: It is oxidized to aromatic compounds including ortho-cresol, which is not found significantly in the urine of nonexposed individuals. Option B: It is activated by the enzyme 25-hydroxylase in the liver to mediate its effects in the body. Option C: Inborn errors of its metabolism exist and are marked by increased its levels in the blood. Option D: Upon entry into the systemic circulation, the drug is partly oxidized and partly eliminated as an unchanged compound. " B 5281708 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3)O)O Question about this molecule: What is the right information about this molecule's metabolism? Option A: In HIV-1-infected patients and in patients with Lyme neuroborreliosis, a marked rise of KYNA metabolism was seen. Option B: It is oxidized to aromatic compounds including ortho-cresol, which is not found significantly in the urine of nonexposed individuals. Option C: Only approximately one-third to one-half of the population is able to metabolize it to equol. Option D: It is metabolized into dopamine, resulting in an increase in the levels of circulating dopamine in the blood and to various extracerebral tissues. " C 5161 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)C(=O)OC2=CC=CC=C2C(=O)O)O Question about this molecule: What is the right information about this molecule's metabolism? Option A: Upon entry into the systemic circulation, the drug is partly oxidized and partly eliminated as an unchanged compound. Option B: It is activated by the enzyme 25-hydroxylase in the liver to mediate its effects in the body. Option C: It undergoes rapid esterase hydrolysis in the body. Option D: Inborn errors of its metabolism exist and are marked by increased its levels in the blood. " C 5144 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCC1=CC2=C(C=C1)OCO2 Question about this molecule: What is the right information about this molecule's metabolism? Option A: In HIV-1-infected patients and in patients with Lyme neuroborreliosis, a marked rise of KYNA metabolism was seen. Option B: The metabolism of this molecule involves oxidation of the ally1 side chain and oxidation of the methylenedioxy group with subsequent cleavage to form the catechol. Option C: The metabolism of this molecule may be modulated by genetically determined polymorphic CYP2D6 activity. Option D: This molecule is a prodrug that is metabolized to an active form, which blocks the ADP receptor involved in GPIIb/IIIa receptor activation leading to platelet aggregation. " B 3366 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC(=O)NC(=C1F)N Question about this molecule: What is the right information about this molecule's metabolism? Option A: This molecule is a prodrug that is metabolized to an active form, which blocks the ADP receptor involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Option B: It is metabolized into dopamine, resulting in an increase in the levels of circulating dopamine in the blood and to various extracerebral tissues. Option C: It is oxidized to aromatic compounds including ortho-cresol, which is not found significantly in the urine of nonexposed individuals. Option D: This molecule is metabolized to 5-fluorouracil within fungal organisms. " D 6047 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1C[C@@H](C(=O)O)N)O)O Question about this molecule: What is the right information about this molecule's metabolism? Option A: This molecule can be metabolized to dopamine on either side of the blood-brain barrier and is generally administered with a dopa decarboxylase inhibitor like carbidopa to prevent metabolism until after it has crossed the blood-brain barrier. Option B: This molecule is a prodrug that is metabolized to an active form, which blocks the ADP receptor involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Option C: In HIV-1-infected patients and in patients with Lyme neuroborreliosis, a marked rise of KYNA metabolism was seen. Option D: It is metabolized into dopamine, resulting in an increase in the levels of circulating dopamine in the blood and to various extracerebral tissues. " A 998 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)CC=O Question about this molecule: What is the right information about this molecule's metabolism? Option A: This molecule is a prodrug that is metabolized to an active form, which blocks the ADP receptor involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Option B: This molecule can be metabolized to dopamine on either side of the blood-brain barrier and is generally administered with a dopa decarboxylase inhibitor like carbidopa to prevent metabolism until after it has crossed the blood-brain barrier. Option C: This molecule has a slow onset of absorption and metabolism, resulting in a longer duration of action than nitroglycerin. Option D: This molecule will eventually be hydrolyzed and oxidized to yield phenylacetic acid that will be excreted primarily in the urine in conjugated form. " D 27982 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCl)P(=O)(O)O Question about this molecule: What is the right information about this molecule's metabolism? Option A: It is oxidized to aromatic compounds including ortho-cresol, which is not found significantly in the urine of nonexposed individuals. Option B: Upon entry into the systemic circulation, the drug is partly oxidized and partly eliminated as an unchanged compound. Option C: Upon metabolism by the plant, this molecule is converted into ethylene, a potent regulator of plant growth and maturity. Option D: It is metabolized into dopamine, resulting in an increase in the levels of circulating dopamine in the blood and to various extracerebral tissues. " C 5472 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(CC2=C1SC=C2)CC3=CC=CC=C3Cl Question about this molecule: What is the right information about this molecule's metabolism? Option A: This molecule can be metabolized to dopamine on either side of the blood-brain barrier and is generally administered with a dopa decarboxylase inhibitor like carbidopa to prevent metabolism until after it has crossed the blood-brain barrier. Option B: In HIV-1-infected patients and in patients with Lyme neuroborreliosis, a marked rise of KYNA metabolism was seen. Option C: It is metabolized into dopamine, resulting in an increase in the levels of circulating dopamine in the blood and to various extracerebral tissues. Option D: This molecule is a prodrug that is metabolized to an active form, which blocks the ADP receptor involved in GPIIb/IIIa receptor activation leading to platelet aggregation. " D 6305 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)O)N Question about this molecule: What is the right information about this molecule's metabolism? Option A: This molecule can be metabolized to dopamine on either side of the blood-brain barrier and is generally administered with a dopa decarboxylase inhibitor like carbidopa to prevent metabolism until after it has crossed the blood-brain barrier. Option B: The metabolism of this molecule to serotonin requires nutrients such as vitamin B6, niacin, and glutathione. Option C: This molecule is a prodrug that is metabolized to an active form, which blocks the ADP receptor involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Option D: In HIV-1-infected patients and in patients with Lyme neuroborreliosis, a marked rise of KYNA metabolism was seen. " B 4837 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CNCCN1 Question about this molecule: What is the right information about this molecule's metabolism? Option A: It is metabolized into dopamine, resulting in an increase in the levels of circulating dopamine in the blood and to various extracerebral tissues. Option B: In HIV-1-infected patients and in patients with Lyme neuroborreliosis, a marked rise of KYNA metabolism was seen. Option C: It is oxidized to aromatic compounds including ortho-cresol, which is not found significantly in the urine of nonexposed individuals. Option D: Upon entry into the systemic circulation, the drug is partly oxidized and partly eliminated as an unchanged compound. " D 3845 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=O)C=C(N2)C(=O)O Question about this molecule: What is the right information about this molecule's metabolism? Option A: This molecule can be metabolized to dopamine on either side of the blood-brain barrier and is generally administered with a dopa decarboxylase inhibitor like carbidopa to prevent metabolism until after it has crossed the blood-brain barrier. Option B: This molecule is a prodrug that is metabolized to an active form, which blocks the ADP receptor involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Option C: It is metabolized into dopamine, resulting in an increase in the levels of circulating dopamine in the blood and to various extracerebral tissues. Option D: In HIV-1-infected patients and in patients with Lyme neuroborreliosis, a marked rise of KYNA metabolism was seen. " D 8029 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=COC=C1 Question about this molecule: What is the odor of this molecule? Option A: It has a faint odor. Option B: It has a strong odor. Option C: It has a mild odor. Option D: It has a weak odor. " B 12397 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCCCCO Question about this molecule: What is the odor of this molecule? Option A: It has a faint odor. Option B: It has a faint odor of alcohol. Option C: It has a faint odor of ammonia. Option D: It has a faint odor of bitter almonds. " B 7762 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(=O)OCC Question about this molecule: What is the odor of this molecule? Option A: It has a faint petroleum-like odor. Option B: It has a pleasant lemon-like odor. Option C: It has a pineapple-like odor. Option D: It has a lemon-like odor. " C 7498 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)CBr Question about this molecule: What is the odor of this molecule? Option A: It has an objectionable odor. Option B: It has an agreeable odor. Option C: It has an irritating odor. Option D: It has an agreeable aromatic odor. " B 8255 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=C)C Question about this molecule: What is the odor of this molecule? Option A: It has a faint odor. Option B: It has a faint fishy odor. Option C: It has a faint petroleum like odor. Option D: It has a faint petroleum-like odor. " D 8025 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC=O Question about this molecule: What is the odor of this molecule? Option A: It has a sweet pleasant odor. Option B: It has a mild pleasant odor. Option C: It has a pleasant odor. Option D: It has a faint pleasant odor. " C 135398739 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C[C@@H](O[C@@H]1CO)N2C=NC3=C2N=CNC3=O Question about this molecule: What is the odor of this molecule? Option A: It is essentially odorless. Option B: It is usually odorless. Option C: It is odorless. Option D: It is practically odorless. " C 9570092 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(/C=N/O)SC Question about this molecule: What is the odor of this molecule? Option A: It has an objectionable odor. Option B: It has an unidentifiable characteristic odor. Option C: It has an unpleasant sulfurous or musty odor. Option D: It has no characteristic odor or taste. " C 6167 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC Question about this molecule: What is the odor of this molecule? Option A: It is odorless or nearly odorless. Option B: It has a very faint aromatic or phenolic odor. Option C: It is odorless to a faint onion-like odor. Option D: It is odorless or almost odorless. " A 31246 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(=O)CCC Question about this molecule: What is the odor of this molecule? Option A: It has a faint pleasant odor. Option B: It has a mild pleasant odor. Option C: It has a pleasant odor. Option D: It has a sweet pleasant odor. " C 10907 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CC(C)(C)C Question about this molecule: What is the odor of this molecule? Option A: It has a garlic-like odor. Option B: It has a petroleum-like odor. Option C: It has a lemon-like odor. Option D: It has a pineapple-like odor. " B 13529 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(F)(F)F)(C(F)(F)F)O Question about this molecule: What is the odor of this molecule? Option A: It has an almond odor. Option B: It has an odor of gasoline. Option C: It has an odor of lemon. Option D: It has an aromatic odor. " D 5816 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC[C@@H](C1=CC(=C(C=C1)O)O)O Question about this molecule: What is the odor of this molecule? Option A: It is usually odorless. Option B: It is odorless. Option C: It is essentially odorless. Option D: It is practically odorless. " B 12901 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=S)(OC)SCN1C(=O)C2=CC=CC=C2C1=O Question about this molecule: What is the odor of this molecule? Option A: It has an offensive odor. Option B: It has an odor of gasoline. Option C: It has an odor of lemon. Option D: It has an aromatic odor. " A 10967 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(OCCl)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a strong, unpleasant odor. Option B: It has a strong unpleasant odor. Option C: It has a weak unpleasant odor. Option D: It has a slight unpleasant odor. " B 4004 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)CC(C(=O)OCC)SP(=S)(OC)OC Question about this molecule: What is the odor of this molecule? Option A: It has an unpleasant smell. Option B: It smells like garlic. Option C: It has a sweet smell. Option D: It has a distinct smell and taste. " B 8467 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC1=C(C=CC(=C1)C=O)O Question about this molecule: What is the odor of this molecule? Option A: It has a mild non-residual odor. Option B: It has a weak suffocating odor. Option C: It has a more intense vanilla odor and taste than vanillin. Option D: It has a very faint aromatic or phenolic odor. " C 6569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)C Question about this molecule: What is the odor of this molecule? Option A: It has a strong, sweet odor. Option B: It has a faint, sweet odor. Option C: It has a sharp, sweet odor. Option D: It has a sharp, strong odor. " C 1486 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1Cl)Cl)OCC(=O)O Question about this molecule: What is the odor of this molecule? Option A: It has a characteristic vinous odor. Option B: It has a characteristic odor. Option C: It has a characteristic urinary odor. Option D: It has a characteristic phenoxy odor. " D 6278 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(Cl)(Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a sweet-smelling odor. Option B: It has a pleasant odor. Option C: It has a sweet odor. Option D: It has a sweet pleasant odor. " A 6589 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C(C)C Question about this molecule: What is the odor of this molecule? Option A: It has a pineapple-like odor. Option B: It has a petroleum-like odor. Option C: It has a lemon-like odor. Option D: It has a garlic-like odor. " B 5371562 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C(=C\\C(=O)NC)/OP(=O)(OC)OC Question about this molecule: What is the odor of this molecule? Option A: It has a mild ester odor. Option B: It has a slight ester odor. Option C: It has a mild odor. Option D: It has a mild distinctive odor. " A 11443 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)N=C=O)N=C=O Question about this molecule: What is the odor of this molecule? Option A: It has a sharp, pungent odor. Option B: It has a distinct, pungent odor. Option C: It has a pungent odor. Option D: It has a pungent, irritating odor. " A 23953 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [SiH4] Question about this molecule: What is the odor of this molecule? Option A: It has a strong odor. Option B: It has a strong odor similar to apples. Option C: It has a strong repulsive odor. Option D: It has a strong odor of vinegar. " C 957 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCO Question about this molecule: What is the odor of this molecule? Option A: It has a penetrating aromatic odor. Option B: It has a penetrating and unpleasant odor. Option C: It has a penetrating unpleasant odor. Option D: It has a penetrating odor. " A 8119 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCCNCC1 Question about this molecule: What is the odor of this molecule? Option A: It has a mild ammonia odor. Option B: It has a slight ammonia-like odor. Option C: It has an ammonia-like odor. Option D: It has a mild distinctive odor. " C 6945 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)[N+](=O)[O-])Cl Question about this molecule: What is the odor of this molecule? Option A: It has an odor of gasoline. Option B: It has an almond odor. Option C: It has an aromatic odor. Option D: It has an odor of lemon. " C 6184 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC=O Question about this molecule: What is the odor of this molecule? Option A: It has a pungent odor. Option B: It has a distinct, pungent odor. Option C: It has a pungent odor of chlorine. Option D: It has a pungent, irritating odor. " A 9703 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NC(=O)C1=CC=C(C=C1)CNNC.Cl Question about this molecule: What is the odor of this molecule? Option A: It has a slight aromatic odor. Option B: It has a slight unpleasant odor. Option C: It has a slight sulfurous odor. Option D: It has a slight odor. " D 7845 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC=C Question about this molecule: What is the odor of this molecule? Option A: It has a faint petroleum-like odor. Option B: It has a pleasant lemon-like odor. Option C: It has a mild gasoline-like odor. Option D: It has a lemon-like odor. " C 8635 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)C1=CC=CC=C1N Question about this molecule: What is the odor of this molecule? Option A: It has an odor of cloves. Option B: It has an odor of vanilla beans. Option C: It has an odor of gasoline. Option D: It has an odor of grapes. " D 31260 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CCO Question about this molecule: What is the odor of this molecule? Option A: It has a faint odor of alcohol. Option B: It has a mild, choking alcohol odor. Option C: It has a faint alcohol odor. Option D: It has a faint odor. " B 700 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CO)N Question about this molecule: What is the odor of this molecule? Option A: It has an odor resembling that of ammonia. Option B: It has an odor of ammonia. Option C: It has a faint odor of ammonia. Option D: It has a weak odor of ammonia. " A 379 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCC(=O)O Question about this molecule: What is the odor of this molecule? Option A: It has a mild sweet odor. Option B: It has a mild odor. Option C: It has a mild distinctive odor. Option D: It has a mild pleasant odor. " B 6419 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)(Cl)Cl)(Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a chloroform-like odor. Option B: It has a pineapple-like odor. Option C: It has a tar-like odor. Option D: It has a phenol-like odor. " A 638014 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(CCC1)(C)C)/C=C/C(=O)C Question about this molecule: What is the odor of this molecule? Option A: It has an odor of degrading seafood. Option B: It has an odor of amine. Option C: It has an odor of cedar wood. Option D: It has an odor of anise oil. " C 656671 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]S(=O)S(=O)(=O)[O-].[Na+].[Na+] Question about this molecule: What is the odor of this molecule? Option A: It has a slight aromatic odor. Option B: It has a slight sulfurous odor. Option C: It has a slight sulfur odor. Option D: It has a slight odor. " C 6405 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C)(C)O Question about this molecule: What is the odor of this molecule? Option A: It has an odor of gasoline. Option B: It has an odor of lemon. Option C: It has an almond odor. Option D: It has an odor of camphor. " D 6277 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)[O-].CC(=O)[O-].[Co+2] Question about this molecule: What is the odor of this molecule? Option A: It has a pineapple-like odor. Option B: It has a camphor-like odor. Option C: Vinegar-like odor. Option D: It has a medicine-like odor. " C 7344 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C(C)O Question about this molecule: What is the odor of this molecule? Option A: It has a mild pleasant odor. Option B: It has a mild distinctive odor. Option C: It has a mild sweet odor. Option D: It has a mild odor. " D 9550 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=[N+]=[N-] Question about this molecule: What is the odor of this molecule? Option A: It has a musty odor. Option B: It has a fishlike odor. Option C: It has a fishy odor. Option D: It has a faint fishy odor. " A 335 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1O Question about this molecule: What is the odor of this molecule? Option A: It has a tar-like odor. Option B: It has a sulfur-like odor. Option C: It has a phenol-like odor. Option D: It has a phenolic odor. " C 8060 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCN Question about this molecule: What is the odor of this molecule? Option A: It has a mild distinctive odor. Option B: It has a slight ammonia-like odor. Option C: It has a mild ammonia odor. Option D: It has an ammonia-like odor. " D 24463 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O.O.O.O.O.[O-]S(=O)(=O)[O-].[Cu+2] Question about this molecule: What is the odor of this molecule? Option A: It is essentially odorless. Option B: It is practically odorless. Option C: It is usually odorless. Option D: It is odorless. " D 8058 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC Question about this molecule: What is the odor of this molecule? Option A: It has a disagreeable odor. Option B: It has a distinctive, disagreeable odor. Option C: It has a slightly disagreeable odor. Option D: It has an agreeable odor. " C 1045 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCN)CN Question about this molecule: What is the odor of this molecule? Option A: It has a faint odor. Option B: It has a faint pleasant odor. Option C: It has a pleasant odor. Option D: It has a foul odor. " D 7945 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)CC(C)C Question about this molecule: What is the odor of this molecule? Option A: It has a weak odor. Option B: It has a strong odor of vinegar. Option C: It has a strong odor similar to apples. Option D: It has a strong odor. " C 7367 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(Cl)(Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a penetrating odor. Option B: It has a penetrating aromatic odor. Option C: It has a penetrating and unpleasant odor. Option D: It has a penetrating unpleasant odor. " A 6560 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CO Question about this molecule: What is the odor of this molecule? Option A: It has a sweet pleasant odor. Option B: It has a faint pleasant odor. Option C: It has a pleasant odor. Option D: It has a sweet odor. " D 10903 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC Question about this molecule: What is the odor of this molecule? Option A: It has a pineapple-like odor. Option B: It has a lemon-like odor. Option C: It has a medicine-like odor. Option D: It has a pleasant lemon-like odor. " C 7997 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCOC(=O)C Question about this molecule: What is the odor of this molecule? Option A: It has a faint pleasant odor. Option B: It has a pleasant odor. Option C: It has a sweet pleasant odor. Option D: It has a mild pleasant odor. " B 22420 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CNP(=O)(OC1)N(CCCl)CCCl.O Question about this molecule: What is the odor of this molecule? Option A: It has almost no odor. Option B: It has little or no odor. Option C: It has no distinct smell. Option D: It has no odor. " B 674 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC Question about this molecule: What is the odor of this molecule? Option A: It has a sweet odor detectable by most people at a concentration of 1 part per million (1 ppm). Option B: It has a distinctive odor that is somewhat milder and sweeter than ethanol. Option C: It smells like fish at low concentrations and like ammonia at higher concentrations. Option D: It has a fishlike odor at low concentrations changing to ammonia-like odor at higher concentrations. " C 6584 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)OC Question about this molecule: What is the odor of this molecule? Option A: It has a fragrant odor. Option B: It has a mild distinctive odor. Option C: It has a mild odor. Option D: It has a mild sweet odor. " A 11487 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)NC2=CC=CC=C2 Question about this molecule: What is the odor of this molecule? Option A: It has a pleasant odor. Option B: It has a faint pleasant odor. Option C: It has a mild pleasant odor. Option D: It has a sweet pleasant odor. " A 4130 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=S)(OC)OC1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: What is the odor of this molecule? Option A: It smells like rotten eggs. Option B: It has a faint odor. Option C: It has a faint petroleum like odor. Option D: It has a faint pleasant odor. " A 8667 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCN(CC1=CC=CS1)C2=CC=CC=N2.Cl Question about this molecule: What is the odor of this molecule? Option A: It has a faint pleasant odor. Option B: It has a faint odor. Option C: It has a pleasant odor. Option D: It has a sweet pleasant odor. " B 4650 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=O)C=CC1=O Question about this molecule: What is the odor of this molecule? Option A: It has a pungent, acrid odor. Option B: It has a pungent, irritating odor. Option C: It has a distinct, pungent odor. Option D: It has a pungent odor. " B 2761171 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC1=NC=CC(=C1)C(=S)N Question about this molecule: What is the odor of this molecule? Option A: It has a faint ethereal odor. Option B: It has a faint to moderate sulfide odor. Option C: It has a sulfide-like odor. Option D: It has a mild ethereal odor. " B 6568 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C)O Question about this molecule: What is the odor of this molecule? Option A: It has an almond odor. Option B: It has an alcohol odor. Option C: It has an odor of lemon. Option D: It has an odor of gasoline. " B 1923 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC2=C(C(=C1)O)N=CC=C2 Question about this molecule: What is the odor of this molecule? Option A: It has a phenolic odor. Option B: It has a phenol-like odor. Option C: It has a sulfur-like odor. Option D: It has a tar-like odor. " A 16684434 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[Hg]SC1=CC=CC=C1C(=O)[O-].[Na+] Question about this molecule: What is the odor of this molecule? Option A: It has a slight unpleasant odor. Option B: It has a slight sulfurous odor. Option C: It has a slight aromatic odor. Option D: It has a slight odor. " D 2723949 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=S)N Question about this molecule: What is the odor of this molecule? Option A: It has a mercaptan odor. Option B: It has a sulfur-like odor. Option C: It has a slight sulfur-mercaptan odor. Option D: It has a mercaptan-like odor. " A 6366 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=C(Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a mild odor. Option B: It has a mild, sweet smell. Option C: It has a mild, pleasant odor. Option D: It has a mild, sweet odor. " B 1549517 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCNC(=S)N Question about this molecule: What is the odor of this molecule? Option A: It has a slight odor. Option B: It has a slight garlic odor. Option C: It has a slight aromatic odor. Option D: It has a slight odor of garlic. " B 261 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC=O Question about this molecule: What is the odor of this molecule? Option A: It has a pungent, irritating odor. Option B: It has a distinct, pungent odor. Option C: It has a pungent odor. Option D: It has a pungent odor of chlorine. " C 9321 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: NN Question about this molecule: What is the odor of this molecule? Option A: It has an ammonia-like odor. Option B: It has a mild ammonia odor. Option C: It has a mild distinctive odor. Option D: It has a slight ammonia-like odor. " A 7720 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(CC)CO Question about this molecule: What is the odor of this molecule? Option A: It has an odor of lemon. Option B: It has an aromatic odor. Option C: It has an almond odor. Option D: It has an odor of gasoline. " B 8172 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(COCCOCCO)O Question about this molecule: What is the odor of this molecule? Option A: It has a mild odor. Option B: It has a mild pleasant odor. Option C: It has a mild sweet odor. Option D: It has a mild distinctive odor. " A 7852 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN Question about this molecule: What is the odor of this molecule? Option A: It has a mild distinctive odor. Option B: It has a slight ammonia-like odor. Option C: It has an ammonia-like odor. Option D: It has a mild ammonia odor. " C 19707 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(=O)C(=O)C Question about this molecule: What is the odor of this molecule? Option A: It has a penetrating odor. Option B: It has a sharp penetrating odor in high concentrations. Option C: It has a penetrating aromatic odor. Option D: It has a penetrating unpleasant odor. " B 7342 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C(C)C Question about this molecule: What is the odor of this molecule? Option A: It has a fruity, aromatic odor. Option B: It has a strong fruity odor. Option C: It has a sweet fruity odor. Option D: It has a fruity odor. " A 61055 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1COCCN1CCCN Question about this molecule: What is the odor of this molecule? Option A: It has a faint, fishlike odor. Option B: It has a faint, characteristic odor. Option C: It has a faint, sweet odor. Option D: It has a strong, sweet odor. " A 1049 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=NC=C1 Question about this molecule: What is the odor of this molecule? Option A: It has an almond odor. Option B: It has an unpleasant smell. Option C: It has an unpleasant odor. Option D: It has an odor of gasoline. " B 7641 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(CC)COC(=O)CCCCC(=O)OCC(CC)CCCC Question about this molecule: What is the odor of this molecule? Option A: It has a mild distinctive odor. Option B: It has a mild sweet odor. Option C: It has a mild pleasant odor. Option D: It has a mild odor. " D 7937 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NC(=CC=C1)C Question about this molecule: What is the odor of this molecule? Option A: It has a pepper-like odor. Option B: It has a peppermint odor. Option C: It has a garlic-like odor. Option D: It has a pineapple-like odor. " B 15413 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)OC Question about this molecule: What is the odor of this molecule? Option A: It has a disagreeable odor. Option B: It has an agreeable odor. Option C: It has a slightly disagreeable odor. Option D: It has a distinctive, disagreeable odor. " D 6575 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=C(Cl)Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a heavy sweet odor. Option B: It has a mild sweet odor. Option C: It has a somewhat sweet odor. Option D: It has a sweet odor. " C 991 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OC1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: What is the odor of this molecule? Option A: It has a slight garlic odor. Option B: It has a slight odor. Option C: It has a slight odor of garlic. Option D: It has an odor of garlic. " D 6212 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)(Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a sharp, irritating odor. Option B: It has a sharp, strong odor. Option C: It has a pleasant, nonirritating odor. Option D: It has a mild, sweet odor. " C 7501 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC1=CC=CC=C1 Question about this molecule: What is the odor of this molecule? Option A: It has a mild, sweet smell. Option B: It has a distinct smell and taste. Option C: It has a sweet smell. Option D: It has an unpleasant smell. " C 6782 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)COC(=O)C1=CC=CC=C1C(=O)OCC(C)C Question about this molecule: What is the odor of this molecule? Option A: It has a slight ester odor. Option B: It has a slight unpleasant odor. Option C: It has a slight aromatic odor. Option D: It has a slight odor. " A 7902 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCO Question about this molecule: What is the odor of this molecule? Option A: It has a fishlike odor. Option B: It has a fishy odor. Option C: It has a faint, fishlike odor. Option D: It has a faint fishy odor. " A 11167 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN=C=S Question about this molecule: What is the odor of this molecule? Option A: It has a sharp, sweet odor. Option B: It has a sharp, strong odor. Option C: It has a sharp odor. Option D: It has a sharp characteristic odor. " C 6228 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C=O Question about this molecule: What is the odor of this molecule? Option A: It has a faint, fishlike odor. Option B: It has a faint petroleum like odor. Option C: It has a faint fishy odor. Option D: It has a faint petroleum-like odor. " C 7002 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC2=CC=CC=C12 Question about this molecule: What is the odor of this molecule? Option A: It has a geranium-like odor. Option B: It has a coal tar or mothball odor. Option C: It has a strong mothball-like odor. Option D: It has a sweet chloroform-like odor. " B 2969 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCC(=O)O Question about this molecule: What is the odor of this molecule? Option A: It has a sharp rancid odor. Option B: It has a sharp, sweet odor. Option C: It has a sharp, strong odor. Option D: It has a rancid odor. " D 2164 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC1(C(=O)NC(=O)NC1=O)CCC(C)C Question about this molecule: What is the odor of this molecule? Option A: It has no distinct smell. Option B: It has no odor. Option C: It has little or no odor. Option D: It has almost no odor. " B 24874 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C)N Question about this molecule: What is the odor of this molecule? Option A: It has a weak odor of ammonia. Option B: It has a strong odor of vinegar. Option C: It has an odor of ammonia. Option D: It has a faint odor of ammonia. " C 12388 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCC Question about this molecule: What is the odor of this molecule? Option A: It has a characteristic aromatic odor. Option B: It has a hydrocarbon odor. Option C: It has a chemical odor. Option D: It has a characteristic odor. " B 6101 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)S(=O)(=O)O Question about this molecule: What is the odor of this molecule? Option A: It is odorless to a faint onion-like odor. Option B: It is odorless or almost odorless. Option C: It is odorless or nearly odorless. Option D: It has a very faint aromatic or phenolic odor. " C 7289 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(CCl)O)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a mild distinctive odor. Option B: It has a faint ethereal odor. Option C: It has a mild ethereal odor. Option D: It has an ethereal odor. " D 6407 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)C(Cl)(Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a penetrating aromatic odor. Option B: It has a penetrating unpleasant odor. Option C: It has a penetrating and unpleasant odor. Option D: It has a penetrating odor. " D 8154 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCCCCC[N+](C)(C)C.[Cl-] Question about this molecule: What is the odor of this molecule? Option A: It has an odor of degrading seafood. Option B: It has an odor of pears. Option C: It has an odor of amine. Option D: It has an odor of rubbing alcohol. " D 6397 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[Si](C)(C)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a distinct, pungent odor. Option B: It has a pungent, irritating odor. Option C: It has a pungent odor. Option D: It has a pungent odor of chlorine. " C 6028 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=C(C(=C1Cl)Cl)Cl)O)Cl Question about this molecule: What is the odor of this molecule? Option A: Strong odor. Option B: Strong irritating odor Option C: Strong odor of ammonia Option D: No odor. " A 31268 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCNC1 Question about this molecule: What is the odor of this molecule? Option A: It has a mild distinctive odor. Option B: It has a mild ammonia odor. Option C: It has a slight ammonia-like odor. Option D: It has an ammonia-like odor. " D 6629 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C1=CC=CC=C1)OO Question about this molecule: What is the odor of this molecule? Option A: It has a sharp, sweet odor. Option B: It has a sharp, irritating odor. Option C: It has a strong, sweet odor. Option D: It has a sharp, strong odor. " B 4096 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=O)(N)SC Question about this molecule: What is the odor of this molecule? Option A: It has a pungent odor. Option B: It has a pungent odor of chlorine. Option C: It has a distinct, pungent odor. Option D: It has a pungent, irritating odor. " A 7175 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCOC(=O)C1=CC=C(C=C1)O Question about this molecule: What is the odor of this molecule? Option A: Odorless or faintly aromatic odor Option B: Odorless or with a slight odor. Option C: Odorless or faint aromatic odor. Option D: Odorless or with a faint odor. " C 8857 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C Question about this molecule: What is the odor of this molecule? Option A: It has a sweet fruity odor. Option B: It has a fruity, aromatic odor. Option C: It has a fruity odor. Option D: It has a strong fruity odor. " C 8076 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOCCO Question about this molecule: What is the odor of this molecule? Option A: Nearly odorless. Option B: Fishlike odor Option C: Mustard-like odor Option D: Petroleum-like odor " A 2756 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(N=CN1)CSCCNC(=NC)NC#N Question about this molecule: What is the odor of this molecule? Option A: It has a slight odor. Option B: It has a slight sulfur-mercaptan odor. Option C: It has a slight sulfur odor. Option D: It has a slight sulfurous odor. " B 16666 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1CC[C@H]([C@@H](C1)O)C(C)C Question about this molecule: What is the odor of this molecule? Option A: It has a pineapple-like odor. Option B: It has a garlic-like odor. Option C: It has a pepper-like odor. Option D: It has a peppermint odor. " D 7967 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(=O)CC1 Question about this molecule: What is the odor of this molecule? Option A: It has a mild pleasant odor. Option B: It has a pleasant odor. Option C: It has a sweet pleasant odor. Option D: It has a faint pleasant odor. " B 853433 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C=C/C1=CC(=C(C=C1)O)OC Question about this molecule: What is the odor of this molecule? Option A: It has a sweet odor. Option B: It has a spice-clove odor. Option C: It has a sweet pleasant odor. Option D: It has a sweet-smelling odor. " B 5976 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)N Question about this molecule: What is the odor of this molecule? Option A: It has an ammonia-like odor. Option B: It has a mild ammonia odor. Option C: It has a slight ammonia-like odor. Option D: It has a mild distinctive odor. " A 8038 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)COC(=O)C Question about this molecule: What is the odor of this molecule? Option A: It has a strong fruity odor. Option B: It has a fruity, aromatic odor. Option C: It has a fruity odor. Option D: It has a sweet fruity odor. " C 24726 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(/C=C/Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a mild, sweet smell. Option B: It has a sweet smell. Option C: It has a distinct smell and taste. Option D: It has an unpleasant smell. " B 460612 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C[C@@H](C(=O)O)N)N(CCCl)CCCl Question about this molecule: What is the odor of this molecule? Option A: Odorless or with a faint odor. Option B: Odorless or faintly aromatic odor Option C: Odorless or with a slight odor. Option D: Odorless or faint aromatic odor. " A 3346 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CC(=C1)OP(=S)(OC)OC)SC Question about this molecule: What is the odor of this molecule? Option A: It has a slight garlic odor. Option B: It has a slight odor of garlic. Option C: It has a slight aromatic odor. Option D: It has a slight odor. " B 3039 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=O)(OC)OC=C(Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: It has an almond odor. Option B: It has an odor of lemon. Option C: It has an aromatic odor. Option D: It has an odor of gasoline. " C 31241 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(CC)C=O Question about this molecule: What is the odor of this molecule? Option A: It has a mild distinctive odor. Option B: It has a mild odor. Option C: It has a mild pleasant odor. Option D: It has a mild sweet odor. " B 8028 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCOC1 Question about this molecule: What is the odor of this molecule? Option A: It has a faint ethereal odor. Option B: It has a mild distinctive odor. Option C: It has an ethereal odor. Option D: It has a mild ethereal odor. " C 11883 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=C(C=C1)[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: What is the odor of this molecule? Option A: It has a slight unpleasant odor. Option B: It has a slight odor. Option C: It has a slight aromatic odor. Option D: It has a slight sulfurous odor. " B 995 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC3=CC=CC=C32 Question about this molecule: What is the odor of this molecule? Option A: It has a faint aromatic odor. Option B: It has a faint pleasant odor. Option C: It has a faint odor. Option D: It has a faint petroleum like odor. " A 8252 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC=C Question about this molecule: What is the odor of this molecule? Option A: It has a faint odor. Option B: It has a faint petroleum-like odor. Option C: It has a faint petroleum like odor. Option D: It has a faint fishy odor. " C 944 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N+](=O)(O)[O-] Question about this molecule: What is the odor of this molecule? Option A: It has a pungent choking odor. Option B: It has a suffocating odor. Option C: It has a weak suffocating odor. Option D: It has a suffocating pungent odor. " B 3598 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl Question about this molecule: What is the odor of this molecule? Option A: It is usually odorless. Option B: It is essentially odorless. Option C: It is practically odorless. Option D: It is odorless. " D 8418 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C=C3C=CC=CC3=CC2=C1 Question about this molecule: What is the odor of this molecule? Option A: It has a weak odor. Option B: It has a weak medicine odor. Option C: It has a weak aromatic odor. Option D: It has a strong odor. " C 947 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: N#N Question about this molecule: What is the odor of this molecule? Option A: It is practically odorless. Option B: It is odorless. Option C: It is usually odorless. Option D: It is essentially odorless. " B 7837 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=C)C(=O)OCC1CO1 Question about this molecule: What is the odor of this molecule? Option A: It has a sweet fruity odor. Option B: It has a fruity odor. Option C: It has a strong fruity odor. Option D: It has a fruity, aromatic odor. " B 6338 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCl Question about this molecule: What is the odor of this molecule? Option A: It has a mild pleasant odor. Option B: It has a mild odor. Option C: It has a mild, pleasant odor. Option D: It has a mild, sweet odor. " D 7000 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC=CC=C1N Question about this molecule: What is the odor of this molecule? Option A: It has an amine (fishy) odor. Option B: It has an odor of amine. Option C: It has an odor of rubbing alcohol. Option D: It has an odor of pears. " A 31373 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=C(Cl)Cl)(Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a sweet odor detectable by most people at a concentration of 1 part per million (1 ppm). Option B: It has a distinctive odor that is somewhat milder and sweeter than ethanol. Option C: It has a fishlike odor at low concentrations changing to ammonia-like odor at higher concentrations. Option D: It is odorless when pure; technical grade has a slightly pungent odor. " A 4790 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)SCSCC Question about this molecule: What is the odor of this molecule? Option A: It has an objectionable odor. Option B: It has an agreeable odor. Option C: It has an irritating odor. Option D: It has an agreeable aromatic odor. " A 8109 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOCCCO Question about this molecule: What is the odor of this molecule? Option A: Mild odor Option B: Mild, sweet odor Option C: Mild to moderately strong odor Option D: Mild pleasant odor " A 4133 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)C1=CC=CC=C1O Question about this molecule: What is the odor of this molecule? Option A: Strong odor of ammonia Option B: Strong odor. Option C: Strong irritating odor Option D: Wintergreen odor " D 7583 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)OC2=CC=CC=C2 Question about this molecule: What is the odor of this molecule? Option A: Mild pleasant odor Option B: Mild odor Option C: Mild to moderately strong odor Option D: Mild, sweet odor " A 757 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)O)O Question about this molecule: What is the odor of this molecule? Option A: It is practically odorless. Option B: It is essentially odorless. Option C: It is odorless. Option D: It is usually odorless. " C 11 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCl)Cl Question about this molecule: What is the odor of this molecule? Option A: Pleasant odor Option B: Petroleum-like odor Option C: Pleasant smell Option D: Fishlike odor " C 10039 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)=S Question about this molecule: What is the odor of this molecule? Option A: Distinct sulfide odor Option B: It has a mild ethereal odor. Option C: It has a faint to moderate sulfide odor. Option D: It has a sulfide-like odor. " A 949 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C1=CC=CC=C1 Question about this molecule: What is the odor of this molecule? Option A: Sweet fat-like odor Option B: Petroleum-like odor Option C: Fishlike odor Option D: Mustard-like odor " C 1119 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=S=O Question about this molecule: What is the odor of this molecule? Option A: Irritating odor Option B: Pungent odor Option C: Weak sour odor Option D: Pungent burning sulfur odor " B 8193 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCO Question about this molecule: What is the odor of this molecule? Option A: Fishlike odor Option B: Mustard-like odor Option C: Floral odor Option D: Petroleum-like odor " C 2724247 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[As](=O)(C)[O-].[Na+] Question about this molecule: What is the odor of this molecule? Option A: Slight odor Option B: Slightly sweet odor Option C: It is usually odorless. Option D: It is practically odorless. " A 8371 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=C(C(=O)C(=C(C1=O)Cl)Cl)Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: Slight odor Option B: It is usually odorless. Option C: Slightly sweet odor Option D: It is practically odorless. " A 7858 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCO Question about this molecule: What is the odor of this molecule? Option A: Mustard-like odor Option B: Fishlike odor Option C: Sweet fat-like odor Option D: Petroleum-like odor " A 1068 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CSC Question about this molecule: What is the odor of this molecule? Option A: Agreeable odor Option B: It has a disagreeable odor. Option C: It has a distinctive, disagreeable odor. Option D: Disagreeable odor " D 8113 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CO)NCCO Question about this molecule: What is the odor of this molecule? Option A: It has an ammonia-like odor. Option B: It has a mild ammonia odor. Option C: It has a slight ammonia-like odor. Option D: Rotten fish or ammonia odor " D 7860 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)C=O Question about this molecule: What is the odor of this molecule? Option A: Mustard-like odor Option B: Fishlike odor Option C: Slightly sweet odor Option D: Weak sour odor " D 7865 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC=O Question about this molecule: What is the odor of this molecule? Option A: Disagreeable odor Option B: It has a disagreeable odor. Option C: It has a distinctive, disagreeable odor. Option D: Agreeable odor " D 7430 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1Cl)N)Cl)[N+](=O)[O-] Question about this molecule: What is the odor of this molecule? Option A: Mild pleasant odor Option B: Disagreeable odor Option C: Aniline odor Option D: Agreeable odor " C 8175 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCC=O Question about this molecule: What is the odor of this molecule? Option A: Pleasant smell Option B: Pleasant odor Option C: Fishlike odor Option D: Petroleum-like odor " B 22386 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(C)O Question about this molecule: What is the odor of this molecule? Option A: Strong irritating odor Option B: Strong odor. Option C: No odor. Option D: Strong odor of ammonia " B 6363 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)N Question about this molecule: What is the odor of this molecule? Option A: Ammonia-like odor Option B: Fishlike odor Option C: Petroleum-like odor Option D: Mustard-like odor " A 6558 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CN Question about this molecule: What is the odor of this molecule? Option A: It has a faint, fishlike odor. Option B: It has a faint fishy odor. Option C: It has a fishlike odor. Option D: It has a fishy odor. " C 4944 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)OC1=CC=CC=C1OC(=O)NC Question about this molecule: What is the odor of this molecule? Option A: It has a strong, sweet odor. Option B: It has a faint, characteristic odor. Option C: It has a faint, sweet odor. Option D: It has a sharp, sweet odor. " B 30318 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=[Os](=O)(=O)=O Question about this molecule: What is the odor of this molecule? Option A: It has a pungent odor. Option B: It has a pungent odor of chlorine. Option C: It has a pungent, irritating odor. Option D: It has a distinct, pungent odor. " B 1732 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CC(=C1)O)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a sulfur-like odor. Option B: It has a tar-like odor. Option C: It has a phenol-like odor. Option D: It has a phenolic odor. " D 3385 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=O)NC(=O)N1)F Question about this molecule: What is the odor of this molecule? Option A: It is essentially odorless. Option B: It is odorless. Option C: It is usually odorless. Option D: It is practically odorless. " D 7802 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(=O)CC Question about this molecule: What is the odor of this molecule? Option A: It has a fruity odor. Option B: It has a strong fruity odor. Option C: It has a mild fruity odor. Option D: It has a sweet fruity odor. " C 2730 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OC1=NC(=C(C=C1Cl)Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a strong odor. Option B: It has a mild odor. Option C: It has a weak odor. Option D: It has a faint odor. " A 8456 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)C1=C(C=CC(=C1)OC)O Question about this molecule: What is the odor of this molecule? Option A: It has an odor of gasoline. Option B: It has an almond odor. Option C: It has an aromatic odor. Option D: It has an odor of lemon. " C 2519 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C=NC2=C1C(=O)N(C(=O)N2C)C Question about this molecule: What is the odor of this molecule? Option A: It is usually odorless. Option B: It is practically odorless. Option C: It is essentially odorless. Option D: It is odorless. " D 440917 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC[C@@H](CC1)C(=C)C Question about this molecule: What is the odor of this molecule? Option A: It has a lemon-like odor. Option B: It has a pleasant lemon-like odor. Option C: It has a pineapple-like odor. Option D: It has a faint petroleum-like odor. " B 527 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC=O Question about this molecule: What is the odor of this molecule? Option A: It has a fruity, pleasant odor. Option B: It has an overpowering fruity-like odor. Option C: It has a fruity, aromatic odor. Option D: It has a fruity or spicy odor. " B 7302 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC(=O)OC1 Question about this molecule: What is the odor of this molecule? Option A: It has a sweet pleasant odor. Option B: It has a faint pleasant odor. Option C: It has a pleasant odor. Option D: It has a mild pleasant odor. " C 12021 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)OC Question about this molecule: What is the odor of this molecule? Option A: It has a pleasant odor. Option B: It has a faint pleasant odor. Option C: It has a sweet pleasant odor. Option D: It has a mild pleasant odor. " A 3102 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(=O)C2=CC=CC=C2 Question about this molecule: What is the odor of this molecule? Option A: It has a mild fruity odor. Option B: It has a fruity odor. Option C: It has a fruity, aromatic odor. Option D: It has a flowery odor. " D 8094 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCC(=O)O Question about this molecule: What is the odor of this molecule? Option A: It has a distinct, pungent odor. Option B: It has a pungent odor of chlorine. Option C: It has a pungent, irritating odor. Option D: It has a pungent odor. " D 2879 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)O Question about this molecule: What is the odor of this molecule? Option A: It has a phenol-like odor. Option B: It has a tar-like odor. Option C: It has a sulfur-like odor. Option D: It has a phenolic odor. " B 10850 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCC(=O)OCC(COC(=O)CCCCCCC)OC(=O)CCCCCCC Question about this molecule: What is the odor of this molecule? Option A: It is usually odorless. Option B: It is practically odorless. Option C: It is odorless. Option D: It is essentially odorless. " C 1031 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCO Question about this molecule: What is the odor of this molecule? Option A: It has an odor of rubbing alcohol. Option B: It has a sharp musty odor like rubbing alcohol. Option C: It has a faint odor of alcohol. Option D: It has a faint alcohol odor. " B 7700 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCC1=CC=C(C=C1)OCCO Question about this molecule: What is the odor of this molecule? Option A: It has a sweet pleasant odor. Option B: It has a faint pleasant odor. Option C: It has a mild pleasant odor. Option D: It has a pleasant odor. " D 638072 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC/C(=C/CC/C(=C/CC/C=C(/CC/C=C(/CCC=C(C)C)\\C)\\C)/C)/C)C Question about this molecule: What is the odor of this molecule? Option A: It has a faint odor. Option B: It has a faint pleasant odor. Option C: It has a sweet pleasant odor. Option D: It has a pleasant odor. " A 445639 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCC/C=C\\CCCCCCCC(=O)O Question about this molecule: What is the odor of this molecule? Option A: It has a mild odor. Option B: It has a mild pleasant odor. Option C: It has a mild distinctive odor. Option D: It has a mild sweet odor. " A 7463 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)C(C)C Question about this molecule: What is the odor of this molecule? Option A: It has a mild odor. Option B: It has a mild, pleasant odor. Option C: It has a mild pleasant odor. Option D: It has a mild, sweet odor. " C 10430 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CC(=O)O Question about this molecule: What is the odor of this molecule? Option A: It has a penetrating odor. Option B: It has a penetrating aromatic odor. Option C: It has a penetrating and unpleasant odor. Option D: It has a penetrating unpleasant odor. " A 19395 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OP(=S)(OCC)OCC Question about this molecule: What is the odor of this molecule? Option A: It has an odor of garlic. Option B: It has a slight garlic odor. Option C: It has a slight odor of garlic. Option D: It has a slight odor. " A 24588 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Be+2].[Cl-].[Cl-] Question about this molecule: What is the odor of this molecule? Option A: It has a sharp odor. Option B: It has a sharp, sweet odor. Option C: It has a sharp characteristic odor. Option D: It has a sharp, strong odor. " A 244 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)CO Question about this molecule: What is the odor of this molecule? Option A: It has a faint pleasant odor. Option B: It has a pleasant odor. Option C: It has a sweet pleasant odor. Option D: It has a mild pleasant odor. " B 31236 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)OCCO Question about this molecule: What is the odor of this molecule? Option A: It has a faint pleasant odor. Option B: It has a sweet pleasant odor. Option C: It has a mild pleasant odor. Option D: It has a pleasant odor. " D 8146 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOCCOCCO Question about this molecule: What is the odor of this molecule? Option A: It has a mild pleasant odor. Option B: It has a mild odor. Option C: It has a mild, sweet odor. Option D: It has a mild, pleasant odor. " A 6720 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=C(C(=C(C(=C1Cl)Cl)Cl)Cl)Cl)[N+](=O)[O-] Question about this molecule: What is the odor of this molecule? Option A: It has a fishlike odor. Option B: It has a faint fishy odor. Option C: It has a musty odor. Option D: It has a fishy odor. " C 948 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N-]=[N+]=O Question about this molecule: What is the odor of this molecule? Option A: It is odorless to sweet. Option B: It is sweet-smelling. Option C: It is usually odorless. Option D: It is odorless. " B 590836 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCC(C)C Question about this molecule: What is the odor of this molecule? Option A: It has a slight ester odor. Option B: It has a slight odor. Option C: It has a slight aromatic odor. Option D: It has a slight unpleasant odor. " A 4 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CN)O Question about this molecule: What is the odor of this molecule? Option A: It has a slight unpleasant odor. Option B: It has a slight ammonia-like odor. Option C: It has a slight aromatic odor. Option D: It has a slight odor. " B 323 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC(=O)O2 Question about this molecule: What is the odor of this molecule? Option A: It has a fragrant odor. Option B: It has a pleasant fragrant vanilla odor. Option C: It has a mild odor. Option D: It has a mild distinctive odor. " B 7918 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)OC(=O)C Question about this molecule: What is the odor of this molecule? Option A: It has a strong odor. Option B: It has a strong odor of vinegar. Option C: It has a weak odor. Option D: It has a strong odor similar to apples. " B 6 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])Cl Question about this molecule: What is the odor of this molecule? Option A: It has an almond odor. Option B: It has an odor of lemon. Option C: It has an aromatic odor. Option D: It has an odor of gasoline. " A 7239 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a faint pleasant odor. Option B: It has a pleasant odor. Option C: It has a mild pleasant odor. Option D: It has a sweet pleasant odor. " B 13190 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCC=C Question about this molecule: What is the odor of this molecule? Option A: It has a mild odor. Option B: It has a mild pleasant odor. Option C: It has a mild sweet odor. Option D: It has a mild distinctive odor. " A 1549026 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC/C(=C/COC(=O)C)/C)C Question about this molecule: What is the odor of this molecule? Option A: It has an odor of lemon. Option B: It has an odor of chlorine. Option C: It has an odor of gasoline. Option D: It has an odor of lavender. " D 6574 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a sweet-smelling odor. Option B: It has a sweet odor. Option C: It has a pleasant odor. Option D: It has a sweet pleasant odor. " A 2727 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a slight sulfurous odor. Option B: It has a slight unpleasant odor. Option C: It has a slight odor. Option D: It has a slight aromatic odor. " C 38779 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCSP(=O)(OCC)OC1=C(C=C(C=C1)Br)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a lemon-like odor. Option B: It has a garlic-like odor. Option C: It has a pineapple-like odor. Option D: It has a pepper-like odor. " B 887 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CO Question about this molecule: What is the odor of this molecule? Option A: It has a fishlike odor at low concentrations changing to ammonia-like odor at higher concentrations. Option B: It is odorless when pure; technical grade has a slightly pungent odor. Option C: It has a pungent mercaptan-like odor. Option D: It has a distinctive odor that is somewhat milder and sweeter than ethanol. " D 241 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=CC=C1 Question about this molecule: What is the odor of this molecule? Option A: It has a faint pleasant odor. Option B: It has a sweet odor. Option C: It has a sweet pleasant odor. Option D: It has a pleasant odor. " B 1727 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CN=CC=C1N Question about this molecule: What is the odor of this molecule? Option A: It has little or no odor. Option B: It has almost no odor. Option C: It has no odor. Option D: It has no distinct smell. " C 6590 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C(=O)O Question about this molecule: What is the odor of this molecule? Option A: It has a faint odor of bitter almonds. Option B: It has a faint odor of alcohol. Option C: It has a light odor of rancid butter. Option D: It has a strong odor of vinegar. " C 5281 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCCCCCCC(=O)O Question about this molecule: What is the odor of this molecule? Option A: It has a mild pleasant odor. Option B: It has a mild sweet odor. Option C: It has a mild distinctive odor. Option D: It has a mild odor. " D 8209 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCCCO Question about this molecule: What is the odor of this molecule? Option A: It has a faint odor. Option B: It has a faint alcohol odor. Option C: It has a faint odor of alcohol. Option D: It has a faint odor of bitter almonds. " B 7954 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=NC(=NC(=N1)Cl)Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a pungent odor. Option B: It has a pungent odor of chlorine. Option C: It has a pungent, irritating odor. Option D: It has a distinct, pungent odor. " A 7635 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(CC)COC(=O)C Question about this molecule: What is the odor of this molecule? Option A: It has a fruity odor. Option B: It has a fruity, aromatic odor. Option C: It has a fruity, pleasant odor. Option D: It has a fruity or spicy odor. " C 6544 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=O)CC(C1)(C)C Question about this molecule: What is the odor of this molecule? Option A: It has a pepper-like odor. Option B: It has a camphor-like odor. Option C: It has a tar-like odor. Option D: It has a pineapple-like odor. " B 15415 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)CC(C(=O)OCC)SP(=O)(OC)OC Question about this molecule: What is the odor of this molecule? Option A: It has a slight unpleasant odor. Option B: It has a strong, unpleasant odor. Option C: It has a strong unpleasant odor. Option D: It has a weak unpleasant odor. " D 3118 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)SCCSCC Question about this molecule: What is the odor of this molecule? Option A: It has an unidentifiable characteristic odor. Option B: It has an agreeable aromatic odor. Option C: It has an agreeable odor. Option D: It has an objectionable odor. " A 702 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCO Question about this molecule: What is the odor of this molecule? Option A: It has a characteristic vinous odor. Option B: It has a characteristic odor. Option C: It has a characteristic urinary odor. Option D: It has a characteristic aromatic odor. " A 2406 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1SC2=C(C(=CC(=C2)Cl)Cl)O)O)Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a mild non-residual odor. Option B: It has a more intense vanilla odor and taste than vanillin. Option C: It has a very faint aromatic or phenolic odor. Option D: It has a weak suffocating odor. " C 6354 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CO1 Question about this molecule: What is the odor of this molecule? Option A: It has a somewhat sweet odor. Option B: It has a mild sweet odor. Option C: It has a sweet odor. Option D: It has a heavy sweet odor. " A 7047 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC=N2 Question about this molecule: What is the odor of this molecule? Option A: It has a faint odor. Option B: It has a weak odor. Option C: It has a strong odor. Option D: It has a mild odor. " C 31276 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CCOC(=O)C Question about this molecule: What is the odor of this molecule? Option A: It has a sweet odor. Option B: It has a bitter almond odor. Option C: It has a sweet-smelling odor. Option D: It has a banana odor. " D 7847 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC=O Question about this molecule: What is the odor of this molecule? Option A: It has an agreeable odor. Option B: It has a distinctive, disagreeable odor. Option C: It has a slightly disagreeable odor. Option D: It has a disagreeable odor. " D 7362 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=COC(=C1)C=O Question about this molecule: What is the odor of this molecule? Option A: It has a penetrating and unpleasant odor. Option B: It has a penetrating unpleasant odor. Option C: It has a penetrating odor. Option D: It has a penetrating aromatic odor. " C 4173 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NC=C(N1CCO)[N+](=O)[O-] Question about this molecule: What is the odor of this molecule? Option A: It has a slight odor. Option B: It has a slight aromatic odor. Option C: It has a slight unpleasant odor. Option D: It has a slight sulfurous odor. " A 7854 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC#N Question about this molecule: What is the odor of this molecule? Option A: It has an agreeable aromatic odor. Option B: It has an ether-like odor. Option C: It has an agreeable odor. Option D: It has an agreeable ether-like odor. " B 2708 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl Question about this molecule: What is the odor of this molecule? Option A: It has a slight aromatic odor. Option B: It has a slight odor. Option C: It has a slight sulfurous odor. Option D: It has a slight unpleasant odor. " B 7849 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CBr)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a sweet chloroform-like odor. Option B: It has an irritating chloroform-like odor. Option C: It has a geranium-like odor. Option D: It has a chloroform-like odor. " A 13387 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CCCC1=O Question about this molecule: What is the odor of this molecule? Option A: It has a mild, pleasant odor. Option B: It has a ""fishlike"" odor. Option C: It has a faint, fishlike odor. Option D: It has a mild, sweet odor. " B 441071 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN2CC3=CCO[C@H]4CC(=O)N5[C@H]6[C@H]4[C@H]3C[C@H]2[C@@]61C7=CC=CC=C75 Question about this molecule: What is the odor of this molecule? Option A: It has no odor. Option B: It has no distinct smell. Option C: It has little or no odor. Option D: It has almost no odor. " A 977 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=O Question about this molecule: What is the odor of this molecule? Option A: It is usually odorless. Option B: It is odorless. Option C: It is essentially odorless. Option D: It is practically odorless. " B 637563 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C=C/C1=CC=C(C=C1)OC Question about this molecule: What is the odor of this molecule? Option A: It has an odor of anise oil. Option B: It has an odor of degrading seafood. Option C: It has an odor of ammonia. Option D: It has an odor of amine. " A 13381 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCC=C Question about this molecule: What is the odor of this molecule? Option A: It has a faint pleasant odor. Option B: It has a sweet pleasant odor. Option C: It has a pleasant odor. Option D: It has a mild pleasant odor. " C 15965 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=C(C(=NC(=C1Cl)Cl)C(=O)O)Cl)N Question about this molecule: What is the odor of this molecule? Option A: It has an odor of gasoline. Option B: It has an odor of lemon. Option C: It has an aromatic odor. Option D: It has an odor of chlorine. " D 2723601 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC2=C(N1)C(=S)N=C(N2)N Question about this molecule: What is the odor of this molecule? Option A: It is odorless or almost odorless. Option B: It is odorless or nearly odorless. Option C: It has a very faint aromatic or phenolic odor. Option D: It is odorless to a faint onion-like odor. " A 3562 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(F)(F)F)(Cl)Br Question about this molecule: What is the odor of this molecule? Option A: It has a geranium-like odor. Option B: It has a sweet chloroform-like odor. Option C: It has an irritating chloroform-like odor. Option D: It has a chloroform-like odor. " B 23969 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [AsH3] Question about this molecule: What is the odor of this molecule? Option A: It has a pepper-like odor. Option B: It has a pineapple-like odor. Option C: It has a garlic-like odor. Option D: It has a garlic-like or fishy odor. " D 3032297 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CNC(=S)[S-])NC(=S)[S-].[Na+].[Na+] Question about this molecule: What is the odor of this molecule? Option A: It has a slight sulfurous odor. Option B: It has a slight unpleasant odor. Option C: It has a slight aromatic odor. Option D: It has a slight odor. " D 9032 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C-]#N.[K+] Question about this molecule: What is the odor of this molecule? Option A: It has a faint odor of ammonia. Option B: It has a faint odor of bitter almonds. Option C: It has a faint odor. Option D: It has a faint odor of alcohol. " B 7577 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CC2=CC=C(C=C2)N)N Question about this molecule: What is the odor of this molecule? Option A: Strong irritating odor Option B: Faint odor Option C: Faint petroleum-like odor Option D: Strong odor. " B 6360 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C Question about this molecule: What is the odor of this molecule? Option A: Strong irritating odor Option B: Faint petroleum-like odor Option C: Strong odor. Option D: Faint odor " B 31253 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCCC(=C)C=C)C Question about this molecule: What is the odor of this molecule? Option A: Petroleum-like odor Option B: Fishlike odor Option C: Pleasant smell Option D: Pleasant odor " D 24404 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: P Question about this molecule: What is the odor of this molecule? Option A: Odor of fingernail polish Option B: Odor of household bleach Option C: Odor of garlic or decaying fish Option D: Odor of ammonia " C 784 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OO Question about this molecule: What is the odor of this molecule? Option A: It has a pungent odor. Option B: It has a pungent, irritating odor. Option C: It has a distinct, pungent odor. Option D: Slightly pungent, irritating odor " D 7504 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)CN Question about this molecule: What is the odor of this molecule? Option A: Strong odor of ammonia Option B: No odor. Option C: Strong odor. Option D: Strong irritating odor " A 7657 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)COCC2=CC=CC=C2 Question about this molecule: What is the odor of this molecule? Option A: Mild odor Option B: Mild pleasant odor Option C: Mild, sweet odor Option D: Mild to moderately strong odor " A 7895 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(=O)C Question about this molecule: What is the odor of this molecule? Option A: Odor of garlic or decaying fish Option B: Odor of ammonia Option C: Odor of household bleach Option D: Odor of fingernail polish " D 7368 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(F)(F)F Question about this molecule: What is the odor of this molecule? Option A: Petroleum-like odor Option B: Aromatic odor Option C: Fishlike odor Option D: Mustard-like odor " B 23665760 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]Cl.[Na+] Question about this molecule: What is the odor of this molecule? Option A: Odor of fingernail polish Option B: Odor of household bleach Option C: Odor of garlic or decaying fish Option D: Odor of ammonia " B 9253 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCCC1 Question about this molecule: What is the odor of this molecule? Option A: Sweet fat-like odor Option B: Petroleum-like odor Option C: Fishlike odor Option D: Mustard-like odor " B 31289 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCC=O Question about this molecule: What is the odor of this molecule? Option A: Fishlike odor Option B: Mustard-like odor Option C: Rose-orange odor Option D: Petroleum-like odor " C 24823 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-][O+]=O Question about this molecule: What is the odor of this molecule? Option A: It has a sweet odor detectable by most people at a concentration of 1 part per million (1 ppm). Option B: Characteristic odor in concentrations less than 2 ppm Option C: It has a fishlike odor at low concentrations changing to ammonia-like odor at higher concentrations. Option D: It has a distinctive odor that is somewhat milder and sweeter than ethanol. " B 6276 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCO Question about this molecule: What is the odor of this molecule? Option A: Mild odor Option B: Mild pleasant odor Option C: Mild, sweet odor Option D: Mild to moderately strong odor " D 13539 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(COC(=O)C(=C)C)O Question about this molecule: What is the odor of this molecule? Option A: It has a strong unpleasant odor. Option B: It has a weak unpleasant odor. Option C: Light unpleasant odor Option D: It has an unpleasant odor. " C 6344 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: Mild pleasant odor Option B: Mild odor Option C: Mild to moderately strong odor Option D: Mild, sweet odor " D 7965 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(CC1)N Question about this molecule: What is the odor of this molecule? Option A: Odor of fingernail polish Option B: Odor of garlic or decaying fish Option C: Odor of household bleach Option D: Odor of ammonia " D 5144 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCC1=CC2=C(C=C1)OCO2 Question about this molecule: What is the odor of this molecule? Option A: Odor of household bleach Option B: Odor of sassafras Option C: Odor of ammonia Option D: Odor of garlic or decaying fish " B 177 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC=O Question about this molecule: What is the odor of this molecule? Option A: It has a pungent choking odor. Option B: It has a pungent odor. Option C: It has a pungent, irritating odor. Option D: It has a pungent, acrid odor. " A 7095 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2=CC=CC=C2 Question about this molecule: What is the odor of this molecule? Option A: It has a mild pleasant odor. Option B: It has a sweet pleasant odor. Option C: It has a pleasant odor. Option D: It has a faint pleasant odor. " C 7843 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC Question about this molecule: What is the odor of this molecule? Option A: It has a faint fishy odor. Option B: It has a faint odor. Option C: It has a faint petroleum-like odor. Option D: It has a faint petroleum like odor. " C 8561 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCC Question about this molecule: What is the odor of this molecule? Option A: It is essentially odorless. Option B: It is usually odorless. Option C: It is practically odorless. Option D: It is odorless. " C 3226 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(OC(F)F)(F)F)(F)Cl Question about this molecule: What is the odor of this molecule? Option A: It is odorless to sweet. Option B: It is odorless. Option C: It is essentially odorless. Option D: It is usually odorless. " A 4093 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=C)C(=O)O Question about this molecule: What is the odor of this molecule? Option A: It has a pungent, irritating odor. Option B: It has a pungent odor of chlorine. Option C: It has a pungent odor. Option D: It has a distinct, pungent odor. " C 7618 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CO)N(CCO)CCO Question about this molecule: What is the odor of this molecule? Option A: It has a mild sweet odor. Option B: It has a mild ammonia odor. Option C: It has a mild distinctive odor. Option D: It has a mild odor. " B 4284 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)C(=O)C1=CC=CC(=C1)C Question about this molecule: What is the odor of this molecule? Option A: It has a sweet pleasant odor. Option B: It has a pleasant odor. Option C: It has a mild pleasant odor. Option D: It has a faint pleasant odor. " D 31374 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)N(C)C Question about this molecule: What is the odor of this molecule? Option A: It has a faint odor of bitter almonds. Option B: It has a faint odor of ammonia. Option C: It has a weak odor of ammonia. Option D: It has a faint odor similar to ammonia. " D 14410 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=C(C(=C(C(=C1Br)Br)Br)Br)Br)OC2=C(C(=C(C(=C2Br)Br)Br)Br)Br Question about this molecule: What is the odor of this molecule? Option A: It has a characteristic aromatic odor. Option B: It has a chemical odor. Option C: It has a mild distinctive odor. Option D: It has a characteristic odor. " B 6385 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)N Question about this molecule: What is the odor of this molecule? Option A: It has a mild distinctive odor. Option B: It has a mild ammonia odor. Option C: It has a slight ammonia-like odor. Option D: It has an ammonia-like odor. " D 3080 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(CS)S)O Question about this molecule: What is the odor of this molecule? Option A: It has a pungent, acrid odor. Option B: It has a pungent, irritating odor. Option C: It has a pungent odor. Option D: It has a pungent offensive odor of mercaptans. " D 8846 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOC(=O)C=C Question about this molecule: What is the odor of this molecule? Option A: It has a sharp, strong odor. Option B: It has a sharp characteristic odor. Option C: It has a sharp odor. Option D: It has a sharp, sweet odor. " B 6386 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)O Question about this molecule: What is the odor of this molecule? Option A: It has a faint alcohol odor. Option B: It has a sharp alcohol odor. Option C: It has a faint odor of alcohol. Option D: It has a mild, choking alcohol odor. " B 3016 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3 Question about this molecule: What is the odor of this molecule? Option A: It is usually odorless. Option B: It is essentially odorless. Option C: It is practically odorless. Option D: It is odorless. " C 2723923 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)[O-].[NH4+] Question about this molecule: What is the odor of this molecule? Option A: It has a strong odor of vinegar. Option B: It has an odor of ammonia. Option C: It has a weak odor of ammonia. Option D: It has a faint odor of ammonia. " C 8030 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CSC=C1 Question about this molecule: What is the odor of this molecule? Option A: It has an almond odor. Option B: It has an unpleasant smell. Option C: It has an unpleasant odor. Option D: It has an odor of gasoline. " C 8419 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C=C(C=C1)C=O)OC Question about this molecule: What is the odor of this molecule? Option A: It has an almond odor. Option B: It has an odor of vanilla beans. Option C: It has an odor of gasoline. Option D: It has an odor of lemon. " B 1145 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+](C)(C)[O-] Question about this molecule: What is the odor of this molecule? Option A: It has an odor of amine. Option B: It has an odor of degrading seafood. Option C: It has an odor of ammonia. Option D: It has an odor of pears. " B 24489 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]S(=O)S(=O)[O-].[Na+].[Na+] Question about this molecule: What is the odor of this molecule? Option A: It has a sulfur dioxide-like odor. Option B: It has a petroleum-like odor. Option C: It has a lemon-like odor. Option D: It has a sulfur-like odor. " A 22311 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CCC(CC1)C(=C)C Question about this molecule: What is the odor of this molecule? Option A: It has an odor of chlorine. Option B: It has an odor of lemon. Option C: It has an aromatic odor. Option D: It has an odor of gasoline. " B 428 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CN)CN Question about this molecule: What is the odor of this molecule? Option A: It has an odor of degrading seafood. Option B: It has an odor of amine. Option C: It has an odor of pears. Option D: It has an odor of rubbing alcohol. " B 6811 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=O)OC2=O Question about this molecule: What is the odor of this molecule? Option A: It has a mild odor. Option B: It has a mild distinctive odor. Option C: It has a mild sweet odor. Option D: It has a mild pleasant odor. " B 3423265 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCOS(=O)(=O)[O-].[Na+] Question about this molecule: What is the odor of this molecule? Option A: It has a mild sweet odor. Option B: It has a mild distinctive odor. Option C: It has a mild odor. Option D: It has a mild pleasant odor. " C 11552 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CC=O Question about this molecule: What is the odor of this molecule? Option A: It has a suffocating odor. Option B: It has a weak suffocating odor. Option C: It has a suffocating pungent odor. Option D: It has a pungent choking odor. " B 5355863 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C(=C\\C(=O)OC)/OP(=O)(OC)OC Question about this molecule: What is the odor of this molecule? Option A: It has a weak odor. Option B: It has a strong odor. Option C: It has a faint odor. Option D: It has a mild odor. " A 5971 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCN=C=S Question about this molecule: What is the odor of this molecule? Option A: It has an aromatic odor. Option B: It has an odor of lemon. Option C: It has an irritating odor. Option D: It has an almond odor. " C 60962 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)NN.Cl Question about this molecule: What is the odor of this molecule? Option A: It has a strong odor. Option B: It has a weak medicine odor. Option C: It has a weak odor. Option D: It has a weak aromatic odor. " D 7964 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a pineapple-like odor. Option B: It has an almond-like odor. Option C: It has a lemon-like odor. Option D: It has an aromatic, almond-like odor. " D 10484 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)S Question about this molecule: What is the odor of this molecule? Option A: It has a strong, offensive odor. Option B: It has a strong, unpleasant odor. Option C: It has a strong, sweet odor. Option D: It has a strong odor. " B 8071 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCOC Question about this molecule: What is the odor of this molecule? Option A: It has a sharp, sweet odor. Option B: It has a sharp, strong odor. Option C: It has a sharp characteristic odor. Option D: It has a sharp odor. " D 444266 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=C\\C(=O)O)\\C(=O)O Question about this molecule: What is the odor of this molecule? Option A: It has a faint pleasant odor. Option B: It has a sweet pleasant odor. Option C: It has a faint odor. Option D: It has a pleasant odor. " C 996 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)O Question about this molecule: What is the odor of this molecule? Option A: It has a more intense vanilla odor and taste than vanillin. Option B: It has a sickeningly sweet and tarry odor. Option C: It has a mild non-residual odor. Option D: It has a very faint aromatic or phenolic odor. " B 4659569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)C(=O)C2=CC(=C(C(=C2)O)O)[N+](=O)[O-] Question about this molecule: What is the odor of this molecule? Option A: It is practically odorless. Option B: It is odorless. Option C: It is usually odorless. Option D: It is essentially odorless. " B 7410 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C1=CC=CC=C1 Question about this molecule: What is the odor of this molecule? Option A: It has a fishy odor resembling odor of ammonia. Option B: It has an odor of ammonia. Option C: It has an odor resembling the odor of oranges. Option D: It has an odor resembling that of ammonia. " C 5366415 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC(=S)[S-].[Na+] Question about this molecule: What is the odor of this molecule? Option A: It has a pungent mercaptan-like odor. Option B: It is odorless when pure; technical grade has a slightly pungent odor. Option C: It has a distinctive odor that is somewhat milder and sweeter than ethanol. Option D: It has an odor of amine and sulfur that varies in intensity. " D 16248 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC(=C1SC)C)OC(=O)NC Question about this molecule: What is the odor of this molecule? Option A: It has a mild distinctive odor. Option B: It has a mild odor. Option C: It has a mild pleasant odor. Option D: It has a mild sweet odor. " B 6497 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COS(=O)(=O)OC Question about this molecule: What is the odor of this molecule? Option A: It has a mild non-residual odor. Option B: It has a very faint aromatic or phenolic odor. Option C: It has a more intense vanilla odor and taste than vanillin. Option D: It is odorless to a faint onion-like odor. " D 6654 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CCC2CC1C2(C)C Question about this molecule: What is the odor of this molecule? Option A: It has a mild ethereal odor. Option B: It has a turpentine odor. Option C: It has a faint ethereal odor. Option D: It has an ethereal odor. " B 8881 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCl)CCl Question about this molecule: What is the odor of this molecule? Option A: It has a faint pleasant odor. Option B: It has a sweet pleasant odor. Option C: It has a sweet odor. Option D: It has a pleasant odor. " C 8082 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCNCC1 Question about this molecule: What is the odor of this molecule? Option A: It has a pepper-like odor. Option B: It has a lemon-like odor. Option C: It has a pineapple-like odor. Option D: It has a garlic-like odor. " A 13836 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+](C)(C)CCCl.[Cl-] Question about this molecule: What is the odor of this molecule? Option A: It has a fishlike odor. Option B: It has a faint, fishlike odor. Option C: It has a fishy odor. Option D: It has a faint fishy odor. " A 2788 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC2=C(C(=C(C=C2Cl)I)O)N=C1 Question about this molecule: What is the odor of this molecule? Option A: It is practically odorless. Option B: It is essentially odorless. Option C: It is odorless. Option D: It is usually odorless. " A 9223 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CO2 Question about this molecule: What is the odor of this molecule? Option A: It has a sweet odor. Option B: It has a sweet-smelling odor. Option C: It has a pleasant odor. Option D: It has a sweet pleasant odor. " B 7298 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(C1)O Question about this molecule: What is the odor of this molecule? Option A: It has a mild pleasant odor. Option B: It has a faint pleasant odor. Option C: It has a sweet pleasant odor. Option D: It has a pleasant odor. " D 6591 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)Cl)(Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a sweet pleasant odor. Option B: It has a pleasant odor. Option C: It has a sweet odor. Option D: It has a faint pleasant odor. " C 638011 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC/C(=C/C=O)/C)C Question about this molecule: What is the odor of this molecule? Option A: It has a pineapple-like odor. Option B: It has a faint petroleum-like odor. Option C: It has a pleasant lemon-like odor. Option D: It has a lemon-like odor. " D 8184 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCO Question about this molecule: What is the odor of this molecule? Option A: It has a mild distinctive odor. Option B: It has a mild odor. Option C: It has a mild pleasant odor. Option D: It has a mild sweet odor. " B 6511 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[Pb](CC)(CC)CC Question about this molecule: What is the odor of this molecule? Option A: It has a faint, characteristic odor. Option B: It has a sharp characteristic odor. Option C: It has a characteristic odor. Option D: It has a characteristic aromatic odor. " C 8133 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOCCO Question about this molecule: What is the odor of this molecule? Option A: It has a mild odor. Option B: It has a mild, sweet odor. Option C: It has a mild, pleasant odor. Option D: It has a mild pleasant odor. " C 9086 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CN)CO Question about this molecule: What is the odor of this molecule? Option A: It has a faint fishy odor. Option B: It has a fishy odor. Option C: It has a fishlike odor. Option D: It has a faint, fishlike odor. " B 15450 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CCCCCO Question about this molecule: What is the odor of this molecule? Option A: It has a pleasant odor. Option B: It has a sweet pleasant odor. Option C: It has a faint pleasant odor. Option D: It has a mild pleasant odor. " C 3314 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C=CC(=C1)CC=C)O Question about this molecule: What is the odor of this molecule? Option A: It has an odor of cloves. Option B: It has an odor of grapes. Option C: It has an odor of gasoline. Option D: It has an odor of vanilla beans. " A 1030 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CO)O Question about this molecule: What is the odor of this molecule? Option A: It is essentially odorless. Option B: It is usually odorless. Option C: It is practically odorless. Option D: It is odorless. " B 180 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C Question about this molecule: What is the odor of this molecule? Option A: It has a distinct smell and taste. Option B: It has a sweet smell. Option C: It has an unpleasant smell. Option D: It has a mild, sweet smell. " A 7288 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)CC Question about this molecule: What is the odor of this molecule? Option A: It has an agreeable ether-like odor. Option B: It has an ether-like odor. Option C: It has an acetone-like odor. Option D: It has an agreeable aromatic odor. " C 8130 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCC=O Question about this molecule: What is the odor of this molecule? Option A: It has a mild fruity odor. Option B: It has a sweet fruity odor. Option C: It has a strong fruity odor. Option D: It has a fruity odor. " C 8141 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCC Question about this molecule: What is the odor of this molecule? Option A: It has a sharp, sweet odor. Option B: It has a sharp, strong odor. Option C: It has a sharp odor. Option D: It has a sharp characteristic odor. " C 1140 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1 Question about this molecule: What is the odor of this molecule? Option A: It has a characteristic aromatic odor. Option B: It has a faint, characteristic odor. Option C: It has a sharp characteristic odor. Option D: It has a characteristic odor. " A 612 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C(=O)O)O Question about this molecule: What is the odor of this molecule? Option A: It is practically odorless. Option B: It is usually odorless. Option C: It is essentially odorless. Option D: It is odorless. " D 6561 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C=O Question about this molecule: What is the odor of this molecule? Option A: It has a pungent, irritating odor. Option B: It has a pungent odor of chlorine. Option C: It has a distinct, pungent odor. Option D: It has a pungent odor. " D 7871 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)OP(=O)(C)F Question about this molecule: What is the odor of this molecule? Option A: It has no odor. Option B: It has almost no odor. Option C: It has little or no odor. Option D: It has almost no odor in its pure state. " D 935 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Ni] Question about this molecule: What is the odor of this molecule? Option A: It has little or no odor. Option B: It has no characteristic odor or taste. Option C: It has almost no odor in its pure state. Option D: It has almost no odor. " B 9740 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C#N)C(=O)O Question about this molecule: What is the odor of this molecule? Option A: It has an odor of gasoline. Option B: It has an almond odor. Option C: It has an unpleasant smell. Option D: It has an unpleasant odor. " D 31285 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCC=C Question about this molecule: What is the odor of this molecule? Option A: It has an aromatic odor. Option B: It has an odor of lemon. Option C: It has an odor of chlorine. Option D: It has an odor of gasoline. " D 6914 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1Cl)O)Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a strong, sweet odor. Option B: It has a faint, sweet odor. Option C: It has a sharp, strong odor. Option D: It has a sharp, sweet odor. " A 713 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)N Question about this molecule: What is the odor of this molecule? Option A: It has a faint odor of ammonia. Option B: It has a weak odor of ammonia. Option C: It has an odor of ammonia. Option D: It has a strong odor of vinegar. " A 6567 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CN)N Question about this molecule: What is the odor of this molecule? Option A: It has an ammonia-like odor. Option B: It has a mild distinctive odor. Option C: It has a slight ammonia-like odor. Option D: It has a mild ammonia odor. " A 8376 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: What is the odor of this molecule? Option A: It is essentially odorless. Option B: It is practically odorless. Option C: It is usually odorless. Option D: It is odorless. " D 2724385 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5C[C@H]([C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)O)C)C)C)O)O Question about this molecule: What is the odor of this molecule? Option A: It is odorless. Option B: It is usually odorless. Option C: It is practically odorless. Option D: It is essentially odorless. " A 246728 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC(=O)CC Question about this molecule: What is the odor of this molecule? Option A: It has a pungent, irritating odor. Option B: It has a pungent odor of chlorine. Option C: It has a pungent odor. Option D: It has a distinct, pungent odor. " C 3283 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOCC Question about this molecule: What is the odor of this molecule? Option A: It has an anesthetic odor. Option B: It has an irritating odor. Option C: It has an aromatic odor. Option D: It has an offensive odor. " A 8892 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC(=O)O Question about this molecule: What is the odor of this molecule? Option A: It has an odor of gasoline. Option B: It has an unpleasant smell. Option C: It has an almond odor. Option D: It has an unpleasant odor. " D 6564 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CCl)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a pineapple-like odor. Option B: It has a tar-like odor. Option C: It has a chloroform-like odor. Option D: It has a phenol-like odor. " C 6214 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)(Cl)Cl)(Cl)(Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a tar-like odor. Option B: It has a pineapple-like odor. Option C: It has a pepper-like odor. Option D: It has a camphor-like odor. " D 4169 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC1=CC=CC(=C1N(C(C)COC)C(=O)CCl)C Question about this molecule: What is the odor of this molecule? Option A: Slight odor Option B: It is practically odorless. Option C: Slightly sweet odor Option D: It is usually odorless. " C 6337 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCl Question about this molecule: What is the odor of this molecule? Option A: Irritating odor Option B: Pungent burning sulfur odor Option C: Pungent odor Option D: Weak sour odor " C 1100 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OS(=O)O Question about this molecule: What is the odor of this molecule? Option A: Weak sour odor Option B: Irritating odor Option C: Pungent odor Option D: Pungent burning sulfur odor " D 6001 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C2C=CC3=CC=CC=C3C2=C(C4=CC=CC=C14)C Question about this molecule: What is the odor of this molecule? Option A: It is usually odorless. Option B: It is practically odorless. Option C: It is odorless. Option D: It is essentially odorless. " C 8003 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC Question about this molecule: What is the odor of this molecule? Option A: Sweet fat-like odor Option B: Mustard-like odor Option C: Fishlike odor Option D: Petroleum-like odor " D 8530 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=O)C=CC(=O)C2=C1 Question about this molecule: What is the odor of this molecule? Option A: It has a faint petroleum-like odor. Option B: It has a faint petroleum like odor. Option C: Sharp odor similar to benzoquinone Option D: It smells like rotten eggs. " C 18502 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(CC1)N=C=O Question about this molecule: What is the odor of this molecule? Option A: Irritating odor Option B: Slightly sweet odor Option C: Fishlike odor Option D: Weak sour odor " A 3286 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)SCSP(=S)(OCC)OCC Question about this molecule: What is the odor of this molecule? Option A: It has a disagreeable odor. Option B: Disagreeable odor Option C: Agreeable odor Option D: It has a distinctive, disagreeable odor. " B 23670523 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1N)[As](=O)(O)[O-].[Na+] Question about this molecule: What is the odor of this molecule? Option A: It is essentially odorless. Option B: It is practically odorless. Option C: It is usually odorless. Option D: It is odorless. " D 6422 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(F)(F)F)O Question about this molecule: What is the odor of this molecule? Option A: Irritating odor Option B: Weak sour odor Option C: Pungent burning sulfur odor Option D: Pungent odor " D 6432 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(F)(F)F)(C(F)(F)F)(F)F Question about this molecule: What is the odor of this molecule? Option A: It is odorless. Option B: It is practically odorless. Option C: It is essentially odorless. Option D: It is usually odorless. " A 6570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C=C Question about this molecule: What is the odor of this molecule? Option A: Irritating odor Option B: Pungent odor Option C: Weak sour odor Option D: Pungent burning sulfur odor " B 6423 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([N+](=O)[O-])(Cl)(Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: No odor. Option B: Strong odor. Option C: Strong odor of ammonia Option D: Strong irritating odor " D 8035 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)CCC(=O)C Question about this molecule: What is the odor of this molecule? Option A: Mustard-like odor Option B: Sweet fat-like odor Option C: Fishlike odor Option D: Sweet aromatic odor " D 8174 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCO Question about this molecule: What is the odor of this molecule? Option A: Mustard-like odor Option B: Sweet fat-like odor Option C: Fishlike odor Option D: Sweet aromatic odor " B 3347 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C(C1=CC=C(C=C1)Cl)C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3 Question about this molecule: What is the odor of this molecule? Option A: It has a mild sweet odor. Option B: It has a mild odor. Option C: It has a mild distinctive odor. Option D: It has a mild pleasant odor. " B 264 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(=O)O Question about this molecule: What is the odor of this molecule? Option A: It has a penetrating odor. Option B: It has a penetrating aromatic odor. Option C: It has a penetrating and unpleasant odor. Option D: It has a penetrating unpleasant odor. " C 152119 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OP(=S)(O)S Question about this molecule: What is the odor of this molecule? Option A: It has a sulfur-like odor. Option B: It has a sulfur dioxide-like odor. Option C: It has a lemon-like odor. Option D: It has a petroleum-like odor. " A 2871 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OC1=CC2=C(C=C1)C(=C(C(=O)O2)Cl)C Question about this molecule: What is the odor of this molecule? Option A: It has a slight aromatic odor. Option B: It has a slight sulfur odor. Option C: It has a slight odor. Option D: It has a slight sulfurous odor. " D 28780 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCNC(=O)N1C2=CC=CC=C2N=C1NC(=O)OC Question about this molecule: What is the odor of this molecule? Option A: It has a mild ethereal odor. Option B: It has a faint acrid odor. Option C: It has an ethereal odor. Option D: It has a faint ethereal odor. " B 6287 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[C@@H](C(=O)O)N Question about this molecule: What is the odor of this molecule? Option A: It has a characteristic urinary odor. Option B: It has a characteristic vinous odor. Option C: It has a characteristic aromatic odor. Option D: It has a characteristic odor. " A 7855 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC#N Question about this molecule: What is the odor of this molecule? Option A: It has a sharp, onion- or garlic-like odor. Option B: It has a garlic-like odor. Option C: It has a pineapple-like odor. Option D: It has a garlic-like or fishy odor. " A 679 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CS(=O)C Question about this molecule: What is the odor of this molecule? Option A: It is odorless. Option B: It is usually odorless. Option C: It is essentially odorless. Option D: It is practically odorless. " C 5371560 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C(=C\\C(=O)N(C)C)/OP(=O)(OC)OC Question about this molecule: What is the odor of this molecule? Option A: It has a slight ester odor. Option B: It has a mild distinctive odor. Option C: It has a mild ester odor. Option D: It has a mild odor. " C 8150 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCOCCOC Question about this molecule: What is the odor of this molecule? Option A: It has a faint pleasant odor. Option B: It has a pleasant odor. Option C: It has a mild pleasant odor. Option D: It has a sweet pleasant odor. " B 8400 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(C(=O)C2=CC=CC=C2)O Question about this molecule: What is the odor of this molecule? Option A: It has an almond odor. Option B: It has an odor of camphor. Option C: It has an odor of gasoline. Option D: It has an odor of lemon. " B 6342 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC#N Question about this molecule: What is the odor of this molecule? Option A: It has an aromatic odor. Option B: It has an odor of lemon. Option C: It has an almond odor. Option D: It has an odor of gasoline. " A 13192 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCCN=C=O)CCN=C=O Question about this molecule: What is the odor of this molecule? Option A: It has a weak odor. Option B: It has a mild odor. Option C: It has a strong odor. Option D: It has a faint odor. " C 12217 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCOC(=O)CC Question about this molecule: What is the odor of this molecule? Option A: It has an almond-like odor. Option B: It has an irritating odor. Option C: It has an apple-like odor. Option D: It has an almond odor. " C 10178 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C1=C(C=C(C=C1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: What is the odor of this molecule? Option A: It is practically odorless. Option B: It is usually odorless. Option C: It is odorless. Option D: It is essentially odorless. " C 8078 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCCCC1 Question about this molecule: What is the odor of this molecule? Option A: It has a garlic-like odor. Option B: It has a petroleum-like odor. Option C: It has a pineapple-like odor. Option D: It has a lemon-like odor. " B 15910 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(#N)C1=C(C(=C(C(=C1Cl)Cl)Cl)C#N)Cl Question about this molecule: What is the odor of this molecule? Option A: It is odorless when pure; technical grade has a slightly pungent odor. Option B: It has a pungent mercaptan-like odor. Option C: It has an odor of amine and sulfur that varies in intensity. Option D: It has a distinctive odor that is somewhat milder and sweeter than ethanol. " A 6944 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1[N+](=O)[O-] Question about this molecule: What is the odor of this molecule? Option A: It has a characteristic odor. Option B: It has a characteristic aromatic odor. Option C: It has a characteristic urinary odor. Option D: It has a characteristic odor of aromatic nitro compounds. " D 3032604 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)C(=O)/C(=C(\\C)/OP(=O)(OC)OC)/Cl Question about this molecule: What is the odor of this molecule? Option A: It has a pleasant odor. Option B: It has a faint pleasant odor. Option C: It has a sweet pleasant odor. Option D: It has a faint odor. " D 6593 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)Cl)(Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a pungent odor of chlorine. Option B: It has a pungent, irritating odor. Option C: It has a pungent odor. Option D: It has a distinct, pungent odor. " C 5206 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(OC(C(F)(F)F)C(F)(F)F)F Question about this molecule: What is the odor of this molecule? Option A: It has a sweet pleasant odor. Option B: It has a faint pleasant odor. Option C: It has a pleasant odor. Option D: It has a mild pleasant odor. " C 23690444 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)[O-])S.[Na+] Question about this molecule: What is the odor of this molecule? Option A: It has a slight unpleasant odor. Option B: It has a slight aromatic odor. Option C: It has a slight sulfurous odor. Option D: It has a slight odor. " D 6327 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCl Question about this molecule: What is the odor of this molecule? Option A: It has a sharp, sweet odor. Option B: It has a strong, sweet odor. Option C: It has a faint, characteristic odor. Option D: It has a faint, sweet odor. " D 6351 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC1 Question about this molecule: What is the odor of this molecule? Option A: It has a petroleum-like odor. Option B: It has a garlic-like odor. Option C: It has a lemon-like odor. Option D: It has a pineapple-like odor. " A 21013 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=C(C(=C1Cl)Cl)Cl)Cl)O Question about this molecule: What is the odor of this molecule? Option A: It has a strong odor. Option B: It has a strong odor similar to apples. Option C: It has a strong odor of vinegar. Option D: It has a strong medicinal odor. " D 3024 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Br)Br Question about this molecule: What is the odor of this molecule? Option A: It has a sweet pleasant odor. Option B: It has a mild pleasant odor. Option C: It has a pleasant odor. Option D: It has a faint pleasant odor. " C 637566 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC/C(=C/CO)/C)C Question about this molecule: What is the odor of this molecule? Option A: It has a sweet rose odor. Option B: It has a sweet pleasant odor. Option C: It has a pleasant odor. Option D: It has a sweet odor. " A 643460 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C=C/C=C/C(=O)O Question about this molecule: What is the odor of this molecule? Option A: It has a pleasant odor. Option B: It has a faint odor. Option C: It has a sweet pleasant odor. Option D: It has a faint pleasant odor. " B 7416 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: What is the odor of this molecule? Option A: It has an apple-like odor. Option B: It has an almond odor. Option C: It has an almond-like odor. Option D: It has an irritating odor. " C 8785 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)OCC1=CC=CC=C1 Question about this molecule: What is the odor of this molecule? Option A: It has an odor of amine. Option B: It has an odor of pears. Option C: It has an odor of rubbing alcohol. Option D: It has an odor of degrading seafood. " B 9584 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)N)F Question about this molecule: What is the odor of this molecule? Option A: It has a mild odor. Option B: It has a mild pleasant odor. Option C: It has a mild sweet odor. Option D: It has a mild distinctive odor. " C 7848 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCS Question about this molecule: What is the odor of this molecule? Option A: It has a strong, unpleasant odor. Option B: It has a strong odor. Option C: It has a strong, offensive odor. Option D: It has a strong, sweet odor. " C 460 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC=CC=C1O Question about this molecule: What is the odor of this molecule? Option A: It has a smoky odor. Option B: It has a fishy odor. Option C: It has a faint fishy odor. Option D: It has a fishlike odor. " A 31370 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CCl)O Question about this molecule: What is the odor of this molecule? Option A: It has a weak suffocating odor. Option B: It has a mild non-residual odor. Option C: It has a very faint aromatic or phenolic odor. Option D: It has a more intense vanilla odor and taste than vanillin. " B 12228 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN=C=O Question about this molecule: What is the odor of this molecule? Option A: It has a sharp, sweet odor. Option B: It has a sharp, strong odor. Option C: It has a sharp, irritating odor. Option D: It has a strong, sweet odor. " B 31256 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)CC(C)(C)O Question about this molecule: What is the odor of this molecule? Option A: It has a mild pleasant odor. Option B: It has a sweet pleasant odor. Option C: It has a pleasant odor. Option D: It has a faint pleasant odor. " C 5280970 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(/C=C\\Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a sweet odor. Option B: It has a sweet pleasant odor. Option C: It has a sweetish odor. Option D: It has a pleasant odor. " C 342 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC=C1)O Question about this molecule: What is the odor of this molecule? Option A: It has a sweet odor. Option B: It has a sweet tarry odor. Option C: It has a sweet pleasant odor. Option D: It has a mild sweet odor. " B 1004 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OP(=O)(O)O Question about this molecule: What is the odor of this molecule? Option A: It is essentially odorless. Option B: It is usually odorless. Option C: It is practically odorless. Option D: It is odorless. " D 5943 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)(Cl)(Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a characteristic aromatic odor. Option B: It has a characteristic odor. Option C: It has a faint, characteristic odor. Option D: It has a sharp characteristic odor. " B 178 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)N Question about this molecule: What is the odor of this molecule? Option A: It has a faint fishy odor. Option B: It has a fishy odor. Option C: It has a mousy odor. Option D: It has a fishlike odor. " C 3082 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC(=O)CSP(=S)(OC)OC Question about this molecule: What is the odor of this molecule? Option A: It has a camphor-like odor. Option B: It has a pineapple-like odor. Option C: It has a tar-like odor. Option D: It has a pepper-like odor. " A 7505 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C#N Question about this molecule: What is the odor of this molecule? Option A: It has an almond-like odor. Option B: It has an almond odor. Option C: It has an apple-like odor. Option D: It has an irritating odor. " A 8189 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCOCCOCCOC Question about this molecule: What is the odor of this molecule? Option A: It has a faint ethereal odor. Option B: It has a mild distinctive odor. Option C: It has an ethereal odor. Option D: It has a mild ethereal odor. " D 6115 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)N Question about this molecule: What is the odor of this molecule? Option A: It has a characteristic odor. Option B: It has a characteristic aromatic odor. Option C: It has a faint, characteristic odor. Option D: It has a sharp characteristic odor. " A 8134 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCOCCO Question about this molecule: What is the odor of this molecule? Option A: It has a sweet odor. Option B: It has a pleasant odor. Option C: It has a sweet pleasant odor. Option D: It has a faint pleasant odor. " A 3893 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCC(=O)O Question about this molecule: What is the odor of this molecule? Option A: It has a slight odor. Option B: It has a slight odor of garlic. Option C: It has a slight odor of bay oil. Option D: It has a slight garlic odor. " C 454 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCC=O Question about this molecule: What is the odor of this molecule? Option A: It has a mild fruity odor. Option B: It has a sweet fruity odor. Option C: It has a strong fruity odor. Option D: It has a fruity odor. " C 4116 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(C(Cl)Cl)(F)F Question about this molecule: What is the odor of this molecule? Option A: It has a sweet fruity odor. Option B: It has a strong fruity odor. Option C: It has a fruity odor. Option D: It has a mild fruity odor. " A 7835 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C(O1)CCl Question about this molecule: What is the odor of this molecule? Option A: It has a sweet chloroform-like odor. Option B: It has a chloroform-like odor. Option C: It has an irritating chloroform-like odor. Option D: It has a geranium-like odor. " C 7991 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(=O)O Question about this molecule: What is the odor of this molecule? Option A: It has a penetrating odor. Option B: It has a penetrating aromatic odor. Option C: It has a penetrating and unpleasant odor. Option D: It has a penetrating unpleasant odor. " D 7768 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(=O)NCC1 Question about this molecule: What is the odor of this molecule? Option A: It has a mild, disagreeable odor. Option B: It has a mild, sweet odor. Option C: It has a mild, pleasant odor. Option D: It has a mild pleasant odor. " A 10461 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCl)SCCCl Question about this molecule: What is the odor of this molecule? Option A: It has a faint odor of alcohol. Option B: It has a faint odor of bitter almonds. Option C: It has a faint odor of ammonia. Option D: It has a faint odor of mustard/garlic. " D 7418 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC=C1)C(=O)O Question about this molecule: What is the odor of this molecule? Option A: It has a pepper-like odor. Option B: It has a floral-honey odor. Option C: It has a pineapple-like odor. Option D: It has a peppermint odor. " B 880 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C=O Question about this molecule: What is the odor of this molecule? Option A: It has a pungent odor. Option B: It has a distinct, pungent odor. Option C: It has a pungent, irritating odor. Option D: It has a pungent odor of chlorine. " A 6329 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN Question about this molecule: What is the odor of this molecule? Option A: It has an odor resembling that of ammonia. Option B: It has a fishy odor resembling odor of ammonia. Option C: It has an odor resembling the odor of oranges. Option D: It has an odor of ammonia. " B 6623 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C1=CC=C(C=C1)O)C2=CC=C(C=C2)O Question about this molecule: What is the odor of this molecule? Option A: It has a weak aromatic odor. Option B: It has a weak odor. Option C: It has a strong odor. Option D: It has a weak medicine odor. " D 7966 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(CC1)O Question about this molecule: What is the odor of this molecule? Option A: It has a camphor-like odor. Option B: It has a pepper-like odor. Option C: It has a pineapple-like odor. Option D: It has a tar-like odor. " A 125468 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C=C(\\C)/C(=O)O Question about this molecule: What is the odor of this molecule? Option A: It has a fruity, aromatic odor. Option B: It has a fruity odor. Option C: It has a fruity, pleasant odor. Option D: It has a fruity or spicy odor. " D 398 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[N+](=O)[O-] Question about this molecule: What is the odor of this molecule? Option A: It has a sweet fruity odor. Option B: It has a fruity odor. Option C: It has a strong fruity odor. Option D: It has a mild fruity odor. " D 7360 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC(OC1)CO Question about this molecule: What is the odor of this molecule? Option A: It has a mild sweet odor. Option B: It has a mild pleasant odor. Option C: It has a mild odor. Option D: It has a mild distinctive odor. " C 281 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C-]#[O+] Question about this molecule: What is the odor of this molecule? Option A: It is practically odorless. Option B: It is essentially odorless. Option C: It is odorless. Option D: It is usually odorless. " C 240 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C=O Question about this molecule: What is the odor of this molecule? Option A: It has a bitter almond odor. Option B: It has a sweet-smelling odor. Option C: It has a mild distinctive odor. Option D: It has a sweet odor. " A 11638 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CF Question about this molecule: What is the odor of this molecule? Option A: It has an ether-like odor. Option B: It has an agreeable ether-like odor. Option C: It has an agreeable aromatic odor. Option D: It has an agreeable odor. " B 162637 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C@@H]([C@H](C(=O)[O-])O)(C(=O)[O-])O.[Na+].[Na+] Question about this molecule: What is the odor of this molecule? Option A: It is usually odorless. Option B: It is essentially odorless. Option C: It is odorless. Option D: It is practically odorless. " C 6259 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(=O)CBr Question about this molecule: What is the odor of this molecule? Option A: It has a sharp characteristic odor. Option B: It has a sharp, sweet odor. Option C: It has a sharp odor. Option D: It has a sharp, strong odor. " C 8800 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C(=O)NC1=CC=C(C=C1)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a slight aromatic odor. Option B: It has a slight sulfurous odor. Option C: It has a slight odor. Option D: It has a slight unpleasant odor. " C 7859 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C#CCO Question about this molecule: What is the odor of this molecule? Option A: It has an irritating chloroform-like odor. Option B: It has a geranium-like odor. Option C: It has a strong mothball-like odor. Option D: It has a sweet chloroform-like odor. " B 931 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C=CC=CC2=C1 Question about this molecule: What is the odor of this molecule? Option A: It has a pungent, irritating odor. Option B: It has a pungent odor of chlorine. Option C: It has a distinct, pungent odor. Option D: It has a pungent odor. " C 222 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: N Question about this molecule: What is the odor of this molecule? Option A: It has a very distinct odor. Option B: It has a mild odor. Option C: It has a mild sweet odor. Option D: It has a mild distinctive odor. " A 4420 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=O)(OC)OC(C(Cl)(Cl)Br)Br Question about this molecule: What is the odor of this molecule? Option A: It has a pungent, irritating odor. Option B: It has a pungent odor of chlorine. Option C: It has a distinct, pungent odor. Option D: It has a pungent odor. " D 650 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C(=O)C Question about this molecule: What is the odor of this molecule? Option A: It has a pleasant lemon-like odor. Option B: It has a mild gasoline-like odor. Option C: It has a strong chlorine-like odor. Option D: It has a faint petroleum-like odor. " C 9033 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN1 Question about this molecule: What is the odor of this molecule? Option A: It has a mild ammonia odor. Option B: It has an ammonia-like odor. Option C: It has a mild distinctive odor. Option D: It has a slight ammonia-like odor. " B 7839 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CBr)Br Question about this molecule: What is the odor of this molecule? Option A: It has a mild odor. Option B: It has a mild, sweet odor. Option C: It has a mild, pleasant odor. Option D: It has a mild pleasant odor. " B 1322 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNNC Question about this molecule: What is the odor of this molecule? Option A: It has a mild ammonia odor. Option B: It has an ammonia-like odor. Option C: It has a slight ammonia-like odor. Option D: It has a mild distinctive odor. " B 8900 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCC Question about this molecule: What is the odor of this molecule? Option A: It has a lemon-like odor. Option B: It has a pineapple-like odor. Option C: It has a garlic-like odor. Option D: It has a petroleum-like odor. " D 6323 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CBr Question about this molecule: What is the odor of this molecule? Option A: It has almost no odor. Option B: It has no odor. Option C: It has no distinct smell. Option D: It has little or no odor. " C 1032 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)O Question about this molecule: What is the odor of this molecule? Option A: It has a sharp, sweet odor. Option B: It has a sharp rancid odor. Option C: It has a sharp, strong odor. Option D: It has a rancid odor. " B 999 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)CC(=O)O Question about this molecule: What is the odor of this molecule? Option A: It has an agreeable odor. Option B: It has a disagreeable odor. Option C: It has a slightly disagreeable odor. Option D: It has a distinctive, disagreeable odor. " B 31264 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1OC(OC(O1)C)C Question about this molecule: What is the odor of this molecule? Option A: It has a mild pleasant odor. Option B: It has a faint pleasant odor. Option C: It has a pleasant odor. Option D: It has a sweet pleasant odor. " C 284 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)O Question about this molecule: What is the odor of this molecule? Option A: It has a pungent odor of chlorine. Option B: It has a pungent odor. Option C: It has a distinct, pungent odor. Option D: It has a pungent, irritating odor. " B 8037 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCN(C)C Question about this molecule: What is the odor of this molecule? Option A: It has a faint fishy odor. Option B: It has a faint, fishlike odor. Option C: It has a fishlike odor. Option D: It has a fishy odor. " C 8452 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(=O)C1 Question about this molecule: What is the odor of this molecule? Option A: It has a petroleum-like odor. Option B: It has a lemon-like odor. Option C: It has a garlic-like odor. Option D: It has a pineapple-like odor. " A 17581 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC(=C(C=C1Cl)OC)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a musty odor. Option B: It has a fishlike odor. Option C: It has a faint fishy odor. Option D: It has a fishy odor. " A 37125 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCSP(=S)(OCC)OC1=CC=C(C=C1)SC Question about this molecule: What is the odor of this molecule? Option A: It has a tar-like odor. Option B: It has a sulfide-like odor. Option C: It has a phenol-like odor. Option D: It has a phenolic odor. " B 8020 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCOC Question about this molecule: What is the odor of this molecule? Option A: It has a phenol-like odor. Option B: It has a tar-like odor. Option C: It has a pineapple-like odor. Option D: It has a chloroform-like odor. " D 8496 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC(=C1)C(=O)O)C(=O)O Question about this molecule: What is the odor of this molecule? Option A: It has a slight unpleasant odor. Option B: It has a weak unpleasant odor. Option C: It has a strong unpleasant odor. Option D: It has a strong, unpleasant odor. " A 7452 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC(=C1)[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: What is the odor of this molecule? Option A: It has a slight odor. Option B: It has a slight aromatic odor. Option C: It has a slight sulfurous odor. Option D: It has a slight unpleasant odor. " A 8343 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC Question about this molecule: What is the odor of this molecule? Option A: It has no distinct smell. Option B: It has almost no odor. Option C: It has little or no odor. Option D: It has no odor. " B 16653 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCSC(=O)N1CCCCCC1 Question about this molecule: What is the odor of this molecule? Option A: It has an almond odor. Option B: It has an odor of gasoline. Option C: It has an odor of lemon. Option D: It has an aromatic odor. " D 13676 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(CC)SC1=CC=CC=C1 Question about this molecule: What is the odor of this molecule? Option A: It is odorless when pure; technical grade has a slightly pungent odor. Option B: It has an odor of amine and sulfur that varies in intensity. Option C: It has a pungent mercaptan-like odor. Option D: It has a distinctive odor that is somewhat milder and sweeter than ethanol. " C 1146 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C Question about this molecule: What is the odor of this molecule? Option A: It has a pungent mercaptan-like odor. Option B: It has a fishlike odor at low concentrations changing to ammonia-like odor at higher concentrations. Option C: It has a distinctive odor that is somewhat milder and sweeter than ethanol. Option D: It is odorless when pure; technical grade has a slightly pungent odor. " B 3485 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC=O)CC=O Question about this molecule: What is the odor of this molecule? Option A: It has a distinct, pungent odor. Option B: It has a pungent odor. Option C: It has a sharp, pungent odor. Option D: It has a pungent, irritating odor. " C 3026 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC Question about this molecule: What is the odor of this molecule? Option A: It is odorless. Option B: It is usually odorless. Option C: It is practically odorless. Option D: It is essentially odorless. " A 783 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [HH] Question about this molecule: What is the odor of this molecule? Option A: It is odorless. Option B: It is practically odorless. Option C: It is usually odorless. Option D: It is essentially odorless. " A 24386 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=S(Cl)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a suffocating odor. Option B: It has a suffocating pungent odor. Option C: It has a weak suffocating odor. Option D: It has a pungent choking odor. " B 7573 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NC1=CC=C(C=C1)NC2=CC=CC=C2 Question about this molecule: What is the odor of this molecule? Option A: It has an almond odor. Option B: It has an odor of gasoline. Option C: It has an odor of lemon. Option D: It has an aromatic odor. " D 2537 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C2CCC1(C(=O)C2)C)C Question about this molecule: What is the odor of this molecule? Option A: It has a strong chlorine-like odor. Option B: It has a faint petroleum-like odor. Option C: It has a strong mothball-like odor. Option D: It has a strong repulsive odor. " C 3301 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CN)N Question about this molecule: What is the odor of this molecule? Option A: It has an ammonia-like odor. Option B: It has a mild ammonia odor. Option C: It has a mild distinctive odor. Option D: It has a slight ammonia-like odor. " A 12232 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CSSC Question about this molecule: What is the odor of this molecule? Option A: It has a garlic-like odor. Option B: It has a pepper-like odor. Option C: It has a pineapple-like odor. Option D: It has a lemon-like odor. " A 7255 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)N)Cl Question about this molecule: What is the odor of this molecule? Option A: It has a mild odor. Option B: It has a mild sweet odor. Option C: It has a mild distinctive odor. Option D: It has a mild pleasant odor. " A 8813 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N.C(CS(=O)(=O)O)O.C(CS(=O)(=O)O)O Question about this molecule: What is the odor of this molecule? Option A: It has a mild, sweet odor. Option B: It has a mild, disagreeable odor. Option C: It has a slight, but pungent odor. Option D: It has a slight butyric odor. " D 8914 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCO Question about this molecule: What is the odor of this molecule? Option A: It has a fruity or spicy odor. Option B: It has a fruity, aromatic odor. Option C: It has a rose or fruity odor. Option D: It has a fruity, pleasant odor. " C 469 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(C(=O)O)N)CC(=O)O Question about this molecule: What is the right information about this molecule's oxidation? Option A: It is slowly oxidized by long exposure to air and the impurities often give it a yellowish to brownish red tint. Option B: Its oxidation is retarded in thiamine deficiency and it accumulates in the tissues, especially in nervous structures. Option C: It can be oxidized by horseradish peroxidase (HRP) to cytotoxic species. Option D: It can catalyze the oxidation of lysyl residues to 2-aminoadipic acid in human skin collagen and potentially other tissues. " D 6184 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC=O Question about this molecule: What is the right information about this molecule's oxidation? Option A: It can catalyze the oxidation of lysyl residues to 2-aminoadipic acid in human skin collagen and potentially other tissues. Option B: It can be a major breakdown product of linoleic acid (LA, n - 6 PUFA) oxidation. Option C: It can be oxidized by horseradish peroxidase (HRP) to cytotoxic species. Option D: Its oxidation is retarded in thiamine deficiency and it accumulates in the tissues, especially in nervous structures. " B 10964 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C=O)C=O Question about this molecule: What is the right information about this molecule's oxidation? Option A: It can be irreversibly oxidized to produce retinoic acid. Option B: It can produce MDA as a decomposition product. Option C: It can form cystine when oxidized, which is two of its residues joined by a disulfide bond. Option D: It can undergo oxidation of the allylic group to yield the 2, 3-epoxide. " B 1060 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C(=O)O Question about this molecule: What is the right information about this molecule's oxidation? Option A: It is slowly oxidized by long exposure to air and the impurities often give it a yellowish to brownish red tint. Option B: It can catalyze the oxidation of lysyl residues to 2-aminoadipic acid in human skin collagen and potentially other tissues. Option C: Its oxidation is retarded in thiamine deficiency and it accumulates in the tissues, especially in nervous structures. Option D: It can be oxidized by horseradish peroxidase (HRP) to cytotoxic species. " C 445354 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/CO)/C)/C Question about this molecule: What is the right information about this molecule's oxidation? Option A: Its oxidation is retarded in thiamine deficiency and it accumulates in the tissues, especially in nervous structures. Option B: It can be irreversibly oxidized to produce retinoic acid. Option C: It can catalyze the oxidation of lysyl residues to 2-aminoadipic acid in human skin collagen and potentially other tissues. Option D: It can be oxidized by horseradish peroxidase (HRP) to cytotoxic species. " B 5862 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@@H](C(=O)O)N)S Question about this molecule: What is the right information about this molecule's oxidation? Option A: It can be oxidized by horseradish peroxidase (HRP) to cytotoxic species. Option B: It can form cystine when oxidized, which is two of its residues joined by a disulfide bond. Option C: It slowly oxidizes and resinifies in air, giving a red-brown tint to aged samples. Option D: It is slowly oxidized by long exposure to air and the impurities often give it a yellowish to brownish red tint. " B 5144 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCC1=CC2=C(C=C1)OCO2 Question about this molecule: What is the right information about this molecule's oxidation? Option A: It slowly oxidizes and resinifies in air, giving a red-brown tint to aged samples. Option B: It can undergo oxidation of the allylic group to yield the 2, 3-epoxide. Option C: It can form cystine when oxidized, which is two of its residues joined by a disulfide bond. Option D: It is slowly oxidized by long exposure to air and the impurities often give it a yellowish to brownish red tint. " B 802 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=CN2)CC(=O)O Question about this molecule: What is the right information about this molecule's oxidation? Option A: It can be oxidized by horseradish peroxidase (HRP) to cytotoxic species. Option B: It can catalyze the oxidation of lysyl residues to 2-aminoadipic acid in human skin collagen and potentially other tissues. Option C: Its oxidation is retarded in thiamine deficiency and it accumulates in the tissues, especially in nervous structures. Option D: It is slowly oxidized by long exposure to air and the impurities often give it a yellowish to brownish red tint. " A 460 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC=CC=C1O Question about this molecule: What is the right information about this molecule's oxidation? Option A: It can be oxidized by horseradish peroxidase (HRP) to cytotoxic species. Option B: Its oxidation is retarded in thiamine deficiency and it accumulates in the tissues, especially in nervous structures. Option C: It can catalyze the oxidation of lysyl residues to 2-aminoadipic acid in human skin collagen and potentially other tissues. Option D: It is readily oxidized by the heme iron of peroxidases including the peroxidase of cyclooxygenase (COX) enzymes. " D 342 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC=C1)O Question about this molecule: What is the right information about this molecule's oxidation? Option A: It can be oxidized by horseradish peroxidase (HRP) to cytotoxic species. Option B: It is slowly oxidized by long exposure to air and the impurities often give it a yellowish to brownish red tint. Option C: It can catalyze the oxidation of lysyl residues to 2-aminoadipic acid in human skin collagen and potentially other tissues. Option D: It slowly oxidizes and resinifies in air, giving a red-brown tint to aged samples. " B 6115 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)N Question about this molecule: What is the right information about this molecule's oxidation? Option A: It is slowly oxidized by long exposure to air and the impurities often give it a yellowish to brownish red tint. Option B: It can be oxidized by horseradish peroxidase (HRP) to cytotoxic species. Option C: It slowly oxidizes and resinifies in air, giving a red-brown tint to aged samples. Option D: It can catalyze the oxidation of lysyl residues to 2-aminoadipic acid in human skin collagen and potentially other tissues. " C 43507 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)CC3=CC=CC=C3CN)C(=O)O)CSC4=NN=NN4CC(=O)O Question about this molecule: How is the pharmacological activity of this molecule Option A: It has limited activity against gram negative organisms. Option B: It has greater activity against Gram negative bacteria. Option C: It is less active against most gram-positive organisms. Option D: It displays broad-spectrum activity against fungi and also very low toxicity to mammals. " C 10680 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2=CC(=O)C3=CC=CC=C3O2 Question about this molecule: How is the pharmacological activity of this molecule Option A: It is the most active of the flavonoids. Option B: It has limited activity against gram negative organisms. Option C: It has greater activity against Gram negative bacteria. Option D: It is less active against most gram-positive organisms. " A 104838 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]([C@@H]1[C@H]2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O Question about this molecule: How is the pharmacological activity of this molecule Option A: It is less active against most gram-positive organisms. Option B: It displays broad-spectrum activity against fungi and also very low toxicity to mammals. Option C: It has limited activity against gram negative organisms. Option D: It has greater activity against Gram negative bacteria. " D 98888 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN1CCNCCN Question about this molecule: How is the pharmacological activity of this molecule Option A: It has major activity against mycobacteria, commonly used in combination with other agents as therapy of tuberculosis. Option B: It carries some activity against protozoans, and has been used off-label in the treatment of toxoplasmosis, malaria, and babesiosis. Option C: It is investigated for its use in treating cardiovascular disease and its activity against Severe Acute Respiratory Syndrome (SARS). Option D: It exerts activity against more resistant gram-negative bacilli such as Acinetobacter baumanii and Pseudomonas aeruginosa. " C 5702546 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@]2([C@H]3[C@H]4[C@]1([C@@H]5C=C(C(=O)[C@]5(CC(=C4)COC(=O)CC6=CC(=C(C=C6)O)OC)O)C)O[C@](O3)(O2)CC7=CC=CC=C7)C(=C)C Question about this molecule: How is the pharmacological activity of this molecule Option A: It exerts activity against more resistant gram-negative bacilli such as Acinetobacter baumanii and Pseudomonas aeruginosa. Option B: It activates the vanilloid receptor in a subpopulation of primary afferent sensory neurons involved in nociception. Option C: It carries some activity against protozoans, and has been used off-label in the treatment of toxoplasmosis, malaria, and babesiosis. Option D: It acts as a partial mu-opioid receptor agonist with a high affinity for the receptor, but lower intrinsic activity compared to other full mu-opioid agonists. " B 5364079 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC(=O)NC(=O)/C(=N/OC)/C#N Question about this molecule: How is the pharmacological activity of this molecule Option A: It exerts activity against more resistant gram-negative bacilli such as Acinetobacter baumanii and Pseudomonas aeruginosa. Option B: It is primarily active on fungi belonging to the Peronosporales order: Phytophthora, Plasmopara, and Peronospora. Option C: It has major activity against mycobacteria, commonly used in combination with other agents as therapy of tuberculosis. Option D: It carries some activity against protozoans, and has been used off-label in the treatment of toxoplasmosis, malaria, and babesiosis. " B 91731 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=NC(=C1Cl)NC2=C(C=C(C(=C2[N+](=O)[O-])Cl)C(F)(F)F)[N+](=O)[O-])C(F)(F)F Question about this molecule: How is the pharmacological activity of this molecule Option A: It has major activity against mycobacteria, commonly used in combination with other agents as therapy of tuberculosis. Option B: It displays broad-spectrum activity against fungi and also very low toxicity to mammals. Option C: It carries some activity against protozoans, and has been used off-label in the treatment of toxoplasmosis, malaria, and babesiosis. Option D: It carries activity against a broad range of pathogens including bacteria, yeasts, and viruses. " B 33613 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=C(C=C3)O)N)C(=O)O)C Question about this molecule: How is the pharmacological activity of this molecule Option A: It carries some activity against protozoans, and has been used off-label in the treatment of toxoplasmosis, malaria, and babesiosis. Option B: It has major activity against mycobacteria, commonly used in combination with other agents as therapy of tuberculosis. Option C: It exerts activity against more resistant gram-negative bacilli such as Acinetobacter baumanii and Pseudomonas aeruginosa. Option D: It has similar activity to penicillin and ampicillin, but leads to higher serum concentrations than ampicillin. " D 32798 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)O[C@@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)C)C(=O)CCl Question about this molecule: How is the pharmacological activity of this molecule Option A: It displays broad-spectrum activity against fungi and also very low toxicity to mammals. Option B: It carries some activity against protozoans, and has been used off-label in the treatment of toxoplasmosis, malaria, and babesiosis. Option C: It has demonstrated superior activity compared to fluocinonide. Option D: It has major activity against mycobacteria, commonly used in combination with other agents as therapy of tuberculosis. " C 49806720 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC1=CC2=C(C=C1N3CCC(CC3)N4CCOCC4)C(C5=C(C2=O)C6=C(N5)C=C(C=C6)C#N)(C)C Question about this molecule: How is the pharmacological activity of this molecule Option A: It is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor. Option B: It is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. Option C: It is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Option D: It selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. " D 37768 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1NC(=O)[C@H](CCN)O)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)N)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CN)O)O)O)N Question about this molecule: How is the pharmacological activity of this molecule Option A: It exerts activity against more resistant gram-negative bacilli such as Acinetobacter baumanii and Pseudomonas aeruginosa. Option B: It carries some activity against protozoans, and has been used off-label in the treatment of toxoplasmosis, malaria, and babesiosis. Option C: It is investigated for its use in treating cardiovascular disease and its activity against Severe Acute Respiratory Syndrome (SARS). Option D: It has major activity against mycobacteria, commonly used in combination with other agents as therapy of tuberculosis. " A 5904 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)CC3=CC=CC=C3)C(=O)O)C Question about this molecule: How is the pharmacological activity of this molecule Option A: It is less active against most gram-positive organisms. Option B: It has greater activity against Gram negative bacteria. Option C: It has limited activity against gram negative organisms. Option D: It displays broad-spectrum activity against fungi and also very low toxicity to mammals. " C 2578 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCl)NC(=O)N(CCCl)N=O Question about this molecule: How is the pharmacological activity of this molecule Option A: It has activity toward diverse solid and hematopoietic tumors. Option B: It has activity against methicillin-resistant Staphylococcus aureus. Option C: It has major activity against mycobacteria, commonly used in combination with other agents as therapy of tuberculosis. Option D: It is a cell-cycle phase nonspecific alkylating antineoplastic agent. " D 29327 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO)O)O)N=O Question about this molecule: How is the pharmacological activity of this molecule Option A: It forms methylcarbonium ions, which alkylate or bind with many intracellular molecular structures including nucleic acids. Option B: It has activity against the Coronaviridae family, leading to considerable interest in it as a possible treatment for COVID-19. Option C: It has activity toward diverse solid and hematopoietic tumors. Option D: It has major activity against mycobacteria, commonly used in combination with other agents as therapy of tuberculosis. " A 5568 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)C(F)(F)F Question about this molecule: How is the pharmacological activity of this molecule Option A: It binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. Option B: It activates the vanilloid receptor in a subpopulation of primary afferent sensory neurons involved in nociception. Option C: It exerts activity against more resistant gram-negative bacilli such as Acinetobacter baumanii and Pseudomonas aeruginosa. Option D: It acts as a partial mu-opioid receptor agonist with a high affinity for the receptor, but lower intrinsic activity compared to other full mu-opioid agonists. " A 10288191 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO Question about this molecule: How is the pharmacological activity of this molecule Option A: It is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor. Option B: It acts as a partial mu-opioid receptor agonist with a high affinity for the receptor, but lower intrinsic activity compared to other full mu-opioid agonists. Option C: It exerts activity against more resistant gram-negative bacilli such as Acinetobacter baumanii and Pseudomonas aeruginosa. Option D: It activates the vanilloid receptor in a subpopulation of primary afferent sensory neurons involved in nociception. " A 3845 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=O)C=C(N2)C(=O)O Question about this molecule: How is the pharmacological activity of this molecule Option A: It carries activity against a broad range of pathogens including bacteria, yeasts, and viruses. Option B: It shows a slow and progressive enhancement during maturation and ageing. Option C: It has activity against the Coronaviridae family, leading to considerable interest in it as a possible treatment for COVID-19. Option D: It displays broad-spectrum activity against fungi and also very low toxicity to mammals. " B 280 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)=O Question about this molecule: What is the physical state of this molecule? Option A: It is a liquid at room temperature. Option B: It is a gas at room temperature and pressure. Option C: It is a viscous liquid at room temperature. Option D: It is a colorless liquid at room temperature. " B 7961 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)Br Question about this molecule: What is the physical state of this molecule? Option A: It is a clear colorless liquid. Option B: It appears as a clear colorless liquid. Option C: It is a colorless liquid at room temperature. Option D: It is a liquid at room temperature. " D 1030 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CO)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It is a liquid. Option C: It appears as a liquid. Option D: It is a clear liquid. " B 10442 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CO)CO Question about this molecule: What is the physical state of this molecule? Option A: It appears as a liquid. Option B: It appears as a colorless liquid. Option C: It is a clear liquid. Option D: It is a liquid. " D 5271566 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)/C=C\\C(=O)OCC Question about this molecule: What is the physical state of this molecule? Option A: It is a liquid at room temperature. Option B: It is a colorless liquid at room temperature. Option C: It is a clear colorless liquid. Option D: It appears as a clear colorless liquid. " A 7865 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC=O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless, mobile, flammable liquid. Option B: It is a low-boiling colorless, flammable liquid. Option C: It is a light, volatile, colourless, flammable, poisonous liquid. Option D: It is a colorless, flammable liquid. " B 151080 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC1 Question about this molecule: What is the physical state of this molecule? Option A: It is a viscous liquid at room temperature. Option B: It is a liquid at room temperature. Option C: It is a gas at room temperature and pressure. Option D: It is a colorless liquid at room temperature. " C 6740 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CC=C1Cl)[N+](=O)[O-] Question about this molecule: What is the physical state of this molecule? Option A: It is a low-melting solid. Option B: It appears as a colorless crystalline solid. Option C: It is a low-melting, crystalline solid. Option D: It is a colorless crystalline solid. " A 7248 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)N)C Question about this molecule: What is the physical state of this molecule? Option A: It is a low-melting solid. Option B: It is a low-melting, crystalline solid. Option C: It is a colorless crystalline solid. Option D: It appears as a colorless crystalline solid. " B 8491 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)[N+](=O)[O-])Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a pale yellow to tan crystalline powder. Option B: It is a colorless to pale yellow crystalline solid. Option C: It occurs as a colorless to pale yellow solid. Option D: It is a pale yellow crystalline compound. " D 8064 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCO)CO Question about this molecule: What is the physical state of this molecule? Option A: It is a viscous liquid at room temperature. Option B: It is a colorless viscous oily liquid. Option C: It is a clear colorless viscous liquid. Option D: It is a viscous oily liquid. " A 12021 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)OC Question about this molecule: What is the physical state of this molecule? Option A: It is a flammable liquid. Option B: It is a colorless flammable gas. Option C: It is a colorless, flammable liquid. Option D: It is a colorless, mobile, flammable liquid. " A 542762 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)O)(Cl)Br Question about this molecule: What is the physical state of this molecule? Option A: It is a hygroscopic crystalline solid. Option B: It is a colorless crystalline solid. Option C: It appears as a colorless crystalline solid. Option D: It is a solution of a colorless crystalline solid. " A 8060 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCN Question about this molecule: What is the physical state of this molecule? Option A: It appears as a liquid. Option B: It appears as a colorless liquid. Option C: It is a liquid. Option D: It is a clear liquid. " C 688020 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(C1=CC=CC=C1C)C(=O)/C=C/C Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless or slightly yellow oily liquid. Option B: It is a colorless to pale yellow oily liquid. Option C: It is a colourless or pale yellow oily liquid. Option D: It is a pale yellow oily liquid. " C 7289 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(CCl)O)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid at room temperature. Option B: It is a liquid at room temperature. Option C: It appears as a clear colorless liquid. Option D: It is a clear colorless liquid. " B 6344 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a dense, non-flammable liquid. Option B: It is a low-boiling colorless, flammable liquid. Option C: It is a colorless, flammable liquid. Option D: It is a colorless, mobile, flammable liquid. " A 24823 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-][O+]=O Question about this molecule: What is the physical state of this molecule? Option A: It is a gas. Option B: It appears as a colorless liquid. Option C: It is a colorless gas. Option D: It is a colorless liquid. " A 517165 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)[O-].[NH4+] Question about this molecule: What is the physical state of this molecule? Option A: It is a deliquescent white crystalline solid. Option B: It is a fine white crystalline solid. Option C: It is a colorless to white crystalline solid. Option D: It is a white crystalline solid. " A 82050 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Li+].[Br-] Question about this molecule: What is the physical state of this molecule? Option A: It appears as colorless crystals. Option B: It appears as white crystals. Option C: It forms cubic crystals. Option D: It appears as golden crystals. " C 6419 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)(Cl)Cl)(Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a low-boiling colorless, flammable liquid. Option B: It is a high-boiling liquid. Option C: It appears as a colorless low-boiling liquid. Option D: It is a colorless, mobile, flammable liquid. " B 62662 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O.O.O.O.O.O.O.[O-]S(=O)(=O)[O-].[Fe+2] Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless crystalline solid. Option B: It is a colorless crystalline solid. Option C: It is a crystalline solid. Option D: It is a solid. " D 8029 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=COC=C1 Question about this molecule: What is the physical state of this molecule? Option A: It is a liquid. Option B: It is a clear liquid. Option C: It appears as a colorless liquid. Option D: It appears as a liquid. " A 12397 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCCCCO Question about this molecule: What is the physical state of this molecule? Option A: It floats on water. Option B: It appears as a colorless liquid. Option C: It sinks and mixes with water. Option D: It is a colorless liquid. " A 7762 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(=O)OCC Question about this molecule: What is the physical state of this molecule? Option A: It is a liquid. Option B: It is a clear liquid. Option C: It appears as a liquid. Option D: It appears as a colorless liquid. " A 8255 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=C)C Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid. Option B: It appears as a colorless liquid. Option C: It is a gas. Option D: It is a colorless gas. " C 8025 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC=O Question about this molecule: What is the physical state of this molecule? Option A: It is a gas. Option B: It is a colorless liquid. Option C: It is a colorless gas. Option D: It appears as a colorless liquid. " A 5280343 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O Question about this molecule: What is the physical state of this molecule? Option A: It is a solid. Option B: It is a crystalline solid. Option C: It is a colorless crystalline solid. Option D: It appears as a colorless crystalline solid. " A 280 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)=O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless gas. Option B: It is a gas. Option C: It is a colorless liquid. Option D: It appears as a colorless liquid. " B 9570092 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(/C=N/O)SC Question about this molecule: What is the physical state of this molecule? Option A: It appears as a liquid. Option B: It is a clear liquid. Option C: It is a liquid. Option D: It appears as a colorless liquid. " C 10187 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC2=CC3=C(C(=CC=C3)O)C(=C2C(=C1)O)O Question about this molecule: What is the physical state of this molecule? Option A: It is a crystalline solid. Option B: It is a colorless crystalline solid. Option C: It is a solid. Option D: It appears as a colorless crystalline solid. " C 9731 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1N)F Question about this molecule: What is the physical state of this molecule? Option A: It appears as a liquid. Option B: It is a liquid. Option C: It appears as a colorless liquid. Option D: It is a clear liquid. " B 2268 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=S)(OC)SCN1C(=O)C2=CC=CC=C2N=N1 Question about this molecule: What is the physical state of this molecule? Option A: It is a solid. Option B: It is a colorless crystalline solid. Option C: It is a crystalline solid. Option D: It appears as a colorless crystalline solid. " A 10907 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CC(C)(C)C Question about this molecule: What is the physical state of this molecule? Option A: It appears as a liquid. Option B: It appears as a colorless liquid. Option C: It is a liquid. Option D: It is a clear liquid. " C 13529 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(F)(F)F)(C(F)(F)F)O Question about this molecule: What is the physical state of this molecule? Option A: It is a clear liquid. Option B: It appears as a colorless liquid. Option C: It appears as a liquid. Option D: It is a liquid. " D 5816 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC[C@@H](C1=CC(=C(C=C1)O)O)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a liquid. Option B: It is a liquid. Option C: It is a clear liquid. Option D: It appears as a colorless liquid. " B 2719 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl Question about this molecule: What is the physical state of this molecule? Option A: It appears as a liquid. Option B: It appears as a colorless liquid. Option C: It is a liquid. Option D: It is a clear liquid. " C 6328 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CI Question about this molecule: What is the physical state of this molecule? Option A: It is a liquid. Option B: It is a clear liquid. Option C: It appears as a liquid. Option D: It appears as a colorless liquid. " A 12901 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=S)(OC)SCN1C(=O)C2=CC=CC=C2C1=O Question about this molecule: What is the physical state of this molecule? Option A: It is a solid. Option B: It is a crystalline solid. Option C: It appears as a colorless crystalline solid. Option D: It is a colorless crystalline solid. " A 10967 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(OCCl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid. Option B: It is a clear liquid. Option C: It appears as a colorless liquid. Option D: It is a dense colorless liquid. " B 6569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)C Question about this molecule: What is the physical state of this molecule? Option A: It is a clear colorless liquid. Option B: It appears as a colorless liquid. Option C: It is a dense colorless liquid. Option D: It is a colorless liquid. " D 1486 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1Cl)Cl)OCC(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a dark brown liquid. Option B: It is a colorless to light yellow liquid. Option C: It appears as a clear brown to black liquid. Option D: It is a colorless to dark red liquid. " C 6278 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(Cl)(Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid. Option B: It appears as a colorless liquid. Option C: It is a dense colorless liquid. Option D: It is a clear colorless liquid. " A 297 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid. Option B: It is a gas. Option C: It is a colorless gas. Option D: It appears as a colorless liquid. " C 6589 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C(C)C Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It appears as a clear colorless liquid. Option C: It is a clear colorless liquid. Option D: It is a dense colorless liquid. " B 227 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)C(=O)O)N Question about this molecule: What is the physical state of this molecule? Option A: It appears as a white to pale-yellow or tan crystalline powder. Option B: It is an odorless white to light-yellow crystalline powder. Option C: It is an odorless white to off-white crystalline powder. Option D: It is an odorless white to slightly yellow crystalline powder. " A 8470 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: B(OC)(OC)OC Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless watery liquid. Option B: It is a colorless oily liquid. Option C: It appears as a water-white liquid. Option D: It is a water-white mobile liquid. " C 3120 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C(=O)NC1=CC(=C(C=C1)Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a white crystalline, wettable powder. Option B: It is a white crystalline powder. Option C: It appears as a white crystalline, odorless powder. Option D: It is a wettable powder. " D 11443 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)N=C=O)N=C=O Question about this molecule: What is the physical state of this molecule? Option A: It is a clear, colorless to pale yellow liquid. Option B: It is a colorless to pale yellow oily liquid. Option C: The mixture is a clear, pale yellow liquid. Option D: It appears as a colorless to pale yellow liquid. " C 10750 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC2=NC3=C(C=CC(=C3)N)C=C21)N.Cl.Cl Question about this molecule: What is the physical state of this molecule? Option A: It is an odorless white to off-white microcrystalline powder. Option B: It is an odorless white to off-white crystalline powder. Option C: It is an orange-red to brown-red crystalline powder. Option D: It is a white to off-white or faintly yellow crystalline powder. " C 957 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCO Question about this molecule: What is the physical state of this molecule? Option A: It is a dense colorless liquid. Option B: It appears as a colorless liquid. Option C: It is a clear colorless liquid. Option D: It appears as a clear colorless liquid. " D 7903 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC[N+](=O)[O-] Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless, oily liquid. Option B: It appears as a colorless, fuming oily liquid. Option C: It appears as a colorless oily liquid. Option D: It is a colorless oily liquid. " C 8103 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCO Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless gas. Option B: It appears as a colorless liquid. Option C: It is a gas. Option D: It is a colorless liquid. " C 6945 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)[N+](=O)[O-])Cl Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless crystalline solid. Option B: It is a colorless crystalline solid. Option C: It is a solid. Option D: It is a crystalline solid. " C 6184 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC=O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid. Option B: It appears as a colorless liquid. Option C: It is a gas. Option D: It is a colorless gas. " C 6359 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)(Cl)Br Question about this molecule: What is the physical state of this molecule? Option A: It is a clear liquid. Option B: It appears as a liquid. Option C: It appears as a colorless liquid. Option D: It is a liquid. " D 9703 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NC(=O)C1=CC=C(C=C1)CNNC.Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless crystalline solid. Option B: It is a solid. Option C: It appears as a colorless crystalline solid. Option D: It is a crystalline solid. " B 10129889 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Li+].[N+](=O)([O-])[O-] Question about this molecule: What is the physical state of this molecule? Option A: It is a crystalline solid. Option B: It appears as a colorless crystalline solid. Option C: It is a solid. Option D: It is a colorless crystalline solid. " C 7845 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC=C Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid. Option B: It is a colorless gas. Option C: It is a gas. Option D: It appears as a colorless liquid. " C 31260 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CCO Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It is a liquid. Option C: It is a clear liquid. Option D: It appears as a liquid. " B 516892 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(O)[O-].[Na+] Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless crystalline solid. Option B: It is a solid. Option C: It is a crystalline solid. Option D: It appears as a colorless crystalline solid. " B 441373 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)C2=C3C=C(C(=O)C=C3OC4=C(C(=C(C=C24)Br)[O-])[Hg])Br)C(=O)[O-].O.[Na+].[Na+] Question about this molecule: What is the physical state of this molecule? Option A: It is a liquid. Option B: It appears as a liquid. Option C: It is a clear liquid. Option D: It appears as a colorless liquid. " A 700 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CO)N Question about this molecule: What is the physical state of this molecule? Option A: It is a liquid. Option B: It is a clear liquid. Option C: It appears as a liquid. Option D: It appears as a colorless liquid. " A 6051 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)N=NC2=CC=C(C=C2)N Question about this molecule: What is the physical state of this molecule? Option A: It is a crystalline solid. Option B: It appears as a colorless crystalline solid. Option C: It is a colorless crystalline solid. Option D: It is a solid. " D 25514 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [NH4+].[Br-] Question about this molecule: What is the physical state of this molecule? Option A: It is a solid. Option B: It is a crystalline solid. Option C: It is a colorless crystalline solid. Option D: It appears as a colorless crystalline solid. " A 145068 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N]=O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless gas. Option B: It is a gas. Option C: It appears as a colorless liquid. Option D: It is a colorless liquid. " B 379 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCC(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a liquid. Option B: It is a clear liquid. Option C: It appears as a colorless liquid. Option D: It is a liquid. " D 656671 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]S(=O)S(=O)(=O)[O-].[Na+].[Na+] Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless crystalline solid. Option B: It is a colorless crystalline solid. Option C: It is a crystalline solid. Option D: It is a solid. " D 9625 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(F)(F)(Cl)Br Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless gas. Option B: It is a gas. Option C: It is a colorless liquid. Option D: It appears as a colorless liquid. " B 6277 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)[O-].CC(=O)[O-].[Co+2] Question about this molecule: What is the physical state of this molecule? Option A: It is a solid. Option B: It appears as a colorless crystalline solid. Option C: It is a colorless crystalline solid. Option D: It is a crystalline solid. " A 7344 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C(C)O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless gas. Option B: It is a gas. Option C: It appears as a colorless liquid. Option D: It is a colorless liquid. " B 9550 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=[N+]=[N-] Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid. Option B: It is a colorless gas. Option C: It appears as a colorless liquid. Option D: It is a gas. " D 6658 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=C)C(=O)OC Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid. Option B: It is a colorless gas. Option C: It appears as a colorless liquid. Option D: It is a gas. " D 335 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1O Question about this molecule: What is the physical state of this molecule? Option A: It is a clear liquid. Option B: It appears as a liquid. Option C: It is a liquid. Option D: It appears as a colorless liquid. " C 8461 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: What is the physical state of this molecule? Option A: It is a crystalline solid. Option B: It is a solid. Option C: It appears as a colorless crystalline solid. Option D: It is a colorless crystalline solid. " B 24463 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O.O.O.O.O.[O-]S(=O)(=O)[O-].[Cu+2] Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless crystalline solid. Option B: It is a crystalline solid. Option C: It appears as a colorless crystalline solid. Option D: It is a solid. " D 8058 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC Question about this molecule: What is the physical state of this molecule? Option A: It appears as a liquid. Option B: It is a liquid. Option C: It appears as a colorless liquid. Option D: It is a clear liquid. " B 17358 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: FS(F)(F)(F)(F)F Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless gas. Option B: It is a colorless liquid. Option C: It appears as a colorless liquid. Option D: It is a gas. " D 1045 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCN)CN Question about this molecule: What is the physical state of this molecule? Option A: It is a crystalline solid. Option B: It is a colorless crystalline solid. Option C: It is a solid. Option D: It appears as a colorless crystalline solid. " C 7945 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)CC(C)C Question about this molecule: What is the physical state of this molecule? Option A: It is a gas. Option B: It is a colorless gas. Option C: It is a colorless liquid. Option D: It appears as a colorless liquid. " A 179 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C(=O)C)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a liquid. Option B: It appears as a colorless liquid. Option C: It is a liquid. Option D: It is a clear liquid. " C 7367 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(Cl)(Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It appears as a liquid. Option B: It is a liquid. Option C: It is a clear liquid. Option D: It appears as a colorless liquid. " B 6694 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)C1=CC2=C(C=C1)C(=C3C=CC(=[N+](CC)CC)C=C3O2)C4=CC=CC=C4C(=O)O.[Cl-] Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless crystalline solid. Option B: It is a colorless crystalline solid. Option C: It is a crystalline solid. Option D: It is a solid. " D 6560 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CO Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid. Option B: It is a colorless gas. Option C: It is a gas. Option D: It appears as a colorless liquid. " C 10903 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless gas. Option B: It appears as a colorless liquid. Option C: It is a gas. Option D: It is a colorless liquid. " C 674 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC Question about this molecule: What is the physical state of this molecule? Option A: It is a liquid. Option B: It appears as a liquid. Option C: It appears as a colorless liquid. Option D: It is a clear liquid. " A 10208 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=CC=C3O Question about this molecule: What is the physical state of this molecule? Option A: It is a white crystalline powder. Option B: It is a solution in concentrated sulfuric acid. Option C: It is a white crystalline organic acid. Option D: It is a colorless syrupy acid. " B 444305 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C@@H]([C@H](C(=O)O)O)(C(=O)O)O Question about this molecule: What is the physical state of this molecule? Option A: It is a white crystalline powder. Option B: It is a white crystalline solid. Option C: It is a white crystalline organic acid. Option D: It is a fine white crystalline solid. " C 6584 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)OC Question about this molecule: What is the physical state of this molecule? Option A: It is a tan liquid. Option B: It appears as a liquid. Option C: It is a liquid. Option D: It is a vapor. " D 4130 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=S)(OC)OC1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: What is the physical state of this molecule? Option A: It appears as a liquid. Option B: It is a liquid. Option C: It is a clear liquid. Option D: It is a tan liquid. " D 6579 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC(=O)N Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to yellow crystalline solid. Option B: It is a solution of a colorless crystalline solid. Option C: It is a colorless crystalline solid. Option D: It appears as a colorless crystalline solid. " B 8667 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCN(CC1=CC=CS1)C2=CC=CC=N2.Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a fine white crystalline solid. Option B: It is a white crystalline powder. Option C: It is a white crystalline solid. Option D: It is a white crystalline powder or solid. " D 5975 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C-]#N Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless and highly volatile liquid. Option B: It is a colorless volatile liquid. Option C: It is a clear colorless highly volatile liquid. Option D: It appears as a colorless volatile liquid. " A 4650 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=O)C=CC1=O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to yellow crystalline solid. Option B: It is a colorless to pale yellow crystalline solid. Option C: It is a yellowish-colored crystalline solid. Option D: It appears as a yellowish white crystalline solid. " C 934 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Ni+2] Question about this molecule: What is the physical state of this molecule? Option A: It is a solid. Option B: It is a colorless crystalline solid. Option C: It is a crystalline solid. Option D: It appears as a colorless crystalline solid. " A 1176 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(N)N Question about this molecule: What is the physical state of this molecule? Option A: It is an odorless white to slightly yellow crystalline powder. Option B: It is an odorless white to cream colored crystalline powder. Option C: It is an odorless white to light-yellow crystalline powder. Option D: It is solid odorless white crystals or pellets. " D 6568 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C)O Question about this molecule: What is the physical state of this molecule? Option A: It is a dense colorless liquid. Option B: It appears as a colorless liquid. Option C: It is a clear colorless liquid. Option D: It appears as a clear colorless liquid. " C 938 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CN=C1)C(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It is a dense colorless liquid. Option B: It appears as a colorless liquid. Option C: It is a colorless liquid. Option D: It is a solution. " D 11294 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C1=CC=C(C=C1)C(=C2C=CC(=[N+](C)C)C=C2)C3=CC=CC=C3.[Cl-] Question about this molecule: What is the physical state of this molecule? Option A: It is a yellow-orange crystalline solid. Option B: It is a yellow-green crystalline solid. Option C: It is a yellowish-colored crystalline solid. Option D: It is a blue-green solution. " D 21694 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC2=C3C(=C1)C=CC4=C(C=CC(=C43)C=C2)[N+](=O)[O-] Question about this molecule: What is the physical state of this molecule? Option A: It is yellow needles or prisms. Option B: It appears as colorless crystals or white powder or chunky white solid. Option C: It is solid odorless white crystals or pellets. Option D: It appears as needles or a white solid. " A 1923 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC2=C(C(=C1)O)N=CC=C2 Question about this molecule: What is the physical state of this molecule? Option A: It is a white to off-white or faintly yellow crystalline powder. Option B: It is an odorless white to slightly yellow crystalline powder. Option C: It is an odorless white to off-white microcrystalline powder. Option D: It is an odorless white to off-white crystalline powder. " A 26077 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Be+2].[O-]S(=O)(=O)[O-] Question about this molecule: What is the physical state of this molecule? Option A: It is a rare and lustrous silvery-white metal. Option B: It is a silvery-white liquid. Option C: It is a hard, silvery-white metal. Option D: It is a lightweight alkaline earth metal. " D 16684434 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[Hg]SC1=CC=CC=C1C(=O)[O-].[Na+] Question about this molecule: What is the physical state of this molecule? Option A: It appears as a liquid. Option B: It is a clear liquid. Option C: It appears as a colorless liquid. Option D: It is a liquid. " D 2723949 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=S)N Question about this molecule: What is the physical state of this molecule? Option A: It appears as white crystals. Option B: It appears as golden crystals. Option C: It appears as colorless monoclinic crystals. Option D: It appears as colorless crystals. " A 6366 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=C(Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid. Option B: It is a clear colorless liquid. Option C: It appears as a colorless liquid. Option D: It is a dense colorless liquid. " A 439846 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](CO)O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless, clear, oily liquid. Option B: It is a clear, colorless, slightly syrupy liquid at room temperature. Option C: It is a clear, colorless, viscous organic solvent. Option D: It is a clear, colorless liquid with a pleasant odor. " C 1549517 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCNC(=S)N Question about this molecule: What is the physical state of this molecule? Option A: It is a white crystalline powder. Option B: It is a fine white crystalline solid. Option C: It is a white crystalline powder or solid. Option D: It is a white crystalline solid. " D 7923 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=O)OC1=O Question about this molecule: What is the physical state of this molecule? Option A: It is a solution of a colorless crystalline solid. Option B: It appears as a colorless crystalline solid. Option C: It is a colorless crystalline solid. Option D: It can be shipped as both a solid and in the molten state. " D 2230 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CCC=C(C1)C(=O)OC Question about this molecule: What is the physical state of this molecule? Option A: It is an oily liquid. Option B: It is a colorless oily liquid. Option C: It is an oily yellow liquid. Option D: It appears as an oily straw yellow clear liquid. " A 9321 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: NN Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless, oily liquid. Option B: It appears as a colorless, fuming oily liquid. Option C: It is a colorless oily liquid. Option D: It appears as a colorless oily liquid. " B 114829 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@H](OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless crystalline solid. Option B: It is a crystalline solid. Option C: It appears as a colorless crystalline solid. Option D: It is a solid. " D 7720 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(CC)CO Question about this molecule: What is the physical state of this molecule? Option A: It appears as a dark brown liquid. Option B: It is a colorless to light yellow liquid. Option C: It appears as a colorless to light yellow liquid. Option D: It is a colorless to dark red liquid. " A 6296 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CC(=C1)C2=CC(=C(C=C2)N=NC3=C(C4=C(C=C(C=C4C=C3S(=O)(=O)[O-])S(=O)(=O)[O-])N)O)C)N=NC5=C(C6=C(C=C(C=C6C=C5S(=O)(=O)[O-])S(=O)(=O)[O-])N)O.[Na+].[Na+].[Na+].[Na+] Question about this molecule: What is the physical state of this molecule? Option A: It is a bluish-gray to dark blue powder. Option B: It is an odorless dark purple to blackish-brown powder. Option C: It is a white to very pale yellow crystalline powder. Option D: It is a deep purple to dark blue microcrystalline powder. " A 5758 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C(=C1)Cl)C(=O)O)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a solution of a colorless crystalline solid. Option B: It appears as a colorless crystalline solid. Option C: It is a colorless crystalline solid. Option D: It appears as needles or a white solid. " D 18430 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C(O1)CBr Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless volatile liquid. Option B: It is a colorless volatile liquid. Option C: It is a clear colorless highly volatile liquid. Option D: It appears as a colorless to yellow volatile liquid. " B 4875 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [K+].[I-] Question about this molecule: What is the physical state of this molecule? Option A: It floats on water. Option B: It sinks and mixes with water. Option C: It is a colorless liquid. Option D: It appears as a colorless liquid. " B 3017 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OC1=NC(=NC(=C1)C)C(C)C Question about this molecule: What is the physical state of this molecule? Option A: It appears as a clear colorless to yellow liquid with a bitter almond odor. Option B: It is a clear colorless oily liquid with a pleasant odor. Option C: It is a colorless liquid with a mild pleasant odor. Option D: It is a colorless and practically odorless oil. " D 439194 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@H](C(=O)O)O)O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless syrupy acid. Option B: It appears as a colorless oily liquid. Option C: It is a clear, colorless syrupy liquid. Option D: It appears as a colorless to yellow syrupy liquid. " A 7342 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C(C)C Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless to yellow volatile liquid. Option B: It appears as a colorless volatile liquid. Option C: It is a clear colorless highly volatile liquid. Option D: It is a colorless volatile liquid. " B 1049 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=NC=C1 Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It is a clear colorless liquid. Option C: It is a dense colorless liquid. Option D: It is a colorless liquid. " D 7641 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(CC)COC(=O)CCCCC(=O)OCC(CC)CCCC Question about this molecule: What is the physical state of this molecule? Option A: It is a clear colorless liquid. Option B: It appears as a clear colorless liquid. Option C: It is a colorless to straw-colored liquid. Option D: It is a colorless to straw colored liquid. " C 15413 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)OC Question about this molecule: What is the physical state of this molecule? Option A: It is a flammable liquid. Option B: It is a colorless flammable gas. Option C: It is a colorless, flammable liquid. Option D: It is a colorless, mobile, flammable liquid. " A 2882 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC2=C(C(=C1)OCC(COC3=CC=CC4=C3C(=O)C=C(O4)C(=O)O)O)C(=O)C=C(O2)C(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless crystalline solid. Option B: It is a colorless crystalline solid. Option C: It is a crystalline solid. Option D: It is a solid. " D 6575 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=C(Cl)Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid. Option B: It appears as a colorless liquid. Option C: It is a dense colorless liquid. Option D: It is a clear liquid. " D 991 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OC1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless to light yellow liquid. Option B: It is a colorless to light-brown crystalline material. Option C: It is a yellow-to-brown liquid. Option D: It is a colorless to light yellow liquid. " C 6212 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)(Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a dense colorless liquid. Option B: It appears as a colorless liquid. Option C: It is a colorless liquid. Option D: It is a clear colorless liquid. " C 7501 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC1=CC=CC=C1 Question about this molecule: What is the physical state of this molecule? Option A: It is a dense colorless liquid. Option B: It is a clear colorless liquid. Option C: It appears as a colorless liquid. Option D: It is a colorless liquid. " D 7902 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCO Question about this molecule: What is the physical state of this molecule? Option A: It appears as a clear colorless liquid. Option B: It appears as a colorless liquid. Option C: It is a clear colorless liquid. Option D: It is a dense colorless liquid. " A 11167 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN=C=S Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid. Option B: It appears as a colorless liquid. Option C: It is a dense colorless liquid. Option D: It is a clear colorless liquid. " B 6228 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C=O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a water-white liquid. Option B: It is a water-white mobile liquid. Option C: It is a colorless watery liquid. Option D: It is a colorless oily liquid. " A 2969 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCC(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It is a white crystalline solid. Option B: It is a white crystalline powder. Option C: It is a fine white crystalline solid. Option D: It is a white crystalline powder or solid. " A 24874 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C)N Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid. Option B: It is a white liquid. Option C: It appears as a colorless liquid. Option D: It appears as a white liquid. " B 36400 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C=C1Cl)Cl)C2=CC(=CC(=C2)Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a viscous liquid at room temperature. Option B: It is a viscous oily liquid. Option C: It is a colorless viscous oily liquid. Option D: It is a clear colorless viscous liquid. " B 12388 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCC Question about this molecule: What is the physical state of this molecule? Option A: It is an oily yellow liquid. Option B: It appears as an oily straw yellow clear liquid. Option C: It is an oily liquid. Option D: It is a colorless oily liquid. " B 7289 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(CCl)O)Cl Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless, slightly viscous liquid. Option B: It is a colorless to slightly yellow viscous liquid. Option C: It is a slightly yellow viscous liquid. Option D: It is a colorless to yellow slightly viscous liquid. " D 6407 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)C(Cl)(Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless oily liquid. Option B: It appears as a colorless oily liquid. Option C: It appears as a colorless, fuming oily liquid. Option D: It appears as a colorless, oily liquid. " B 8154 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCCCCC[N+](C)(C)C.[Cl-] Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless to pale yellow liquid. Option B: It is a colorless to pale yellow crystalline solid. Option C: It is a clear, colorless to pale yellow liquid. Option D: It occurs as a colorless to pale yellow solid. " A 6397 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[Si](C)(C)Cl Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless, fuming oily liquid. Option B: It appears as a colorless, oily liquid. Option C: It appears as a colorless fuming liquid. Option D: It appears as a colorless oily liquid. " C 8180 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCC(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid. Option B: It appears as a colorless liquid. Option C: It floats on water. Option D: It sinks and mixes with water. " C 12986 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(=C)C Question about this molecule: What is the physical state of this molecule? Option A: It floats on water. Option B: It sinks and mixes with water. Option C: It appears as a colorless liquid. Option D: It is a colorless liquid. " A 31268 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCNC1 Question about this molecule: What is the physical state of this molecule? Option A: It appears as a liquid. Option B: It is a vapor. Option C: It is a liquid. Option D: It is a tan liquid. " B 6629 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C1=CC=CC=C1)OO Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to light yellow liquid. Option B: It appears as a colorless to pale yellow liquid. Option C: It is a clear colorless to light yellow liquid. Option D: It appears as a colorless to light yellow liquid. " D 4096 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=O)(N)SC Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless crystalline solid. Option B: It is a solution of a colorless crystalline solid. Option C: It is a colorless crystalline solid. Option D: It is a crystalline solid. " D 7175 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCOC(=O)C1=CC=C(C=C1)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless to light tan crystalline powder or solid. Option B: It appears as colorless crystals or light brown powder. Option C: It appears as brown waxy solid or colorless solid. Option D: It appears as colorless crystals or white powder or chunky white solid. " D 24261 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=[Si]=O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It is the non-crystalline form. Option C: It is a colorless liquid. Option D: It is a solution. " B 5743 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C Question about this molecule: What is the physical state of this molecule? Option A: It is an odorless white to off-white microcrystalline powder. Option B: It is an odorless white to light-yellow crystalline powder. Option C: It is an odorless white to slightly yellow crystalline powder. Option D: It is an odorless white to off-white crystalline powder. " D 8857 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C Question about this molecule: What is the physical state of this molecule? Option A: It is a dense colorless liquid. Option B: It appears as a colorless liquid. Option C: It appears as a clear colorless liquid. Option D: It is a clear colorless liquid. " C 2756 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(N=CN1)CSCCNC(=NC)NC#N Question about this molecule: What is the physical state of this molecule? Option A: It appears as colorless monoclinic crystals. Option B: It appears as white crystals. Option C: It appears as golden crystals. Option D: It appears as colorless crystals. " B 16666 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1CC[C@H]([C@@H](C1)O)C(C)C Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless, oily liquid. Option B: It appears as a colorless oily liquid. Option C: It is a colorless oily liquid. Option D: It is a waxy, crystalline substance. " D 7967 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(=O)CC1 Question about this molecule: What is the physical state of this molecule? Option A: It is a clear, colorless to pale yellow liquid. Option B: It appears as a colorless to pale yellow liquid. Option C: It occurs as a colorless to pale yellow solid. Option D: It is a colorless to pale yellow crystalline solid. " B 25000 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N+](=O)([O-])[O-].[N+](=O)([O-])[O-].[Co+2] Question about this molecule: What is the physical state of this molecule? Option A: It floats on water. Option B: It is a colorless liquid. Option C: It sinks and mixes with water. Option D: It appears as a colorless liquid. " C 853433 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C=C/C1=CC(=C(C=C1)O)OC Question about this molecule: What is the physical state of this molecule? Option A: It is a pale yellow oily liquid. Option B: It is a colorless to pale yellow oily liquid. Option C: It is a colorless or slightly yellow oily liquid. Option D: It appears as a yellow oily liquid. " A 7955 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=NC(=NC(=N1)N)N)N Question about this molecule: What is the physical state of this molecule? Option A: It appears as colorless to white monoclinic crystals or prisms or white powder. Option B: It appears as white or yellowish crystals or beige powder. Option C: It appears as white to yellowish-white fine crystalline powder. Option D: It appears as colorless crystals or white powder or chunky white solid. " A 61460 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O.O.O.O.O.O.O.O[As](=O)([O-])[O-].[Na+].[Na+] Question about this molecule: What is the physical state of this molecule? Option A: It appears as a clear colorless aqueous solution. Option B: It is a colorless crystalline solid. Option C: It is a solution of a colorless crystalline solid. Option D: It is an aqueous solution. " D 8038 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)COC(=O)C Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It is a clear colorless liquid. Option C: It appears as a clear colorless liquid. Option D: It is a dense colorless liquid. " B 24726 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(/C=C/Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a dense colorless liquid. Option B: It is a clear colorless liquid. Option C: It is a colorless liquid. Option D: It appears as a colorless liquid. " C 3039 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=O)(OC)OC=C(Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It is a clear colorless liquid. Option C: It is a colorless liquid. Option D: It is a dense colorless liquid. " D 31241 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(CC)C=O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a white liquid. Option B: It is a colorless liquid. Option C: It appears as a colorless liquid. Option D: It is a white liquid. " D 7249 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)O)C Question about this molecule: What is the physical state of this molecule? Option A: It appears as colorless crystals or white powder or chunky white solid. Option B: It is a white crystalline powder or solid. Option C: It appears as a colorless to light tan crystalline powder or solid. Option D: It appears as colorless crystals or light brown powder. " C 11883 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=C(C=C1)[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless to light yellow or brown liquid. Option B: It appears as a colorless to light yellow liquid. Option C: It appears as a yellow to red solid or heated liquid. Option D: It is a colorless to light yellow liquid. " C 995 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC3=CC=CC=C32 Question about this molecule: What is the physical state of this molecule? Option A: It appears as colorless monoclinic crystals. Option B: It appears as colorless crystals. Option C: It appears as golden crystals. Option D: It appears as white crystals. " A 3000605 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CNC(=S)S)NC(=S)S Question about this molecule: What is the physical state of this molecule? Option A: It is a crystalline solid. Option B: It is a colorless crystalline solid. Option C: It appears as a colorless crystalline solid. Option D: It is a solid. " D 6540 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOCCOP(=O)(OCCOCCCC)OCCOCCCC Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless, slightly viscous liquid. Option B: It is a colorless to slightly yellow viscous liquid. Option C: It is a colorless to yellow slightly viscous liquid. Option D: It is a slightly yellow viscous liquid. " D 787 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: NO Question about this molecule: What is the physical state of this molecule? Option A: It sinks and mixes with water. Option B: It is a colorless liquid. Option C: It appears as a colorless liquid. Option D: It floats on water. " A 8252 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC=C Question about this molecule: What is the physical state of this molecule? Option A: It is a gas. Option B: It is a colorless liquid. Option C: It is a colorless gas. Option D: It appears as a colorless liquid. " C 944 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N+](=O)(O)[O-] Question about this molecule: What is the physical state of this molecule? Option A: It appears as a pale yellow to reddish brown liquid. Option B: It appears as a colorless to light yellow liquid. Option C: It is a colorless to light yellow liquid. Option D: It appears as a colorless to light yellow or brown liquid. " A 3598 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is an odorless white to light-yellow crystalline powder. Option B: It appears as a white free-flowing odorless powder. Option C: It is an odorless white to off-white crystalline powder. Option D: It is an odorless white to off-white microcrystalline powder. " B 8418 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C=C3C=CC=CC3=CC2=C1 Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to yellow crystalline solid. Option B: It is a white to tan solid. Option C: It is a white to yellow solid. Option D: It is a white to green solid. " C 443201 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)[C@H]([C@@H](COP(=O)(O)O)O)O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless crystalline solid. Option B: It is a crystalline solid. Option C: It appears as a colorless crystalline solid. Option D: It is a solid. " D 947 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: N#N Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid. Option B: It appears as a colorless liquid. Option C: It is a gas. Option D: It is a colorless gas. " C 6014 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C.Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a solid. Option B: It appears as a colorless crystalline solid. Option C: It is a colorless crystalline solid. Option D: It is a crystalline solid. " A 7837 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=C)C(=O)OCC1CO1 Question about this molecule: What is the physical state of this molecule? Option A: It is a clear liquid. Option B: It appears as a colorless liquid. Option C: It is a liquid. Option D: It appears as a liquid. " C 6338 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCl Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid. Option B: It is a colorless gas. Option C: It is a gas. Option D: It appears as a colorless liquid. " C 12512 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(C)(C)C Question about this molecule: What is the physical state of this molecule? Option A: It appears as a liquid. Option B: It appears as a colorless liquid. Option C: It is a liquid. Option D: It is a clear liquid. " C 31373 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=C(Cl)Cl)(Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It appears as a liquid. Option C: It is a liquid. Option D: It is a clear liquid. " C 6324 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC Question about this molecule: What is the physical state of this molecule? Option A: It is a clear liquid. Option B: It appears as a liquid. Option C: It is a liquid. Option D: It appears as a colorless liquid. " C 29740 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CBr)O Question about this molecule: What is the physical state of this molecule? Option A: It is a liquid. Option B: It appears as a liquid. Option C: It appears as a colorless liquid. Option D: It is a clear liquid. " A 4133 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)C1=CC=CC=C1O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It is a liquid. Option C: It appears as a liquid. Option D: It is a clear liquid. " B 7583 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)OC2=CC=CC=C2 Question about this molecule: What is the physical state of this molecule? Option A: It appears as a liquid. Option B: It is a clear liquid. Option C: It appears as a colorless liquid. Option D: It is a liquid. " D 757 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)O)O Question about this molecule: What is the physical state of this molecule? Option A: It is a solid. Option B: It is a crystalline solid. Option C: It is a colorless crystalline solid. Option D: It appears as a colorless crystalline solid. " A 11 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It appears as a liquid. Option B: It is a liquid. Option C: It is a clear liquid. Option D: It appears as a colorless liquid. " B 949 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C1=CC=CC=C1 Question about this molecule: What is the physical state of this molecule? Option A: It is a clear liquid. Option B: It is a liquid. Option C: It appears as a colorless liquid. Option D: It appears as a liquid. " B 1119 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=S=O Question about this molecule: What is the physical state of this molecule? Option A: It is a clear liquid. Option B: It appears as a colorless liquid. Option C: It is a liquid. Option D: It appears as a liquid. " C 8193 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCO Question about this molecule: What is the physical state of this molecule? Option A: It is a clear liquid. Option B: It appears as a liquid. Option C: It appears as a colorless liquid. Option D: It is a liquid. " D 2724247 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[As](=O)(C)[O-].[Na+] Question about this molecule: What is the physical state of this molecule? Option A: It is a solid. Option B: It is a colorless crystalline solid. Option C: It appears as a colorless crystalline solid. Option D: It is a crystalline solid. " A 5954 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC3=CC4=CC=CC=C4C=C32 Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless crystalline solid. Option B: It is a crystalline solid. Option C: It is a solid. Option D: It is a colorless crystalline solid. " C 7858 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCO Question about this molecule: What is the physical state of this molecule? Option A: It appears as a liquid. Option B: It is a clear liquid. Option C: It appears as a colorless liquid. Option D: It is a liquid. " D 311 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)O)C(CC(=O)O)(C(=O)O)O Question about this molecule: What is the physical state of this molecule? Option A: It is a crystalline solid. Option B: It is a solid. Option C: It is a colorless crystalline solid. Option D: It appears as a colorless crystalline solid. " B 1068 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CSC Question about this molecule: What is the physical state of this molecule? Option A: It is a liquid. Option B: It is a clear liquid. Option C: It appears as a colorless liquid. Option D: It appears as a liquid. " A 8113 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CO)NCCO Question about this molecule: What is the physical state of this molecule? Option A: It floats on water. Option B: Liquid or solid Option C: It sinks and mixes with water. Option D: Liquid floats and mixes with water. " B 7860 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)C=O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It is a liquid. Option C: It is a clear liquid. Option D: It appears as a liquid. " B 980 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1[N+](=O)[O-])O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless crystalline solid. Option B: It is a solid. Option C: It is a crystalline solid. Option D: It appears as a colorless crystalline solid. " B 8175 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCC=O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It appears as a liquid. Option C: It is a clear liquid. Option D: It is a liquid. " D 24570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: Cl[As](Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a clear liquid. Option B: It appears as a liquid. Option C: It is a liquid. Option D: It appears as a colorless liquid. " C 20393 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It is a liquid. Option B: It appears as a colorless liquid. Option C: It appears as a liquid. Option D: It is a clear liquid. " A 31405 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)C1=C(C(=CC=C1)C(C)(C)C)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless to pale yellow liquid. Option B: It is a clear, colorless to pale yellow liquid. Option C: Solid or liquid Option D: It appears as white to pale yellow paste or liquid. " C 5455 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C(=S)SSC(=S)N(C)C Question about this molecule: What is the physical state of this molecule? Option A: It appears as a liquid. Option B: It appears as a colorless liquid. Option C: It is a clear liquid. Option D: It is a liquid. " D 6558 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CN Question about this molecule: What is the physical state of this molecule? Option A: It appears as a liquid. Option B: It appears as a colorless liquid. Option C: It is a clear liquid. Option D: It is a liquid. " D 4944 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)OC1=CC=CC=C1OC(=O)NC Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless crystalline solid. Option B: It is a solid. Option C: It is a crystalline solid. Option D: It is a colorless crystalline solid. " B 1732 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CC(=C1)O)Cl Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless crystalline solid. Option B: It is a colorless crystalline solid. Option C: It is a solid. Option D: It is a crystalline solid. " C 126941 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It is a solid. Option B: It is a colorless crystalline solid. Option C: It appears as a colorless crystalline solid. Option D: It is a crystalline solid. " A 2244 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)OC1=CC=CC=C1C(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless crystalline solid. Option B: It appears as a colorless crystalline solid. Option C: It is a crystalline solid. Option D: It is a solid. " D 3634 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCNC1=C2C(=C(C=C1)CO)SC3=CC=CC=C3C2=O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless crystalline solid. Option B: It is a crystalline solid. Option C: It is a solid. Option D: It is a colorless crystalline solid. " C 2730 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OC1=NC(=C(C=C1Cl)Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid with a mild pleasant odor. Option B: It appears as a colorless liquid with a mild fruity odor. Option C: It is a white crystal-like solid with a strong odor. Option D: It appears as white solid with a flowery odor. " C 8456 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)C1=C(C=CC(=C1)OC)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a clear colorless liquid with a sweet fat-like odor. Option B: It is a clear yellow slightly viscous liquid with a pungent odor. Option C: It is a clear, slightly yellow liquid with a faint odor. Option D: It appears as white, beige or slightly yellow waxy solid with an aromatic odor and a slightly bitter burning taste. " D 2519 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C=NC2=C1C(=O)N(C(=O)N2C)C Question about this molecule: What is the physical state of this molecule? Option A: It appears as white, beige or slightly yellow waxy solid with an aromatic odor and a slightly bitter burning taste. Option B: It appears as white or reddish-yellow crystals or light brown powder. Option C: It appears as odorless white powder or white glistening needles, usually melted together. Option D: It appears as a white lustrous flaked solid with a fruity or spicy odor. " C 440917 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC[C@@H](CC1)C(=C)C Question about this molecule: What is the physical state of this molecule? Option A: It is a clear colorless oily liquid with a pleasant odor. Option B: It is a colorless liquid with a mild pleasant odor. Option C: It is a clear colorless mobile liquid with a pleasant lemon-like odor. Option D: It is a clear, colorless liquid with a pleasant odor. " C 527 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC=O Question about this molecule: What is the physical state of this molecule? Option A: It is a clear colorless liquid with an overpowering fruity-like odor. Option B: It appears as a clear colorless liquid with a strong chlorine-like odor. Option C: It appears as a clear colorless liquid with a sweet fat-like odor. Option D: It is a clear colorless mobile liquid with a pleasant lemon-like odor. " A 7302 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC(=O)OC1 Question about this molecule: What is the physical state of this molecule? Option A: It is a clear, colorless liquid with a pleasant odor. Option B: It is a colorless liquid with a mild pleasant odor. Option C: It is a clear colorless oily liquid with a pleasant odor. Option D: It is a colorless watery liquid with a pleasant odor. " C 12021 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)OC Question about this molecule: What is the physical state of this molecule? Option A: It is a clear, colorless liquid with a pleasant odor. Option B: It is a colorless liquid with a mild pleasant odor. Option C: It is a clear colorless oily liquid with a pleasant odor. Option D: It is a colorless watery liquid with a pleasant odor. " A 3102 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(=O)C2=CC=CC=C2 Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid with a mild pleasant odor. Option B: It appears as white solid with a flowery odor. Option C: It is a clear colorless oily liquid with a pleasant odor. Option D: It appears as a colorless liquid with a mild fruity odor. " B 2879 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid with a mild pleasant odor. Option B: It is a colorless solid with a tar like odor. Option C: It is a clear colorless oily liquid with a pleasant odor. Option D: It appears as a colorless liquid with a mild fruity odor. " B 5281744 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C=C\\1/CC(=C)[C@@](C(=O)OCC2=CCN3[C@H]2[C@@H](CC3)OC1=O)(CO)O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to white crystalline solid. Option B: It appears as a colorless to white crystalline solid. Option C: It is a colorless to off-white crystalline solid. Option D: It appears as a colorless to white lustrous solid. " C 638072 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC/C(=C/CC/C(=C/CC/C=C(/CC/C=C(/CCC=C(C)C)\\C)\\C)/C)/C)C Question about this molecule: What is the physical state of this molecule? Option A: It appears as a clear colorless liquid with a sweet fat-like odor. Option B: It appears as white, beige or slightly yellow waxy solid with an aromatic odor and a slightly bitter burning taste. Option C: It is a clear yellow slightly viscous liquid with a pungent odor. Option D: It is a clear, slightly yellow liquid with a faint odor. " D 445639 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCC/C=C\\CCCCCCCC(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It is a clear colorless oily liquid with a pleasant odor. Option B: It is a colorless liquid with a mild pleasant odor. Option C: It is a colorless watery liquid with a pleasant odor. Option D: It is a colorless to pale yellow liquid with a mild odor. " D 7463 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)C(C)C Question about this molecule: What is the physical state of this molecule? Option A: It is a clear colorless oily liquid with a pleasant odor. Option B: It appears as a colorless liquid with a mild fruity odor. Option C: It is a colorless liquid with a mild pleasant odor. Option D: It is a clear, colorless liquid with a pleasant odor. " C 25670 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)SCSC(C)(C)C Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to pale yellow crystalline solid. Option B: It appears as a colorless to pale yellow liquid. Option C: It is a clear, colorless to pale yellow liquid. Option D: It occurs as a colorless to pale yellow solid. " C 11192 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)[O-].CC(=O)[O-].[Zn+2] Question about this molecule: What is the physical state of this molecule? Option A: Both the hydrate and the anhydrous forms are colorless solids. Option B: It is a colorless crystalline solid. Option C: It is an odorless and colorless solid. Option D: It is a solution of a colorless crystalline solid. " A 19395 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OP(=S)(OCC)OCC Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to pale yellow mobile oil. Option B: It is a colorless to pale yellow oily liquid. Option C: It occurs as a colorless to pale yellow solid. Option D: It appears as a colorless to pale yellow liquid. " A 24588 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Be+2].[Cl-].[Cl-] Question about this molecule: What is the physical state of this molecule? Option A: It is a white to tan solid. Option B: It is a white to yellow solid. Option C: It is a white to green solid. Option D: It is a colorless to yellow crystalline solid. " C 7434 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C=C1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: What is the physical state of this molecule? Option A: It is a dense colorless liquid. Option B: It appears as a clear colorless liquid. Option C: It is a clear colorless liquid. Option D: It is a high explosive when dry. " D 31236 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)OCCO Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless, fuming oily liquid. Option B: It appears as a colorless oily liquid. Option C: It is a colorless, clear, oily liquid. Option D: It appears as a colorless, oily liquid. " C 8146 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOCCOCCO Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to slightly yellow viscous liquid. Option B: It is a slightly yellow viscous liquid. Option C: It is a colorless to yellow slightly viscous liquid. Option D: It appears as a colorless, slightly viscous liquid. " D 6720 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=C(C(=C(C(=C1Cl)Cl)Cl)Cl)Cl)[N+](=O)[O-] Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless to light yellow or brown liquid. Option B: It appears as crystalline pale yellow to white solid or powder. Option C: It appears as a colorless to pale yellow liquid. Option D: It appears as a yellow to red solid or heated liquid. " B 948 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N-]=[N+]=O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless, sweet-tasting gas. Option B: It is a colorless, odorless gas. Option C: It is a colorless, sweet-smelling liquid. Option D: It is a colorless, clear, oily liquid. " A 4 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CN)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It is a colorless liquid. Option C: It is a dense colorless liquid. Option D: It is a clear colorless liquid. " A 7239 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It appears as a clear colorless liquid. Option B: It is a clear colorless liquid. Option C: It is a dense colorless liquid. Option D: It is a non-polar colorless liquid. " D 13190 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCC=C Question about this molecule: What is the physical state of this molecule? Option A: It floats on water. Option B: It appears as a colorless liquid. Option C: It is a colorless liquid. Option D: It sinks and mixes with water. " A 6279 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1C[C@@H]2[C@H](CC[C@]3([C@H]2CC[C@@]3(C(=O)C)OC(=O)C)C)[C@@]4(C1=CC(=O)CC4)C Question about this molecule: What is the physical state of this molecule? Option A: It is an odorless white to slightly yellow crystalline powder. Option B: It is an odorless white to light-yellow crystalline powder. Option C: It is an odorless white to off-white crystalline powder. Option D: It is an odorless white to off-white microcrystalline powder. " D 6574 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless, fuming oily liquid. Option B: It is a colorless, sweet-smelling liquid. Option C: It is a colorless, clear, oily liquid. Option D: It appears as a colorless, oily liquid. " B 4771 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(CC1=CC=CC=C1)N Question about this molecule: What is the physical state of this molecule? Option A: It is an oily yellow liquid. Option B: It is an oily liquid. Option C: It is a colorless oily liquid. Option D: It appears as an oily straw yellow clear liquid. " B 54670067 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O Question about this molecule: What is the physical state of this molecule? Option A: It is an odorless white to light-yellow crystalline powder. Option B: It is an odorless white to off-white crystalline powder. Option C: It is a white to very pale yellow crystalline powder. Option D: It is an odorless white to slightly yellow crystalline powder. " C 887 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CO Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless, flammable liquid. Option B: It is a light, volatile, colourless, flammable, poisonous liquid. Option C: It is a colorless, mobile, flammable liquid. Option D: It is a low-boiling colorless, flammable liquid. " B 241 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=CC=C1 Question about this molecule: What is the physical state of this molecule? Option A: It appears as a clear colorless liquid. Option B: It is a dense colorless liquid. Option C: It is a clear colorless liquid. Option D: It appears as a colorless liquid. " A 5281 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCCCCCCC(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It sinks and mixes with water. Option B: It appears as a colorless liquid. Option C: It is a colorless liquid. Option D: It floats on water. " D 8209 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCCCO Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to straw-colored liquid. Option B: It is a colorless thick liquid (heated). Option C: It is a colorless to straw colored liquid. Option D: It appears as a clear colorless liquid. " B 7954 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=NC(=NC(=N1)Cl)Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a solution of a colorless crystalline solid. Option B: It is a colorless to yellow crystalline solid. Option C: It appears as a colorless crystalline solid. Option D: It is a colorless crystalline solid. " C 15415 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)CC(C(=O)OCC)SP(=O)(OC)OC Question about this molecule: What is the physical state of this molecule? Option A: It is a viscous liquid at room temperature. Option B: It is a clear colorless viscous liquid. Option C: It is a colorless viscous oily liquid. Option D: It is a viscous oily liquid. " C 3118 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)SCCSCC Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless, oily liquid. Option B: It is a colorless, clear, oily liquid. Option C: It is a dark, yellow, oily liquid. Option D: It appears as a colorless, fuming oily liquid. " C 62329 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=C(C(=C1[N+](=O)[O-])C(C)(C)C)[N+](=O)[O-])C)[N+](=O)[O-] Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless to white lustrous solid. Option B: It is a white to light-colored crystalline solid. Option C: It is a colorless to white crystalline solid. Option D: It appears as a colorless to white crystalline solid. " B 445354 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/CO)/C)/C Question about this molecule: What is the physical state of this molecule? Option A: It appears as colorless crystals or light brown powder. Option B: It appears as brown waxy solid or colorless solid. Option C: It appears as colorless crystals or white powder or chunky white solid. Option D: It appears as yellow crystals or orange solid. " D 6354 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CO1 Question about this molecule: What is the physical state of this molecule? Option A: It is a water-white mobile liquid. Option B: It is a colorless watery liquid. Option C: It appears as a water-white liquid. Option D: It is a liquid less dense than water. " D 23938 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Pd] Question about this molecule: What is the physical state of this molecule? Option A: It is a silvery-white liquid. Option B: It is a hard, silvery-white metal. Option C: It is a rare and lustrous silvery-white metal. Option D: It is a colorless to pale yellow oily liquid. " C 7948 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC(=C1)O)C Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless to white crystalline solid. Option B: It appears as a colorless to white lustrous solid. Option C: It is a colorless to off-white crystalline solid. Option D: It is a colorless to white crystalline solid. " C 3030 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C=CC(=C1C(=O)O)Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It appears as a liquid. Option C: It is a liquid. Option D: It is a clear liquid. " C 7047 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC=N2 Question about this molecule: What is the physical state of this molecule? Option A: It is a colourless hygroscopic liquid. Option B: It is a solution of a colorless crystalline solid. Option C: It is a colorless crystalline solid. Option D: It appears as a colorless crystalline solid. " A 9076 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC1=CC=C(C=C1)N Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to light yellow liquid. Option B: It appears as a colorless to light yellow liquid. Option C: It is a colorless to dark red liquid. Option D: It appears as a dark brown liquid. " C 11430 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)([O-])[O-].[K+].[K+] Question about this molecule: What is the physical state of this molecule? Option A: It is a white crystalline solid. Option B: It is a white crystalline powder. Option C: It is a white salt. Option D: It is a white powder. " C 8263 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(C(C(C1(F)F)(F)F)(F)F)(F)F Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless flammable gas. Option B: It is a colorless nonflammable gas. Option C: It is a colorless flammable highly toxic gas. Option D: It is a colorless flammable gas which is heavier than air. " B 7847 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC=O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless volatile liquid. Option B: It appears as a colorless volatile liquid. Option C: It is a clear colorless highly volatile liquid. Option D: It appears as a colorless to yellow volatile liquid. " D 5853 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=O)(C(C(Cl)(Cl)Cl)O)OC Question about this molecule: What is the physical state of this molecule? Option A: It is a wettable powder. Option B: It appears as a white crystalline, odorless powder. Option C: It is a white crystalline powder. Option D: It is a white crystalline, wettable powder. " A 2723790 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=S)(N)N Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It floats on water. Option C: It sinks and mixes with water. Option D: It is a colorless liquid. " C 7362 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=COC(=C1)C=O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless or slightly yellow oily liquid. Option B: It appears as colorless or reddish-brown mobile liquids. Option C: It appears as clear colorless or faintly yellow slightly viscous liquid. Option D: It appears as colorless or slightly yellow watery liquid. " B 637090 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C=C/C(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a crystalline solid or a liquid with a sharp odor. Option B: It is shipped as a solid or liquid solution. Option C: It is shipped as either a solid or liquid. Option D: It is a low melting solid or viscous liquid. " C 5569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN(CCC)C1=C(C=C(C=C1[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-] Question about this molecule: What is the physical state of this molecule? Option A: It is a yellow-orange crystalline solid. Option B: It appears as a yellowish white crystalline solid. Option C: It is a yellow-green crystalline solid. Option D: It is a yellowish-colored crystalline solid. " A 7854 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC#N Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid. Option B: It appears as a colorless liquid. Option C: It is a clear colorless liquid. Option D: It is a dense colorless liquid. " B 7849 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CBr)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a dense colorless liquid. Option B: It appears as a clear colorless liquid. Option C: It is a clear colorless liquid. Option D: It appears as a colorless liquid. " C 24644 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O.O.O.O.O.O.[Mg+2].[Cl-].[Cl-] Question about this molecule: What is the physical state of this molecule? Option A: It is a mineral. Option B: It is a crystalline solid. Option C: It is a solid. Option D: It appears as a colorless crystalline solid. " A 26623 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Hg+2] Question about this molecule: What is the physical state of this molecule? Option A: It is a clear colorless liquid. Option B: It is a liquid at room temperature. Option C: It appears as a clear colorless liquid. Option D: It is a colorless liquid at room temperature. " B 977 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid. Option B: It is a colorless gas. Option C: It appears as a colorless liquid. Option D: It is a gas. " B 13381 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCC=C Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless oily liquid. Option B: It is a colorless oily liquid. Option C: It appears as a colorless, oily liquid. Option D: It is a colorless watery liquid. " D 6093260 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O.O.[Cl-].[Cl-].[Ca+2] Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless crystalline solid. Option B: It is a mineral. Option C: It is a solid. Option D: It is a crystalline solid. " B 3562 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(F)(F)F)(Cl)Br Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless volatile liquid. Option B: It is a clear colorless highly volatile liquid. Option C: It is a colorless and highly volatile liquid. Option D: It appears as a colorless volatile liquid. " B 712 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless flammable gas. Option B: It is a colorless flammable gas which is heavier than air. Option C: It is a colorless flammable highly toxic gas. Option D: It is a colorless nonflammable gas. " A 23969 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [AsH3] Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless flammable gas which is heavier than air. Option B: It is a colorless flammable gas. Option C: It is a colorless flammable highly toxic gas. Option D: It is a colorless nonflammable gas. " C 3032297 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CNC(=S)[S-])NC(=S)[S-].[Na+].[Na+] Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to light amber solid. Option B: It is a clear colorless to light amber liquid. Option C: It is a colorless to light yellow liquid. Option D: It is a clear colorless to light yellow liquid. " A 23925 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Fe] Question about this molecule: What is the physical state of this molecule? Option A: It is a solid. Option B: It appears as a colorless crystalline solid. Option C: It is a crystalline solid. Option D: It is a mineral. " D 7577 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CC2=CC=C(C=C2)N)N Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless to pale yellow liquid. Option B: It occurs as a colorless to pale yellow solid. Option C: It is a colorless to pale yellow crystalline solid. Option D: It is a colorless to yellow crystalline solid. " B 6360 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless gas. Option B: It is a gas. Option C: It appears as a colorless liquid. Option D: It is a colorless liquid. " A 31253 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCCC(=C)C=C)C Question about this molecule: What is the physical state of this molecule? Option A: It appears as a yellow oily liquid. Option B: It is a colorless to pale yellow oily liquid. Option C: It is a colorless or slightly yellow oily liquid. Option D: It is a pale yellow oily liquid. " A 784 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OO Question about this molecule: What is the physical state of this molecule? Option A: It appears as a clear colorless liquid. Option B: It is a clear colorless liquid. Option C: It is a colorless liquid at room temperature. Option D: It is a liquid at room temperature. " C 7504 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)CN Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to light yellow liquid. Option B: It appears as a colorless to pale yellow liquid. Option C: It is a clear colorless to light yellow liquid. Option D: It appears as a colorless to light yellow liquid. " A 7895 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(=O)C Question about this molecule: What is the physical state of this molecule? Option A: It sinks and mixes with water. Option B: It is a colorless liquid. Option C: It floats on water. Option D: It appears as a colorless liquid. " C 23665760 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]Cl.[Na+] Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to pale yellow oily liquid. Option B: It appears as colorless or slightly yellow watery liquid. Option C: It is a colourless or pale yellow oily liquid. Option D: It is a colorless or slightly yellow oily liquid. " B 9253 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCCC1 Question about this molecule: What is the physical state of this molecule? Option A: It is a clear colorless liquid. Option B: It is a dense colorless liquid. Option C: It appears as a clear colorless liquid. Option D: It appears as a colorless liquid. " C 39793 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=O)(C)SCCN(C(C)C)C(C)C Question about this molecule: What is the physical state of this molecule? Option A: It is an odorless liquid. Option B: It appears as a colorless liquid. Option C: It is a dense colorless liquid. Option D: It is a colorless liquid. " A 14778 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=[Ca] Question about this molecule: What is the physical state of this molecule? Option A: It appears as an odorless white or gray-white solid. Option B: It is an odorless white to off-white microcrystalline powder. Option C: It is an odorless white to off-white crystalline powder. Option D: It is an odorless white to slightly yellow crystalline powder. " A 24823 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-][O+]=O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless nonflammable gas. Option B: It is a colorless flammable highly toxic gas. Option C: It is a colorless flammable gas. Option D: It appears as a colorless to bluish gas. " D 13539 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(COC(=O)C(=C)C)O Question about this molecule: What is the physical state of this molecule? Option A: It is a white liquid. Option B: It appears as a colorless liquid. Option C: It is a colorless liquid. Option D: It appears as a white liquid. " D 6344 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a clear colorless liquid. Option B: It appears as a colorless liquid. Option C: It is a dense colorless liquid. Option D: It is a colorless liquid. " D 10469 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It is a white crystalline powder. Option B: It is a white crystalline powder or solid. Option C: It is a fine white crystalline solid. Option D: It is a white crystalline solid. " D 7965 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(CC1)N Question about this molecule: What is the physical state of this molecule? Option A: It appears as a clear colorless to yellow liquid. Option B: It is a clear colorless to light yellow liquid. Option C: It appears as a colorless to light yellow liquid. Option D: It is a colorless to light yellow liquid. " A 4624 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=CC(=C1O)O)O)CCN Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless crystalline solid. Option B: It is a solid. Option C: It is a crystalline solid. Option D: It appears as a colorless crystalline solid. " B 5144 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCC1=CC2=C(C=C1)OCO2 Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to pale yellow oily liquid. Option B: It is a colorless or slightly yellow oily liquid. Option C: It is a colourless or pale yellow oily liquid. Option D: It appears as colorless or slightly yellow watery liquid. " B 177 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC=O Question about this molecule: What is the physical state of this molecule? Option A: It is a dense colorless liquid. Option B: It appears as a clear colorless liquid. Option C: It appears as a colorless liquid. Option D: It is a clear colorless liquid. " B 7843 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid. Option B: It is a colorless gas. Option C: It appears as a colorless liquid. Option D: It is a gas. " B 8561 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCC Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to light yellow liquid. Option B: It appears as a colorless to pale yellow liquid. Option C: It appears as a colorless to light yellow liquid. Option D: It is a clear colorless to light yellow liquid. " D 3226 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(OC(F)F)(F)F)(F)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless, mobile, flammable liquid. Option B: It is a light, volatile, colourless, flammable, poisonous liquid. Option C: It is a colorless, flammable liquid. Option D: It exists as a clear, colorless, odorless to sweet, volatile liquid. " D 7618 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CO)N(CCO)CCO Question about this molecule: What is the physical state of this molecule? Option A: It is an oily yellow liquid. Option B: It appears as an oily straw yellow clear liquid. Option C: It is a colorless oily liquid. Option D: It is an oily liquid. " D 4284 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)C(=O)C1=CC=CC(=C1)C Question about this molecule: What is the physical state of this molecule? Option A: It appears as colorless or slightly yellow watery liquid. Option B: It appears as clear colorless or faintly yellow slightly viscous liquid. Option C: It is a colourless or pale yellow oily liquid. Option D: It is a colorless or slightly yellow oily liquid. " B 340 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=CC=C1)O)O Question about this molecule: What is the physical state of this molecule? Option A: It is a solid. Option B: It is a crystalline solid. Option C: It appears as a colorless crystalline solid. Option D: It is a colorless crystalline solid. " A 8846 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOC(=O)C=C Question about this molecule: What is the physical state of this molecule? Option A: It is a dense colorless liquid. Option B: It appears as a clear colorless liquid. Option C: It appears as a colorless liquid. Option D: It is a clear colorless liquid. " B 6386 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless, oily liquid. Option B: It appears as a colorless oily liquid. Option C: It appears as a colorless, fuming oily liquid. Option D: It is a colorless oily liquid. " D 3016 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3 Question about this molecule: What is the physical state of this molecule? Option A: It is an odorless white to off-white microcrystalline powder. Option B: It is an odorless white to slightly yellow crystalline powder. Option C: It is an off-white to yellow crystalline powder. Option D: It is an odorless white to off-white crystalline powder. " C 40326 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C(C1C(=O)OCC2=CC(=CC=C2)OC3=CC=CC=C3)C=C(Cl)Cl)C Question about this molecule: What is the physical state of this molecule? Option A: It is a viscous oily liquid. Option B: It is a clear colorless viscous liquid. Option C: It is a colorless viscous oily liquid. Option D: It is a low melting solid or viscous liquid. " D 24489 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]S(=O)S(=O)[O-].[Na+].[Na+] Question about this molecule: What is the physical state of this molecule? Option A: It appears as a yellowish white crystalline solid. Option B: It is a whitish to light yellow crystalline solid. Option C: It is a colorless to pale yellow crystalline solid. Option D: It is a yellowish-colored crystalline solid. " B 8179 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOCCOCCOCC Question about this molecule: What is the physical state of this molecule? Option A: It is a viscous oily liquid. Option B: It is a colorless viscous oily liquid. Option C: It is a clear colorless viscous liquid. Option D: It is a viscous liquid at room temperature. " C 428 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CN)CN Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless watery liquid. Option B: It appears as a water-white liquid. Option C: It is a colorless oily liquid. Option D: It is a water-white mobile liquid. " D 6811 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=O)OC2=O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless to white crystalline solid. Option B: It is a colorless to pale yellow crystalline solid. Option C: It appears as a colorless to white lustrous solid. Option D: It is a colorless to white crystalline solid. " C 9555 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(C(C(C(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a liquid. Option B: It is a clear liquid. Option C: It is a liquid. Option D: It appears as a colorless liquid. " C 5360835 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Ga] Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless oily liquid. Option B: It is a colorless oily liquid. Option C: It is a silvery-white liquid. Option D: It appears as a colorless, oily liquid. " C 3423265 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCOS(=O)(=O)[O-].[Na+] Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to pale yellow oily liquid. Option B: It is a clear, colorless to pale yellow liquid. Option C: It appears as white to pale yellow paste or liquid. Option D: It appears as a colorless to pale yellow liquid. " C 11552 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CC=O Question about this molecule: What is the physical state of this molecule? Option A: It is a dense colorless liquid. Option B: It is a clear colorless liquid. Option C: It is a colorless liquid. Option D: It appears as a colorless liquid. " C 5971 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCN=C=S Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless to pale-yellow oily liquid. Option B: It is a clear, colorless, slightly syrupy liquid at room temperature. Option C: It is a colorless, clear, oily liquid. Option D: It is a clear, colorless to light-yellow liquid. " A 23668193 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: N(=O)[O-].[Na+] Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to yellow crystalline solid. Option B: It is a colorless to pale yellow crystalline solid. Option C: It appears as a yellowish white crystalline solid. Option D: It is a yellowish-colored crystalline solid. " C 60962 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)NN.Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a white to yellow solid. Option B: It is a colorless to yellow crystalline solid. Option C: It is a white to tan solid. Option D: It is a white to green solid. " C 7964 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a light, volatile, colourless, flammable, poisonous liquid. Option B: It is a colorless, flammable liquid. Option C: It is a colorless, mobile, flammable liquid. Option D: It is a low-boiling colorless, flammable liquid. " B 8071 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCOC Question about this molecule: What is the physical state of this molecule? Option A: It is a clear liquid. Option B: It is a liquid. Option C: It appears as a liquid. Option D: It appears as a colorless liquid. " C 444795 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C(=O)O)/C)/C Question about this molecule: What is the physical state of this molecule? Option A: It is a yellow-green crystalline solid. Option B: It is a yellow to light-orange crystalline powder. Option C: It is a yellow-orange crystalline solid. Option D: It is a yellowish-colored crystalline solid. " B 444266 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=C\\C(=O)O)\\C(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to yellow crystalline solid. Option B: It is a colorless crystalline solid. Option C: It is a solution of a colorless crystalline solid. Option D: It appears as a colorless crystalline solid. " B 996 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)O Question about this molecule: What is the physical state of this molecule? Option A: It is a crystalline solid. Option B: It appears as a colorless crystalline solid. Option C: It is a solid. Option D: It is a colorless crystalline solid. " C 6654 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CCC2CC1C2(C)C Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It is a liquid. Option C: It appears as a liquid. Option D: It is a clear liquid. " B 8881 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCl)CCl Question about this molecule: What is the physical state of this molecule? Option A: It is a clear liquid. Option B: It appears as a colorless liquid. Option C: It appears as a liquid. Option D: It is a liquid. " D 8082 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCNCC1 Question about this molecule: What is the physical state of this molecule? Option A: It is a clear liquid. Option B: It is a liquid. Option C: It appears as a colorless liquid. Option D: It appears as a liquid. " B 13836 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+](C)(C)CCCl.[Cl-] Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless crystalline solid. Option B: It is a crystalline solid. Option C: It is a solid. Option D: It appears as a colorless crystalline solid. " C 2788 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC2=C(C(=C(C=C2Cl)I)O)N=C1 Question about this molecule: What is the physical state of this molecule? Option A: It is a solid. Option B: It is a crystalline solid. Option C: It appears as a colorless crystalline solid. Option D: It is a colorless crystalline solid. " A 9223 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CO2 Question about this molecule: What is the physical state of this molecule? Option A: It is a liquid. Option B: It appears as a colorless liquid. Option C: It appears as a liquid. Option D: It is a clear liquid. " A 7298 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(C1)O Question about this molecule: What is the physical state of this molecule? Option A: It is a clear liquid. Option B: It is a liquid. Option C: It appears as a liquid. Option D: It appears as a colorless liquid. " B 6953 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1[N+](=O)[O-])Cl)[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless crystalline solid. Option B: It is a crystalline solid. Option C: It appears as a colorless crystalline solid. Option D: It is a solid. " D 6591 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)Cl)(Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It is a liquid. Option C: It appears as a liquid. Option D: It is a clear liquid. " B 8184 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCO Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It appears as a liquid. Option C: It is a clear liquid. Option D: It is a liquid. " D 8133 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOCCO Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It appears as a liquid. Option C: It is a clear liquid. Option D: It is a liquid. " D 7921 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1CCC(=O)O1 Question about this molecule: What is the physical state of this molecule? Option A: It is a clear liquid. Option B: It appears as a colorless liquid. Option C: It appears as a liquid. Option D: It is a liquid. " D 9086 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CN)CO Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It appears as a liquid. Option C: It is a liquid. Option D: It is a clear liquid. " C 15450 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CCCCCO Question about this molecule: What is the physical state of this molecule? Option A: It is a clear liquid. Option B: It appears as a liquid. Option C: It is a liquid. Option D: It appears as a colorless liquid. " C 3314 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C=CC(=C1)CC=C)O Question about this molecule: What is the physical state of this molecule? Option A: It is a clear liquid. Option B: It appears as a liquid. Option C: It appears as a colorless liquid. Option D: It is a liquid. " D 1030 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CO)O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid with a mild pleasant odor. Option B: It is a clear colorless oily liquid with a pleasant odor. Option C: It is a clear, colorless, slightly syrupy liquid at room temperature. Option D: It is a clear, colorless liquid with a pleasant odor. " C 180 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C Question about this molecule: What is the physical state of this molecule? Option A: It is a light, volatile, colourless, flammable, poisonous liquid. Option B: It is a colorless, mobile, flammable liquid. Option C: It is a colorless, flammable liquid. Option D: It is a low-boiling colorless, flammable liquid. " B 8268 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C(C2=CC=C(C=C2)Cl)(C(Cl)(Cl)Cl)O)Cl Question about this molecule: What is the physical state of this molecule? Option A: It appears as a white crystalline, odorless powder. Option B: It is an odorless white to slightly yellow crystalline powder. Option C: It is an odorless white to light-yellow crystalline powder. Option D: It is a white crystalline, wettable powder. " D 7288 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)CC Question about this molecule: What is the physical state of this molecule? Option A: It is a dense colorless liquid. Option B: It is a clear colorless liquid. Option C: It appears as a colorless liquid. Option D: It appears as a clear colorless liquid. " D 16078 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC1=CC(=C2[C@@H]3C=C(CC[C@H]3C(OC2=C1)(C)C)C)O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless, crystalline solid with a camphor-like odor. Option B: It appears as a brown amorphous semi-solid, viscous oil or chunky golden yellow solid. Option C: It appears as a slightly oily colorless to yellow liquid with a strong irritating odor. Option D: At room temperature and pressure, ortho- and meta-toluidines are viscous liquids, but para-toluidine is a flaky solid. " B 8130 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCC=O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless, oily liquid. Option B: It appears as a colorless, fuming oily liquid. Option C: It appears as a colorless oily liquid. Option D: It is a colorless oily liquid. " A 8141 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCC Question about this molecule: What is the physical state of this molecule? Option A: It appears as a clear colorless liquid. Option B: It appears as a colorless liquid. Option C: It is a dense colorless liquid. Option D: It is a clear colorless liquid. " A 22985 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [NH4+].[N+](=O)([O-])[O-] Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless crystalline solid. Option B: It is a colorless to yellow crystalline solid. Option C: It is a solution of a colorless crystalline solid. Option D: It appears as a colorless crystalline solid. " A 1140 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1 Question about this molecule: What is the physical state of this molecule? Option A: It appears as a clear colorless liquid. Option B: It is a clear colorless liquid. Option C: It is a dense colorless liquid. Option D: It is a clear, colorless liquid. " D 612 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C(=O)O)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless to yellow syrupy liquid. Option B: It appears as a colorless to pale yellow liquid. Option C: It appears as a colorless to light yellow liquid. Option D: It is a colorless to pale yellow oily liquid. " A 6093252 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O.O.O.O.O.O.[Cl-].[Cl-].[Ca+2] Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless crystalline solid. Option B: It is a solid. Option C: It is a crystalline solid. Option D: It appears as a colorless crystalline solid. " B 6561 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C=O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It sinks and mixes with water. Option C: It is a colorless liquid. Option D: It floats on water. " D 13344 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[K+].[K+].[K+] Question about this molecule: What is the physical state of this molecule? Option A: It is a white crystalline powder. Option B: It is a white powder. Option C: It is a crystalline powder. Option D: It is a powder. " A 992 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=C(C(=C(C(=C1Cl)Cl)Cl)Cl)Cl)O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to light yellow liquid. Option B: It appears as a dark brown liquid. Option C: It is a dark gray to brown solid. Option D: It is a colorless to dark red liquid. " C 2578 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCl)NC(=O)N(CCCl)N=O Question about this molecule: What is the physical state of this molecule? Option A: It is an oily liquid. Option B: It is an orange-yellow solid. Option C: It appears as an oily straw yellow clear liquid. Option D: It is an oily yellow liquid. " B 935 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Ni] Question about this molecule: What is the physical state of this molecule? Option A: It is a silvery-white liquid. Option B: It is a hard, silvery-white metal. Option C: It is a colorless to pale yellow oily liquid. Option D: It is a rare and lustrous silvery-white metal. " B 9740 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C#N)C(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It sinks and mixes with water. Option B: It appears as a colorless liquid. Option C: It floats on water. Option D: It is a colorless liquid. " A 5801 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)N)O Question about this molecule: What is the physical state of this molecule? Option A: It is either a white or reddish colored crystals, or a solution of the crystals and a solvent. Option B: It appears as white or reddish-yellow crystals or light brown powder. Option C: It appears as colorless crystals or granules or light gray powder. Option D: It appears as colorless to white monoclinic crystals or prisms or white powder. " A 24393 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]S(=O)(=O)[O-].[Fe+2] Question about this molecule: What is the physical state of this molecule? Option A: It is a white to off-white or faintly yellow crystalline powder. Option B: It is an odorless white to slightly yellow crystalline powder. Option C: It is a white to very pale yellow crystalline powder. Option D: It appears as a greenish or yellow-brown crystalline solid. " D 31285 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCC=C Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid with a mild pleasant odor. Option B: It is a colorless liquid with an odor of gasoline. Option C: It appears as a colorless liquid with a mild fruity odor. Option D: It is a clear, colorless liquid with a pleasant odor. " B 7242 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1N Question about this molecule: What is the physical state of this molecule? Option A: It appears as a slightly oily colorless to yellow liquid with a strong irritating odor. Option B: It appears as a brown amorphous semi-solid, viscous oil or chunky golden yellow solid. Option C: At room temperature and pressure, ortho- and meta-toluidines are viscous liquids, but para-toluidine is a flaky solid. Option D: It is a colorless, crystalline solid with a camphor-like odor. " C 8376 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to yellow crystalline solid. Option B: It occurs as a colorless to pale yellow solid. Option C: It is a colorless to pale yellow crystalline solid. Option D: It is a yellow, odorless solid. " D 3283 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOCC Question about this molecule: What is the physical state of this molecule? Option A: It appears as a clear colorless liquid with a sweet fat-like odor. Option B: It is a clear colorless liquid with an overpowering fruity-like odor. Option C: It appears as a clear colorless liquid with an anesthetic odor. Option D: It appears as a clear colorless liquid with a strong chlorine-like odor. " C 8892 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It is a clear colorless to amber liquid with a sweet aromatic odor. Option B: It is a clear colorless oily liquid with a pleasant odor. Option C: It appears as a white crystalline solid or colorless to light yellow solution with an unpleasant odor. Option D: It appears as a clear colorless to yellow liquid with a bitter almond odor. " C 234 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O[As](=O)(O)O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless crystalline solid. Option B: It appears as a clear colorless aqueous solution. Option C: It is a solution of a colorless crystalline solid. Option D: It appears as a colorless crystalline solid. " B 8691 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)N=NC2=C(N=C(C=C2)N)N.Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a clear, slightly yellow liquid with a faint odor. Option B: It is a clear yellow slightly viscous liquid with a pungent odor. Option C: It appears as white, beige or slightly yellow waxy solid with an aromatic odor and a slightly bitter burning taste. Option D: Aqueous solutions are yellow to brick-red and slightly acidic; they may be stabilized by the addition of 10% glucose. " D 6564 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CCl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless, flammable liquid with a chloroform-like odor. Option B: It is a colorless, crystalline solid with a camphor-like odor. Option C: It appears as a clear colorless liquid with a sweet fat-like odor. Option D: It appears as a clear colorless liquid with a geranium-like odor. " A 24586 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]S(=O)(=O)[O-].[Ni+2] Question about this molecule: What is the physical state of this molecule? Option A: It is a yellowish-colored crystalline solid. Option B: It appears as a yellowish white crystalline solid. Option C: It is a yellow-orange crystalline solid. Option D: It is a yellow-green crystalline solid. " D 164825 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1N=NC2C(=NN(C2=O)C3=CC=C(C=C3)S(=O)(=O)[O-])C(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+] Question about this molecule: What is the physical state of this molecule? Option A: It is an odorless white to off-white crystalline powder. Option B: It is a yellow to greenish-yellow powder. Option C: It is an odorless white to slightly yellow crystalline powder. Option D: It is an odorless white to light-yellow crystalline powder. " B 6214 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)(Cl)Cl)(Cl)(Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless, flammable liquid with a chloroform-like odor. Option B: It is a colorless, crystalline solid with a camphor-like odor. Option C: It appears as a clear colorless liquid with a geranium-like odor. Option D: It appears as a clear colorless liquid with a sweet fat-like odor. " B 5756 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1C[C@H]([C@@H]2O)O)CCC4=C3C=CC(=C4)O Question about this molecule: What is the physical state of this molecule? Option A: It is a crystalline solid. Option B: It appears as a colorless crystalline solid. Option C: It is a solid. Option D: It is a colorless crystalline solid. " C 4169 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC1=CC=CC(=C1N(C(C)COC)C(=O)CCl)C Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It is a liquid. Option C: It is a clear liquid. Option D: It appears as a liquid. " B 6337 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCl Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless gas. Option B: It is a gas. Option C: It appears as a colorless liquid. Option D: It is a colorless liquid. " B 5327 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=NC(=N1)NS(=O)(=O)C2=CC=C(C=C2)N)C Question about this molecule: What is the physical state of this molecule? Option A: It is a white crystalline powder. Option B: It is a crystalline powder. Option C: It is a powder. Option D: It is a white powder. " C 1100 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OS(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It is a clear liquid. Option B: It appears as a colorless liquid. Option C: It appears as a liquid. Option D: It is a liquid. " D 6209 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+](C)(C)CCO.[Cl-] Question about this molecule: What is the physical state of this molecule? Option A: It is a dense colorless liquid. Option B: It appears as a colorless liquid. Option C: It is a solution. Option D: It is a colorless liquid. " C 7515 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC1=CC=CC=C1 Question about this molecule: What is the physical state of this molecule? Option A: It is a clear liquid. Option B: It appears as a colorless liquid. Option C: It is a liquid. Option D: It appears as a liquid. " C 8003 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC Question about this molecule: What is the physical state of this molecule? Option A: It is a liquid. Option B: It appears as a colorless liquid. Option C: It is a clear liquid. Option D: It appears as a liquid. " A 165339 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@@H](C(=O)O)N)SO Question about this molecule: What is the physical state of this molecule? Option A: It is a crystalline solid. Option B: It is a solid. Option C: It appears as a colorless crystalline solid. Option D: It is a colorless crystalline solid. " B 8019 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCO Question about this molecule: What is the physical state of this molecule? Option A: It is a clear liquid. Option B: It is a liquid. Option C: It appears as a colorless liquid. Option D: It appears as a liquid. " B 23976 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Cr] Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless crystalline solid. Option B: It is a solid. Option C: It appears as a colorless crystalline solid. Option D: It is a crystalline solid. " B 18502 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(CC1)N=C=O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a liquid. Option B: It appears as a colorless liquid. Option C: It is a clear liquid. Option D: It is a liquid. " D 5282379 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C\\C(=O)O)/C)/C Question about this molecule: What is the physical state of this molecule? Option A: It is a white crystalline powder. Option B: It is a white powder. Option C: It is a crystalline powder. Option D: It is a powder. " D 3286 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)SCSP(=S)(OCC)OCC Question about this molecule: What is the physical state of this molecule? Option A: It is a liquid. Option B: It appears as a liquid. Option C: It is a clear liquid. Option D: It appears as a colorless liquid. " A 23670523 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1N)[As](=O)(O)[O-].[Na+] Question about this molecule: What is the physical state of this molecule? Option A: It is a white crystalline, wettable powder. Option B: It appears as a white crystalline, odorless powder. Option C: It is an odorless white to light-yellow crystalline powder. Option D: It is an odorless white to slightly yellow crystalline powder. " B 457928 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)OC(=O)CC(C)(C)C(=O)O)C)C(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless crystalline solid. Option B: It is a crystalline solid. Option C: It is a solid. Option D: It is a colorless crystalline solid. " C 6422 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(F)(F)F)O Question about this molecule: What is the physical state of this molecule? Option A: It is a clear yellow slightly viscous liquid with a pungent odor. Option B: It appears as a clear colorless liquid with a geranium-like odor. Option C: It appears as a clear colorless liquid with a sweet fat-like odor. Option D: It appears as a colorless fuming liquid with a pungent odor. " D 6432 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(F)(F)F)(C(F)(F)F)(F)F Question about this molecule: What is the physical state of this molecule? Option A: It is a clear, colorless gas. Option B: It is a colorless, odorless gas. Option C: It is a clear, colorless liquid. Option D: It is a clear, colorless syrupy liquid. " B 6423 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([N+](=O)[O-])(Cl)(Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It appears as a brown amorphous semi-solid, viscous oil or chunky golden yellow solid. Option B: It is a colorless, crystalline solid with a camphor-like odor. Option C: It appears as a slightly oily colorless to yellow liquid with a strong irritating odor. Option D: At room temperature and pressure, ortho- and meta-toluidines are viscous liquids, but para-toluidine is a flaky solid. " C 8035 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)CCC(=O)C Question about this molecule: What is the physical state of this molecule? Option A: It is a clear, colorless liquid with a pleasant odor. Option B: It appears as a clear colorless to yellow liquid with a bitter almond odor. Option C: It is a clear colorless oily liquid with a pleasant odor. Option D: It is a clear colorless to amber liquid with a sweet aromatic odor. " D 8174 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCO Question about this molecule: What is the physical state of this molecule? Option A: It appears as a clear colorless liquid with a sweet fat-like odor. Option B: It is a colorless, flammable liquid with a chloroform-like odor. Option C: It appears as a clear colorless liquid with a geranium-like odor. Option D: It is a colorless, crystalline solid with a camphor-like odor. " A 3347 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C(C1=CC=C(C=C1)Cl)C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3 Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to yellow slightly viscous liquid. Option B: It appears as a clear viscous yellow liquid with a mild odor. Option C: It is a colorless to slightly yellow viscous liquid. Option D: It is a slightly yellow viscous liquid. " B 2871 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OC1=CC2=C(C=C1)C(=C(C(=O)O2)Cl)C Question about this molecule: What is the physical state of this molecule? Option A: It appears as slightly brownish crystals with a slight sulfurous odor. Option B: It is a clear, slightly yellow liquid with a faint odor. Option C: It is a clear yellow slightly viscous liquid with a pungent odor. Option D: It is an odorless white to slightly yellow crystalline powder. " A 403 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1N)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as colorless crystals or granules or light gray powder. Option B: It appears as white or yellowish crystals or beige powder. Option C: It appears as white or reddish-yellow crystals or light brown powder. Option D: It appears as colorless to white monoclinic crystals or prisms or white powder. " C 7855 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC#N Question about this molecule: What is the physical state of this molecule? Option A: It is a clear colorless liquid. Option B: It appears as a colorless liquid. Option C: It is a colorless liquid. Option D: It is a dense colorless liquid. " C 24814 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: Cl[Sb](Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a low melting solid or viscous liquid. Option B: It is shipped as a solid or liquid solution. Option C: It appears as a crystalline solid or a liquid with a sharp odor. Option D: It is shipped as either a solid or liquid. " B 7482 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CCl)[N+](=O)[O-] Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless crystalline solid. Option B: It is a solid. Option C: It is a colorless crystalline solid. Option D: It is a crystalline solid. " B 8150 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCOCCOC Question about this molecule: What is the physical state of this molecule? Option A: It is a clear, colorless liquid with a pleasant odor. Option B: It is a colorless watery liquid with a pleasant odor. Option C: It is a clear colorless oily liquid with a pleasant odor. Option D: It is a colorless liquid with a mild pleasant odor. " B 6342 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC#N Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid with a mild pleasant odor. Option B: It appears as a colorless limpid liquid with an aromatic odor. Option C: It is a clear colorless oily liquid with a pleasant odor. Option D: It appears as a colorless liquid with a mild fruity odor. " B 13192 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCCN=C=O)CCN=C=O Question about this molecule: What is the physical state of this molecule? Option A: It occurs as a colorless to pale yellow solid. Option B: It appears as a colorless to pale yellow liquid. Option C: It is a pale yellow liquid. Option D: It is a clear, colorless to pale yellow liquid. " C 174 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CO)O Question about this molecule: What is the physical state of this molecule? Option A: It is a clear colorless liquid. Option B: It is a clear, colorless syrupy liquid. Option C: It appears as a clear colorless liquid. Option D: It is a clear, colorless liquid. " B 12217 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCOC(=O)CC Question about this molecule: What is the physical state of this molecule? Option A: It is a dense colorless liquid. Option B: It is a colorless liquid. Option C: It appears as a colorless liquid. Option D: It is a clear colorless liquid. " B 10178 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C1=C(C=C(C=C1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to straw-colored liquid. Option B: It sinks and mixes with water. Option C: It is a colorless to straw colored liquid. Option D: It can exist as dust in air. " D 8078 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCCCC1 Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It is a dense colorless liquid. Option C: It is a clear colorless liquid. Option D: It appears as a clear colorless liquid. " D 15910 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(#N)C1=C(C(=C(C(=C1Cl)Cl)Cl)C#N)Cl Question about this molecule: What is the physical state of this molecule? Option A: It appears as white or reddish-yellow crystals or light brown powder. Option B: It appears as colorless crystals or granules or light gray powder. Option C: It appears as colorless to white monoclinic crystals or prisms or white powder. Option D: It appears as white or yellowish crystals or beige powder. " B 5280450 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC/C=C\\C/C=C\\CCCCCCCC(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to straw colored liquid. Option B: It appears as a clear colorless liquid. Option C: It is a clear colorless liquid. Option D: It is a colorless to straw-colored liquid. " A 3032604 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)C(=O)/C(=C(\\C)/OP(=O)(OC)OC)/Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to pale yellow oily liquid. Option B: It is a colorless or slightly yellow oily liquid. Option C: It appears as a yellow oily liquid. Option D: It is a pale yellow oily liquid. " D 31070 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=O)(NC(C)C)OC1=CC(=C(C=C1)SC)C Question about this molecule: What is the physical state of this molecule? Option A: It appears as colorless crystals or white powder or chunky white solid. Option B: It appears as colorless crystals or light brown powder. Option C: It appears as a colorless to light tan crystalline powder or solid. Option D: It appears as brown waxy solid or colorless solid. " D 4075 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1N)C(=O)O)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a clear colorless aqueous solution. Option B: It is an odorless and colorless solid. Option C: Aqueous solutions acidic. Option D: It is an aqueous solution. " C 23690444 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)[O-])S.[Na+] Question about this molecule: What is the physical state of this molecule? Option A: It is a powder. Option B: It is a white powder. Option C: It is a white crystalline powder. Option D: It is a crystalline powder. " B 6327 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCl Question about this molecule: What is the physical state of this molecule? Option A: It is a clear, colorless liquid. Option B: It is a clear, colorless gas. Option C: It is a colorless, odorless gas. Option D: It is a clear, colorless syrupy liquid. " B 8086 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CNCC(C)O)O Question about this molecule: What is the physical state of this molecule? Option A: It sinks and mixes with water. Option B: It floats on water. Option C: Liquid or solid Option D: Liquid floats and mixes with water. " D 300 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)O)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to light-brown crystalline material. Option B: It is an odorless white to slightly yellow crystalline powder. Option C: It is an odorless white to light-yellow crystalline powder. Option D: It appears as a colorless to light tan crystalline powder or solid. " A 6351 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC1 Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It is a gas. Option C: It is a colorless gas. Option D: It is a colorless liquid. " C 637566 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC/C(=C/CO)/C)C Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to pale yellow oily liquid. Option B: It appears as a yellow oily liquid. Option C: It is a colorless or slightly yellow oily liquid. Option D: It is a pale yellow oily liquid. " A 7416 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless oily liquid. Option B: It is an oily liquid. Option C: It appears as an oily straw yellow clear liquid. Option D: It is an oily yellow liquid. " D 9584 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)N)F Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It is a dense colorless liquid. Option C: It is a colorless liquid. Option D: It is a clear liquid. " D 460 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC=CC=C1O Question about this molecule: What is the physical state of this molecule? Option A: It is a thick, oily liquid. Option B: It is a colorless oily liquid. Option C: It appears as a colorless oily liquid. Option D: It appears as a colorless, oily liquid. " A 31370 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CCl)O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to light yellow liquid. Option B: It is a clear colorless to light amber liquid. Option C: It is a colorless to light amber solid. Option D: It is a clear colorless to light yellow liquid. " B 12228 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN=C=O Question about this molecule: What is the physical state of this molecule? Option A: It is a low-boiling colorless, flammable liquid. Option B: It appears as a colorless low-boiling liquid. Option C: It is a colorless, mobile, flammable liquid. Option D: It is a colorless, flammable liquid. " B 11137 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC(=C1)O)[N+](=O)[O-] Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to yellow crystalline solid. Option B: It occurs as a colorless to pale yellow solid. Option C: It is a colorless to pale yellow crystalline solid. Option D: It appears as a colorless to pale yellow liquid. " C 5280970 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(/C=C\\Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to light amber solid. Option B: It is a clear colorless to light amber liquid. Option C: It is a clear colorless to light yellow liquid. Option D: It is a colorless to amber liquid. " D 516893 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(O)[O-].[K+] Question about this molecule: What is the physical state of this molecule? Option A: It is a white crystalline powder. Option B: It is a fine white crystalline solid. Option C: It is a white, crystalline substance. Option D: It is a white crystalline solid. " C 342 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC=C1)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It is a dense colorless liquid. Option C: It is a clear colorless liquid. Option D: It is a colorless liquid. " D 1004 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OP(=O)(O)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It appears as a liquid. Option C: It is a liquid. Option D: It is a clear liquid. " C 65482 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)C[C@H](CC[C@@H](C(=O)O)N)N)O)O)N Question about this molecule: What is the physical state of this molecule? Option A: It is a solid. Option B: It appears as a colorless crystalline solid. Option C: It is a colorless crystalline solid. Option D: It is a crystalline solid. " A 5943 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)(Cl)(Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a gas. Option B: It is a colorless gas. Option C: It appears as a colorless liquid. Option D: It is a colorless liquid. " B 178 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)N Question about this molecule: What is the physical state of this molecule? Option A: It appears as colorless monoclinic crystals. Option B: It appears as white crystals. Option C: It appears as golden crystals. Option D: It appears as colorless crystals. " D 1118 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OS(=O)(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless, slightly viscous liquid. Option B: It is a slightly yellow viscous liquid. Option C: It is a colorless to yellow slightly viscous liquid. Option D: It is a colorless to slightly yellow viscous liquid. " D 7505 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C#N Question about this molecule: What is the physical state of this molecule? Option A: It is a clear colorless liquid. Option B: It is a dense colorless liquid. Option C: It appears as a clear colorless liquid. Option D: It appears as a colorless liquid. " C 8189 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCOCCOCCOC Question about this molecule: What is the physical state of this molecule? Option A: It is a clear colorless liquid. Option B: It is a dense colorless liquid. Option C: It appears as a clear colorless liquid. Option D: It appears as a colorless liquid. " A 4754 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC1=CC=C(C=C1)NC(=O)C Question about this molecule: What is the physical state of this molecule? Option A: It is a white crystalline solid. Option B: It is a white crystalline powder. Option C: It is a fine white crystalline solid. Option D: It is a white crystalline powder or solid. " C 6115 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)N Question about this molecule: What is the physical state of this molecule? Option A: It is a slightly yellow viscous liquid. Option B: It is a clear to slightly yellow liquid. Option C: It is a colorless to yellow slightly viscous liquid. Option D: It is a colorless to slightly yellow viscous liquid. " B 17059 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C=CC(=C1)C2=CC(=C(C=C2)N=NC3=C(C4=C(C=C(C=C4C=C3S(=O)(=O)[O-])S(=O)(=O)[O-])N)O)OC)N=NC5=C(C6=C(C=C(C=C6C=C5S(=O)(=O)[O-])S(=O)(=O)[O-])N)O.[Na+].[Na+].[Na+].[Na+] Question about this molecule: What is the physical state of this molecule? Option A: It is a dark, yellow, oily liquid. Option B: It is a deep purple to dark blue microcrystalline powder. Option C: It is an odorless dark purple to blackish-brown powder. Option D: It is a clear light yellow to dark brown viscous liquid. " B 454 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCC=O Question about this molecule: What is the physical state of this molecule? Option A: It is a dense colorless liquid. Option B: It is a colorless liquid. Option C: It appears as a colorless liquid. Option D: It is a clear colorless liquid. " B 4116 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(C(Cl)Cl)(F)F Question about this molecule: What is the physical state of this molecule? Option A: It appears as a clear colorless liquid. Option B: It is a dense colorless liquid. Option C: It is a clear colorless liquid. Option D: It appears as a colorless liquid. " C 7111 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C2=CC=C(C=C2)N)N Question about this molecule: What is the physical state of this molecule? Option A: It is a crystalline solid. Option B: It is a colorless crystalline solid. Option C: It is a solution of a colorless crystalline solid. Option D: It appears as a colorless crystalline solid. " A 7835 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C(O1)CCl Question about this molecule: What is the physical state of this molecule? Option A: It is a dense colorless liquid. Option B: It appears as a clear colorless liquid. Option C: It is a clear colorless liquid. Option D: It appears as a colorless liquid. " B 54678486 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)CC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless crystalline solid. Option B: It is a solution of a colorless crystalline solid. Option C: It appears as a colorless crystalline solid. Option D: It is an odorless and colorless solid. " D 2354 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C(=N)N)NN=NC2=CC=C(C=C2)C(=N)N Question about this molecule: What is the physical state of this molecule? Option A: It is a crystalline solid. Option B: It appears as a colorless crystalline solid. Option C: It is a solid. Option D: It is a colorless crystalline solid. " C 7991 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid. Option B: It is a dense colorless liquid. Option C: It appears as a colorless liquid. Option D: It is a clear colorless liquid. " C 12695 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(F)(F)F)C(F)(F)F Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless gas. Option B: It appears as a colorless liquid. Option C: It is a colorless liquid. Option D: It is a gas. " A 10349 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CC(=O)O)C(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as white or yellowish crystals or beige powder. Option B: It appears as white to yellowish-white fine crystalline powder. Option C: It appears as colorless crystals or white powder or chunky white solid. Option D: It appears as colorless to white monoclinic crystals or prisms or white powder. " A 1678 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C[N+](=O)[O-])C(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as colorless monoclinic crystals. Option B: It appears as colorless crystals. Option C: It appears as white crystals. Option D: It appears as golden crystals. " D 3032791 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless to light tan crystalline powder or solid. Option B: It appears as colorless crystals or light brown powder. Option C: It appears as brown waxy solid or colorless solid. Option D: It appears as colorless crystals or white powder or chunky white solid. " B 880 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C=O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a clear colorless liquid with a sweet fat-like odor. Option B: It is a clear yellow slightly viscous liquid with a pungent odor. Option C: It appears as a colorless fuming liquid with a pungent odor. Option D: It appears as a clear colorless liquid with a geranium-like odor. " B 7966 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(CC1)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a clear colorless liquid with a sweet fat-like odor. Option B: It appears as a colorless liquid with a camphor-like odor. Option C: It is a colorless, flammable liquid with a chloroform-like odor. Option D: It appears as a clear colorless liquid with a geranium-like odor. " B 125468 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C=C(\\C)/C(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as odorless white powder or white glistening needles, usually melted together. Option B: It appears as white, beige or slightly yellow waxy solid with an aromatic odor and a slightly bitter burning taste. Option C: It appears as a white lustrous flaked solid with a fruity or spicy odor. Option D: It appears as white or reddish-yellow crystals or light brown powder. " C 398 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[N+](=O)[O-] Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid with a mild pleasant odor. Option B: It is a clear colorless oily liquid with a pleasant odor. Option C: It appears as a colorless liquid with a mild fruity odor. Option D: It is a clear, colorless liquid with a pleasant odor. " C 281 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C-]#[O+] Question about this molecule: What is the physical state of this molecule? Option A: It appears as a clear colorless liquid with a sweet fat-like odor. Option B: It is a colorless, nonirritating, odorless, and tasteless gas. Option C: It is a colorless, flammable liquid with a chloroform-like odor. Option D: It appears as a clear colorless liquid with a geranium-like odor. " B 240 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C=O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a clear colorless to yellow liquid with a bitter almond odor. Option B: It is a clear colorless oily liquid with a pleasant odor. Option C: It is a clear colorless to amber liquid with a sweet aromatic odor. Option D: It is a clear, colorless liquid with a pleasant odor. " A 23677060 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O[As](=O)(O)[O-].[Na+] Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless to white lustrous solid. Option B: It is a colorless to pale yellow crystalline solid. Option C: It appears as a colorless to white crystalline solid. Option D: It is a colorless to white crystalline solid. " D 11638 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CF Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless nonflammable gas. Option B: It is a colorless flammable highly toxic gas. Option C: It is a colorless flammable gas. Option D: It is a colorless flammable gas which is heavier than air. " D 7108 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)NC3=CC=CC=C3S2 Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless to white crystalline solid. Option B: It is a white crystalline powder or solid. Option C: It appears as a colorless to light tan crystalline powder or solid. Option D: It is a light green to steel-blue powder. " D 162637 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C@@H]([C@H](C(=O)[O-])O)(C(=O)[O-])O.[Na+].[Na+] Question about this molecule: What is the physical state of this molecule? Option A: It appears as a white crystalline, odorless powder. Option B: It is identified by transparent, colorless, and odorless crystals. Option C: It is an odorless white to slightly yellow crystalline powder. Option D: It is an odorless white to light-yellow crystalline powder. " B 6259 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(=O)CBr Question about this molecule: What is the physical state of this molecule? Option A: It is a clear colorless oily liquid with a pleasant odor. Option B: It is a clear, colorless liquid with a pleasant odor. Option C: It is a colorless liquid with a mild pleasant odor. Option D: It appears as a crystalline solid or a liquid with a sharp odor. " D 7859 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C#CCO Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless, flammable liquid with a chloroform-like odor. Option B: It appears as a clear colorless liquid with a geranium-like odor. Option C: It is a colorless, crystalline solid with a camphor-like odor. Option D: It appears as a clear colorless liquid with a sweet fat-like odor. " B 650 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C(=O)C Question about this molecule: What is the physical state of this molecule? Option A: It appears as a clear colorless liquid with a strong chlorine-like odor. Option B: It is a clear colorless liquid with an overpowering fruity-like odor. Option C: It is a clear colorless mobile liquid with a pleasant lemon-like odor. Option D: It appears as a clear colorless liquid with a sweet fat-like odor. " A 7839 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CBr)Br Question about this molecule: What is the physical state of this molecule? Option A: It appears as a liquid. Option B: It is a liquid. Option C: It is a clear liquid. Option D: It appears as a colorless liquid. " B 8900 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCC Question about this molecule: What is the physical state of this molecule? Option A: It is a liquid. Option B: It is a clear liquid. Option C: It appears as a liquid. Option D: It appears as a colorless liquid. " A 6323 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CBr Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless liquid. Option B: It is a gas. Option C: It appears as a colorless liquid. Option D: It is a colorless gas. " B 1032 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It is a liquid. Option C: It is a clear liquid. Option D: It appears as a liquid. " B 8037 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCN(C)C Question about this molecule: What is the physical state of this molecule? Option A: It is a liquid. Option B: It appears as a liquid. Option C: It appears as a colorless liquid. Option D: It is a clear liquid. " A 2682 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCCCCCO Question about this molecule: What is the physical state of this molecule? Option A: It is a colorless crystalline solid. Option B: It is a crystalline solid. Option C: It is a solid. Option D: It appears as a colorless crystalline solid. " C 8452 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(=O)C1 Question about this molecule: What is the physical state of this molecule? Option A: It is a liquid. Option B: It appears as a colorless liquid. Option C: It appears as a liquid. Option D: It is a clear liquid. " A 7040 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CC=C1N=C=O)N=C=O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It appears as a liquid. Option C: It is a clear liquid. Option D: It is a liquid. " D 8496 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC(=C1)C(=O)O)C(=O)O Question about this molecule: What is the physical state of this molecule? Option A: It is a crystalline solid. Option B: It is a solid. Option C: It is a colorless crystalline solid. Option D: It appears as a colorless crystalline solid. " B 751 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(C=O)O)O Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless crystalline solid. Option B: It is a crystalline solid. Option C: It is a solid. Option D: It is a colorless crystalline solid. " C 8343 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It is a liquid. Option C: It appears as a liquid. Option D: It is a clear liquid. " B 13676 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(CC)SC1=CC=CC=C1 Question about this molecule: What is the physical state of this molecule? Option A: It appears as a liquid. Option B: It appears as a colorless liquid. Option C: It is a liquid. Option D: It is a clear liquid. " C 1146 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C Question about this molecule: What is the physical state of this molecule? Option A: It is a clear liquid. Option B: It appears as a liquid. Option C: It is a liquid. Option D: It appears as a colorless liquid. " C 8051 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC(=O)C Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It is a colorless liquid. Option C: It sinks and mixes with water. Option D: It floats on water. " D 568 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C3=CC=CC=C3O2 Question about this molecule: What is the physical state of this molecule? Option A: It is a crystalline solid. Option B: It appears as a colorless crystalline solid. Option C: It is a colorless crystalline solid. Option D: It is a solid. " D 9427 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=O)NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)F Question about this molecule: What is the physical state of this molecule? Option A: It is a crystalline solid. Option B: It appears as a colorless crystalline solid. Option C: It is a colorless crystalline solid. Option D: It is a solid. " D 3485 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC=O)CC=O Question about this molecule: What is the physical state of this molecule? Option A: It is a liquid. Option B: It appears as a liquid. Option C: It is a clear liquid. Option D: It appears as a colorless liquid. " A 33528 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCN1C(=O)C=CS1 Question about this molecule: What is the physical state of this molecule? Option A: It is a liquid. Option B: It is a clear liquid. Option C: It appears as a liquid. Option D: It appears as a colorless liquid. " A 3026 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC Question about this molecule: What is the physical state of this molecule? Option A: It is a liquid. Option B: It appears as a liquid. Option C: It appears as a colorless liquid. Option D: It is a clear liquid. " A 783 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [HH] Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It is a gas. Option C: It is a colorless liquid. Option D: It is a colorless gas. " B 24386 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=S(Cl)Cl Question about this molecule: What is the physical state of this molecule? Option A: It is a liquid. Option B: It is a clear liquid. Option C: It appears as a liquid. Option D: It appears as a colorless liquid. " A 7573 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NC1=CC=C(C=C1)NC2=CC=CC=C2 Question about this molecule: What is the physical state of this molecule? Option A: It is a crystalline solid. Option B: It is a colorless crystalline solid. Option C: It appears as a colorless crystalline solid. Option D: It is a solid. " D 2537 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C2CCC1(C(=O)C2)C)C Question about this molecule: What is the physical state of this molecule? Option A: It is a crystalline powder. Option B: It is a powder. Option C: It is a white powder. Option D: It is a white crystalline powder. " A 4114 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2 Question about this molecule: What is the physical state of this molecule? Option A: It is a solid. Option B: It is a crystalline solid. Option C: It appears as a colorless crystalline solid. Option D: It is a colorless crystalline solid. " A 12232 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CSSC Question about this molecule: What is the physical state of this molecule? Option A: It appears as a colorless liquid. Option B: It is a liquid. Option C: It is a clear liquid. Option D: It appears as a liquid. " B 1054 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NC=C(C(=C1O)CO)CO Question about this molecule: What is the right information about this molecule's physiological effect? Option A: It may cause anemia, nerve damage, seizures, skin problems, and sores in the mouth. Option B: It is associated with a diabetic-like state, impaired growth, decreased fertility, and increased risk of cardiovascular diseases. Option C: It is noted in abnormal liver function, renal dialysis patients, and severe to moderate muscular weakness with associated anorexia. Option D: It is associated with neurological manifestations, skin rash, hair loss, and metabolic disturbances. " A 6013 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=CC(=O)CC[C@]34C Question about this molecule: What is the right information about this molecule's physiological effect? Option A: It may cause anemia, nerve damage, seizures, skin problems, and sores in the mouth. Option B: It can lead to anemia in animals and erythrocytosis in humans. Option C: It may cause neurological dysfunction and lameness. Option D: It may cause deficiency in older men. " D 6288 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]([C@@H](C(=O)O)N)O Question about this molecule: What is the right information about this molecule's physiological effect? Option A: It may cause neurological dysfunction and lameness. Option B: It can lead to anemia in animals and erythrocytosis in humans. Option C: It may cause anemia, nerve damage, seizures, skin problems, and sores in the mouth. Option D: It is associated with neurological manifestations, skin rash, hair loss, and metabolic disturbances. " A 271 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Ca+2] Question about this molecule: What is the right information about this molecule's physiological effect? Option A: It can lead to anemia in animals and erythrocytosis in humans. Option B: It can affect bone and tooth formation and cause kidney stones. Option C: It is associated with neurological manifestations, skin rash, hair loss, and metabolic disturbances. Option D: It may cause neurological dysfunction and lameness. " B 171548 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@H]2[C@@H]([C@@H](S1)CCCCC(=O)O)NC(=O)N2 Question about this molecule: What is the right information about this molecule's physiological effect? Option A: It may cause anemia, nerve damage, seizures, skin problems, and sores in the mouth. Option B: It is noted in abnormal liver function, renal dialysis patients, and severe to moderate muscular weakness with associated anorexia. Option C: It is associated with neurological manifestations, skin rash, hair loss, and metabolic disturbances. Option D: It is associated with a diabetic-like state, impaired growth, decreased fertility, and increased risk of cardiovascular diseases. " C 29936 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Fe+3] Question about this molecule: What is the right information about this molecule's physiological effect? Option A: It may cause anemia, nerve damage, seizures, skin problems, and sores in the mouth. Option B: It is associated with a diabetic-like state, impaired growth, decreased fertility, and increased risk of cardiovascular diseases. Option C: It is the most common nutritional deficiency worldwide, particularly affecting children, women of childbearing age, and pregnant women. Option D: It is noted in abnormal liver function, renal dialysis patients, and severe to moderate muscular weakness with associated anorexia. " C 104730 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Co] Question about this molecule: What is the right information about this molecule's physiological effect? Option A: It may cause anemia, nerve damage, seizures, skin problems, and sores in the mouth. Option B: It can lead to anemia in animals and erythrocytosis in humans. Option C: It is associated with a diabetic-like state, impaired growth, decreased fertility, and increased risk of cardiovascular diseases. Option D: It is associated with neurological manifestations, skin rash, hair loss, and metabolic disturbances. " B 23976 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Cr] Question about this molecule: What is the right information about this molecule's physiological effect? Option A: It is the most common nutritional deficiency worldwide, particularly affecting children, women of childbearing age, and pregnant women. Option B: It may cause anemia, nerve damage, seizures, skin problems, and sores in the mouth. Option C: It is associated with a diabetic-like state, impaired growth, decreased fertility, and increased risk of cardiovascular diseases. Option D: It is noted in abnormal liver function, renal dialysis patients, and severe to moderate muscular weakness with associated anorexia. " C 10917 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+](C)(C)C[C@@H](CC(=O)[O-])O Question about this molecule: What is the right information about this molecule's physiological effect? Option A: It may cause anemia, nerve damage, seizures, skin problems, and sores in the mouth. Option B: It is the most common nutritional deficiency worldwide, particularly affecting children, women of childbearing age, and pregnant women. Option C: It is noted in abnormal liver function, renal dialysis patients, and severe to moderate muscular weakness with associated anorexia. Option D: It is associated with a diabetic-like state, impaired growth, decreased fertility, and increased risk of cardiovascular diseases. " C 121596207 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=O)[C@]2([C@@H]([C@@H]1OC(=O)C)O2)C/C=C(\\C)/CC/C=C(\\C)/CC/C=C(\\C)/CO Question about this molecule: Which kind of potency does this molecule have/exhibit? Option A: It is a cell-permeable, potent and selective agonist of the TRPV4 (transient receptor potential vanilloid 4) channel. Option B: It is the more potent enantiomer of racemic sarin, a nerve agent. Option C: It shows antifungal activity towards the pathogenic yeast Candida albicans. Option D: It is about 3 times more potent than the mixture of atracurium isomers as a neuromuscular blocking agent. " C 5288826 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](C=C4)O Question about this molecule: Which kind of potency does this molecule have/exhibit? Option A: It is a highly potent, selective and orally bioavailable Porcupine inhibitor. Option B: It is the more potent enantiomer of racemic sarin, a nerve agent. Option C: It is about 3 times more potent than the mixture of atracurium isomers as a neuromuscular blocking agent. Option D: It is a highly potent opiate analgesic psychoactive drug. " D 60838 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7 Question about this molecule: Which kind of potency does this molecule have/exhibit? Option A: It is 2 fold more potent against cyclin dependent kinase 5 (CDK5) and >150 times more potent against CDK1. Option B: It is a prodrug that is converted to its active metabolite, SN-38, which is ~1000 times more active. Option C: It is a cell-permeable, potent and selective agonist of the TRPV4 (transient receptor potential vanilloid 4) channel. Option D: It is an acetylcholinesterase (AChE) inhibitor (IC50 0.40 nM, >1,000 times more potent than tacrine). " B 12315315 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)O[P@@](=O)(C)F Question about this molecule: Which kind of potency does this molecule have/exhibit? Option A: It is about 3 times more potent than the mixture of atracurium isomers as a neuromuscular blocking agent. Option B: It is an acetylcholinesterase (AChE) inhibitor (IC50 0.40 nM, >1,000 times more potent than tacrine). Option C: It is the more potent enantiomer of racemic sarin, a nerve agent. Option D: It is a cell-permeable, potent and selective agonist of the TRPV4 (transient receptor potential vanilloid 4) channel. " C 5311065 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C[C@H](N(C1)C(=O)[C@@H]2CSSCCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(=O)N Question about this molecule: What is the potency of this molecule? Option A: It possesses greater potency than endogenous LHRH and reversibly represses gonadotropin secretion. Option B: It displays enhanced antidiuretic potency compared to endogenous ADH. Option C: It is approximately 10 times more potent than navitoclax with regard to induction of apoptosis in CLL cells. Option D: It mimics the actions of endogenous progesterone with a greater potency. " B 3826 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O Question about this molecule: What is the potency of this molecule? Option A: It displays enhanced antidiuretic potency compared to endogenous ADH. Option B: It mimics the actions of endogenous progesterone with a greater potency. Option C: It is a potent nonsteroidal antiinflammatory drug (NSAID). Option D: It is one of the most potent NSAIDs in blocking prostaglandin synthesis. " C 6918837 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO Question about this molecule: What is the potency of this molecule? Option A: It is considered the most potent. Option B: It is considered the most potent statin medication. Option C: It is the most potent CCB in use. Option D: It is the most potent DAC inhibiting agent available on the market. " D 34328 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(CCC1(C2=CC=CC=C2)C(=O)O)CCC(C#N)(C3=CC=CC=C3)C4=CC=CC=C4 Question about this molecule: What is the potency of this molecule? Option A: It displays enhanced antidiuretic potency compared to endogenous ADH. Option B: It mimics the actions of endogenous progesterone with a greater potency. Option C: The antidiarrheal potency of it is much greater than its CNS effects. Option D: It possesses greater potency than endogenous LHRH and reversibly represses gonadotropin secretion. " C 446157 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C1=NC(=NC(=C1/C=C/[C@H](C[C@H](CC(=O)O)O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C Question about this molecule: What is the potency of this molecule? Option A: It is considered the most potent. Option B: It is the most potent CCB in use. Option C: It is considered the most potent statin medication. Option D: It is a more potent inhibitor. " C 3325 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(N=C(S1)N=C(N)N)CSCCC(=NS(=O)(=O)N)N Question about this molecule: What is the potency of this molecule? Option A: It has a significantly higher barrier to resistance than the first generation NS5A inhibitors, making it a highly potent and reliable alternative for treatment of chronic Hepatitis C. Option B: It is more potent and is safer than the synthetic estrogen ethinylestradiol (EE2) found in 97% of oral contraceptive pills. Option C: It is approximately 10 times more potent than navitoclax with regard to induction of apoptosis in CLL cells. Option D: It is about 20 to 50 times more potent at inhibiting gastric acid secretion than cimetidine and eight times more potent than ranitidine on a weight basis. " D 9395 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=O)(OCC)OC1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: What is the potency of this molecule? Option A: It possesses greater potency than endogenous LHRH and reversibly represses gonadotropin secretion. Option B: It has a significantly higher barrier to resistance than the first generation NS5A inhibitors, making it a highly potent and reliable alternative for treatment of chronic Hepatitis C. Option C: It is approximately 10 times more potent than navitoclax with regard to induction of apoptosis in CLL cells. Option D: It is one of the most potent acetylcholinesterase-inhibiting insecticides available. " D 6451164 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)/C=C/C#N Question about this molecule: What is the potency of this molecule? Option A: It has a very high potency compared to other NNRTI's. Option B: It possesses greater potency than endogenous LHRH and reversibly represses gonadotropin secretion. Option C: It mimics the actions of endogenous progesterone with a greater potency. Option D: It displays enhanced antidiuretic potency compared to endogenous ADH. " A 5284603 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)OC)O4)O Question about this molecule: What is the potency of this molecule? Option A: It is more potent and more addicting than codeine by weight. Option B: It is more potent than morphine. Option C: It is more potent and addicting than codeine. Option D: It is estimated to be between 400-6000 times more potent than morphine in certain cases. " C 54688261 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C[C@@H](C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)O Question about this molecule: What is the potency of this molecule? Option A: It is 2-5 times more potent than the R-isomer in producing an anticoagulant response. Option B: S-warfarin is 2-5 times more potent than the R-isomer in producing an anticoagulant response. Option C: It is approximately 10 times more potent than navitoclax with regard to induction of apoptosis in CLL cells. Option D: It is approximately 13 per cent less potent (by molarity) than racemic bupivacaine. " B 5311052 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@H]1C(=O)CO)C)O)Cl)C)F Question about this molecule: What is the potency of this molecule? Option A: It is a medium potency corticosteroid. Option B: It is one of the most potent NSAIDs in blocking prostaglandin synthesis. Option C: It is a moderately potent difluorinated corticosteroid ester. Option D: It is a potent nonsteroidal antiinflammatory drug (NSAID). " A 10635 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CCC(=O)C[C@@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@H]4O)C Question about this molecule: What is the potency of this molecule? Option A: It is estimated to be between 400-6000 times more potent than morphine in certain cases. Option B: It is less potent than remdesivir against a number of viruses. Option C: It is approximately 150 times more potent than citalopram's R-enantiomer. Option D: DHT is approximately 30 times more potent than testosterone. " D 45375808 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3 Question about this molecule: What is the potency of this molecule? Option A: It displays enhanced antidiuretic potency compared to endogenous ADH. Option B: It mimics the actions of endogenous progesterone with a greater potency. Option C: It is a very potent option for the treatment of Hepatitis C. Option D: It is the most potent DAC inhibiting agent available on the market. " C 6230 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC(=O)CC[C@H]34 Question about this molecule: What is the potency of this molecule? Option A: It mimics the actions of endogenous progesterone with a greater potency. Option B: It possesses greater potency than endogenous LHRH and reversibly represses gonadotropin secretion. Option C: It is approximately 10 times more potent than navitoclax with regard to induction of apoptosis in CLL cells. Option D: It has a significantly higher barrier to resistance than the first generation NS5A inhibitors, making it a highly potent and reliable alternative for treatment of chronic Hepatitis C. " A 5702546 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@]2([C@H]3[C@H]4[C@]1([C@@H]5C=C(C(=O)[C@]5(CC(=C4)COC(=O)CC6=CC(=C(C=C6)O)OC)O)C)O[C@](O3)(O2)CC7=CC=CC=C7)C(=C)C Question about this molecule: What is the potency of this molecule? Option A: It is approximately 10-fold more potent than aminocaproic acid. Option B: It is an ultrapotent capsaicin analog. Option C: DHT is approximately 30 times more potent than testosterone. Option D: It is estimated to be between 400-6000 times more potent than morphine in certain cases. " B 92253 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCN1CCCC[C@H]1C(=O)NC2=C(C=CC=C2C)C Question about this molecule: What is the potency of this molecule? Option A: It is approximately 10 times more potent than navitoclax with regard to induction of apoptosis in CLL cells. Option B: It is three times more potent than desflurane, but has lower potency compared to halothane and isoflurane. Option C: It is approximately 13 per cent less potent (by molarity) than racemic bupivacaine. Option D: It has a significantly higher barrier to resistance than the first generation NS5A inhibitors, making it a highly potent and reliable alternative for treatment of chronic Hepatitis C. " C 6446 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@]2([C@H](C[C@]4([C@H]3CC[C@]4(C)O)C)O)F Question about this molecule: What is the potency of this molecule? Option A: It is estimated to be between 400-6000 times more potent than morphine in certain cases. Option B: It is approximately 5 times as potent as natural methyltestosterone. Option C: It is more potent than morphine. Option D: DHT is approximately 30 times more potent than testosterone. " B 6011 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@]2([C@@H](CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@H]4O)C)CC1=O)C Question about this molecule: What is the potency of this molecule? Option A: DHT is approximately 30 times more potent than testosterone. Option B: It is more potent than morphine. Option C: It is approximately 5 times as potent as natural methyltestosterone. Option D: It is estimated to be between 400-6000 times more potent than morphine in certain cases. " C 16490 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C)F Question about this molecule: What is the potency of this molecule? Option A: It mimics the actions of endogenous progesterone with a greater potency. Option B: It is one of the most potent acetylcholinesterase-inhibiting insecticides available. Option C: It possesses greater potency than endogenous LHRH and reversibly represses gonadotropin secretion. Option D: It is a moderately potent difluorinated corticosteroid ester. " D 443884 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](CO)NC(=O)[C@H]1CN([C@@H]2CC3=CNC4=CC=CC(=C34)C2=C1)C Question about this molecule: What is the potency of this molecule? Option A: It is estimated to be between 400-6000 times more potent than morphine in certain cases. Option B: It has been shown to be more potent than diazepam or nitrazepam. Option C: It is less potent than remdesivir against a number of viruses. Option D: It is a less potent vasoconstrictor than ergotamine. " D 71496458 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC Question about this molecule: What is the potency of this molecule? Option A: It is a more potent inhibitor. Option B: It is the most potent CCB in use. Option C: It is considered the most potent statin medication. Option D: It is considered the most potent. " A 3333 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C Question about this molecule: What is the potency of this molecule? Option A: It is the most potent CCB in use. Option B: It is considered the most potent. Option C: It is the most potent DAC inhibiting agent available on the market. Option D: It is considered the most potent statin medication. " A 54454 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C)(C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C Question about this molecule: What is the potency of this molecule? Option A: It is the most potent CCB in use. Option B: It is considered the most potent. Option C: It is considered the most potent statin medication. Option D: It is a more potent inhibitor. " B 3261 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C2=NN=CN2C3=C(C=C(C=C3)Cl)C(=N1)C4=CC=CC=C4 Question about this molecule: What is the potency of this molecule? Option A: It has been shown to be more potent than diazepam or nitrazepam. Option B: It is less potent than remdesivir against a number of viruses. Option C: It is approximately 13 per cent less potent (by molarity) than racemic bupivacaine. Option D: It is approximately 10 times more potent than navitoclax with regard to induction of apoptosis in CLL cells. " A 23665760 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]Cl.[Na+] Question about this molecule: What is the potency of this molecule? Option A: It is considered the most potent. Option B: It is particularly effective. Option C: It is considered the most potent statin medication. Option D: It is a more potent inhibitor. " B 3715 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O Question about this molecule: What is the potency of this molecule? Option A: It displays enhanced antidiuretic potency compared to endogenous ADH. Option B: It is a potent nonsteroidal antiinflammatory drug (NSAID). Option C: It mimics the actions of endogenous progesterone with a greater potency. Option D: It is one of the most potent NSAIDs in blocking prostaglandin synthesis. " D 5526 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC(CCC1CN)C(=O)O Question about this molecule: What is the potency of this molecule? Option A: It is approximately 150 times more potent than citalopram's R-enantiomer. Option B: DHT is approximately 30 times more potent than testosterone. Option C: It is approximately 10-fold more potent than aminocaproic acid. Option D: It is estimated to be between 400-6000 times more potent than morphine in certain cases. " C 54684598 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C[C@H](C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)O Question about this molecule: What is the potency of this molecule? Option A: S-warfarin is 2-5 times more potent than the R-isomer in producing an anticoagulant response. Option B: It is approximately 10 times more potent than navitoclax with regard to induction of apoptosis in CLL cells. Option C: It is approximately 13 per cent less potent (by molarity) than racemic bupivacaine. Option D: It is 2-5 times more potent than the R-isomer in producing an anticoagulant response. " D 45266502 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC[C@@](C)(/C=C/[C@H]1[C@H](C[C@@H]([C@@H]1C/C=C\\CCCC(=O)[O-])O)O)O.C(C(CO)(CO)[NH3+])O Question about this molecule: What is the potency of this molecule? Option A: It is ranked as the most effective among six commonly prescribed antidepressants. Option B: It is effective in both the first and second trimesters of pregnancy. Option C: It is usually not effective for more than 7 days. Option D: It can be effective for weeks when applied to indoor inert surfaces. " B 62156 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCC3=CC=CC=C3)C(=O)OC Question about this molecule: What is the potency of this molecule? Option A: It is the most potent DAC inhibiting agent available on the market. Option B: It mimics the actions of endogenous progesterone with a greater potency. Option C: It is one of the most potent opioids known (also the most potent opioid used commercially). Option D: It is one of the most potent NSAIDs in blocking prostaglandin synthesis. " C 27125 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1[C@H]([C@H]([C@@H]2O)O)O)CCC4=C3C=CC(=C4)O Question about this molecule: What is the potency of this molecule? Option A: It is about 20 to 50 times more potent at inhibiting gastric acid secretion than cimetidine and eight times more potent than ranitidine on a weight basis. Option B: It has a significantly higher barrier to resistance than the first generation NS5A inhibitors, making it a highly potent and reliable alternative for treatment of chronic Hepatitis C. Option C: It is approximately 10 times more potent than navitoclax with regard to induction of apoptosis in CLL cells. Option D: It is more potent and is safer than the synthetic estrogen ethinylestradiol (EE2) found in 97% of oral contraceptive pills. " D 5656 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O Question about this molecule: What is the potency of this molecule? Option A: It is ranked as the most effective among six commonly prescribed antidepressants. Option B: It is the most potent DAC inhibiting agent available on the market. Option C: It is one of the most potent NSAIDs in blocking prostaglandin synthesis. Option D: It is one of the most potent opioids known (also the most potent opioid used commercially). " A 2249 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(COC1=CC=C(C=C1)CC(=O)N)O Question about this molecule: What is the potency of this molecule? Option A: It has a significantly higher barrier to resistance than the first generation NS5A inhibitors, making it a highly potent and reliable alternative for treatment of chronic Hepatitis C. Option B: It is approximately 10 times more potent than navitoclax with regard to induction of apoptosis in CLL cells. Option C: It may not significantly reduce mortality and only modestly reduce the risk of cardiovascular disease in patients with hypertension. Option D: It possesses greater potency than endogenous LHRH and reversibly represses gonadotropin secretion. " C 5282452 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC1C2=NC3=CC=CC=C3C(=C2/C=C/[C@H](C[C@H](CC(=O)O)O)O)C4=CC=C(C=C4)F Question about this molecule: What is the potency of this molecule? Option A: It is the most potent CCB in use. Option B: It is a more potent inhibitor. Option C: It is considered the most potent. Option D: It is considered the most potent statin medication. " D 5284569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3C(=O)CC4 Question about this molecule: What is the potency of this molecule? Option A: It is more potent and addicting than codeine. Option B: It is more potent than morphine. Option C: It is more potent and more addicting than codeine by weight. Option D: It is estimated to be between 400-6000 times more potent than morphine in certain cases. " C 3284 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C#CC1(CCCCC1)OC(=O)N Question about this molecule: What is the potency of this molecule? Option A: It is usually not effective for more than 7 days. Option B: It can be effective for weeks when applied to indoor inert surfaces. Option C: It is estimated to be between 400-6000 times more potent than morphine in certain cases. Option D: DHT is approximately 30 times more potent than testosterone. " A 33741 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C[C@H]1CCCC[C@@]1(C2=CC(=CC=C2)OC)O Question about this molecule: What is the potency of this molecule? Option A: It is the most potent DAC inhibiting agent available on the market. Option B: It is more potent than morphine. Option C: It has about 1/10th of the potency of morphine. Option D: It is estimated to be between 400-6000 times more potent than morphine in certain cases. " C 44468216 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C2C(=NC=NN2C(=C1)[C@]3([C@@H]([C@@H]([C@H](O3)CO)O)O)C#N)N Question about this molecule: What is the potency of this molecule? Option A: It has been shown to be more potent than diazepam or nitrazepam. Option B: It is approximately 10 times more potent than navitoclax with regard to induction of apoptosis in CLL cells. Option C: It is less potent than remdesivir against a number of viruses. Option D: It is approximately 13 per cent less potent (by molarity) than racemic bupivacaine. " C 5206 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(OC(C(F)(F)F)C(F)(F)F)F Question about this molecule: What is the potency of this molecule? Option A: It possesses greater potency than endogenous LHRH and reversibly represses gonadotropin secretion. Option B: It is approximately 10 times more potent than navitoclax with regard to induction of apoptosis in CLL cells. Option C: It is three times more potent than desflurane, but has lower potency compared to halothane and isoflurane. Option D: It has a significantly higher barrier to resistance than the first generation NS5A inhibitors, making it a highly potent and reliable alternative for treatment of chronic Hepatitis C. " C 4075 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1N)C(=O)O)O Question about this molecule: What is the potency of this molecule? Option A: It has approximately 3 times its neuromuscular blocking potency. Option B: It is effective in treating and maintaining remission for ulcerative colitis. Option C: It is the most potent DAC inhibiting agent available on the market. Option D: It can be effective for weeks when applied to indoor inert surfaces. " B 2912 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C(C1C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C=C(Cl)Cl)C Question about this molecule: What is the potency of this molecule? Option A: DHT is approximately 30 times more potent than testosterone. Option B: It is estimated to be between 400-6000 times more potent than morphine in certain cases. Option C: It is usually not effective for more than 7 days. Option D: It can be effective for weeks when applied to indoor inert surfaces. " D 146570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCC[C@@]1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F Question about this molecule: What is the potency of this molecule? Option A: It is estimated to be between 400-6000 times more potent than morphine in certain cases. Option B: DHT is approximately 30 times more potent than testosterone. Option C: It is approximately 150 times more potent than citalopram's R-enantiomer. Option D: It is less potent than remdesivir against a number of viruses. " C 53232 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C Question about this molecule: What is the potency of this molecule? Option A: It is estimated to be between 400-6000 times more potent than morphine in certain cases. Option B: It is 2 times more potent than mevastatin. Option C: It is approximately 150 times more potent than citalopram's R-enantiomer. Option D: DHT is approximately 30 times more potent than testosterone. " B 61996 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)N(C1CCN(CC1C)CCC2=CC=CC=C2)C3=CC=CC=C3 Question about this molecule: What is the potency of this molecule? Option A: It is less potent than remdesivir against a number of viruses. Option B: It is approximately 150 times more potent than citalopram's R-enantiomer. Option C: It is estimated to be between 400-6000 times more potent than morphine in certain cases. Option D: DHT is approximately 30 times more potent than testosterone. " C 5284570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3C(=O)CC4 Question about this molecule: What is the potency of this molecule? Option A: It is more potent than morphine. Option B: It is more potent and addicting than codeine. Option C: It is more potent and more addicting than codeine by weight. Option D: It is estimated to be between 400-6000 times more potent than morphine in certain cases. " A 5991 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=C3C=CC(=C4)O Question about this molecule: What is the potency of this molecule? Option A: It has high estrogenic potency when administered orally. Option B: It exhibits potency that is 50-450 times higher than that of the first generation VEGFR inhibitors. Option C: It is estimated to be between 400-6000 times more potent than morphine in certain cases. Option D: It has approximately 3 times its neuromuscular blocking potency. " A 3100 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2 Question about this molecule: What is the potency of this molecule? Option A: It is ranked as the most effective among six commonly prescribed antidepressants. Option B: It is one of the most potent opioids known (also the most potent opioid used commercially). Option C: It is the most effective antihistamine available. Option D: It is the most potent DAC inhibiting agent available on the market. " C 8029 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=COC=C1 Question about this molecule: Which kind of reaction can this molecule cause? Option A: It can replace inorganic phosphate in the step of glycolysis that produces 1,3-bisphosphoglycerate. Option B: It can react with carbon dioxide (CO2) via a reversible reaction to form a carbamic acid. Option C: It can induce a rearrangement reaction to 4,4'-benzidine when treated with mineral acids. Option D: It can cause thiophene formation reaction of 1,4-diketones with Lawesson's reagent. " D 11443 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)N=C=O)N=C=O Question about this molecule: Which kind of reaction can this molecule cause? Option A: It can cause chronic inhalation exposure resulting in significant decreases in lung function in workers, an asthma-like reaction characterized by wheezing, dyspnea, and bronchial constriction. Option B: It can block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option C: It can cause decarboxylation of phenylpyruvate to give phenylacetate and reduction reaction to give phenyllactate. Option D: It can cause the formation of a highly reactive methyl diazonium cation capable of methylating various residues on adenosine and guanine bases leading to DNA lesions and eventual apoptosis. " A 943 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N+](=O)([O-])[O-] Question about this molecule: Which kind of reaction can this molecule cause? Option A: It can undergo oxidation/reduction (redox) reactions and form cystine when oxidized, which is two this molecule residues joined by a disulfide bond. Option B: It can cause chronic inhalation exposure resulting in significant decreases in lung function in workers, an asthma-like reaction characterized by wheezing, dyspnea, and bronchial constriction. Option C: It can cause oxidation of the iron atoms in hemoglobin from Ferrous Iron (2+) to Ferric Iron (3+), rendering it unable to carry oxygen. Option D: It can cause the formation of a highly reactive methyl diazonium cation capable of methylating various residues on adenosine and guanine bases leading to DNA lesions and eventual apoptosis. " C 674 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC Question about this molecule: Which kind of reaction can this molecule cause? Option A: It can undergo nitrosation under weak acid conditions to give dimethlynitrosamine. Option B: It can undergo oxidation/reduction (redox) reactions and form cystine when oxidized, which is two this molecule residues joined by a disulfide bond. Option C: It can cause decarboxylation of phenylpyruvate to give phenylacetate and reduction reaction to give phenyllactate. Option D: It can cause thiophene formation reaction of 1,4-diketones with Lawesson's reagent. " A 934 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Ni+2] Question about this molecule: Which kind of reaction can this molecule cause? Option A: It can react with thiols as a Michael acceptor. Option B: It can cause redox reactions and conjugation reactions. Option C: It can cause allergic reactions. Option D: It can cause allergic reactions, although only rarely. " C 5280795 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](CCCC(C)C)[C@H]1CC[C@@H]\\2[C@@]1(CCC/C2=C\\C=C/3\\C[C@H](CCC3=C)O)C Question about this molecule: Which kind of reaction can this molecule cause? Option A: It can be linked to rare instances of hypersensitivity reactions accompanied by mild liver injury. Option B: It can be associated with the risk of developing allergic reactions in some high-risk patients, such as those with asthma. Option C: It can cause hypersensitivity reactions, some of which are accompanied by liver injury which is typically cholestatic. Option D: It can cause 25-hydroxylation catalyzed by the 25-hydroxylase in the liver and then by other enzymes. " D 9321 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: NN Question about this molecule: Which kind of reaction can this molecule cause? Option A: It can replace inorganic phosphate in the step of glycolysis that produces 1,3-bisphosphoglycerate. Option B: It can induce a rearrangement reaction to 4,4'-benzidine when treated with mineral acids. Option C: It can cause thiophene formation reaction of 1,4-diketones with Lawesson's reagent. Option D: It can condense with 2,4-pentanedione to give the 3,5-dimethylpyrazole. " D 92253 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCN1CCCC[C@H]1C(=O)NC2=C(C=CC=C2C)C Question about this molecule: Which kind of reaction can this molecule cause? Option A: It can cause redox reactions and conjugation reactions. Option B: It can cause allergic reactions. Option C: It can cause allergic reactions, although only rarely. Option D: It can react with thiols as a Michael acceptor. " C 5852 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)([C@H](C(=O)O)N)S Question about this molecule: Which kind of reaction can this molecule cause? Option A: It can cause hypersensitivity reactions, some of which are accompanied by liver injury which is typically cholestatic. Option B: It can be associated with the risk of developing allergic reactions in some high-risk patients, such as those with asthma. Option C: It can be linked to rare instances of hypersensitivity reactions accompanied by mild liver injury. Option D: It can cause allergic reactions, although only rarely. " A 2244 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)OC1=CC=CC=C1C(=O)O Question about this molecule: Which kind of reaction can this molecule cause? Option A: It can cause a reaction that requires acidification with phosphoric acid and heating the reagents under reflux with a boiling water bath for between 40 minutes and an hour. Option B: It can cause the formation of a highly reactive methyl diazonium cation capable of methylating various residues on adenosine and guanine bases leading to DNA lesions and eventual apoptosis. Option C: It can cause the formation of a diradical that will abstract a hydrogen atom from a suitable hydrogen donor to form a ketyl radical. Option D: It can cause oxidation of the iron atoms in hemoglobin from Ferrous Iron (2+) to Ferric Iron (3+), rendering it unable to carry oxygen. " A 3102 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(=O)C2=CC=CC=C2 Question about this molecule: Which kind of reaction can this molecule cause? Option A: It can cause the formation of a diradical that will abstract a hydrogen atom from a suitable hydrogen donor to form a ketyl radical. Option B: It can cause the formation of a highly reactive methyl diazonium cation capable of methylating various residues on adenosine and guanine bases leading to DNA lesions and eventual apoptosis. Option C: It can cause a reaction that requires acidification with phosphoric acid and heating the reagents under reflux with a boiling water bath for between 40 minutes and an hour. Option D: It can cause oxidation of the iron atoms in hemoglobin from Ferrous Iron (2+) to Ferric Iron (3+), rendering it unable to carry oxygen. " A 2771 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F Question about this molecule: Which kind of reaction can this molecule cause? Option A: It can cause the formation of a highly reactive methyl diazonium cation capable of methylating various residues on adenosine and guanine bases leading to DNA lesions and eventual apoptosis. Option B: It can cause chronic inhalation exposure resulting in significant decreases in lung function in workers, an asthma-like reaction characterized by wheezing, dyspnea, and bronchial constriction. Option C: It can cause decarboxylation of phenylpyruvate to give phenylacetate and reduction reaction to give phenyllactate. Option D: It can block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. " D 7847 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC=O Question about this molecule: Which kind of reaction can this molecule cause? Option A: It can cause allergic reactions. Option B: It can cause redox reactions and conjugation reactions. Option C: It can cause allergic reactions, although only rarely. Option D: It can react with thiols as a Michael acceptor. " D 5284466 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Cl-].[Cl-].[Sn+2] Question about this molecule: Which kind of reaction can this molecule cause? Option A: It can be associated with the risk of developing allergic reactions in some high-risk patients, such as those with asthma. Option B: It can reduce technetium-99m, allowing it to form a complex with phosphate-containing moieties. Option C: It can cause hypersensitivity reactions, some of which are accompanied by liver injury which is typically cholestatic. Option D: It can be linked to rare instances of hypersensitivity reactions accompanied by mild liver injury. " B 3386 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F Question about this molecule: Which kind of reaction can this molecule cause? Option A: It can cause decarboxylation of phenylpyruvate to give phenylacetate and reduction reaction to give phenyllactate. Option B: It can block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option C: It can cause chronic inhalation exposure resulting in significant decreases in lung function in workers, an asthma-like reaction characterized by wheezing, dyspnea, and bronchial constriction. Option D: It can cause the formation of a highly reactive methyl diazonium cation capable of methylating various residues on adenosine and guanine bases leading to DNA lesions and eventual apoptosis. " B 5862 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@@H](C(=O)O)N)S Question about this molecule: Which kind of reaction can this molecule cause? Option A: It can cause oxidation of the iron atoms in hemoglobin from Ferrous Iron (2+) to Ferric Iron (3+), rendering it unable to carry oxygen. Option B: It can cause the formation of a highly reactive methyl diazonium cation capable of methylating various residues on adenosine and guanine bases leading to DNA lesions and eventual apoptosis. Option C: It can cause chronic inhalation exposure resulting in significant decreases in lung function in workers, an asthma-like reaction characterized by wheezing, dyspnea, and bronchial constriction. Option D: It can undergo oxidation/reduction (redox) reactions and form cystine when oxidized, which is two this molecule residues joined by a disulfide bond. " D 23978 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Cu] Question about this molecule: Which kind of reaction can this molecule cause? Option A: It can cause redox reactions and conjugation reactions. Option B: It can catalyze the reduction of molecular oxygen (O2) to water (H2O). Option C: It can react with carbon dioxide (CO2) via a reversible reaction to form a carbamic acid. Option D: It can react with thiols as a Michael acceptor. " B 124886 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(=O)N[C@@H](CS)C(=O)NCC(=O)O)[C@@H](C(=O)O)N Question about this molecule: Which kind of reaction can this molecule cause? Option A: It can react with thiols as a Michael acceptor. Option B: It can cause allergic reactions. Option C: It can cause allergic reactions, although only rarely. Option D: It can cause redox reactions and conjugation reactions. " D 234 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O[As](=O)(O)O Question about this molecule: Which kind of reaction can this molecule cause? Option A: It can be linked to rare instances of hypersensitivity reactions accompanied by mild liver injury. Option B: It can cause 25-hydroxylation catalyzed by the 25-hydroxylase in the liver and then by other enzymes. Option C: It can replace inorganic phosphate in the step of glycolysis that produces 1,3-bisphosphoglycerate. Option D: It can cause hypersensitivity reactions, some of which are accompanied by liver injury which is typically cholestatic. " C 277 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(N)O Question about this molecule: Which kind of reaction can this molecule cause? Option A: It can react with thiols as a Michael acceptor. Option B: It can react with carbon dioxide (CO2) via a reversible reaction to form a carbamic acid. Option C: It can cause allergic reactions, although only rarely. Option D: It can cause redox reactions and conjugation reactions. " B 43815 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4 Question about this molecule: Which kind of reaction can this molecule cause? Option A: It can cause decarboxylation of phenylpyruvate to give phenylacetate and reduction reaction to give phenyllactate. Option B: It can block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option C: It can cause chronic inhalation exposure resulting in significant decreases in lung function in workers, an asthma-like reaction characterized by wheezing, dyspnea, and bronchial constriction. Option D: It can cause the formation of a highly reactive methyl diazonium cation capable of methylating various residues on adenosine and guanine bases leading to DNA lesions and eventual apoptosis. " B 8378 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N Question about this molecule: Which kind of reaction can this molecule cause? Option A: It can reduce technetium-99m, allowing it to form a complex with phosphate-containing moieties. Option B: It can be linked to rare instances of hypersensitivity reactions accompanied by mild liver injury. Option C: It can cause hypersensitivity reactions, some of which are accompanied by liver injury which is typically cholestatic. Option D: It can yield neamine and neobiosamine B on hydrolysis. " D 7111 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C2=CC=C(C=C2)N)N Question about this molecule: Which kind of reaction can this molecule cause? Option A: It can replace inorganic phosphate in the step of glycolysis that produces 1,3-bisphosphoglycerate. Option B: It can react with carbon dioxide (CO2) via a reversible reaction to form a carbamic acid. Option C: It can cause thiophene formation reaction of 1,4-diketones with Lawesson's reagent. Option D: It can induce a rearrangement reaction to 4,4'-benzidine when treated with mineral acids. " D 999 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)CC(=O)O Question about this molecule: Which kind of reaction can this molecule cause? Option A: It can block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option B: It can cause chronic inhalation exposure resulting in significant decreases in lung function in workers, an asthma-like reaction characterized by wheezing, dyspnea, and bronchial constriction. Option C: It can cause decarboxylation of phenylpyruvate to give phenylacetate and reduction reaction to give phenyllactate. Option D: It can cause the formation of a highly reactive methyl diazonium cation capable of methylating various residues on adenosine and guanine bases leading to DNA lesions and eventual apoptosis. " C 8255 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=C)C Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It can rupture violently and rocket under prolonged exposure to fire or heat. Option B: It can rupture violently and rocket under prolonged exposure to fire or intense heat. Option C: It may rupture violently and rocket under prolonged exposure to fire or intense heat. Option D: It may rupture violently and rocket under prolonged exposure to fire or heat. " D 280 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)=O Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It may rupture violently and rocket under prolonged exposure to heat or fire. Option B: It may rupture violently and rocket under prolonged exposure to fire or heat. Option C: It can rupture violently and rocket under prolonged exposure to fire or intense heat. Option D: It can rupture violently and rocket under prolonged exposure to fire or heat. " A 516902 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]Cl(=O)=O.[Na+] Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It reacts with strong acids to form salts containing the anilinium (or phenylammonium) ion (C6H5-NH3+) and reacts with acyl halides to form amides. Option B: It is a reactive species capable of forming adducts and complexes in biological systems. The main species at physiological pH is the enolate ion, which is of relative low reactivity. Option C: It may result in fires or explosions when in contact with wood, organic matter, ammonium salts, sulfur, sulfuric acid, various metals, and other chemicals, particularly if any solid materials are finely divided. Option D: It is easily ignited in air, reacts with oxidizing agents, and is very toxic by inhalation. It is also a strong irritant to skin, eyes, and mucous membranes. " C 6569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)C Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It does not react with water. Option B: It is insoluble in water and does not react with larger volumes of water. Option C: The containers may rupture violently and rocket under prolonged exposure to fire or intense heat. Option D: It does not react with water or many common materials. " D 297 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It can rupture violently and rocket under prolonged exposure to fire or intense heat. Option B: The containers may rupture violently and rocket under prolonged exposure to fire or intense heat. Option C: The containers may violently rupture and rocket under prolonged exposure to fire or intense heat. Option D: It may rupture violently and rocket under prolonged exposure to fire or intense heat. " D 2256 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC1=NC(=NC(=N1)Cl)NC(C)C Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It is a colorless, toxic, and highly reactive gas. Option B: It reacts slowly with metals causing mild corrosion. Option C: It is a severe blistering agent, causing third degree chemical burns of the skin. Option D: It is a poor energy source due to the oxidized state of ring carbon. " D 23953 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [SiH4] Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. Option B: It is a reactive species capable of forming adducts and complexes in biological systems. The main species at physiological pH is the enolate ion, which is of relative low reactivity. Option C: It is easily ignited in air, reacts with oxidizing agents, and is very toxic by inhalation. It is also a strong irritant to skin, eyes, and mucous membranes. Option D: It reacts with strong acids to form salts containing the anilinium (or phenylammonium) ion (C6H5-NH3+) and reacts with acyl halides to form amides. " C 7845 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC=C Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: If the polymerization takes place inside a container, the container may rupture violently. Option B: If polymerization occurs in the container, it may violently rupture. Option C: If the polymerization takes place inside a container, it may rupture violently. Option D: If polymerization takes place inside a closed container, the container is subject to violent rupture. " B 145068 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N]=O Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: The containers may violently rupture and rocket under prolonged exposure to fire or intense heat. Option B: Heating the containers may cause them to rupture violently and rocket. Option C: It may rupture violently and rocket under prolonged exposure to fire or intense heat. Option D: The containers may rupture violently and rocket under prolonged exposure to fire or intense heat. " B 10964 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C=O)C=O Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. Option B: It reacts with strong acids to form salts containing the anilinium (or phenylammonium) ion (C6H5-NH3+) and reacts with acyl halides to form amides. Option C: It is a reactive species capable of forming adducts and complexes in biological systems. The main species at physiological pH is the enolate ion, which is of relative low reactivity. Option D: It is easily ignited in air, reacts with oxidizing agents, and is very toxic by inhalation. It is also a strong irritant to skin, eyes, and mucous membranes. " C 6658 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=C)C(=O)OC Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It can be a neutron source and has been used as a neutron trigger or initiator for nuclear weapons when mixed or alloyed with beryllium. Option B: It is a reactive species capable of forming adducts and complexes in biological systems. The main species at physiological pH is the enolate ion, which is of relative low reactivity. Option C: It is easily ignited in air, reacts with oxidizing agents, and is very toxic by inhalation. It is also a strong irritant to skin, eyes, and mucous membranes. Option D: It may polymerize exothermically if heated or contaminated with strong acid or base. " D 17358 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: FS(F)(F)(F)(F)F Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It may rupture violently and rocket under prolonged exposure to fire or intense heat. Option B: It can rupture violently and rocket under prolonged exposure to fire or intense heat. Option C: It may rupture violently and rocket under prolonged exposure to fire or heat. Option D: It can rupture violently and rocket under prolonged exposure to fire or heat. " C 10903 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It can rupture violently and rocket under prolonged exposure to fire or intense heat. Option B: It may rupture violently and rocket under prolonged exposure to fire or intense heat. Option C: It can rupture violently and rocket under prolonged exposure to fire or heat. Option D: It may rupture violently and rocket under prolonged exposure to fire or heat. " D 674 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: The containers may rupture violently and rocket under prolonged exposure to fire or intense heat. Option B: It can rupture violently and rocket under prolonged exposure to fire or intense heat. Option C: It may rupture violently and rocket under prolonged exposure to fire or intense heat. Option D: The containers may violently rupture and rocket under prolonged exposure to fire or intense heat. " C 11487 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)NC2=CC=CC=C2 Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It is insoluble in water and does not react with larger volumes of water. Option B: It does not react with water or many common materials. Option C: It forms a water-soluble salt when reacted with strong acids. Option D: It does not react with water. " C 6579 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC(=O)N Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: The containers may violently rupture and rocket under prolonged exposure to fire or intense heat. Option B: The containers may rupture violently and rocket under prolonged exposure to fire or intense heat. Option C: It can react violently when melted. Option D: Heating the containers may cause them to rupture violently and rocket. " C 4650 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=O)C=CC1=O Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: The containers may rupture violently and rocket under prolonged exposure to fire or intense heat. Option B: It reacts slowly with metals causing mild corrosion. Option C: It reacts with hydrogen peroxide to produce a fiery blast of steam. Option D: The containers may violently rupture and rocket under prolonged exposure to fire or intense heat. " C 6366 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=C(Cl)Cl Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: If polymerization takes place inside a closed container, the container is subject to violent rupture. Option B: If the polymerization takes place inside a container, it may rupture violently. Option C: If polymerization occurs in the container, it may violently rupture. Option D: If the polymerization takes place inside a container, the container may rupture violently. " D 68617 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN[C@H]1CC[C@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. Option B: It can block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. Option C: It reacts with strong acids to form salts containing the anilinium (or phenylammonium) ion (C6H5-NH3+) and reacts with acyl halides to form amides. Option D: It is easily ignited in air, reacts with oxidizing agents, and is very toxic by inhalation. It is also a strong irritant to skin, eyes, and mucous membranes. " A 6212 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)(Cl)Cl Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: Reacts with water Option B: Relatively unreactive Option C: Non-reactive with copper and lead Option D: Reacts with beta-aspartyl-AMP " B 6407 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)C(Cl)(Cl)Cl Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: Reacts with water Option B: Relatively unreactive Option C: Reacts with beta-aspartyl-AMP Option D: Non-reactive with copper and lead " A 853433 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C=C/C1=CC(=C(C=C1)O)OC Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: The containers may rupture violently and rocket under prolonged exposure to fire or intense heat. Option B: It may polymerize exothermically if heated or contaminated with strong acid or base. Option C: Allergic reactivity Option D: It may rupture violently and rocket under prolonged exposure to fire or intense heat. " C 757 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)O)O Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: Reacts with the upper layer of the epidermis Option B: Relatively unreactive Option C: Reacts with beta-aspartyl-AMP Option D: Reacts with water " A 6267 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@@H](C(=O)O)N)C(=O)N Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: Reacts with water Option B: Non-reactive with copper and lead Option C: Relatively unreactive Option D: Reacts with beta-aspartyl-AMP " D 7434 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C=C1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: Heating the containers may cause them to rupture violently and rocket. Option B: High explosive Option C: It can react violently when melted. Option D: It is a useful explosive material with convenient handling properties. " B 31236 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)OCCO Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: Heating the containers may cause them to rupture violently and rocket. Option B: The containers may violently rupture and rocket under prolonged exposure to fire or intense heat. Option C: The containers may rupture violently and rocket under prolonged exposure to fire or intense heat. Option D: Non-reactive with copper and lead " D 4499 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It is a useful explosive material with convenient handling properties. Option B: It can react violently when melted. Option C: High explosive Option D: Prevents calcium-dependent smooth muscle contraction " D 160556 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCN[C@@H](CCC(=O)O)C(=O)O)C[C@@H](C(=O)O)N Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It reacts with strong acids to form salts containing the anilinium (or phenylammonium) ion (C6H5-NH3+) and reacts with acyl halides to form amides. Option B: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. Option C: It can block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. Option D: Strict substrate specificity for L-lysine, 2-oxoglutarate and NADPH " D 2771 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It can block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. Option B: It reacts with strong acids to form salts containing the anilinium (or phenylammonium) ion (C6H5-NH3+) and reacts with acyl halides to form amides. Option C: Blocks serotonin reuptake and increases serotonin stimulation Option D: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. " C 1752 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCC1=CC=C(C=C1)O Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: The containers may rupture violently and rocket under prolonged exposure to fire or intense heat. Option B: Reactive with atmospheric radicals and/or is photoactive Option C: It can rupture violently and rocket under prolonged exposure to fire or intense heat. Option D: It may rupture violently and rocket under prolonged exposure to fire or intense heat. " B 7847 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC=O Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: Non-reactive with copper and lead Option B: Reacts with beta-aspartyl-AMP Option C: Reacts with water Option D: Electrophilic and reactive " D 977 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=O Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: The containers may violently rupture and rocket under prolonged exposure to fire or intense heat. Option B: The containers may rupture violently and rocket under prolonged exposure to fire or intense heat. Option C: It can rupture violently and rocket under prolonged exposure to fire or intense heat. Option D: It may rupture violently and rocket under prolonged exposure to fire or intense heat. " C 712 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=O Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It is a severe blistering agent, causing third degree chemical burns of the skin. Option B: It is a colorless, toxic, and highly reactive gas. Option C: It reacts slowly with metals causing mild corrosion. Option D: It is a highly reactive aldehyde gas. " D 23969 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [AsH3] Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It can rupture violently and rocket under prolonged exposure to fire or intense heat. Option B: It may rupture violently and rocket under prolonged exposure to fire or intense heat. Option C: It may rupture violently and rocket under prolonged exposure to fire or heat. Option D: It can rupture violently and rocket under prolonged exposure to fire or heat. " D 3386 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It can block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. Option B: It reacts with strong acids to form salts containing the anilinium (or phenylammonium) ion (C6H5-NH3+) and reacts with acyl halides to form amides. Option C: It is easily ignited in air, reacts with oxidizing agents, and is very toxic by inhalation. It is also a strong irritant to skin, eyes, and mucous membranes. Option D: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. " A 6360 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It can rupture violently and rocket under prolonged exposure to fire or intense heat. Option B: It may rupture violently and rocket under prolonged exposure to fire or intense heat. Option C: The containers may rupture violently and rocket under prolonged exposure to fire or intense heat. Option D: The containers may violently rupture and rocket under prolonged exposure to fire or intense heat. " A 784 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OO Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It can rupture violently and rocket under prolonged exposure to fire or heat. Option B: It can violently rupture due to decomposition under prolonged exposure to fire or heat. Option C: It may rupture violently and rocket under prolonged exposure to fire or heat. Option D: It can rupture violently and rocket under prolonged exposure to fire or intense heat. " B 5862 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@@H](C(=O)O)N)S Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It can undergo autoxidations and metal-catalyzed and enzymatic oxidations in man to produce reactive oxygen species. Option B: It reacts slowly with metals causing mild corrosion. Option C: It can undergo redox reactions due to the sulphydryl group it contains. Option D: It is a poor energy source due to the oxidized state of ring carbon. " C 7843 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: The containers may rupture violently and rocket under prolonged exposure to fire or intense heat. Option B: It can rupture violently and rocket under prolonged exposure to fire or intense heat. Option C: The containers may violently rupture and rocket under prolonged exposure to fire or intense heat. Option D: It may rupture violently and rocket under prolonged exposure to fire or intense heat. " B 4093 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=C)C(=O)O Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: If the polymerization takes place inside a container, it may rupture violently. Option B: If polymerization takes place inside a closed container, the container is subject to violent rupture. Option C: If the polymerization takes place inside a container, the container may rupture violently. Option D: If polymerization occurs in the container, it may violently rupture. " A 24489 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]S(=O)S(=O)[O-].[Na+].[Na+] Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It may rupture violently and rocket under prolonged exposure to fire or heat. Option B: It can violently rupture due to decomposition under prolonged exposure to fire or heat. Option C: It spontaneously heats on contact with air and moisture. Option D: It can rupture violently and rocket under prolonged exposure to fire or heat. " C 444266 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=C\\C(=O)O)\\C(=O)O Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It reacts with strong acids to form salts containing the anilinium (or phenylammonium) ion (C6H5-NH3+) and reacts with acyl halides to form amides. Option B: It is easily ignited in air, reacts with oxidizing agents, and is very toxic by inhalation. It is also a strong irritant to skin, eyes, and mucous membranes. Option C: It can be a neutron source and has been used as a neutron trigger or initiator for nuclear weapons when mixed or alloyed with beryllium. Option D: It reacts with thionyl chloride or phosphorus pentachloride to give the this molecule chloride. " D 996 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)O Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It is insoluble in water and does not react with larger volumes of water. Option B: The containers may rupture violently and rocket under prolonged exposure to fire or intense heat. Option C: It does not react with water or many common materials. Option D: It does not react with water. " D 935 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Ni] Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It is insoluble in water and does not react with larger volumes of water. Option B: It does not react with water. Option C: It does not react with water or many common materials. Option D: The containers may rupture violently and rocket under prolonged exposure to fire or intense heat. " A 5362420 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C2=CC3=NC(=CC4=C(C(=C(N4)C=C5[C@@]6([C@@H](C(=CC=C6C(=N5)C=C1N2)C(=O)OC)C(=O)OC)C)C)CCC(=O)OC)C(=C3C)CCC(=O)O)C=C Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It is easily ignited in air, reacts with oxidizing agents, and is very toxic by inhalation. It is also a strong irritant to skin, eyes, and mucous membranes. Option B: It reacts with strong acids to form salts containing the anilinium (or phenylammonium) ion (C6H5-NH3+) and reacts with acyl halides to form amides. Option C: It produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals when stimulated by nonthermal red light with a wavelength of 693 nm in the presence of oxygen. Option D: It is a reactive species capable of forming adducts and complexes in biological systems. The main species at physiological pH is the enolate ion, which is of relative low reactivity. " C 7242 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1N Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It is a colorless, toxic, and highly reactive gas. Option B: It is a highly reactive aldehyde gas. Option C: It is a severe blistering agent, causing third degree chemical burns of the skin. Option D: It reacts with formaldehyde to form Troger's base. " D 8376 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It can react violently when melted. Option B: High explosive Option C: Heating the containers may cause them to rupture violently and rocket. Option D: It is a useful explosive material with convenient handling properties. " D 234 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O[As](=O)(O)O Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: High explosive Option B: It is a useful explosive material with convenient handling properties. Option C: It is arsenic acid. Option D: Contact with strong sulfuric acid can cause fires or explosions. " C 104770 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]Cl(=O)=O Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: Contact with strong sulfuric acid can cause fires or explosions. Option B: It reacts slowly with metals causing mild corrosion. Option C: It can react with carbon dioxide (CO2) via a reversible reaction to form a carbamic acid. Option D: The containers may rupture violently and rocket under prolonged exposure to fire or intense heat. " A 6849 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC=C2[N+](=O)[O-] Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It can react with carbon dioxide (CO2) via a reversible reaction to form a carbamic acid. Option B: It can rupture violently and rocket under prolonged exposure to fire or heat. Option C: It can react with ozone and form reactive electrophiles that bind covalently to specific proteins. Option D: It can violently rupture due to decomposition under prolonged exposure to fire or heat. " C 6337 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCl Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It can rupture violently and rocket under prolonged exposure to fire or heat. Option B: It can rupture violently and rocket under prolonged exposure to fire or intense heat. Option C: It may rupture violently and rocket under prolonged exposure to fire or intense heat. Option D: It may rupture violently and rocket under prolonged exposure to fire or heat. " A 277 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(N)O Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: Contact with strong sulfuric acid can cause fires or explosions. Option B: The containers may rupture violently and rocket under prolonged exposure to fire or intense heat. Option C: It can react with carbon dioxide (CO2) via a reversible reaction to form a carbamic acid. Option D: It reacts slowly with metals causing mild corrosion. " C 403 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1N)O Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It can be a neutron source and has been used as a neutron trigger or initiator for nuclear weapons when mixed or alloyed with beryllium. Option B: It is easily ignited in air, reacts with oxidizing agents, and is very toxic by inhalation. It is also a strong irritant to skin, eyes, and mucous membranes. Option C: It can undergo autoxidations and metal-catalyzed and enzymatic oxidations in man to produce reactive oxygen species. Option D: It is a reactive species capable of forming adducts and complexes in biological systems. The main species at physiological pH is the enolate ion, which is of relative low reactivity. " C 6328544 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [210Po] Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It is a reactive species capable of forming adducts and complexes in biological systems. The main species at physiological pH is the enolate ion, which is of relative low reactivity. Option B: It can be a neutron source and has been used as a neutron trigger or initiator for nuclear weapons when mixed or alloyed with beryllium. Option C: It is easily ignited in air, reacts with oxidizing agents, and is very toxic by inhalation. It is also a strong irritant to skin, eyes, and mucous membranes. Option D: It reacts with strong acids to form salts containing the anilinium (or phenylammonium) ion (C6H5-NH3+) and reacts with acyl halides to form amides. " B 6327 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCl Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: The containers may violently rupture and rocket under prolonged exposure to fire or intense heat. Option B: The containers may rupture violently and rocket under prolonged exposure to fire or intense heat. Option C: It may rupture violently and rocket under prolonged exposure to fire or intense heat. Option D: It can rupture violently and rocket under prolonged exposure to fire or intense heat. " D 43815 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4 Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It can block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. Option B: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. Option C: It is easily ignited in air, reacts with oxidizing agents, and is very toxic by inhalation. It is also a strong irritant to skin, eyes, and mucous membranes. Option D: It reacts with strong acids to form salts containing the anilinium (or phenylammonium) ion (C6H5-NH3+) and reacts with acyl halides to form amides. " B 6115 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)N Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It reacts with strong acids to form salts containing the anilinium (or phenylammonium) ion (C6H5-NH3+) and reacts with acyl halides to form amides. Option B: It is easily ignited in air, reacts with oxidizing agents, and is very toxic by inhalation. It is also a strong irritant to skin, eyes, and mucous membranes. Option C: It can block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. Option D: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. " A 146570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCC[C@@]1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It reacts with strong acids to form salts containing the anilinium (or phenylammonium) ion (C6H5-NH3+) and reacts with acyl halides to form amides. Option B: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. Option C: It can block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use. Option D: It is easily ignited in air, reacts with oxidizing agents, and is very toxic by inhalation. It is also a strong irritant to skin, eyes, and mucous membranes. " B 7835 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C(O1)CCl Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: If polymerization occurs in the container, it may violently rupture. Option B: If the polymerization takes place inside a container, the container may rupture violently. Option C: If polymerization takes place inside a closed container, the container is subject to violent rupture. Option D: If the polymerization takes place inside a container, it may rupture violently. " C 12695 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(F)(F)F)C(F)(F)F Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It reacts slowly with metals causing mild corrosion. Option B: It is a colorless, toxic, and highly reactive gas. Option C: The containers may rupture violently and rocket under prolonged exposure to fire or intense heat. Option D: It is a severe blistering agent, causing third degree chemical burns of the skin. " B 281 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C-]#[O+] Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: The containers may rupture violently and rocket under prolonged exposure to fire or intense heat. Option B: The containers may violently rupture and rocket under prolonged exposure to fire or intense heat. Option C: It may rupture violently and rocket under prolonged exposure to fire or intense heat. Option D: It can rupture violently and rocket under prolonged exposure to fire or intense heat. " B 11638 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CF Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It reacts slowly with metals causing mild corrosion. Option B: The containers may violently rupture and rocket under prolonged exposure to fire or intense heat. Option C: It burns with evolution of hydrogen fluoride. Option D: It reacts with hydrogen peroxide to produce a fiery blast of steam. " C 6259 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(=O)CBr Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It reacts slowly with metals causing mild corrosion. Option B: Heating the containers may cause them to rupture violently and rocket. Option C: The containers may rupture violently and rocket under prolonged exposure to fire or intense heat. Option D: The containers may violently rupture and rocket under prolonged exposure to fire or intense heat. " A 9033 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN1 Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: The containers may rupture violently and rocket under prolonged exposure to fire or intense heat. Option B: It reacts slowly with metals causing mild corrosion. Option C: It is a severe blistering agent, causing third degree chemical burns of the skin. Option D: It is a colorless, toxic, and highly reactive gas. " C 783 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [HH] Question about this molecule: Which kind of reactivity does this molecule have/exhibit? Option A: It may rupture violently and rocket under prolonged exposure to fire or intense heat. Option B: It can rupture violently and rocket under prolonged exposure to fire or intense heat. Option C: The containers may rupture violently and rocket under prolonged exposure to fire or intense heat. Option D: The containers may violently rupture and rocket under prolonged exposure to fire or intense heat. " C 9294 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]([C@@H](C1=CC=CC=C1)O)NC Question about this molecule: Which kind of receptor activity does this molecule have/exhibit? Option A: It is an alpha adrenergic receptor agonist (primarily alpha-2). Option B: It is a non-selective α- and β-adrenergic receptor agonist. Option C: It is an alpha- and beta-adrenergic receptor agonist. Option D: It acts as a weak TrkB receptor agonist. " C 4095 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2 Question about this molecule: Which kind of receptor activity does this molecule have/exhibit? Option A: It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT1A receptors and as an antagonist at serotonin 5-HT2A receptors. Option B: It acts as an agonist of κ- and σ-opioid receptors, as an antagonist of the N-methyl-D-aspartate (NMDA) receptor, and as an inhibitor of serotonin and norepinephrine uptake. Option C: It has partial agonist activity at the D2 receptor, partial agonist activity at the 5-HT1A receptor, and antagonist profile at the 5-HT2A receptor. Option D: It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. " B 5284603 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)OC)O4)O Question about this molecule: Which kind of receptor activity does this molecule have/exhibit? Option A: It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT1A receptors and as an antagonist at serotonin 5-HT2A receptors. Option B: It has partial agonist activity at the D2 receptor, partial agonist activity at the 5-HT1A receptor, and antagonist profile at the 5-HT2A receptor. Option C: It acts as a weak agonist at mu, kappa, and delta opioid receptors within the central nervous system (CNS). Option D: It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. " C 2230 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CCC=C(C1)C(=O)OC Question about this molecule: Which kind of receptor activity does this molecule have/exhibit? Option A: It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. Option B: It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT1A receptors and as an antagonist at serotonin 5-HT2A receptors. Option C: It acts as a weak agonist at mu, kappa, and delta opioid receptors within the central nervous system (CNS). Option D: It is an agonist at both muscarinic and nicotinic acetylcholine receptors. " D 644019 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC1=CC(=C(C(=C1)O)[C@@H]2C=C(CC[C@H]2C(=C)C)C)O Question about this molecule: Which kind of receptor activity does this molecule have/exhibit? Option A: It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT1A receptors and as an antagonist at serotonin 5-HT2A receptors. Option B: It causes neuronal membrane hyperpolarization and a resultant inhibition of neurotransmitter release by activating the GABA-B receptor. Option C: It activates 5-HT1A/2A/3A serotonergic and TRPV1–2 vanilloid receptors, antagonizes alpha-1 adrenergic and µ-opioid receptors, inhibits synaptosomal uptake of noradrenaline, dopamine, serotonin and gamma-aminobutyric acid (GABA), and cellular uptake of anandamide, acts on mitochondria Ca2+ stores, blocks low-voltage-activated (T-type) Ca2+ channels, stimulates activity of the inhibitory glycine-receptor, and inhibits activity of fatty amide hydrolase (FAAH). Option D: It has partial agonist activity at the D2 receptor, partial agonist activity at the 5-HT1A receptor, and antagonist profile at the 5-HT2A receptor. " C 54746 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@H]2[C@@H](CC3=CNC4=CC=CC2=C34)N(C1)CC=C Question about this molecule: Which kind of receptor activity does this molecule have/exhibit? Option A: It causes neuronal membrane hyperpolarization and a resultant inhibition of neurotransmitter release by activating the GABA-B receptor. Option B: It acts as a weak agonist at mu, kappa, and delta opioid receptors within the central nervous system (CNS). Option C: It exerts greater blocking activity on myocardial beta1-receptors than on beta2 ones in the lung. Option D: It blocks phosphorylation of p42/p44 MAPK and decreases MAPK/ERK kinase phosphorylation. " D 443879 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=C(C=C1)O)[C@H](CCN(C(C)C)C(C)C)C2=CC=CC=C2 Question about this molecule: Which kind of receptor activity does this molecule have/exhibit? Option A: It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. Option B: It acts as a weak agonist at mu, kappa, and delta opioid receptors within the central nervous system (CNS). Option C: It is an agonist at both muscarinic and nicotinic acetylcholine receptors. Option D: It acts on M2 and M3 subtypes of muscarinic receptors. " D 2249 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(COC1=CC=C(C=C1)CC(=O)N)O Question about this molecule: Which kind of receptor activity does this molecule have/exhibit? Option A: It exerts greater blocking activity on myocardial beta1-receptors than on beta2 ones in the lung. Option B: It acts as a weak agonist at mu, kappa, and delta opioid receptors within the central nervous system (CNS). Option C: It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT1A receptors and as an antagonist at serotonin 5-HT2A receptors. Option D: It causes neuronal membrane hyperpolarization and a resultant inhibition of neurotransmitter release by activating the GABA-B receptor. " A 11154555 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C(=O)NC1CCC(CC1)CCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl Question about this molecule: Which kind of receptor activity does this molecule have/exhibit? Option A: It has partial agonist activity at the D2 receptor, partial agonist activity at the 5-HT1A receptor, and antagonist profile at the 5-HT2A receptor. Option B: It acts as an agonist of κ- and σ-opioid receptors, as an antagonist of the N-methyl-D-aspartate (NMDA) receptor, and as an inhibitor of serotonin and norepinephrine uptake. Option C: It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. Option D: It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT1A receptors and as an antagonist at serotonin 5-HT2A receptors. " D 5281612 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O Question about this molecule: Which kind of receptor activity does this molecule have/exhibit? Option A: It is a highly potent, competitive, preferential dopamine D3 receptor antagonist. Option B: It acts as a weak TrkB receptor agonist. Option C: It displays potent and selective 5-HT1B/1D receptor antagonist activity. Option D: It is a potent and selective 5-HT1A receptor partial agonist. " B 838 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNCC(C1=CC(=C(C=C1)O)O)O Question about this molecule: Which kind of receptor activity does this molecule have/exhibit? Option A: It is a non-selective α- and β-adrenergic receptor agonist. Option B: It is an alpha- and beta-adrenergic receptor agonist. Option C: It acts as a weak TrkB receptor agonist. Option D: It is an alpha adrenergic receptor agonist (primarily alpha-2). " A 3821 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC1(CCCCC1=O)C2=CC=CC=C2Cl Question about this molecule: Which kind of receptor activity does this molecule have/exhibit? Option A: It is an NMDA receptor antagonist. Option B: It is a highly potent, competitive, preferential dopamine D3 receptor antagonist. Option C: It is a noncompetitive AMPA glutamate receptor antagonist. Option D: It displays potent and selective 5-HT1B/1D receptor antagonist activity. " A 119 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(=O)O)CN Question about this molecule: Which kind of receptor activity does this molecule have/exhibit? Option A: It causes neuronal membrane hyperpolarization and a resultant inhibition of neurotransmitter release by activating the GABA-B receptor. Option B: It acts as a weak agonist at mu, kappa, and delta opioid receptors within the central nervous system (CNS). Option C: It exerts greater blocking activity on myocardial beta1-receptors than on beta2 ones in the lung. Option D: It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT1A receptors and as an antagonist at serotonin 5-HT2A receptors. " A 5610 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CCN)O Question about this molecule: Which kind of receptor antagonist is this molecule? Option A: It acts as a neurotransmitter via a G protein-coupled receptor with high affinity for this molecule called TA1. Option B: It affects mu-, kappa-, and delta-opioid receptors. Option C: It increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option D: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. " A 68617 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN[C@H]1CC[C@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl Question about this molecule: Which kind of receptor antagonist is this molecule? Option A: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option B: It acts as a neurotransmitter via a G protein-coupled receptor with high affinity for this molecule called TA1. Option C: It increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option D: It affects mu-, kappa-, and delta-opioid receptors. " C 3658 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(CCN1CCOCCO)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl Question about this molecule: Which kind of receptor antagonist is this molecule? Option A: It is a histamine H1-receptor antagonist. Option B: It stimulates dopamine D2 receptors. Option C: It shows weak antagonism at the dopamine D2 receptor. Option D: It binds to the histamine H1 receptor. " A 5487427 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+]1([C@@H]2CC(C[C@H]1[C@H]3[C@@H]2O3)OC(=O)C(C4=CC=CS4)(C5=CC=CS5)O)C Question about this molecule: Which kind of receptor antagonist is this molecule? Option A: It acts mainly on M3 muscarinic receptors. Option B: It affects mu-, kappa-, and delta-opioid receptors. Option C: It blocks M3 muscarinic receptors. Option D: It increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. " A 5280961 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O Question about this molecule: Which kind of receptor antagonist is this molecule? Option A: It activates peroxisome proliferator-activated receptors. Option B: It blocks M3 muscarinic receptors. Option C: It increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option D: It acts mainly on M3 muscarinic receptors. " A 2771 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F Question about this molecule: Which kind of receptor antagonist is this molecule? Option A: It affects mu-, kappa-, and delta-opioid receptors. Option B: It acts as a neurotransmitter via a G protein-coupled receptor with high affinity for this molecule called TA1. Option C: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option D: It increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. " D 3386 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F Question about this molecule: Which kind of receptor antagonist is this molecule? Option A: It affects mu-, kappa-, and delta-opioid receptors. Option B: It acts as a neurotransmitter via a G protein-coupled receptor with high affinity for this molecule called TA1. Option C: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option D: It increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. " D 54746 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@H]2[C@@H](CC3=CNC4=CC=CC2=C34)N(C1)CC=C Question about this molecule: Which kind of receptor antagonist is this molecule? Option A: It stimulates dopamine D2 receptors. Option B: It is an oral dopamine receptor agonist. Option C: It shows weak antagonism at the dopamine D2 receptor. Option D: It acts on dopamine receptors. " A 1993 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C[N+](C)(C)C)OC(=O)C Question about this molecule: Which kind of receptor antagonist is this molecule? Option A: It increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option B: It affects mu-, kappa-, and delta-opioid receptors. Option C: It acts mainly on M3 muscarinic receptors. Option D: It blocks M3 muscarinic receptors. " D 11504295 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(CC1=CC=C(C=C1)OC)NC[C@@H](C2=C3C(=CC(=C2)O)NC(=O)CO3)O Question about this molecule: Which kind of receptor antagonist is this molecule? Option A: It primarily affects OP3 receptors. Option B: It blocks Beta2-adrenergic receptors. Option C: It affects beta2 receptors. Option D: It acts at serotonin receptors. " B 2249 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(COC1=CC=C(C=C1)CC(=O)N)O Question about this molecule: Which kind of receptor antagonist is this molecule? Option A: It primarily affects OP3 receptors. Option B: It affects beta2 receptors. Option C: It activates peroxisome proliferator-activated receptors. Option D: It primarily affects opiate receptors in the intestine. " B 5284569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3C(=O)CC4 Question about this molecule: Which kind of receptor antagonist is this molecule? Option A: It acts mainly on M3 muscarinic receptors. Option B: It primarily affects OP3 receptors. Option C: It primarily affects opiate receptors in the intestine. Option D: It blocks M3 muscarinic receptors. " B 41693 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCC3=CC=CS3)COC Question about this molecule: Which kind of receptor antagonist is this molecule? Option A: It shows weak antagonism at the dopamine D2 receptor. Option B: It stimulates dopamine D2 receptors. Option C: It acts as an OP1 receptor agonist. Option D: It is an oral dopamine receptor agonist. " C 3955 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4 Question about this molecule: Which kind of receptor antagonist is this molecule? Option A: It primarily affects OP3 receptors. Option B: It primarily affects opiate receptors in the intestine. Option C: It blocks M3 muscarinic receptors. Option D: It acts mainly on M3 muscarinic receptors. " B 43815 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4 Question about this molecule: Which kind of receptor antagonist is this molecule? Option A: It affects mu-, kappa-, and delta-opioid receptors. Option B: It acts as a neurotransmitter via a G protein-coupled receptor with high affinity for this molecule called TA1. Option C: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option D: It increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. " C 146570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCC[C@@]1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F Question about this molecule: Which kind of receptor antagonist is this molecule? Option A: It increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option B: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option C: It acts as a neurotransmitter via a G protein-coupled receptor with high affinity for this molecule called TA1. Option D: It affects mu-, kappa-, and delta-opioid receptors. " B 681 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1CCN)O)O Question about this molecule: Which kind of receptor antagonist is this molecule? Option A: It shows weak antagonism at the dopamine D2 receptor. Option B: It stimulates dopamine D2 receptors. Option C: It acts on dopamine receptors. Option D: It is an oral dopamine receptor agonist. " C 176870 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC Question about this molecule: Which kind of receptor antagonist is this molecule? Option A: It increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option B: It binds to the epidermal growth factor receptor (EGFR) tyrosine kinase. Option C: It acts as a neurotransmitter via a G protein-coupled receptor with high affinity for this molecule called TA1. Option D: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. " B 5311071 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]\\1CC[C@@H](C/C1=C\\C=C\\2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)/C=C/[C@H](C)C(C)C)C)O Question about this molecule: Which kind of receptor antagonist is this molecule? Option A: It primarily affects opiate receptors in the intestine. Option B: It stimulates the expression of proteins involved in transporting calcium from the lumen of the intestine. Option C: It increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option D: It acts mainly on M3 muscarinic receptors. " B 47811 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN1C[C@@H](C[C@H]2[C@H]1CC3=CNC4=CC=CC2=C34)CSC Question about this molecule: Which kind of receptor antagonist is this molecule? Option A: It acts on dopamine receptors. Option B: It is an oral dopamine receptor agonist. Option C: It shows weak antagonism at the dopamine D2 receptor. Option D: It stimulates dopamine D2 receptors. " B 105089 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC[C@@H](C(=O)O)N Question about this molecule: Which kind of receptor antagonist is this molecule? Option A: It is an oral dopamine receptor agonist. Option B: It acts at serotonin receptors. Option C: It acts on dopamine receptors. Option D: It activates the metabotropic glutamate receptor 5. " D 3845 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=O)C=C(N2)C(=O)O Question about this molecule: Which kind of receptor antagonist is this molecule? Option A: It is an endogenous N-methyl-D-aspartate (NMDA) receptor antagonist. Option B: It is a D1 and D2 receptor antagonist. Option C: It is an NMDA receptor antagonist. Option D: It is a neurokinin 1 receptor antagonist. " A 38853 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)O)N Question about this molecule: Which kind of reduction can this molecule cause? Option A: It can reduce both supine and standing blood pressure. Option B: It can reduce estrogen levels by 98 percent while raising testosterone levels. Option C: It can reduce abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. Option D: It can cause hypoglycemia and require consistent food intake to decrease this risk. " A 946 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: N(=O)[O-] Question about this molecule: Which kind of reduction can this molecule cause? Option A: It can reduce abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. Option B: It can be reduced to nitric oxide or ammonia by many species of bacteria. Option C: It can cause hypoglycemia and require consistent food intake to decrease this risk. Option D: It can reduce estrogen levels by 98 percent while raising testosterone levels. " B 20058 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=CC(=O)NC2=O)OC(=O)C)OC(=O)C Question about this molecule: Which kind of reduction can this molecule cause? Option A: It can reduce morbidity of osteolytic bone metastases by inhibiting tumor-induced bone resorption. Option B: It can reduce toxicity and cell-death associated with two cytotoxic intermediates: 5-fluoro-2'-deoxyuridine-5'-monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). Option C: It can reduce the risk of ototoxicity associated with [cisplatin]. Option D: It can reduce abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. " B 3305 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(O)(P(=O)(O)O)P(=O)(O)O Question about this molecule: Which kind of reduction can this molecule cause? Option A: It can reduce abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. Option B: It can reduce morbidity of osteolytic bone metastases by inhibiting tumor-induced bone resorption. Option C: It can reduce estrogen levels by 98 percent while raising testosterone levels. Option D: It can reduce the risk of ototoxicity associated with [cisplatin]. " B 2727 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)Cl Question about this molecule: Which kind of reduction can this molecule cause? Option A: It can cause hypoglycemia and require consistent food intake to decrease this risk. Option B: It can reduce estrogen levels by 98 percent while raising testosterone levels. Option C: It can reduce abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. Option D: It can reduce the risk of ototoxicity associated with [cisplatin]. " A 445354 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/CO)/C)/C Question about this molecule: Which kind of reduction can this molecule cause? Option A: It can be reversibly reduced to produce retinol or it can be irreversibly oxidized to produce retinoic acid. Option B: It can reduce estrogen levels by 98 percent while raising testosterone levels. Option C: It can reduce the risk of ototoxicity associated with [cisplatin]. Option D: It can cause hypoglycemia and require consistent food intake to decrease this risk. " A 5505 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C Question about this molecule: Which kind of reduction can this molecule cause? Option A: It can reduce the risk of ototoxicity associated with [cisplatin]. Option B: It can cause hypoglycemia and require consistent food intake to decrease this risk. Option C: It can reduce abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. Option D: It can reduce estrogen levels by 98 percent while raising testosterone levels. " B 23978 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Cu] Question about this molecule: Which kind of reduction can this molecule cause? Option A: It can be reversibly reduced to produce retinol or it can be irreversibly oxidized to produce retinoic acid. Option B: It can catalyze the conversion of superoxide radicals (free radicals or ROS) to hydrogen peroxide, which can subsequently be reduced to water by other antioxidant enzymes. Option C: It can be reduced to nitric oxide or ammonia by many species of bacteria. Option D: It can cause hypoglycemia and require consistent food intake to decrease this risk. " B 5282452 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC1C2=NC3=CC=CC=C3C(=C2/C=C/[C@H](C[C@H](CC(=O)O)O)O)C4=CC=C(C=C4)F Question about this molecule: Which kind of reduction can this molecule cause? Option A: It can reduce abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. Option B: It can reduce morbidity of osteolytic bone metastases by inhibiting tumor-induced bone resorption. Option C: It can reduce the risk of ototoxicity associated with [cisplatin]. Option D: It can reduce estrogen levels by 98 percent while raising testosterone levels. " A 24478 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OS(=O)(=S)O Question about this molecule: Which kind of reduction can this molecule cause? Option A: It can reduce abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. Option B: It can reduce estrogen levels by 98 percent while raising testosterone levels. Option C: It can reduce the risk of ototoxicity associated with [cisplatin]. Option D: It can cause hypoglycemia and require consistent food intake to decrease this risk. " C 3100 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2 Question about this molecule: Which kind of reduction can this molecule cause? Option A: It can reduce estrogen levels by 98 percent while raising testosterone levels. Option B: It can reduce both supine and standing blood pressure. Option C: It can cause hypoglycemia and require consistent food intake to decrease this risk. Option D: It does not reduce to d-methamphetamine. " D 25154714 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[C@@H](C(=O)N1CCC[C@H]1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)[C@@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)OC)NC(=O)OC Question about this molecule: What is the right information about this molecule's resistance? Option A: Treatment with first-generation EGFR-TKIs has been associated with the development of resistance through activating mutations in the EGFR gene. Option B: The most common critical NS5A amino acid substitutions that led to reduced susceptibility to this molecule therapy occurred at position Q30 (Q30H/K/R) and M28 in genotype 1a patients and Y93H in genotype 3 patients. Option C: The barrier for development of resistance to NS3/4A inhibitors is lower than that of NS5B inhibitors. Option D: It has a significantly higher barrier to resistance than the first generation NS5A inhibitors, such as [DB09027] and [DB09102]. " B 6451164 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)/C=C/C#N Question about this molecule: What is the right information about this molecule's resistance? Option A: It has a very high potency and reduces the chance of resistance compared to other NNRTI's. Option B: It has a significantly higher barrier to resistance than the first generation NS5A inhibitors, such as [DB09027] and [DB09102]. Option C: The barrier for development of resistance to NS3/4A inhibitors is lower than that of NS5B inhibitors. Option D: Treatment with first-generation EGFR-TKIs has been associated with the development of resistance through activating mutations in the EGFR gene. " A 934 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Ni+2] Question about this molecule: What is the right information about this molecule's resistance? Option A: It resists corrosion. Option B: Resistance to it among susceptible organisms is relatively low. Option C: It has low corrosion resistance. Option D: It resists corrosion even at high temperatures. " D 45375808 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3 Question about this molecule: What is the right information about this molecule's resistance? Option A: It resists corrosion even at high temperatures. Option B: Resistance to it among susceptible organisms is relatively low. Option C: It exhibits a high barrier to the development of resistance. Option D: It is effective where resistance to organophosphate insecticides has developed. " C 5757 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)O Question about this molecule: What is the right information about this molecule's resistance? Option A: It has low corrosion resistance. Option B: It has increased resistance to metabolism. Option C: It resists corrosion even at high temperatures. Option D: It exhibits a high barrier to the development of resistance. " B 48132 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1([C@H]([C@H]1C(=O)O[C@H](C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C(C(Br)(Br)Br)Br)C Question about this molecule: What is the right information about this molecule's resistance? Option A: Insects with certain mutations in their sodium channel gene may be resistant to pyrethroid insecticides. Option B: The barrier for development of resistance to NS3/4A inhibitors is lower than that of NS5B inhibitors. Option C: It remains a valuable option in the face of growing resistance to front-line antibiotics such as β-lactams and cephalosporins. Option D: It can cause resistance in insects with certain mutations in their sodium channel gene to pyrethroid insecticides. " A 5281874 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=C(C(=C1F)F)COC(=O)C2C(C2(C)C)/C=C(/C(F)(F)F)\\Cl)F)F Question about this molecule: What is the right information about this molecule's resistance? Option A: Insects with certain mutations in their sodium channel gene may be resistant to pyrethroid insecticides. Option B: It can cause resistance in insects with certain mutations in their sodium channel gene to pyrethroid insecticides. Option C: It remains a valuable option in the face of growing resistance to front-line antibiotics such as β-lactams and cephalosporins. Option D: The barrier for development of resistance to NS3/4A inhibitors is lower than that of NS5B inhibitors. " A 6279 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1C[C@@H]2[C@H](CC[C@]3([C@H]2CC[C@@]3(C(=O)C)OC(=O)C)C)[C@@]4(C1=CC(=O)CC4)C Question about this molecule: What is the right information about this molecule's resistance? Option A: It has a significantly higher barrier to resistance than the first generation NS5A inhibitors, such as [DB09027] and [DB09102]. Option B: It remains a valuable option in the face of growing resistance to front-line antibiotics such as β-lactams and cephalosporins. Option C: It is more resistant to metabolism for improved pharmacokinetic properties. Option D: It has a very high potency and reduces the chance of resistance compared to other NNRTI's. " C 36294 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)N)O)O)O[C@@H]3[C@@H](C[C@@H]([C@H](O3)CN)O)N)N Question about this molecule: What is the right information about this molecule's resistance? Option A: Treatment with first-generation EGFR-TKIs has been associated with the development of resistance through activating mutations in the EGFR gene. Option B: It has a significantly higher barrier to resistance than the first generation NS5A inhibitors, such as [DB09027] and [DB09102]. Option C: It remains a valuable option in the face of growing resistance to front-line antibiotics such as β-lactams and cephalosporins. Option D: It is resistant to enzymatic hydrolysis by some general proteases, such as pepsin, trypsin, collagenase, and chymotrypsin. " C 71496458 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC Question about this molecule: What is the right information about this molecule's resistance? Option A: It has a significantly higher barrier to resistance than the first generation NS5A inhibitors, such as [DB09027] and [DB09102]. Option B: Treatment with first-generation EGFR-TKIs has been associated with the development of resistance through activating mutations in the EGFR gene. Option C: The barrier to the development of resistance to NS5A inhibitors is lower than that of NS5B inhibitors. Option D: The barrier for development of resistance to NS3/4A inhibitors is lower than that of NS5B inhibitors. " B 15965 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=C(C(=NC(=C1Cl)Cl)C(=O)O)Cl)N Question about this molecule: What is the right information about this molecule's resistance? Option A: Most grasses are resistant to it. Option B: It is resistant to penicillinase. Option C: Resistance to it among susceptible organisms is relatively low. Option D: It is resistant to other penicillins, except those caused by MRSA. " A 47326 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C(C1(C)C)C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C Question about this molecule: What is the right information about this molecule's resistance? Option A: It remains a valuable option in the face of growing resistance to front-line antibiotics such as β-lactams and cephalosporins. Option B: It can cause resistance in insects with certain mutations in their sodium channel gene to pyrethroid insecticides. Option C: The barrier for development of resistance to NS3/4A inhibitors is lower than that of NS5B inhibitors. Option D: Insects with certain mutations in their sodium channel gene may be resistant to pyrethroid insecticides. " B 9223 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CO2 Question about this molecule: What is the right information about this molecule's resistance? Option A: It has low corrosion resistance. Option B: It resists corrosion even at high temperatures. Option C: It resists corrosion. Option D: Resistance to it among susceptible organisms is relatively low. " C 24462 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]S(=O)(=O)[O-].[Cu+2] Question about this molecule: What is the right information about this molecule's resistance? Option A: It has increased resistance to metabolism. Option B: It has low corrosion resistance. Option C: It exhibits a high barrier to the development of resistance. Option D: It resists corrosion even at high temperatures. " B 14969 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@H]([C@@](C[C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)[C@H]([C@H](C(=O)N[C@H](C(=O)N[C@H]5C(=O)N[C@@H]7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)[C@H](NC(=O)[C@H]([C@@H](C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)[C@@H](CC(C)C)NC)O)Cl)CO)O)O)(C)N)O Question about this molecule: What is the right information about this molecule's resistance? Option A: There is no cross-resistance between it and other antibiotics. Option B: The barrier for development of resistance to NS3/4A inhibitors is lower than that of NS5B inhibitors. Option C: It remains a valuable option in the face of growing resistance to front-line antibiotics such as β-lactams and cephalosporins. Option D: Mupirocin does not demonstrate cross-resistance with other classes of antimicrobial agents. " A 12797557 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[C@@H](C1=CC=C(C=C1)OC(F)F)C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3 Question about this molecule: What is the right information about this molecule's resistance? Option A: The barrier for development of resistance to NS3/4A inhibitors is lower than that of NS5B inhibitors. Option B: It can cause resistance in insects with certain mutations in their sodium channel gene to pyrethroid insecticides. Option C: It remains a valuable option in the face of growing resistance to front-line antibiotics such as β-lactams and cephalosporins. Option D: Insects with certain mutations in their sodium channel gene may be resistant to pyrethroid insecticides. " B 9570071 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(/C=N/OC(=O)NC)SC Question about this molecule: What is the right information about this molecule's resistance? Option A: It resists corrosion even at high temperatures. Option B: Resistance to it among susceptible organisms is relatively low. Option C: It is effective where resistance to organophosphate insecticides has developed. Option D: It exhibits a high barrier to the development of resistance. " C 4189 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl Question about this molecule: What is the right information about this molecule's resistance? Option A: Most grasses are resistant to it. Option B: It is resistant to other penicillins, except those caused by MRSA. Option C: Resistance to it among susceptible organisms is relatively low. Option D: It is resistant to penicillinase. " C 53025 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C(=NN=N1)SCC2=C(N3[C@@H]([C@@](C3=O)(NC(=O)C4SC(=C(C(=O)N)C(=O)O)S4)OC)SC2)C(=O)O Question about this molecule: What is the right information about this molecule's resistance? Option A: It is highly resistant to a broad spectrum of beta-lactamases. Option B: Most grasses are resistant to it. Option C: It is resistant to beta-lactamases. Option D: It is resistant to penicillinase. " A 8255 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=C)C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Contact with the liquid may cause frostbite by evaporative cooling. Option B: Contact with the liquid may cause frostbite. Option C: It can cause frostbite upon contact with the liquid. Option D: Contact with the liquid can cause frostbite. " C 5280343 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent liver injury. Option B: It has not been found to be associated with serum enzyme elevations during therapy or to instances of clinically apparent liver injury. Option C: It is well tolerated and has not been linked to serum enzyme elevations or to episodes of clinically apparent liver injury. Option D: It has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury. " C 280 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)=O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is noncombustible and nontoxic. Option B: It is non-toxic and safe to handle. Option C: It is generally considered safe. Option D: It is generally considered safe by the FDA. " A 134780 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)N Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent acute liver injury. Option B: It is associated with a low rate of serum aminotransferase elevations during therapy and has been implicated in causing rare instances of clinically apparent liver injury which can be severe. Option C: It has been associated with a low rate of serum aminotransferase elevations during therapy, but it has not been linked to instances of clinically apparent acute liver injury. Option D: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of clinically apparent acute liver injury. " B 6167 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option B: It has not been associated with liver test abnormalities or with clinically apparent hepatotoxicity. Option C: It has not been associated with acute liver injury or liver test abnormalities except with serious overdoses. Option D: It has not been associated with serum enzyme elevations or with instances of clinically apparent liver injury with jaundice. " C 2268 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=S)(OC)SCN1C(=O)C2=CC=CC=C2N=N1 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when taken with CYP inhibitors or grapefruit juice. Option B: In case of damage to, leaking from containers of this material contact CHEMTREC, 800-424-9300. Option C: It does not appear to be a significant cause of drug induced liver injury, but can be associated with flares of the underlying hepatitis B either during therapy or upon withdrawal. Option D: The potential of it to cause hepatotoxicity and the greater safety of newer anesthetics has led to a decrease in its use, currently limited to special situations, particularly in children. " B 119570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN[C@H]1CCC2=C(C1)SC(=N2)N Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has been linked to a low rate of serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury. Option B: It is associated with a low rate of transient serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury with jaundice. Option C: It is associated with a low rate of transient serum enzyme elevations during treatment, but has not been implicated in cases of clinically apparent acute liver injury. Option D: It is associated with a low rate of transient serum enzyme elevations during therapy, but has not been linked convincingly to cases of clinically apparent acute liver injury. " C 5584 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CN1C2=CC=CC=C2CCC3=CC=CC=C31)CN(C)C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It was not associated with an increased rate of serum aminotransferase elevations in prelicensure clinical trials, and it has not been linked to instances of clinically apparent acute liver injury. Option B: It has been associated with a low rate of serum aminotransferase elevations during therapy, but it has not been linked to instances of clinically apparent acute liver injury. Option C: In clinical trials, it was not associated with an increased rate of elevations in serum aminotransferase levels, and it has yet to be linked to instances of clinically apparent acute liver injury. Option D: In premarketing clinical trials, it was not associated with an increased rate of elevations in serum aminotransferase levels, and it has yet to be linked to instances of clinically apparent acute liver injury. " C 2520 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. Option B: It has a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent acute liver injury. Option C: It has been linked to a low rate of serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury. Option D: It has a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. " C 2719 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has been linked to a low rate of serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury. Option B: Its therapy is associated with low rates of serum enzyme elevations and has been linked to only rare cases of clinically apparent liver injury. Option C: It is not associated with serum enzyme elevations and is an extremely rare cause of clinically apparent acute liver injury. Option D: It has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. " C 54726191 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1CCO[C@@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of serum aminotransferase elevations during therapy and has not been linked to instances of clinically apparent acute liver injury. Option B: It is associated with a low rate of serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent acute liver injury. Option C: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of clinically apparent acute liver injury. Option D: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of acute, clinically apparent liver injury. " D 2477 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with serum enzyme elevations during therapy or with published instances of clinically apparent liver injury. Option B: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option C: It has not been associated with serum enzyme elevations or with instances of clinically apparent liver injury with jaundice. Option D: It is an infrequent cause of serum enzyme elevations and has not been linked to instances of clinically apparent liver injury with jaundice. " D 3162 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C1=CC=CC=C1)(C2=CC=CC=N2)OCCN(C)C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with instances of clinically apparent liver injury. Option B: It has not been linked to instances of clinically apparent liver injury. Option C: It has not been linked to instances of clinically apparent, acute liver injury. Option D: It has not been linked to instances of clinically apparent acute liver injury. " D 10311306 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC[C@]2(CC[C@]3(CCC(=O)N3)CN2)C4=CC=CC=C4 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option B: It has not been associated with serum enzyme elevations during therapy or with published instances of clinically apparent liver injury. Option C: It has not been associated with serum enzyme elevations during therapy or with clinically apparent liver injury. Option D: It has not been associated with serum enzyme elevations or with instances of clinically apparent liver injury with jaundice. " D 6918837 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of transient serum enzyme elevations during therapy, but has not been linked convincingly to cases of clinically apparent acute liver injury. Option B: It is associated with modest rate of minor serum enzyme elevations during therapy, but has not been linked to cases of clinically apparent liver injury. Option C: It is associated with a low rate of transient serum enzyme elevations during treatment, but has not been implicated in cases of clinically apparent acute liver injury. Option D: It is associated with a low rate of serum enzyme elevations during treatment, but has not been linked to instances of clinically apparent acute liver injury. " B 5281004 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC1O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@@]5([C@H]4[C@H](C[C@@]3([C@@]2(O1)C(=O)CO)C)O)C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with serum enzyme elevations during therapy or with published instances of clinically apparent liver injury. Option B: It has not been associated with serum enzyme elevations during therapy or with clinically apparent liver injury. Option C: Neither inhalant nor oral it has been linked to serum enzyme elevations during therapy or to convincing instances of clinically apparent acute liver injury. Option D: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. " C 7845 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC=C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Contact with the liquid may cause frostbite by evaporative cooling. Option B: Contact with the liquid may cause frostbite. Option C: Contact with the liquid can cause frostbite. Option D: It can cause frostbite upon contact with the liquid. " C 785 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: The amounts found in typical supplements has not been associated with serum enzyme elevations or with clinically apparent liver injury. Option B: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option C: Increased skin tumor incidence has been reported in mice treated dermally. Option D: An increased incidence of tumors was not observed in mice exposed by either gavage or injection. " C 151166 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=C(C=C1)NC2=C(C=CC=C2Cl)F)CC(=O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It was withdrawn from the market worldwide following reports of adverse reactions, including reports of carcinogenicity in animal studies. Option B: It has not been associated with worsening of serum enzyme elevations during therapy or with cases of clinically apparent liver injury with jaundice. Option C: Australia's Therapeutic Goods Administration (TGA, the Australian equivalent of the FDA) cancelled the registration of it in Australia due to concerns that it may cause liver failure. Option D: It has been associated with rare instances of serum enzyme elevations during treatment, but has not been linked to cases of clinically apparent liver injury with jaundice. " C 25154714 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[C@@H](C(=O)N1CCC[C@H]1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)[C@@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)OC)NC(=O)OC Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a modest rate of minor serum enzyme elevations during therapy, but it has not been linked to cases of clinically apparent liver injury. However, it has been reported to cause reactivation of hepatitis B. Option B: It was the first drug with demonstrated safety and therapeutic efficacy in treating HCV genotype 3 without the need for co-administration of interferon or [DB00811]. Option C: It does not appear to be a significant cause of drug induced liver injury, but can be associated with flares of the underlying hepatitis B either during therapy or upon withdrawal. Option D: It does not appear to be a significant cause of drug-induced liver injury, but initiation of therapy and sudden withdrawal of therapy can induce a transient exacerbation of the underlying hepatitis B. " B 5910 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@H]1[C@H](COC1=O)CC2=CN=CN2C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury. Option B: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option C: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent liver injury. Option D: It has not been found to be associated with serum enzyme elevations during therapy or to instances of clinically apparent liver injury. " C 656671 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]S(=O)S(=O)(=O)[O-].[Na+].[Na+] Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Contact with the unconfined liquid may cause frostbite by evaporative cooling. Option B: Contact with the unconfined liquid can cause frostbite by evaporative cooling and chemical type burns. Option C: Contact with the liquid may cause frostbite by evaporative cooling. Option D: It is noncombustible, but may decompose to emit toxic oxide fumes of sulfur and sodium when heated to high temperature. " D 9625 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(F)(F)(Cl)Br Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Exposure of the container to prolonged heat or fire can cause it to rupture violently and rocket. Option B: Exposure to prolonged heat or fire can cause it to rupture violently and rocket. Option C: It may rupture violently and rocket when exposed to prolonged heat or fire. Option D: Prolonged exposure to fire or heat may cause violent rupturing and rocketing. " C 92786 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(CC[C@H](C4)O)C)C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has been associated with a low rate of serum aminotransferase elevations during therapy, but it has not been linked to instances of clinically apparent acute liver injury. Option B: In clinical trials, it was not associated with an increased rate of elevations in serum aminotransferase levels, and it has yet to be linked to instances of clinically apparent acute liver injury. Option C: In premarketing clinical trials, it was not associated with an increased rate of elevations in serum aminotransferase levels, and it has yet to be linked to instances of clinically apparent acute liver injury. Option D: It was not associated with an increased rate of serum aminotransferase elevations in prelicensure clinical trials, and it has not been linked to instances of clinically apparent acute liver injury. " D 4095 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has been associated with rare instances of serum enzyme elevations during treatment, but has not been linked to cases of clinically apparent liver injury with jaundice. Option B: It has not been associated with worsening of serum enzyme elevations during therapy or with cases of clinically apparent liver injury with jaundice. Option C: It has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury, even in patients with underlying chronic viral hepatitis. Option D: It has not been associated with serum enzyme elevations during therapy or with cases of clinically apparent liver injury with jaundice, but its general use has been quite limited. " C 6137 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CSCC[C@@H](C(=O)O)N Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Eugenol in therapeutic doses has not been implicated in causing serum enzyme elevations or clinically apparent liver injury, but ingestions of high doses, as with an overdose, can cause severe liver injury. Option B: The use of it is pending revision due to safety concerns in regards to an increased risk of severe exacerbation of asthma symptoms, leading to hospitalization as well as death in some patients using long-acting beta agonists for the treatment of asthma. Option C: It can be considered safe in amounts exceeding 2-3 times the minimal recommended daily intake, although hypermethionemia or hyperhomocysteinemia may occur in specific cases of congenital enzyme deficiency, prematurity, or diminished liver function. Option D: Therapy with this molecule has been associated with a low rate of serum enzyme elevations, but has not been linked to cases of clinically apparent acute liver injury, although it can cause severe hypersensitivity infusion reactions which in some instances can be associated with acute liver injury. " C 8461 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: What is the right information about this molecule's safety concerns? Option A: The amounts found in typical supplements has not been associated with serum enzyme elevations or with clinically apparent liver injury. Option B: Neither inhalant nor oral it has been linked to serum enzyme elevations during therapy or to convincing instances of clinically apparent acute liver injury. Option C: No significant increase in cancer mortality was observed in workers occupationally exposed to it by inhalation. Option D: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. " C 5281081 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)C(=O)/C(=C/C1=CC(=C(C(=C1)O)O)[N+](=O)[O-])/C#N Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of transient serum enzyme and bilirubin elevations during therapy, and has been implicated in rare cases of clinically apparent acute liver injury with jaundice. Option B: It is associated with a low rate of transient serum enzyme and bilirubin elevations during therapy, but has only rarely been implicated in cases of clinically apparent acute liver injury with jaundice. Option C: It has been associated with a low rate of serum enzyme elevations during treatment, but has yet to be implicated in cases of clinically apparent acute liver injury with jaundice. Option D: It is associated with a low rate of transient serum enzyme and bilirubin elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury with jaundice. " C 5486971 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C[C@@H](CC(=O)O)CN Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with serum aminotransferase elevations and has not been linked to cases of clinically apparent liver injury. Option B: It is not associated with serum aminotransferase elevations, and clinically apparent liver injury from it appears to be quite rare. Option C: Therapy with it is not associated with serum aminotransferase elevations, and cases of clinically apparent liver injury from it have been reported but are very rare. Option D: It is not associated with serum aminotransferase elevations, but several cases of clinically apparent liver injury from it have been reported. " B 7367 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(Cl)(Cl)Cl Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has been linked to rare instances of clinically apparent liver injury with jaundice. Option B: It burns skin and eyes. Option C: It may burn skin, eyes, and mucous membranes. Option D: It burns skin, eyes, and mucous membranes. " D 4775 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)CCCC(=O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Neither phenylbutyrate nor sodium benzoate have been linked to cases of liver injury either in the form of serum enzyme elevations during therapy or clinically apparent acute liver injury. Option B: Chronic therapy with this molecule has not been associated with serum enzyme elevations, but has been linked to rare cases of mild, clinically apparent liver injury. Option C: Neither inhalant nor oral it has been linked to serum enzyme elevations during therapy or to convincing instances of clinically apparent acute liver injury. Option D: Therapy with it has been associated with a low rate of serum enzyme elevations, but has not been clearly linked to cases of clinically apparent acute liver injury. " A 674 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Contact with the unconfined liquid can cause frostbite by evaporative cooling and chemical type burns. Option B: Contact with the liquid may cause frostbite by evaporative cooling. Option C: Contact with the liquid may cause frostbite. Option D: Contact with the unconfined liquid may cause frostbite by evaporative cooling. " A 265237 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=O)O[C@H](C1)[C@@H](C)[C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3C[C@@H]5[C@]6([C@@]4(C(=O)C=C[C@@H]6O)C)O5)C)CO Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has been linked to a low rate of serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury. Option B: It has not been implicated in causing serum enzyme elevations during therapy, but recently has been implicated in rare cases of clinically apparent liver injury. Option C: It is associated with a low rate of transient serum enzyme elevations during treatment, but has not been implicated in cases of clinically apparent acute liver injury. Option D: It is associated with a low rate of transient serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury with jaundice. " B 6579 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC(=O)N Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Chronic therapy with this molecule has not been associated with serum enzyme elevations, but has been linked to rare cases of mild, clinically apparent liver injury. Option B: It has not been associated with serum enzyme elevations during therapy or with cases of clinically apparent liver injury with jaundice, but its general use has been quite limited. Option C: Low levels of it in the diet are not a concern for neurotoxicity or reproductive toxicity in humans, although further research is needed to study the long-term, low-level cumulative effects on the nervous system. Option D: Therapy with it has been associated with a low rate of serum enzyme elevations, but has not been clearly linked to cases of clinically apparent acute liver injury. " C 5284603 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)OC)O4)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent liver injury. Option B: It has not been found to be associated with serum enzyme elevations during therapy or to instances of clinically apparent liver injury. Option C: It has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury. Option D: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. " C 5282448 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CO[C@@H]1[C@@H]([C@H]([C@@H]([C@H](O1)COS(=O)(=O)O)O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](O2)C(=O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)COS(=O)(=O)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)C(=O)O)O[C@@H]5[C@@H]([C@H]([C@@H]([C@H](O5)COS(=O)(=O)O)O)O)NS(=O)(=O)O)O)O)OS(=O)(=O)O)NS(=O)(=O)O)O)OS(=O)(=O)O)O)NS(=O)(=O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of transient elevations in serum aminotransferase levels during therapy, but has not been convincingly linked to cases of clinically apparent liver injury with jaundice. Option B: It is associated with transient and usually mild elevations in serum aminotransferase during therapy, but has not been convincingly linked to cases of clinically apparent liver injury. Option C: It is associated with a moderate rate of transient elevations in serum aminotransferase during therapy, but has not been linked to instances of clinically apparent liver injury. Option D: It has been associated with a low rate of serum aminotransferase elevations during therapy, but has not been implicated in cases of clinically apparent, idiosyncratic liver injury. " D 4616 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with serum aminotransferase or alkaline phosphatase elevations, and clinically apparent liver injury from it has not been reported and must be very rare, if it occurs at all. Option B: It has not been associated with serum aminotransferase elevations during therapy, and clinically apparent liver injury from this molecule has yet to be reported and must be rare, if it occurs at all. Option C: It has not been associated with serum aminotransferase or alkaline phosphatase elevations, and clinically apparent liver injury from it has been reported, but is very rare. Option D: Therapy with it has not been associated with serum aminotransferase elevations, and clinically apparent liver injury from it has yet to be reported and must be rare, if it occurs at all. " A 40585 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1([C@H]([C@H]1C(=O)O[C@H](C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C=C(Br)Br)C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is highly toxic to aquatic life, particularly fish, and therefore must be used with extreme caution around water. Option B: It has not been associated with serum enzyme elevations during therapy or with published instances of clinically apparent liver injury. Option C: Sometimes, it is dyed dark brown during production to alert people to its hazards. Option D: The amounts found in typical supplements has not been associated with serum enzyme elevations or with clinically apparent liver injury. " A 5665 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC(CCC(=O)O)N Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been convincingly linked to cases of clinically apparent liver injury, but was linked to a fatal case of Reye syndrome in a child with severe developmental delay. Option B: It is associated with a low rate of transient serum enzyme elevations during treatment, but has not been implicated in cases of clinically apparent acute liver injury. Option C: It is associated with a low rate of transient serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury with jaundice. Option D: Therapy with it has been associated with a low rate of serum enzyme elevations, but has not been clearly linked to cases of clinically apparent acute liver injury. " A 2130 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C2CC3CC1CC(C2)(C3)N Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with instances of clinically apparent liver injury. Option B: It has not been linked to instances of clinically apparent liver injury. Option C: It has not been linked to episodes of clinically apparent liver injury. Option D: It has not been associated with clinically apparent liver injury. " D 2118 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NN=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Therapy with it has not been associated with serum aminotransferase elevations, and clinically apparent liver injury from it has yet to be reported and must be rare, if it occurs at all. Option B: It has not been associated with serum aminotransferase elevations during therapy, and clinically apparent liver injury from this molecule has yet to be reported and must be rare, if it occurs at all. Option C: It has not been associated with serum aminotransferase or alkaline phosphatase elevations, and clinically apparent liver injury from it has been reported, but is very rare. Option D: It has not been associated with serum aminotransferase or alkaline phosphatase elevations, and clinically apparent liver injury from it has not been reported and must be very rare, if it occurs at all. " C 6256 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of transient serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury with jaundice. Option B: It is associated with a low rate of transient serum enzyme elevations during treatment, but has not been implicated in cases of clinically apparent acute liver injury. Option C: It has been linked to a low rate of serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury. Option D: It is associated with a low rate of transient serum enzyme elevations during therapy, but has not been linked convincingly to cases of clinically apparent acute liver injury. " A 6212 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)(Cl)Cl Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It will burn only when it reaches very high temperatures. Option B: May burn if heated to high temperatures. Option C: It has been linked to rare instances of clinically apparent liver injury with jaundice. Option D: It has been linked to rare instances of clinically apparent acute liver injury. " A 2809 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)C(=O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with serum aminotransferase or alkaline phosphatase elevations, and clinically apparent liver injury from it has been reported, but is very rare. Option B: It has not been associated with serum aminotransferase or alkaline phosphatase elevations, and clinically apparent liver injury from it has not been reported and must be very rare, if it occurs at all. Option C: Therapy with it is not associated with serum aminotransferase elevations, and cases of clinically apparent liver injury from it have been reported but are very rare. Option D: Therapy with it has not been associated with serum aminotransferase elevations, and clinically apparent liver injury from it has yet to be reported and must be rare, if it occurs at all. " C 3394 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. Option B: It has been linked to a low rate of serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury. Option C: It has a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent acute liver injury. Option D: It has a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. " B 4054 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC12CC3CC(C1)(CC(C3)(C2)N)C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a minimal rate of serum enzyme elevations during therapy and has only rarely been implicated as a cause of clinically apparent acute liver injury. Option B: It is associated with a low rate of transient serum enzyme elevations during treatment, but has not been implicated in cases of clinically apparent acute liver injury. Option C: It is associated with a minimal rate of serum enzyme elevations during therapy and has only rarely been implicated as a cause of clinically apparent liver injury. Option D: It is associated with a low rate of serum enzyme elevations during treatment and has been implicated in rare instances of clinically apparent, acute liver injury. " A 66265 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN[C@@H](C)CC1=CC(=CC=C1)C(F)(F)F Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Following multiple concerns about the cardiovascular side-effects of the drug, such approval was withdrawn. Option B: It was withdrawn from the market worldwide following reports of adverse reactions, including reports of carcinogenicity in animal studies. Option C: It was withdrawn from markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. Option D: It has not been associated with serum enzyme elevations during therapy or with published instances of clinically apparent liver injury. " A 45375808 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with worsening of serum enzyme elevations during therapy or with cases of clinically apparent liver injury with jaundice. Option B: It has not been associated with serum enzyme elevations during therapy or with cases of clinically apparent liver injury with jaundice, but its general use has been quite limited. Option C: Elevations in serum enzyme levels during therapy are uncommon, and it has not been implicated convincingly in cases of clinically apparent liver injury with jaundice. Option D: It has been associated with rare instances of serum enzyme elevations during treatment, but has not been linked to cases of clinically apparent liver injury with jaundice. " C 2202 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C2=C(C(=CC=C2)O)C(=O)C3=C1C=CC=C3O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It does not appear to be a significant cause of drug-induced liver injury, but initiation of therapy and sudden withdrawal of therapy can induce a transient exacerbation of the underlying hepatitis B. Option B: It does not appear to be a significant cause of drug induced liver injury, but can be associated with flares of the underlying hepatitis B either during therapy or upon withdrawal. Option C: The potential of it to cause hepatotoxicity and the greater safety of newer anesthetics has led to a decrease in its use, currently limited to special situations, particularly in children. Option D: The drug is relatively innocuous, yet effective, and systemic side effects have not been observed with it, in contrast to a wide variety of systemic and topical therapies for psoriasis. " D 3658 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(CCN1CCOCCO)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to instances of clinically apparent, acute liver injury. Option B: It has not been associated with instances of clinically apparent liver injury. Option C: It has not been linked to instances of clinically apparent acute liver injury. Option D: It has not been linked to instances of clinically apparent liver injury. " C 6397 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[Si](C)(C)Cl Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Contact with the liquid causes painful burns. Option B: It may cause burns. Option C: It has rarely been linked to instances of clinically apparent liver injury. Option D: It can cause thermal burns. " B 30323 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of transient serum enzyme and bilirubin elevations during therapy, and has been implicated in rare cases of clinically apparent acute liver injury with jaundice. Option B: It is associated with a low rate of transient serum enzyme and bilirubin elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury with jaundice. Option C: It is associated with a low rate of transient serum enzyme and bilirubin elevations during therapy, but has only rarely been implicated in cases of clinically apparent acute liver injury with jaundice. Option D: It is associated with a low rate of transient serum enzyme elevations during therapy and has only rarely been implicated in cases of clinically apparent acute liver injury with jaundice. " B 4192 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NC=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4F Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with serum aminotransferase elevations during therapy or episodes of acute, clinically apparent liver injury. Option B: It has not been associated with serum aminotransferase elevations or cases of clinically apparent acute liver injury. Option C: It has not been associated with serum aminotransferase elevations during therapy or instances of clinically apparent acute liver injury. Option D: It has not been associated with serum aminotransferase elevations and has not been linked to cases of clinically apparent liver injury. " D 92253 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCN1CCCC[C@H]1C(=O)NC2=C(C=CC=C2C)C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with serum enzyme elevations during therapy or with published instances of clinically apparent liver injury. Option B: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option C: The occurrence of adverse effects is not anticipated much if at all when administered appropriately. Option D: Clinically apparent liver injury from it has not been reported and must be rare if it occurs at all. " C 5487427 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+]1([C@@H]2CC(C[C@H]1[C@H]3[C@@H]2O3)OC(=O)C(C4=CC=CS4)(C5=CC=CS5)O)C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been implicated in causing serum enzyme elevations or clinically apparent liver injury. Option B: It has not been linked to either serum enzyme elevations or to clinically apparent acute liver injury. Option C: It has not been associated with serum enzyme elevations or clinically apparent liver injury. Option D: It has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury. " D 8252 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC=C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Contact with the liquid may cause frostbite. Option B: Contact with the liquid may cause frostbite by evaporative cooling. Option C: Contact with the liquid can cause frostbite. Option D: It can cause frostbite upon contact with the liquid. " C 5284596 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has at least moderate potential to be abused by humans. Option B: It has not been associated with clinically apparent liver injury. Option C: Administration of it is associated with very few side effects. Option D: It has not been shown to cause clinically apparent liver injury. " C 947 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: N#N Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is noncombustible and nontoxic. Option B: It is generally considered safe by the FDA. Option C: It is generally considered safe. Option D: It is non-toxic and safe to handle. " A 4634 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CC#CCOC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with serum enzyme elevations or clinically apparent liver injury. Option B: It has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury. Option C: It has not been implicated in causing serum enzyme elevations or clinically apparent liver injury. Option D: It has not been linked to either serum enzyme elevations or to clinically apparent acute liver injury. " B 6338 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCl Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Contact with the liquid may cause frostbite. Option B: Contact with the liquid may cause frostbite by evaporative cooling. Option C: Contact with the unconfined liquid may cause frostbite by evaporative cooling. Option D: Contact with the unconfined liquid can cause frostbite by evaporative cooling and chemical type burns. " C 6324 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Contact with the liquid may cause frostbite. Option B: Contact with the liquid can cause frostbite. Option C: It can cause frostbite upon contact with the liquid. Option D: Contact with the liquid may cause frostbite by evaporative cooling. " A 59768 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(COC1=CC=C(C=C1)CCC(=O)OC)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to episodes of clinically apparent liver injury. Option B: It has not been linked to instances of clinically apparent drug induced liver injury. Option C: It has not been associated with instances of clinically apparent liver injury. Option D: It has not been linked to instances of clinically apparent drug-induced liver injury. " D 60164 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C=C(C=C1)C2=CC3=C(C=C2)C=C(C=C3)C(=O)O)C45CC6CC(C4)CC(C6)C5 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: The amounts found in typical supplements has not been associated with serum enzyme elevations or with clinically apparent liver injury. Option B: Appropriate usage of the chemical at the recommended dosages and routes of administration have generally proven to be safe. Option C: It has a superior safety profile compared to tretinoin. Option D: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. " C 60172 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC(=C2C(=N1)N(C=N2)CCOCP(=O)(O)O)N Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It does not appear to be a significant cause of drug-induced liver injury, but initiation of therapy and sudden withdrawal of therapy can induce a transient exacerbation of the underlying hepatitis B. Option B: It is associated with a modest rate of minor serum enzyme elevations during therapy, but it has not been linked to cases of clinically apparent liver injury. However, it has been reported to cause reactivation of hepatitis B. Option C: It is frequently associated with serum enzyme elevations, but more importantly, it has been linked to rapid onset, severe hypersensitivity reactions that can be associated with acute hepatic necrosis, liver failure, and death. Option D: It does not appear to be a significant cause of drug induced liver injury, but can be associated with flares of the underlying hepatitis B either during therapy or upon withdrawal. " A 3652 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Its therapy has not been associated with liver function abnormalities and is an extremely rare cause of clinically apparent acute liver injury. Option B: Therapy with it has been associated with a low rate of serum enzyme elevations, but has not been clearly linked to cases of clinically apparent acute liver injury. Option C: It has been linked to low rates of transient and asymptomatic serum enzyme elevations during therapy but has not been associated with instances of clinically apparent acute liver injury. Option D: It has not been associated with serum enzyme elevations during treatment and must be a very rare cause of clinically apparent acute liver injury, if it occurs at all. " A 2707 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)(Cl)Cl)(O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to either serum enzyme elevations or to clinically apparent acute liver injury. Option B: It has not been implicated in causing serum enzyme elevations or clinically apparent liver injury. Option C: It has not been associated with serum enzyme elevations or clinically apparent liver injury. Option D: It has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury. " B 3825 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has been linked to a low rate of serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury. Option B: It has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. Option C: It has a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent acute liver injury. Option D: It has a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. " A 60877 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@H](O[C@H](S1)CO)N2C=C(C(=NC2=O)N)F Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It does not appear to be a significant cause of drug induced liver injury, but can be associated with flares of the underlying hepatitis B either during therapy or upon withdrawal. Option B: It has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury, even in patients with underlying chronic viral hepatitis. Option C: It may cause flares of disease in patients with underlying chronic hepatitis B virus (HBV) infection. Option D: It does not appear to be a significant cause of drug-induced liver injury, but initiation of therapy and sudden withdrawal of therapy can induce a transient exacerbation of the underlying hepatitis B. " C 5311 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to instances of clinically apparent liver injury. Option B: It has not been linked to episodes of clinically apparent liver injury. Option C: It has not been associated with instances of clinically apparent liver injury. Option D: It has not been linked to cases of clinically apparent liver injury. " D 5284371 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@H](C=C4)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury. Option B: It has not been found to be associated with serum enzyme elevations during therapy or to instances of clinically apparent liver injury. Option C: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option D: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent liver injury. " A 60854 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(CCN1CCC2=C(C=C3C(=C2)CC(=O)N3)Cl)C4=NSC5=CC=CC=C54 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with serum enzyme elevations during treatment nor to instances of clinically apparent acute liver injury. Option B: It has not been associated with serum enzyme elevations during treatment nor has it been implicated in cases of acute liver injury. Option C: It has not been associated with serum enzyme elevations during treatment and has not been linked to cases of clinically apparent acute liver injury. Option D: It has been linked to rare instances of hypersensitivity reactions accompanied by mild-to-moderate acute liver injury. " D 5284632 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC[N+]2(C1)[C@@H]3CC[C@H]2CC(C3)OC(=O)C(C4=CC=CC=C4)(C5=CC=CC=C5)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with serum enzyme elevations or clinically apparent liver injury. Option B: It has not been linked to either serum enzyme elevations or to clinically apparent acute liver injury. Option C: It has not been implicated in causing serum enzyme elevations or clinically apparent liver injury. Option D: It has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury. " D 5509 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)C(=O)C2=CC=C(N2C)CC(=O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to instances of clinically apparent drug-induced liver injury. Option B: It has not been linked to instances of clinically apparent drug induced liver injury. Option C: It has not been associated with instances of clinically apparent liver injury. Option D: It has been linked to rare instances of clinically apparent drug induced liver injury. " D 8094 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCC(=O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It burns skin and eyes. Option B: It burns skin, eyes, and mucous membranes. Option C: It may burn skin, eyes, and mucous membranes. Option D: It has been linked to rare instances of clinically apparent liver injury with jaundice. " C 14985 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C2=C(CC[C@@](O2)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C(=C1O)C)C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is generally considered safe by the FDA. Option B: It has rarely been linked to instances of clinically apparent liver injury. Option C: It is generally considered safe. Option D: The pure compound is a dangerous explosive, particularly when dry. " A 637568 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)/C=C/C(=O)OC Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has been associated with rare instances of clinically apparent, acute liver injury. Option B: It has been linked to rare cases of clinically apparent acute liver injury. Option C: It has been linked to rare instances of clinically apparent liver injury with jaundice. Option D: It is associated with rare cases of clinically apparent acute liver injury with jaundice. " C 11304743 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C1=C(N=C(N=C1N)C2=NN(C3=C2C=CC=N3)CC4=CC=CC=C4F)N)C(=O)OC Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent liver injury. Option B: It has not been linked to significant serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. Option C: It has not been found to be associated with serum enzyme elevations during therapy or to instances of clinically apparent liver injury. Option D: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. " B 3117 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)C(=S)SSC(=S)N(CC)CC Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. Option B: It has not been linked to significant serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. Option C: It has not been associated with serum enzyme elevations during treatment nor to instances of clinically apparent acute liver injury. Option D: It has been linked to clinically apparent acute liver injury which can be severe and result in fatality. " D 54674461 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)NC1=C(N=C(N=C1N)C2=NN(C3=C2C=C(C=N3)F)CC4=CC=CC=C4F)N Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has a low rate of serum aminotransferase elevations during therapy and has not been linked to instances of clinically apparent acute liver injury. Option B: It is associated with a low rate of serum aminotransferase elevations during therapy and has not been linked to instances of clinically apparent acute liver injury. Option C: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of clinically apparent acute liver injury. Option D: It is associated with a low rate of serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent acute liver injury. " A 148124 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It does not appear to be a significant cause of drug-induced liver injury, but initiation of therapy and sudden withdrawal of therapy can induce a transient exacerbation of the underlying hepatitis B. Option B: It does not appear to be a significant cause of drug induced liver injury, but can be associated with flares of the underlying hepatitis B either during therapy or upon withdrawal. Option C: It is frequently associated with serum enzyme elevations, but more importantly, it has been linked to rapid onset, severe hypersensitivity reactions that can be associated with acute hepatic necrosis, liver failure, and death. Option D: It is associated with a modest rate of minor serum enzyme elevations during therapy, but it has not been linked to cases of clinically apparent liver injury. However, it has been reported to cause reactivation of hepatitis B. " C 2162 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. Option B: It has been linked to a low rate of serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury. Option C: It has a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent acute liver injury. Option D: It has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. " C 948 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N-]=[N+]=O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Prolonged exposure to fire or heat may cause violent rupturing and rocketing. Option B: It may rupture violently and rocket when exposed to prolonged heat or fire. Option C: Exposure to prolonged heat or fire can cause it to rupture violently and rocket. Option D: Exposure of the container to prolonged heat or fire can cause it to rupture violently and rocket. " C 5095 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN(CCC)CCC1=C2CC(=O)NC2=CC=C1 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of serum enzyme elevations during treatment and has been implicated in rare instances of clinically apparent, acute liver injury. Option B: It is associated with a low rate of serum enzyme elevations during treatment and to rare instances of clinically apparent, acute liver injury. Option C: It therapy is associated with low rate of transient serum enzyme elevations during treatment and has been implicated in rare cases of acute liver injury. Option D: It is associated with a low rate of transient serum enzyme elevations during treatment and has been implicated in rare cases of acute liver injury. " D 4771 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(CC1=CC=CC=C1)N Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked convincingly to either serum enzyme elevations during therapy or instances of clinically apparent liver injury. Option B: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent liver injury. Option C: It has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury. Option D: It has not been found to be associated with serum enzyme elevations during therapy or to instances of clinically apparent liver injury. " A 445154 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O)O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to either serum enzyme elevations or to clinically apparent acute liver injury. Option B: It has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury. Option C: It has not been associated with serum enzyme elevations or clinically apparent liver injury. Option D: It has not been implicated in causing serum enzyme elevations or clinically apparent liver injury. " C 5961 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(=O)N)[C@@H](C(=O)O)N Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with serum enzyme elevations during therapy or with clinically apparent liver injury. Option B: It has not been associated with worsening of serum enzyme elevations during therapy or with cases of clinically apparent liver injury with jaundice. Option C: It has not been linked to serum enzyme elevations during therapy and is an exceedingly rare cause of idiosyncratic clinically apparent acute liver injury. Option D: It has not been associated with serum enzyme elevations during therapy or instances of idiosyncratic acute liver injury. " D 4499 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of serum enzyme elevations, but it has not been specifically linked to instances of clinically apparent acute liver injury. Option B: Use of it is associated with a low rate of serum enzyme elevations during therapy but it has not been linked to instances of clinically apparent acute liver injury. Option C: It is associated with a low rate of serum enzyme elevations during treatment, but has not been linked to instances of clinically apparent acute liver injury. Option D: It is associated with a low rate of transient serum enzyme elevations during therapy, but has not been linked convincingly to cases of clinically apparent acute liver injury. " A 4091 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C(=N)N=C(N)N Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to serum enzyme elevations during therapy and is an exceedingly rare cause of idiosyncratic clinically apparent acute liver injury. Option B: It has not been associated with serum enzyme elevations during therapy or instances of idiosyncratic acute liver injury. Option C: It has not been associated with serum enzyme elevations during therapy or with clinically apparent liver injury. Option D: It has not been associated with worsening of serum enzyme elevations during therapy or with cases of clinically apparent liver injury with jaundice. " A 2375 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CS(=O)(=O)C1=CC=C(C=C1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of serum enzyme elevations during therapy and has been linked to rare instances of liver injury. Option B: It has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. Option C: It has a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent acute liver injury. Option D: It has a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. " A 36294 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)N)O)O)O[C@@H]3[C@@H](C[C@@H]([C@H](O3)CN)O)N)N Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has rarely been linked to instances of clinically apparent liver injury. Option B: It has been associated with rare instances of clinically apparent, acute liver injury. Option C: It has been linked to rare cases of clinically apparent acute liver injury. Option D: It has been linked to rare instances of clinically apparent acute liver injury. " A 5288826 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](C=C4)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option B: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent liver injury. Option C: It has not been found to be associated with serum enzyme elevations during therapy or to instances of clinically apparent liver injury. Option D: It has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury. " D 3333 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has been linked to a low rate of serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury. Option B: Therapy with it has been associated with a low rate of serum enzyme elevations, but has not been clearly linked to cases of clinically apparent acute liver injury. Option C: It is associated with a low rate of transient serum enzyme elevations during treatment, but has not been implicated in cases of clinically apparent acute liver injury. Option D: It has been associated with a low rate of serum enzyme elevations, but has not been convincingly linked to instances of clinically apparent, acute liver injury. " D 8263 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(C(C(C1(F)F)(F)F)(F)F)(F)F Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It may rupture violently and rocket when exposed to prolonged heat or fire. Option B: Exposure of the container to prolonged heat or fire can cause it to rupture violently and rocket. Option C: Exposure to prolonged heat or fire can cause it to rupture violently and rocket. Option D: Prolonged exposure to fire or heat may cause violent rupturing and rocketing. " B 4908 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CCCN)NC1=C2C(=CC(=C1)OC)C=CC=N2 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. Option B: It is not associated with serum enzyme elevations during therapy and has yet to be linked to instances of clinically apparent acute liver injury. Option C: It has not been linked to significant serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. Option D: It has not been found to be associated with serum enzyme elevations during therapy or to instances of clinically apparent liver injury. " B 2708 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has low rates of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. Option B: It has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. Option C: It has a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. Option D: It has been associated with low rates of serum enzyme elevations during therapy and to rare instances of acute, clinically apparent injury. " D 6518 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(CO[N+](=O)[O-])(CO[N+](=O)[O-])CO[N+](=O)[O-])O[N+](=O)[O-] Question about this molecule: What is the right information about this molecule's safety concerns? Option A: The pure compound is a dangerous explosive, particularly when dry. Option B: It is generally considered safe by the FDA. Option C: It is generally considered safe. Option D: It has rarely been linked to instances of clinically apparent liver injury. " A 3672 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CC1=CC=C(C=C1)C(C)C(=O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Therapy with it has been associated with a low rate of serum enzyme elevations, but has not been clearly linked to cases of clinically apparent acute liver injury. Option B: Chronic therapy with this molecule has not been associated with serum enzyme elevations, but has been linked to rare cases of mild, clinically apparent liver injury. Option C: It has not been associated with serum enzyme elevations during therapy or with cases of clinically apparent liver injury with jaundice, but its general use has been quite limited. Option D: It is considered to be among the safest NSAIDs and is generally well tolerated but can, nevertheless, rarely cause clinically apparent and serious acute liver injury. " D 213046 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC[C@H]([C@@H](C1)CN2CCN(CC2)C3=NSC4=CC=CC=C43)CN5C(=O)[C@H]6[C@@H]7CC[C@@H](C7)[C@H]6C5=O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of clinically apparent acute liver injury. Option B: It is associated with a low rate of serum aminotransferase elevations during therapy and has not been linked to instances of clinically apparent acute liver injury. Option C: It is associated with a low rate of serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent acute liver injury. Option D: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of acute, clinically apparent liver injury. " C 11715 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)CBr Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It can cause thermal burns. Option B: It may cause burns. Option C: It has rarely been linked to instances of clinically apparent liver injury. Option D: Contact with the liquid causes painful burns. " D 6918314 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N Question about this molecule: What is the right information about this molecule's safety concerns? Option A: In premarketing clinical trials, it was not associated with an increased rate of elevations in serum aminotransferase levels, and it has yet to be linked to instances of clinically apparent acute liver injury. Option B: It was not associated with an increased rate of serum aminotransferase elevations in prelicensure clinical trials, and it has not been linked to instances of clinically apparent acute liver injury. Option C: It has been associated with a low rate of serum aminotransferase elevations during therapy, but it has not been linked to instances of clinically apparent acute liver injury. Option D: In clinical trials, it was not associated with an increased rate of elevations in serum aminotransferase levels, and it has yet to be linked to instances of clinically apparent acute liver injury. " A 3562 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(F)(F)F)(Cl)Br Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It does not appear to be a significant cause of drug-induced liver injury, but initiation of therapy and sudden withdrawal of therapy can induce a transient exacerbation of the underlying hepatitis B. Option B: It does not appear to be a significant cause of drug induced liver injury, but can be associated with flares of the underlying hepatitis B either during therapy or upon withdrawal. Option C: The potential of it to cause hepatotoxicity and the greater safety of newer anesthetics has led to a decrease in its use, currently limited to special situations, particularly in children. Option D: It is associated with a modest rate of minor serum enzyme elevations during therapy, but it has not been linked to cases of clinically apparent liver injury. However, it has been reported to cause reactivation of hepatitis B. " C 23925 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Fe] Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with modest rate of minor serum enzyme elevations during therapy, but has not been linked to cases of clinically apparent liver injury. Option B: It has not been linked to serum enzyme elevations during therapy or to cases of clinically apparent liver injury. Option C: It has not been found to be associated with serum enzyme elevations during therapy or to instances of clinically apparent liver injury. Option D: It has little or no adverse effect on the liver when taken at the usual recommended daily allowance or in replacement doses. " D 3261 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C2=NN=CN2C3=C(C=C(C=C3)Cl)C(=N1)C4=CC=CC=C4 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Therapy with it has not been associated with serum aminotransferase elevations, and clinically apparent liver injury from it has yet to be reported and must be rare, if it occurs at all. Option B: Therapy with this molecule has not been associated with serum aminotransferase or alkaline phosphatase elevations, and clinically apparent liver injury from this molecule has not been reported and must be very rare, if it occurs at all. Option C: It has not been associated with serum aminotransferase or alkaline phosphatase elevations, and clinically apparent liver injury from it has not been reported and must be very rare, if it occurs at all. Option D: It has not been associated with serum aminotransferase elevations during therapy, and clinically apparent liver injury from this molecule has yet to be reported and must be rare, if it occurs at all. " B 3114 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)N(CCC(C1=CC=CC=C1)(C2=CC=CC=N2)C(=O)N)C(C)C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Long-term therapy is associated with a low rate of serum enzyme elevations and is a very rare cause of clinically apparent acute liver injury. Option B: Long term therapy with this molecule is associated with a low rate of serum enzyme elevations and is a rare cause of clinically apparent acute liver injury. Option C: It is associated with a low rate of transient and asymptomatic serum enzyme elevations and is a rare cause of clinically apparent acute liver injury. Option D: Long term therapy is associated with a low rate of serum enzyme elevations and is a rare cause of clinically apparent acute liver injury. " B 6360 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Contact with the liquid can cause frostbite. Option B: Contact with the liquid may cause frostbite by evaporative cooling. Option C: It can cause frostbite upon contact with the liquid. Option D: Contact with the liquid may cause frostbite. " A 56959 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CC(COC3=CC=CC=C3OC)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of transient serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury with jaundice. Option B: It is associated with a low rate of transient serum enzyme elevations during treatment, but has not been implicated in cases of clinically apparent acute liver injury. Option C: Therapy with it has been associated with a low rate of serum enzyme elevations, but has not been clearly linked to cases of clinically apparent acute liver injury. Option D: Chronic therapy with this molecule has not been associated with serum enzyme elevations, but has been linked to rare cases of mild, clinically apparent liver injury. " D 4927 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to instances of clinically apparent acute liver injury. Option B: It has not been linked to instances of clinically apparent, acute liver injury. Option C: It has not been linked to instances of clinically apparent liver injury. Option D: It has not been associated with instances of clinically apparent liver injury. " A 9854073 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)OC)C)OC Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Eugenol in therapeutic doses has not been implicated in causing serum enzyme elevations or clinically apparent liver injury, but ingestions of high doses, as with an overdose, can cause severe liver injury. Option B: It is frequently associated with serum enzyme elevations, but more importantly, it has been linked to rapid onset, severe hypersensitivity reactions that can be associated with acute hepatic necrosis, liver failure, and death. Option C: It is associated with a modest rate of minor serum enzyme elevations during therapy, but it has not been linked to cases of clinically apparent liver injury. However, it has been reported to cause reactivation of hepatitis B. Option D: Therapy with this molecule has been associated with a low rate of serum enzyme elevations, but has not been linked to cases of clinically apparent acute liver injury, although it can cause severe hypersensitivity infusion reactions which in some instances can be associated with acute liver injury. " D 5565 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CNCCNCCN)N Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of transient serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury with jaundice. Option B: It has not been associated with serum enzyme elevations during therapy or with cases of clinically apparent liver injury with jaundice, but its general use has been quite limited. Option C: It has been associated with rare instances of serum enzyme elevations during treatment, but has not been linked to cases of clinically apparent liver injury with jaundice. Option D: It has not been associated with worsening of serum enzyme elevations during therapy or with cases of clinically apparent liver injury with jaundice. " D 115237 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=O)N2CCCC(C2=N1)O)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent acute liver injury. Option B: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of clinically apparent acute liver injury. Option C: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of acute, clinically apparent liver injury. Option D: It is associated with a low rate of serum aminotransferase elevations during therapy and has not been linked to instances of clinically apparent acute liver injury. " B 54892 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2CC3=CC=CC=C3C[C@H]2C(=O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of transient serum aminotransferase elevations, but has yet to be linked to instances of acute liver injury. Option B: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of clinically apparent acute liver injury. Option C: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of acute, clinically apparent liver injury. Option D: It is associated with a low rate of serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent acute liver injury. " A 2564 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCOC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with instances of clinically apparent liver injury. Option B: It has not been linked to instances of clinically apparent acute liver injury. Option C: It has not been linked to instances of clinically apparent liver injury. Option D: It has not been linked to instances of clinically apparent, acute liver injury. " B 7843 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It can cause frostbite upon contact with the liquid. Option B: Contact with the liquid may cause frostbite by evaporative cooling. Option C: Contact with the liquid can cause frostbite. Option D: Contact with the liquid may cause frostbite. " C 4284 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)C(=O)C1=CC=CC(=C1)C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It was relatively safe and offered significant therapeutic benefits in cases of CML resistant to treatment with imatinib. Option B: Neither inhalant nor oral it has been linked to serum enzyme elevations during therapy or to convincing instances of clinically apparent acute liver injury. Option C: The amounts found in typical supplements has not been associated with serum enzyme elevations or with clinically apparent liver injury. Option D: Appropriate usage of the chemical at the recommended dosages and routes of administration have generally proven to be safe. " D 3080 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(CS)S)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of transient serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury with jaundice. Option B: It has not been associated with serum enzyme elevations during therapy or with cases of clinically apparent liver injury with jaundice, but its general use has been quite limited. Option C: It has not been associated with worsening of serum enzyme elevations during therapy or with cases of clinically apparent liver injury with jaundice. Option D: It has been associated with rare instances of serum enzyme elevations during treatment, but has not been linked to cases of clinically apparent liver injury with jaundice. " B 3883 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCC(F)(F)F Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with transient, asymptomatic serum aminotransferase elevations and is a suspected but rare cause of clinically apparent acute drug-induced liver injury. Option B: Therapy with this molecule is associated with a low rate of transient and asymptomatic serum aminotransferase elevations and is a reported, but very rare cause of clinically apparent liver injury. Option C: It is associated with a low rate of transient and mild serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent acute liver injury. Option D: It is associated with a low rate of transient and asymptomatic serum aminotransferase elevations during therapy, but has not been linked to instances of clinically apparent acute drug-induced liver injury. " B 4178 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=CC=C1)C)OCC(C)N Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Long term therapy is associated with a low rate of serum enzyme elevations and is a rare cause of clinically apparent acute liver injury. Option B: Long-term therapy is associated with a low rate of serum enzyme elevations and is a very rare cause of clinically apparent acute liver injury. Option C: It is associated with a low rate of transient and asymptomatic serum enzyme elevations and is a rare cause of clinically apparent acute liver injury. Option D: Long term therapy with this molecule is associated with a low rate of serum enzyme elevations and is a rare cause of clinically apparent acute liver injury. " A 896 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to either serum enzyme elevations or to clinically apparent acute liver injury. Option B: It has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury. Option C: It has not been implicated in causing serum enzyme elevations or clinically apparent liver injury. Option D: It has not been associated with serum enzyme elevations or clinically apparent liver injury. " C 37768 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1NC(=O)[C@H](CCN)O)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)N)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CN)O)O)O)N Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with instances of acute liver injury. Option B: It has not been associated with instances of clinically apparent liver injury. Option C: It has not been linked to instances of clinically apparent, acute liver injury. Option D: It has not been linked to instances of clinically apparent acute liver injury. " A 23668193 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: N(=O)[O-].[Na+] Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Exposure of the container to prolonged heat or fire can cause it to rupture violently and rocket. Option B: Prolonged exposure to fire or heat may cause violent rupturing and rocketing. Option C: Prolonged exposure to heat may result in an explosion. Option D: Exposure to prolonged heat or fire can cause it to rupture violently and rocket. " C 25183872 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: B([C@H](CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of serum enzyme elevations during treatment and to rare instances of clinically apparent, acute liver injury. Option B: It has been linked to a low rate of serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury. Option C: It has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. Option D: It has a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent acute liver injury. " A 996 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Exposure of the skin to concentrated phenol solutions causes chemical burns which may be severe. Option B: The FDA withdrew its approval for the use of this molecule gluconate topical tincture 0.5% due to a significant number of reports concerning chemical and thermal burns associated with the use of this product. Option C: It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when taken with CYP inhibitors or grapefruit juice. Option D: The potential of it to cause hepatotoxicity and the greater safety of newer anesthetics has led to a decrease in its use, currently limited to special situations, particularly in children. " A 3657 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(N)NO Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of transient serum enzyme and bilirubin elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury with jaundice. Option B: It is associated with a low rate of transient serum enzyme and bilirubin elevations during therapy, and has been implicated in rare cases of clinically apparent acute liver injury with jaundice. Option C: It is associated with a low rate of transient serum enzyme elevations during therapy and has only rarely been implicated in cases of clinically apparent acute liver injury with jaundice. Option D: It is associated with a low rate of transient serum enzyme and bilirubin elevations during therapy, but has only rarely been implicated in cases of clinically apparent acute liver injury with jaundice. " B 23978 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Cu] Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with serum enzyme elevations during therapy or with clinically apparent liver injury. Option B: It has not been associated with serum enzyme elevations during therapy or with published instances of clinically apparent liver injury. Option C: The amounts found in typical supplements has not been associated with serum enzyme elevations or with clinically apparent liver injury. Option D: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. " C 154234 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(CC)[C@@H]([C@H]1[C@@H](C[C@@H]([C@H]1O)C(=O)O)N=C(N)N)NC(=O)C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with serum enzyme elevations during therapy or with published instances of clinically apparent liver injury. Option B: It has not been found to be associated with serum enzyme elevations during therapy or to instances of clinically apparent liver injury. Option C: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option D: It has not been associated with serum enzyme elevations during therapy or with clinically apparent liver injury. " D 27125 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1[C@H]([C@H]([C@@H]2O)O)O)CCC4=C3C=CC(=C4)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It was not linked to instances of acute liver injury during therapy but, when combined with peginterferon and ribavirin, was associated with cases of hepatic decompensation in patients with preexisting cirrhosis. Option B: It is more potent and is safer than the synthetic estrogen ethinylestradiol (EE2) found in 97% of oral contraceptive pills, reducing the environmental accumulation of unwanted endocrine disrupting chemicals (EDCs) that often lead to harmful epigenetic effects. Option C: It has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury, but the combination with acetaminophen has been linked to many cases of acute liver failure due to unintentional overdose with acetaminophen. Option D: It is frequently associated with serum enzyme elevations, but more importantly, it has been linked to rapid onset, severe hypersensitivity reactions that can be associated with acute hepatic necrosis, liver failure, and death. " B 129211 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC1=CC=CC=C1OCCN[C@H](C)CC2=CC(=C(C=C2)OC)S(=O)(=O)N Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Therapy is associated with a low rate of serum aminotransferase elevations, but clinically apparent acute liver injury due to it is very rare. Option B: It is associated with a low rate of serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent acute liver injury. Option C: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of acute, clinically apparent liver injury. Option D: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of clinically apparent acute liver injury. " A 3314 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C=CC(=C1)CC=C)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Eugenol in therapeutic doses has not been implicated in causing serum enzyme elevations or clinically apparent liver injury, but ingestions of high doses, as with an overdose, can cause severe liver injury. Option B: Therapy with this molecule has been associated with a low rate of serum enzyme elevations, but has not been linked to cases of clinically apparent acute liver injury, although it can cause severe hypersensitivity infusion reactions which in some instances can be associated with acute liver injury. Option C: It is frequently associated with serum enzyme elevations, but more importantly, it has been linked to rapid onset, severe hypersensitivity reactions that can be associated with acute hepatic necrosis, liver failure, and death. Option D: It is associated with a modest rate of minor serum enzyme elevations during therapy, but it has not been linked to cases of clinically apparent liver injury. However, it has been reported to cause reactivation of hepatitis B. " A 464205 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](CN1C=NC2=C(N=CN=C21)N)OCP(=O)(O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to instances of clinically apparent drug induced liver injury. Option B: It does not appear to be a significant cause of drug-induced liver injury. Option C: It has not been associated with instances of clinically apparent liver injury. Option D: It has not been linked to instances of clinically apparent drug-induced liver injury. " B 1030 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CO)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is generally considered safe. Option B: It has rarely been linked to instances of clinically apparent liver injury. Option C: The pure compound is a dangerous explosive, particularly when dry. Option D: It is generally considered safe by the FDA. " A 25102847 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has been implicated with rare instances of clinically apparent, acute liver injury, some of which have been severe. Option B: It has only rarely been implicated in cases of clinically apparent, acute liver injury. Option C: It has been implicated in causing rare instances of clinically apparent liver injury which can be severe. Option D: It has been associated with rare instances of clinically apparent, acute liver injury. " A 4679 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C(=NC=C1)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC(F)F)OC Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is a rare cause of clinically apparent liver injury. Option B: It has been linked to rare cases of clinically apparent acute liver injury. Option C: It has rarely been linked to instances of clinically apparent liver injury. Option D: It has been linked to rare instances of clinically apparent acute liver injury. " A 16078 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC1=CC(=C2[C@@H]3C=C(CC[C@H]3C(OC2=C1)(C)C)C)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been convincingly linked to cases of clinically apparent liver injury. Option B: It has not been linked to cases of clinically apparent liver injury. Option C: It has not been clearly linked to cases of clinically apparent liver injury with jaundice. Option D: It has not been linked to cases of clinically apparent liver injury with jaundice. " D 4021 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NN(C(=O)C1)C2=CC=CC=C2 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to instances of clinically apparent liver injury. Option B: It has not been associated with instances of clinically apparent liver injury. Option C: It has not been linked to instances of clinically apparent, acute liver injury. Option D: It has not been linked to instances of clinically apparent acute liver injury. " C 443879 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=C(C=C1)O)[C@H](CCN(C(C)C)C(C)C)C2=CC=CC=C2 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury. Option B: It has not been associated with serum enzyme elevations or clinically apparent liver injury. Option C: It has not been implicated in causing serum enzyme elevations or clinically apparent liver injury. Option D: It has not been linked to either serum enzyme elevations or to clinically apparent acute liver injury. " A 2576 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(C)(COC(=O)N)COC(=O)NC(C)C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with liver test abnormalities or with clinically apparent hepatotoxicity. Option B: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option C: It has no significant evidence for causing hepatic injury. Option D: It has not been associated with serum enzyme elevations or with instances of clinically apparent liver injury with jaundice. " C 4497 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOC Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been implicated in causing clinically apparent acute liver injury. Option B: It has not been implicated as a cause of clinically apparent liver injury. Option C: It has not been linked to instances of clinically apparent acute liver injury. Option D: It has not been linked to instances of clinically apparent, acute liver injury. " A 71158 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)NCCCS(=O)(=O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option B: It has not been linked to serum enzyme elevations during therapy or to cases of clinically apparent liver injury. Option C: It has not been found to be associated with serum enzyme elevations during therapy or to instances of clinically apparent liver injury. Option D: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent liver injury. " B 444031 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(C[C@@H]1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to either serum enzyme elevations or to clinically apparent acute liver injury. Option B: It has not been implicated in causing serum enzyme elevations or clinically apparent liver injury. Option C: It has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury. Option D: It has not been associated with serum enzyme elevations or clinically apparent liver injury. " C 1349907 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C=CNC1=S Question about this molecule: What is the right information about this molecule's safety concerns? Option A: The FDA withdrew its approval for the use of this molecule gluconate topical tincture 0.5% due to a significant number of reports concerning chemical and thermal burns associated with the use of this product. Option B: It is preferred over propylthiouracil due to the risk of fulminant hepatotoxicity carried by the latter. Option C: It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when taken with CYP inhibitors or grapefruit juice. Option D: The potential of it to cause hepatotoxicity and the greater safety of newer anesthetics has led to a decrease in its use, currently limited to special situations, particularly in children. " B 446987 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@H](O1)P(=O)(O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has been linked to rare instances of clinically apparent liver injury with jaundice. Option B: It has been associated with rare instances of clinically apparent, acute liver injury. Option C: It has been linked to rare cases of clinically apparent acute liver injury. Option D: It is associated with rare cases of clinically apparent acute liver injury with jaundice. " D 5284569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3C(=O)CC4 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is frequently associated with serum enzyme elevations, but more importantly, it has been linked to rapid onset, severe hypersensitivity reactions that can be associated with acute hepatic necrosis, liver failure, and death. Option B: It has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury, but the combination with acetaminophen has been linked to many cases of acute liver failure due to unintentional overdose with acetaminophen. Option C: It was not linked to instances of acute liver injury during therapy but, when combined with peginterferon and ribavirin, was associated with cases of hepatic decompensation in patients with preexisting cirrhosis. Option D: It is more potent and is safer than the synthetic estrogen ethinylestradiol (EE2) found in 97% of oral contraceptive pills, reducing the environmental accumulation of unwanted endocrine disrupting chemicals (EDCs) that often lead to harmful epigenetic effects. " B 7029 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)C(C)C(=O)C1=CC=CC=C1 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to significant serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. Option B: It has not been linked to either serum enzyme elevations or to clinically apparent acute liver injury. Option C: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. Option D: It has not been linked to serum enzyme elevations or to instances of clinically apparent acute liver injury. " B 24502 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-][Cr](=O)(=O)O[Cr](=O)(=O)[O-].[K+].[K+] Question about this molecule: What is the right information about this molecule's safety concerns? Option A: The pure compound is a dangerous explosive, particularly when dry. Option B: Avoid contact with organic materials. Option C: It is generally considered safe by the FDA. Option D: It is generally considered safe. " B 13505 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C1(CCN(CC1)CCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury. Option B: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent liver injury. Option C: It has not been found to be associated with serum enzyme elevations during therapy or to instances of clinically apparent liver injury. Option D: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. " A 135436526 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C(=N)N[N+](=O)[O-])N=O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: The amounts found in typical supplements has not been associated with serum enzyme elevations or with clinically apparent liver injury. Option B: No significant increase in cancer mortality was observed in workers occupationally exposed to it by inhalation. Option C: Neither inhalant nor oral it has been linked to serum enzyme elevations during therapy or to convincing instances of clinically apparent acute liver injury. Option D: Avoid skin contact and inhalation of vapors. " D 135398513 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC2=C(N1COCCO)N=C(NC2=O)N Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with instances of clinically apparent liver injury. Option B: It has not been associated with clinically apparent liver injury. Option C: It has not been linked to instances of clinically apparent liver injury. Option D: It has not been linked to episodes of clinically apparent liver injury. " B 6432 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(F)(F)F)(C(F)(F)F)(F)F Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Exposure of the container to prolonged heat or fire can cause it to rupture violently and rocket. Option B: It may rupture violently and rocket when exposed to prolonged heat or fire. Option C: Prolonged exposure to fire or heat may cause violent rupturing and rocketing. Option D: Exposure to prolonged heat or fire can cause it to rupture violently and rocket. " A 3446 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(CC1)(CC(=O)O)CN Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Therapy is associated with a low rate of serum aminotransferase elevations, but clinically apparent acute liver injury due to it is very rare. Option B: Therapy with it is not associated with serum aminotransferase elevations, and cases of clinically apparent liver injury from it have been reported but are very rare. Option C: It is not associated with serum aminotransferase elevations, but several cases of clinically apparent liver injury from it have been reported. Option D: It is associated with transient and usually mild elevations in serum aminotransferase during therapy, but has not been convincingly linked to cases of clinically apparent liver injury. " C 54841 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1O[C@H](CCNC)C2=CC=CC=C2 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of serum aminotransferase elevations during therapy and with rare instances of clinically apparent, acute liver injury. Option B: It has a low rate of serum aminotransferase elevations and rare cases of acute, clinically apparent liver injury. Option C: It has been linked to a low rate of serum aminotransferase elevations during therapy and to rare instances of clinically apparent liver injury. Option D: It has a low rate of serum aminotransferase elevations during therapy and has not been linked to instances of clinically apparent acute liver injury. " B 33741 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C[C@H]1CCCC[C@@]1(C2=CC(=CC=C2)OC)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Mesalamine therapy has been associated with a low rate of serum enzyme elevations during therapy and with rare instances of clinically apparent acute liver injury. Option B: Pharmacologic doses of it have not been associated with cases of clinically apparent drug-induced liver disease. Option C: Chronic therapy with this molecule has not been associated with serum enzyme elevations, but has been linked to rare cases of mild, clinically apparent liver injury. Option D: Therapy with it has been associated with a low rate of serum enzyme elevations, but has not been clearly linked to cases of clinically apparent acute liver injury. " B 3955 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option B: It has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury. Option C: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent liver injury. Option D: It has not been found to be associated with serum enzyme elevations during therapy or to instances of clinically apparent liver injury. " B 3342 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C1=CC(=CC=C1)OC2=CC=CC=C2)C(=O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. Option B: It has a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent acute liver injury. Option C: It has a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. Option D: It has been linked to a low rate of serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury. " B 2812 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Therapy with this molecule is associated with a low rate of transient and asymptomatic serum aminotransferase elevations and is a reported, but very rare cause of clinically apparent liver injury. Option B: It is associated with a low rate of transient and mild serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent acute liver injury. Option C: It is associated with a low rate of transient and asymptomatic serum aminotransferase elevations during therapy, but has not been linked to instances of clinically apparent acute drug-induced liver injury. Option D: It has been associated with transient and asymptomatic serum aminotransferase elevations during therapy when given orally or as troches, but it has not been linked to instances of clinically apparent acute liver injury. " D 3083544 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](CC1=CC=C(C=C1)OC)NC[C@@H](C2=CC(=C(C=C2)O)NC=O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is frequently associated with serum enzyme elevations, but more importantly, it has been linked to rapid onset, severe hypersensitivity reactions that can be associated with acute hepatic necrosis, liver failure, and death. Option B: Therapy with this molecule has been associated with a low rate of serum enzyme elevations, but has not been linked to cases of clinically apparent acute liver injury, although it can cause severe hypersensitivity infusion reactions which in some instances can be associated with acute liver injury. Option C: Eugenol in therapeutic doses has not been implicated in causing serum enzyme elevations or clinically apparent liver injury, but ingestions of high doses, as with an overdose, can cause severe liver injury. Option D: The use of it is pending revision due to safety concerns in regards to an increased risk of severe exacerbation of asthma symptoms, leading to hospitalization as well as death in some patients using long-acting beta agonists for the treatment of asthma. " D 5206 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(OC(C(F)(F)F)C(F)(F)F)F Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is generally considered safe. Option B: The pure compound is a dangerous explosive, particularly when dry. Option C: It has an excellent safety record. Option D: It is generally considered safe by the FDA. " C 31101 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]3(N1C(=O)[C@](O3)(C(C)C)NC(=O)[C@H]4CN([C@@H]5CC6=C(NC7=CC=CC(=C67)C5=C4)Br)C)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of serum enzyme elevations during treatment and has been implicated in rare instances of clinically apparent, acute liver injury. Option B: It is associated with a low rate of transient serum enzyme elevations during treatment and has been implicated in rare cases of acute liver injury. Option C: It is associated with a low rate of serum enzyme elevations during treatment and to rare instances of clinically apparent, acute liver injury. Option D: It therapy is associated with low rate of transient serum enzyme elevations during treatment and has been implicated in rare cases of acute liver injury. " D 4075 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1N)C(=O)O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a minimal rate of serum enzyme elevations during therapy and has only rarely been implicated as a cause of clinically apparent acute liver injury. Option B: It is associated with a low rate of serum enzyme elevations during treatment and has been implicated in rare instances of clinically apparent, acute liver injury. Option C: Mesalamine therapy has been associated with a low rate of serum enzyme elevations during therapy and with rare instances of clinically apparent acute liver injury. Option D: It is associated with a minimal rate of serum enzyme elevations during therapy and has only rarely been implicated as a cause of clinically apparent liver injury. " C 6253 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of transient serum enzyme elevations during therapy and has only rarely been implicated in cases of clinically apparent acute liver injury with jaundice. Option B: It is associated with a low rate of transient serum enzyme and bilirubin elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury with jaundice. Option C: It is associated with a low rate of transient serum enzyme and bilirubin elevations during therapy, but has only rarely been implicated in cases of clinically apparent acute liver injury with jaundice. Option D: It is associated with a low rate of transient serum enzyme and bilirubin elevations during therapy, and has been implicated in rare cases of clinically apparent acute liver injury with jaundice. " C 11154555 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C(=O)NC1CCC(CC1)CCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent acute liver injury. Option B: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of clinically apparent acute liver injury. Option C: It has been associated with a low rate of serum aminotransferase elevations during therapy, but it has not been linked to instances of clinically apparent acute liver injury. Option D: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of acute, clinically apparent liver injury. " C 6327 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCl Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Contact with the unconfined liquid may cause frostbite by evaporative cooling. Option B: Contact with the unconfined liquid can cause frostbite by evaporative cooling and chemical type burns. Option C: Contact with the liquid may cause frostbite. Option D: Contact with the liquid may cause frostbite by evaporative cooling. " D 300 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)O)Cl Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It can cause thermal burns. Option B: It may cause burns. Option C: It has rarely been linked to instances of clinically apparent liver injury. Option D: Contact with the liquid causes painful burns. " A 33557 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N-]=[N+]=[N-].[Na+] Question about this molecule: What is the right information about this molecule's safety concerns? Option A: The pure compound is a dangerous explosive, particularly when dry. Option B: It may explode if large quantities are involved. Option C: It is generally considered safe by the FDA. Option D: It is generally considered safe. " B 6351 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC1 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Contact with the liquid may cause frostbite by evaporative cooling. Option B: Contact with the liquid can cause frostbite. Option C: Contact with the liquid may cause frostbite. Option D: It can cause frostbite upon contact with the liquid. " C 2973 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCN)O)O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with serum aminotransferase elevations during therapy or episodes of acute, clinically apparent liver injury. Option B: It rarely causes serum aminotransferase elevations during therapy and has not been convincingly linked to instances of clinically apparent liver injury. Option C: It has not been linked to serum aminotransferase elevations during therapy nor to instances of clinically apparent liver injury. Option D: It has not been associated with serum aminotransferase elevations during therapy or instances of clinically apparent acute liver injury. " B 3354 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(OC2=C(C1=O)C=CC=C2C(=O)OCCN3CCCCC3)C4=CC=CC=C4 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with serum enzyme elevations or clinically apparent liver injury. Option B: It has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury. Option C: It has not been linked to either serum enzyme elevations or to clinically apparent acute liver injury. Option D: It has not been implicated in causing serum enzyme elevations or clinically apparent liver injury. " B 5388906 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CC[C@@](C1=CC=CC2=CC=CC=C21)([C@H](C3=CC=CC=C3)C4=C(N=C5C=CC(=CC5=C4)Br)OC)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of transient serum enzyme and bilirubin elevations during therapy, but has only rarely been implicated in cases of clinically apparent acute liver injury with jaundice. Option B: The addition of it to antituberculosis drug regimens has been linked to an increased rate of transient serum liver test abnormalities during treatment and to several instances of clinically apparent liver injury. Option C: It has been associated with a low rate of serum enzyme elevations during treatment, but has yet to be implicated in cases of clinically apparent acute liver injury with jaundice. Option D: It is associated with a low rate of transient serum enzyme and bilirubin elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury with jaundice. " B 6533629 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CO/N=C(/C1=CSC(=N1)N)\\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=CCS3)C(=O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders. Option B: It has not been associated with worsening of serum enzyme elevations during therapy or with cases of clinically apparent liver injury with jaundice. Option C: It has not been associated with serum enzyme elevations during therapy or with cases of clinically apparent liver injury with jaundice, but its general use has been quite limited. Option D: It has been associated with rare instances of serum enzyme elevations during treatment, but has not been linked to cases of clinically apparent liver injury with jaundice. " A 1118 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OS(=O)(=O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with serum enzyme elevations during therapy or with published instances of clinically apparent liver injury. Option B: The amounts found in typical supplements has not been associated with serum enzyme elevations or with clinically apparent liver injury. Option C: Sometimes, it is dyed dark brown during production to alert people to its hazards. Option D: It is highly toxic to aquatic life, particularly fish, and therefore must be used with extreme caution around water. " C 5472 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(CC2=C1SC=C2)CC3=CC=CC=C3Cl Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to serum enzyme elevations during therapy and is an exceedingly rare cause of idiosyncratic clinically apparent acute liver injury. Option B: It has not been associated with serum enzyme elevations during treatment and has not been linked to cases of clinically apparent acute liver injury. Option C: It has been linked to rare instances of idiosyncratic, clinically apparent acute liver injury. Option D: It has not been associated with serum enzyme elevations during therapy or instances of idiosyncratic acute liver injury. " C 1983 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)NC1=CC=C(C=C1)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is important to follow current and available national and manufacturer dosing guidelines while this drug is taken or prescribed. Option B: It is highly toxic to aquatic life, particularly fish, and therefore must be used with extreme caution around water. Option C: It has not been associated with serum enzyme elevations during therapy or with published instances of clinically apparent liver injury. Option D: The amounts found in typical supplements has not been associated with serum enzyme elevations or with clinically apparent liver injury. " A 5029 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCCCOC Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has rarely been linked to instances of clinically apparent liver injury. Option B: It has been linked to rare cases of clinically apparent acute liver injury. Option C: It is a rare cause of clinically apparent liver injury. Option D: It has been linked to rare instances of clinically apparent acute liver injury. " C 3893 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCC(=O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is non-toxic and safe to handle. Option B: It is noncombustible and nontoxic. Option C: It is generally considered safe by the FDA. Option D: It is generally considered safe. " A 9854012 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CSCCNC1=C2C(=NC(=N1)SCCC(F)(F)F)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has been linked to rare instances of clinically apparent acute liver injury. Option B: It has rarely been linked to instances of clinically apparent liver injury. Option C: It has been linked to rare cases of clinically apparent acute liver injury. Option D: Its clinical use has been limited. " D 33624 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)NC[C@@H](COC1=NSN=C1N2CCOCC2)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked convincingly to cases of clinically apparent acute liver injury. Option B: It has yet to be implicated in cases of clinically apparent acute liver injury. Option C: It has yet to be linked to instances of clinically apparent acute liver injury. Option D: It has yet to be convincingly associated with clinically apparent liver injury. " D 3052776 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C#CCN[C@@H]1CCC2=CC=CC=C12 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to instances of clinically apparent, acute liver injury. Option B: It has not been linked to instances of clinically apparent acute liver injury. Option C: It has not been associated with instances of clinically apparent liver injury. Option D: It has not been linked to instances of clinically apparent liver injury. " B 971 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(=O)O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is a rare cause of clinically apparent liver injury. Option B: It is considered a mild toxin. Option C: It has been linked to rare instances of clinically apparent acute liver injury. Option D: It has rarely been linked to instances of clinically apparent liver injury. " B 2405 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to instances of clinically apparent drug induced liver injury. Option B: It has not been associated with instances of clinically apparent liver injury. Option C: It has not been linked to instances of clinically apparent drug-induced liver injury. Option D: It has not been linked to episodes of clinically apparent liver injury. " A 3324 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)OCC(CCN1C=NC2=CN=C(N=C21)N)COC(=O)C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with clinically apparent liver injury. Option B: It has not been linked to instances of clinically apparent liver injury. Option C: It has not been associated with instances of clinically apparent liver injury. Option D: It has not been linked to episodes of clinically apparent liver injury. " C 135413536 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NNC(=O)N3)C4=CC=C(C=C4)F Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to cases of clinically apparent liver injury with jaundice. Option B: It has not been linked to cases of clinically apparent liver injury. Option C: It has not been clearly linked to cases of clinically apparent liver injury with jaundice. Option D: It has not been convincingly linked to cases of clinically apparent liver injury. " C 3393 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3F Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Clinically apparent liver injury from it has not been reported and must be rare if it occurs at all. Option B: It has not been associated with serum enzyme elevations during therapy or with published instances of clinically apparent liver injury. Option C: Clinically apparent drug induced liver disease has been reported with its use but is very rare. Option D: Clinically apparent liver injury from this molecule has been reported, but is very rare. " D 2802 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3Cl Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with serum enzyme elevations during treatment and must be a very rare cause of clinically apparent acute liver injury, if it occurs at all. Option B: Clinically apparent liver injury from it has not been reported and must be rare if it occurs at all. Option C: Clinically apparent liver injury from clonazepam, if it occurs at all, must be exceedingly rare. Option D: Therapy with it has not been associated with serum aminotransferase elevations, and clinically apparent liver injury from it has yet to be reported and must be rare, if it occurs at all. " C 135398508 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=C1[C@H](C[C@@H]([C@H]1CO)O)N2C=NC3=C2N=C(NC3=O)N Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with instances of clinically apparent liver injury. Option B: It has not been linked to episodes of clinically apparent liver injury. Option C: It has not been linked to instances of clinically apparent liver injury. Option D: It has not been linked to cases of clinically apparent liver injury. " D 125468 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C=C(\\C)/C(=O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has been linked to rare instances of clinically apparent acute liver injury. Option B: It has been linked to rare instances of clinically apparent liver injury with jaundice. Option C: May burn if heated to high temperatures. Option D: It will burn only when it reaches very high temperatures. " C 281 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C-]#[O+] Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It does not pose a risk if food is maintained adequately cold during storage and transport to prevent the growth of microorganisms. Option B: It is associated with a low rate of serum enzyme elevation during therapy, but it has not been linked to cases of clinically apparent liver injury with jaundice. Option C: Its use is associated with a low rate of serum enzyme elevation, but it has not been linked to cases of clinically apparent liver injury with jaundice. Option D: Use of it is associated with a low rate of serum enzyme elevations during therapy but it has not been linked to instances of clinically apparent acute liver injury. " A 121892 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)NC1=C(C=C(C=C1)NCC2=CC=C(C=C2)F)N Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with serum aminotransferase elevations nor with clinically apparent liver injury. Option B: It has not been associated with serum aminotransferase elevations during therapy or instances of clinically apparent acute liver injury. Option C: It has not been linked to serum aminotransferase elevations during therapy nor to instances of clinically apparent liver injury. Option D: It has not been associated with serum aminotransferase elevations and clinically apparent liver injury. " D 222 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: N Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It may rupture violently and rocket when exposed to prolonged heat or fire. Option B: Exposure of the container to prolonged heat or fire can cause it to rupture violently and rocket. Option C: Prolonged exposure to fire or heat may cause violent rupturing and rocketing. Option D: Exposure to prolonged heat or fire can cause it to rupture violently and rocket. " C 3291 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC1(CC(=O)NC1=O)C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with serum enzyme elevations during therapy or with cases of clinically apparent liver injury with jaundice, but its general use has been quite limited. Option B: It has been associated with rare instances of serum enzyme elevations during treatment, but has not been linked to cases of clinically apparent liver injury with jaundice. Option C: It has not been associated with worsening of serum enzyme elevations during therapy or with cases of clinically apparent liver injury with jaundice. Option D: It is associated with a low rate of transient serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury with jaundice. " B 4485 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of serum enzyme elevations and has been linked to several instances of clinically apparent acute liver injury. Option B: It has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. Option C: It has a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent acute liver injury. Option D: It has been linked to a low rate of serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury. " A 5284514 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)/C(=C\\CN2CCCC2)/C3=CC=CC(=N3)/C=C/C(=O)O Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with instances of clinically apparent liver injury. Option B: It has not been linked to instances of clinically apparent, acute liver injury. Option C: It has not been linked to instances of clinically apparent liver injury. Option D: It has not been linked to instances of clinically apparent acute liver injury. " D 2682 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCCCCCO Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a minimal rate of serum enzyme elevations during therapy and is a rare cause of clinically apparent liver injury. Option B: It is a safe synthetic fatty acid in food and in the synthesis of food components under specific conditions. Option C: It has a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. Option D: It has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. " B 24014 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: Cl[Cu]Cl Question about this molecule: What is the right information about this molecule's safety concerns? Option A: Contact with the unconfined liquid may cause frostbite by evaporative cooling. Option B: It is noncombustible but may form hydrogen chloride gas when heated in a fire. Option C: It is noncombustible, but may decompose to emit toxic oxide fumes of sulfur and sodium when heated to high temperature. Option D: Contact with the unconfined liquid can cause frostbite by evaporative cooling and chemical type burns. " B 182137 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN[C@@]1(CCCCC1=O)C2=CC=CC=C2Cl Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to significant serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. Option B: It has not been associated with serum enzyme elevations during treatment nor to instances of clinically apparent acute liver injury. Option C: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent liver injury. Option D: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. " B 77991 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(C)C(=O)OC1=CC=CC(=C1)[C@H](C)N(C)C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. Option B: It has a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. Option C: It is associated with a minimal rate of serum enzyme elevations during therapy and is a rare cause of clinically apparent liver injury. Option D: It has a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent acute liver injury. " C 5625 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NC1=C(N=CC=C1)N2CCN(CC2)C(=O)C3=CC4=C(N3)C=CC(=C4)NS(=O)(=O)C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It is associated with a low rate of transient serum aminotransferase elevations during therapy and is a rare cause of clinically apparent acute liver injury. Option B: It is associated with a low rate of serum aminotransferase elevations during therapy and with rare instances of clinically apparent, acute liver injury. Option C: It is associated with a low rate of serum aminotransferase elevations during therapy and has not been linked to instances of clinically apparent acute liver injury. Option D: It has a low rate of serum aminotransferase elevations during therapy and has not been linked to instances of clinically apparent acute liver injury. " A 7346 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C(=O)OC(=O)C(C)C Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has been linked to rare instances of clinically apparent liver injury with jaundice. Option B: It may burn skin, eyes, and mucous membranes. Option C: It burns skin and eyes. Option D: It burns skin, eyes, and mucous membranes. " C 3100 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to instances of clinically apparent acute liver injury. Option B: It has not been linked to instances of clinically apparent liver injury. Option C: It has not been associated with instances of clinically apparent liver injury. Option D: It has not been linked to instances of clinically apparent, acute liver injury. " A 3455 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been associated with instances of clinically apparent liver injury. Option B: It has at least moderate potential to be abused by humans. Option C: It has not been associated with clinically apparent liver injury. Option D: It has not been shown to cause clinically apparent liver injury. " B 5282443 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)/C(=C\\CN2CCCC2)/C3=CC=CC=N3 Question about this molecule: What is the right information about this molecule's safety concerns? Option A: It has not been linked to instances of clinically apparent liver injury. Option B: It has not been linked to instances of clinically apparent acute liver injury. Option C: It has not been linked to instances of clinically apparent, acute liver injury. Option D: It has not been associated with instances of clinically apparent liver injury. " B 54960 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC(=NC(=N1)NC(=O)NS(=O)(=O)CC2=CC=CC=C2C(=O)OC)OC Question about this molecule: Which kind of selectivity does this molecule have/exhibit? Option A: It exerts the highest degree of selectivity for the serotonin transporter (SERT). Option B: It has higher selectivity toward the alpha-2 adrenergic receptors. Option C: It has selectivity for muscarinic receptors in the lungs. Option D: It has selectivity for inhibiting biosynthesis of valine and isoleucine. " D 10311306 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC[C@]2(CC[C@]3(CCC(=O)N3)CN2)C4=CC=CC=C4 Question about this molecule: Which kind of selectivity does this molecule have/exhibit? Option A: It has selectivity for inhibiting biosynthesis of valine and isoleucine. Option B: It has selectivity for muscarinic receptors in the lungs. Option C: It has selectivity for Neurokinin-1 (NK-1) receptors. Option D: It has higher selectivity toward the alpha-2 adrenergic receptors. " C 3325 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(N=C(S1)N=C(N)N)CSCCC(=NS(=O)(=O)N)N Question about this molecule: Which kind of selectivity does this molecule have/exhibit? Option A: It has selectivity for estrogen receptor beta (ERβ). Option B: It has selectivity for beta2 receptors. Option C: It has selectivity for the H1 receptor. Option D: It has selectivity for the H2 receptor. " D 2083 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)NCC(C1=CC(=C(C=C1)O)CO)O Question about this molecule: Which kind of selectivity does this molecule have/exhibit? Option A: It has selectivity for estrogen receptor beta (ERβ). Option B: It has selectivity for beta2 receptors. Option C: It has selectivity for the H2 receptor. Option D: It has selectivity for the H1 receptor. " B 115224 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CSC(=NC#N)N1CC2=CN=C(C=C2)Cl Question about this molecule: Which kind of selectivity does this molecule have/exhibit? Option A: It has selectivity for If channels. Option B: It has selectivity for insects over mammals. Option C: It has selectivity for peripheral blood vessels. Option D: It has selectivity for peripheral opioid receptors. " B 114829 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@H](OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)O Question about this molecule: Which kind of selectivity does this molecule have/exhibit? Option A: It has selectivity for beta2 receptors. Option B: It has selectivity for estrogen receptor beta (ERβ). Option C: It has selectivity for the H2 receptor. Option D: It has selectivity for peripheral opioid receptors. " B 5487427 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+]1([C@@H]2CC(C[C@H]1[C@H]3[C@@H]2O3)OC(=O)C(C4=CC=CS4)(C5=CC=CS5)O)C Question about this molecule: Which kind of selectivity does this molecule have/exhibit? Option A: It has higher selectivity toward the alpha-2 adrenergic receptors. Option B: It has selectivity for muscarinic receptors in the lungs. Option C: It has selectivity for SGLT2 over SGLT1. Option D: It has selectivity for inhibiting biosynthesis of valine and isoleucine. " B 2162 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN Question about this molecule: Which kind of selectivity does this molecule have/exhibit? Option A: It has selectivity for peripheral blood vessels. Option B: It has selectivity for estrogen receptor beta (ERβ). Option C: It has selectivity for beta2 receptors. Option D: It has selectivity for peripheral opioid receptors. " A 2481 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CC1(C(=O)NC(=O)NC1=O)CC=C Question about this molecule: Which kind of selectivity does this molecule have/exhibit? Option A: It has no selectivity. Option B: It has greater selectivity. Option C: It has good selectivity. Option D: It has selectivity for If channels. " A 4409 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)CCC1=CC2=C(C=C1)C=C(C=C2)OC Question about this molecule: Which kind of selectivity does this molecule have/exhibit? Option A: It has selectivity for If channels. Option B: It has no selectivity. Option C: It has good selectivity. Option D: It has greater selectivity. " B 213021 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=NC#N)N(C)CC1=CN=C(C=C1)Cl Question about this molecule: Which kind of selectivity does this molecule have/exhibit? Option A: It has selectivity for peripheral blood vessels. Option B: It has selectivity for insects over mammals. Option C: It has selectivity for peripheral opioid receptors. Option D: It has selectivity for If channels. " B 129211 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC1=CC=CC=C1OCCN[C@H](C)CC2=CC(=C(C=C2)OC)S(=O)(=O)N Question about this molecule: Which kind of selectivity does this molecule have/exhibit? Option A: It has good selectivity. Option B: It has greater selectivity. Option C: It has no selectivity. Option D: It has selectivity for If channels. " C 10531 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@]1(C(=O)N2[C@H](C(=O)N3CCC[C@H]3[C@@]2(O1)O)CC4=CC=CC=C4)NC(=O)[C@@H]5C[C@H]6[C@@H](CC7=CNC8=CC=CC6=C78)N(C5)C Question about this molecule: Which kind of selectivity does this molecule have/exhibit? Option A: It has greater selectivity. Option B: It has no selectivity. Option C: It has selectivity for If channels. Option D: It has good selectivity. " A 4497 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOC Question about this molecule: Which kind of selectivity does this molecule have/exhibit? Option A: It has greater selectivity for PDE5. Option B: It has greater effects on cerebral circulation. Option C: It has greater selectivity. Option D: It has good selectivity. " B 135398748 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC2=C(N1CCC(CO)CO)N=C(NC2=O)N Question about this molecule: Which kind of selectivity does this molecule have/exhibit? Option A: It has greater selectivity. Option B: It has good selectivity. Option C: It has selectivity for If channels. Option D: It has no selectivity. " B 2249 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(COC1=CC=C(C=C1)CC(=O)N)O Question about this molecule: Which kind of selectivity does this molecule have/exhibit? Option A: It has good selectivity. Option B: It has greater selectivity. Option C: It has cardioselective properties. Option D: It is non-selective. " C 86222 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C(CC1=CC(=C(C=C1Cl)F)N2C(=O)N(C(=N2)C)C(F)F)Cl Question about this molecule: Which kind of selectivity does this molecule have/exhibit? Option A: It has greater selectivity. Option B: It is non-selective. Option C: It has cardioselective properties. Option D: It has good selectivity. " B 41428 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=NC(=C1Cl)Cl)OCC(=O)O)Cl Question about this molecule: Which kind of selectivity does this molecule have/exhibit? Option A: It has selectivity for muscarinic receptors in the lungs. Option B: It has selectivity for inhibiting biosynthesis of valine and isoleucine. Option C: It has selectivity for broadleaf weeds. Option D: It has higher selectivity toward the alpha-2 adrenergic receptors. " C 146570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCC[C@@]1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F Question about this molecule: Which kind of selectivity does this molecule have/exhibit? Option A: It exerts the highest degree of selectivity for the serotonin transporter (SERT). Option B: It has selectivity for inhibiting biosynthesis of valine and isoleucine. Option C: It has selectivity for muscarinic receptors in the lungs. Option D: It has higher selectivity toward the alpha-2 adrenergic receptors. " A 2405 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O Question about this molecule: Which kind of selectivity does this molecule have/exhibit? Option A: It has selectivity for Neurokinin-1 (NK-1) receptors. Option B: It has higher selectivity toward the alpha-2 adrenergic receptors. Option C: It has β1-adrenergic receptor selectivity. Option D: It has selectivity for muscarinic receptors in the lungs. " C 5281873 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C(C1C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)/C=C(/C(F)(F)F)\\Cl)C Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It is especially sensitive to shock and heat. Option B: It can harm sensitive individuals. Option C: It is a sensitive high explosive. Option D: It becomes shock sensitive. " B 637511 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)/C=C/C=O Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: The C=S bond is insensitive to the nature of the substitutent. Option B: It is insensitive to this molecule treatment. Option C: It can be identified with a clinical patch test. Option D: Sensitivity to this molecule can be identified with a clinical patch test. " C 6954 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1[N+](=O)[O-])O)[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It becomes shock sensitive. Option B: It is sensitive to light. Option C: It is a sensitive high explosive. Option D: It is especially sensitive to shock and heat. " C 12967 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(C(=O)N)N=O Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It may be sensitive to prolonged exposure to light. Option B: It is sensitive to air and light. Option C: It is especially sensitive to shock and heat. Option D: It is sensitive to light. " D 40585 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1([C@H]([C@H]1C(=O)O[C@H](C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C=C(Br)Br)C Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It is a sensitive high explosive. Option B: It can harm sensitive individuals. Option C: It becomes shock sensitive. Option D: It is especially sensitive to shock and heat. " B 4510 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(CO[N+](=O)[O-])O[N+](=O)[O-])O[N+](=O)[O-] Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It is a sensitive high explosive. Option B: It is sensitive to light. Option C: It becomes shock sensitive. Option D: It is especially sensitive to shock and heat. " C 48132 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1([C@H]([C@H]1C(=O)O[C@H](C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C(C(Br)(Br)Br)Br)C Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It is especially sensitive to shock and heat. Option B: It can harm sensitive individuals. Option C: It is a sensitive high explosive. Option D: It becomes shock sensitive. " B 6436606 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1([C@H]([C@H]1C(=O)O[C@H](C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)/C=C\\C(=O)OC(C(F)(F)F)C(F)(F)F)C Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It is a sensitive high explosive. Option B: It can harm sensitive individuals. Option C: It is especially sensitive to shock and heat. Option D: It becomes shock sensitive. " B 11022444 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(#[N+][O-])[Hg]C#[N+][O-] Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It is sensitive to friction in the dry state. Option B: It is especially sensitive to shock and heat. Option C: It is highly sensitive to friction and shock. Option D: It is sensitive to light. " C 443884 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H](CO)NC(=O)[C@H]1CN([C@@H]2CC3=CNC4=CC=CC(=C34)C2=C1)C Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It is especially sensitive to shock and heat. Option B: It is sensitive to friction in the dry state. Option C: It is highly sensitive to friction and shock. Option D: The uterus is sensitive to its oxytocic effect. " D 5281874 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=C(C(=C1F)F)COC(=O)C2C(C2(C)C)/C=C(/C(F)(F)F)\\Cl)F)F Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It is a sensitive high explosive. Option B: It becomes shock sensitive. Option C: It can harm sensitive individuals. Option D: It is especially sensitive to shock and heat. " C 38283 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CC1C(C1(C)C)C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It is especially sensitive to shock and heat. Option B: It is a sensitive high explosive. Option C: It becomes shock sensitive. Option D: It can harm sensitive individuals. " D 16850 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=O)OC23C4=C(C=C(C=C4)O)OC5=C3C=CC(=C5)O Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It is sensitive to light. Option B: It may be sensitive to prolonged exposure to light. Option C: It is sensitive to air and light. Option D: It is especially sensitive to shock and heat. " B 2723790 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=S)(N)N Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It is insensitive to this molecule treatment. Option B: It can acquire a greenish-brown tint under exposure to sunlight. Option C: Sensitivity to this molecule can be identified with a clinical patch test. Option D: The C=S bond is insensitive to the nature of the substitutent. " D 6518 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(CO[N+](=O)[O-])(CO[N+](=O)[O-])CO[N+](=O)[O-])O[N+](=O)[O-] Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It is sensitive to light. Option B: It is especially sensitive to shock and heat. Option C: It is sensitive to air and light. Option D: It may be sensitive to prolonged exposure to light. " B 11715 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)CBr Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It can harm sensitive individuals. Option B: Skin contact can produce irritation, itching, swelling, and general discomfort. Option C: It has no sensitivity. Option D: It increases insulin sensitivity. " B 47326 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C(C1(C)C)C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It can harm sensitive individuals. Option B: It becomes shock sensitive. Option C: It is especially sensitive to shock and heat. Option D: It is a sensitive high explosive. " A 5315892 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)/C=C/CO Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: Sensitivity to this molecule can be identified with a clinical patch test. Option B: It exhibits bluish-violet fluorescence in UV light. Option C: Skin contact can produce irritation, itching, swelling, and general discomfort. Option D: It can increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. " A 61948 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(CBr)(C#N)Br)C#N Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: Sensitivity to this molecule can be identified with a clinical patch test. Option B: The C=S bond is insensitive to the nature of the substitutent. Option C: It can be identified with a clinical patch test. Option D: It is insensitive to this molecule treatment. " C 3310889 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1NN)[N+](=O)[O-] Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It is especially sensitive to shock and heat. Option B: It is sensitive to light. Option C: It is highly sensitive to friction and shock. Option D: It is sensitive to friction in the dry state. " D 7862 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[Hg]Cl Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It is sensitive to air and light. Option B: It may be sensitive to prolonged exposure to light. Option C: It is especially sensitive to shock and heat. Option D: It is sensitive to light. " D 7242 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1N Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It may be sensitive to prolonged exposure to light. Option B: It is sensitive to light. Option C: It is especially sensitive to shock and heat. Option D: It is sensitive to air and light. " D 6001 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C2C=CC3=CC=CC=C3C2=C(C4=CC=CC=C14)C Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: Skin contact can produce irritation, itching, swelling, and general discomfort. Option B: Sensitivity to this molecule can be identified with a clinical patch test. Option C: It can acquire a greenish-brown tint under exposure to sunlight. Option D: It exhibits bluish-violet fluorescence in UV light. " D 23976 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Cr] Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It has no sensitivity. Option B: It increases insulin sensitivity. Option C: It can harm sensitive individuals. Option D: It becomes shock sensitive. " B 7888 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CCCC(C)(C)O)CC=O Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: Sensitivity to this molecule can be identified with a clinical patch test. Option B: It is insensitive to this molecule treatment. Option C: It can be identified with a clinical patch test. Option D: The C=S bond is insensitive to the nature of the substitutent. " C 7543 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1CC2=CC(=C(C=C2)N)Cl)Cl)N Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It increases insulin sensitivity. Option B: It can harm sensitive individuals. Option C: It has no sensitivity. Option D: It becomes shock sensitive. " C 2912 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C(C1C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C=C(Cl)Cl)C Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It becomes shock sensitive. Option B: It can harm sensitive individuals. Option C: It is a sensitive high explosive. Option D: It is especially sensitive to shock and heat. " B 8295 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCl)OP(=O)(OCCCl)OCCCl Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It becomes shock sensitive. Option B: It has no sensitivity. Option C: It can harm sensitive individuals. Option D: It increases insulin sensitivity. " B 12797557 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[C@@H](C1=CC=C(C=C1)OC(F)F)C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3 Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It is a sensitive high explosive. Option B: It is especially sensitive to shock and heat. Option C: It can harm sensitive individuals. Option D: It becomes shock sensitive. " C 146570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCC[C@@]1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: Sensitivity to this molecule can be identified with a clinical patch test. Option B: It can increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option C: It exhibits bluish-violet fluorescence in UV light. Option D: Skin contact can produce irritation, itching, swelling, and general discomfort. " B 33344 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C(=O)C=C(S1)Cl Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: The C=S bond is insensitive to the nature of the substitutent. Option B: It is insensitive to this molecule treatment. Option C: Sensitivity to this molecule can be identified with a clinical patch test. Option D: It can be identified with a clinical patch test. " D 7108 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)NC3=CC=CC=C3S2 Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: Skin contact can produce irritation, itching, swelling, and general discomfort. Option B: Sensitivity to this molecule can be identified with a clinical patch test. Option C: It exhibits bluish-violet fluorescence in UV light. Option D: It can acquire a greenish-brown tint under exposure to sunlight. " D 3291 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC1(CC(=O)NC1=O)C Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It can harm sensitive individuals. Option B: It increases insulin sensitivity. Option C: It has no sensitivity. Option D: It can be strongly blocked by mibefradil. " D 9033 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN1 Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It can harm sensitive individuals. Option B: It can cause third degree chemical burns of the skin. Option C: It becomes shock sensitive. Option D: It is a sensitive high explosive. " B 6305 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)O)N Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: It is a sensitive high explosive. Option B: It can be found in low fat cottage cheese and chicken and turkey. Option C: It becomes shock sensitive. Option D: It can harm sensitive individuals. " B 7573 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NC1=CC=C(C=C1)NC2=CC=CC=C2 Question about this molecule: Which kind of sensitivity does this molecule have/exhibit? Option A: The C=S bond is insensitive to the nature of the substitutent. Option B: It can be identified with a clinical patch test. Option C: It is insensitive to this molecule treatment. Option D: Sensitivity to this molecule can be identified with a clinical patch test. " B 379 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCC(=O)O Question about this molecule: What is the smell of this molecule? Option A: It has a sweet smell. Option B: It has a slightly unpleasant rancid-like smell. Option C: It has an unpleasant sulfur-like smell. Option D: It has a faint almond-like smell. " B 273 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCN)CCN Question about this molecule: What is the smell of this molecule? Option A: It has a sharp, unpleasant smell. Option B: It is foul-smelling. Option C: It has a distinctive smell. Option D: It has a sweet smell. " B 5975 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C-]#N Question about this molecule: What is the smell of this molecule? Option A: It has a distinctive smell. Option B: It has a characteristically sharp smell. Option C: It has a sweet smell. Option D: It has a faint almond-like smell. " D 6575 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=C(Cl)Cl)Cl Question about this molecule: What is the smell of this molecule? Option A: It has a sharp, unpleasant smell. Option B: It has a distinctive smell. Option C: It has a characteristically sharp smell. Option D: It has a sweet smell. " D 7501 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC1=CC=CC=C1 Question about this molecule: What is the smell of this molecule? Option A: It has a sharp, unpleasant smell. Option B: It has a sweet smell. Option C: It has a characteristically sharp smell. Option D: It has a distinctive smell. " A 8252 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC=C Question about this molecule: What is the smell of this molecule? Option A: It has a characteristically sharp smell. Option B: It is stenched. Option C: It has a distinctive smell. Option D: It has a sweet smell. " B 31211 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)CCC1=CC(=C(C=C1)O)OC Question about this molecule: What is the smell of this molecule? Option A: It is pungent. Option B: It has a distinct, pungent smell. Option C: It has a pungent smell. Option D: It has a distinctive smell. " A 1493 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])O Question about this molecule: What is the smell of this molecule? Option A: It has neither odor nor taste. Option B: It has no smell or taste. Option C: It has no smell. Option D: It has a sweet smell. " C 6544 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=O)CC(C1)(C)C Question about this molecule: What is the smell of this molecule? Option A: It has a sweet smell. Option B: It smells like peppermint. Option C: It has a faint almond-like smell. Option D: It smells like turpentine. " B 7847 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC=O Question about this molecule: What is the smell of this molecule? Option A: It has the smell of lilac, lily, and lily of the valley. Option B: It has a sweet smell that can be detected at low levels. Option C: It has a mild, irritating smell. Option D: It has a piercing, disagreeable, acrid smell. " D 712 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=O Question about this molecule: What is the smell of this molecule? Option A: It has a distinct, pungent smell. Option B: It has a sweet smell. Option C: It has a pungent smell. Option D: It has a distinctive smell. " A 1140 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1 Question about this molecule: What is the smell of this molecule? Option A: It has a distinctive smell. Option B: It has a characteristically sharp smell. Option C: It has a sharp, unpleasant smell. Option D: It has a sweet smell. " A 6214 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)(Cl)Cl)(Cl)(Cl)Cl Question about this molecule: What is the smell of this molecule? Option A: It has a distinctive smell. Option B: The smell is like camphor. Option C: The smell is not known. Option D: It has no smell. " B 6337 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCl Question about this molecule: What is the smell of this molecule? Option A: It has a sharp, unpleasant smell. Option B: It has a distinctive smell. Option C: It has a sweet smell. Option D: It has a characteristically sharp smell. " D 3286 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)SCSP(=S)(OCC)OCC Question about this molecule: What is the smell of this molecule? Option A: It has a faint almond-like smell. Option B: It has a sweet smell. Option C: It has an unpleasant sulfur-like smell. Option D: It has a distinctive smell. " C 7888 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CCCC(C)(C)O)CC=O Question about this molecule: What is the smell of this molecule? Option A: It has a mild, irritating smell. Option B: It has a sweet smell that can be detected at low levels. Option C: It has a piercing, disagreeable, acrid smell. Option D: It has the smell of lilac, lily, and lily of the valley. " D 7543 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1CC2=CC(=C(C=C2)N)Cl)Cl)N Question about this molecule: What is the smell of this molecule? Option A: It has no smell or taste. Option B: It has no smell. Option C: It has a sweet smell. Option D: It has neither odor nor taste. " A 5943 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)(Cl)(Cl)Cl Question about this molecule: What is the smell of this molecule? Option A: It has a sweet smell. Option B: It has a mild, irritating smell. Option C: It has a sweet smell that can be detected at low levels. Option D: It has a sharp, unpleasant smell. " C 10461 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCl)SCCCl Question about this molecule: What is the smell of this molecule? Option A: It has a distinctive smell. Option B: It has a garlic-like smell. Option C: It has a sweet smell. Option D: It has a faint almond-like smell. " B 222 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: N Question about this molecule: What is the smell of this molecule? Option A: It has a pungent smell. Option B: It has a sweet smell. Option C: It has a distinct, pungent smell. Option D: It has a distinctive smell. " A 8029 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=COC=C1 Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is readily soluble in water. Option C: It is insoluble in water. Option D: It is practically insoluble in water. " C 7762 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(=O)OCC Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is insoluble in water. Option C: It is readily soluble in water. Option D: It is soluble in water. " B 5281873 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C(C1C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)/C=C(/C(F)(F)F)\\Cl)C Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water. Option B: It is soluble in water. Option C: It is practically insoluble in water. Option D: It is readily soluble in water. " A 280 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)=O Question about this molecule: How is the solubility of this molecule Option A: It is soluble in boiling water. Option B: It is practically insoluble in water. Option C: It is soluble in water. Option D: It is readily soluble in water. " C 1054 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NC=C(C(=C1O)CO)CO Question about this molecule: How is the solubility of this molecule Option A: They are water-soluble. Option B: It is insoluble in water. Option C: It is water-soluble. Option D: It is water insoluble. " C 9731 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1N)F Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is insoluble in water. Option C: It is soluble in water. Option D: It is practically insoluble in water. " B 2268 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=S)(OC)SCN1C(=O)C2=CC=CC=C2N=N1 Question about this molecule: How is the solubility of this molecule Option A: It is poorly soluble in water. Option B: It is readily soluble in water. Option C: It is quite soluble in water. Option D: It is highly soluble in water. " A 31246 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(=O)CCC Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is practically insoluble in water. Option C: It is insoluble in water. Option D: It is soluble in water. " C 10907 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CC(C)(C)C Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is soluble in water. Option C: It is insoluble in water. Option D: It is practically insoluble in water. " C 516902 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]Cl(=O)=O.[Na+] Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is soluble in boiling water. Option C: Appreciably soluble in water Option D: Easily soluble in water " C 24085 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: Cl[Hg]Cl Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is highly soluble in water. Option C: It is poorly soluble in water. Option D: It is quite soluble in water. " B 2719 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is readily soluble in water. Option C: It is soluble in boiling water. Option D: It is practically insoluble in water. " A 10967 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(OCCl)Cl Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: Easily soluble in water Option C: It is soluble in boiling water. Option D: It is soluble in water. " B 4004 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)CC(C(=O)OCC)SP(=S)(OC)OC Question about this molecule: How is the solubility of this molecule Option A: Soluble in many substances Option B: Soluble in alcohol Option C: Soluble in aqueous base Option D: Soluble in a solvent " D 6569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)C Question about this molecule: How is the solubility of this molecule Option A: Soluble in a solvent Option B: Soluble in aqueous base Option C: Soluble in alcohol Option D: Soluble in many substances " D 1486 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1Cl)Cl)OCC(=O)O Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is readily soluble in water. Option C: It is practically insoluble in water. Option D: It is insoluble in water. " D 6278 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(Cl)(Cl)Cl Question about this molecule: How is the solubility of this molecule Option A: It does not mix well with water Option B: It does not dissolve easily in water. Option C: Solvent for organic compounds Option D: It does not dissolve in water very easily. " C 297 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is practically insoluble in water. Option C: It is insoluble in water. Option D: It is readily soluble in water. " C 2256 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC1=NC(=NC(=N1)Cl)NC(C)C Question about this molecule: How is the solubility of this molecule Option A: It will dissolve in water. Option B: It dissolves easily in water. Option C: It sinks in water. Option D: They readily dissolve in water. " A 6589 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C(C)C Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is soluble in water. Option C: It is insoluble in water. Option D: It is practically insoluble in water. " C 7840 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCBr Question about this molecule: How is the solubility of this molecule Option A: It is very slightly soluble in water. Option B: It is slightly soluble in water. Option C: It is highly soluble in water. Option D: It is insoluble to slightly soluble in water. " B 11443 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)N=C=O)N=C=O Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water. Option B: It is practically insoluble in water. Option C: It is readily soluble in water. Option D: It is soluble in water. " A 957 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCO Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water. Option B: It is soluble in water. Option C: It is practically insoluble in water. Option D: It is readily soluble in water. " A 6954 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1[N+](=O)[O-])O)[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: How is the solubility of this molecule Option A: It is moderately soluble in water. Option B: It is minimally soluble in water. Option C: It is highly soluble in water. Option D: It is poorly soluble in water. " A 8103 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCO Question about this molecule: How is the solubility of this molecule Option A: It is slightly soluble in water. Option B: It is insoluble to slightly soluble in water. Option C: It is highly soluble in water. Option D: It is very slightly soluble in water. " A 6945 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)[N+](=O)[O-])Cl Question about this molecule: How is the solubility of this molecule Option A: It will dissolve in water. Option B: It sinks in water. Option C: It dissolves easily in water. Option D: They readily dissolve in water. " B 6184 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC=O Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is soluble in water. Option C: It is insoluble in water. Option D: It is practically insoluble in water. " C 6359 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)(Cl)Br Question about this molecule: How is the solubility of this molecule Option A: They readily dissolve in water. Option B: It dissolves easily in water. Option C: Some of it will dissolve in water. Option D: It will dissolve in water. " C 31260 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CCO Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is readily soluble in water. Option C: It is practically insoluble in water. Option D: It is soluble in boiling water. " A 25514 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [NH4+].[Br-] Question about this molecule: How is the solubility of this molecule Option A: It mixes with water. Option B: It mixes in water. Option C: It sinks in and mixes with water. Option D: It sinks and mixes with water. " B 379 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCC(=O)O Question about this molecule: How is the solubility of this molecule Option A: It is minimally soluble in water. Option B: It is poorly soluble in water. Option C: It is highly soluble in water. Option D: It is moderately soluble in water. " A 64929 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C(=O)O)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl Question about this molecule: How is the solubility of this molecule Option A: It has low aqueous solubility. Option B: It has improved solubility. Option C: It has a low solubility profile. Option D: It has low solubility. " B 6419 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)(Cl)Cl)(Cl)Cl Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water. Option B: It is soluble in water. Option C: It is readily soluble in water. Option D: It is practically insoluble in water. " A 638014 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(CCC1)(C)C)/C=C/C(=O)C Question about this molecule: How is the solubility of this molecule Option A: It is moderately soluble in most organic solvents. Option B: It is moderately soluble in organic solvents. Option C: It is soluble in very dilute alcoholic solution. Option D: It is soluble in organic solvents. " C 6405 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C)(C)O Question about this molecule: How is the solubility of this molecule Option A: It is highly soluble in water. Option B: It is very slightly soluble in water. Option C: It is slightly soluble in water. Option D: It is insoluble to slightly soluble in water. " C 24424 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]S(=O)(=O)[O-].[Zn+2] Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is soluble in boiling water. Option C: It is soluble in water. Option D: All forms are soluble in water. " D 7329 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1Cl)SC2=C(C=CC(=C2)Cl)O)O Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water. Option B: It is readily soluble in water. Option C: It is soluble in water. Option D: It is practically insoluble in water. " A 7344 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C(C)O Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is readily soluble in water. Option C: It is practically insoluble in water. Option D: It is soluble in boiling water. " A 6049 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CN(CC(=O)O)CC(=O)O)N(CC(=O)O)CC(=O)O Question about this molecule: How is the solubility of this molecule Option A: It is very slightly soluble in water. Option B: It is insoluble to slightly soluble in water. Option C: It is slightly soluble in water. Option D: It is highly soluble in water. " C 6658 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=C)C(=O)OC Question about this molecule: How is the solubility of this molecule Option A: It is insoluble to slightly soluble in water. Option B: It is very slightly soluble in water. Option C: It is slightly soluble in water. Option D: It is highly soluble in water. " C 25457 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCC1=CC=CC=C1S(=O)(=O)O Question about this molecule: How is the solubility of this molecule Option A: It is soluble in boiling water. Option B: It is readily soluble in water. Option C: It is practically insoluble in water. Option D: It is soluble in water. " D 24934 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-][Se](=O)[O-].[Na+].[Na+] Question about this molecule: How is the solubility of this molecule Option A: It is soluble in boiling water. Option B: It is practically insoluble in water. Option C: It is readily soluble in water. Option D: It is soluble in water. " D 335 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1O Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is insoluble in water. Option C: It is soluble in water. Option D: It is readily soluble in water. " B 18171 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)[O-])C(CC(=O)[O-])(C(=O)O)O.[NH4+].[NH4+] Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is soluble in water. Option C: It is soluble in boiling water. Option D: It is practically insoluble in water. " B 8058 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is soluble in water. Option C: It is readily soluble in water. Option D: It is insoluble in water. " D 179 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C(=O)C)O Question about this molecule: How is the solubility of this molecule Option A: It will dissolve in water. Option B: It sinks in water. Option C: It dissolves easily in water. Option D: They readily dissolve in water. " B 7367 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(Cl)(Cl)Cl Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is insoluble in water. Option C: It is readily soluble in water. Option D: It is soluble in water. " B 5280567 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=O)OC2=C1C=CC(=C2)O Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is insoluble in water. Option C: It is soluble in water. Option D: It is readily soluble in water. " B 6421 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(Cl)(Cl)Cl)O Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is soluble in water. Option C: It is soluble in water with release of heat. Option D: It is soluble in water and sinks in water. " C 674 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC Question about this molecule: How is the solubility of this molecule Option A: It is very soluble in pure water, but will become soluble if the aqueous solution is acidic due to formation of ammonium salts, as usual for organic amines. Option B: It is slightly soluble in water and soluble in organic solvents. Option C: It dissolves readily in water to form flammable corrosive solutions. Option D: Insoluble in water, but often formulated as a wettable powder. " C 10208 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=CC=C3O Question about this molecule: How is the solubility of this molecule Option A: It is insoluble to slightly soluble in water. Option B: It is highly soluble in water. Option C: It is slightly soluble in water. Option D: It is very slightly soluble in water. " C 7541 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)NC2=NC(=NC(=N2)Cl)Cl)Cl Question about this molecule: How is the solubility of this molecule Option A: It is soluble in organic solvents. Option B: It is soluble in most organic liquids. Option C: It is moderately soluble in organic solvents. Option D: It is moderately soluble in most organic solvents. " C 6579 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC(=O)N Question about this molecule: How is the solubility of this molecule Option A: It is soluble in boiling water. Option B: It is soluble in water. Option C: It is practically insoluble in water. Option D: It is readily soluble in water. " B 5975 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C-]#N Question about this molecule: How is the solubility of this molecule Option A: It sinks in water. Option B: It will dissolve in water. Option C: They readily dissolve in water. Option D: It dissolves easily in water. " C 243 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(=O)O Question about this molecule: How is the solubility of this molecule Option A: It is highly soluble in water. Option B: It is slightly soluble in water. Option C: It is very slightly soluble in water. Option D: It is insoluble to slightly soluble in water. " B 115224 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CSC(=NC#N)N1CC2=CN=C(C=C2)Cl Question about this molecule: How is the solubility of this molecule Option A: They are water-soluble. Option B: It is insoluble in water. Option C: It is water insoluble. Option D: It is water-soluble. " A 6568 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C)O Question about this molecule: How is the solubility of this molecule Option A: It is soluble in boiling water. Option B: It is soluble in water. Option C: It is readily soluble in water. Option D: It is practically insoluble in water. " B 938 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CN=C1)C(=O)O Question about this molecule: How is the solubility of this molecule Option A: They are water-soluble. Option B: It is water-soluble. Option C: It is insoluble in water. Option D: It is water insoluble. " B 5280795 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](CCCC(C)C)[C@H]1CC[C@@H]\\2[C@@]1(CCC/C2=C\\C=C/3\\C[C@H](CCC3=C)O)C Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water. Option B: It is readily soluble in water. Option C: It is water insoluble. Option D: It is practically insoluble in water. " C 12592 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCCCCCCCCCCCCC Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is practically insoluble in water. Option C: It is insoluble in water. Option D: It is soluble in water. " C 6366 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=C(Cl)Cl Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is soluble in water. Option C: It is practically insoluble in water. Option D: It is insoluble in water. " D 261 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC=O Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is readily soluble in water. Option C: It is insoluble in water. Option D: It is soluble in water. " C 16402 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCCN)CCN Question about this molecule: How is the solubility of this molecule Option A: It is soluble in boiling water. Option B: It is readily soluble in water. Option C: It is soluble in water. Option D: It is practically insoluble in water. " C 2230 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CCC=C(C1)C(=O)OC Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water, alcohols, and ether. Option B: It dissolves readily in water to form flammable corrosive solutions. Option C: It is very soluble in pure water, but will become soluble if the aqueous solution is acidic due to formation of ammonium salts, as usual for organic amines. Option D: It is slightly soluble in water and soluble in organic solvents. " A 7720 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(CC)CO Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is readily soluble in water. Option C: It is soluble in water. Option D: It is insoluble in water. " D 6417 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)C(=O)O Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water, ethyl alcohol, and diethyl ether. Option B: It is soluble in water, alcohols, and ether. Option C: It is very soluble in pure water, but will become soluble if the aqueous solution is acidic due to formation of ammonium salts, as usual for organic amines. Option D: It is slightly soluble in water and soluble in organic solvents. " A 6947 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)[N+](=O)[O-])O Question about this molecule: How is the solubility of this molecule Option A: It sinks in and mixes slowly with water. Option B: It sinks and mixes slowly with water. Option C: It sinks in and mixes with water. Option D: It mixes slowly with water. " A 7438 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CCC(CC1O)C(=C)C Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is insoluble in water. Option C: It is soluble in water. Option D: It is readily soluble in water. " B 3739 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=C(C(=C1I)NC(=O)CCCCC(=O)NC2=C(C=C(C(=C2I)C(=O)O)I)I)I)C(=O)O)I Question about this molecule: How is the solubility of this molecule Option A: It is water-soluble. Option B: It is water insoluble. Option C: It is insoluble in water. Option D: They are water-soluble. " A 7852 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN Question about this molecule: How is the solubility of this molecule Option A: It is soluble in boiling water. Option B: It is soluble in water. Option C: It is readily soluble in water. Option D: It is practically insoluble in water. " B 18430 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C(O1)CBr Question about this molecule: How is the solubility of this molecule Option A: It is insoluble to slightly soluble in water. Option B: It is very slightly soluble in water. Option C: It is slightly soluble in water. Option D: It is highly soluble in water. " C 8905 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CNCCN1.C(CCC(=O)O)CC(=O)O Question about this molecule: How is the solubility of this molecule Option A: It sinks and mixes slowly with water. Option B: It sinks in and mixes slowly with water. Option C: It dissolves slowly. Option D: It mixes slowly with water. " C 4875 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [K+].[I-] Question about this molecule: How is the solubility of this molecule Option A: It mixes with water. Option B: It readily mixes with water. Option C: It sinks and mixes with water. Option D: It sinks in and mixes with water. " C 3017 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OC1=NC(=NC(=C1)C)C(C)C Question about this molecule: How is the solubility of this molecule Option A: It does not mix well with water Option B: It does not dissolve in water very easily. Option C: It doesn't dissolve easily in water. Option D: It does not dissolve easily in water. " D 7342 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C(C)C Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is insoluble in water. Option C: It is soluble in water. Option D: It is readily soluble in water. " B 15413 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)OC Question about this molecule: How is the solubility of this molecule Option A: It is miscible in most organic solvents. Option B: It completely mixes with water. Option C: It is miscible with water. Option D: It is miscible in water. " D 6212 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)(Cl)Cl Question about this molecule: How is the solubility of this molecule Option A: It is slightly soluble in water. Option B: It is highly soluble in water. Option C: It is very slightly soluble in water. Option D: It is insoluble to slightly soluble in water. " A 7501 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC1=CC=CC=C1 Question about this molecule: How is the solubility of this molecule Option A: It doesn't dissolve easily in water. Option B: It does not dissolve easily in water. Option C: It does not mix well with water Option D: It does not dissolve in water very easily. " A 6782 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)COC(=O)C1=CC=CC=C1C(=O)OCC(C)C Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is practically insoluble in water. Option C: It is readily soluble in water. Option D: It is insoluble in water. " D 6125 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(=O)[O-])[O-].[Na+].[Na+] Question about this molecule: How is the solubility of this molecule Option A: It sinks in and mixes slowly with water. Option B: It sinks in and mixes with water. Option C: It mixes slowly with water. Option D: It sinks and mixes slowly with water. " D 6228 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C=O Question about this molecule: How is the solubility of this molecule Option A: It is very slightly soluble in water and soluble in organic solvents. Option B: It has extensive miscibility with water and most common organic solvents. Option C: It is only slightly soluble in cold water but dissolves readily in hot water and most organic solvents. Option D: It is very soluble in most polar organic solvents, as well as in water. " B 2969 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCC(=O)O Question about this molecule: How is the solubility of this molecule Option A: It is very slightly soluble in water and soluble in organic solvents. Option B: It is soluble in most organic solvents and in dilute nitric acid. Option C: It is very soluble in most polar organic solvents, as well as in water. Option D: It is only slightly soluble in cold water but dissolves readily in hot water and most organic solvents. " B 6857599 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC[C@H]([C@@H](C1)N)N.C(=O)(C(=O)O)O.[Pt+2] Question about this molecule: How is the solubility of this molecule Option A: It has improved water solubility due to the replacement of chlorine ligands by oxalato bidentate. Option B: It is a highly water-soluble salt often used as a fertilizer and food additive as a source of phosphorus and potassium as well as a buffering agent. Option C: It dissolves readily in water to form flammable corrosive solutions. Option D: It is very soluble in pure water, but will become soluble if the aqueous solution is acidic due to formation of ammonium salts, as usual for organic amines. " A 2202 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C2=C(C(=CC=C2)O)C(=O)C3=C1C=CC=C3O Question about this molecule: How is the solubility of this molecule Option A: It is well absorbed through the epidermis due to its dual solubility. Option B: It has improved water solubility due to the replacement of chlorine ligands by oxalato bidentate. Option C: It dissolves in water to form flammable, corrosive solutions. Option D: A 1% solution in water is slightly alkaline to litmus. " A 8489 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC(=C1)Cl)[N+](=O)[O-] Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water. Option B: It is soluble in water. Option C: It is practically insoluble in water. Option D: It is readily soluble in water. " A 8180 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCC(=O)O Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is readily soluble in water. Option C: It is soluble in water. Option D: It is insoluble in water. " D 6224 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Na+].[Na+].[Na+] Question about this molecule: How is the solubility of this molecule Option A: It is freely soluble in water and practically insoluble in alcohol. Option B: It is insoluble in water and partially soluble in alcohol. Option C: It is insoluble in water and soluble in alcohols and oils. Option D: It is soluble in water and insoluble in alcohol. " A 7514 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC1CCCCC1 Question about this molecule: How is the solubility of this molecule Option A: It is slightly soluble in water and floats on water. Option B: It is less dense than water and soluble in water. Option C: It is soluble in water and less dense than water. Option D: It is slightly soluble in water and denser than water. " A 6629 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C1=CC=CC=C1)OO Question about this molecule: How is the solubility of this molecule Option A: It is slightly soluble in water and denser than water. Option B: It is insoluble in water and slightly denser than water. Option C: It is insoluble in water and denser than water. Option D: It is generally denser than water and insoluble in water. " A 8076 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOCCO Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water, alcohols, and ether. Option B: It is soluble in water, ethyl alcohol, and diethyl ether. Option C: It is miscible with water, ethanol, diethyl ether, acetone, and ethyl acetate. Option D: It is slightly soluble in water and soluble in organic solvents. " C 25000 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N+](=O)([O-])[O-].[N+](=O)([O-])[O-].[Co+2] Question about this molecule: How is the solubility of this molecule Option A: It sinks and mixes with water. Option B: It readily mixes with water. Option C: It sinks in and mixes with water. Option D: It mixes with water. " A 853433 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C=C/C1=CC(=C(C=C1)O)OC Question about this molecule: How is the solubility of this molecule Option A: It is slightly soluble in water and floats on water. Option B: It is very slightly soluble in water and soluble in organic solvents. Option C: It is only slightly soluble in cold water but dissolves readily in hot water and most organic solvents. Option D: It is very soluble in most polar organic solvents, as well as in water. " B 5976 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)N Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water and less dense than water. Option B: It is less dense than water and insoluble in water. Option C: It is less dense than water and soluble in water. Option D: It is soluble in water and less dense than water. " D 8038 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)COC(=O)C Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water and less dense than water. Option B: It is less dense than water and insoluble in water. Option C: It is less dense than water and soluble in water. Option D: It is soluble in water and less dense than water. " A 24726 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(/C=C/Cl)Cl Question about this molecule: How is the solubility of this molecule Option A: It will dissolve in water. Option B: It sinks in water. Option C: It dissolves easily in water. Option D: They readily dissolve in water. " B 4192 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NC=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4F Question about this molecule: How is the solubility of this molecule Option A: It is water-soluble at pH less than 4 and lipid-soluble at physiological pH. Option B: It is very soluble in most polar organic solvents, as well as in water. Option C: It is very slightly soluble in water and soluble in organic solvents. Option D: It is a water-soluble, white crystalline solid compound consisting of hydrogen peroxide and urea. " A 3039 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=O)(OC)OC=C(Cl)Cl Question about this molecule: How is the solubility of this molecule Option A: It sinks and mixes with water. Option B: It readily mixes with water. Option C: It mixes with water. Option D: It sinks in and mixes with water. " B 24460 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-][Cr](=O)(=O)[O-].[Pb+2] Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water. Option B: It is readily soluble in water. Option C: It is one of the most insoluble salts. Option D: It is practically insoluble in water. " C 11883 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=C(C=C1)[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: How is the solubility of this molecule Option A: Solid and liquid sink in water. Option B: It is soluble in water and sinks in water. Option C: It is soluble in water and less dense than water. Option D: It is insoluble in water and less dense than water. " A 787 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: NO Question about this molecule: How is the solubility of this molecule Option A: It mixes with water. Option B: It sinks in and mixes with water. Option C: It sinks and mixes with water. Option D: It readily mixes with water. " C 1480 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=CC(=C1Cl)Cl)Cl)OCC(=O)O Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is insoluble in water. Option C: It is practically insoluble in water. Option D: It is soluble in water. " B 2314 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(OC2=C(O1)C(=CC=C2)OC(=O)NC)C Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is practically insoluble in water. Option C: It is readily soluble in water. Option D: It is insoluble in water. " D 3598 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water and denser than water. Option B: It is generally denser than water and insoluble in water. Option C: It is slightly soluble in water and denser than water. Option D: It is insoluble in water and slightly denser than water. " A 31294 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(N)N.OO Question about this molecule: How is the solubility of this molecule Option A: It is a white solid dissolved in a liquid carrier. Option B: It is soluble in water, alcohols, and ether. Option C: It is a water-soluble, white crystalline solid compound consisting of hydrogen peroxide and urea. Option D: It is slightly soluble in water and soluble in organic solvents. " C 8418 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C=C3C=CC=CC3=CC2=C1 Question about this molecule: How is the solubility of this molecule Option A: They readily dissolve in water. Option B: It sinks in water. Option C: It will dissolve in water. Option D: It dissolves easily in water. " B 31373 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=C(Cl)Cl)(Cl)Cl Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water. Option B: It is practically insoluble in water. Option C: It is soluble in water. Option D: It is readily soluble in water. " A 4632 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC(=C(C=C1)C(=O)C2=CC=CC=C2)O Question about this molecule: How is the solubility of this molecule Option A: It is moderately soluble in organic solvents. Option B: It is soluble in organic solvents. Option C: It forms colorless crystals that are readily soluble in most organic solvents. Option D: It is moderately soluble in most organic solvents. " C 29393 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN(CCC)C1=C(C=C(C=C1[N+](=O)[O-])S(=O)(=O)N)[N+](=O)[O-] Question about this molecule: How is the solubility of this molecule Option A: It has low aqueous solubility. Option B: It has a high level of solubility. Option C: It has a low solubility profile. Option D: It has a low aqueous solubility. " D 757 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)O)O Question about this molecule: How is the solubility of this molecule Option A: It is quite soluble in water. Option B: It is poorly soluble in water. Option C: It is highly soluble in water. Option D: It is readily soluble in water. " C 11 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCl)Cl Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water. Option B: It is practically insoluble in water. Option C: It is soluble in water. Option D: It is readily soluble in water. " A 949 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C1=CC=CC=C1 Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is insoluble in water. Option C: It is practically insoluble in water. Option D: It is readily soluble in water. " B 71771 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)CC(=O)OCC(=O)O)NC2=C(C=CC=C2Cl)Cl Question about this molecule: How is the solubility of this molecule Option A: It possesses poor aqueous solubility. Option B: It has low aqueous solubility. Option C: It has a low solubility profile. Option D: It has a low aqueous solubility. " A 1119 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=S=O Question about this molecule: How is the solubility of this molecule Option A: It does not dissolve easily in water. Option B: It dissolves only slightly in water. Option C: It dissolves in water very easily. Option D: It does not dissolve in water very easily. " C 6097028 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [NH4+].[NH4+].[O-]S(=O)(=O)[O-] Question about this molecule: How is the solubility of this molecule Option A: It will dissolve in water. Option B: It dissolves easily in water. Option C: It sinks and dissolves in water. Option D: They readily dissolve in water. " C 1068 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CSC Question about this molecule: How is the solubility of this molecule Option A: It is insoluble to slightly soluble in water. Option B: It is highly soluble in water. Option C: It is slightly soluble in water. Option D: It is very slightly soluble in water. " C 7409 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C1=CC=CC=C1)O Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water. Option B: It is readily soluble in water. Option C: It is practically insoluble in water. Option D: It is soluble in water. " A 442070 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1[C@H]([C@@]2([C@@H](C2(C)C)[C@H]3[C@]1([C@@H]4C=C(C(=O)[C@]4(CC(=C3)CO)O)C)O)O)O Question about this molecule: How is the solubility of this molecule Option A: It is slightly soluble in water and floats on water. Option B: It is very soluble in most polar organic solvents, as well as in water. Option C: It is only slightly soluble in cold water but dissolves readily in hot water and most organic solvents. Option D: It is very slightly soluble in water and soluble in organic solvents. " B 6096946 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [NH4+].[NH4+].[O-]S(=O)(=S)[O-] Question about this molecule: How is the solubility of this molecule Option A: It is highly soluble in water. Option B: It is poorly soluble in water. Option C: It is quite soluble in water. Option D: It is very soluble in water " D 1088 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNCC(=O)O Question about this molecule: How is the solubility of this molecule Option A: It dissolves easily in water. Option B: It will dissolve in water. Option C: They readily dissolve in water. Option D: It dissolves in water " D 7430 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1Cl)N)Cl)[N+](=O)[O-] Question about this molecule: How is the solubility of this molecule Option A: Insoluble in water, but often formulated as a wettable powder. Option B: It dissolves readily in water to form flammable corrosive solutions. Option C: It is very soluble in pure water, but will become soluble if the aqueous solution is acidic due to formation of ammonium salts, as usual for organic amines. Option D: It is slightly soluble in water and soluble in organic solvents. " A 91756 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC1=NC(=NC(=N1)NC(=O)NS(=O)(=O)C2=CC=CC=C2C(=O)OC)NC Question about this molecule: How is the solubility of this molecule Option A: It is highly soluble in water. Option B: It is moderately soluble in water. Option C: It is poorly soluble in water. Option D: It is minimally soluble in water. " B 8370 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=C(C(=C(C(=C1Cl)Cl)Cl)Cl)Cl)Cl Question about this molecule: How is the solubility of this molecule Option A: Not soluble in water. Option B: It is highly soluble in water. Option C: It is poorly soluble in water. Option D: Not very soluble in water " D 30318 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=[Os](=O)(=O)=O Question about this molecule: How is the solubility of this molecule Option A: Soluble in many substances Option B: Soluble in alcohol Option C: Soluble in aqueous base Option D: Soluble in a solvent " B 1732 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CC(=C1)O)Cl Question about this molecule: How is the solubility of this molecule Option A: Soluble in a solvent Option B: Soluble in alcohol Option C: Soluble in many substances Option D: Soluble in aqueous base " D 196 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCC(=O)O)CC(=O)O Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water. Option B: It is readily soluble in water. Option C: It is soluble in water. Option D: It is practically insoluble in water. " A 24597 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-][Cr](=O)(=O)[O-].[K+].[K+] Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is practically insoluble in water. Option C: It is soluble in boiling water. Option D: It is readily soluble in water. " A 2730 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OC1=NC(=C(C=C1Cl)Cl)Cl Question about this molecule: How is the solubility of this molecule Option A: It doesn't dissolve easily in water. Option B: It does not dissolve easily in water. Option C: It does not mix well with water Option D: It does not dissolve in water very easily. " C 2519 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C=NC2=C1C(=O)N(C(=O)N2C)C Question about this molecule: How is the solubility of this molecule Option A: Solutions in water are neutral to litmus Option B: A 1% solution in water is slightly alkaline to litmus. Option C: It dissolves only slightly in water. Option D: It dissolves slightly in water. " A 12021 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)OC Question about this molecule: How is the solubility of this molecule Option A: It is highly soluble in water. Option B: It is insoluble to slightly soluble in water. Option C: It is very slightly soluble in water. Option D: It is slightly soluble in water. " D 5284484 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CNC(=S)[S-])NC(=S)[S-].[Zn+2] Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is practically insoluble in water. Option C: It is readily soluble in water. Option D: It is insoluble in water. " D 8094 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCC(=O)O Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is poorly soluble in water. Option C: It is highly soluble in water. Option D: It is quite soluble in water. " B 2879 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)O Question about this molecule: How is the solubility of this molecule Option A: It sinks in and mixes slowly with water. Option B: It mixes slowly with water. Option C: It sinks in and mixes with water. Option D: It sinks and mixes slowly with water. " D 1493 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])O Question about this molecule: How is the solubility of this molecule Option A: It is very slightly soluble in water. Option B: It is slightly soluble in water. Option C: It is insoluble to slightly soluble in water. Option D: It is highly soluble in water. " B 7700 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCC1=CC=C(C=C1)OCCO Question about this molecule: How is the solubility of this molecule Option A: It mixes with water. Option B: It mixes slowly with water. Option C: It sinks in and mixes with water. Option D: It sinks and mixes with water. " B 7551 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC(=C1)Cl)NC(=O)OCC#CCCl Question about this molecule: How is the solubility of this molecule Option A: It dissolves in water to form flammable, corrosive solutions. Option B: It has improved water solubility due to the replacement of chlorine ligands by oxalato bidentate. Option C: A 1% solution in water is slightly alkaline to litmus. Option D: Water solubility is 11 ppm at 20 °C. " D 5192 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCCCC(=O)O)CCCC(=O)O Question about this molecule: How is the solubility of this molecule Option A: It is insoluble to slightly soluble in water. Option B: It is slightly soluble in water. Option C: It is highly soluble in water. Option D: It is very slightly soluble in water. " B 6943 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C1=CC=CC=C1O Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is insoluble in water. Option C: It is readily soluble in water. Option D: It is practically insoluble in water. " B 7463 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)C(C)C Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water. Option B: It is soluble in water. Option C: It is readily soluble in water. Option D: It is practically insoluble in water. " A 24433 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOC(=O)C1=CC=CC=C1N Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is readily soluble in water. Option C: It is practically insoluble in water. Option D: It is insoluble in water. " D 10430 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CC(=O)O Question about this molecule: How is the solubility of this molecule Option A: It is very slightly soluble in water. Option B: It is highly soluble in water. Option C: It is insoluble to slightly soluble in water. Option D: It is slightly soluble in water. " D 7434 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C=C1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is soluble in water. Option C: It is insoluble in water. Option D: It is readily soluble in water. " C 31236 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)OCCO Question about this molecule: How is the solubility of this molecule Option A: It displays low water solubility. Option B: It has low solubility. Option C: It has low water solubility. Option D: It has low aqueous solubility. " C 24414 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]S(=O)(=O)[O-].[Ba+2] Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is soluble in water. Option C: It is insoluble in water. Option D: It is readily soluble in water. " C 14775 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Be]=O Question about this molecule: How is the solubility of this molecule Option A: It will dissolve in water. Option B: It dissolves easily in water. Option C: It sinks in water. Option D: They readily dissolve in water. " C 6720 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=C(C(=C(C(=C1Cl)Cl)Cl)Cl)Cl)[N+](=O)[O-] Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is practically insoluble in water. Option C: It is insoluble in water. Option D: It is soluble in water. " C 948 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N-]=[N+]=O Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is practically insoluble in water. Option C: It is soluble in water. Option D: It is soluble in boiling water. " C 590836 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCC(C)C Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water. Option B: It is readily soluble in water. Option C: It is practically insoluble in water. Option D: It is soluble in water. " A 4 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CN)O Question about this molecule: How is the solubility of this molecule Option A: It is soluble in boiling water. Option B: It is practically insoluble in water. Option C: It is soluble in water. Option D: It is readily soluble in water. " C 7239 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)Cl)Cl Question about this molecule: How is the solubility of this molecule Option A: It completely mixes with water. Option B: It is miscible in most organic solvents. Option C: It is miscible in water. Option D: It is miscible with water. " B 13190 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCC=C Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is insoluble in water. Option C: It is practically insoluble in water. Option D: It is readily soluble in water. " B 6574 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)Cl)Cl Question about this molecule: How is the solubility of this molecule Option A: They readily dissolve in water. Option B: It will dissolve in water. Option C: It is dissolved in water. Option D: It can be dissolved in water. " D 4771 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(CC1=CC=CC=C1)N Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is readily soluble in water. Option C: It is soluble in water. Option D: It is insoluble in water. " D 887 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CO Question about this molecule: How is the solubility of this molecule Option A: It mixes with water. Option B: It sinks and mixes with water. Option C: It completely mixes with water. Option D: It mixes slowly with water. " C 241 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=CC=C1 Question about this molecule: How is the solubility of this molecule Option A: It dissolves only slightly in water. Option B: It dissolves easily in water. Option C: It dissolves slightly in water. Option D: They readily dissolve in water. " C 7954 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=NC(=NC(=N1)Cl)Cl)Cl Question about this molecule: How is the solubility of this molecule Option A: It is insoluble to slightly soluble in water. Option B: It is very slightly soluble in water. Option C: It is slightly soluble in water. Option D: It is highly soluble in water. " B 7635 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(CC)COC(=O)C Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water. Option B: It is readily soluble in water. Option C: It is practically insoluble in water. Option D: It is soluble in water. " A 6544 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=O)CC(C1)(C)C Question about this molecule: How is the solubility of this molecule Option A: They readily dissolve in water. Option B: It will dissolve in water. Option C: It is dissolved in water. Option D: It can be dissolved in water. " D 62329 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=C(C(=C1[N+](=O)[O-])C(C)(C)C)[N+](=O)[O-])C)[N+](=O)[O-] Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is practically insoluble in water. Option C: It is soluble in water. Option D: It is insoluble in water. " D 9864 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(#N)N Question about this molecule: How is the solubility of this molecule Option A: It is poorly soluble in water. Option B: It is quite soluble in water. Option C: It is readily soluble in water. Option D: It is highly soluble in water. " B 8607 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=O)N(C2=O)SC(Cl)(Cl)Cl Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is readily soluble in water. Option C: It is insoluble in water. Option D: It is soluble in water. " C 6354 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CO1 Question about this molecule: How is the solubility of this molecule Option A: It sinks in water. Option B: It dissolves easily in water. Option C: It will dissolve in water. Option D: They readily dissolve in water. " B 16850 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=O)OC23C4=C(C=C(C=C4)O)OC5=C3C=CC(=C5)O Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is soluble in water. Option C: It is readily soluble in water. Option D: It is insoluble in water. " D 3030 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C=CC(=C1C(=O)O)Cl)Cl Question about this molecule: How is the solubility of this molecule Option A: It is a water-soluble, white crystalline solid compound consisting of hydrogen peroxide and urea. Option B: It is slightly soluble in water and soluble in organic solvents. Option C: It is soluble in water, alcohols, and ether. Option D: It is a white solid dissolved in a liquid carrier. " D 7047 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC=N2 Question about this molecule: How is the solubility of this molecule Option A: It is only slightly soluble in cold water but dissolves readily in hot water and most organic solvents. Option B: It is slightly soluble in water and floats on water. Option C: It is very soluble in most polar organic solvents, as well as in water. Option D: It is very slightly soluble in water and soluble in organic solvents. " A 31276 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CCOC(=O)C Question about this molecule: How is the solubility of this molecule Option A: Floats and mixes with water. Option B: It readily mixes with water. Option C: It sinks in and mixes with water. Option D: It floats and mixes with water. " A 11430 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)([O-])[O-].[K+].[K+] Question about this molecule: How is the solubility of this molecule Option A: It is very slightly soluble in water and soluble in organic solvents. Option B: It is only slightly soluble in cold water but dissolves readily in hot water and most organic solvents. Option C: It is soluble in water (insoluble in ethanol) and forms a strongly alkaline solution. Option D: It is very soluble in most polar organic solvents, as well as in water. " C 7847 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC=O Question about this molecule: How is the solubility of this molecule Option A: It does not dissolve in water very easily. Option B: It dissolves only slightly in water. Option C: It does not dissolve easily in water. Option D: It dissolves in water very easily. " D 2723790 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=S)(N)N Question about this molecule: How is the solubility of this molecule Option A: It sinks and mixes with water. Option B: It mixes with water. Option C: Sinks and mixes with water. Option D: It sinks in and mixes with water. " C 7362 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=COC(=C1)C=O Question about this molecule: How is the solubility of this molecule Option A: It is soluble in boiling water. Option B: It is practically insoluble in water. Option C: It is soluble in water. Option D: It is readily soluble in water. " C 637090 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C=C/C(=O)O Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is practically insoluble in water. Option C: It is readily soluble in water. Option D: It is soluble in boiling water. " A 5569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN(CCC)C1=C(C=C(C=C1[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-] Question about this molecule: How is the solubility of this molecule Option A: Not soluble in water. Option B: It is poorly soluble in water. Option C: It is highly soluble in water. Option D: Not very soluble in water " A 13387 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CCCC1=O Question about this molecule: How is the solubility of this molecule Option A: It completely mixes with water. Option B: It is miscible in water. Option C: It is miscible with water. Option D: It is miscible in most organic solvents. " C 10800 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC(=C1O)[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: How is the solubility of this molecule Option A: It is very soluble in most polar organic solvents, as well as in water. Option B: It is slightly soluble in water and soluble in organic solvents. Option C: It is soluble in alcohol, acetone, ether and solutions of sodium or potassium hydroxides. Option D: It is soluble in water, alcohols, and ether. " C 7570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CC2=CC=C(C=C2)N=C=O)N=C=O Question about this molecule: How is the solubility of this molecule Option A: Not very soluble in water Option B: It is highly soluble in water. Option C: Not soluble in water. Option D: It is poorly soluble in water. " C 169132 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(CC(CC(C1)(C)CN=C=O)N=C=O)C Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is insoluble in water. Option C: It is readily soluble in water. Option D: It is soluble in water. " B 11715 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)CBr Question about this molecule: How is the solubility of this molecule Option A: It is quite soluble in water. Option B: It is poorly soluble in water. Option C: It is highly soluble in water. Option D: It is readily soluble in water. " B 7775 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC(=O)OCC(C)C Question about this molecule: How is the solubility of this molecule Option A: Not soluble in water. Option B: It is poorly soluble in water. Option C: Not very soluble in water Option D: It is highly soluble in water. " A 712 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=O Question about this molecule: How is the solubility of this molecule Option A: It is soluble in boiling water. Option B: It is readily soluble in water. Option C: It is soluble in water. Option D: It is practically insoluble in water. " B 23969 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [AsH3] Question about this molecule: How is the solubility of this molecule Option A: It is water soluble. Option B: It is fat soluble. Option C: It is slightly soluble in water. Option D: It is slightly water soluble. " A 3032297 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CNC(=S)[S-])NC(=S)[S-].[Na+].[Na+] Question about this molecule: How is the solubility of this molecule Option A: It sinks in and mixes with water. Option B: It sinks and mixes with water. Option C: It readily mixes with water. Option D: It mixes with water. " D 1489 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1Cl)Cl)OCCCC(=O)O Question about this molecule: How is the solubility of this molecule Option A: It is soluble in most organic liquids. Option B: It is soluble in organic solvents. Option C: It is moderately soluble in most organic solvents. Option D: It is moderately soluble in organic solvents. " B 7577 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CC2=CC=C(C=C2)N)N Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is readily soluble in water. Option C: It is insoluble in water. Option D: It is soluble in water. " C 31253 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCCC(=C)C=C)C Question about this molecule: How is the solubility of this molecule Option A: It is less dense than water and insoluble in water. Option B: It is less dense than water and soluble in water. Option C: It is soluble in water and less dense than water. Option D: It is insoluble in water and less dense than water. " D 24404 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: P Question about this molecule: How is the solubility of this molecule Option A: It is insoluble to slightly soluble in water. Option B: It is highly soluble in water. Option C: It is very slightly soluble in water. Option D: It is slightly soluble in water. " D 784 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OO Question about this molecule: How is the solubility of this molecule Option A: They readily dissolve in water. Option B: It can be dissolved in water. Option C: It will dissolve in water. Option D: It is dissolved in water. " D 7504 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)CN Question about this molecule: How is the solubility of this molecule Option A: It sinks in and mixes with water. Option B: It floats and mixes with water. Option C: It readily mixes with water. Option D: It sinks and mixes with water. " B 5161 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)C(=O)OC2=CC=CC=C2C(=O)O)O Question about this molecule: How is the solubility of this molecule Option A: It is soluble in most organic liquids. Option B: It is moderately soluble in organic solvents. Option C: It is readily soluble in the small intestine. Option D: It is soluble in organic solvents. " C 7895 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(=O)C Question about this molecule: How is the solubility of this molecule Option A: It is less dense than water and soluble in water. Option B: It is soluble in water and less dense than water. Option C: It is insoluble in water and less dense than water. Option D: It is less dense than water and insoluble in water. " A 7368 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(F)(F)F Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water and slightly denser than water. Option B: It is insoluble in water and denser than water. Option C: It is slightly soluble in water and denser than water. Option D: It is generally denser than water and insoluble in water. " A 23665760 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]Cl.[Na+] Question about this molecule: How is the solubility of this molecule Option A: It sinks in and mixes with water. Option B: It sinks and mixes with water. Option C: It readily mixes with water. Option D: It mixes with water. " D 9253 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCCC1 Question about this molecule: How is the solubility of this molecule Option A: It is less dense than water and soluble in water. Option B: It is insoluble in water and less dense than water. Option C: It is less dense than water and insoluble in water. Option D: It is soluble in water and less dense than water. " C 31289 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCC=O Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is practically insoluble in water. Option C: It is readily soluble in water. Option D: It is insoluble in water. " D 25516 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [NH4+].[F-] Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is soluble in water. Option C: It is readily soluble in water. Option D: It is soluble in boiling water. " B 5144 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCC1=CC2=C(C=C1)OCO2 Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water and slightly denser than water. Option B: It is denser than water and insoluble in water. Option C: It is generally denser than water and insoluble in water. Option D: It is insoluble in water and denser than water. " B 6129 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC(=O)OC1=CC=CC2=CC=CC=C21 Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is practically insoluble in water. Option C: It is soluble in water. Option D: It is insoluble in water. " D 7095 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2=CC=CC=C2 Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is readily soluble in water. Option C: It is insoluble in water. Option D: It is soluble in water. " C 4093 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=C)C(=O)O Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is soluble in boiling water. Option C: It is soluble in water. Option D: It is practically insoluble in water. " C 516951 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OP(=O)(O)[O-].[K+] Question about this molecule: How is the solubility of this molecule Option A: It is soluble. Option B: It is soluble in boiling water. Option C: It is readily soluble in water. Option D: It is soluble in water. " A 8091 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCC(=O)OC Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is practically insoluble in water. Option C: It is insoluble in water. Option D: It is soluble in water. " C 8846 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOC(=O)C=C Question about this molecule: How is the solubility of this molecule Option A: It is slightly soluble in water. Option B: It is insoluble to slightly soluble in water. Option C: It is highly soluble in water. Option D: It is very slightly soluble in water. " D 6386 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)O Question about this molecule: How is the solubility of this molecule Option A: It floats and mixes with water. Option B: It sinks and mixes with water. Option C: It readily mixes with water. Option D: It sinks in and mixes with water. " A 2723923 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)[O-].[NH4+] Question about this molecule: How is the solubility of this molecule Option A: It sinks in and mixes slowly with water. Option B: It sinks and mixes slowly with water. Option C: It mixes slowly with water. Option D: It sinks in and mixes with water. " B 40326 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C(C1C(=O)OCC2=CC(=CC=C2)OC3=CC=CC=C3)C=C(Cl)Cl)C Question about this molecule: How is the solubility of this molecule Option A: It is relatively water insoluble. Option B: It is water insoluble. Option C: It is insoluble in water. Option D: It is practically insoluble in water. " A 8030 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CSC=C1 Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is readily soluble in water. Option C: It is practically insoluble in water. Option D: It is insoluble in water. " D 12589 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC[N+](=O)[O-] Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is insoluble in water. Option C: It is readily soluble in water. Option D: It is practically insoluble in water. " B 22311 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CCC(CC1)C(=C)C Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is practically insoluble in water. Option C: It is insoluble in water. Option D: It is readily soluble in water. " C 25154 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N+](=O)([O-])[O-].[N+](=O)([O-])[O-].[Cd+2] Question about this molecule: How is the solubility of this molecule Option A: It dissolves easily in water. Option B: It will dissolve in water. Option C: It sinks in water. Option D: They readily dissolve in water. " C 5360835 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Ga] Question about this molecule: How is the solubility of this molecule Option A: It is soluble in most acids and alkalis. Option B: It is moderately soluble in organic solvents. Option C: It is soluble in organic solvents. Option D: It is soluble in most organic liquids. " A 3423265 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCOS(=O)(=O)[O-].[Na+] Question about this molecule: How is the solubility of this molecule Option A: It sinks in and mixes with water. Option B: It mixes with water. Option C: It sinks and mixes with water. Option D: It readily mixes with water. " C 11761 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=CC=C1)[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is soluble in water. Option C: It is insoluble in water. Option D: It is readily soluble in water. " C 56841936 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is soluble in water. Option C: It is readily soluble in water. Option D: It is insoluble in water. " D 444539 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)/C=C/C(=O)O Question about this molecule: How is the solubility of this molecule Option A: It is highly soluble in water. Option B: It is very slightly soluble in water. Option C: It is slightly soluble in water. Option D: It is insoluble to slightly soluble in water. " C 5971 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCN=C=S Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is soluble in water. Option C: It is readily soluble in water. Option D: It is insoluble in water. " D 7964 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)Cl Question about this molecule: How is the solubility of this molecule Option A: It sinks in and mixes with water. Option B: It readily evaporates into air. Option C: It readily mixes with water. Option D: It sinks and mixes with water. " B 7485 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is soluble in water. Option C: It is insoluble in water. Option D: It is readily soluble in water. " C 444266 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=C\\C(=O)O)\\C(=O)O Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is soluble in water. Option C: It is soluble in boiling water. Option D: It is readily soluble in water. " B 996 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)O Question about this molecule: How is the solubility of this molecule Option A: It dissolves only slightly in water. Option B: It dissolves easily in water. Option C: It dissolves slightly in water. Option D: A moderate amount can form a solution with water. " D 5340 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1N)S(=O)(=O)NC2=NC=CS2 Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is practically insoluble in water. Option C: It is insoluble in water. Option D: It is soluble in water. " C 7410 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C1=CC=CC=C1 Question about this molecule: How is the solubility of this molecule Option A: It is highly soluble in water. Option B: It is insoluble to slightly soluble in water. Option C: It is very slightly soluble in water. Option D: It is slightly soluble in water. " D 213021 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=NC#N)N(C)CC1=CN=C(C=C1)Cl Question about this molecule: How is the solubility of this molecule Option A: Most neonicotinoids are water-soluble. Option B: It forms colorless crystals that are readily soluble in most organic solvents. Option C: It is moderately soluble in most organic solvents. Option D: It is moderately soluble in organic solvents. " A 6497 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COS(=O)(=O)OC Question about this molecule: How is the solubility of this molecule Option A: It is slightly soluble in water. Option B: It is insoluble to slightly soluble in water. Option C: It is very slightly soluble in water. Option D: It is highly soluble in water. " A 6654 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CCC2CC1C2(C)C Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water. Option B: It is soluble in water. Option C: It is readily soluble in water. Option D: It is practically insoluble in water. " A 8881 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCl)CCl Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is practically insoluble in water. Option C: It is insoluble in water. Option D: It is readily soluble in water. " C 3310889 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1NN)[N+](=O)[O-] Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is insoluble in water. Option C: It is soluble in water. Option D: It is practically insoluble in water. " B 8082 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCNCC1 Question about this molecule: How is the solubility of this molecule Option A: It completely mixes with water. Option B: It is miscible in most organic solvents. Option C: It is miscible in water. Option D: It is miscible with water. " C 6953 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1[N+](=O)[O-])Cl)[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: How is the solubility of this molecule Option A: It is soluble in alcohol, acetone, ether and solutions of sodium or potassium hydroxides. Option B: It is soluble in water, ethyl alcohol, and diethyl ether. Option C: Slightly soluble in ether, alcohol, and benzene. Option D: It is soluble in water, alcohols, and ether. " C 522689 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [F-].[K+] Question about this molecule: How is the solubility of this molecule Option A: It possesses poor aqueous solubility. Option B: It has a low aqueous solubility. Option C: Shipped as a solid or an aqueous solution. Option D: It has low aqueous solubility. " C 6591 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)Cl)(Cl)Cl Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is soluble in water. Option C: It is insoluble in water. Option D: It is readily soluble in water. " C 638011 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CCC/C(=C/C=O)/C)C Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is soluble in water. Option C: It is insoluble in water. Option D: It is readily soluble in water. " C 7019 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=C3C=CC=CC3=N2)N Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water and insoluble in alcohol. Option B: Free soluble in alcohol. Option C: It is freely soluble in water and practically insoluble in alcohol. Option D: It is insoluble in water and partially soluble in alcohol. " B 8184 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCO Question about this molecule: How is the solubility of this molecule Option A: It is very slightly soluble in water. Option B: It is highly soluble in water. Option C: It is slightly soluble in water. Option D: It is insoluble to slightly soluble in water. " C 6511 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[Pb](CC)(CC)CC Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is readily soluble in water. Option C: It is soluble in water. Option D: It is insoluble in water. " D 1130 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(SC=[N+]1CC2=CN=C(N=C2N)C)CCO Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water and soluble in alcohols and oils. Option B: It is freely soluble in water and practically insoluble in alcohol. Option C: It is insoluble in water and partially soluble in alcohol. Option D: It is soluble in water and insoluble in alcohol. " D 15450 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CCCCCO Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is practically insoluble in water. Option C: It is readily soluble in water. Option D: It is insoluble in water. " D 3314 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C=CC(=C1)CC=C)O Question about this molecule: How is the solubility of this molecule Option A: It is slightly soluble in water and soluble in organic solvents. Option B: Insoluble in water, but often formulated as a wettable powder. Option C: It dissolves readily in water to form flammable corrosive solutions. Option D: It is very soluble in pure water, but will become soluble if the aqueous solution is acidic due to formation of ammonium salts, as usual for organic amines. " A 1030 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CO)O Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water, alcohols, and ether. Option B: It is soluble in alcohol, acetone, ether and solutions of sodium or potassium hydroxides. Option C: It is soluble in water (insoluble in ethanol) and forms a strongly alkaline solution. Option D: It is soluble in water, acetone, and chloroform. " D 7261 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)N)N Question about this molecule: How is the solubility of this molecule Option A: It is insoluble to slightly soluble in water. Option B: It is highly soluble in water. Option C: It is slightly soluble in water. Option D: It is very slightly soluble in water. " C 180 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C Question about this molecule: How is the solubility of this molecule Option A: They readily dissolve in water. Option B: It will dissolve in water. Option C: It dissolves easily in water. Option D: It dissolves in water " D 8268 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C(C2=CC=C(C=C2)Cl)(C(Cl)(Cl)Cl)O)Cl Question about this molecule: How is the solubility of this molecule Option A: It will dissolve in water. Option B: It can be dissolved in water. Option C: They readily dissolve in water. Option D: It is dissolved in water. " D 3289 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCSP(=O)(OCC)SCCC Question about this molecule: How is the solubility of this molecule Option A: It is slightly water soluble. Option B: It may or may not be water soluble. Option C: It is water soluble. Option D: It is slightly soluble in water. " B 8130 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCC=O Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is readily soluble in water. Option C: It is insoluble in water. Option D: It is soluble in water. " C 24947 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: Cl[Cd]Cl Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is readily soluble in water. Option C: It is soluble in water. Option D: It is soluble in boiling water. " C 5364509 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCC/C=C\\CCCCCCCC(=O)OC Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water. Option B: It is soluble in water. Option C: It is readily soluble in water. Option D: It is practically insoluble in water. " A 8141 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCC Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is readily soluble in water. Option C: It is practically insoluble in water. Option D: It is insoluble in water. " D 22985 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [NH4+].[N+](=O)([O-])[O-] Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is readily soluble in water. Option C: It is practically insoluble in water. Option D: It is soluble in boiling water. " A 1140 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1 Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water. Option B: It is practically insoluble in water. Option C: It is readily soluble in water. Option D: It is soluble in water. " A 5994 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is insoluble in water. Option C: It is soluble in water. Option D: It is practically insoluble in water. " B 6561 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C=O Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is practically insoluble in water. Option C: It is readily soluble in water. Option D: It is insoluble in water. " D 992 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=C(C(=C(C(=C1Cl)Cl)Cl)Cl)Cl)O Question about this molecule: How is the solubility of this molecule Option A: It dissolves easily in water. Option B: It sinks in water. Option C: They readily dissolve in water. Option D: It will dissolve in water. " A 935 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Ni] Question about this molecule: How is the solubility of this molecule Option A: Many compounds dissolve fairly easy in water. Option B: It does not mix well with water Option C: It does not dissolve in water very easily. Option D: It does not dissolve easily in water. " A 9740 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C#N)C(=O)O Question about this molecule: How is the solubility of this molecule Option A: It mixes with water. Option B: It sinks in and mixes with water. Option C: It readily mixes with water. Option D: It sinks and mixes with water. " D 5801 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)N)O Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is readily soluble in water. Option C: It is soluble in boiling water. Option D: It is practically insoluble in water. " A 2482 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOC(=O)C1=CC=C(C=C1)N Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is insoluble in water. Option C: It is readily soluble in water. Option D: It is practically insoluble in water. " B 213032 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C(=O)N(C(=O)O1)NC2=CC=CC=C2)C3=CC=C(C=C3)OC4=CC=CC=C4 Question about this molecule: How is the solubility of this molecule Option A: It has low aqueous solubility. Option B: It has a low aqueous solubility, low risk of leaching to groundwater, and is non-volatile. Option C: It has a low aqueous solubility. Option D: It has low aqueous solubility and is not expected to leach to groundwater. " B 7242 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1N Question about this molecule: How is the solubility of this molecule Option A: It is slightly soluble in water and soluble in organic solvents. Option B: It dissolves readily in water to form flammable corrosive solutions. Option C: It is very soluble in pure water, but will become soluble if the aqueous solution is acidic due to formation of ammonium salts, as usual for organic amines. Option D: Insoluble in water, but often formulated as a wettable powder. " C 24450 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OP(=O)([O-])[O-].[K+].[K+] Question about this molecule: How is the solubility of this molecule Option A: It dissolves readily in water to form flammable corrosive solutions. Option B: It is very soluble in pure water, but will become soluble if the aqueous solution is acidic due to formation of ammonium salts, as usual for organic amines. Option C: It is a highly water-soluble salt often used as a fertilizer and food additive as a source of phosphorus and potassium as well as a buffering agent. Option D: Insoluble in water, but often formulated as a wettable powder. " C 246728 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC(=O)CC Question about this molecule: How is the solubility of this molecule Option A: It is freely soluble in water and practically insoluble in alcohol. Option B: It is insoluble in water and partially soluble in alcohol. Option C: It is soluble in water and insoluble in alcohol. Option D: It is insoluble in water and soluble in alcohols and oils. " B 3283 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOCC Question about this molecule: How is the solubility of this molecule Option A: It is slightly soluble in water. Option B: It is very slightly soluble in water. Option C: It is insoluble to slightly soluble in water. Option D: It is highly soluble in water. " A 8892 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC(=O)O Question about this molecule: How is the solubility of this molecule Option A: It is highly soluble in water. Option B: It is insoluble to slightly soluble in water. Option C: It is slightly soluble in water. Option D: It is very slightly soluble in water. " B 47491 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NC(=NC(=N1)OC)NC(=O)NS(=O)(=O)C2=CC=CC=C2Cl Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is practically insoluble in water. Option C: It is readily soluble in water. Option D: It is insoluble in water. " D 6564 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CCl)Cl Question about this molecule: How is the solubility of this molecule Option A: It is highly soluble in water. Option B: It is poorly soluble in water. Option C: It is minimally soluble in water. Option D: It is moderately soluble in water. " D 104770 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]Cl(=O)=O Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is readily soluble in water. Option C: It is soluble in boiling water. Option D: It is soluble in water. " D 6849 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC=C2[N+](=O)[O-] Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water. Option B: It is readily soluble in water. Option C: It is soluble in water. Option D: It is practically insoluble in water. " A 24502 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-][Cr](=O)(=O)O[Cr](=O)(=O)[O-].[K+].[K+] Question about this molecule: How is the solubility of this molecule Option A: It is soluble in boiling water. Option B: It is readily soluble in water. Option C: It is practically insoluble in water. Option D: It is soluble in water. " D 14213 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(=O)[O-])[O-].[NH4+].[NH4+] Question about this molecule: How is the solubility of this molecule Option A: It mixes slowly with water. Option B: It sinks in and mixes slowly with water. Option C: It sinks and mixes slowly with water. Option D: It sinks in and mixes with water. " C 4169 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC1=CC=CC(=C1N(C(C)COC)C(=O)CCl)C Question about this molecule: How is the solubility of this molecule Option A: It is slightly soluble in water. Option B: It is very slightly soluble in water. Option C: It is insoluble to slightly soluble in water. Option D: It is highly soluble in water. " A 6337 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCl Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is soluble in water. Option C: It is insoluble in water. Option D: It is practically insoluble in water. " C 5780 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@H]([C@H]([C@@H]([C@H](CO)O)O)O)O)O Question about this molecule: How is the solubility of this molecule Option A: It sinks in and mixes with water. Option B: It mixes with water. Option C: It sinks and mixes with water. Option D: It readily mixes with water. " C 6781 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C1=CC=CC=C1C(=O)OCC Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is practically insoluble in water. Option C: It is insoluble in water. Option D: It is soluble in water. " C 7515 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC1=CC=CC=C1 Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is insoluble in water. Option C: It is soluble in water. Option D: It is readily soluble in water. " B 8003 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is readily soluble in water. Option C: It is soluble in water. Option D: It is insoluble in water. " D 8530 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=O)C=CC(=O)C2=C1 Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water, alcohols, and ether. Option B: Slightly soluble in ether, alcohol, and benzene. Option C: It is soluble in alcohol, acetone, ether and solutions of sodium or potassium hydroxides. Option D: Slightly soluble in petroleum ether. " D 18502 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(CC1)N=C=O Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water. Option B: It is practically insoluble in water. Option C: It is soluble in water. Option D: It is readily soluble in water. " A 6422 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(F)(F)F)O Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is readily soluble in water. Option C: It is practically insoluble in water. Option D: It is soluble in boiling water. " A 8174 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCO Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water. Option B: It is readily soluble in water. Option C: It is soluble in water. Option D: It is practically insoluble in water. " A 152119 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OP(=S)(O)S Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is insoluble in water. Option C: It is soluble in water. Option D: It is practically insoluble in water. " B 7855 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC#N Question about this molecule: How is the solubility of this molecule Option A: It will dissolve in water. Option B: It can be dissolved in water. Option C: They readily dissolve in water. Option D: It is dissolved in water. " B 24814 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: Cl[Sb](Cl)Cl Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water. Option B: It is soluble in water. Option C: It is readily soluble in water. Option D: It is practically insoluble in water. " A 6375 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+](=O)[O-] Question about this molecule: How is the solubility of this molecule Option A: It is insoluble to slightly soluble in water. Option B: It is highly soluble in water. Option C: It is very slightly soluble in water. Option D: It is slightly soluble in water. " D 8150 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCOCCOC Question about this molecule: How is the solubility of this molecule Option A: It sinks in and mixes with water. Option B: It sinks and mixes with water. Option C: It floats and mixes with water. Option D: It readily mixes with water. " C 174 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CO)O Question about this molecule: How is the solubility of this molecule Option A: It easily penetrates the soil and contaminates groundwater and nearby streams. Option B: It is slightly soluble in water and soluble in organic solvents. Option C: It is very soluble in pure water, but will become soluble if the aqueous solution is acidic due to formation of ammonium salts, as usual for organic amines. Option D: It is soluble in water, alcohols, and ether. " A 10178 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C1=C(C=C(C=C1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: How is the solubility of this molecule Option A: It dissolves only slightly in water. Option B: It dissolves slightly in water. Option C: It dissolves slightly in water and in other liquids. Option D: It dissolves easily in water. " C 8078 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCCCC1 Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is practically insoluble in water. Option C: It is readily soluble in water. Option D: It is insoluble in water. " D 6944 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1[N+](=O)[O-] Question about this molecule: How is the solubility of this molecule Option A: It dissolves easily in water. Option B: They readily dissolve in water. Option C: It sinks in water. Option D: It will dissolve in water. " C 5206 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(OC(C(F)(F)F)C(F)(F)F)F Question about this molecule: How is the solubility of this molecule Option A: It has a high level of solubility. Option B: It has a low solubility profile. Option C: It has a low aqueous solubility. Option D: It has low aqueous solubility. " B 8086 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CNCC(C)O)O Question about this molecule: How is the solubility of this molecule Option A: It sinks and mixes in water. Option B: It readily mixes with water. Option C: It sinks and mixes with water. Option D: It sinks in and mixes with water. " A 300 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)O)Cl Question about this molecule: How is the solubility of this molecule Option A: It is soluble in boiling water. Option B: It is readily soluble in water. Option C: It is soluble in water and sinks in water. Option D: It is soluble in water. " C 21013 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=C(C(=C1Cl)Cl)Cl)Cl)O Question about this molecule: How is the solubility of this molecule Option A: It is insoluble to slightly soluble in water. Option B: It is highly soluble in water. Option C: It is very slightly soluble in water. Option D: It is slightly soluble in water. " D 3024 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Br)Br Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is insoluble in water. Option C: It is readily soluble in water. Option D: It is soluble in water. " B 10112 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)([O-])[O-].[Ca+2] Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is soluble in water. Option C: It is practically insoluble in water. Option D: It is insoluble in water. " C 62672 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Be+2].O.O.O.O.[O-]S(=O)(=O)[O-] Question about this molecule: How is the solubility of this molecule Option A: It dissolves easily in water. Option B: They readily dissolve in water. Option C: It sinks in water and dissolves. Option D: It sinks and dissolves in water. " C 7416 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: How is the solubility of this molecule Option A: It dissolves slightly in water. Option B: It dissolves easily in water. Option C: It dissolves only slightly in water. Option D: They readily dissolve in water. " C 9584 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)N)F Question about this molecule: How is the solubility of this molecule Option A: It mixes slowly with water. Option B: It sinks and mixes slowly with water. Option C: It sinks in and mixes slowly with water. Option D: It sinks in and mixes with water. " C 7848 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCS Question about this molecule: How is the solubility of this molecule Option A: It is slightly soluble in water. Option B: It is very slightly soluble in water. Option C: It is insoluble to slightly soluble in water. Option D: It is highly soluble in water. " A 460 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC=CC=C1O Question about this molecule: How is the solubility of this molecule Option A: It is slightly water soluble. Option B: It is fat soluble. Option C: It is slightly soluble in water. Option D: It is water soluble. " A 24965 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]S(=O)(=O)[O-].[Co+2] Question about this molecule: How is the solubility of this molecule Option A: It sinks in and mixes with water. Option B: It mixes with water. Option C: It readily mixes with water. Option D: It sinks and mixes with water. " D 11137 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC(=C1)O)[N+](=O)[O-] Question about this molecule: How is the solubility of this molecule Option A: It sinks in and mixes with water. Option B: It sinks and mixes with water. Option C: It readily mixes with water. Option D: It mixes with water. " A 7092 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC2=C(C=C1)OC(=O)C=C2 Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is insoluble in water. Option C: It is readily soluble in water. Option D: It is practically insoluble in water. " B 342 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC=C1)O Question about this molecule: How is the solubility of this molecule Option A: It sinks in and mixes slowly with water. Option B: It sinks and mixes slowly with water. Option C: It sinks in and mixes with water. Option D: It mixes slowly with water. " B 5943 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)(Cl)(Cl)Cl Question about this molecule: How is the solubility of this molecule Option A: It does not mix well with water Option B: It doesn't dissolve easily in water. Option C: It does not dissolve in water very easily. Option D: It does not dissolve easily in water. " C 338 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)C(=O)O)O Question about this molecule: How is the solubility of this molecule Option A: It mixes slowly with water. Option B: It sinks and mixes slowly with water. Option C: It sinks in and mixes with water. Option D: It sinks in and mixes slowly with water. " B 1118 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OS(=O)(=O)O Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is soluble in water at all concentrations. Option C: It is soluble in boiling water. Option D: It is readily soluble in water. " B 7505 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C#N Question about this molecule: How is the solubility of this molecule Option A: It is very slightly soluble in water. Option B: It is insoluble to slightly soluble in water. Option C: It is slightly soluble in water. Option D: It is highly soluble in water. " C 6115 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)N Question about this molecule: How is the solubility of this molecule Option A: It is slightly soluble in water. Option B: It is very slightly soluble in water. Option C: It is insoluble to slightly soluble in water. Option D: It is highly soluble in water. " A 8134 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCOCCO Question about this molecule: How is the solubility of this molecule Option A: It floats and mixes with water. Option B: It sinks in and mixes with water. Option C: It sinks and mixes with water. Option D: It readily mixes with water. " A 14855 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CC(=C1)Cl)O Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is insoluble in water. Option C: It is practically insoluble in water. Option D: It is readily soluble in water. " B 3893 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCC(=O)O Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is soluble in boiling water. Option C: It is soluble in water. Option D: It is practically insoluble in water. " B 454 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCC=O Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is readily soluble in water. Option C: It is soluble in water. Option D: It is insoluble in water. " D 8640 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC=C2N Question about this molecule: How is the solubility of this molecule Option A: It is slightly soluble in water and denser than water. Option B: It is generally denser than water and insoluble in water. Option C: It is insoluble in water and slightly denser than water. Option D: It is insoluble in water and denser than water. " D 971 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(=O)O)O Question about this molecule: How is the solubility of this molecule Option A: It sinks in water and dissolves. Option B: It dissolves in water to give colorless, acidic solutions. Option C: It dissolves easily in water. Option D: It sinks and dissolves in water. " B 6623 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C1=CC=C(C=C1)O)C2=CC=C(C=C2)O Question about this molecule: How is the solubility of this molecule Option A: It will dissolve in water. Option B: They readily dissolve in water. Option C: It sinks in water. Option D: It dissolves easily in water. " C 1570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=S)N(C=C1)O Question about this molecule: How is the solubility of this molecule Option A: It has a low solubility profile. Option B: It has low aqueous solubility. Option C: It has low solubility. Option D: It has a low aqueous solubility. " C 7966 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(CC1)O Question about this molecule: How is the solubility of this molecule Option A: It is soluble in most organic liquids. Option B: It is soluble in organic solvents. Option C: It is moderately soluble in most organic solvents. Option D: It is moderately soluble in organic solvents. " A 125468 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C=C(\\C)/C(=O)O Question about this molecule: How is the solubility of this molecule Option A: It is insoluble to slightly soluble in water. Option B: It is very slightly soluble in water. Option C: It is highly soluble in water. Option D: It is slightly soluble in water. " D 9570071 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(/C=N/OC(=O)NC)SC Question about this molecule: How is the solubility of this molecule Option A: It has a high level of solubility. Option B: It has low aqueous solubility. Option C: It has a low aqueous solubility. Option D: It has a low solubility profile. " A 240 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C=O Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is insoluble in water. Option C: It is readily soluble in water. Option D: It is practically insoluble in water. " B 23677060 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O[As](=O)(O)[O-].[Na+] Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is soluble in water. Option C: It is practically insoluble in water. Option D: It is soluble in boiling water. " B 931 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C=CC=CC2=C1 Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is insoluble in water. Option C: It is readily soluble in water. Option D: It is practically insoluble in water. " B 222 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: N Question about this molecule: How is the solubility of this molecule Option A: It is dissolved in water. Option B: It can be dissolved in water. Option C: It will dissolve in water. Option D: They readily dissolve in water. " B 7638 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)COC2=CC=C(C=C2)O Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is soluble in water. Option C: It is insoluble in water. Option D: It is practically insoluble in water. " D 4420 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=O)(OC)OC(C(Cl)(Cl)Br)Br Question about this molecule: How is the solubility of this molecule Option A: It is soluble in organic solvents. Option B: It is moderately soluble in organic solvents. Option C: It can be dissolved in a liquid organic carrier. Option D: It is soluble in most organic liquids. " C 6294 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is readily soluble in water. Option C: It is insoluble in water. Option D: It is practically insoluble in water. " C 7839 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CBr)Br Question about this molecule: How is the solubility of this molecule Option A: It is highly soluble in water. Option B: It is insoluble to slightly soluble in water. Option C: It is very slightly soluble in water. Option D: It is slightly soluble in water. " D 1057 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C(=C1)O)O)O Question about this molecule: How is the solubility of this molecule Option A: It can mix with water. Option B: It sinks in and mixes with water. Option C: It sinks and mixes with water. Option D: It mixes with water. " A 5238 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Na+].[I-] Question about this molecule: How is the solubility of this molecule Option A: They are water-soluble. Option B: It is insoluble in water. Option C: It is water-soluble. Option D: It is water insoluble. " C 8063 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC=O Question about this molecule: How is the solubility of this molecule Option A: It is highly soluble in water. Option B: It is insoluble to slightly soluble in water. Option C: It is very slightly soluble in water. Option D: It is slightly soluble in water. " D 10917 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+](C)(C)C[C@@H](CC(=O)[O-])O Question about this molecule: How is the solubility of this molecule Option A: It is very soluble in water Option B: It is quite soluble in water. Option C: It is highly soluble in water. Option D: It is poorly soluble in water. " A 8900 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCC Question about this molecule: How is the solubility of this molecule Option A: It is insoluble in water. Option B: It is soluble in water. Option C: It is practically insoluble in water. Option D: It is readily soluble in water. " A 6896 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=CC=C1)C)N Question about this molecule: How is the solubility of this molecule Option A: It is insoluble to slightly soluble in water. Option B: It is highly soluble in water. Option C: It is slightly soluble in water. Option D: It is very slightly soluble in water. " C 2682 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCCCCCO Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water and insoluble in alcohol. Option B: It is freely soluble in water and practically insoluble in alcohol. Option C: It is insoluble in water and partially soluble in alcohol. Option D: It is insoluble in water and soluble in alcohols and oils. " D 8452 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(=O)C1 Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is practically insoluble in water. Option C: It is readily soluble in water. Option D: It is insoluble in water. " D 53518 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C(C)OC1=CC=C(C=C1)OC2=CN=C3C=C(C=CC3=N2)Cl Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is insoluble in water. Option C: It is readily soluble in water. Option D: It is practically insoluble in water. " B 8496 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC(=C1)C(=O)O)C(=O)O Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is practically insoluble in water. Option C: It is readily soluble in water. Option D: It is insoluble in water. " D 7628 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: B(O)(O)O Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is soluble in water. Option C: It is readily soluble in water. Option D: It is soluble in boiling water. " B 7452 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC(=C1)[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: How is the solubility of this molecule Option A: It is soluble in water. Option B: It is practically insoluble in water. Option C: It is insoluble in water. Option D: It is readily soluble in water. " C 5333 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1N)S(=O)(=O)N Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is soluble in boiling water. Option C: It is soluble in water. Option D: It is practically insoluble in water. " C 1146 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C Question about this molecule: How is the solubility of this molecule Option A: It has improved water solubility due to the replacement of chlorine ligands by oxalato bidentate. Option B: It dissolves in water to form flammable, corrosive solutions. Option C: It has a low aqueous solubility, low risk of leaching to groundwater, and is non-volatile. Option D: A 1% solution in water is slightly alkaline to litmus. " B 8051 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC(=O)C Question about this molecule: How is the solubility of this molecule Option A: It is slightly soluble in water. Option B: It is highly soluble in water. Option C: It is insoluble to slightly soluble in water. Option D: It is very slightly soluble in water. " A 3485 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC=O)CC=O Question about this molecule: How is the solubility of this molecule Option A: It sinks and mixes with water. Option B: It readily mixes with water. Option C: It sinks in and mixes with water. Option D: It mixes with water. " D 6305 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)O)N Question about this molecule: How is the solubility of this molecule Option A: It is readily soluble in water. Option B: It is insoluble in water. Option C: It is soluble in water. Option D: It is practically insoluble in water. " B 3026 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC Question about this molecule: How is the solubility of this molecule Option A: It is very slightly soluble in water. Option B: It is slightly soluble in water. Option C: It is highly soluble in water. Option D: It is insoluble to slightly soluble in water. " B 24437 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]S(=O)[O-].[Na+].[Na+] Question about this molecule: How is the solubility of this molecule Option A: It is very slightly soluble in water. Option B: It is slightly soluble in water. Option C: It is insoluble to slightly soluble in water. Option D: It is highly soluble in water. " B 2537 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C2CCC1(C(=O)C2)C)C Question about this molecule: How is the solubility of this molecule Option A: It is practically insoluble in water. Option B: It is soluble in water. Option C: It is insoluble in water. Option D: It is readily soluble in water. " C 12232 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CSSC Question about this molecule: How is the solubility of this molecule Option A: It is highly soluble in water. Option B: It is slightly soluble in water. Option C: It is insoluble to slightly soluble in water. Option D: It is very slightly soluble in water. " B 5281404 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NC=CC2=C1NC3=CC=CC=C23 Question about this molecule: Which kind of specificity does this molecule have/exhibit? Option A: It displays an intermediate specificity to target both the cardiac and vascular smooth muscle. Option B: It is a specific, reversible inhibitor of monoamine oxidase A. Option C: It acts as an inhibitor of the enzyme phospholipase A2 (EC 3.1.1.4) of insects like diamond back moth. Option D: It is a non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. " B 70678756 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C[C@@H](C(=O)NCCCNCCCCN)NC(=O)C2C(O2)C(=O)O)O Question about this molecule: Which kind of specificity does this molecule have/exhibit? Option A: It is specific for the gate-keeper T790M mutations which increases ATP binding activity to EGFR and result in poor prognosis for late-stage disease. Option B: It acts as an inhibitor of cysteine proteinases, particularly cathepsin B (EC 3.4.22.1), cathepsin L (EC 3.4.22.15), and papain (EC 3.4.22.2). Option C: It is a cell-permeable, reversible noncompetitive inhibitor of the GTPase activity of dynamin 1 and 2 and Drp1 (mitochondrial), while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. Option D: It competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV. " B 70678751 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C[C@@H](C(=O)NCCCCNCCCN)NC(=O)C2C(O2)C(=O)O)O Question about this molecule: Which kind of specificity does this molecule have/exhibit? Option A: It is a cell-permeable, reversible noncompetitive inhibitor of the GTPase activity of dynamin 1 and 2 and Drp1 (mitochondrial), while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. Option B: It is specific for the gate-keeper T790M mutations which increases ATP binding activity to EGFR and result in poor prognosis for late-stage disease. Option C: It competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV. Option D: It acts as an inhibitor of cysteine proteinases, particularly cathepsin B (EC 3.4.22.1), cathepsin L (EC 3.4.22.15), and papain (EC 3.4.22.2). " D 441386 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NC1=C(N=CC=C1)N2CCN(CC2)C(=O)C3=CC4=C(N3)C=CC(=C4)NS(=O)(=O)C.CS(=O)(=O)O Question about this molecule: Which kind of specificity does this molecule have/exhibit? Option A: It acts as an inhibitor of the enzyme phospholipase A2 (EC 3.1.1.4) of insects like diamond back moth. Option B: It is a specific, reversible inhibitor of monoamine oxidase A. Option C: It is a non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. Option D: It displays an intermediate specificity to target both the cardiac and vascular smooth muscle. " C 637759 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)/C=C/C1=CC=CC=C1 Question about this molecule: Which kind of specificity does this molecule have/exhibit? Option A: It is a specific, reversible inhibitor of monoamine oxidase A. Option B: It acts as an inhibitor of the enzyme phospholipase A2 (EC 3.1.1.4) of insects like diamond back moth. Option C: It has higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Option D: It displays an intermediate specificity to target both the cardiac and vascular smooth muscle. " B 135398508 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=C1[C@H](C[C@@H]([C@H]1CO)O)N2C=NC3=C2N=C(NC3=O)N Question about this molecule: Which kind of specificity does this molecule have/exhibit? Option A: It competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV. Option B: It reduces pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. Option C: It is specific for the gate-keeper T790M mutations which increases ATP binding activity to EGFR and result in poor prognosis for late-stage disease. Option D: It is a cell-permeable, reversible noncompetitive inhibitor of the GTPase activity of dynamin 1 and 2 and Drp1 (mitochondrial), while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. " A 2083 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)NCC(C1=CC(=C(C=C1)O)CO)O Question about this molecule: Which kind of specificity does this molecule have/exhibit? Option A: It is specific for the gate-keeper T790M mutations which increases ATP binding activity to EGFR and result in poor prognosis for late-stage disease. Option B: It has higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Option C: It reduces pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. Option D: It competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV. " B 71496458 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC Question about this molecule: Which kind of specificity does this molecule have/exhibit? Option A: It competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV. Option B: It has higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Option C: It is specific for the gate-keeper T790M mutations which increases ATP binding activity to EGFR and result in poor prognosis for late-stage disease. Option D: It reduces pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. " C 6253 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)O Question about this molecule: Which kind of specificity does this molecule have/exhibit? Option A: It displays an intermediate specificity to target both the cardiac and vascular smooth muscle. Option B: Its actions are specific for the S phase of the cell cycle. Option C: It reduces pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. Option D: It contains the biological activity that stimulates production of corticosteroids in the adrenal cortex. " B 39186 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)O[C@@H]1[C@@H](SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC Question about this molecule: Which kind of specificity does this molecule have/exhibit? Option A: It is specific for the gate-keeper T790M mutations which increases ATP binding activity to EGFR and result in poor prognosis for late-stage disease. Option B: It has higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Option C: It reduces pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. Option D: It displays an intermediate specificity to target both the cardiac and vascular smooth muscle. " D 219023 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@]1(CC(=O)OCC2=C1C=C3C4=C(CN3C2=O)C=C5C=C(C(=CC5=N4)F)F)O Question about this molecule: Which kind of stability does this molecule have/exhibit? Option A: At physiological pH, it is highly unstable, rapidly decomposing to give CO2, NO2, and hydroxyl radicals. Option B: It has greater lactone stability in plasma compared with other topoisomerase I inhibitors. Option C: It is the most abundant and stable of the 25 known radioisotopes of zinc. Option D: The oxazine ring containing the hemi-aminal group is unstable under both acidic and alkaline conditions. " B 24341 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OCl Question about this molecule: Which kind of stability does this molecule have/exhibit? Option A: At physiological pH, it is highly unstable, rapidly decomposing to give CO2, NO2, and hydroxyl radicals. Option B: It is the most abundant and stable of the 25 known radioisotopes of zinc. Option C: It has greater lactone stability in plasma compared with other topoisomerase I inhibitors. Option D: It is a weak, unstable acid. " D 53356678 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(O)OON=O Question about this molecule: Which kind of stability does this molecule have/exhibit? Option A: At physiological pH, it is highly unstable, rapidly decomposing to give CO2, NO2, and hydroxyl radicals. Option B: It is the most abundant and stable of the 25 known radioisotopes of zinc. Option C: The oxazine ring containing the hemi-aminal group is unstable under both acidic and alkaline conditions. Option D: It has greater lactone stability in plasma compared with other topoisomerase I inhibitors. " A 91574 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [65Zn] Question about this molecule: Which kind of stability does this molecule have/exhibit? Option A: The oxazine ring containing the hemi-aminal group is unstable under both acidic and alkaline conditions. Option B: It has greater lactone stability in plasma compared with other topoisomerase I inhibitors. Option C: It is the most abundant and stable of the 25 known radioisotopes of zinc. Option D: At physiological pH, it is highly unstable, rapidly decomposing to give CO2, NO2, and hydroxyl radicals. " C 5281873 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C(C1C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)/C=C(/C(F)(F)F)\\Cl)C Question about this molecule: How is the stability of this molecule Option A: It is usually broken apart by sunlight and the atmosphere in one or two days. Option B: It degrades rapidly and readily evaporates into air. Option C: They are chemically stable over a wide range of temperature and pH. Option D: They are usually broken apart by sunlight and the atmosphere in one or two days. " A 10967 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(OCCl)Cl Question about this molecule: How is the stability of this molecule Option A: It degrades rapidly and readily evaporates into air. Option B: Prolonged exposure to heat can cause the containers to rupture violently. Option C: Prolonged exposure to intense heat may cause the containers to rupture violently. Option D: Under prolonged exposure to fire or heat, the containers may explode violently. " A 6278 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(Cl)(Cl)Cl Question about this molecule: How is the stability of this molecule Option A: It is unstable with respect to dehydrochlorination and attacks some metals. Option B: It is usually broken apart by sunlight and the atmosphere in one or two days. Option C: They are chemically stable over a wide range of temperature and pH. Option D: They are usually broken apart by sunlight and the atmosphere in one or two days. " A 7845 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC=C Question about this molecule: How is the stability of this molecule Option A: Prolonged exposure to heat can cause the containers to rupture violently. Option B: Prolonged exposure to intense heat may cause the containers to rupture violently. Option C: It is a flammable gas subject to polymerization on storage. Option D: Under prolonged exposure to fire or heat, the containers may explode violently. " C 6579 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC(=O)N Question about this molecule: How is the stability of this molecule Option A: The solid is stable at room temperature. Option B: Stable at room temperature. Option C: Stable in air. Option D: It degrades rapidly and readily evaporates into air. " A 40585 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1([C@H]([C@H]1C(=O)O[C@H](C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C=C(Br)Br)C Question about this molecule: How is the stability of this molecule Option A: They are chemically stable over a wide range of temperature and pH. Option B: It degrades rapidly and readily evaporates into air. Option C: It is usually broken apart by sunlight and the atmosphere in one or two days. Option D: They are usually broken apart by sunlight and the atmosphere in one or two days. " C 6782 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)COC(=O)C1=CC=CC=C1C(=O)OCC(C)C Question about this molecule: How is the stability of this molecule Option A: It has excellent heat and light stability. Option B: It is readily degraded by exposure to light, heat, and oxygen. Option C: It is unstable, decomposing readily to oxygen and water with release of heat. Option D: Exposure to sunlight, water, and oxygen will accelerate its decomposition. " A 5976 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)N Question about this molecule: How is the stability of this molecule Option A: It is chemically stable over a wide range of temperature and pH, possibly as a result of its cyclic structure. Option B: Microcystins are chemically stable over a wide range of temperature and pH. Option C: Prolonged exposure of containers to heat may result in their violent rupturing and rocketing due to decomposition. Option D: It is stable at acidic pH but undergoes spontaneous nonenzymatic hydrolysis at neutral or slightly basic pH. " C 39985 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C(=O)OC)OC1=CC=C(C=C1)OC2=C(C=C(C=C2)Cl)Cl Question about this molecule: How is the stability of this molecule Option A: It is usually broken apart by sunlight and the atmosphere in one or two days. Option B: It degrades rapidly and readily evaporates into air. Option C: It is decomposed slowly by water. Option D: It is decomposed by either strong acid or base. " D 3000605 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CNC(=S)S)NC(=S)S Question about this molecule: How is the stability of this molecule Option A: It is unstable. Option B: They lack unstable functionality. Option C: It is a very unstable material. Option D: It is unstable in the pure form. " C 6338 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCl Question about this molecule: How is the stability of this molecule Option A: It is unstable in the pure form. Option B: It is unstable. Option C: It is less susceptible to hydrolysis. Option D: It is not stable at high temperatures. " D 48132 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1([C@H]([C@H]1C(=O)O[C@H](C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C(C(Br)(Br)Br)Br)C Question about this molecule: How is the stability of this molecule Option A: It is usually broken apart by sunlight and the atmosphere in one or two days. Option B: They are usually broken apart by sunlight and the atmosphere in one or two days. Option C: They are chemically stable over a wide range of temperature and pH. Option D: It degrades rapidly and readily evaporates into air. " A 1102 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCNCCCN)CN Question about this molecule: How is the stability of this molecule Option A: It is thought to help stabilize some membranes and nucleic acid structures. Option B: It is unstable in the pure form. Option C: Lead is a stable element. Option D: It is chemically stable. " A 6436606 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1([C@H]([C@H]1C(=O)O[C@H](C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)/C=C\\C(=O)OC(C(F)(F)F)C(F)(F)F)C Question about this molecule: How is the stability of this molecule Option A: It degrades rapidly and readily evaporates into air. Option B: They are usually broken apart by sunlight and the atmosphere in one or two days. Option C: They are chemically stable over a wide range of temperature and pH. Option D: It is usually broken apart by sunlight and the atmosphere in one or two days. " B 31236 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)OCCO Question about this molecule: How is the stability of this molecule Option A: It is unstable in the pure form. Option B: It is chemically stable. Option C: It is unstable. Option D: Lead is a stable element. " B 5281874 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=C(C(=C1F)F)COC(=O)C2C(C2(C)C)/C=C(/C(F)(F)F)\\Cl)F)F Question about this molecule: How is the stability of this molecule Option A: They are usually broken apart by sunlight and the atmosphere in one or two days. Option B: It is usually broken apart by sunlight and the atmosphere in one or two days. Option C: They are chemically stable over a wide range of temperature and pH. Option D: It degrades rapidly and readily evaporates into air. " A 38283 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CC1C(C1(C)C)C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C Question about this molecule: How is the stability of this molecule Option A: They are chemically stable over a wide range of temperature and pH. Option B: It degrades rapidly and readily evaporates into air. Option C: It is usually broken apart by sunlight and the atmosphere in one or two days. Option D: They are usually broken apart by sunlight and the atmosphere in one or two days. " D 445154 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O)O)O Question about this molecule: How is the stability of this molecule Option A: It is readily degraded by exposure to light, heat, and oxygen. Option B: Exposure to sunlight, water, and oxygen will accelerate its decomposition. Option C: Under prolonged exposure to fire or heat, the containers may explode violently. Option D: It is unstable, decomposing readily to oxygen and water with release of heat. " A 2723790 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=S)(N)N Question about this molecule: How is the stability of this molecule Option A: The intermediate of the reaction is an unstable epidioxide. Option B: It is unstable in the pure form. Option C: It is unstable. Option D: It is an extremely stable inhalation anesthetic. " A 47326 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C(C1(C)C)C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C Question about this molecule: How is the stability of this molecule Option A: They are chemically stable over a wide range of temperature and pH. Option B: It degrades rapidly and readily evaporates into air. Option C: They are usually broken apart by sunlight and the atmosphere in one or two days. Option D: It is usually broken apart by sunlight and the atmosphere in one or two days. " C 784 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OO Question about this molecule: How is the stability of this molecule Option A: Under prolonged exposure to fire or heat, the containers may explode violently. Option B: It is unstable, decomposing readily to oxygen and water with release of heat. Option C: It is readily degraded by exposure to light, heat, and oxygen. Option D: Exposure to sunlight, water, and oxygen will accelerate its decomposition. " B 61739 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]Cl Question about this molecule: How is the stability of this molecule Option A: They lack unstable functionality. Option B: It is a very unstable material. Option C: It is unstable in the pure form. Option D: It is unstable. " C 3226 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(OC(F)F)(F)F)(F)Cl Question about this molecule: How is the stability of this molecule Option A: It is unstable. Option B: It is an extremely stable inhalation anesthetic. Option C: It is unstable in the pure form. Option D: It decomposes in sunlight. " B 7846 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC#C Question about this molecule: How is the stability of this molecule Option A: Prolonged exposure of containers to heat may result in their violent rupturing and rocketing due to decomposition. Option B: Prolonged exposure to intense heat may cause the containers to rupture violently. Option C: Under prolonged exposure to fire or heat, the containers may explode violently. Option D: Prolonged exposure to heat can cause the containers to rupture violently. " B 444266 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=C\\C(=O)O)\\C(=O)O Question about this molecule: How is the stability of this molecule Option A: It is a very unstable material. Option B: The cis isomer is the less stable one of the two. Option C: It is not stable at high temperatures. Option D: It is less susceptible to hydrolysis. " B 6511 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[Pb](CC)(CC)CC Question about this molecule: How is the stability of this molecule Option A: Lead is a stable element. Option B: It is unstable in the pure form. Option C: It is chemically stable. Option D: It is unstable. " A 1130 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(SC=[N+]1CC2=CN=C(N=C2N)C)CCO Question about this molecule: How is the stability of this molecule Option A: It is unstable. Option B: It decomposes in sunlight. Option C: It is unstable in the pure form. Option D: It decomposes if heated. " D 5994 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C Question about this molecule: How is the stability of this molecule Option A: Stable at room temperature. Option B: Stable in air. Option C: The solid is stable at room temperature. Option D: It degrades rapidly and readily evaporates into air. " B 5284607 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=O)C2=CC=CC=C2C1=O)C/C=C(\\C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C Question about this molecule: How is the stability of this molecule Option A: It decomposes if heated. Option B: It is unstable. Option C: It is unstable in the pure form. Option D: It decomposes in sunlight. " D 135436526 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C(=N)N[N+](=O)[O-])N=O Question about this molecule: How is the stability of this molecule Option A: Prolonged exposure to intense heat may cause the containers to rupture violently. Option B: Prolonged exposure to heat can cause the containers to rupture violently. Option C: Under prolonged exposure to fire or heat, the containers may explode violently. Option D: May decompose during prolonged storage. " D 24814 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: Cl[Sb](Cl)Cl Question about this molecule: How is the stability of this molecule Option A: It degrades rapidly and readily evaporates into air. Option B: It is decomposed slowly by water. Option C: Prolonged exposure to heat can cause the containers to rupture violently. Option D: Prolonged exposure to intense heat may cause the containers to rupture violently. " B 6328544 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [210Po] Question about this molecule: How is the stability of this molecule Option A: They lack unstable functionality. Option B: It is unstable. Option C: It is unstable in the pure form. Option D: It is a very unstable material. " B 4075 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1N)C(=O)O)O Question about this molecule: How is the stability of this molecule Option A: It minimizes susceptibility to esterase degradation. Option B: It lacks stability as a pharmaceutical agent. Option C: Prolonged exposure to intense heat may cause the containers to rupture violently. Option D: It degrades rapidly and readily evaporates into air. " B 132971 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC=C4C5=CN=CC=C5)C)O Question about this molecule: How is the stability of this molecule Option A: It is less susceptible to hydrolysis. Option B: It is not stable at high temperatures. Option C: It is unstable. Option D: It is unstable in the pure form. " A 2912 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C(C1C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C=C(Cl)Cl)C Question about this molecule: How is the stability of this molecule Option A: It is unstable, decomposing readily to oxygen and water with release of heat. Option B: Exposure to sunlight, water, and oxygen will accelerate its decomposition. Option C: Under prolonged exposure to fire or heat, the containers may explode violently. Option D: It is readily degraded by exposure to light, heat, and oxygen. " B 11045 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1[N+](=O)[O-])S(=O)(=O)O)[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: How is the stability of this molecule Option A: Prolonged exposure of containers to heat may result in their violent rupturing and rocketing due to decomposition. Option B: Under prolonged exposure to fire or heat, the containers may explode violently. Option C: Prolonged exposure to heat can cause the containers to rupture violently. Option D: Prolonged exposure to intense heat may cause the containers to rupture violently. " B 1146 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C Question about this molecule: How is the stability of this molecule Option A: Prolonged exposure of containers to heat may result in their violent rupturing and rocketing due to decomposition. Option B: Prolonged exposure to intense heat may cause the containers to rupture violently. Option C: Under prolonged exposure to fire or heat, the containers may explode violently. Option D: Prolonged exposure to heat can cause the containers to rupture violently. " D 280 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)=O Question about this molecule: What is the right information about this molecule's storage? Option A: It is typically stored with a stabilizer in a weakly acidic solution. Option B: It is stored and shipped as a mixture with water and alcohol. Option C: It should be stored in a dry place at ambient temperature. Option D: It should be stored in cylinders filled to a high pressure. " D 11443 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)N=C=O)N=C=O Question about this molecule: What is the right information about this molecule's storage? Option A: It should be stored under refrigeration, away from light and moisture in a tightly closed container under an inert atmosphere. Option B: It is usually stored frozen (below 32 °F) in polyethylene bottles that are tightly closed and contained in a metal can. Option C: It should be stored in a cool, ventilated place, away from acute fire hazards and easily oxidized materials. Option D: It is often frozen in a mixture of 10% DMSO and 90% fetal calf serum. " A 6954 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1[N+](=O)[O-])O)[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: What is the right information about this molecule's storage? Option A: It should be stored under refrigeration, away from light and moisture in a tightly closed container under an inert atmosphere. Option B: It should be stored in a cool, ventilated place, away from acute fire hazards and easily oxidized materials. Option C: It is usually stored frozen (below 32 °F) in polyethylene bottles that are tightly closed and contained in a metal can. Option D: It is often frozen in a mixture of 10% DMSO and 90% fetal calf serum. " B 6658 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=C)C(=O)OC Question about this molecule: What is the right information about this molecule's storage? Option A: It should be stored in cylinders filled to a high pressure. Option B: Containers must be heavily insulated or shipped under refrigeration. Option C: It is usually stored as a liquid. Option D: It should be shipped under refrigeration. " B 6338 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCl Question about this molecule: What is the right information about this molecule's storage? Option A: It should be shipped under refrigeration. Option B: It should be stored in cylinders filled to a high pressure. Option C: It is usually stored as a liquid. Option D: Containers must be heavily insulated or shipped under refrigeration. " C 7434 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C=C1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: What is the right information about this molecule's storage? Option A: It should be stored in a cool, ventilated place, away from acute fire hazards and easily oxidized materials. Option B: It is usually stored frozen (below 32 °F) in polyethylene bottles that are tightly closed and contained in a metal can. Option C: It is often frozen in a mixture of 10% DMSO and 90% fetal calf serum. Option D: It should be stored under refrigeration, away from light and moisture in a tightly closed container under an inert atmosphere. " A 948 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N-]=[N+]=O Question about this molecule: What is the right information about this molecule's storage? Option A: It is usually stored as a liquid. Option B: Containers must be heavily insulated or shipped under refrigeration. Option C: It should be stored in cylinders filled to a high pressure. Option D: It should be shipped under refrigeration. " D 586 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(CC(=O)O)C(=N)N Question about this molecule: What is the right information about this molecule's storage? Option A: 95% of it is stored in the skeletal muscles, with the rest in the brain, heart, testes. Option B: It is often frozen in a mixture of 10% DMSO and 90% fetal calf serum. Option C: It should be stored in a cool, ventilated place, away from acute fire hazards and easily oxidized materials. Option D: It is usually stored frozen (below 32 °F) in polyethylene bottles that are tightly closed and contained in a metal can. " A 6518 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(CO[N+](=O)[O-])(CO[N+](=O)[O-])CO[N+](=O)[O-])O[N+](=O)[O-] Question about this molecule: What is the right information about this molecule's storage? Option A: It is typically stored with a stabilizer in a weakly acidic solution. Option B: It should be stored in a dry place at ambient temperature. Option C: It is stored and shipped as a mixture with water and alcohol. Option D: It should be stored in cylinders filled to a high pressure. " C 784 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OO Question about this molecule: What is the right information about this molecule's storage? Option A: It should be stored in cylinders filled to a high pressure. Option B: It is typically stored with a stabilizer in a weakly acidic solution. Option C: It is stored and shipped as a mixture with water and alcohol. Option D: It should be stored in a dry place at ambient temperature. " B 135436526 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C(=N)N[N+](=O)[O-])N=O Question about this molecule: What is the right information about this molecule's storage? Option A: It is usually stored frozen (below 32 °F) in polyethylene bottles that are tightly closed and contained in a metal can. Option B: It is often frozen in a mixture of 10% DMSO and 90% fetal calf serum. Option C: It should be stored under refrigeration, away from light and moisture in a tightly closed container under an inert atmosphere. Option D: It should be stored in a cool, ventilated place, away from acute fire hazards and easily oxidized materials. " A 679 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CS(=O)C Question about this molecule: What is the right information about this molecule's storage? Option A: It is usually stored frozen (below 32 °F) in polyethylene bottles that are tightly closed and contained in a metal can. Option B: It is often frozen in a mixture of 10% DMSO and 90% fetal calf serum. Option C: It should be stored in a cool, ventilated place, away from acute fire hazards and easily oxidized materials. Option D: It should be stored under refrigeration, away from light and moisture in a tightly closed container under an inert atmosphere. " B 7839 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CBr)Br Question about this molecule: What is the right information about this molecule's storage? Option A: It is stored and shipped as a mixture with water and alcohol. Option B: It should be stored in cylinders filled to a high pressure. Option C: It is typically stored with a stabilizer in a weakly acidic solution. Option D: It should be stored in a dry place at ambient temperature. " D 24085 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: Cl[Hg]Cl Question about this molecule: What is the right information about this molecule's sublimation? Option A: It sublimes easily. Option B: It sublimes when gently heated. Option C: It can be sublimed unchanged. Option D: It sublimes in a vacuum. " C 5147 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)C(=O)N)O Question about this molecule: What is the right information about this molecule's sublimation? Option A: It begins to sublime below the melting point. Option B: Sublimation begins at the melting point. Option C: It sublimes easily. Option D: It sublimes when gently heated. " B 7955 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=NC(=NC(=N1)N)N)N Question about this molecule: What is the right information about this molecule's sublimation? Option A: It sublimes when gently heated. Option B: It sublimes easily. Option C: It sublimes in a vacuum. Option D: It sublimes easily under a vacuum. " A 1639 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NNC(=N1)N Question about this molecule: What is the right information about this molecule's sublimation? Option A: It sublimes easily. Option B: It sublimes undecomposed at reduced pressure. Option C: It sublimes when gently heated. Option D: It sublimes in a vacuum. " B 5641 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)N Question about this molecule: What is the right information about this molecule's sublimation? Option A: It sublimes in a vacuum at about 505 °F with some decomposition. Option B: It sublimes slowly at 750 mmHg when heated to the melting point. Option C: It sublimes readily at 217 °F and 54 mmHg. Option D: It sublimes without decomposition at 410 °F. " C 30318 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=[Os](=O)(=O)=O Question about this molecule: What is the right information about this molecule's sublimation? Option A: It sublimes in a vacuum. Option B: It sublimes easily. Option C: It sublimes when gently heated. Option D: It begins to sublime below the melting point. " D 5192 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCCCC(=O)O)CCCC(=O)O Question about this molecule: What is the right information about this molecule's sublimation? Option A: It sublimes without decomposition at 410 °F. Option B: It sublimes in a vacuum at about 505 °F with some decomposition. Option C: It sublimes slowly at 750 mmHg when heated to the melting point. Option D: It sublimes readily at 217 °F and 54 mmHg. " C 867 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)O)C(=O)O Question about this molecule: What is the right information about this molecule's sublimation? Option A: It sublimes easily under a vacuum. Option B: It sublimes in a vacuum. Option C: It sublimes when gently heated. Option D: It sublimes easily. " B 7862 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[Hg]Cl Question about this molecule: What is the right information about this molecule's sublimation? Option A: It sublimes easily. Option B: It sublimes easily under a vacuum. Option C: It sublimes when gently heated. Option D: It sublimes in a vacuum. " A 6853 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C2=CC=CC=C2C3=CC=CC=C31 Question about this molecule: What is the right information about this molecule's sublimation? Option A: It sublimes in a vacuum. Option B: It sublimes easily. Option C: It sublimes when gently heated. Option D: It sublimes easily under a vacuum. " D 2537 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C2CCC1(C(=O)C2)C)C Question about this molecule: What is the right information about this molecule's sublimation? Option A: It sublimes appreciably at room temperature and pressure; 14% sublimes within 60 minutes at 176 °F and 12 mmHg. Option B: It sublimes in a vacuum at about 505 °F with some decomposition. Option C: It sublimes readily at 217 °F and 54 mmHg. Option D: It sublimes slowly at 750 mmHg when heated to the melting point. " A 5280343 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a lightly bitter taste. Option B: It tastes very bitter. Option C: It has a very bitter taste. Option D: It has a bitter taste. " B 10187 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC2=CC3=C(C(=CC=C3)O)C(=C2C(=C1)O)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a spicy taste. Option B: It has a distinct taste. Option C: It has a sweet taste. Option D: It is tasteless. " D 5816 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC[C@@H](C1=CC(=C(C=C1)O)O)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a more intense vanilla odor and taste than vanillin. Option B: It has a slightly alkaline (bitter) taste. Option C: It has a slightly bitter, numbing taste. Option D: It has a slightly alkaline and salty taste. " C 8467 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC1=C(C=CC(=C1)C=O)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a bitter taste and slight odor. Option B: It has a slight odor and taste. Option C: It has a bitter taste and leaves a sensation of warmth on the tongue. Option D: It has a more intense vanilla odor and taste than vanillin. " D 227 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)C(=O)O)N Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a sweetish taste. Option B: It has a bitter taste. Option C: It has a sweet taste. Option D: It has a lightly bitter taste. " A 5147 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)C(=O)N)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slight odor and taste. Option B: It has a bitter taste and leaves a sensation of warmth on the tongue. Option C: It has a bitter taste and slight odor. Option D: It has a slight sweet taste. " B 516892 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(O)[O-].[Na+] Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slightly bitter, numbing taste. Option B: It has a more intense vanilla odor and taste than vanillin. Option C: It has a slightly alkaline and salty taste. Option D: It has a slightly alkaline (bitter) taste. " D 379 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCC(=O)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slightly unpleasant rancid taste. Option B: It has a slightly bitter burning taste. Option C: It has a slightly bitter taste. Option D: It has a slightly sweet taste. " A 24463 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O.O.O.O.O.[O-]S(=O)(=O)[O-].[Cu+2] Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a very bitter taste. Option B: It has a nauseating metallic taste. Option C: It has a lightly bitter taste. Option D: It has a bitter taste. " B 22420 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CNP(=O)(OC1)N(CCCl)CCCl.O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slightly bitter taste. Option B: It has a slightly bitter burning taste. Option C: It has a slightly acid taste. Option D: It has a slightly sweet taste. " A 3767 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CN=CC=C1C(=O)NN Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slightly sweet taste. Option B: It has a slightly bitter burning taste. Option C: The taste is slightly sweet at first and then bitter. Option D: It has a slightly bitter taste. " C 938 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CN=C1)C(=O)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a feebly acid taste. Option B: It has a slightly acid taste. Option C: It has a slightly sweet taste. Option D: It has a slightly bitter taste. " A 8905 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CNCCN1.C(CCC(=O)O)CC(=O)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slightly sweet taste. Option B: It has a slightly acid taste. Option C: It has a slightly bitter taste. Option D: It has a slightly bitter burning taste. " B 5429 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C=NC2=C1C(=O)NC(=O)N2C Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a bitter taste. Option B: It has a slightly bitter taste. Option C: It has a very bitter taste. Option D: It has a lightly bitter taste. " A 38853 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)O)N Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It is tasteless. Option B: It is almost tasteless. Option C: It has a spicy taste. Option D: It has a distinct taste. " B 6575 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=C(Cl)Cl)Cl Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a lightly bitter taste. Option B: It has a sweet taste. Option C: It has a sweet, burning taste. Option D: It has a sweetish taste. " C 6212 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)(Cl)Cl Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slightly acid taste. Option B: It has a slightly bitter taste. Option C: It has a slightly bitter burning taste. Option D: It has a slightly sweet taste. " D 2164 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC1(C(=O)NC(=O)NC1=O)CCC(C)C Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slightly bitter taste. Option B: It has a slightly acid taste. Option C: It has a slightly sweet taste. Option D: It has a slightly bitter burning taste. " A 6224 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Na+].[Na+].[Na+] Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a sweet taste. Option B: It has a distinct taste. Option C: It has a sour taste. Option D: It has a spicy taste. " C 2907 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CNP(=O)(OC1)N(CCCl)CCCl Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slightly bitter burning taste. Option B: It has a slightly bitter taste. Option C: It has a slightly sweet taste. Option D: It has a slightly acid taste. " B 7175 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCOC(=O)C1=CC=C(C=C1)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It is tasteless. Option B: It has a sweet taste. Option C: It has a spicy taste. Option D: It has a distinct taste. " A 5743 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slightly acid taste. Option B: It has a slightly bitter taste. Option C: It has a slightly sweet taste. Option D: It has a slightly bitter burning taste. " B 16666 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1CC[C@H]([C@@H](C1)O)C(C)C Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a spicy taste. Option B: It has a distinct taste. Option C: It has a sweet taste. Option D: It has a peppermint taste. " D 853433 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C=C/C1=CC(=C(C=C1)O)OC Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a bitter taste. Option B: It has a distinct taste. Option C: It has a sweet taste. Option D: It has a spicy taste. " D 6014 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C.Cl Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a very bitter taste. Option B: It has a slightly bitter taste. Option C: It has a bitter taste. Option D: It has a lightly bitter taste. " C 4133 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)C1=CC=CC=C1O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a taste of wintergreen. Option B: It has a spicy taste. Option C: It has a distinct taste. Option D: It has a sweet taste. " A 11 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCl)Cl Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a sweet taste. Option B: It has a spicy taste. Option C: It has a distinct taste. Option D: It has a bitter taste. " A 311 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)O)C(CC(=O)O)(C(=O)O)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a feebly acid taste. Option B: It has a slightly acid taste. Option C: It has an acid taste. Option D: It has a slightly sweet taste. " C 1088 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNCC(=O)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a sweet taste. Option B: It has a bitter taste. Option C: It has a distinct taste. Option D: It has a spicy taste. " A 5641 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)N Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a sharp saline taste. Option B: It has a cooling saline taste. Option C: It has a strong saline taste. Option D: It has a bitter and saline taste. " B 2244 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)OC1=CC=CC=C1C(=O)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slightly sweet taste. Option B: It has a slightly acid taste. Option C: It has a slightly bitter taste. Option D: It has a slightly bitter burning taste. " C 5336 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slightly bitter burning taste. Option B: It has a slightly sweet taste. Option C: It has a slightly acid taste. Option D: It has a slightly bitter taste. " D 3634 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCNC1=C2C(=C(C=C1)CO)SC3=CC=CC=C3C2=O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a very bitter taste. Option B: It has a slightly bitter taste. Option C: It has a lightly bitter taste. Option D: It has a bitter taste. " D 8456 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)C1=C(C=CC(=C1)OC)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slightly acid taste. Option B: It has a slightly bitter burning taste. Option C: It has a slightly bitter taste. Option D: It has a slightly sweet taste. " B 3117 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)C(=S)SSC(=S)N(CC)CC Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slight odor and taste. Option B: It has a more intense vanilla odor and taste than vanillin. Option C: It has a bitter taste and slight odor. Option D: It has an unpleasant taste with metallic or garlic aftertaste. " D 948 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N-]=[N+]=O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a spicy taste. Option B: It has a sweet taste. Option C: It has a distinct taste. Option D: It has a bitter taste. " B 323 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC(=O)O2 Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slight odor and taste. Option B: It has a bitter taste and slight odor. Option C: It has a pleasant fragrant vanilla odor and a bitter aromatic burning taste. Option D: It has a bitter taste and leaves a sensation of warmth on the tongue. " C 54670067 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slightly sweet taste. Option B: It has a slightly bitter taste. Option C: It has a slightly acid taste. Option D: It has a pleasant sharp acidic taste. " D 3118 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)SCCSCC Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slight odor and taste. Option B: It has an unpleasant taste with metallic or garlic aftertaste. Option C: It has a more intense vanilla odor and taste than vanillin. Option D: It has an unidentifiable characteristic taste. " D 702 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCO Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a more intense vanilla odor and taste than vanillin. Option B: It has a characteristic vinous odor and pungent taste. Option C: It has a bitter taste and slight odor. Option D: It has a slight odor and taste. " B 4781 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3 Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slightly bitter aftertaste. Option B: It has a slightly sweet taste. Option C: It has a slightly bitter taste. Option D: It has a slightly bitter burning taste. " A 4173 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NC=C(N1CCO)[N+](=O)[O-] Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a strong saline taste. Option B: It has a cooling saline taste. Option C: It has a sharp saline taste. Option D: It has a bitter and saline taste. " D 977 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a spicy taste. Option B: It has a distinct taste. Option C: It is odorless and tasteless. Option D: It is tasteless. " C 637563 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C=C/C1=CC=C(C=C1)OC Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a spicy taste. Option B: It has a distinct taste. Option C: It has a bitter taste. Option D: It has a sweet taste. " D 4873 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Cl-].[K+] Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a strong saline taste. Option B: It has a bitter and saline taste. Option C: It has a cooling saline taste. Option D: It has a sharp saline taste. " A 784 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: OO Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a very bitter taste. Option B: It has a bitter taste. Option C: It has a slightly bitter taste. Option D: It has a lightly bitter taste. " B 4911 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slightly acid taste. Option B: It has a slightly sweet taste. Option C: It has a slightly bitter burning taste. Option D: It has a slightly bitter taste. " D 11850 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@H]([C@@H]([C@@H]([C@H](CO)O)O)O)O)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slight sweet taste. Option B: It has a slightly bitter taste. Option C: It has a slightly sweet taste. Option D: It has a slightly bitter burning taste. " A 3016 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3 Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a bitter taste and slight odor. Option B: It is tasteless at first with a bitter aftertaste. Option C: It is almost tasteless at first and has a slightly bitter aftertaste. Option D: It has a slightly bitter aftertaste. " B 996 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a distinct taste. Option B: It has a spicy taste. Option C: It is tasteless. Option D: It has a sweet taste. " C 3657 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(N)NO Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a spicy taste. Option B: It has a sweet taste. Option C: It is tasteless. Option D: It has a distinct taste. " C 7410 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C1=CC=CC=C1 Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a sweetish taste. Option B: It has a spicy pungent taste. Option C: It has a sweet taste. Option D: It has a sweet pungent taste. " D 522689 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [F-].[K+] Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a cooling saline taste. Option B: It has a bitter and saline taste. Option C: It has a sharp saline taste. Option D: It has a strong saline taste. " C 3314 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C=CC(=C1)CC=C)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a sweet pungent taste. Option B: It has a spicy pungent taste. Option C: It has a sweet taste. Option D: It has a sweetish taste. " B 1030 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CO)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a sweet taste. Option B: It has a distinct taste. Option C: It is tasteless. Option D: It has a spicy taste. " C 180 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a sweet taste. Option B: It has a bitter taste. Option C: It has a spicy taste. Option D: It has a distinct taste. " D 13344 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[K+].[K+].[K+] Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It is tasteless with a saline taste. Option B: It has a cooling saline taste. Option C: It has a bitter and saline taste. Option D: It has a strong saline taste. " A 935 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Ni] Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a spicy taste. Option B: It is tasteless. Option C: It has a distinct taste. Option D: It has a sweet taste. " B 8691 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)N=NC2=C(N=C(C=C2)N)N.Cl Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slightly acid taste. Option B: It has a slightly bitter taste. Option C: It has a slightly sweet taste. Option D: It has a slightly bitter burning taste. " B 5327 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=NC(=N1)NS(=O)(=O)C2=CC=C(C=C2)N)C Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slightly bitter burning taste. Option B: It has a slightly bitter taste. Option C: It has a slightly acid taste. Option D: It has a slightly sweet taste. " B 6781 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C1=CC=CC=C1C(=O)OCC Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slight odor and taste. Option B: It has a bitter taste and slight odor. Option C: It has a bitter, disagreeable taste. Option D: It has a bitter and saline taste. " C 23976 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Cr] Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has no smell or taste. Option B: It has no odor or taste. Option C: It has neither odor nor taste. Option D: It has no taste. " D 1110 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(=O)O)C(=O)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a bitter taste and slight odor. Option B: It has a bitter taste and leaves a sensation of warmth on the tongue. Option C: It has a more intense vanilla odor and taste than vanillin. Option D: It has a combination of saltiness, bitterness, and acidity taste. " D 264 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(=O)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has mostly pleasant aromas or tastes. Option B: It has no smell or taste. Option C: It has no odor or taste. Option D: It has neither odor nor taste. " A 7543 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1CC2=CC(=C(C=C2)N)Cl)Cl)N Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has neither odor nor taste. Option B: It has no taste. Option C: It has no smell or taste. Option D: It has no odor or taste. " C 679 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CS(=O)C Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a distinctive property of penetrating the skin very readily, allowing the handler to taste it. Option B: It has a bitter taste and leaves a sensation of warmth on the tongue. Option C: It has a more intense vanilla odor and taste than vanillin. Option D: It has a slightly acidic and astringent taste with a faint odor. " A 8400 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(C(=O)C2=CC=CC=C2)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slightly sweet taste. Option B: It has a slightly bitter taste. Option C: It has a slightly acid taste. Option D: It has a slightly acrid taste. " D 174 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CO)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a sweet taste. Option B: It has a distinct taste. Option C: It has a spicy taste. Option D: It has a bitter taste. " A 21013 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=C(C(=C1Cl)Cl)Cl)Cl)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a bitter taste and slight odor. Option B: It has a slight odor and taste. Option C: It has a strong medicinal taste and odor. Option D: It has a slight sweet taste. " C 643460 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C=C/C=C/C(=O)O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slightly bitter, numbing taste. Option B: It has a slightly acidic and astringent taste with a faint odor. Option C: It has a bitter taste and slight odor. Option D: It has a slight odor and taste. " B 460 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC=CC=C1O Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a burning aromatic taste. Option B: It has a bitter taste. Option C: It has a burned taste. Option D: It has a sweet taste. " C 5284429 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O.O.O.O.O.O.[O-]S(=O)(=O)[O-].[Ni+2] Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a lightly bitter taste. Option B: It has a sweet taste. Option C: It has a bitter taste. Option D: It has a sweet astringent taste. " D 516893 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(O)[O-].[K+] Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slightly alkaline (bitter) taste. Option B: It has a slightly bitter, numbing taste. Option C: It has a slightly alkaline and salty taste. Option D: It has a more intense vanilla odor and taste than vanillin. " C 2955 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)N Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slightly sweet taste. Option B: It has a slightly acid taste. Option C: It has a slightly bitter burning taste. Option D: It has a slightly bitter taste. " D 4754 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC1=CC=C(C=C1)NC(=O)C Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a very bitter taste. Option B: It has a bitter taste. Option C: It has a slightly bitter taste. Option D: It has a lightly bitter taste. " D 6115 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)N Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a sweet taste. Option B: It has a burning aromatic taste. Option C: It has a lightly bitter taste. Option D: It has a sweet, burning taste. " B 6140 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C[C@@H](C(=O)O)N Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a slightly bitter burning taste. Option B: It has a slightly acid taste. Option C: It has a slightly bitter taste. Option D: It has a slightly sweet taste. " C 281 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C-]#[O+] Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a distinct taste. Option B: It has a spicy taste. Option C: It is tasteless. Option D: It is odorless and tasteless. " D 4485 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a distinct taste. Option B: It has a spicy taste. Option C: It has a sweet taste. Option D: It is tasteless. " D 6305 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)O)N Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: Flat taste Option B: It has a sweet taste. Option C: Bitter taste Option D: It has a bad taste. " A 2537 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C2CCC1(C(=O)C2)C)C Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: It has a very bitter taste. Option B: It has a bitter taste. Option C: Slightly bitter and cooling taste Option D: It has a lightly bitter taste. " C 4114 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2 Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: Flat taste Option B: Bitter taste followed by tingling sensation Option C: Bitter taste Option D: Slightly bitter and cooling taste " B 5282443 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)/C(=C\\CN2CCCC2)/C3=CC=CC=N3 Question about this molecule: Which kind of taste does this molecule have/exhibit? Option A: Flat taste Option B: It has a sweet taste. Option C: It has a bad taste. Option D: Bitter taste " D 134780 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)N Question about this molecule: What is the right information about this molecule's therapeutic effects? Option A: It has the propensity to completely or partially reverse the abnormal metabolism of damaged brain cells after injury. Option B: It has a variety of therapeutic applications, including pupil dilation and the treatment of anticholinergic poisoning and symptomatic bradycardia in the absence of reversible causes. Option C: It is an immunomodulatory antineoplastic agent. Option D: It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. " C 5732 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)C2=C(N3C=C(C=CC3=N2)C)CC(=O)N(C)C Question about this molecule: What is the right information about this molecule's therapeutic effects? Option A: It has a variety of therapeutic applications, including pupil dilation and the treatment of anticholinergic poisoning and symptomatic bradycardia in the absence of reversible causes. Option B: It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. Option C: It exerts its therapeutic effect by inhibiting autophosphorylation of ALK, ALK-mediated phosphorylation of the downstream signaling protein STAT3, and proliferation of ALK-dependent cancer cells. Option D: It has the propensity to completely or partially reverse the abnormal metabolism of damaged brain cells after injury. " D 64689 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)O)O)O)O Question about this molecule: What is the right information about this molecule's therapeutic effects? Option A: It has the propensity to completely or partially reverse the abnormal metabolism of damaged brain cells after injury. Option B: It is used therapeutically in fluid and nutrient replacement. Option C: Approximately one month of therapy is required before a decrease in fasting blood glucose is seen. Option D: It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. " B 54726191 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1CCO[C@@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O Question about this molecule: How is the tolerability of this molecule Option A: The excellent tolerability is a major factor in the wide use of the drug. Option B: It has an excellent tolerability and minimal toxicity. Option C: Both cream and suppository forms have demonstrated high levels of safety, efficacy, and tolerability. Option D: It is generally well tolerated and a useful alternative to non-selective β-blocker drugs. " B 5732 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)C2=C(N3C=C(C=CC3=N2)C)CC(=O)N(C)C Question about this molecule: How is the tolerability of this molecule Option A: It has an excellent tolerability and minimal toxicity. Option B: It seems to be well tolerated, but patients with renal impairment may develop neurotoxicity. Option C: The excellent tolerability is a major factor in the wide use of the drug. Option D: Its tolerability profile is favorable. " D 2581 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C1=CC2=C(C=C1)C3=C(N2)C=CC(=C3)Cl)C(=O)O Question about this molecule: How is the tolerability of this molecule Option A: It was generally well tolerated. Option B: It is well tolerated in most patients. Option C: It is generally well tolerated. Option D: It appears to be well tolerated. " A 3672 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CC1=CC=C(C=C1)C(C)C(=O)O Question about this molecule: How is the tolerability of this molecule Option A: It has been better tolerated than tri- or heterocyclic antidepressants. Option B: It seems to be well tolerated, but patients with renal impairment may develop neurotoxicity. Option C: It has a side-effect profile superior to that of other antihypertensive drugs. Option D: It is generally well tolerated but can rarely cause clinically apparent and serious acute liver injury. " D 5206 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(OC(C(F)(F)F)C(F)(F)F)F Question about this molecule: How is the tolerability of this molecule Option A: The hemodynamic and respiratory depressive effects are well tolerated. Option B: It is generally well tolerated but can rarely cause clinically apparent and serious acute liver injury. Option C: It has been better tolerated than tri- or heterocyclic antidepressants. Option D: It seems to be well tolerated, but patients with renal impairment may develop neurotoxicity. " A 43815 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4 Question about this molecule: How is the tolerability of this molecule Option A: It appears to be well tolerated. Option B: It is well tolerated in most patients. Option C: It is generally well tolerated. Option D: It was generally well tolerated. " B 1983 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)NC1=CC=C(C=C1)O Question about this molecule: How is the tolerability of this molecule Option A: It is generally well tolerated and a useful alternative to non-selective β-blocker drugs. Option B: Both cream and suppository forms have demonstrated high levels of safety, efficacy, and tolerability. Option C: It has an excellent tolerability and minimal toxicity. Option D: The excellent tolerability is a major factor in the wide use of the drug. " D 2405 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O Question about this molecule: How is the tolerability of this molecule Option A: Both cream and suppository forms have demonstrated high levels of safety, efficacy, and tolerability. Option B: It is generally well tolerated and a useful alternative to non-selective β-blocker drugs. Option C: The establishment of tolerability is required prior to dosing in treatment-naïve patients. Option D: It has a side-effect profile superior to that of other antihypertensive drugs. " B 446512 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1CC[C@]2(CCCCO2)O[C@@H]1[C@@H](C)C[C@@H]([C@@H]3C(=C)[C@H]([C@H]4[C@H](O3)CC[C@]5(O4)CC[C@@H](O5)/C=C/[C@@H](C)[C@@H]6CC(=C[C@@]7(O6)[C@@H](CC[C@H](O7)C[C@](C)(C(=O)O)O)O)C)O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of clinically apparent, idiosyncratic drug induced liver disease. Option B: It is one of the primary causes of diarrhetic shellfish poisoning (DSP). Option C: It has been linked to rare cases of idiosyncratic, clinically apparent liver injury. Option D: It has been linked to rare instances of clinically apparent, idiosyncratic liver injury. " B 35970 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C1CSSSC1 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic to birds, most aquatic organisms, and earthworms. Option B: It is moderately toxic to birds, most aquatic organisms, honeybees and earthworms. Option C: It is moderately toxic to humans, mammals, birds and most aquatic organisms. Option D: It is toxic to bees, fish, and other aquatic organisms. " D 3736 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(CC(CO)O)C(=O)C1=C(C(=C(C(=C1I)C(=O)NCC(CO)O)I)NC(=O)COC)I Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is a nephrotoxic agent. Option B: It is a hepatotoxic agent and a nephrotoxin. Option C: It is both carcinogenic and nephrotoxic. Option D: It is a nephrotoxin. " A 6505803 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\\C=C(\\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)/C)OC)OC(=O)N)\\C)C)O)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can be toxic to other cockroaches in the same nesting site. Option B: It is less toxic than phenytoin. Option C: It is much less toxic than chromium (VI). Option D: It is a less toxic analogue than geldanamycin. " D 66977 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCCCCN=C(N)N)CCCCN=C(N)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It acts as a fast-acting neurotoxin in insects. Option B: It is a neurotoxin. Option C: It is a nephrotoxin. Option D: It is a hepatotoxic agent and a nephrotoxin. " D 3634 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCNC1=C2C(=C(C=C1)CO)SC3=CC=CC=C3C2=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic and has concern about possible carcinogenicity. Option B: It exhibits mild toxicity and is carcinogenic. Option C: It exhibits toxicity and carcinogenicity in animals. Option D: It is toxic and may be carcinogenic. " A 170014 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[C@@](CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits lower calcium antagonistic activity and toxicity than racemic verapamil. Option B: Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity. Option C: It exhibits lower calcium antagonistic activity and toxicity than racemic verapamil hydrochloride. Option D: It has low inhalation hazard and no apparent skin manifestations or other toxicity in humans. " C 398 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[N+](=O)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is both carcinogenic and nephrotoxic. Option B: It is a hepatotoxic agent and a carcinogenic agent. Option C: It is a carcinogenic agent, a mutagen, and a teratogenic agent. Option D: It is a hepatotoxic agent and a nephrotoxin. " B 65808 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[C@@](CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits lower calcium antagonistic activity and toxicity than racemic verapamil. Option B: It exhibits lower calcium antagonistic activity and toxicity than racemic verapamil hydrochloride. Option C: It has lower toxicity against vertebrates than most conventional insecticides. Option D: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. " A 177859 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCN(C)CC[C@H]1[C@H]2COC(=O)[C@@H]2[C@@H](C3=CC4=C(C=C13)OCO4)C5=CC(=C(C(=C5)OC)O)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is linked to rare cases of clinically apparent drug-induced liver disease. Option B: It is significantly more toxic to non-small cell lung cancer cells. Option C: It has been linked to rare instances of clinically apparent acute drug induced liver injury. Option D: It has been linked to rare cases of clinically apparent drug induced liver disease. " B 1322 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNNC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is a powerful DNA alkylating agent and carcinogen. Option B: It exhibits mild toxicity and is carcinogenic. Option C: It is a potential carcinogen. Option D: It is genotoxic and may be a carcinogen. " A 11527333 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](C1=C(C=C(C=C1)Cl)Cl)NC(=O)C(C#N)C(C)(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is highly toxic to mammals and insects. Option B: It is highly toxic to aquatic life, particularly fish. Option C: It is toxic to fish. Option D: It is moderately toxic to fish. " D 2724385 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5C[C@H]([C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)O)C)C)C)O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is extremely toxic from acute and chronic exposures. Option B: It is toxic in large doses. Option C: The margin between toxic and therapeutic doses is small. Option D: It exhibits toxic effects with excess exposure. " C 4756 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)N=NC2=C(N=C(C=C2)N)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with a risk for severe toxicity and overdose, especially in children. Option B: Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity. Option C: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent acute liver injury with jaundice. Option D: It can cause drug overdose and toxicity from accidental ingestion due to its profound sedation effects. " B 43233 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1COC(O1)(CN2C=NC=N2)C3=C(C=C(C=C3)Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is moderately toxic to humans, mammals, birds and most aquatic organisms. Option B: It is moderately toxic to mammals, birds, fish, and aquatic invertebrates. Option C: It is toxic to birds, most aquatic organisms, and earthworms. Option D: It is moderately toxic to birds, most aquatic organisms, honeybees and earthworms. " B 6347 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=N)=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is a poisonous inorganic compound. Option B: It is extremely poisonous. Option C: It is poisonous. Option D: It is extremely toxic to birds. " A 8691 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)N=NC2=C(N=C(C=C2)N)N.Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause drug overdose and toxicity from accidental ingestion due to its profound sedation effects. Option B: It has low to moderate acute toxicity, with kidney and liver effects as the main hazard concerns. Option C: It has low inhalation hazard and no apparent skin manifestations or other toxicity in humans. Option D: Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity. " D 446156 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C1=C(C(=C(C(=N1)C(C)C)COC)C2=CC=C(C=C2)F)/C=C/[C@H](C[C@H](CC(=O)O)O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits acute and chronic liver toxicity. Option B: It exhibits severe muscle toxicity. Option C: It exhibits acute liver toxicity. Option D: It exhibits rare acute liver toxicity. " B 5852 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)([C@H](C(=O)O)N)S Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is moderately toxic to fish. Option B: It is toxic to fish. Option C: It is extremely toxic to birds. Option D: The L-form is toxic. " D 21729595 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC[C@@H](C=C1)[C@H](C)CCC=C(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has toxic effects in various test animals. Option B: It exhibits toxic effects with excess exposure. Option C: It has toxic and repellent properties. Option D: It can produce toxic materials during combustion. " C 24085 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: Cl[Hg]Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may be slightly toxic by ingestion. Option B: It is slightly toxic. Option C: It is highly toxic. Option D: It is extremely toxic to birds. " C 177 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is both carcinogenic and nephrotoxic. Option B: Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity. Option C: It is a carcinogenic agent, a mutagen, and a teratogenic agent. Option D: It exhibits toxicity and carcinogenicity in animals. " C 8064 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCO)CO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits severe muscle toxicity. Option B: It exhibits potential neurotoxicity. Option C: It acts as a fast-acting neurotoxin in insects. Option D: It is a neurotoxin. " D 132472361 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)/C(=N/P(=O)(OCC)F)/C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is a nephrotoxic agent. Option B: It is a neurotoxin. Option C: It is a hepatotoxic agent and a nephrotoxin. Option D: It is a nephrotoxin. " B 241 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=CC=C1 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may cause severe damage to the skin, eyes, respiratory tract, and mucous membranes and cause depression of the central nervous system in humans. Option B: It is a central nervous system toxicant and has been shown to damage the lungs and kidneys in animal testing. Option C: It can cause eye and skin irritation and toxic effects on the liver, kidneys, and central and peripheral nervous systems. Option D: It is a carcinogen that also damages bone marrow and the central nervous system. " D 8058 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is a neurotoxin. Option B: It is a hepatotoxic agent and a nephrotoxin. Option C: It is a nephrotoxin. Option D: It acts as a fast-acting neurotoxin in insects. " A 132472360 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)/C(=N/P(=O)(OC)F)/C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is a nephrotoxin. Option B: It is a hepatotoxic agent and a nephrotoxin. Option C: It is a hepatotoxic agent and a carcinogenic agent. Option D: It is a neurotoxin. " D 23668195 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]Br(=O)=O.[Na+] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is a nephrotoxin. Option B: It is a hepatotoxic agent and a nephrotoxin. Option C: It is a nephrotoxic agent. Option D: It is both carcinogenic and nephrotoxic. " A 27375 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)NC(=O)N(C)C)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is moderately toxic to mammals, birds, fish, and aquatic invertebrates. Option B: It is moderately toxic to birds, most aquatic organisms, honeybees and earthworms. Option C: It is moderately toxic to mammals, birds, earthworms and most aquatic organisms. Option D: It is moderately toxic to humans, mammals, birds and most aquatic organisms. " C 3025 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOC1=NC2=CC=CC=C2C(=C1)C(=O)NCCN(CC)CC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is extremely toxic to birds. Option B: It is slightly toxic. Option C: It is highly toxic. Option D: It may be slightly toxic by ingestion. " C 7862 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[Hg]Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is highly toxic. Option B: It is moderately toxic by ingestion. Option C: It may be slightly toxic by ingestion. Option D: It is slightly toxic. " A 12771 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=O)C(=CC1=O)Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits mild toxicity and is carcinogenic. Option B: It is toxic and may be carcinogenic. Option C: It is highly toxic and carcinogenic. Option D: It is toxic and carcinogenic. " C 8029 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=COC=C1 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is highly toxic and carcinogenic. Option B: It exhibits mild toxicity and is carcinogenic. Option C: It is toxic and may be carcinogenic. Option D: It is mildly toxic and carcinogenic. " C 54675783 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: Long-term therapy with this molecule is associated with the development of fatty liver, steatohepatitis, cirrhosis, and rare instances of clinically apparent acute liver injury. Option B: It has been linked to cases of acute liver injury, including acute cholestatic hepatitis and veno-occlusive disease. Option C: It can lead to acute psychosis, aggressive and violent behaviors, and overdoses can cause status epilepticus, hyperthermia, rhabdomyolysis and subsequent renal, respiratory and hepatic failure. Option D: It can cause both an acute hepatitis-like syndrome and a more insidious chronic hepatitis with autoimmune features. " D 18752 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)NS(=O)(=O)C1=CC=C(C=C1)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low mammalian oral and dermal toxicity. Option B: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. Option C: It has relatively low mammalian oral and dermal toxicity. Option D: It has low mammalian toxicity, but there is some concern regarding its potential for bioaccumulation. " C 7498 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)CBr Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by inhalation and by skin absorption. Option B: It is toxic by inhalation and skin absorption. Option C: It is toxic by inhalation, ingestion, and skin absorption. Option D: It is toxic by ingestion, inhalation, and skin absorption. " A 5280343 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is generally well tolerated and has not been linked to serum enzyme elevations or clinically apparent liver injury. Option B: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option C: It has rarely been implicated in causing serum enzyme elevations and has not been reported to cause clinically apparent liver injury. Option D: It is well tolerated and has not been linked to serum enzyme elevations or episodes of clinically apparent liver injury. " D 5281873 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C(C1C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)/C=C(/C(F)(F)F)\\Cl)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can harm sensitive individuals. Option B: It can harm sensitive individuals but is generally harmless to human beings in the concentrations used in such products. Option C: It is generally harmless to human beings but can harm sensitive individuals. Option D: It is generally harmless but can harm sensitive individuals. " C 135398739 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C[C@@H](O[C@@H]1CO)N2C=NC3=C2N=CNC3=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with an appreciable rate of serum enzyme elevations and is a well established cause of clinically apparent acute liver injury. Option B: It is associated with minor transient serum enzyme elevations and has been linked to rare cases of clinically apparent acute liver injury. Option C: It has been associated with serum enzyme elevations during therapy and with rare instances of clinically apparent acute liver injury. Option D: It can cause mild and transient serum enzyme elevations and is a rare cause of clinically apparent acute liver injury. " A 31116 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[C@@]1(C(=O)N2[C@H](C(=O)N3CCC[C@H]3[C@@]2(O1)O)CC4=CC=CC=C4)NC(=O)[C@H]5CN([C@@H]6CC7=CNC8=CC=CC(=C78)C6=C5)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause manganism, a neurodegenerative disorder that causes dopaminergic neuronal death and parkinsonian-like symptoms. Option B: It can cause ergotism, a disease causing convulsive and gangrenous symptoms. Option C: It can cause neurotoxicity in humans, including numbness, cyanosis, hyperesthesia, and muscle spasms. Option D: It affects the liver, including hepatitis and jaundice, and central nervous system effects, such as depression and irritability. " B 280 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is relatively nontoxic and noncombustible. Option B: It is non-toxic. Option C: It is highly toxic to aquatic life, particularly fish. Option D: It is non-addictive and non-toxic. " A 2268 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=S)(OC)SCN1C(=O)C2=CC=CC=C2N=N1 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by inhalation, skin absorption, or ingestion. Option B: It is toxic by inhalation, skin absorption, and ingestion. Option C: It is toxic by ingestion, inhalation, or skin absorption. Option D: It is toxic by inhalation, skin absorption, and/or ingestion. " D 3035 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C(=C(Cl)Cl)C2=CC=C(C=C2)Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can depress the central nervous system (CNS), irritate the lungs and skin, and affect the kidneys. Option B: It can cause central nervous system (CNS) effects, such as headaches, nausea, and convulsions. Option C: It affects the liver, including hepatitis and jaundice, and central nervous system effects, such as depression and irritability. Option D: It affects the human central nervous system (CNS), with symptoms such as dizziness, headaches, confusion, euphoria, facial numbness, and weakness. " B 10907 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CC(C)(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may cause severe damage to the skin, eyes, respiratory tract, and mucous membranes and cause depression of the central nervous system in humans. Option B: It can cause irritation of the eyes, skin, nose, throat, and lungs, and damage to the brain and nervous system. Option C: It can cause necrosis of the skin and tissue. Option D: It may cause severe inflammation and necrosis of the eyes, mouth, and respiratory tract. " C 6604200 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C(=O)NC(=O)N1/N=C/C2=CC=C(O2)[N+](=O)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to cases of acute liver injury, including acute cholestatic hepatitis and veno-occlusive disease. Option B: It is one of the most common causes of drug induced liver disease and can cause either an acute or a chronic hepatitis-like syndrome. Option C: Long-term therapy with this molecule is associated with the development of fatty liver, steatohepatitis, cirrhosis, and rare instances of clinically apparent acute liver injury. Option D: It can cause minor transient serum enzyme elevations and has been linked to cases of acute liver injury including cholestatic hepatitis and acute veno-occlusive disease. " B 12699 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C(=O)N)N=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause tumors of the brain, spinal cord, nerves, stomach, pancreas, and kidneys. Option B: It may cause severe damage to the skin, eyes, respiratory tract, and mucous membranes and cause depression of the central nervous system in humans. Option C: It can cause irritation of the eyes, skin, nose, throat, and lungs, and damage to the brain and nervous system. Option D: It can cause eye and skin irritation and toxic effects on the liver, kidneys, and central and peripheral nervous systems. " A 2520 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has the potential for serious morbidity and mortality with over dosage. Option B: It has been associated with occasional cases of severe and distinctive acute hepatic failure. Option C: It has been linked to instances of clinically apparent acute liver injury and long-term therapy to nodular regenerative hyperplasia. Option D: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent acute liver injury with jaundice. " A 24085 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: Cl[Hg]Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with frequent serum enzyme elevations but not clinically apparent liver injury with jaundice. Option B: It is a highly toxic compound that volatizes slightly at ordinary temperature and appreciably at 100 degrees C. Option C: It is less potent but less toxic than the molecule produced in the 1950s. Option D: It is generally well tolerated and has not been linked to serum enzyme elevations or clinically apparent liver injury. " B 2719 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is moderately toxic to fish. Option B: It is toxic to fish. Option C: It is toxic to the parasites. Option D: It is extremely toxic to birds. " C 54726191 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1CCO[C@@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low acute toxicity. Option B: It has minimal toxicity. Option C: It has low toxicity to mammals. Option D: It has low toxicity. " B 6328 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CI Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can depress the central nervous system (CNS), irritate the lungs and skin, and affect the kidneys. Option B: It may cause severe damage to the skin, eyes, respiratory tract, and mucous membranes and cause depression of the central nervous system in humans. Option C: It can cause tumors of the brain, spinal cord, nerves, stomach, pancreas, and kidneys. Option D: It can cause eye and skin irritation and toxic effects on the liver, kidneys, and central and peripheral nervous systems. " A 439213 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@@H]1[C@H]([C@@H]([C@H](C(O1)O)N)O)O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of clinically apparent liver injury. Option B: It has been linked to rare instances of clinically apparent acute liver injury. Option C: It has rare occurrences of clinically apparent liver injury. Option D: It has been associated with rare instances of clinically apparent liver injury. " C 1549008 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)C#C/C=C/CN(C)CC1=CC=CC2=CC=CC=C21 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been reported to cause clinically apparent fatal, acute liver injury. Option B: It can cause clinically apparent acute liver injury. Option C: It can cause clinically apparent, acute liver injury. Option D: It can cause severe and sometimes fatal acute liver injury. " D 135410875 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)N[C@@H](CCC(=O)O)C(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has serum enzyme elevations and has been linked to rare instances of clinically apparent liver injury. Option B: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option C: It has been associated with serum enzyme elevations during therapy and with rare instances of clinically apparent acute liver injury. Option D: It has moderate rates of serum enzyme elevations during therapy. " D 10967 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(OCCl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause chronic bronchitis, chronic cough, and impaired respiratory function. Option B: It can cause symptoms of acute inhalation exposure such as dizziness, nausea, vomiting, diarrhea, loss of consciousness, and decreased blood pressure. Option C: Acute and chronic inhalation exposure to it in humans can result in respiratory symptoms, and eye, nose, and throat irritation. Option D: It can cause chronic bronchitis, asthma-like attacks, and upper respiratory tract and eye irritation. " A 4004 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)CC(C(=O)OCC)SP(=S)(OC)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low human toxicity. Option B: It has low acute and chronic toxicity. Option C: It has low acute toxicity. Option D: It has low acute animal toxicity. " A 6569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits toxicity in the form of toxic oxides of nitrogen when exposed to heat or flames. Option B: It exhibits toxicity in the form of toxic oxides of nitrogen. Option C: It produces toxic oxides of nitrogen during combustion. Option D: It can produce toxic materials during combustion. " D 6278 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(Cl)(Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause symptoms of acute inhalation exposure such as dizziness, nausea, vomiting, diarrhea, loss of consciousness, and decreased blood pressure. Option B: Acute inhalation exposure to it may cause irritation of the eyes, cough, wheezing, asthmatic symptoms, pulmonary edema, pneumonia, dizziness, weakness, headache, and chest pains. Option C: It can result in weakness, headache, dizziness, nausea, abdominal pain, myotonia, hypotension, renal and hepatic injury, and delayed neuropathy. Option D: It may cause headaches, dizziness, fatigue, drowsiness, burning substernal pain, nausea, vomiting, cough, labored breathing, chest tightness, pulmonary irritation, pulmonary edema, and tremors in humans. " A 2733 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC2=C(C=C1Cl)NC(=O)O2 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to several cases of clinically apparent drug induced liver disease, some of which have been severe and even fatal. Option B: It has been linked to rare cases of drug-induced liver injury, some of which have been fatal. Option C: It has rare instances of acute liver injury, some of which have been fatal. Option D: It has been linked to numerous cases of acute liver injury, which are frequently severe and can be fatal. " C 245005 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN1C[C@@]2([C@@H](C[C@@H]([C@@]34[C@@H]2[C@H]([C@@H](C31)[C@@]5([C@@H]6[C@H]4C[C@@]([C@@H]6OC(=O)C7=CC=CC=C7)([C@H]([C@@H]5O)OC)O)OC(=O)C)OC)OC)O)COC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has toxic effects in various test animals. Option B: It is toxic by inhalation and ingestion. Option C: It is toxic to target insects through direct applications and by ingestion. Option D: It has caused a variety of tumors in laboratory animals. " A 5790 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)F)CO)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with a high rate of serum enzyme and bilirubin elevations during therapy and frequent biliary damage. Option B: It can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. Option C: It is associated with transient elevations in serum aminotransferase levels during therapy and has been reported to cause clinically apparent acute liver injury and rare instances of death. Option D: It is associated with transient elevations in serum aminotransferase and bilirubin levels and rare instances of clinically apparent acute liver injury. " A 4543 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause mild and transient serum enzyme elevations and has been linked to rare instances of clinically apparent cholestatic liver injury. Option B: It can cause mild and transient serum enzyme elevations and is a rare cause of clinically apparent acute cholestatic liver injury. Option C: It can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute cholestatic liver injury. Option D: It can cause mild and transient serum enzyme elevations and rare cholestatic liver injury. " D 2256 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC1=NC(=NC(=N1)Cl)NC(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low to moderate acute toxicity, with kidney and liver effects as the main hazard concerns. Option B: It has minimal oral absorption and has not been implicated in causing liver test abnormalities or clinically apparent liver injury. Option C: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent acute liver injury with jaundice. Option D: It has low inhalation hazard and no apparent skin manifestations or other toxicity in humans. " D 152946 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C2C(=CC(=C1N3C[C@@H]4CCCN[C@@H]4C3)F)C(=O)C(=CN2C5CC5)C(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is linked to mild ALT elevations during therapy and rare instances of idiosyncratic acute liver injury. Option B: It has been linked to rare instances of idiosyncratic, clinically apparent acute liver injury. Option C: It has been linked to many cases of idiosyncratic acute liver injury that are frequently severe. Option D: It has been linked to rare instances of clinically apparent, idiosyncratic liver injury. " A 47898 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)OC1=CC=CC(=C1)NC(=O)C2=CC=CC=C2C(F)(F)F Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low toxicity and good selectivity. Option B: It has low acute toxicity. Option C: It has low toxicity to mammals. Option D: It has low acute toxicity to mammals. " D 9837243 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC[C@@H]1CC(=O)N(C1)[C@@H](CC)C(=O)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare cases of drug-induced liver injury. Option B: It is suspected of causing drug-induced liver disease. Option C: It is linked to rare instances of clinically apparent acute liver injury. Option D: It has been linked to rare instances of clinically apparent acute liver injury. " B 5371562 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C/C(=C\\C(=O)NC)/OP(=O)(OC)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is extremely toxic to birds. Option B: It is highly toxic to mammals and insects. Option C: It is selectively more toxic to insects than mammals. Option D: It is moderately toxic to fish. " A 5360741 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC2=C1C3=C(C(=CC(=C3)OC)O)C(=O)O2)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity. Option B: It is both carcinogenic and nephrotoxic. Option C: It demonstrates developmental toxicity and has been classified as a Group B2 carcinogen (probable human carcinogen). Option D: It is toxic, genotoxic, mutagenic, and carcinogenic. " D 4539 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCNCC3)F)C(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of acute cholestatic liver injury. Option B: It has been linked to rare instances of clinically apparent acute cholestatic liver injury. Option C: It has been linked to rare instances of acute hepatocellular injury. Option D: It has been linked to acute hepatocellular injury. " D 7840 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCBr Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may emit toxic fumes when heated. Option B: It may emit highly toxic nitrogen oxide fumes when heated to decomposition. Option C: It emits toxic fumes when heated. Option D: It emits toxic oxides of nitrogen fumes when heated to decomposition. " A 3120 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C(=O)NC1=CC(=C(C=C1)Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may be slightly toxic by ingestion, inhalation, and skin absorption. Option B: It can cause illness by inhalation, skin absorption and/or ingestion. Option C: It can cause illness by inhalation, skin absorption, and/or ingestion. Option D: It may cause illness by inhalation, skin absorption, and/or ingestion. " C 11443 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)N=C=O)N=C=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is extremely toxic from acute and chronic exposures. Option B: It is moderately toxic by ingestion. Option C: It is extremely toxic to birds. Option D: It exhibits toxic effects with excess exposure. " A 2796 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)C(C)(C)OC1=CC=C(C=C1)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with mild and transient serum aminotransferase elevations and rare instances of acute liver injury. Option B: It is associated with a moderate rate of serum aminotransferase elevations and rare instances of clinically apparent acute liver injury. Option C: It is associated with a moderate rate of serum aminotransferase elevations during therapy and rare instances of clinically apparent acute liver injury. Option D: It is associated with a low rate of transient serum aminotransferase elevations and with rare instances of clinically apparent acute liver injury. " A 2724354 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C@@H]([C@@H](C(=O)O)S)(C(=O)O)S Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has a low rate of transient serum aminotransferase elevations during therapy. Option B: It is associated with a low rate of transient serum aminotransferase elevations and rare instances of acute liver injury. Option C: It has a low rate of transient serum aminotransferase elevations and has been linked to rare instances of acute liver injury. Option D: It has a low rate of transient serum aminotransferase elevations and rare instances of acute liver injury. " A 23953 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [SiH4] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is poisonous. Option B: It exhibits poisonous toxicity. Option C: It is a poisonous gas with a strong repulsive odor. Option D: It is a poisonous metalloid. " C 5959 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1[C@H]([C@@H](CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been associated with serum enzyme elevations during therapy and with rare instances of clinically apparent acute liver injury. Option B: It has been linked to acute liver injury with jaundice, largely in association with aplastic anemia. Option C: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent acute liver injury with jaundice. Option D: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. " B 115355 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC(=O)C(C(=O)C1)C(=O)C2=C(C=C(C=C2)C(F)(F)F)[N+](=O)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It causes moderate serum aminotransferase elevations. Option B: It is associated with transient and usually mild elevations in serum aminotransferase levels. Option C: It often causes mild to moderate elevations in serum aminotransferase levels. Option D: It has been associated with mild, transient serum aminotransferase elevations. " D 208898 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C)C(=O)C3=CC=C(C=C3)OCCCN(CCCC)CCCC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with minor transient serum enzyme elevations and has been linked to rare cases of clinically apparent acute liver injury. Option B: It is associated with a high rate of serum enzyme elevations and rare instances of clinically apparent acute liver injury. Option C: It is associated with a variable rate of serum enzyme elevations during therapy and rare instances of severe liver injury. Option D: It has been associated with serum enzyme elevations during therapy and with rare instances of clinically apparent acute liver injury. " C 5359464 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Tl] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It emits toxic fumes when heated. Option B: It emits toxic oxides of nitrogen fumes when heated to decomposition. Option C: It may emit highly toxic nitrogen oxide fumes when heated to decomposition. Option D: It emits toxic oxides of nitrogen when heated to decomposition. " A 5364932 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)/C(=N\\OC(=O)NC)/CSC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. Option B: It has relatively low mammalian oral and dermal toxicity. Option C: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. Option D: It has low mammalian oral and dermal toxicity. " D 4055 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=O)C2=CC=CC=C2C1=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may cause severe damage to the skin, eyes, respiratory tract, and mucous membranes and cause depression of the central nervous system in humans. Option B: It can cause cataracts, skin lesions, weight loss, and affect the bone marrow, central nervous system, and cardiovascular system. Option C: Large doses can cause adverse outcomes including hemolytic anemia, neonatal brain or liver damage, or neonatal death. Option D: It can result in weakness, headache, dizziness, nausea, abdominal pain, myotonia, hypotension, renal and hepatic injury, and delayed neuropathy. " C 8119 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCCNCC1 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits toxicity in the form of toxic oxides of nitrogen when exposed to heat or flames. Option B: It exhibits toxicity in the form of toxic oxides of nitrogen. Option C: It emits toxic oxides of nitrogen when heated to decomposition. Option D: It produces toxic oxides of nitrogen during combustion. " B 4929 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NC1=NC(=NC(=N1)SC)NC(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits moderate acute oral toxicity to mammals but has high acute oral toxicity to birds. Option B: It is a slightly to moderately toxic compound which is classified as a member of toxicity class II or III, depending on the formulation. Option C: It has low inhalation hazard and no apparent skin manifestations or other toxicity in humans. Option D: It has low to moderate acute toxicity, with kidney and liver effects as the main hazard concerns. " B 6184 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause severe liver damage and some kidney damage from acute inhalation exposure. Option B: It can cause chronic exposure of uremic toxins, leading to conditions such as renal damage, chronic kidney disease, and cardiovascular disease. Option C: It can lead to renal damage, chronic kidney disease, and cardiovascular disease. Option D: It can cause symptoms of acute inhalation exposure such as dizziness, nausea, vomiting, diarrhea, loss of consciousness, and decreased blood pressure. " B 9554 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(C(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits mild toxicity and is carcinogenic. Option B: It exhibits toxicity and carcinogenicity in animals. Option C: It is toxic and may be carcinogenic. Option D: It is mildly toxic and carcinogenic. " B 27455 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [NH4+].[NH4+].[O-]S(=O)(=O)[O-].[O-]S(=O)(=O)[O-].[Ni+2] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is mildly toxic and carcinogenic. Option B: It is highly toxic and carcinogenic. Option C: It exhibits mild toxicity and is carcinogenic. Option D: It exhibits toxicity and carcinogenicity in animals. " C 4748 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute cholestatic liver injury. Option B: It can cause mild and transient serum enzyme elevations and is a rare cause of clinically apparent acute and chronic cholestatic liver injury. Option C: It has a low rate of mild and transient serum enzyme elevations and rare cases of clinically apparent acute cholestatic liver injury. Option D: It can cause mild and transient serum enzyme elevations and is a rare cause of clinically apparent acute cholestatic liver injury. " B 3025 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOC1=NC2=CC=CC=C2C(=C1)C(=O)NCCN(CC)CC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is one of the most poisonous non-protein substances known, second only to maitotoxin in terms of toxicity in mice. Option B: It is one of the most potent and toxic long-acting local anesthetics, with parenteral use restricted to spinal anesthesia. Option C: It has been linked to rare instances of clinically apparent, idiosyncratic drug induced liver disease. Option D: It has been linked to several cases of clinically apparent drug induced liver disease, some of which have been severe and even fatal. " B 24743 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)NC1=CC(=CC=C1)OC(=O)NC2=CC=CC=C2 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has relatively low mammalian oral and dermal toxicity and broad control spectrum, making it widely used in lawn and garden settings. Option B: It has relatively low mammalian oral and dermal toxicity. Option C: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. Option D: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. " A 51605 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)NCCOC1=CC=C(C=C1)OC2=CC=CC=C2 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. Option B: It has low mammalian toxicity, but there is some concern regarding its potential for bioaccumulation. Option C: It has relatively low mammalian oral and dermal toxicity and broad control spectrum, making it widely used in lawn and garden settings. Option D: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. " C 785 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause inflammation and irritation to the urinary bladder and urethra, and similar changes have recently been described in the biliary tract, resulting in an acute or chronic cholestatic liver injury that can resemble sclerosing cholangitis. Option B: Ingestion of a large amount of this molecule can result in tinnitus, dizziness, headache, nausea, vomiting, dyspnea, erosion of the gastric mucosa, edema of internal organs, cyanosis, convulsions, delirium, and collapse in humans. Option C: It has been associated with rare instances of idiosyncratic acute liver injury; in addition, prolonged high dose therapy can cause the “infusion syndrome” which is marked by bradyarrhythmias, metabolic acidosis, rhabdomyolysis, hyperlipidemia and an enlarged or fatty liver. Option D: It can lead to acute psychosis, aggressive and violent behaviors, and overdoses can cause status epilepticus, hyperthermia, rhabdomyolysis and subsequent renal, respiratory and hepatic failure. " B 2566 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(CC2=C(O1)C(=CC=C2)OC(=O)NC)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It emits toxic oxides of nitrogen when heated to decomposition. Option B: It exhibits toxicity in the form of toxic oxides of nitrogen when exposed to heat or flames. Option C: It produces toxic oxides of nitrogen during combustion. Option D: It exhibits toxicity in the form of toxic oxides of nitrogen. " B 10111 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN=C(N)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is a cause of clinically apparent acute drug induced liver injury and is no longer recommended as a first line antifungal agent. Option B: It is a suspected uraemic toxin that accumulates in renal failure, but it also exhibits anti-inflammatory effects. Option C: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent acute liver injury with jaundice. Option D: It has been linked to instances of clinically apparent acute liver injury and long-term therapy to nodular regenerative hyperplasia. " B 145068 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N]=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is very toxic by inhalation and skin absorption. Option B: It is very toxic by inhalation, skin absorption, and ingestion. Option C: It is very toxic by skin absorption and inhalation. Option D: It is very toxic by ingestion, inhalation, or skin absorption. " A 2733526 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC/C(=C(\\C1=CC=CC=C1)/C2=CC=C(C=C2)OCCN(C)C)/C3=CC=CC=C3 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can lead to acute psychosis, aggressive and violent behaviors, and overdoses can cause status epilepticus, hyperthermia, rhabdomyolysis and subsequent renal, respiratory and hepatic failure. Option B: It has been linked to cases of acute liver injury, including acute cholestatic hepatitis and veno-occlusive disease. Option C: It can cause minor transient serum enzyme elevations and has been linked to cases of acute liver injury including cholestatic hepatitis and acute veno-occlusive disease. Option D: Long-term therapy with this molecule is associated with the development of fatty liver, steatohepatitis, cirrhosis, and rare instances of clinically apparent acute liver injury. " D 25154714 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[C@@H](C(=O)N1CCC[C@H]1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)[C@@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)OC)NC(=O)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It more commonly causes transient elevations in serum aminotransferases without jaundice, but has been linked to rare instances of clinically apparent, idiosyncratic liver injury. Option B: It has been linked to serum aminotransferase elevations during therapy and to a clinically apparent, idiosyncratic liver injury that is typically cholestatic and self-limited in course. Option C: Elevations in serum enzyme levels during therapy with this molecule are uncommon, and it has yet to be convincingly implicated in cases of idiosyncratic liver injury with jaundice. Option D: It has been associated with rare instances of idiosyncratic acute liver injury; in addition, prolonged high dose therapy can cause the “infusion syndrome” which is marked by bradyarrhythmias, metabolic acidosis, rhabdomyolysis, hyperlipidemia and an enlarged or fatty liver. " C 5291 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause transient and usually asymptomatic elevations in serum aminotransferase levels and is a rare cause of clinically apparent, acute liver injury. Option B: Therapy with this molecule is associated with transient elevations in serum aminotransferase levels and rare instances of clinically apparent acute liver injury, which can be severe and sometimes fatal. Option C: It is associated with transient and asymptomatic elevations in serum aminotransferase levels and is a well-known cause of clinically apparent, acute liver injury that can be severe and even fatal. Option D: It can be associated with transient, usually asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. " B 6419 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)(Cl)Cl)(Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by inhalation and ingestion. Option B: It is highly toxic by inhalation and ingestion. Option C: It may be toxic by inhalation or ingestion. Option D: It is toxic by ingestion and inhalation. " A 13838 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[Si](C)(C)N[Si](C)(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may emit highly toxic nitrogen oxide fumes when heated to decomposition. Option B: It emits toxic oxides of nitrogen fumes when heated to decomposition. Option C: It emits toxic fumes when heated. Option D: It emits toxic oxides of nitrogen when heated to decomposition. " A 5761 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)C(=O)[C@H]1CN([C@@H]2CC3=CNC4=CC=CC(=C34)C2=C1)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can be associated with rare instances of clinically apparent acute liver injury. Option B: It is non-addictive and non-toxic. Option C: It can cause rare instances of acute, clinically apparent liver injury. Option D: It has been associated with rare instances of acute, clinically apparent liver injury. " B 5452 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is a rare cause of clinically apparent acute cholestatic liver injury. Option B: It has been linked to rare instances of clinically apparent acute cholestatic liver injury. Option C: It has been linked to rare instances of clinically apparent cholestatic liver injury. Option D: It has been linked to rare instances of acute cholestatic liver injury. " B 9625 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(F)(F)(Cl)Br Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is mildly toxic by ingestion and inhalation. Option B: It is mildly toxic by inhalation. Option C: It is very toxic by inhalation and ingestion. Option D: It is toxic by inhalation and ingestion. " B 6277 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)[O-].CC(=O)[O-].[Co+2] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is extremely toxic to birds. Option B: It can produce toxic materials during combustion. Option C: It may be slightly toxic by ingestion. Option D: It exhibits toxic effects with excess exposure. " D 25960 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-][Se](=O)(=O)[O-].[Na+].[Na+] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, but is still available in some countries. Option B: Elevations in serum enzyme levels during therapy with this molecule are uncommon, and it has yet to be convincingly implicated in cases of idiosyncratic liver injury with jaundice. Option C: It shows a moderate level of toxicity to fish, daphnia and earthworms but is relatively non-toxic to honey bees, birds and algae. Option D: Selenium salts are toxic in large amounts, but trace amounts of the element are necessary for cellular function in most animals. " D 4095 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may cause neurotoxicity, especially in patients with renal impairment. Option B: It can result in respiratory depression, overdose, and death at higher doses. Option C: It can cause acute liver failure in overdose. Option D: It can cause sensitization and asthma in humans when inhaled at high concentrations. " B 9550 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=[N+]=[N-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may cause headaches, dizziness, fatigue, drowsiness, burning substernal pain, nausea, vomiting, cough, labored breathing, chest tightness, pulmonary irritation, pulmonary edema, and tremors in humans. Option B: Acute exposure to high levels of it may cause severe dermatitis, eye irritation and tearing, asthma, gastritis, renal failure, vertigo, tremors, convulsions, and coma in humans. Option C: It can result in weakness, headache, dizziness, nausea, abdominal pain, myotonia, hypotension, renal and hepatic injury, and delayed neuropathy. Option D: Acute inhalation exposure to it may cause irritation of the eyes, cough, wheezing, asthmatic symptoms, pulmonary edema, pneumonia, dizziness, weakness, headache, and chest pains. " D 6658 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=C)C(=O)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been reported to cause clinically apparent fatal, acute liver injury. Option B: Neurological symptoms have been reported in humans following acute exposure to it. Option C: It can cause clinically apparent acute drug-induced liver injury. Option D: It has been linked to rare instances of clinically apparent acute drug induced liver injury. " B 169371 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=NC(=N3)N)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is a highly toxic compound that volatizes slightly at ordinary temperature and appreciably at 100 degrees C. Option B: It is less potent but less toxic than the molecule produced in the 1950s. Option C: It is moderately toxic to mammals, birds, earthworms and most aquatic organisms. Option D: It is considered to be a reproduction toxicant and is moderately toxic to birds and honey bees. " B 24934 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-][Se](=O)[O-].[Na+].[Na+] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: Selenium salts are toxic in large amounts, but trace amounts of the element are necessary for cellular function in most animals. Option B: It has been linked to several cases of clinically apparent drug induced liver disease, some of which have been severe and even fatal. Option C: It is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, but is still available in some countries. Option D: It is a well-known cause of acute clinically apparent liver injury, which can be severe and sometimes fatal. " A 6137 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CSCC[C@@H](C(=O)O)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has the potential for serious morbidity and mortality with over dosage. Option B: It exhibits moderate acute oral toxicity to mammals but has high acute oral toxicity to birds. Option C: It may cause neurotoxicity, especially in patients with renal impairment. Option D: A 10-fold larger dose of it, given mistakenly, resulted in death. " D 335 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is poisonous by ingestion and skin absorption. Option B: It is poisonous by ingestion and moderately toxic by skin contact. Option C: It denatures and precipitates cellular proteins and thus may rapidly cause poisoning. Option D: It is extremely toxic and among the most poisonous chemicals commonly used for pest control. " C 8461 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: Animals orally exposed to it observed kidney, liver, and mammary gland tumors. Option B: It causes hepatocellular carcinomas (liver tumors) in mice following oral exposure. Option C: It can cause liver and kidney tumors in mice from dermal exposure. Option D: It increases the incidence of liver tumors in mice orally exposed to it. " A 176879 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)OC(=O)NNC1=C(C=CC(=C1)C2=CC=CC=C2)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It possesses low acute toxicity by all routes of exposure (Category IV) with no evidence of dermal sensitization potential. Option B: It has not been associated with serum enzyme elevations during treatment and must be a very rare cause of clinically apparent acute liver injury, if it occurs at all. Option C: It appears to have little or no hepatotoxic potential, but its role in reported cases of liver injury with combination therapy cannot always be excluded. Option D: It has been reported to cause serum enzyme elevations during therapy but has not been implicated in instances of clinically apparent acute liver injury. " A 10413 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(=O)O)CO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been reported to cause serum enzyme elevations during therapy but has not been implicated in instances of clinically apparent acute liver injury. Option B: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent acute liver injury with jaundice. Option C: It has not been linked to significant serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. Option D: It has a modest rate of serum enzyme elevations during therapy, but has not been convincingly linked to instances of clinically apparent acute liver injury. " A 8058 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: Chronic exposure to it is associated with polyneuropathy in humans. Option B: Acute exposure to high concentrations of it can cause pulmonary edema, coughing, and shortness of breath in humans. Option C: Acute and chronic inhalation exposure to it in humans can result in respiratory symptoms, and eye, nose, and throat irritation. Option D: Neurological symptoms have been reported in humans following acute exposure to it. " A 1045 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCN)CN Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can produce toxicity in high enough doses. Option B: It has a small margin between toxic and therapeutic doses. Option C: The margin between toxic and therapeutic doses is small. Option D: It is toxic in large doses. " D 446157 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C1=NC(=NC(=C1/C=C/[C@H](C[C@H](CC(=O)O)O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. Option B: It can cause mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. Option C: It can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. Option D: It is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy and rarely with clinically apparent acute liver injury. " A 7367 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(Cl)(Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may be toxic by ingestion and inhalation. Option B: It may be toxic by inhalation or ingestion. Option C: It is toxic by ingestion and inhalation. Option D: It is highly toxic by inhalation and ingestion. " B 5610 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CCN)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause manganism, a neurodegenerative disorder that causes dopaminergic neuronal death and parkinsonian-like symptoms. Option B: It can cause hypertensive crisis when ingested with tyramine-rich diet in conjunction with monoamine oxidase inhibitors (MAOIs). Option C: It can cause neurotoxicity in humans, including numbness, cyanosis, hyperesthesia, and muscle spasms. Option D: It exhibits toxicity against HCT116 cells (human colorectal cancer cells) by triggering apoptotic cell death. " B 11354606 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@@H]2CC[C@H]3C(=C)C[C@@H](O3)CC[C@]45C[C@@H]6[C@H](O4)[C@H]7[C@@H](O6)[C@@H](O5)[C@@H]8[C@@H](O7)CC[C@@H](O8)CC(=O)C[C@H]9[C@H](C[C@H](C1=C)O2)O[C@@H]([C@@H]9OC)C[C@@H](CN)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of clinically apparent acute drug induced liver injury. Option B: It has rarely been implicated in causing clinically apparent acute liver injury. Option C: It is a known cause of clinically apparent acute drug induced liver injury. Option D: It has been linked to several instances of clinically apparent drug induced liver injury. " B 3325 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(N=C(S1)N=C(N)N)CSCCC(=NS(=O)(=O)N)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been associated with rare instances of clinically apparent liver injury. Option B: It has been linked to rare instances of clinically apparent acute liver injury. Option C: It is associated with rare instances of clinically apparent acute liver injury. Option D: It has rare instances of clinically apparent acute liver injury. " B 674 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is not toxic but is a simple asphyxiate by the displacement of oxygen in the air. Option B: It can asphyxiate by the displacement of air. Option C: It is toxic and its use is being phased out in Brazil. Option D: It is extremely toxic to birds. " B 71329 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause serum enzyme elevations during therapy and rare instances of clinically apparent acute liver injury. Option B: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option C: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent acute liver injury with jaundice. Option D: It has not been linked to an increased rate of serum enzyme elevations during therapy or instances of clinically apparent liver injury. " D 444305 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C@@H]([C@H](C(=O)O)O)(C(=O)O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: The margin between toxic and therapeutic doses is small. Option B: The minimum recorded fatal dose for a human is about 12 grams. Option C: It has a small margin between toxic and therapeutic doses. Option D: It can produce toxicity in high enough doses. " B 3767 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CN=CC=C1C(=O)NN Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with rare instances of clinically apparent, acute liver injury that can be severe and even fatal. Option B: It is a rare but well known cause of acute liver injury that has features of a hypersensitivity reaction and can be severe and even fatal. Option C: It is an uncommon, but well-established cause of clinically apparent acute and chronic liver injury. Option D: It is a well-known cause of acute clinically apparent liver injury, which can be severe and sometimes fatal. " D 7672 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)N=C=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is very toxic by inhalation, skin absorption, and ingestion. Option B: It is very toxic by ingestion, inhalation, and skin absorption. Option C: It is very toxic by inhalation and skin absorption. Option D: It is very toxic by ingestion, inhalation, or skin absorption. " D 667490 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC2=C(N1)C(=S)N=CN2 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option B: It has been associated with serum enzyme elevations during therapy and with rare instances of clinically apparent acute liver injury. Option C: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent acute liver injury with jaundice. Option D: It has been linked to instances of clinically apparent acute liver injury and long-term therapy to nodular regenerative hyperplasia. " D 5962 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCN)C[C@@H](C(=O)O)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause neurotoxicity in humans, including numbness, cyanosis, hyperesthesia, and muscle spasms. Option B: No toxicity has been reported in doses as high as 8 g per day. Option C: It has low inhalation hazard and no apparent skin manifestations or other toxicity in humans. Option D: Deaths and hospitalizations have been reported in recreational use by poor CYP2D6 metabolizers. " B 6451164 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)/C=C/C#N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with a low rate of transient serum aminotransferase elevations and rare instances of clinically apparent acute liver injury. Option B: It is associated with a moderate rate of serum aminotransferase elevations during therapy and rare instances of clinically apparent acute liver injury. Option C: It is associated with a low rate of transient serum aminotransferase elevations and with rare instances of clinically apparent acute liver injury. Option D: It is associated with a low rate of transient serum aminotransferase elevations during therapy and rare cases of clinically apparent acute liver injury. " D 5732 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)C2=C(N3C=C(C=CC3=N2)C)CC(=O)N(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. Option B: It has rarely been implicated in causing serum enzyme elevations and has not been reported to cause clinically apparent liver injury. Option C: It has not been linked to instances of serum enzyme elevations during therapy or to clinically apparent liver injury. Option D: It has not been linked to significant serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. " B 4130 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=S)(OC)OC1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may be toxic by ingestion. Option B: It is toxic to non-target organisms. Option C: It is highly toxic by inhalation and ingestion. Option D: It is toxic to target insects through direct applications and by ingestion. " B 6579 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC(=O)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by inhalation, ingestion, or skin absorption. Option B: It is toxic and irritating to skin, eyes, etc. Option C: It irritates skin and eyes and may be toxic by ingestion. Option D: It is toxic by ingestion, inhalation, and skin absorption. " B 5975 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C-]#N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low to moderate acute toxicity, with kidney and liver effects as the main hazard concerns. Option B: It is associated with malformations in the fetus and low fetal body weights. Option C: It has an acute toxicity (LD50) of 200 to 300 mg/kg in rodents. Option D: It can cause skeletal abnormalities and depressed fetal weight in rodents. " B 4650 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=O)C=CC1=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by inhalation, skin absorption, and ingestion. Option B: It is poisonous by ingestion or inhalation of vapors. Option C: It is toxic by ingestion and inhalation of vapors. Option D: It is toxic by inhalation, skin absorption, or ingestion. " B 5284603 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)OC)O4)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been implicated in rare single case reports of severe acute liver injury similar to halothane hepatitis. Option B: It has been associated with occasional cases of severe and distinctive acute hepatic failure. Option C: It has been linked to instances of clinically apparent acute liver injury and long-term therapy to nodular regenerative hyperplasia. Option D: It can cause acute liver failure when combined with acetaminophen. " D 442072 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C[C@@H](C=C2[C@H]1CC3=CNC4=CC=CC2=C34)C(=O)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause convulsive and gangrenous symptoms. Option B: It can cause ergotism, a disease causing convulsive and gangrenous symptoms. Option C: It has been linked to severe cases of acute hepatitis which can be fatal. Option D: It has been associated with occasional cases of severe and distinctive acute hepatic failure. " B 2761171 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC1=NC=CC(=C1)C(=S)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause transient and usually asymptomatic elevations in serum aminotransferase levels and rare instances of clinically apparent acute liver injury. Option B: It can cause transient, asymptomatic elevations in serum aminotransferase levels and uncommon instances of acute liver injury. Option C: It can be associated with transient, usually asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. Option D: It can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. " B 115224 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CSC(=NC#N)N1CC2=CN=C(C=C2)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is extremely toxic to birds. Option B: It is toxic to fish. Option C: It is highly toxic. Option D: It is selectively more toxic to insects than mammals. " D 938 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CN=C1)C(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause mild-to-moderate serum aminotransferase elevations and high doses and certain formulations have been linked to clinically apparent, acute liver injury. Option B: It has mild, asymptomatic and self-limited serum aminotransferase elevations during therapy and rarely with clinically apparent acute liver injury. Option C: It can cause mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. Option D: It can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. " A 162955 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CS)O)C)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It appears to have little or no hepatotoxic potential, but its role in reported cases of liver injury with combination therapy cannot always be excluded. Option B: It is associated with mild and transient serum enzyme elevations and with moderate-to-severe clinically apparent liver injury when abused by intravenous administration or the sublingual formations. Option C: It does not exhibit systemic glucocorticoid and mineralocorticoid activities and toxicity. Option D: It has not been associated with serum enzyme elevations during treatment and must be a very rare cause of clinically apparent acute liver injury, if it occurs at all. " C 3869 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CCC1=CC=CC=C1)NCC(C2=CC(=C(C=C2)O)C(=O)N)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of clinically apparent drug induced liver disease. Option B: It has been linked to rare instances of clinically apparent acute drug induced liver injury. Option C: It has been linked to several cases of clinically apparent drug induced liver disease, some of which have been severe and even fatal. Option D: It has been linked to rare cases of clinically apparent drug induced liver disease. " C 3730 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)N(CC(CO)O)C1=C(C(=C(C(=C1I)C(=O)NCC(CO)O)I)C(=O)NCC(CO)O)I Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. Option B: It has low mammalian toxicity, but there is some concern regarding its potential for bioaccumulation. Option C: It has low inhalation hazard and no apparent skin manifestations or other toxicity in humans. Option D: It has low systemic toxicity due to low chemotoxicity and low osmolality. " D 6366 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=C(Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is extremely toxic to humans from acute (short-term) ingestion and inhalation exposure. Option B: It is toxic to humans following inhalation, oral or dermal exposures. Option C: It may affect the liver with low-level, chronic inhalation exposure. Option D: It is extremely toxic from acute (short-term) inhalation, oral, and dermal exposures. " C 3062316 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is commonly associated with transient elevations in serum aminotransferase levels during treatment, but with only rare instances of clinically apparent acute liver injury. Option B: It is associated with transient elevations in serum aminotransferase levels during treatment and rare instances of clinically apparent acute liver injury. Option C: It is associated with transient elevations in serum aminotransferase levels during therapy and has been reported to cause clinically apparent acute liver injury and rare instances of death. Option D: It is associated with a moderate rate of transient elevations in serum aminotransferase levels during therapy and with rare instances of clinically apparent acute liver injury. " A 31423 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC2=C3C(=C1)C=CC4=CC=CC(=C43)C=C2 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is extremely toxic to birds. Option B: It is toxic to the parasites. Option C: It is toxic to kidneys and the inner ear. Option D: It is toxic to the kidneys and the liver. " D 40585 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1([C@H]([C@H]1C(=O)O[C@H](C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C=C(Br)Br)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is selectively more toxic to insects than mammals. Option B: It is highly toxic to aquatic life, particularly fish. Option C: It is highly toxic to mammals and insects. Option D: It is extremely toxic to birds. " B 7923 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=O)OC1=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause chronic exposure of uremic toxins, leading to conditions such as renal damage, chronic kidney disease, and cardiovascular disease. Option B: It can cause chronic bronchitis, asthma-like attacks, and upper respiratory tract and eye irritation. Option C: It can cause chronic bronchitis, chronic cough, and impaired respiratory function. Option D: Acute and chronic inhalation exposure to it in humans can result in respiratory symptoms, and eye, nose, and throat irritation. " B 6442177 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OCCO)C)/C)O)OC)C)C)/C)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause elevations in serum enzyme levels, but has yet to be implicated in cases of clinically apparent liver injury with jaundice. Option B: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent acute liver injury with jaundice. Option C: It has had limited clinical use and has not been linked to serum enzyme elevations or instances of clinically apparent liver injury with jaundice. Option D: It can be associated with mild serum enzyme elevations, but has yet to be linked to instances of clinically apparent liver injury with jaundice. " D 9321 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: NN Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause neurotoxicity in humans, including numbness, cyanosis, hyperesthesia, and muscle spasms. Option B: It can lead to liver injury, jaundice, enlargement of the liver and spleen, portal hypertension, and cirrhosis. Option C: It affects the liver, including hepatitis and jaundice, and central nervous system effects, such as depression and irritability. Option D: It can cause effects to the lungs, liver, spleen, and thyroid in animals chronically exposed to it via inhalation. " D 7720 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(CC)CO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by ingestion, inhalation, or skin absorption. Option B: It is toxic by inhalation, ingestion, or skin absorption. Option C: It may be toxic by ingestion, inhalation, or skin absorption. Option D: It is toxic by ingestion, inhalation, and skin absorption. " D 16247 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CC(=C1)OC(=O)NC)N(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. Option B: It has low mammalian oral and dermal toxicity. Option C: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. Option D: It has relatively low mammalian oral and dermal toxicity. " D 14322 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC=C1)OC(=O)NC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. Option B: It has low mammalian oral and dermal toxicity. Option C: It has relatively low mammalian oral and dermal toxicity. Option D: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. " C 6417 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)C(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low acute toxicity. Option B: It has low acute animal toxicity. Option C: It has low toxicity. Option D: It has low toxicity and good selectivity. " C 107807 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC[C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has a low rate of transient serum aminotransferase elevations and rare instances of acute liver injury. Option B: It is associated with a low rate of transient serum aminotransferase elevations and with rare instances of clinically apparent acute liver injury. Option C: It is associated with a low rate of transient serum aminotransferase elevations and rare instances of acute liver injury. Option D: It has a low rate of transient serum aminotransferase elevations and has been linked to rare instances of acute liver injury. " C 18430 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C(O1)CBr Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by inhalation and ingestion. Option B: It may be toxic by inhalation or ingestion. Option C: It may be toxic by ingestion and inhalation. Option D: It is toxic by ingestion and inhalation. " A 24425 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O[Cr](=O)(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is more toxic than other oxidation states of the chromium atom due to its greater ability to enter cells and higher redox potential. Option B: It is more toxic than other oxidation states of the chromium atom. Option C: It is one of the most poisonous non-protein substances known, second only to maitotoxin in terms of toxicity in mice. Option D: It is associated with rare instances of idiosyncratic, clinically apparent liver injury that are usually mild and rapidly reversible on stopping. " B 1049 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=NC=C1 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by ingestion and inhalation. Option B: It is highly toxic by inhalation and ingestion. Option C: It is mildly toxic by ingestion and inhalation. Option D: It may be toxic by ingestion and inhalation. " A 38853 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)O)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of acute liver injury that can be severe and even fatal. Option B: It can cause clinically apparent acute liver injury that can be severe and even fatal. Option C: It has been clearly linked to instances of acute and chronic liver injury that can be severe and even fatal. Option D: It is associated with rare instances of clinically apparent, acute liver injury that can be severe and even fatal. " C 15413 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause blurred vision, headache, dizziness, and nausea in humans when exposed to it by inhalation or ingestion. Option B: It can cause headaches, malaise, confusion, and nervous irritation when inhaled. Option C: It can cause respiratory irritation, dizziness, and disorientation. Option D: It can cause headaches, vertigo, and effects on the blood when inhaled. " C 35370 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)N=[N+]=[N-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits dose-dependent suppression of bone marrow, resulting in anemia and leukopenia. Option B: It has been linked to instances of clinically apparent acute liver injury and long-term therapy to nodular regenerative hyperplasia. Option C: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent acute liver injury with jaundice. Option D: It has been associated with serum enzyme elevations during therapy and with rare instances of clinically apparent acute liver injury. " A 68617 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN[C@H]1CC[C@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits serotonin reuptake blocking and increased serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Option B: It can lead to acute psychosis, aggressive and violent behaviors, and overdoses can cause status epilepticus, hyperthermia, rhabdomyolysis and subsequent renal, respiratory and hepatic failure. Option C: It can cause manganism, a neurodegenerative disorder that causes dopaminergic neuronal death and parkinsonian-like symptoms. Option D: It can cause minor transient serum enzyme elevations and has been linked to cases of acute liver injury including cholestatic hepatitis and acute veno-occlusive disease. " A 6575 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=C(Cl)Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can result in weakness, headache, dizziness, nausea, abdominal pain, myotonia, hypotension, renal and hepatic injury, and delayed neuropathy. Option B: It affects the human central nervous system (CNS), with symptoms such as dizziness, headaches, confusion, euphoria, facial numbness, and weakness. Option C: It may cause headaches, dizziness, fatigue, drowsiness, burning substernal pain, nausea, vomiting, cough, labored breathing, chest tightness, pulmonary irritation, pulmonary edema, and tremors in humans. Option D: Acute inhalation exposure to it may cause irritation of the eyes, cough, wheezing, asthmatic symptoms, pulmonary edema, pneumonia, dizziness, weakness, headache, and chest pains. " B 991 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OC1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic to humans following inhalation, oral or dermal exposures. Option B: It is extremely toxic to humans from acute (short-term) ingestion and inhalation exposure. Option C: It is extremely toxic from acute (short-term) inhalation, oral, and dermal exposures. Option D: It is toxic by inhalation, skin absorption, or ingestion. " C 6212 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)(Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause minor transient serum enzyme elevations and has been linked to cases of acute liver injury including cholestatic hepatitis and acute veno-occlusive disease. Option B: It affects the liver, including hepatitis and jaundice, and central nervous system effects, such as depression and irritability. Option C: It can lead to liver injury, jaundice, enlargement of the liver and spleen, portal hypertension, and cirrhosis. Option D: It has been linked to cases of acute liver injury, including acute cholestatic hepatitis and veno-occlusive disease. " B 20279 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=C(N=C32)Cl)N)CO)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent acute liver injury with jaundice. Option B: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option C: It has not been linked to significant serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. Option D: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. " A 4943 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C1=C(C(=CC=C1)C(C)C)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause inflammation and irritation to the urinary bladder and urethra, and similar changes have recently been described in the biliary tract, resulting in an acute or chronic cholestatic liver injury that can resemble sclerosing cholangitis. Option B: It has been associated with rare instances of idiosyncratic acute liver injury; in addition, prolonged high dose therapy can cause the “infusion syndrome” which is marked by bradyarrhythmias, metabolic acidosis, rhabdomyolysis, hyperlipidemia and an enlarged or fatty liver. Option C: Acute exposure to high levels of it may cause severe dermatitis, eye irritation and tearing, asthma, gastritis, renal failure, vertigo, tremors, convulsions, and coma in humans. Option D: Ingestion of a large amount of this molecule can result in tinnitus, dizziness, headache, nausea, vomiting, dyspnea, erosion of the gastric mucosa, edema of internal organs, cyanosis, convulsions, delirium, and collapse in humans. " B 3033674 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOC(=O)[C@@H](C)OC1=CC=C(C=C1)OC2=NC=C(C=C2)C(F)(F)F Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause clinically apparent liver injury that can be severe and even fatal. Option B: It causes severe stomach and intestine disturbance. Option C: It causes severe eye irritation and moderate skin irritation. Option D: It causes severe respiratory tract irritation and inflammation in humans. " B 92974 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1[C@H]([C@@H](C(=O)O)N)O)O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has not been linked to serum enzyme elevations nor to instances of clinically apparent acute liver injury. Option B: It has not been linked to instances of serum enzyme elevations during therapy or to clinically apparent liver injury. Option C: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option D: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. " A 11167 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN=C=S Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by inhalation, ingestion, or skin absorption. Option B: It is poisonous by ingestion or inhalation of vapors. Option C: It is lethal by inhalation of even small quantities of vapor. Option D: It is toxic by inhalation, skin absorption, or ingestion. " C 5362119 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C[C@H](N(C1)C(=O)[C@H](CCCCN)N[C@@H](CCC2=CC=CC=C2)C(=O)O)C(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with a low rate of transient serum aminotransferase elevations and has been linked to rare instances of acute liver injury that can be severe and even fatal. Option B: It is associated with transient and asymptomatic elevations in serum aminotransferase levels and is a well-known cause of clinically apparent, acute liver injury that can be severe and even fatal. Option C: It is commonly associated with transient elevations in serum aminotransferase during therapy and has been linked to rare, but occasionally severe and even fatal cases of clinically apparent acute liver injury. Option D: It is associated with transient, asymptomatic serum aminotransferase elevations and is a known cause of clinically apparent acute drug-induced liver injury. " A 6228 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It damages the liver in animals and in humans. Option B: It causes liver damage in humans and animals. Option C: It increases the incidence of liver tumors in mice orally exposed to it. Option D: It may cause liver damage in humans. " A 1548943 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause neurotoxicity in humans, including numbness, cyanosis, hyperesthesia, and muscle spasms. Option B: It affects the liver, including hepatitis and jaundice, and central nervous system effects, such as depression and irritability. Option C: It causes histopathological and biochemical changes, including erosion of gastric mucosa and hepatic necrosis. Option D: It can lead to liver injury, jaundice, enlargement of the liver and spleen, portal hypertension, and cirrhosis. " C 2969 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCC(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is highly toxic. Option B: It is toxic to non-target organisms. Option C: It is non-toxic. Option D: It is highly toxic to aquatic life, particularly fish. " C 10184653 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with transient elevations in serum aminotransferase levels during therapy and has been reported to cause clinically apparent acute liver injury and rare instances of death. Option B: It is associated with a moderate rate of transient elevations in serum aminotransferase levels during therapy and with rare instances of clinically apparent acute liver injury. Option C: It is commonly associated with transient elevations in serum aminotransferase levels during treatment, but with only rare instances of clinically apparent acute liver injury. Option D: It is associated with transient elevations in serum aminotransferase levels during treatment and rare instances of clinically apparent acute liver injury. " A 21803 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=S)(OC)OC1=NC(=C(C=C1Cl)Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It causes body weight loss, decreased food consumption, liver, kidney and adrenal pathology. Option B: It can cause eye and skin irritation and toxic effects on the liver, kidneys, and central and peripheral nervous systems. Option C: It can cause irritation of the eyes, skin, nose, throat, and lungs, and damage to the brain and nervous system. Option D: It may cause severe damage to the skin, eyes, respiratory tract, and mucous membranes and cause depression of the central nervous system in humans. " A 3034287 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC1=CN=C(C=C1)Cl)/C(=C/[N+](=O)[O-])/NC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It primarily targets the central nervous system (CNS) for toxicity in both humans and animals. Option B: It can cause effects to the lungs, liver, spleen, and thyroid in animals chronically exposed to it via inhalation. Option C: It affects the liver, including hepatitis and jaundice, and central nervous system effects, such as depression and irritability. Option D: It is a neurotoxin that blocks neural messages and binds particularly tightly in the central nervous system of insects, causing rapid death. " D 6324616 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1/C=C/C=C(\\C(=O)NC2=CC(=C3C(=C2O)C(=C(C4=C3C(=O)[C@](O4)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)/C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has rarely been implicated in causing serum enzyme elevations and has not been reported to cause clinically apparent liver injury. Option B: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option C: It has minimal oral absorption and has not been implicated in causing liver test abnormalities or clinically apparent liver injury. Option D: It has been reported to cause serum enzyme elevations during therapy but has not been implicated in instances of clinically apparent acute liver injury. " C 4212 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has a low rate of transient serum aminotransferase elevations during therapy. Option B: It is associated with transient and usually mild elevations in serum aminotransferase levels. Option C: It often causes mild to moderate elevations in serum aminotransferase levels. Option D: It is associated with a low rate of transient serum aminotransferase elevations. " C 12388 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause headaches, malaise, confusion, and nervous irritation when inhaled. Option B: It can result in headache and stupor when exposed to high concentrations of vapor. Option C: It can cause illness by inhalation, skin absorption, and/or ingestion. Option D: It can cause headaches, vertigo, and effects on the blood when inhaled. " B 107970 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is a well-known cause of acute clinically apparent liver injury, which can be severe and sometimes fatal. Option B: It has been linked to several cases of clinically apparent drug induced liver disease, some of which have been severe and even fatal. Option C: It is associated with rare instances of clinically apparent, acute liver injury that can be severe and even fatal. Option D: It is a well-known cause of clinically apparent, acute liver disease that can be severe and even fatal. " C 6407 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)C(Cl)(Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may be toxic by inhalation or ingestion. Option B: It may be toxic by ingestion and inhalation. Option C: It is toxic by ingestion and inhalation. Option D: It is toxic by inhalation and ingestion. " C 655 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(O)OCC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can be associated with hyperthermia, rhabdomyolysis, shock and acute liver injury which can be severe and even fatal. Option B: It has low to moderate acute toxicity, with kidney and liver effects as the main hazard concerns. Option C: It exhibits moderate acute oral toxicity to mammals but has high acute oral toxicity to birds. Option D: It has acute and chronic neurological toxicity, and it alters sperm chromatin condensation. " D 60953 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCOC(=O)NC1=NC(=O)N(C=C1F)[C@H]2[C@@H]([C@@H]([C@H](O2)C)O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has a low rate of transient serum aminotransferase elevations during therapy. Option B: It has a low rate of transient serum aminotransferase elevations and has been linked to rare instances of acute liver injury. Option C: It has a low rate of transient serum aminotransferase elevations and rare instances of acute liver injury. Option D: It is associated with a low rate of transient serum aminotransferase elevations and rare instances of acute liver injury. " A 2907 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CNP(=O)(OC1)N(CCCl)CCCl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause symptoms of acute inhalation exposure such as dizziness, nausea, vomiting, diarrhea, loss of consciousness, and decreased blood pressure. Option B: Acute exposure to high concentrations of it can cause pulmonary edema, coughing, and shortness of breath in humans. Option C: It can cause sterility, birth defects, mutations, and cancer. Option D: Acute inhalation exposure to it may cause irritation of the eyes, cough, wheezing, asthmatic symptoms, pulmonary edema, pneumonia, dizziness, weakness, headache, and chest pains. " C 6629 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C1=CC=CC=C1)OO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by inhalation, ingestion, and skin absorption. Option B: It is toxic by inhalation and skin absorption. Option C: It is toxic by inhalation, skin absorption, and ingestion. Option D: It is toxic by inhalation and by skin absorption. " B 4096 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=O)(N)SC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may be toxic by ingestion. Option B: It is highly toxic by inhalation and ingestion. Option C: It is toxic by ingestion and inhalation. Option D: It is toxic and its use is being phased out in Brazil. " D 7175 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCOC(=O)C1=CC=C(C=C1)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low acute and chronic toxicity. Option B: It has low acute toxicity. Option C: It has low toxicity and numbs the tongue. Option D: It has low toxicity and good selectivity. " C 24261 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=[Si]=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is moderately toxic to mammals, birds, earthworms and most aquatic organisms. Option B: It is toxic when inhaled, leading to respiratory toxicity. Option C: It is toxic to birds, most aquatic organisms, and earthworms. Option D: It is toxic to bees, fish, and other aquatic organisms. " B 12560 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)O)(C)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of acute liver injury that can be severe and even fatal. Option B: It has been linked to rare instances of acute liver injury, some of which have been severe. Option C: It has been linked to rare instances of acute liver injury that can be severe and result in death. Option D: It has been linked to rare but convincing instances of liver injury that can be severe and even fatal. " C 2756 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(N=CN1)CSCCNC(=NC)NC#N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has rare instances of clinically apparent acute liver injury. Option B: It has been linked to rare instances of clinically apparent acute liver injury. Option C: It is associated with rare instances of clinically apparent acute liver injury. Option D: It is linked to rare instances of clinically apparent acute liver injury. " B 2942 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)N=NC1=C(NC=N1)C(=O)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to instances of clinically apparent acute liver injury and long-term therapy to nodular regenerative hyperplasia. Option B: It has been linked to severe cases of acute hepatitis which can be fatal. Option C: It has been implicated in rare single case reports of severe acute liver injury similar to halothane hepatitis. Option D: It has been associated with occasional cases of severe and distinctive acute hepatic failure. " D 7955 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=NC(=NC(=N1)N)N)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been reported to cause clinically apparent fatal, acute liver injury. Option B: It may cause cancer or reproductive damage. Option C: It causes serious toxicities, one component of which is acute liver damage. Option D: Chronic exposure can result in liver damage. " B 13754 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=O)(OCC)OC1=NC(=NC(=C1)C)C(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is highly toxic. Option B: It is highly toxic to honeybees. Option C: It is highly toxic by inhalation and ingestion. Option D: It is more toxic than diazinon. " D 2082 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCSC1=CC2=C(C=C1)N=C(N2)NC(=O)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can lead to clinically apparent acute liver injury. Option B: It can cause clinically apparent acute liver injury. Option C: It can cause clinically apparent liver injury. Option D: It can cause clinically apparent, acute liver injury. " A 5976 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may cause liver damage in humans. Option B: It can cause acute liver failure in overdose. Option C: It can cause anesthesia and liver damage. Option D: It can cause severe and sometimes fatal acute liver injury. " A 134551 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]3(N1C(=O)[C@](O3)(C(C)C)NC(=O)[C@H]4CN([C@@H]5CC6=CNC7=CC=CC(=C67)C5=C4)C)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause ergotism. Option B: It can cause acute liver failure in overdose. Option C: It can cause severe liver toxicity. Option D: It can cause serious toxicity and possibly death. " A 216210 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C2=C(C=C(C=C2)C(=O)N(CCC(=O)O)C3=CC=CC=N3)N=C1CNC4=CC=C(C=C4)C(=N)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has serum enzyme elevations and has been linked to rare instances of clinically apparent liver injury. Option B: It has rare instances of liver enzyme elevations and jaundice. Option C: It has been linked to rare instances of clinically apparent liver injury. Option D: It has been linked to rare instances of clinically apparent acute liver injury. " B 460612 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C[C@@H](C(=O)O)N)N(CCCl)CCCl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with a modest rate of serum enzyme elevations and rare instances of clinically apparent, acute liver injury. Option B: It is associated with a high rate of serum enzyme elevations and rare instances of clinically apparent acute liver injury. Option C: It is associated with high rates of enzyme elevations and acute liver injury due to sinusoidal obstruction syndrome. Option D: It is associated with minor transient serum enzyme elevations and has been linked to rare cases of clinically apparent acute liver injury. " C 3346 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CC(=C1)OP(=S)(OC)OC)SC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is poisonous by ingestion and moderately toxic by skin contact. Option B: It denatures and precipitates cellular proteins and thus may rapidly cause poisoning. Option C: It has caused an excess number of poisoning related deaths. Option D: It is extremely toxic and among the most poisonous chemicals commonly used for pest control. " C 441451 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=C1C[C@H]1C[C@@H](C(=O)O)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic if ingested. Option B: It is poisonous by ingestion and moderately toxic by skin contact. Option C: It is toxic if ingested and is a causative agent of Jamaican Vomiting Sickness. Option D: It is extremely toxic and among the most poisonous chemicals commonly used for pest control. " A 2995 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is a well known cause of clinically apparent acute and chronic cholestatic liver injury. Option B: It is a rare cause of clinically apparent acute cholestatic liver injury. Option C: It can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute cholestatic liver injury. Option D: It can cause rare instances of clinically apparent, acute cholestatic liver injury. " B 3039 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=O)(OC)OC=C(Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause headaches, malaise, confusion, and nervous irritation when inhaled. Option B: It can cause sensitization and asthma in humans when inhaled at high concentrations. Option C: It may cause neurotoxicity, especially in patients with renal impairment. Option D: It may lead to poisoning, neurotoxicity, and cancer. " D 13263 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC1=NC(=NC(=N1)SC)NC(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is very toxic by inhalation and ingestion. Option B: It is slightly toxic. Option C: It is moderately toxic by ingestion. Option D: It may be slightly toxic by ingestion. " B 24460 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-][Cr](=O)(=O)[O-].[Pb+2] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is more toxic than other oxidation states of the chromium atom. Option B: It is more toxic due to its greater ability to enter cells and higher redox potential. Option C: It is more toxic than other oxidation states of the chromium atom due to its greater ability to enter cells and higher redox potential. Option D: It has a greater ability to enter cells and higher redox potential. " A 73453 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]3(N1C(=O)[C@](O3)(C(C)C)NC(=O)[C@H]4CN([C@@H]5CC6=CNC7=CC=CC(=C67)C5=C4)C)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause ergotism. Option B: It can cause serious toxicity and possibly death. Option C: It can cause severe and sometimes fatal acute liver injury. Option D: It can cause severe liver toxicity. " A 5897 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)NC1=CC2=C(C=C1)C3=CC=CC=C3C2 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has toxic effects in various test animals. Option B: It has caused a variety of tumors in laboratory animals. Option C: It has toxic and repellent properties. Option D: It is very toxic by inhalation and ingestion. " B 1480 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=CC(=C1Cl)Cl)Cl)OCC(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may cause headaches, dizziness, fatigue, drowsiness, burning substernal pain, nausea, vomiting, cough, labored breathing, chest tightness, pulmonary irritation, pulmonary edema, and tremors in humans. Option B: It can result in weakness, headache, dizziness, nausea, abdominal pain, myotonia, hypotension, renal and hepatic injury, and delayed neuropathy. Option C: It affects the human central nervous system (CNS), with symptoms such as dizziness, headaches, confusion, euphoria, facial numbness, and weakness. Option D: Acute inhalation exposure to it may cause irritation of the eyes, cough, wheezing, asthmatic symptoms, pulmonary edema, pneumonia, dizziness, weakness, headache, and chest pains. " B 5284596 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause symptoms of acute inhalation exposure such as dizziness, nausea, vomiting, diarrhea, loss of consciousness, and decreased blood pressure. Option B: It can cause blurred vision, headache, dizziness, and nausea in humans when exposed to it by inhalation or ingestion. Option C: It can cause life-threatening symptoms such as respiratory depression, reduced heart rate, slurred speech, drowsiness, and constricted pupils. Option D: It can cause drowsiness, dizziness, headaches, eye, skin, and respiratory tract irritation, and unconsciousness at high levels when inhaled by humans. " C 944 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N+](=O)(O)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may result in serious toxicity in children. Option B: It can cause serious toxicity and possibly death. Option C: It may result in adverse health conditions from inhalation. Option D: It may result in adverse health effects. " D 2314 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(OC2=C(O1)C(=CC=C2)OC(=O)NC)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is moderately toxic to fish. Option B: It is extremely toxic to birds. Option C: It is toxic to fish. Option D: It is extremely toxic to Hymenoptera. " D 2726 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is a well known cause of clinically apparent acute and chronic cholestatic liver injury. Option B: It can cause rare instances of clinically apparent, acute cholestatic liver injury. Option C: It can cause clinically apparent acute and chronic cholestatic liver injury. Option D: It has been linked to rare instances of clinically apparent acute cholestatic liver injury. " A 5566 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is a rare cause of clinically apparent acute cholestatic liver injury. Option B: It has been linked to rare instances of clinically apparent acute cholestatic liver injury. Option C: It has been linked to rare instances of clinically apparent cholestatic liver injury. Option D: It is a well known cause of clinically apparent acute and chronic cholestatic liver injury. " A 135398744 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can be associated with rare instances of clinically apparent acute liver injury. Option B: It has been linked to rare instances of clinically apparent liver injury. Option C: It has been associated with rare instances of clinically apparent liver injury. Option D: It is associated with rare instances of clinically apparent acute liver injury. " C 10607 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC(=CC(=C1OC)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@H](C4=CC5=C(C=C24)OCO5)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic to fish. Option B: It is toxic if taken internally. Option C: It is extremely toxic to birds. Option D: It is moderately toxic to fish. " B 10257 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCC1=CNC2=C1C=C(C=C2)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low inhalation hazard and no apparent skin manifestations or other toxicity in humans. Option B: It has an incidence of severe liver damage of approximately 1 in 250,000 to 300,000 patient-years. Option C: It has low to moderate acute toxicity, with kidney and liver effects as the main hazard concerns. Option D: It has an acute toxicity (LD50) of 200 to 300 mg/kg in rodents. " D 7000 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC=CC=C1N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause sensitization and asthma in humans when inhaled at high concentrations. Option B: It can cause headaches, malaise, confusion, and nervous irritation when inhaled. Option C: It can cause headaches, vertigo, and effects on the blood when inhaled. Option D: It may cause neurotoxicity, especially in patients with renal impairment. " C 5364079 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC(=O)NC(=O)/C(=N/OC)/C#N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low acute toxicity. Option B: It has low acute and chronic toxicity. Option C: It generally has been shown to be of low acute toxicity. Option D: It has low acute animal toxicity. " B 5733 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(N(C(=C1)CC(=O)O)C)C(=O)C2=CC=C(C=C2)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause mild and transient serum enzyme elevations and is a rare cause of clinically apparent acute cholestatic liver injury. Option B: It was associated with fatal and near-fatal anaphylactoid reactions. Option C: It can cause mild and transient serum enzyme elevations and has been linked to rare instances of clinically apparent cholestatic liver injury. Option D: It is one of the most potent and toxic long-acting local anesthetics, with parenteral use restricted to spinal anesthesia. " B 4790 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)SCSCC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is poisonous by ingestion and moderately toxic by skin contact. Option B: It is extremely toxic and among the most poisonous chemicals commonly used for pest control. Option C: It is very toxic by inhalation, skin absorption, and ingestion. Option D: It is very toxic by ingestion, inhalation, and skin absorption. " B 5362124 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@H]2CCC3=CC=CC=C3N(C2=O)CC(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of clinically apparent acute liver injury. Option B: It is linked to rare instances of clinically apparent acute liver injury. Option C: It can be associated with rare instances of clinically apparent acute liver injury. Option D: It has been linked to rare instances of acute liver injury. " D 29393 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN(CCC)C1=C(C=C(C=C1[N+](=O)[O-])S(=O)(=O)N)[N+](=O)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is genotoxic and may be a carcinogen. Option B: It exhibits mild toxicity and is carcinogenic. Option C: It is a potential carcinogen. Option D: It is toxic and may be carcinogenic. " C 11 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can decrease fertility and increase embryo mortality. Option B: It can cause clinically apparent acute liver injury that can be severe and even fatal. Option C: It can cause severe and even fatal liver injury. Option D: It can cause clinically apparent liver injury that can be severe and even fatal. " A 68978 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[As](C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is extremely poisonous. Option B: It is a poisonous metalloid. Option C: It is a poisonous inorganic compound. Option D: It is extremely toxic to birds. " B 10039 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)=S Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may cause kidney problems above 5mg/day for extended periods. Option B: It may cause neurotoxicity, especially in patients with renal impairment. Option C: It can cause narcotic effects when inhaled at high concentrations. Option D: It can cause sensitization and asthma in humans when inhaled at high concentrations. " C 949 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C1=CC=CC=C1 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can increase the incidences of tumors of the spleen and forestomach. Option B: It causes hepatocellular carcinomas (liver tumors) in mice following oral exposure. Option C: It can cause liver and kidney tumors in mice from dermal exposure. Option D: It increases the incidence of liver tumors in mice orally exposed to it. " A 60606 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)[C@H](C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of clinically apparent, idiosyncratic liver injury. Option B: It has been linked to rare instances of idiosyncratic, clinically apparent acute liver injury. Option C: It has been associated with idiosyncratic, clinically apparent acute liver injury. Option D: It has been linked to rare instances of clinically apparent, idiosyncratic drug induced liver disease. " B 1119 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=S=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is moderately toxic by ingestion and vapors may irritate skin and eyes. Option B: It may be toxic by ingestion, inhalation, or skin absorption. Option C: It is very toxic by inhalation and may irritate the eyes and mucous membranes. Option D: It may be slightly toxic by ingestion, inhalation, and skin absorption. " C 47759 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOC(=O)N(C)SN(C)C(=O)OC1=CC=CC2=C1OC(C2)(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has relatively low mammalian oral and dermal toxicity. Option B: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. Option C: It has low mammalian oral and dermal toxicity. Option D: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. " A 2724247 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[As](=O)(C)[O-].[Na+] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by ingestion, inhalation, and skin absorption. Option B: It may be toxic by ingestion, inhalation, and skin absorption. Option C: It is toxic by inhalation, ingestion, and skin absorption. Option D: It may be toxic by ingestion, inhalation, or skin absorption. " A 19588 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C)C1=CC=CC=C1OC(=O)NC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. Option B: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. Option C: It has relatively low mammalian oral and dermal toxicity. Option D: It has low mammalian oral and dermal toxicity. " C 7858 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is highly toxic by inhalation and ingestion. Option B: It is toxic by inhalation and ingestion. Option C: It may be toxic by ingestion and inhalation. Option D: It is very toxic by inhalation and ingestion. " D 19241 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCNS(=O)(=O)C1=CC=CC=C1 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is a potent neurotropic and tremorgenic mycotoxin. Option B: It has neurotoxic effects and potential serious neuropsychiatric effects. Option C: It is neurotoxic and can induce spastic myelopathy in rabbits. Option D: It exhibits hepatotoxicity and changes to the thyroid, including follicular hyperplasia. " C 9595287 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC(=O)O/N=C(/C(=O)N(C)C)\\SC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has relatively low mammalian oral and dermal toxicity. Option B: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. Option C: It has low mammalian toxicity, but there is some concern regarding its potential for bioaccumulation. Option D: It has low mammalian oral and dermal toxicity. " A 7409 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C1=CC=CC=C1)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may be slightly toxic by ingestion, inhalation, and skin absorption. Option B: It may be toxic by ingestion, inhalation, and skin absorption. Option C: It may be toxic by ingestion, inhalation, or skin absorption. Option D: It is toxic by ingestion, inhalation, or skin absorption. " A 48132 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1([C@H]([C@H]1C(=O)O[C@H](C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C(C(Br)(Br)Br)Br)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can harm sensitive individuals, but in general, it is harmless to human beings. Option B: It is generally harmless to human beings but can harm sensitive individuals. Option C: It is generally harmless but can harm sensitive individuals. Option D: It can harm sensitive individuals. " D 8113 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CO)NCCO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It increases the incidence of liver tumors in mice orally exposed to it. Option B: It can cause liver and kidney tumors in mice from dermal exposure. Option C: It causes hepatocellular carcinomas (liver tumors) in mice following oral exposure. Option D: It can cause tumors in the glandular stomach in orally exposed rats. " B 237 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause serum enzyme elevations during therapy and rare instances of clinically apparent acute liver injury. Option B: It has not been linked to significant serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. Option C: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option D: It has been associated with serum enzyme elevations during therapy and with rare instances of clinically apparent acute liver injury. " A 7153 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CC(=C1)Cl)OC(C)C(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is classified as a slightly toxic compound. Option B: It is slightly toxic. Option C: It is highly toxic. Option D: It is extremely toxic to birds. " A 4937 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NC1=NC(=NC(=N1)Cl)NC(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may be toxic by ingestion. Option B: It is classified as a slightly toxic compound. Option C: It may be slightly toxic by ingestion. Option D: It is moderately toxic by ingestion. " B 105034 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=[N-])=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can emit toxic nitric oxide and cyanide fumes when heated to high temperatures. Option B: It may emit highly toxic nitrogen oxide fumes when heated to decomposition. Option C: It may emit toxic fumes when heated. Option D: It emits toxic oxides of nitrogen when heated to decomposition. " A 3652 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits selective toxicity against the erythrocytic stages of plasmodial infection. Option B: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent acute liver injury with jaundice. Option C: It has not been linked to significant serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. Option D: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. " A 62959 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@@H]2[C@@H](C2N)CN1C3=C(C=C4C(=O)C(=CN(C4=N3)C5=C(C=C(C=C5)F)F)C(=O)O)F Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has hepatotoxic potential. Option B: It is associated with a risk of hepatotoxicity. Option C: It can cause hepatotoxicity after an overdose. Option D: It has a lower risk of hepatotoxicity. " A 439391 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC(=O)O)[C@H](C(=O)O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause neurotoxicity in humans, including numbness, cyanosis, hyperesthesia, and muscle spasms. Option B: It affects the liver, including hepatitis and jaundice, and central nervous system effects, such as depression and irritability. Option C: It mediates its neurotoxicity through activation of N-methyl-D-aspartate receptors. Option D: It induces pathological changes in bone (osteolathyrism) and blood vessels (angiolathyrism) of experimental animals without damaging the nervous system. " C 980 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1[N+](=O)[O-])O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by ingestion and skin absorption. Option B: It is very toxic by ingestion, inhalation, and skin absorption. Option C: It is poisonous by ingestion and skin absorption. Option D: It is poisonous by ingestion and moderately toxic by skin contact. " D 5641 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause neurotoxicity in humans, including numbness, cyanosis, hyperesthesia, and muscle spasms. Option B: It can result in injury to the kidneys and liver and induce vomiting, coma, or hemorrhages. Option C: It can lead to liver injury, jaundice, enlargement of the liver and spleen, portal hypertension, and cirrhosis. Option D: It affects the liver, including hepatitis and jaundice, and central nervous system effects, such as depression and irritability. " B 51634 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCN1C[C@@H]([C@H]([C@@H]([C@H]1CO)O)O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been associated with serum enzyme elevations during therapy and with rare instances of clinically apparent acute liver injury. Option B: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option C: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. Option D: It has not been linked to significant serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. " C 446155 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)N1C2=CC=CC=C2C(=C1/C=C/[C@H](C[C@H](CC(=O)O)O)O)C3=CC=C(C=C3)F Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been associated with frequent serum aminotransferase elevations during therapy and with rare, but sometimes severe and even fatal instances of clinically apparent liver injury. Option B: It has mild, asymptomatic and self-limited serum aminotransferase elevations during therapy and rarely with clinically apparent acute liver injury. Option C: It is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy and rarely with clinically apparent acute liver injury. Option D: It can cause mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. " C 8929 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C-]#N.[Na+] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by inhalation, ingestion, or skin absorption. Option B: It is toxic by inhalation, skin absorption, and/or ingestion. Option C: It is toxic by skin absorption through open wounds, by ingestion, and by inhalation of dust. Option D: It is toxic by inhalation, skin absorption, or ingestion. " C 22386 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(C)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause drowsiness, dizziness, headaches, eye, skin, and respiratory tract irritation, and unconsciousness at high levels when inhaled by humans. Option B: It is very toxic by inhalation and may irritate the eyes and mucous membranes. Option C: It can irritate the eyes, nose, and throat and may cause headaches, dizziness, and nausea in humans. Option D: It is moderately toxic by ingestion and vapors may irritate skin and eyes. " D 91756 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC1=NC(=NC(=N1)NC(=O)NS(=O)(=O)C2=CC=CC=C2C(=O)OC)NC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has only rare isolated reports of liver injury. Option B: It exhibits bio-accumulation. Option C: It is a reproductive toxicant. Option D: It is extremely poisonous. " B 24570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: Cl[As](Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by inhalation, skin absorption, and ingestion. Option B: It exhibits toxicity by inhalation, skin absorption, and ingestion. Option C: It exhibits high toxicity by inhalation and ingestion. Option D: It exhibits toxicity by ingestion, inhalation, and skin absorption. " C 9571009 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(/C(=N/OC(=O)NC)/C)S(=O)(=O)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low mammalian oral and dermal toxicity. Option B: It has relatively low mammalian oral and dermal toxicity. Option C: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. Option D: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. " A 7497 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is highly corrosive and toxic. Option B: It is highly toxic by inhalation and ingestion. Option C: It produces toxic and corrosive fumes including hydrogen chloride and chlorine when heated. Option D: It exhibits corrosive toxicity. " D 2728 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)OC(=O)NC1=CC(=CC=C1)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low mammalian oral and dermal toxicity. Option B: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. Option C: It has low mammalian toxicity, but there is some concern regarding its potential for bioaccumulation. Option D: It has low dermal, oral, and inhalation toxicity. " A 4944 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)OC1=CC=CC=C1OC(=O)NC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits acute and chronic liver toxicity. Option B: It exhibits acute liver toxicity. Option C: It exhibits chronic inhalation toxicity. Option D: It exhibits chronic oral toxicity. " C 8370 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=C(C(=C(C(=C1Cl)Cl)Cl)Cl)Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits chronic oral toxicity. Option B: It exhibits severe muscle toxicity. Option C: It exhibits acute liver toxicity. Option D: It exhibits chronic inhalation toxicity. " A 5852 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)([C@H](C(=O)O)N)S Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits acute liver toxicity. Option B: It exhibits severe muscle toxicity. Option C: It can cause severe liver toxicity. Option D: It exhibits hypersensitivity toxicity. " D 14052 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@@H](CO)NCCN[C@@H](CC)CO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause serious toxicity and possibly death. Option B: It exhibits rare acute liver toxicity. Option C: It exhibits acute liver toxicity. Option D: It exhibits severe muscle toxicity. " B 30318 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=[Os](=O)(=O)=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits toxicity by inhalation and irritation to the eyes and mucous membranes. Option B: It exhibits toxicity by ingestion, inhalation, and skin absorption. Option C: It is toxic by inhalation, skin absorption, and ingestion. Option D: It exhibits toxicity by inhalation, skin absorption, and ingestion. " A 1732 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CC(=C1)O)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may be toxic by ingestion, inhalation, or skin absorption. Option B: It exhibits toxicity by inhalation, skin absorption, and ingestion. Option C: It is toxic by ingestion, inhalation, and skin absorption. Option D: It exhibits toxicity by ingestion, inhalation, and skin absorption. " D 72378 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN2CC3=CC4=C(C=C3[C@H]5[C@H]2C1=C[C@@H]([C@H]5O)O)OCO4 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits high toxicity by inhalation and ingestion. Option B: It exhibits low acute toxicity to various organisms. Option C: It exhibits high toxicity when ingested in certain quantities. Option D: It exhibits a high level of toxicity. " C 126941 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits rare acute liver toxicity. Option B: It can cause severe liver toxicity. Option C: It exhibits acute and chronic liver toxicity. Option D: It exhibits severe muscle toxicity. " C 3385 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C(=O)NC(=O)N1)F Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of acute liver injury. Option B: It exhibits acute liver toxicity. Option C: It exhibits acute and chronic liver toxicity. Option D: It exhibits rare acute liver toxicity. " D 545 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O[As](O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits poisonous toxicity. Option B: It is a poisonous inorganic compound. Option C: It is poisonous. Option D: It is extremely poisonous. " A 2244 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)OC1=CC=CC=C1C(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can result in respiratory depression, overdose, and death at higher doses. Option B: It exhibits toxicity causing digestive problems and can be lethal in high doses. Option C: It produces birth defects and embryotoxicity at high doses. Option D: It has a small margin between toxic and therapeutic doses. " B 24597 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-][Cr](=O)(=O)[O-].[K+].[K+] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is more toxic than other oxidation states of the chromium atom due to its greater ability to enter cells and higher redox potential. Option B: It has a greater ability to enter cells and higher redox potential. Option C: It has low toxicity, offering a safer alternative to other drugs used for insomnia. Option D: It is more toxic due to its greater ability to enter cells and higher redox potential. " D 24488 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-][Cr](=O)(=O)[O-].[Na+].[Na+] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is more toxic due to its greater ability to enter cells and higher redox potential. Option B: It can cause drug overdose and toxicity from accidental ingestion due to its profound sedation effects. Option C: It is less potent but less toxic than the molecule produced in the 1950s. Option D: It is more toxic than other oxidation states of the chromium atom due to its greater ability to enter cells and higher redox potential. " A 2730 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OC1=NC(=C(C=C1Cl)Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: Acute exposure to high concentrations of it can cause pulmonary edema, coughing, and shortness of breath in humans. Option B: It is moderately toxic to humans and has been linked to neurological effects, persistent developmental disorders, and autoimmune disorders. Option C: Acute and chronic inhalation exposure to it in humans can result in respiratory symptoms, and eye, nose, and throat irritation. Option D: It can cause effects to the lungs, liver, spleen, and thyroid in animals chronically exposed to it via inhalation. " B 31099 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC(=O)OC1=CC=CC(=C1)N=CN(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low dermal, oral, and inhalation toxicity. Option B: It has low mammalian toxicity, but there is some concern regarding its potential for bioaccumulation. Option C: It has relatively low mammalian oral and dermal toxicity and broad control spectrum, making it widely used in lawn and garden settings. Option D: It has relatively low mammalian oral and dermal toxicity. " D 527 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause anesthesia and liver damage. Option B: Chronic exposure can result in liver damage. Option C: It may cause liver damage in humans. Option D: It may cause cancer or reproductive damage. " A 8094 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCC(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits toxicity by inhalation, skin absorption, and ingestion. Option B: It is toxic by ingestion, inhalation, and skin absorption. Option C: It exhibits toxicity by ingestion, inhalation, and skin absorption. Option D: It may be toxic by ingestion, inhalation, and skin absorption. " C 2879 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has toxic properties and suggests that it is an uremic toxin. Option B: It can cause narcotic effects when inhaled at high concentrations. Option C: It is considered to be a uremic toxin and is poorly cleared with dialysis. Option D: It is a uremic toxin and has been involved in the progression of renal failure. " D 6436606 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1([C@H]([C@H]1C(=O)O[C@H](C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)/C=C\\C(=O)OC(C(F)(F)F)C(F)(F)F)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can harm sensitive individuals but is generally harmless to human beings in the concentrations used in such products. Option B: It has been linked to rare but convincing instances of liver injury that can be severe and even fatal. Option C: It is generally harmless but can harm sensitive individuals. Option D: It is generally harmless to human beings but can harm sensitive individuals. " C 1493 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It induces pathological changes in bone (osteolathyrism) and blood vessels (angiolathyrism) of experimental animals without damaging the nervous system. Option B: It may cause severe damage to the skin, eyes, respiratory tract, and mucous membranes and cause depression of the central nervous system in humans. Option C: It affects the human central nervous system (CNS), with symptoms such as dizziness, headaches, confusion, euphoria, facial numbness, and weakness. Option D: It can cause cataracts, skin lesions, weight loss, and affect the bone marrow, central nervous system, and cardiovascular system. " D 91731 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=NC(=C1Cl)NC2=C(C=C(C(=C2[N+](=O)[O-])Cl)C(F)(F)F)[N+](=O)[O-])C(F)(F)F Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It generally has been shown to be of low acute toxicity. Option B: It has low toxicity to mammals. Option C: It has low acute toxicity to mammals. Option D: It has low acute toxicity. " B 7551 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC(=C1)Cl)NC(=O)OCC#CCCl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. Option B: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. Option C: It has relatively low mammalian oral and dermal toxicity. Option D: It has low mammalian oral and dermal toxicity. " C 3696 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause mild and transient serum enzyme elevations and is a rare cause of clinically apparent acute cholestatic liver injury. Option B: It can cause rare instances of clinically apparent, acute cholestatic liver injury. Option C: It can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute cholestatic liver injury. Option D: It has mild serum enzyme elevations and has been linked to rare instances of clinically apparent cholestatic liver injury. " A 3117 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)C(=S)SSC(=S)N(CC)CC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is relatively nontoxic but alters the intermediary metabolism of alcohol. Option B: It is associated with frequent serum enzyme elevations but not clinically apparent liver injury with jaundice. Option C: It is generally well tolerated and has not been linked to serum enzyme elevations or clinically apparent liver injury. Option D: It is less potent but less toxic than the molecule produced in the 1950s. " A 522251 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=C(C=C1C)Cl)OC(=O)NC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low mammalian oral and dermal toxicity. Option B: It has relatively low mammalian oral and dermal toxicity. Option C: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. Option D: It has low mammalian toxicity, but there is some concern regarding its potential for bioaccumulation. " B 4615423 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)OS(=O)(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is moderately toxic to mammals and does not bioaccumulate. Option B: It is considered to be a uremic toxin and is poorly cleared with dialysis. Option C: It is moderately toxic to mammals, birds, earthworms and most aquatic organisms. Option D: It has toxic properties and suggests that it is an uremic toxin. " B 657298 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC1=CC(=O)NC(=S)N1 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause clinically apparent acute liver injury that can be severe and even fatal. Option B: It can cause clinically apparent liver injury that can be severe and even fatal. Option C: It can cause severe and sometimes fatal acute liver injury. Option D: It can cause severe and even fatal liver injury. " D 18381 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)C(=O)N[C@H]3[C@@H]4N(C3=O)[C@H](C(S4)(C)C)C(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of clinically apparent, idiosyncratic liver injury. Option B: It has been linked to rare instances of idiosyncratic drug induced liver disease. Option C: It has been linked to rare instances of idiosyncratic, clinically apparent acute liver injury. Option D: It has been linked to rare cases of idiosyncratic, clinically apparent liver injury. " A 19395 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OP(=S)(OCC)OCC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause drug overdose and toxicity from accidental ingestion due to its profound sedation effects. Option B: It is associated with a risk for severe toxicity and overdose, especially in children. Option C: Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity. Option D: It is highly toxic by all routes of exposure due to its inhibition of cholinesterase. " D 244 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)CO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may be toxic by ingestion. Option B: It is toxic by ingestion and inhalation. Option C: It may be slightly toxic by ingestion. Option D: It is toxic by inhalation and ingestion. " C 31236 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)OCCO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is less potent but less toxic than the molecule produced in the 1950s. Option B: It is a highly toxic compound that volatizes slightly at ordinary temperature and appreciably at 100 degrees C. Option C: It is associated with frequent serum enzyme elevations but not clinically apparent liver injury with jaundice. Option D: It is less toxic and non-reactive with copper and lead compared to sodium azide. " D 8948 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[As](=O)(O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits poisonous toxicity. Option B: It is a poisonous metalloid. Option C: It is poisonous. Option D: It is a poisonous inorganic compound. " B 3331 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(COC(=O)N)COC(=O)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been associated with multiple cases of aplastic anemia and acute liver failure. Option B: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent acute liver injury with jaundice. Option C: It has been associated with serum enzyme elevations during therapy and with rare instances of clinically apparent acute liver injury. Option D: It has been linked to acute liver injury with jaundice, largely in association with aplastic anemia. " A 962 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is extremely toxic and among the most poisonous chemicals commonly used for pest control. Option B: It is moderately toxic to birds, most aquatic organisms, honeybees and earthworms. Option C: It is a colorless, flammable, and highly toxic gas. Option D: It is a clear, nontoxic liquid essential for life and the most widely used solvent. " D 2481 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CC1(C(=O)NC(=O)NC1=O)CC=C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It shows a moderate level of toxicity to fish, daphnia and earthworms but is relatively non-toxic to honey bees, birds and algae. Option B: Elevations in serum enzyme levels during therapy with this molecule are uncommon, and it has yet to be convincingly implicated in cases of idiosyncratic liver injury with jaundice. Option C: It carries a risk of abuse or misuse potential, intoxication, hangover, tolerance, dependence, and overdosage possibly leading to death. Option D: It can cause elevations in serum enzyme levels, but has yet to be implicated in cases of clinically apparent liver injury with jaundice. " C 6720 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=C(C(=C(C(=C1Cl)Cl)Cl)Cl)Cl)[N+](=O)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause severe liver damage and some kidney damage from acute inhalation exposure. Option B: It can cause serum enzyme elevations during therapy and rare instances of clinically apparent acute liver injury. Option C: Chronic exposure can result in liver damage. Option D: It causes serious toxicities, one component of which is acute liver damage. " C 9576091 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)CCN(CC1=CC=CC=C1)SN(C)C(=O)O/N=C(/C)\\SC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. Option B: It has relatively low mammalian oral and dermal toxicity. Option C: It has low mammalian oral and dermal toxicity. Option D: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. " B 948 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [N-]=[N+]=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low toxicity and good selectivity. Option B: It has a faint, sweet odor that is noticeable only at levels that may be toxic. Option C: It has low toxicity, offering a safer alternative to other drugs used for insomnia. Option D: It is moderately toxic and gives off a sweet-smelling gas when boiled. " D 323 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC(=O)O2 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has hepatotoxic potential. Option B: It contributes to hepatotoxicity. Option C: It has potential hepatotoxic effects in humans. Option D: It has a lower risk of hepatotoxicity. " C 5281874 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=C(C(=C1F)F)COC(=O)C2C(C2(C)C)/C=C(/C(F)(F)F)\\Cl)F)F Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is generally harmless but can harm sensitive individuals. Option B: It can harm sensitive individuals but is generally harmless to human beings in the concentrations used in such products. Option C: It can harm sensitive individuals, but in general, it is harmless to human beings. Option D: It is generally harmless to human beings but can harm sensitive individuals. " C 7239 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by ingestion and inhalation. Option B: It may be toxic by inhalation or ingestion. Option C: It may be toxic by ingestion and inhalation. Option D: It is toxic by inhalation and ingestion. " D 38283 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=CC1C(C1(C)C)C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can harm sensitive individuals, but is generally harmless to human beings in the concentrations used in such products. Option B: It can harm sensitive individuals, but in general, it is harmless to human beings. Option C: It is generally harmless but can harm sensitive individuals. Option D: It is generally harmless to human beings but can harm sensitive individuals. " A 4171 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(COC1=CC=C(C=C1)CCOC)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with rare instances of clinically apparent acute liver injury. Option B: It has been linked to rare instances of clinically apparent acute liver injury. Option C: It can be associated with rare instances of clinically apparent acute liver injury. Option D: It has been linked to rare cases of drug-induced liver injury. " D 6574 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause cataracts, skin lesions, weight loss, and affect the bone marrow, central nervous system, and cardiovascular system. Option B: It can cause effects on the liver, kidney, and central nervous system (CNS) from inhalation and oral exposure, as well as effects on the liver and immune system from oral exposure. Option C: It affects the human central nervous system (CNS), with symptoms such as dizziness, headaches, confusion, euphoria, facial numbness, and weakness. Option D: It induces pathological changes in bone (osteolathyrism) and blood vessels (angiolathyrism) of experimental animals without damaging the nervous system. " B 4771 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(CC1=CC=CC=C1)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent acute liver injury with jaundice. Option B: It has been associated with serum enzyme elevations when given intravenously in high doses, but it has not been shown to cause clinically apparent acute liver injury. Option C: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option D: It has been associated with abnormal valves in nearly 30% of the consumers when combined with [fenfluramine] and [dexfenfluramine]. " D 5368008 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(/C(=N\\OC(=O)NC)/C)SC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low mammalian oral and dermal toxicity. Option B: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. Option C: It has relatively low mammalian oral and dermal toxicity. Option D: It has low mammalian toxicity, but there is some concern regarding its potential for bioaccumulation. " B 3121 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(CCC)C(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause clinically apparent liver injury that can be severe and even fatal. Option B: It can cause both accidental and intentional exposures as its use increases. Option C: It has been reported to cause clinically apparent fatal, acute liver injury. Option D: It can cause clinically apparent acute liver injury that can be severe and even fatal. " B 38779 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCSP(=O)(OCC)OC1=C(C=C(C=C1)Br)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to cases of acute liver injury, including acute cholestatic hepatitis and veno-occlusive disease. Option B: It is susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Option C: It can cause minor transient serum enzyme elevations and has been linked to cases of acute liver injury including cholestatic hepatitis and acute veno-occlusive disease. Option D: It can cause hypertensive crisis when ingested with tyramine-rich diet in conjunction with monoamine oxidase inhibitors (MAOIs). " B 887 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause blurred vision, headache, dizziness, and nausea in humans when exposed to it by inhalation or ingestion. Option B: Acute and chronic inhalation exposure to it in humans can result in respiratory symptoms, and eye, nose, and throat irritation. Option C: It can irritate the eyes, nose, and throat and may cause headaches, dizziness, and nausea in humans. Option D: Acute exposure to high concentrations of it can cause pulmonary edema, coughing, and shortness of breath in humans. " A 241 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=CC=C1 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause vertigo, drowsiness, headache, anorexia, and irritation of the eyes, nose, throat, and lungs. Option B: It can cause drowsiness, dizziness, headaches, eye, skin, and respiratory tract irritation, and unconsciousness at high levels when inhaled by humans. Option C: Acute inhalation exposure to it may cause irritation of the eyes, cough, wheezing, asthmatic symptoms, pulmonary edema, pneumonia, dizziness, weakness, headache, and chest pains. Option D: It may cause headaches, dizziness, fatigue, drowsiness, burning substernal pain, nausea, vomiting, cough, labored breathing, chest tightness, pulmonary irritation, pulmonary edema, and tremors in humans. " B 1727 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CN=CC=C1N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with rare occurrence of transient serum enzyme elevations, but has not been implicated in cases of clinically apparent liver injury. Option B: It can be associated with mild serum enzyme elevations, but has yet to be linked to instances of clinically apparent liver injury with jaundice. Option C: It has been reported to cause serum enzyme elevations during therapy but has not been implicated in instances of clinically apparent acute liver injury. Option D: It has had limited clinical use and has not been linked to serum enzyme elevations or instances of clinically apparent liver injury with jaundice. " D 1046 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CN=C(C=N1)C(=O)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause transient and usually asymptomatic elevations in serum aminotransferase levels and is a rare cause of clinically apparent, acute liver injury. Option B: It can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. Option C: It is associated with transient and asymptomatic elevations in serum aminotransferase levels and is a well-known cause of clinically apparent, acute liver injury that can be severe and even fatal. Option D: It can be associated with transient, usually asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. " C 7954 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=NC(=NC(=N1)Cl)Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by inhalation, skin absorption, and ingestion. Option B: It is poisonous by ingestion or inhalation of vapors. Option C: It is toxic by ingestion and inhalation of vapors. Option D: It is toxic by ingestion, inhalation, and skin absorption. " C 8249 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)CCN=C(N)N=C(N)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, but is still available in some countries. Option B: Acute exposure to high concentrations of it can cause pulmonary edema, coughing, and shortness of breath in humans. Option C: It has low inhalation hazard and no apparent skin manifestations or other toxicity in humans. Option D: It shows a moderate level of toxicity to fish, daphnia and earthworms but is relatively non-toxic to honey bees, birds and algae. " A 3961 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has a low rate of transient serum aminotransferase elevations and has been linked to rare instances of acute liver injury. Option B: It has a moderate rate of serum aminotransferase elevations during therapy and rare instances of clinically apparent acute liver injury. Option C: It is associated with a moderate rate of serum aminotransferase elevations and rare instances of clinically apparent acute liver injury. Option D: It has been linked to a low rate of transient serum aminotransferase elevations during therapy and to rare instances of clinically apparent liver injury. " A 443067 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC(=O)[C@H](C)OC(=O)NC1=CC=CC=C1 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. Option B: It has relatively low mammalian oral and dermal toxicity. Option C: It has low mammalian oral and dermal toxicity. Option D: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. " B 6544 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=O)CC(C1)(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause headaches, malaise, confusion, and nervous irritation when inhaled. Option B: It causes central nervous system effects when inhaled at high concentrations. Option C: It can cause sensitization and asthma in humans when inhaled at high concentrations. Option D: It may cause neurotoxicity, especially in patients with renal impairment. " B 533 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [SeH2] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has potential hepatotoxic effects in humans. Option B: It contributes to hepatotoxicity. Option C: It is associated with a risk of hepatotoxicity. Option D: It can cause hepatotoxicity after an overdose. " B 54671203 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of clinically apparent cholestatic liver injury. Option B: It has been linked to rare instances of acute cholestatic liver injury. Option C: It has been linked to rare instances of clinically apparent acute cholestatic liver injury. Option D: It is a rare cause of clinically apparent acute cholestatic liver injury. " B 7361 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=COC(=C1)CO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by inhalation, skin absorption, and ingestion. Option B: It is toxic by ingestion, inhalation, and skin absorption. Option C: It is toxic by inhalation, ingestion, and skin absorption. Option D: It is toxic by ingestion, skin contact, and inhalation. " D 15415 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)CC(C(=O)OCC)SP(=O)(OC)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is more toxic than malathion. Option B: It is more toxic than diazinon. Option C: It is highly toxic. Option D: It is extremely toxic to birds. " A 3118 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)SCCSCC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by ingestion, inhalation, or skin absorption. Option B: It is toxic by inhalation, skin absorption, and ingestion. Option C: It is toxic by inhalation, skin absorption, and/or ingestion. Option D: It is toxic by inhalation, skin absorption, or ingestion. " C 17592 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC(=C1C)C)OC(=O)NC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low mammalian toxicity, but there is some concern regarding its potential for bioaccumulation. Option B: It has relatively low mammalian oral and dermal toxicity. Option C: It has low mammalian oral and dermal toxicity. Option D: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. " B 4917 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is a rare cause of clinically apparent acute cholestatic liver injury. Option B: It has been linked to rare instances of clinically apparent acute cholestatic liver injury. Option C: It can cause clinically apparent acute and chronic cholestatic liver injury. Option D: It has been linked to rare instances of clinically apparent cholestatic liver injury. " C 2801 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with minor transient serum enzyme elevations and has been linked to rare cases of clinically apparent acute liver injury. Option B: It can cause mild and transient serum enzyme elevations and is a rare cause of clinically apparent acute liver injury. Option C: It is associated with a high rate of serum enzyme elevations and rare instances of clinically apparent acute liver injury. Option D: It has been associated with serum enzyme elevations during therapy and with rare instances of clinically apparent acute liver injury. " B 36294 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)N)O)O)O[C@@H]3[C@@H](C[C@@H]([C@H](O3)CN)O)N)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits toxicity by ingestion, inhalation, and skin absorption. Option B: It exhibits nephrotoxicity and ototoxicity. Option C: It may be toxic by ingestion, inhalation, and skin absorption. Option D: It may be slightly toxic by ingestion, inhalation, and skin absorption. " B 445354 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/CO)/C)/C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: Acute exposure to high levels of it may cause severe dermatitis, eye irritation and tearing, asthma, gastritis, renal failure, vertigo, tremors, convulsions, and coma in humans. Option B: It can cause neurotoxicity in humans, including numbness, cyanosis, hyperesthesia, and muscle spasms. Option C: It can lead to liver injury, jaundice, enlargement of the liver and spleen, portal hypertension, and cirrhosis. Option D: It affects the liver, including hepatitis and jaundice, and central nervous system effects, such as depression and irritability. " C 3690 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(P(=O)(OC1)NCCCl)CCCl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause minor transient serum enzyme elevations and has been linked to cases of acute liver injury including cholestatic hepatitis and acute veno-occlusive disease. Option B: It can cause mild and transient serum aminotransferase elevations and rare instances of acute liver injury, which can be severe and prolonged and lead to significant hepatic fibrosis. Option C: Long-term therapy with this molecule is associated with the development of fatty liver, steatohepatitis, cirrhosis, and rare instances of clinically apparent acute liver injury. Option D: It has been linked to cases of acute liver injury, including acute cholestatic hepatitis and veno-occlusive disease. " D 9864 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(#N)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause ulceration of the gastrointestinal and genitourinary tracts, along with electrolyte and renal function disturbance. Option B: It can cause chronic rhinitis with perforation of the nasal septum. Option C: It can cause conjunctivitis, rhinitis, rhinoconjunctivitis, bronchitis, and irritation of the skin and mucous membranes of the respiratory tract. Option D: It can cause minor transient serum enzyme elevations and has been linked to cases of acute liver injury including cholestatic hepatitis and acute veno-occlusive disease. " B 8607 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=O)N(C2=O)SC(Cl)(Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low acute toxicity. Option B: It has low acute and chronic toxicity. Option C: It has low acute animal toxicity. Option D: It has low acute toxicity to mammals. " D 702 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of clinically apparent acute drug induced liver injury. Option B: It can be lethal when blood alcohol level reaches 0.4%. Option C: It has been linked to several instances of clinically apparent drug induced liver injury. Option D: It is a known cause of clinically apparent acute drug induced liver injury. " B 71496458 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with a moderate rate of serum aminotransferase elevations during therapy and rare instances of clinically apparent acute liver injury. Option B: It is associated with a moderate rate of serum aminotransferase elevations during therapy and rare instances of acute liver injury. Option C: It has a moderate rate of serum aminotransferase elevations during therapy and rare instances of clinically apparent acute liver injury. Option D: It is associated with a moderate rate of serum aminotransferase elevations and rare instances of clinically apparent acute liver injury. " A 6354 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CO1 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause irritation of the eyes, skin, nose, throat, and lungs, and damage to the brain and nervous system. Option B: It can cause drowsiness, dizziness, headaches, eye, skin, and respiratory tract irritation, and unconsciousness at high levels when inhaled by humans. Option C: It can irritate the eyes, nose, and throat and may cause headaches, dizziness, and nausea in humans. Option D: It can cause vertigo, drowsiness, headache, anorexia, and irritation of the eyes, nose, throat, and lungs. " A 3030 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=C(C=CC(=C1C(=O)O)Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause illness by inhalation, skin absorption, and/or ingestion. Option B: It can cause illness by inhalation, skin absorption and/or ingestion. Option C: It may be toxic by ingestion, inhalation, or skin absorption. Option D: It may be slightly toxic by ingestion, inhalation, and skin absorption. " B 7047 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC=N2 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can irritate the eyes, nose, and throat and may cause headaches, dizziness, and nausea in humans. Option B: It can cause drowsiness, dizziness, headaches, eye, skin, and respiratory tract irritation, and unconsciousness at high levels when inhaled by humans. Option C: It can cause vertigo, drowsiness, headache, anorexia, and irritation of the eyes, nose, throat, and lungs. Option D: It can cause blurred vision, headache, dizziness, and nausea in humans when exposed to it by inhalation or ingestion. " A 54454 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C)(C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause mild-to-moderate serum aminotransferase elevations and high doses and certain formulations have been linked to clinically apparent, acute liver injury. Option B: It can cause transient and usually asymptomatic elevations in serum aminotransferase levels and rare instances of clinically apparent acute liver injury. Option C: It is frequently associated with mild serum aminotransferase elevations and, in rare instances, can lead to serious clinically apparent, acute or chronic liver disease. Option D: It can cause mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. " D 5253 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause clinically apparent liver injury. Option B: It can cause clinically apparent acute liver injury. Option C: It can cause clinically apparent, acute liver injury. Option D: It can cause rare instances of acute, clinically apparent liver injury. " A 7847 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by inhalation, skin absorption, or ingestion. Option B: It is toxic to humans following inhalation, oral or dermal exposures. Option C: It is extremely toxic from acute (short-term) inhalation, oral, and dermal exposures. Option D: It is toxic by inhalation, skin absorption, and ingestion. " B 5853 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=O)(C(C(Cl)(Cl)Cl)O)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is highly toxic by inhalation and ingestion. Option B: It is toxic to target insects through direct applications and by ingestion. Option C: It may be toxic by inhalation or ingestion. Option D: It is toxic by ingestion and inhalation. " B 5569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN(CCC)C1=C(C=C(C=C1[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has an acute toxicity (LD50) of 200 to 300 mg/kg in rodents. Option B: It has low to moderate acute toxicity, with kidney and liver effects as the main hazard concerns. Option C: It can cause skeletal abnormalities and depressed fetal weight in rodents. Option D: It has an incidence of severe liver damage of approximately 1 in 250,000 to 300,000 patient-years. " C 3339 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to cases of acute liver injury, including acute cholestatic hepatitis and veno-occlusive disease. Option B: It can cause mild and transient serum aminotransferase elevations and rare instances of acute liver injury, which can be severe and prolonged and lead to significant hepatic fibrosis. Option C: Long-term therapy with this molecule is associated with the development of fatty liver, steatohepatitis, cirrhosis, and rare instances of clinically apparent acute liver injury. Option D: It can cause minor transient serum enzyme elevations and has been linked to cases of acute liver injury including cholestatic hepatitis and acute veno-occlusive disease. " B 27854 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Mn+2] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It affects the liver, including hepatitis and jaundice, and central nervous system effects, such as depression and irritability. Option B: It can cause neurotoxicity in humans, including numbness, cyanosis, hyperesthesia, and muscle spasms. Option C: It affects the human central nervous system (CNS), with symptoms such as dizziness, headaches, confusion, euphoria, facial numbness, and weakness. Option D: It can cause manganism, a neurodegenerative disorder that causes dopaminergic neuronal death and parkinsonian-like symptoms. " D 4173 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NC=C(N1CCO)[N+](=O)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is a well established cause of acute, clinically apparent liver injury. Option B: It can be associated with rare instances of clinically apparent acute liver injury. Option C: It has been associated with rare instances of acute, clinically apparent liver injury. Option D: It can cause rare instances of acute, clinically apparent liver injury. " D 7854 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC#N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by inhalation, skin absorption, or ingestion. Option B: It is toxic by inhalation, ingestion, and skin absorption. Option C: It is toxic by inhalation, skin absorption, and ingestion. Option D: It is toxic by ingestion, inhalation, and skin absorption. " C 2708 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is less toxic than most other nitrogen mustards, but it is a known carcinogen. Option B: It is less toxic than phenytoin. Option C: It is less potent but less toxic than the molecule produced in the 1950s. Option D: It is much less toxic than chromium (VI). " A 13387 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CCCC1=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is slightly toxic. Option B: It may be slightly toxic by ingestion. Option C: It is a reproductive toxicant. Option D: It is highly toxic. " C 49806720 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC1=CC2=C(C=C1N3CCC(CC3)N4CCOCC4)C(C5=C(C2=O)C6=C(N5)C=C(C=C6)C#N)(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with a low rate of transient serum aminotransferase elevations during therapy and rare cases of clinically apparent acute liver injury. Option B: It is associated with a moderate rate of serum aminotransferase elevations during therapy and rare instances of clinically apparent acute liver injury. Option C: It has a moderate rate of serum aminotransferase elevations during therapy and rare instances of clinically apparent acute liver injury. Option D: It is associated with a moderate rate of transient elevations in serum aminotransferase levels during therapy and with rare instances of clinically apparent acute liver injury. " D 441071 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN2CC3=CCO[C@H]4CC(=O)N5[C@H]6[C@H]4[C@H]3C[C@H]2[C@@]61C7=CC=CC=C75 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause dermatitis and conjunctivitis in humans when dermally exposed. Option B: It causes histopathological and biochemical changes, including erosion of gastric mucosa and hepatic necrosis. Option C: It can cause conjunctivitis, rhinitis, rhinoconjunctivitis, bronchitis, and irritation of the skin and mucous membranes of the respiratory tract. Option D: It causes muscular convulsions and eventually death through asphyxia or sheer exhaustion. " D 10800 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC(=C1O)[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause sensitization and asthma in humans when inhaled at high concentrations. Option B: It may cause neurotoxicity, especially in patients with renal impairment. Option C: It has been reported to cause clinically apparent fatal, acute liver injury. Option D: It can cause bilateral cataracts and blindness when chronically ingested. " D 7570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CC2=CC=C(C=C2)N=C=O)N=C=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may cause neurotoxicity, especially in patients with renal impairment. Option B: It can cause sensitization and asthma in humans when inhaled at high concentrations. Option C: It has the potential for serious morbidity and mortality with over dosage. Option D: It can cause serious toxicity and possibly death. " B 26623 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Hg+2] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: The margin between toxic and therapeutic doses is small. Option B: It is toxic in large doses. Option C: It produces birth defects and embryotoxicity at high doses. Option D: It can produce toxicity in high enough doses. " D 444 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: Therapy with this molecule is associated with transient elevations in serum aminotransferase levels and rare instances of clinically apparent acute liver injury, which can be severe and sometimes fatal. Option B: It can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. Option C: It can be associated with transient, usually asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. Option D: It can cause transient and usually asymptomatic elevations in serum aminotransferase levels and is a rare cause of clinically apparent, acute liver injury. " C 169132 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(CC(CC(C1)(C)CN=C=O)N=C=O)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by inhalation and skin absorption. Option B: It is toxic by ingestion, inhalation, and skin absorption. Option C: It is toxic by inhalation, ingestion, or skin absorption. Option D: It is toxic by inhalation and by skin absorption. " A 4735 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may cause severe damage to the skin, eyes, respiratory tract, and mucous membranes and cause depression of the central nervous system in humans. Option B: It can cause eye and skin irritation and toxic effects on the liver, kidneys, and central and peripheral nervous systems. Option C: It can cause diabetes mellitus, central nervous system damage, and other toxic effects. Option D: It is a central nervous system toxicant and has been shown to damage the lungs and kidneys in animal testing. " C 11715 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)CBr Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity. Option B: It is considered obsolete (due to its toxicity) and is no longer in use for riot control purposes. Option C: It has low inhalation hazard and no apparent skin manifestations or other toxicity in humans. Option D: It can cause drug overdose and toxicity from accidental ingestion due to its profound sedation effects. " B 6058 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CS)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been associated with serum enzyme elevations when given intravenously in high doses, but it has not been shown to cause clinically apparent acute liver injury. Option B: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent acute liver injury with jaundice. Option C: It has been reported to cause serum enzyme elevations during therapy but has not been implicated in instances of clinically apparent acute liver injury. Option D: It has a modest rate of serum enzyme elevations during therapy, but has not been convincingly linked to instances of clinically apparent acute liver injury. " A 7775 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC(=O)OCC(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by inhalation, ingestion, or skin absorption. Option B: It may be toxic by ingestion, inhalation, or skin absorption. Option C: It is toxic by ingestion, inhalation, or skin absorption. Option D: It is toxic by ingestion, inhalation, and skin absorption. " B 3562 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(F)(F)F)(Cl)Br Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of clinically apparent, idiosyncratic liver injury. Option B: It has been linked to rare cases of idiosyncratic, clinically apparent liver injury. Option C: It has been associated with idiosyncratic, clinically apparent acute liver injury. Option D: It has been linked to many cases of idiosyncratic acute liver injury that are frequently severe. " D 712 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause neurotoxicity in humans, including numbness, cyanosis, hyperesthesia, and muscle spasms. Option B: It can cause effects to the lungs, liver, spleen, and thyroid in animals chronically exposed to it via inhalation. Option C: It can be associated with hyperthermia, rhabdomyolysis, shock and acute liver injury which can be severe and even fatal. Option D: Acute and chronic inhalation exposure to it in humans can result in respiratory symptoms, and eye, nose, and throat irritation. " D 23969 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [AsH3] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is a clear, nontoxic liquid essential for life and the most widely used solvent. Option B: It is a colorless, toxic, and highly reactive gas. Option C: It is extremely toxic and among the most poisonous chemicals commonly used for pest control. Option D: It is a colorless, flammable, and highly toxic gas. " D 2764 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of acute liver injury that can be severe and even fatal. Option B: It has been linked to rare but convincing instances of liver injury that can be severe and even fatal. Option C: It has been linked to rare instances of acute liver injury that can be severe and result in death. Option D: It has been clearly linked to instances of acute and chronic liver injury that can be severe and even fatal. " B 3001055 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN/C(=C\\[N+](=O)[O-])/NCCSCC1=CC=C(O1)CN(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is linked to rare instances of clinically apparent acute liver injury. Option B: It can be associated with rare instances of clinically apparent acute liver injury. Option C: It has been linked to rare instances of clinically apparent acute liver injury. Option D: It has rare instances of clinically apparent acute liver injury. " C 3365 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to several instances of clinically apparent drug induced liver injury. Option B: It has been linked to rare instances of clinically apparent drug induced liver disease. Option C: It has been linked to rare instances of clinically apparent acute drug induced liver injury. Option D: It is a known cause of clinically apparent acute drug induced liver injury. " D 23925 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Fe] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It causes serious toxicities, one component of which is acute liver damage. Option B: It has been associated with serum enzyme elevations during therapy and with rare instances of clinically apparent acute liver injury. Option C: It can cause mild and transient serum enzyme elevations and is a rare cause of clinically apparent acute liver injury. Option D: It can cause serum enzyme elevations during therapy and rare instances of clinically apparent acute liver injury. " A 47326 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C(C1(C)C)C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can harm sensitive individuals, but in general, it is harmless to human beings. Option B: It is generally harmless but can harm sensitive individuals. Option C: It can harm sensitive individuals. Option D: It is generally harmless to human beings but can harm sensitive individuals. " C 7577 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1CC2=CC=C(C=C2)N)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It causes liver damage in humans and animals. Option B: Chronic exposure can result in liver damage. Option C: It may cause liver damage in humans. Option D: It causes serious toxicities, one component of which is acute liver damage. " A 6360 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can asphyxiate by the displacement of air. Option B: It is very toxic by inhalation and ingestion. Option C: It is not toxic but is a simple asphyxiate by the displacement of oxygen in the air. Option D: It is toxic and its use is being phased out in Brazil. " A 32490 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCOC(=O)NCCCN(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has relatively low mammalian oral and dermal toxicity. Option B: It has low mammalian oral and dermal toxicity. Option C: It has relatively low mammalian oral and dermal toxicity and broad control spectrum, making it widely used in lawn and garden settings. Option D: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. " A 24404 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: P Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: Acute inhalation exposure to it may cause irritation of the eyes, cough, wheezing, asthmatic symptoms, pulmonary edema, pneumonia, dizziness, weakness, headache, and chest pains. Option B: Acute exposure to high levels of it may cause severe dermatitis, eye irritation and tearing, asthma, gastritis, renal failure, vertigo, tremors, convulsions, and coma in humans. Option C: It may cause headaches, dizziness, fatigue, drowsiness, burning substernal pain, nausea, vomiting, cough, labored breathing, chest tightness, pulmonary irritation, pulmonary edema, and tremors in humans. Option D: It can result in weakness, headache, dizziness, nausea, abdominal pain, myotonia, hypotension, renal and hepatic injury, and delayed neuropathy. " C 5161 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)C(=O)OC2=CC=CC=C2C(=O)O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with transient and usually mild elevations in serum aminotransferase levels. Option B: It has been associated with mild, transient serum aminotransferase elevations. Option C: It often causes mild to moderate elevations in serum aminotransferase levels. Option D: It causes moderate serum aminotransferase elevations. " D 31736 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)COC(=O)C2=CC=CC=C2C(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low acute toxicity to mammals. Option B: It has low acute toxicity. Option C: It has low acute animal toxicity. Option D: It has low acute and chronic toxicity. " C 5388962 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of acute liver injury. Option B: It can be associated with rare instances of clinically apparent acute liver injury. Option C: It is linked to rare instances of clinically apparent acute liver injury. Option D: It has been linked to rare instances of clinically apparent acute liver injury. " A 4911 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been associated with frequent serum aminotransferase elevations during therapy and with rare, but sometimes severe and even fatal instances of clinically apparent liver injury. Option B: It has been associated with minor serum aminotransferase elevations and very rarely with hypersensitivity reactions which, even more rarely, can be accompanied by acute liver injury. Option C: It is associated with transient and usually mild elevations in serum aminotransferase levels during therapy, but has not been linked to cases of clinically apparent acute liver injury. Option D: It can be associated with transient, usually asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. " B 31289 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCC=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause symptoms of acute inhalation exposure such as dizziness, nausea, vomiting, diarrhea, loss of consciousness, and decreased blood pressure. Option B: It can cause severe liver damage and some kidney damage from acute inhalation exposure. Option C: It can lead to renal damage, chronic kidney disease, and cardiovascular disease. Option D: It can cause chronic exposure of uremic toxins, leading to conditions such as renal damage, chronic kidney disease, and cardiovascular disease. " C 14915 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=[Cr](=O)=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is more toxic than other oxidation states of the chromium atom due to its greater ability to enter cells and higher redox potential. Option B: It has a greater ability to enter cells and higher redox potential. Option C: It has low toxicity, offering a safer alternative to other drugs used for insomnia. Option D: It is more toxic due to its greater ability to enter cells and higher redox potential. " B 52999 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=NC(=NC(=N1)OC)NC(=O)NS(=O)(=O)C2=CC=CC=C2C(=O)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause clinically apparent liver injury that can be severe and even fatal. Option B: It causes severe eye irritation and moderate skin irritation. Option C: It has been linked to rare instances of acute liver injury that can be severe and even fatal. Option D: It is a moderate eye irritant. " D 193653 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([C@@H](C(=O)O)N)SCC(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause clinically apparent liver injury that can be severe and even fatal. Option B: It can cause severe and even fatal liver injury. Option C: It can cause serious and fatal paradoxical effects. Option D: It can cause severe and sometimes fatal acute liver injury. " C 6276 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic to fish. Option B: It is extremely toxic to birds. Option C: It is moderately toxic to fish. Option D: It is moderately toxic by ingestion. " D 6344 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause clinically apparent, acute liver injury. Option B: It can cause decreased visual, auditory, and motor functions. Option C: It has been reported to cause clinically apparent fatal, acute liver injury. Option D: It can cause corneal injury, liver, and neurological effects. " B 24066 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C[C@@H](O[C@@H]1CO)N2C=CC(=NC2=O)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has rarely been implicated in causing clinically apparent acute liver injury. Option B: It has been linked to rare instances of clinically apparent acute liver injury. Option C: It can cause axonal degeneration resulting in peripheral neuropathy. Option D: It has been linked to rare instances of clinically apparent acute liver injury with jaundice. " C 60613 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CN(C(=O)N=C1N)C[C@@H](CO)OCP(=O)(O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It often causes mild to moderate elevations in serum aminotransferase levels. Option B: It is associated with mild-to-moderate serum aminotransferase elevations. Option C: It has been associated with mild, transient serum aminotransferase elevations. Option D: It is associated with transient and usually mild elevations in serum aminotransferase levels. " B 644019 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC1=CC(=C(C(=C1)O)[C@@H]2C=C(CC[C@H]2C(=C)C)C)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with frequent serum enzyme elevations but not clinically apparent liver injury with jaundice. Option B: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option C: It has not been linked to significant serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. Option D: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent acute liver injury with jaundice. " A 177 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: Symptoms of chronic intoxication resemble those of alcoholism. Option B: It is relatively nontoxic but alters the intermediary metabolism of alcohol. Option C: It is generally well tolerated and has not been linked to serum enzyme elevations or clinically apparent liver injury. Option D: It is relatively nontoxic and noncombustible. " A 6129 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC(=O)OC1=CC=CC2=CC=CC=C21 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. Option B: It has low mammalian toxicity, but there is some concern regarding its potential for bioaccumulation. Option C: It has relatively low mammalian oral and dermal toxicity. Option D: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. " C 7095 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C2=CC=CC=C2 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause tumors of the brain, spinal cord, nerves, stomach, pancreas, and kidneys. Option B: It can cause eye and skin irritation and toxic effects on the liver, kidneys, and central and peripheral nervous systems. Option C: It can cause irritation of the eyes, skin, nose, throat, and lungs, and damage to the brain and nervous system. Option D: It can depress the central nervous system (CNS), irritate the lungs and skin, and affect the kidneys. " B 54680690 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)[C@H]1[C@@H]2C[C@@H]3[C@@H](C4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)Cl)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can lead to acute psychosis, aggressive and violent behaviors, and overdoses can cause status epilepticus, hyperthermia, rhabdomyolysis and subsequent renal, respiratory and hepatic failure. Option B: It can cause hypertensive crisis when ingested with tyramine-rich diet in conjunction with monoamine oxidase inhibitors (MAOIs). Option C: It has been associated with rare instances of idiosyncratic acute liver injury; in addition, prolonged high dose therapy can cause the “infusion syndrome” which is marked by bradyarrhythmias, metabolic acidosis, rhabdomyolysis, hyperlipidemia and an enlarged or fatty liver. Option D: It is likely to cause injury similar to that described for tetracycline, oxytetracycline, and doxycycline. " D 39941 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C1=CC2=C(C=C1)OC(=N2)C3=CC=C(C=C3)Cl)C(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute cholestatic liver injury. Option B: It can cause mild and transient serum enzyme elevations and is a rare cause of clinically apparent acute cholestatic liver injury. Option C: It can cause mild and transient serum enzyme elevations and is a rare cause of clinically apparent acute and chronic cholestatic liver injury. Option D: It was associated with fatal cholestatic jaundice among other serious adverse reactions. " D 4409 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)CCC1=CC2=C(C=C1)C=C(C=C2)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of idiosyncratic drug induced liver disease. Option B: It can cause acute idiosyncratic drug induced liver disease. Option C: It has been linked to rare instances of idiosyncratic drug-induced liver disease. Option D: It has been linked to rare instances of clinically apparent, idiosyncratic drug induced liver disease. " D 4932 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute cholestatic liver injury. Option B: It can cause mild and transient serum enzyme elevations and is a rare cause of clinically apparent acute cholestatic liver injury. Option C: It can rarely cause a self-limited, acute cholestatic liver injury. Option D: It can cause rare instances of clinically apparent, acute cholestatic liver injury. " C 3031 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C(=C1)Cl)C#N)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause illness by inhalation, skin absorption, and/or ingestion. Option B: It is toxic by inhalation, skin absorption, or ingestion. Option C: It can cause illness by inhalation, skin absorption and/or ingestion. Option D: It may cause illness by inhalation, skin absorption, and/or ingestion. " C 3080 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(CS)S)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low inhalation hazard and no apparent skin manifestations or other toxicity in humans. Option B: It can cause drug overdose and toxicity from accidental ingestion due to its profound sedation effects. Option C: It has toxic potential, and its use may be followed by a variety of adverse effects. Option D: Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity. " C 446220 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1[C@H]2CC[C@@H]1[C@H]([C@H](C2)OC(=O)C3=CC=CC=C3)C(=O)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can lead to liver injury, jaundice, enlargement of the liver and spleen, portal hypertension, and cirrhosis. Option B: It can cause neurotoxicity in humans, including numbness, cyanosis, hyperesthesia, and muscle spasms. Option C: It affects the liver, including hepatitis and jaundice, and central nervous system effects, such as depression and irritability. Option D: It can be associated with hyperthermia, rhabdomyolysis, shock and acute liver injury which can be severe and even fatal. " D 1978 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC(=O)NC1=CC(=C(C=C1)OCC(CNC(C)C)O)C(=O)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to several instances of clinically apparent drug induced liver injury. Option B: It is a known cause of clinically apparent acute drug induced liver injury. Option C: It has very rarely been linked to clinically apparent acute drug induced liver injury. Option D: It has been linked to rare instances of clinically apparent acute drug induced liver injury. " A 5324346 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCCC/C(=N\\OCCN)/C1=CC=C(C=C1)C(F)(F)F Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause transient and usually asymptomatic elevations in serum aminotransferase levels and is a rare cause of clinically apparent, acute liver injury. Option B: It is associated with transient elevations in serum aminotransferase levels and rare instances of clinically apparent acute liver injury. Option C: It can be associated with transient, usually asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. Option D: It can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. " D 1145 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+](C)(C)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been associated with rare instances of idiosyncratic acute liver injury; in addition, prolonged high dose therapy can cause the “infusion syndrome” which is marked by bradyarrhythmias, metabolic acidosis, rhabdomyolysis, hyperlipidemia and an enlarged or fatty liver. Option B: It is a uremic toxin, an osmolyte and an atherotoxin (causing atherosclerotic plaques). Option C: It can cause inflammation and irritation to the urinary bladder and urethra, and similar changes have recently been described in the biliary tract, resulting in an acute or chronic cholestatic liver injury that can resemble sclerosing cholangitis. Option D: It can lead to acute psychosis, aggressive and violent behaviors, and overdoses can cause status epilepticus, hyperthermia, rhabdomyolysis and subsequent renal, respiratory and hepatic failure. " B 17040 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)OC(=O)NC)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. Option B: It has low mammalian toxicity, but there is some concern regarding its potential for bioaccumulation. Option C: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. Option D: It has relatively low mammalian oral and dermal toxicity. " D 54687 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@H](C)C(=O)O[C@H]1C[C@@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@H](C[C@H](CC(=O)O)O)O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has mild, asymptomatic and self-limited serum aminotransferase elevations during therapy and rarely with clinically apparent acute liver injury. Option B: It can cause mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. Option C: It is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, but has had limited use and has yet to be linked with clinically apparent acute liver injury. Option D: It is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. " D 2165 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CC1=C(C=CC(=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to severe cases of acute hepatitis which can be fatal. Option B: It has been linked to rare cases of drug-induced liver injury, some of which have been fatal. Option C: It has been linked to several cases of clinically apparent drug induced liver disease, some of which have been severe and even fatal. Option D: It has been associated with occasional cases of severe and distinctive acute hepatic failure. " A 6811 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=O)OC2=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause minor transient serum enzyme elevations and has been linked to cases of acute liver injury including cholestatic hepatitis and acute veno-occlusive disease. Option B: Acute exposure to high levels of it may cause severe dermatitis, eye irritation and tearing, asthma, gastritis, renal failure, vertigo, tremors, convulsions, and coma in humans. Option C: It has been linked to cases of acute liver injury, including acute cholestatic hepatitis and veno-occlusive disease. Option D: It can cause conjunctivitis, rhinitis, rhinoconjunctivitis, bronchitis, and irritation of the skin and mucous membranes of the respiratory tract. " D 5284583 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@@H](C(=O)N)N1CCCC1=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is commonly associated with transient elevations in serum aminotransferase levels during treatment, but with only rare instances of clinically apparent acute liver injury. Option B: It is associated with transient elevations in serum aminotransferase levels during therapy and has been reported to cause clinically apparent acute liver injury and rare instances of death. Option C: It can cause rare instances of serum aminotransferase and alkaline phosphatase elevations during treatment and rare cases of clinically apparent drug-induced liver disease. Option D: It can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. " C 5360835 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Ga] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by ingestion and inhalation. Option B: It may be toxic by ingestion and inhalation. Option C: It is toxic by inhalation and ingestion. Option D: It may be toxic by ingestion. " D 69698 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C=C(C=CC1=O)C(=O)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of clinically apparent acute drug induced liver injury. Option B: It has been linked to several instances of clinically apparent drug induced liver injury. Option C: It has toxic properties and suggests that it is an uremic toxin. Option D: It is a uremic toxin and has been involved in the progression of renal failure. " C 11761 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=CC=C1)[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It emits toxic oxides of nitrogen when heated to decomposition. Option B: It emits toxic oxides of nitrogen fumes when heated to decomposition. Option C: It may emit highly toxic nitrogen oxide fumes when heated to decomposition. Option D: It produces toxic oxides of nitrogen during combustion. " D 5971 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCN=C=S Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by inhalation, ingestion, and skin absorption. Option B: It is toxic by ingestion, inhalation, and skin absorption. Option C: It is toxic by ingestion and skin absorption. Option D: It is poisonous by ingestion and skin absorption. " D 7964 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It affects the liver, including hepatitis and jaundice, and central nervous system effects, such as depression and irritability. Option B: It can lead to liver injury, jaundice, enlargement of the liver and spleen, portal hypertension, and cirrhosis. Option C: Acute exposure to high levels of it may cause severe dermatitis, eye irritation and tearing, asthma, gastritis, renal failure, vertigo, tremors, convulsions, and coma in humans. Option D: It can cause neurotoxicity in humans, including numbness, cyanosis, hyperesthesia, and muscle spasms. " D 10484 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)S Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may be toxic by ingestion, inhalation, and skin absorption. Option B: It is toxic by ingestion, inhalation, and skin absorption. Option C: It is toxic by inhalation, skin absorption, and ingestion. Option D: It is toxic by inhalation, skin absorption, or ingestion. " A 7485 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by ingestion, inhalation, or skin absorption. Option B: It may be toxic by ingestion, inhalation, or skin absorption. Option C: It is toxic by inhalation, ingestion, or skin absorption. Option D: It is toxic by ingestion, inhalation, and skin absorption. " B 8071 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCOC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is highly toxic by inhalation and ingestion. Option B: It is toxic by ingestion and inhalation. Option C: It is mildly toxic by inhalation. Option D: It is mildly toxic by ingestion and inhalation. " D 5329102 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\\2/C3=C(C=CC(=C3)F)NC2=O)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. Option B: It has transient elevations in serum aminotransferase and bilirubin levels and rare instances of clinically apparent acute liver injury. Option C: It is associated with transient elevations in serum aminotransferase and bilirubin levels and rare instances of clinically apparent acute liver injury. Option D: It can cause transient and usually asymptomatic elevations in serum aminotransferase levels and rare instances of clinically apparent acute liver injury. " C 289 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been reported to cause clinically apparent fatal, acute liver injury. Option B: It increases the incidence of liver tumors in mice orally exposed to it. Option C: It causes hepatocellular carcinomas (liver tumors) in mice following oral exposure. Option D: It can cause tumors in the glandular stomach in orally exposed rats. " D 30773 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC1=NC(=NC(=N1)Cl)NC(C)(C)C#N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low to moderate acute toxicity, with kidney and liver effects as the main hazard concerns. Option B: It is toxic to both prokaryotic and eukaryotic cells, resulting in significant cell death at appropriate doses. Option C: It is classified as a Restricted Use Pesticide (RUP) because of its teratogenicity and because it has been found in groundwater. Option D: It has low inhalation hazard and no apparent skin manifestations or other toxicity in humans. " C 3308 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC1=C2C(=CC=C1)C3=C(N2)C(OCC3)(CC)CC(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare cases of clinically apparent drug induced liver disease. Option B: It is linked to rare cases of clinically apparent drug-induced liver disease. Option C: It has been linked to several instances of clinically apparent drug induced liver injury. Option D: It has been linked to rare instances of clinically apparent drug induced liver disease. " D 996 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is highly toxic to aquatic life, particularly fish. Option B: It is highly toxic to mammals and insects. Option C: It is quite toxic to humans via oral exposure. Option D: It is selectively more toxic to insects than mammals. " C 4659569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)C(=O)C2=CC(=C(C(=C2)O)O)[N+](=O)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has potential hepatotoxic effects in humans. Option B: It is associated with a risk of hepatotoxicity. Option C: It has a lower risk of hepatotoxicity. Option D: It contributes to hepatotoxicity. " B 7150 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)C1=CC=CC=C1 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is moderately toxic by ingestion. Option B: It is highly toxic by inhalation and ingestion. Option C: It is very toxic by inhalation and ingestion. Option D: It may be slightly toxic by ingestion. " D 16248 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC(=C1SC)C)OC(=O)NC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has relatively low mammalian oral and dermal toxicity. Option B: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. Option C: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. Option D: It has low mammalian toxicity, but there is some concern regarding its potential for bioaccumulation. " A 93542 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC(=O)CSC1=C(C=C(C(=C1)N=C2N3CCCCN3C(=O)S2)F)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has relatively low mammalian oral and dermal toxicity. Option B: It has acute dermal toxicity. Option C: It has low mammalian oral and dermal toxicity. Option D: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. " B 213021 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=NC#N)N(C)CC1=CN=C(C=C1)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is highly toxic to mammals and insects. Option B: It is selectively more toxic to insects than mammals. Option C: It is highly toxic to aquatic life, particularly fish. Option D: It is moderately toxic to humans, mammals, birds and most aquatic organisms. " B 6497 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COS(=O)(=O)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause irritation of the eyes, skin, nose, throat, and lungs, and damage to the brain and nervous system. Option B: It may cause severe damage to the skin, eyes, respiratory tract, and mucous membranes and cause depression of the central nervous system in humans. Option C: It may cause severe inflammation and necrosis of the eyes, mouth, and respiratory tract. Option D: It can cause eye and skin irritation and toxic effects on the liver, kidneys, and central and peripheral nervous systems. " C 23978 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Cu] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare but convincing instances of liver injury that can be severe and even fatal. Option B: It can be poisonous or even fatal to organisms in sufficient amounts. Option C: It is associated with rare instances of clinically apparent, acute liver injury that can be severe and even fatal. Option D: It has been linked to rare instances of acute liver injury that can be severe and even fatal. " B 213039 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)CN(C[C@H]([C@H](CC1=CC=CC=C1)NC(=O)O[C@H]2CO[C@@H]3[C@H]2CCO3)O)S(=O)(=O)C4=CC=C(C=C4)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause clinically apparent, acute liver injury. Option B: It can cause clinically apparent acute liver injury. Option C: It can cause clinically apparent liver injury. Option D: It has been reported to cause clinically apparent fatal, acute liver injury. " A 3310889 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1NN)[N+](=O)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may emit toxic fumes when heated. Option B: It emits toxic oxides of nitrogen fumes when heated to decomposition. Option C: It emits toxic fumes when heated. Option D: It emits toxic oxides of nitrogen when heated to decomposition. " D 8082 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCNCC1 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may be toxic by ingestion and inhalation. Option B: It is highly toxic by inhalation and ingestion. Option C: It is toxic by inhalation and ingestion. Option D: It is very toxic by inhalation and ingestion. " A 25550 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=C(C(=C1)OC(=O)NC)C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. Option B: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. Option C: It has low mammalian oral and dermal toxicity. Option D: It has relatively low mammalian oral and dermal toxicity. " D 74483 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(C(C(C(F)(F)S(=O)(=O)O)(F)F)(F)F)(F)F)(C(C(C(F)(F)F)(F)F)(F)F)(F)F Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can lead to renal damage, chronic kidney disease, and cardiovascular disease. Option B: It can cause severe liver damage and some kidney damage from acute inhalation exposure. Option C: It can cause chronic exposure of uremic toxins, leading to conditions such as renal damage, chronic kidney disease, and cardiovascular disease. Option D: It affects health parameters and is associated with increased risk of chronic kidney disease. " D 23749 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1N=NC2=CC=C(C=C2)[As](=O)(O)O)[As](=O)(O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is extremely poisonous. Option B: It exhibits poisonous toxicity. Option C: It is a poisonous metalloid. Option D: It is a poisonous gas with a strong repulsive odor. " C 6591 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)Cl)(Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: Animals orally exposed to it observed kidney, liver, and mammary gland tumors. Option B: It increases the incidence of liver tumors in mice orally exposed to it. Option C: It can cause liver and kidney tumors in mice from dermal exposure. Option D: It causes hepatocellular carcinomas (liver tumors) in mice following oral exposure. " B 54886 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC(=O)CCN(C(C)C)SN(C)C(=O)OC1=CC=CC2=C1OC(C2)(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. Option B: It has low mammalian oral and dermal toxicity. Option C: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. Option D: It has relatively low mammalian oral and dermal toxicity. " D 3366 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC(=O)NC(=C1F)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause rare instances of acute, clinically apparent liver injury. Option B: It has been reported to cause clinically apparent fatal, acute liver injury. Option C: It can cause clinically apparent, acute liver injury. Option D: It can cause clinically apparent acute drug-induced liver injury. " D 6511 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[Pb](CC)(CC)CC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by inhalation and skin absorption. Option B: It is toxic by inhalation and by skin absorption. Option C: It is toxic by inhalation, ingestion, and skin absorption. Option D: It is toxic by ingestion, inhalation, and skin absorption. " B 62097 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCNC(=O)OCC#CI Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low mammalian toxicity, but there is some concern regarding its potential for bioaccumulation. Option B: It has relatively low mammalian oral and dermal toxicity. Option C: It has low mammalian oral and dermal toxicity. Option D: It has relatively low mammalian oral and dermal toxicity and broad control spectrum, making it widely used in lawn and garden settings. " B 4495 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2=CC=CC=C2 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause clinically apparent acute liver injury, which can be severe and result in acute liver failure, need for emergency liver transplantation, and death. Option B: It can cause an unusual form of liver injury called pseudocirrhosis caused by shrinkage of tumor metastases in the liver combined with desmoplastic changes and vascular damage, that can be severe, progressive and even fatal. Option C: It can cause liver injury marked by progressive intrahepatic bile duct injury, some of which resulted in liver transplantation or were fatal. Option D: It can cause minor transient serum enzyme elevations and has been linked to cases of acute liver injury including cholestatic hepatitis and acute veno-occlusive disease. " A 8133 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOCCO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can irritate the eyes, nose, and throat and may cause headaches, dizziness, and nausea in humans. Option B: It irritates skin and eyes and may be toxic by ingestion. Option C: It is moderately toxic by ingestion and vapors may irritate skin and eyes. Option D: It is very toxic by inhalation and may irritate the eyes and mucous membranes. " B 33775 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC1=C(C(=O)N(N=C1)C2=CC=CC(=C2)C(F)(F)F)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low toxicity if individuals accidentally eat residues, and very low toxicity if it is inhaled or gets on skin. Option B: It has been reported to cause serum enzyme elevations during therapy but has not been implicated in instances of clinically apparent acute liver injury. Option C: It has not been associated with serum enzyme elevations during treatment and must be a very rare cause of clinically apparent acute liver injury, if it occurs at all. Option D: It has been associated with serum enzyme elevations when given intravenously in high doses, but it has not been shown to cause clinically apparent acute liver injury. " A 9086 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CN)CO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic to fish. Option B: It is highly toxic to aquatic life, particularly fish. Option C: It is moderately toxic to fish. Option D: It is moderately toxic by ingestion. " D 1030 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CO)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent acute liver injury with jaundice. Option B: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option C: It can be toxic in large doses, especially if given over a short period of time. Option D: It has been associated with serum enzyme elevations when given intravenously in high doses, but it has not been shown to cause clinically apparent acute liver injury. " C 7261 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)N)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may be toxic by inhalation or ingestion. Option B: It is toxic by ingestion and inhalation. Option C: It may be toxic by ingestion and inhalation. Option D: It is toxic by inhalation and ingestion. " B 8268 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C(C2=CC=C(C=C2)Cl)(C(Cl)(Cl)Cl)O)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may cause illness by inhalation, skin absorption, and/or ingestion. Option B: It can cause illness by inhalation, skin absorption and/or ingestion. Option C: It is toxic by inhalation, skin absorption, and/or ingestion. Option D: It can cause illness by inhalation, skin absorption, and/or ingestion. " D 167250 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[As](=O)(C)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may be toxic by ingestion, inhalation, or skin absorption. Option B: It is toxic by ingestion, inhalation, or skin absorption. Option C: It is highly toxic by ingestion, inhalation, or skin contact. Option D: It is toxic by inhalation, ingestion, or skin absorption. " C 3289 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCSP(=O)(OCC)SCCC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is very toxic by ingestion, inhalation, and skin absorption. Option B: It is very toxic by inhalation, skin absorption, and ingestion. Option C: It is very toxic by skin absorption and inhalation. Option D: It is very toxic by inhalation and skin absorption. " C 4205 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CCN2C(C1)C3=CC=CC=C3CC4=C2N=CC=C4 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can be associated with clinically apparent acute liver injury. Option B: It has rare instances of clinically apparent acute liver injury. Option C: It is linked to rare instances of clinically apparent acute liver injury. Option D: It has been linked to rare instances of clinically apparent acute liver injury. " A 8141 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It causes abdominal discomfort, nausea, and diarrhea when ingested. Option B: It can cause blurred vision, headache, dizziness, and nausea in humans when exposed to it by inhalation or ingestion. Option C: It can cause drowsiness, dizziness, headaches, eye, skin, and respiratory tract irritation, and unconsciousness at high levels when inhaled by humans. Option D: It can cause symptoms of acute inhalation exposure such as dizziness, nausea, vomiting, diarrhea, loss of consciousness, and decreased blood pressure. " A 1140 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It induces pathological changes in bone (osteolathyrism) and blood vessels (angiolathyrism) of experimental animals without damaging the nervous system. Option B: It affects the liver, including hepatitis and jaundice, and central nervous system effects, such as depression and irritability. Option C: It primarily targets the central nervous system (CNS) for toxicity in both humans and animals. Option D: It can cause a potentially lethal central nervous system condition known as locoism in livestock. " C 442530 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1CC2=C(C=C(C(=C2C(=O)O1)O)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low dermal, oral, and inhalation toxicity. Option B: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. Option C: It has relatively low mammalian oral and dermal toxicity. Option D: It has large species- and sex-specific differences in toxicity. " D 91742 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC1=C(C=C(C=C1)NC(=O)OC(C)C)OCC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. Option B: It has low mammalian oral and dermal toxicity. Option C: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. Option D: It has relatively low mammalian oral and dermal toxicity. " D 446541 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C2COC(=O)C2=C(C(=C1OC)C/C=C(\\C)/CCC(=O)O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It requires therapeutic drug monitoring to minimize toxicity. Option B: It has low toxicity, offering a safer alternative to other drugs used for insomnia. Option C: It has low toxicity to mammals. Option D: It has low acute toxicity to mammals. " A 2160 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause mild and transient serum enzyme elevations and is a rare cause of clinically apparent acute and chronic cholestatic liver injury. Option B: It has mild serum enzyme elevations and has been linked to rare instances of clinically apparent cholestatic liver injury. Option C: It can cause mild and transient serum enzyme elevations and has been linked to rare instances of clinically apparent cholestatic liver injury. Option D: It can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute cholestatic liver injury. " D 992 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=C(C(=C(C(=C1Cl)Cl)Cl)Cl)Cl)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is extremely toxic to humans from acute (short-term) ingestion and inhalation exposure. Option B: It is extremely toxic from acute (short-term) inhalation, oral, and dermal exposures. Option C: It is toxic to humans following inhalation, oral or dermal exposures. Option D: It is toxic by inhalation, skin absorption, or ingestion. " A 2578 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCl)NC(=O)N(CCCl)N=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause minor transient serum enzyme elevations and has been linked to cases of acute liver injury including cholestatic hepatitis and acute veno-occlusive disease. Option B: It has been linked to cases of acute liver injury, including acute cholestatic hepatitis and veno-occlusive disease. Option C: It can cause mild and transient serum aminotransferase elevations and rare instances of acute liver injury, which can be severe and prolonged and lead to significant hepatic fibrosis. Option D: Long-term therapy with this molecule is associated with the development of fatty liver, steatohepatitis, cirrhosis, and rare instances of clinically apparent acute liver injury. " A 440005 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C[C@@H](C(=O)O)N)CN=C(N)N[N+](=O)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low toxicity. Option B: It has minimal toxicity. Option C: It can prevent glutamate toxicity. Option D: It has low toxicity to mammals. " C 935 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Ni] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to an increased risk of lung and nasal cancers. Option B: It is associated with a modest rate of serum enzyme elevations and rare instances of clinically apparent, acute liver injury. Option C: It is associated with high rates of enzyme elevations and acute liver injury due to sinusoidal obstruction syndrome. Option D: It affects health parameters and is associated with increased risk of chronic kidney disease. " A 135398748 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=NC2=C(N1CCC(CO)CO)N=C(NC2=O)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low acute and chronic toxicity. Option B: It has low acute toxicity to mammals. Option C: It has low acute toxicity. Option D: It has low toxicity and good selectivity. " D 443495 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-][As]=O.[Na+] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by inhalation, ingestion, and skin absorption. Option B: It may be toxic by ingestion, inhalation, or skin absorption. Option C: It is toxic by ingestion, inhalation, or skin absorption. Option D: It is toxic by inhalation, ingestion, or skin absorption. " C 5656 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can be associated with transient, usually asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. Option B: It can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. Option C: It can cause transient, asymptomatic elevations in serum aminotransferase levels and uncommon instances of acute liver injury. Option D: It can cause transient and usually asymptomatic elevations in serum aminotransferase levels and rare instances of clinically apparent acute liver injury. " B 60726 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C(=C1)C(=O)C2=CC=C(C=C2)Br)N)CC(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause clinically apparent acute liver injury. Option B: It can cause severe liver toxicity. Option C: It can cause severe and even fatal liver injury. Option D: It can cause severe and sometimes fatal acute liver injury. " B 6914 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1Cl)O)Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is highly corrosive and toxic. Option B: It is a colorless, toxic, and highly reactive gas. Option C: It is a colorless, flammable, and highly toxic gas. Option D: It produces toxic and corrosive fumes including hydrogen chloride and chlorine when heated. " D 213032 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C(=O)N(C(=O)O1)NC2=CC=CC=C2)C3=CC=C(C=C3)OC4=CC=CC=C4 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low mammalian toxicity, but there is some concern regarding its potential for bioaccumulation. Option B: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. Option C: It has relatively low mammalian oral and dermal toxicity. Option D: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. " D 1349907 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C=CNC1=S Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with transient and asymptomatic elevations in serum aminotransferase levels and is a well-known cause of clinically apparent, acute liver injury that can be severe and even fatal. Option B: Therapy with this molecule is associated with transient elevations in serum aminotransferase levels and rare instances of clinically apparent acute liver injury, which can be severe and sometimes fatal. Option C: It has been linked to serum aminotransferase elevations during therapy and to a clinically apparent, idiosyncratic liver injury that is typically cholestatic and self-limited in course. Option D: It more commonly causes transient elevations in serum aminotransferases without jaundice, but has been linked to rare instances of clinically apparent, idiosyncratic liver injury. " C 7207 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=CC(=C1)Cl)OCCCC(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low to moderate acute toxicity, with kidney and liver effects as the main hazard concerns. Option B: It has low inhalation hazard and no apparent skin manifestations or other toxicity in humans. Option C: It has been linked to instances of clinically apparent acute liver injury and long-term therapy to nodular regenerative hyperplasia. Option D: It exhibits moderate acute oral toxicity to mammals but has high acute oral toxicity to birds. " A 7242 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=CC=C1N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may have toxic effects when there are increased exposures resulting from intravenous fluids delivered through plastic tubing or ingesting contaminated foods or water. Option B: It is highly toxic to humans when absorbed through the skin, inhaled as vapor, or swallowed. Option C: It can be very harmful when breathed, ingested, or applied to the skin at very high levels. Option D: It can cause drowsiness, dizziness, headaches, eye, skin, and respiratory tract irritation, and unconsciousness at high levels when inhaled by humans. " B 657181 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option B: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. Option C: It has a modest rate of serum enzyme elevations during therapy, but has not been convincingly linked to instances of clinically apparent acute liver injury. Option D: It has not been linked to instances of serum enzyme elevations during therapy or to clinically apparent liver injury. " C 2249 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NCC(COC1=CC=C(C=C1)CC(=O)N)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare cases of drug-induced liver injury, some of which have been fatal. Option B: It has been linked to rare instances of acute liver injury, some of which have been severe. Option C: It has been linked to rare instances of acute liver injury, a few of which have been fatal. Option D: It has rare instances of acute liver injury, some of which have been fatal. " A 8376 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause clinically apparent liver injury that can be severe and even fatal. Option B: It causes severe eye irritation and moderate skin irritation. Option C: It causes severe respiratory tract irritation and inflammation in humans. Option D: It can cause skin irritation and other toxic consequences. " D 5282452 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC1C2=NC3=CC=CC=C3C(=C2/C=C/[C@H](C[C@H](CC(=O)O)O)O)C4=CC=C(C=C4)F Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with transient and usually mild elevations in serum aminotransferase levels during therapy, but has not been linked to cases of clinically apparent acute liver injury. Option B: It is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, but has had limited use and has yet to be linked with clinically apparent acute liver injury. Option C: It has been associated with frequent serum aminotransferase elevations during therapy and with rare, but sometimes severe and even fatal instances of clinically apparent liver injury. Option D: It is commonly associated with transient elevations in serum aminotransferase during therapy and has been linked to rare, but occasionally severe and even fatal cases of clinically apparent acute liver injury. " B 2724385 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5C[C@H]([C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)O)C)C)C)O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic in large doses. Option B: It has a small margin between toxic and therapeutic doses. Option C: It can produce toxicity in high enough doses. Option D: The margin between toxic and therapeutic doses is small. " B 8892 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by ingestion, inhalation, or skin absorption. Option B: It may be toxic by ingestion, inhalation, or skin absorption. Option C: It is toxic by inhalation, ingestion, or skin absorption. Option D: It may be toxic by ingestion, inhalation, and skin absorption. " D 3352 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C(=C1Cl)N2C(=C(C(=N2)C#N)S(=O)C(F)(F)F)N)Cl)C(F)(F)F Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic to bees, fish, and other aquatic organisms. Option B: It can be toxic to other cockroaches in the same nesting site. Option C: It is toxic to birds, most aquatic organisms, and earthworms. Option D: It is moderately toxic to mammals, birds, earthworms and most aquatic organisms. " B 44073 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1C(F)(F)F)Cl)OC2=CC(=C(C=C2)[N+](=O)[O-])C(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may cause kidney problems above 5mg/day for extended periods. Option B: It causes severe eye irritation and moderate skin irritation. Option C: It causes severe respiratory tract irritation and inflammation in humans. Option D: It causes liver damage in humans and animals. " B 6564 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CCl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been associated with an increased incidence of mammary gland tumors in female rats and liver tumors in male and female mice. Option B: It can cause an unusual form of liver injury called pseudocirrhosis caused by shrinkage of tumor metastases in the liver combined with desmoplastic changes and vascular damage, that can be severe, progressive and even fatal. Option C: It can cause clinically apparent acute liver injury, which can be severe and result in acute liver failure, need for emergency liver transplantation, and death. Option D: It can cause liver injury marked by progressive intrahepatic bile duct injury, some of which resulted in liver transplantation or were fatal. " A 9571107 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CO/N=C/1\\CN(CC1CN)C2=C(C=C3C(=O)C(=CN(C3=N2)C4CC4)C(=O)O)F Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can be associated with rare instances of clinically apparent acute liver injury. Option B: It is linked to rare instances of clinically apparent acute liver injury. Option C: It has been linked to rare instances of clinically apparent acute liver injury. Option D: It has been linked to rare instances of acute liver injury. " D 24586 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]S(=O)(=O)[O-].[Ni+2] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic and has concern about possible carcinogenicity. Option B: It exhibits mild toxicity and is carcinogenic. Option C: It is mildly toxic and carcinogenic. Option D: It is toxic and carcinogenic. " C 998 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)CC=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been implicated as a reproductive toxicant, neurotoxicant, or carcinogen. Option B: It has low inhalation hazard and no apparent skin manifestations or other toxicity in humans. Option C: It has minimal oral absorption and has not been implicated in causing liver test abnormalities or clinically apparent liver injury. Option D: Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity. " A 11234049 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1N=C(N=N1)C2=NC=C(C=C2)C3=C(C=C(C=C3)N4C[C@@H](OC4=O)CO)F Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with a low rate of transient serum aminotransferase elevations, but has yet to be linked to instances of clinically apparent acute liver injury. Option B: It has been linked to a low rate of transient serum aminotransferase elevations during therapy and to rare instances of clinically apparent liver injury. Option C: It has a low rate of transient serum aminotransferase elevations during therapy, but has not been linked to instances of clinically apparent acute liver injury. Option D: It has a low rate of transient serum aminotransferase elevations and has not been clearly linked to clinically apparent acute liver injury. " C 6214 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(Cl)(Cl)Cl)(Cl)(Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause tumors in the glandular stomach in orally exposed rats. Option B: It causes hepatocellular carcinomas (liver tumors) in mice following oral exposure. Option C: It can cause liver and kidney tumors in mice from dermal exposure. Option D: It increases the incidence of liver tumors in mice orally exposed to it. " B 24502 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-][Cr](=O)(=O)O[Cr](=O)(=O)[O-].[K+].[K+] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is more toxic than other oxidation states of the chromium atom. Option B: It is more toxic than other oxidation states of the chromium atom due to its greater ability to enter cells and higher redox potential. Option C: It is more toxic due to its greater ability to enter cells and higher redox potential. Option D: It has a greater ability to enter cells and higher redox potential. " B 6234 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@H](C(=O)NO1)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, but has had limited use and has yet to be linked with clinically apparent acute liver injury. Option B: It appears to have little or no hepatotoxic potential, but its role in reported cases of liver injury with combination therapy cannot always be excluded. Option C: It is associated with transient and usually mild elevations in serum aminotransferase levels during therapy, but has not been linked to cases of clinically apparent acute liver injury. Option D: It has been associated with frequent serum aminotransferase elevations during therapy and with rare, but sometimes severe and even fatal instances of clinically apparent liver injury. " B 3372 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute cholestatic liver injury. Option B: It can cause mild and transient serum enzyme elevations and is a rare cause of clinically apparent acute cholestatic liver injury. Option C: It can cause mild and transient serum enzyme elevations and has been linked to rare instances of clinically apparent cholestatic liver injury. Option D: It can cause mild and transient serum enzyme elevations and is a rare cause of clinically apparent acute and chronic cholestatic liver injury. " C 10113978 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can be associated with transient, usually asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. Option B: It has been associated with frequent serum aminotransferase elevations during therapy and with rare, but sometimes severe and even fatal instances of clinically apparent liver injury. Option C: It is associated with transient and usually mild elevations in serum aminotransferase levels during therapy, but has not been linked to cases of clinically apparent acute liver injury. Option D: It is commonly associated with transient elevations in serum aminotransferase during therapy and has been linked to rare, but occasionally severe and even fatal cases of clinically apparent acute liver injury. " D 41384 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCN(CCCC)SN(C)C(=O)OC1=CC=CC2=C1OC(C2)(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. Option B: It has low mammalian oral and dermal toxicity. Option C: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. Option D: It has relatively low mammalian oral and dermal toxicity. " D 8019 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is a central nervous system toxicant and has been shown to damage the lungs and kidneys in animal testing. Option B: It can cause irritation of the eyes, skin, nose, throat, and lungs, and damage to the brain and nervous system. Option C: It can cause eye and skin irritation and toxic effects on the liver, kidneys, and central and peripheral nervous systems. Option D: It may cause severe damage to the skin, eyes, respiratory tract, and mucous membranes and cause depression of the central nervous system in humans. " A 11167602 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is commonly associated with transient elevations in serum aminotransferase levels during treatment, but with only rare instances of clinically apparent acute liver injury. Option B: Therapy with this molecule is associated with transient elevations in serum aminotransferase levels and rare instances of clinically apparent acute liver injury, which can be severe and sometimes fatal. Option C: It can be associated with transient, usually asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. Option D: It has been associated with frequent serum aminotransferase elevations during therapy and with rare, but sometimes severe and even fatal instances of clinically apparent liver injury. " D 23976 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Cr] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is less potent but less toxic than the molecule produced in the 1950s. Option B: It is much less toxic than chromium (VI). Option C: It is a highly toxic compound that volatizes slightly at ordinary temperature and appreciably at 100 degrees C. Option D: It is less toxic than phenytoin. " B 18502 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(CC1)N=C=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is very toxic by ingestion, inhalation, and skin absorption. Option B: It is very toxic by inhalation, skin absorption, and ingestion. Option C: It is very toxic by ingestion, inhalation, or skin absorption. Option D: It is very toxic by inhalation and skin absorption. " B 10127622 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with transient and usually mild elevations in serum aminotransferase levels during therapy, but has not been linked to cases of clinically apparent acute liver injury. Option B: It can be associated with transient, usually asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. Option C: It can cause transient and usually asymptomatic elevations in serum aminotransferase levels and is a rare cause of clinically apparent, acute liver injury. Option D: It can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. " A 14969 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H]1[C@H]([C@@](C[C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)[C@H]([C@H](C(=O)N[C@H](C(=O)N[C@H]5C(=O)N[C@@H]7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)[C@H](NC(=O)[C@H]([C@@H](C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)[C@@H](CC(C)C)NC)O)Cl)CO)O)O)(C)N)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can be toxic to other cockroaches in the same nesting site. Option B: It is toxic to kidneys and the inner ear. Option C: It is toxic to non-target organisms. Option D: It is extremely toxic to birds. " B 3286 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)SCSP(=S)(OCC)OCC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by ingestion, inhalation, or skin absorption. Option B: It is toxic by inhalation, skin absorption, and ingestion. Option C: It is toxic by inhalation, skin absorption, and/or ingestion. Option D: It is toxic by inhalation, skin absorption, or ingestion. " C 768 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C#N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is extremely poisonous. Option B: It is extremely toxic to birds. Option C: It is a poisonous metalloid. Option D: It is a poisonous inorganic compound. " A 2157 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause serious toxicity and possibly death. Option B: It can cause severe and sometimes fatal acute liver injury. Option C: It can cause acute liver failure in overdose. Option D: It can cause severe liver toxicity. " A 14987 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1C[C@@H](C=C2[C@H]1CC3=CNC4=CC=CC2=C34)CO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause ergotism, a disease causing convulsive and gangrenous symptoms. Option B: It can cause convulsive and gangrenous symptoms. Option C: It has been associated with occasional cases of severe and distinctive acute hepatic failure. Option D: It has been linked to severe cases of acute hepatitis which can be fatal. " B 6570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)C=C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may be slightly toxic by ingestion, inhalation, and skin absorption. Option B: It exhibits toxicity by inhalation and irritation to the eyes and mucous membranes. Option C: It is very toxic by inhalation and may irritate the eyes and mucous membranes. Option D: It can cause burns to skin, eyes, and mucous membranes. " D 6423 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C([N+](=O)[O-])(Cl)(Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause vertigo, drowsiness, headache, anorexia, and irritation of the eyes, nose, throat, and lungs. Option B: It is moderately toxic by ingestion and vapors may irritate skin and eyes. Option C: Acute and chronic inhalation exposure to it in humans can result in respiratory symptoms, and eye, nose, and throat irritation. Option D: It is poisonous by inhalation and irritates eyes, nose, and throat. " D 2513 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[As](=O)(C)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by ingestion and skin absorption. Option B: It is toxic by ingestion, inhalation, and skin absorption. Option C: It is toxic by ingestion and irritating to skin and eyes. Option D: It is toxic and irritating to skin, eyes, etc. " C 2871 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OC1=CC2=C(C=C1)C(=C(C(=O)O2)Cl)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is highly toxic to aquatic life, particularly fish. Option B: It is toxic to both insects and mites. Option C: It is highly toxic to mammals and insects. Option D: It is selectively more toxic to insects than mammals. " B 216239 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with rare instances of clinically apparent, acute liver injury that can be severe and even fatal. Option B: It can cause clinically apparent acute liver injury that can be severe and even fatal. Option C: It can cause clinically apparent liver injury that can be severe and even fatal. Option D: It has been linked to rare instances of acute liver injury that can be severe and even fatal. " C 28780 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCNC(=O)N1C2=CC=CC=C2N=C1NC(=O)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has relatively low mammalian oral and dermal toxicity. Option B: It has low mammalian oral and dermal toxicity. Option C: It has heightened effect on fungal rather than mammalian microtubules. Option D: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. " C 4915 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)NC(=O)C1=CC=C(C=C1)CNNC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of idiosyncratic, clinically apparent acute liver injury. Option B: It has been linked to rare cases of idiosyncratic, clinically apparent liver injury. Option C: It has been linked to rare instances of clinically apparent, idiosyncratic liver injury. Option D: It has been associated with idiosyncratic, clinically apparent acute liver injury. " D 5493444 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[C@@H](CC1=CC(=C(C=C1)OC)OCCCOC)C[C@@H]([C@H](C[C@@H](C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of idiosyncratic drug induced liver disease. Option B: It has been linked to rare instances of clinically apparent, idiosyncratic drug induced liver disease. Option C: It has been linked to rare cases of idiosyncratic, clinically apparent liver injury. Option D: It has been linked to rare instances of clinically apparent, idiosyncratic liver injury. " C 7855 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC#N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is highly toxic by ingestion, inhalation, or skin contact. Option B: It is harmful upon prolonged exposure to the vapors or skin contact. Option C: It is toxic by ingestion, inhalation, or skin absorption. Option D: It is toxic by inhalation, ingestion, or skin absorption. " B 679 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CS(=O)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can transport toxic solutes through the skin as an excellent solvent. Option B: It is toxic by inhalation and skin absorption. Option C: It is toxic by ingestion, inhalation, and skin absorption. Option D: It is toxic by inhalation, ingestion, and skin absorption. " A 441445 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=C1C[C@H]1C[C@@H](C(=O)O)NC(=O)CC[C@@H](C(=O)O)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic if ingested and is a causative agent of Jamaican Vomiting Sickness. Option B: It is moderately toxic to birds, most aquatic organisms, honeybees, and earthworms. Option C: It is moderately toxic to mammals, birds, earthworms and most aquatic organisms. Option D: It is moderately toxic to humans, mammals, birds and most aquatic organisms. " A 5419 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CC(C2=CC=CC=C2C1)C3=NCCN3 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity. Option B: It can cause illness by inhalation, skin absorption and/or ingestion. Option C: It has low inhalation hazard and no apparent skin manifestations or other toxicity in humans. Option D: It can cause drug overdose and toxicity from accidental ingestion due to its profound sedation effects. " D 6196 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=NO1)C2=CC=CC=C2)C(=O)N[C@H]3[C@@H]4N(C3=O)[C@H](C(S4)(C)C)C(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is commonly associated with transient elevations in serum aminotransferase during therapy and has been linked to rare, but occasionally severe and even fatal cases of clinically apparent acute liver injury. Option B: It is associated with transient and asymptomatic elevations in serum aminotransferase levels and is a well-known cause of clinically apparent, acute liver injury that can be severe and even fatal. Option C: It more commonly causes transient elevations in serum aminotransferases without jaundice, but has been linked to rare instances of clinically apparent, idiosyncratic liver injury. Option D: It has been linked to serum aminotransferase elevations during therapy and to a clinically apparent, idiosyncratic liver injury that is typically cholestatic and self-limited in course. " C 33741 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C[C@H]1CCCC[C@@]1(C2=CC(=CC=C2)OC)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause acute liver failure in overdose. Option B: It can cause severe and even fatal liver injury. Option C: It can cause severe and sometimes fatal acute liver injury. Option D: It can cause clinically apparent acute liver injury. " A 439530 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low to moderate acute toxicity, with kidney and liver effects as the main hazard concerns. Option B: It exhibits moderate acute oral toxicity to mammals but has high acute oral toxicity to birds. Option C: It has low inhalation hazard and no apparent skin manifestations or other toxicity in humans. Option D: It is toxic to both prokaryotic and eukaryotic cells, resulting in significant cell death at appropriate doses. " D 13192 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCCN=C=O)CCN=C=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may cause headaches, dizziness, fatigue, drowsiness, burning substernal pain, nausea, vomiting, cough, labored breathing, chest tightness, pulmonary irritation, pulmonary edema, and tremors in humans. Option B: Acute inhalation exposure to it may cause irritation of the eyes, cough, wheezing, asthmatic symptoms, pulmonary edema, pneumonia, dizziness, weakness, headache, and chest pains. Option C: Acute exposure to high concentrations of it can cause pulmonary edema, coughing, and shortness of breath in humans. Option D: Acute exposure to high levels of it may cause severe dermatitis, eye irritation and tearing, asthma, gastritis, renal failure, vertigo, tremors, convulsions, and coma in humans. " C 174 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CO)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: Acute exposure to large quantities of it causes three stages of health effects in humans: central nervous system depression, followed by cardiopulmonary effects, and later renal damage. Option B: It induces pathological changes in bone (osteolathyrism) and blood vessels (angiolathyrism) of experimental animals without damaging the nervous system. Option C: It can cause effects on the liver, kidney, and central nervous system (CNS) from inhalation and oral exposure, as well as effects on the liver and immune system from oral exposure. Option D: Acute inhalation exposure to it may cause irritation of the eyes, cough, wheezing, asthmatic symptoms, pulmonary edema, pneumonia, dizziness, weakness, headache, and chest pains. " A 27982 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CCl)P(=O)(O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is highly toxic to humans when absorbed through the skin, inhaled as vapor, or swallowed. Option B: Acute exposure to high concentrations of it can cause pulmonary edema, coughing, and shortness of breath in humans. Option C: It shows a moderate level of toxicity to fish, daphnia and earthworms but is relatively non-toxic to honey bees, birds and algae. Option D: Its toxicity is very low, and any of it used on the plant is converted very quickly to ethylene. " D 10178 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C1=C(C=C(C=C1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by ingestion and skin absorption. Option B: It is toxic by inhalation, ingestion, and skin absorption. Option C: It is toxic by inhalation, ingestion, or skin absorption. Option D: It is toxic by ingestion, inhalation, or skin absorption. " A 60490 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C1=CC2=CC=CC=C2S1)N(C(=O)N)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare cases of drug-induced liver disease and is considered contraindicated in patients with active liver disease. Option B: It has been linked to rare instances of clinically apparent drug induced liver disease. Option C: It has been linked to rare instances of clinically apparent acute drug induced liver injury. Option D: It has been linked to several instances of clinically apparent drug induced liver injury. " A 24744 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC=C1)NC(=O)OC2=CC=CC(=C2)NC(=O)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. Option B: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. Option C: It has relatively low mammalian oral and dermal toxicity. Option D: It has low mammalian oral and dermal toxicity. " C 5206 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(OC(C(F)(F)F)C(F)(F)F)F Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been implicated in rare single case reports of severe acute liver injury similar to halothane hepatitis. Option B: It has been linked to instances of clinically apparent acute liver injury and long-term therapy to nodular regenerative hyperplasia. Option C: It is a cause of clinically apparent acute drug induced liver injury and is no longer recommended as a first line antifungal agent. Option D: It can cause mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. " A 441207 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5CC[C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)C)C)C)O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may be toxic by ingestion. Option B: It has longer lasting toxic effects similar to those of digoxin. Option C: It is moderately toxic by ingestion. Option D: It may be slightly toxic by ingestion. " B 6327 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low inhalation hazard and no apparent skin manifestations or other toxicity in humans. Option B: It has low dermal, oral, and inhalation toxicity. Option C: It has a faint, sweet odor that is noticeable only at levels that may be toxic. Option D: It has low to moderate acute toxicity, with kidney and liver effects as the main hazard concerns. " C 132971 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC=C4C5=CN=CC=C5)C)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been associated with rare instances of acute, clinically apparent liver injury. Option B: It has been linked to rare instances of clinically apparent acute drug induced liver injury. Option C: It is associated with rare but potentially severe instances of acute liver injury with jaundice. Option D: It has been linked to rare instances of clinically apparent acute liver injury with jaundice. " C 300 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)O)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause neurotoxicity in humans, including numbness, cyanosis, hyperesthesia, and muscle spasms. Option B: It affects the liver, including hepatitis and jaundice, and central nervous system effects, such as depression and irritability. Option C: It may cause severe damage to the skin, eyes, respiratory tract, and mucous membranes and cause depression of the central nervous system in humans. Option D: It induces pathological changes in bone (osteolathyrism) and blood vessels (angiolathyrism) of experimental animals without damaging the nervous system. " C 43815 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It does not specify the toxicity. Option B: It exhibits acute liver toxicity. Option C: It can cause serious toxicity and possibly death. Option D: It exhibits rare acute liver toxicity. " A 54686904 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)NCC(=O)NC1=CC(=C2C[C@H]3C[C@H]4[C@@H](C(=O)C(=C([C@]4(C(=O)C3=C(C2=C1O)O)O)O)C(=O)N)N(C)C)N(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is sometimes accompanied by minor aminotransferase elevations, but has not been definitely associated with clinically apparent liver injury with jaundice. Option B: It has been associated with frequent serum aminotransferase elevations during therapy and with rare, but sometimes severe and even fatal instances of clinically apparent liver injury. Option C: It is commonly associated with transient elevations in serum aminotransferase levels during treatment, but with only rare instances of clinically apparent acute liver injury. Option D: It is associated with transient and usually mild elevations in serum aminotransferase levels during therapy, but has not been linked to cases of clinically apparent acute liver injury. " A 62672 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [Be+2].O.O.O.O.[O-]S(=O)(=O)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is highly toxic by inhalation and ingestion. Option B: It is toxic by ingestion and inhalation. Option C: It is toxic by inhalation and ingestion. Option D: It may be toxic by inhalation or ingestion. " A 7416 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It causes hepatocellular carcinomas (liver tumors) in mice following oral exposure. Option B: Animals orally exposed to it observed kidney, liver, and mammary gland tumors. Option C: It can cause liver and kidney tumors in mice from dermal exposure. Option D: It results in effects on the blood, such as methemoglobinemia. " D 2912 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C(C1C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C=C(Cl)Cl)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is neurotoxic and can induce spastic myelopathy in rabbits. Option B: It acts as a fast-acting neurotoxin in insects. Option C: It is a neurotoxin that blocks neural messages and binds particularly tightly in the central nervous system of insects, causing rapid death. Option D: It can cause a potentially lethal central nervous system condition known as locoism in livestock. " B 7699 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCNC1=CC=C(C=C1)C(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause drug overdose and toxicity from accidental ingestion due to its profound sedation effects. Option B: It has low inhalation hazard and no apparent skin manifestations or other toxicity in humans. Option C: It is associated with a risk for severe toxicity and overdose, especially in children. Option D: Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity. " C 16231 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of clinically apparent drug induced liver disease. Option B: It has been linked to rare instances of clinically apparent acute drug induced liver injury. Option C: It has been linked to rare cases of clinically apparent drug induced liver disease. Option D: It is linked to rare cases of clinically apparent drug-induced liver disease. " D 12228 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN=C=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with high rates of enzyme elevations and acute liver injury due to sinusoidal obstruction syndrome. Option B: It may result in adverse health conditions from inhalation. Option C: It resulted in deaths and adverse health effects in survivors due to acute inhalation exposure. Option D: It can cause severe liver damage and some kidney damage from acute inhalation exposure. " C 2345 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)COC(=O)C2=CC=CC=C2 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits toxicity by inhalation, skin absorption, and ingestion. Option B: It is lethal to mites and useful in the treatment of scabies. Option C: It exhibits toxicity by inhalation and irritation to the eyes and mucous membranes. Option D: It is toxic by inhalation, skin absorption, and ingestion. " B 3033637 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN/C(=C\\[N+](=O)[O-])/NCCSCC1=CSC(=N1)CN(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is linked to rare instances of clinically apparent acute liver injury. Option B: It has been linked to rare instances of clinically apparent liver injury. Option C: It has been associated with rare instances of clinically apparent liver injury. Option D: It can be associated with rare instances of clinically apparent acute liver injury. " A 5284429 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O.O.O.O.O.O.[O-]S(=O)(=O)[O-].[Ni+2] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic and carcinogenic. Option B: It is toxic and may be carcinogenic. Option C: It is highly toxic and carcinogenic. Option D: It is mildly toxic and carcinogenic. " A 342 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=CC=C1)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can be very harmful when breathed, ingested, or applied to the skin at very high levels. Option B: It is associated with mild and transient serum enzyme elevations and with moderate-to-severe clinically apparent liver injury when abused by intravenous administration or the sublingual formations. Option C: It is highly toxic to humans when absorbed through the skin, inhaled as vapor, or swallowed. Option D: It may have toxic effects when there are increased exposures resulting from intravenous fluids delivered through plastic tubing or ingesting contaminated foods or water. " A 3397 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to numerous cases of acute liver injury, which are frequently severe and can be fatal. Option B: It has been linked to rare cases of drug-induced liver injury, some of which have been fatal. Option C: It has been linked to rare instances of acute liver injury, a few of which have been fatal. Option D: It has been linked to rare instances of acute liver injury, some of which have been severe. " A 2955 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of clinically apparent, idiosyncratic drug induced liver disease. Option B: It has been linked to rare instances of clinically apparent, idiosyncratic liver injury. Option C: It has been linked with rare cases of idiosyncratic liver injury, similar to that seen with the sulfonamides. Option D: It is associated with rare instances of idiosyncratic, clinically apparent liver injury that are usually mild and rapidly reversible on stopping. " C 5943 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)(Cl)(Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by inhalation, skin absorption, or ingestion. Option B: It can cause illness by inhalation, skin absorption, and/or ingestion. Option C: It can cause illness by inhalation, skin absorption and/or ingestion. Option D: It may cause illness by inhalation, skin absorption, and/or ingestion. " D 3821 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC1(CCCCC1=O)C2=CC=CC=C2Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause inflammation and irritation to the urinary bladder and urethra, and similar changes have recently been described in the biliary tract, resulting in an acute or chronic cholestatic liver injury that can resemble sclerosing cholangitis. Option B: It can lead to acute psychosis, aggressive and violent behaviors, and overdoses can cause status epilepticus, hyperthermia, rhabdomyolysis and subsequent renal, respiratory and hepatic failure. Option C: It has been associated with rare instances of idiosyncratic acute liver injury; in addition, prolonged high dose therapy can cause the “infusion syndrome” which is marked by bradyarrhythmias, metabolic acidosis, rhabdomyolysis, hyperlipidemia and an enlarged or fatty liver. Option D: Ingestion of a large amount of this molecule can result in tinnitus, dizziness, headache, nausea, vomiting, dyspnea, erosion of the gastric mucosa, edema of internal organs, cyanosis, convulsions, delirium, and collapse in humans. " A 5237 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(=O)O)F Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is extremely toxic to birds. Option B: It is highly toxic to aquatic life, particularly fish. Option C: It is highly toxic to mammals and insects. Option D: It is highly toxic to honeybees. " C 3082 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNC(=O)CSP(=S)(OC)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is mildly toxic by inhalation. Option B: It is moderately toxic by ingestion. Option C: It is mildly toxic by ingestion and inhalation. Option D: It affects the central nervous system and is moderately toxic. " D 3950 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(CC1)NC(=O)N(CCCl)N=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been associated with serum enzyme elevations during therapy and with rare instances of clinically apparent acute liver injury. Option B: It can cause mild and transient serum enzyme elevations and is a rare cause of clinically apparent acute liver injury. Option C: It is associated with minor transient serum enzyme elevations and has been linked to rare cases of clinically apparent acute liver injury. Option D: It can cause serum enzyme elevations during therapy and rare instances of clinically apparent acute liver injury. " C 8378 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has minimal oral absorption and has not been implicated in causing liver test abnormalities or clinically apparent liver injury. Option B: It has minimal oral absorption and has not been linked to instances of acute liver injury. Option C: It has not been linked to significant serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. Option D: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. " B 247 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+](C)(C)CC(=O)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has not been linked to significant serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. Option B: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury. Option C: It has not been linked to instances of serum enzyme elevations during therapy or to clinically apparent liver injury. Option D: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. " C 5472 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN(CC2=C1SC=C2)CC3=CC=CC=C3Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause neutropenia, aplastic anemia, thrombotic thrombocytopenia purpura, and agranulocytosis. Option B: It can cause minor transient serum enzyme elevations and has been linked to cases of acute liver injury including cholestatic hepatitis and acute veno-occlusive disease. Option C: It exhibits toxicity against HCT116 cells (human colorectal cancer cells) by triggering apoptotic cell death. Option D: It has been linked to cases of acute liver injury, including acute cholestatic hepatitis and veno-occlusive disease. " A 6115 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by skin absorption and inhalation. Option B: It is toxic by inhalation and by skin absorption. Option C: It is very toxic by inhalation and skin absorption. Option D: It is very toxic by skin absorption and inhalation. " A 1983 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)NC1=CC=C(C=C1)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It contributes to hepatotoxicity. Option B: It is associated with a risk of hepatotoxicity. Option C: It has a lower risk of hepatotoxicity. Option D: It can cause hepatotoxicity after an overdose. " D 12797557 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[C@@H](C1=CC=C(C=C1)OC(F)F)C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can harm sensitive individuals but is generally harmless to human beings in the concentrations used in such products. Option B: It is generally harmless but can harm sensitive individuals. Option C: It can harm sensitive individuals, but in general, it is harmless to human beings. Option D: It is generally harmless to human beings but can harm sensitive individuals. " D 3033 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. Option B: It can cause mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. Option C: It is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy and rarely with clinically apparent acute liver injury. Option D: It is frequently associated with mild serum aminotransferase elevations and, in rare instances, can lead to serious clinically apparent, acute or chronic liver disease. " D 3893 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCC(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has comparatively lower toxicity. Option B: It has a very low toxicity. Option C: It has low acute toxicity. Option D: It generally has been shown to be of low acute toxicity. " B 1647 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CN)C#N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may cause severe damage to the skin, eyes, respiratory tract, and mucous membranes and cause depression of the central nervous system in humans. Option B: It can result in weakness, headache, dizziness, nausea, abdominal pain, myotonia, hypotension, renal and hepatic injury, and delayed neuropathy. Option C: It can cause cataracts, skin lesions, weight loss, and affect the bone marrow, central nervous system, and cardiovascular system. Option D: It induces pathological changes in bone (osteolathyrism) and blood vessels (angiolathyrism) of experimental animals without damaging the nervous system. " D 8640 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC=C2N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is very toxic by inhalation and ingestion. Option B: It may be slightly toxic by ingestion. Option C: It is moderately toxic by ingestion. Option D: It is slightly toxic. " B 3011155 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=NC(=NC2=C1N=CN2[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)O)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of clinically apparent acute liver injury. Option B: It is linked to rare instances of clinically apparent acute liver injury. Option C: It has been linked to rare instances of clinically apparent acute liver injury with jaundice. Option D: It is associated with rare instances of clinically apparent acute liver injury. " C 7111 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C2=CC=C(C=C2)N)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may be toxic by ingestion, inhalation, and skin absorption. Option B: It is toxic by ingestion, inhalation, and skin absorption. Option C: It is toxic by inhalation, ingestion, or skin absorption. Option D: It is toxic by ingestion, inhalation, or skin absorption. " B 7835 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C(O1)CCl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may cause headaches, dizziness, fatigue, drowsiness, burning substernal pain, nausea, vomiting, cough, labored breathing, chest tightness, pulmonary irritation, pulmonary edema, and tremors in humans. Option B: It can cause nausea, vomiting, cough, labored breathing, inflammation of the lung, pulmonary edema, and renal lesions at high levels of exposure. Option C: Acute inhalation exposure to it may cause irritation of the eyes, cough, wheezing, asthmatic symptoms, pulmonary edema, pneumonia, dizziness, weakness, headache, and chest pains. Option D: It can cause symptoms of acute inhalation exposure such as dizziness, nausea, vomiting, diarrhea, loss of consciousness, and decreased blood pressure. " B 54678486 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)CC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare cases of idiosyncratic, clinically apparent liver injury. Option B: It is associated with rare instances of idiosyncratic, clinically apparent liver injury that are usually mild and rapidly reversible on stopping. Option C: It has been associated with idiosyncratic, clinically apparent acute liver injury. Option D: It has been linked to rare instances of idiosyncratic, clinically apparent acute liver injury. " B 12695 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(F)(F)F)C(F)(F)F Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is a colorless, toxic, and highly reactive gas. Option B: It is highly toxic to mammals and insects. Option C: It is highly corrosive and toxic. Option D: It is highly toxic to aquatic life, particularly fish. " A 3637 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=NN=C2NN Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of clinically apparent acute drug induced liver injury. Option B: It has been linked to several instances of clinically apparent drug induced liver injury. Option C: It has been linked to several forms of acute liver injury as well as a lupus-like syndrome. Option D: It is a known cause of clinically apparent acute drug induced liver injury. " C 7768 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(=O)NCC1 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause illness by inhalation, skin absorption, and/or ingestion. Option B: It may cause illness by inhalation, skin absorption, and/or ingestion. Option C: It can cause headaches, malaise, confusion, and nervous irritation when inhaled. Option D: It can cause headaches, vertigo, and effects on the blood when inhaled. " C 971 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(=O)O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is a uremic toxin and has been involved in the progression of renal failure. Option B: It is considered to be a uremic toxin and is poorly cleared with dialysis. Option C: It has toxic properties and suggests that it is an uremic toxin. Option D: It is considered a mild toxin. " D 7814 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1N)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: Acute exposure to high levels of it may cause severe dermatitis, eye irritation and tearing, asthma, gastritis, renal failure, vertigo, tremors, convulsions, and coma in humans. Option B: Ingestion of a large amount of this molecule can result in tinnitus, dizziness, headache, nausea, vomiting, dyspnea, erosion of the gastric mucosa, edema of internal organs, cyanosis, convulsions, delirium, and collapse in humans. Option C: It can lead to acute psychosis, aggressive and violent behaviors, and overdoses can cause status epilepticus, hyperthermia, rhabdomyolysis and subsequent renal, respiratory and hepatic failure. Option D: It has been associated with rare instances of idiosyncratic acute liver injury; in addition, prolonged high dose therapy can cause the “infusion syndrome” which is marked by bradyarrhythmias, metabolic acidosis, rhabdomyolysis, hyperlipidemia and an enlarged or fatty liver. " A 445643 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can rarely result in clinically apparent, cholestatic liver injury. Option B: It is a rare cause of clinically apparent acute cholestatic liver injury. Option C: It can cause rare instances of clinically apparent, acute cholestatic liver injury. Option D: It has been linked to rare instances of clinically apparent cholestatic liver injury. " D 3599 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is often accompanied by transient mild-to-moderate serum aminotransferase elevations during the first 1 or 2 weeks of treatment, but has not been implicated in cases of clinically apparent liver injury with jaundice. Option B: It is associated with transient, asymptomatic serum aminotransferase elevations and is a known cause of clinically apparent acute drug-induced liver injury. Option C: It is associated with transient and asymptomatic elevations in serum aminotransferase levels and is a well-known cause of clinically apparent, acute liver injury that can be severe and even fatal. Option D: It is commonly associated with transient elevations in serum aminotransferase during therapy and has been linked to rare, but occasionally severe and even fatal cases of clinically apparent acute liver injury. " A 5328940 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with transient elevations in serum aminotransferase levels during treatment and rare instances of clinically apparent acute liver injury. Option B: It is associated with transient elevations in serum aminotransferase and bilirubin levels and rare instances of clinically apparent acute liver injury. Option C: It has transient elevations in serum aminotransferase and bilirubin levels and rare instances of clinically apparent acute liver injury. Option D: It is associated with frequent elevations in serum aminotransferase levels and with rare instances of clinically apparent acute liver injury. " C 5284616 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has mild serum enzyme elevations and has been linked to rare instances of clinically apparent cholestatic liver injury. Option B: It can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute cholestatic liver injury. Option C: It can cause mild and transient serum enzyme elevations and has been linked to rare instances of clinically apparent cholestatic liver injury. Option D: It can cause mild and transient serum enzyme elevations and is a rare cause of clinically apparent acute cholestatic liver injury. " A 53232 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, but has had limited use and has yet to be linked with clinically apparent acute liver injury. Option B: It is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. Option C: It has mild, asymptomatic and self-limited serum aminotransferase elevations during therapy and rarely with clinically apparent acute liver injury. Option D: It can cause mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. " C 176870 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has transient elevations in serum aminotransferase levels during therapy and rare instances of clinically apparent acute liver injury. Option B: It is associated with frequent elevations in serum aminotransferase levels and with rare instances of clinically apparent acute liver injury. Option C: It is associated with a moderate rate of transient elevations in serum aminotransferase levels during therapy and with rare instances of clinically apparent acute liver injury. Option D: It is associated with transient elevations in serum aminotransferase levels during treatment and rare instances of clinically apparent acute liver injury. " A 7966 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CCC(CC1)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by inhalation, skin absorption, or ingestion. Option B: It may be toxic by ingestion, inhalation, or skin absorption. Option C: It is toxic by inhalation, ingestion, or skin absorption. Option D: It may be toxic by inhalation or skin exposure. " D 221493 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)O)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is commonly associated with transient elevations in serum aminotransferase levels during treatment, but with only rare instances of clinically apparent acute liver injury. Option B: It has minor elevations in serum aminotransferase levels, but it has not been linked to instances of clinically apparent acute liver injury with jaundice. Option C: It is associated with transient elevations in serum aminotransferase levels during therapy and has been reported to cause clinically apparent acute liver injury and rare instances of death. Option D: It is associated with transient elevations in serum aminotransferase levels during treatment and rare instances of clinically apparent acute liver injury. " B 398 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)[N+](=O)[O-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause severe liver damage and some kidney damage from acute inhalation exposure. Option B: It can cause symptoms of acute inhalation exposure such as dizziness, nausea, vomiting, diarrhea, loss of consciousness, and decreased blood pressure. Option C: It can cause chronic exposure of uremic toxins, leading to conditions such as renal damage, chronic kidney disease, and cardiovascular disease. Option D: It is associated with hemolytic anemia, damage to the liver, and neurological damage from acute exposure. " A 442614 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=C2C(=C1O)[C@]3(C(=CC(=C(C3=O)C(=O)C)O)O2)C)C(=O)C)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has rarely been implicated in causing clinically apparent acute liver injury. Option B: It can be associated with rare instances of clinically apparent acute liver injury. Option C: It has been linked to instances of clinically apparent, acute liver injury when taken orally. Option D: It has rare instances of clinically apparent acute liver injury. " C 281 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [C-]#[O+] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with rare instances of clinically apparent, acute liver injury that can be severe and even fatal. Option B: It may be fatal when exposed to carbon monoxide rich atmospheres. Option C: It has been linked to rare but convincing instances of liver injury that can be severe and even fatal. Option D: It has been linked to rare instances of acute liver injury that can be severe and even fatal. " B 9570071 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(/C=N/OC(=O)NC)SC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic to fish. Option B: It is extremely toxic to Hymenoptera. Option C: It is extremely toxic to birds. Option D: It is moderately toxic to fish. " B 39186 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(=O)O[C@@H]1[C@@H](SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been associated with serum enzyme elevations during therapy and with rare instances of clinically apparent acute liver injury. Option B: It can cause serum enzyme elevations during therapy and rare instances of clinically apparent acute liver injury. Option C: It has serum enzyme elevations and has been linked to rare instances of clinically apparent liver injury. Option D: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. " C 23677060 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O[As](=O)(O)[O-].[Na+] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is a poisonous inorganic compound. Option B: It is poisonous. Option C: It exhibits poisonous toxicity. Option D: It is a poisonous metalloid. " D 4168 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause mild and transient serum enzyme elevations and is a rare cause of clinically apparent acute cholestatic liver injury. Option B: It has been linked to rare instances of clinically apparent liver injury that are typically cholestatic and can be associated with bile duct loss. Option C: It can cause mild and transient serum enzyme elevations and has been linked to rare instances of clinically apparent cholestatic liver injury. Option D: It can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute cholestatic liver injury. " B 23668197 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [O-]Cl=O.[Na+] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of clinically apparent liver injury. Option B: It is non-toxic. Option C: It is relatively nontoxic and noncombustible. Option D: It is non-addictive and non-toxic. " B 6259 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)C(=O)CBr Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may be toxic by ingestion, inhalation, or skin absorption. Option B: It is toxic by inhalation, ingestion, and skin absorption. Option C: It is toxic by inhalation, skin absorption, or ingestion. Option D: It is toxic by inhalation, skin absorption, and ingestion. " B 8800 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C(=O)NC1=CC=C(C=C1)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is highly toxic to aquatic life, particularly fish. Option B: It is moderately toxic by ingestion. Option C: It is toxic to fish. Option D: It is moderately toxic to fish. " B 931 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C=CC=CC2=C1 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It can cause severe liver damage and some kidney damage from acute inhalation exposure. Option B: It is associated with hemolytic anemia, damage to the liver, and neurological damage from acute exposure. Option C: It can cause chronic exposure of uremic toxins, leading to conditions such as renal damage, chronic kidney disease, and cardiovascular disease. Option D: It can cause symptoms of acute inhalation exposure such as dizziness, nausea, vomiting, diarrhea, loss of consciousness, and decreased blood pressure. " B 222 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is linked to rare cases of clinically apparent drug-induced liver disease. Option B: It may result in adverse health conditions from inhalation. Option C: It resulted in deaths and adverse health effects in survivors due to acute inhalation exposure. Option D: It may result in adverse health effects. " B 4420 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COP(=O)(OC)OC(C(Cl)(Cl)Br)Br Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may be toxic by ingestion, inhalation, and skin absorption. Option B: It can cause illness by inhalation, skin absorption and/or ingestion. Option C: It is toxic by inhalation, skin absorption, and/or ingestion. Option D: It can cause illness by inhalation, skin absorption, and/or ingestion. " D 6294 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may be toxic by ingestion, inhalation, or skin absorption. Option B: It is toxic by inhalation, skin absorption, or ingestion. Option C: It may be toxic by ingestion, inhalation, and skin absorption. Option D: It is toxic by ingestion, inhalation, or skin absorption. " B 9033 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1CN1 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It may cause kidney problems above 5mg/day for extended periods. Option B: It causes severe eye irritation and moderate skin irritation. Option C: It causes liver damage in humans and animals. Option D: It causes severe respiratory tract irritation and inflammation in humans. " D 7839 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CBr)Br Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: Animals orally exposed to it observed kidney, liver, and mammary gland tumors. Option B: It can cause liver and kidney tumors in mice from dermal exposure. Option C: It may result in toxic effects to the liver, kidney, and the testis. Option D: It can cause effects to the lungs, liver, spleen, and thyroid in animals chronically exposed to it via inhalation. " C 84029 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)O)(C)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare but convincing instances of liver injury that can be severe and even fatal. Option B: It has been linked to rare instances of acute liver injury, some of which have been severe. Option C: It has been linked to rare, but occasionally severe cases of acute liver injury. Option D: It has been linked to rare instances of acute liver injury that can be severe and even fatal. " D 1322 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CNNC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is very toxic by inhalation and skin absorption. Option B: It is very toxic by inhalation, skin absorption, and ingestion. Option C: It is very toxic by ingestion, inhalation, and skin absorption. Option D: It is toxic by ingestion, inhalation, and skin absorption. " C 6323 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CBr Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It severely injures the lung by acute inhalation. Option B: It is toxic by ingestion and inhalation. Option C: It may be toxic by ingestion and inhalation. Option D: It is mildly toxic by ingestion and inhalation. " A 5073 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been associated with elevations in serum aminotransferase levels and acute, clinically apparent liver injury. Option B: It is associated with frequent elevations in serum aminotransferase levels and with rare instances of clinically apparent acute liver injury. Option C: It is associated with serum aminotransferase elevations and rare instances of clinically apparent acute liver injury. Option D: It has transient elevations in serum aminotransferase levels during therapy and rare instances of clinically apparent acute liver injury. " C 6896 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=C(C(=CC=C1)C)N Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is toxic by inhalation, ingestion, and skin absorption. Option B: It may be toxic by ingestion, inhalation, or skin absorption. Option C: It is toxic by inhalation, ingestion, or skin absorption. Option D: It is toxic by ingestion, inhalation, and skin absorption. " D 24685 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)OC(=O)NC1=CC=CC=C1 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has low mammalian oral and dermal toxicity. Option B: It has relatively low mammalian oral and dermal toxicity. Option C: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. Option D: It has low mammalian toxicity, but there is a slight concern regarding its ability to bioaccumulate. " A 44093 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[C@H](CS)C(=O)N1CCC[C@H]1C(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with a low rate of transient serum aminotransferase elevations and rare instances of clinically apparent acute liver injury. Option B: It has a low rate of transient serum aminotransferase elevations and rare instances of acute liver injury. Option C: It is associated with a low rate of transient serum aminotransferase elevations and with rare instances of clinically apparent acute liver injury. Option D: It is associated with a low rate of transient serum aminotransferase elevations and rare instances of acute liver injury. " D 17581 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC1=CC(=C(C=C1Cl)OC)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has relatively low mammalian oral and dermal toxicity. Option B: It has low mammalian oral and dermal toxicity. Option C: It has low dermal, oral, and inhalation toxicity. Option D: It has relatively low mammalian oral and dermal toxicity, but can still have broad control spectrum. " C 10258 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C(=CN2)OS(=O)(=O)O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to cases of acute liver injury, including acute cholestatic hepatitis and veno-occlusive disease. Option B: It can cause both an acute hepatitis-like syndrome and a more insidious chronic hepatitis with autoimmune features. Option C: It can cause minor transient serum enzyme elevations and has been linked to cases of acute liver injury including cholestatic hepatitis and acute veno-occlusive disease. Option D: It stimulates glomerular sclerosis and interstitial fibrosis as a circulating uremic toxin. " D 5530 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1C(C1N)C2=CC=CC=C2 Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is linked to rare instances of clinically apparent acute liver injury. Option B: It can be associated with rare instances of clinically apparent acute liver injury. Option C: It has been linked to rare instances of clinically apparent acute liver injury. Option D: It is associated with rare instances of clinically apparent acute liver injury. " D 77991 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCN(C)C(=O)OC1=CC=CC(=C1)[C@H](C)N(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is associated with a high rate of transient serum enzyme elevations during treatment and occasional instances of clinically apparent liver injury with jaundice. Option B: It is associated with a minimal rate of serum enzyme elevations during therapy and is a rare cause of clinically apparent liver injury. Option C: It has been associated with serum enzyme elevations during therapy and with rare instances of clinically apparent acute liver injury. Option D: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent acute liver injury with jaundice. " B 6918638 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)/C=C/C(=O)NO Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been reported to cause clinically apparent fatal, acute liver injury. Option B: It can cause clinically apparent acute liver injury. Option C: It can cause clinically apparent, acute liver injury. Option D: It can cause clinically apparent acute drug-induced liver injury. " A 2284 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=CC=C1C(CC(=O)O)CN)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare, but occasionally severe cases of clinically apparent acute liver injury. Option B: It has not been linked to rare instances of mild, self-limited, clinically apparent liver injury. Option C: It has been linked to rare, but occasionally severe cases of acute liver injury. Option D: It is an uncommon, but well established cause of clinically apparent acute liver injury. " B 8343 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: Therapy with this molecule is associated with transient elevations in serum aminotransferase levels and rare instances of clinically apparent acute liver injury, which can be severe and sometimes fatal. Option B: It is associated with transient and asymptomatic elevations in serum aminotransferase levels and is a well-known cause of clinically apparent, acute liver injury that can be severe and even fatal. Option C: It may have toxic effects when there are increased exposures resulting from intravenous fluids delivered through plastic tubing or ingesting contaminated foods or water. Option D: It is associated with mild and transient serum enzyme elevations and with moderate-to-severe clinically apparent liver injury when abused by intravenous administration or the sublingual formations. " C 62781 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C[N+]1(CCCCC1)C.[Cl-] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits high toxicity by inhalation and ingestion. Option B: It exhibits low acute toxicity to various organisms. Option C: It generally has been shown to be of low acute toxicity. Option D: It exhibits toxicity by inhalation, skin absorption, and ingestion. " C 1146 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)C Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has adverse health effects when there is long-term inhalation of low concentrations or short-term inhalation of high concentrations. Option B: It has had limited clinical use and has not been linked to serum enzyme elevations or instances of clinically apparent liver injury with jaundice. Option C: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. Option D: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent acute liver injury with jaundice. " A 3485 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(CC=O)CC=O Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is moderately toxic to mammals, birds, fish, and aquatic invertebrates. Option B: It is not harmful to most aquatic fauna and flora. Option C: It is moderately toxic to humans, mammals, birds and most aquatic organisms. Option D: It is moderately toxic to mammals and fish but poses more of a risk to aquatic invertebrates. " B 3026 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It appears to have relatively low acute (short-term) and chronic (long-term) toxicity. Option B: It has not been linked to rare instances of mild, self-limited, clinically apparent liver injury. Option C: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. Option D: It has not been linked to significant serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. " A 783 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: [HH] Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It is moderately toxic to humans, mammals, birds and most aquatic organisms. Option B: It is toxic to birds, most aquatic organisms, and earthworms. Option C: It can asphyxiate by the displacement of air. Option D: It is not toxic but is a simple asphyxiate by the displacement of oxygen in the air. " D 24386 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: O=S(Cl)Cl Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It exhibits a high level of toxicity. Option B: It exhibits severe muscle toxicity. Option C: It exhibits corrosive toxicity. Option D: It is highly corrosive and toxic. " D 2662 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F Question about this molecule: Which kind of toxicity does this molecule have/exhibit? Option A: It has been linked to rare instances of idiosyncratic drug-induced liver disease. Option B: It has been linked to rare instances of idiosyncratic drug induced liver disease. Option C: It has been linked to rare instances of clinically apparent, idiosyncratic liver injury. Option D: It has been linked to rare instances of clinically apparent, idiosyncratic drug induced liver disease. " A 24085 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: Cl[Hg]Cl Question about this molecule: How is the volatileness of this molecule Option A: It is not very volatile. Option B: It is slightly volatile at ordinary temperatures. Option C: It is not volatile. Option D: It is not considered particularly volatile. " B 10967 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(OCCl)Cl Question about this molecule: How is the volatileness of this molecule Option A: It can be dissolved in water and evaporates quickly. Option B: It will quickly evaporate into the air. Option C: The liquid evaporates quickly when exposed to air. Option D: It readily evaporates into air. " D 6569 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(=O)C Question about this molecule: How is the volatileness of this molecule Option A: The liquid evaporates quickly when exposed to air. Option B: It readily evaporates into air. Option C: It can be dissolved in water and evaporates quickly. Option D: It will quickly evaporate into the air. " D 2256 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCNC1=NC(=NC(=N1)Cl)NC(C)C Question about this molecule: How is the volatileness of this molecule Option A: It is not volatile. Option B: It is not very volatile. Option C: It is not considered particularly volatile. Option D: It is slightly volatile at ordinary temperatures. " B 6184 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCCC=O Question about this molecule: How is the volatileness of this molecule Option A: It appears as a high explosive. Option B: It is a volatile compound. Option C: It is not considered particularly volatile. Option D: It is a volatile organic compound. " B 6359 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(Cl)(Cl)Br Question about this molecule: How is the volatileness of this molecule Option A: It will quickly evaporate into the air. Option B: The liquid evaporates quickly when exposed to air. Option C: It readily evaporates into air. Option D: It can be dissolved in water and evaporates quickly. " C 7997 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCOC(=O)C Question about this molecule: How is the volatileness of this molecule Option A: It evaporates into the air very quickly and dissolves slightly in water. Option B: It can be dissolved in water and evaporates somewhat faster than water. Option C: It evaporates to air and dissolves only slightly in water. Option D: It is less dense than water and its vapors are heavier than air. " D 6568 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCC(C)O Question about this molecule: How is the volatileness of this molecule Option A: It has a flash point below 0 °F. Option B: It does not evaporate easily and is slightly soluble in water. Option C: It evaporates to air and dissolves only slightly in water. Option D: It is likely to generate a considerable amount of vapor at ambient temperatures. " A 15413 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)(C)OC Question about this molecule: How is the volatileness of this molecule Option A: It is a flammable liquid. Option B: It will quickly evaporate into the air. Option C: The liquid evaporates quickly when exposed to air. Option D: It is shipped as a liquid under its vapor pressure. " A 991 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OC1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: How is the volatileness of this molecule Option A: It is not very volatile. Option B: It is not volatile. Option C: It is slightly volatile at ordinary temperatures. Option D: It is not considered particularly volatile. " B 5976 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CN(C)N Question about this molecule: How is the volatileness of this molecule Option A: It evaporates to air and dissolves only slightly in water. Option B: It can be dissolved in water and evaporates somewhat faster than water. Option C: Vapors may travel to a source of ignition. Option D: It can be dissolved in water and evaporates quickly. " C 29393 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCN(CCC)C1=C(C=C(C=C1[N+](=O)[O-])S(=O)(=O)N)[N+](=O)[O-] Question about this molecule: How is the volatileness of this molecule Option A: It is not very volatile. Option B: It is not volatile. Option C: It is not considered particularly volatile. Option D: It is slightly volatile at ordinary temperatures. " B 7865 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: COC=O Question about this molecule: How is the volatileness of this molecule Option A: It can be dissolved in water and evaporates somewhat faster than water. Option B: It evaporates to air and dissolves only slightly in water. Option C: It is less dense than water and its vapors are heavier than air. Option D: It evaporates into the air very quickly and dissolves slightly in water. " C 91756 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOC1=NC(=NC(=N1)NC(=O)NS(=O)(=O)C2=CC=CC=C2C(=O)OC)NC Question about this molecule: How is the volatileness of this molecule Option A: It is not considered particularly volatile. Option B: It is non-volatile. Option C: It is not volatile. Option D: It is nonvolatile. " B 6363 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(C)N Question about this molecule: How is the volatileness of this molecule Option A: It can be dissolved in water and evaporates somewhat faster than water. Option B: It evaporates into the air very quickly and dissolves slightly in water. Option C: It is less dense than water and its vapors are heavier than air. Option D: It evaporates to air and dissolves only slightly in water. " C 1493 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])O Question about this molecule: How is the volatileness of this molecule Option A: It evaporates to air and dissolves only slightly in water. Option B: It does not readily evaporate at room temperature. Option C: It evaporates more slowly than water. Option D: It does not easily evaporate to air. " D 7434 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=C(C=C(C=C1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-] Question about this molecule: How is the volatileness of this molecule Option A: It appears as a high explosive. Option B: It is not considered particularly volatile. Option C: It is a volatile compound. Option D: It is a volatile organic compound. " A 241 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=CC=C1 Question about this molecule: How is the volatileness of this molecule Option A: It can be dissolved in water and evaporates quickly. Option B: It evaporates to air and dissolves only slightly in water. Option C: It can be dissolved in water and evaporates somewhat faster than water. Option D: It evaporates into the air very quickly and dissolves slightly in water. " D 6544 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1=CC(=O)CC(C1)(C)C Question about this molecule: How is the volatileness of this molecule Option A: It evaporates into the air very quickly and dissolves slightly in water. Option B: It evaporates to air and dissolves only slightly in water. Option C: It can be dissolved in water and evaporates somewhat faster than water. Option D: It can be dissolved in water and evaporates quickly. " C 7047 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C2C(=C1)C=CC=N2 Question about this molecule: How is the volatileness of this molecule Option A: It breaks down quickly in the atmosphere and water. Option B: It evaporates to air and dissolves only slightly in water. Option C: It can be dissolved in water and evaporates somewhat faster than water. Option D: It evaporates into the air very quickly and dissolves slightly in water. " A 3562 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(C(F)(F)F)(Cl)Br Question about this molecule: How is the volatileness of this molecule Option A: It is likely to generate a considerable amount of vapor at ambient temperatures. Option B: It has a pleasant odor and does not irritate the airway. Option C: It is a clear, colorless, and highly flammable liquid with a low boiling point and a characteristic odor. Option D: It is a clear colorless highly volatile liquid with a sweet chloroform-like odor. " D 7843 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCC Question about this molecule: How is the volatileness of this molecule Option A: Any leak can be either liquid or vapor. Option B: It can be dissolved in water and evaporates somewhat faster than water. Option C: It evaporates to air and dissolves only slightly in water. Option D: It is less dense than water and its vapors are heavier than air. " A 5971 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CCN=C=S Question about this molecule: How is the volatileness of this molecule Option A: It is not considered particularly volatile. Option B: It is a volatile compound. Option C: It is a volatile organic compound. Option D: It appears as a high explosive. " C 7964 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)Cl Question about this molecule: How is the volatileness of this molecule Option A: It readily evaporates into air. Option B: The liquid evaporates quickly when exposed to air. Option C: It will quickly evaporate into the air. Option D: It can be dissolved in water and evaporates quickly. " A 996 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)O Question about this molecule: How is the volatileness of this molecule Option A: It evaporates more slowly than water. Option B: It evaporates into the air very quickly and dissolves slightly in water. Option C: It evaporates to air and dissolves only slightly in water. Option D: It can be dissolved in water and evaporates somewhat faster than water. " A 213032 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC1(C(=O)N(C(=O)O1)NC2=CC=CC=C2)C3=CC=C(C=C3)OC4=CC=CC=C4 Question about this molecule: How is the volatileness of this molecule Option A: It is not considered particularly volatile. Option B: It is non-volatile. Option C: It is nonvolatile. Option D: It is not volatile. " B 3283 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOCC Question about this molecule: How is the volatileness of this molecule Option A: It has a pleasant odor and does not irritate the airway. Option B: It is likely to generate a considerable amount of vapor at ambient temperatures. Option C: It is a clear, colorless, and highly flammable liquid with a low boiling point and a characteristic odor. Option D: It is a clear colorless highly volatile liquid with a sweet chloroform-like odor. " C 6564 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CC(CCl)Cl Question about this molecule: How is the volatileness of this molecule Option A: It readily evaporates into air. Option B: It will quickly evaporate into the air. Option C: The liquid evaporates quickly when exposed to air. Option D: It can be dissolved in water and evaporates quickly. " A 6337 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCl Question about this molecule: How is the volatileness of this molecule Option A: It can be dissolved in water and evaporates somewhat faster than water. Option B: It evaporates more slowly than water. Option C: It evaporates to air and dissolves only slightly in water. Option D: The liquid evaporates quickly when exposed to air. " D 2871 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCOP(=S)(OCC)OC1=CC2=C(C=C1)C(=C(C(=O)O2)Cl)C Question about this molecule: How is the volatileness of this molecule Option A: It is not volatile. Option B: It is non-volatile. Option C: It is nonvolatile. Option D: It is not considered particularly volatile. " C 7855 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C=CC#N Question about this molecule: How is the volatileness of this molecule Option A: It can be dissolved in water and evaporates somewhat faster than water. Option B: It evaporates to air and dissolves only slightly in water. Option C: It evaporates into the air very quickly and dissolves slightly in water. Option D: It can be dissolved in water and evaporates quickly. " D 5206 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(OC(C(F)(F)F)C(F)(F)F)F Question about this molecule: How is the volatileness of this molecule Option A: It is a clear colorless highly volatile liquid with a sweet chloroform-like odor. Option B: It has a pleasant odor and does not irritate the airway. Option C: It is a clear, colorless, and highly flammable liquid with a low boiling point and a characteristic odor. Option D: It is likely to generate a considerable amount of vapor at ambient temperatures. " B 6327 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCl Question about this molecule: How is the volatileness of this molecule Option A: The liquid evaporates quickly when exposed to air. Option B: It will quickly evaporate into the air. Option C: It is shipped as a liquid under its vapor pressure. Option D: It is a flammable liquid. " C 7416 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)[N+](=O)[O-] Question about this molecule: How is the volatileness of this molecule Option A: It evaporates to air and dissolves only slightly in water. Option B: It evaporates into the air very quickly and dissolves slightly in water. Option C: It can be dissolved in water and evaporates quickly. Option D: It can be dissolved in water and evaporates somewhat faster than water. " A 6115 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C1=CC=C(C=C1)N Question about this molecule: How is the volatileness of this molecule Option A: It evaporates to air and dissolves only slightly in water. Option B: It evaporates more slowly than water. Option C: It does not easily evaporate to air. Option D: It does not readily evaporate at room temperature. " D 12695 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: C(=O)(C(F)(F)F)C(F)(F)F Question about this molecule: How is the volatileness of this molecule Option A: It is likely to generate a considerable amount of vapor at ambient temperatures. Option B: It does not evaporate easily and is slightly soluble in water. Option C: It evaporates to air and dissolves only slightly in water. Option D: It evaporates into the air very quickly and dissolves slightly in water. " A 3026 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options. Molecule SMILES: CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC Question about this molecule: How is the volatileness of this molecule Option A: It evaporates into the air very quickly and dissolves slightly in water. Option B: It can be dissolved in water and evaporates somewhat faster than water. Option C: It evaporates to air and dissolves only slightly in water. Option D: It does not evaporate easily and is slightly soluble in water. " D