CID	Question	Answer
5284627	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(O[C@@H]2CO[C@@]3([C@H]([C@@H]2O1)OC(O3)(C)C)COS(=O)(=O)N)C
Question about this molecule: What is the right information about this molecule's absorption?
Option A: It is absorbed through roots and foliage.
Option B: It is rapidly absorbed through membranes.
Option C: It is quickly absorbed after oral use.
Option D: It is absorbed through the roots and green tissues.
"	C
5983	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@]12CCN([C@@H]1N(C3=C2C=C(C=C3)OC(=O)NC)C)C
Question about this molecule: What is the right information about this molecule's absorption?
Option A: It is easily absorbed through skin.
Option B: It is absorbed through the roots and green tissues.
Option C: It is rapidly absorbed through membranes.
Option D: It is absorbed through roots and foliage.
"	C
6918485	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@H](C1=NC(=CS1)C2=CC=C(C=C2)C#N)[C@](CN3C=NC=N3)(C4=C(C=CC(=C4)F)F)O
Question about this molecule: What is the right information about this molecule's absorption?
Option A: It undergoes very little absorption following oral or topical administration.
Option B: It has good absorption and enhanced oral bioavailability.
Option C: It has excellent absorption and tissue penetration.
Option D: It has minimal oral absorption.
"	B
3152	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC
Question about this molecule: What is the right information about this molecule's absorption?
Option A: It has poor absorption profile, and prodrug and other conjugated compounds have been developed for improved solubility, gastrointestinal absorption, and bioavailability.
Option B: It is well absorbed in the gut with an oral bioavailability of 100% and easily crosses the blood-brain barrier.
Option C: It is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier.
Option D: Its absorption in man is effected over a longer period of time as compared to corticotropin.
"	B
6433272	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1/C=C/C=C/CC/C=C/C=C/C=C/C=C/C(CC2C(C(C[C@](O2)(CC(C(CCC(CC(CC(CC(=O)O[C@H]([C@@H]([C@@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)O[C@@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)O)N)O
Question about this molecule: What is the right information about this molecule's absorption?
Option A: It undergoes very little absorption following oral or topical administration.
Option B: It has good absorption and enhanced oral bioavailability.
Option C: It has excellent absorption and tissue penetration.
Option D: It has minimal oral absorption.
"	A
213031	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(CCCCC1)C(=O)NC2=C(C(=C(C=C2)O)Cl)Cl
Question about this molecule: What is the right information about this molecule's absorption?
Option A: It is absorbed through roots and foliage.
Option B: It is absorbed through foliage and roots and translocated into the plant.
Option C: It is absorbed through the roots and green tissues.
Option D: It is absorbed into the outer waxy layer of plant surfaces.
"	D
16133751	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)[C@@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N3CCC[C@H]3C(=O)O)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC7=CC=CC=C7)NC(=O)[C@H](CC8=CN=CN8)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CC9=CC=C(C=C9)O)NC(=O)[C@H](CO)N
Question about this molecule: What is the right information about this molecule's absorption?
Option A: It is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier.
Option B: It has poor absorption profile, and prodrug and other conjugated compounds have been developed for improved solubility, gastrointestinal absorption, and bioavailability.
Option C: Its absorption in man is effected over a longer period of time as compared to corticotropin.
Option D: It is well absorbed in the gut with an oral bioavailability of 100% and easily crosses the blood-brain barrier.
"	C
27661	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1[C@@H]([C@@H]2[C@H](O1)[C@@H](CO2)O[N+](=O)[O-])O
Question about this molecule: What is the right information about this molecule's absorption?
Option A: Its absorption in man is effected over a longer period of time as compared to corticotropin.
Option B: It has poor absorption profile, and prodrug and other conjugated compounds have been developed for improved solubility, gastrointestinal absorption, and bioavailability.
Option C: It is well absorbed in the gut with an oral bioavailability of 100% and easily crosses the blood-brain barrier.
Option D: It has a slow onset of absorption and metabolism, resulting in a longer duration of action than nitroglycerin.
"	D
36273	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)N=CN3CCCCCC3)C(=O)O)C
Question about this molecule: What is the right information about this molecule's absorption?
Option A: It can be absorbed systemically through inhalation, ingestion, and the skin.
Option B: It is poorly absorbed if given orally and is used in urinary infections and typhus.
Option C: It is rapidly absorbed through the roots of plants with tranlocation acropetally to all plant parts.
Option D: It is absorbed by the roots and works by inhibiting root development and growth.
"	B
6474310	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C(C[C@H](C([C@@H]1OC(=O)/C=C/C2=CC(=C(C=C2)O)O)O)OC(=O)/C=C/C3=CC(=C(C=C3)O)O)(O)C(=O)O
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It exhibits antiplasmodial and antitrypanosomal activities.
Option B: It selectively inhibits mitosis and cell division.
Option C: It inhibits cell-wall biosynthesis.
Option D: It exhibits hepatoprotective and cytotoxic activities.
"	D
10072444	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(=O)C1=C(C=C(C(=C1OC)C2=C3C(=C(C=C2CO)O)C(=O)C4=C(C3=O)C=CC=C4O)O)O
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It inhibits cell-wall biosynthesis.
Option B: It selectively inhibits mitosis and cell division.
Option C: It suppresses inflammation and stimulates cell-mediated immunity.
Option D: It exhibits antiplasmodial and antitrypanosomal activities.
"	D
5289501	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C/C(=C\\C1=CC=C(C=C1)C(=O)O)/C2=CC3=C(C=C2)C(CCC3(C)C)(C)C
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It acts as a selective agonist for the retinoic acid receptors (RAR).
Option B: It acts as an agonist to the GABA receptors.
Option C: It acts upon the nicotinic acetylcholine receptors.
Option D: It acts as a selective antagonist of the muscarinic acetylcholine receptors.
"	A
10089677	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CN=C(C2=C1NC(=N2)N)C3=CC(=C(N3)Br)Br
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It acts as an inhibitor of the matrix metalloproteinases.
Option B: It is an inhibitor of carbonic anhydrase, particularly subtypes II and IV.
Option C: It is an anti-arrhythmia drug and a sodium channel blocker.
Option D: It is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE).
"	A
48041	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CCCCC1CCC2=CC=CC=C2NC(=O)C3=CC=C(C=C3)OC
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It acts as an L-type calcium channel blocker.
Option B: It is an anti-arrhythmia drug and a sodium channel blocker.
Option C: It acts as an anti-inflammatory agent and antibiotic.
Option D: It is a calcium-channel blocker and vasodilator.
"	B
3034285	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CO/C=C(\\C1=CC=CC=C1OC2=NC=NC(=C2)OC3=CC=CC=C3C#N)/C(=O)OC
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It is an inhibitor of mitochondrial respiration by blocking electron transfer between cytochromes b and c1.
Option B: It exhibits the action of acting as an inhibitor of cholinesterase and being highly toxic by all routes of exposure.
Option C: It is used for the prevention and management of angina pectoris caused by coronary artery disease, but its onset of action is not rapid enough to offset an acute anginal episode.
Option D: It exhibits the actions of being an extremely potent uncoupler of oxidative phosphorylation in mitochondria and having high reactivity with thiols.
"	A
60210132	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCN(CCC)C[C@H]1CCCCN1CCNC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It inhibits acetylcholinesterase.
Option B: It acts upon the nicotinic acetylcholine receptors.
Option C: It binds irreversibly to acetylcholinesterase.
Option D: It acts as a selective antagonist of the muscarinic acetylcholine receptors.
"	D
5284330	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CNC1CCC(CC1)N(CC2=CC(=CC=C2)C3=CC=NC=C3)C(=O)C4=C(C5=CC=CC=C5S4)Cl
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It mediates a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis.
Option B: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter.
Option C: It antagonizes cyclopamine action at the Smo receptor and activates the Hedgehog signaling pathway in a Patched independent manner.
Option D: It antagonizes the strychnine-insensitive glycine site of the NMDA receptor and prevents neurodegeneration produced by quinolinic acid.
"	C
3002977	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=NN=C(N1C2C[C@H]3CC[C@@H](C2)N3CC[C@@H](C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F)C(C)C
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It acts as an excitotoxin on glutamate receptors such as NMDA, calcium dependent AMPA and kainite receptors.
Option B: It prevents the interaction of HIV-1 gp120 and chemokine receptor 5 (CCR5) necessary for CCR5-tropic HIV-1 to enter cells.
Option C: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter.
Option D: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.
"	B
3408722	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCCN1CCCC1CNC(=O)C2=C(C3=CC=CC=C3C(=C2)C#N)OC
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It exhibits the action of acting as an inhibitor of cholinesterase and being highly toxic by all routes of exposure.
Option B: It exhibits the action of having a delayed onset, narrow therapeutic window, need for regular monitoring and INR testing, and numerous drug-drug and drug-food interactions, which limits its effective use for stroke prevention.
Option C: It exhibits the actions of being an extremely potent uncoupler of oxidative phosphorylation in mitochondria and having high reactivity with thiols.
Option D: It is a highly potent, competitive, preferential dopamine D3 receptor antagonist, centrally active upon systemic administration.
"	D
145343771	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CCC(CC1)C[C@@H](C(=O)N[C@@H](C[C@@H]2CCNC2=O)C=O)NC(=O)C3=CC4=CC=CC=C4N3
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It is an inhibitor of SARS coronavirus main proteinase and inhibits SARS-CoV-2 replication in cell culture.
Option B: It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties.
Option C: It inhibits the increase in promoter activity observed following overexpression of PKCdelta, constitutively active Ras, or MEKK1.
Option D: It prevents the interaction of HIV-1 gp120 and chemokine receptor 5 (CCR5) necessary for CCR5-tropic HIV-1 to enter cells.
"	A
16124774	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC=CC=C1NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter.
Option B: It acts as a potent and ATP-competitive inhibitor of VEGFR2/KDR, Flt3, and cKit.
Option C: It mediates a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis.
Option D: It inhibits the increase in promoter activity observed following overexpression of PKCdelta, constitutively active Ras, or MEKK1.
"	B
4763	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC1(C(=O)NC(=O)NC1=O)C2=CC=CC=C2
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter.
Option B: It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors and modulates chloride currents through receptor channels.
Option C: It inhibits the increase in promoter activity observed following overexpression of PKCdelta, constitutively active Ras, or MEKK1.
Option D: It mediates a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis.
"	B
50942	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC3OCCO3
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It acts as an excitotoxin on glutamate receptors such as NMDA, calcium dependent AMPA and kainite receptors.
Option B: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter.
Option C: It does not affect calcium influx and does not antagonize the actions of calcium channel blockers.
Option D: It exhibits the actions of closing N-type voltage-operated calcium channels (OP2-receptor agonist) and opening calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist).
"	C
5284627	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(O[C@@H]2CO[C@@]3([C@H]([C@@H]2O1)OC(O3)(C)C)COS(=O)(=O)N)C
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE).
Option B: It is an inhibitor of carbonic anhydrase, particularly subtypes II and IV.
Option C: It is an anti-arrhythmia drug and a sodium channel blocker.
Option D: It acts as an inhibitor of the matrix metalloproteinases.
"	B
55283	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@H]5CO[C@](O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It acts as an excitotoxin on glutamate receptors such as NMDA, calcium dependent AMPA and kainite receptors.
Option B: It antagonizes the strychnine-insensitive glycine site of the NMDA receptor and prevents neurodegeneration produced by quinolinic acid.
Option C: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter.
Option D: It interacts with 14-alpha demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol.
"	D
71482	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COP(=O)(OC)SCN1C2=C(C=C(C=N2)Cl)OC1=O
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It acts by inhibition of cholinesterase activity.
Option B: It inhibits cholinesterase enzyme.
Option C: It acts as an inhibitor of cholinesterase.
Option D: It inhibits acetylcholinesterase.
"	A
41368	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)(C)C(C(N1C=NC=N1)OC2=CC=C(C=C2)Cl)O
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It has curative, protective, and eradicant action.
Option B: It has systemic protective and curative action.
Option C: It has systemic protective, curative, and eradicant action.
Option D: It is very irritating to skin and mucous membranes and has keratolytic actions.
"	A
6918485	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@H](C1=NC(=CS1)C2=CC=C(C=C2)C#N)[C@](CN3C=NC=N3)(C4=C(C=CC(=C4)F)F)O
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain.
Option B: It undergoes biotransformation to form the active moiety for antifungal actions.
Option C: Its supplements have been banned by the FDA because of their high toxicity.
Option D: It is commonly associated with serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury.
"	B
9046	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=C3C=CC(=C4)OC5CCCC5
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It interacts with the estrogen receptor.
Option B: It first acts on the mu-opioid receptors.
Option C: It interacts predominantly with the opioid mu-receptors.
Option D: It activates opioid receptors in the intestine.
"	A
446596	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]([C@H]1[C@@H](O1)C[C@H]2CO[C@H]([C@@H]([C@@H]2O)O)C/C(=C/C(=O)OCCCCCCCCC(=O)O)/C)[C@H](C)O
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It inhibits microbial cellular protein synthesis.
Option B: It inhibits DNA synthesis.
Option C: It inhibits bacterial protein synthesis.
Option D: It interferes with bacterial protein synthesis.
"	C
3478	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CN=C(C=N1)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It displays rapid absorption and onset of action with the shortest half-life and duration of action.
Option B: It has a rapid onset of action and short half-life.
Option C: It works quickly and has a short half-life.
Option D: It has a fast onset of action.
"	A
2099	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(N=CN1)CN2CCC3=C(C2=O)C4=CC=CC=C4N3C
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It does not interact with GABA receptors.
Option B: It first acts on the mu-opioid receptors.
Option C: It has an antagonist action on the 5-HT3 receptors.
Option D: It interacts predominantly with the opioid mu-receptors.
"	C
135398735	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1/C=C/C=C(\\C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)[C@](O4)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)/C=N/N5CCN(CC5)C)/C
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It can inhibit phosphodiesterases and may have direct actions on calcium channels.
Option B: It has direct actions on blood vessels and increases cardiac output.
Option C: It can act on both N-type and L-type calcium channels.
Option D: It acts on both intracellular and extracellular organisms.
"	D
135398745	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC2=C(S1)NC3=CC=CC=C3N=C2N4CCN(CC4)C
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It exhibits the action of having a reduced propensity for involvement in drug-drug interactions owing to its primarily reductive metabolism.
Option B: It has less risk of drug-drug interactions compared to certain other drugs.
Option C: It exhibits the action of having a delayed onset, narrow therapeutic window, need for regular monitoring and INR testing, and numerous drug-drug and drug-food interactions, which limits its effective use for stroke prevention.
Option D: It has reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug interactions.
"	D
5281855	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=C2C3=C(C(=C1O)O)OC(=O)C4=CC(=C(C(=C43)OC2=O)O)O
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It has antioxidant and anti-proliferative effects.
Option B: It acts as an anti-inflammatory agent and antibiotic.
Option C: It exhibits anti-cancer and cardioprotective properties as an inhibitor of bromodomain-containing protein 4.
Option D: It exhibits antiplasmodial and antitrypanosomal activities.
"	A
2913	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CCC(=C2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It has direct actions on blood vessels and increases cardiac output.
Option B: It causes relaxation of smooth muscle in blood vessels and the prostate.
Option C: It competes with AAA for absorption into the brain.
Option D: It competes with serotonin at receptor sites in smooth muscle.
"	D
39385	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)(C)C(=O)C(N1C=NC=N1)OC2=CC=C(C=C2)Cl
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It has systemic protective, curative, and eradicant action.
Option B: It has systemic protective and curative action.
Option C: It is very irritating to skin and mucous membranes and has keratolytic actions.
Option D: It has curative, protective, and eradicant action.
"	A
4158	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC(=O)C(C1CCCCN1)C2=CC=CC=C2
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It has dopaminergic effects.
Option B: It can increase and sustain plasma levodopa concentrations.
Option C: It appears to block dopamine uptake.
Option D: It has direct actions on blood vessels and increases cardiac output.
"	A
5360696	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CC[C@@]23CCCC[C@@H]2[C@@H]1CC4=C3C=C(C=C4)OC
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It is a noncompetitive NMDA receptor antagonist.
Option B: It is an uncompetitive N-methyl-D-aspartate receptor antagonist and Sigma-1 agonist.
Option C: It is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE).
Option D: It is a highly potent, competitive, preferential dopamine D3 receptor antagonist, centrally active upon systemic administration.
"	B
27661	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1[C@@H]([C@@H]2[C@H](O1)[C@@H](CO2)O[N+](=O)[O-])O
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It exhibits the action of having a delayed onset, narrow therapeutic window, need for regular monitoring and INR testing, and numerous drug-drug and drug-food interactions, which limits its effective use for stroke prevention.
Option B: It is used for the prevention and management of angina pectoris caused by coronary artery disease, but its onset of action is not rapid enough to offset an acute anginal episode.
Option C: It exhibits the actions of being an extremely potent uncoupler of oxidative phosphorylation in mitochondria and having high reactivity with thiols.
Option D: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter.
"	B
5281718	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O)O
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.
Option B: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter.
Option C: It mediates a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis.
Option D: It has multiple actions, including activating GABA(B) receptors, enhancing NMDA current, blocking AMPA-receptor-mediated transmission, binding to the L-alpha-amino acid transporter, activating ATP-sensitive K(+) channels, activating hyperpolarization-activated cation channels, and modulating Ca(2+) current.
"	C
5533	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CN(CCN1CCCN2C(=O)N3C=CC=CC3=N2)C4=CC(=CC=C4)Cl
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It is a highly potent, competitive, preferential dopamine D3 receptor antagonist, centrally active upon systemic administration.
Option B: It has the potential for interaction with adrenergic and serotonergic agents.
Option C: It competes with serotonin at receptor sites in smooth muscle.
Option D: It acts on various receptors, including certain histamine, serotonin, and adrenergic receptors.
"	D
177990	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCCN(CC)C1=NC(=NC2=C1C(=C(N2C3=C(C=C(C=C3C)C)C)C)C)C
Question about this molecule: Which kind of affinity does this molecule have/exhibit?
Option A: It has moderate affinity for histamine and alpha adrenergic receptors, and no appreciable affinity for cholinergic muscarinic receptors.
Option B: It has a high affinity for the mu-opioid receptor, but lower intrinsic activity compared to other full mu-opioid agonists.
Option C: It is an antagonist of corticotropin-releasing factor 1 (CRF-1) receptors with a Ki of 1 nM.
Option D: It has a higher affinity to AR and no partial agonist activity compared to bicalutamide.
"	C
68186	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCCOC4=CC=C(C=C4)F
Question about this molecule: Which kind of affinity does this molecule have/exhibit?
Option A: It has a high affinity for the mu-opioid receptor, but lower intrinsic activity compared to other full mu-opioid agonists.
Option B: It is an antagonist of corticotropin-releasing factor 1 (CRF-1) receptors with a Ki of 1 nM.
Option C: It is a high affinity D2 receptor antagonist with a Ki of 3 nM.
Option D: It has a higher affinity to AR and no partial agonist activity compared to bicalutamide.
"	C
135398737	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Question about this molecule: Which kind of affinity does this molecule have/exhibit?
Option A: It has moderate affinity for histamine and alpha adrenergic receptors, and no appreciable affinity for cholinergic muscarinic receptors.
Option B: It has strong affinity to several dopaminergic receptors, but weak antagonism at the dopamine D2 receptor.
Option C: It has a high affinity for the mu-opioid receptor, but lower intrinsic activity compared to other full mu-opioid agonists.
Option D: It has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors.
"	B
5288783	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H](/C=C/[C@H](C1CC1)O)[C@H]2CC[C@@H]\\3[C@@]2(CCC/C3=C\\C=C/4\\C[C@H](C[C@@H](C4=C)O)O)C
Question about this molecule: Which kind of affinity does this molecule have/exhibit?
Option A: It has a high affinity for μ-opioid receptors.
Option B: It has low to moderate-affinity for NMDA receptors.
Option C: It has comparable affinity with calcitriol for the Vitamin D receptor.
Option D: It has no significant affinity at GABA receptors.
"	C
10324367	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1([C@@H]2[C@H]1[C@H](N(C2)C(=O)[C@H](C(C)(C)C)NC(=O)NC(C)(C)C)C(=O)NC(CC3CCC3)C(=O)C(=O)N)C
Question about this molecule: Which kind of affinity does this molecule have/exhibit?
Option A: It has moderate affinity for histamine and alpha adrenergic receptors, and no appreciable affinity for cholinergic muscarinic receptors.
Option B: It has a high affinity for the mu-opioid receptor, but lower intrinsic activity compared to other full mu-opioid agonists.
Option C: It can alter the affinity of the drug for NS3/4A or the activity of the enzyme itself.
Option D: It has a higher affinity to AR and no partial agonist activity compared to bicalutamide.
"	C
1318	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1
Question about this molecule: Which kind of affinity does this molecule have/exhibit?
Option A: It targets mainly zinc metallopeptidases, with a much lower affinity for calcium metallopeptidases.
Option B: It has a higher affinity to AR and no partial agonist activity compared to bicalutamide.
Option C: It has a high affinity for the mu-opioid receptor, but lower intrinsic activity compared to other full mu-opioid agonists.
Option D: It has moderate affinity for histamine and alpha adrenergic receptors, and no appreciable affinity for cholinergic muscarinic receptors.
"	A
15951529	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(C(=O)N(C(=S)N1C2=CC(=C(C=C2)C(=O)NC)F)C3=CC(=C(C=C3)C#N)C(F)(F)F)C
Question about this molecule: Which kind of affinity does this molecule have/exhibit?
Option A: It has moderate affinity for histamine and alpha adrenergic receptors, and no appreciable affinity for cholinergic muscarinic receptors.
Option B: It has a high affinity for the mu-opioid receptor, but lower intrinsic activity compared to other full mu-opioid agonists.
Option C: It is an antagonist of corticotropin-releasing factor 1 (CRF-1) receptors with a Ki of 1 nM.
Option D: It has a higher affinity to AR and no partial agonist activity compared to bicalutamide.
"	D
60795	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CC(=O)NC2=C1C=CC(=C2)OCCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl
Question about this molecule: Which kind of affinity does this molecule have/exhibit?
Option A: It has moderate affinity for histamine and alpha adrenergic receptors, and no appreciable affinity for cholinergic muscarinic receptors.
Option B: It has a high affinity for the mu-opioid receptor, but lower intrinsic activity compared to other full mu-opioid agonists.
Option C: It has a higher affinity to AR and no partial agonist activity compared to bicalutamide.
Option D: It is an antagonist of corticotropin-releasing factor 1 (CRF-1) receptors with a Ki of 1 nM.
"	A
3378093	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)N4CCC5=CC6=C(C=C54)C7(CCN(CC7)C)CO6
Question about this molecule: Which kind of affinity does this molecule have/exhibit?
Option A: It has a high affinity for human 5-HT1B receptors.
Option B: It has comparable affinity with calcitriol for the Vitamin D receptor.
Option C: It has no significant affinity at GABA receptors.
Option D: It has low to moderate-affinity for NMDA receptors.
"	A
6005	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CCC2=C3[C@H]1CC4=C(C3=CC=C2)C(=C(C=C4)O)O
Question about this molecule: Which kind of agonist activity does this molecule have/exhibit?
Option A: It is a potent agonist of the aryl hydrocarbon receptor.
Option B: It is a very potent NMDA-receptor agonist.
Option C: It possesses potent agonist activity on dopamine D2 receptors.
Option D: It is a dopamine D2 agonist.
"	D
15951529	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(C(=O)N(C(=S)N1C2=CC(=C(C=C2)C(=O)NC)F)C3=CC(=C(C=C3)C#N)C(F)(F)F)C
Question about this molecule: Which kind of agonist activity does this molecule have/exhibit?
Option A: It has no partial agonist activity compared to bicalutamide.
Option B: It acts as an agonist at α2 adrenoceptors.
Option C: It is a potent agonist of the aryl hydrocarbon receptor.
Option D: It is a very potent NMDA-receptor agonist.
"	A
2216	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CN=C(N1)NC2=C(C=C(C=C2Cl)N)Cl
Question about this molecule: Which kind of agonist activity does this molecule have/exhibit?
Option A: It is an alpha-1 Adrenergic Agonist.
Option B: It is an alpha-Adrenergic Agonist.
Option C: It acts as an agonist at α2 adrenoceptors.
Option D: It is a potent agonist of the aryl hydrocarbon receptor.
"	B
70697848	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]([C@@]1(C(=O)N[C@@](C(=O)N1)(CC2=CNC3=CC=CC=C32)OC)SC)O
Question about this molecule: Which kind of antibacterial activity does this molecule have/exhibit?
Option A: It has more activity against both gram-negative and gram-positive bacteria.
Option B: It exhibits antibacterial activity against Staphylococcus aureus.
Option C: It exhibits antibacterial activity against bacterial vaginosis and candidiasis.
Option D: It exhibits potent antibacterial activity against several Gram-positive bacterial strains.
"	B
400452	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C2C(=C1)C(=CN2)C(=O)C3=NC=C(N3)C4=CNC5=C4C=CC(=C5)Br
Question about this molecule: Which kind of antibacterial activity does this molecule have/exhibit?
Option A: It exhibits antibacterial properties.
Option B: It is a broad spectrum antibacterial drug.
Option C: It is a synthetic antibacterial.
Option D: It exhibits potent antibacterial activity.
"	A
4421	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCN1C=C(C(=O)C2=C1N=C(C=C2)C)C(=O)O
Question about this molecule: Which kind of antibacterial activity does this molecule have/exhibit?
Option A: It is effective against many Gram-positive bacteria.
Option B: It exhibits activity against Gram-positive bacteria.
Option C: It exhibits antibacterial activity against Gram-negative bacteria.
Option D: It is more effective against certain Gram-negative bacteria.
"	C
5747698	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@H]1[C@H](CC[C@@H](O1)O[C@@H]2C(=O)C(=C([C@@]3([C@]2(CC4=C(C5=C(C(=O)C=C(C5=O)OC)C(=C4C3=O)O)C)O)O)O)C(=O)C)O[C@H]6C[C@@]([C@@H]([C@@H](O6)C)OC(=O)C7=C(C=CC(=C7O)C)C)(C)O
Question about this molecule: Which kind of antibacterial activity does this molecule have/exhibit?
Option A: It exhibits antibacterial activity against bacterial vaginosis and candidiasis.
Option B: It exhibits antibacterial activity against Staphylococcus aureus.
Option C: It has more activity against both gram-negative and gram-positive bacteria.
Option D: It exhibits potent antibacterial activity against several Gram-positive bacterial strains.
"	D
4831	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCN1C=C(C(=O)C2=CN=C(N=C21)N3CCNCC3)C(=O)O
Question about this molecule: Which kind of antibacterial activity does this molecule have/exhibit?
Option A: It is a broad spectrum antibacterial drug.
Option B: It is a synthetic broad-spectrum antibacterial.
Option C: It has broad-spectrum antibacterial activity.
Option D: It has a wide spectrum of antibacterial activity.
"	B
4855	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCN1C=C(C(=O)C2=CN=C(N=C21)N3CCCC3)C(=O)O
Question about this molecule: Which kind of antibacterial activity does this molecule have/exhibit?
Option A: It exhibits antibacterial properties.
Option B: It is a synthetic broad-spectrum antibacterial.
Option C: It is a synthetic antibacterial.
Option D: It is a broad spectrum antibacterial drug.
"	C
16134627	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)CCCCCCCCC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1OC2=C3C=C4C=C2OC5=C(C=C(C=C5)[C@H]([C@H]6C(=O)N[C@@H](C7=C(C(=CC(=C7)O)O[C@@H]8[C@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)C9=C(C=CC(=C9)[C@H](C(=O)N6)NC(=O)[C@@H]4NC(=O)[C@@H]1C2=C(C(=CC(=C2)OC2=C(C=CC(=C2)[C@H](C(=O)N[C@H](CC2=CC=C(O3)C=C2)C(=O)N1)NC)O)O)Cl)O)C(=O)NCCCN(C)C)O)Cl)C(=O)O)O)O
Question about this molecule: Which kind of antibacterial activity does this molecule have/exhibit?
Option A: It is used for the treatment of acute bacterial skin and skin structure infections.
Option B: It exhibits potent antibacterial activity against several Gram-positive bacterial strains.
Option C: It exhibits antibacterial activity against Staphylococcus aureus.
Option D: It exhibits antibacterial activity against bacterial vaginosis and candidiasis.
"	A
149096	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
Question about this molecule: Which kind of antibacterial activity does this molecule have/exhibit?
Option A: It has more activity against both gram-negative and gram-positive bacteria.
Option B: It exhibits antibacterial activity against bacterial vaginosis and candidiasis.
Option C: It exhibits antibacterial activity against Staphylococcus aureus.
Option D: It exhibits potent antibacterial activity against several Gram-positive bacterial strains.
"	A
5479537	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[N+]1(CCCC1)CC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\\OC)/C4=CSC(=N4)N)SC2)C(=O)[O-]
Question about this molecule: Which kind of antibacterial activity does this molecule have/exhibit?
Option A: It is effective against both Gram-negative and Gram-positive organisms.
Option B: It is more effective against certain Gram-negative bacteria.
Option C: It is active against both Gram-positive and Gram-negative bacteria.
Option D: It is effective against many Gram-positive bacteria.
"	C
70680263	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CCC[C@]2([C@H]1CC3=C(C2=O)OC=C3C)C
Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit?
Option A: It shows high antifungal activity against diseases caused by various pathogens.
Option B: It shows antifungal activity towards the pathogenic yeast Candida albicans.
Option C: It shows antifungal activity against various human and phytophathogenic fungi.
Option D: It exhibits antifungal activity against plant pathogenic fungi.
"	C
9806019	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC2=C(C(=C1)Cl)SC=C2CO[C@@H](CN3C=CN=C3)C4=C(C=C(C=C4)Cl)Cl.[N+](=O)(O)[O-]
Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit?
Option A: It is used as a broad-spectrum antifungal drug.
Option B: It acts as an antifungal and protein synthesis inhibitor.
Option C: It has a role as an antifungal agrochemical.
Option D: It is a broad spectrum antifungal agent.
"	A
45480172	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=O)N(C(=C1)C2CCCCC2)[O-].C(CO)[NH3+]
Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit?
Option A: It acts as an antifungal and protein synthesis inhibitor.
Option B: It has a role as an antifungal agrochemical.
Option C: It is used as a broad-spectrum antifungal drug.
Option D: It is a broad spectrum antifungal agent.
"	D
6604451	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC2=C(C(=C1)Cl)SC=C2CO[C@@H](CN3C=CN=C3)C4=C(C=C(C=C4)Cl)Cl
Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit?
Option A: It is used as a broad-spectrum antifungal drug.
Option B: It acts as an antifungal and protein synthesis inhibitor.
Option C: It has a role as an antifungal agrochemical.
Option D: It is a broad spectrum antifungal agent.
"	A
44151818	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC1=CC=CC=C1N\\2CCS/C2=C(/C#N)\\SC3=C(C=CC(=C3)C(F)(F)F)F
Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit?
Option A: It is used as a broad-spectrum antifungal drug.
Option B: It has a role as an antifungal agrochemical.
Option C: It acts as an antifungal and protein synthesis inhibitor.
Option D: It is a broad spectrum antifungal agent.
"	B
8606	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C=CCC2C1C(=O)N(C2=O)SC(Cl)(Cl)Cl
Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit?
Option A: It is used as a broad-spectrum antifungal drug.
Option B: It has a role as an antifungal agrochemical.
Option C: It is a broad spectrum antifungal agent.
Option D: It acts as an antifungal and protein synthesis inhibitor.
"	B
467825	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@H](C1=NC(=CS1)C2=CC=C(C=C2)C#N)[C@](CN3C=NC=N3)(C4=C(C=C(C=C4)F)F)O
Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit?
Option A: It shows antifungal activity towards the pathogenic yeast Candida albicans.
Option B: It exhibits antifungal activity against plant pathogenic fungi.
Option C: It exhibits antifungal activity by inhibition of 14alpha demethylase.
Option D: It shows antifungal activity against various human and phytophathogenic fungi.
"	C
3034285	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CO/C=C(\\C1=CC=CC=C1OC2=NC=NC(=C2)OC3=CC=CC=C3C#N)/C(=O)OC
Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit?
Option A: It exhibits antifungal activity against fluconazole-resistant yeast Candida glabrata.
Option B: It is a mitochondrial cytochrome-bc1 complex inhibitor.
Option C: It is a mitochondrial cytochrome-bc1 complex inhibitor and an antifungal agrochemical.
Option D: It shows antifungal activity towards the pathogenic yeast Candida albicans.
"	B
53241505	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)(C)C1=CC=C(C=C1)/C(=C\\C(=O)N2CCOCC2)/C3=CN=C(C=C3)Cl
Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit?
Option A: It exhibits antifungal activity against plant pathogenic fungi.
Option B: It shows antifungal activity against various human and phytophathogenic fungi.
Option C: It shows high antifungal activity against diseases caused by various pathogens.
Option D: It shows antifungal activity towards the pathogenic yeast Candida albicans.
"	C
442403	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C[C@@H]2[C@](CC1)([C@]3([C@@H](C[C@H]([C@]34CO4)O2)OC(=O)C)C)C
Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit?
Option A: It is used as a broad-spectrum antifungal drug.
Option B: It has a role as an antifungal agrochemical.
Option C: It acts as an antifungal and protein synthesis inhibitor.
Option D: It is a broad spectrum antifungal agent.
"	C
6918485	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@H](C1=NC(=CS1)C2=CC=C(C=C2)C#N)[C@](CN3C=NC=N3)(C4=C(C=CC(=C4)F)F)O
Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit?
Option A: It has broad-spectrum fungicidal and fungistatic activity against a number of yeasts and fungi, most notably Candida species.
Option B: It exhibits antifungal activity against most of the Candida species, most Aspergillus species, Mucorales, Cryptococcus spp., Fusarium species, dermatophytes, and dimorphic fungi.
Option C: It exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus.
Option D: It is used for the control of soil, root and leaf diseases caused by oomycetes, particularly Phytophthora and Pythium species.
"	B
6433272	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1/C=C/C=C/CC/C=C/C=C/C=C/C=C/C(CC2C(C(C[C@](O2)(CC(C(CCC(CC(CC(CC(=O)O[C@H]([C@@H]([C@@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)O[C@@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)O)N)O
Question about this molecule: Which kind of antifungal activity does this molecule have/exhibit?
Option A: It has broad-spectrum fungicidal and fungistatic activity against a number of yeasts and fungi, most notably Candida species.
Option B: It displays potent broad-spectrum in vitro activity against dermatophytes, filamentous fungi and yeasts.
Option C: It shows antifungal activity against various human and phytophathogenic fungi.
Option D: It induces oxidative stress in yeast and filamentous fungi.
"	A
134131607	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@]1(C[C@H]([C@@]2(C[C@H](C(=O)O2)O)C3=C1C4=C(C(=CC(=C4)OC)O)C(=O)O3)OC)O
Question about this molecule: Which kind of antimicrobial activity does this molecule have/exhibit?
Option A: It has activity against Gram-positive cocci and rods, Gram-negative cocci, Legionellae, mycoplasmas, chlamydiae, some types of spirochetes, Toxoplasma gondii, and Cryptosporidium.
Option B: It is effective against many coliforms, including Escherichia coli, Klebsiella, Enterobacter, and Proteus, and most strains of Salmonella, Shigella, Hemophilus, Citrobacter, and Arizona species.
Option C: It is active against Agrobacterium tumefaciens, Bacillus subtilis, Pseudomonas lachrymans, Ralstonia solanacearum, Staphylococcus hemolyticus, and Xanthomonas vesicatoria.
Option D: It has excellent activity against most aerobic gram-negative bacilli from the Enterobacteriaceae family, including Nocardia and some Mycobacterium.
"	C
43708	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN(C)CCN1C(=NN=N1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)CC4=CSC(=N4)N)SC2)C(=O)O
Question about this molecule: Which kind of antimicrobial activity does this molecule have/exhibit?
Option A: It has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.
Option B: It is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms.
Option C: It is active against a broad spectrum of aerobic and anaerobic Gram-positive and Gram-negative microorganisms.
Option D: It has in vitro activity against aerobic Gram-positive bacteria, certain Gram-negative bacteria, and anaerobic microorganisms.
"	A
6440717	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@H]1C/C=C/C=C/[C@@H]([C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)O)OC)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)O)(C)O)N(C)C)O)CC=O)C)O[C@H]4CC[C@@H]([C@@H](O4)C)N(C)C
Question about this molecule: Which kind of antimicrobial activity does this molecule have/exhibit?
Option A: It has excellent activity against most aerobic gram-negative bacilli from the Enterobacteriaceae family, including Nocardia and some Mycobacterium.
Option B: It is active against Agrobacterium tumefaciens, Bacillus subtilis, Pseudomonas lachrymans, Ralstonia solanacearum, Staphylococcus hemolyticus, and Xanthomonas vesicatoria.
Option C: It is effective against many coliforms, including Escherichia coli, Klebsiella, Enterobacter, and Proteus, and most strains of Salmonella, Shigella, Hemophilus, Citrobacter, and Arizona species.
Option D: It has activity against Gram-positive cocci and rods, Gram-negative cocci, Legionellae, mycoplasmas, chlamydiae, some types of spirochetes, Toxoplasma gondii, and Cryptosporidium.
"	D
29029	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC[C@@H]1C[C@H](N(C1)C)C(=O)NC([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)C(C)Cl
Question about this molecule: Which kind of antimicrobial activity does this molecule have/exhibit?
Option A: It may be bacteriostatic or bactericidal depending on the organism and drug concentration.
Option B: It has excellent activity against most aerobic gram-negative bacilli from the Enterobacteriaceae family, including Nocardia and some Mycobacterium.
Option C: It is active against a wide range of micro-organisms including some fungi and viruses, but is only slowly effective against spores.
Option D: It is active against a broad spectrum of bacteria, fungi, moulds, and viruses.
"	A
12118082	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCCCC(=O)[C@@H]1[C@H]2CC3=C(COC(=C3)/C=C/C)C(=O)[C@@]2(OC1=O)C
Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit?
Option A: It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the vaccinia VIRUS and varicella zoster virus.
Option B: It selectively inhibits survivin (BIRC5) gene promoter activity and down-regulates survivin in vitro, leading to induction of apoptosis.
Option C: It has potent anti-leukemic effects, inducing apoptosis in myeloid leukemia cell lines and primary AML cells at nanomolar concentrations.
Option D: It is a potent inhibitor of carcinogenesis measured against chemical- or UV-initiated, phorbol-promoted mouse skin tumours.
"	D
47751	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=NC(=NC(=O)N1[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)O)N
Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit?
Option A: It inhibits tumor formation and growth by inhibiting LDH.
Option B: It shows good activity against a variety of transplanted tumors.
Option C: It specifically inhibits growth of renal cells in culture.
Option D: It inhibits the growth of Ehrlich ascites carcinoma in vitro.
"	B
4122	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CS3
Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit?
Option A: It induces cell cycle arrest and apoptosis in several human cancer cell lines.
Option B: It exerts its effect by depolymerising microtubules.
Option C: It modulates the lipid content of cancer cell membranes and induces cell cycle arrest and apoptosis in several cancer cell lines.
Option D: It acts to stabilize microtubules, preventing mitosis and causing growth arrest in cancer cells.
"	B
53355590	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H](/C=C/[C@H](C)C(C)C)[C@H]1CCC2=C3C=CC4=CC(=O)CC[C@@]4([C@]3([C@@H](C[C@]12C)O)O)C
Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit?
Option A: It shows good activity against a variety of transplanted tumors.
Option B: It exhibits inhibitory activity against breast cancer resistance protein.
Option C: It exhibits activity against colon adinocarcinoma cells.
Option D: It exhibits inhibitory efficacy against the growth of human tumour cells.
"	C
11178236	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4.[Br-]
Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit?
Option A: It is a potent inhibitor of carcinogenesis measured against chemical- or UV-initiated, phorbol-promoted mouse skin tumours.
Option B: It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the vaccinia VIRUS and varicella zoster virus.
Option C: It selectively inhibits survivin (BIRC5) gene promoter activity and down-regulates survivin in vitro, leading to induction of apoptosis.
Option D: It has potent anti-leukemic effects, inducing apoptosis in myeloid leukemia cell lines and primary AML cells at nanomolar concentrations.
"	C
11485656	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N
Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit?
Option A: It is designed to suppress tumor growth by preventing the formation of new blood vessels that supply the tumor with oxygen and nutrients and by inhibiting key angiogenic signaling pathways.
Option B: It selectively inhibits survivin (BIRC5) gene promoter activity and down-regulates survivin in vitro, leading to induction of apoptosis.
Option C: It is a potent inhibitor of carcinogenesis measured against chemical- or UV-initiated, phorbol-promoted mouse skin tumours.
Option D: It has potent anti-leukemic effects, inducing apoptosis in myeloid leukemia cell lines and primary AML cells at nanomolar concentrations.
"	A
3840	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=C(OC=C(C1=O)O)CO
Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit?
Option A: It exhibits activity against colon adinocarcinoma cells.
Option B: It exhibits anti-neoplastic function.
Option C: It exhibits inhibitory efficacy against the growth of human tumour cells.
Option D: It shows good activity against a variety of transplanted tumors.
"	B
156414	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4
Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit?
Option A: It has potent anti-leukemic effects, inducing apoptosis in myeloid leukemia cell lines and primary AML cells at nanomolar concentrations.
Option B: It works against esophageal squamous cell carcinoma in vitro and in vivo.
Option C: It selectively inhibits survivin (BIRC5) gene promoter activity and down-regulates survivin in vitro, leading to induction of apoptosis.
Option D: It inhibits the growth of A431 human epidermoid carcinoma and MKN-7 human stomach cancer cell lines.
"	B
6918670	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C/C=C(/C)\\C(=O)O[C@H]1C(=C[C@@]23[C@@]1([C@@H](C(=C[C@H](C2=O)[C@H]4[C@H](C4(C)C)C[C@H]3C)CO)O)O)C
Question about this molecule: Which kind of antineoplastic activity does this molecule have/exhibit?
Option A: It selectively inhibits survivin (BIRC5) gene promoter activity and down-regulates survivin in vitro, leading to induction of apoptosis.
Option B: It is a potent inhibitor of carcinogenesis measured against chemical- or UV-initiated, phorbol-promoted mouse skin tumours.
Option C: It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the vaccinia VIRUS and varicella zoster virus.
Option D: It has potent anti-leukemic effects, inducing apoptosis in myeloid leukemia cell lines and primary AML cells at nanomolar concentrations.
"	D
3011698	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC[C@H]1C=CCC[C@]2(O1)C[C@@H]3CC[C@H]4N3C(=N[C@]5([C@H]4C(=O)OCCCCCCCCCCCCCCCCCC(=O)N(CCCC(=O)N)CCCN)CCC[C@H](O5)C)N2
Question about this molecule: Which kind of antiviral activity does this molecule have/exhibit?
Option A: It exhibits antiviral activity against influenza virus.
Option B: It exhibits anti-HIV-1 and anti-HSV-1 activity.
Option C: It exhibits antiviral activity against herpes simplex virus.
Option D: It exhibits antiviral activity against influenza A virus.
"	B
11705156	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H](CC/C=C(\\C)/CO)[C@H]1CC[C@@]2([C@@]1(CCC3=C2C(=O)C[C@@H]4[C@@]3(CCC(=O)C4(C)C)C)C)C
Question about this molecule: Which kind of antiviral activity does this molecule have/exhibit?
Option A: It exhibits antiviral activity against herpes simplex virus type 1.
Option B: It displays effective antiviral activity against Herpes simplex virus type 1 and 2.
Option C: It exhibits antiviral activity against herpes simplex virus.
Option D: It exhibits antiviral activity against many lipid enveloped viruses including herpes simplex virus (HSV).
"	C
9928112	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1CC[C@@H]2[C@]3([C@@]1(CC4=C(C=CC(=C4O3)O)OC)C)CCCC2(C)C
Question about this molecule: Which kind of antiviral activity does this molecule have/exhibit?
Option A: It exhibits antiviral activity against influenza A virus.
Option B: It exhibits antiviral activity against influenza virus.
Option C: It exhibits antiviral activity against herpes simplex virus.
Option D: It exhibits activity against the influenza virus.
"	D
145343771	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CCC(CC1)C[C@@H](C(=O)N[C@@H](C[C@@H]2CCNC2=O)C=O)NC(=O)C3=CC4=CC=CC=C4N3
Question about this molecule: Which kind of antiviral activity does this molecule have/exhibit?
Option A: It is an inhibitor of SARS coronavirus main proteinase and inhibits SARS-CoV-2 replication in cell culture.
Option B: It is used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients.
Option C: It inhibits gene expression in HIV-1 at the transcriptional level through interference with Tat-mediated transactivation.
Option D: It has potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV.
"	A
3034285	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CO/C=C(\\C1=CC=CC=C1OC2=NC=NC(=C2)OC3=CC=CC=C3C#N)/C(=O)OC
Question about this molecule: Which kind of binding can this molecule cause?
Option A: It can bind RNA in bacterial ribosomes.
Option B: It can bind to the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane.
Option C: It can bind to the Qo site of Complex III of the mitochondrial electron transport chain.
Option D: It can bind to a site on the bacterial 23S ribosomal RNA of the 50S subunit.
"	C
135398671	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1[C@@H](N=C(N[C@H]1O)N)[C@H]2C(=O)NC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N/C(=C\\NC(=O)N)/C(=O)N2)CO)CO)NC(=O)C[C@H](CCCN)N
Question about this molecule: Which kind of binding can this molecule cause?
Option A: It can bind to the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane.
Option B: It can bind RNA in bacterial ribosomes.
Option C: It can bind to a site on the bacterial 23S ribosomal RNA of the 50S subunit.
Option D: It can cause binding to the 30S ribosome.
"	B
135398737	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Question about this molecule: Which kind of binding can this molecule cause?
Option A: It can bind to 5HT2 receptors.
Option B: It can cause binding to human 5-HT1B and 5-HT1D receptors.
Option C: It can cause binding to 5-HT2A receptors.
Option D: It can bind to 5-HT 2A/2C receptor subtype.
"	D
5288783	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H](/C=C/[C@H](C1CC1)O)[C@H]2CC[C@@H]\\3[C@@]2(CCC/C3=C\\C=C/4\\C[C@H](C[C@@H](C4=C)O)O)C
Question about this molecule: Which kind of binding can this molecule cause?
Option A: It can bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle.
Option B: It can bind to nicotinic-cholinergic receptors at the autonomic ganglia, in the adrenal medulla, at neuromuscular junctions, and in the brain.
Option C: It can bind to the VDR and modulate the T cells gene transcription of cell differentiation and proliferation related genes.
Option D: It can bind to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus.
"	C
9444	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=NC(=NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N
Question about this molecule: Which kind of binding can this molecule cause?
Option A: It can bind with high affinity to specific cytoplasmic receptors.
Option B: It can bind to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair machinery.
Option C: It can bind preferentially to the guanine and cytosine moieties of DNA.
Option D: It can covalently bind with DNA methyltransferases, preventing DNA synthesis and subsequent cytotoxicity.
"	D
3608	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(C(=O)NC(=O)N(C1=O)C)C2=CCCCC2
Question about this molecule: Which kind of binding can this molecule cause?
Option A: It can enhance the binding of GABA to GABAA receptors by acting on benzodiazepine receptors in the brain.
Option B: It can bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle.
Option C: It can bind to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus.
Option D: It can bind at a distinct binding site associated with a Cl- ionopore at the GABA-A receptor, increasing the duration of time for which the Cl- ionopore is open.
"	D
11434515	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C[N+]2(CCC1[C@H](C2)OC(=O)C(C3=CC=CS3)(C4=CC=CS4)O)CCCOC5=CC=CC=C5
Question about this molecule: Which kind of binding can this molecule cause?
Option A: It has a higher propensity to bind to muscarinic receptors than nicotinic receptors.
Option B: It can bind to nicotinic-cholinergic receptors at the autonomic ganglia, in the adrenal medulla, at neuromuscular junctions, and in the brain.
Option C: It can bind to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus.
Option D: It can bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle.
"	A
5865	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@]12CC(=O)[C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C
Question about this molecule: Which kind of binding can this molecule cause?
Option A: It can bind to 5HT2 receptors.
Option B: It can bind with high affinity to specific cytoplasmic receptors.
Option C: It can bind to estrogen receptors (ER).
Option D: It can bind and activate its receptors.
"	B
5479530	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1C(=NC(=O)C(=O)N1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\\OC)/C4=CSC(=N4)N)SC2)C(=O)O
Question about this molecule: Which kind of binding can this molecule cause?
Option A: It can occur mainly bound to proteins or polypeptides.
Option B: It can cause binding to carboxypeptidases, endopeptidases, and transpeptidases.
Option C: It can bind to a site on the bacterial 23S ribosomal RNA of the 50S subunit.
Option D: It can cause binding to the 30S ribosome.
"	B
91754	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)(C)C1=CC=C(C=C1)CSC2=C(C(=O)N(N=C2)C(C)(C)C)Cl
Question about this molecule: What is the right information about this molecule's bioaccumulation?
Option A: It tends to bioaccumulate.
Option B: It is not expected to bioaccumulate.
Option C: There is a slight concern regarding its ability to bioaccumulate.
Option D: It may bio-accumulate.
"	B
299	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1(=O)C2(C3(C4(C1(C5(C2(C3(C(C45Cl)(Cl)Cl)Cl)Cl)Cl)Cl)Cl)Cl)Cl
Question about this molecule: What is the right information about this molecule's bioaccumulation?
Option A: It was found to bioaccumulate and cause harmful health effects.
Option B: There is some concern regarding its potential for bioaccumulation.
Option C: There is a slight concern regarding its ability to bioaccumulate.
Option D: It bioaccumulates in animals by a factors up to a million-fold.
"	D
8606	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C=CCC2C1C(=O)N(C2=O)SC(Cl)(Cl)Cl
Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit?
Option A: It is classified as a Group B2, probable human carcinogen.
Option B: It is classified as a Group B1, probable human carcinogen.
Option C: It is classified as a Group C, possible human carcinogen.
Option D: It is classified as a Group 2B, possible human carcinogen.
"	A
4696	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C=C2C(=CC(=O)O2)C(O1)O
Question about this molecule: Which kind of carcinogenicity does this molecule have/exhibit?
Option A: It may be a carcinogen, but animal studies have remained inconclusive.
Option B: It is provisionally classified as a Group C, possible human carcinogen.
Option C: It is classified as a Group 1 carcinogen, carcinogenic to humans.
Option D: It is classified as a Group 2B, possible human carcinogen.
"	A
2794	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)N=C1C=C2C(=NC3=CC=CC=C3N2C4=CC=C(C=C4)Cl)C=C1NC5=CC=C(C=C5)Cl
Question about this molecule: What is the color of this molecule?
Option A: Amber to black.
Option B: Dark orange.
Option C: Green.
Option D: Brick red.
"	D
4829	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
Question about this molecule: What is the right information about this molecule's conversion?
Option A: It converts to anhydrous form at 203-207 °F.
Option B: The enantiomers interconvert in vivo with little consequence.
Option C: The levo-isomer is rapidly converted to the biologically available methyl-tetrahydrofolate form, while the dextro form is slowly excreted by the kidneys.
Option D: It is converted into its active form benazeprilat by cleavage of its ester group by the liver.
"	B
11463	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CCC(=C(C)C)CC1
Question about this molecule: What is the right information about this molecule's density?
Option A: It is more dense than water.
Option B: It is less dense than water.
Option C: It is slightly less dense than water.
Option D: It is somewhat less dense than water.
"	B
3224	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C2C(COS(=O)O1)C3(C(=C(C2(C3(Cl)Cl)Cl)Cl)Cl)Cl
Question about this molecule: What is the right information about this molecule's density?
Option A: It is slightly less dense than water.
Option B: It is more dense than water.
Option C: It is less dense than water.
Option D: It is somewhat less dense than water.
"	B
25078060	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCSC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]5CCCN5C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It has a very high potency and a comparable side effect profile to the parent compound.
Option B: It presents very large hypotensive effects.
Option C: It exhibits hypotensive and neuroprotective effects.
Option D: It has similar biological activity as antivirals and neuroprotective effects.
"	C
216326	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It may inhibit the action of pepsin by subsequent increases in pH.
Option B: It induces the secretion, or exocytosis, of insulin.
Option C: It mimics epilepsy by blocking the inhibitory action of GABA receptors.
Option D: It inhibits the secretion of TNF-alpha.
"	D
62751	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CCC(CC1)(C2=CC=CS2)N3CCCCC3
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It has dissociative anaesthetic, hallucinogenic, and stimulant effects.
Option B: It has stabilizing and quinidine-like effects on cardiac rhythm and weak inherent sympathomimetic action.
Option C: It can increase norepinephrine and dopamine efflux throughout the brain, impair cognition, and have locomotor-activating effects.
Option D: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and blockage of the receptors at high levels, leading to paralysis and death.
"	A
62751	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CCC(CC1)(C2=CC=CS2)N3CCCCC3
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It has a very high potency and a comparable side effect profile to the parent compound.
Option B: It is known to exacerbate psychopathological symptoms in schizophrenic patients, but there is no evidence of similar effects in healthy subjects.
Option C: It has similar effects to phencyclidine (PCP) but is more potent.
Option D: Its use has largely been supplanted by triptans in current therapy due to the class's greater selectivity and more favourable side effect profile.
"	C
25572	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC1=CC=C(C=C1)C(C2CC2)(C3=CN=CN=C3)O
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It can interfere with cell functions, such as meiosis and intracellular transportation, by binding to microtubules.
Option B: It can disrupt (depolymerize) microtubules, blocking anisotropic growth of plant cells.
Option C: It exhibits decreased mitosis and microtubule inhibition as its physiologic effects.
Option D: It reduces plant growth, resulting in reduced internode elongation and thus more compact plants.
"	D
72193864	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCN1C=C(C(=O)C2=C1C=C(C(=C2N)F)NC3CCCCC3)C(=O)O
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It leads to aberrant cell growth and proliferation in some cancers.
Option B: It induces cell death and growth arrest in Burkitt lymphoma cell lines at low concentrations.
Option C: It mimics epilepsy by blocking the inhibitory action of GABA receptors.
Option D: It induces cell cycle arrest and apoptosis in various cancer cells.
"	B
4763	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC1(C(=O)NC(=O)NC1=O)C2=CC=CC=C2
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It inhibits DNA synthesis and has some cell cycle phase specificity.
Option B: It inhibits root development and growth.
Option C: It inhibits DNA synthesis and causes cell death.
Option D: It can inhibit glutamate induced depolarizations.
"	D
50942	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC3OCCO3
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted.
Option B: It produces anti-androgenic effects in animals by reducing testosterone production and, at very high levels, reducing estrogen production, possibly by inhibiting testicular and ovarian steroidogenesis.
Option C: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation.
Option D: It has shown similar efficacy to theophylline in the treatment of asthma, but with significantly fewer side effects in animal and human studies.
"	D
3034285	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CO/C=C(\\C1=CC=CC=C1OC2=NC=NC(=C2)OC3=CC=CC=C3C#N)/C(=O)OC
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It prevents the generation of ATP by binding to the Qo site of Complex III of the mitochondrial electron transport chain.
Option B: It can reversibly stabilize the neuronal membrane by binding to sodium channels.
Option C: It inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations.
Option D: It inhibits DNA synthesis and stops the growth of cancer cells.
"	A
441074	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC1=CC2=C(C=CN=C2C=C1)[C@@H]([C@H]3C[C@@H]4CCN3C[C@@H]4C=C)O
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It has been associated with development of fatty liver, steatohepatitis, cirrhosis, and rare instances of clinically apparent acute liver injury with long term therapy.
Option B: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted.
Option C: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation.
Option D: It has been associated with fever, mild jaundice and clinically apparent liver injury in up to 2% of treated patients.
"	D
5284627	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(O[C@@H]2CO[C@@]3([C@H]([C@@H]2O1)OC(O3)(C)C)COS(=O)(=O)N)C
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It can decrease central nervous system disorganized electrical activity.
Option B: It exhibits decreased central nervous system disorganized electrical activity as its physiologic effect.
Option C: It exhibits decreased central nervous system disorganized electrical activity.
Option D: It can decrease central nervous system disorganized electrical activity to realize its physiologic effect.
"	D
135398671	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1[C@@H](N=C(N[C@H]1O)N)[C@H]2C(=O)NC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N/C(=C\\NC(=O)N)/C(=O)N2)CO)CO)NC(=O)C[C@H](CCCN)N
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It can bind RNA in bacterial ribosomes and inhibit protein synthesis.
Option B: It exhibits local anesthesia as its physiologic effect.
Option C: It irreversibly binds to the active site of the enzyme resulting in permanent inhibition.
Option D: It can exhibit general anesthesia as its physiologic effect.
"	A
3292	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCN1C(=O)C(NC1=O)C2=CC=CC=C2
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It decreases central nervous system disorganized electrical activity.
Option B: It can decrease central nervous system disorganized electrical activity to realize its physiologic effect.
Option C: It exhibits the physiologic effect of decreased central nervous system disorganized electrical activity.
Option D: It exhibits decreased central nervous system disorganized electrical activity as its physiologic effect.
"	B
2170	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT<sub>1A</sub> and terminal autoreceptors during acute use.
Option B: It down-regulates cerebral cortical β-adrenergic receptors and sensitizes post-synaptic serotonergic receptors with chronic use.
Option C: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use.
Option D: It can down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use.
"	D
55283	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@H]5CO[C@](O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It can cause increased large intestinal motility and inhibition of large intestine fluid/electrolyte absorption.
Option B: It inhibits ergosterol synthesis, resulting in increased cellular permeability and leakage of cellular contents.
Option C: It can inhibit ergosterol synthesis, resulting in increased cellular permeability causing leakage of cellular contents.
Option D: It inhibits ergosterol synthesis, resulting in increased cellular permeability.
"	C
10184665	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC(=C(C(=C1)Cl)COCCOCCCCCCNC[C@@H](C2=CC(=C(C=C2)O)CO)O)Cl
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It increases secretion by the exocrine glands, and produces contraction of the iris sphincter muscle and ciliary muscle (when given topically to the eyes) by mainly stimulating muscarinic receptors.
Option B: It can increase cyclic AMP, which is associated with relaxation of bronchial smooth muscle and inhibition of release of hypersensitivity mediators from mast cells in the lungs.
Option C: It inhibits lateral shoot branching, stimulates germination of Striga, and aids in the symbiosis of over 80% of terrestrial plants with fungi at arbuscular mycorrihizae in roots.
Option D: It can potentiate the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways.
"	B
36314	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It leads to suppression of microtubule dynamics.
Option B: It has microtubule inhibition.
Option C: It inhibits microtubules.
Option D: It can inhibit microtubules.
"	B
57469	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It can decrease coagulation factor activity to realize its physiologic effect.
Option B: It can increase cytokine activity and cytokine production.
Option C: It can increase coagulation factor VIII activity and concentration to realize its physiologic effect.
Option D: It can decrease prothrombin activity to realize its physiologic effect.
"	B
4170	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1NC2=CC(=C(C=C2C(=O)N1C3=CC=CC=C3C)S(=O)(=O)N)Cl
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It can exhibit increased diuresis.
Option B: It can exhibit increased diuresis as its physiologic effect.
Option C: It increases diuresis.
Option D: It can increase diuresis.
"	D
1775	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)C2(C(=O)NC(=O)N2)C3=CC=CC=C3
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It exhibits a decreased central nervous system disorganized electrical activity.
Option B: It decreases central nervous system disorganized electrical activity.
Option C: It can decrease central nervous system disorganized electrical activity.
Option D: It exhibits decreased central nervous system disorganized electrical activity.
"	D
9046	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=C3C=CC(=C4)OC5CCCC5
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It can increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.
Option B: It inhibits lateral shoot branching, stimulates germination of Striga, and aids in the symbiosis of over 80% of terrestrial plants with fungi at arbuscular mycorrihizae in roots.
Option C: It is limited by the development of movement disorders induced by dopamine-blockade, such as drug-induced parkinsonism, akathisia, dystonia, tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin changes.
Option D: It blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors, depresses the release of hypothalamic and hypophyseal hormones, and affects basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
"	A
708857	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CCCN=C1/C=C/C2=CC=CS2
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It is the prototypical agonist at nicotinic cholinergic receptors, dramatically stimulating neurons and ultimately blocking synaptic transmission.
Option B: It potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking cortical and limbic arousal following stimulation of the reticular pathways.
Option C: It causes longstanding nicotinic receptor activation, resulting in spastic paralysis of susceptible nematodes (worms).
Option D: It can potentiate the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways.
"	C
9871419	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCSC1=NC(=C2C(=N1)N(N=N2)[C@@H]3C[C@@H]([C@H]([C@H]3O)O)OCCO)N[C@@H]4C[C@H]4C5=CC(=C(C=C5)F)F
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It decreases platelet aggregation.
Option B: It can decrease platelet aggregation.
Option C: It exhibits decreased platelet aggregation.
Option D: It decreases prostaglandin production and platelet aggregation.
"	C
3152	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It causes significant discomfort throughout the day and requires frequent treatment with eye drops.
Option B: It shows modest benefits in cognition and/or behavior in 6-12 month controlled studies.
Option C: It has a decreased incidence of adverse effects compared to high dose monotherapy in the treatment of moderate hypertension.
Option D: It has shown similar efficacy to theophylline in the treatment of asthma, but with significantly fewer side effects in animal and human studies.
"	B
3478	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CN=C(C=N1)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It has reproductive effects in women exposed by inhalation to high levels and adverse effects on the developing fetus in animal tests.
Option B: It has the ability to cause serious adverse effects, including agranulocytosis.
Option C: It has shown similar efficacy to theophylline in the treatment of asthma, but with significantly fewer side effects in animal and human studies.
Option D: It induces the secretion, or exocytosis, of insulin.
"	D
4829	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors.
Option B: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use.
Option C: It promotes insulin sensitivity and the improved uptake of blood glucose via agonism at the peroxisome proliferator-activated receptor-gamma (PPARγ).
Option D: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT<sub>1A</sub> and terminal autoreceptors during acute use.
"	C
15938	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[N+]1=CC=C(C=C1)C2=CC=[N+](C=C2)C.[Cl-].[Cl-]
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It can suppress hunger signals and appetite.
Option B: It causes Paraquat poisoning, which can lead to suicide.
Option C: It can relax muscles in the airways to improve breathing.
Option D: It may lead to breathing difficulty.
"	B
107713	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(=CCO[C@H]1C2=C3[C@H](CC(OO[C@@H](N3C4=C2C=CC(=C4)OC)C=C(C)C)(C)C)N5[C@@]1(C(=O)N6CCC[C@H]6C5=O)O)C
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It can cause irritation of the eyes, cough, wheezing, asthmatic symptoms, pulmonary edema, pneumonia, dizziness, weakness, headache, and chest pains.
Option B: It can cause respiratory problems, stomach gas, rise in blood pressure, dizziness, convulsions, fainting, and coma.
Option C: Its antianginal effects were identified after it produced headaches in factory workers and relief from chest pain in workers with angina pectoris or heart failure.
Option D: It causes sustained tremors, convulsions, and death in the central nervous system.
"	D
134018	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(SC(=N1)C2=CC(=C(C=C2)OCC(C)C)C#N)C(=O)O
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It leads to glucose dependent increases in insulin and decreases in glucagon to improve control of blood sugar.
Option B: It reduces serum uric acid levels by inhibiting the activity of an enzyme responsible for the synthesis of uric acid.
Option C: It causes loss of potassium and an increase in serum uric acid.
Option D: It can reduce serum uric acid concentration through the inhibition of URAT1 and OAT4.
"	B
9444	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=NC(=NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It inhibits DNA synthesis and causes cell death.
Option B: It inhibits DNA synthesis and has some cell cycle phase specificity.
Option C: It inhibits DNA synthesis and stops the growth of cancer cells.
Option D: It inhibits DNA methyltransferase, impairing DNA methylation.
"	D
3608	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(C(=O)NC(=O)N(C1=O)C)C2=CCCCC2
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It can interfere with L-arginine in the production of nitric oxide, a key chemical to endothelial and hence cardiovascular health.
Option B: It binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open.
Option C: It binds to a distinct binding site associated with a Cl- ionopore at the GABA-A receptor, increasing the duration of time for which the Cl- ionopore is open.
Option D: It increases cellular permeability causing leakage of cellular contents by inhibiting the synthesis of ergosterol, an essential component of the fungal cell membrane.
"	C
448042	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It exhibits centrally-mediated muscle relaxation.
Option B: It causes centrally-mediated muscle relaxation.
Option C: It can exhibit centrally-mediated muscle relaxation as its physiologic effect.
Option D: It inhibits calcium sensitization to affect smooth muscle relaxation.
"	D
2343	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)CSCC2=NS(=O)(=O)C3=CC(=C(C=C3N2)Cl)S(=O)(=O)N
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It can reduce serum uric acid concentration through the inhibition of URAT1 and OAT4.
Option B: It causes loss of potassium and an increase in serum uric acid.
Option C: It reduces serum uric acid levels by inhibiting the activity of an enzyme responsible for the synthesis of uric acid.
Option D: It raises blood sugar through activation of hepatic receptors, stimulating glycogenolysis and the release of glucose.
"	B
49846579	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN=C8C(=C7)C=CN8)C
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It can cause increased cellular death.
Option B: It exhibits increased cellular death as its physiologic effect.
Option C: It exhibits increased diuresis as its physiologic effect.
Option D: It can exhibit increased diuresis as its physiologic effect.
"	A
2754	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It is the prototypical agonist at nicotinic cholinergic receptors, dramatically stimulating neurons and ultimately blocking synaptic transmission.
Option B: It may work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels.
Option C: It can inhibit both primary and secondary aggregation and reduce calcium-induced contractions.
Option D: It can cause nervous stimulation at low to moderate activation levels, but overstimulation and blockage of the receptors at high levels, leading to paralysis and death.
"	C
448812	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C[C@H]2C(=O)N[C@@H](CSSCCC(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N2C1)CC3=CNC4=CC=CC=C43)CC(=O)O)CCCCN=C(N)N)C(=O)N
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It exhibits decreased platelet production as its physiologic effect.
Option B: It can decrease platelet aggregation.
Option C: It exhibits decreased platelet aggregation.
Option D: It decreases prostaglandin production and platelet aggregation.
"	B
5311068	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(C(=CC=C1)[C@H](C)C2=CN=CN2)C
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It exhibits decreased platelet production as its physiologic effect.
Option B: It can exhibit general anesthesia as its physiologic effect.
Option C: It exhibits the physiologic effect of local anesthesia.
Option D: It exhibits decreased sympathetic activity as its physiologic effect.
"	B
2895	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN(C)CCC=C1C2=CC=CC=C2C=CC3=CC=CC=C31
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It can exhibit centrally-mediated muscle relaxation as its physiologic effect.
Option B: It causes centrally-mediated muscle relaxation.
Option C: It exhibits decreased sympathetic activity as its physiologic effect.
Option D: It exhibits centrally-mediated muscle relaxation.
"	B
2749	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=O)N(C(=C1)C2CCCCC2)O
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It inhibits DNA synthesis and stops the growth of cancer cells.
Option B: It can interfere with DNA replication and transcription by inhibiting DNA helicase activity.
Option C: It inhibits DNA synthesis and causes cell death.
Option D: It decreases DNA replication, protein synthesis, and RNA replication.
"	D
11256664	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C2C=C(C=CC2=C(C(=N1)C(=O)NCC(=O)O)O)OC3=CC=CC=C3
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It can be associated with mild serum enzyme elevations and has been linked to rare instances of clinically apparent liver injury.
Option B: It is associated with transient serum enzyme elevations during therapy and with rare instances of acute liver injury.
Option C: It stimulates red blood cell production in response to low oxygen levels.
Option D: It causes clinically apparent acute liver injury and rare instances of death.
"	C
4060	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC1(C(=O)N(C(=O)N1)C)C2=CC=CC=C2
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It decreases central nervous system disorganized electrical activity.
Option B: It can exhibit a decreased central nervous system disorganized electrical activity.
Option C: It exhibits a decreased central nervous system disorganized electrical activity.
Option D: It can decrease central nervous system disorganized electrical activity.
"	A
5284549	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCN[C@H]1C[C@@H](S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)C
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It has negligible effects on acid-base or electrolyte disturbances and other systemic adverse effects.
Option B: It has a decreased incidence of adverse effects compared to high dose monotherapy in the treatment of moderate hypertension.
Option C: It has shown similar efficacy to theophylline in the treatment of asthma, but with significantly fewer side effects in animal and human studies.
Option D: It has good tolerance, lack of toxicity, and no dose-limiting side effects.
"	A
8550	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CO[C@H]1[C@@H](C[C@@H]2CN3CCC4=C([C@H]3C[C@@H]2[C@@H]1C(=O)OC)NC5=CC=CC=C45)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It exhibits decreased blood pressure as its physiologic effect.
Option B: It can decrease cell membrane integrity to realize its physiologic effect.
Option C: It exhibits decreased sympathetic activity as its physiologic effect.
Option D: It can decrease blood pressure to realize its physiologic effect.
"	C
150311	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC(=CC=C1[C@@H]2[C@H](C(=O)N2C3=CC=C(C=C3)F)CC[C@@H](C4=CC=C(C=C4)F)O)O
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It causes centrally-mediated muscle relaxation.
Option B: It reduces the delivery of intestinal cholesterol to the liver.
Option C: It exhibits centrally-mediated muscle relaxation.
Option D: It can exhibit centrally-mediated muscle relaxation as its physiologic effect.
"	B
36324	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=C(C=C1)N=CN(C)C=NC2=C(C=C(C=C2)C)C)C
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It causes overexcitation, paralysis, and death in insects.
Option B: Acute inhalation exposure to it can cause irritation of the respiratory tract and eye irritation in humans.
Option C: It causes mucous membrane and eye irritation, and gastrointestinal effects.
Option D: It causes central nervous system depression and irritation of the eyes and mucous membranes upon acute exposure in humans.
"	A
25151352	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC(=NC=C1CC2=CNC3=C2C=C(C=N3)Cl)NCC4=CN=C(C=C4)C(F)(F)F
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It does not result in developmental effects during inhalation exposure in animal studies, but reproductive effects such as a decrease in fertility, reduced testicular weights, and decreased sperm production have been noted.
Option B: It causes debilitating symptoms, significant functional limitations, and a reduced quality of life in patients with tenosynovial giant cell tumors.
Option C: It is associated with transient and usually mild elevations in serum aminotransferase during therapy and to rare instances of self-limited, clinically apparent idiosyncratic acute liver injury as well as to cases of reactivation of hepatitis B in susceptible individuals.
Option D: It can cause transient serum enzyme elevations during therapy, rare cases of cholestatic hepatitis, instances of nodular regenerative hyperplasia, and sinusoidal obstruction syndrome when given in high doses.
"	B
132999	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)C[C@H]3CC4=CC(=C(C=C34)OC)OC
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It can cause transient serum enzyme elevations during therapy, rare cases of cholestatic hepatitis, instances of nodular regenerative hyperplasia, and sinusoidal obstruction syndrome when given in high doses.
Option B: It can cause blood stagnation and changes in hematocrit, activated partial thromboplastin time, international normalized ratio, and blood pressure should be monitored.
Option C: It can cause a decrease in systemic arterial blood pressure and systemic vascular resistance without a substantial reduction in resting heart rate, cardiac output, or stroke volume, apparently because of its combined α- and β-adrenergic blocking activity.
Option D: It selectively inhibits the ""funny"" channel pacemaker current (If) in the sinoatrial node, resulting in a lower heart rate and increased blood flow to the myocardium.
"	D
8606	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C=CCC2C1C(=O)N(C2=O)SC(Cl)(Cl)Cl
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It has a higher incidence of severe adverse effects compared to warfarin.
Option B: It is much safer and potent than thalidomide, with fewer adverse effects and toxicities.
Option C: It improves the outward appearance of many fruits, making them brighter and healthier-looking.
Option D: It has a decreased incidence of adverse effects compared to high dose monotherapy in the treatment of moderate hypertension.
"	C
441290	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(=O)O[C@H]1[C@H](C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(C[C@@H]([C@H](C4)O)N5CCOCC5)C)C)[N+]6(CCCC6)CC=C
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It can exhibit neuromuscular nondepolarizing blockade as its physiologic effect.
Option B: It exhibits neuromuscular nondepolarizing blockade.
Option C: It exhibits neuromuscular nondepolarizing blockade as its physiologic effect.
Option D: It can exhibit neuromuscular nondepolarizing blockade effects.
"	C
5311309	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)C1CCC(CC1)C(=O)N[C@H](CC2=CC=CC=C2)C(=O)O
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: Acute inhalation exposure to it can cause irritation of the respiratory tract and eye irritation in humans.
Option B: It causes severe respiratory tract irritation and inflammation in humans upon acute inhalation exposure.
Option C: It induces bronchodilation by relaxation of airway smooth muscles.
Option D: It induces an early insulin response to meals, decreasing postprandial blood glucose levels.
"	D
135409400	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C2=C(C=CC(=C2Cl)Cl)N=C3N1CC(=O)N3
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It can decrease blood pressure to realize its physiologic effect.
Option B: It exhibits decreased platelet production as its physiologic effect.
Option C: It can decrease cell membrane integrity to realize its physiologic effect.
Option D: It exhibits decreased blood pressure as its physiologic effect.
"	B
5770	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CO[C@H]1[C@@H](C[C@@H]2CN3CCC4=C([C@H]3C[C@@H]2[C@@H]1C(=O)OC)NC5=C4C=CC(=C5)OC)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It exhibits decreased blood pressure as its physiologic effect.
Option B: It exhibits decreased platelet production as its physiologic effect.
Option C: It can decrease blood pressure to realize its physiologic effect.
Option D: It exhibits decreased sympathetic activity as its physiologic effect.
"	D
667468	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN(C)CC/C=C\\1/C2=CC=CC=C2COC3=CC=CC=C31
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT<sub>1A</sub> and terminal autoreceptors during acute use.
Option B: It down-regulates cerebral cortical β-adrenergic receptors and sensitizes post-synaptic serotonergic receptors with chronic use.
Option C: It down-regulates cerebral cortical &beta;-adrenergic receptors and sensitizes post-synaptic serotonergic receptors with chronic use, similar to TCAs.
Option D: It can down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use.
"	C
5311181	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC#CCC(C)[C@@H](/C=C/[C@H]1[C@@H](C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)O
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It exhibits decreased sympathetic activity as its physiologic effect.
Option B: It can result in a decrease in heart rate and vascular resistance.
Option C: It exhibits decreased platelet production as its physiologic effect.
Option D: It can dilate systemic and pulmonary arterial vascular beds.
"	D
2720	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)N=CN2
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It can exhibit increased diuresis.
Option B: It can increase diuresis.
Option C: It increases diuresis.
Option D: It exhibits increased diuresis as its physiologic effect.
"	A
62887	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[N@@+]1(CCC2=CC(=C(C=C2[C@H]1CC3=CC(=C(C=C3)OC)OC)OC)OC)CCC(=O)OCCCCCOC(=O)CC[N@+]4(CCC5=CC(=C(C=C5[C@H]4CC6=CC(=C(C=C6)OC)OC)OC)OC)C
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It can exhibit neuromuscular nondepolarizing blockade effects.
Option B: It can exhibit neuromuscular nondepolarizing blockade as its physiologic effect.
Option C: It exhibits neuromuscular nondepolarizing blockade.
Option D: It exhibits neuromuscular nondepolarizing blockade as its physiologic effect.
"	A
9865528	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)[C@H](CNCCC2=CC=C(C=C2)NC(=O)CC3=CSC(=N3)N)O
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It can produce significant adverse effects in the GI tract.
Option B: It has a comparatively favorable adverse effect profile.
Option C: It causes harmful health effects and bioaccumulates.
Option D: It has a very high potency and a comparable side effect profile to the parent compound.
"	B
3702	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1CC2=CC=CC=C2N1NC(=O)C3=CC(=C(C=C3)Cl)S(=O)(=O)N
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It increases diuresis.
Option B: It can exhibit increased diuresis.
Option C: It can increase diuresis.
Option D: It exhibits increased diuresis as its physiologic effect.
"	A
64143	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(C=CC=C1O)C(=O)N[C@@H](CSC2=CC=CC=C2)[C@@H](CN3C[C@H]4CCCC[C@H]4C[C@H]3C(=O)NC(C)(C)C)O
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It may result in an exacerbation of the underlying chronic hepatitis B or C in HBV or HCV coinfected patients receiving highly active antiretroviral therapy.
Option B: It may result in an exacerbation of the underlying chronic hepatitis B or C in HBV or HCV coinfected patients.
Option C: It may result in an exacerbation of the underlying chronic hepatitis B or C.
Option D: It may exacerbate underlying chronic hepatitis B or C in coinfected patients.
"	D
60795	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CC(=O)NC2=C1C=CC(=C2)OCCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders.
Option B: It has shown similar efficacy to theophylline in the treatment of asthma, but with significantly fewer side effects in animal and human studies.
Option C: It is known to exacerbate psychopathological symptoms in schizophrenic patients, but there is no evidence of similar effects in healthy subjects.
Option D: It exhibits antipsychotic effects primarily by partial agonism at the D2 receptor.
"	D
9853053	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C(=O)NCC(F)(F)F
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy that are usually accompanied by an increase in hepatic fat.
Option B: It is associated with elevations in serum aminotransferase levels, acute liver injury, and noncirrhotic portal hypertension with long-term use.
Option C: It has been linked to mild, transient elevations in serum aminotransferase levels during therapy as well as rare instances of idiosyncratic drug-induced liver disease.
Option D: It can cause transient mild-to-moderate serum aminotransferase elevations during the first 1 or 2 weeks of treatment, but has not been implicated in cases of clinically apparent liver injury with jaundice.
"	A
123606	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN(C)CCC1=CNC2=C1C=C(C=C2)CS(=O)(=O)N3CCCC3
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It has serious side effects including allergic reactions, irregular heartbeats, and low or high blood pressure, as well as less serious side effects such as headaches, insomnia, and impotence.
Option B: It narrows blood vessels in the brain, stops pain signals from being sent to the brain, and stops the release of certain natural substances that cause pain, nausea, and other symptoms of migraine.
Option C: It can cause irritation of the eyes, cough, wheezing, asthmatic symptoms, pulmonary edema, pneumonia, dizziness, weakness, headache, and chest pains.
Option D: It can cause respiratory problems, stomach gas, rise in blood pressure, dizziness, convulsions, fainting, and coma.
"	B
10255275	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@]12CC[C@@]3([C@@]([C@]1(CC4=C(O2)C=C(OC4=O)C5=CC(=C(C=C5)OC)OC)O)(C(=O)C=CC3(C)C)C)O
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It can inhibit the hydrolysis of acetylcholine released from functioning cholinergic neurons.
Option B: It induces the effect of inhibiting the enzyme acetylcholinesterase in peripheral nerve endings.
Option C: It increases acetylcholine neurotransmission by blocking its breakdown in the synaptic cleft.
Option D: It is a competitive, reversible antagonist of muscarinic receptors and blocks the effects of acetylcholine and other choline esters.
"	B
89594	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CCC[C@H]1C2=CN=CC=C2
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It increases acetylcholine neurotransmission by blocking its breakdown in the synaptic cleft.
Option B: It increases secretion by the exocrine glands, and produces contraction of the iris sphincter muscle and ciliary muscle (when given topically to the eyes) by mainly stimulating muscarinic receptors.
Option C: It is the prototypical agonist at nicotinic cholinergic receptors, dramatically stimulating neurons and ultimately blocking synaptic transmission.
Option D: It dramatically stimulates neurons and ultimately blocks synaptic transmission as the prototypical agonist at nicotinic cholinergic receptors.
"	C
60648	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(SC=C1)C(=CCCN2CCC[C@H](C2)C(=O)O)C3=C(C=CS3)C
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It exhibits the physiologic effect of decreased central nervous system disorganized electrical activity.
Option B: It can decrease central nervous system disorganized electrical activity to realize its physiologic effect.
Option C: It exhibits decreased central nervous system disorganized electrical activity as its physiologic effect.
Option D: It decreases central nervous system disorganized electrical activity.
"	A
5035	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It causes significant discomfort throughout the day and requires frequent treatment with eye drops.
Option B: It causes severe respiratory tract irritation and inflammation in humans upon acute inhalation exposure.
Option C: It causes overexcitation, paralysis, and death in insects.
Option D: It exhibits tissue-specific effects distinct from estradiol and is labeled a SERM.
"	D
441289	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@@H]([C@]2(C[C@@H]1[N+]4(CCCCC4)C)C)CC[C@]5([C@H]3C[C@@H]([C@@H]5OC(=O)C)[N+]6(CCCCC6)C)C
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It exhibits neuromuscular nondepolarizing blockade.
Option B: It can exhibit neuromuscular nondepolarizing blockade effects.
Option C: It exhibits neuromuscular depolarizing blockade.
Option D: It exhibits neuromuscular nondepolarizing blockade as its physiologic effect.
"	A
174174	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)C(CO)C3=CC=CC=C3
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It dramatically stimulates neurons and ultimately blocks synaptic transmission as the prototypical agonist at nicotinic cholinergic receptors.
Option B: It is a competitive, reversible antagonist of muscarinic receptors and blocks the effects of acetylcholine and other choline esters.
Option C: It acts by blocking central cholinergic receptors and balancing cholinergic and dopaminergic activity in the basal ganglia.
Option D: It is the prototypical agonist at nicotinic cholinergic receptors, dramatically stimulating neurons and ultimately blocking synaptic transmission.
"	B
4158	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC(=O)C(C1CCCCN1)C2=CC=CC=C2
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It blocks the D2 somatodendritic autoreceptor, resulting in the blockade of postsynaptic dopamine receptors in the mesolimbic system and an increased dopamine turnover.
Option B: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use.
Option C: It can increase norepinephrine and dopamine efflux throughout the brain, impair cognition, and have locomotor-activating effects.
Option D: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT<sub>1A</sub> and terminal autoreceptors during acute use.
"	C
118856773	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H]2C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2)C(C)C)CC(=O)N)CO)CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]3CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N3)CC(C)C)CC(=O)N)CCC(=O)N)CO)CCC(=O)O)[C@@H](C)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)N)C(=O)N1)CCCCN)CC(=O)N)CCC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N5CCC[C@H]5C(=O)N[C@@H](CCCCN)C(=O)N6CCC[C@H]6C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC7=CNC=N7)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC8=CC=CC=C8)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N9CCC[C@H]9C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)O)CCC(=O)N)CC(=O)N)CCCCN)CCC(=O)O)CC(=O)O)CO)CC(C)C
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It enhances the effect of topically applied silver, tin, and zinc salts in preventing dental cavities.
Option B: It enhances the effects of GABA by increasing GABA affinity for the GABA receptor.
Option C: It activates endothelial cells and platelets and enhances the formation of thrombi.
Option D: It mimics epilepsy by blocking the inhibitory action of GABA receptors.
"	C
135400189	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCC1=NC(=C2N1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CC)OCC)C
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It exhibits increased cellular death as its physiologic effect.
Option B: It exhibits increased diuresis as its physiologic effect.
Option C: It can exhibit increased blood flow into the penis, resulting in erection.
Option D: It can exhibit increased diuresis as its physiologic effect.
"	C
21867154	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCC(CCC)C(=O)OC1CC2CCC(C1)[N+]2(C)C.[Br-]
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It can cause metabolic acidosis, intracranial hemorrhage, feeding difficulties, and significant neurological symptoms.
Option B: It has therapeutic effects similar to salicylates, but lacks anti-inflammatory, antiplatelet, and gastric ulcerative effects.
Option C: It can decrease motility of the gastrointestinal and urinary tracts and inhibit gastric acid secretion.
Option D: By inhibiting the endogenous production of cholesterol within the liver, it lowers abnormal cholesterol and lipid levels and ultimately reduces the risk of cardiovascular disease.
"	C
3476	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC1=C(CN(C1=O)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)C)C
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It raises blood sugar through activation of hepatic receptors, stimulating glycogenolysis and the release of glucose.
Option B: It leads to glucose dependent increases in insulin and decreases in glucagon to improve control of blood sugar.
Option C: It can stimulate the release of insulin from the pancreatic beta cells and increase the insulin-mediated peripheral glucose uptake.
Option D: It stimulates the release of insulin from functioning pancreatic beta cells and increases sensitivity of peripheral tissues to insulin.
"	C
193962	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=CC(=C1OC2=NC(=NC(=C2Br)N)NC3=CC=C(C=C3)C#N)C)C#N
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation.
Option B: Common side effects include mild to moderate rash within the first 6 weeks of therapy, nausea, diarrhea, and peripheral neuropathy.
Option C: It has serious side effects including allergic reactions, irregular heartbeats, and low or high blood pressure, as well as less serious side effects such as headaches, insomnia, and impotence.
Option D: It can cause elevated blood levels of ammonia, leading to neurologic problems, cerebral edema, coma, and death in a rare genetic disorder.
"	B
216326	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It is much safer and potent than thalidomide, with fewer adverse effects and toxicities.
Option B: It does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders.
Option C: It has reproductive effects in women exposed by inhalation to high levels and adverse effects on the developing fetus in animal tests.
Option D: It has shown similar efficacy to theophylline in the treatment of asthma, but with significantly fewer side effects in animal and human studies.
"	A
11679714	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCCCCCCOC1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)N[C@H]3CC(CNC(=O)[C@@H]4[C@H]([C@H](CN4C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]5C[C@H](CN5C(=O)[C@@H](NC3=O)[C@@H](C)O)O)[C@@H](CC6=CC=C(C=C6)O)O)CO)C)O)NCCN
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It has a minimal side effect profile and uncomplicated metabolic profile, making it suitable for the treatment of mycotic outbreaks such as vaginal yeast infections and athlete's foot.
Option B: It could potentially affect the cellular morphology and metabolic status of Candida albicans cells within biofilms as a new representative of the echinocandins.
Option C: It has therapeutic effects similar to salicylates, but lacks anti-inflammatory, antiplatelet, and gastric ulcerative effects.
Option D: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation.
"	B
5311221	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)OC(=O)CCC/C=C\\C[C@H]1[C@H](C[C@H]([C@@H]1CC[C@H](CCC2=CC=CC=C2)O)O)O
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It has a broad spectrum of action, being systemic with protective and curative action.
Option B: It does not normally result in systemic adverse effects.
Option C: It has a very high potency and a comparable side effect profile to the parent compound.
Option D: It has a comparatively favorable adverse effect profile.
"	B
135449332	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(C=C(C=C1)N2C(=O)C(=C(N2)C)N=NC3=CC=CC(=C3O)C4=CC(=CC=C4)C(=O)O)C
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It can exhibit centrally-mediated muscle relaxation as its physiologic effect.
Option B: It causes centrally-mediated muscle relaxation.
Option C: It exhibits centrally-mediated muscle relaxation.
Option D: It increases megakaryocyte maturation and platelet production.
"	D
5734	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C2C(=C1)C(=NO2)CS(=O)(=O)N
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It exhibits decreased central nervous system disorganized electrical activity.
Option B: It exhibits a decreased central nervous system disorganized electrical activity.
Option C: It can decrease central nervous system disorganized electrical activity.
Option D: It exhibits the physiologic effect of decreased central nervous system disorganized electrical activity.
"	B
5533	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CN(CCN1CCCN2C(=O)N3C=CC=CC3=N2)C4=CC(=CC=C4)Cl
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It has therapeutic effects similar to salicylates, but lacks anti-inflammatory, antiplatelet, and gastric ulcerative effects.
Option B: It does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders.
Option C: It has developmental effects, such as CNS dysfunction, attention deficits, and minor craniofacial and limb anomalies, in the children of pregnant women exposed to high levels of this molecule or mixed solvents by inhalation.
Option D: It impairs energy-requiring processes, such as recovery from potentially lethal damage induced by radiation treatment and some cytotoxic drugs.
"	B
10077130	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCOC(=O)N[C@@H]1CC[C@@H]2[C@@H](C1)C[C@@H]3[C@H]([C@H]2/C=C/C4=NC=C(C=C4)C5=CC(=CC=C5)F)[C@H](OC3=O)C
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors during acute use.
Option B: It promotes insulin sensitivity and the improved uptake of blood glucose via agonism at the peroxisome proliferator-activated receptor-gamma (PPARγ).
Option C: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT<sub>1A</sub> and terminal autoreceptors during acute use.
Option D: It can prevent thrombin-related platelet aggregation by inhibiting PAR-1, a thrombin receptor expressed on platelets.
"	D
6918670	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C/C=C(/C)\\C(=O)O[C@H]1C(=C[C@@]23[C@@]1([C@@H](C(=C[C@H](C2=O)[C@H]4[C@H](C4(C)C)C[C@H]3C)CO)O)O)C
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It exhibits increased diuresis at the loop of Henle as its physiologic effect.
Option B: It exhibits increased cellular death as its physiologic effect.
Option C: It can exhibit increased diuresis as its physiologic effect.
Option D: It exhibits increased diuresis as its physiologic effect.
"	B
5479530	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1C(=NC(=O)C(=O)N1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\\OC)/C4=CSC(=N4)N)SC2)C(=O)O
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It results in the formation of defective cell walls and cell death by binding to certain enzymes.
Option B: It is associated with transient serum enzyme elevations during therapy and with rare instances of acute liver injury.
Option C: It can lead to the accumulation of itself and glycine in the brain when its plasma concentrations increase.
Option D: It can be associated with mild serum enzyme elevations and has been linked to rare instances of clinically apparent liver injury.
"	A
4493	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(C(=O)N(C(=O)N1)C2=CC(=C(C=C2)[N+](=O)[O-])C(F)(F)F)C
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It can increase cyclic AMP, which is associated with relaxation of bronchial smooth muscle and inhibition of release of hypersensitivity mediators from mast cells in the lungs.
Option B: By inhibiting the endogenous production of cholesterol within the liver, it lowers abnormal cholesterol and lipid levels and ultimately reduces the risk of cardiovascular disease.
Option C: It blocks the action of androgens of adrenal and testicular origin that stimulate the growth of normal and malignant prostatic tissue.
Option D: It leads to relaxation of smooth muscle in the prostate and detrusor muscles in the bladder, improving urinary flow.
"	C
8447	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C2C(=C1)N=C(S2)SSC3=NC4=CC=CC=C4S3
Question about this molecule: Which kind of effects does this molecule have/exhibit?
Option A: It increases histamine release and cell-mediated immunity.
Option B: It causes centrally-mediated muscle relaxation.
Option C: It can exhibit centrally-mediated muscle relaxation as its physiologic effect.
Option D: It exhibits centrally-mediated muscle relaxation.
"	A
122724	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(C(=O)C=C2C1=CC=C3[C@]2(CC[C@@]4([C@@]3(CC[C@@]5([C@H]4C[C@](CC5)(C)C(=O)O)C)C)C)C)O
Question about this molecule: What is the enzyme inhibition of this molecule?
Option A: It potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM).
Option B: It inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).
Option C: It is a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2).
Option D: It acts as an inhibitor of the enzyme mu-calpain (EC 3.4.22.52).
"	A
177014	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@]12[C@H](CC3=CC4=C(C=C3[C@H]1N(CC5=C2C=CC6=C5OCO6)C)OCO4)O
Question about this molecule: What is the enzyme inhibition of this molecule?
Option A: It potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM).
Option B: It is a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2).
Option C: It acts as an inhibitor of the enzyme mu-calpain (EC 3.4.22.52).
Option D: It acts as an acetylcholinesterase inhibitor.
"	D
25180898	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(=CCC1=C(C=C(C=C1)C2=C(C(=O)C3=C4C(=C(C(=C3O2)CC=C(C)C)O)CCC(O4)(C)C)O)O)C
Question about this molecule: What is the enzyme inhibition of this molecule?
Option A: It exhibits alpha-glucosidase inhibitory activity.
Option B: It is an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor.
Option C: It acts as an inhibitor of the enzyme mu-calpain (EC 3.4.22.52).
Option D: It exhibits inhibitory activity against alpha-amylase and lipase.
"	A
124219	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(C=CC2=C(O1)C3=CC=CC=C3C(=C2C(=O)OC)O)C
Question about this molecule: What is the enzyme inhibition of this molecule?
Option A: It acts as an inhibitor of the enzyme mu-calpain (EC 3.4.22.52).
Option B: It potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM).
Option C: It inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).
Option D: It is a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2).
"	D
70697882	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(C=CC2=C(O1)C=C(C3=C2OC(=C(C3=O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)C5=CC(=C(C=C5)O)O)O)C
Question about this molecule: What is the enzyme inhibition of this molecule?
Option A: It acts as a cyclooxygenase 2 inhibitor.
Option B: It acts as an acetylcholinesterase inhibitor.
Option C: It exhibits inhibitory activities towards arachidonate 5-lipoxygenase and cyclooxygenase 2.
Option D: It inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase.
"	A
11685925	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(CCC2=C3C(=C(C(=C2O1)C4CC(OC5=C4C6=C(C(=C5)O)C(=O)C7=C(N6)C(=CC=C7)O)(C)C)O)C(=O)C8=C(N3)C(=CC=C8)O)C
Question about this molecule: What is the enzyme inhibition of this molecule?
Option A: It is an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor.
Option B: It exhibits alpha-glucosidase inhibitory activity.
Option C: It acts as an inhibitor of the enzyme mu-calpain (EC 3.4.22.52).
Option D: It exhibits inhibitory activity against alpha-amylase and lipase.
"	B
6616	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(C2CCC(C2)C1=C)C
Question about this molecule: How is the flammability of this molecule
Option A: It is flammable over a wide range of vapor/air concentrations.
Option B: It can form a very flammable mixture with combustible materials.
Option C: It emits flammable vapors when heated.
Option D: It emits flammable vapors above 150 °F.
"	C
27661	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1[C@@H]([C@@H]2[C@H](O1)[C@@H](CO2)O[N+](=O)[O-])O
Question about this molecule: How is the flammability of this molecule
Option A: It is flammable.
Option B: It is extremely flammable.
Option C: It is very flammable.
Option D: It is highly flammable.
"	C
3152	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC
Question about this molecule: Which kind of half-life does this molecule have/exhibit?
Option A: It has a short half-life of 3-5 minutes.
Option B: It has a half-life of about 70 hours.
Option C: It has a half-life of 110 minutes.
Option D: It has a half-life of around 120 days.
"	B
3478	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CN=C(C=N1)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3
Question about this molecule: Which kind of half-life does this molecule have/exhibit?
Option A: It has the shortest half-life and duration of action.
Option B: It has a half-life of around 120 days.
Option C: It has a half-life of 110 minutes.
Option D: It has a half-life of about 70 hours.
"	A
24822371	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CNC1=CC=C(C=C1)/C=C/C2=CN=C(C=C2)OCCOCCOCC[18F]
Question about this molecule: Which kind of half-life does this molecule have/exhibit?
Option A: It has a half-life of 110 minutes.
Option B: It has a half-life of about 70 hours.
Option C: It has a short half-life of 3-5 minutes.
Option D: It has a half-life of around 120 days.
"	A
110635	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CC(=O)N2[C@@H](C1=O)CC3=C([C@H]2C4=CC5=C(C=C4)OCO5)NC6=CC=CC=C36
Question about this molecule: Which kind of half-life does this molecule have/exhibit?
Option A: It has a comparatively longer half-life.
Option B: It has a longer half-life.
Option C: It has a very long half-life.
Option D: It has a relatively long half-life.
"	B
5479530	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1C(=NC(=O)C(=O)N1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\\OC)/C4=CSC(=N4)N)SC2)C(=O)O
Question about this molecule: Which kind of half-life does this molecule have/exhibit?
Option A: It has a very short half-life.
Option B: It has a long half-life.
Option C: It has a very long half-life.
Option D: It has a short half-life.
"	C
11671819	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H](CCC(=C)C(C)(C)O)[C@H]1CC[C@@]2([C@@]1(CCC3=C2CC[C@@H]4[C@@]3(CC[C@@H]([C@@]4(C)CO)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)C)C)C
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity against NF-kappaB.
Option B: It exhibits inhibitory activity against platelet aggregation.
Option C: It exhibits inhibitory activity against DNA polymerase and platelet aggregation.
Option D: It exhibits inhibitory activity against chymotrypsin.
"	D
11671631	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H](CCC(=C)C(C)C)[C@H]1CC[C@@]2([C@@]1(CCC3=C2CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)C)C)C
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity against platelet aggregation.
Option B: It exhibits inhibitory activity against NF-kappaB.
Option C: It exhibits inhibitory activity against DNA polymerase and platelet aggregation.
Option D: It exhibits inhibitory activity against chymotrypsin.
"	D
72551430	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC2=CC(=C3C(=C2)OC(=C(C3=O)O[C@@H]4[C@H]([C@](CO4)(COC(=O)C)O)O)C5=CC=C(C=C5)O)O)O)O)O
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity against chymotrypsin.
Option B: It exhibits inhibitory activity against topoisomerase II.
Option C: It exhibits inhibitory activity against topoisomerase I.
Option D: It exhibits inhibitory activity against topoisomerase I and II.
"	D
9796904	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CC2CC3=CC(C4C=C(CCC4=O)CC1CN2)C(=O)CC3
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity against chymotrypsin.
Option B: It exhibits inhibitory activity against DNA polymerase and platelet aggregation.
Option C: It exhibits inhibitory effect on platelet aggregation.
Option D: It exhibits inhibitory activity against platelet aggregation.
"	D
9860695	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC2=C(C=N1)C(=O)C3=C(O2)C=C(C(=C3C(=O)O)O)O
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity against metallo-beta-lactamases.
Option B: It exhibits inhibitory activity against NF-kappaB.
Option C: It exhibits inhibitory activity against tyrosinase.
Option D: It exhibits inhibitory activity against chymotrypsin.
"	A
5353939	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1CC2=C(C(O1)OC)C(=O)C3=C(O2)C=C(C(=C3C(=O)O)O)O
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity against metallo-beta-lactamases.
Option B: It exhibits inhibitory activity against chymotrypsin.
Option C: It exhibits inhibitory activity against tyrosinase.
Option D: It exhibits inhibitory activity against NF-kappaB.
"	A
44560613	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC[C@@H](OC1=O)[C@@H](C)[C@H]2CC[C@@]3([C@@]2(CCC4=C3CC[C@@H]5C(=C4)C=CC(=O)OC5(C)C)C)C
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity against HIV-1 RNAse H.
Option B: It exhibits inhibitory activity towards HIV-1 protease.
Option C: It exhibits inhibitory activity against HIV protease.
Option D: It exhibits inhibitory activity against HIV-1 integrase.
"	C
70680257	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CO[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O[C@H]2[C@H]3[C@H]([C@H]4[C@@H]([C@@]35C=C(C(=O)O5)C(=O)C6=CC(=C(C=C6)OC)O)O4)C(=CO2)C(=O)OC)CO)O)O
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity on ADP-mediated platelet activation and aggregation.
Option B: It exhibits significant inhibition of UVB-induced Activator Protein-1 (AP-1) activity in cell cultures.
Option C: It inhibits excitatory neurotransmission through actions on kainate and AMPA receptors.
Option D: It exhibits inhibitory activity on muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites.
"	B
86417	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC2=C(C=C1F)C(=O)N(C(=N2)N3C=NC=N3)C4=C(C=C(C=C4)Cl)Cl
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It has a role as an EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor and an antifungal agrochemical.
Option B: It is an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor.
Option C: It has a role as an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor and an antifungal agrochemical.
Option D: It inhibits dopa decarboxylase and depletes animal tissues of norepinephrine.
"	C
86389	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=NC(=C(S1)C(=O)NC2=C(C=C(C=C2Br)OC(F)(F)F)Br)C(F)(F)F
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It has a role as an EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor.
Option B: It is an EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor.
Option C: It inhibits carbonic anhydrase in the ciliary processes of the eye.
Option D: It has a role as an EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor and an antifungal agrochemical.
"	D
71306323	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC2=C(C=C(C=C2)C3=C(C(=O)C4=C(C=C(C=C4O3)O)O)O[C@H]5[C@@H]([C@@H]([C@@H]([C@H](O5)CO)O)O)O)O)O)O)O
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity against COX-1 and COX-2.
Option B: It exhibits inhibitory activity towards cyclooxygenases (COX-1 and COX-2).
Option C: It exhibits inhibitory activity against cyclooxygenase 1 and 2.
Option D: It exhibits inhibitory activity against COX-2 and 5-lipooxygenase.
"	C
25171947	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@]12CC[C@@H]3[C@@H]([C@H]1[C@](CC[C@H]2O)(C)O)OC(=O)C3=C
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity against chymotrypsin.
Option B: It exhibits inhibitory activity against protein kinase C.
Option C: It exhibits inhibitory activity against melanogenesis.
Option D: It exhibits inhibitory activity against tyrosinase.
"	C
387447	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: B([C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
Option B: It exhibits folic acid synthesis inhibitory activity.
Option C: It exhibits Na+/Cl- reabsorption inhibitory activity.
Option D: It exhibits inhibitory activity on protein association of L-BMAA.
"	A
10054688	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(C2=C(C(=C1O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)COC(=O)/C=C/C4=CC=C(C=C4)O)O)O)O)C)O[C@@H](CC2=O)C5=C(C=CC(=C5)O)O)O
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity against HIV protease.
Option B: It exhibits inhibitory activity against alpha-glucosidase.
Option C: It exhibits inhibitory activity against alpha-amylase.
Option D: It exhibits inhibitory activity against aldose reductase.
"	D
135533054	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C2C=C(C(=CC2=C1)C(=O)N/N=C/C3=CC(=C(C=C3)O)O)O
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity on muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites.
Option B: It is a cell-permeable, reversible noncompetitive inhibitor of the GTPase activity of dynamin 1 and 2 and Drp1 (mitochondrial), while exhibiting no significant effect against two other small GTPases, MxA and Cdc42.
Option C: It exhibits inhibitory activity on ADP-mediated platelet activation and aggregation.
Option D: It inhibits excitatory neurotransmission through actions on kainate and AMPA receptors.
"	B
70698140	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC2=CC(=C3C(=C2)OC(=C(C3=O)O[C@H]4[C@@H]([C@](CO4)(CO)O)O)C5=CC=C(C=C5)O)O)O)O)O
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity against topoisomerase I and II.
Option B: It exhibits inhibitory activity against chymotrypsin.
Option C: It exhibits inhibitory activity against topoisomerase II.
Option D: It exhibits inhibitory activity against topoisomerase I.
"	C
9988405	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)O)O)O)O)O)O)O)OC
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity against caspase-1.
Option B: It exhibits inhibitory activity against tyrosinase.
Option C: It exhibits inhibitory effect towards the release of leucotrienes.
Option D: It exhibits inhibitory activity against chymotrypsin.
"	C
637122	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1[C@H]([C@H](OC2=C1C(=CC3=C2[C@@H]4[C@H]([C@](O3)(OC5=CC(=CC(=C45)O)O)C6=CC(=C(C(=C6)O)O)O)O)O)C7=CC(=C(C=C7)O)O)O
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity against HIV protease.
Option B: It exhibits inhibitory activity against HIV-1 integrase.
Option C: It exhibits inhibitory activity towards HIV-1 protease.
Option D: It exhibits inhibitory activity against HIV-1 RNAse H.
"	C
11569021	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H](CCC(=C)C(C)(C)O)[C@H]1CC[C@@]2([C@@]1(CCC3=C2C(=O)C[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)C)C
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity against chymotrypsin.
Option B: It exhibits inhibitory activity against DNA polymerase and platelet aggregation.
Option C: It exhibits inhibitory activity against NF-kappaB.
Option D: It exhibits inhibitory activity against platelet aggregation.
"	A
57336745	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1C2=CN=C3C=CC(=CC3=C2N(C1=O)C4=CC(=C(C=C4)N5CCNCC5)C(F)(F)F)C6=CN=C(C=C6)OC.C(=C\\C(=O)O)\\C(=O)O
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: A dual PI3K/mTOR inhibitor.
Option B: It exhibits inhibitory activity on PAR-1, a thrombin receptor expressed on platelets.
Option C: It exhibits inhibitory activity on phosphoinositide-3 kinase (PI3K) and mammalian target of rapamycin (mTOR).
Option D: It exhibits inhibitory activity on ADP-mediated platelet activation and aggregation.
"	A
10102192	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1[C@H]2[C@H](C[C@@H]3[C@@]2(CC[C@H]4[C@H]3CC[C@H]5[C@@]4(CC[C@@H](C5)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O[C@H]8[C@@H]([C@@H]([C@H]([C@@H](O8)C)O)O)O)C)C)O[C@H]([C@@H]1O)C=C(C)C
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity on ADP-mediated platelet activation and aggregation.
Option B: It exhibits inhibitory activity on PAR-1, a thrombin receptor expressed on platelets.
Option C: It exhibits inhibitory activity on proliferation of human peripheral blood lymphocytes.
Option D: It exhibits inhibitory effect on the tube-like formation of human umbilical vein endothelial cells (HUVECs).
"	C
10073779	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(C(=C2C(=C1O)C(=O)C[C@H](O2)C3=C(C=CC(=C3)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)C)O
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity against alpha-glucosidase.
Option B: It exhibits inhibitory activity against HIV protease.
Option C: It exhibits inhibitory activity against aldose reductase.
Option D: It exhibits inhibitory activity against alpha-amylase.
"	C
46184995	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC1=CC2=C(C=C1)N=C3[C@@H]4CCCN4C(=O)C5=CC=CC=C5N3C2=O
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits competitive inhibitory activity on tyrosinase in melanocytes.
Option B: It exhibits inhibitory activity against NF-kappaB.
Option C: It is a potent inhibitor of actin polymerisation and DNA synthesis.
Option D: It exhibits potent inhibitory activity towards mitochondrial NADH oxidase.
"	D
9548906	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@H]1[C@@H]([C@H](O[C@H]1C2=CC3=C(C=C2)OCO3)C4=CC(=C(C=C4)OC)OC)C
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity against production of nitric oxide (NO).
Option B: It exhibits inhibitory effect on the production of nitric oxide (NO).
Option C: It exhibits inhibitory activity on nitric oxide production.
Option D: It exhibits inhibitory effects on production of nitric oxide.
"	A
11313622	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)CN2C(=O)N(SC2=O)C3=CC=CC4=CC=CC=C43
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta).
Option B: It exhibits inhibitory activity on phosphoinositide 3-kinase enzymes (PI3Ks).
Option C: It exhibits inhibitory activity against NF-kappaB.
Option D: It exhibits inhibitory activity against protein kinase C.
"	A
9548905	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@H]1[C@H]([C@@H](O[C@@H]1C2=CC3=C(C=C2)OCO3)C4=CC(=C(C=C4)OC)OC)C
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity on nitric oxide production.
Option B: It exhibits inhibitory effect on the production of nitric oxide (NO).
Option C: It exhibits inhibitory activity against production of nitric oxide (NO).
Option D: It exhibits inhibitory effects on production of nitric oxide.
"	C
46888372	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1C/C=C/[C@@H]([C@H]([C@H](C/C=C/C2=C(C(=CC(=C2)OC)O)C(=O)O1)O)O)O
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity against DNA polymerase and platelet aggregation.
Option B: It exhibits inhibitory activity against chymotrypsin.
Option C: It exhibits inhibitory activity against platelet aggregation.
Option D: It exhibits inhibitory activity against NF-kappaB.
"	D
448042	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity against phospholipase A2 and tyrosinase.
Option B: It exhibits competitive inhibitory activity on tyrosinase in melanocytes.
Option C: It exhibits inhibitory activity against NF-kappaB.
Option D: It has been shown to exhibit inhibitory activity against Rho-associated protein kinase (ROCK) enzyme.
"	D
53952360	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC(=CC=C1CS(=O)(=O)CC2=CC=C(C=C2)O)O
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity against DNA polymerase and platelet aggregation.
Option B: It exhibits inhibitory activity against chymotrypsin.
Option C: It exhibits inhibitory effect on platelet aggregation.
Option D: It exhibits inhibitory activity against platelet aggregation.
"	C
9796181	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CC2=C(C[C@H]1N3C(=CNC3=S)CN)C=C(C=C2F)F
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It inhibits the reuptake transporters of noradrenaline, dopamine, and seratonin.
Option B: It is a potent and selective inhibitor of both bovine and human dopamine beta-hydroxylase.
Option C: It inhibits dopa decarboxylase and depletes animal tissues of norepinephrine.
Option D: It inhibits norepinephrine reuptake by stimulating alpha(2)-adrenergic receptors.
"	B
53355130	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1C/C=C/[C@H]([C@H]([C@H](C/C=C/C2=C(C(=CC(=C2)OC)O)C(=O)O1)O)O)O
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity against platelet aggregation.
Option B: It exhibits inhibitory activity against NF-kappaB.
Option C: It exhibits inhibitory activity against chymotrypsin.
Option D: It exhibits inhibitory activity against DNA polymerase and platelet aggregation.
"	B
10047486	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1[C@H]2[C@@H](NC(=O)[C@@]23[C@@H](/C=C(/C[C@@H](C[C@@H](/C=C/C3=O)O)CO)\\C)C=C1C)CC(C)C
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity on muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites.
Option B: It inhibits excitatory neurotransmission through actions on kainate and AMPA receptors.
Option C: It exhibits inhibitory activity on ADP-mediated platelet activation and aggregation.
Option D: It possesses potent inhibitory activity against HT-29 colonic adenocarcinoma cells.
"	D
4763	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC1(C(=O)NC(=O)NC1=O)C2=CC=CC=C2
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It inhibits excitatory neurotransmission through actions on kainate and AMPA receptors.
Option B: It exhibits inhibitory activity on ADP-mediated platelet activation and aggregation.
Option C: It inhibits calcium channels, resulting in a decrease in excitatory transmitter release.
Option D: It exhibits inhibitory activity on muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites.
"	C
5284627	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(O[C@@H]2CO[C@@]3([C@H]([C@@H]2O1)OC(O3)(C)C)COS(=O)(=O)N)C
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity on ADP-mediated platelet activation and aggregation.
Option B: It inhibits excitatory neurotransmission through actions on kainate and AMPA receptors.
Option C: It exhibits inhibitory activity on muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites.
Option D: It exhibits inhibitory activity on the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes.
"	B
6918296	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)NC4=C(C=CC(=C4)C(F)(F)F)C(F)(F)F)CC[C@@H]5[C@@]3(C=CC(=O)N5)C
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits enzyme inhibitory activity.
Option B: It exhibits biosynthesis inhibitory activity.
Option C: It exhibits carbonic anhydrase inhibitory activity.
Option D: It exhibits dual 5α-reductase inhibitory activity.
"	D
9444	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=NC(=NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits factor Xa inhibitory activity.
Option B: It exhibits dual 5α-reductase inhibitory activity.
Option C: It exhibits DNA methyltransferase inhibitory activity.
Option D: It exhibits carbonic anhydrase inhibitory activity.
"	C
1318	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits metal ion chelation inhibitory activity.
Option B: It exhibits carbonic anhydrase inhibitory activity.
Option C: It exhibits enzyme inhibitory activity.
Option D: It exhibits cellular metabolism inhibitory activity.
"	A
2343	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)CSCC2=NS(=O)(=O)C3=CC(=C(C=C3N2)Cl)S(=O)(=O)N
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits folic acid synthesis inhibitory activity.
Option B: It exhibits Na+/Cl- reabsorption inhibitory activity.
Option C: It exhibits inhibitory activity against NF-kappaB.
Option D: It exhibits inhibitory activity on protein association of L-BMAA.
"	B
2749	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=O)N(C(=C1)C2CCCCC2)O
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits nucleotide synthesis inhibitory activity.
Option B: It exhibits biosynthesis inhibitory activity.
Option C: It exhibits cellular metabolism inhibitory activity.
Option D: It exhibits enzyme inhibitory activity.
"	D
25151352	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC(=NC=C1CC2=CNC3=C2C=C(C=N3)Cl)NCC4=CN=C(C=C4)C(F)(F)F
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity on PAR-1, a thrombin receptor expressed on platelets.
Option B: It exhibits inhibitory activity on ADP-mediated platelet activation and aggregation.
Option C: It exhibits inhibitory effect on the tube-like formation of human umbilical vein endothelial cells (HUVECs).
Option D: It inhibits the colony-stimulating factor (CSF1)/CSF1 receptor pathway.
"	D
9823820	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It inhibits the kinase activities of VEGFR1, VEGFR2, and VEGFR3.
Option B: It selectively inhibits vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3).
Option C: It is a potent inhibitor of FLT3 and AXL tyrosine kinase receptors (IC50 = 0.29 nM and 0.73 nM, respectively).
Option D: Dysidine selectively inhibits human synovial phospholipase A2 (EC 3.1.1.4) with an IC50 = 2.0 muM.
"	A
135398735	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1/C=C/C=C(\\C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)[C@](O4)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)/C=N/N5CCN(CC5)C)/C
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity on DNA-dependent RNA polymerase.
Option B: It inhibits DNA-dependent RNA polymerase activity.
Option C: It exhibits RNA-dependent RNA polymerase inhibitory activity.
Option D: It exhibits inhibitory activity on RNA-dependent RNA polymerase (RdRp) enzyme complex.
"	B
5362129	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2[C@H]3CCC[C@H]3C[C@H]2C(=O)O
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII).
Option B: It exhibits inhibitory activity on muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites.
Option C: It is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII).
Option D: It inhibits excitatory neurotransmission through actions on kainate and AMPA receptors.
"	A
6450551	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=CC=N4
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: Dysidine selectively inhibits human synovial phospholipase A2 (EC 3.1.1.4) with an IC50 = 2.0 muM.
Option B: It is a potent inhibitor of FLT3 and AXL tyrosine kinase receptors (IC50 = 0.29 nM and 0.73 nM, respectively).
Option C: It inhibits the kinase activities of VEGFR1, VEGFR2, and VEGFR3.
Option D: It selectively inhibits vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3).
"	D
312145	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@]4([C@H](OC(=O)C5=COC(=C54)C3=O)COC)C)C
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity against NF-kappaB.
Option B: It exhibits inhibitory activity against chymotrypsin.
Option C: It exhibits inhibitory activity against protein kinase C.
Option D: It exhibits inhibitory activity on phosphoinositide 3-kinase enzymes (PI3Ks).
"	D
10077130	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCOC(=O)N[C@@H]1CC[C@@H]2[C@@H](C1)C[C@@H]3[C@H]([C@H]2/C=C/C4=NC=C(C=C4)C5=CC(=CC=C5)F)[C@H](OC3=O)C
Question about this molecule: Which kind of inhibitory activity does this molecule have/exhibit?
Option A: It exhibits inhibitory activity on ADP-mediated platelet activation and aggregation.
Option B: It exhibits inhibitory activity on PAR-1, a thrombin receptor expressed on platelets.
Option C: It inhibits excitatory neurotransmission through actions on kainate and AMPA receptors.
Option D: It exhibits inhibitory activity on muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites.
"	B
17038	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C=CCC2C1C(=O)N(C2=O)SC(C(Cl)Cl)(Cl)Cl
Question about this molecule: Which kind of irritant is this molecule?
Option A: Inhaled dust irritates the respiratory tract.
Option B: It may severely irritate the eyes and respiratory tract.
Option C: It may irritate the eyes, nose, and respiratory system.
Option D: Inhalation may irritate the respiratory tract.
"	A
6616	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(C2CCC(C2)C1=C)C
Question about this molecule: Which kind of irritant is this molecule?
Option A: It is an irritant to the eyes, nose, and throat in the form of dust and crystals.
Option B: It may result in irritation and burning of the eyes, nose, throat, and skin.
Option C: It results in irritation of the eyes, nasal passages, throat, and lungs.
Option D: It may cause tearing and irritate the eyes, skin, nose, and throat.
"	A
6433396	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1N2CN3CN1C[N+](C2)(C3)C/C=C/Cl.[Cl-]
Question about this molecule: Which kind of irritant is this molecule?
Option A: It causes mild skin irritation.
Option B: It can cause contact dermatitis.
Option C: It causes severe eye irritation and moderate skin irritation.
Option D: It potentially results in skin irritation.
"	B
4122	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CS3
Question about this molecule: What is the mechanism of this molecule's potency?
Option A: It prevents the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling.
Option B: It exerts a protecting effect on neuronal cells through suppressing L-glutamate toxicity.
Option C: It exerts its effect by depolymerising microtubules.
Option D: It disrupts DNA helical structure, induces DNA strand breaks and inhibits bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
"	C
54676228	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=CC=CC=N3
Question about this molecule: What is the mechanism of this molecule's potency?
Option A: It results in simultaneous NF-kappa beta suppression, Heat Shock Transcription Factor 1 (HSF1) suppression and p53 activation, and shows antitumour effects in animal models of various cancers.
Option B: It exerts a protecting effect on neuronal cells through suppressing L-glutamate toxicity.
Option C: It prevents the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling.
Option D: It disrupts DNA helical structure, induces DNA strand breaks and inhibits bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
"	C
5284627	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(O[C@@H]2CO[C@@]3([C@H]([C@@H]2O1)OC(O3)(C)C)COS(=O)(=O)N)C
Question about this molecule: What is the mechanism of this molecule's potency?
Option A: It exerts its effect by depolymerising microtubules.
Option B: It blocks voltage-dependent sodium channels.
Option C: It acts by binding to Smoothened (SMO) receptors and blocking signal transduction.
Option D: It exerts a protecting effect on neuronal cells through suppressing L-glutamate toxicity.
"	B
3002977	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=NN=C(N1C2C[C@H]3CC[C@@H](C2)N3CC[C@@H](C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F)C(C)C
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a chemokine co-receptor 5 antagonist.
Option B: It is a serotonin 3 receptor antagonist.
Option C: It acts as an angiotensin 2 receptor antagonist.
Option D: It acts as an endothelin receptor antagonist.
"	A
9915743	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)/C=C/CN(C)C
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a nucleoside reverse transcriptase inhibitor and cytochrome P450 1A1 inhibitor.
Option B: It is a proton pump inhibitor and cytochrome P450 2C19 inhibitor.
Option C: It is a kinase inhibitor and P-glycoprotein inhibitor.
Option D: It is a HIV protease inhibitor and cytochrome P450 3A inhibitor.
"	C
25077993	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC2=CN(C=N2)CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a Gonadotropin Releasing Hormone Receptor Agonist.
Option B: It works as a Corticosteroid Hormone Receptor Agonist.
Option C: It functions as a Corticosteroid Hormone Receptor Agonist.
Option D: It acts as a Progestational Hormone Receptor Antagonist.
"	A
24775005	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@H]1CN(C[C@@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a Histamine Receptor Antagonist.
Option B: It serves as a Histamine Receptor Antagonist.
Option C: It acts as a Smoothened Receptor Antagonist.
Option D: It serves as a Histamine H1 Receptor Antagonist.
"	C
6005	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CCC2=C3[C@H]1CC4=C(C3=CC=C2)C(=C(C=C4)O)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It functions as a Dopamine Agonist.
Option B: It acts as a dopamine agonist.
Option C: It serves as a dopamine agonist.
Option D: It acts as a dopamine D2 antagonist.
"	A
9924495	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)N2C=C(C=C(C2=O)C3=CC=CC=C3C#N)C4=CC=CC=N4
Question about this molecule: What is the mechanism of this molecule?
Option A: It serves as a Cytochrome P450 3A4 Inducer, Cytochrome P450 1A2 Inducer, Cytochrome P450 2B6 Inducer, Cytochrome P450 2C9 Inducer, and Cytochrome P450 2C19 Inducer.
Option B: It is a Cytochrome P450 3A Inhibitor, P-Glycoprotein Inhibitor, Cytochrome P450 1A2 Inhibitor, Cytochrome P450 2C9 Inhibitor, and Cytochrome P450 2D6 Inhibitor.
Option C: It works as a Cytochrome P450 2C19 Inhibitor, Cytochrome P450 2C9 Inhibitor, Cytochrome P450 3A4 Inducer, and Cytochrome P450 2D6 Inducer.
Option D: It serves as an AMPA Receptor Antagonist, UGT2B7 Inhibitor, UGT1A9 Inhibitor, Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C8 Inhibitor.
"	D
4197	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2
Question about this molecule: What is the mechanism of this molecule?
Option A: It serves as a phosphodiesterase 5 inhibitor.
Option B: It serves as a phosphodiesterase 3 inhibitor.
Option C: It acts as a phosphodiesterase 3 inhibitor.
Option D: It acts as a cholinesterase inhibitor.
"	B
9931954	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=C3C(=CC(=C4)F)N2
Question about this molecule: What is the mechanism of this molecule?
Option A: It serves as a poly(ADP-ribose) polymerase inhibitor.
Option B: It serves as a cytochrome P450 2D6 inhibitor.
Option C: It serves as a histone deacetylase inhibitor and cytochrome P450 2D6 inhibitor.
Option D: It serves as a factor Xa inhibitor.
"	A
441074	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC1=CC2=C(C=CN=C2C=C1)[C@@H]([C@H]3C[C@@H]4CCN3C[C@@H]4C=C)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a cytochrome P450 2C9 inhibitor.
Option B: It is a proton pump inhibitor and cytochrome P450 2C19 inhibitor.
Option C: It acts as a P2Y12 receptor antagonist and a cytochrome P450 2C8 inhibitor.
Option D: It serves as a cytochrome P450 2D6 inhibitor.
"	D
5277135	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)[C@@H](CO)N1C=C(C(=O)C2=C1C=C(C(=C2)CC3=C(C(=CC=C3)Cl)F)OC)C(=O)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It serves as an HIV integrase inhibitor and cytochrome P450 2C9 inducer.
Option B: It acts as a P2Y12 receptor antagonist and a cytochrome P450 2C8 inhibitor.
Option C: It serves as a histone deacetylase inhibitor and cytochrome P450 2D6 inhibitor.
Option D: It serves as a cytochrome P450 2D6 inhibitor.
"	A
3042	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2
Question about this molecule: What is the mechanism of this molecule?
Option A: It has a cholinergic antagonist mechanism of action.
Option B: It acts as a cholinergic antagonist.
Option C: It functions as a cholinergic muscarinic antagonist.
Option D: It serves as a cholinergic antagonist.
"	D
11450633	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCC[C@H](C3)N
Question about this molecule: What is the mechanism of this molecule?
Option A: It serves as a dipeptidyl peptidase 4 inhibitor.
Option B: It acts as a Dipeptidase Inhibitor.
Option C: It inhibits dipeptidyl peptidase 4.
Option D: It is a Dipeptidyl Peptidase 4 Inhibitor.
"	A
55283	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@H]5CO[C@](O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a calcium channel antagonist, cytochrome P450 3A4 inhibitor, cytochrome P450 3A inhibitor, and P-glycoprotein inhibitor.
Option B: It serves as a neurokinin 1 antagonist, cytochrome P450 2D6 inhibitor, breast cancer resistance protein inhibitor, and P-glycoprotein inhibitor.
Option C: It serves as a cytochrome P450 3A4 inhibitor, P-glycoprotein inhibitor, and breast cancer resistance protein inhibitor.
Option D: It has a non-nucleoside reverse transcriptase inhibitor, cytochrome P450 3A inducer, cytochrome P450 2C9 inhibitor, cytochrome P450 2C19 inhibitor, and P-glycoprotein inhibitor mechanism of action.
"	C
10184665	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC(=C(C(=C1)Cl)COCCOCCCCCCNC[C@@H](C2=CC(=C(C=C2)O)CO)O)Cl
Question about this molecule: What is the mechanism of this molecule?
Option A: It works as an Adrenergic alpha2-Agonist.
Option B: It acts as an Adrenergic beta2-Agonist.
Option C: It is an Adrenergic beta3-Agonist.
Option D: It acts as an Adrenergic beta-Agonist.
"	B
6918485	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@H](C1=NC(=CS1)C2=CC=C(C=C2)C#N)[C@](CN3C=NC=N3)(C4=C(C=CC(=C4)F)F)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It acts as a Cytochrome P450 3A Inhibitor, P-Glycoprotein Inhibitor, Cytochrome P450 2D6 Inhibitor, and Organic Cation Transporter 2 Inhibitor.
Option B: It acts as a Tyrosine Kinase Inhibitor, Cytochrome P450 3A Inhibitor, and Cytochrome P450 2C9 Inhibitor.
Option C: It acts as a Cytochrome P450 3A4 Inhibitor, Organic Cation Transporter 2 Inhibitor, and P-Glycoprotein Inhibitor.
Option D: It acts as a Chloride Channel Activation Potentiator, Cytochrome P450 2C9 Inhibitor, P-Glycoprotein Inhibitor, and Cytochrome P450 3A Inhibitor.
"	C
6918248	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CN(CCN1CCN2C3=CC=CC=C3NC2=O)C4=CC=CC(=C4)C(F)(F)F
Question about this molecule: What is the mechanism of this molecule?
Option A: It activates 5-HT1D receptors on intracranial blood vessels, leading to vasoconstriction, and activates 5-HT1D receptors on sensory nerve endings of the trigeminal system, resulting in the inhibition of pro-inflammatory neuropeptide release.
Option B: It has a high affinity for 5-HTA1 and 5-HTA2 receptors, displaying agonist activity on 5-HTA1 and antagonist on 5-HTA2, resulting in lowering of serotonin in the brain as well as an effect on increasing norepinephrine and dopamine neurotransmitters.
Option C: It inhibits serotonin reuptake, acts as a partial agonist of the 5-HT1B receptor, an agonist of 5-HT1A, and an antagonist of the 5-HT3, 5-HT1D, and 5-HT7 receptors.
Option D: It acts as a cytochrome P450 3A inhibitor, P-glycoprotein inhibitor, cytochrome P450 2D6 inhibitor, organic anion transporting polypeptide 1B1 inhibitor, organic anion transporting polypeptide 1B3 inhibitor, breast cancer resistance protein inhibitor, and multidrug and toxin extrusion transporter 1 inhibitor.
"	B
1775	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)C2(C(=O)NC(=O)N2)C3=CC=CC=C3
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a Cytochrome P450 3A Inhibitor, P-Glycoprotein Inhibitor, Cytochrome P450 1A2 Inhibitor, Cytochrome P450 2C9 Inhibitor, and Cytochrome P450 2D6 Inhibitor.
Option B: It acts as a Cytochrome P450 1A2 Inducer, Cytochrome P450 2B6 Inducer, Cytochrome P450 2C8 Inducer, Cytochrome P450 2C19 Inducer, Cytochrome P450 2D6 Inducer, Cytochrome P450 3A Inducer, and Cytochrome P450 2C9 Inducer.
Option C: It works as a Cytochrome P450 2C19 Inhibitor, Cytochrome P450 2C9 Inhibitor, Cytochrome P450 3A4 Inducer, and Cytochrome P450 2D6 Inducer.
Option D: It serves as a Cytochrome P450 3A4 Inducer, Cytochrome P450 1A2 Inducer, Cytochrome P450 2B6 Inducer, Cytochrome P450 2C9 Inducer, and Cytochrome P450 2C19 Inducer.
"	B
3749	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5
Question about this molecule: What is the mechanism of this molecule?
Option A: It acts as an endothelin receptor antagonist.
Option B: It functions as an angiotensin 2 receptor antagonist.
Option C: It acts as an angiotensin 2 receptor antagonist.
Option D: It is an angiotensin 2 type 1 receptor antagonist.
"	C
446596	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]([C@H]1[C@@H](O1)C[C@H]2CO[C@H]([C@@H]([C@@H]2O)O)C/C(=C/C(=O)OCCCCCCCCC(=O)O)/C)[C@H](C)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It acts as a Proteasome Inhibitor.
Option B: It is a RNA Synthetase Inhibitor.
Option C: It acts as a Lipase Inhibitor.
Option D: It works as a Proteasome Inhibitor.
"	B
2159	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCN1CCCC1CNC(=O)C2=CC(=C(C=C2OC)N)S(=O)(=O)CC
Question about this molecule: What is the mechanism of this molecule?
Option A: It acts as a dopamine D2 antagonist.
Option B: It serves as a dopamine agonist.
Option C: It functions as a Dopamine Agonist.
Option D: It acts as a dopamine agonist.
"	A
77993	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CCC[C@@H]1CC2=CNC3=C2C=C(C=C3)CCS(=O)(=O)C4=CC=CC=C4
Question about this molecule: What is the mechanism of this molecule?
Option A: It functions as a Serotonin 1b Receptor Agonist and Serotonin 1d Receptor Agonist.
Option B: It acts as a Serotonin Uptake Inhibitor.
Option C: It is a serotonin 1b receptor agonist and serotonin 1d receptor agonist.
Option D: It acts as a Serotonin 4 Receptor Agonist.
"	C
214348	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C(=C1)C2=NN(C(=N2)C3=CC=CC=C3O)C4=CC=C(C=C4)C(=O)O)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a Cytochrome P450 3A Inhibitor, P-Glycoprotein Inhibitor, Cytochrome P450 1A2 Inhibitor, Cytochrome P450 2C9 Inhibitor, and Cytochrome P450 2D6 Inhibitor.
Option B: It is an Iron Chelating Activity, Cytochrome P450 3A4 Inducer, Cytochrome P450 2C8 Inhibitor, and Cytochrome P450 1A2 Inhibitor.
Option C: It works as a Cytochrome P450 2C19 Inhibitor, Cytochrome P450 2C9 Inhibitor, Cytochrome P450 3A4 Inducer, and Cytochrome P450 2D6 Inducer.
Option D: It serves as a Cytochrome P450 3A4 Inducer, Cytochrome P450 1A2 Inducer, Cytochrome P450 2B6 Inducer, Cytochrome P450 2C9 Inducer, and Cytochrome P450 2C19 Inducer.
"	B
6918296	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)NC4=C(C=CC(=C4)C(F)(F)F)C(F)(F)F)CC[C@@H]5[C@@]3(C=CC(=O)N5)C
Question about this molecule: What is the mechanism of this molecule?
Option A: It serves as a 5-alpha Reductase Inhibitor.
Option B: It acts as a Lipase Inhibitor.
Option C: It is a 5-alpha Reductase Inhibitor.
Option D: It works as a Proteasome Inhibitor.
"	C
9871419	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCSC1=NC(=C2C(=N1)N(N=N2)[C@@H]3C[C@@H]([C@H]([C@H]3O)O)OCCO)N[C@@H]4C[C@H]4C5=CC(=C(C=C5)F)F
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a Calcineurin Inhibitor, Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor.
Option B: It is an Orexin Receptor Antagonist, P-Glycoprotein Inhibitor, and Cytochrome P450 3A Inhibitor.
Option C: It is a P2Y12 Receptor Antagonist, Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor.
Option D: It acts as a Protein Kinase Inhibitor, Cytochrome P450 1A2 Inhibitor, and P-Glycoprotein Inhibitor.
"	C
3152	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC
Question about this molecule: What is the mechanism of this molecule?
Option A: It serves as a cholinergic antagonist.
Option B: It functions as a cholinergic muscarinic antagonist.
Option C: It acts as a cholinesterase inhibitor.
Option D: It acts as a cholinergic antagonist.
"	C
9887712	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)Cl
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a Sodium-Glucose Transporter 2 Inhibitor.
Option B: It acts as a Proton Pump Inhibitor.
Option C: It functions as a Proton Pump Inhibitor.
Option D: It acts as a Lipase Inhibitor.
"	A
3478	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CN=C(C=N1)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3
Question about this molecule: What is the mechanism of this molecule?
Option A: It stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.
Option B: It can decrease intracellular calcium levels by inhibiting calcium influx through voltage-gated calcium channels.
Option C: It alters signal conduction in neurons by blocking fast voltage-gated sodium (Na+) channels in the neuronal cell membrane responsible for signal propagation.
Option D: It inhibits repeated neuronal firing and stabilizes the inactivated state of voltage-gated sodium channels.
"	A
4829	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
Question about this molecule: What is the mechanism of this molecule?
Option A: It serves as an AMPA Receptor Antagonist, UGT2B7 Inhibitor, UGT1A9 Inhibitor, Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C8 Inhibitor.
Option B: It is a Kinase Inhibitor, Cytochrome P450 2C9 Inhibitor, Breast Cancer Resistance Protein Inhibitor, UGT1A9 Inhibitor, and UGT1A1 Inhibitor.
Option C: It acts as a Thrombopoietin Receptor Agonist, Organic Anion Transporting Polypeptide 1B1 Inhibitor, Breast Cancer Resistance Protein Inhibitor, UGT1A1 Inhibitor, UGT1A3 Inhibitor, UGT1A4 Inhibitor, UGT1A6 Inhibitor, UGT1A9 Inhibitor, UGT2B7 Inhibitor, and UGT2B15 Inhibitor.
Option D: It is a Peroxisome Proliferator-activated Receptor alpha Agonist and Peroxisome Proliferator-activated Receptor gamma Agonist.
"	D
2099	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(N=CN1)CN2CCC3=C(C2=O)C4=CC=CC=C4N3C
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a serotonin 3 receptor antagonist.
Option B: It inhibits serotonin uptake.
Option C: It acts as a Serotonin Uptake Inhibitor.
Option D: It works as a serotonin uptake inhibitor.
"	A
134018	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(SC(=N1)C2=CC(=C(C=C2)OCC(C)C)C#N)C(=O)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It serves as a cytochrome P450 2D6 inhibitor.
Option B: It functions as a xanthine oxidase inhibitor.
Option C: It inhibits xanthine oxidase.
Option D: It is a cytochrome P450 2C9 inhibitor.
"	C
11561674	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCOC1=C(C=CC(=C1)[C@@H](CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC
Question about this molecule: What is the mechanism of this molecule?
Option A: It inhibits phosphodiesterase 4.
Option B: It inhibits Phosphodiesterase 3.
Option C: It inhibits Phosphodiesterase 5.
Option D: It acts as a Phosphodiesterase 4 Inhibitor.
"	A
3348	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)(C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O)C(=O)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It antagonizes smoothened receptors.
Option B: It antagonizes adenosine A3 receptors.
Option C: It antagonizes histamine H1 receptors.
Option D: It antagonizes histamine H2 receptors.
"	C
10324367	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1([C@@H]2[C@H]1[C@H](N(C2)C(=O)[C@H](C(C)(C)C)NC(=O)NC(C)(C)C)C(=O)NC(CC3CCC3)C(=O)C(=O)N)C
Question about this molecule: What is the mechanism of this molecule?
Option A: It inhibits HCV NS3/4A protease, cytochrome P450 3A4, and cytochrome P450 3A5.
Option B: It acts as a non-nucleoside reverse transcriptase inhibitor, cytochrome P450 3A inducer, cytochrome P450 2B6 inducer, cytochrome P450 2C9 inhibitor, cytochrome P450 2C19 inhibitor, and cytochrome P450 3A4 inhibitor.
Option C: It inhibits Bcr-Abl tyrosine kinase, cytochrome P450 2C8, cytochrome P450 2D6, and UGT1A1, and it induces cytochrome P450 2B6 and cytochrome P450 2C8, and it inhibits P-glycoprotein.
Option D: It inhibits Bcr-Abl tyrosine kinase, cytochrome P450 3A4, and cytochrome P450 2D6.
"	A
6451149	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC=CC=C1C2=CC(=NC=C2N(C)C(=O)C(C)(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CCN(CC4)C
Question about this molecule: What is the mechanism of this molecule?
Option A: It serves as a neurokinin 1 antagonist, cytochrome P450 2D6 inhibitor, breast cancer resistance protein inhibitor, and P-glycoprotein inhibitor.
Option B: It is a calcium channel antagonist, cytochrome P450 3A4 inhibitor, cytochrome P450 3A inhibitor, and P-glycoprotein inhibitor.
Option C: It antagonizes neurokinin 1 receptors, cytochrome P450 3A4, P-glycoprotein, and breast cancer resistance protein.
Option D: It serves as a cytochrome P450 3A4 inhibitor, P-glycoprotein inhibitor, and breast cancer resistance protein inhibitor.
"	C
24826799	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
Question about this molecule: What is the mechanism of this molecule?
Option A: It inhibits protein synthesis.
Option B: It inhibits Janus kinase.
Option C: It inhibits kinases.
Option D: It inhibits protein kinase.
"	D
6918554	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC1=C(C=C2CC(CC2=C1)NC[C@@H](C3=C4C=CC(=O)NC4=C(C=C3)O)O)CC
Question about this molecule: What is the mechanism of this molecule?
Option A: It works as an Adrenergic alpha2-Agonist.
Option B: It acts as an Adrenergic beta-Agonist.
Option C: It acts as an Adrenergic beta2-Agonist.
Option D: It is an Adrenergic beta3-Agonist.
"	C
11243969	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1[C@@H]2C[C@@H]2N([C@@H]1C#N)C(=O)[C@H](C34CC5CC(C3)CC(C5)(C4)O)N
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a Dipeptidyl Peptidase 4 Inhibitor.
Option B: It inhibits dipeptidyl peptidase 4.
Option C: It serves as a dipeptidyl peptidase 4 inhibitor.
Option D: It acts as a Dipeptidase Inhibitor.
"	B
2343	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)CSCC2=NS(=O)(=O)C3=CC(=C(C=C3N2)Cl)S(=O)(=O)N
Question about this molecule: What is the mechanism of this molecule?
Option A: The hypotensive effects are not necessarily due to its diuretic activity.
Option B: It mimics epilepsy by blocking the inhibitory action of GABA receptors.
Option C: It modulates neurotransmission to treat pharmacoresistant seizures.
Option D: It alters signal conduction in neurons by blocking fast voltage-gated sodium (Na+) channels in the neuronal cell membrane responsible for signal propagation.
"	A
9966051	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=C(C=C1)SC2=CC=CC=C2N3CCNCC3)C
Question about this molecule: What is the mechanism of this molecule?
Option A: It inhibits serotonin reuptake, acts as a partial agonist of the 5-HT1B receptor, an agonist of 5-HT1A, and an antagonist of the 5-HT3, 5-HT1D, and 5-HT7 receptors.
Option B: It activates 5-HT1D receptors on intracranial blood vessels, leading to vasoconstriction, and activates 5-HT1D receptors on sensory nerve endings of the trigeminal system, resulting in the inhibition of pro-inflammatory neuropeptide release.
Option C: It has a high affinity for 5-HTA1 and 5-HTA2 receptors, displaying agonist activity on 5-HTA1 and antagonist on 5-HTA2, resulting in lowering of serotonin in the brain as well as an effect on increasing norepinephrine and dopamine neurotransmitters.
Option D: It acts as a cytochrome P450 3A inhibitor, P-glycoprotein inhibitor, cytochrome P450 2D6 inhibitor, organic anion transporting polypeptide 1B1 inhibitor, organic anion transporting polypeptide 1B3 inhibitor, breast cancer resistance protein inhibitor, and multidrug and toxin extrusion transporter 1 inhibitor.
"	A
49846579	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN=C8C(=C7)C=CN8)C
Question about this molecule: What is the mechanism of this molecule?
Option A: It inhibits P-glycoprotein.
Option B: It inhibits Glucosylceramide Synthase, P-Glycoprotein, and Cytochrome P450 2D6.
Option C: It inhibits sodium-glucose transporter 2 and P-glycoprotein.
Option D: It inhibits Microsomal Triglyceride Transfer Protein, Cytochrome P450 3A4, and P-Glycoprotein.
"	A
2754	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4
Question about this molecule: What is the mechanism of this molecule?
Option A: It serves as a phosphodiesterase 3 inhibitor.
Option B: It serves as a phosphodiesterase 5 inhibitor.
Option C: It acts as a cholinesterase inhibitor.
Option D: It acts as a phosphodiesterase 3 inhibitor.
"	D
135401907	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=NNC2=C1C(=O)NC=N2
Question about this molecule: What is the mechanism of this molecule?
Option A: It serves as a cytochrome P450 2D6 inhibitor.
Option B: It is a cytochrome P450 2C9 inhibitor.
Option C: It functions as a xanthine oxidase inhibitor.
Option D: It inhibits xanthine oxidase.
"	C
2092	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN(CCCNC(=O)C1CCCO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
Question about this molecule: What is the mechanism of this molecule?
Option A: It acts as an Adrenergic alpha-Antagonist.
Option B: It acts as an Adrenergic alpha1-Agonist.
Option C: It functions as an Adrenergic beta-Antagonist.
Option D: It works as an Adrenergic alpha2-Agonist.
"	A
5311068	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(C(=CC=C1)[C@H](C)C2=CN=CN2)C
Question about this molecule: What is the mechanism of this molecule?
Option A: It works as an Adrenergic alpha2-Agonist.
Option B: It acts as an Adrenergic alpha1-Agonist.
Option C: It is an Adrenergic alpha2-Agonist.
Option D: It acts as an Adrenergic beta2-Agonist.
"	C
11626560	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
Question about this molecule: What is the mechanism of this molecule?
Option A: It serves as a Farnesyltransferase Inhibitor, Cytochrome P450 2C8 Inhibitor, Cytochrome P450 3A Inhibitor, P-Glycoprotein Inhibitor, Cytochrome P450 2C19 Inhibitor, Organic Anion Transporting Polypeptide 1B1 Inhibitor, Organic Anion Transporting Polypeptide 1B3 Inhibitor, and Breast Cancer Resistance Protein Inhibitor.
Option B: It is a Cytochrome P450 3A Inhibitor, Receptor Tyrosine Kinase Inhibitor, Cytochrome P450 2B6 Inhibitor, P-Glycoprotein Inhibitor, Organic Cation Transporter 1 Inhibitor, and Organic Cation Transporter 2 Inhibitor.
Option C: It acts as a Protein Kinase Inhibitor, Cytochrome P450 3A4 Inducer, Cytochrome P450 2B6 Inducer, Cytochrome P450 2C8 Inducer, Cytochrome P450 2C9 Inducer, Cytochrome P450 2C19 Inducer, Organic Anion Transporting Polypeptide 1B1 Inhibitor, Organic Anion Transporting Polypeptide 1B3 Inhibitor, Organic Anion Transporter 1 Inhibitor, Organic Anion Transporter 3 Inhibitor, and Breast Cancer Resistance Protein Inhibitor.
Option D: It acts as a Kinase Inhibitor, Cytochrome P450 3A Inducer, P-Glycoprotein Inducer, Cytochrome P450 2B6 Inducer, Organic Cation Transporter 1 Inhibitor, Organic Anion Transporter 3 Inhibitor, Multidrug and Toxin Extrusion Transporter 1 Inhibitor, and Breast Cancer Resistance Protein Inhibitor.
"	B
3081361	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a Protein Kinase Inhibitor.
Option B: It works as a Proteasome Inhibitor.
Option C: It works as a Protein Kinase Inhibitor.
Option D: It acts as a Lipase Inhibitor.
"	A
123631	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4
Question about this molecule: What is the mechanism of this molecule?
Option A: It works as a Proteasome Inhibitor.
Option B: It works as a Protein Kinase Inhibitor.
Option C: It acts as a Lipase Inhibitor.
Option D: It is a Protein Kinase Inhibitor.
"	D
5719	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCN(C1=CC=CC(=C1)C2=CC=NC3=C(C=NN23)C#N)C(=O)C
Question about this molecule: What is the mechanism of this molecule?
Option A: It acts as a Competitive Opioid Antagonist and Partial Opioid Agonist.
Option B: It acts as a Partial Opioid Agonist.
Option C: It is a Full Opioid Agonist.
Option D: It is a GABA A Agonist.
"	D
11707110	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5
Question about this molecule: What is the mechanism of this molecule?
Option A: It acts as a Lipase Inhibitor.
Option B: It works as a Protein Kinase Inhibitor.
Option C: It is a Protein Kinase Inhibitor.
Option D: It works as a Proteasome Inhibitor.
"	C
15951529	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(C(=O)N(C(=S)N1C2=CC(=C(C=C2)C(=O)NC)F)C3=CC(=C(C=C3)C#N)C(F)(F)F)C
Question about this molecule: What is the mechanism of this molecule?
Option A: It is an androgen receptor antagonist, cytochrome P450 3A4 inducer, cytochrome P450 2C9 inducer, and cytochrome P450 2C19 inducer.
Option B: It inhibits Bcr-Abl tyrosine kinase, cytochrome P450 3A4, and cytochrome P450 2D6.
Option C: It functions as an endothelin receptor antagonist, cytochrome P450 3A inducer, and cytochrome P450 2C9 inducer.
Option D: It inhibits HCV NS3/4A protease, cytochrome P450 3A4, and cytochrome P450 3A5.
"	A
9913767	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)N(CCCCOCC(=O)NS(=O)(=O)C)C1=CN=C(C(=N1)C2=CC=CC=C2)C3=CC=CC=C3
Question about this molecule: What is the mechanism of this molecule?
Option A: It serves as a prostaglandin receptor agonist.
Option B: It is a receptor agonist.
Option C: It is a prostacyclin receptor agonist.
Option D: It acts as a melatonin receptor agonist.
"	C
5284549	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCN[C@H]1C[C@@H](S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)C
Question about this molecule: What is the mechanism of this molecule?
Option A: It acts as a Dipeptidase Inhibitor.
Option B: It serves as a Carbonic Anhydrase Inhibitor.
Option C: It acts as a Carbonic Anhydrase Inhibitor and P-Glycoprotein Inhibitor.
Option D: It is a Carbonic Anhydrase Inhibitor.
"	B
5287969	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CC[C@@H]([C@@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It alters signal conduction in neurons by blocking fast voltage-gated sodium (Na+) channels in the neuronal cell membrane responsible for signal propagation.
Option B: It inhibits cyclin-dependent kinases, arresting cell division and causing apoptosis in non-small lung cancer cells.
Option C: It inhibits urate crystal deposition, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes.
Option D: It inhibits essential PBPs, resulting in impaired cell wall homeostasis, loss of cell integrity, and bacterial cell death.
"	B
24776445	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a Histamine Receptor Antagonist.
Option B: It serves as a Histamine H1 Receptor Antagonist.
Option C: It acts as a Smoothened Receptor Antagonist.
Option D: It serves as a Histamine Receptor Antagonist.
"	C
5360515	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CC1CN2CC[C@]34[C@@H]5C(=O)CC[C@]3([C@H]2CC6=C4C(=C(C=C6)O)O5)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It acts as a Competitive Opioid Antagonist and Partial Opioid Agonist.
Option B: It acts as an Opioid Antagonist.
Option C: It acts as a Partial Opioid Agonist.
Option D: It acts as an Opioid mu-Receptor Agonist.
"	B
24822371	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CNC1=CC=C(C=C1)/C=C/C2=CN=C(C=C2)OCCOCCOCC[18F]
Question about this molecule: What is the mechanism of this molecule?
Option A: It exhibits Magnetic Resonance Contrast Activity.
Option B: It has ultrasound contrast activity.
Option C: It has a positron emitting activity mechanism.
Option D: It exhibits positron emitting activity.
"	D
104865	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=NC=CC=N3)OCCO)OC4=CC=CC=C4OC
Question about this molecule: What is the mechanism of this molecule?
Option A: It is an androgen receptor antagonist, cytochrome P450 3A4 inducer, cytochrome P450 2C9 inducer, and cytochrome P450 2C19 inducer.
Option B: It functions as an endothelin receptor antagonist, cytochrome P450 3A inducer, and cytochrome P450 2C9 inducer.
Option C: It inhibits HCV NS3/4A protease, cytochrome P450 3A4, and cytochrome P450 3A5.
Option D: It inhibits Bcr-Abl tyrosine kinase, cytochrome P450 3A4, and cytochrome P450 2D6.
"	B
2267	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CCCC(CC1)N2C(=O)C3=CC=CC=C3C(=N2)CC4=CC=C(C=C4)Cl
Question about this molecule: What is the mechanism of this molecule?
Option A: It serves as a Histamine Receptor Antagonist.
Option B: It serves as a Histamine H1 Receptor Antagonist.
Option C: It is a Histamine H1 Receptor Antagonist.
Option D: It is a Histamine Receptor Antagonist.
"	C
19371515	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CCC(=C2C3=CC=CC=C3CCN4C2=NC=C4C=O)CC1
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a Histamine H1 Receptor Antagonist.
Option B: It serves as a Histamine H1 Receptor Antagonist.
Option C: It is a Histamine Receptor Antagonist.
Option D: It serves as a Histamine Receptor Antagonist.
"	A
150311	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC(=CC=C1[C@@H]2[C@H](C(=O)N2C3=CC=C(C=C3)F)CC[C@@H](C4=CC=C(C=C4)F)O)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It serves as a neurokinin 1 antagonist, cytochrome P450 2D6 inhibitor, breast cancer resistance protein inhibitor, and P-glycoprotein inhibitor.
Option B: It antagonizes neurokinin 1 receptors, cytochrome P450 3A4, P-glycoprotein, and breast cancer resistance protein.
Option C: It serves as a cytochrome P450 3A4 inhibitor, P-glycoprotein inhibitor, and breast cancer resistance protein inhibitor.
Option D: It acts on the sterol transporter Niemann-Pick C1-Like 1 (NPC1L1) and does not affect the absorption of fat-soluble nutrients.
"	D
25151352	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC(=NC=C1CC2=CNC3=C2C=C(C=N3)Cl)NCC4=CN=C(C=C4)C(F)(F)F
Question about this molecule: What is the mechanism of this molecule?
Option A: It inhibits the colony-stimulating factor (CSF1)/CSF1 receptor pathway as a selective tyrosine kinase inhibitor.
Option B: It has a non-nucleoside reverse transcriptase inhibitor, cytochrome P450 3A inducer, cytochrome P450 2C9 inhibitor, cytochrome P450 2C19 inhibitor, and P-glycoprotein inhibitor mechanism of action.
Option C: It serves as a neurokinin 1 antagonist, cytochrome P450 2D6 inhibitor, breast cancer resistance protein inhibitor, and P-glycoprotein inhibitor.
Option D: It serves as a cytochrome P450 3A4 inhibitor, P-glycoprotein inhibitor, and breast cancer resistance protein inhibitor.
"	A
11434515	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C[N+]2(CCC1[C@H](C2)OC(=O)C(C3=CC=CS3)(C4=CC=CS4)O)CCCOC5=CC=CC=C5
Question about this molecule: What is the mechanism of this molecule?
Option A: It serves as a cholinergic antagonist.
Option B: It has a cholinergic antagonist mechanism of action.
Option C: It functions as a cholinergic muscarinic antagonist.
Option D: It acts as a cholinergic antagonist.
"	D
16004692	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br
Question about this molecule: What is the mechanism of this molecule?
Option A: It functions as an angiotensin 2 receptor antagonist.
Option B: It acts as an endothelin receptor antagonist.
Option C: It is an angiotensin 2 type 1 receptor antagonist.
Option D: It acts as an angiotensin 2 receptor antagonist.
"	B
132999	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)C[C@H]3CC4=CC(=C(C=C34)OC)OC
Question about this molecule: What is the mechanism of this molecule?
Option A: It antagonizes hyperpolarization-activated cyclic nucleotide-gated channels.
Option B: It alters signal conduction in neurons by blocking fast voltage-gated sodium (Na+) channels in the neuronal cell membrane responsible for signal propagation.
Option C: It mimics epilepsy by blocking the inhibitory action of GABA receptors.
Option D: It inhibits repeated neuronal firing and stabilizes the inactivated state of voltage-gated sodium channels.
"	A
44462760	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F
Question about this molecule: What is the mechanism of this molecule?
Option A: It serves as a Farnesyltransferase Inhibitor, Cytochrome P450 2C8 Inhibitor, Cytochrome P450 3A Inhibitor, P-Glycoprotein Inhibitor, Cytochrome P450 2C19 Inhibitor, Organic Anion Transporting Polypeptide 1B1 Inhibitor, Organic Anion Transporting Polypeptide 1B3 Inhibitor, and Breast Cancer Resistance Protein Inhibitor.
Option B: It acts as a Protein Kinase Inhibitor, Cytochrome P450 3A4 Inducer, Cytochrome P450 2B6 Inducer, Cytochrome P450 2C8 Inducer, Cytochrome P450 2C9 Inducer, Cytochrome P450 2C19 Inducer, Organic Anion Transporting Polypeptide 1B1 Inhibitor, Organic Anion Transporting Polypeptide 1B3 Inhibitor, Organic Anion Transporter 1 Inhibitor, Organic Anion Transporter 3 Inhibitor, and Breast Cancer Resistance Protein Inhibitor.
Option C: It acts as a Kinase Inhibitor, Cytochrome P450 3A Inducer, P-Glycoprotein Inducer, Cytochrome P450 2B6 Inducer, Organic Cation Transporter 1 Inhibitor, Organic Anion Transporter 3 Inhibitor, Multidrug and Toxin Extrusion Transporter 1 Inhibitor, and Breast Cancer Resistance Protein Inhibitor.
Option D: It is a Cytochrome P450 3A Inhibitor, Receptor Tyrosine Kinase Inhibitor, Cytochrome P450 2B6 Inhibitor, P-Glycoprotein Inhibitor, Organic Cation Transporter 1 Inhibitor, and Organic Cation Transporter 2 Inhibitor.
"	B
5284566	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1[C@@H]2CCC[C@H]1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a serotonin 3 receptor antagonist.
Option B: It works as a serotonin uptake inhibitor.
Option C: It inhibits serotonin uptake.
Option D: It acts as a Serotonin Uptake Inhibitor.
"	A
28417	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC5=C(C[C@]34C)C=NO5
Question about this molecule: What is the mechanism of this molecule?
Option A: It is an Estrogen Receptor Agonist.
Option B: It is an Androgen Receptor Agonist.
Option C: It acts as an Androgen Receptor Antagonist.
Option D: It works as an Estrogen Receptor Agonist.
"	B
5311309	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)C1CCC(CC1)C(=O)N[C@H](CC2=CC=CC=C2)C(=O)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It opens Potassium Channels.
Option B: It acts as a Potassium Channel Antagonist.
Option C: It inhibits DNA Polymerase.
Option D: It functions as a DNA Polymerase Inhibitor.
"	B
135409400	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C2=C(C=CC(=C2Cl)Cl)N=C3N1CC(=O)N3
Question about this molecule: What is the mechanism of this molecule?
Option A: It acts as a Phosphodiesterase 4 Inhibitor.
Option B: It inhibits Phosphodiesterase 3.
Option C: It is a Phosphodiesterase 5 Inhibitor.
Option D: It inhibits Phosphodiesterase 5.
"	B
3033538	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC=CC=C1N2CCN(CC2)CCC3=NN=C4N3CCCC4
Question about this molecule: What is the mechanism of this molecule?
Option A: It agonizes Adrenergic alpha receptors.
Option B: It acts as an Adrenergic alpha1-Agonist.
Option C: It works as an Adrenergic alpha2-Agonist.
Option D: It antagonizes Adrenergic alpha receptors.
"	D
5464096	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@H](C(=O)N1[C@H]2CCC[C@H]2C[C@H]1C(=O)O)N[C@@H](CCC3=CC=CC=C3)C(=O)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It works as an Angiotensin 2 Receptor Antagonist.
Option B: It has an angiotensin-converting enzyme inhibitor mechanism of action.
Option C: It works as an Angiotensin-converting Enzyme Inhibitor.
Option D: It inhibits angiotensin-converting enzyme.
"	D
2216	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CN=C(N1)NC2=C(C=C(C=C2Cl)N)Cl
Question about this molecule: What is the mechanism of this molecule?
Option A: It agonizes Adrenergic alpha receptors.
Option B: It acts as an Adrenergic alpha1-Agonist.
Option C: It works as an Adrenergic alpha2-Agonist.
Option D: It antagonizes Adrenergic alpha receptors.
"	A
9823820	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl
Question about this molecule: What is the mechanism of this molecule?
Option A: It serves as a Serotonin Uptake Inhibitor.
Option B: It acts as a Serotonin Uptake Inhibitor.
Option C: It inhibits Receptor Tyrosine Kinase.
Option D: It acts as a Bcr-Abl Tyrosine Kinase Inhibitor.
"	C
135398735	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1/C=C/C=C(\\C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)[C@](O4)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)/C=N/N5CCN(CC5)C)/C
Question about this molecule: What is the mechanism of this molecule?
Option A: It inhibits DNA Polymerase.
Option B: It inhibits DNA-dependent RNA polymerase.
Option C: It inhibits topoisomerase.
Option D: It functions as a DNA Polymerase Inhibitor.
"	B
2369	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)NCC(COC1=CC=C(C=C1)CCOCC2CC2)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It is an adrenergic beta-antagonist.
Option B: It is an adrenergic alpha-agonist.
Option C: It serves as an adrenergic alpha-agonist.
Option D: It serves as an adrenergic beta-antagonist.
"	A
148195	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CN(CCC1CC(=O)N2CCC(CC2)[C@@H]3C4=C(CCC5=C3N=CC(=C5)Br)C=C(C=C4Br)Cl)C(=O)N
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a Cytochrome P450 3A Inhibitor, Receptor Tyrosine Kinase Inhibitor, Cytochrome P450 2B6 Inhibitor, P-Glycoprotein Inhibitor, Organic Cation Transporter 1 Inhibitor, and Organic Cation Transporter 2 Inhibitor.
Option B: It serves as a Farnesyltransferase Inhibitor, Cytochrome P450 2C8 Inhibitor, Cytochrome P450 3A Inhibitor, P-Glycoprotein Inhibitor, Cytochrome P450 2C19 Inhibitor, Organic Anion Transporting Polypeptide 1B1 Inhibitor, Organic Anion Transporting Polypeptide 1B3 Inhibitor, and Breast Cancer Resistance Protein Inhibitor.
Option C: It acts as a Protein Kinase Inhibitor, Cytochrome P450 3A4 Inducer, Cytochrome P450 2B6 Inducer, Cytochrome P450 2C8 Inducer, Cytochrome P450 2C9 Inducer, Cytochrome P450 2C19 Inducer, Organic Anion Transporting Polypeptide 1B1 Inhibitor, Organic Anion Transporting Polypeptide 1B3 Inhibitor, Organic Anion Transporter 1 Inhibitor, Organic Anion Transporter 3 Inhibitor, and Breast Cancer Resistance Protein Inhibitor.
Option D: It acts as a Kinase Inhibitor, Cytochrome P450 3A Inducer, P-Glycoprotein Inducer, Cytochrome P450 2B6 Inducer, Organic Cation Transporter 1 Inhibitor, Organic Anion Transporter 3 Inhibitor, Multidrug and Toxin Extrusion Transporter 1 Inhibitor, and Breast Cancer Resistance Protein Inhibitor.
"	B
5865	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@]12CC(=O)[C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C
Question about this molecule: What is the mechanism of this molecule?
Option A: It functions as a Corticosteroid Hormone Receptor Agonist.
Option B: It works as a Corticosteroid Hormone Receptor Agonist.
Option C: It is a Gonadotropin Releasing Hormone Receptor Agonist.
Option D: It acts as a Progestational Hormone Receptor Antagonist.
"	A
16220172	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a Protein Kinase Inhibitor, Cytochrome P450 3A4 Inhibitor, Cytochrome P450 2D6 Inhibitor, and mTOR Inhibitor.
Option B: It is a Protein Kinase Inhibitor, Cytochrome P450 3A4 Inhibitor, Cytochrome P450 2D6 Inhibitor, and Cytochrome P450 2C8 Inhibitor.
Option C: It acts as a Chloride Channel Activation Potentiator, Cytochrome P450 2C9 Inhibitor, P-Glycoprotein Inhibitor, and Cytochrome P450 3A Inhibitor.
Option D: It acts as a Tyrosine Kinase Inhibitor, Cytochrome P450 3A Inhibitor, and Cytochrome P450 2C9 Inhibitor.
"	C
9875401	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1COCC(=O)N1C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CC=C(S4)Cl
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a Protein Kinase Inhibitor.
Option B: It inhibits Factor Xa.
Option C: It works as a Protein Kinase Inhibitor.
Option D: It acts as a Factor Xa Inhibitor.
"	B
9865528	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)[C@H](CNCCC2=CC=C(C=C2)NC(=O)CC3=CSC(=N3)N)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It is an adrenergic beta3-agonist, and inhibits Cytochrome P450 2D6, Cytochrome P450 3A, and P-Glycoprotein.
Option B: It inhibits Kinase, Cytochrome P450 3A, Cytochrome P450 3A4, Cytochrome P450 1A2, and Breast Cancer Resistance Protein.
Option C: It inhibits Cytochrome P450 3A4, Cytochrome P450 2C19, and Cytochrome P450 2C9.
Option D: It inhibits Cytochrome P450 17A1, Cytochrome P450 2D6, and Cytochrome P450 2C8.
"	A
3086674	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC(=O)[C@@H]1[C@H]2CC[C@H](N2CCCF)C[C@@H]1C3=CC=C(C=C3)[123I]
Question about this molecule: What is the mechanism of this molecule?
Option A: It has a radiopharmaceutical activity mechanism of action.
Option B: It is a Radiopharmaceutical Activity.
Option C: It exhibits Magnetic Resonance Contrast Activity.
Option D: It exhibits Radiopharmaceutical Activity.
"	D
67683363	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1CC[C@H](N1C(=O)[C@H](C(C)C)NC(=O)OC)C2=NC3=C(N2)C=CC4=CC5=C(C=C43)OCC6=C5C=CC(=C6)C7=CN=C(N7)[C@@H]8C[C@@H](CN8C(=O)[C@@H](C9=CC=CC=C9)NC(=O)OC)COC
Question about this molecule: What is the mechanism of this molecule?
Option A: It serves as an HCV NS3/4A protease inhibitor, cytochrome P450 3A inhibitor, P-glycoprotein inhibitor, organic anion transporting polypeptide 1B1 inhibitor, and organic anion transporting polypeptide 2B1 inhibitor.
Option B: It acts as a histone deacetylase inhibitor, bile salt export pump inhibitor, organic anion transporting polypeptide 1B1 inhibitor, organic anion transporting polypeptide 1B3 inhibitor, organic anion transporter 1 inhibitor, and organic cation transporter 2 inhibitor.
Option C: It inhibits P-glycoprotein, organic anion transporting polypeptide 1B1, organic anion transporting polypeptide 1B3, and breast cancer resistance protein.
Option D: It inhibits Breast Cancer Resistance Protein, P-Glycoprotein, Organic Anion Transporting Polypeptide 1B1, Organic Anion Transporting Polypeptide 1B3, and Organic Anion Transporting Polypeptide 2B1.
"	D
2145	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC1(CCC(=O)NC1=O)C2=CC=C(C=C2)N
Question about this molecule: What is the mechanism of this molecule?
Option A: It acts as an Adrenal Steroid Synthesis Inhibitor.
Option B: It functions as a Nucleic Acid Synthesis Inhibitor.
Option C: It acts as a Nucleic Acid Synthesis Inhibitor.
Option D: It works as an Adrenal Steroid Synthesis Inhibitor.
"	D
64143	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(C=CC=C1O)C(=O)N[C@@H](CSC2=CC=CC=C2)[C@@H](CN3C[C@H]4CCCC[C@H]4C[C@H]3C(=O)NC(C)(C)C)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It works as a HIV Protease Inhibitor, Cytochrome P450 3A Inhibitor, and Cytochrome P450 2D6 Inhibitor.
Option B: It acts as a Tyrosine Kinase Inhibitor, Cytochrome P450 3A Inhibitor, and Cytochrome P450 2C9 Inhibitor.
Option C: It is a Protein Kinase Inhibitor, Cytochrome P450 3A4 Inhibitor, Cytochrome P450 2D6 Inhibitor, and Cytochrome P450 2C8 Inhibitor.
Option D: It works as a HIV Protease Inhibitor and Cytochrome P450 3A Inhibitor.
"	D
16136912	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1[C@@H]([C@@](C[C@@H](O1)O[C@H]2[C@H]3C(=O)N[C@@H](C4=C(C(=CC(=C4)O)O)C5=C(C=CC(=C5)[C@H](C(=O)N3)NC(=O)[C@H]6C7=CC(=C(C(=C7)OC8=C(C=C2C=C8)Cl)O[C@H]9[C@@H]([C@H]([C@@H]([C@H](O9)CO)O)O)O[C@H]1C[C@]([C@H]([C@@H](O1)C)O)(C)NCC1=CC=C(C=C1)C1=CC=C(C=C1)Cl)OC1=C(C=C(C=C1)[C@H]([C@H](C(=O)N[C@H](C(=O)N6)CC(=O)N)NC(=O)[C@@H](CC(C)C)NC)O)Cl)O)C(=O)O)(C)N)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a Cytochrome P450 3A Inhibitor, P-Glycoprotein Inhibitor, Cytochrome P450 1A2 Inhibitor, Cytochrome P450 2C9 Inhibitor, and Cytochrome P450 2D6 Inhibitor.
Option B: It acts as a Cytochrome P450 1A2 Inducer, Cytochrome P450 2B6 Inducer, Cytochrome P450 2C8 Inducer, Cytochrome P450 2C19 Inducer, Cytochrome P450 2D6 Inducer, Cytochrome P450 3A Inducer, and Cytochrome P450 2C9 Inducer.
Option C: It works as a Cytochrome P450 2C19 Inhibitor, Cytochrome P450 2C9 Inhibitor, Cytochrome P450 3A4 Inducer, and Cytochrome P450 2D6 Inducer.
Option D: It serves as a Cytochrome P450 3A4 Inducer, Cytochrome P450 1A2 Inducer, Cytochrome P450 2B6 Inducer, Cytochrome P450 2C9 Inducer, and Cytochrome P450 2C19 Inducer.
"	C
16678941	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It inhibits ergosterol synthesis, leading to increased cellular permeability.
Option B: It inhibits ergosterol synthesis, resulting in increased cellular permeability and leakage of cellular contents.
Option C: It aids the conformational stability of F508del-mutated CFTR proteins, preventing misfolding and resulting in increased processing and trafficking of mature protein to the cell surface.
Option D: It acts as a non-competitive inhibitor for an enzyme in mitochondria called cytochrome c oxidase, halting cellular respiration.
"	C
9853053	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C(=O)NCC(F)(F)F
Question about this molecule: What is the mechanism of this molecule?
Option A: It inhibits Microsomal Triglyceride Transfer Protein, Cytochrome P450 3A4, and P-Glycoprotein.
Option B: It inhibits Glucosylceramide Synthase, P-Glycoprotein, and Cytochrome P450 2D6.
Option C: It is a P2Y12 Receptor Antagonist, Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor.
Option D: It is an adrenergic beta3-agonist, and inhibits Cytochrome P450 2D6, Cytochrome P450 3A, and P-Glycoprotein.
"	A
6323266	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CC(=N)N(C1)CC2=C(C(=O)NC(=O)N2)Cl
Question about this molecule: What is the mechanism of this molecule?
Option A: It inhibits P-glycoprotein.
Option B: It inhibits Thymidine Phosphorylase.
Option C: It inhibits melanin synthesis.
Option D: It inhibits protein synthesis.
"	B
11658860	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1CNCCC2=C1C=C(C=C2)Cl
Question about this molecule: What is the mechanism of this molecule?
Option A: It acts as a Vasopressin Receptor Antagonist and Cytochrome P450 3A Inhibitor.
Option B: It is a P2Y12 Receptor Antagonist, Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor.
Option C: It is a Serotonin Uptake Inhibitor and Cytochrome P450 2D6 Inhibitor.
Option D: It acts as a Serotonin 2c Receptor Agonist and Cytochrome P450 2D6 Inhibitor.
"	D
123606	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN(C)CCC1=CNC2=C1C=C(C=C2)CS(=O)(=O)N3CCCC3
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a serotonin 1b receptor agonist and serotonin 1d receptor agonist.
Option B: It acts as a Serotonin 4 Receptor Agonist.
Option C: It acts as a Serotonin Uptake Inhibitor.
Option D: It functions as a Serotonin 1b Receptor Agonist and Serotonin 1d Receptor Agonist.
"	A
23725625	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a Poly(ADP-Ribose) Polymerase Inhibitor.
Option B: It acts as a DNA Polymerase Inhibitor.
Option C: It functions as a DNA Polymerase Inhibitor.
Option D: It is a Topoisomerase Inhibitor.
"	A
387447	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: B([C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It works as a Proteasome Inhibitor.
Option B: It acts as a Proton Pump Inhibitor.
Option C: It functions as a Proton Pump Inhibitor.
Option D: It acts as a Proteasome Inhibitor.
"	D
60648	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(SC=C1)C(=CCCN2CCC[C@H](C2)C(=O)O)C3=C(C=CS3)C
Question about this molecule: What is the mechanism of this molecule?
Option A: It works as a serotonin uptake inhibitor.
Option B: It is a serotonin 3 receptor antagonist.
Option C: It operates as a selective GABA reuptake inhibitor.
Option D: It acts as a Serotonin Uptake Inhibitor.
"	C
5361092	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CC[C@]2([C@H]3CC4=C([C@]2(C1)CCN3CC5CCC5)C=C(C=C4)O)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It acts as an Opioid mu-Receptor Agonist.
Option B: It is a Full Opioid Agonist.
Option C: It acts as a Competitive Opioid Antagonist and Partial Opioid Agonist.
Option D: It acts as a Partial Opioid Agonist.
"	C
5035	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It has a gonadotropin releasing hormone receptor antagonist mechanism of action.
Option B: It acts as a selective estrogen receptor modulator.
Option C: It acts as a GABA A receptor positive modulator.
Option D: It functions as an estrogen receptor antagonist and selective estrogen receptor modulator.
"	B
3168	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CN(CC=C1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F
Question about this molecule: What is the mechanism of this molecule?
Option A: It acts as a dopamine agonist.
Option B: It functions as a Dopamine Agonist.
Option C: It acts as a dopamine D2 antagonist.
Option D: It serves as a dopamine agonist.
"	C
174174	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)C(CO)C3=CC=CC=C3
Question about this molecule: What is the mechanism of this molecule?
Option A: It works as a Cholinergic Agonist.
Option B: It is a Cholinergic Antagonist and Cholinergic Muscarinic Antagonist.
Option C: It is a Cholinergic Muscarinic Antagonist.
Option D: It works as a Cholinergic Muscarinic Agonist.
"	B
4158	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC(=O)C(C1CCCCN1)C2=CC=CC=C2
Question about this molecule: What is the mechanism of this molecule?
Option A: It acts on brain catecholaminergic neurons and inhibits dopamine uptake.
Option B: Its exact mechanism of action is unclear, but it inhibits the reuptake of dopamine by binding to the dopamine reuptake pump, leading to an increase in extracellular dopamine.
Option C: It blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins.
Option D: The precise mechanism of action is unknown, but it is postulated to block postsynaptic dopamine receptors.
"	C
51263	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCN3C(=O)N(N=N3)CC)COC
Question about this molecule: What is the mechanism of this molecule?
Option A: It acts as an Opioid mu-Receptor Agonist.
Option B: It is a Full Opioid Agonist.
Option C: It acts as a Competitive Opioid Antagonist and Partial Opioid Agonist.
Option D: It acts as a Partial Opioid Agonist.
"	B
135400189	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCC1=NC(=C2N1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CC)OCC)C
Question about this molecule: What is the mechanism of this molecule?
Option A: It inhibits Phosphodiesterase 5.
Option B: It acts as a Phosphodiesterase 4 Inhibitor.
Option C: It is a Phosphodiesterase 5 Inhibitor.
Option D: It inhibits Phosphodiesterase 3.
"	C
5775	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC=C(C=C1)N(CC2=NCCN2)C3=CC(=CC=C3)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It acts as an Adrenergic alpha1-Agonist.
Option B: It functions as an Adrenergic beta-Antagonist.
Option C: It works as an Adrenergic alpha2-Agonist.
Option D: It acts as an Adrenergic alpha-Antagonist.
"	D
4058	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCOC(=O)C1(CCN(CC1)C)C2=CC=CC=C2
Question about this molecule: What is the mechanism of this molecule?
Option A: It acts as a Competitive Opioid Antagonist and Partial Opioid Agonist.
Option B: It acts as an Opioid mu-Receptor Agonist.
Option C: It is a Full Opioid Agonist.
Option D: It acts as a Partial Opioid Agonist.
"	C
1986	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(=O)NC1=NN=C(S1)S(=O)(=O)N
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a Carbonic Anhydrase Inhibitor.
Option B: It acts as a Dipeptidase Inhibitor.
Option C: It acts as a Carbonic Anhydrase Inhibitor and P-Glycoprotein Inhibitor.
Option D: It serves as a Carbonic Anhydrase Inhibitor.
"	A
5360696	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CC[C@@]23CCCC[C@@H]2[C@@H]1CC4=C3C=C(C=C4)OC
Question about this molecule: What is the mechanism of this molecule?
Option A: It acts as an Opioid mu-Receptor Agonist.
Option B: It functions as a Serotonin 1b Receptor Agonist and Serotonin 1d Receptor Agonist.
Option C: It is an Uncompetitive NMDA Receptor Antagonist and Sigma-1 Receptor Agonist.
Option D: It acts as a Competitive Opioid Antagonist and Partial Opioid Agonist.
"	C
15950376	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CNC1=C(C=C(C=C1)C2=NC3=C(S2)C=C(C=C3)O)[18F]
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a Radiopharmaceutical Activity.
Option B: It exhibits Radiopharmaceutical Activity.
Option C: It exhibits Magnetic Resonance Contrast Activity.
Option D: It has a radiopharmaceutical activity mechanism of action.
"	D
54676228	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=CC=CC=N3
Question about this molecule: What is the mechanism of this molecule?
Option A: It inhibits cyclooxygenase.
Option B: It has a 5-lipoxygenase inhibitor mechanism of action.
Option C: It has a cyclooxygenase inhibitor mechanism of action.
Option D: It serves as a cyclooxygenase inhibitor.
"	C
3476	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC1=C(CN(C1=O)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)C)C
Question about this molecule: What is the mechanism of this molecule?
Option A: It inhibits urate crystal deposition, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes.
Option B: It alters signal conduction in neurons by blocking fast voltage-gated sodium (Na+) channels in the neuronal cell membrane responsible for signal propagation.
Option C: It stimulates the secretion of insulin granules from pancreatic islet beta cells by blocking ATP-sensitive potassium channels (KATP channels) and causing depolarization of the beta cells.
Option D: It stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.
"	C
5362129	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2[C@H]3CCC[C@H]3C[C@H]2C(=O)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It functions as an angiotensin 2 receptor antagonist.
Option B: It acts as an angiotensin 2 receptor antagonist.
Option C: It has an angiotensin-converting enzyme inhibitor mechanism of action.
Option D: It is an angiotensin 2 type 1 receptor antagonist.
"	C
5310966	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1[C@@H]2CNC[C@H]1C3=CC4=NC=CN=C4C=C23
Question about this molecule: What is the mechanism of this molecule?
Option A: It acts as a cholinergic agonist.
Option B: It has a partial cholinergic nicotinic agonist and cholinergic agonist mechanism of action.
Option C: It functions as a cholinergic muscarinic antagonist.
Option D: It acts as a cholinergic agonist and cholinergic muscarinic agonist.
"	B
193962	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=CC(=C1OC2=NC(=NC(=C2Br)N)NC3=CC=C(C=C3)C#N)C)C#N
Question about this molecule: What is the mechanism of this molecule?
Option A: It inhibits Bcr-Abl tyrosine kinase, cytochrome P450 2C8, cytochrome P450 2D6, and UGT1A1, and it induces cytochrome P450 2B6 and cytochrome P450 2C8, and it inhibits P-glycoprotein.
Option B: It acts as a non-nucleoside reverse transcriptase inhibitor, cytochrome P450 3A inducer, cytochrome P450 2B6 inducer, cytochrome P450 2C9 inhibitor, cytochrome P450 2C19 inhibitor, and cytochrome P450 3A4 inhibitor.
Option C: It is an androgen receptor antagonist, cytochrome P450 3A4 inducer, cytochrome P450 2C9 inducer, and cytochrome P450 2C19 inducer.
Option D: It has a non-nucleoside reverse transcriptase inhibitor, cytochrome P450 3A inducer, cytochrome P450 2C9 inhibitor, cytochrome P450 2C19 inhibitor, and P-glycoprotein inhibitor mechanism of action.
"	D
11250029	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=CC(=C1C[C@@H](C(=O)N(CC2=CC(=C(C=C2)OC)C(=O)O)[C@@H](C)C3=NC=C(N3)C4=CC=CC=C4)N)C)C(=O)N
Question about this molecule: What is the mechanism of this molecule?
Option A: It acts as an Opioid mu-Receptor Agonist.
Option B: It acts as a Competitive Opioid Antagonist and Partial Opioid Agonist.
Option C: It acts as a Partial Opioid Agonist.
Option D: It is a Full Opioid Agonist.
"	A
110635	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CC(=O)N2[C@@H](C1=O)CC3=C([C@H]2C4=CC5=C(C=C4)OCO5)NC6=CC=CC=C36
Question about this molecule: What is the mechanism of this molecule?
Option A: It inhibits Phosphodiesterase 5.
Option B: It is a Phosphodiesterase 5 Inhibitor.
Option C: It inhibits Phosphodiesterase 3.
Option D: It acts as a Phosphodiesterase 4 Inhibitor.
"	A
216326	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N
Question about this molecule: What is the mechanism of this molecule?
Option A: It promotes malignant cell death and enhances host immunity.
Option B: It mimics epilepsy by blocking the inhibitory action of GABA receptors.
Option C: It modulates neurotransmission to treat pharmacoresistant seizures.
Option D: It alters signal conduction in neurons by blocking fast voltage-gated sodium (Na+) channels in the neuronal cell membrane responsible for signal propagation.
"	A
6450551	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=CC=N4
Question about this molecule: What is the mechanism of this molecule?
Option A: It serves as a Serotonin Uptake Inhibitor.
Option B: It acts as a Bcr-Abl Tyrosine Kinase Inhibitor.
Option C: It acts as a Serotonin Uptake Inhibitor.
Option D: It inhibits Receptor Tyrosine Kinase.
"	D
135449332	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(C=C(C=C1)N2C(=O)C(=C(N2)C)N=NC3=CC=CC(=C3O)C4=CC(=CC=C4)C(=O)O)C
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a Kinase Inhibitor, Cytochrome P450 2C9 Inhibitor, Breast Cancer Resistance Protein Inhibitor, UGT1A9 Inhibitor, and UGT1A1 Inhibitor.
Option B: It acts as a Thrombopoietin Receptor Agonist, Organic Anion Transporting Polypeptide 1B1 Inhibitor, Breast Cancer Resistance Protein Inhibitor, UGT1A1 Inhibitor, UGT1A3 Inhibitor, UGT1A4 Inhibitor, UGT1A6 Inhibitor, UGT1A9 Inhibitor, UGT2B7 Inhibitor, and UGT2B15 Inhibitor.
Option C: It serves as a Farnesyltransferase Inhibitor, Cytochrome P450 2C8 Inhibitor, Cytochrome P450 3A Inhibitor, P-Glycoprotein Inhibitor, Cytochrome P450 2C19 Inhibitor, Organic Anion Transporting Polypeptide 1B1 Inhibitor, Organic Anion Transporting Polypeptide 1B3 Inhibitor, and Breast Cancer Resistance Protein Inhibitor.
Option D: It serves as an AMPA Receptor Antagonist, UGT2B7 Inhibitor, UGT1A9 Inhibitor, Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C8 Inhibitor.
"	B
57379345	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=C(C=C1C2CCNCC2)OC(C)C)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)C(C)C)Cl
Question about this molecule: What is the mechanism of this molecule?
Option A: It acts as a Tyrosine Kinase Inhibitor, Cytochrome P450 3A Inhibitor, and Cytochrome P450 2C9 Inhibitor.
Option B: It acts as a Cytochrome P450 2C19 Inhibitor, Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C9 Inhibitor.
Option C: It is a Protein Kinase Inhibitor, Cytochrome P450 3A4 Inhibitor, Cytochrome P450 2D6 Inhibitor, and Cytochrome P450 2C8 Inhibitor.
Option D: It is a Protein Kinase Inhibitor, Cytochrome P450 3A4 Inhibitor, Cytochrome P450 2D6 Inhibitor, and mTOR Inhibitor.
"	A
5734	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C2C(=C1)C(=NO2)CS(=O)(=O)N
Question about this molecule: What is the mechanism of this molecule?
Option A: It is a Carbonic Anhydrase Inhibitor.
Option B: It acts as a Carbonic Anhydrase Inhibitor and P-Glycoprotein Inhibitor.
Option C: It acts as a Dipeptidase Inhibitor.
Option D: It serves as a Carbonic Anhydrase Inhibitor.
"	B
135423438	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N=C(C3=CC=CC=C3)C4=C(NC5=C4C=CC(=C5)C(=O)OC)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It works as a Proteasome Inhibitor.
Option B: It acts as a Lipase Inhibitor.
Option C: It works as a Protein Kinase Inhibitor.
Option D: It is a Protein Kinase Inhibitor.
"	D
33887	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C=CCNC1=NC(=NC(=N1)N2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)NCC=C
Question about this molecule: What is the mechanism of this molecule?
Option A: It acts as an Opioid mu-Receptor Agonist.
Option B: It acts as an agonist of peripheral chemoreceptors located on the carotid bodies.
Option C: It acts as a Competitive Opioid Antagonist and Partial Opioid Agonist.
Option D: It acts as a Partial Opioid Agonist.
"	B
4463	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C2C(=NC=C1)N(C3=C(C=CC=N3)C(=O)N2)C4CC4
Question about this molecule: What is the mechanism of this molecule?
Option A: It acts as a nucleoside reverse transcriptase inhibitor.
Option B: It inhibits nucleoside reverse transcriptase.
Option C: It acts as a non-nucleoside reverse transcriptase inhibitor.
Option D: It is a nucleoside reverse transcriptase inhibitor and cytochrome P450 1A1 inhibitor.
"	C
10077130	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCOC(=O)N[C@@H]1CC[C@@H]2[C@@H](C1)C[C@@H]3[C@H]([C@H]2/C=C/C4=NC=C(C=C4)C5=CC(=CC=C5)F)[C@H](OC3=O)C
Question about this molecule: What is the mechanism of this molecule?
Option A: It antagonizes Protease-activated Receptor-1.
Option B: It antagonizes androgen receptors.
Option C: It antagonizes smoothened receptors.
Option D: It antagonizes adenosine A3 receptors.
"	A
123683	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CNC(=O)[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)NCC4=CC(=CC=C4)I)O)O
Question about this molecule: What is the mechanism of this molecule?
Option A: It antagonizes smoothened receptors.
Option B: It antagonizes androgen receptors.
Option C: It antagonizes Protease-activated Receptor-1.
Option D: It antagonizes adenosine A3 receptors.
"	D
156419	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H](C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F
Question about this molecule: What is the mechanism of this molecule?
Option A: It exerts its effects by binding to the α2δ subunit of voltage-dependent calcium channels.
Option B: It inhibits repeated neuronal firing and stabilizes the inactivated state of voltage-gated sodium channels.
Option C: It can decrease intracellular calcium levels by inhibiting calcium influx through voltage-gated calcium channels.
Option D: It increases calcium-sensing receptor sensitivity.
"	D
4493	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(C(=O)N(C(=O)N1)C2=CC(=C(C=C2)[N+](=O)[O-])C(F)(F)F)C
Question about this molecule: What is the mechanism of this molecule?
Option A: It antagonizes androgen receptors.
Option B: It antagonizes Adrenergic alpha receptors.
Option C: It antagonizes smoothened receptors.
Option D: It antagonizes Protease-activated Receptor-1.
"	A
4763	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC1(C(=O)NC(=O)NC1=O)C2=CC=CC=C2
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: It is a commonly used oral antihypertensive agent that acts by inducing peripheral vasodilation.
Option B: It acts as a nonselective central nervous system depressant.
Option C: It is a centrally acting sympatholytic agent and an antihypertensive agent.
Option D: It selectively targets mutant proteins in malignant cells, acting similarly to erlotinib.
"	B
5284627	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(O[C@@H]2CO[C@@]3([C@H]([C@@H]2O1)OC(O3)(C)C)COS(=O)(=O)N)C
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.
Option B: It is an inhibitor of carbonic anhydrase, particularly subtypes II and IV.
Option C: It has a broad spectrum of action, being systemic with protective and curative action.
Option D: It is a common active ingredient in toothpaste, exerting an anti-sensitivity action.
"	B
6918485	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@H](C1=NC(=CS1)C2=CC=C(C=C2)C#N)[C@](CN3C=NC=N3)(C4=C(C=CC(=C4)F)F)O
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: It inhibits the mucopeptide synthesis in the bacterial cell wall.
Option B: It inhibits the activity of the squalene epoxidase enzyme that is essential in the formation of sterols necessary for fungal cell membranes.
Option C: It inhibits fungal cell membrane synthesis.
Option D: It interferes with the synthesis of vital cell wall components, which leads to cell death.
"	C
37542	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=NC(=NN1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(=O)N
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: It induces a conformational change in the estrogen receptors (ER).
Option B: It inhibits DNA synthesis and interacts with SH groups.
Option C: It blocks RNA synthesis and ribosome function, and is used mainly as a tool in biochemistry.
Option D: It blocks viral RNA synthesis and viral mRNA capping.
"	D
2159	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCN1CCCC1CNC(=O)C2=CC(=C(C=C2OC)N)S(=O)(=O)CC
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: It has a relatively lower risk of extrapyramidal adverse effects compared to other atypical antipsychotic agents.
Option B: It aims to target the underlying disease by blocking the effects of the primary androgen involved in benign prostate hyperplasia and androgenic alopecia, thus reducing the risk for secondary complications while providing symptom control.
Option C: It is a diuretic drug with uric acid-lowering action which was marketed for the treatment of hypertension.
Option D: It is a common active ingredient in toothpaste, exerting an anti-sensitivity action.
"	A
3152	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: It inhibits acetylcholinesterase in the nervous system of insects.
Option B: It acts as an acetylcholinesterase inhibitor to control insects in a wide range of crops.
Option C: It is non-systemic with contact and stomach action, and an acetylcholinesterase (AChE) inhibitor.
Option D: It is a centrally acting reversible acetyl cholinesterase inhibitor.
"	D
9887712	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)Cl
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: It inhibits beta-tubulin synthesis, inhibiting development of germ tubes and the growth of mycelia.
Option B: It inhibits spinal polysynaptic afferent pathways and, to a lesser extent, monosynaptic afferent pathways.
Option C: It induces bronchoconstriction through muscarinic receptors in the lungs.
Option D: It inhibits glucose reabsorption in the proximal tubule of the nephron and causes glycosuria.
"	D
30479	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)(C)C1=NN=C(N(C1=O)N)SC
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: It inhibits fungal cell membrane synthesis.
Option B: It inhibits photosynthesis and the Hill reaction in plants.
Option C: It inhibits photosynthesis by disrupting photosystem II.
Option D: It activates glutamatergic circuits while inhibiting GABA.
"	C
15938	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[N+]1=CC=C(C=C1)C2=CC=[N+](C=C2)C.[Cl-].[Cl-]
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: It disrupts microtubules, blocking anisotropic growth of plant cells.
Option B: It is used in cereal seed dressing and fungicidal non-mercurial seed dressing with special action against fusarium.
Option C: It selectively targets mutant proteins in malignant cells, acting similarly to erlotinib.
Option D: It kills green plant tissue on contact.
"	D
2092	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN(CCCNC(=O)C1CCCO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: It mainly acts on the cells of the distal part of the nephron and the collecting tubules in the kidney.
Option B: It relaxes the smooth muscle of the bladder in the treatment of urinary frequency and incontinence.
Option C: It relaxes the muscles in the prostate and bladder neck, used in the symptomatic treatment of BPH.
Option D: It blocks the action of androgens of adrenal and testicular origin that stimulate the growth of normal and malignant prostatic tissue.
"	C
123631	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: It selectively targets mutant proteins in malignant cells, acting similarly to erlotinib.
Option B: It inhibits beta-tubulin synthesis, inhibiting development of germ tubes and the growth of mycelia.
Option C: It induces bronchoconstriction through muscarinic receptors in the lungs.
Option D: This occurrence led to the development of novel second-generation ALK inhibitors such as this molecule to overcome crizotinib resistance.
"	A
149096	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: It disrupts the function of new HCV replication complexes by modulating the NS5A phosphorylation status.
Option B: It inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Option C: It exerts its action by binding on the benzodiazepine receptor complex and modulation of the GABABZ receptor chloride channel macromolecular complex.
Option D: Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.
"	B
2749	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=O)N(C(=C1)C2CCCCC2)O
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.
Option B: It acts through the chelation of polyvalent metal cations, such as Fe3+ and Al3+.
Option C: It binds to surface membranes and proteins, causing proton leaks and cell death.
Option D: It acts via decreasing aqueous humor synthesis.
"	B
62887	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[N@@+]1(CCC2=CC(=C(C=C2[C@H]1CC3=CC(=C(C=C3)OC)OC)OC)OC)CCC(=O)OCCCCCOC(=O)CC[N@+]4(CCC5=CC(=C(C=C5[C@H]4CC6=CC(=C(C=C6)OC)OC)OC)OC)C
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: It prevents transmission of impulses along nerve fibers and at nerve endings.
Option B: It acts at inhibitory synapses in the brain.
Option C: It blocks neuromuscular transmission.
Option D: It activates glutamatergic circuits while inhibiting GABA.
"	C
9865528	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)[C@H](CNCCC2=CC=C(C=C2)NC(=O)CC3=CSC(=N3)N)O
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: It relaxes the smooth muscle of the bladder in the treatment of urinary frequency and incontinence.
Option B: It mainly acts on the cells of the distal part of the nephron and the collecting tubules in the kidney.
Option C: It relaxes the muscles in the prostate and bladder neck, used in the symptomatic treatment of BPH.
Option D: It blocks the action of androgens of adrenal and testicular origin that stimulate the growth of normal and malignant prostatic tissue.
"	A
9433	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1C2=C(C(=O)N(C1=O)C)NC=N2.CN1C2=C(C(=O)N(C1=O)C)NC=N2.C(CN)N
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: It exerts its action by binding on the benzodiazepine receptor complex and modulation of the GABABZ receptor chloride channel macromolecular complex.
Option B: It blocks the D2 somatodendritic autoreceptor, resulting in the blockade of postsynaptic dopamine receptors in the mesolimbic system and an increased dopamine turnover.
Option C: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors.
Option D: It acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator.
"	D
123606	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN(C)CCC1=CNC2=C1C=C(C=C2)CS(=O)(=O)N3CCCC3
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: It narrows blood vessels in the brain, stops pain signals from being sent to the brain, and stops the release of certain natural substances that cause pain, nausea, and other symptoms of migraine.
Option B: It aims to target the underlying disease by blocking the effects of the primary androgen involved in benign prostate hyperplasia and androgenic alopecia, thus reducing the risk for secondary complications while providing symptom control.
Option C: It blocks the effects of glutamate, a neurotransmitter in the brain that leads to neuronal excitability and excessive stimulation in Alzheimer's Disease.
Option D: Dopamine-antagonizing medications such as this molecule are though to improve psychotic symptoms and states that are caused by an over-production of dopamine, such as schizophrenia, which is theorized to be caused by a hyperdopaminergic state within the limbic system of the brain.
"	A
2913	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CCC(=C2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: It blocks the action of endogenous histamine, leading to temporary relief of the negative symptoms brought on by histamine.
Option B: It can reduce symptoms through its actions on histamine receptors.
Option C: It competes with free histamine for binding at HA-receptor sites.
Option D: It blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins.
"	C
4747	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CN(CCC1O)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C#N
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: It acts indirectly on reticular formation, whereby neuronal activity into reticular formation is reduced without affecting its intrinsic ability to activate the cerebral cortex.
Option B: It acts principally in the subcortical areas, by producing what has been described as a central adrenergic blockade.
Option C: It exerts a non-genomic action by targeting important signaling molecules in vascular endothelial cells (ECs).
Option D: This molecule acts by causing the arrest of cells in metaphase mitosis through its inhibition tubulin mitotic functioning.
"	B
4158	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC(=O)C(C1CCCCN1)C2=CC=CC=C2
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: It blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins.
Option B: It selectively targets mutant proteins in malignant cells, acting similarly to erlotinib.
Option C: It activates glutamatergic circuits while inhibiting GABA.
Option D: It inhibits functioning of postsynaptic dopamine receptors.
"	A
3476	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC1=C(CN(C1=O)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)C)C
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization.
Option B: It induces bronchoconstriction through muscarinic receptors in the lungs.
Option C: It stimulates the secretion of insulin granules from pancreatic islet beta cells by blocking ATP-sensitive potassium channels (KATP channels) and causing depolarization of the beta cells.
Option D: It binds to angiotensin II type 1 (AT1) receptors, inhibiting the action of angiotensin II on vascular smooth muscle and reducing arterial blood pressure.
"	C
193962	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=CC(=C1OC2=NC(=NC(=C2Br)N)NC3=CC=C(C=C3)C#N)C)C#N
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: It selectively targets mutant proteins in malignant cells, acting similarly to erlotinib.
Option B: It is used in cereal seed dressing and fungicidal non-mercurial seed dressing with special action against fusarium.
Option C: It is a commonly used oral antihypertensive agent that acts by inducing peripheral vasodilation.
Option D: Patients are advised to immediately contact their healthcare provider if a rash develops.
"	D
57379345	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=C(C=C1C2CCNCC2)OC(C)C)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)C(C)C)Cl
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: It induces bronchoconstriction through muscarinic receptors in the lungs.
Option B: This molecule acts by causing the arrest of cells in metaphase mitosis through its inhibition tubulin mitotic functioning.
Option C: Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization.
Option D: This occurrence led to the development of novel second-generation ALK inhibitors such as this molecule to overcome crizotinib resistance.
"	D
5734	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C2C(=C1)C(=NO2)CS(=O)(=O)N
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: It binds to angiotensin II type 1 (AT1) receptors, inhibiting the action of angiotensin II on vascular smooth muscle and reducing arterial blood pressure.
Option B: Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization.
Option C: It may act by blocking repetitive firing of voltage-gated sodium channels leading to a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors.
Option D: It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation.
"	C
19756	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C2C(=C1)NC(=N2)C3=CC=CO3
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: This occurrence led to the development of novel second-generation ALK inhibitors such as this molecule to overcome crizotinib resistance.
Option B: It inhibits beta-tubulin synthesis, inhibiting development of germ tubes and the growth of mycelia.
Option C: It acts indirectly on reticular formation, whereby neuronal activity into reticular formation is reduced without affecting its intrinsic ability to activate the cerebral cortex.
Option D: It is used in cereal seed dressing and fungicidal non-mercurial seed dressing with special action against fusarium.
"	D
5479530	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1C(=NC(=O)C(=O)N1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\\OC)/C4=CSC(=N4)N)SC2)C(=O)O
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: It inhibits the mucopeptide synthesis in the bacterial cell wall.
Option B: It inhibits the activity of the squalene epoxidase enzyme that is essential in the formation of sterols necessary for fungal cell membranes.
Option C: It interferes with the synthesis of vital cell wall components, which leads to cell death.
Option D: It inhibits fungal cell membrane synthesis.
"	A
4493	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(C(=O)N(C(=O)N1)C2=CC(=C(C=C2)[N+](=O)[O-])C(F)(F)F)C
Question about this molecule: What is the right information about this molecule's medical effects?
Option A: It relaxes the smooth muscle of the bladder in the treatment of urinary frequency and incontinence.
Option B: It mainly acts on the cells of the distal part of the nephron and the collecting tubules in the kidney.
Option C: It blocks the action of androgens of adrenal and testicular origin that stimulate the growth of normal and malignant prostatic tissue.
Option D: It relaxes the muscles in the prostate and bladder neck, used in the symptomatic treatment of BPH.
"	C
36324	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=C(C=C1)N=CN(C)C=NC2=C(C=C(C=C2)C)C)C
Question about this molecule: What is the right information about this molecule's melting point?
Option A: Melting point 104-106 °F (40-41 °C)
Option B: Melting point 265 °F (129-130 °C)
Option C: Melting point 123-131 °C (253-268 °F)
Option D: Melting point 187-189 °F (86-87 °C)
"	D
5284627	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(O[C@@H]2CO[C@@]3([C@H]([C@@H]2O1)OC(O3)(C)C)COS(=O)(=O)N)C
Question about this molecule: What is the right information about this molecule's metabolism?
Option A: It is mainly metabolized by CYP3As.
Option B: It is oxidized to aromatic compounds including ortho-cresol, which is not found significantly in the urine of nonexposed individuals.
Option C: It is metabolized through conjugation, mainly sulphation and glucuronization.
Option D: It is extensively metabolized by hydroxylation, hydrolysis, and glucuronidation.
"	D
37542	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=NC(=NN1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(=O)N
Question about this molecule: What is the right information about this molecule's metabolism?
Option A: It is mainly metabolized by CYP3As.
Option B: It is metabolized by conjugation and oxidation.
Option C: It is metabolized into nucleoside analogs that blocks viral RNA synthesis and viral mRNA capping.
Option D: It is metabolized by the enzyme monoamine oxidase.
"	C
27661	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1[C@@H]([C@@H]2[C@H](O1)[C@@H](CO2)O[N+](=O)[O-])O
Question about this molecule: What is the right information about this molecule's metabolism?
Option A: This molecule can be metabolized to dopamine on either side of the blood-brain barrier and is generally administered with a dopa decarboxylase inhibitor like carbidopa to prevent metabolism until after it has crossed the blood-brain barrier.
Option B: This molecule is a prodrug that is metabolized to an active form, which blocks the ADP receptor involved in GPIIb/IIIa receptor activation leading to platelet aggregation.
Option C: This molecule has a slow onset of absorption and metabolism, resulting in a longer duration of action than nitroglycerin.
Option D: In HIV-1-infected patients and in patients with Lyme neuroborreliosis, a marked rise of KYNA metabolism was seen.
"	C
5983	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@]12CCN([C@@H]1N(C3=C2C=C(C=C3)OC(=O)NC)C)C
Question about this molecule: What is the odor of this molecule?
Option A: It is usually odorless.
Option B: It is essentially odorless.
Option C: It is odorless.
Option D: It is practically odorless.
"	C
10129	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1CCC2CC1C2(C)C
Question about this molecule: What is the odor of this molecule?
Option A: It has a mild sweet odor.
Option B: It has a mild odor.
Option C: It has a mild pleasant odor.
Option D: It has a mild distinctive odor.
"	B
1775	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)C2(C(=O)NC(=O)N2)C3=CC=CC=C3
Question about this molecule: What is the odor of this molecule?
Option A: It is odorless to a faint onion-like odor.
Option B: It is odorless or nearly odorless.
Option C: It is odorless or almost odorless.
Option D: It has a very faint aromatic or phenolic odor.
"	C
7220	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC2=NNN=C2C=C1
Question about this molecule: What is the odor of this molecule?
Option A: Strong odor.
Option B: No odor.
Option C: Strong irritating odor
Option D: Strong odor of ammonia
"	B
17038	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C=CCC2C1C(=O)N(C2=O)SC(C(Cl)Cl)(Cl)Cl
Question about this molecule: What is the odor of this molecule?
Option A: It has a distinct, pungent odor.
Option B: It has a slightly pungent odor.
Option C: It has a slight, but pungent odor.
Option D: It has a sharp, pungent odor.
"	C
83975	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(=CC1C(C1(C)C)C(=O)OCN2C(=O)C3=C(C2=O)CCCC3)C
Question about this molecule: What is the odor of this molecule?
Option A: It has a slight unpleasant odor.
Option B: It has a slight odor.
Option C: It has a slight aromatic odor.
Option D: It has a slight sulfurous odor.
"	B
6616	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(C2CCC(C2)C1=C)C
Question about this molecule: What is the odor of this molecule?
Option A: It has a very faint aromatic or phenolic odor.
Option B: It has an insipid camphor-like odor.
Option C: It has a sweet chloroform-like odor.
Option D: It has a mild non-residual odor.
"	B
10423	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1COC1
Question about this molecule: What is the odor of this molecule?
Option A: It has an objectionable odor.
Option B: It has an irritating odor.
Option C: It has an agreeable aromatic odor.
Option D: It has an agreeable odor.
"	C
3224	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C2C(COS(=O)O1)C3(C(=C(C2(C3(Cl)Cl)Cl)Cl)Cl)Cl
Question about this molecule: What is the odor of this molecule?
Option A: It has a pungent odor of chlorine.
Option B: It has a distinct, pungent odor.
Option C: It has a pungent odor.
Option D: It has a pungent, irritating odor.
"	C
5281855	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=C2C3=C(C(=C1O)O)OC(=O)C4=CC(=C(C(=C43)OC2=O)O)O
Question about this molecule: What is the odor of this molecule?
Option A: It is usually odorless.
Option B: It is odorless.
Option C: It is essentially odorless.
Option D: It is practically odorless.
"	B
39385	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)(C)C(=O)C(N1C=NC=N1)OC2=CC=C(C=C2)Cl
Question about this molecule: What is the odor of this molecule?
Option A: It has a slight odor.
Option B: It has a slight unpleasant odor.
Option C: It has a slight sulfurous odor.
Option D: It has a slight aromatic odor.
"	A
7594	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)NC(=NC2=CC=CC=C2)N
Question about this molecule: What is the odor of this molecule?
Option A: It has a slight odor.
Option B: It has a slight sulfurous odor.
Option C: It has a slight aromatic odor.
Option D: It has a slight unpleasant odor.
"	A
39676	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(C(=O)N(C(=O)O1)C2=CC(=CC(=C2)Cl)Cl)C=C
Question about this molecule: What is the odor of this molecule?
Option A: It has a slight sulfurous odor.
Option B: It has a slight aromatic odor.
Option C: It has a slight odor.
Option D: It has a slight unpleasant odor.
"	B
13981	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC(=CC(=C1)N=NC2=C(C=C(C=C2)N)N)N=NC3=C(C=C(C=C3)N)N
Question about this molecule: What is the odor of this molecule?
Option A: It is practically odorless.
Option B: It is essentially odorless.
Option C: It is usually odorless.
Option D: It is odorless.
"	D
285033	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)(CCC[C@@](CC(=O)OC)(C(=O)O[C@H]1[C@H]2C3=CC4=C(C=C3CCN5[C@@]2(CCC5)C=C1OC)OCO4)O)O
Question about this molecule: How is the pharmacological activity of this molecule
Option A: It exerts activity against more resistant gram-negative bacilli such as Acinetobacter baumanii and Pseudomonas aeruginosa.
Option B: It carries some activity against protozoans, and has been used off-label in the treatment of toxoplasmosis, malaria, and babesiosis.
Option C: It has major activity against mycobacteria, commonly used in combination with other agents as therapy of tuberculosis.
Option D: It is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies.
"	D
5288783	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H](/C=C/[C@H](C1CC1)O)[C@H]2CC[C@@H]\\3[C@@]2(CCC/C3=C\\C=C/4\\C[C@H](C[C@@H](C4=C)O)O)C
Question about this molecule: How is the pharmacological activity of this molecule
Option A: It is less than 1% as active as the calcitriol in regulating calcium metabolism.
Option B: It has major activity against mycobacteria, commonly used in combination with other agents as therapy of tuberculosis.
Option C: It is investigated for its use in treating cardiovascular disease and its activity against Severe Acute Respiratory Syndrome (SARS).
Option D: It activates the vanilloid receptor in a subpopulation of primary afferent sensory neurons involved in nociception.
"	A
9552079	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC(=CC=C1N/C(=N/C(=NCCCCCCN=C(/N=C(/NC2=CC=C(C=C2)Cl)\\N)N)N)/N)Cl
Question about this molecule: How is the pharmacological activity of this molecule
Option A: It has major activity against mycobacteria, commonly used in combination with other agents as therapy of tuberculosis.
Option B: It carries activity against a broad range of pathogens including bacteria, yeasts, and viruses.
Option C: It carries some activity against protozoans, and has been used off-label in the treatment of toxoplasmosis, malaria, and babesiosis.
Option D: It exerts activity against more resistant gram-negative bacilli such as Acinetobacter baumanii and Pseudomonas aeruginosa.
"	B
135398735	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1/C=C/C=C(\\C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)[C@](O4)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)/C=N/N5CCN(CC5)C)/C
Question about this molecule: How is the pharmacological activity of this molecule
Option A: It exerts activity against more resistant gram-negative bacilli such as Acinetobacter baumanii and Pseudomonas aeruginosa.
Option B: It has major activity against mycobacteria, commonly used in combination with other agents as therapy of tuberculosis.
Option C: It carries some activity against protozoans, and has been used off-label in the treatment of toxoplasmosis, malaria, and babesiosis.
Option D: It is investigated for its use in treating cardiovascular disease and its activity against Severe Acute Respiratory Syndrome (SARS).
"	B
29029	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC[C@@H]1C[C@H](N(C1)C)C(=O)NC([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)C(C)Cl
Question about this molecule: How is the pharmacological activity of this molecule
Option A: It carries some activity against protozoans, and has been used off-label in the treatment of toxoplasmosis, malaria, and babesiosis.
Option B: It exerts activity against more resistant gram-negative bacilli such as Acinetobacter baumanii and Pseudomonas aeruginosa.
Option C: It has major activity against mycobacteria, commonly used in combination with other agents as therapy of tuberculosis.
Option D: It is investigated for its use in treating cardiovascular disease and its activity against Severe Acute Respiratory Syndrome (SARS).
"	A
5479530	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1C(=NC(=O)C(=O)N1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\\OC)/C4=CSC(=N4)N)SC2)C(=O)O
Question about this molecule: How is the pharmacological activity of this molecule
Option A: It carries some activity against protozoans, and has been used off-label in the treatment of toxoplasmosis, malaria, and babesiosis.
Option B: It has good activity against multi-drug resistant Enterobacteriaceae, a relatively safe adverse effect profile, and a long half-life which allows for the convenience of daily or twice-daily dosing.
Option C: It exerts activity against more resistant gram-negative bacilli such as Acinetobacter baumanii and Pseudomonas aeruginosa.
Option D: It has major activity against mycobacteria, commonly used in combination with other agents as therapy of tuberculosis.
"	B
4763	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC1(C(=O)NC(=O)NC1=O)C2=CC=CC=C2
Question about this molecule: What is the physical state of this molecule?
Option A: It appears as a colorless liquid.
Option B: It appears as a liquid.
Option C: It is a clear liquid.
Option D: It is a liquid.
"	D
36314	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
Question about this molecule: What is the physical state of this molecule?
Option A: It is a colorless crystalline solid.
Option B: It appears as a colorless crystalline solid.
Option C: It is a crystalline solid.
Option D: It is a solid.
"	D
5983	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@]12CCN([C@@H]1N(C3=C2C=C(C=C3)OC(=O)NC)C)C
Question about this molecule: What is the physical state of this molecule?
Option A: It is a white crystalline powder.
Option B: It is a crystalline powder.
Option C: It is a white powder.
Option D: It is a powder.
"	D
11463	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CCC(=C(C)C)CC1
Question about this molecule: What is the physical state of this molecule?
Option A: It appears as a colorless liquid.
Option B: It appears as a liquid.
Option C: It is a liquid.
Option D: It is a clear liquid.
"	C
15938	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[N+]1=CC=C(C=C1)C2=CC=[N+](C=C2)C.[Cl-].[Cl-]
Question about this molecule: What is the physical state of this molecule?
Option A: It is a colorless to pale yellow crystalline solid.
Option B: It appears as a colorless to pale yellow liquid.
Option C: It is a colorless to yellow crystalline solid.
Option D: It occurs as a colorless to pale yellow solid.
"	C
17038	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C=CCC2C1C(=O)N(C2=O)SC(C(Cl)Cl)(Cl)Cl
Question about this molecule: What is the physical state of this molecule?
Option A: It is a white crystalline solid.
Option B: It is a fine white crystalline solid.
Option C: It is a white crystalline powder or solid.
Option D: It is a white crystalline powder.
"	A
4060	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC1(C(=O)N(C(=O)N1)C)C2=CC=CC=C2
Question about this molecule: What is the physical state of this molecule?
Option A: It is a solid.
Option B: It appears as a colorless crystalline solid.
Option C: It is a crystalline solid.
Option D: It is a colorless crystalline solid.
"	A
6616	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(C2CCC(C2)C1=C)C
Question about this molecule: What is the physical state of this molecule?
Option A: It is a colorless to white crystalline solid.
Option B: It appears as a colorless to white crystalline solid.
Option C: It appears as a colorless to white lustrous solid.
Option D: It is a colorless to pale yellow crystalline solid.
"	B
10423	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1COC1
Question about this molecule: What is the physical state of this molecule?
Option A: It is a dense colorless liquid.
Option B: It is a clear, colorless liquid.
Option C: It is a clear colorless liquid.
Option D: It appears as a clear colorless liquid.
"	B
8606	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C=CCC2C1C(=O)N(C2=O)SC(Cl)(Cl)Cl
Question about this molecule: What is the physical state of this molecule?
Option A: It is a water emulsifiable liquid.
Option B: It is a water-white mobile liquid.
Option C: It is a colorless watery liquid.
Option D: It appears as a water-white liquid.
"	A
3224	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C2C(COS(=O)O1)C3(C(=C(C2(C3(Cl)Cl)Cl)Cl)Cl)Cl
Question about this molecule: What is the physical state of this molecule?
Option A: It appears as a brown or colorless crystalline solid.
Option B: It occurs as a colorless to pale yellow solid.
Option C: It is a colorless to yellow crystalline solid.
Option D: It is a colorless to pale yellow crystalline solid.
"	A
39385	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)(C)C(=O)C(N1C=NC=N1)OC2=CC=C(C=C2)Cl
Question about this molecule: What is the physical state of this molecule?
Option A: It is a colorless to pale yellow crystalline solid.
Option B: It appears as a colorless to pale yellow liquid.
Option C: It occurs as a colorless to pale yellow solid.
Option D: It is a colorless to yellow crystalline solid.
"	A
1986	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(=O)NC1=NN=C(S1)S(=O)(=O)N
Question about this molecule: What is the physical state of this molecule?
Option A: It is an odorless white to slightly yellow crystalline powder.
Option B: It is an odorless white to off-white microcrystalline powder.
Option C: It is an odorless white to off-white crystalline powder.
Option D: It appears as white to yellowish-white fine crystalline powder.
"	D
7594	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)NC(=NC2=CC=CC=C2)N
Question about this molecule: What is the physical state of this molecule?
Option A: It appears as white to pale cream-colored crystalline powder.
Option B: It is a white to cream-colored chalky powder.
Option C: It is an odorless white to off-white microcrystalline powder.
Option D: It is an odorless white to light-yellow crystalline powder.
"	B
39676	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(C(=O)N(C(=O)O1)C2=CC(=CC(=C2)Cl)Cl)C=C
Question about this molecule: What is the physical state of this molecule?
Option A: It appears as golden crystals.
Option B: It appears as white crystals.
Option C: It appears as colorless monoclinic crystals.
Option D: It appears as colorless crystals.
"	D
13981	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC(=CC(=C1)N=NC2=C(C=C(C=C2)N)N)N=NC3=C(C=C(C=C3)N)N
Question about this molecule: What is the physical state of this molecule?
Option A: It is a clear light yellow to dark brown viscous liquid.
Option B: It is an odorless dark purple to blackish-brown powder.
Option C: It is a dark, yellow, oily liquid.
Option D: It is a deep purple to dark blue microcrystalline powder.
"	B
9549196	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CCC2=NC3=CC=CC=C3C(=C2C1)NCCCCCCCNC4=C5CCCCC5=NC6=CC=CC=C64
Question about this molecule: Which kind of potency does this molecule have/exhibit?
Option A: It is an acetylcholinesterase (AChE) inhibitor (IC50 0.40 nM, >1,000 times more potent than tacrine).
Option B: It is a potent inhibitor of salt-inducible kinase 2, a potential target protein for therapy in ovarian cancer.
Option C: It is 2 fold more potent against cyclin dependent kinase 5 (CDK5) and >150 times more potent against CDK1.
Option D: It is a cell-permeable, potent and selective agonist of the TRPV4 (transient receptor potential vanilloid 4) channel.
"	A
71312006	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NC3=CC=CC(=C3)C4=CC=CC=N4.O.Cl
Question about this molecule: Which kind of potency does this molecule have/exhibit?
Option A: It is a potent inhibitor of salt-inducible kinase 2, a potential target protein for therapy in ovarian cancer.
Option B: It is a cell-permeable, potent and selective agonist of the TRPV4 (transient receptor potential vanilloid 4) channel.
Option C: It is an acetylcholinesterase (AChE) inhibitor (IC50 0.40 nM, >1,000 times more potent than tacrine).
Option D: It is 2 fold more potent against cyclin dependent kinase 5 (CDK5) and >150 times more potent against CDK1.
"	D
23630211	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)C[C@@H](C(=O)N1CCN(CC1)C(=O)[C@H](CO)NS(=O)(=O)C2=C(C=C(C=C2)Cl)Cl)NC(=O)C3=CC4=CC=CC=C4S3
Question about this molecule: Which kind of potency does this molecule have/exhibit?
Option A: It is a cell-permeable, potent and selective agonist of the TRPV4 (transient receptor potential vanilloid 4) channel.
Option B: It is a potent inhibitor of salt-inducible kinase 2, a potential target protein for therapy in ovarian cancer.
Option C: It is 2 fold more potent against cyclin dependent kinase 5 (CDK5) and >150 times more potent against CDK1.
Option D: It is an acetylcholinesterase (AChE) inhibitor (IC50 0.40 nM, >1,000 times more potent than tacrine).
"	A
49846579	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN=C8C(=C7)C=CN8)C
Question about this molecule: What is the potency of this molecule?
Option A: It is three times more potent than desflurane, but has lower potency compared to halothane and isoflurane.
Option B: It is approximately 10 times more potent than navitoclax with regard to induction of apoptosis in CLL cells.
Option C: It possesses greater potency than endogenous LHRH and reversibly represses gonadotropin secretion.
Option D: It has a significantly higher barrier to resistance than the first generation NS5A inhibitors, making it a highly potent and reliable alternative for treatment of chronic Hepatitis C.
"	B
5311309	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)C1CCC(CC1)C(=O)N[C@H](CC2=CC=CC=C2)C(=O)O
Question about this molecule: What is the potency of this molecule?
Option A: DHT is approximately 30 times more potent than testosterone.
Option B: It is approximately 150 times more potent than citalopram's R-enantiomer.
Option C: It is estimated to be between 400-6000 times more potent than morphine in certain cases.
Option D: It appears to be more effective at lowering postprandial blood glucose.
"	D
62887	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[N@@+]1(CCC2=CC(=C(C=C2[C@H]1CC3=CC(=C(C=C3)OC)OC)OC)OC)CCC(=O)OCCCCCOC(=O)CC[N@+]4(CCC5=CC(=C(C=C5[C@H]4CC6=CC(=C(C=C6)OC)OC)OC)OC)C
Question about this molecule: What is the potency of this molecule?
Option A: It is three times more potent than desflurane, but has lower potency compared to halothane and isoflurane.
Option B: It is approximately 10 times more potent than navitoclax with regard to induction of apoptosis in CLL cells.
Option C: It is approximately 13 per cent less potent (by molarity) than racemic bupivacaine.
Option D: It has approximately 3 times its neuromuscular blocking potency.
"	D
67683363	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1CC[C@H](N1C(=O)[C@H](C(C)C)NC(=O)OC)C2=NC3=C(N2)C=CC4=CC5=C(C=C43)OCC6=C5C=CC(=C6)C7=CN=C(N7)[C@@H]8C[C@@H](CN8C(=O)[C@@H](C9=CC=CC=C9)NC(=O)OC)COC
Question about this molecule: What is the potency of this molecule?
Option A: It is approximately 10 times more potent than navitoclax with regard to induction of apoptosis in CLL cells.
Option B: It possesses greater potency than endogenous LHRH and reversibly represses gonadotropin secretion.
Option C: It is three times more potent than desflurane, but has lower potency compared to halothane and isoflurane.
Option D: It has a significantly higher barrier to resistance than the first generation NS5A inhibitors, making it a highly potent and reliable alternative for treatment of chronic Hepatitis C.
"	D
3476	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC1=C(CN(C1=O)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)C)C
Question about this molecule: What is the potency of this molecule?
Option A: It mimics the actions of endogenous progesterone with a greater potency.
Option B: It is one of the most potent opioids known (also the most potent opioid used commercially).
Option C: It is considered to be a useful, cost-effective treatment option for managing type 2 diabetes mellitus.
Option D: It is the most potent DAC inhibiting agent available on the market.
"	C
62751	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CCC(CC1)(C2=CC=CS2)N3CCCCC3
Question about this molecule: What is the potency of this molecule?
Option A: It is more potent and addicting than codeine.
Option B: It is more potent than phencyclidine and classified under schedule 1.
Option C: It is more potent than morphine.
Option D: It is more potent and more addicting than codeine by weight.
"	B
6450551	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=CC=N4
Question about this molecule: What is the potency of this molecule?
Option A: It exhibits potency that is 50-450 times higher than that of the first generation VEGFR inhibitors.
Option B: It is three times more potent than desflurane, but has lower potency compared to halothane and isoflurane.
Option C: It is approximately 10 times more potent than navitoclax with regard to induction of apoptosis in CLL cells.
Option D: It is approximately 13 per cent less potent (by molarity) than racemic bupivacaine.
"	A
9871419	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCSC1=NC(=C2C(=N1)N(N=N2)[C@@H]3C[C@@H]([C@H]([C@H]3O)O)OCCO)N[C@@H]4C[C@H]4C5=CC(=C(C=C5)F)F
Question about this molecule: Which kind of reaction can this molecule cause?
Option A: It can be linked to rare instances of hypersensitivity reactions accompanied by mild liver injury.
Option B: It can cause allergic reactions, although only rarely.
Option C: It can cause hypersensitivity reactions, some of which are accompanied by liver injury which is typically cholestatic.
Option D: It can be associated with the risk of developing allergic reactions in some high-risk patients, such as those with asthma.
"	A
441290	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(=O)O[C@H]1[C@H](C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(C[C@@H]([C@H](C4)O)N5CCOCC5)C)C)[N+]6(CCCC6)CC=C
Question about this molecule: Which kind of reaction can this molecule cause?
Option A: It can cause hypersensitivity reactions, some of which are accompanied by liver injury which is typically cholestatic.
Option B: It can cause allergic reactions, although only rarely.
Option C: It can be associated with the risk of developing allergic reactions in some high-risk patients, such as those with asthma.
Option D: It can be linked to rare instances of hypersensitivity reactions accompanied by mild liver injury.
"	C
11497466	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OC)N5CCN(CC5)C.Cl
Question about this molecule: Which kind of receptor activity does this molecule have/exhibit?
Option A: It is a potent and selective 5-HT1A receptor partial agonist.
Option B: It is a noncompetitive AMPA glutamate receptor antagonist.
Option C: It is a highly potent, competitive, preferential dopamine D3 receptor antagonist.
Option D: It displays potent and selective 5-HT1B/1D receptor antagonist activity.
"	D
107780	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OC)N5CCN(CC5)C
Question about this molecule: Which kind of receptor activity does this molecule have/exhibit?
Option A: It is a noncompetitive AMPA glutamate receptor antagonist.
Option B: It is a potent and selective 5-HT1A receptor partial agonist.
Option C: It is a highly potent, competitive, preferential dopamine D3 receptor antagonist.
Option D: It displays potent and selective 5-HT1B/1D receptor antagonist activity.
"	D
91273	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C[C@H]2C[C@@H]1[C@H]3[C@@H]2C(=O)N(C3=O)CCCCN4CCN(CC4)C5=NC=CC=N5
Question about this molecule: Which kind of receptor activity does this molecule have/exhibit?
Option A: It displays potent and selective 5-HT1B/1D receptor antagonist activity.
Option B: It is a potent and selective 5-HT1A receptor partial agonist.
Option C: It is a highly potent, competitive, preferential dopamine D3 receptor antagonist.
Option D: It is a noncompetitive AMPA glutamate receptor antagonist.
"	B
3408722	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCCN1CCCC1CNC(=O)C2=C(C3=CC=CC=C3C(=C2)C#N)OC
Question about this molecule: Which kind of receptor activity does this molecule have/exhibit?
Option A: It is a noncompetitive AMPA glutamate receptor antagonist.
Option B: It is a potent and selective 5-HT1A receptor partial agonist.
Option C: It displays potent and selective 5-HT1B/1D receptor antagonist activity.
Option D: It is a highly potent, competitive, preferential dopamine D3 receptor antagonist.
"	D
9924495	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)N2C=C(C=C(C2=O)C3=CC=CC=C3C#N)C4=CC=CC=N4
Question about this molecule: Which kind of receptor activity does this molecule have/exhibit?
Option A: It is an NMDA receptor antagonist.
Option B: It is a noncompetitive AMPA glutamate receptor antagonist.
Option C: It is a highly potent, competitive, preferential dopamine D3 receptor antagonist.
Option D: It displays potent and selective 5-HT1B/1D receptor antagonist activity.
"	B
60795	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CC(=O)NC2=C1C=CC(=C2)OCCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl
Question about this molecule: Which kind of receptor activity does this molecule have/exhibit?
Option A: It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT1A receptors and as an antagonist at serotonin 5-HT2A receptors.
Option B: It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors.
Option C: It acts as an agonist of κ- and σ-opioid receptors, as an antagonist of the N-methyl-D-aspartate (NMDA) receptor, and as an inhibitor of serotonin and norepinephrine uptake.
Option D: It has partial agonist activity at the D2 receptor, partial agonist activity at the 5-HT1A receptor, and antagonist profile at the 5-HT2A receptor.
"	D
5310966	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1[C@@H]2CNC[C@H]1C3=CC4=NC=CN=C4C=C23
Question about this molecule: Which kind of receptor activity does this molecule have/exhibit?
Option A: It is a non-selective α- and β-adrenergic receptor agonist.
Option B: It is an alpha adrenergic receptor agonist (primarily alpha-2).
Option C: It is an alpha- and beta-adrenergic receptor agonist.
Option D: It acts on alpha3/beta4 and weakly on alpha3beta2 and alpha6-containing receptors.
"	D
135398737	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Question about this molecule: Which kind of receptor antagonist is this molecule?
Option A: It acts on dopamine receptors.
Option B: It is an oral dopamine receptor agonist.
Option C: It stimulates dopamine D2 receptors.
Option D: It shows weak antagonism at the dopamine D2 receptor.
"	D
6451149	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC=CC=C1C2=CC(=NC=C2N(C)C(=O)C(C)(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CCN(CC4)C
Question about this molecule: Which kind of receptor antagonist is this molecule?
Option A: It is a D1 and D2 receptor antagonist.
Option B: It is a neurokinin 1 receptor antagonist.
Option C: It acts as an OP1 receptor agonist.
Option D: It is an NMDA receptor antagonist.
"	B
11250029	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=CC(=C1C[C@@H](C(=O)N(CC2=CC(=C(C=C2)OC)C(=O)O)[C@@H](C)C3=NC=C(N3)C4=CC=CC=C4)N)C)C(=O)N
Question about this molecule: Which kind of receptor antagonist is this molecule?
Option A: It acts as a neurotransmitter via a G protein-coupled receptor with high affinity for this molecule called TA1.
Option B: It increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors.
Option C: It affects mu-, kappa-, and delta-opioid receptors.
Option D: It blocks serotonin reuptake and increases serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors.
"	C
6087	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)C3=C(C=CC=C3OC)OC)C(=O)O)C
Question about this molecule: What is the right information about this molecule's resistance?
Option A: It is highly resistant to a broad spectrum of beta-lactamases.
Option B: Most grasses are resistant to it.
Option C: It is resistant to penicillinase.
Option D: It is resistant to beta-lactamases.
"	C
6918485	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@H](C1=NC(=CS1)C2=CC=C(C=C2)C#N)[C@](CN3C=NC=N3)(C4=C(C=CC(=C4)F)F)O
Question about this molecule: What is the right information about this molecule's resistance?
Option A: It remains a valuable option in the face of growing resistance to front-line antibiotics such as β-lactams and cephalosporins.
Option B: Resistance to this molecule has been associated with the mutation in the target gene CYP51.
Option C: It can cause resistance in insects with certain mutations in their sodium channel gene to pyrethroid insecticides.
Option D: Insects with certain mutations in their sodium channel gene may be resistant to pyrethroid insecticides.
"	B
446596	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]([C@H]1[C@@H](O1)C[C@H]2CO[C@H]([C@@H]([C@@H]2O)O)C/C(=C/C(=O)OCCCCCCCCC(=O)O)/C)[C@H](C)O
Question about this molecule: What is the right information about this molecule's resistance?
Option A: It remains a valuable option in the face of growing resistance to front-line antibiotics such as β-lactams and cephalosporins.
Option B: It is resistant to enzymatic hydrolysis by some general proteases, such as pepsin, trypsin, collagenase, and chymotrypsin.
Option C: Mupirocin does not demonstrate cross-resistance with other classes of antimicrobial agents.
Option D: Treatment with first-generation EGFR-TKIs has been associated with the development of resistance through activating mutations in the EGFR gene.
"	C
10324367	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1([C@@H]2[C@H]1[C@H](N(C2)C(=O)[C@H](C(C)(C)C)NC(=O)NC(C)(C)C)C(=O)NC(CC3CCC3)C(=O)C(=O)N)C
Question about this molecule: What is the right information about this molecule's resistance?
Option A: It has a significantly higher barrier to resistance than the first generation NS5A inhibitors, such as [DB09027] and [DB09102].
Option B: Treatment with first-generation EGFR-TKIs has been associated with the development of resistance through activating mutations in the EGFR gene.
Option C: The barrier to the development of resistance to NS5A inhibitors is lower than that of NS5B inhibitors.
Option D: The barrier for development of resistance to NS3/4A inhibitors is lower than that of NS5B inhibitors.
"	D
91768	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)[C@H](C(=O)OC(C#N)C1=CC(=CC=C1)OC2=CC=CC=C2)NC3=C(C=C(C=C3)C(F)(F)F)Cl
Question about this molecule: What is the right information about this molecule's resistance?
Option A: Insects with certain mutations in their sodium channel gene may be resistant to pyrethroid insecticides.
Option B: It remains a valuable option in the face of growing resistance to front-line antibiotics such as β-lactams and cephalosporins.
Option C: It can cause resistance in insects with certain mutations in their sodium channel gene to pyrethroid insecticides.
Option D: The barrier for development of resistance to NS3/4A inhibitors is lower than that of NS5B inhibitors.
"	C
6438357	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)C(=C)N(C(=O)CC[C@@H](NC1=O)C(=O)O)C)C)CCCN=C(N)N)C(=O)O)C)CCCN=C(N)N)/C=C/C(=C/[C@H](C)[C@H](CC2=CC=CC=C2)OC)/C
Question about this molecule: What is the right information about this molecule's resistance?
Option A: It is resistant to enzymatic hydrolysis by some general proteases, such as pepsin, trypsin, collagenase, and chymotrypsin.
Option B: The barrier for development of resistance to NS3/4A inhibitors is lower than that of NS5B inhibitors.
Option C: It has a significantly higher barrier to resistance than the first generation NS5A inhibitors, such as [DB09027] and [DB09102].
Option D: Treatment with first-generation EGFR-TKIs has been associated with the development of resistance through activating mutations in the EGFR gene.
"	A
67683363	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1CC[C@H](N1C(=O)[C@H](C(C)C)NC(=O)OC)C2=NC3=C(N2)C=CC4=CC5=C(C=C43)OCC6=C5C=CC(=C6)C7=CN=C(N7)[C@@H]8C[C@@H](CN8C(=O)[C@@H](C9=CC=CC=C9)NC(=O)OC)COC
Question about this molecule: What is the right information about this molecule's resistance?
Option A: The barrier for development of resistance to NS3/4A inhibitors is lower than that of NS5B inhibitors.
Option B: Treatment with first-generation EGFR-TKIs has been associated with the development of resistance through activating mutations in the EGFR gene.
Option C: The barrier to the development of resistance to NS5A inhibitors is lower than that of NS5B inhibitors.
Option D: It has a significantly higher barrier to resistance than the first generation NS5A inhibitors, such as [DB09027] and [DB09102].
"	D
57379345	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=C(C=C1C2CCNCC2)OC(C)C)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)C(C)C)Cl
Question about this molecule: What is the right information about this molecule's resistance?
Option A: Treatment with first-generation EGFR-TKIs has been associated with the development of resistance through activating mutations in the EGFR gene.
Option B: It has a significantly higher barrier to resistance than the first generation NS5A inhibitors, such as [DB09027] and [DB09102].
Option C: Most tumors develop drug resistance to it following treatment with crizotinib due to mutations in key ""gatekeeper"" residues of the enzyme.
Option D: It is resistant to enzymatic hydrolysis by some general proteases, such as pepsin, trypsin, collagenase, and chymotrypsin.
"	C
445434	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)C(=C)N(C(=O)CC[C@@H](NC1=O)C(=O)O)C)C)CC(C)C)C(=O)O)C)CCCN=C(N)N)/C=C/C(=C/[C@H](C)[C@H](CC2=CC=CC=C2)OC)/C
Question about this molecule: What is the right information about this molecule's resistance?
Option A: It is resistant to enzymatic hydrolysis by some general proteases, such as pepsin, trypsin, collagenase, and chymotrypsin.
Option B: It has a significantly higher barrier to resistance than the first generation NS5A inhibitors, such as [DB09027] and [DB09102].
Option C: Treatment with first-generation EGFR-TKIs has been associated with the development of resistance through activating mutations in the EGFR gene.
Option D: The barrier for development of resistance to NS3/4A inhibitors is lower than that of NS5B inhibitors.
"	A
9915743	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)/C=C/CN(C)C
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It is associated with a moderate rate of transient elevations in serum aminotransferase during therapy, but has not been linked to instances of clinically apparent liver injury.
Option B: It is associated with a low rate of transient elevations in serum aminotransferase levels during therapy, but has not been convincingly linked to cases of clinically apparent liver injury with jaundice.
Option C: It is associated with transient and usually mild elevations in serum aminotransferase during therapy, but has not been convincingly linked to cases of clinically apparent liver injury.
Option D: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of acute, clinically apparent liver injury.
"	B
25077993	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC2=CN(C=N2)CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has been linked to a low rate of serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury.
Option B: It is associated with a low rate of transient serum enzyme elevations during therapy, but has not been linked convincingly to cases of clinically apparent acute liver injury.
Option C: It is associated with a low rate of transient serum enzyme elevations during treatment, but has not been implicated in cases of clinically apparent acute liver injury.
Option D: It is associated with a low rate of transient serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury with jaundice.
"	B
24775005	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@H]1CN(C[C@@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It is associated with a low rate of serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent acute liver injury.
Option B: It is associated with a low rate or transient serum aminotransferase elevations during therapy, but has not been linked to instances of clinically apparent acute liver injury.
Option C: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of clinically apparent acute liver injury.
Option D: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of acute, clinically apparent liver injury.
"	B
6005	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CCC2=C3[C@H]1CC4=C(C3=CC=C2)C(=C(C=C4)O)O
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury.
Option B: It has not been associated with serum enzyme elevations during treatment nor to instances of clinically apparent acute liver injury.
Option C: It has not been associated with serum enzyme elevations during treatment and has not been linked to cases of clinically apparent acute liver injury.
Option D: It has not been associated with serum enzyme elevations during treatment nor has it been implicated in cases of acute liver injury.
"	D
9924495	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)N2C=C(C=C(C2=O)C3=CC=CC=C3C#N)C4=CC=CC=N4
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been associated with serum aminotransferase or alkaline phosphatase elevations, and clinically apparent liver injury from it has not been reported and must be very rare, if it occurs at all.
Option B: It has not been associated with serum aminotransferase or alkaline phosphatase elevations, and clinically apparent liver injury from it has been reported, but is very rare.
Option C: Therapy with it has not been associated with serum aminotransferase elevations, and clinically apparent liver injury from it has yet to be reported and must be rare, if it occurs at all.
Option D: It has not been associated with serum aminotransferase elevations during therapy, and clinically apparent liver injury from this molecule has yet to be reported and must be rare, if it occurs at all.
"	D
9931954	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=C3C(=CC(=C4)F)N2
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It is associated with a moderate rate of transient elevations in serum aminotransferase during therapy, but has not been linked to instances of clinically apparent liver injury.
Option B: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of acute, clinically apparent liver injury.
Option C: It is associated with transient and usually mild elevations in serum aminotransferase during therapy, but has not been convincingly linked to cases of clinically apparent liver injury.
Option D: It is associated with a low rate of transient elevations in serum aminotransferase levels during therapy, but has not been convincingly linked to cases of clinically apparent liver injury with jaundice.
"	A
3042	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been associated with serum enzyme elevations or clinically apparent liver injury.
Option B: It has not been implicated in causing serum enzyme elevations or clinically apparent liver injury.
Option C: It has not been linked to either serum enzyme elevations or to clinically apparent acute liver injury.
Option D: It has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury.
"	D
36314	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It is associated with a low rate of transient serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury with jaundice.
Option B: It is associated with a low rate of transient serum enzyme elevations during treatment, but has not been implicated in cases of clinically apparent acute liver injury.
Option C: Therapy with it has been associated with a low rate of serum enzyme elevations, but has not been clearly linked to cases of clinically apparent acute liver injury.
Option D: It has been linked to a low rate of serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury.
"	C
6918248	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CN(CCN1CCN2C3=CC=CC=C3NC2=O)C4=CC=CC(=C4)C(F)(F)F
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has been associated with a low rate of minor serum aminotransferase elevations during treatment, but has not been linked to instances of clinically apparent acute liver injury.
Option B: It is associated with a low rate of serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent acute liver injury.
Option C: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of acute, clinically apparent liver injury.
Option D: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of clinically apparent acute liver injury.
"	A
37542	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=NC(=NN1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(=O)N
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been associated with clinically apparent liver injury.
Option B: It has not been associated with instances of clinically apparent liver injury.
Option C: It has not been linked to instances of clinically apparent liver injury.
Option D: It has not been linked to episodes of clinically apparent liver injury.
"	A
26987	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@](C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCC[C@H]3CCCN3C
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been linked to instances of clinically apparent, acute liver injury.
Option B: It has not been associated with instances of clinically apparent liver injury.
Option C: It has not been linked to instances of clinically apparent liver injury.
Option D: It has not been linked to instances of clinically apparent acute liver injury.
"	D
708857	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CCCN=C1/C=C/C2=CC=CS2
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been associated with serum aminotransferase elevations nor with clinically apparent liver injury.
Option B: It has not been associated with serum aminotransferase elevations and clinically apparent liver injury.
Option C: It has not been reported to cause serum aminotransferase elevations or clinically apparent liver injury.
Option D: It has not been associated with serum aminotransferase elevations or cases of clinically apparent acute liver injury.
"	C
3152	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It is associated with a minimal rate of serum enzyme elevations during therapy and has only rarely been implicated as a cause of clinically apparent liver injury.
Option B: It is associated with a low rate of transient serum enzyme elevations during treatment, but has not been implicated in cases of clinically apparent acute liver injury.
Option C: It is associated with a low rate of serum enzyme elevations during treatment and has been implicated in rare instances of clinically apparent, acute liver injury.
Option D: It is associated with a minimal rate of serum enzyme elevations during therapy and has only rarely been implicated as a cause of clinically apparent acute liver injury.
"	A
2099	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(N=CN1)CN2CCC3=C(C2=O)C4=CC=CC=C4N3C
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It was not linked to instances of acute liver injury during therapy but, when combined with peginterferon and ribavirin, was associated with cases of hepatic decompensation in patients with preexisting cirrhosis.
Option B: It has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury, but the combination with acetaminophen has been linked to many cases of acute liver failure due to unintentional overdose with acetaminophen.
Option C: It is more potent and is safer than the synthetic estrogen ethinylestradiol (EE2) found in 97% of oral contraceptive pills, reducing the environmental accumulation of unwanted endocrine disrupting chemicals (EDCs) that often lead to harmful epigenetic effects.
Option D: It was voluntarily withdrawn from the US market in November 2000 by the manufacturer due to numerous reports of severe adverse effects including ischemic colitis, severely obstructed or ruptured bowel, and death.
"	D
9574101	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCOC(=O)CN[C@H](C1CCCCC1)C(=O)N2CC[C@H]2C(=O)NCC3=CC=C(C=C3)/C(=N/O)/N
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It does not appear to be a significant cause of drug induced liver injury, but can be associated with flares of the underlying hepatitis B either during therapy or upon withdrawal.
Option B: It does not appear to be a significant cause of drug-induced liver injury, but initiation of therapy and sudden withdrawal of therapy can induce a transient exacerbation of the underlying hepatitis B.
Option C: It was discontinued in 2003 in some countries due to the small possibility of hepatic (liver) injury, which could lead to the need for a liver transplant, or even death.
Option D: It has hepatotoxicity (liver damage) and its distribution was discontinued in countries where the drug had been approved.
"	D
134018	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(SC(=N1)C2=CC(=C(C=C2)OCC(C)C)C#N)C(=O)O
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been associated with serum aminotransferase elevations and has not been linked to cases of clinically apparent liver injury.
Option B: It has been associated with minor serum aminotransferase elevations, but has yet to be linked to cases of clinically apparent acute liver injury.
Option C: It has not been associated with serum aminotransferase elevations or cases of clinically apparent acute liver injury.
Option D: Therapy has not been associated consistently with serum aminotransferase elevations and has yet to be linked to cases of clinically apparent acute liver injury.
"	B
11561674	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCOC1=C(C=CC(=C1)[C@@H](CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It is associated with a low rate of transient serum enzyme elevations during therapy, but has not been linked convincingly to cases of clinically apparent acute liver injury.
Option B: It has been linked to a low rate of serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury.
Option C: It is associated with a low rate of transient serum enzyme elevations during treatment, but has not been implicated in cases of clinically apparent acute liver injury.
Option D: It is associated with a low rate of transient serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury with jaundice.
"	B
3348	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)(C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O)C(=O)O
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury.
Option B: It has not been linked to significant serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury.
Option C: It has not been found to be associated with serum enzyme elevations during therapy or to instances of clinically apparent liver injury.
Option D: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent liver injury.
"	A
9444	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=NC(=NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It is associated with a low rate of transient serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury with jaundice.
Option B: It is associated with a low rate of transient serum enzyme elevations during treatment, but has not been implicated in cases of clinically apparent acute liver injury.
Option C: It has been linked to a low rate of serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury.
Option D: It is associated with a low rate of transient serum enzyme elevations during therapy and has only rarely been implicated in cases of clinically apparent acute liver injury with jaundice.
"	D
10324367	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1([C@@H]2[C@H]1[C@H](N(C2)C(=O)[C@H](C(C)(C)C)NC(=O)NC(C)(C)C)C(=O)NC(CC3CCC3)C(=O)C(=O)N)C
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It is more potent and is safer than the synthetic estrogen ethinylestradiol (EE2) found in 97% of oral contraceptive pills, reducing the environmental accumulation of unwanted endocrine disrupting chemicals (EDCs) that often lead to harmful epigenetic effects.
Option B: It is frequently associated with serum enzyme elevations, but more importantly, it has been linked to rapid onset, severe hypersensitivity reactions that can be associated with acute hepatic necrosis, liver failure, and death.
Option C: It was not linked to instances of acute liver injury during therapy but, when combined with peginterferon and ribavirin, was associated with cases of hepatic decompensation in patients with preexisting cirrhosis.
Option D: It has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury, but the combination with acetaminophen has been linked to many cases of acute liver failure due to unintentional overdose with acetaminophen.
"	C
71360	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(=O)C1=CC(=C(C=C1)OCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)OC
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of clinically apparent acute liver injury.
Option B: It is associated with a low rate of serum aminotransferase elevations during therapy and has not been linked to instances of clinically apparent acute liver injury.
Option C: It is associated with a low rate of serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent acute liver injury.
Option D: It has a low rate of serum aminotransferase elevations during therapy and has not been linked to instances of clinically apparent acute liver injury.
"	B
9966051	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=C(C=C1)SC2=CC=CC=C2N3CCNCC3)C
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It is associated with a low rate of serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent acute liver injury.
Option B: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of acute, clinically apparent liver injury.
Option C: It has been associated with a low rate of minor serum aminotransferase elevations during treatment, but has not been linked to instances of clinically apparent acute liver injury.
Option D: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of clinically apparent acute liver injury.
"	C
49846579	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN=C8C(=C7)C=CN8)C
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It is associated with a low rate of transient serum enzyme elevations during therapy, but has not been linked convincingly to cases of clinically apparent acute liver injury.
Option B: It is associated with a low rate of transient serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury with jaundice.
Option C: It is associated with a low rate of transient serum enzyme elevations during treatment, but has not been implicated in cases of clinically apparent acute liver injury.
Option D: It has been linked to a low rate of serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury.
"	B
2754	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been associated with serum enzyme elevations during therapy or with published instances of clinically apparent liver injury.
Option B: It has not been found to be associated with serum enzyme elevations during therapy or to instances of clinically apparent liver injury.
Option C: It has not been associated with serum enzyme elevations during therapy or with clinically apparent liver injury.
Option D: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury.
"	A
6918606	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@H](C1=NC(=CS1)C2=CC=C(C=C2)C#N)[C@](CN3C=[N+](C=N3)C(C)OC(=O)N(C)C4=C(C=CC=N4)COC(=O)CNC)(C5=C(C=CC(=C5)F)F)O
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It is associated with a low rate of transient and mild serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent acute liver injury.
Option B: It is associated with a low rate of transient serum aminotransferase elevations and has not been linked to instances of clinically apparent acute liver injury.
Option C: It is associated with a low rate of transient and asymptomatic serum aminotransferase elevations during therapy, but has not been linked to instances of clinically apparent acute drug-induced liver injury.
Option D: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of acute, clinically apparent liver injury.
"	C
74989	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CC(CCC1C2=CC=C(C=C2)Cl)C3=C(C4=CC=CC=C4C(=O)C3=O)O
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has been linked to a low rate of serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury.
Option B: It has a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent acute liver injury.
Option C: Its therapy is associated with low rates of serum enzyme elevations and has been linked to only rare cases of clinically apparent liver injury.
Option D: It has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury.
"	C
119607	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(C(=NO1)C2=CC=CC=C2)C3=CC=C(C=C3)S(=O)(=O)N
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been associated with serum enzyme elevations during therapy or with published instances of clinically apparent liver injury.
Option B: Its therapy is associated with low rates of serum enzyme elevations and has been linked to only rare cases of clinically apparent liver injury.
Option C: It was withdrawn from markets in 2005 due to concerns about a possible increased risk of heart attack and stroke.
Option D: It was withdrawn from the market worldwide following reports of adverse reactions, including reports of carcinogenicity in animal studies.
"	C
5719	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCN(C1=CC=CC(=C1)C2=CC=NC3=C(C=NN23)C#N)C(=O)C
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury.
Option B: It has not been associated with serum enzyme elevations or clinically apparent liver injury.
Option C: It has not been linked to either serum enzyme elevations or to clinically apparent acute liver injury.
Option D: It has not been implicated in causing serum enzyme elevations or clinically apparent liver injury.
"	D
15951529	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(C(=O)N(C(=S)N1C2=CC(=C(C=C2)C(=O)NC)F)C3=CC(=C(C=C3)C#N)C(F)(F)F)C
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been clearly linked to cases of clinically apparent liver injury with jaundice.
Option B: It has not been convincingly linked to cases of clinically apparent liver injury.
Option C: It has not been linked to cases of clinically apparent liver injury.
Option D: It has not been linked to cases of clinically apparent liver injury with jaundice.
"	D
9913767	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)N(CCCCOCC(=O)NS(=O)(=O)C)C1=CN=C(C(=N1)C2=CC=CC=C2)C3=CC=CC=C3
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been linked convincingly to cases of clinically apparent acute liver injury.
Option B: It has yet to be implicated in cases of clinically apparent acute liver injury.
Option C: It has yet to be linked to instances of clinically apparent acute liver injury.
Option D: It has yet to be convincingly associated with clinically apparent liver injury.
"	B
24776445	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has been linked to rare instances of clinically apparent acute liver injury.
Option B: It has been linked to rare instances of clinically apparent drug induced liver injury.
Option C: It has been associated with rare instances of clinically apparent, acute liver injury.
Option D: It has been linked to rare cases of clinically apparent acute liver injury.
"	D
5360515	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CC1CN2CC[C@]34[C@@H]5C(=O)CC[C@]3([C@H]2CC6=C4C(=C(C=C6)O)O5)O
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury.
Option B: It has a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent acute liver injury.
Option C: It has a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury.
Option D: It has low rates of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury.
"	D
65305	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC1=C[C@]23CCCN2CCC4=CC5=C(C=C4[C@@H]3[C@@H]1O)OCO5
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: Its use is associated with a low rate of serum enzyme elevation, but it has not been linked to cases of clinically apparent liver injury with jaundice.
Option B: It is associated with a low rate of serum enzyme elevations during treatment, but has not been linked to instances of clinically apparent acute liver injury.
Option C: Use of it is associated with a low rate of serum enzyme elevations during therapy but it has not been linked to instances of clinically apparent acute liver injury.
Option D: It is associated with a low rate of serum enzyme elevation during therapy, but it has not been linked to cases of clinically apparent liver injury with jaundice.
"	D
150311	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC(=CC=C1[C@@H]2[C@H](C(=O)N2C3=CC=C(C=C3)F)CC[C@@H](C4=CC=C(C=C4)F)O)O
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of clinically apparent acute liver injury.
Option B: It is associated with a low rate of serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent acute liver injury.
Option C: Therapy is associated with a low rate of serum aminotransferase elevations, but clinically apparent acute liver injury due to it is very rare.
Option D: It is associated with a low rate of serum aminotransferase elevations, and clinically apparent liver injury due to this molecule occurs, but is rare.
"	D
9552079	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC(=CC=C1N/C(=N/C(=NCCCCCCN=C(/N=C(/NC2=CC=C(C=C2)Cl)\\N)N)N)/N)Cl
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: The FDA withdrew its approval for the use of this molecule gluconate topical tincture 0.5% due to a significant number of reports concerning chemical and thermal burns associated with the use of this product.
Option B: The potential of it to cause hepatotoxicity and the greater safety of newer anesthetics has led to a decrease in its use, currently limited to special situations, particularly in children.
Option C: It does not appear to be a significant cause of drug induced liver injury, but can be associated with flares of the underlying hepatitis B either during therapy or upon withdrawal.
Option D: It does not appear to be a significant cause of drug-induced liver injury, but initiation of therapy and sudden withdrawal of therapy can induce a transient exacerbation of the underlying hepatitis B.
"	A
2794	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)N=C1C=C2C(=NC3=CC=CC=C3N2C4=CC=C(C=C4)Cl)C=C1NC5=CC=C(C=C5)Cl
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been linked to serum aminotransferase elevations during therapy nor to instances of clinically apparent liver injury.
Option B: It has not been associated with serum aminotransferase elevations or cases of clinically apparent acute liver injury.
Option C: It has not been associated with serum aminotransferase elevations during therapy or episodes of acute, clinically apparent liver injury.
Option D: It has not been associated with serum aminotransferase elevations during therapy or instances of clinically apparent acute liver injury.
"	D
11434515	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C[N+]2(CCC1[C@H](C2)OC(=O)C(C3=CC=CS3)(C4=CC=CS4)O)CCCOC5=CC=CC=C5
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury.
Option B: It has not been associated with serum enzyme elevations or clinically apparent liver injury.
Option C: It has not been implicated in causing serum enzyme elevations or clinically apparent liver injury.
Option D: It has not been linked to either serum enzyme elevations or to clinically apparent acute liver injury.
"	A
16004692	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It is associated with a low rate of transient serum enzyme elevations during treatment, but has not been implicated in cases of clinically apparent acute liver injury.
Option B: It has been linked to a low rate of serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury.
Option C: It is associated with a low rate of transient serum enzyme elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury with jaundice.
Option D: It has been associated with a low rate of serum enzyme elevations during therapy, but has yet to be implicated in cases of clinically apparent acute liver injury.
"	D
132999	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)C[C@H]3CC4=CC(=C(C=C34)OC)OC
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been associated with serum enzyme elevations during therapy or with clinically apparent liver injury.
Option B: It has not been found to be associated with serum enzyme elevations during therapy or to instances of clinically apparent liver injury.
Option C: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury.
Option D: It has not been associated with serum enzyme elevations during therapy or with published instances of clinically apparent liver injury.
"	C
468595	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC[C@@H]([C@H](C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@H]5C[C@](OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: Therapy with this molecule is associated with a low rate of transient and asymptomatic serum aminotransferase elevations and is a reported, but very rare cause of clinically apparent liver injury.
Option B: It is associated with a low rate of transient and mild serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent acute liver injury.
Option C: It is associated with a low rate of transient and asymptomatic serum aminotransferase elevations during therapy, but has not been linked to instances of clinically apparent acute drug-induced liver injury.
Option D: It is associated with transient, asymptomatic serum aminotransferase elevations and is a suspected but rare cause of clinically apparent acute drug-induced liver injury.
"	D
8606	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C=CCC2C1C(=O)N(C2=O)SC(Cl)(Cl)Cl
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: An increased incidence of tumors was not observed in mice exposed by either gavage or injection.
Option B: The amounts found in typical supplements has not been associated with serum enzyme elevations or with clinically apparent liver injury.
Option C: No significant increase in cancer mortality was observed in workers occupationally exposed to it by inhalation.
Option D: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury.
"	A
44462760	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It is associated with a low rate of serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent acute liver injury.
Option B: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of acute, clinically apparent liver injury.
Option C: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of clinically apparent acute liver injury.
Option D: It is associated with transient elevations in serum aminotransferase during therapy but has not been linked to instances of clinically apparent acute liver injury.
"	D
3356	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CCNC(C1)CNC(=O)C2=C(C=CC(=C2)OCC(F)(F)F)OCC(F)(F)F
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: Long-term therapy is associated with a low rate of serum enzyme elevations and is a very rare cause of clinically apparent acute liver injury.
Option B: Long term therapy is associated with a low rate of serum enzyme elevations and is a rare cause of clinically apparent acute liver injury.
Option C: It is associated with a low rate of transient and asymptomatic serum enzyme elevations and is a rare cause of clinically apparent acute liver injury.
Option D: Long term therapy with this molecule is associated with a low rate of serum enzyme elevations and is a rare cause of clinically apparent acute liver injury.
"	A
5770	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CO[C@H]1[C@@H](C[C@@H]2CN3CCC4=C([C@H]3C[C@@H]2[C@@H]1C(=O)OC)NC5=C4C=CC(=C5)OC)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been shown to cause clinically apparent liver injury.
Option B: It has not been associated with clinically apparent liver injury.
Option C: It has not been linked to episodes of clinically apparent liver injury.
Option D: It has not been associated with instances of clinically apparent liver injury.
"	A
2369	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)NCC(COC1=CC=C(C=C1)CCOCC2CC2)O
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been linked to episodes of clinically apparent liver injury.
Option B: It has not been linked to instances of clinically apparent drug-induced liver injury.
Option C: It has not been linked to instances of clinically apparent drug induced liver injury.
Option D: It has not been associated with instances of clinically apparent liver injury.
"	C
9875401	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1COCC(=O)N1C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CC=C(S4)Cl
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It is associated with a low rate of serum enzyme elevations during treatment and to rare instances of clinically apparent, acute liver injury.
Option B: It has been associated with a low rate of serum enzyme elevations during treatment and with rare instances of clinically apparent cholestatic liver injury.
Option C: It has been associated with a low rate of serum enzyme elevations during treatment and with rare instances of clinically apparent liver injury with jaundice.
Option D: It is associated with a low rate of serum enzyme elevations during treatment and has been implicated in rare instances of clinically apparent, acute liver injury.
"	C
9865528	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)[C@H](CNCCC2=CC=C(C=C2)NC(=O)CC3=CSC(=N3)N)O
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been implicated in causing serum enzyme elevations or clinically apparent liver injury.
Option B: It has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury.
Option C: It has not been associated with serum enzyme elevations or clinically apparent liver injury.
Option D: It has not been linked to either serum enzyme elevations or to clinically apparent acute liver injury.
"	B
60795	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CC(=O)NC2=C1C=CC(=C2)OCCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has been associated with minor serum aminotransferase elevations, but has yet to be linked to cases of clinically apparent acute liver injury.
Option B: Therapy has not been associated consistently with serum aminotransferase elevations and has yet to be linked to cases of clinically apparent acute liver injury.
Option C: It has not been associated with serum aminotransferase elevations or cases of clinically apparent acute liver injury.
Option D: It has not been associated with serum aminotransferase elevations and has not been linked to cases of clinically apparent liver injury.
"	B
2351	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)COCC(CN(CC1=CC=CC=C1)C2=CC=CC=C2)N3CCCC3
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It is associated with a modest rate of minor serum enzyme elevations during therapy, but it has not been linked to cases of clinically apparent liver injury. However, it has been reported to cause reactivation of hepatitis B.
Option B: It does not appear to be a significant cause of drug induced liver injury, but can be associated with flares of the underlying hepatitis B either during therapy or upon withdrawal.
Option C: It does not appear to be a significant cause of drug-induced liver injury, but initiation of therapy and sudden withdrawal of therapy can induce a transient exacerbation of the underlying hepatitis B.
Option D: It is no longer marketed in the United States, as it has been implicated in causing ventricular arrhythmias.
"	D
6917698	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CO[C@H]1CN(CC[C@H]1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It does not appear to be a significant cause of drug induced liver injury, but can be associated with flares of the underlying hepatitis B either during therapy or upon withdrawal.
Option B: It has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias.
Option C: It does not appear to be a significant cause of drug-induced liver injury, but initiation of therapy and sudden withdrawal of therapy can induce a transient exacerbation of the underlying hepatitis B.
Option D: It was the first drug with demonstrated safety and therapeutic efficacy in treating HCV genotype 3 without the need for co-administration of interferon or [DB00811].
"	B
11658860	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1CNCCC2=C1C=C(C=C2)Cl
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been found to be associated with serum enzyme elevations during therapy or to instances of clinically apparent liver injury.
Option B: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury.
Option C: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent liver injury.
Option D: It has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury.
"	A
23725625	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been linked to episodes of clinically apparent liver injury.
Option B: It has not been associated with clinically apparent liver injury.
Option C: It has not been linked to instances of clinically apparent liver injury.
Option D: It has not been associated with instances of clinically apparent liver injury.
"	C
89594	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CCC[C@H]1C2=CN=CC=C2
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been associated with liver test abnormalities or with clinically apparent hepatotoxicity.
Option B: It has not been associated with serum enzyme elevations during therapy or with published instances of clinically apparent liver injury.
Option C: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury.
Option D: It has not been associated with serum enzyme elevations during therapy or with clinically apparent liver injury.
"	A
387447	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: B([C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has been linked to rare cases of clinically apparent acute liver injury.
Option B: It has been associated with rare instances of clinically apparent, acute liver injury.
Option C: It has been linked to rare instances of clinically apparent acute liver injury.
Option D: It has been linked to rare instances of clinically apparent drug induced liver injury.
"	B
60648	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(SC=C1)C(=CCCN2CCC[C@H](C2)C(=O)O)C3=C(C=CS3)C
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: Clinically apparent liver injury from it has not been reported and must be rare if it occurs at all.
Option B: Clinically apparent drug induced liver disease has been reported with its use but is very rare.
Option C: It has not been associated with serum enzyme elevations during therapy or with published instances of clinically apparent liver injury.
Option D: Clinically apparent liver injury from this molecule has been reported, but is very rare.
"	A
5361092	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CC[C@]2([C@H]3CC4=C([C@]2(C1)CCN3CC5CCC5)C=C(C=C4)O)O
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been found to be associated with serum enzyme elevations during therapy or to instances of clinically apparent liver injury.
Option B: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury.
Option C: It has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury.
Option D: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent liver injury.
"	C
5035	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It does not appear to be a significant cause of drug induced liver injury, but can be associated with flares of the underlying hepatitis B either during therapy or upon withdrawal.
Option B: It does not appear to be a significant cause of drug-induced liver injury, but initiation of therapy and sudden withdrawal of therapy can induce a transient exacerbation of the underlying hepatitis B.
Option C: It does not cause endometrial proliferation and is not associated with an increased risk of uterine cancer compared to estrogen and tamoxifen.
Option D: It is associated with a modest rate of minor serum enzyme elevations during therapy, but it has not been linked to cases of clinically apparent liver injury. However, it has been reported to cause reactivation of hepatitis B.
"	C
4158	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC(=O)C(C1CCCCN1)C2=CC=CC=C2
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It is associated with a low rate of serum aminotransferase elevations during therapy and with rare instances of clinically apparent, acute liver injury.
Option B: It is associated with a low rate of serum aminotransferase elevations during therapy and has not been linked to instances of clinically apparent acute liver injury.
Option C: It is associated with a low rate of transient serum aminotransferase elevations during therapy and is a rare cause of clinically apparent acute liver injury.
Option D: It has a low rate of serum aminotransferase elevations during therapy and rare instances of acute, clinically apparent liver injury, generally after its intravenous abuse.
"	D
135400189	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCC1=NC(=C2N1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CC)OCC)C
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been associated with serum aminotransferase elevations and clinically apparent liver injury.
Option B: It has not been associated with serum aminotransferase elevations nor with clinically apparent liver injury.
Option C: It has not been linked to serum aminotransferase elevations during therapy nor to instances of clinically apparent liver injury.
Option D: It has not been associated with serum aminotransferase elevations during therapy or instances of clinically apparent acute liver injury.
"	B
4058	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCOC(=O)C1(CCN(CC1)C)C2=CC=CC=C2
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury.
Option B: It has not been found to be associated with serum enzyme elevations during therapy or to instances of clinically apparent liver injury.
Option C: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent liver injury.
Option D: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury.
"	A
163091	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1C[C@H]2[C@H](C1)C3=C(C=CC(=C3)Cl)OC4=CC=CC=C24
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It is associated with a low rate of transient and mild serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent acute liver injury.
Option B: It is associated with a low rate of transient and asymptomatic serum aminotransferase elevations during therapy, but has not been linked to instances of clinically apparent acute drug-induced liver injury.
Option C: It is associated with a low rate of transient serum aminotransferase elevations and has not been linked to instances of clinically apparent acute liver injury.
Option D: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of acute, clinically apparent liver injury.
"	A
11250029	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=CC(=C1C[C@@H](C(=O)N(CC2=CC(=C(C=C2)OC)C(=O)O)[C@@H](C)C3=NC=C(N3)C4=CC=CC=C4)N)C)C(=O)N
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It is associated with a low rate of serum aminotransferase elevations that appear to be due to isolated instances of sphincter of Oddi spasm and/or pancreatitis that occurs most frequently in persons without a gallbladder.
Option B: Therapy with this molecule has not been associated with serum aminotransferase or alkaline phosphatase elevations, and clinically apparent liver injury from this molecule has not been reported and must be very rare, if it occurs at all.
Option C: It has not been associated with serum aminotransferase or alkaline phosphatase elevations, and clinically apparent liver injury from it has not been reported and must be very rare, if it occurs at all.
Option D: It has not been associated with serum aminotransferase elevations during therapy, and clinically apparent liver injury from this molecule has yet to be reported and must be rare, if it occurs at all.
"	A
216326	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has only rarely been implicated in cases of clinically apparent, acute liver injury.
Option B: It has been implicated with rare instances of clinically apparent, acute liver injury, some of which have been severe.
Option C: It has been implicated in causing rare instances of clinically apparent liver injury which can be severe.
Option D: It has been associated with rare instances of clinically apparent, acute liver injury.
"	C
6450551	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=CC=N4
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has yet to be convincingly associated with clinically apparent liver injury.
Option B: It has not been linked convincingly to cases of clinically apparent acute liver injury.
Option C: It has yet to be linked to instances of clinically apparent acute liver injury.
Option D: It has yet to be implicated in cases of clinically apparent acute liver injury.
"	C
5734	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C2C(=C1)C(=NO2)CS(=O)(=O)N
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: Clinically apparent liver injury from it has not been reported and must be rare if it occurs at all.
Option B: Clinically apparent liver injury from this molecule has been reported, but is very rare.
Option C: Clinically apparent drug induced liver disease has been reported with its use but is very rare.
Option D: It has not been associated with serum enzyme elevations during therapy or with published instances of clinically apparent liver injury.
"	C
10077130	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCOC(=O)N[C@@H]1CC[C@@H]2[C@@H](C1)C[C@@H]3[C@H]([C@H]2/C=C/C4=NC=C(C=C4)C5=CC(=CC=C5)F)[C@H](OC3=O)C
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has not been linked to instances of clinically apparent liver injury.
Option B: It has not been linked to instances of clinically apparent, acute liver injury.
Option C: It has not been associated with instances of clinically apparent liver injury.
Option D: It has not been linked to instances of clinically apparent acute liver injury.
"	D
5479530	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1C(=NC(=O)C(=O)N1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\\OC)/C4=CSC(=N4)N)SC2)C(=O)O
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It can be considered safe in amounts exceeding 2-3 times the minimal recommended daily intake, although hypermethionemia or hyperhomocysteinemia may occur in specific cases of congenital enzyme deficiency, prematurity, or diminished liver function.
Option B: It is associated with a low rate of transient serum enzyme and bilirubin elevations during therapy, but has only rarely been implicated in cases of clinically apparent acute liver injury with jaundice.
Option C: It is associated with a low rate of transient serum enzyme and bilirubin elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury with jaundice.
Option D: It has good activity against multi-drug resistant Enterobacteriaceae, a relatively safe adverse effect profile, and a long half-life which allows for the convenience of daily or twice-daily dosing.
"	D
4493	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(C(=O)N(C(=O)N1)C2=CC(=C(C=C2)[N+](=O)[O-])C(F)(F)F)C
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It has a low rate of serum aminotransferase elevations during therapy and has not been linked to instances of clinically apparent acute liver injury.
Option B: It is associated with a low rate of serum aminotransferase elevations during therapy and with rare instances of clinically apparent, acute liver injury.
Option C: It is associated with a low rate of serum aminotransferase elevations during therapy and has not been linked to instances of clinically apparent acute liver injury.
Option D: It is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of clinically apparent acute liver injury.
"	B
25099191	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC(=CC=C1C2=C(N=CN=C2OCCOC3=NC=C(C=N3)Br)NS(=O)(=O)N)Br
Question about this molecule: What is the right information about this molecule's safety concerns?
Option A: It is associated with a low rate of serum enzyme elevations during treatment and to rare instances of clinically apparent, acute liver injury.
Option B: It is associated with a low rate of serum enzyme elevations during treatment and has been implicated in rare instances of clinically apparent, acute liver injury.
Option C: It has been linked to a low rate of serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury.
Option D: It is under investigation in a clinical trial to show its effect in the treatment of difficult to control high blood pressure and to find out more about its safety.
"	D
4763	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC1(C(=O)NC(=O)NC1=O)C2=CC=CC=C2
Question about this molecule: Which kind of selectivity does this molecule have/exhibit?
Option A: It has selectivity for If channels.
Option B: It has no selectivity.
Option C: It has good selectivity.
Option D: It has greater selectivity.
"	B
15938	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[N+]1=CC=C(C=C1)C2=CC=[N+](C=C2)C.[Cl-].[Cl-]
Question about this molecule: Which kind of selectivity does this molecule have/exhibit?
Option A: It has no selectivity.
Option B: It has good selectivity.
Option C: It has selectivity for If channels.
Option D: It has greater selectivity.
"	A
3348	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)(C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O)C(=O)O
Question about this molecule: Which kind of selectivity does this molecule have/exhibit?
Option A: It has selectivity for the H2 receptor.
Option B: It has selectivity for beta2 receptors.
Option C: It has selectivity for the H1 receptor.
Option D: It has selectivity for estrogen receptor beta (ERβ).
"	C
132999	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)C[C@H]3CC4=CC(=C(C=C34)OC)OC
Question about this molecule: Which kind of selectivity does this molecule have/exhibit?
Option A: It has selectivity for peripheral blood vessels.
Option B: It has selectivity for If channels.
Option C: It has selectivity for insects over mammals.
Option D: It has selectivity for peripheral opioid receptors.
"	B
110635	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CC(=O)N2[C@@H](C1=O)CC3=C([C@H]2C4=CC5=C(C=C4)OCO5)NC6=CC=CC=C36
Question about this molecule: Which kind of selectivity does this molecule have/exhibit?
Option A: It has no selectivity.
Option B: It has greater selectivity for PDE5.
Option C: It has greater selectivity.
Option D: It has good selectivity.
"	B
50516	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)C(C(=O)OC(C#N)C1=CC(=CC=C1)OC2=CC=CC=C2)NC3=C(C=C(C=C3)C(F)(F)F)Cl
Question about this molecule: Which kind of sensitivity does this molecule have/exhibit?
Option A: It can harm sensitive individuals.
Option B: It becomes shock sensitive.
Option C: It is a sensitive high explosive.
Option D: It is especially sensitive to shock and heat.
"	A
16722131	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C(C1(Cl)Cl)(C2=CC=CC=C2)C(=O)OC(C#N)C3=CC(=CC=C3)OC4=CC=CC=C4
Question about this molecule: Which kind of sensitivity does this molecule have/exhibit?
Option A: It can harm sensitive individuals.
Option B: It is a sensitive high explosive.
Option C: It is especially sensitive to shock and heat.
Option D: It becomes shock sensitive.
"	A
83975	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(=CC1C(C1(C)C)C(=O)OCN2C(=O)C3=C(C2=O)CCCC3)C
Question about this molecule: Which kind of sensitivity does this molecule have/exhibit?
Option A: It is a sensitive high explosive.
Option B: It can harm sensitive individuals.
Option C: It is especially sensitive to shock and heat.
Option D: It becomes shock sensitive.
"	B
150311	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC(=CC=C1[C@@H]2[C@H](C(=O)N2C3=CC=C(C=C3)F)CC[C@@H](C4=CC=C(C=C4)F)O)O
Question about this molecule: Which kind of sensitivity does this molecule have/exhibit?
Option A: It can acquire a greenish-brown tint under exposure to sunlight.
Option B: The C=S bond is insensitive to the nature of the substitutent.
Option C: It is insensitive to this molecule treatment.
Option D: Sensitivity to this molecule can be identified with a clinical patch test.
"	C
91768	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)[C@H](C(=O)OC(C#N)C1=CC(=CC=C1)OC2=CC=CC=C2)NC3=C(C=C(C=C3)C(F)(F)F)Cl
Question about this molecule: Which kind of sensitivity does this molecule have/exhibit?
Option A: It is a sensitive high explosive.
Option B: It is especially sensitive to shock and heat.
Option C: It becomes shock sensitive.
Option D: It can harm sensitive individuals.
"	D
5053	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(=CC1C(C1(C)C)C(=O)OCC2=COC(=C2)CC3=CC=CC=C3)C
Question about this molecule: Which kind of sensitivity does this molecule have/exhibit?
Option A: It becomes shock sensitive.
Option B: It can harm sensitive individuals.
Option C: It is a sensitive high explosive.
Option D: It is especially sensitive to shock and heat.
"	B
7594	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)NC(=NC2=CC=CC=C2)N
Question about this molecule: Which kind of sensitivity does this molecule have/exhibit?
Option A: The C=S bond is insensitive to the nature of the substitutent.
Option B: It is insensitive to this molecule treatment.
Option C: It can be identified with a clinical patch test.
Option D: Sensitivity to this molecule can be identified with a clinical patch test.
"	C
3224	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C2C(COS(=O)O1)C3(C(=C(C2(C3(Cl)Cl)Cl)Cl)Cl)Cl
Question about this molecule: What is the smell of this molecule?
Option A: It has a sweet smell.
Option B: It smells like turpentine.
Option C: It has a faint almond-like smell.
Option D: It smells like peppermint.
"	B
4763	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC1(C(=O)NC(=O)NC1=O)C2=CC=CC=C2
Question about this molecule: How is the solubility of this molecule
Option A: It is practically insoluble in water.
Option B: It is readily soluble in water.
Option C: It is soluble in boiling water.
Option D: It is soluble in water.
"	D
119828	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C
Question about this molecule: How is the solubility of this molecule
Option A: It is insoluble in water.
Option B: It is water-soluble.
Option C: It is water insoluble.
Option D: They are water-soluble.
"	B
6327657	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)[Sn](C2=CC=CC=C2)C3=CC=CC=C3.O
Question about this molecule: How is the solubility of this molecule
Option A: It is moderately soluble in organic solvents.
Option B: It is moderately soluble in most organic solvents.
Option C: It is soluble in organic solvents.
Option D: It is soluble in most organic liquids.
"	B
50516	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)C(C(=O)OC(C#N)C1=CC(=CC=C1)OC2=CC=CC=C2)NC3=C(C=C(C=C3)C(F)(F)F)Cl
Question about this molecule: How is the solubility of this molecule
Option A: It is practically insoluble in water.
Option B: It is insoluble in water.
Option C: It is soluble in water.
Option D: It is readily soluble in water.
"	B
6918485	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@H](C1=NC(=CS1)C2=CC=C(C=C2)C#N)[C@](CN3C=NC=N3)(C4=C(C=CC(=C4)F)F)O
Question about this molecule: How is the solubility of this molecule
Option A: It displays low water solubility.
Option B: It has low aqueous solubility.
Option C: It has low water solubility.
Option D: It has low solubility.
"	A
11463	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CCC(=C(C)C)CC1
Question about this molecule: How is the solubility of this molecule
Option A: It is practically insoluble in water.
Option B: It is insoluble in water.
Option C: It is soluble in water.
Option D: It is readily soluble in water.
"	B
91754	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)(C)C1=CC=C(C=C1)CSC2=C(C(=O)N(N=C2)C(C)(C)C)Cl
Question about this molecule: How is the solubility of this molecule
Option A: It has a low solubility profile.
Option B: It has a low aqueous solubility.
Option C: It has low aqueous solubility.
Option D: It has low aqueous solubility and is not expected to leach to groundwater.
"	D
17038	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C=CCC2C1C(=O)N(C2=O)SC(C(Cl)Cl)(Cl)Cl
Question about this molecule: How is the solubility of this molecule
Option A: It is practically insoluble in water.
Option B: It is soluble in water.
Option C: It is readily soluble in water.
Option D: It is insoluble in water.
"	A
30231	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=CC(=C(C(=C3)O)C(=O)CCC4=CC(=C(C=C4)OC)O)O)CO)O)O)O)O)O
Question about this molecule: How is the solubility of this molecule
Option A: It is soluble in water.
Option B: It is practically insoluble in water.
Option C: It is readily soluble in water.
Option D: It is insoluble in water.
"	D
6918606	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@H](C1=NC(=CS1)C2=CC=C(C=C2)C#N)[C@](CN3C=[N+](C=N3)C(C)OC(=O)N(C)C4=C(C=CC=N4)COC(=O)CNC)(C5=C(C=CC(=C5)F)F)O
Question about this molecule: How is the solubility of this molecule
Option A: It is very soluble in pure water, but will become soluble if the aqueous solution is acidic due to formation of ammonium salts, as usual for organic amines.
Option B: It dissolves readily in water to form flammable corrosive solutions.
Option C: It is slightly soluble in water and soluble in organic solvents.
Option D: It has low solubility in water on its own, but the isovuconazonium formulation has high solubility in water.
"	D
4030	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CC=C3
Question about this molecule: How is the solubility of this molecule
Option A: It is relatively water insoluble.
Option B: It is water insoluble.
Option C: It is practically insoluble in water.
Option D: Practically water insoluble
"	D
36324	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=C(C=C1)N=CN(C)C=NC2=C(C=C(C=C2)C)C)C
Question about this molecule: How is the solubility of this molecule
Option A: It is insoluble in water.
Option B: It is practically insoluble in water.
Option C: It is soluble in water.
Option D: It is readily soluble in water.
"	A
2794	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)N=C1C=C2C(=NC3=CC=CC=C3N2C4=CC=C(C=C4)Cl)C=C1NC5=CC=C(C=C5)Cl
Question about this molecule: How is the solubility of this molecule
Option A: It is slightly soluble in water.
Option B: It is fat soluble.
Option C: It is water soluble.
Option D: It is slightly water soluble.
"	B
8606	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C=CCC2C1C(=O)N(C2=O)SC(Cl)(Cl)Cl
Question about this molecule: How is the solubility of this molecule
Option A: It is soluble in water, alcohols, and ether.
Option B: It is slightly soluble in water and soluble in organic solvents.
Option C: It is a water-soluble, white crystalline solid compound consisting of hydrogen peroxide and urea.
Option D: It is a white solid dissolved in a liquid carrier.
"	D
3224	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C2C(COS(=O)O1)C3(C(=C(C2(C3(Cl)Cl)Cl)Cl)Cl)Cl
Question about this molecule: How is the solubility of this molecule
Option A: It is insoluble in water.
Option B: Nearly insoluble in water.
Option C: It is readily soluble in water.
Option D: It is practically insoluble in water.
"	B
5281875	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(CN=C(NC1)NN=C(/C=C/C2=CC=C(C=C2)C(F)(F)F)/C=C/C3=CC=C(C=C3)C(F)(F)F)C
Question about this molecule: How is the solubility of this molecule
Option A: It is insoluble in water.
Option B: It is practically insoluble in water.
Option C: It is soluble in water.
Option D: It is readily soluble in water.
"	A
3476	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC1=C(CN(C1=O)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)C)C
Question about this molecule: How is the solubility of this molecule
Option A: It is water soluble.
Option B: It is fat soluble.
Option C: It is slightly soluble in water.
Option D: It is slightly water soluble.
"	B
5053	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(=CC1C(C1(C)C)C(=O)OCC2=COC(=C2)CC3=CC=CC=C3)C
Question about this molecule: How is the solubility of this molecule
Option A: It is practically insoluble in water.
Option B: It is insoluble in water.
Option C: It is readily soluble in water.
Option D: It is soluble in water.
"	B
135533054	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C2C=C(C(=CC2=C1)C(=O)N/N=C/C3=CC(=C(C=C3)O)O)O
Question about this molecule: Which kind of specificity does this molecule have/exhibit?
Option A: It is specific for the gate-keeper T790M mutations which increases ATP binding activity to EGFR and result in poor prognosis for late-stage disease.
Option B: It is a cell-permeable, reversible noncompetitive inhibitor of the GTPase activity of dynamin 1 and 2 and Drp1 (mitochondrial), while exhibiting no significant effect against two other small GTPases, MxA and Cdc42.
Option C: It reduces pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected.
Option D: It competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV.
"	B
16133751	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)[C@@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N3CCC[C@H]3C(=O)O)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC7=CC=CC=C7)NC(=O)[C@H](CC8=CN=CN8)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CC9=CC=C(C=C9)O)NC(=O)[C@H](CO)N
Question about this molecule: Which kind of specificity does this molecule have/exhibit?
Option A: It reduces pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected.
Option B: It displays an intermediate specificity to target both the cardiac and vascular smooth muscle.
Option C: It contains the biological activity that stimulates production of corticosteroids in the adrenal cortex.
Option D: It has higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart.
"	C
4747	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CN(CCC1O)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C#N
Question about this molecule: Which kind of specificity does this molecule have/exhibit?
Option A: It reduces pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected.
Option B: It competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV.
Option C: It is specific for the gate-keeper T790M mutations which increases ATP binding activity to EGFR and result in poor prognosis for late-stage disease.
Option D: It has higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart.
"	A
6327657	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)[Sn](C2=CC=CC=C2)C3=CC=CC=C3.O
Question about this molecule: How is the stability of this molecule
Option A: It degrades rapidly and readily evaporates into air.
Option B: Stable at room temperature.
Option C: Stable in air.
Option D: The solid is stable at room temperature.
"	B
50516	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)C(C(=O)OC(C#N)C1=CC(=CC=C1)OC2=CC=CC=C2)NC3=C(C=C(C=C3)C(F)(F)F)Cl
Question about this molecule: How is the stability of this molecule
Option A: They are chemically stable over a wide range of temperature and pH.
Option B: It is usually broken apart by sunlight and the atmosphere in one or two days.
Option C: They are usually broken apart by sunlight and the atmosphere in one or two days.
Option D: It degrades rapidly and readily evaporates into air.
"	B
16722131	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C(C1(Cl)Cl)(C2=CC=CC=C2)C(=O)OC(C#N)C3=CC(=CC=C3)OC4=CC=CC=C4
Question about this molecule: How is the stability of this molecule
Option A: They are chemically stable over a wide range of temperature and pH.
Option B: It is usually broken apart by sunlight and the atmosphere in one or two days.
Option C: They are usually broken apart by sunlight and the atmosphere in one or two days.
Option D: It degrades rapidly and readily evaporates into air.
"	B
213031	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(CCCCC1)C(=O)NC2=C(C(=C(C=C2)O)Cl)Cl
Question about this molecule: How is the stability of this molecule
Option A: It is usually broken apart by sunlight and the atmosphere in one or two days.
Option B: It is protected from being washed off by rainfall or irrigation.
Option C: They are usually broken apart by sunlight and the atmosphere in one or two days.
Option D: They are chemically stable over a wide range of temperature and pH.
"	B
149096	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
Question about this molecule: How is the stability of this molecule
Option A: It is unstable.
Option B: It is unstable in the pure form.
Option C: It remains stereochemically stable following administration.
Option D: They lack unstable functionality.
"	C
83975	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(=CC1C(C1(C)C)C(=O)OCN2C(=O)C3=C(C2=O)CCCC3)C
Question about this molecule: How is the stability of this molecule
Option A: They are chemically stable over a wide range of temperature and pH.
Option B: It degrades rapidly and readily evaporates into air.
Option C: They are usually broken apart by sunlight and the atmosphere in one or two days.
Option D: It is usually broken apart by sunlight and the atmosphere in one or two days.
"	C
91768	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)[C@H](C(=O)OC(C#N)C1=CC(=CC=C1)OC2=CC=CC=C2)NC3=C(C=C(C=C3)C(F)(F)F)Cl
Question about this molecule: How is the stability of this molecule
Option A: It is usually broken apart by sunlight and the atmosphere in one or two days.
Option B: They are chemically stable over a wide range of temperature and pH.
Option C: It degrades rapidly and readily evaporates into air.
Option D: They are usually broken apart by sunlight and the atmosphere in one or two days.
"	D
6438357	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)C(=C)N(C(=O)CC[C@@H](NC1=O)C(=O)O)C)C)CCCN=C(N)N)C(=O)O)C)CCCN=C(N)N)/C=C/C(=C/[C@H](C)[C@H](CC2=CC=CC=C2)OC)/C
Question about this molecule: How is the stability of this molecule
Option A: They are chemically stable over a wide range of temperature and pH.
Option B: It is stable at acidic pH but undergoes spontaneous nonenzymatic hydrolysis at neutral or slightly basic pH.
Option C: It is chemically stable over a wide range of temperature and pH, possibly as a result of its cyclic structure.
Option D: Microcystins are chemically stable over a wide range of temperature and pH.
"	D
445434	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)C(=C)N(C(=O)CC[C@@H](NC1=O)C(=O)O)C)C)CC(C)C)C(=O)O)C)CCCN=C(N)N)/C=C/C(=C/[C@H](C)[C@H](CC2=CC=CC=C2)OC)/C
Question about this molecule: How is the stability of this molecule
Option A: Microcystins are chemically stable over a wide range of temperature and pH.
Option B: It is chemically stable over a wide range of temperature and pH, possibly as a result of its cyclic structure.
Option C: They are chemically stable over a wide range of temperature and pH.
Option D: It is stable at acidic pH but undergoes spontaneous nonenzymatic hydrolysis at neutral or slightly basic pH.
"	C
4763	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC1(C(=O)NC(=O)NC1=O)C2=CC=CC=C2
Question about this molecule: Which kind of taste does this molecule have/exhibit?
Option A: It has a slightly bitter taste.
Option B: It has a slightly acid taste.
Option C: It has a slightly bitter burning taste.
Option D: It has a slightly sweet taste.
"	A
5284627	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(O[C@@H]2CO[C@@]3([C@H]([C@@H]2O1)OC(O3)(C)C)COS(=O)(=O)N)C
Question about this molecule: Which kind of taste does this molecule have/exhibit?
Option A: It has a lightly bitter taste.
Option B: It has a bad taste.
Option C: It has a bitter taste.
Option D: It has a sweet taste.
"	B
5344	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(ON=C1C)NS(=O)(=O)C2=CC=C(C=C2)N
Question about this molecule: Which kind of taste does this molecule have/exhibit?
Option A: It has a slightly acid taste.
Option B: It has a slightly sweet taste.
Option C: It has a slightly bitter taste.
Option D: It has a slightly bitter burning taste.
"	C
1775	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)C2(C(=O)NC(=O)N2)C3=CC=CC=C3
Question about this molecule: Which kind of taste does this molecule have/exhibit?
Option A: It has a distinct taste.
Option B: It is tasteless.
Option C: It has a spicy taste.
Option D: It has a sweet taste.
"	B
5770	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CO[C@H]1[C@@H](C[C@@H]2CN3CCC4=C([C@H]3C[C@@H]2[C@@H]1C(=O)OC)NC5=C4C=CC(=C5)OC)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC
Question about this molecule: Which kind of taste does this molecule have/exhibit?
Option A: It has a bitter taste.
Option B: It has a slightly bitter taste.
Option C: It has a lightly bitter taste.
Option D: It has a very bitter taste.
"	A
1986	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(=O)NC1=NN=C(S1)S(=O)(=O)N
Question about this molecule: Which kind of taste does this molecule have/exhibit?
Option A: It has no smell or taste.
Option B: It has no taste.
Option C: It has neither odor nor taste.
Option D: It has no odor or taste.
"	D
7594	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)NC(=NC2=CC=CC=C2)N
Question about this molecule: Which kind of taste does this molecule have/exhibit?
Option A: It has a slight sweet taste.
Option B: It has a bitter taste and slight odor.
Option C: It has a slight odor and taste.
Option D: It has a slightly bitter taste.
"	B
37542	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=NC(=NN1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(=O)N
Question about this molecule: What is the right information about this molecule's therapeutic effects?
Option A: It exerts its therapeutic effect by inhibiting autophosphorylation of ALK, ALK-mediated phosphorylation of the downstream signaling protein STAT3, and proliferation of ALK-dependent cancer cells.
Option B: It improves CF symptoms and underlying disease pathology by aiding the conformational stability of F508del-mutated CFTR proteins, preventing misfolding and resulting in increased processing and trafficking of mature protein to the cell surface.
Option C: Addition of weight-based ribavirin to Technivie therapy increased sustained virologic response after 12 weeks of daily therapy (SVR12) from 90% to 97% in patients with HCV genotype 1a and 90.9% to 100% in HCV genotype 4 patients.
Option D: It has a variety of therapeutic applications, including pupil dilation and the treatment of anticholinergic poisoning and symptomatic bradycardia in the absence of reversible causes.
"	C
5311309	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)C1CCC(CC1)C(=O)N[C@H](CC2=CC=CC=C2)C(=O)O
Question about this molecule: What is the right information about this molecule's therapeutic effects?
Option A: It has the propensity to completely or partially reverse the abnormal metabolism of damaged brain cells after injury.
Option B: Approximately one month of therapy is required before a decrease in fasting blood glucose is seen.
Option C: It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected.
Option D: It has a variety of therapeutic applications, including pupil dilation and the treatment of anticholinergic poisoning and symptomatic bradycardia in the absence of reversible causes.
"	B
16678941	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O
Question about this molecule: What is the right information about this molecule's therapeutic effects?
Option A: It improves CF symptoms and underlying disease pathology by aiding the conformational stability of F508del-mutated CFTR proteins, preventing misfolding and resulting in increased processing and trafficking of mature protein to the cell surface.
Option B: Addition of weight-based ribavirin to Technivie therapy increased sustained virologic response after 12 weeks of daily therapy (SVR12) from 90% to 97% in patients with HCV genotype 1a and 90.9% to 100% in HCV genotype 4 patients.
Option C: It exerts its therapeutic effect by inhibiting autophosphorylation of ALK, ALK-mediated phosphorylation of the downstream signaling protein STAT3, and proliferation of ALK-dependent cancer cells.
Option D: It has a variety of therapeutic applications, including pupil dilation and the treatment of anticholinergic poisoning and symptomatic bradycardia in the absence of reversible causes.
"	A
4747	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CN(CCC1O)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C#N
Question about this molecule: What is the right information about this molecule's therapeutic effects?
Option A: It improves CF symptoms and underlying disease pathology by aiding the conformational stability of F508del-mutated CFTR proteins, preventing misfolding and resulting in increased processing and trafficking of mature protein to the cell surface.
Option B: It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected.
Option C: It has a variety of therapeutic applications, including pupil dilation and the treatment of anticholinergic poisoning and symptomatic bradycardia in the absence of reversible causes.
Option D: It exerts its therapeutic effect by inhibiting autophosphorylation of ALK, ALK-mediated phosphorylation of the downstream signaling protein STAT3, and proliferation of ALK-dependent cancer cells.
"	B
174174	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)C(CO)C3=CC=CC=C3
Question about this molecule: What is the right information about this molecule's therapeutic effects?
Option A: It has a variety of therapeutic applications, including pupil dilation and the treatment of anticholinergic poisoning and symptomatic bradycardia in the absence of reversible causes.
Option B: It exerts its therapeutic effect by inhibiting autophosphorylation of ALK, ALK-mediated phosphorylation of the downstream signaling protein STAT3, and proliferation of ALK-dependent cancer cells.
Option C: It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected.
Option D: It improves CF symptoms and underlying disease pathology by aiding the conformational stability of F508del-mutated CFTR proteins, preventing misfolding and resulting in increased processing and trafficking of mature protein to the cell surface.
"	A
57379345	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=C(C=C1C2CCNCC2)OC(C)C)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)C(C)C)Cl
Question about this molecule: What is the right information about this molecule's therapeutic effects?
Option A: Addition of weight-based ribavirin to Technivie therapy increased sustained virologic response after 12 weeks of daily therapy (SVR12) from 90% to 97% in patients with HCV genotype 1a and 90.9% to 100% in HCV genotype 4 patients.
Option B: It improves CF symptoms and underlying disease pathology by aiding the conformational stability of F508del-mutated CFTR proteins, preventing misfolding and resulting in increased processing and trafficking of mature protein to the cell surface.
Option C: It has a variety of therapeutic applications, including pupil dilation and the treatment of anticholinergic poisoning and symptomatic bradycardia in the absence of reversible causes.
Option D: It exerts its therapeutic effect by inhibiting autophosphorylation of ALK, ALK-mediated phosphorylation of the downstream signaling protein STAT3, and proliferation of ALK-dependent cancer cells.
"	D
656665	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)C3=CNC4=CC=CC=C43
Question about this molecule: How is the tolerability of this molecule
Option A: It was generally well tolerated.
Option B: It is generally well tolerated.
Option C: It is well tolerated in most patients.
Option D: It appears to be well tolerated.
"	D
49831411	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCCCCCCCCCC(=O)OCN1C(=O)CCC2=C1C=C(C=C2)OCCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl
Question about this molecule: How is the tolerability of this molecule
Option A: The establishment of tolerability is required prior to dosing in treatment-naïve patients.
Option B: It has a side-effect profile superior to that of other antihypertensive drugs.
Option C: Both cream and suppository forms have demonstrated high levels of safety, efficacy, and tolerability.
Option D: It is generally well tolerated and a useful alternative to non-selective β-blocker drugs.
"	A
135409400	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C2=C(C=CC(=C2Cl)Cl)N=C3N1CC(=O)N3
Question about this molecule: How is the tolerability of this molecule
Option A: It is generally well tolerated but can rarely cause clinically apparent and serious acute liver injury.
Option B: It has been better tolerated than tri- or heterocyclic antidepressants.
Option C: It may be better tolerated than other thrombocythemia treatments.
Option D: It seems to be well tolerated, but patients with renal impairment may develop neurotoxicity.
"	C
5479537	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[N+]1(CCCC1)CC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\\OC)/C4=CSC(=N4)N)SC2)C(=O)[O-]
Question about this molecule: How is the tolerability of this molecule
Option A: It has a side-effect profile superior to that of other antihypertensive drugs.
Option B: It is generally well tolerated but can rarely cause clinically apparent and serious acute liver injury.
Option C: It has been better tolerated than tri- or heterocyclic antidepressants.
Option D: It seems to be well tolerated, but patients with renal impairment may develop neurotoxicity.
"	D
5311221	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)OC(=O)CCC/C=C\\C[C@H]1[C@H](C[C@H]([C@@H]1CC[C@H](CCC2=CC=CC=C2)O)O)O
Question about this molecule: How is the tolerability of this molecule
Option A: It has been found to be well-tolerated.
Option B: It appears to be well tolerated.
Option C: It was generally well tolerated.
Option D: It is generally well tolerated.
"	A
183528	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC2=C(C=C1O)NC=C2C(=O)C3=NC=C(N3)C4=CNC5=C4C=CC(=C5)Br
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is highly toxic to aquatic life, particularly fish.
Option B: It is highly toxic to mammals and insects.
Option C: It is extremely toxic to birds.
Option D: It is toxic to fish.
"	D
2236	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC1=CC=CC2=C3C(=C(C=C21)[N+](=O)[O-])C(=CC4=C3OCO4)C(=O)O
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It generally does not cause nephrotoxicity or fibrosis.
Option B: It is both carcinogenic and nephrotoxic.
Option C: It exhibits nephrotoxicity and ototoxicity.
Option D: It has low inhalation hazard and no apparent skin manifestations or other toxicity in humans.
"	B
21775039	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C=C/C=C/1\\C2C(=C(C1=O)O)C=CCO2
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: Acute exposure to high levels of it may cause severe dermatitis, eye irritation and tearing, asthma, gastritis, renal failure, vertigo, tremors, convulsions, and coma in humans.
Option B: It can lead to acute psychosis, aggressive and violent behaviors, and overdoses can cause status epilepticus, hyperthermia, rhabdomyolysis and subsequent renal, respiratory and hepatic failure.
Option C: It exhibits toxicity against HCT116 cells (human colorectal cancer cells) by triggering apoptotic cell death.
Option D: It can cause minor transient serum enzyme elevations and has been linked to cases of acute liver injury including cholestatic hepatitis and acute veno-occlusive disease.
"	C
19972	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)OC
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It exhibits high toxicity when ingested in certain quantities.
Option B: It exhibits a high level of toxicity.
Option C: It exhibits high toxicity by inhalation and ingestion.
Option D: It exhibits low acute toxicity to various organisms.
"	B
21775040	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C=C/C=C\\1/C2C(=C(C1=O)O)C=CCO2
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It can cause minor transient serum enzyme elevations and has been linked to cases of acute liver injury including cholestatic hepatitis and acute veno-occlusive disease.
Option B: It has been linked to cases of acute liver injury, including acute cholestatic hepatitis and veno-occlusive disease.
Option C: It exhibits toxicity against HCT116 cells (human colorectal cancer cells) by triggering apoptotic cell death.
Option D: Long-term therapy with this molecule is associated with the development of fatty liver, steatohepatitis, cirrhosis, and rare instances of clinically apparent acute liver injury.
"	C
10238657	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(C2=C(N1S(=O)(=O)C3=NN(C=N3)S(=O)(=O)N(C)C)C=C(C=C2)F)Br
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is considered to be a reproduction toxicant and is moderately toxic to birds and honey bees.
Option B: It is moderately toxic to birds, most aquatic organisms, honeybees and earthworms.
Option C: It is moderately toxic to humans, mammals, birds and most aquatic organisms.
Option D: It is moderately toxic to mammals, birds, earthworms and most aquatic organisms.
"	A
24853674	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCCCCCCCCCCC[C@@H]1C[C@H](C[C@]2(O1)CC[C@@]3(O2)C=CC(=O)C[C@@H]3O)O
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It has low toxicity to mammals.
Option B: It exhibits toxicity against some cancer cell lines.
Option C: It has low acute toxicity to mammals.
Option D: It exhibits low acute toxicity to various organisms.
"	B
11578610	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=CC(=C1NC(=O)C2=CC(=NN2C3=C(C=CC=N3)Cl)Br)C(=O)NC)C#N
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is extremely toxic to birds.
Option B: It is highly toxic to mammals and insects.
Option C: It is highly toxic to aquatic life, particularly fish.
Option D: It is highly toxic to honeybees.
"	D
3292	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCN1C(=O)C(NC1=O)C2=CC=CC=C2
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is less toxic than phenytoin.
Option B: It is a uremic toxin and has been involved in the progression of renal failure.
Option C: It has toxic properties and suggests that it is an uremic toxin.
Option D: It is considered to be a uremic toxin and is poorly cleared with dialysis.
"	A
28292	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCOP(=O)(SC1=CC=CC=C1)SC2=CC=CC=C2
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is moderately toxic to mammals, birds, earthworms and most aquatic organisms.
Option B: It is moderately toxic to humans, mammals, birds and most aquatic organisms.
Option C: It is moderately toxic to mammals and fish but poses more of a risk to aquatic invertebrates.
Option D: It is moderately toxic to mammals, birds, fish, and aquatic invertebrates.
"	C
3002977	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=NN=C(N1C2C[C@H]3CC[C@@H](C2)N3CC[C@@H](C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F)C(C)C
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is associated with serum aminotransferase elevations and rare instances of clinically apparent acute liver injury.
Option B: It has been associated with elevations in serum aminotransferase levels and acute, clinically apparent liver injury.
Option C: It is associated with transient elevations in serum aminotransferase levels during treatment and rare instances of clinically apparent acute liver injury.
Option D: It is associated with frequent elevations in serum aminotransferase levels and with rare instances of clinically apparent acute liver injury.
"	B
4763	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC1(C(=O)NC(=O)NC1=O)C2=CC=CC=C2
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It has been linked to rare cases of idiosyncratic, clinically apparent liver injury.
Option B: It has been linked to rare instances of idiosyncratic, clinically apparent acute liver injury.
Option C: It has been linked to rare instances of clinically apparent, idiosyncratic liver injury.
Option D: It has been linked to rare instances of idiosyncratic liver injury that can be severe and even fatal.
"	D
9924495	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)N2C=C(C=C(C2=O)C3=CC=CC=C3C#N)C4=CC=CC=N4
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It has been linked to rare instances of clinically apparent drug induced liver disease.
Option B: It has been linked to rare instances of clinically apparent acute drug induced liver injury.
Option C: It has serious or life-threatening behavioral and psychiatric reactions.
Option D: It has not been linked to rare instances of mild, self-limited, clinically apparent liver injury.
"	C
5281034	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C)O)CC[C@@H]4[C@@]3(C/C(=C/O)/C(=O)C4)C
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It has been linked to rare instances of clinically apparent acute liver injury.
Option B: It is linked to rare instances of clinically apparent acute liver injury.
Option C: It can lead to clinically apparent acute liver injury.
Option D: It can lead to cardiovascular events.
"	D
5284627	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1(O[C@@H]2CO[C@@]3([C@H]([C@@H]2O1)OC(O3)(C)C)COS(=O)(=O)N)C
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It can cause clinically apparent hepatic injury.
Option B: It has been rarely associated with hepatic injury.
Option C: It can rarely result in clinically apparent, cholestatic liver injury.
Option D: It has been associated with occasional cases of severe and distinctive acute hepatic failure.
"	B
2170	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is associated with a moderate rate of serum aminotransferase elevations during therapy and rare instances of clinically apparent acute liver injury.
Option B: It has a low rate of minor serum aminotransferase elevations during treatment and very rare instances of clinically apparent acute liver injury.
Option C: It is associated with a low rate of transient serum aminotransferase elevations and rare instances of clinically apparent acute liver injury.
Option D: It is associated with a low rate of transient serum aminotransferase elevations and with rare instances of clinically apparent acute liver injury.
"	B
11450633	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCC[C@H](C3)N
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It has been reported to cause liver injury, but the characteristics and details of the injury have not been defined in the published literature.
Option B: It has a modest rate of serum enzyme elevations during therapy, but has not been convincingly linked to instances of clinically apparent acute liver injury.
Option C: It has been reported to cause serum enzyme elevations during therapy but has not been implicated in instances of clinically apparent acute liver injury.
Option D: It is associated with rare occurrence of transient serum enzyme elevations, but has not been implicated in cases of clinically apparent liver injury.
"	A
50516	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)C(C(=O)OC(C#N)C1=CC(=CC=C1)OC2=CC=CC=C2)NC3=C(C=C(C=C3)C(F)(F)F)Cl
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It can harm sensitive individuals, but is generally harmless to human beings in the concentrations used in such products.
Option B: It is generally harmless but can harm sensitive individuals.
Option C: It can harm sensitive individuals but is generally harmless to human beings in the concentrations used in such products.
Option D: It is generally harmless to human beings but can harm sensitive individuals.
"	C
71482	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COP(=O)(OC)SCN1C2=C(C=C(C=N2)Cl)OC1=O
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It generally does not cause nephrotoxicity or fibrosis.
Option B: It exhibits moderate acute oral toxicity to mammals but has high acute oral toxicity to birds.
Option C: It can cause neurotoxicity in humans, including numbness, cyanosis, hyperesthesia, and muscle spasms.
Option D: It has low inhalation hazard and no apparent skin manifestations or other toxicity in humans.
"	B
4583	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It has been linked to acute hepatocellular injury.
Option B: It has been linked to rare instances of acute cholestatic liver injury.
Option C: It has been linked to rare instances of clinically apparent acute cholestatic liver injury.
Option D: It has been linked to rare instances of acute hepatocellular injury.
"	D
6918485	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@H](C1=NC(=CS1)C2=CC=C(C=C2)C#N)[C@](CN3C=NC=N3)(C4=C(C=CC(=C4)F)F)O
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It has low inhalation hazard and no apparent skin manifestations or other toxicity in humans.
Option B: It generally does not cause nephrotoxicity or fibrosis.
Option C: It does not require cyclodextrin for facilitating drug solubility, which avoids the potential nephrotoxicity associated with cyclodextrin.
Option D: It avoids the use of a cyclodextrin vehicle for solubilization, eliminating concerns of nephrotoxicity associated with cyclodextrin.
"	C
135398737	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is associated with frequent elevations in serum aminotransferase levels and with rare instances of clinically apparent acute liver injury.
Option B: It can cause transient and usually asymptomatic elevations in serum aminotransferase levels and rare instances of clinically apparent acute liver injury.
Option C: It has transient elevations in serum aminotransferase levels during therapy and rare instances of clinically apparent acute liver injury.
Option D: It is associated with serum aminotransferase elevations and rare instances of clinically apparent acute liver injury.
"	D
1775	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)C2(C(=O)NC(=O)N2)C3=CC=CC=C3
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It can cause acute idiosyncratic drug induced liver disease.
Option B: It has been linked to rare instances of idiosyncratic, clinically apparent acute liver injury.
Option C: It has been linked to rare instances of idiosyncratic drug-induced liver disease.
Option D: It has been linked to rare instances of idiosyncratic drug induced liver disease.
"	A
3749	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It has a low rate of transient serum aminotransferase elevations and rare instances of acute liver injury.
Option B: It is associated with a low rate of transient serum aminotransferase elevations and rare instances of acute liver injury.
Option C: It is associated with a low rate of transient serum aminotransferase elevations and with rare instances of clinically apparent acute liver injury.
Option D: It has a low rate of transient serum aminotransferase elevations and has been linked to rare instances of acute liver injury.
"	A
82146	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC2=C(C=C1C(=C)C3=CC=C(C=C3)C(=O)O)C(CCC2(C)C)(C)C
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is associated with a high rate of serum enzyme elevations and rare instances of clinically apparent acute liver injury.
Option B: It is associated with a minimal rate of serum enzyme elevations during therapy and is a rare cause of clinically apparent liver injury.
Option C: It is associated with a variable rate of serum enzyme elevations during therapy and rare instances of severe liver injury.
Option D: It can cause serum enzyme elevations during therapy and rare instances of clinically apparent acute liver injury.
"	A
214348	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C(=C1)C2=NN(C(=N2)C3=CC=CC=C3O)C4=CC=C(C=C4)C(=O)O)O
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is associated with a low rate of transient serum aminotransferase elevations during therapy and rare cases of clinically apparent acute liver injury.
Option B: It is associated with a moderate rate of serum aminotransferase elevations during therapy and rare instances of clinically apparent acute liver injury.
Option C: It is associated with a low rate of transient serum aminotransferase elevations and with rare instances of clinically apparent acute liver injury.
Option D: It has been linked to a low rate of transient serum aminotransferase elevations during therapy and to rare instances of clinically apparent liver injury.
"	D
6918296	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)NC4=C(C=CC(=C4)C(F)(F)F)C(F)(F)F)CC[C@@H]5[C@@]3(C=CC(=O)N5)C
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is associated with a low rate of transient serum aminotransferase elevations but has yet to be linked to instances of acute liver injury.
Option B: It has a low rate of transient serum aminotransferase elevations and has not been clearly linked to clinically apparent acute liver injury.
Option C: It has a low rate of transient serum aminotransferase elevations during therapy, but has not been linked to instances of clinically apparent acute liver injury.
Option D: It is associated with a low rate of transient serum aminotransferase elevations, but has yet to be linked to instances of clinically apparent acute liver injury.
"	D
4829	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It can be associated with rare instances of clinically apparent acute liver injury.
Option B: It is linked to rare instances of clinically apparent acute liver injury.
Option C: It has been linked to rare instances of acute liver injury.
Option D: It has been linked to rare instances of clinically apparent acute liver injury.
"	C
15938	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[N+]1=CC=C(C=C1)C2=CC=[N+](C=C2)C.[Cl-].[Cl-]
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is extremely toxic and among the most poisonous chemicals commonly used for pest control.
Option B: It can cause Paraquat poisoning, leading to suicides.
Option C: It has caused an excess number of poisoning related deaths.
Option D: It denatures and precipitates cellular proteins and thus may rapidly cause poisoning.
"	B
107713	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(=CCO[C@H]1C2=C3[C@H](CC(OO[C@@H](N3C4=C2C=CC(=C4)OC)C=C(C)C)(C)C)N5[C@@]1(C(=O)N6CCC[C@H]6C5=O)O)C
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It has neurotoxic effects and potential serious neuropsychiatric effects.
Option B: It is a potent neurotropic and tremorgenic mycotoxin.
Option C: It is neurotoxic and can induce spastic myelopathy in rabbits.
Option D: It may cause neurotoxicity, especially in patients with renal impairment.
"	B
9444	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=NC(=NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It can cause covalent binding with DNA methyltransferases, preventing DNA synthesis and subsequent cytotoxicity.
Option B: It can cause sensitization and asthma in humans when inhaled at high concentrations.
Option C: It causes central nervous system effects when inhaled at high concentrations.
Option D: It can cause narcotic effects when inhaled at high concentrations.
"	A
91754	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)(C)C1=CC=C(C=C1)CSC2=C(C(=O)N(N=C2)C(C)(C)C)Cl
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is moderately toxic to mammals and does not bioaccumulate.
Option B: It is moderately toxic to mammals, birds, earthworms and most aquatic organisms.
Option C: It is moderately toxic to mammals and fish but poses more of a risk to aquatic invertebrates.
Option D: It is moderately toxic to humans, mammals, birds and most aquatic organisms.
"	A
24826799	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It has been linked to rare instances of clinically apparent acute liver injury.
Option B: It is linked to rare instances of clinically apparent acute liver injury.
Option C: It has rare instances of clinically apparent acute liver injury.
Option D: It can be associated with rare instances of clinically apparent acute liver injury.
"	C
17038	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C=CCC2C1C(=O)N(C2=O)SC(C(Cl)Cl)(Cl)Cl
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It exhibits high toxicity by inhalation and ingestion.
Option B: It exhibits low acute toxicity to various organisms.
Option C: It exhibits toxicity by inhalation, skin absorption, and ingestion.
Option D: Acute oral toxicity in humans is low.
"	D
6433272	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1/C=C/C=C/CC/C=C/C=C/C=C/C=C/C(CC2C(C(C[C@](O2)(CC(C(CCC(CC(CC(CC(=O)O[C@H]([C@@H]([C@@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)O[C@@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)O)N)O
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It has low acute toxicity.
Option B: It has low toxicity.
Option C: It has low acute animal toxicity.
Option D: It is associated with significant toxicity.
"	D
16722131	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C(C1(Cl)Cl)(C2=CC=CC=C2)C(=O)OC(C#N)C3=CC(=CC=C3)OC4=CC=CC=C4
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is generally harmless but can harm sensitive individuals.
Option B: It can harm sensitive individuals.
Option C: It can harm sensitive individuals but is generally harmless to human beings in the concentrations used in such products.
Option D: It can harm sensitive individuals, but is generally harmless to human beings in the concentrations used in such products.
"	B
135401907	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=NNC2=C1C(=O)NC=N2
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is a rare but well known cause of acute liver injury that has features of a hypersensitivity reaction and can be severe and even fatal.
Option B: It is an uncommon, but well-established cause of clinically apparent acute and chronic liver injury.
Option C: It is a well-known cause of clinically apparent, acute liver disease that can be severe and even fatal.
Option D: It is a well-known cause of acute clinically apparent liver injury, which can be severe and sometimes fatal.
"	A
6918606	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@H](C1=NC(=CS1)C2=CC=C(C=C2)C#N)[C@](CN3C=[N+](C=N3)C(C)OC(=O)N(C)C4=C(C=CC=N4)COC(=O)CNC)(C5=C(C=CC(=C5)F)F)O
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It avoids the use of a cyclodextrin vehicle for solubilization, eliminating concerns of nephrotoxicity associated with cyclodextrin.
Option B: It has low inhalation hazard and no apparent skin manifestations or other toxicity in humans.
Option C: It generally does not cause nephrotoxicity or fibrosis.
Option D: It does not require cyclodextrin for facilitating drug solubility, which avoids the potential nephrotoxicity associated with cyclodextrin.
"	A
4030	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CC=C3
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It can cause serum enzyme elevations during therapy and rare instances of clinically apparent acute liver injury.
Option B: It is associated with minor transient serum enzyme elevations and has been linked to rare cases of clinically apparent acute liver injury.
Option C: It is associated with a modest rate of serum enzyme elevations and rare instances of clinically apparent, acute liver injury.
Option D: It can cause elevations in serum enzyme levels and rare instances of acute, clinically apparent liver injury.
"	D
2092	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN(CCCNC(=O)C1CCCO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is associated with a low rate of transient serum aminotransferase elevations and rare instances of clinically apparent acute liver injury.
Option B: It is associated with a moderate rate of serum aminotransferase elevations during therapy and rare instances of clinically apparent acute liver injury.
Option C: It is associated with a moderate rate of serum aminotransferase elevations and rare instances of clinically apparent acute liver injury.
Option D: It is associated with a low rate of transient serum aminotransferase elevations and with rare instances of clinically apparent acute liver injury.
"	D
11626560	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is associated with transient elevations in serum aminotransferase levels during treatment and rare instances of clinically apparent acute liver injury.
Option B: It is associated with a moderate rate of transient elevations in serum aminotransferase levels during therapy and with rare instances of clinically apparent acute liver injury.
Option C: It is associated with frequent elevations in serum aminotransferase levels and with rare instances of clinically apparent acute liver injury.
Option D: It has transient elevations in serum aminotransferase levels during therapy and rare instances of clinically apparent acute liver injury.
"	A
3081361	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It often causes mild to moderate elevations in serum aminotransferase levels.
Option B: It is commonly associated with transient elevations in serum aminotransferase during therapy.
Option C: It is associated with transient and usually mild elevations in serum aminotransferase levels.
Option D: It has been associated with mild, transient serum aminotransferase elevations.
"	B
123631	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It exhibits severe muscle toxicity.
Option B: It can cause serious toxicity and possibly death.
Option C: It generally has been shown to be of low acute toxicity.
Option D: It exhibits acute liver toxicity.
"	D
5284537	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(=O)[C@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C=C(C4=CC(=O)[C@@H]5C[C@@H]5[C@]34C)Cl)C)O
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It exhibits rare acute liver toxicity.
Option B: It exhibits severe muscle toxicity.
Option C: It can cause severe liver toxicity.
Option D: It exhibits acute liver toxicity.
"	D
2895	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN(C)CCC=C1C2=CC=CC=C2C=CC3=CC=CC=C31
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It has not been linked to instances of clinically apparent liver injury.
Option B: It has rare occurrences of clinically apparent liver injury.
Option C: It has little evidence of causing liver injury.
Option D: It has been linked to rare instances of clinically apparent liver injury.
"	C
149096	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It can cause rare instances of clinically apparent, acute cholestatic liver injury.
Option B: It can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute cholestatic liver injury.
Option C: It can cause clinically apparent hepatic injury.
Option D: It can cause clinically apparent acute and chronic cholestatic liver injury.
"	C
83975	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(=CC1C(C1(C)C)C(=O)OCN2C(=O)C3=C(C2=O)CCCC3)C
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It can harm sensitive individuals, but in general, it is harmless to human beings.
Option B: It can harm sensitive individuals.
Option C: It can harm sensitive individuals but is generally harmless to human beings in the concentrations used in such products.
Option D: It can harm sensitive individuals, but is generally harmless to human beings in the concentrations used in such products.
"	A
299	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1(=O)C2(C3(C4(C1(C5(C2(C3(C(C45Cl)(Cl)Cl)Cl)Cl)Cl)Cl)Cl)Cl)Cl
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is associated with a risk for severe toxicity and overdose, especially in children.
Option B: It can cause drug overdose and toxicity from accidental ingestion due to its profound sedation effects.
Option C: Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity.
Option D: It is banned due to its toxicity and nature as a persistent organic pollutant.
"	D
104865	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=NC=CC=N3)OCCO)OC4=CC=CC=C4OC
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It has been associated with serum enzyme elevations during therapy and with rare instances of clinically apparent acute liver injury.
Option B: It can cause serum enzyme elevations during therapy and rare instances of clinically apparent acute liver injury.
Option C: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury.
Option D: It has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury.
"	A
91768	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)[C@H](C(=O)OC(C#N)C1=CC(=CC=C1)OC2=CC=CC=C2)NC3=C(C=C(C=C3)C(F)(F)F)Cl
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It can harm sensitive individuals.
Option B: It is generally harmless to human beings but can harm sensitive individuals.
Option C: It can harm sensitive individuals, but in general, it is harmless to human beings.
Option D: It is generally harmless but can harm sensitive individuals.
"	A
25151352	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC(=NC=C1CC2=CNC3=C2C=C(C=N3)Cl)NCC4=CN=C(C=C4)C(F)(F)F
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It can cause liver injury marked by progressive intrahepatic bile duct injury, some of which resulted in liver transplantation or were fatal.
Option B: It can cause an unusual form of liver injury called pseudocirrhosis caused by shrinkage of tumor metastases in the liver combined with desmoplastic changes and vascular damage, that can be severe, progressive and even fatal.
Option C: It can lead to liver injury, jaundice, enlargement of the liver and spleen, portal hypertension, and cirrhosis.
Option D: It has been linked to cases of acute liver injury, including acute cholestatic hepatitis and veno-occlusive disease.
"	A
16004692	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It has a lower risk of hepatotoxicity.
Option B: It can cause hepatotoxicity after an overdose.
Option C: It has hepatotoxic potential.
Option D: It contributes to hepatotoxicity.
"	A
8606	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C=CCC2C1C(=O)N(C2=O)SC(Cl)(Cl)Cl
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It causes histopathological and biochemical changes, including erosion of gastric mucosa and hepatic necrosis.
Option B: It can cause conjunctivitis, rhinitis, rhinoconjunctivitis, bronchitis, and irritation of the skin and mucous membranes of the respiratory tract.
Option C: It can cause dermatitis and conjunctivitis in humans when dermally exposed.
Option D: It can cause ulceration of the gastrointestinal and genitourinary tracts, along with electrolyte and renal function disturbance.
"	C
3224	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C2C(COS(=O)O1)C3(C(=C(C2(C3(Cl)Cl)Cl)Cl)Cl)Cl
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is toxic by ingestion, inhalation, or skin absorption.
Option B: It is toxic by inhalation, skin absorption, or ingestion.
Option C: It may be toxic by ingestion, inhalation, or skin absorption.
Option D: It is toxic by inhalation, ingestion, or skin absorption.
"	B
213013	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C(=C1)C2=CC=C(C=C2)Cl)NC(=O)C3=C(N=CC=C3)Cl
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is moderately toxic to humans, mammals, birds and most aquatic organisms.
Option B: It is moderately toxic to mammals, birds, fish, and aquatic invertebrates.
Option C: It is practically nontoxic to terrestrial animals and is moderately toxic to aquatic animals on an acute exposure basis.
Option D: It is moderately toxic to mammals, birds, earthworms and most aquatic organisms.
"	C
5311309	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)C1CCC(CC1)C(=O)N[C@H](CC2=CC=CC=C2)C(=O)O
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is associated with rare instances of clinically apparent acute liver injury.
Option B: It has rare instances of clinically apparent acute liver injury.
Option C: It has been linked to rare instances of clinically apparent acute liver injury.
Option D: It is linked to rare instances of clinically apparent acute liver injury.
"	C
4696	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C=C2C(=CC(=O)O2)C(O1)O
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is a potential carcinogen.
Option B: It is mildly toxic and carcinogenic.
Option C: It exhibits mild toxicity and is carcinogenic.
Option D: It is genotoxic and may be a carcinogen.
"	D
135409400	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C2=C(C=CC(=C2Cl)Cl)N=C3N1CC(=O)N3
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury.
Option B: It has not been linked to serum enzyme elevations nor to instances of clinically apparent acute liver injury.
Option C: It has not been linked to instances of serum enzyme elevations during therapy or to clinically apparent liver injury.
Option D: It has not been linked to significant serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury.
"	D
9823820	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is associated with a modest rate of serum enzyme elevations and rare instances of clinically apparent, acute liver injury.
Option B: It is associated with a high rate of serum enzyme elevations and rare instances of clinically apparent acute liver injury.
Option C: It can cause mild and transient serum enzyme elevations and is a rare cause of clinically apparent acute liver injury.
Option D: It is associated with minor transient serum enzyme elevations and has been linked to rare cases of clinically apparent acute liver injury.
"	A
135398735	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1/C=C/C=C(\\C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)[C@](O4)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)/C=N/N5CCN(CC5)C)/C
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is a rare but well known cause of acute liver injury that has features of a hypersensitivity reaction and can be severe and even fatal.
Option B: It is an uncommon, but well-established cause of clinically apparent acute and chronic liver injury.
Option C: It is a well-known cause of clinically apparent, acute liver disease that can be severe and even fatal.
Option D: It is a well-known cause of acute clinically apparent liver injury, which can be severe and sometimes fatal.
"	C
148195	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CN(CCC1CC(=O)N2CCC(CC2)[C@@H]3C4=C(CCC5=C3N=CC(=C5)Br)C=C(C=C4Br)Cl)C(=O)N
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It has been associated with mild, transient serum aminotransferase elevations.
Option B: It often causes mild to moderate elevations in serum aminotransferase levels.
Option C: It is associated with transient and usually mild elevations in serum aminotransferase levels.
Option D: It causes moderate serum aminotransferase elevations.
"	C
6438357	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@H]1[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)C(=C)N(C(=O)CC[C@@H](NC1=O)C(=O)O)C)C)CCCN=C(N)N)C(=O)O)C)CCCN=C(N)N)/C=C/C(=C/[C@H](C)[C@H](CC2=CC=CC=C2)OC)/C
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It more commonly causes transient elevations in serum aminotransferases without jaundice, but has been linked to rare instances of clinically apparent, idiosyncratic liver injury.
Option B: Elevations in serum enzyme levels during therapy with this molecule are uncommon, and it has yet to be convincingly implicated in cases of idiosyncratic liver injury with jaundice.
Option C: It is hepatotoxic, although found to be up to 10-fold less toxic than microcystin-LR on intraperitoneal injection injection in mice.
Option D: It has been linked to serum aminotransferase elevations during therapy and to a clinically apparent, idiosyncratic liver injury that is typically cholestatic and self-limited in course.
"	C
135398745	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC2=C(S1)NC3=CC=CC=C3N=C2N4CCN(CC4)C
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is associated with transient elevations in serum aminotransferase levels and rare instances of clinically apparent acute liver injury.
Option B: It can be associated with transient, usually asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury.
Option C: It is associated with transient elevations in serum aminotransferase levels during therapy and has been reported to cause clinically apparent acute liver injury and rare instances of death.
Option D: It can cause serum aminotransferase elevations during therapy and there have been rare instances of clinically apparent acute liver injury linked to its use.
"	D
73484	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C[C@H]2[C@@H](CC3=CNC4=CC=CC2=C34)N(C1)C
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It can cause ergotism, a disease causing convulsive and gangrenous symptoms.
Option B: Acute exposure to high concentrations of it can cause pulmonary edema, coughing, and shortness of breath in humans.
Option C: It can cause convulsive and gangrenous symptoms.
Option D: It can cause drug overdose and toxicity from accidental ingestion due to its profound sedation effects.
"	A
64143	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(C=CC=C1O)C(=O)N[C@@H](CSC2=CC=CC=C2)[C@@H](CN3C[C@H]4CCCC[C@H]4C[C@H]3C(=O)NC(C)(C)C)O
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It can cause transient and usually asymptomatic elevations in serum aminotransferase levels and is a rare cause of clinically apparent, acute liver injury.
Option B: It can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury.
Option C: It can be associated with transient, usually asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury.
Option D: It is associated with transient elevations in serum aminotransferase levels and rare instances of clinically apparent acute liver injury.
"	A
9853053	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C(=O)NCC(F)(F)F
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It has been linked to cases of acute liver injury, including acute cholestatic hepatitis and veno-occlusive disease.
Option B: It can cause both an acute hepatitis-like syndrome and a more insidious chronic hepatitis with autoimmune features.
Option C: It is linked to the development of steatohepatitis and hepatic fibrosis with long-term therapy.
Option D: It can cause minor transient serum enzyme elevations and has been linked to cases of acute liver injury including cholestatic hepatitis and acute veno-occlusive disease.
"	C
36921	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CSC=C3)C(=O)O)C(=O)O)C
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It has been linked with idiosyncratic liver injury, but only rarely and as isolated case reports.
Option B: It has been linked with idiosyncratic liver injury, but only rarely and in isolated case reports.
Option C: It has been associated with idiosyncratic, clinically apparent acute liver injury.
Option D: It has been linked to rare instances of idiosyncratic, clinically apparent acute liver injury.
"	A
2913	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CCC(=C2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It has been linked to rare instances of clinically apparent liver injury.
Option B: It has been linked to rare instances of clinically apparent acute liver injury.
Option C: It is linked to rare instances of clinically apparent acute liver injury.
Option D: It has been associated with rare instances of clinically apparent liver injury.
"	A
5479537	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[N+]1(CCCC1)CC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\\OC)/C4=CSC(=N4)N)SC2)C(=O)[O-]
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It may cause neurotoxicity, especially in patients with renal impairment.
Option B: It has been associated with occasional cases of severe and distinctive acute hepatic failure.
Option C: It has the potential for serious morbidity and mortality with over dosage.
Option D: It has neurotoxic effects and potential serious neuropsychiatric effects.
"	A
441289	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@@H]([C@]2(C[C@@H]1[N+]4(CCCCC4)C)C)CC[C@]5([C@H]3C[C@@H]([C@@H]5OC(=O)C)[N+]6(CCCCC6)C)C
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It has less effect on the circulatory system and on histamine release.
Option B: It contributes to hepatotoxicity.
Option C: It has a lower risk of hepatotoxicity.
Option D: It is associated with a risk of hepatotoxicity.
"	A
48041	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CCCCC1CCC2=CC=CC=C2NC(=O)C3=CC=C(C=C3)OC
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is associated with a high rate of transient serum enzyme elevations during treatment and occasional instances of clinically apparent liver injury with jaundice.
Option B: It has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent acute liver injury with jaundice.
Option C: It has been associated with serum enzyme elevations during therapy and with rare instances of clinically apparent acute liver injury.
Option D: It is associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack.
"	D
11826859	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)(C(=O)OCC=C)OC(=O)C1=C(C=CC(=C1)N2C(=O)C=C(N(C2=O)C)C(F)(F)F)Cl
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: Ingestion of a large amount of this molecule can result in tinnitus, dizziness, headache, nausea, vomiting, dyspnea, erosion of the gastric mucosa, edema of internal organs, cyanosis, convulsions, delirium, and collapse in humans.
Option B: It can cause inflammation and irritation to the urinary bladder and urethra, and similar changes have recently been described in the biliary tract, resulting in an acute or chronic cholestatic liver injury that can resemble sclerosing cholangitis.
Option C: It primarily causes hematological effects such as decreased hemoglobin, hematocrit, mean corpuscular hemoglobin (MCH), and mean corpuscular volume (MCV), and increased red cell volume.
Option D: It can lead to acute psychosis, aggressive and violent behaviors, and overdoses can cause status epilepticus, hyperthermia, rhabdomyolysis and subsequent renal, respiratory and hepatic failure.
"	C
27661	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1[C@@H]([C@@H]2[C@H](O1)[C@@H](CO2)O[N+](=O)[O-])O
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is toxic by inhalation and ingestion.
Option B: It is toxic by ingestion and inhalation.
Option C: It is very toxic by inhalation and ingestion.
Option D: It may be toxic by ingestion.
"	D
54676228	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=CC=CC=N3
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It can cause clinically apparent acute liver injury that can be severe and even fatal.
Option B: It is associated with rare instances of clinically apparent, acute liver injury that can be severe and even fatal.
Option C: It has been linked to rare instances of acute liver injury that can be severe and even fatal.
Option D: It can cause clinically apparent liver injury that can be severe and even fatal.
"	A
5362129	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2[C@H]3CCC[C@H]3C[C@H]2C(=O)O
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is associated with a low rate of transient serum aminotransferase elevations and rare instances of acute liver injury.
Option B: It has a low rate of transient serum aminotransferase elevations and rare instances of acute liver injury.
Option C: It has a low rate of transient serum aminotransferase elevations and has been linked to rare instances of acute liver injury.
Option D: It is associated with a low rate of transient serum aminotransferase elevations and with rare instances of clinically apparent acute liver injury.
"	C
5053	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(=CC1C(C1(C)C)C(=O)OCC2=COC(=C2)CC3=CC=CC=C3)C
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It can harm sensitive individuals but is generally harmless to human beings in the concentrations used in such products.
Option B: It can harm sensitive individuals, but is generally harmless to human beings in the concentrations used in such products.
Option C: It is generally harmless but can harm sensitive individuals.
Option D: It is generally harmless to human beings but can harm sensitive individuals.
"	B
51683	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1C[C@H]([C@@H]2[C@@H]([C@@H](CN2C1)O)O)O
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is a neurotoxin that blocks neural messages and binds particularly tightly in the central nervous system of insects, causing rapid death.
Option B: It can cause a potentially lethal central nervous system condition known as locoism in livestock.
Option C: It primarily targets the central nervous system (CNS) for toxicity in both humans and animals.
Option D: It can cause neurotoxicity in humans, including numbness, cyanosis, hyperesthesia, and muscle spasms.
"	B
444008	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@H]1CC2=C(CCC(=O)C2)[C@@H]3[C@@H]1[C@@H]4CC[C@]([C@]4(CC3)C)(C#C)O
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It has rare instances of clinically apparent acute liver injury.
Option B: It has been associated with rare instances of acute, clinically apparent liver injury.
Option C: It is associated with rare instances of clinically apparent acute liver injury.
Option D: It is linked to rare instances of clinically apparent acute liver injury.
"	B
193962	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=CC(=C1OC2=NC(=NC(=C2Br)N)NC3=CC=C(C=C3)C#N)C)C#N
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It can cause serum aminotransferase elevations during therapy and there have been rare instances of clinically apparent acute liver injury linked to its use.
Option B: It is associated with a low rate of transient serum aminotransferase elevations during therapy and rare cases of clinically apparent acute liver injury.
Option C: It is associated with a moderate rate of serum aminotransferase elevations during therapy and rare instances of clinically apparent acute liver injury.
Option D: It has been associated with hypersensitivity reactions that can be associated with liver injury including acute liver failure, as well as transient serum aminotransferase elevations.
"	D
73670	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C(=C1)C2=NN=C(N=N2)C3=CC=CC=C3Cl)Cl
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It exhibits hepatotoxicity and changes to the thyroid, including follicular hyperplasia.
Option B: It affects the liver, including hepatitis and jaundice, and central nervous system effects, such as depression and irritability.
Option C: It can lead to liver injury, jaundice, enlargement of the liver and spleen, portal hypertension, and cirrhosis.
Option D: It can cause neurotoxicity in humans, including numbness, cyanosis, hyperesthesia, and muscle spasms.
"	A
43672	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCN1CCN(C(=O)C1=O)C(=O)N[C@H](C2=CC=CC=C2)C(=O)N[C@H]3[C@@H]4N(C3=O)[C@H](C(S4)(C)C)C(=O)O
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It has been associated with idiosyncratic, clinically apparent acute liver injury.
Option B: It has been linked with idiosyncratic liver injury, but only rarely and as isolated case reports.
Option C: It has been linked to rare cases of idiosyncratic, clinically apparent liver injury.
Option D: It has been linked with idiosyncratic liver injury, but only rarely and in isolated case reports.
"	D
57379345	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=C(C=C1C2CCNCC2)OC(C)C)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)C(C)C)Cl
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It is associated with a moderate rate of serum aminotransferase elevations during therapy and rare instances of clinically apparent acute liver injury.
Option B: It is associated with a moderate rate of serum aminotransferase elevations and rare instances of clinically apparent acute liver injury.
Option C: It is associated with a low rate of transient serum aminotransferase elevations during therapy and rare cases of clinically apparent acute liver injury.
Option D: It has a moderate rate of serum aminotransferase elevations during therapy and rare instances of clinically apparent acute liver injury.
"	D
6433396	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1N2CN3CN1C[N+](C2)(C3)C/C=C/Cl.[Cl-]
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It exhibits mild toxicity and is carcinogenic.
Option B: It is toxic and may be carcinogenic.
Option C: It is toxic and carcinogenic.
Option D: It can react and release formaldehyde and nitrosamines, both of which are believed to be carcinogenic.
"	D
135423438	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N=C(C3=CC=CC=C3)C4=C(NC5=C4C=CC(=C5)C(=O)OC)O
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It can cause elevations in serum enzyme levels, but has yet to be implicated in cases of clinically apparent liver injury with jaundice.
Option B: It has had limited clinical use and has not been linked to serum enzyme elevations or instances of clinically apparent liver injury with jaundice.
Option C: It can be associated with mild serum enzyme elevations, but has yet to be linked to instances of clinically apparent liver injury with jaundice.
Option D: It has yet to be implicated in cases of clinically apparent liver injury with jaundice.
"	D
5533	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CN(CCN1CCCN2C(=O)N3C=CC=CC3=N2)C4=CC(=CC=C4)Cl
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It has been linked to rare instances of clinically apparent acute liver injury.
Option B: It can be associated with rare instances of clinically apparent acute liver injury.
Option C: It is associated with rare instances of clinically apparent acute liver injury.
Option D: It is linked to rare instances of clinically apparent acute liver injury.
"	B
4463	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C2C(=NC=C1)N(C3=C(C=CC=N3)C(=O)N2)C4CC4
Question about this molecule: Which kind of toxicity does this molecule have/exhibit?
Option A: It has been associated with rare instances of acute, clinically apparent liver injury.
Option B: It can cause rare instances of acute, clinically apparent liver injury.
Option C: It is a well established cause of acute, clinically apparent liver injury.
Option D: It can be associated with rare instances of clinically apparent acute liver injury.
"	C
91754	"Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)(C)C1=CC=C(C=C1)CSC2=C(C(=O)N(N=C2)C(C)(C)C)Cl
Question about this molecule: How is the volatileness of this molecule
Option A: It is not very volatile.
Option B: It is not considered particularly volatile.
Option C: It is not volatile.
Option D: It is slightly volatile at ordinary temperatures.
"	B