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1.0alpha7.train.375
6974947
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1.0alpha7.train.376
9103599
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1.0alpha7.train.377
3584988
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1.0alpha7.train.378
12609808
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1.0alpha7.train.379
11484185
[ { "id": "1.0alpha7.train.379.sent", "type": "sentence", "text": [ " Additional evidence that FKBP12 specifically recognizes the Leu-Pro motif is provided by previous reports (Okadome et al., 1996; Wang et al., 1996b) and present observations that rapamycin and FK506 inhibit FKBP12 binding to TbetaR-I. " ], "offsets": [ [ 0, 245 ] ] } ]
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1.0alpha7.train.380
2164945
[ { "id": "1.0alpha7.train.380.sent", "type": "sentence", "text": [ " C, Diva does not bind to Bcl-XL in 293T cells. " ], "offsets": [ [ 0, 51 ] ] } ]
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1.0alpha7.train.381
4118469
[ { "id": "1.0alpha7.train.381.sent", "type": "sentence", "text": [ "EMSA of NF-Y and HSP-CBF bound to the HSP70 (A) and HSP40 (B) proximal CCAAT box regions." ], "offsets": [ [ 0, 89 ] ] } ]
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1.0alpha7.train.382
3573954
[ { "id": "1.0alpha7.train.382.sent", "type": "sentence", "text": [ "The ability of the specific K266A mutant to abolish binding of AIP to hsp90 and substantially reduce binding to AhR, coupled with the ability of AIP to bind directly to hsp90 and the pharmacological characterization of the binding of AIP to AhR, provides compelling evidence that hsp90 is required for binding between AhR and AIP." ], "offsets": [ [ 0, 330 ] ] } ]
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1.0alpha7.train.383
15592346
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[]
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1.0alpha7.train.384
15237557
[ { "id": "1.0alpha7.train.384.sent", "type": "sentence", "text": [ " Finally, the significance of the fact that TFIID (and TFIIA) binds both TFIID-dependent and TFIID-independent promoters ( 42) with comparable efficiency (in vitro) also awaits further study. " ], "offsets": [ [ 0, 197 ] ] } ]
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[]
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1.0alpha7.train.385
15338391
[ { "id": "1.0alpha7.train.385.sent", "type": "sentence", "text": [ " It is possible, therefore, that, upon the binding of GRF2 to Ras, the DB is exposed to the ubiquitination machinery, resulting in the ubiquitination of GRF2. " ], "offsets": [ [ 0, 164 ] ] } ]
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[]
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1.0alpha7.train.386
3950115
[ { "id": "1.0alpha7.train.386.sent", "type": "sentence", "text": [ " Obviously, the immunoblots will show whether or not PTN binds to the ALK ECD, but they will not reveal as to whether other unidentified proteins present in the PTN preparation also bind. " ], "offsets": [ [ 0, 195 ] ] } ]
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[]
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1.0alpha7.train.387
16061165
[ { "id": "1.0alpha7.train.387.sent", "type": "sentence", "text": [ " HP1 chromodomain does not bind histone H3 containing methyllysine 4 ( 7), a posttranslational modification associated with transcriptional activation ( 18), because the sequence context of the Lys4 (ARTK4Q) is not shared with Lys9. " ], "offsets": [ [ 0, 241 ] ] } ]
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[]
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1.0alpha7.train.388
1986162
[ { "id": "1.0alpha7.train.388.sent", "type": "sentence", "text": [ " In addition to binding filamin, it has been previously reported that beta1 can bind focal adhesion kinase ( 52) and the cytoplasmic proteins talin ( 53), paxillin ( 52), and alpha-actinin ( 54). " ], "offsets": [ [ 0, 203 ] ] } ]
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[]
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1.0alpha7.train.389
18041722
[ { "id": "1.0alpha7.train.389.sent", "type": "sentence", "text": [ "Second, the ankyrin repeat-containing serine-threonine kinase, integrin-linked kinase (ILK), which binds the cytoplasmic domain of β1 and β3 integrin subunits, promotes contact-independent growth and directly induces cyclin D1 expression and transcription (D'Amico et al., 2000)." ], "offsets": [ [ 0, 279 ] ] } ]
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[]
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1.0alpha7.train.390
9239313
[ { "id": "1.0alpha7.train.390.sent", "type": "sentence", "text": [ "U2AF bound to the PY tract and AG within exon 3 recruits U2 snRNP to the BPS." ], "offsets": [ [ 0, 77 ] ] } ]
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[]
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1.0alpha7.train.391
3182612
[ { "id": "1.0alpha7.train.391.sent", "type": "sentence", "text": [ "It has been reported that ligands (e.g. echistatin) or RGD-containing peptides block binding of an RGD-containing anti-β3 antibody, 16N7C2, to β3 integrin (19)." ], "offsets": [ [ 0, 160 ] ] } ]
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[]
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1.0alpha7.train.392
21892012
[ { "id": "1.0alpha7.train.392.sent", "type": "sentence", "text": [ " A further complication arises if it can be confirmed that Munc13-1 binding to syntaxin is not affected by phorbol esters (see Rhee et al., 2002 , p. 131). " ], "offsets": [ [ 0, 163 ] ] } ]
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[]
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1.0alpha7.train.393
1731631
[ { "id": "1.0alpha7.train.393.sent", "type": "sentence", "text": [ " Several individual amino acid residues in Shc have been implicated by site-directed mutagenesis to be critical for Shc binding to the psi XNP XpY motif ( 17, 19, 20). " ], "offsets": [ [ 0, 174 ] ] } ]
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[]
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1.0alpha7.train.394
16045025
[ { "id": "1.0alpha7.train.394.sent", "type": "sentence", "text": [ "As adapter proteins, Shc binds to activated receptors such as epidermal growth factor, nerve growth factor, and antigen receptors, and IRS binds to activated insulin receptor, so as to transduce signals to downstream effector proteins (reviewed in reference 37)." ], "offsets": [ [ 0, 262 ] ] } ]
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[]
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1.0alpha7.train.395
15088726
[ { "id": "1.0alpha7.train.395.sent", "type": "sentence", "text": [ "HSP27 binds to the 26S proteasome complex." ], "offsets": [ [ 0, 42 ] ] } ]
[ { "id": "1.0alpha7.train.395.ent0_0", "type": "protein", "text": [ "HSP27" ], "offsets": [ [ 0, 5 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3315" }, { "db_name": "hgnc", "db_id": "HSPB1" }, { "db_name": "uniprot", "db_id": "P04792" } ] }, { "id": "1.0alpha7.train.395.ent1_0", "type": "protein-complex", "text": [ "26S proteasome complex" ], "offsets": [ [ 19, 41 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.396
11579877
[ { "id": "1.0alpha7.train.396.sent", "type": "sentence", "text": [ "MSL complex binding at roX1 transgenes requires MLE." ], "offsets": [ [ 0, 55 ] ] } ]
[ { "id": "1.0alpha7.train.396.ent0_0", "type": "protein-complex", "text": [ "MSL" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "1.0alpha7.train.396.ent1_0", "type": "DNA", "text": [ "roX1" ], "offsets": [ [ 25, 29 ] ], "normalized": [] }, { "id": "1.0alpha7.train.396.ent2_0", "type": "protein", "text": [ "MLE" ], "offsets": [ [ 51, 54 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.397
11977641
[ { "id": "1.0alpha7.train.397.sent", "type": "sentence", "text": [ "The reduction in ordering of C-terminal portions of the CRIB motif on binding the GTPase, and consequent reduction of a significant conformational entropic penalty on binding, may explain how Par6 can bind Cdc42 with high affinity even though its CRIB motif lacks conserved elements found in other systems (Burbelo et al., 1995)." ], "offsets": [ [ 0, 329 ] ] } ]
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[]
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1.0alpha7.train.398
11349322
[ { "id": "1.0alpha7.train.398.sent", "type": "sentence", "text": [ "Taking advantage of the fact that high Ca2+ concentrations can be easily achieved in solution to detect weak binding sites, we have now determined the complete Ca2+‐binding mode of the C2A‐domain of synaptotagmin I using a combination of Mn2+‐induced relaxation experiments, site‐directed mutagenesis and Ca2+ titrations monitored by NMR spectroscopy." ], "offsets": [ [ 0, 351 ] ] } ]
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[]
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1.0alpha7.train.399
2874772
[ { "id": "1.0alpha7.train.399.sent", "type": "sentence", "text": [ " Buffers contained 10 muM FAD; binding was carried out at 40 mM imidazole, washing at 60 mM, and elution at 400 mM for the first cycle and 300 mM for the second. " ], "offsets": [ [ 0, 165 ] ] } ]
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[]
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[]
1.0alpha7.train.400
14195597
[ { "id": "1.0alpha7.train.400.sent", "type": "sentence", "text": [ "Since the ggp1Δ mutant of S. cerevisiae is sensitive to Calcofluor White (CF) (Sigma, St. Louis, Mo.), a fluorescent stain that binds to nascent chitin molecules and prevents their assembly into fibrils (2), we tested if the phr1Δ mutant had similar behavior with respect to this compound. " ], "offsets": [ [ 0, 290 ] ] } ]
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[]
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1.0alpha7.train.401
25196729
[ { "id": "1.0alpha7.train.401.sent", "type": "sentence", "text": [ "The syntaxin-1a-Munc18 complex was further incubated with various quantities of tomosyn on the membranes for 2 hr. Syntaxin-1a bound to tomosyn was detected." ], "offsets": [ [ 0, 161 ] ] } ]
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[]
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1.0alpha7.train.402
20172896
[ { "id": "1.0alpha7.train.402.sent", "type": "sentence", "text": [ "If the engrailed-2 gene were a direct target of Wnt signaling, which worked through β-catenin binding to LEF/TCF homologs on the promoter, then one would predict that induction of the engrailed-2 gene by Wnt and β-catenin could be blocked by a dominant negative TCF." ], "offsets": [ [ 0, 266 ] ] } ]
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[]
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1.0alpha7.train.403
1931877
[ { "id": "1.0alpha7.train.403.sent", "type": "sentence", "text": [ " Sp1, Sp3, and Sp4 bind to the GC box of the ODC promoter. " ], "offsets": [ [ 0, 64 ] ] } ]
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[]
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1.0alpha7.train.404
3584980
[ { "id": "1.0alpha7.train.404.sent", "type": "sentence", "text": [ " Based on the present study, we propose that Axam may form a complex with Axin constitutively in the absence of Wnt, thereby Dvl does not bind to Axin. " ], "offsets": [ [ 0, 158 ] ] } ]
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1.0alpha7.train.405
1845538
[ { "id": "1.0alpha7.train.405.sent", "type": "sentence", "text": [ " To further map the PR binding motif of RIZ proteins, truncation mutants of RIZ1 were generated by in vitro transcription and translation of various mutant constructs (Fig. 5 A). " ], "offsets": [ [ 0, 190 ] ] } ]
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[]
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1.0alpha7.train.406
23330418
[ { "id": "1.0alpha7.train.406.sent", "type": "sentence", "text": [ "First, we tested whether anti-L1 Fab remains bound to L1 in endosomal compartments whose pH is slightly acidic: pH 6.0-6.5 in early endosomes and pH 5.0-6.0 in late endosomes (Nixon and Cataldo, 1995)." ], "offsets": [ [ 0, 201 ] ] } ]
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[]
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[]
1.0alpha7.train.407
15411318
[ { "id": "1.0alpha7.train.407.sent", "type": "sentence", "text": [ " In NBS cells, neither Nbs1p70 nor Mre11 bound to E2F sites, whereas E2F1 binding was unaffected (Fig. 3C). " ], "offsets": [ [ 0, 114 ] ] } ]
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[]
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1.0alpha7.train.408
20250431
[ { "id": "1.0alpha7.train.408.sent", "type": "sentence", "text": [ "dCtBP also binds to Hairy and a number of transcriptional repressors." ], "offsets": [ [ 0, 71 ] ] } ]
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[]
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1.0alpha7.train.409
11989537
[ { "id": "1.0alpha7.train.409.sent", "type": "sentence", "text": [ " PIP2 also binds to vinculin, which then interacts with talin. " ], "offsets": [ [ 0, 66 ] ] } ]
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[]
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1.0alpha7.train.410
20472368
[ { "id": "1.0alpha7.train.410.sent", "type": "sentence", "text": [ "Concurrent binding of Sp1 and AP2 to the hTAFII55 promoter-proximal region The extended footprints exhibited by individual Sp1 and AP2 proteins raise an interesting possibility that both proteins may bind simultaneously to the hTAFII55 promoter." ], "offsets": [ [ 0, 253 ] ] } ]
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[]
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1.0alpha7.train.411
9621758
[ { "id": "1.0alpha7.train.411.sent", "type": "sentence", "text": [ " Spectrin, which binds to F-actin beneath plasma membrane and forms a membrane cortical meshwork, also accumulates at the leading edges of motile cells (Burridge et al., 1982 ; Sormunen and Lehto, 1995 ). " ], "offsets": [ [ 0, 211 ] ] } ]
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1.0alpha7.train.412
762988
[ { "id": "1.0alpha7.train.412.sent", "type": "sentence", "text": [ " Although the residual activity was close to background, TPA may still be bound to PKC and thereby maintain phosphorylation and activation of the substrate. " ], "offsets": [ [ 0, 160 ] ] } ]
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[]
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1.0alpha7.train.413
553419
[ { "id": "1.0alpha7.train.413.sent", "type": "sentence", "text": [ "Paxillin failed to bind to GST alone or to the SH2 domain of Grb2." ], "offsets": [ [ 0, 70 ] ] } ]
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[]
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1.0alpha7.train.414
11787497
[ { "id": "1.0alpha7.train.414.sent", "type": "sentence", "text": [ " While the region of Apaf-1 that is involved in binding with Hsp90 is not known, our results demonstrate that Hsp90 binds to Apaf-1 at a different site than that of cyt c (data not shown). " ], "offsets": [ [ 0, 195 ] ] } ]
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[]
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1.0alpha7.train.415
9615473
[ { "id": "1.0alpha7.train.415.sent", "type": "sentence", "text": [ " Since direct binding of PAK to paxillin was not observed, the precipitation of PAK by paxillin LD4 from cell and tissue lysates likely occurs as a result of its association with PIX (Fig. 7; Bagrodia et al., 1998 ; Manser et al., 1998 ). " ], "offsets": [ [ 0, 249 ] ] } ]
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[]
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1.0alpha7.train.416
2941175
[ { "id": "1.0alpha7.train.416.sent", "type": "sentence", "text": [ "Munc18a is at once essential and inhibitory to secretion (8) because while Sec1p and its homologues are necessary for membrane trafficking and the final stages of protein secretion (9, 10), high affinity binding between Munc18a and syntaxin 1a also inhibits the association of vesicle SNAREs with syntaxin 1a (5-7, 11)." ], "offsets": [ [ 0, 319 ] ] } ]
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[]
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1.0alpha7.train.417
3470292
[ { "id": "1.0alpha7.train.417.sent", "type": "sentence", "text": [ " A program of study focused on identifying these binding site(s) ( 5, 6, 46, 47) culminated in the discovery that synaptotagmin I bound AP-2 with high affinity in vitro ( 7). " ], "offsets": [ [ 0, 182 ] ] } ]
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[]
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1.0alpha7.train.418
2068064
[ { "id": "1.0alpha7.train.418.sent", "type": "sentence", "text": [ " The percent tsf mutant coat protein bound to GroEL, however, does show a dependence upon GroEL/S concentration. " ], "offsets": [ [ 0, 117 ] ] } ]
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[]
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1.0alpha7.train.419
18178818
[ { "id": "1.0alpha7.train.419.sent", "type": "sentence", "text": [ " This was not because of reduced binding of cyclin A to the Cdk2, because cyclin A strongly activated the histone H1 kinase activity of the Texas Red-labeled GST-Cdk2 preparation (data not shown). " ], "offsets": [ [ 0, 203 ] ] } ]
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[]
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1.0alpha7.train.420
2986894
[ { "id": "1.0alpha7.train.420.sent", "type": "sentence", "text": [ " Further, adaptor proteins such as FE65, whose protein interaction domains bind the cytoplasmic portions of both LRP and APP ( 37), may also be involved in linking these two molecules. " ], "offsets": [ [ 0, 191 ] ] } ]
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[]
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1.0alpha7.train.421
15771301
[ { "id": "1.0alpha7.train.421.sent", "type": "sentence", "text": [ " Lanes 16 and 17 are a longer autoradiographic exposure of lanes 14 and 15, to more clearly demonstrate the previously reported observation that MEIS1 binds to HOXA9 in the absence of PBX proteins ( 41). " ], "offsets": [ [ 0, 209 ] ] } ]
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[]
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1.0alpha7.train.422
20260622
[ { "id": "1.0alpha7.train.422.sent", "type": "sentence", "text": [ " Confirming the two-hybrid data, DCAP binds to Axin ( Fig. 3, right panel). " ], "offsets": [ [ 0, 80 ] ] } ]
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[]
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1.0alpha7.train.423
22807496
[ { "id": "1.0alpha7.train.423.sent", "type": "sentence", "text": [ " The model suggests that Ral is bound to PLD but cannot directly activate the enzyme; therefore other molecules, such as Arf, Rac, or Rho are necessary for a fully activated signaling complex. " ], "offsets": [ [ 0, 199 ] ] } ]
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[]
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1.0alpha7.train.424
12711193
[ { "id": "1.0alpha7.train.424.sent", "type": "sentence", "text": [ " Regulation of 3' splice site choice, both positive and negative, can be realized by influencing the pyrimidine tract binding of U2AF (Tian and Maniatis 1993 ; Valcarcel et al. 1993 ; Reed 1996 ). " ], "offsets": [ [ 0, 203 ] ] } ]
[ { "id": "1.0alpha7.train.424.ent0_0", "type": "DNA", "text": [ "pyrimidine tract" ], "offsets": [ [ 102, 118 ] ], "normalized": [] }, { "id": "1.0alpha7.train.424.ent1_0", "type": "protein-family", "text": [ "U2AF" ], "offsets": [ [ 131, 135 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.425
24577808
[ { "id": "1.0alpha7.train.425.sent", "type": "sentence", "text": [ " In this light, it is interesting that the wild-type GSK3 strongly stimulated the binding of Axin to LRP-5, whereas a kinase-dead GSK3 did not. " ], "offsets": [ [ 0, 149 ] ] } ]
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[]
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1.0alpha7.train.426
12486893
[ { "id": "1.0alpha7.train.426.sent", "type": "sentence", "text": [ "ASF/SF2 binds a purine-rich element positioned within the 3'UTR of the mature PKCI-r mRNA." ], "offsets": [ [ 0, 94 ] ] } ]
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[]
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1.0alpha7.train.427
11846855
[ { "id": "1.0alpha7.train.427.sent", "type": "sentence", "text": [ " To investigate whether the K12 and K23 double mutations in eIF2beta reduced binding between eIF2 and eIF5 in vitro, we conducted pull-down assays with GST-eIF5 and wild-type or mutant eIF2 present in WCEs. " ], "offsets": [ [ 0, 216 ] ] } ]
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[]
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1.0alpha7.train.428
6744203
[ { "id": "1.0alpha7.train.428.sent", "type": "sentence", "text": [ " As shown in Fig. 3 E, when 8-azido-[gamma-32] GTP was covalently bound to Rad, addition of nm23 caused reduction in amount of [gamma-32] labeling on Rad, indicating that GTP was being hydrolyzed in situ. " ], "offsets": [ [ 0, 212 ] ] } ]
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[]
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1.0alpha7.train.429
11231991
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1.0alpha7.train.430
4638492
[ { "id": "1.0alpha7.train.430.sent", "type": "sentence", "text": [ "A18 hnRNP Binds Specifically to RPA2 and Thioredoxin 3′-UTRs" ], "offsets": [ [ 0, 60 ] ] } ]
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1.0alpha7.train.432
9849120
[ { "id": "1.0alpha7.train.432.sent", "type": "sentence", "text": [ "As shown in Fig. 3 B, lane 2, phosphorylated p97 bound to p47." ], "offsets": [ [ 0, 62 ] ] } ]
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1.0alpha7.train.433
1550912
[ { "id": "1.0alpha7.train.433.sent", "type": "sentence", "text": [ " In this experiment, any binding of heparin to Abeta should have been revealed as a series of electrophoretic bands whose mobility was progressively increased by increasing heparin concentrations. " ], "offsets": [ [ 0, 201 ] ] } ]
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[]
1.0alpha7.train.434
15814807
[ { "id": "1.0alpha7.train.434.sent", "type": "sentence", "text": [ "(A) Conservation of the CtBP binding motif PLDLSL among mouse deltaEF1 and adenovirus (Ad) E1A proteins." ], "offsets": [ [ 0, 107 ] ] } ]
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[]
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1.0alpha7.train.435
1630826
[ { "id": "1.0alpha7.train.435.sent", "type": "sentence", "text": [ "The basic properties of the side chain of lysine 13, together with the observation that ATP protected this residue against modification by pyridoxal phosphate, not only argues for an active-site location for this lysine but also prompts speculation that lysine 13 could stabilize ATP binding because of interaction between the positively charged ϵ-amino group and the negatively charged phosphoryl groups of ATP." ], "offsets": [ [ 0, 412 ] ] } ]
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[]
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[]
1.0alpha7.train.436
7266947
[ { "id": "1.0alpha7.train.436.sent", "type": "sentence", "text": [ " This latter hypothesis would be in agreement with the fact that overexpression of GTP-bound forms of rab proteins generally results in a gain of function ( 2, 3). " ], "offsets": [ [ 0, 168 ] ] } ]
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[]
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1.0alpha7.train.437
16448553
[ { "id": "1.0alpha7.train.437.sent", "type": "sentence", "text": [ "Dynamin 2, a binding partner of the SH3 domain of amphiphysin (9), was recruited to the tubules when coexpressed with M-amphiphysin 2 (Fig. 2D), but not when coexpressed with its BAR* domain, which was sufficient to induce tubulation (Fig. 2, B and E)." ], "offsets": [ [ 0, 252 ] ] } ]
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[]
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1.0alpha7.train.438
24683820
[ { "id": "1.0alpha7.train.438.sent", "type": "sentence", "text": [ "Next we compared the binding of PR and NF1 to the MMTV promoter presented either as free DNA or in minichromosomes." ], "offsets": [ [ 0, 118 ] ] } ]
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[]
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1.0alpha7.train.439
12893112
[ { "id": "1.0alpha7.train.439.sent", "type": "sentence", "text": [ "Binding of trithorax and Polycomb proteins to the bithorax complex: dynamic changes during early Drosophila embryogenesis." ], "offsets": [ [ 0, 122 ] ] } ]
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[]
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1.0alpha7.train.440
1262529
[ { "id": "1.0alpha7.train.440.sent", "type": "sentence", "text": [ "p100 bound directly to the SH2 domains of both SHP-2 and the p85 subunit of phosphatidylinositol 3-kinase." ], "offsets": [ [ 0, 109 ] ] } ]
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[]
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1.0alpha7.train.441
25205144
[ { "id": "1.0alpha7.train.441.sent", "type": "sentence", "text": [ "To further test whether CDI results from an action of endogenous calmodulin, whole-cell NMDA receptor-mediated currents were recorded following the infusion of a calmodulin binding peptide (CBP) into NR1/NR2A-expressing HEK 293 cells to reduce intracellular free calmodulin." ], "offsets": [ [ 0, 274 ] ] } ]
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[]
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1.0alpha7.train.442
1352390
[ { "id": "1.0alpha7.train.442.sent", "type": "sentence", "text": [ "This phosphorylation is crucial for Shc binding to Grb2 and MT-induced transformation." ], "offsets": [ [ 0, 89 ] ] } ]
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[]
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1.0alpha7.train.443
5927999
[ { "id": "1.0alpha7.train.443.sent", "type": "sentence", "text": [ " The PH domain, which binds PI(4,5) P2 ( 14, 15), and an amino acid stretch upstream of PH domain, which can insert into the lipid bilayer ( 16), help the protein to anchor at the membrane. " ], "offsets": [ [ 0, 194 ] ] } ]
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[]
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1.0alpha7.train.444
3472848
[ { "id": "1.0alpha7.train.444.sent", "type": "sentence", "text": [ "Procaspase-9 without cytochrome c had no effect on dATP binding to Apaf-1." ], "offsets": [ [ 0, 77 ] ] } ]
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[]
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1.0alpha7.train.445
22779231
[ { "id": "1.0alpha7.train.445.sent", "type": "sentence", "text": [ "Boundary elements that have been well studied in Drosophila include the specialized chromatin sequences (scs and scs՛) flanking the hsp70 genes, Fab-7, Fab-8 and Mcp elements from the Bithorax Complex, and the suppressor of hairy-wing (su(Hw)) binding sites located within the gypsy transposon (reviewed in Bell et al., 2001)." ], "offsets": [ [ 0, 326 ] ] } ]
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[]
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1.0alpha7.train.446
9712292
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[]
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1.0alpha7.train.447
9850644
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[]
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1.0alpha7.train.448
9509122
[ { "id": "1.0alpha7.train.448.sent", "type": "sentence", "text": [ " (C, c) Binding of 125I-Tiam1 fragment to the spectrin binding domain of ankyrin. " ], "offsets": [ [ 0, 85 ] ] } ]
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[]
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1.0alpha7.train.449
16288445
[ { "id": "1.0alpha7.train.449.sent", "type": "sentence", "text": [ "The amphiphysin dimer also binds to clathrin (10, 11) and to the α-adaptin subunit of the plasma membrane clathrin adaptor AP-2 (9, 12) and thus may mediate recruitment of dynamin 1 and synaptojanin 1 to the site of clathrin-mediated endocytosis." ], "offsets": [ [ 0, 246 ] ] } ]
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[]
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1.0alpha7.train.450
13942918
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[]
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1.0alpha7.train.451
25196685
[ { "id": "1.0alpha7.train.451.sent", "type": "sentence", "text": [ "We confirmed using a blot overlay assay that tomosyn directly bound to syntaxin-1a." ], "offsets": [ [ 0, 85 ] ] } ]
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[]
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1.0alpha7.train.452
2077598
[ { "id": "1.0alpha7.train.452.sent", "type": "sentence", "text": [ " Finally, DM stabilizes class II peptide binding sites against inactivation ( 25, 26). " ], "offsets": [ [ 0, 91 ] ] } ]
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[]
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[]
1.0alpha7.train.453
899352
[ { "id": "1.0alpha7.train.453.sent", "type": "sentence", "text": [ "In addition, it was reported that a soluble form of CNTFRα (lacking the glycosylphosphatidylinositol linkage) can bind CNTF and activate gp130-LIFRβ-bearing cells (Taga et al., 1992; Davis et al., 1993b; Robledo et al., 1996)." ], "offsets": [ [ 0, 226 ] ] } ]
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[]
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1.0alpha7.train.454
18858557
[ { "id": "1.0alpha7.train.454.sent", "type": "sentence", "text": [ " Therefore, projectin might not bind CaMKII to serve as its substrate. " ], "offsets": [ [ 0, 74 ] ] } ]
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[]
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1.0alpha7.train.455
9737637
[ { "id": "1.0alpha7.train.455.sent", "type": "sentence", "text": [ "It is not clear at present whether the binding of ERM proteins to CD43 and ICAM-2 (and to as yet unidentified ERM membrane-binding partners) in vivo is also regulated by the Rho signaling pathway." ], "offsets": [ [ 0, 203 ] ] } ]
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[]
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1.0alpha7.train.456
5539444
[ { "id": "1.0alpha7.train.456.sent", "type": "sentence", "text": [ "Oxidative stress stimulates binding of Sp1 and Sp3 to the VEGF-A promoter." ], "offsets": [ [ 0, 78 ] ] } ]
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[]
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1.0alpha7.train.457
15373513
[ { "id": "1.0alpha7.train.457.sent", "type": "sentence", "text": [ "This argues for a function of U2AF35 in addition to assisting U2AF65 binding." ], "offsets": [ [ 0, 79 ] ] } ]
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[]
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[]
1.0alpha7.train.458
25325723
[ { "id": "1.0alpha7.train.458.sent", "type": "sentence", "text": [ " All the fusion proteins that bound to calmodulin contained the N-terminal 32 residues, while those proteins that lacked these residues failed to associate with calmodulin (Figure 2A) . " ], "offsets": [ [ 0, 192 ] ] } ]
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[]
1.0alpha7.train.459
8963181
[ { "id": "1.0alpha7.train.459.sent", "type": "sentence", "text": [ "These observations support a mechanism in which GBP binding to Xgsk-3 prevents substrate phosphorylation." ], "offsets": [ [ 0, 109 ] ] } ]
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[]
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1.0alpha7.train.460
15941453
[ { "id": "1.0alpha7.train.460.sent", "type": "sentence", "text": [ " ( Rho-associated coiled-coil-containing protein kinase) are activated by the GTP-bound form of Rho ( 31, 42, 50). " ], "offsets": [ [ 0, 120 ] ] } ]
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[]
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1.0alpha7.train.461
3392894
[ { "id": "1.0alpha7.train.461.sent", "type": "sentence", "text": [ " Here we report that p202a binds c-Myc in vitro and in vivo, thereby inhibiting the binding of c-Myc to Max, as well as the transcriptional activity of c-Myc. " ], "offsets": [ [ 0, 167 ] ] } ]
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1.0alpha7.train.462
23330713
[ { "id": "1.0alpha7.train.462.sent", "type": "sentence", "text": [ " So far, we have found no evidence that the intramolecular SH3-GK interaction prevents binding of GKAP to the GK domain, but other GK-binding proteins like BEGAIN remain to be examined. " ], "offsets": [ [ 0, 192 ] ] } ]
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[]
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1.0alpha7.train.463
1631394
[ { "id": "1.0alpha7.train.463.sent", "type": "sentence", "text": [ " Two models (Fig. 5) are proposed to explain the phenomenon that once Ku has bound to one DNA molecule, another DNA molecule can only compete for Ku if its ends are complementary to those of the first DNA molecule. " ], "offsets": [ [ 0, 220 ] ] } ]
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[]
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1.0alpha7.train.464
1876014
[ { "id": "1.0alpha7.train.464.sent", "type": "sentence", "text": [ "These proteins are responsible for cadherin binding to the actin cytoskeleton and possibly for intracellular signaling ( 39)." ], "offsets": [ [ 0, 127 ] ] } ]
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[]
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1.0alpha7.train.465
12543870
[ { "id": "1.0alpha7.train.465.sent", "type": "sentence", "text": [ "Mad2 binds and inhibits Cdc20 in vitro (Fang et al. 1998a ; Hwang et al. 1998 ; Kallio et al. 1998 Kim ; et al. 1998 )." ], "offsets": [ [ 0, 125 ] ] } ]
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[]
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1.0alpha7.train.466
24889319
[ { "id": "1.0alpha7.train.466.sent", "type": "sentence", "text": [ "Several proteins have been isolated as putative Rho effectors on the basis of their selective interaction with the GTP-bound form of Rho." ], "offsets": [ [ 0, 140 ] ] } ]
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[]
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1.0alpha7.train.467
19847791
[ { "id": "1.0alpha7.train.467.sent", "type": "sentence", "text": [ " ( C) This PIC binds the Ad origin of DNA replication (the 5' attached TP was omitted for simplification), most likely in a irregular, bent DNA structure. " ], "offsets": [ [ 0, 158 ] ] } ]
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[]
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1.0alpha7.train.468
9631609
[ { "id": "1.0alpha7.train.468.sent", "type": "sentence", "text": [ "Indeed, recent data indicates that Bcl-xL can bind to the mammalian CED-4 homologue Apaf-1, at least under some conditions (Hu et al., 1998; Pan et al., 1998)." ], "offsets": [ [ 0, 159 ] ] } ]
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[]
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1.0alpha7.train.469
4110078
[ { "id": "1.0alpha7.train.469.sent", "type": "sentence", "text": [ "The cadherin-bound form of beta-catenin is anchored at the plasma membrane ( 4)." ], "offsets": [ [ 0, 82 ] ] } ]
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[]
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1.0alpha7.train.470
19227767
[ { "id": "1.0alpha7.train.470.sent", "type": "sentence", "text": [ "The initial steps in formation of the pre-initiation complex - binding of TFIID and TFIIA - are likely to be important determinants of this dynamic equilibrium." ], "offsets": [ [ 0, 160 ] ] } ]
[ { "id": "1.0alpha7.train.470.ent0_0", "type": "protein-complex", "text": [ "pre-initiation complex" ], "offsets": [ [ 38, 60 ] ], "normalized": [] }, { "id": "1.0alpha7.train.470.ent1_0", "type": "protein", "text": [ "TFIIA" ], "offsets": [ [ 84, 89 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2957" }, { "db_name": "hgnc", "db_id": "GTF2A1" }, { "db_name": "uniprot", "db_id": "P52655" } ] }, { "id": "1.0alpha7.train.470.ent2_0", "type": "protein-complex", "text": [ "TFIID" ], "offsets": [ [ 74, 79 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.471
6933611
[ { "id": "1.0alpha7.train.471.sent", "type": "sentence", "text": [ " Although SREBPs are capable of binding E-boxes with high affinity in vitro ( 26, 30), sterol regulation of all carefully examined promoters so far is mediated through SREBP binding to SRE elements and not E-boxes ( 4, 6-10, 27-30). " ], "offsets": [ [ 0, 241 ] ] } ]
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[]
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1.0alpha7.train.472
22630949
[ { "id": "1.0alpha7.train.472.sent", "type": "sentence", "text": [ " At low pH does DM bind to the closed form of MHCII, prying it open, or does DM simply bind to and stabilize the open form of MHCII induced spontaneously by the shift to low pH? " ], "offsets": [ [ 0, 185 ] ] } ]
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[]
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1.0alpha7.train.473
20761608
[ { "id": "1.0alpha7.train.473.sent", "type": "sentence", "text": [ "Although VEGF binds both VEGFR-1 and VEGFR-2, only binding to VEGFR-2 generates mitogenic signal in ECs." ], "offsets": [ [ 0, 104 ] ] } ]
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[]
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1.0alpha7.train.474
2616163
[ { "id": "1.0alpha7.train.474.sent", "type": "sentence", "text": [ " Thus, binding of USF to the DOR promoter sequence is more critical than that of Sp1/Sp3 in NS20Y cells. " ], "offsets": [ [ 0, 110 ] ] } ]
[ { "id": "1.0alpha7.train.474.ent0_0", "type": "protein-family", "text": [ "USF" ], "offsets": [ [ 19, 22 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR024097" } ] }, { "id": "1.0alpha7.train.474.ent1_0", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 84, 87 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.474.ent2_0", "type": "protein", "text": [ "Sp3" ], "offsets": [ [ 88, 91 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6670" }, { "db_name": "hgnc", "db_id": "SP3" }, { "db_name": "uniprot", "db_id": "Q02447" } ] }, { "id": "1.0alpha7.train.474.ent3_0", "type": "cell", "text": [ "NS20Y" ], "offsets": [ [ 96, 101 ] ], "normalized": [] }, { "id": "1.0alpha7.train.474.ent4_0", "type": "DNA", "text": [ "DOR promoter" ], "offsets": [ [ 31, 43 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.475
23310905
[ { "id": "1.0alpha7.train.475.sent", "type": "sentence", "text": [ "In addition to our finding that CYC is present in at least a 200-fold molar excess relative to dCLK in head extracts (see Fig. 4), this contention is supported further by the observations that (1) at all times in a daily cycle essentially all of the dCLK is stably bound to CYC (see Fig. 5A), and (2) the temporal abundance profile of dCLK in immune complexes recovered with anti-CYC antibodies is very similar to that of dCLK present in head extracts (see Fig.3C,D)." ], "offsets": [ [ 0, 467 ] ] } ]
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[]
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