Name,Synonym,CAS RN,Y,Detailed Page,Evidence,OECD TG 404,Data Source,Frequency,SMILES,SMILES URL,SMILES Source,Canonical SMILES,Split "JP_CHRIP: p-Nitrochlorobenzene","JP_CHRIP: p-Chloronitrobenzene 1-Chloro-4-nitrobenzene Benzene, 1-chloro-4-nitro- Chloronitrobenzenes p-Chloronitrobenzene PCNB PNCB",100-00-5,NC,JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-mhlw-2013.html,"JP_CHRIP: 【分類根拠】 （１）、（２）より、区分に該当しない（国連分類基準の区分3）とした。なお、新たな知見に基づき、分類結果を変更した。 【根拠データ】 （１）ウサギ（n= 6）を用いた皮膚刺激性試験（OECD TG 404、GLP、閉塞、24時間適用、8日間観察）において、パッチ除去24及び72時間後の全例の平均スコアは、紅斑ではいずれも0、浮腫では2.17及び1.0であった。48時間値は欠測のため、24時間値と同じと仮定して求めた24/48/72時間の全体の平均スコアは紅斑で0.0、浮腫で1.8であった。本物質は軽微な (slightly) 刺激性を有するとの報告がある（AICIS IMAP (2016)、SIAR (2002)、CERI 有害性評価書 (2008)、REACH登録情報 (Accessed Dec. 2021)）。 （２）ウサギ（n= 6）を用いた皮膚刺激性試験（OECD TG 404、GLP、原体500 mg、24時間閉塞、72時間観察）において、無傷皮膚では紅斑はみられず、軽微な浮腫（フルスコア４：2.17/4）、有傷皮膚では軽微な紅斑（0.17/4）と軽微な浮腫（1.67/4）がみられ、72時間後には消失した。皮膚刺激指数は0.1（最高8）と算出され、本物質は軽微な (slightly) 刺激性を有するとの報告がある（AICIS IMAP (2016)、SIAR (2002)、REACH登録情報 (Accessed Dec. 2021)）。",Provided,JP_CHRIP,1,[O-][N+](=O)c1ccc(Cl)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.586F,J-GLOBAL,O=[N+]([O-])c1ccc(Cl)cc1,Train "NZ_CCID: 4-Methoxybenzoyl chloride","NZ_CCID: p-anisoyl chloride",100-07-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F8EBA1DF-D76D-47F8-B71E-53EFD7A5E5E9,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,COC1=CC=C(C=C1)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7477,PubChem,COc1ccc(C(=O)Cl)cc1,Train "EU_REACH: butyl N-[(butylsulfanyl)methanethioyl]carbamate",,1001320-38-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6482/7/4/2/?documentUUID=b26381a5-2bfb-4410-adef-8d80c8972445,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOC(=O)NC(=S)SCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/87668466,PubChem,CCCCOC(=O)NC(=S)SCCCC,Train "NZ_CCID: 4-Nitrobenzyl chloride",,100-14-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1510B53F-7AAE-42B1-A0B1-7A4B8637026C,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC(=CC=C1CCl)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/7482,PubChem,O=[N+]([O-])c1ccc(CCl)cc1,Train "EU_REACH: (1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31R,32R,33R,34R,35R,36R,37R,38R,39R,40R,41R,42R)-5,10,15,20,25,30-Hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29-dodecaoxahe ptacyclo[26.2.2.23,6.28,11.213,16.218,21.223,26]dotetracontane-31,32,33,34,35,36,37,38,39,40,41,42-dodecol",,10016-20-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10199/7/4/2/?documentUUID=2e64379f-4aa8-4991-be4c-a0e4ca0a4ad6,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C([C@@H]1[C@@H]2[C@@H]([C@H]([C@H](O1)O[C@@H]3[C@H](O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]4[C@H](O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]5[C@H](O[C@@H]([C@@H]([C@H]5O)O)O[C@@H]6[C@H](O[C@@H]([C@@H]([C@H]6O)O)O[C@@H]7[C@H](O[C@H](O2)[C@@H]([C@H]7O)O)CO)CO)CO)CO)CO)O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/444913,PubChem,OC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O[C@H]1[C@H](O)[C@H]2O)O[C@@H]7CO)O[C@@H]6CO)O[C@@H]5CO)O[C@@H]4CO)O[C@@H]3CO,Train "JP_CHRIP: Terephthaloyl dichloride NZ_CCID: Terephthaloyl dichloride","JP_CHRIP: 1.4-benzenedicarbonyl dichloride p-phenylenedicarbonyl dichloride terephthalic acid dichloride terephthalyl dichloride NZ_CCID: terephthaloyl chloride",100-20-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0074e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3415792D-6F89-47E8-B3EB-6F93BCA3F575","JP_CHRIP: The substance was classified in Category 1 because it is described that it is a skin irritant (HSDB (2003)), and there is a description of pH < 0.5 (MSDS (Merck, 2010)). NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,ClC(=O)c1ccc(cc1)C(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.979D,J-GLOBAL,O=C(Cl)c1ccc(C(=O)Cl)cc1,Train "NZ_CCID: Cyclopentylamine",,1003-03-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/25576493-C465-4795-BDD8-E97FB52607E5,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CCC(C1)N,https://pubchem.ncbi.nlm.nih.gov/compound/2906,PubChem,NC1CCCC1,Train "EU_REACH: 1-butoxy-4-[4-(trans-4-ethylcyclohexyl)-1-cyclohexen-1-yl]-2,3-difluorobenzene",,1003218-33-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/28033/7/4/2/?documentUUID=9293756a-8d9d-48f0-9bab-e779b47322a2,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOC1=C(C(=C(C=C1)C2=CCC(CC2)C3CCC(CC3)CC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/147298660,PubChem,CCCCOc1ccc(C2=CCC(C3CCC(CC)CC3)CC2)c(F)c1F,Train "EU_REACH: 4-methyl-1,3-oxazole-5-carbonitrile",,1003-52-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30440/7/4/2/?documentUUID=a056d498-e826-41c0-8f0c-0c3878e29a29,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(OC=N1)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/70480,PubChem,Cc1ncoc1C#N,Train "JP_CHRIP: N,N-Diethylenediamine NZ_CCID: 2-Aminoethyldiethylamine","JP_CHRIP: 1-Amino-2-(N,N-diethylamino)ethane NZ_CCID: N,N-diethylethylenediamine",100-36-7,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0148e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/97B2A5DA-AE60-41B7-9155-AB34A9F616E2","JP_CHRIP: Since a solution of the substance has a pH of 11.6 (20 degC, 10 g/L) (GESTIS (access on Oct. 2009)), the substance was classified into Category 1. NZ_CCID: Skin Irritation UN CLASS: 8; 3; Packing Group II",,"JP_CHRIP, NZ_CCID",2,CCN(CC)CCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J25.753B,J-GLOBAL,CCN(CC)CCN,Train "AU_HCIS: Ethanol, 2-(diethylamino)- JP_CHRIP: Ethanol, 2-(diethylamino)- NZ_CCID: 2-Diethylaminoethanol","AU_HCIS: 2-diethylaminoethanol N,N-diethylethanolamine JP_CHRIP: 2-(Diethylamino)ethanol 2-Diethylaminoethyl alcohol DEAE N,N-Diethylethanolamine NZ_CCID: (2-Hydroxyethyl)diethylamine, 2-(Diethylamino)ethanol, 2-(Diethylamino)ethyl alcohol, 2-(N,N-Diethylamino)ethanol, 2-Hydroxytriethylamine, 2-N-Diethylaminoethanol, DEAE, Diethylamino ethanol, Diethylaminoethanol, Diethylethanolamine, Diethylmonoethanolamine, Ethanol, 2-(diethylamino)-, N,N-Diethyl-2-aminoethanol, N,N-Diethyl-2-hydroxyethylamine, N,N-Diethylethanolamine, N,N-Diethylmonoethanolamine, Pennad 150",100-37-8,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1878 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-2011e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EA912E8C-526D-4362-907D-514458CD8041","JP_CHRIP: In the rabbit test (OECD TG 404), occlusive application of the substance for 3 minutes up to 4 hours caused necrosis and resulted that the substance was corrosive (SIDS (Access on Jun. 2009)). Similarly, in other reports of rabbit tests, necrosis was observed and resulted that the substance was corrosive (SIDS (Access on Jun. 2009)). Based on these test results, the substance was classified as Category 1. As relevant information, the substance was classified as ""R34"" in the EU classification (EU Annex I (2006)). NZ_CCID: Skin Irritation R-PHRASE: R 34 Causes burns. [ECB- Annex - 1] Eye Irritation R-PHRASE: R 34 Causes burns. [ECB- Annex - 1]",Provided,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CCN(CC)CCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.982D,J-GLOBAL,CCN(CC)CCO,Train "EU_REACH: [(6-chloropyridin-3-yl)methyl](2,2-difluoroethyl)amine",,1003859-14-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6647/7/4/2/?documentUUID=3cae490c-6772-46dc-924a-7eefd4d9d659,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=NC=C1CNCC(F)F)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/44604123,PubChem,FC(F)CNCc1ccc(Cl)nc1,Train "EU_REACH: 2-[(4-methyl-2-nitrophenyl)amino]ethan-1-ol",,100418-33-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22442/7/4/2/?documentUUID=a5994755-30cf-4571-b3d8-f238c9372ba2,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)NCCO)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/10130360,PubChem,Cc1ccc(NCCO)c([N+](=O)[O-])c1,Train "NZ_CCID: Benzylamine",,100-46-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CD82B4A8-1C71-4F25-8938-3184B0632B04,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)CN,https://pubchem.ncbi.nlm.nih.gov/compound/7504,PubChem,NCc1ccccc1,Train "NZ_CCID: Phenyl thioxochloroformate","NZ_CCID: o-Phenyl chlorothioformate, phenyl chlorothionoformate",1005-56-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B4CCF7E2-9E9A-41BC-84E8-9D55BF24A78F,"NZ_CCID: Skin Irritation R-PHRASE: R 34. [Company Data] Eye Irritation R-PHRASE: R 34. [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)OC(=S)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/70498,PubChem,S=C(Cl)Oc1ccccc1,Train "NZ_CCID: Cyclohexyl(methyl)amine","NZ_CCID: N-methylcyclohexylamine",100-60-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E393DAB0-EBE1-4010-8ED3-B2B2870B2B31,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CNC1CCCCC1,https://pubchem.ncbi.nlm.nih.gov/compound/7514,PubChem,CNC1CCCCC1,Train "JP_CHRIP: 2-Vinylpyridine NZ_CCID: 2-Vinylpyridine (stabilized with 4-t-butylpyrocatechol)","JP_CHRIP: 2-Vinylpyridine 2-Ethenylpyridine 2-Ethylpyridine 2-Pyridylethylene alpha-Vinylpyridine Pyridine, 2-ethenyl- NZ_CCID: 2-vinylpyridine",100-69-6,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-meti-0008e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3A61356D-51AF-46DA-9905-7A574440768A","JP_CHRIP: There is a report that in a study using rabbits, as a result of the application of 0.5 ml of an undiluted solution of this substance for 1 hour, necrosis was observed (SIDS (2014)). In addition, it is described that this substance caused strong irritation to rabbits (PATTY (6th, 2012)). Moreover, there is a report that this substance caused skin burns after contact with human skin, and the site of inflammation became reddish-brown and took about a month to disappear (Initial Risk Assessment Report (NITE, CERI, NEDO,2005), PATTY (6th, 2012)). From the above, this substance was classified in Category 1. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,C=Cc1ccccn1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J38.336H,J-GLOBAL,C=Cc1ccccn1,Train "JP_CHRIP: N-Ethylmorpholine","JP_CHRIP: Morpholine, 4-ethyl- N-Ethylmorphorine",100-74-3,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2016e.html,"JP_CHRIP: In a skin irritation test with rabbits (equivalent to OECD TG 404), moderate to severe irritation such as erythema and edema were observed 24 hours after application on application of this substance for 1-15 minutes or 20 hours, and necrosis was observed after 8 days on application for 5 minutes or above (SIDS (2007)). Based on this newly added test information, this substance was judged to be corrosive, and it was classified in Category 1B. The category was changed by adding the test information.",Provided,JP_CHRIP,1,CCN1CCOCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.428H,J-GLOBAL,CCN1CCOCC1,Train "JP_CHRIP: Methyl 3-chloro-5-(4,6-dimethoxy-2-pyrimidinylcarbamoylsulfamoyl)-1-methylpyrazole-4-carboxylate; Halosulfuron-methyl",,100784-20-1,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2124e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1), (2). [Evidence Data] (1) In a skin irritation test with rabbits according to OECD TG 404 on this substance, no skin reactions were seen, and it was judged as not a skin irritant (RAC Background Document (2017)). (2) In a skin irritation test with rabbits, no irritation was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014), EU EFSA (2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2008)).",Provided,JP_CHRIP,1,COC(=O)c1c(Cl)nn(C)c1S(=O)(=O)NC(=O)Nc1nc(OC)cc(OC)n1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J640.666A,J-GLOBAL,COC(=O)c1c(Cl)nn(C)c1S(=O)(=O)NC(=O)Nc1nc(OC)cc(OC)n1,Train "EU_REACH: (2,2-dimethyl-1,3-dioxolan-4-yl)methanol",,100-79-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12258/7/4/2/?documentUUID=8dbc09df-a4a0-4e0f-8547-8638bbea689e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(OCC(O1)CO)C,https://pubchem.ncbi.nlm.nih.gov/compound/7528,PubChem,CC1(C)OCC(CO)O1,Train "JP_CHRIP: 1,3,5,7-Tetraazatricyclo[3.3.1.1(3,7)]decane","JP_CHRIP: Methenamine 1,3,5,7-Tetraazatricyclo(3.3.1.1(3,7))decane 1,3,5,7-Tetraazatricyclo[3.3.1.1(3,7)]decane Hexamethylenetetramine Hexamine Methenamine Urotropine",100-97-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-meti-0014e.html,"JP_CHRIP: There is a report that in a skin irritation test (OECD TG404) with rabbits, as a result of an occlusive application of 0.5 mL of this substance for 4 hours, no irritation was observed (EU-RAR (2008), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). On the other hand, irritant dermatitis, redness, edema, etc. were reported in occupational exposure, but reversibility etc. are unknown (EU-RAR (2008)). It is described in EU-RAR (2008) that since this substance is hydrolyzed to form formaldehyde and ammonia on contact with human skin or sweat, irritation observed in occupational exposure may be caused by the decomposition products, formaldehyde and ammonia, there is insufficient evidence to conclude that this substance is irritating (EU-RAR (2008)). From the above, it was classified as ""Not classified"" (Category 3 in UN GHS classification) based on the test compliant with the test guideline.",Provided,JP_CHRIP,1,C1N2CN3CN1CN(C2)C3,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J39.765B,J-GLOBAL,C1N2CN3CN1CN(C2)C3,Train "EU_REACH: 1-[4-({4-[(dimethylcarbamoyl)amino]phenyl}methyl)phenyl]-3,3-dimethylurea",,10097-09-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24294/7/4/2/?documentUUID=bd4a58d8-ad15-46a8-af6e-ff4a6e1c0497,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C)C(=O)NC1=CC=C(C=C1)CC2=CC=C(C=C2)NC(=O)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/305607,PubChem,CN(C)C(=O)Nc1ccc(Cc2ccc(NC(=O)N(C)C)cc2)cc1,Train "EU_REACH: 2,5-bis(phenylamino)benzene-1,4-dicarboxylic acid",,10109-95-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12394/7/4/2/?documentUUID=1c95dd29-c148-43c7-b224-ce6ad09e38e1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)NC2=CC(=C(C=C2C(=O)O)NC3=CC=CC=C3)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/82351,PubChem,O=C(O)c1cc(Nc2ccccc2)c(C(=O)O)cc1Nc1ccccc1,Train "JP_CHRIP: Triallyl cyanurate",,101-37-1,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0177e.html,"JP_CHRIP: The substance was classified as ""Not classified"" based on the document that primary skin irritation index value was 0 and resulted as non irritant in the rabbit test (OECD TG 404) (BUA 248 (2003)).",Provided,JP_CHRIP,1,C=CCOc1nc(OCC=C)nc(OCC=C)n1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J39.663J,J-GLOBAL,C=CCOc1nc(OCC=C)nc(OCC=C)n1,Train "JP_CHRIP: N-({4-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-fluorophenyl}carbamoyl)-2,6-difluorobenzamide; Flufenoxuron",,101463-69-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0081e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 6) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 7-day observation), no irritation changes were seen in any animal (erythema/eschar score: 0/0/0/0/0/0, edema score: 0/0/0/0/0/0) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014), ECHA RAC Opinion (2011), CLH Report (2009), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2015)).",Provided,JP_CHRIP,1,Fc1cc(Oc2ccc(cc2Cl)C(F)(F)F)ccc1NC(=O)NC(=O)c1c(F)cccc1F,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J228.145G,J-GLOBAL,O=C(NC(=O)c1c(F)cccc1F)Nc1ccc(Oc2ccc(C(F)(F)F)cc2Cl)cc1F,Train "NZ_CCID: 1-Propanesulphonyl chloride",,10147-36-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/80F56582-6FF9-4B82-85C7-7A4A786E29E1,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCCS(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/66279,PubChem,CCCS(=O)(=O)Cl,Train "JP_CHRIP: N-Phenyl-1,4-benzenediamine","JP_CHRIP: 4-Aminodiphenylamine N-(4-Aminophenyl)aniline N-Phenyl-p-phenylenediamine",101-54-2,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0025e.html,"JP_CHRIP: In the rabbit test (OECD TG 404) treated with 0.5g of test substance for 4 hours, the average score of erythema and edema were 0 at all observation points, i.e. not irritating (SIDS (2004)). Based on the documents, the substance was classified as ""Not classified"". As relevant information, in volunteers tests, obvious irritation was not observed for 2-hour exposure, but transient irritation was observed in 4-hour exposure in half the people. Obvious erythema was observed for 24-hour exposure, but disappeared in a week (BUA 131 (1993)).",Provided,JP_CHRIP,1,Nc1ccc(Nc2ccccc2)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.017G,J-GLOBAL,Nc1ccc(Nc2ccccc2)cc1,Train "EU_REACH: (3R,3aR,6R,6aR)-6-(3-methoxy-4-{3-methoxy-4-[4-(prop-2-enoyloxy)benzoyloxy]benzoyloxy}benzoyloxy)-hexahydrofuro[3,2-b]furan-3-yl 3-methoxy-4-[4-(prop-2-enoyloxy)benzoyloxy]benzoate; (3R,3aR,6R,6aR)-6-(3-methoxy-4-{4-[4-(prop-2-enoyloxy)benzoyloxy]benzoyloxy}benzoyloxy)-hexahydrofuro[3,2-b]furan-3-yl 3-methoxy-4-[4-(prop-2-enoyloxy)benzoyloxy]benzoate; (3S,3aS,6S,6aS)-6-{3-methoxy-4-[4-(prop-2-enoyloxy)benzoyloxy]benzoyloxy}-hexahydrofuro[3,2-b]furan-3-yl 3-methoxy-4-[4-(prop-2-enoyloxy)benzoyloxy]benzoate",,1015689-48-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1763/7/4/2/?documentUUID=c3feae7f-6d7f-426a-a684-7574a6fa1859,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=C(C=CC(=C1)C(=O)O[C@@H]2CO[C@H]3[C@@H]2OC[C@H]3OC(=O)C4=CC(=C(C=C4)OC(=O)C5=CC=C(C=C5)OC(=O)C=C)OC)OC(=O)C6=CC=C(C=C6)OC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/66690863,PubChem,C=CC(=O)Oc1ccc(C(=O)Oc2ccc(C(=O)O[C@@H]3CO[C@H]4[C@@H]3OC[C@H]4OC(=O)c3ccc(OC(=O)c4ccc(OC(=O)C=C)cc4)c(OC)c3)cc2OC)cc1,Train "EU_REACH: 6-bromo-2-chloro-8-cyclopentyl-5-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one",,1016636-76-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18377/7/4/2/?documentUUID=1f49a80b-df3d-4652-9c66-3dd961d723da,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C(=O)N(C2=NC(=NC=C12)Cl)C3CCCC3)Br,https://pubchem.ncbi.nlm.nih.gov/compound/44248249,PubChem,Cc1c(Br)c(=O)n(C2CCCC2)c2nc(Cl)ncc12,Train "JP_CHRIP: dicyclohexylamine KR_NCIS: Dicyclohexylamine NZ_CCID: Dicyclohexylamine","JP_CHRIP: Dodecahydrodiphenylamine N,N-Dicyclohexylamine N-Cyclohexylcyclohexanamine KR_NCIS: N-Cyclohexylcyclohexanamine; dodecahydrodiphenylamine NZ_CCID: Cyclohexanamine, N-cyclohexyl-",101-83-7,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0028e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F5A530CA-7137-4345-AEC4-1ABD54D8C8C2","JP_CHRIP: In primary skin irritation tests, the substance was topically applied onto 6 rabbits for 24 hours, and during the 21-day observation, the average scores of the Primary Dermal Irritation Index after 24-72 hours indicated that the substance was corrosive (HSDB (2003)). Other tests also reported that the substance was highly corrosive (IUCLID (2000)) or causes immediate necrosis (IUCLID (2000)). Thus, the substance was classified into Category 1. NZ_CCID: Skin Irritation REMARK: EU Classifications (Directive 67/548/EEC): C ?25%: C,N; R22-34-50/53 10% ? C<25%: C,N; R34-51/53 2.5% ? C<10%: Xi,N; R36/38-51/53 2% ? C<2.5%: Xi,; R36/38-52/53 0.25% ? C<2%: R52/53 Eye Irritation REMARK: EU Classifications (Directive 67/548/EEC): C ?25%: C,N; R22-34-50/53 10% ? C<25%: C,N; R34-51/53 2.5% ? C<10%: Xi,N; R36/38-51/53 2% ? C<2.5%: Xi,; R36/38-52/53 0.25% ? C<2%: R52/53",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,C1CCC(CC1)NC1CCCCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.018E,J-GLOBAL,C1CCC(NC2CCCCC2)CC1,Train "NZ_CCID: Dimethyl-N-cyanodithioiminocarbonate",,10191-60-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D4F67168-3584-446E-BCDA-1FB53B5A71B0,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CSC(=NC#N)SC,https://pubchem.ncbi.nlm.nih.gov/compound/66289,PubChem,CSC(=NC#N)SC,Train "EU_REACH: 3-[(2-sulfanylacetyl)oxy]-2,2-bis({[(2-sulfanylacetyl)oxy]methyl})propyl 2-sulfanylacetate",,10193-99-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24985/7/4/2/?documentUUID=c5bb677b-60dd-4a0d-bc90-0eb46ee84a0b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(C(=O)OCC(COC(=O)CS)(COC(=O)CS)COC(=O)CS)S,https://pubchem.ncbi.nlm.nih.gov/compound/82441,PubChem,O=C(CS)OCC(COC(=O)CS)(COC(=O)CS)COC(=O)CS,Train "EU_REACH: 5-[(4-carboxybutanoyl)peroxy]-5-oxopentanoic acid",,10195-54-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23473/7/4/2/?documentUUID=711b4bbb-253e-41b7-8158-6e607ac38f9c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CC(=O)O)CC(=O)OOC(=O)CCCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/44150802,PubChem,O=C(O)CCCC(=O)OOC(=O)CCCC(=O)O,Train "EU_REACH: 3-oxo-N-phenylbutanamide",,102-01-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14590/7/4/2/?documentUUID=3e2a0e7f-dbc5-4f8d-be29-1e80b325a8b5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)CC(=O)NC1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/7592,PubChem,CC(=O)CC(=O)Nc1ccccc1,Train "EU_REACH: 1,3-diphenyl-2-thiourea",,102-08-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11688/7/4/2/?documentUUID=59cb1c86-0977-4bb0-9285-4f37622e5820,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)NC(=S)NC2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/700999,PubChem,S=C(Nc1ccccc1)Nc1ccccc1,Train "JP_CHRIP: Diphenyl carbonate",,102-09-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-0004e.html,"JP_CHRIP: It was classified as ""Not classified"" because there was no irritationin in the result of skin irritation test with rabbits according to OECD TG 404 (SIDS (2006)).",Provided,JP_CHRIP,1,O=C(Oc1ccccc1)Oc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.004K,J-GLOBAL,O=C(Oc1ccccc1)Oc1ccccc1,Train "JP_CHRIP: 3,4-Dichlorophenyl isocyanate",,102-36-3,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0075e.html,"JP_CHRIP: It was classified as ""Not classified"" because it was not irritating in a test by a 4-hour application to the rabbit skin (OECD TG404, GLP-compliant) (IUCLID (2000)), and it was not a primary irritant in another test with rabbits (Federal Hazardous Substance Act, Section 191.11) (IUCLID (2000)).",Provided,JP_CHRIP,1,Clc1ccc(cc1Cl)N=C=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J70.203J,J-GLOBAL,O=C=Nc1ccc(Cl)c(Cl)c1,Train "EU_REACH: 2,5-dimethoxyaniline",,102-56-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5256/7/4/2/?documentUUID=75420e84-12e6-45f4-8403-ae3b7bea0b88,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC(=C(C=C1)OC)N,https://pubchem.ncbi.nlm.nih.gov/compound/7613,PubChem,COc1ccc(OC)c(N)c1,Train "EU_REACH: (1E)-1-chloro-3,3,3-trifluoroprop-1-ene",,102687-65-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10762/7/4/2/?documentUUID=4aaceeee-98e5-4243-9227-d5fdbb852cdb,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(=C/Cl)\C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/5709018,PubChem,FC(F)(F)/C=C/Cl,Train "JP_CHRIP: 2-(Di-n-butylamino)ethanol","JP_CHRIP: 2-(Di-n-butylamino)ethanol 2-(dibutylamino)ethanol 2-(dibutylamino)ethanol (synonym:2-(di-n-butylamino)ethanol) 2-Di-N-butylaminoethyl alcohol N,N-Dibutyl-N-(2-hydroxyethyl)amine N,N-Dibutylethanolamine",102-81-8,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2013e.html,"JP_CHRIP: [Rationale for the Classification] Based on (1)-(3), it was classified in Category 1. [Evidence Data] (1) In an occlusive application test with rabbits for 1 minute, 5 minutes and 20 hours, necrosis was observed after 20 hours and it was judged to be corrosive (REACH registration dossier (Access on July 2019)). (2) It was reported to be corrosive in a test in which 0.01 mL was applied to rabbits for 24 hours (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)). (3) This substance produced necrosis within 24 hours when applied to the skin of rabbits. In addition, when instilled in the eyes, it produced corneal necrosis (ACGIH (7th, 2001)).",,JP_CHRIP,1,CCCCN(CCO)CCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J78.150I,J-GLOBAL,CCCCN(CCO)CCCC,Train "NZ_CCID: 1,3-Propanediamine, N,N-dibutyl-","NZ_CCID: 3-(dibutylamino)propylamine, N,N-Dibutyltrimethylenediamine",102-83-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1488968B-4C6F-4352-80AF-BAF66DCAEBC4,"NZ_CCID: Eye Irritation R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCCCN(CCCC)CCCN,https://pubchem.ncbi.nlm.nih.gov/compound/1626,PubChem,CCCCN(CCCC)CCCN,Train "EU_REACH: 2,5-bis[(4-methylphenyl)amino]benzene-1,4-dicarboxylic acid",,10291-28-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1193/7/4/2/?documentUUID=4a085628-d10d-4a1c-b919-26de70af3ca3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)NC2=CC(=C(C=C2C(=O)O)NC3=CC=C(C=C3)C)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/82524,PubChem,Cc1ccc(Nc2cc(C(=O)O)c(Nc3ccc(C)cc3)cc2C(=O)O)cc1,Train "NZ_CCID: Cinnamoyl chloride",,102-92-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/74852718-6C89-4F9C-976B-70BC0574D6CA,"NZ_CCID: Skin Irritation R PHRASE: R 38 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC=C(C=C1)/C=C/C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/5354261,PubChem,O=C(Cl)/C=C/c1ccccc1,Train "EU_REACH: 2,2-dimethyl-3-oxopropyl dodecanoate",,102985-93-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8619/7/4/2/?documentUUID=872fe893-ed81-4b5e-85ea-acb7079ebadc,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCC(=O)OCC(C)(C)C=O,https://pubchem.ncbi.nlm.nih.gov/compound/23105499,PubChem,CCCCCCCCCCCC(=O)OCC(C)(C)C=O,Train "EU_REACH: 3-(hexyloxy)propane-1,2-diol",,10305-38-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32155/7/4/2/?documentUUID=ec0541ef-8a35-4062-a90f-2edc9ab632f4,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCOCC(CO)O,https://pubchem.ncbi.nlm.nih.gov/compound/11229094,PubChem,CCCCCCOCC(O)CO,Train "EU_REACH: 4a,6a-dimethyl-2-oxo-1H,2H,3H,4H,4aH,4bH,5H,6H,6aH,7H,8H,9H,9aH,9bH,10H-indeno[5,4-f]quinoline-7-carboxylic acid",,103335-54-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6555/7/4/2/?documentUUID=345787bf-319c-4f60-a9b3-72223d48643e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)O)CC=C4[C@@]3(CCC(=O)N4)C,https://pubchem.ncbi.nlm.nih.gov/compound/475447,PubChem,C[C@]12CC[C@H]3[C@@H](CC=C4NC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)O,Train "EU_REACH: tert-butyl 2-[(7R,9R)-9-(cyanomethyl)-6,10-dioxaspiro[4.5]decan-7-yl]acetate",,1035204-82-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10492/7/4/2/?documentUUID=f8433e56-0272-4152-91c0-c1e749bce035,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)OC(=O)C[C@H]1C[C@H](OC2(O1)CCCC2)CC#N,https://pubchem.ncbi.nlm.nih.gov/compound/44249256,PubChem,CC(C)(C)OC(=O)C[C@H]1C[C@@H](CC#N)OC2(CCCC2)O1,Train "EU_REACH: tert-butyl 2-[(7R,9R)-9-{2-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl}-6,10-dioxaspiro[4.5]decan-7-yl]acetate",,1035204-85-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10263/7/4/2/?documentUUID=9ad6daf3-54e5-4d2b-9c2f-9e5df2f38f9e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C1=C(C(=C(N1CC[C@@H]2C[C@@H](OC3(O2)CCCC3)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)F)C5=CC=CC=C5)C(=O)NC6=CC=CC=C6,https://pubchem.ncbi.nlm.nih.gov/compound/44249373,PubChem,CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H]1C[C@H](CC(=O)OC(C)(C)C)OC2(CCCC2)O1,Train "JP_CHRIP: 2-Phenoxyethyl isobutyrate",,103-60-6,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0061e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 8) (equivalent to OECD TG 404, semi-occlusive, 4-hour application, 72-hour observation), slight erythema in 2 animals and slight erythema and edema in 2 were observed after 24 hours, and slight erythema in 1 and slight erythema and edema in 2 persisted after 72 hours (erythema/eschar score: 0/1/0.3/0/0/0/1/1, edema score: 0/0/0/0/0/0/1/1.3) (REACH registration dossier (Accessed Oct. 2020)).",Provided,JP_CHRIP,1,CC(C)C(=O)OCCOc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J182.167I,J-GLOBAL,CC(C)C(=O)OCCOc1ccccc1,Train "JP_CHRIP: (2-Bromoethyl)benzene",,103-63-9,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0194e.html,"JP_CHRIP: The substance was classified as ""Not classified"" based on the document that 24-hour application of 0.5 mL of the undiluted substance to rabbit skin (OECD TG 404, GLP-compliant) did not cause erythema nor edema during the observation period, and the primary skin irritation index value (PII) was 0 (ECETOC 66 (1995)).",Provided,JP_CHRIP,1,BrCCc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J44.198H,J-GLOBAL,BrCCc1ccccc1,Train "NZ_CCID: Phenyl isocyanate",,103-71-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/175F266D-2B3A-4652-8254-B55A79F093A1,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)N=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/7672,PubChem,O=C=Nc1ccccc1,Train "NZ_CCID: Phenylacetyl chloride",,103-80-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7D5F0720-8E56-45E6-89A6-FE826D59A6F2,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)CC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7679,PubChem,O=C(Cl)Cc1ccccc1,Train "JP_CHRIP: benzyldimethylamine NZ_CCID: Benzyldimethylamine","JP_CHRIP: Benzyl-N,N-dimethylamine Dimethylbenzylamine N,N-Dimethylbenzenemethanamine N,N-dimethylbenzylamine N-(Phenylmethyl)dimethylamine N-Benzyldimethylamine NZ_CCID: N,N-dimethylbenzylamine",103-83-3,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0154e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/96BB6924-95D1-488D-9E7C-2C7D0F74F932","JP_CHRIP: Draize tests using rabbits gave score 4 or higher in response to the test substance, indicating that it is severely irritating (ECETOC TR 66 (1995)). Thus, it was classified into Category 1. It is rated as R34 in the EU classification. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CN(C)Cc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J36.099F,J-GLOBAL,CN(C)Cc1ccccc1,Train "JP_CHRIP: Acetanilide",,103-84-4,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0010e.html,"JP_CHRIP: It was classified as ""Not classified"" because it was not irritating in a skin irritation test with rabbits (OECD TG404, GLP-compliant) (SIDS (2001)).",Provided,JP_CHRIP,1,CC(=O)Nc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.023A,J-GLOBAL,CC(=O)Nc1ccccc1,Train "NZ_CCID: Trimethylsilyl N-trimethylsilylacetamidate","NZ_CCID: N,O-Bis(trimethylsilyl) acetamide, bis(trimethylsilyl)acetamide",10416-59-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D6D1FA8E-3CFA-4330-A3BA-CE07F6F83A57,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(=N[Si](C)(C)C)O[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/25248,PubChem,CC(=N[Si](C)(C)C)O[Si](C)(C)C,Train "EU_REACH: dimethyl[2-(4-methylpiperazin-1-yl)ethyl]amine",,104-19-8,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27533/7/4/2/?documentUUID=2e89c95a-ea1b-4b0c-ad29-685dd619899e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN1CCN(CC1)CCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/66908,PubChem,CN(C)CCN1CCN(C)CC1,Train "NZ_CCID: 2-Ethyl-2-oxazoline",,10431-98-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/248ACE75-3954-4A89-95E4-82B749754C01,"NZ_CCID: Skin Irritation R PHRASE: R 35 [Company Data] Effects Below Cut Off Eye Irritation R PHRASE: R 35 [Company Data]",,NZ_CCID,1,CCC1=NCCO1,https://pubchem.ncbi.nlm.nih.gov/compound/66412,PubChem,CCC1=NCCO1,Train "AU_HCIS: Phenol, 4-nonyl- KR_NCIS: Nonylphenols US_HSDB: 4-Nonylphenol","KR_NCIS: 4-Nonylphenol; p-Nonylphenol",104-40-5,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5470 KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/5359",,,"AU_HCIS, KR_NCIS, US_HSDB",3,CCCCCCCCCC1=CC=C(C=C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/1752,PubChem,CCCCCCCCCc1ccc(O)cc1,Train "JP_CHRIP: 2-cyclohexylidene-2-phenylacetonitrile","JP_CHRIP: Cyclohexylidene(phenyl)acetonitrile",10461-98-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0020e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 72-hour observation), no skin irritation was seen (erythema/eschar score: 0/0/0, edema score: 0/0/0) (REACH registration dossier (Accessed Aug. 2020)).",Provided,JP_CHRIP,1,N#CC(=C1CCCCC1)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.470.173E,J-GLOBAL,N#CC(=C1CCCCC1)c1ccccc1,Train "EU_REACH: 2-ethylhexylamine JP_CHRIP: 2-Ethylhexylamine NZ_CCID: 1-Hexanamine, 2-ethyl-","NZ_CCID: 2-Ethylhexylamine",104-75-6,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1994/7/4/2/?documentUUID=8e9eab31-ed59-447a-b936-534c742b0456 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0138e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/63C77C25-D16E-4CC0-8174-08EC7CD96CA2","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: Based on a report that the substance is corrosive solution (PATTY (5th, 2001)), the substance was classified into Category 1. As relevant information, there is a result of ""severe"" irritating in a Draize test with rabbits (24-hour application) (RTECS (1997)). NZ_CCID: Skin Irritation SPECIES: Rabbit RESULT: Severe REFERENCE SOURCE: Prehled Prumyslove Toxikologie; Organicke Latky, Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 (-,436,1986). [RTECS] Eye Irritation SPECIES: Rabbit RESULT: Severe REFERENCE SOURCE: Prehled Prumyslove Toxikologie; Organicke Latky, Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 (-,436,1986). [RTECS]",Provided,"EU_REACH, JP_CHRIP, NZ_CCID",3,CCCCC(CC)CN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J47.019H,J-GLOBAL,CCCCC(CC)CN,Train "EU_REACH: 1-({bis[(1-chloropropan-2-yl)oxy]phosphoryl}oxy)-2-[({bis[(1-chloropropan-2-yl)oxy]phosphoryl}oxy)methyl]-3-chloro-2-(chloromethyl)propane",,1047637-37-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7660/7/4/2/?documentUUID=063917c3-d1a6-4ddb-a0aa-bc09219c83e4,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CCl)OP(=O)(OCC(COP(=O)(OC(C)CCl)OC(C)CCl)(CCl)CCl)OC(C)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/138395011,PubChem,CC(CCl)OP(=O)(OCC(CCl)(CCl)COP(=O)(OC(C)CCl)OC(C)CCl)OC(C)CCl,Train "JP_CHRIP: 3-(Diethylamino)propylamine NZ_CCID: 3-Diethylamino-1-propylamine",,104-78-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0147e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/56A470ED-951E-44BD-85A5-D85DCCE53A67","JP_CHRIP: In a skin irritation test where 0.5 mL of the substance was applied to one rabbit for 4-hour, necrosis was observed 1-hour after application (ECETOC TR66 (1995)). Additionally, the substance has a pH of 11.7 (20 degC, 10 g/L water) (GESTIS (access on Oct. 2009)) and is classified into C; R34 in EU classification. Therefore, the substance was classified into Category 1. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CCN(CC)CCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J35.461I,J-GLOBAL,CCN(CC)CCCN,Train "EU_REACH: (Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-(1,3-benzothiazol-2-ylsulfanyl)-2-oxoethylidene]amino acetate",,104797-47-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25591/7/4/2/?documentUUID=9f7fbca7-4882-47d6-92c2-a057b97c3bd6,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)O/N=C(/C1=CSC(=N1)N)\C(=O)SC2=NC3=CC=CC=C3S2,https://pubchem.ncbi.nlm.nih.gov/compound/11417595,PubChem,CC(=O)O/N=C(\C(=O)Sc1nc2ccccc2s1)c1csc(N)n1,Train "NZ_CCID: Benzenemethanamine, 4-chloro-",,104-86-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3E66A74E-44E0-4388-B209-23CC9C4FD9C7,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC(=CC=C1CN)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/66036,PubChem,NCc1ccc(Cl)cc1,Train "NZ_CCID: Crotonoyl chloride (mixture of cis- and trans isomers)","NZ_CCID: crotonyl chloride",10487-71-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/46B727BC-8505-4B87-8905-84EC7B9CAF41,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C/C=C/C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/643131,PubChem,C/C=C/C(=O)Cl,Train "NZ_CCID: 3-Cyclopentyl propionyl chloride",,104-97-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3B33B989-C9DF-42E6-B4DF-8E6FE2633ACD,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CCC(C1)CCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/66039,PubChem,O=C(Cl)CCC1CCCC1,Train "EU_REACH: cyclohexane-1,4-diyldimethanol",,105-08-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14211/7/4/2/?documentUUID=07fb6645-1229-4b75-9812-3f61256ee806,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC(CCC1CO)CO,https://pubchem.ncbi.nlm.nih.gov/compound/7735,PubChem,OCC1CCC(CO)CC1,Train "EU_REACH: 3-{[4'-(3-aminophenoxy)-[1,1'-biphenyl]-4-yl]oxy}aniline",,105112-76-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1388/7/4/2/?documentUUID=73e9bfac-1b2e-4d5b-867b-8e6706087cd1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC(=C1)OC2=CC=C(C=C2)C3=CC=C(C=C3)OC4=CC=CC(=C4)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/11810717,PubChem,Nc1cccc(Oc2ccc(-c3ccc(Oc4cccc(N)c4)cc3)cc2)c1,Train "NZ_CCID: 3-Methylpentanoic acid","NZ_CCID: 3-methylvaleric acid",105-43-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/97F0DCB2-4890-4531-8142-E30A136DF299,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCC(C)CC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/7755,PubChem,CCC(C)CC(=O)O,Train "EU_REACH: N,N'-ethylenebis[N-acetylacetamide]",,10543-57-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14315/7/4/2/?documentUUID=8104f264-d73d-4696-b31c-35ee1dac4b0f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)N(CCN(C(=O)C)C(=O)C)C(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/66347,PubChem,CC(=O)N(CCN(C(C)=O)C(C)=O)C(C)=O,Train "JP_CHRIP: methyl acetoacetate","JP_CHRIP: Methyl 3-oxobutyrate 1-Methoxybutane-1,3-dione Acetoacetic acid methyl ester Butanoic acid, 3-oxo-, methyl ester methyl acetoacetate",105-45-3,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0155e.html,"JP_CHRIP: Rabbit tests (OECD TG 404, GLP) (IUCLID, 2000) found that the substance is not irritating. Based on this description, it was classified into the ""Not classified"" category.",Provided,JP_CHRIP,1,COC(=O)CC(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J45.957G,J-GLOBAL,COC(=O)CC(C)=O,Train "EU_REACH: 1,3-diethyl-2-thiourea",,105-55-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12736/7/4/2/?documentUUID=54c4520f-e443-4771-b25f-89adf4439c0b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCNC(=S)NCC,https://pubchem.ncbi.nlm.nih.gov/compound/2735009,PubChem,CCNC(=S)NCC,Train "EU_REACH: ethyl 2-cyanoacetate",,105-56-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14515/7/4/2/?documentUUID=e05e38f5-d9d5-4efd-bf56-ae46a1b98cc5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)CC#N,https://pubchem.ncbi.nlm.nih.gov/compound/7764,PubChem,CCOC(=O)CC#N,Train "KR_NCIS: N,N'-Bis(3-aminopropyl)-1,2-ethane diamin","KR_NCIS: 1,3-Propanediamine, N,N''-1,2-ethanediylbis; 1,3-Propanediamine, N,N''-1,2-ethanediylbis-; 1,3-Propanediamine, N,N''-ethylenebis-; 1,3-Propanediamine, N1,N1'-1,2-ethanediylbis-; N-(2-(3-Aminopropylamino)ethyl)-1,3-propanediamine; N,N'-Bis(3-aminopropyl)-1,2-ethanediamine; N,N'-Bis(3-aminopropyl)diaminoethane; N,N'-Bis(3-aminopropyl)ethylenediamine; N,N'-Diaminopropylethylenediamine; N-[2-(3-Aminopropylamino)ethyl]propane-1,3-diamine",10563-26-5,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C(CN)CNCCNCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/25378,PubChem,NCCCNCCNCCCN,Train "EU_REACH: {3-[(3-aminopropyl)amino]propyl}dimethylamine",,10563-29-8,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12651/7/4/2/?documentUUID=eefcc885-0e68-4f02-a55d-c6eade158cf9,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C)CCCNCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/82728,PubChem,CN(C)CCCNCCCN,Train "JP_CHRIP: 2,4-Xylenol KR_NCIS: 2,4-Dimethylphenol NZ_CCID: 2,4-Xylenol","JP_CHRIP: 2,4-Xylenol Phenol, 2,4-dimethyl- KR_NCIS: 1-Hydroxy-2,4-dimethylbenzene; 2,4-Xylenol; 4,6-Dimethylphenol; 4-Hydroxy-1,3-dimethylbenzene; m-Xylenol; Phenol, 2,4-dimethyl- NZ_CCID: 1-Hydroxy-2,4-dimethylbenzene, Phenol, 2,4-dimethyl-, m-Xylenol",105-67-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-meti-0025e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1482CCF7-1FF3-4030-A317-B48A7FF08DC5","JP_CHRIP: Because it is reported that in a skin irritation test with rabbits, corrosive action was observed on application of this substance (EPA Pesticide RED (1994)), and it is described in multiple pieces of literature that this substance is corrosive to the skin (Environmental Risk Assessment for Chemical Substances Vol.5 (Ministry of the Environment, 2006), EPA Pesticide Fact Sheet (1994)), the substance was classified in Category 1. In addition, this substance was classified as ""Skin. Corr. 1B H314"" in the EU CLP classification (ECHA CL Inventory (Access on October 2015)). NZ_CCID: Skin Irritation R-PHRASE: R 34 Causes burns. [N-CLASS] Eye Irritation EXPERT JUDGEMENT: Assume it will be as corrosive to eyes as it is corrosive to skin.",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,Cc1ccc(O)c(C)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.606D,J-GLOBAL,Cc1ccc(O)c(C)c1,Train "EU_REACH: dodecanoyl dodecaneperoxoate JP_CHRIP: dilauroyl peroxide","JP_CHRIP: bis(1-Oxododecyl)peroxide didodecanoyl peroxide Lauroyl peroxide Peroxide, bis(1-oxododecyl) Peroxide, didodecanoyl",105-74-8,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2224/7/4/2/?documentUUID=b567389c-23c7-4a9f-9b72-98962fb7ee46 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0156e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: Since rabbit tests found that the substance causes no irritation (DFGOT vol. 3 (1992)), it was classified into the ""Not classified"" category.",Provided,"EU_REACH, JP_CHRIP",2,CCCCCCCCCCCC(=O)OOC(=O)CCCCCCCCCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.853C,J-GLOBAL,CCCCCCCCCCCC(=O)OOC(=O)CCCCCCCCCCC,Train "EU_REACH: dibutyl but-2-enedioate",,105-75-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2056/7/4/2/?documentUUID=d48e8f07-c579-49cd-8ee4-64fc4828e864,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOC(=O)/C=C/C(=O)OCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/5271570,PubChem,CCCCOC(=O)/C=C/C(=O)OCCCC,Train "JP_CHRIP: 1-(6-Chloro-3-pyridylmethyl)-N-nitroimidazolidin-2-ylidenamine; Imidacloprid",,105827-78-9,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2074e.html,"JP_CHRIP: [Rationale for the Classification] Based on (1), it was classified as ""Not classified."" [Evidence Data] (1) The mean scores at 24/48/72 hours were all 0 in a skin irritation test with rabbits according to OECD TG 404, and it was concluded to be non-irritating (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2013), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2016)).",Provided,JP_CHRIP,1,[O-][N+](=O)N=C1NCCN1Cc1ccc(Cl)nc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J452.024F,J-GLOBAL,O=[N+]([O-])N=C1NCCN1Cc1ccc(Cl)nc1,Train "NZ_CCID: 1,3-Propanediamine, N-(3-aminopropyl)-N-methyl-","NZ_CCID: N,N-Bis(3-aminopropyl) methylamine",105-83-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EB33CDC0-B5F4-49D8-BBA7-7F0A09C8FE22,"NZ_CCID: Skin Irritation R PHRASE: R 34 [ECB] Eye Irritation R PHRASE: R 34 [ECB]",,NZ_CCID,1,CN(CCCN)CCCN,https://pubchem.ncbi.nlm.nih.gov/compound/7777,PubChem,CN(CCCN)CCCN,Train "EU_REACH: 2-phenoxyethyl methacrylate",,10595-06-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21714/7/4/2/?documentUUID=c0f6ce93-ace5-4a47-a9ea-ab8c9cf633dc,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OCCOC1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/66357,PubChem,C=C(C)C(=O)OCCOc1ccccc1,Train "EU_REACH: 1,4-dioxacycloheptadecane-5,17-dione",,105-95-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14715/7/4/2/?documentUUID=34a46e3c-ed96-4d8f-a5d9-15902b4451fd,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CCCCCC(=O)OCCOC(=O)CCCCC1,https://pubchem.ncbi.nlm.nih.gov/compound/61014,PubChem,O=C1CCCCCCCCCCCC(=O)OCCO1,Train "EU_REACH: 1-oxacyclohexadecan-2-one",,106-02-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5937/7/4/2/?documentUUID=c7079faa-1c96-4f65-a564-eb79b91dcbb9,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CCCCCCCOC(=O)CCCCCC1,https://pubchem.ncbi.nlm.nih.gov/compound/235414,PubChem,O=C1CCCCCCCCCCCCCCO1,Train "EU_REACH: carbendazim JP_CHRIP: carbendazim(ISO)","JP_CHRIP: 1H-Benzimidazol-2-ylcarbamic acid methyl ester 1H-Benzimidazole-2-carbamic acid, methyl ester 2-methoxycarbonylamino-benzimidazole Carbamic acid, 1H-benzimidazol-2-yl-, methyl ester Carbendazim Carbendazol Methyl (1H-benzimidazol-2-yl)carbamate methyl benzimidazole-2-yl-carbamate Methyl benzimidazole-2-ylcarbamate",10605-21-7,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27856/7/4/2/?documentUUID=48616375-3c22-4a1f-b4ca-26f7a4d9aae2 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/07-meti-0015e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: Since EHC149 (1993) states, ""There is no skin irritation, because no irritation was observed in all of the 4 hour applications of 2.5g to rabbits in 4, 24, 48 and 72 hours,"" it was classified into ""Not classified"".",Provided,"EU_REACH, JP_CHRIP",2,COC(=O)Nc1nc2ccccc2[nH]1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.120H,J-GLOBAL,COC(=O)Nc1nc2ccccc2[nH]1,Train "KR_NCIS: Bis(2-ethylhexyl)amine NZ_CCID: Bis(2-ethylhexyl) amine","KR_NCIS: 1-Hexanamine, 2-ethyl-N-(2-ethylhexyl)-; 2,2'-Diethyldihexylamine; 2-Ethyl-N-(2-ethylhexyl)hexan-1-amine; Bis(2-ethylhexyl)amine; Di(2-ethylhexyl)amine; Di-(2-Ethylhexyl)-amine; Di-2-ethylhexylamine; Dihexylamine, 2,2'-diethyl-; N,N-Bis(2-ethylhexyl)amine NZ_CCID: bis(2-ethylhexyl)amine",106-20-7,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2044B219-353C-469E-AC08-3CB6CA325CB3","NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"KR_NCIS, NZ_CCID",2,CCCCC(CC)CNCC(CC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/7791,PubChem,CCCCC(CC)CNCC(CC)CCCC,Train "JP_CHRIP: Butyric anhydride NZ_CCID: Butyric anhydride",,106-31-0,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0160e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/379EB139-75D2-4CD4-A5C4-83F2450146C8","JP_CHRIP: It was described in the human case that the substance caused skin irritation by contact with vapor (HSDB (2002)). And as for the information of n-butyric acid it was reported that in the guinea pig test (occlusive application with 10mg for 24 hours, non-occlusive application with 500mg for 24 hours), severe reactions were observed (PATTY, 5th (2001)). And it was also reported that in the rabbit test (OECD TG404, GLP-compliant), corrosive effects were observed (IUCLID (2000)). Based on these documents, the substance was classified as Category 1. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",Provided,"JP_CHRIP, NZ_CCID",2,CCCC(=O)OC(=O)CCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.050D,J-GLOBAL,CCCC(=O)OC(=O)CCC,Train "EU_REACH: 2,4,8,10-tetra(tert-butyl)-6-hydoroxy-12H-dibenzo[d,g] [1,3,2]dioxaphosphocin, 6-oxide",,106396-29-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/28016/7/4/2/?documentUUID=10b98ccc-93b5-4e4a-ba2c-1bb2e1a9cfad,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1=CC2=C(C(=C1)C(C)(C)C)OP(=O)(OC3=C(C2)C=C(C=C3C(C)(C)C)C(C)(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/174427,PubChem,CC(C)(C)c1cc2c(c(C(C)(C)C)c1)OP(=O)(O)Oc1c(cc(C(C)(C)C)cc1C(C)(C)C)C2,Train "AU_HCIS: p-cresol [1] JP_CHRIP: p-Cresol KR_NCIS: 4-Methylphenol NZ_CCID: 4-Cresol US_HSDB: p-CRESOL","AU_HCIS: o-cresol [2] p-cresol [3] mix-cresol [4] Phenol, 4-methyl- p-cresol o-cresol mix-cresol JP_CHRIP: 4-Hydroxy-1-methylbenzene 4-Methylphenol cresol p-cresol p-Cresol; 4-Methylphenol para-Hydroxytoluene Phenol, 4-methyl- KR_NCIS: 1-Hydroxy-4-methylbenzene; 1-Methyl-4-hydroxybenzene; 4-Cresol; 4-Hydroxy-1-methylbenzene; 4-Hydroxytoluene; CRESOL, P-; p-Cresol; p-Hydroxytoluene NZ_CCID: p-Cresol",106-44-5,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1068 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2033e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9E52F8E5-0163-4C72-9E07-F0EF50369828 US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1814","JP_CHRIP: There is a report that after occlusive application of 0.5 mL of the undiluted liquid of this substance for 4 hours to rabbits, corrosivity (2/6 animals) was observed (EHC 168 (1995), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), SIDS (2005)). In another study, there is a report that after application of the undiluted liquid of this substance to rabbits, severe erythema and edema occurred within 24 hours and did not disappear within 72 hours (SIDS (2001)). From the above results, it was classified in Category 1. Besides, this substance was classified in ""C; R34"" in EU DSD classification and in ""Skin Corr. 1B"" in EU CLP classification. NZ_CCID: Skin Irritation R PHRASE: R 38 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,Cc1ccc(O)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.185A,J-GLOBAL,Cc1ccc(O)cc1,Train "JP_CHRIP: 4-chlorophenol","JP_CHRIP: 4-Chloro-1-hydroxybenzene 4-Chlorophenol 4-Hydroxychlorobenzene 4-Monochlorophenol p-Chlorophenol",106-48-9,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0031e.html,"JP_CHRIP: Since the substance was corrosive in topical application tests using rabbits (ATSDR (1999)), it was classified into Category 1.",,JP_CHRIP,1,Oc1ccc(Cl)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.611K,J-GLOBAL,Oc1ccc(Cl)cc1,Train "EU_REACH: N-(4-{[3-(dimethylamino)propyl]sulfamoyl}phenyl)-2-[(2-methoxy-4-nitrophenyl)diazenyl]-3-oxobutanamide",,1065519-44-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1176/7/4/2/?documentUUID=09306093-c9df-4f98-8c9b-ca7830cd14db,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC=C(C=C1)S(=O)(=O)NCCCN(C)C)N=NC2=C(C=C(C=C2)[N+](=O)[O-])OC,https://pubchem.ncbi.nlm.nih.gov/compound/91997932,PubChem,COc1cc([N+](=O)[O-])ccc1N=NC(C(C)=O)C(=O)Nc1ccc(S(=O)(=O)NCCCN(C)C)cc1,Train "NZ_CCID: 1,4-Dimethylpiperazine",,106-58-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/37A2C430-87EF-450C-9EBF-C93A919797BE,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CN1CCN(CC1)C,https://pubchem.ncbi.nlm.nih.gov/compound/7818,PubChem,CN1CCN(C)CC1,Train "EU_REACH: dimethyl succinate JP_CHRIP: Dimethyl succinate",,106-65-0,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15043/7/4/2/?documentUUID=c01039dd-200a-4016-9398-0745284d5d44 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0077e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: It was classified as ""Not classified"" because the average irritation score was 0.0 in a test by a 4-hour application to the skin of six rabbits (EPA 40CFR 798.4470, GLP), and there was no irritation (USEPA/HPV (2001)).",Provided,"EU_REACH, JP_CHRIP",2,COC(=O)CCC(=O)OC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.244A,J-GLOBAL,COC(=O)CCC(=O)OC,Train "EU_REACH: methyl hexanoate",,106-70-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5296/7/4/2/?documentUUID=38d53c6f-1ac0-48f8-9589-f03562963f60,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCC(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/7824,PubChem,CCCCCC(=O)OC,Train "EU_REACH: ethenyl-tris(2-methoxyethoxy)silane",,1067-53-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14177/7/4/2/?documentUUID=7bb0a8d1-2375-4804-8be9-a466e98ad1af,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COCCO[Si](C=C)(OCCOC)OCCOC,https://pubchem.ncbi.nlm.nih.gov/compound/14025,PubChem,C=C[Si](OCCOC)(OCCOC)OCCOC,Train "EU_REACH: 2-{2-[(2-chloroacetyl)oxy]ethoxy}ethyl 2-chloroacetate",,106-78-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26885/7/4/2/?documentUUID=a0b4551c-c1af-4ec9-8fbf-2d07cb9d96a4,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(COC(=O)CCl)OCCOC(=O)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/15376062,PubChem,O=C(CCl)OCCOCCOC(=O)CCl,Train "AU_HCIS: Oxirane, (chloromethyl)- JP_CHRIP: Epichlorohydrin KR_NCIS: Epichlorohydrin NZ_CCID: Oxirane, (chloromethyl)-","AU_HCIS: 1-chloro-2,3-epoxypropane epichlorhydrin JP_CHRIP: 1-Chloro-2,3-epoxypropane .alpha.-Epichlorohydrin 1,2-Epoxy-3-chloropropane 1-chloro-2,3-epoxypropane 2-Chloropropylene oxide Epichlorohydrin gamma-Chloropropylene oxide KR_NCIS: 1-Chloro-2,3-epoxypropane NZ_CCID: (Chloromethyl) ethylene oxide, 1,2-Epoxy-3-chloropropane, 1-Chloro-2,3-epoxypropane, 2,3-Epoxypropyl chloride, 2-(Chloromethyl) oxirane, 3-Chloro-1,2-epoxypropane, 3-Chloro-1,2-propylene oxide, 3-Chloropropene-1,2-oxide, 3-Chloropropylene oxide, Chloromethyloxirane, Chloropropylene oxide, Epichlorhydrin, Epichlorohydrin, Glycerol epichlorhydrin, Glycerol epichlorohydrin, Glycidyl chloride, Propane, 1-chloro-2,3-epoxy-",106-89-8,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3325 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-2073e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E4B8D5F2-D32E-4D09-92E3-873F726B1F4B","JP_CHRIP: In a rabbit skin irritation test, in which a stock solution of the substance was applied for 2 - 24-hour, severe irritation and necrosis were observed (Hazard Assessment Report (CERI, NITE) No. 74 (2004)). In accidental cases of occupational exposure, effects such as skin ulcer, erosion and burns are reported (Hazard Assessment Report (CERI, NITE) No. 74 (2004), ACGIH (7th, 2001)). The substance is classified into C; R34 in EU classification. Based on these information, the substance was classified into Category 1. NZ_CCID: Skin Irritation SPECIES: Rabbit RESULT: Highly irritating REFERENCE SOURCE: Shell Nederland Chemie B.V. Hoogvliet-Rotterdam (74)(74) Pallade S., Dorobantu M., Gabrielescu E. (1967), ""Etude experimentale de lintoxication par lepichlorhydrine"", Arch. Mal. Prof. Med. Trav., 28, 505-16. [IUCLID 2000] REMARK: EC Classification = Corrosive (causes burns). Eye Irritation SPECIES: Rabbit RESULT: Corrosive REFERENCE SOURCE: Shell Nederland Chemie B.V. Hoogvliet-Rotterdam (76)(76) Weil C.S., Condra N., Haun C., Striegel J.A. (1963), ""Experimental carcinogenicity and acute toxicity of representative epoxides"", Am. Ind. Hyg. Ass. J., 24, 305-25. [IUCLID 2000]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID",4,ClCC1CO1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.037A,J-GLOBAL,ClCC1CO1,Train "KR_NCIS: Glycidyl acrylate","KR_NCIS: 2,3-Epoxypropyl acrylate; 2-Propenoic acid, 2-oxiranylmethyl ester; Acrylic acid, 2,3-epoxypropyl ester; Acrylic acid, glycidyl ester; Epoxypropyl acrylate; Glycidyl acrylate; Glycidyl propenate; Oxiran-2-ylmethyl prop-2-enoate",106-90-1,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C=CC(=O)OCC1CO1,https://pubchem.ncbi.nlm.nih.gov/compound/7836,PubChem,C=CC(=O)OCC1CO1,Train "NZ_CCID: 2,5-Pyrrolidinedione, 3-dodecyl-1-(1,2,2,6,6-pentamethyl-4-piperidinyl)-",,106917-30-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DAEDE003-0744-42F3-90BA-2DEA8747D602,"NZ_CCID: Skin Irritation SPECIES: RESULT: The material may cause Skin Irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the production of vesicles, scaling and thickening of the skin. REFERENCE SOURCE: [CHEMWATCH] REMARK: UN 2922 class 8 PG III Eye Irritation SPECIES: RESULT: The material may be irritating to the eye, with prolonged contact causing inflammation. Repeated or prolonged exposure to irritants may produce conjunctivitis. REFERENCE SOURCE: [CHEMWATCH] R-PHRASE: R 35 Causes severe burns. [ECB - Annex 1]",,NZ_CCID,1,CCCCCCCCCCCCC1CC(=O)N(C1=O)C2CC(N(C(C2)(C)C)C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/86098,PubChem,CCCCCCCCCCCCC1CC(=O)N(C2CC(C)(C)N(C)C(C)(C)C2)C1=O,Train "NZ_CCID: Piperidine, 1-acetyl-4-(3-dodecyl-2,5-dioxo-1-pyrrolidinyl)-2,2,6,6-tetramethyl-",,106917-31-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3E5DFD7A-7EF8-445D-9C6B-1123419FB72D,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCCCCCCCCCCCC1CC(=O)N(C1=O)C2CC(N(C(C2)(C)C)C(=O)C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/3034263,PubChem,CCCCCCCCCCCCC1CC(=O)N(C2CC(C)(C)N(C(C)=O)C(C)(C)C2)C1=O,Train "JP_CHRIP: 3-Bromo-1-propene KR_NCIS: 3-Bromo-1-propene NZ_CCID: 3-Bromo-1-propene","JP_CHRIP: Allyl bromide Allyl bromide 3-Bromo-1-propene 3-bromoprop-1-ene (synonym:3-bromo-1-propene or allyl bromide) NZ_CCID: allyl bromide",106-95-6,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0023e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/08B655B6-01A6-4606-BCD8-39F3698BA99C","JP_CHRIP: In a skin irritation test using mice, after application of 0.5 mL of this substance (99%) for 3 minutes or 4 hours, erythema and edema were observed after 3-minute application, and erythema did not resolve during an observation period (7 days). A 4-hour application group showed erythema and edema which did not resolve during an observation period, and one animal showed tissue destruction and was killed (ECETOC TR66 (1995)). Besides, it is written that this substance is severely irritating to skin (HSDB (Access on June 2015)). From the above results, it was judged to be classified in Category 1. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,BrCC=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.040A,J-GLOBAL,C=CCBr,Train "NZ_CCID: 2-Ethylhexyl dihydrogen phosphate","NZ_CCID: Phosphoric acid, mono(2-ethylhexyl)ester",1070-03-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A3281E22-D4D1-4A1F-96F3-9985FD308231,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCCCC(CC)COP(=O)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/14050,PubChem,CCCCC(CC)COP(=O)(O)O,Train "JP_CHRIP: Acrylaldehyde KR_NCIS: Acrolein NZ_CCID: Acrolein US_HSDB: ACROLEIN","JP_CHRIP: 2-Propen-1-al 2-Propenal Acrolein acrolein (synonym:acrylaldehyde) acrylaldehyde (synonym:acrolein) Acrylic aldehyde Prop-2-enal KR_NCIS: 2-Propenal NZ_CCID: 2-Propenal, Acraldehyde, Acrylaldehyde, Acrylic aldehyde, Allyl aldehyde, Aqualin, Ethylene aldehyde, Prop-2-en-1-al",107-02-8,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2004.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/891B07E1-8729-43BF-B83A-41008FE6788B US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/177","JP_CHRIP: 【分類根拠】 （１）、（２）より、区分1とした。 【根拠データ】 （１）本物質0.01～10％溶液をボランティアの皮膚に適用したパッチテストにおいて、0.01％溶液を適用した8名及び0.1％溶液を適用した10名では陽性反応はみられなかった。1％溶液を適用した48名では12.5％（6/48名）が陽性反応を示し、うち4名で水疱形成を伴う重度の浮腫、2名で紅斑と重度浮腫がみられた。10％溶液では全例（20/20名）の皮膚に水疱、壊死、炎症細胞の浸潤、乳頭状の水腫がみられたとの報告がある（NITE 初期 リスク評価書 (2007)、ECHA RAC Opinion (2012)、CLH Report (2011)、EU RAR (2001)、ATSDR (2007)、AICIS IMAP (2017)、CICAD (2002)、CEPA PSAR (2000)、REACH登録情報（Accessed Juｌｙ 2021)）。 （２）ウサギ（n=6）を用いた皮膚刺激性試験（14日観察）において、試験期間中に死亡（原因不明）した2例を除いた4例の24/72h後の紅斑スコアの平均は1、浮腫スコアの平均は3であり、3例でみられた影響は14日以内に回復しなかったとの報告がある（ECHA RAC Opinion (2012)、CLH Reoort (2011)、AICIS IMAP (2017)）。 【参考データ等】 （３）本物質は、平成8年労働省告示第33号（平成25年厚生労働省告示第316号により改正）において、労働基準法施行規則別表第一の二第四号1の厚生労働大臣が指定する単体たる化学物質及び化合物（合金を含む。）に「アクロレイン」として指定されており、本物質にさらされる業務による、特定の症状又は障害を主たる症状又は障害とする疾病（皮膚障害、前眼部障害又は気道・肺障害）が、業務上の疾病として定められている。 NZ_CCID: Skin Irritation R PHRASE: R 34 [ECB] Eye Irritation R PHRASE: R 34 [ECB]",,"JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",4,C=CC=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.045B,J-GLOBAL,C=CC=O,Train "EU_REACH: 4-({6-chloro-2-[(4-cyanophenyl)amino]pyrimidin-4-yl}oxy)-3,5-dimethylbenzonitrile",,1070377-34-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25836/7/4/2/?documentUUID=a53cfa2c-052b-454b-b56b-9105893c8cf7,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=CC(=C1OC2=CC(=NC(=N2)NC3=CC=C(C=C3)C#N)Cl)C)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/50914946,PubChem,Cc1cc(C#N)cc(C)c1Oc1cc(Cl)nc(Nc2ccc(C#N)cc2)n1,Train "EU_REACH: ethyl 6,8-dichlorooctanoate",,1070-64-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31429/7/4/2/?documentUUID=f951c697-40c9-420a-abc9-853d27afa43c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)CCCCC(CCCl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/14053,PubChem,CCOC(=O)CCCCC(Cl)CCCl,Train "NZ_CCID: 1,4-Butanediol diacrylate",,1070-70-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A1F7A1E7-05D3-4A6B-80EA-FDE3BDD1D11A,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C=CC(=O)OCCCCOC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/70613,PubChem,C=CC(=O)OCCCCOC(=O)C=C,Train "NZ_CCID: 3,3-Dimethylbutyric acid",,1070-83-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2844A019-798A-44CB-A2BF-E83D5F4C2D18,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CC(C)(C)CC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/14057,PubChem,CC(C)(C)CC(=O)O,Train "JP_CHRIP: Propylamine NZ_CCID: 1-Propanamine","JP_CHRIP: 1-Aminopropane n-Propylamine Propanamine NZ_CCID: 1-Aminopropane, Monopropylamine, Propylamine",107-10-8,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0047e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EA72A93B-D31E-4C3F-B537-DF250ECC1B3A","JP_CHRIP: Based on a report of grade 6 (maximum grade 8) in rabbit test (PATTY (5th, 2001)), a report of ""contact can severely irritate and burn the skin"" (HSFS (2001)), and information of pH 12.6 (20 degC, 100 g/L) (GESTIS (access on Aug. 2009)), the substance was classified into Category 1. As relevant information, another report is noted ""irritating to skin, eyes, and respiratory system in human"" (HSDB (2008)). NZ_CCID: Skin Irritation SPECIES: Guinea pig RESULT: Severe REFERENCE SOURCE: [Peer Reviewed] [Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963. 2053] HSDB. UN CLASS: 8 PG II Eye Irritation SPECIES: Rabbit RESULT: Severe. Graded 9 on a scale of 1 to 10. REFERENCE SOURCE: Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986. 768]**PEER REVIEWED** [HSDB] UN CLASS: 8 PG II",,"JP_CHRIP, NZ_CCID",2,CCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.052E,J-GLOBAL,CCCN,Train "JP_CHRIP: 3-Amino-1-propene; Allylamine","JP_CHRIP: 2-Propenylamine 3-Aminopropene monoallylamine",107-11-9,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2018e.html,"JP_CHRIP: [Rationale for the Classification] Based on (1), it was classified in Category 1. Besides, since new data were obtained, the category was changed. [Evidence Data] (1) In an in vitro skin corrosion test using an artificial skin model (EpiDerm) in accordance with OECD TG 431, after 3 or 60 minutes of exposure, the viability was 12.8% or 8.4%, respectively (REACH registration dossier (Access on July 2019)). [Reference Data, etc.] (2) This substance is a severe eye and skin irritant (PATTY (6th, 2012)). (3) This substance is a severe skin and eye irritant in humans (HSDB (Access on June 2019)).",,JP_CHRIP,1,NCC=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.053C,J-GLOBAL,C=CCN,Train "NZ_CCID: Phosphorylethanolamine","NZ_CCID: 2-Aminoethyl dihydrogen phosphate, Colamine phosphate, Ethanol, 2-amino-, phosphate, Ethanolamine O-phosphate, Ethanolamine phosphate, Mono(2-aminoethyl) phosphate, O-Phosphoethanolamine, O-Phosphorylethanolamine, Phosphoethanolamine, Phosphonoethanolamine, Phosphoric acid, 2-aminoethyl phenyl ester, Phosphoryethanolamine, Ethanol, 2-amino-, dihydrogen phosphate (ester)",1071-23-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CA18F847-CF01-40E1-82B5-58941D64F351,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Chemwatch] Eye Irritation R PHRASE: R 41 [Chemwatch]",,NZ_CCID,1,C(COP(=O)(O)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/1015,PubChem,NCCOP(=O)(O)O,Train "JP_CHRIP: Ethylenediamine KR_NCIS: 1,2-Ethanediamine; Ethylenediamine NZ_CCID: Ethylenediamine","JP_CHRIP: 1,2-Diaminoehtane 1,2-Diaminoethane 1,2-Ethanediamine 1,2-Ethylenediamine Dimethylenediamine Ethane-1,2-diamine Ethylene diamine NZ_CCID: 1,2-Diaminoethane, 1,2-Ethanediamine, 1,2-Ethylenediamine, Dimethylenediamine, Ethylendiamine",107-15-3,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-2020e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F417F0FB-94DF-4EFF-8B2B-07BA946DB39C","JP_CHRIP: It is described that in a test in which undiluted this substance was applied to rabbits for 1 minute, there were severe inflammation and necrosis at the application site, and some animals had scars that reached the muscle (Initial Risk Assessment Report Ver.1.0, 55 (NITE, CERI, NEDO, 2007)), and in a test by 24-hour occlusive application of the undiluted this substance to rats, necrosis that reached the deep skin occurred and was still seen after 14 days (Initial Risk Assessment Report Ver.1.0, 55 (NITE, CERI, NEDO, 2007)). Therefore, it was classified in Category 1. Besides, pH was 11.8 (5 g/L aqueous solution) (SIDS (2001)). NZ_CCID: Skin Irritation R-PHRASE: R 34. [N-CLASS] UN CLASS 8, PG II. Eye Irritation SPECIES: RESULT: Corrosive REFERENCE SOURCE: Union Carbide Benelux Antwerpen (91) [IUCLID] REMARK: EC Classification: Risk of serious damage to eyes. R-PHRASE: R 34.[N-CLASS]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,NCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.057F,J-GLOBAL,NCCN,Train "JP_CHRIP: N-(phosphonomethyl)glycine [glyphosate]","JP_CHRIP: Glycine, N-(phosphonomethyl)- Glyphosate N-(Phosphonomethyl)glycine",1071-83-6,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0095e.html,"JP_CHRIP: It is reported that in a test using rabbits (US EPA guidelines or OECD TG 404, GLP), slight irritation was observed and the score is 0.8. It is reported that in 4 other tests using rabbits (US EPA guidelines or OECD TG 404, GLP), no irritation was observed in any of these tests (EHC 159 (1994), JMPR (2004)). Therefore, this substance was classified as ""Not classified.""",Provided,JP_CHRIP,1,OC(=O)CNCP(=O)(O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.359F,J-GLOBAL,O=C(O)CNCP(=O)(O)O,Train "JP_CHRIP: Hexanedioic acid, 1,6-dihydrazide","JP_CHRIP: adipic dihydrazide adipohydrazide Hexanedioic acid, dihydrazide",1071-93-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0019e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 72-hour observation), no skin irritation was seen (erythema/eschar score: 0/0/0, edema score: 0/0/0) (REACH registration dossier (Accessed Aug. 2020)).",Provided,JP_CHRIP,1,NNC(=O)CCCCC(=O)NN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J36.606D,J-GLOBAL,NNC(=O)CCCCC(=O)NN,Train "JP_CHRIP: 2-Propyn-1-ol KR_NCIS: 2-Propyn-1-ol NZ_CCID: 2-Propyn-1-ol","JP_CHRIP: prop-2-yn-1-ol (synonym:2-Propyn-1-ol) KR_NCIS: Propargyl alcohol; 1-propyne-3-ol; Propynyl alcohol; Ethynlcarbinol; 2-propynl alcohol; 2-propynol; 3-propynol NZ_CCID: 1-Hydroxy-2-propyne, 1-Propyn-3-ol, 2-Propynyl alcohol, 3-Hydroxy-1-propyne, 3-Propynol, Ethynyl carbinol, Ethynylcarbinol, Propynyl alcohol",107-19-7,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-mhlw-2005e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4FE7AA73-DB8C-45CA-AEB8-E9BA07C09AFF","JP_CHRIP: [Rationale for the Classification] Based on (1) and (2), it was classified in Category 1B. [Evidence Data] (1) There are reports that in two skin irritation tests with rabbits, irritation and superficial necrosis after application of this substance itself and mild irritation after application of a 10% solution were observed (PATTY (6th, 2012), ACGIH (7th, 2001)). (2) There is a report that in a skin irritation test (test method equivalent to OECD TG404) with rabbits, in the case of 1-minute application, slight necrosis was observed after 8 days and in the case of application for 5 or 15 minutes, severe necrosis was observed after 8 days (BUA 213 (1999), REACH registration dossier (Accessed Jul. 2018)). [Reference Data, etc.] (3) This substance was classified as ""Skin Irrit. 1B"" in EU CLP. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",Provided,"JP_CHRIP, KR_NCIS, NZ_CCID",3,OCC#C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J13B,J-GLOBAL,C#CCO,Train "AU_HCIS: chloroacetaldehyde JP_CHRIP: chloroacetaldehyde","AU_HCIS: Acetaldehyde, chloro- JP_CHRIP: Chloroacetaldehyde 2-Chloro-1-ethanal 2-Chloroacetaldehyde Monochloroacetaldehyde",107-20-0,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=910 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-2006e.html","JP_CHRIP: In the rabbit test, application of a 55% aqueous solution of the substance to the abdominal skin caused severe corrosion (DFGMAK-Doc.12 (1999)). In another rabbit test, application of a 30% aqueous solution of the substance caused severe damage to skin (ACGIH (2001)). Based on these documents, the substance was classified as Category 1. As relevant information, the substance was classified as ""C; R34"" in the EU classification (EU-Annex I (Access on Jun. 2009)).",,"AU_HCIS, JP_CHRIP",2,ClCC=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.060F,J-GLOBAL,O=CCCl,Train "EU_REACH: 1,4-Dimethyl-1H-pyrazole",,1072-68-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18375/7/4/2/?documentUUID=7d543a91-d584-47a8-88a8-6e634e26088b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CN(N=C1)C,https://pubchem.ncbi.nlm.nih.gov/compound/136836,PubChem,Cc1cnn(C)c1,Train "JP_CHRIP: Chloromethyl methyl ether","JP_CHRIP: Bis(chloromethyl)ether; chloromethyl methyl ether (technical-grade) Chloromethoxymethane Chloromethyl methyl ether (technical-grade) CMME Dimethylchloroether",107-30-2,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-2023e.html,"JP_CHRIP: Based on reports that application to the skin of animals resulted in erythema and necrosis (EHC 201 (1998)) and that contact with the substance can induce a risk of chemical injury or necrosis in humans (ACGIH (2001)), the substance was classified into Category 1.",,JP_CHRIP,1,COCCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.063K,J-GLOBAL,COCCl,Train "KR_NCIS: Performic acid",,107-32-4,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C(=O)OO,https://pubchem.ncbi.nlm.nih.gov/compound/66051,PubChem,O=COO,Train "EU_REACH: 2,2,4,4,6,6-hexamethyl-3,5-dioxa-2,4,6-trisilaheptane",,107-51-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16055/7/4/2/?documentUUID=d6ba6aac-bc83-4063-96af-881fe340ad45,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/24705,PubChem,C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C,Train "EU_REACH: 2,2,4,4,6,6,8,8,10,10,12,12-dodecamethyl-3,5,7,9,11-pentaoxa-2,4,6,8,10,12-hexasilatridecane",,107-52-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20234/7/4/2/?documentUUID=55ac556e-5b08-4c40-90a7-603a32452e5b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/7875,PubChem,C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C,Train "AU_HCIS: Phosphoric acid, dibutyl ester JP_CHRIP: Di-n-butyl phosphate","JP_CHRIP: Di-n-butyl phosphate Dibutyl acid o-phosphate dibutyl phosphate Phosphoric acid dibutyl ester Phosphoric acid, dibutyl ester",107-66-4,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6822 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2019e.html","JP_CHRIP: [Rationale for the Classification] Based on (1), it was classified in Category 1. Besides, the category was changed due to the new data obtained. [Evidence Data] (1) In an in vitro skin corrosion test using an artificial human epidermis model (EST-1000) in compliance with OECD TG 431, following 3 minutes and 60 minutes of exposure, cell viabilities were 64% and 2%, respectively (REACH registration dossier (Access on July 2019)). [Reference Data, etc.] (2) It was highly irritating in a skin irritation test in which 0.5 mL was administered semi-occlusively to the ears of rabbits for 8 hours (ACGIH (7th, 2009), SIDS (2004)). (3) This substance may cause irritation of the skin in humans (HSDB (Access on June 2019)).",,"AU_HCIS, JP_CHRIP",2,CCCCOP(=O)(O)OCCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J150.769I,J-GLOBAL,CCCCOP(=O)(O)OCCCC,Train "KR_NCIS: Bis(2,4,4-trimethylpentyl)phosphinodithioic acid",,107667-02-7,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CC(CC(C)(C)C)CP(=S)(CC(C)CC(C)(C)C)S,https://pubchem.ncbi.nlm.nih.gov/compound/163778,PubChem,CC(CC(C)(C)C)CP(=S)(S)CC(C)CC(C)(C)C,Train "NZ_CCID: Isopentylamine",,107-85-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E42E4204-12D3-4C54-9191-3FC8D54CE4E2,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)CCN,https://pubchem.ncbi.nlm.nih.gov/compound/7894,PubChem,CC(C)CCN,Train "JP_CHRIP: 3-Methyl-2-butenal","JP_CHRIP: 3,3-Dimethylacrolein 3-Methylcrotonaldehyde",107-86-8,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0036e.html,"JP_CHRIP: In a test by an occlusive application of undiluted this substance to the rabbit skin for 3 minutes, 1 hour, or 4 hours, edema, erythema, and necrosis were observed from 1 hour after the application, necrosis that occurred hardened with time and became leather-like, and this persisted until day 8, the end of the observation period. As a result, it was judged as corrosive (SIDS (2003)), therefore it was classified in Category 1C. Besides, it is reported that necrosis in addition to erythema and edema were also found in another test by a 20-hour occlusive application of undiluted this substance to the rabbit skin, and it was assessed to be corrosive (SIDS (2003)).",,JP_CHRIP,1,CC(=CC=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J9.338F,J-GLOBAL,CC(C)=CC=O,Train "EU_REACH: butyric acid JP_CHRIP: butyric acid NZ_CCID: Butyric acid","JP_CHRIP: 1-Propanecarboxylic acid Butanic acid Ethylacetic acid n-Butanoic acid",107-92-6,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13507/7/4/2/?documentUUID=93aea964-09a1-4fae-ad50-7b7cbac551aa JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0159e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B2AFBB3F-959A-4F22-A238-D2B061D4F1F1","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: In List 1 data (PATTY (5th, 2001)), the substance is documented to be a severe irritant in rabbit tests, and in List 2 data (IUCLID (2000)), it is reported to be corrosive in rabbit tests (OECD Guidelines 404). In addition, it is rated as R34 in the EU classification. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",Provided,"EU_REACH, JP_CHRIP, NZ_CCID",3,CCCC(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.068A,J-GLOBAL,CCCC(=O)O,Train "JP_CHRIP: 3-Chloropropionic acid NZ_CCID: 3-Chloropropionic acid","JP_CHRIP: 3-Chloropropionic acid Propanoic acid, 3-chloro-",107-94-8,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2037e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B7EDFCF0-F122-4BE5-BAA3-19B92CC7E6C6","JP_CHRIP: [Rationale for the Classification] It was classified in Category 1 from (1), (2). [Evidence Data] (1) The pH of this substance (200 g/L) was 0.9 (GESTIS (Access on May 2020)). (2) This substance and its aqueous solutions were strong irritative/corrosive to the eye and skin (GESTIS (Access on May 2020)). NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,OC(=O)CCCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.069J,J-GLOBAL,O=C(O)CCCl,Train "EU_REACH: β-alanine",,107-95-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2084/7/4/2/?documentUUID=d7e37368-f9ac-430c-90cc-889f6f27ce53,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CN)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/239,PubChem,NCCC(=O)O,Train "JP_CHRIP: beta-Mercaptopropionic acid NZ_CCID: 3-Mercaptopropionic acid",,107-96-0,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0161e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8C417E85-018E-4EAB-9F06-9D09571A24E0","JP_CHRIP: The substance was classified as Category 1 based on the documented case of ""corrosive"" (SIDS (2009)) resulted from the rabbit test in which necrosis and burns accompanied by erythema and edema were observed within 15 minutes of occlusive application of the test substance. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,OC(=O)CCS,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J38.166G,J-GLOBAL,O=C(O)CCS,Train "NZ_CCID: Chlorodiphenylphosphine",,1079-66-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7C22DC71-BBFE-4D3A-B969-4C56939405CC,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)P(C2=CC=CC=C2)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/66180,PubChem,ClP(c1ccccc1)c1ccccc1,Train "NZ_CCID: 1,2-Ethanediamine, N,N-dimethyl-","NZ_CCID: N,N-dimethylethylenediamine",108-00-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/39607F72-2040-486E-B82E-2BCA0E277514,"NZ_CCID: Skin Irritation UN CLASS: PG II",,NZ_CCID,1,CN(C)CCN,https://pubchem.ncbi.nlm.nih.gov/compound/66053,PubChem,CN(C)CCN,Train "AU_HCIS: Ethanol, 2-(dimethylamino)- JP_CHRIP: 2-dimethylaminoethanol; N,N-dimethylethanolamine NZ_CCID: Dimethylaminoethanol US_HSDB: 2-DIMETHYLAMINOETHANOL","AU_HCIS: 2-dimethylaminoethanol N,N-dimethylethanolamine JP_CHRIP: 2-dimethylaminoethanol Dimethylethanolamine N,N-Dimethyl-2-hydroxyethylamine N,N-dimethylethanolamine NZ_CCID: (2-Hydroxyethyl)dimethylamine, 2-(Dimethylamino) ethanol, 2-(Dimethylamino)-1-ethanol, 2-(Dimethylamino)ethanol, 2-(N,N-Dimethylamino)ethanol, 2-Dimethylaminoethanol, Bimanol, Deanol, Dimethyl(2-hydroxyethyl)amine, Dimethyl(hydroxyethyl)amine, Dimethylethanolamine, Dimethylmonoethanolamine, Ethanol, 2-(dimethylamino)-, N,N-Dimethyl-2-aminoethanol, N,N-Dimethyl-2-hydroxyethylamine, N,N-Dimethyl-N-(2-hydroxyethyl)amine, N,N-Dimethylaminoethanol, N,N-Dimethylethanolamine, N-(2-Hydroxyethyl)dimethylamine, Norcholine, Propamine A, Texacat DME",108-01-0,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1879 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0034e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/11B13060-5626-4367-8D9D-F5F7DAA55F78 US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1329","JP_CHRIP: Since GLP tests using rabbits concluded that the substance was corrosive (IUCLID, 2000), it was classified into Category 1. NZ_CCID: Skin Irritation R-PHRASE: R 34. [N-CLASS] Eye Irritation R-PHRASE: R 34. [N-CLASS]",,"AU_HCIS, JP_CHRIP, NZ_CCID, US_HSDB",4,CN(C)CCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.068G,J-GLOBAL,CN(C)CCO,Train "EU_REACH: 4-methylpentan-2-one JP_CHRIP: Methyl isobutyl ketone","JP_CHRIP: 4-Methyl-2-pentanone 4-Methyl-2-pentanone; Methyl isobutyl ketone 4-methylpentan-2-one Hexone Isopropylacetone methylisobutyl ketone methylisobutyl ketone(2-methyl-4-pentanone) MIBK",108-10-1,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14866/7/4/2/?documentUUID=61c2bbba-4873-420b-b530-05db459b7160 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0099e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: There is a report that in a skin irritation test with rabbits, as a result of an occlusive application with this substance for 10 hours, erythema was persistent until after 24 hours (SIDS (2011), EHC117 (1990), NTP TR 538 (2007)). In addition, there is a report that in a skin irritation test with guinea pigs, as a result of an application of this substance (5 or 10 mL), slight irritation was observed (DFGOT Vol. 13 (1999), PATTY (6th, 2012)). From the above, based on reports that recovery property was observed and slight irritation was observed, this substance was classified as ""Not classified"" (Category 3 in UN GHS classification).",Provided,"EU_REACH, JP_CHRIP",2,CC(C)CC(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.861D,J-GLOBAL,CC(=O)CC(C)C,Train "NZ_CCID: Isopentanoyl chloride","NZ_CCID: isovaleryl chloride",108-12-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/867E4D5E-34C4-417A-A200-391425F8F73A,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)CC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/66054,PubChem,CC(C)CC(=O)Cl,Train "NZ_CCID: 1-(Dimethylamino)-2-propanol",,108-16-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/741C2CB9-124E-45D9-BCFF-B9F7FA9CCF1B,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(CN(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/37511,PubChem,CC(O)CN(C)C,Train "EU_REACH: bis(propan-2-yl)amine JP_CHRIP: Diisopropylamine NZ_CCID: 2-Propanamine, N-(1-methylethyl)-","JP_CHRIP: Diisopropylamine DIPA N-(1-methylethyl)-2-propanamine NZ_CCID: Diisopropylamine, n-(1-Methylethyl)-2-propanamine",108-18-9,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13145/7/4/2/?documentUUID=a6ad48e3-cf29-472e-b939-e9846a21f2ca JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2118e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E0E0E3EE-5825-41B8-BEC5-AE9A27E04CEA","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: In a skin irritation test with rabbits (OECD TG 404 compliant), clear evidence of necrosis (discoloration to reddish brown and greenish brown at the application site) was observed within 24 hours after the 3-minute application of this substance. This was followed by drying and roughening, resulting in desquamation and open wounds, and becoming scarred. There is a description that the skin tissue showed irreversible damage in all its layers (ECHA registration information (Access on December 2017)). In addition, there is a description that alkylamines including this substance cause strong skin irritation and corrosivity (SIAP (2013)) and a description that the pH of this substance was 12.5 (HSDB (Access on August 2017)). Therefore, it was classified in Category 1A. Besides, in EU CLP classification, this substance is classified as ""Skin Corr. 1B, H314"" (ECHA CL Inventory (Access on August 2017)). NZ_CCID: Skin Irritation R-PHRASE: R 34 Causes burns. [IUCLID 2000] Eye Irritation SPECIES: Rabbit RESULT: Highly corrosive REFERENCE SOURCE: Atochem Paris la Defense (22) AMA-Arch-Ind-Hyg-Occup-med, vol 10, pg 61, (AMIHBC). [IUCLID 2000] REMARK: EC Classification: Risk of serious damage to eyes.",Provided,"EU_REACH, JP_CHRIP, NZ_CCID",3,CC(C)NC(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.496F,J-GLOBAL,CC(C)NC(C)C,Train "JP_CHRIP: Isopropyl ether","JP_CHRIP: 2,2'-Oxybispropane 2-Isopropoxypropane diisopropyl ether Isopropyl ether",108-20-3,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2020e.html,"JP_CHRIP: [Rationale for the Classification] Based on (1), it was classified as ""Not classified."" [Evidence Data] (1) In a ski irritation test in which 0.5 mL of this substance was applied semiocclusively to the skin of rabbits for 4 hours in accordance with OECD TG 404, the mean scores at 24/48/72 hours for erythema and edema were 1.77 and 0.87, respectively (REACH registration dossier (Access on July 2019)). [Reference Data, etc.] (2) This substance had a slight irritative effect on the skin and caused irritation to the eyes of rabbits (DFGOT vol.21 (2005)).",Provided,JP_CHRIP,1,CC(C)OC(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.069E,J-GLOBAL,CC(C)OC(C)C,Train "EU_REACH: isopropenyl acetate",,108-22-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17298/7/4/2/?documentUUID=37ceb158-2d81-44c8-ab37-dc1cdb5a3eb5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)OC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/7916,PubChem,C=C(C)OC(C)=O,Train "JP_CHRIP: Isopropyl chloroformate","JP_CHRIP: Carbonochloridic acid 1-methylethyl ester Chloroformic acid, isopropyl ester isopropyl 1-chloromethanoate Isopropyl chlorocarbonate isopropyl chloroformate Isopropyl chloromethanate",108-23-6,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0067e.html,"JP_CHRIP: Based on a report that direct dropwise application to the skin causes deep necrosis and eschar formation in a guinea pig test (PATTY (5th, 2001)) and a report of ""irritating and corrosive to the skin"" (HSDB (2003)), the substance was classified into Category 1.",,JP_CHRIP,1,CC(C)OC(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J34.720E,J-GLOBAL,CC(C)OC(=O)Cl,Train "JP_CHRIP: Acetic anhydride NZ_CCID: Acetic anhydride US_HSDB: Acetic anhydride","JP_CHRIP: Acetic acid, anhydride Acetic oxide Acetyl oxide Ethanoic anhydride NZ_CCID: Acetanhydride, Acetic acid, anhydride, Acetic oxide, Acetyl acetate, Acetyl anhydride, Acetyl ether, Acetyl oxide, Ethanoic anhydride",108-24-7,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2021e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/54C46A7E-73BC-4DB8-A03B-0BF27040E37C US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/233","JP_CHRIP: [Rationale for the Classification] Based on (1)-(4), it was classified in Category 1. [Evidence Data] (1) This substance is a severe irritant to the eyes, mucous membranes and skin, and severe burns and vesiculation of the skin were reported from liquid splashes (ACGIH (7th, 2001)). (2) In a skin irritation test with rabbits, under occluded conditions for 24 hours, it caused severe burns and blisters (ACGIH (7th, 2011)). (3) This substance is corrosive to the skin, eyes and mucous membranes (SIDS (2002)). (4) This substance is severely irritating to the skin and eyes, and direct contact with the liquid may result in burns (OEL Documentations (Japan Society For Occupational Health (JSOH), 1990), HSDB (Access on June 2019)). [Reference Data, etc.] (5) It was reported that it was mildly irritative in a skin irritation test in which 0.5 mL of this substance was applied to rabbits for 24 hours (DFGOT vol.13 (1999), SIDS (2002)). (6) It was classified in Skin Irrit. 1B (H314) in the EU CLP Classification (EU CLP classification (Access on July 2019)). NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,CC(=O)OC(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.417A,J-GLOBAL,CC(=O)OC(C)=O,Train "AU_HCIS: maleic anhydride JP_CHRIP: Maleic anhydride NZ_CCID: Maleic anhydride US_HSDB: MALEIC ANHYDRIDE","AU_HCIS: 2,5-Furandione JP_CHRIP: 2,5-Furandione cis-Butenedioic anhydride Dihydro-2,5-dioxofuran Maleic acid anhydride Maleic anhydride NZ_CCID: 2,5-Furandione, Dihydro-2,5-dioxofuran, Maleic acid anhydride, Toxilic anhydride, cis-Butenedioic anhydride",108-31-6,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=2795 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-2026e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9FAACCC4-8E62-4C8D-A7E6-A40199911812 US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/183","JP_CHRIP: It is described in DFGOT vol. 4 (1992) that the application of the powder moistened with water caused necrosis in a skin irritation test with rabbits, although it is not a result of a 4-hour application. And it is described in SIDS (2007) that there was severe irritation in a skin irritation test with rabbits by a 4-hour application. Furthermore, this substance is classified in ""C; R34"" in EU DSD classification and ""Skin Corr. 1B H314"" in EU CLP classification. SIDS (2007), EU DSD classification, and EU CLP classification were obtained in this investigation and added. The classification was changed to Category 1 because the information on sub-categorization could not be obtained (the information that irritation in a Draize test with rabbits or human findings is mild and disappear within seven days). NZ_CCID: Skin Irritation R-PHRASE: R 34. [ECB]/ N-Class Eye Irritation R-PHRASE: R 34. [ECB]/ N-Class",,"AU_HCIS, JP_CHRIP, NZ_CCID, US_HSDB",4,O=C1OC(=O)C=C1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.419H,J-GLOBAL,O=C1C=CC(=O)O1,Train "JP_CHRIP: propylene carbonate","JP_CHRIP: 2-oxo-4-methyl-1,3-dioxolane propylene carbonate",108-32-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0160e.html,"JP_CHRIP: The classification is based on descriptions that the substance was found to be a slight irritant in rabbit tests (PATTY (5th, 2001)) and it caused no irritation in other rabbit tests (OECD Guidelines 404) (IUCLID (2000)).",Provided,JP_CHRIP,1,CC1COC(=O)O1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.073C,J-GLOBAL,CC1COC(=O)O1,Train "AU_HCIS: m-cresol [1] JP_CHRIP: m-Cresol KR_NCIS: m-Cresol NZ_CCID: 3-Cresol US_HSDB: m-CRESOL","AU_HCIS: o-cresol [2] p-cresol [3] mix-cresol [4] Phenol, 3-methyl- m-cresol o-cresol p-cresol JP_CHRIP: 1-Hydroxy-3-methylbenzene 3-Cresol 3-Hydroxytoluene 3-Methylphenol cresol m-cresol m-Cresol; 3-Methylphenol Phenol, 3-methyl- KR_NCIS: 1-Hydroxy-3-methylbenzene; 1-Hydroxy-3-methylbenzol; 1-Oxy-3-methylbenzol; 3-Cresol; 3-Hydroxytoluene; 3-Hydroxytoluol; 3-Kresol; 3-Methylphenol; m-Cresylic acid; m-Hydroxytoluene; M-Hydroxytoluol; M-Kresol; M-Kresylsaeure; m-Methylphenol; M-Oxytoluol; M-Tolylalkohol; Phenol, 3-Methyl; Phenol, 3-methyl- NZ_CCID: 1-Hydroxy-3-methylbenzene, 3-Hydroxytoluene, 3-Methyl phenol, Metacresol, m-Cresol",108-39-4,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1066 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2137e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/64AA8ADA-9DD7-4180-A4DD-37D14CC47600 US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1815","JP_CHRIP: There is a report that when 0.5 mL of the undiluted liquid of this substance was applied to the skin of rabbits, severe erythema and edema occurred within 24 hours and this did not disappear within 72 hours (SIDS (2005)). In other tests with rabbits, there is a report that irreversible tissue destruction was observed 4 hours after application of this substance (EHC 168 (1995)), and that severe irritation and corrosion were observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)). From the above results, it was classified in Category 1. Besides, this substance was classified in ""C; R34"" in EU DSD classification and in ""Skin Corr. 1B H314"" in EU CLP classification. NZ_CCID: Skin Irritation SPECIES: Rabbit RESULT: Dermal application of cresols (0.5 ml of o-, m- or p-cresol or a technical mixture of all three isomers) for 4 h caused visible and irreversible tissue destruction. REFERENCE SOURCE: (Vernot et al., 1977). Cresols (EHC 168, 1995) [INCHEM] Eye Irritation R-PHRASE: R 34 Causes burns. [N-CLASS]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,Cc1cccc(O)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.186J,J-GLOBAL,Cc1cccc(O)c1,Train "EU_REACH: tert-butyl (2S)-2-[5-(4'-{2-[(2S)-1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl]-1H-imidazol-5-yl}-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylate",,1085706-46-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6021/7/4/2/?documentUUID=629fb0da-1cd8-4863-a858-26f103bc9944,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)OC(=O)N1CCC[C@H]1C2=CC(=NN2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)[C@@H]6CCCN6C(=O)OC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/59345130,PubChem,CC(C)(C)OC(=O)N1CCC[C@H]1c1cc(-c2ccc(-c3ccc(-c4cnc([C@@H]5CCCN5C(=O)OC(C)(C)C)[nH]4)cc3)cc2)n[nH]1,Train "EU_REACH: 2,4,6,8-tetramethyl-1,3,5,7-tetraoxocane JP_CHRIP: 2,4,6,8-Tetramethyl-1,3,5,7-tetraoxacyclooctane","JP_CHRIP: 2,4,6,8-tetramethyl-1,3,5,7-tetraoxacyclooctane (synonym:metaldehyde) metaldehyde",108-62-3,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24890/7/4/2/?documentUUID=76e6ec4f-e828-4812-a5d5-db97444d7c48 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0185e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: Based on a report of ""not irritant"" in a rabbit test (EPA RED (2006), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2009)).",Provided,"EU_REACH, JP_CHRIP",2,CC1OC(C)OC(C)OC(C)O1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.423F,J-GLOBAL,CC1OC(C)OC(C)OC(C)O1,Train "JP_CHRIP: 3,5-xylenol; 3,5-Dimethylphenol KR_NCIS: 3,5-Dimethylphenol NZ_CCID: Phenol, 3,5-dimethyl-","JP_CHRIP: 3,5-Xylenol Phenol, 3,5-dimethyl- KR_NCIS: 1,3,5-Xylenol; 1-Hydroxy-3,5-dimethylbenzene; 3,5-Xylenol; Phenol, 3,5-dimethyl-; XYLENOL NZ_CCID: 3,5-XYLENOL",108-68-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2028e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9D1BCFDA-2209-4D23-A4E5-DA83B7A37971","JP_CHRIP: [Rationale for the Classification] Based on (1) and (2), it was classified in Category 1. [Evidence Data] (1) Moderate burns to the skin were reported in rabbits after administration to the skin (concentration not specified) (NICNAS IMAP (Access on August 2019)). (2) It was classified in ""Skin Corr. 1B (H314)"" in EU-CLP classification (EU CLP classification (Access on May 2019)). [Reference Data, etc.] (3) In a 24-hour occlusive skin irritation study with rabbits (Polyethylene glycol (PEG) 400 was used as vehicle), slight edema was observed in half of the animals at 24 hours after application and disappeared after 72 hours. PII was 0.25 (ACGIH (7th, 2019), (REACH registration dossier (Access on July 2019))). NZ_CCID: Skin Irritation SPECIES: RESULT: Corrosive REFERENCE SOURCE: [NTP] Eye Irritation SPECIES: RESULT: Corrosive REFERENCE SOURCE: [NTP]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,Cc1cc(C)cc(O)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.425B,J-GLOBAL,Cc1cc(C)cc(O)c1,Train "JP_CHRIP: Melamine","JP_CHRIP: 1,3,5-Triazine-2,4,6-triamine 2,4,6-Triamino-1,3,5-triazine 2,4,6-triamino-1,3,5-triazine (melamine) Cyanurotriamide",108-78-1,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-0004e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1) - (3). [Evidence Data] (1) No skin reactions were observed in a skin irritation test with rabbits according to OECD TG 404 (REACH registration dossier (Access on June 2020)). (2) In a patch test in humans, no skin irritation or sensitization was found. And dermatitis was reported from the manufacture of melamine-formaldehyde resins or intermediate reaction products of formaldehyde and this substance, but not this substance itself (Environmental Risk Assessment for Chemical Substances vol. 8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010)). (3) This substance produced little or no irritation or sensitization when its 1% aqueous solution was applied to the guinea pig skin under occlusion. There was a similar result also in rabbits (Patty (6th, 2012), GESTIS (Access on April 2020)).",Provided,JP_CHRIP,1,Nc1nc(N)nc(N)n1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.428G,J-GLOBAL,Nc1nc(N)nc(N)n1,Train "JP_CHRIP: 2,6-Dimethylheptan-4-ol",,108-82-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0037e.html,"JP_CHRIP: The substance was classified as ""Not classified"" based on the rabbit test (OECD TG404) in which erythema and edema were not observed at 24, 48 and 72 hours after patch removal, and the PII was 0 (ECETOC TR66 (1995)).",Provided,JP_CHRIP,1,CC(C)CC(O)CC(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J58.121F,J-GLOBAL,CC(C)CC(O)CC(C)C,Train "JP_CHRIP: Diisobutyl ketone","JP_CHRIP: 2,6-Dimethyl-4-heptanone 2,6-dimethylheptan-4-one Isovalerone",108-83-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0095e.html,"JP_CHRIP: As for skin irritation tests (OECD TG404) with rabbits, both results of slight irritation and no irritation are reported as a result of a semi-occlusive application of this substance for 4 hours (SIDS (2004)). In addition, there is a report that in other skin irritation test with rabbits, as a result of a semi-occlusive application of 0.5 mL of this substance for 4 hours, erythema (average score 1.9) and edema (average score 0.4) were observed, but resolved within 14 days after the application (SIDS (2004)). From the above, it was classified as ""Not classified"" (Category 3 in UN GHS classification).",Provided,JP_CHRIP,1,CC(C)CC(=O)CC(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.081D,J-GLOBAL,CC(C)CC(=O)CC(C)C,Train "AU_HCIS: cyclohexylamine JP_CHRIP: Cyclohexylamine KR_NCIS: Cyclohexylamine NZ_CCID: Cyclohexanamine","AU_HCIS: Cyclohexanamine aminocyclohexane aminohexahydrobenzene hexahydroaniline hexahydrobenzenamine JP_CHRIP: Aminocyclohexane Aminohexahydrobenzene Cyclohexanamine Cyclohexylamine Hexahydroaniline KR_NCIS: aminocyclohexane; hexahydroaniline NZ_CCID: 1-Aminocyclohexane, 1-Cyclohexylamine, Aminocyclohexane, Aminohexahydrobenzene, Benzenamine, hexahydro-, Cyclohexylamine, Hexahydroaniline",108-91-8,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1117 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-2009e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1D8BF38F-A57B-4567-A15D-34AFEB23507D","JP_CHRIP: Open application to the rabbit skin resulted in a damage level of 7 on a scale of 1 to 10 within 24 hours, necrosis was seen (DFGMAK-Doc. 22 (2006)), and it is reported that this substance was found to be corrosive after 4-hour or 24-hour semi-occlusive application of 0.5 mL to the rabbit skin (DFGMAK-Doc. 22 (2006)). Furthermore, by 24-hour occlusive application of undiluted this substance to the guinea pig skin, edema, necrosis, and persistent eschars were observed, and severe irritation was shown (ACGIH (2001)). It was classified in Category 1 based on the above findings. Besides, pH is 11.5 (100 g/L). NZ_CCID: Skin Irritation R-PHRASE: R 34. [N-CLASS] UN CLASS: 8, PG II Eye Irritation SPECIES: Rabbit RESULT: One drop of 50% AQ soln, applied to conjuntival sac of rabbit eye, caused complete destruction of eye. REFERENCE SOURCE: [American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values, 4th ed., 1980. Cincinnati, Ohio: American Conference ofGovernmmental Industrial Hygienists, Inc., 1980. 113]**QC REVIEWED**[HSDB] R-PHRASE: R 34. [N-CLASS]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID",4,NC1CCCCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.870C,J-GLOBAL,NC1CCCCC1,Train "JP_CHRIP: Phenol KR_NCIS: Phenol NZ_CCID: Phenol","JP_CHRIP: Benzenol Carbolic acid Hydroxybenzene Phenic acid phenol, pure KR_NCIS: Hydroxybenzene NZ_CCID: (Mono)hydroxybenzene, Benzenol, Carbolic acid, Oxybenzene, Phenic acid, Phenyl alcohol, Phenyl hydrate, Phenyl hydroxide, Phenylic acid, Phenylic alcohol",108-95-2,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2007.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3817198F-CE0B-4133-87EE-5EE65B03E140","JP_CHRIP: 【分類根拠】 （１）～（５）より区分1とした。 【根拠データ】 （１）本物質を含有する皮膚局所薬剤投与で刺激性皮膚炎の発生がみられ、皮膚への局所ばく露では、その部位に漂白作用又は紅疹が発生し、腐食や壊死に到る場合がある（CERI 有害性評価書 (2008)、MOE 初期評価 (2002)）。 （２）本物質はヒトが経口及び経皮ばく露すると、皮膚、眼及び粘膜に対して強い刺激性を示す（CERI 有害性評価書 (2008)）。 （３）本物質はウサギの皮膚に腐食性を示した（EPA Pesticides RED (2009)）。 （４）ウサギ、ラット、マウス、ブタの眼又は皮膚に本物質を適用した結果、発赤、炎症、変色、発疹、潰瘍、壊死、腐食性を認めたとする報告がみられ、眼や皮膚に対する強い刺激性ないし腐食性を示すと考える（CERI 有害性評価書 (2008)、CEPA PSAR (2000)、EHC (1994)）。 （５）In vitro 皮膚腐食性試験（OECD TG 431）において、皮膚腐食性がみられたとの報告がある（AICIS IMAP (2014)）。 【参考データ等】 （６）本物質は、平成8年労働省告示第33号（平成25年厚生労働省告示第316号により改正）において、労働基準法施行規則別表第一の二第四号1の厚生労働大臣が指定する単体たる化学物質及び化合物（合金を含む。）に「フェノール(別名石炭酸)」として指定されており、本物質にさらされる業務による、特定の症状又は障害を主たる症状又は障害とする疾病（頭痛、めまい、嘔吐等の自覚症状、皮膚障害、前眼部障害又は気道・肺障害）が、業務上の疾病として定められている。 NZ_CCID: Skin Irritation REMARK: C ? 10 % T; R23/24/25-48/20/21/22-34-68 3 % ? C < 10 % C ; Xn ; R20/21/22-34-68 1 % ? C < 3 % Xn ; R36/38-68 REFERENCE SOURCE: [ECB Annex] NOTE: Classified as corrosive based on R34 risk phrase. Eye Irritation REMARK: C ? 10 % T; R23/24/25-48/20/21/22-34-68 3 % ? C < 10 % C ; Xn ; R20/21/22-34-68 1 % ? C < 3 % Xn ; R36/38-68 REFERENCE SOURCE: [ECB Annex] NOTE: Classified as corrosive based on R34 risk phrase.",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,Oc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.873H,J-GLOBAL,Oc1ccccc1,Train "NZ_CCID: 1-Methylpiperazine",,109-01-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6ED348DF-57B5-421A-9526-51D40A328D78,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data",,NZ_CCID,1,CN1CCNCC1,https://pubchem.ncbi.nlm.nih.gov/compound/53167,PubChem,CN1CCNCC1,Train "NZ_CCID: Morpholine, 4-methyl-","NZ_CCID: 4-methylmorpholine",109-02-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/891B9007-ED91-4267-B18A-5FF4BCA0B94E,"NZ_CCID: Skin Irritation UN CLASS: Sub Risk 8; PG II R PHRASE: R 34 [MSDS, ABCR Gmbh and Co.] [Chemfinder] Eye Irritation R-PHRASE: R 34. MSDS, ABCR Gmbh and Co. [Chemfinder]",,NZ_CCID,1,CN1CCOCC1,https://pubchem.ncbi.nlm.nih.gov/compound/7972,PubChem,CN1CCOCC1,Train "JP_CHRIP: 2-Methylpyridine (2-Picoline)","JP_CHRIP: 2-methylpyridine 2-Picoline alpha-Picoline o-Picoline Pyridine, 2-methyl-",109-06-8,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-mhlw-2021e.html,"JP_CHRIP: [Rationale for the Classification] Based on (1) and (2), it was classified in Category 1. Besides, information for subcategorization was not obtained. [Evidence Data] (1) There is a report that in a skin irritation test (U.S. 49 CFR 173.240) with rabbits (n=6), after a 4-hour occlusive application of this substance, ulceration or necrosis was observed in all animals (REACH registration dossier (Accessed Sept. 2018)). (2) Although the animal species is unknown, this substance is moderately to severely irritating, and signs of necrosis, ulceration and regeneration are reported (PATTY (6th, 2012)).",,JP_CHRIP,1,Cc1ccccn1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.087C,J-GLOBAL,Cc1ccccn1,Train "EU_REACH: 2-(chloromethyl)-4-methylquinazoline",,109113-72-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5361/7/4/2/?documentUUID=da6ee861-4d6c-48d7-8dbb-ae69aff4d045,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=NC(=NC2=CC=CC=C12)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/241518,PubChem,Cc1nc(CCl)nc2ccccc12,Train "EU_REACH: tert-butyl 2-methylpropaneperoxoate",,109-13-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11987/7/4/2/?documentUUID=3211c910-debc-4194-acf9-fb39a6a268b8,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C(=O)OOC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/61023,PubChem,CC(C)C(=O)OOC(C)(C)C,Train "EU_REACH: docosyl 4-hydroxybenzoate",,109236-76-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17137/7/4/2/?documentUUID=80544fc4-ffef-4ee8-859c-e3003de26978,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCCCCCCCOC(=O)C1=CC=C(C=C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/13923401,PubChem,CCCCCCCCCCCCCCCCCCCCCCOC(=O)c1ccc(O)cc1,Train "AU_HCIS: 9-Octadecenamide, N-[3-(dimethylamino)propyl]-, (Z)-",,109-28-4,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6760,,,AU_HCIS,1,CCCCCCCC/C=C\CCCCCCCC(=O)NCCCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6436063,PubChem,CCCCCCCC/C=C\CCCCCCCC(=O)NCCCN(C)C,Train "EU_REACH: oxacycloheptadecan-2-one",,109-29-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24078/7/4/2/?documentUUID=6c9e667b-e071-43c6-9639-68604402dd91,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CCCCCCCC(=O)OCCCCCCC1,https://pubchem.ncbi.nlm.nih.gov/compound/7984,PubChem,O=C1CCCCCCCCCCCCCCCO1,Train "EU_REACH: 1,3-dibutyl-2-thiourea",,109-46-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26084/7/4/2/?documentUUID=06e11ce9-90d4-4319-9d3e-083179e35202,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCNC(=S)NCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/2723622,PubChem,CCCCNC(=S)NCCCC,Train "JP_CHRIP: valeric acid NZ_CCID: Pentanoic acid","JP_CHRIP: 1-Butanecarboxylic acid n-Pentanoic acid Propylacetic acid Valeric acid NZ_CCID: valeric acid",109-52-4,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0092e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DF30F573-B567-4F11-8DF4-D2F4F6318CCD","JP_CHRIP: Since there is a description that, valeric acid is a strong skin irritant in undiluted form (PATTY (5th, 2001)), and valeric acid is rated iC; R34 by EU (EU-AnnexI (accessed August 2008)), the substance was classified into Category 1. As relevant information, it is reported that using mixed isomers of valeric acid demonstrated some tissue necrosis in a 24h rabbit skin irritation assay (PATTY (5th, 2001)). NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CCCCC(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.504K,J-GLOBAL,CCCCC(=O)O,Train "AU_HCIS: 3-aminopropyldimethylamine JP_CHRIP: 3-aminopropyldimethylamine; N,N-dimethyl-1,3-diaminopropane NZ_CCID: 3-Dimethylaminopropylamine","AU_HCIS: N,N-dimethyl-1,3-diaminopropane 1,3-Propanediamine, N,N-dimethyl- JP_CHRIP: 1,3-Propanediamine, N,N-dimethyl- 1-Amino-3-dimethylaminopropane 3-aminopropyldimethylamine N,N,-Dimethyl-1,3-propanediamine N,N-Dimethyl-1,3-diaminopropane NZ_CCID: N,N-Dimethyltrimethylenediamine",109-55-7,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=219 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0037e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6DBCCA85-778B-4CE8-9459-D51F291EE5FA","JP_CHRIP: There are several reports characterizing the substance as strongly irritating to corrosive in rabbit tests (IUCLID (2000), BUA report No. 197 (1996)). In addition, the substance was documented to cause necrosis as its dermal symptom (BUA report No. 197 (1996)). As such, the substance was classified into Category 1. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CN(C)CCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J50.732F,J-GLOBAL,CN(C)CCCN,Train "JP_CHRIP: Propyl chloroformate KR_NCIS: n-Propyl chloroformate","JP_CHRIP: Carbonochloridic acid, propyl ester Formic acid, chloro-, propyl ester Propyl chlorocarbonate KR_NCIS: Carbonochloridic acid, propyl ester; CHLOROFORMATE, PROPYL; Formic acid, chloro-, propyl ester; n-Propyl chloroformate; Propyl chlorocarbonate; Propyl chloroformate",109-61-5,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2023e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","JP_CHRIP: [Rationale for the Classification] Based on (1), it was classified in Category 1B. [Evidence Data] (1) In a skin corrosion test in which 0.5 mL of this substance was applied to two rabbits, it was corrosive, and persistent erythema, edema and necrosis were observed after 15-minute and 20-hour exposure (SIDS (2012), REACH registration dossier (Access on July 2019)). [Reference Data, etc.] (2) In a skin irritation test in which 0.5 mL of this substance was applied to rabbits under occlusive application for 24 hours, the mean scores of intact skins were 7.8 at 24 hours and 8.0 at 72 hours, and the mean scores of abraded skins were 8.0 both at 24 hours and 72 hours (SIDS Dossier (2012)). (3) It was classified as ""Skin Corr. 1B (H314)"" in the EU CLP classification (EU CLP classification (Access on July 2019)).",,"JP_CHRIP, KR_NCIS",2,CCCOC(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J34.719A,J-GLOBAL,CCCOC(=O)Cl,Train "JP_CHRIP: n-Pentane","JP_CHRIP: Amyl hydride n-Pentane",109-66-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2096e.html,"JP_CHRIP: Based on a primary irritation index of 0.67 in a skin irritation test with rabbits (OECD TG 404, GLP-compliant), it was judged not to be irritating (SIDS (2010), EU-RAR (2003)). In addition, it is described that this substance is not irritating as a result of 24-hour semi-occlusive application to humans (GLP-compliant) (EU-RAR (2003)). On the other hand, it is described that by skin contact with this substance, degreasing and irritation occurred (OEL Documentations (Japan Society for Occupational Health (JSOH), 1987)), and that after skin application to volunteers, there was irritation such as pain, burning sensations and blisters, but no information on the test conditions and the degree of irritation were provided. Based on the above, the test result from the study according to the test guideline was adopted, and it was classified as ""Not classified.""",Provided,JP_CHRIP,1,CCCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J15I,J-GLOBAL,CCCCC,Train "JP_CHRIP: n-Butylamine KR_NCIS: n-Butylamine NZ_CCID: 1-Butanamine","JP_CHRIP: 1-Aminobutane Monobutylamine n-Butylamine KR_NCIS: 1-Butanamine; 1-aminobutane; Monobutylamine;Butan-1-amine NZ_CCID: 1-Aminobutane, Mono-n-butylamine, Monobutylamine, Norvalamine, n-Butylamine",109-73-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2119e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/04BD6D13-E553-4012-8A6A-1E85A90D7E82","JP_CHRIP: There is a description that in a skin irritation test with guinea pigs, necrosis occurred after application (OEL Documentations (Japan Society For Occupational Health, 1994)). There is a description that in a skin irritation test (equivalent to OECD TG 404) with rabbits, in exposure time of 1 minute, immediate necrosis occurred, eschar was produced, and it showed corrosivity (SIDS(2016)). Therefore, this substance was classified in Category 1. Besides, this substance was classified as ""Skin Corr.1A, H314"" in the EU CLP classification (ECHA CL Inventory (Access on August 2017)). NZ_CCID: Skin Irritation SPECIES: Guinea pig RESULT: N-Butylamine causes skin necrosis when applied at 0.5 ml/kg. REFERENCE SOURCE: [Peer Reviewed] Clayton, G.D., F.E. Clayton (eds.) Pattys Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994. 1105. [HSDB] R-PHRASE: R 35 Causes severe burns [IUCLID 2000] Eye Irritation SPECIES: RESULT: 10 and 50% v/v aqueous solutions and undiluted base produce severe eye burns in animals. The immediate eyen reaction is not appreciable altered by prolonged washing or attemps at neutralization when these are commenced within 15 sec after application REFERENCE SOURCE: BASF AG Ludwigshafen (81) Fasett D.W.: unpublished data; cited in: Pattys Industrial hyiene and Toxicology, Vol. IIB, 3155, (1982). [IUCLID 2000] R-PHRASE: R 35 Causes severe burns [IUCLID 2000]",Provided,"JP_CHRIP, KR_NCIS, NZ_CCID",3,CCCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.436H,J-GLOBAL,CCCCN,Train "NZ_CCID: 1,3-Diaminopropane","NZ_CCID: 1,3-propylenediamine",109-76-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6FA76FE5-2F11-461E-AB95-6CB542DBF178,"NZ_CCID: Skin Irritation UN #2734 UN CLASS: 8 PG II Eye Irritation R PHRASE: R 35 [Company Data] UN #2734 UN CLASS: 8 PG II",,NZ_CCID,1,C(CN)CN,https://pubchem.ncbi.nlm.nih.gov/compound/428,PubChem,NCCCN,Train "JP_CHRIP: 2-methylaminoethanol NZ_CCID: 2-(Methylamino) ethanol US_HSDB: 2-Methylaminoethanol","JP_CHRIP: (2-Hydroxyethyl)methylamine 2-(methylamino)ethanol 2-methylaminoethanol Methylethylolamine Monomethylethanolamine NZ_CCID: 2-methylaminoethanol",109-83-1,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0093e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C06F2FAD-F992-4DF1-992C-0526C97B09E2 US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1128","JP_CHRIP: The classification is based on the results of ""being corrosive"" after application to skin of rabbits for 1 - 4 hours (IUCLID (2000)). As relevant notes, its pH is 13.4 (100 mL/L) (IUCLID (2000)), and it is rated C;R34 in EU classification (EU-Annex 1 (accessed August 2008)). NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,CNCCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.187H,J-GLOBAL,CNCCO,Train "NZ_CCID: 2-Methoxyethylamine",,109-85-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0C11A983-26C0-468A-B6A0-04611D6017CE,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,COCCN,https://pubchem.ncbi.nlm.nih.gov/compound/8018,PubChem,COCCN,Train "EU_REACH: Isooctadecanoic acid, 1,1'-(2,2-dimethyl-1,3-propanediyl) ester",,109884-54-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17513/7/4/2/?documentUUID=5003d932-d1e9-490c-96ee-8adab9b79cf7,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCCCCCCCCCCC(=O)OCC(C)(C)COC(=O)CCCCCCCCCCCCCCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/10282874,PubChem,CC(C)CCCCCCCCCCCCCCC(=O)OCC(C)(C)COC(=O)CCCCCCCCCCCCCCC(C)C,Train "JP_CHRIP: Diethylamine NZ_CCID: Ethanamine, N-ethyl- US_HSDB: DIETHYLAMINE","JP_CHRIP: Diethamine N,N-Diethylamine N-Ethylethanamine NZ_CCID: Diethylamine, N,N-Diethylamine, n-Ethylethanamine",109-89-7,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2042e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5819CBE2-8F54-4733-8F2D-4C4262A0407E US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/524","JP_CHRIP: There are multiple reports that it was corrosive in tests with rabbits (ACGIH (7th, 2013), IUCLID (2000)). Additionally, there is a description that this substance was severely irritating, and the skin of the contact site was damaged (OEL Documentations (Japan Society For Occupational Health (JSOH), 1989)). From the above, it was classified in Category 1. Besides, this substance was classified as ""Skin"" by ACGIH, as ""C:R35"" in the EU DSD classification, and as ""H314 Skin Corr. 1A"" in the EU CLP classification. NZ_CCID: Skin Irritation R-PHRASE: R 35 Causes severe burns. [IUCLID 2000] [N-Class] Eye Irritation SPECIES: RESULT: Contact with liquid can damage eyes, possibly permanently. REFERENCE SOURCE: [Lewis, R.J. Saxs Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996. 1147]**PEER REVIEWED** [HSDB]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,CCNCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J807I,J-GLOBAL,CCNCC,Train "JP_CHRIP: Ethyl vinyl ether","JP_CHRIP: ethyl vinyl ether",109-92-2,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0048e.html,"JP_CHRIP: Based on reports of grade 1 (maximum grade 10) irritation after open application to the skin of rabbits (PATTY (5th, 2001)), and not irritating in another rabbit test (OECD TG404), the substance was classified as ""Not classified"".",Provided,JP_CHRIP,1,CCOC=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.440F,J-GLOBAL,C=COCC,Train "EU_REACH: 2-({3-[bis(cyanomethyl)amino]propyl}(cyanomethyl)amino)acetonitrile",,110057-45-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/4332/7/4/2/?documentUUID=8313cf05-f1e8-4098-8ad7-0ce8f2f0a05f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CN(CC#N)CC#N)CN(CC#N)CC#N,https://pubchem.ncbi.nlm.nih.gov/compound/314171,PubChem,N#CCN(CC#N)CCCN(CC#N)CC#N,Train "EU_REACH: succinic acid",,110-15-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15265/7/4/2/?documentUUID=42f74ea6-278b-4aac-bcbc-20d60bbcf2da,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CC(=O)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/1110,PubChem,O=C(O)CCC(=O)O,Train "JP_CHRIP: N,N,N',N'-tetramethylethylenediamine NZ_CCID: 1,2-Ethanediamine, N,N,N',N'-tetramethyl-","JP_CHRIP: N,N,N',N'-Tetramethyl-1,2-ethanediamine NZ_CCID: Propamine D, Temed, Tetrameen, Tetramethyl ethylene diamine, Tetramethyldiaminoethane",110-18-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0167e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/22193BD3-92A5-4F59-817B-BD1499249582","JP_CHRIP: In skin irritation tests using rabbits (HSDB (2002)), 1-hour and 4-hour applications resulted in full-thickness necrosis or ulceration and ecchymoses; and the necrosis persisted for 14 days. Based on this information, the substance was classified into Category 1. NZ_CCID: Skin Irritation SPECIES: Rabbit RESULT: Substance appears to be a corrosive with irreversible effects at day 14 REFERENCE SOURCE: Union Carbide Corp; Catalyst C-271: Acute Toxicity and Irritancy Testing Using the Rat (Peroral & Inhalation Toxicity) and the Rabbit (Cutaneous & Eye Tests); 08/24/93; EPA Document No. 89-930000176; Fiche No. OTS0538306] **UNREVIEWED** [HSDB] Eye Irritation SPECIES: Rabbit RESULT: Slight to moderate corneal opacity and iritis, and severe conjunctival irritation were common to all treated eyes, the corneal injury with hemorrhaging of the nictitating membrane developing by the 24th hour observation. A purulent ocular discharge was noted in 3/4 rabbits by 72 hours post-instillation. By Day 14, 2/4 treated rabbit eyes were free of all irritative signs. The remaining minor corneal vascularization and conjunctival irritation in 1 and 2 rabbits, respectively, persisted to Day 21 REFERENCE SOURCE: Union Carbide Corp; Catalyst C-271: Acute Toxicity and Irritancy Testing Using the Rat (Peroral & Inhalation Toxicity) and the Rabbit (Cutaneous & Eye Tests); 08/24/93; EPA Document No. 89-930000176; Fiche No. OTS0538306] **UNREVIEWED** [HSDB] EXPERT JUDGEMENT: Appears to be a eye corrosive as standard test uses 0.1 ml not the 0.01 ml used in this test. Therefore the effects are expected to be enhanced so classified as an eye corrosive rather than an eye irritant",,"JP_CHRIP, NZ_CCID",2,CN(C)CCN(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J34.745K,J-GLOBAL,CN(C)CCN(C)C,Train "ChemSkin: Isopropyl myristate EU_REACH: isopropyl myristate",,110-27-0,NC,"ChemSkin: https://doi.org/10.3390/toxics9110314 EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16077/7/4/2/?documentUUID=ced703af-f120-4c1f-bea9-59e0b6a33326","ChemSkin: Experimental study (OECD TG 404) EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,"ChemSkin, EU_REACH",2,CCCCCCCCCCCCCC(=O)OC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/8042,PubChem,CCCCCCCCCCCCCC(=O)OC(C)C,Train "EU_REACH: 2,6-difluoro-3-(propane-1-sulfonamido)benzoic acid",,1103234-56-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8013/7/4/2/?documentUUID=8cf76091-2c73-4919-b6a9-59a7249d0760,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)O)F,https://pubchem.ncbi.nlm.nih.gov/compound/46192923,PubChem,CCCS(=O)(=O)Nc1ccc(F)c(C(=O)O)c1F,Train "EU_REACH: 2-methyl-4,6-bis[(octylsulfanyl)methyl]phenol",,110553-27-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13350/7/4/2/?documentUUID=c5664c74-61e4-4751-a365-e08a272f853b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCSCC1=CC(=C(C(=C1)C)O)CSCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/113646,PubChem,CCCCCCCCSCc1cc(C)c(O)c(CSCCCCCCCC)c1,Train "NZ_CCID: Amylamine","NZ_CCID: N-Pentylamine",110-58-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CCE3EABA-1E70-4D06-A6C1-73A681F66700,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/8060,PubChem,CCCCCN,Train "NZ_CCID: 1,4-Diaminobutane","NZ_CCID: putrescine",110-60-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6FB495BD-EFEE-4F4A-82C5-8BDAD63297AB,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(CCN)CN,https://pubchem.ncbi.nlm.nih.gov/compound/1045,PubChem,NCCCCN,Train "JP_CHRIP: 2-Butyne-1,4-diol KR_NCIS: 2-Butyne-1,4-diol NZ_CCID: 2-Butyne-1,4-diol","JP_CHRIP: 1,4-Butynediol 1,4-Dihydroxy-2-butyne 2-Butynediol But-2-yne-1,4-diol KR_NCIS: Butynediol; But-2-yne-1,4-diol NZ_CCID: 2-BUTYNEDIOL, BIS(HYDROXYMETHYL)ACETYLENE, BUTYNEDIOL",110-65-6,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0026e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B3754F63-18D5-46D6-8120-81E735B4679C","JP_CHRIP: In the rabbit test (OECD TG 404) treated 6 animals with 0.5 g for 4 hours, severe erythema and severe edema within 24 hours, and necrosis within 6 days were noted in all animals. Based on the information, the substance was classified as Category 1. The substance was classified as ""R34"" in the EU classification (EU-Annex I (Access on May 2010)) NZ_CCID: Skin Irritation SPECIES: Rabbit RESULT: Irritating REFERENCE SOURCE: BASF AG Ludwigshafen 73)BASF AG, Abteilung Toxikologie, unveroeffentlichte Untersuchung (XXIII/126), 31.12.1973. [ICULID 2000] R-PHRASE: R 34 Causes burns. [ECB] Eye Irritation SPECIES: Rabbit RESULT: Moderate REFERENCE SOURCE: Journal of Applied Toxicology, Vol. 12, No. 2, pages 113-115, 7 references, 1992. [toxnet]",Provided,"JP_CHRIP, KR_NCIS, NZ_CCID",3,OCC#CCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.098I,J-GLOBAL,OCC#CCO,Train "AU_HCIS: Phenol, isononyl- KR_NCIS: Isononylphenol",,11066-49-2,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5792 KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,"AU_HCIS, KR_NCIS",2,CC(C)CCCCCCC1=CC=CC=C1O,https://pubchem.ncbi.nlm.nih.gov/compound/119757,PubChem,CC(C)CCCCCCc1ccccc1O,Train "NZ_CCID: Butylmethylamine","NZ_CCID: N-Methylbutylamine, N-butylmethylamine",110-68-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C445C8AD-F04B-4CB8-948C-F49B51562D96,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCNC,https://pubchem.ncbi.nlm.nih.gov/compound/8068,PubChem,CCCCNC,Train "NZ_CCID: 2-(Ethylamino) ethanol",,110-73-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D4C3AAF5-BE47-48D2-90B9-62EEFF41DECA,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCNCCO,https://pubchem.ncbi.nlm.nih.gov/compound/8072,PubChem,CCNCCO,Train "AU_HCIS: piperazine JP_CHRIP: Piperazine NZ_CCID: Piperazine","AU_HCIS: [liquid] JP_CHRIP: 1,4-Diazacyclohexane 1,4-Diethylenediamine Antiren Diethyleneimine Hexahydropirazine",110-85-0,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3552 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-meti-0015e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7CAEF84F-55E5-4F70-833F-89CA4277EB87","JP_CHRIP: There is a report that in a skin irritation test (OECD TG404) with rabbits, as a result of a semi-occlusive application of this substance (50% aqueous solution) for 4 hours, severe erythema and necrosis were observed (EU-RAR (2005)). In addition, there is a report that in another skin irritation test with rats or mice, necrosis on the application site was observed after a 4 hour-application of this substance (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), DFGOT Vol. 9 (1998)). From the above, it was classified in Category 1. Besides, this substance was classified as ""Skin. Corr. 1B H314"" in EU CLP classification (ECHA CL Inventory (Access on September 2015)). NZ_CCID: Skin Irritation SPECIES: Rabbit RESULT: Corrosive REFERENCE SOURCE: (BASF, 1984). Prepared by the National Chemicals Inspectorate, Sweden. Based on the EU Risk Assessment Report (RAR) on piperazine. [ECB] R PHRASE: R 34 [N-Class) Eye Irritation R PHRASE: R 34 [N-Class)",Provided,"AU_HCIS, JP_CHRIP, NZ_CCID",3,C1CNCCN1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.981J,J-GLOBAL,C1CNCCN1,Train "AU_HCIS: piperidine JP_CHRIP: piperidine NZ_CCID: Piperidine","JP_CHRIP: Azacyclohexane Hexahydropyridine Pentamethyleneimine NZ_CCID: Azacyclohexane, Cyclopentimine, Cypentil, Hexahydropyridine, Hexazane, Pentamethyleneimine, Pentamethylenimine, Perhydropyridine, Pyridine, hexahydro-",110-89-4,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3555 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0169e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/56281F0D-7408-4FB6-A95C-3022A12B8D5E","JP_CHRIP: In the study using 6 rabbits, necrosis was observed in all test animals (PATTY (5th, 2001)). In other animal tests, the substance was reported to have a corrosive effect (HSDB (2008)). Furthermore, in human accident cases, severe epithelial damage and chemical burns were reported with the substance in contact with skin for no longer than 3 minutes (PATTY (5th, 2001)). Based on this information on animals and humans, the substance was classified into Category 1. Its pH = 12.6 (20degC, 100 g/L) (GESTIS (accessed in November 2008)) and it is rated as R34 in the EU classification. NZ_CCID: Skin Irritation SPECIES: Human RESULT: In an accidental case of skin exposure, third degree burns developed after only 3 min of skin contact. REFERENCE SOURCE: [Peer Reviewed] [Snyder, R. (ed.). Ethyl Brownings Toxicity and Metabolism of Industrial Solvents. 2nd ed. Volume II: Nitrogen and Phosphorus Solvents. Amsterdam-New York-Oxford: Elsevier, 1990. 255] [HSDB] UN CLASS: 8 PG I Eye Irritation SPECIES: Rabbit RESULT: Severe damage with permanent corneal injury. REFERENCE SOURCE: [Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963. 2197]**PEER REVIEWED** [HSDB]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,C1CCNCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.884C,J-GLOBAL,C1CCNCC1,Train "AU_HCIS: morpholine EU_REACH: morpholine JP_CHRIP: Morpholine NZ_CCID: Morpholine","JP_CHRIP: Diethylene oximide Tetrahydro-1,4-oxazine tetrahydro-1,4-oxazine [synonym:morpholine] NZ_CCID: 1-Oxa-4-azacyclohexane, 2H-1,4-Oxazine, tetrahydro-, 4H-1,4-Oxazine, tetrahydro-, Diethylene imidoxide, Diethylene oximide, Diethyleneimide oxide, Diethylenimide oxide, Drewamine, Tetrahydro-1,4-oxazine, Tetrahydro-p-oxazine, p-Isoxazine, tetrahydro-",110-91-8,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3091 EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13364/7/4/2/?documentUUID=b5fbf61e-b34d-454d-90ce-c03f3e99c9d0 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2042e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E3D2089C-2B17-4F66-B6D3-AD8AA873BB6E","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: Based on the description that this substance is corrosive to the human skin (SIDS (2015)), and multiple test reports that necrosis occurred due to the application of this substance in skin irritation tests with rabbits (EHC 179 (1996), IARC 47 (1989), ACGIH (7th, 2001), PATTY (6th, 2012), SIDS (2015)), it was classified in Category 1. Besides, in the EU CLP classification, this substance was classified as ""Skin Corr. 1B"" (ECHA CL Inventory (Access on June 2017)). NZ_CCID: Skin Irritation UNCLASS: UN PG 1 R PHRASE: R 34 [iuclid 2000] Eye Irritation SPECIES: Rabbit RESULT: Severe REFERENCE SOURCE: American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1-1918- (29,1363,1946) [RTECS]",Provided,"AU_HCIS, EU_REACH, JP_CHRIP, NZ_CCID",4,C1COCCN1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.453H,J-GLOBAL,C1COCCN1,Train "NZ_CCID: 1-Propanamine, 2-methyl-N-(2-methylpropyl)-","NZ_CCID: Diisobutylamine",110-96-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E0FADC70-DC8C-43B3-B549-0A727A41A55F,"NZ_CCID: Skin Irritation REMARK: UN 2361 Class 3.0;Sub Risk 8; PG III Eye Irritation SPECIES: RESULT: Irritating REFERENCE SOURCE: Review by Thomas (1990) Ethyl Brownings Toxicity and Metabolism of Industrial Solvents. REMARK: UN has classified as sub-risk 8 - corrosive. EXPERT JUDGEMENT: This is probably a severe eye irritant, like many other secondary aliphatic amines.",,NZ_CCID,1,CC(C)CNCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/8085,PubChem,CC(C)CNCC(C)C,Train "JP_CHRIP: 1,1'-iminodipropan-2-ol; di-isopropanolamine","JP_CHRIP: 1,1'-Iminodi-2-propanol Bis(2-propanol) amine diisopropanolamine DIPA",110-97-4,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0170e.html,"JP_CHRIP: There are several reports that the application of the substance to abraded or intact sites of rabbit skin caused moderate or slight hyperemia (IUCLID (2000); HSDB (2006)), or the application to abraded sites caused moderate denaturation (IUCLID (2000); HSDB (2006)). Furthermore, in Draize tests using rabbits, application of undiluted test substance to intact sites on the abdomens of rabbits caused irreversible, severe necrosis at several sites (HSDB (2006)). Thus the substance was classified into Category 1.",,JP_CHRIP,1,CC(O)CNCC(C)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.102K,J-GLOBAL,CC(O)CNCC(C)O,Train "JP_CHRIP: heptanoic acid NZ_CCID: Heptanoic acid","JP_CHRIP: Enanthic acid n-Heptoic acid n-Heptylic acid",111-14-8,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0171e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AB329A3C-A115-48A2-9A1B-217426CCA37F","JP_CHRIP: Rabbits were exposed to the substance for 4 hours, and as a result, treated subjects, as a whole, were graded 5.6 on a scale of 1 to 8 of the primary irritation index, indicating that the substance is corrosive (Patty 5th, 2001). Based on these results, the substance was classified into Category 1. It is rated as R34 in the EU classification (equivalent to Category 1B or 1C) (EU-Annex 1, accessed in November 2008). NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CCCCCCC(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.985B,J-GLOBAL,CCCCCCC(=O)O,Train "EU_REACH: [6-(dimethylamino)hexyl]dimethylamine",,111-18-2,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11920/7/4/2/?documentUUID=abaa9300-517a-409f-854a-5cf660535b57,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C)CCCCCCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/8097,PubChem,CN(C)CCCCCCN(C)C,Train "NZ_CCID: Sebacoyl dichloride",,111-19-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/667545F7-4B26-4C4C-9D45-F80090947A96,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(CCCCC(=O)Cl)CCCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/66072,PubChem,O=C(Cl)CCCCCCCCC(=O)Cl,Train "EU_REACH: tetraethenylsilane",,1112-55-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24943/7/4/2/?documentUUID=5dd459b7-008e-4a43-a735-65d92c8bd0d5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=C[Si](C=C)(C=C)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/66188,PubChem,C=C[Si](C=C)(C=C)C=C,Train "NZ_CCID: Hexylamine US_HSDB: 1-Hexylamine",,111-26-2,Cat 1,"NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D7A42524-7B09-4069-BC4C-81B932E204B0 US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8444","NZ_CCID: Skin Irritation R PHRASE: R 35 [Company Data] Eye Irritation R PHRASE: R 35 [Company Data]",,"NZ_CCID, US_HSDB",2,CCCCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/8102,PubChem,CCCCCCN,Train "JP_CHRIP: Glutaraldehyde KR_NCIS: Glutaraldehyde NZ_CCID: Pentanedial, (glutaraldehyde) US_HSDB: Glutaraldehyde","JP_CHRIP: Glutaraldehyde 1,5-pentanedial 1,5-Pentanedial (50% solution) Glutaral glutardialdehyde Glutaric dialdehyde Pentanedial KR_NCIS: 1,5-pentanedial; 1,3-diformylpropane; Glutaral; Glutardialdehyde; Glutaric dialdehyde NZ_CCID: 1,5-Pentanedial, Glutaral, Glutaraldehyde, Glutardialdehyde, Glutaric acid dialdehyde, Glutaric dialdehyde, Pentanedial",111-30-8,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2008.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B4DEED8F-54FD-4CBB-A0B9-656446DBE6FB US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/949","JP_CHRIP: 【分類根拠】 （１）～（４）より、区分1Bとした。 【根拠データ】 （１）本物質は実験動物の皮膚に対して25％以上の水溶液で刺激性を示す。ヒトの皮膚に付着すると、発赤、水疱を生じるほか、のどや鼻粘膜への刺激症状がみられる。皮膚炎等の防止策として厚生労働省は作業環境気中濃度の最大値の目安を0.05 ppm に設定している（厚労省 リスク評価書 (2015)）。 （２）ウサギ（n=6）を用いた皮膚刺激性試験（OECD TG 404、GLP、4時間適用、10日観察）において、適用後24/48/72h後の紅斑スコアの平均は2.8、浮腫スコアの平均は2.6であり、10日後の観察でも壊死と剥離が認められ回復性はみられなかった。並行して実施した1時間ばく露群ではばく露後に生存した5例のうち2例で壊死、4例で皮膚剥離がみられ、3分ばく露群では1例で軽度の紅斑がみられたとの報告がある（ECHA RAC Opinion (2014)、CLH Report (2013)）。 （３）ウサギ（n=4）を用いた皮膚刺激性試験（4時間適用、8日観察）において、50％水溶液を適用した場合、8日後に壊死、紅斑及び浮腫が認められ、非可逆的な影響であった。また、ウサギ（n=2）を用いた皮膚刺激性試験（50％水溶液を1時間適用、8日観察）では8日後に紅斑及び浮腫を伴う重度の痂皮脱落が認められ、回復性はみられず、ウサギを用いた皮膚刺激性試験（50％水溶液を3分間適用、8日観察）では浮腫はみられず、8日後に痂皮がみられたとの報告がある（ECHA RAC Opinion (2014)、CLH Report (2013)）。 （４）ウサギ（n=5）を用いた皮膚刺激性試験（OECD TG 404相当、半閉塞）において、24％溶液適用群1例について、3分間適用し24時間観察したところ腐食性はみられなかったが、1時間または4時間適用し24時間観察したところ腐食性がみられた。15％溶液適用群1例について、3分間または1時間適用し72時間観察したところ腐食性はみられなかったが、4時間適用し72時間観察したところ腐食性がみられた。4％溶液適用群3例について、4時間適用し14日間観察したところ重度の浮腫がみられた（紅斑・痂皮スコア：3.3/2.7/2.7、浮腫スコア：4/2/3）との報告がある（REACH登録情報 （Accessed July 2021)）。 【参考データ等】 （５）本物質は、平成8年労働省告示第33号（平成25年厚生労働省告示第316号により改正）において、労働基準法施行規則別表第一の二第四号1の厚生労働大臣が指定する単体たる化学物質及び化合物（合金を含む。）に「グルタルアルデヒド」として指定されており、本物質にさらされる業務による、特定の症状又は障害を主たる症状又は障害とする疾病（皮膚障害、前眼部障害又は気道障害）が、業務上の疾病として定められている。 NZ_CCID: Skin Irritation R PHRASE: R 34 [IUCLID 2000] [NCLASS] Eye Irritation SPECIES: RESULT: A 0.1% solution of GA is not irritating to the eye; the threshold for conjunctival irritation is 0.2% and for corneal injury it is 1.0%. Eye injury is moderate at 2% and severe at > or =5%. REFERENCE SOURCE: Ballantyne B, Jordan SL. Applied Toxicology Group, Union Carbide Corporation, 39 Old Ridgebury Road, Danbury, CT 06817-0001, USA. J Appl Toxicol 2001 Mar-Apr;21(2):131-51 [MEDLINE] SPECIES: Rabbit RESULT: ...A 25% aq solution on rabbit eyes, caused severe injury, graded 9 on a scale of 10. A 1% solution quickly abolishes the b-wave of the rabbit retina in vitro. REFERENCE SOURCE: Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986. 462 **PEER REVIEWED** [HSDB]",Provided,"JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",4,O=CCCCC=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.454F,J-GLOBAL,O=CCCCC=O,Train "JP_CHRIP: 1-Isocyanatobutane","JP_CHRIP: 1-Isocyanatobutane",111-36-4,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0006e.html,"JP_CHRIP: After occlusive application of 0.5 mL of an undiluted test substance to rabbit ears for 15 or 30 minutes, effects became more serious and the skin was perforated in 1 to 2 days. Surface skin scaling was observed at the end of observation period of 7 days. On the basis of the evaluation as ""highly corrosive"" (SIDS (2005)), it was classified in Category 1.",,JP_CHRIP,1,CCCCN=C=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J36.974H,J-GLOBAL,CCCCN=C=O,Train "AU_HCIS: 1,2-Ethanediamine, N-(2-aminoethyl)- JP_CHRIP: N-(2-Aminoethyl)-1,2-ethanediamine; Diethylenetriamine NZ_CCID: Diethylene triamine","AU_HCIS: diethylenetriamine DETA ancamine DETA 3-azapentane-1.5-diamine 2,2'-iminobis(ethanamine) JP_CHRIP: 3-Azapentane-1,5-diamine Bis(2-aminoethyl)amine DETA N-(2-Aminoethyl)-1,2-ethanediamine NZ_CCID: 1,2-Ethanediamine, N-(2-aminoethyl)-, 1,4,7-Triazaheptane, 1,5-Diamino-3-azapentane, 2-(2-Aminoethylamino)ethylamine, 3-Azapentane-1,5-diamine, Bis(2-aminoethyl)amine, Diethylenetriamine, N,N-Bis(2-aminoethyl)amine, N-(2-Aminoethyl)-1,2-ethanediamine",111-40-0,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=7 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-2028e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EB07CFC3-E1E7-4577-894F-87F4DD9E9498","JP_CHRIP: Strong corrosivity or corrosivity is described as health effects in humans (Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)) and the results of skin irritation tests with rabbits (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), SIDS (2002)). Furthermore, this substance is classified in ""C; R34"" in EU DSD classification and ""Skin Corr. 1B H314"" in EU CLP classification. It was classified in Category 1 based on the above information. NZ_CCID: Skin Irritation SPECIES: Rabbit RESULT: Highly corrosive. REFERENCE SOURCE: Dow Benelux N. V. Terneuzen (55)(55) Anonym.: Report of Union Carbide Corporation, 27.6.1983 [IUCLID 2000] REMARK: EC Classification: Highly corrosive (causes severe burns) Eye Irritation SPECIES: Rabbit RESULT: Highly corrosive REFERENCE SOURCE: Dow Benelux N. V. Terneuzen (75)(75) Hollingworth, R.L. (1951). Report of The Dow Chemical Company, 13.8. 1951. [IUCLID 2000]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,NCCNCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.108J,J-GLOBAL,NCCNCCN,Train "JP_CHRIP: N-(2-Aminoethyl)-2-aminoethanol NZ_CCID: 2-(2-Aminoethylamino) ethanol","JP_CHRIP: 2-(2-aminoethylamino)ethanol Ethanol, 2-[(2-aminoethyl)amino]- N-(2-aminoethyl)-2-aminoethanol NZ_CCID: N-aminoethylethanolamine",111-41-1,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0081e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4E713A4E-89DE-41C3-8C21-DDA1A6910DC0","JP_CHRIP: In a test by a semi-occlusive application of 0.5 mL of undiluted this substance to the rabbit skin, necrosis occurred in 2/2 animals after a 4-hour application and 1/4 animals after a 1-hour application, and full-thickness skin necrosis was confirmed by pathological examination (SIDS (2008)). And full-thickness skin necrosis was also observed after a 4-hour or 1-hour application in another test by an occlusive application of 0.5 mL of undiluted this substance to the rabbit skin, and it was judged as corrosive (SIDS (2008)), but only minor irritation was noted after a 3-minute application. Therefore, it was classified in Category 1B. Besides, it was classified in C: R34 in EU classification (EC-JRC (ESIS) (Access on Aug. 2012)). NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,NCCNCCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.188F,J-GLOBAL,NCCNCCO,Train "JP_CHRIP: 2,2'-thiodiethanol; thiodiglycol","JP_CHRIP: 2,2'-Thiodiethanol Di(2-hydroxyethyl) sulfide Diethanolsulfide Thiodiethylene glycol Thiodiglycol",111-48-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0039e.html,"JP_CHRIP: Skin irritation tests using rabbits (complied with OECD guideline 404) concluded that the substance was not an irritant, based on the observation of slight erythema (score 1) in 1 of 3 treated rabbits (SIDS (2004)). From these results, the substance was classified into ""Not classified"" (also ""Not classified"" in the United Nations classification).",Provided,JP_CHRIP,1,OCCSCCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.988G,J-GLOBAL,OCCSCCO,Train "JP_CHRIP: Hexahydro-1H-azepin NZ_CCID: Hexamethyleneimine","JP_CHRIP: Hexamethylenimine",111-49-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0103e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/ED5CDB33-85DF-4F51-A46F-8D601369484F","JP_CHRIP: Since the undiluted substance was dermally corrosive, producing an intact scab after 14 days by occluded application to the skin for 24-hour in an acute dermal toxicity test in rabbits (HSDB (2003)), the substance was classified into Category 1. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,C1CCCNCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J22.113I,J-GLOBAL,C1CCCNCC1,Train "NZ_CCID: Adipoyl dichloride",,111-50-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7BEAA83C-BC76-4D17-9707-03DC183E614A,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(CCC(=O)Cl)CC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/61034,PubChem,O=C(Cl)CCCCC(=O)Cl,Train "EU_REACH: 1,4-diethyl 2-acetylbutanedioate",,1115-30-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18399/7/4/2/?documentUUID=bd427c12-7b4b-4bf3-89ea-99a4ec6eea8d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)CC(C(=O)C)C(=O)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/66197,PubChem,CCOC(=O)CC(C(C)=O)C(=O)OCC,Train "NZ_CCID: Triisobutylamine","NZ_CCID: 1-Propanamine, 2-methyl-N,N-bis(2-methylpropyl)-",1116-40-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A4406924-5585-431C-ABD5-5B23859590CD,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CC(C)CN(CC(C)C)CC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/14222,PubChem,CC(C)CN(CC(C)C)CC(C)C,Train "EU_REACH: heptylamine NZ_CCID: 1-Heptanamine",,111-68-2,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21376/7/4/2/?documentUUID=da3261b7-0bd2-491d-a298-98121729689b NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3FDCD552-1EEB-4D8C-B7AE-6CC5FBF7A118","EU_REACH: Experimental study (OECD TG 404, GLP) NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",Provided,"EU_REACH, NZ_CCID",2,CCCCCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/8127,PubChem,CCCCCCCN,Train "JP_CHRIP: 2-(2-Methoxyethoxy)ethanol (synonym: Diethylene glycol monomethyl ether)","JP_CHRIP: DEGME",111-77-3,NC,JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2009.html,"JP_CHRIP: 【分類根拠】 （１）、（２）より、区分に該当しない。 【根拠データ】 （１）ウサギ（n=6）を用いた皮膚刺激性試験（OECD TG 404 相当、閉塞、4時間適用、72時間観察）において、皮膚刺激性はみられなかった（紅斑・痂皮スコア：0/0/0/0/0/0、浮腫スコア：0/0/0/0/0/0）との報告がある（EU RAR (2000)、AICIS IMAP (2013)、REACH登録情報 (Accessed July 2021)、Government of Canada, Hazadous Substance Assessement (2020)）。 （２）ウサギ、モルモットを用いたDraize試験において、軽度の皮膚刺激性を示したとの報告がある（Government of Canada, Hazadous Substance Assessement (2020)）。",Provided,JP_CHRIP,1,COCCOCCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.114D,J-GLOBAL,COCCOCCO,Train "EU_REACH: methyl undec-10-enoate",,111-81-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10072/7/4/2/?documentUUID=37d10816-0ce5-4a40-bd98-6a2464773183,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)CCCCCCCCC=C,https://pubchem.ncbi.nlm.nih.gov/compound/8138,PubChem,C=CCCCCCCCCC(=O)OC,Train "EU_REACH: octan-1-amine JP_CHRIP: 1-Octanamine NZ_CCID: Octylamine","NZ_CCID: n-octylamine",111-86-4,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16566/7/4/2/?documentUUID=987529f3-c3c1-4ff0-bb68-5322adbe51d1 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0007e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/49BD61B3-14EF-4370-8306-3D0EC143C390","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: It was classified in Category 1 because it is reported that in an acute toxicity test by dermal administration to rabbits, necrosis was observed at the sites of application of this substance in the 200 mg/kg dose group during a 7-day observation period (RTECS (1997): the original article, United States Environmental Protection Agency, Office of Pesticides and Toxic Substances: 8EHQ-1085-0569), and it is also described that 1-octanamine is a severe skin irritant (PATTY (5th, 2001)). NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",Provided,"EU_REACH, JP_CHRIP, NZ_CCID",3,CCCCCCCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.115B,J-GLOBAL,CCCCCCCCN,Train "JP_CHRIP: di-n-butylamine; KR_NCIS: Di-n-butylamine","JP_CHRIP: di-n-butylamine N-Butyl-1-butanamine n-Dibutylamine KR_NCIS: Dibutylamine; N-Butyl-1-butanamine; N-Butylbutan-1-amine",111-92-2,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0173e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","JP_CHRIP: The classification was based on the description that the substance is found to be corrosive in Draize tests using rabbits (IUCLID (2000)).",,"JP_CHRIP, KR_NCIS",2,CCCCNCCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.886J,J-GLOBAL,CCCCNCCCC,Train "EU_REACH: 1,5-dimethyl pentanedioate",,1119-40-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5377/7/4/2/?documentUUID=e021234e-30db-497e-80e1-0dcf4c27823b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)CCCC(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/14242,PubChem,COC(=O)CCCC(=O)OC,Train "NZ_CCID: 5-Chlorovaleric acid",,1119-46-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/42FACE71-DC2A-4576-AC67-F1EB3D13E280,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(CCCl)CC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/14244,PubChem,O=C(O)CCCCCl,Train "JP_CHRIP: Thiacloprid",,111988-49-9,NC,JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2010.html,"JP_CHRIP: 【分類根拠】 （１）～（３）より、区分に該当しない。 【根拠データ】 （１）ウサギを用いた皮膚刺激性試験において、皮膚刺激性はみられなかったとの報告がある（食安委 農薬評価書 (2019)）。 （２）ウサギ（n=3）を用いた皮膚刺激性試験（OECD TG 404）において、非常に軽度の紅斑が全例でみられたが、適用後72時間以内にすべて回復した（紅斑・痂皮スコア：1/1/0、浮腫スコア：0/0/0）との報告がある（ECHA RAC Opinion (2015)、CLH Report (2013)）。 （３）本物質はウサギに対して皮膚刺激物ではない（JMPR Report (2006)）。",Provided,JP_CHRIP,1,Clc1ccc(CN2CCSC2=NC#N)cn1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.459.101J,J-GLOBAL,N#CN=C1SCCN1Cc1ccc(Cl)nc1,Train "NZ_CCID: Dioctylamine",,1120-48-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/107CAA4D-F41F-4FB7-B069-E122EE5D080C,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCCCCCCCNCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/3094,PubChem,CCCCCCCCNCCCCCCCC,Train "NZ_CCID: Trichlorooctadecylsilane","NZ_CCID: octadecyltrichlorosilane",112-04-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CB495C1C-ED21-40AF-BE7C-03ADFFD919A2,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCCCCCCCCCCCCCC[Si](Cl)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/8157,PubChem,CCCCCCCCCCCCCCCCCC[Si](Cl)(Cl)Cl,Train "EU_REACH: (R)-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide",,112101-81-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30158/7/4/2/?documentUUID=6427986c-cc44-4f80-96e2-adb0c20a46d7,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@H](CC1=CC(=C(C=C1)OC)S(=O)(=O)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/10060387,PubChem,COc1ccc(C[C@@H](C)N)cc1S(N)(=O)=O,Train "NZ_CCID: Decanoyl chloride",,112-13-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1D2D0EAE-9D70-48EC-A7CF-137C20E661EF,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCCCCCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/66982,PubChem,CCCCCCCCCC(=O)Cl,Train "NZ_CCID: Lauroyl chloride",,112-16-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/219A2202-4420-421E-B98B-AB2B24BD2676,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCCCCCCCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/8166,PubChem,CCCCCCCCCCCC(=O)Cl,Train "AU_HCIS: 1-Dodecanamine, N,N-dimethyl- EU_REACH: dodecyldimethylamine JP_CHRIP: N,N-Dimethyldodecan-1-ylamine NZ_CCID: Dimethyldodecylamine","JP_CHRIP: dodecyldimethylamine lauryldimethylamine N,N-dimethyldodecylamine NZ_CCID: 1-Dodecanamine, N,N-dimethyl-, Genamin LA 302 D, N,N-dimethyl-1-dodecanamine, N,N-dimethyldodecylamine, N,N-dimethyllaurylamine, armeen dm-12d, dodecyldimethylamine, lauryldimethylamine, monolauryl dimethylamine, n-dodecyldimethylamine, n-lauryldimethylamine",112-18-5,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5000 EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14856/7/4/2/?documentUUID=dbc54309-bb73-4af9-810d-214ad44bea6c JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-meti-2005e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7FB884CC-31F2-4F06-9F08-0082B34C0E72","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: [Rationale for the Classification] Based on (1)-(3), it was classified in Category 1 according to the GHS Classification Guidance for the Japanese Government. Besides, although Category 1A is suggested from the information in (2), sub-categorization was not conducted since the information in (3) was also obtained. [Evidence Data] (1) It is reported that this substance is severely irritating to human skins (Environmental Risk Assessment for Chemical Substances vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010)). (2) There is a report that in a skin irritation test (OECD TG 404) with rabbits, both of the two products with different purities (the content of this substance: 95%, 70%) were corrosive after application for 4 hours or 3 minutes (SIDS (2004)). (3) There are reports that in the skin irritation test (OECD TG 404) with rabbits, in all of two tests showing corrosivity and one test showing irritation, in which a 3-minute or 4-hour application was followed by a 1-hour observation, the erythema scores were lower than 4, and the criteria of Category 1A were not met (NICNAS IMAP (Accessed Oct. 2018)). NZ_CCID: Skin Irritation SPECIES: Rabbit RESULT: Corrosive REFERENCE SOURCE: Hoechst AG Frankfurt 80 Hoechst AG Frankfurt/Main [IUCLID 2000] REMARK: EC Classification: Corrosive (causes burns) Eye Irritation SPECIES: Rabbit RESULT: Moderately irritating REFERENCE SOURCE: Hoechst AG Frankfurt 80 Hoechst AG Frankfurt/Main [IUCLID 2000] REMARK: EC Classification: Irritating.",Provided,"AU_HCIS, EU_REACH, JP_CHRIP, NZ_CCID",4,CCCCCCCCCCCCN(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J27.950A,J-GLOBAL,CCCCCCCCCCCCN(C)C,Train "NZ_CCID: Nonylamine","NZ_CCID: n-nonylamine",112-20-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5347AC53-41F6-4BD4-A6CE-2D570D252F4E,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCCCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/16215,PubChem,CCCCCCCCCN,Train "AU_HCIS: 3,6-diazaoctanethylenediamin JP_CHRIP: 3,6-diazaoctanethylenediamin; triethylenetetramine NZ_CCID: Triethylenetetramine","AU_HCIS: triethylenetetramine 1,2-Ethanediamine, N,N'-bis(2-aminoethyl)- trientine JP_CHRIP: 3,6-Diazaoctane-1,8-diamine trientine Triethylenetetramine NZ_CCID: 1,4,7,10-Tetraazadecane, 1,8-Diamino-3,6-diazaoctane, 3,6-Diazaoctane-1,8-diamine, Araldite hardener HY 951, TETA, Tecza, Trien, Trientine",112-24-3,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1203 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0042e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/914A6290-E1D7-4845-A4B9-FE061289559A","JP_CHRIP: In rabbit skin tests, the substance caused not only erythema and edema, but also necrosis in several tests (SIDS (1998)). Thus, the substance was classified into Category 1. NZ_CCID: Skin Irritation SPECIES: Rabbit RESULT: Skin Irritation Grade 6. 6 = more necrosis from undiluted, less than edema from 10%. REFERENCE SOURCE: [Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963. 2046]**PEER REVIEWED** [HSDB] R PHRASE: R 34 [N-CLASS] Eye Irritation R-PHRASE: R 34 [N-CLASS]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,NCCNCCNCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.120I,J-GLOBAL,NCCNCCNCCN,Train "EU_REACH: 2,6,6-trimethylcyclohex-2-ene-1,4-dione",,1125-21-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6062/7/4/2/?documentUUID=25e23680-51ca-4220-b652-161f64b27635,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=O)CC(C1=O)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/62374,PubChem,CC1=CC(=O)CC(C)(C)C1=O,Train "AU_HCIS: 3,6,9-triazaundecamethylenediamine JP_CHRIP: 3,6,9-triazaundecamethylenediamine; tetraethylenepentamine NZ_CCID: Tetraethylenepentamine","AU_HCIS: tetraethylenepentamine 1,2-Ethanediamine, N-(2-aminoethyl)-N'-[2-[(2-aminoethyl)amino]ethyl]- JP_CHRIP: 1,11-Diamino-3,6,9-triazaundecane 3,6,9-Triazaundecane-1,11-diamine TEPA Tetraethylenepentamine Tetrene",112-57-2,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4545 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0044e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8F36AABA-11B0-4CDB-A52A-5BA52444ED0D","JP_CHRIP: In several rabbit tests (Draize tests, etc.), exposure to the undiluted substance for 4 hours resulted in necrosis in half or more animals and the substance was concluded to be corrosive (SIDS (accessed in June 2008)). In addition, its EU Risk Phrase is ""R34: corrosive"" and its pH is >= 11.5. From these, the substance was classified into Category 1. NZ_CCID: Skin Irritation R PHRASE: R 34 [IUCLID 2000] Eye Irritation SPECIES: Rabbit RESULT: Severe burns. REFERENCE SOURCE: [Lefaux, R. Practical Toxicology of Plastics. Cleveland: CRC Press Inc., 1968. 166]**PEER REVIEWED**[HSDB]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,NCCNCCNCCNCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.129B,J-GLOBAL,NCCNCCNCCNCCN,Train "NZ_CCID: Tetradecanoyl chloride",,112-64-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9FCDB945-04F4-47A2-9B24-32ABD85A6C15,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCCCCCCCCCCCCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/66986,PubChem,CCCCCCCCCCCCCC(=O)Cl,Train "NZ_CCID: Palmitoyl chloride",,112-67-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CB410A6C-0C28-4EF3-9D2C-8C11B6F17EED,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCCCCCCCCCCCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/8206,PubChem,CCCCCCCCCCCCCCCC(=O)Cl,Train "EU_REACH: 1-[2-(2-butoxyethoxy)ethoxy]butane",,112-73-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5839/7/4/2/?documentUUID=a75bca5d-9bd3-4b29-b27a-e3e218dce05d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOCCOCCOCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/8210,PubChem,CCCCOCCOCCOCCCC,Train "NZ_CCID: Oleoyl chloride",,112-77-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/11029E3A-A995-4626-9CAA-E84C7EEE9196,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCCCC/C=C\CCCCCCCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/5364783,PubChem,CCCCCCCC/C=C\CCCCCCCC(=O)Cl,Train "AU_HCIS: (Z)-octadec-9-enylamine JP_CHRIP: (Z)-9-Octadecen-1-amine; oleylamine NZ_CCID: Oleyl amine","AU_HCIS: 9-Octadecen-1-amine, (Z)- JP_CHRIP: (Z)-9-Octadecene-1-amine (Z)-Octadec-9-en-1-ylamine",112-90-3,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4780 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0083e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4D4A053D-3B5F-44F8-A629-523C7F2A07FE","JP_CHRIP: It was classified in Category 1 because it is reported that necrosis was noted, and average Draize scores were 4.0 for both erythema and edema in a test by a 4-hour semi-occlusive application of 0.5 mL of the test substance to the rabbit skin (OECD TG 404), which was terminated for humane reasons (EU-RAR (2008)), and in another test with rabbits and almost the same test conditions (OECD TG 404), average Draize scores after 24, 48, and 72 hours for erythema and edema were 4.0, 3.7, and 3.7, and corrosive effects (eschar, scabbing, scarring) were observed at the application sites of all animals (EU-RAR (2008)). NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",Provided,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CCCCCCCC/C=C\CCCCCCCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J59.382F,J-GLOBAL,CCCCCCCC/C=C\CCCCCCCCN,Train "JP_CHRIP: Guanidine","JP_CHRIP: Guanidine monohydrochloride",113-00-8,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0084e.html,"JP_CHRIP: It was classified in Category 1 because it is described that the pH of a 20% aqueous solution of this substance was 13.5 (Ullmanns (E) (6th, 2003)).",,JP_CHRIP,1,NC(=N)N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.462G,J-GLOBAL,N=C(N)N,Train "EU_REACH: 3-morpholin-4-ylpropane-1-sulfonic acid",,1132-61-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21270/7/4/2/?documentUUID=5edc7b1e-e258-4b3e-8b0d-bc755d6eecc9,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1COCCN1CCCS(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/70807,PubChem,O=S(=O)(O)CCCN1CCOCC1,Train "EU_REACH: (2R)-5-cyclohexyl-2-methylpentan-1-ol; (2S)-5-cyclohexyl-2-methylpentan-1-ol",,1141487-54-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12526/7/4/2/?documentUUID=50687e9b-c1de-4dda-80ab-b6f75ef31d4c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CCCC1CCCCC1)CO,https://pubchem.ncbi.nlm.nih.gov/compound/44192644,PubChem,CC(CO)CCCC1CCCCC1,Train "EU_REACH: 4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile",,114772-54-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2706/7/4/2/?documentUUID=073f47ac-933f-43d6-b011-aad39b702593,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C(=C1)C#N)C2=CC=C(C=C2)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/1501912,PubChem,N#Cc1ccccc1-c1ccc(CBr)cc1,Train "NZ_CCID: Tribromoacetaldehyde","NZ_CCID: Bromal",115-17-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FC7AC182-A3F5-48B4-A4DA-47EBD00497E9,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C(=O)C(Br)(Br)Br,https://pubchem.ncbi.nlm.nih.gov/compound/8256,PubChem,O=CC(Br)(Br)Br,Train "JP_CHRIP: Trichloroethylsilane NZ_CCID: Trichloroethylsilane",,115-21-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0091e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5E1AF554-0C60-4EA6-8917-5928949022D5","JP_CHRIP: Based on results that attacked region blanches and blisters after application to the skin of rabbits and that the substance is strong irritant (HSDB (2003)), the substance was classified into Category 1. NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,"JP_CHRIP, NZ_CCID",2,CC[Si](Cl)(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J36.827J,J-GLOBAL,CC[Si](Cl)(Cl)Cl,Train "EU_REACH: N-(3-{1,1,1,5,5,5-hexamethyl-3-[(trimethylsilyl)oxy]trisiloxan-3-yl}propyl)prop-2-enamide",,115258-10-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1845/7/4/2/?documentUUID=859bfad8-8741-4310-bd3c-3f32866035fa,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](C)(C)O[Si](CCCNC(=O)C=C)(O[Si](C)(C)C)O[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/16050379,PubChem,C=CC(=O)NCCC[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C,Train "EU_REACH: 1-benzyl-N-phenylpiperidin-4-amine",,1155-56-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23031/7/4/2/?documentUUID=45d50916-b094-4316-8c2b-d926cce09407,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CN(CCC1NC2=CC=CC=C2)CC3=CC=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/70865,PubChem,c1ccc(CN2CCC(Nc3ccccc3)CC2)cc1,Train "EU_REACH: triphenyl phosphate JP_CHRIP: Triphenyl Phosphate","JP_CHRIP: Phosphoric acid, triphenyl ester TPP Triphenylphosphate",115-86-6,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15972/7/4/2/?documentUUID=abff226e-be6f-4b87-ab1f-c427d9b5e967 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-1000e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: From description that irritation was not admitted in the test applied to the skin of the rat for 4 hours on DFGOT (2 vol. 1991) and ACGIH (7th, 2001), it was carried out the outside of Category.",Provided,"EU_REACH, JP_CHRIP",2,O=P(Oc1ccccc1)(Oc1ccccc1)Oc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.469D,J-GLOBAL,O=P(Oc1ccccc1)(Oc1ccccc1)Oc1ccccc1,Train "JP_CHRIP: Tris(2-chloroethyl) phosphate","JP_CHRIP: Ethanol, 2-chloro-, phosphate (3:1) TCEP Tri(beta-chloroethyl) phosphate Tris(2-chloroethyl) orthophosphate tris(2-chloroethyl)phosphate",115-96-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-meti-0012e.html,"JP_CHRIP: In two reports on skin irritation tests (OECD TG 404) using rabbits, it is reported that slight erythema was observed, but this resolved within 24 hours (EU-RAR (2009)). In addition, it is described that in a skin irritation test using rabbits, as the result of applying 0.5 mL of this substance for 4 hours under a semi-occlusive dressing, slight erythema was observed in all animals on Day 1 after application, but there were no signs of irritation (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), EHC 209 (1998)). From the above, this substance was classified as ""Not classified"" (Category 3 in UN GHS classification). Based on the added information, the category was changed according to the GHS Classification Guidance for the Japanese Government.",Provided,JP_CHRIP,1,ClCCOP(=O)(OCCCl)OCCCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.095I,J-GLOBAL,O=P(OCCCl)(OCCCl)OCCCl,Train "EU_REACH: methyl 1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylate",,1160293-25-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26465/7/4/2/?documentUUID=83b2bbd2-662e-42ac-9734-8761663d1e87,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1=CC2=C(CC(=O)N2C(=O)CCl)C=C1,https://pubchem.ncbi.nlm.nih.gov/compound/42634136,PubChem,COC(=O)c1ccc2c(c1)N(C(=O)CCl)C(=O)C2,Train "EU_REACH: hexachloropropan-2-one",,116-16-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17343/7/4/2/?documentUUID=0dc9628b-4cad-4b06-af67-d81b5e5cd83d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(=O)(C(Cl)(Cl)Cl)C(Cl)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/8303,PubChem,O=C(C(Cl)(Cl)Cl)C(Cl)(Cl)Cl,Train "NZ_CCID: 2-Methylbutyric acid",,116-53-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7F2DD93B-C132-4BFB-8960-83C145F6A991,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCC(C)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/8314,PubChem,CCC(C)C(=O)O,Train "EU_REACH: 1,4-bis(mesitylamino)anthraquinone",,116-75-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5736/7/4/2/?documentUUID=db4b62d3-46d7-4889-97ef-71a724c00b96,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C(=C1)C)NC2=C3C(=C(C=C2)NC4=C(C=C(C=C4C)C)C)C(=O)C5=CC=CC=C5C3=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/61042,PubChem,Cc1cc(C)c(Nc2ccc(Nc3c(C)cc(C)cc3C)c3c2C(=O)c2ccccc2C3=O)c(C)c1,Train "EU_REACH: methyl (3E)-3-[methoxy(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate",,1168150-46-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27187/7/4/2/?documentUUID=cc2dbdf9-a473-473a-841b-57550a10a424,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CO/C(=C/1\C2=C(C=C(C=C2)C(=O)OC)NC1=O)/C3=CC=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/42634134,PubChem,COC(=O)c1ccc2c(c1)NC(=O)/C2=C(/OC)c1ccccc1,Train "EU_REACH: 4-chloro-1,3-dihydro-2-benzofuran-1,3-dione",,117-21-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11567/7/4/2/?documentUUID=e6c0a0d5-dd5c-4032-b7e6-1a4b0a021f1e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC2=C(C(=C1)Cl)C(=O)OC2=O,https://pubchem.ncbi.nlm.nih.gov/compound/67014,PubChem,O=C1OC(=O)c2c(Cl)cccc21,Train "EU_REACH: 2-(naphthalene-2-sulfonamido)benzoic acid",,117309-52-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23982/7/4/2/?documentUUID=01d7ab5c-6f8a-47e9-a11a-2d8469c71732,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)NC3=CC=CC=C3C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/4798771,PubChem,O=C(O)c1ccccc1NS(=O)(=O)c1ccc2ccccc2c1,Train "EU_REACH: methyl (2E)-3-methoxy-2-[2-({[6-(trifluoromethyl)pyridin-2-yl]oxy}methyl)phenyl]acrylate",,117428-22-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21001/7/4/2/?documentUUID=349e85bc-f90d-4892-8207-a003afb591e1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CO/C=C(\C1=CC=CC=C1COC2=CC=CC(=N2)C(F)(F)F)/C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/11285653,PubChem,CO/C=C(/C(=O)OC)c1ccccc1COc1cccc(C(F)(F)F)n1,Train "EU_REACH: Methyl-2-(2-chloromethylphenyl)-3-methoxy-2-acrylate",,117428-95-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11725/7/4/2/?documentUUID=e967bddc-7d24-4f00-8e87-91e69767ed1d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CO/C=C(/C1=CC=CC=C1CCl)\C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/10130990,PubChem,CO/C=C(\C(=O)OC)c1ccccc1CCl,Train "EU_REACH: 2-[2-(carboxymethyl)phenoxy]-3,4-dimethylbenzoic acid",,117570-93-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2727/7/4/2/?documentUUID=edda16c9-f94b-4696-a119-5846d400d09d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C(=C(C=C1)C(=O)O)OC2=CC=CC=C2CC(=O)O)C,https://pubchem.ncbi.nlm.nih.gov/compound/14885557,PubChem,Cc1ccc(C(=O)O)c(Oc2ccccc2CC(=O)O)c1C,Train "JP_CHRIP: Bis(2-ethylhexyl) phthalate","JP_CHRIP: Bis(2-ethylhexyl) phthalate Bis-(2-ethylhexyl)phthalate DEHP Di(2-ethylhexy)phthalate Di(2-ethylhexyl) phthalate Di(2-ethylhexyl)phthalate di-2-ethylhexyl phthalate Diethylhexyl phthalate dioctyl benzene-1,2-dicarboxylate Dioctyl phthalate Dioctylphthalate DOP; DEHP",117-81-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2081e.html,"JP_CHRIP: There are 2 reports of skin irritation tests (OECD TG 404) with rabbits. In one study, neither erythema nor edema was observed, and the irritation score was 0 (EU-RAR (2003)). In the other study, although slight erythema (3/3 animals) at 1 hour after application, significant erythema (1/3 animals) at 24 hours after application, and slight erythema (3/3 of the animals) at 48 hours after application were observed, they resolved 8 days after application, therefore, it was judged to be slightly irritating (EU-RAR (2003)). In addition, in another skin irritation test with rabbits (FDA recommended method, GLP-compliant), after 24-hour application of this substance, slight to moderate skin reaction was observed but this disappeared after 48 hours, therefore, it was judged to be slightly irritating (EU-RAR (2003)). Moreover, there is a report that in humans, the undiluted liquid of this substance was applied occlusively to the backs of 23 subjects for 7 days and reapplied on the 10th day, and no skin reaction was observed (EU-RAR (2003)). From the above results, it was classified as ""Not classified"" (Category 3 in UN GHS classification). The category was changed according to the revised GHS classification guidance for the Japanese government.",Provided,JP_CHRIP,1,CCCCC(CC)COC(=O)c1ccccc1C(=O)OCC(CC)CCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.909B,J-GLOBAL,CCCCC(CC)COC(=O)c1ccccc1C(=O)OCC(CC)CCCC,Train "EU_REACH: N-(3,5-dichloro-4-ethyl-2-hydroxyphenyl)hexadecanamide",,117827-06-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6149/7/4/2/?documentUUID=b0b6bcec-57f4-4f69-ae45-859a4752f0f9,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCC(=O)NC1=CC(=C(C(=C1O)Cl)CC)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/14344747,PubChem,CCCCCCCCCCCCCCCC(=O)Nc1cc(Cl)c(CC)c(Cl)c1O,Train "EU_REACH: 3-[(3R)-3-amino-2,3,4,9-tetrahydro-1H-carbazol-9-yl]propanoic acid",,1182722-58-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12204/7/4/2/?documentUUID=ce3e9b8c-c03f-4805-8ac7-cdc05d5bf9eb,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC2=C(C[C@@H]1N)C3=CC=CC=C3N2CCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/46928273,PubChem,N[C@@H]1CCc2c(c3ccccc3n2CCC(=O)O)C1,Train "EU_REACH: trans-5-butyl-2-(3',3'',4'',5''-tetrafluoro-1,1':4',1''-terphenyl-4-yl)-1,3-dioxane",,1182844-21-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29749/7/4/2/?documentUUID=681ee1e5-13fa-4a70-a8de-02f217f299fa,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC1COC(OC1)C2=CC=C(C=C2)C3=CC(=C(C=C3)C4=CC(=C(C(=C4)F)F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/132042669,PubChem,CCCCC1COC(c2ccc(-c3ccc(-c4cc(F)c(F)c(F)c4)c(F)c3)cc2)OC1,Train "EU_REACH: hexaphenoxy-1,3,5,2λ⁵,4λ⁵,6λ⁵-triazatriphosphinine",,1184-10-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30500/7/4/2/?documentUUID=2b6d5add-28a9-4284-a647-9d182b19f902,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)OP2(=NP(=NP(=N2)(OC3=CC=CC=C3)OC4=CC=CC=C4)(OC5=CC=CC=C5)OC6=CC=CC=C6)OC7=CC=CC=C7,https://pubchem.ncbi.nlm.nih.gov/compound/136917,PubChem,c1ccc(OP2(Oc3ccccc3)=NP(Oc3ccccc3)(Oc3ccccc3)=NP(Oc3ccccc3)(Oc3ccccc3)=N2)cc1,Train "EU_REACH: 5-chloro-1,3-dihydro-2-benzofuran-1,3-dione",,118-45-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12546/7/4/2/?documentUUID=d508a43e-401a-4f86-9f4a-9acb086633a2,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC2=C(C=C1Cl)C(=O)OC2=O,https://pubchem.ncbi.nlm.nih.gov/compound/67044,PubChem,O=C1OC(=O)c2cc(Cl)ccc21,Train "EU_REACH: 4-(3,5-dichlorobenzamido)-3-hydroxybenzoic acid",,1184581-58-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27410/7/4/2/?documentUUID=6c2ec289-2390-485b-bdce-b97314f46345,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C=C1C(=O)O)O)NC(=O)C2=CC(=CC(=C2)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/60825179,PubChem,O=C(O)c1ccc(NC(=O)c2cc(Cl)cc(Cl)c2)c(O)c1,Train "EU_REACH: 1,4-diethyl 2-(2-oxopropyl)butanedioate",,1187-74-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1510/7/4/2/?documentUUID=d1ca5732-c110-4546-8901-d12c33bd3213,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)CC(CC(=O)C)C(=O)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/5463816,PubChem,CCOC(=O)CC(CC(C)=O)C(=O)OCC,Train "EU_REACH: 1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone",,1190865-44-1,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32348/7/4/2/?documentUUID=cbd17be7-29ac-45a8-ba17-20b98a1c2040,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(C=C(C(=C1Cl)F)Cl)C(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/75530023,PubChem,O=C(c1cc(Cl)c(F)c(Cl)c1)C(F)(F)F,Train "EU_REACH: 3-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzene-1-sulfonic acid",,119-17-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13434/7/4/2/?documentUUID=7af4c05a-40b5-42fd-a96d-e79f14d129dd,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=NN(C(=O)C1)C2=CC(=CC=C2)S(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/67060,PubChem,CC1=NN(c2cccc(S(=O)(=O)O)c2)C(=O)C1,Train "EU_REACH: (3aS,3bR,9aS,9bR,11aS)-9a,11a-dimethyl-8-(morpholin-4-yl)-2-(pyrrolidin-1-yl)-hexadecahydro-1H-cyclopenta[a]phenanthrene-1,7-diol",,119302-20-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7282/7/4/2/?documentUUID=b5120f69-1dfa-4c1c-99c5-7c47137ba9ff,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@]12CC[C@H]3[C@H]([C@@H]1C[C@@H]([C@@H]2O)N4CCCC4)CC[C@@H]5[C@@]3(C[C@@H]([C@H](C5)O)N6CCOCC6)C,https://pubchem.ncbi.nlm.nih.gov/compound/16063873,PubChem,C[C@]12C[C@H](N3CCOCC3)[C@@H](O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](O)[C@@H](N3CCCC3)C[C@@H]12,Train "EU_REACH: 2-benzyl-2-(dimethylamino)-1-[4-(morpholin-4-yl)phenyl]butan-1-one JP_CHRIP: 2-Benzyl-2-(N,N-dimethylamino)-1-(4-morpholinophenyl)butan-1-one",,119313-12-1,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1145/7/4/2/?documentUUID=c308d4e8-3e9a-41c1-a00b-bb2f082bb774 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-0002e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1), (2). [Evidence Data] (1) No skin reactions were observed in a skin irritation test with rabbits according to OECD TG 404 (REACH registration dossier (Access on June 2020)). (2) No skin reactions were seen in a skin irritation test with rabbits according to EU Method B.4 (Acute Toxicity: Dermal Irritation/Corrosion) (REACH registration dossier (Access on June 2020)).",Provided,"EU_REACH, JP_CHRIP",2,CCC(Cc1ccccc1)(N(C)C)C(=O)c1ccc(cc1)N1CCOCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J261.950D,J-GLOBAL,CCC(Cc1ccccc1)(C(=O)c1ccc(N2CCOCC2)cc1)N(C)C,Train "KR_NCIS: 4,6-Dichloropyrimidine",,1193-21-1,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C1=C(N=CN=C1Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/70943,PubChem,Clc1cc(Cl)ncn1,Train "EU_REACH: 6-hydroxypyrimidin-4(3H)-one",,1193-24-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5164/7/4/2/?documentUUID=90eac021-7cb1-48d4-91f4-06f7ce519f18,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(N=CNC1=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/14512,PubChem,O=c1cc(O)nc[nH]1,Train "EU_REACH: 2-(dimethylamino)-2-[(4-methylphenyl)methyl]-1-[4-(morpholin-4-yl)phenyl]butan-1-one",,119344-86-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15616/7/4/2/?documentUUID=055fc99b-f8bb-4064-8461-21392930a973,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(CC1=CC=C(C=C1)C)(C(=O)C2=CC=C(C=C2)N3CCOCC3)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/22019755,PubChem,CCC(Cc1ccc(C)cc1)(C(=O)c1ccc(N2CCOCC2)cc1)N(C)C,Train "JP_CHRIP: 2,6-Dichlorobenzonitrile; Dichlobenil","JP_CHRIP: 2,6-Dichlorobenzonitrile 2,6-Dichlorophenylcyanide DBN",1194-65-6,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2041e.html,"JP_CHRIP: [Rationale for the Classification] Based on (1)-(4), it was classified as ""Not classified."" [Evidence Data] (1) In a skin irritation test in which this substance (85.3% formulation) was administered to rabbits according to EPA TG81-5 (corresponding to OECD TG 404), it is reported not to be a dermal irritant (EPA Pesticide (1998), REACH registration dossier (Access on August 2019)). (2) In a skin irritation test with rabbits, no irritation was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014)). (3) In a skin irritation test with rabbits (4-hour application), the scores 30-60 minutes after application and 24/48/72 hours after were all 0 and no irritation was observed (Agricultural Chemicals Times supplement Vol.10 (Japan Crop Protection Association, 1991)). (4) This substance was not irritating to the skin of rabbits (JMPR (2014)).",Provided,JP_CHRIP,1,Clc1cccc(Cl)c1C#N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.365K,J-GLOBAL,N#Cc1c(Cl)cccc1Cl,Train "EU_REACH: 2-tert-butyl-6-[(3-tert-butyl-2-hydroxy-5-methylphenyl)methyl]-4-methylphenol",,119-47-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/4/2/?documentUUID=acbbd449-9b9e-4a13-8efd-cb8530505947,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C(=C1)C(C)(C)C)O)CC2=C(C(=CC(=C2)C)C(C)(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/8398,PubChem,Cc1cc(Cc2cc(C)cc(C(C)(C)C)c2O)c(O)c(C(C)(C)C)c1,Train "EU_REACH: diphenylmethanone JP_CHRIP: Benzophenone","JP_CHRIP: Benzoylbenzene Diphenyl ketone Phenyl ketone",119-61-9,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13823/7/4/2/?documentUUID=5e9a31d6-89a6-44b3-a490-d1f15501ac72 JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-mhlw-2010.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: 【分類根拠】 （１）より、区分に該当しない。なお、新たな知見に基づき、分類結果を変更した。 【根拠データ】 （１）ウサギ（n=4）を用いた皮膚刺激性試験（OECD TG 404、GLP、2～100％（原液）、半閉塞、4時間適用、72時間観察）において、濃度100％まで皮膚刺激性の徴候は認められなかったとの報告がある（AICIS IMAP (2015)、REACH登録情報 (Accessed Dec. 2021)）。",Provided,"EU_REACH, JP_CHRIP",2,O=C(c1ccccc1)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.481C,J-GLOBAL,O=C(c1ccccc1)c1ccccc1,Train "EU_REACH: 1-[2-chloro-4-(4-chlorophenoxy)phenyl]ethanone",,119851-28-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2113/7/4/2/?documentUUID=3e861be4-4e9e-4d56-89b6-e094e09dbd15,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C1=C(C=C(C=C1)OC2=CC=C(C=C2)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/677479,PubChem,CC(=O)c1ccc(Oc2ccc(Cl)cc2)cc1Cl,Train "KR_NCIS: 3,3'-Dimethoxy-[1,1'-biphenyl]-4,4'-diamine","KR_NCIS: 3,3'-Dimethoxybenzidine",119-90-4,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,COC1=C(C=CC(=C1)C2=CC(=C(C=C2)N)OC)N,https://pubchem.ncbi.nlm.nih.gov/compound/8411,PubChem,COc1cc(-c2ccc(N)c(OC)c2)ccc1N,Train "EU_REACH: 4-(4-hydroxybenzoyloxy)-3-methylphenyl 4-hydroxybenzoate",,119959-84-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33665/7/4/2/?documentUUID=026b0aab-161d-435f-bbdb-6ab724102de8,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=CC(=C1)OC(=O)C2=CC=C(C=C2)O)OC(=O)C3=CC=C(C=C3)O,https://pubchem.ncbi.nlm.nih.gov/compound/10992120,PubChem,Cc1cc(OC(=O)c2ccc(O)cc2)ccc1OC(=O)c1ccc(O)cc1,Train "EU_REACH: 480-680-7",,120128-90-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13705/7/4/2/?documentUUID=1503ef99-75ae-454c-882e-2968022b13ea,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[N+](C)(CCCNC=O)CC(=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/5287757,PubChem,C[N+](C)(CCCNC=O)CC(=O)[O-],Train "EU_REACH: 3-amino-4-methoxy-N-phenylbenzamide",,120-35-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11279/7/4/2/?documentUUID=1b8e5b99-8ae3-4a31-848c-da5b45a24817,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2)N,https://pubchem.ncbi.nlm.nih.gov/compound/8426,PubChem,COc1ccc(C(=O)Nc2ccccc2)cc1N,Train "EU_REACH: benzyl benzoate JP_CHRIP: benzyl benzoate","JP_CHRIP: Benzoic acid, phenylmethyl ester Benzyl benzenecarboxylate",120-51-4,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13634/7/4/2/?documentUUID=f0f6e844-bd09-4c6b-a62d-097bc9b901b2 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0178e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: In Draize tests using rabbits, the average scores of the treated animals that received 4-hour applications of this substance for 3 days were 0 to 1.58 (ECETOC TR 66 (1995)). Based on these results, the substance was classified into the ""Not classified"" category.",Provided,"EU_REACH, JP_CHRIP",2,O=C(OCc1ccccc1)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.327I,J-GLOBAL,O=C(OCc1ccccc1)c1ccccc1,Train "EU_REACH: 2-[2-(benzoyloxy)ethoxy]ethyl benzoate",,120-55-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5156/7/4/2/?documentUUID=b5c20315-fe6b-4262-ad93-9eb0db0cab85,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C(=O)OCCOCCOC(=O)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/8437,PubChem,O=C(OCCOCCOC(=O)c1ccccc1)c1ccccc1,Train "JP_CHRIP: Dimethyl terephthalate","JP_CHRIP: Dimethyl 1,4-benzenedicarboxylate Dimethyl p-phthalate",120-61-6,NC,JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-mhlw-2007.html,"JP_CHRIP: 【分類根拠】 （１）～（３）より、区分に該当しない（国連分類基準の区分3）。 【根拠データ】 （１）モルモットを用いた皮膚刺激性試験において、軽度の刺激性を示したとの報告がある（NITE初期リスク評価書 (2008)）。 （２）ウサギ（n = 6）を用いた皮膚刺激性試験（OECD TG 404相当、半閉塞、4時間適用、72時間観察）において、皮膚一次刺激指数（PII）は0であった（紅斑・痂皮スコア：0/0/0/0/0/0、浮腫スコア：0/0/0/0/0/0）との報告がある（REACH登録情報 (Accessed Nov. 2021)）。 （３）ウサギを用いた皮膚刺激性試験（4時間適用、24時間観察）において、観察期間中に刺激はみられなかったとの報告がある（産衛学会許容濃度の暫定値の提案理由書 (2020)）。",Provided,JP_CHRIP,1,COC(=O)c1ccc(cc1)C(=O)OC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.003F,J-GLOBAL,COC(=O)c1ccc(C(=O)OC)cc1,Train "EU_REACH: 3-(2-hydroxyethyl)-1,2,3,4-tetrahydroquinazoline-2,4-dione",,1207-75-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22543/7/4/2/?documentUUID=5578c8ff-4520-43d8-837c-8a517c19c62c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)C(=O)N(C(=O)N2)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/71016,PubChem,O=c1[nH]c2ccccc2c(=O)n1CCO,Train "EU_REACH: N-methyl-1-(trans-4-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)methanesulfonamide",,1208319-26-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32698/7/4/2/?documentUUID=5ab3230a-d471-4185-914a-7821f0618c40,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CNS(=O)(=O)CC1CCC(CC1)N(C)C2=NC=NC3=C2C=CN3,https://pubchem.ncbi.nlm.nih.gov/compound/44631938,PubChem,CNS(=O)(=O)CC1CCC(N(C)c2ncnc3[nH]ccc23)CC1,Train "JP_CHRIP: 2,4-Dichlorophenol NZ_CCID: 2,4-Dichlorophenol","JP_CHRIP: 2,4-DCP Phenol, 2,4-dichloro-",120-83-2,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-meti-0013e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/31BDD982-C6FC-4700-A595-FEF5B93A0560","JP_CHRIP: It is reported that strong irreversible necrosis was observed after applying this substance (80% aqueous solution) to rabbit skin for 15 minutes (SIDS (2008)). In addition, many cases of deaths of workers exposed to this substance were reported (SIDS (2008), Environmental Risk Assessment for Chemical Substances (Ministry of the Environment) Vol. 8 (2010)). It is described that contact with only 1% of the body surface may lead to death. From the above, this substance was classified in Category 1. Besides, it is classified as ""Skin Corr. 1B H 314"" in the EU CLP classification (ECHA C&L Inventory (Access on June 2015)). NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,Oc1ccc(Cl)cc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.005B,J-GLOBAL,Oc1ccc(Cl)cc1Cl,Train "KR_NCIS: 1-Methylpyrrolidine",,120-94-5,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CN1CCCC1,https://pubchem.ncbi.nlm.nih.gov/compound/8454,PubChem,CN1CCCC1,Train "EU_REACH: 2-Chloro-1-(1-chlorocyclopropyl)ethanone",,120983-72-4,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/9302/7/4/2/?documentUUID=54bc83d5-8e31-4a70-a1c0-0c26cb0fa45e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC1(C(=O)CCl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/11062580,PubChem,O=C(CCl)C1(Cl)CC1,Train "JP_CHRIP: 2-Methyl-5-nitrobenzenesulfonic acid","JP_CHRIP: 2-methyl-5-nitrobenzenesulfonic acid",121-03-9,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0086e.html,"JP_CHRIP: It is reported that it was moderately irritating in a test in which 20 mg of this substance was applied to the rabbit skin for 24 hours (IUCLID (2000), RTECS (1997)), but it was classified in Category 1 from the knowledge that the pH of an aqueous solution (100 g/L) of this substance was less than 1 (IUCLID (2000)).",,JP_CHRIP,1,Cc1ccc(cc1S(=O)(=O)O)[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J10.070F,J-GLOBAL,Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)O,Train "EU_REACH: 1-ethoxy-2,3-difluorobenzene",,121219-07-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22555/7/4/2/?documentUUID=1ccbfe49-5d7a-476d-82ca-f6177223fe75,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC1=C(C(=CC=C1)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/2782928,PubChem,CCOc1cccc(F)c1F,Train "AU_HCIS: triethylamine JP_CHRIP: Triethylamine KR_NCIS: Triethylamine NZ_CCID: Ethanamine, N,N-diethyl- US_HSDB: TRIETHYLAMINE","AU_HCIS: Ethanamine, N,N-diethyl- JP_CHRIP: N,N-Diethylethanamine KR_NCIS: N,N-Diethylethanamine NZ_CCID: (Diethylamino)ethane, TEA, Triethylamine, n,n-Diethylethanamine",121-44-8,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4580 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0118e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/997D38F8-A52C-4958-84D4-2B474B59B18D US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/896","JP_CHRIP: In a skin irritation test using rabbits under occlusive application for 3 minutes, 1 hour or 4 hours, it was found to be corrosive (DFGOT Vol.13 (1999)). Therefore, this substance was classified in Category 1. NZ_CCID: Skin Irritation R-PHRASE: R 35 Causes severe burns. [IUCLID 2000] Eye Irritation SPECIES: Rabbit RESULT: Strongly alkaline and when drop is applied to the rabbits eye, causes severe injury, graded 9 on a scale of 1 to 10 after 24 hr/ Most severe injuries ahve been rated 10. tests of aq soln on rabbit eyes @ pH 10 and pH 11 indicate injuriousness of triethylamine/ is rated principally to degree of alkalinity. Chronic exposure of rabbits to vapours @ concn as low as 50 ppm in air causes multiple erosions of cornea and conjunctiva in 6 weeks. REFERENCE SOURCE: [Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986. 944]**PEER REVIEWED** [HSDB]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,CCN(CC)CC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.485F,J-GLOBAL,CCN(CC)CC,Train "EU_REACH: 4-methanesulfonyl-2-(trifluoromethyl)benzaldehyde",,1215310-75-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27232/7/4/2/?documentUUID=1d540db8-6860-476c-99e4-1d4927980fc6,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CS(=O)(=O)C1=CC(=C(C=C1)C=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/51342018,PubChem,CS(=O)(=O)c1ccc(C=O)c(C(F)(F)F)c1,Train "EU_REACH: (1r,4r)-N1,N1,N4,N4-tetrakis(2-hydroxyethyl)cyclohexane-1,4-dicarboxamide",,1215841-86-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5440/7/4/2/?documentUUID=37975966-991f-4aa2-9b8c-8b61d1d30bd8,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC(CCC1C(=O)N(CCO)CCO)C(=O)N(CCO)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/58434361,PubChem,O=C(C1CCC(C(=O)N(CCO)CCO)CC1)N(CCO)CCO,Train "NZ_CCID: 4-Acetamidobenzenesulphonyl chloride","NZ_CCID: N-acetylsulfanilyl chloride",121-60-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1ECCEC52-E782-484C-AE66-CBA9069E87F9,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(=O)NC1=CC=C(C=C1)S(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/8481,PubChem,CC(=O)Nc1ccc(S(=O)(=O)Cl)cc1,Train "EU_REACH: 9-[(3,3'-di-tert-butyl-2'-{8,10-dioxa-9-phosphatricyclo[9.4.0.0²,⁷]pentadeca-1(11),2(7),3,5,12,14-hexaen-9-yloxy}-5,5'-dimethoxy-[1,1'-biphenyl]-2-yl)oxy]-8,10-dioxa-9-phosphatricyclo[9.4.0.0²,⁷]pentadeca-1(11),2(7),3,5,12,14-hexaene",,121627-17-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12308/7/4/2/?documentUUID=7c029f5e-a96b-45e4-9a4a-3758f6009c89,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1=CC(=CC(=C1OP2OC3=CC=CC=C3C4=CC=CC=C4O2)C5=C(C(=CC(=C5)OC)C(C)(C)C)OP6OC7=CC=CC=C7C8=CC=CC=C8O6)OC,https://pubchem.ncbi.nlm.nih.gov/compound/10865829,PubChem,COc1cc(-c2cc(OC)cc(C(C)(C)C)c2Op2oc3ccccc3c3ccccc3o2)c(Op2oc3ccccc3c3ccccc3o2)c(C(C)(C)C)c1,Train "AU_HCIS: Benzenesulfonic acid, 4-dodecyl-",,121-65-3,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4887,,,AU_HCIS,1,CCCCCCCCCCCCC1=CC=C(C=C1)S(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/8485,PubChem,CCCCCCCCCCCCc1ccc(S(=O)(=O)O)cc1,Train "EU_REACH: 2,2-dichloro-1-[5-(furan-2-yl)-2,2-dimethyl-1,3-oxazolidin-3-yl]ethan-1-one",,121776-33-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7356/7/4/2/?documentUUID=cedd60ea-7013-42a2-ae58-6debacb290c5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(N(CC(O1)C2=CC=CO2)C(=O)C(Cl)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/86187,PubChem,CC1(C)OC(c2ccco2)CN1C(=O)C(Cl)Cl,Train "JP_CHRIP: Hexahydro-1,3,5-trinitro-1,3,5-triazine (with 15% water, by mass)","JP_CHRIP: 1,3,5-Triaza-1,3,5-trinitrocyclohexane Cyclonite Cyclotrimethylenetrinitramine Hexahydro-1,3,5-trinitro-1,3,5-triazine Hexogen RDX RDX (Royal Demolition Explosive)",121-82-4,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2037e.html,"JP_CHRIP: [Rationale for the Classification] Based on (1), it was classified as ""Not classified."" Besides, the category was changed, since new data were obtained. [Evidence Data] (1) In a skin irritation test with rabbits equivalent or similar to OECD TG 404, the number of animals whose scores were 1 or above consecutively until 72 hours was only one out of six, and all of the scores for other animals were zero at 72 hours (REACH registration dossier (Access on August 2019)). [Reference Data, etc.] (2) There are a report that no irritation was observed in a human patch test (dose unknown) and a report that dermatitis was induced (ATSDR (2012)). (3) Slight erythema was induced in guinea pigs exposed to this substance (1,000 mg/kg) (ATSDR (2012)). (4) Dermatitis was induced in rabbits by exposure to this substance in acetone (27 mg/kg), in cyclohexane (37.5 mg/kg), or in DMSO (165 mg/kg) (ATSDR (2012)).",Provided,JP_CHRIP,1,[O-][N+](=O)N1CN(CN(C1)[N+](=O)[O-])[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.346E,J-GLOBAL,O=[N+]([O-])N1CN([N+](=O)[O-])CN([N+](=O)[O-])C1,Train "EU_REACH: 2-chloro-1-methyl-4-nitrobenzene",,121-86-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1542/7/4/2/?documentUUID=efe61ba0-d389-4a51-9bb7-08d4fd5a0b37,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)[N+](=O)[O-])Cl,https://pubchem.ncbi.nlm.nih.gov/compound/8491,PubChem,Cc1ccc([N+](=O)[O-])cc1Cl,Train "NZ_CCID: 4-Nitrobenzoyl chloride",,122-04-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1F70CA0D-4102-4E3F-A3EC-2619F1D31B9D,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1C(=O)Cl)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/8502,PubChem,O=C(Cl)c1ccc([N+](=O)[O-])cc1,Train "EU_REACH: O,O-dimethyl O-3-methyl-4-nitrophenyl phosphorothioate JP_CHRIP: O,O-Dimethyl-O-(3-methyl-4-nitrophenyl) thiophosphate [Fenitrothion]","JP_CHRIP: Fenitrothion O,O'-dimethyl-O-(3-methyl-4-nitrophenyl) monothiophosphate O,O'-Dimethyl-O-(3-methyl-4-nitrophenyl)phosphorothioate O,O-Dimethyl O-3-methyl-4-nitrophenyl phosphorothioate O,O-Dimethyl O-4-nitro-m-tolyl phosphorothioate O,O-Dimethyl O-4-nitro-m-tolyl thiophosphate O,O-Dimethyl-O-(3-methyl-4-nitrophenyl) thiophosphate Phosphorothioic acid, O,O-dimethyl O-(3-methyl-4-nitrophenyl) ester",122-14-5,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27782/7/4/2/?documentUUID=efd959b1-f517-4b3e-b2ee-82f05036fee8 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2076e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: Based on a report that skin irritation was not observed in a skin irritation test with rabbits (EHC 133 (1992), Risk Assessment Report (Pesticides and Veterinary Medicinal Products) (Food Safety Commission of Japan, 2014)), it was classified as ""Not classified."" The category was revised based on the information obtained in this research.",Provided,"EU_REACH, JP_CHRIP",2,COP(=S)(OC)Oc1ccc(c(C)c1)[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.492I,J-GLOBAL,COP(=S)(OC)Oc1ccc([N+](=O)[O-])c(C)c1,Train "EU_REACH: 3-hydroxy-4-{[2-methoxy-5-(phenylcarbamoyl)phenyl]diazenyl}-N-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-2-naphthamide",,12225-06-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13914/7/4/2/?documentUUID=b3d41585-a0af-42b5-bcd4-723bc1697f3c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COc1ccc(cc1N\N=C2/C(=O)C(=Cc3ccccc23)C(=O)Nc4ccc5NC(=O)Nc5c4)C(=O)Nc6ccccc6,https://cactus.nci.nih.gov/chemical/structure/12225-06-8/smiles,CACTUS,COc1ccc(C(=O)Nc2ccccc2)cc1N/N=C1\C(=O)C(C(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)=Cc2ccccc21,Train "EU_REACH: N-(4-chloro-2,5-dimethoxyphenyl)-2-{[2,5-dimethoxy-4-(phenylsulfamoyl)phenyl]diazenyl}-3-oxobutanamide",,12225-18-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11078/7/4/2/?documentUUID=286f124c-4bfa-47eb-b7d5-81bc70834824,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC(=C(C=C1OC)Cl)OC)N=NC2=CC(=C(C=C2OC)S(=O)(=O)NC3=CC=CC=C3)OC,https://pubchem.ncbi.nlm.nih.gov/compound/61559,PubChem,COc1cc(NC(=O)C(N=Nc2cc(OC)c(S(=O)(=O)Nc3ccccc3)cc2OC)C(C)=O)c(OC)cc1Cl,Train "EU_REACH: N-(4-acetamidophenyl)-4-[(5-carbamoyl-2-chlorophenyl)diazenyl]-3-hydroxy-2-naphthamide",,12236-64-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10624/7/4/2/?documentUUID=6892ac2e-658d-4d03-a82d-fde7d2bfdedd,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)NC1=CC=C(C=C1)NC(=O)C2=CC3=CC=CC=C3C(=C2O)N=NC4=C(C=CC(=C4)C(=O)N)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/82995,PubChem,CC(=O)Nc1ccc(NC(=O)c2cc3ccccc3c(N=Nc3cc(C(N)=O)ccc3Cl)c2O)cc1,Train "JP_CHRIP: Triethoxymethane","JP_CHRIP: Ethyl orthoformate",122-51-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0105e.html,"JP_CHRIP: Based on a result of ""not irritating"" in a rabbit test (OECD TG404 (GLP)) (IUCLID (2000)), the substance was classified as ""Not classified"".",Provided,JP_CHRIP,1,CCOC(OCC)OCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.533F,J-GLOBAL,CCOC(OCC)OCC,Train "JP_CHRIP: Triethyl phosphite","JP_CHRIP: Phosphorous acid, triethyl ester",122-52-1,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0005e.html,"JP_CHRIP: Based on results of ""slightly irritating"" (PDII: 1.4) in a rabbit test (OECD TG404) (SIDS (2003)) and ""mildly irritating"" (PDII: 1.7) in another rabbit Draize test (SIDS (2003)), the substance was classified as ""Not classified"" in JIS Classification (correspond to Category 3 in GHS classification).",Provided,JP_CHRIP,1,CCOP(OCC)OCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.007I,J-GLOBAL,CCOP(OCC)OCC,Train "NZ_CCID: Cyclohexanone peroxide, 30-60%, 30-60% dibutyl phthalate, 10-30% ethyl acetate","NZ_CCID: Cyclohexanone peroxide",12262-58-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BFC446A9-880E-4187-8708-5DF6B980A43A,"NZ_CCID: Skin Irritation R-PHRASE: R 34 Causes Burns. [N-Class] Eye Irritation SPECIES: Rabbit RESULT: Severe REFERENCE SOURCE: [Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25, 1951-75. (8,25,1958)] [RTECS]",,NZ_CCID,1,C1CCC(CC1)(O)OOC2(CCCCC2)OO,https://pubchem.ncbi.nlm.nih.gov/compound/6521,PubChem,OOC1(OOC2(O)CCCCC2)CCCCC1,Train "EU_REACH: 4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyl methacrylate",,1228350-17-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18171/7/4/2/?documentUUID=ba69bd97-7c66-452a-888c-5fbb792423ca,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OCCCC(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/19098704,PubChem,C=C(C)C(=O)OCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train "EU_REACH: 3-octyl-1-[4-({4-[(octylcarbamoyl)amino]phenyl}methyl)phenyl]urea",,122886-55-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16583/7/4/2/?documentUUID=a47fcfce-f39a-4f64-a226-911cb22f8936,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCNC(=O)NC1=CC=C(C=C1)CC2=CC=C(C=C2)NC(=O)NCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/14299396,PubChem,CCCCCCCCNC(=O)Nc1ccc(Cc2ccc(NC(=O)NCCCCCCCC)cc2)cc1,Train "EU_REACH: 4-(4-iodo-1H-pyrazol-1-yl)piperidine",,1229457-94-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5524/7/4/2/?documentUUID=3d776ce8-229b-4ae8-ba55-b87b733b64b1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CNCCC1N2C=C(C=N2)I,https://pubchem.ncbi.nlm.nih.gov/compound/53256681,PubChem,Ic1cnn(C2CCNCC2)c1,Train "EU_REACH: 3-morpholin-4-ylpropan-1-amine NZ_CCID: 4-Morpholinepropanamine","NZ_CCID: (3-Aminopropyl)morpholine, 1-Amino-3-morpholinopropane, 3-Morpholinopropanamine, 3-Morpholinopropylamine, 4-(3-Aminopropyl)morpholine, Morpholine, 4-(3-aminopropyl)- (8CI), Morpholine, 4-aminopropyl-, Morpholine, N-aminopropyl-, N-(3-Aminopropyl)morpholine, N-Aminopropylmorpholine, gamma-Morpholinopropylamine",123-00-2,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24742/7/4/2/?documentUUID=6d8b456b-10a7-4a35-9942-a0fe7f5ef67a NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4EAC4513-4CEC-4A78-9CB8-F5B140AB94F3","EU_REACH: Experimental study (OECD TG 404, GLP) NZ_CCID: Skin Irritation SPECIES: Rabbit RESULT: Extremely irritating/ Corrosive REFERENCE SOURCE: (http://www.huntsman.com/performance_chemicals/Media/APM.pdf) Eye Irritation SPECIES: Rabbit RESULT: Extremely irritating/ Corrosive REFERENCE SOURCE: (http://www.huntsman.com/performance_chemicals/Media/APM.pdf)",Provided,"EU_REACH, NZ_CCID",2,C1COCCN1CCCN,https://pubchem.ncbi.nlm.nih.gov/compound/61055,PubChem,NCCCN1CCOCC1,Train "EU_REACH: 14,14',15,15'-tetradehydro-7,7'-spirobi[dibenzo[b,g][1,9,4,6]dioxadiazacyclododecine]",,1231148-36-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6054/7/4/2/?documentUUID=378da222-d36f-4739-a917-65aa83fe80d1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C2(COC3=CC=CC=C3N=C=NC4=CC=CC=C4O1)COC5=CC=CC=C5N=C=NC6=CC=CC=C6OC2,https://pubchem.ncbi.nlm.nih.gov/compound/58434418,PubChem,C1=Nc2ccccc2OCC2(COc3ccccc3N=1)COc1ccccc1N=C=Nc1ccccc1OC2,Train "EU_REACH: 4-[(3-carboxypropanoyl)peroxy]-4-oxobutanoic acid",,123-23-9,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24749/7/4/2/?documentUUID=84c9b78d-2fa5-49a9-95c5-086fa74344d0,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CC(=O)OOC(=O)CCC(=O)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/31248,PubChem,O=C(O)CCC(=O)OOC(=O)CCC(=O)O,Train "EU_REACH: 1,4-diethyl butanedioate",,123-25-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27981/7/4/2/?documentUUID=c266f723-64cd-466a-b644-0e18b70e9dfe,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)CCC(=O)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/31249,PubChem,CCOC(=O)CCC(=O)OCC,Train "EU_REACH: 1-Ethoxy-2,3-difluoro-4-[trans-4-(trans-4-propylcyclohexyl)-cyclohexyl]-benzene",,123560-48-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24097/7/4/2/?documentUUID=d78f8475-f561-4868-b086-04179e005276,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1CCC(CC1)C2CCC(CC2)C3=C(C(=C(C=C3)OCC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/11417199,PubChem,CCCC1CCC(C2CCC(c3ccc(OCC)c(F)c3F)CC2)CC1,Train "EU_REACH: pyrrolidine-2,5-dione",,123-56-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30168/7/4/2/?documentUUID=c07eafc2-8204-49b3-85e7-7ef86ff93357,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC(=O)NC1=O,https://pubchem.ncbi.nlm.nih.gov/compound/11439,PubChem,O=C1CCC(=O)N1,Train "JP_CHRIP: propionic anhydride NZ_CCID: Propionic anhydride","JP_CHRIP: Methylacetic anhydride Propanoic acid anhydride Propanoic anhydride propionic anhydride",123-62-6,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0184e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F56DF2CD-F535-4A20-A1B3-6D5965DDA08A","JP_CHRIP: This substance is reported to cause skin corrosion or burns in humans (HSDB (2005), SITTIG vol. 2). In addition, it is rated as C; R34 in the EU classification (EU-Annex 1 (accessed in November 2008)). Thus, the substance was classified into Category 1. As additional background information, propionic anhydride, in contact with water, produces propionic acid (ICSC (J) (2005)), which is skin corrosive (ICSC (J) (2005)). (Regarding propionic acid, see NITE ID926.) NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CCC(=O)OC(=O)CC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.542E,J-GLOBAL,CCC(=O)OC(=O)CC,Train "JP_CHRIP: butyraldehyde","JP_CHRIP: Butyraldehyde Butanal Butyl aldehyde n-butyraldehyde",123-72-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0106e.html,"JP_CHRIP: Since it is documented that in two tests using rabbits (both tests are in compliant with OECD TG 404, GLP), the substance was either not irritating or slightly irritating (IUCLID (2000)), it was classified into the ""Not classified"" category using JIS classification criteria (Category 3 in UN classification).",Provided,JP_CHRIP,1,CCCC=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.501A,J-GLOBAL,CCCC=O,Train "JP_CHRIP: Pyrrolidine KR_NCIS: Pyrrolidine NZ_CCID: Pyrrolidine","JP_CHRIP: Azacyclopentane Pyrrole, tetrahydro NZ_CCID: Tetrahydropyrrole",123-75-1,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0074e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F6002A7A-04AB-47FD-A266-AF872A32B1F5","JP_CHRIP: Based on a result of ""a severe skin irritant"" in a skin primary irritation test with rabbits (PATTY (5th, 2001)), a result that the tails of mice dipped into undiluted test substance showed first signs of necrosis after 54 seconds and then it is corrosive to the skin and data of pH 12.9 (100 g/L, 20 degC) (GESTIS (access on Aug. 2009)), the substance was classified into Category 1. NZ_CCID: Skin Irritation SPECIES: RESULT: Corrosive. REFERENCE SOURCE: KHB/PD Eye Irritation SPECIES: RESULT: Corrosive REFERENCE SOURCE:",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,C1CCNC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.931I,J-GLOBAL,C1CCNC1,Train "JP_CHRIP: Hexamethylenediamine NZ_CCID: 1,6-Hexanediamine","JP_CHRIP: 1,6-Diaminohexane 1,6-Hexanediamine Hexamethylenediamine Hexane-1,6-diamine HMD(A) NZ_CCID: 1,6-Diamino-n-hexane, 1,6-Diaminohexane, 1,6-Hexamethylenediamine, 1,6-Hexylenediamine, Hexamethylene diamine, Hexamethylenediamine",124-09-4,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-2015e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F6435420-3F0B-4A95-8599-0022404C4DDB","JP_CHRIP: Pain reactions were observed within one minute after application of the test substance containing 85% of this substance to the skin of three rabbits, and erythema with small vesicles was seen immediately after the removal of the patch (after 15 minutes) (SIDS (Access on Oct. 2011)). Furthermore, as a result of the 24-hour application of the powders of the test substance to three rabbits, the irritation score was 8 for all three animals at all observation points (maximum 8), and it was judged as corrosive (USEPA/HPV (2003), corresponding to List 1). From the above, it was classified in Category 1. Besides, it is described that the pH of this substance (100 g/L an aqueous solution) was 12.4 (GESTIS (Access on Sept. 2011)). NZ_CCID: Skin Irritation SPECIES: Rabbit RESULT: Corrosive REFERENCE SOURCE: BASF AG Ludwigshafen. (53) TSCATS, OTS0520783, Doc. I. D. 86-890001277, 07-24-89, Hoechst Celanese Corporationy (54) TSCATS, OTS0534489, Doc. I. D. 86-920000433, 12-03-91, Hoechst Celanese Corporation [IUCLID 2000] R PHRASE: R 34 [IUCLID 2000] Eye Irritation SPECIES: Rabbit RESULT: Severe opacity of cornea, hemorrhages on conjunctiva and iris REFERENCE SOURCE: BASF AG Ludwigshafen. (129) TSCATS, OTS0555377, Doc. I. D. 88-920009060, 09-10-92, E.I. Dupont de Nemours and Co [IUCLID 2000]",,"JP_CHRIP, NZ_CCID",2,NCCCCCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J10.055B,J-GLOBAL,NCCCCCCN,Train "JP_CHRIP: Decane",,124-18-5,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0078e.html,"JP_CHRIP: Based on a result of ""slightly irritating"" in a rabbit test (OECD TG404 (GLP)) (IUCLID (2000)) and ""slightly irritating"" in another rabbit test (Directive 84/449/EEC, B.4) where the maximum mean score was 1.5 for erythema at 72-hour after application (IUCLID (2000)), the substance was classified as ""Not classified"" in JIS Classification (correspond to Category 3 in GHS classification). As relevant information, there is a report of ""no irritation "" in tests with human subjects where a 30% solution was applied to skin for 24-hour (HSDB (2003)).",Provided,JP_CHRIP,1,CCCCCCCCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.505D,J-GLOBAL,CCCCCCCCCC,Train "NZ_CCID: Spermidine","NZ_CCID: 1,4-Butanediamine, N-(3-aminopropyl)-",124-20-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/78FC3E9A-504D-4135-882F-9B11A27528A6,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C(CCNCCCN)CN,https://pubchem.ncbi.nlm.nih.gov/compound/1102,PubChem,NCCCCNCCCN,Train "AU_HCIS: 1-Dodecanamine NZ_CCID: Dodecylamine",,124-22-1,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4989 NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/ACE84350-B2BD-4C79-8E03-49C02023B0CA","NZ_CCID: Skin Irritation R PHRASE: R 35 [Company Data] Eye Irritation R PHRASE: R 35 [Company Data]",,"AU_HCIS, NZ_CCID",2,CCCCCCCCCCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/13583,PubChem,CCCCCCCCCCCCN,Train "JP_CHRIP: Methanesulfonyl chloride KR_NCIS: Methanesulfonyl chloride NZ_CCID: Methanesulphonyl chloride","JP_CHRIP: Mesyl chloride Methanesulfonic acid chloride Methylsulfonyl chloride",124-63-0,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0192e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C421ED1A-ED97-4CDF-BB8F-5F1D253D1A2C","JP_CHRIP: Based on results of corrosive in a mouse skin irritation test (anesthetized tail method) (PATTY (5th, 2001), IUCLID (2000)), the substance was classified into Category 1. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,CS(=O)(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.507K,J-GLOBAL,CS(=O)(=O)Cl,Train "KR_NCIS: Dichloroethenylmethylsilane NZ_CCID: Dichloromethylvinylsilane","KR_NCIS: Silane, dichloroethenylmethyl-",124-70-9,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/44F35E4F-D870-4604-8EEF-F4AC49BCA2DB","NZ_CCID: Skin Irritation UN # 2985 UN CLASS: 8 PG II Eye Irritation R PHRASE: R 35 [Company Data] UN # 2985 UN CLASS: 8 PG II",,"KR_NCIS, NZ_CCID",2,C[Si](C=C)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/31299,PubChem,C=C[Si](C)(Cl)Cl,Train "EU_REACH: 1-ethoxy-2,3-difluoro-4-{4-[(1s,4r)-4-propylcyclohexyl]cyclohex-1-en-1-yl}benzene",,124728-62-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/28115/7/4/2/?documentUUID=d9de185c-dc76-4288-9053-eea823683a25,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1CCC(CC1)C2CCC(=CC2)C3=C(C(=C(C=C3)OCC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/11462604,PubChem,CCCC1CCC(C2CC=C(c3ccc(OCC)c(F)c3F)CC2)CC1,Train "EU_REACH: 1-ethoxy-2,3-difluoro-4-[trans-4-(trans-4-pentylcyclohexyl)-cyclohexyl-benzene",,124728-81-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21421/7/4/2/?documentUUID=de581aad-b394-443c-90ed-a478f6e17bb1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCC1CCC(CC1)C2CCC(CC2)C3=C(C(=C(C=C3)OCC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/22184033,PubChem,CCCCCC1CCC(C2CCC(c3ccc(OCC)c(F)c3F)CC2)CC1,Train "EU_REACH: methyl 3-(chloromethyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylate",,1247712-63-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17001/7/4/2/?documentUUID=18573f79-4aba-4ba3-85fe-2755da42eaf6,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1=CC(=NN1C2=C(C=CC=N2)Cl)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/49850068,PubChem,COC(=O)c1cc(CCl)nn1-c1ncccc1Cl,Train "EU_REACH: 2-methyl-4-(4-{[6-(prop-2-enoyloxy)hexyl]oxy}benzoyloxy)phenyl 4-{[6-(prop-2-enoyloxy)hexyl]oxy}benzoate",,125248-71-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24921/7/4/2/?documentUUID=c888a066-b4bf-4edd-8645-38c4f1e624a6,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=CC(=C1)OC(=O)C2=CC=C(C=C2)OCCCCCCOC(=O)C=C)OC(=O)C3=CC=C(C=C3)OCCCCCCOC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/21183256,PubChem,C=CC(=O)OCCCCCCOc1ccc(C(=O)Oc2ccc(OC(=O)c3ccc(OCCCCCCOC(=O)C=C)cc3)c(C)c2)cc1,Train "EU_REACH: propan-2-yl 3-cyclopentyl-1-methyl-1H-indole-6-carboxylate",,1253789-90-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5917/7/4/2/?documentUUID=aca17551-1744-4edc-b31b-7f6c39810c6b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)OC(=O)C1=CC2=C(C=C1)C(=CN2C)C3CCCC3,https://pubchem.ncbi.nlm.nih.gov/compound/66835544,PubChem,CC(C)OC(=O)c1ccc2c(C3CCCC3)cn(C)c2c1,Train "EU_REACH: propan-2-yl 2-bromo-3-cyclopentyl-1-methyl-1H-indole-6-carboxylate",,1253791-42-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5718/7/4/2/?documentUUID=5cd055a9-4eb1-4578-bc02-8e352ef45e20,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)OC(=O)C1=CC2=C(C=C1)C(=C(N2C)Br)C3CCCC3,https://pubchem.ncbi.nlm.nih.gov/compound/66835853,PubChem,CC(C)OC(=O)c1ccc2c(C3CCCC3)c(Br)n(C)c2c1,Train "EU_REACH: trans-2-[4'-[difluoro(3,4,5-trifluorophenoxy)methyl]-2,3',5'-trifluoro[1,1'-biphenyl]-4-yl]-5-butyl-1,3-dioxane",,1256753-06-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23992/7/4/2/?documentUUID=565bd2b1-61c6-4a41-8d2f-56e1ff9ca23f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC1COC(OC1)C2=CC(=C(C=C2)C3=CC(=C(C(=C3)F)C(OC4=CC(=C(C(=C4)F)F)F)(F)F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/58362062,PubChem,CCCCC1COC(c2ccc(-c3cc(F)c(C(F)(F)Oc4cc(F)c(F)c(F)c4)c(F)c3)c(F)c2)OC1,Train "EU_REACH: 1-methoxy-1-[(2-methylbutan-2-yl)peroxy]cyclohexane",,125768-93-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20436/7/4/2/?documentUUID=bda83525-c124-42d8-951e-0410841be1bc,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C)(C)OOC1(CCCCC1)OC,https://pubchem.ncbi.nlm.nih.gov/compound/14573036,PubChem,CCC(C)(C)OOC1(OC)CCCCC1,Train "EU_REACH: 603-101-3",,125962-78-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27195/7/4/2/?documentUUID=63114169-09d0-417b-802e-bb4aae625213,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)C2=CCC(CC2)C3CCC4(CC3)OCCO4,https://pubchem.ncbi.nlm.nih.gov/compound/91980675,PubChem,Cc1ccc(C2=CCC(C3CCC4(CC3)OCCO4)CC2)cc1,Train "EU_REACH: 2-Isobutyryl-3,N-diphenylacrylamide",,125971-57-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/4803/7/4/2/?documentUUID=43c44a3a-c178-4bff-b477-2dbf0d9487c5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C(=O)C(=CC1=CC=CC=C1)C(=O)NC2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/53394866,PubChem,CC(C)C(=O)C(=Cc1ccccc1)C(=O)Nc1ccccc1,Train "NZ_CCID: 3-Bromo-1-chloro-dimethylhydantoin","NZ_CCID: Hydantoin, 3-bromo-1-chloro-5,5-dimethyl-, 2,4-Imidazolidinedione, 3-bromo-1-chloro-5,5-dimethyl-",126-06-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/50941E84-54E1-443B-9E14-8276396CF98D,"NZ_CCID: Skin Irritation REMARK: Classification based on a protected data source. Eye Irritation REMARK: Classification based on a protected data source.",,NZ_CCID,1,CC1(C(=O)N(C(=O)N1Cl)Br)C,https://pubchem.ncbi.nlm.nih.gov/compound/31335,PubChem,CC1(C)C(=O)N(Br)C(=O)N1Cl,Train "EU_REACH: N-{3-[5-(4-chlorophenyl)-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide",,1262985-23-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32275/7/4/2/?documentUUID=c723d5cf-b0d8-4fae-800a-e52bf23c7403,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CN(C3=C2C=C(C=N3)C4=CC=C(C=C4)Cl)C(=O)C5=C(C=CC=C5Cl)Cl)F,https://pubchem.ncbi.nlm.nih.gov/compound/51001026,PubChem,CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2cn(C(=O)c3c(Cl)cccc3Cl)c3ncc(-c4ccc(Cl)cc4)cc23)c1F,Train "EU_REACH: N-{3-[5-bromo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide",,1262985-24-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31758/7/4/2/?documentUUID=ca052caf-297a-4bb5-b3b6-1e1e62c00944,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CN(C3=C2C=C(C=N3)Br)C(=O)C4=C(C=CC=C4Cl)Cl)F,https://pubchem.ncbi.nlm.nih.gov/compound/51001025,PubChem,CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2cn(C(=O)c3c(Cl)cccc3Cl)c3ncc(Br)cc23)c1F,Train "EU_REACH: 1-(pyrimidin-5-ylmethyl)-3-[3-(trifluoromethyl)phenyl]pyrido[1,2-a]pyrimidin-1-ium-3-ide-2,4-dione",,1263133-33-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24808/7/4/2/?documentUUID=f0315371-8fdf-4726-97eb-341004bc7b1f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC2=[N+](C(=C(C(=O)N2C=C1)C3=CC(=CC=C3)C(F)(F)F)[O-])CC4=CN=CN=C4,https://pubchem.ncbi.nlm.nih.gov/compound/57414497,PubChem,O=c1c(-c2cccc(C(F)(F)F)c2)c([O-])[n+](Cc2cncnc2)c2ccccn12,Train "EU_REACH: bis((1S,2R,6R,7S,8R)-11-(dichloromethylidene)-6-hydroxytricyclo[6.2.1.0²,⁷]undecan-3-one)",,1263184-87-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5907/7/4/2/?documentUUID=7e241ccd-6ac1-45c5-a6d7-731de3526c8f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC2C3C(C1C2=C(Cl)Cl)C(CCC3=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/67808389,PubChem,O=C1CCC(O)C2C3CCC(C3=C(Cl)Cl)C12,Train "EU_REACH: N'-(2-Cyano-5-methoxy-4-nitrophenyl)-N,N-dimethylimidoformamide",,1269400-04-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/34043/7/4/2/?documentUUID=4c0537ee-6ee0-4812-b7c6-4861c2b5e9f8,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C)C=NC1=CC(=C(C=C1C#N)[N+](=O)[O-])OC,https://pubchem.ncbi.nlm.nih.gov/compound/53301992,PubChem,COc1cc(N=CN(C)C)c(C#N)cc1[N+](=O)[O-],Train "NZ_CCID: Pyruvic acid",,127-17-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6CFC8481-1473-4106-B404-4CA959F7F838,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(=O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/1060,PubChem,CC(=O)C(=O)O,Train "JP_CHRIP: N,N-Dimethylacetamide","JP_CHRIP: Acetic acid dimethylamide Dimethylacetamide",127-19-5,NC,JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2012.html,"JP_CHRIP: 【分類根拠】 （１）、（２）より、区分に該当しない。 【根拠データ】 （１）ウサギ（n=2）を用いた皮膚刺激性試験（OECD TG 404相当、閉塞、20時間適用、7日観察）において、全例で24時間後及び72時間後に軽度の紅斑がみられたが、7日以内に回復したとの報告がある（AICIS IMAP (2013)、REACH登録情報 (Accessed Aug. 2021)）。 （２）ウサギ（n=2/群）を用いた皮膚刺激性試験において、最大で500 mg/kgの原液を適用したところ、皮膚刺激性はみられなかったとの報告がある（SIAR (2001)、AICIS IMAP (2013) REACH登録情報 (Accessed Aug. 2021)）。",Provided,JP_CHRIP,1,CN(C)C(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.517H,J-GLOBAL,CC(=O)N(C)C,Train "EU_REACH: diphenyl sulphone",,127-63-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13714/7/4/2/?documentUUID=d8363b87-1ec2-40ec-8a25-998e840933e5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)S(=O)(=O)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/31386,PubChem,O=S(=O)(c1ccccc1)c1ccccc1,Train "NZ_CCID: Lysol",,12772-68-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6F8E833A-3060-4AF5-89F1-1C0970CD36C7,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(CCN)C[C@@H](CO)N,https://pubchem.ncbi.nlm.nih.gov/compound/11607920,PubChem,NCCCC[C@H](N)CO,Train "NZ_CCID: Succinchlorimide US_HSDB: N-Chlorosuccinimide","NZ_CCID: N-chlorosuccinimide",128-09-6,Cat 1,"NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/534B8FD5-DA7C-4C43-9EE6-E07C3A07252B US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/5407","NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"NZ_CCID, US_HSDB",2,C1CC(=O)N(C1=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/31398,PubChem,O=C1CCC(=O)N1Cl,Train "EU_REACH: 2,4,6-triiodo-5-[2-(propan-2-yl)-1,3-dioxane-5-amido]benzene-1,3-dicarbonyl dichloride",,128286-13-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12470/7/4/2/?documentUUID=911b560a-bcd4-4335-9e72-a290fd6848c9,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C1OCC(CO1)C(=O)NC2=C(C(=C(C(=C2I)C(=O)Cl)I)C(=O)Cl)I,https://pubchem.ncbi.nlm.nih.gov/compound/19825447,PubChem,CC(C)C1OCC(C(=O)Nc2c(I)c(C(=O)Cl)c(I)c(C(=O)Cl)c2I)CO1,Train "NZ_CCID: Ethylmaleimide","NZ_CCID: N-Ethylmaleimide",128-53-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/66F99534-0D34-48D4-BDFD-9F372C4C240A,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 41 [Company Data]",,NZ_CCID,1,CCN1C(=O)C=CC1=O,https://pubchem.ncbi.nlm.nih.gov/compound/4362,PubChem,CCN1C(=O)C=CC1=O,Train "EU_REACH: tert-Butyl rel-(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoate",,129332-29-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16845/7/4/2/?documentUUID=21933193-8613-40fa-aebf-c01a4e2d0476,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)N1C2=CC=CC=C2C(=C1/C=C/[C@H](C[C@H](CC(=O)OC(C)(C)C)O)O)C3=CC=C(C=C3)F,https://pubchem.ncbi.nlm.nih.gov/compound/10115940,PubChem,CC(C)n1c(/C=C/[C@@H](O)C[C@@H](O)CC(=O)OC(C)(C)C)c(-c2ccc(F)cc2)c2ccccc21,Train "EU_REACH: (1s,4r)-4-(but-3-en-1-yl)-4'-(4-methylphenyl)-1,1'-bi(cyclohexane)",,129738-42-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30434/7/4/2/?documentUUID=1db48264-a8f7-4804-a695-90416161d657,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)C2CCC(CC2)C3CCC(CC3)CCC=C,https://pubchem.ncbi.nlm.nih.gov/compound/18724321,PubChem,C=CCCC1CCC(C2CCC(c3ccc(C)cc3)CC2)CC1,Train "EU_REACH: 2-[(benzyloxy)(4-ethoxyphenyl)methyl]-4-bromo-1-chlorobenzene",,1298086-15-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11443/7/4/2/?documentUUID=bc8a770f-791c-4f18-b19f-f2810163a6b5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC1=CC=C(C=C1)C(C2=C(C=CC(=C2)Br)Cl)OCC3=CC=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/67153917,PubChem,CCOc1ccc(C(OCc2ccccc2)c2cc(Br)ccc2Cl)cc1,Train "EU_REACH: 4-(hydroxymethyl)-4-methyl-1-phenylpyrazolidin-3-one",,13047-13-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22579/7/4/2/?documentUUID=dfee286f-3d60-4e1b-bd9b-f2481508fea2,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(CN(NC1=O)C2=CC=CC=C2)CO,https://pubchem.ncbi.nlm.nih.gov/compound/92238,PubChem,CC1(CO)CN(c2ccccc2)NC1=O,Train "EU_REACH: 5-[(2-ethylhexanoyl)peroxy]-2,5-dimethylhexan-2-yl 2-ethylhexaneperoxoate",,13052-09-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11958/7/4/2/?documentUUID=f5fab42f-11f4-4370-8c59-87c48600fb98,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)C(=O)OOC(C)(C)CCC(C)(C)OOC(=O)C(CC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/114448,PubChem,CCCCC(CC)C(=O)OOC(C)(C)CCC(C)(C)OOC(=O)C(CC)CCCC,Train "EU_REACH: 5-amino-4-({5-amino-3-cyano-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl}disulfanyl)-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile",,130755-46-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18253/7/4/2/?documentUUID=14ff8475-0c99-4ba2-86ba-0f97d4ffbdad,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(C=C(C(=C1Cl)N2C(=C(C(=N2)C#N)SSC3=C(N(N=C3C#N)C4=C(C=C(C=C4Cl)C(F)(F)F)Cl)N)N)Cl)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/11146906,PubChem,N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(N)c1SSc1c(C#N)nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c1N,Train "EU_REACH: (2Z)-2-phenylhex-2-enenitrile",,130786-09-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30707/7/4/2/?documentUUID=2360e3ed-e8ac-41ab-aaaf-63b3f67bd5b3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC/C=C(\C#N)/C1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/5463415,PubChem,CCC/C=C(\C#N)c1ccccc1,Train "EU_REACH: Methyl 1-(3-chloropyridin-2-yl)-5-hydroxy-3-(hydroxymethyl)-4,5-dihydro-1H-pyrazole-5-carboxylate",,1312304-36-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16308/7/4/2/?documentUUID=5a012298-7c10-46fb-adbe-64c52bf1408d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1(CC(=NN1C2=C(C=CC=N2)Cl)CO)O,https://pubchem.ncbi.nlm.nih.gov/compound/54577408,PubChem,COC(=O)C1(O)CC(CO)=NN1c1ncccc1Cl,Train "EU_REACH: 4-{[(4-benzoylphenoxy)carbonyl]oxy}butyl prop-2-enoate",,131513-00-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12627/7/4/2/?documentUUID=5e65537c-ceb5-4439-800d-d4785a38627e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CC(=O)OCCCCOC(=O)OC1=CC=C(C=C1)C(=O)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/14746151,PubChem,C=CC(=O)OCCCCOC(=O)Oc1ccc(C(=O)c2ccccc2)cc1,Train "NZ_CCID: Chlorotriisopropylsilane","NZ_CCID: triisopropylchlorosilane",13154-24-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/30EB817D-6B8E-4B7B-82A8-47766864A1A9,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)[Si](C(C)C)(C(C)C)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/139400,PubChem,CC(C)[Si](Cl)(C(C)C)C(C)C,Train "EU_REACH: triphenyl[(2E,4E,6E)-3,7,11-trimethyldodeca-2,4,6,10-tetraen-1-yl]-λ⁵-phosphane",,131560-11-7,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30300/7/4/2/?documentUUID=1d845d32-da16-42cb-8e45-41f877da34d9,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=CCCC(=CC=CC(=CC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/73090499,PubChem,CC(C)=CCCC(C)=CC=CC(C)=CC[P+](c1ccccc1)(c1ccccc1)c1ccccc1,Train "EU_REACH: N-vinylformamide",,13162-05-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15886/7/4/2/?documentUUID=bb17fd9c-f5cd-473b-892a-95470e93d4c1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CNC=O,https://pubchem.ncbi.nlm.nih.gov/compound/83191,PubChem,C=CNC=O,Train "JP_CHRIP: 2,4-Dinitro-6-cyclohexylphenol; Dinex","JP_CHRIP: Phenol, 2-cyclohexyl-4,6-dinitro-",131-89-5,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2108e.html,"JP_CHRIP: [Rationale for the Classification] Based on (1) and (2), it was classified in Category 1. The category was changed since new data were obtained. [Evidence Data] (1) This substance had irritative to corrosive effects on the mucous membranes and skin (GESTIS (Access on October 2019)). (2) This substance is a skin irritant (HSDB (Access on October 2019)).",,JP_CHRIP,1,Oc1c(cc(cc1[N+](=O)[O-])[N+](=O)[O-])C1CCCCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.945I,J-GLOBAL,O=[N+]([O-])c1cc(C2CCCCC2)c(O)c([N+](=O)[O-])c1,Train "EU_REACH: dodecyl(2-hydroxy-3-sulphonatopropyl)dimethylammonium",,13197-76-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22843/7/4/2/?documentUUID=2d9f55e3-2288-4fc7-913c-a969d0eb6a54,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCC[N+](C)(C)CC(CS(=O)(=O)[O-])O,https://pubchem.ncbi.nlm.nih.gov/compound/114474,PubChem,CCCCCCCCCCCC[N+](C)(C)CC(O)CS(=O)(=O)[O-],Train "AU_HCIS: Phenol, 4-methyl-2-nonyl-",,13207-27-7,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6708,,,AU_HCIS,1,CCCCCCCCCC1=C(C=CC(=C1)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/83233,PubChem,CCCCCCCCCc1cc(C)ccc1O,Train "EU_REACH: 1,1,1,2,2,3,4,5,5,5-decafluoro-3-methoxy-4-(trifluoromethyl)pentane",,132182-92-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27778/7/4/2/?documentUUID=3af099f4-2dfc-4acf-b646-fe27a33bc682,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(C(C(F)(F)F)(C(F)(F)F)F)(C(C(F)(F)F)(F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/14689855,PubChem,COC(F)(C(F)(F)C(F)(F)F)C(F)(C(F)(F)F)C(F)(F)F,Train "AU_HCIS: Phenol, dinonyl-",,1323-65-5,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6840,,,AU_HCIS,1,CCCCCCCCCC1=C(C(=CC=C1)O)CCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/172321,PubChem,CCCCCCCCCc1cccc(O)c1CCCCCCCCC,Train "EU_REACH: 2-methoxy-4-methylphenyl methyl carbonate",,132638-45-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16996/7/4/2/?documentUUID=ef72fade-5798-4cbb-94b8-11b52259b21a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)OC(=O)OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/15636422,PubChem,COC(=O)Oc1ccc(C)cc1OC,Train "EU_REACH: 2-methylbenzene-1,4-diyl bis{4-[4-(acryloyloxy)butoxy]benzoate}",,132900-75-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1861/7/4/2/?documentUUID=44f459cc-4c69-4464-a0b8-6956d992e903,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=CC(=C1)OC(=O)C2=CC=C(C=C2)OCCCCOC(=O)C=C)OC(=O)C3=CC=C(C=C3)OCCCCOC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/9917022,PubChem,C=CC(=O)OCCCCOc1ccc(C(=O)Oc2ccc(OC(=O)c3ccc(OCCCCOC(=O)C=C)cc3)c(C)c2)cc1,Train "EU_REACH: N-benzylprop-2-enamide",,13304-62-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29488/7/4/2/?documentUUID=9ea5bc25-7c80-47c1-aa69-9602849dea2f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CC(=O)NCC1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/139428,PubChem,C=CC(=O)NCc1ccccc1,Train "EU_REACH: 2-[(2-hydroxyphenyl)methyl]phenol; 2-[(4-hydroxyphenyl)methyl]phenol; 4-[(4-hydroxyphenyl)methyl]phenol",,1333-16-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26309/7/4/2/?documentUUID=794c4abc-1efd-4ddb-8794-a80cc844903d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C(=C1)CC2=CC=CC=C2O)O,https://pubchem.ncbi.nlm.nih.gov/compound/75575,PubChem,Oc1ccccc1Cc1ccccc1O,Train "EU_REACH: 2-{2-[(2R,4R,6R)-4,6-dihydroxyoxan-2-yl]ethyl}-2,3-dihydro-1H-isoindole-1,3-dione",,1333481-90-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23605/7/4/2/?documentUUID=b08b59c2-50f9-4672-a89b-e517168cdbbc,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1[C@H](C[C@@H](O[C@@H]1CCN2C(=O)C3=CC=CC=C3C2=O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/90262225,PubChem,O=C1c2ccccc2C(=O)N1CC[C@@H]1C[C@@H](O)C[C@H](O)O1,Train "EU_REACH: 2-[(1E)-2-(2,4-diamino-6-hydroxypyrimidin-5-yl)diazen-1-yl]-5-methylbenzene-1-sulfonic acid",,1333483-07-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5819/7/4/2/?documentUUID=cb160d38-b650-45c7-ae8e-b04ab65e2aff,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C(=CC=C1)S(=O)(=O)O)N=NC2=C(N=C(NC2=O)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/165364080,PubChem,Cc1cccc(S(=O)(=O)O)c1N=Nc1c(N)nc(N)[nH]c1=O,Train "EU_REACH: Propan-2-yl N-[(S)-(pentafluorophenoxy)(phenoxy)-phosphoryl]-L-alanine",,1334513-02-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18410/7/4/2/?documentUUID=1228c885-efe1-45b0-b456-7b0082625a2a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC1=CC=CC=C1)OC2=C(C(=C(C(=C2F)F)F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/53476763,PubChem,CC(C)OC(=O)[C@H](C)N[P@](=O)(Oc1ccccc1)Oc1c(F)c(F)c(F)c(F)c1F,Train "KR_NCIS: Dimethylsulfamoyl chloride NZ_CCID: Dimethylsulphamoyl chloride","KR_NCIS: Dimethylaminosulfonyl chloride; Dimethylsulfamoyl chloride; N,N-Dimethylaminosulfonyl chloride; N,N-Dimethylsulfamyl chloride; Sulfamoyl chloride, dimethyl-; Sulfamoyl chloride, N,N-dimethyl- NZ_CCID: N,N-Dimethylsulfamoyl chloride, dimethylsulfamoyl chloride",13360-57-1,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/88D9317E-FE3C-4472-9A72-43E3F3DE1CEC","NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"KR_NCIS, NZ_CCID",2,CN(C)S(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/83372,PubChem,CN(C)S(=O)(=O)Cl,Train "EU_REACH: 2-ethylhexyl 2-cyanoacetate",,13361-34-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1727/7/4/2/?documentUUID=f16a9af2-90b6-47ea-98b4-85b6a4c3981d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)CC#N,https://pubchem.ncbi.nlm.nih.gov/compound/96359,PubChem,CCCCC(CC)COC(=O)CC#N,Train "AU_HCIS: 2-Butanone, peroxide KR_NCIS: 2-Butanone, peroxide NZ_CCID: 2-Butanone, peroxide 33-40% in dimethyl phthalate + 1-10% methyl ethyl ketone","KR_NCIS: Ethyl methyl ketone peroxide; Methyl ethyl ketone hydroperoxide; MEKP NZ_CCID: 2-Butanone, peroxide, Butanox LPT, Ethyl methyl ketone peroxide, Ketonox, Mepox, Methyl ethyl ketone hydroperoxide, Methyl ethyl ketone peroxide",1338-23-4,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5494 KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5444433B-0981-4A1D-AE16-7F47D7AC6E5A","NZ_CCID: Skin Irritation SPECIES: RESULT: Corrosive to skin and mucous membrane. REFERENCE SOURCE: Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p. II-108]**PEER REVIEWED** [HSDB] Eye Irritation SPECIES: Rabbit RESULT: Severe (graded 6 on a scale of 0 to 7) REFERENCE SOURCE: [QC Reviewed] Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986. 618. [HSDB]",,"AU_HCIS, KR_NCIS, NZ_CCID",3,CCC(C)(OO)OOC(C)(CC)OO,https://pubchem.ncbi.nlm.nih.gov/compound/3672772,PubChem,CCC(C)(OO)OOC(C)(CC)OO,Train "EU_REACH: 1-{[(2R,3R)-3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole",,133855-98-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33675/7/4/2/?documentUUID=527ed234-8fb4-4233-94ee-b2a9e3e614ed,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C(=C1)C2C(O2)(CN3C=NC=N3)C4=CC=C(C=C4)F)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/3317081,PubChem,Fc1ccc(C2(Cn3cncn3)OC2c2ccccc2Cl)cc1,Train "EU_REACH: 2,2'-diazene-1,2-diylbis(2-methylbutanenitrile)",,13472-08-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5486/7/4/2/?documentUUID=ece7fdf3-fec2-49ad-8eaf-1fdb6d1f3467,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C)(C#N)N=NC(C)(CC)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/93079,PubChem,CCC(C)(C#N)N=NC(C)(C#N)CC,Train "EU_REACH: (4-methylphenyl)(phenyl)methanone",,134-84-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21484/7/4/2/?documentUUID=38e2b668-7b0e-4819-8307-4024f124a40a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)C(=O)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/8652,PubChem,Cc1ccc(C(=O)c2ccccc2)cc1,Train "EU_REACH: 2-[(4-chloro-2-nitrophenyl)diazenyl]-N-(2-methoxyphenyl)-3-oxobutanamide",,13515-40-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11102/7/4/2/?documentUUID=e2553dc2-1a6f-4306-9442-f7629fc6d411,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC=CC=C1OC)N=NC2=C(C=C(C=C2)Cl)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/61637,PubChem,COc1ccccc1NC(=O)C(N=Nc1ccc(Cl)cc1[N+](=O)[O-])C(C)=O,Train "EU_REACH: 2-naphthol JP_CHRIP: beta Naphthol","JP_CHRIP: 2-Hydroxynaphthalene 2-Naphthalenol beta-naphthol Isonaphthol",135-19-3,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26470/7/4/2/?documentUUID=67f1a7e2-d562-4fc8-a780-552cdfa9d077 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-meti-0016e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: It is described that, in a skin irritation test with rabbits (OECD TG 404), after 500 mg of this substance was applied under semi-occlusive conditions for 4 hours, the Draize score was 0 (SIDS (2006)). From the above, this substance was classified as ""Not classified.""",Provided,"EU_REACH, JP_CHRIP",2,Oc1ccc2ccccc2c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.530E,J-GLOBAL,Oc1ccc2ccccc2c1,Train "EU_REACH: 1-(3-chloropyridin-2-yl)-3-{[5-(trifluoromethyl)-2H-1,2,3,4-tetrazol-2-yl]methyl}-1H-pyrazole-5-carboxylic acid",,1352319-02-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19268/7/4/2/?documentUUID=d30d6a9c-20ab-4c5e-aebb-9064afa10598,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(N=C1)N2C(=CC(=N2)CN3N=C(N=N3)C(F)(F)F)C(=O)O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/67289880,PubChem,O=C(O)c1cc(Cn2nnc(C(F)(F)F)n2)nn1-c1ncccc1Cl,Train "EU_REACH: ethyl 4-methyl-2-oxocyclohexane-1-carboxylate",,13537-82-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27448/7/4/2/?documentUUID=813c0797-d8f0-4008-902d-1256490bbae3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1CCC(CC1=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/98162,PubChem,CCOC(=O)C1CCC(C)CC1=O,Train "EU_REACH: 3-hydroxy-N-(3-nitrophenyl)-2-naphthamide",,135-65-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18978/7/4/2/?documentUUID=213f5e70-3e96-4b39-8ebd-9bc66f1d7b42,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C=C(C(=CC2=C1)C(=O)NC3=CC(=CC=C3)[N+](=O)[O-])O,https://pubchem.ncbi.nlm.nih.gov/compound/67277,PubChem,O=C(Nc1cccc([N+](=O)[O-])c1)c1cc2ccccc2cc1O,Train "NZ_CCID: 2-Bromo-4'-phenylacetophenone",,135-73-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F81BA223-02A9-4A66-AF6E-3708D0692A20,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/67282,PubChem,O=C(CBr)c1ccc(-c2ccccc2)cc1,Train "EU_REACH: (1R)-1-[(4R,4aR,8aS)-2,6-bis(3,4-dimethylphenyl)tetrahydro[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol",,135861-56-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8016/7/4/2/?documentUUID=aad19ea0-46d5-4012-a320-703f2f851f28,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)C2OC[C@H]3[C@@H](O2)[C@H](OC(O3)C4=CC(=C(C=C4)C)C)[C@@H](CO)O)C,https://pubchem.ncbi.nlm.nih.gov/compound/18666587,PubChem,Cc1ccc(C2OC[C@@H]3OC(c4ccc(C)c(C)c4)O[C@H]([C@H](O)CO)[C@@H]3O2)cc1C,Train "KR_NCIS: 1,4-Dithiane-2,5-di(methanethiol)",,136122-15-1,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C1C(SCC(S1)CS)CS,https://pubchem.ncbi.nlm.nih.gov/compound/11401600,PubChem,SCC1CSC(CS)CS1,Train "KR_NCIS: 2-Isocyanatoethyl 2-propenoate",,13641-96-8,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C=CC(=O)OCCN=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/3014768,PubChem,C=CC(=O)OCCN=C=O,Train "EU_REACH: 2,6-dimethylphenyl 4-hydroxybenzene-1-sulfonate",,1364731-90-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6296/7/4/2/?documentUUID=0e0cc07b-3d6b-460f-ba72-c4fa60d156c7,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C(=CC=C1)C)OS(=O)(=O)C2=CC=C(C=C2)O,https://pubchem.ncbi.nlm.nih.gov/compound/89798625,PubChem,Cc1cccc(C)c1OS(=O)(=O)c1ccc(O)cc1,Train "JP_CHRIP: Tris(dichloropropyl) phosphate","JP_CHRIP: Tris(1,3-dichloro-2-propyl) phosphate tris(1,3-dichloro-2-propyl)phosphate",13674-87-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0089e.html,"JP_CHRIP: In the rabbit test (OECD TG404, GLP-compliant) that 0.5 ml of test substance was instilled to 3 rabbits for 4 hours with semi-occlusive conditions, erythema (grade 2) was recorded in 2/3 animals after one hour and persisted for 24 hours in one animal. Erythema (grade 1) was noted in the third animal. There was no edema. All reactions disappeared within 48 hours (EU-RAR (2008)). Based on the document, the substance was classified as ""Not classified"".",Provided,JP_CHRIP,1,ClCC(CCl)OP(=O)(OC(CCl)CCl)OC(CCl)CCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J640H,J-GLOBAL,O=P(OC(CCl)CCl)(OC(CCl)CCl)OC(CCl)CCl,Train "EU_REACH: 1,8-bis(phenylsulfanyl)-9,10-dihydroanthracene-9,10-dione",,13676-91-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11269/7/4/2/?documentUUID=62f73577-a8ad-4bd2-bb4e-dee22c6bd943,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)SC2=CC=CC3=C2C(=O)C4=C(C3=O)C=CC=C4SC5=CC=CC=C5,https://pubchem.ncbi.nlm.nih.gov/compound/83650,PubChem,O=C1c2cccc(Sc3ccccc3)c2C(=O)c2c(Sc3ccccc3)cccc21,Train "EU_REACH: 4,4'-methylenebis(2,6-diethylaniline)",,13680-35-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21592/7/4/2/?documentUUID=e8334bc4-98cb-44bd-a2f7-0daf0ab3b068,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1=CC(=CC(=C1N)CC)CC2=CC(=C(C(=C2)CC)N)CC,https://pubchem.ncbi.nlm.nih.gov/compound/83656,PubChem,CCc1cc(Cc2cc(CC)c(N)c(CC)c2)cc(CC)c1N,Train "KR_NCIS: Nonylphenols","KR_NCIS: 2-Nonylphenol; o-Nonylphenol; Phenol, 2-nonyl-; Phenol, o-nonyl-",136-83-4,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCCCCCCCCC1=CC=CC=C1O,https://pubchem.ncbi.nlm.nih.gov/compound/67296,PubChem,CCCCCCCCCc1ccccc1O,Train "EU_REACH: 2-[(2-{bis[(dioctadecylcarbamoyl)methyl]amino}ethyl)[(dioctadecylcarbamoyl)methyl]amino]-N,N-dioctadecylacetamide",,136920-07-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18106/7/4/2/?documentUUID=538f48e7-efc5-4301-afc3-966b41998e4f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/6083,PubChem,Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]1O,Train "EU_REACH: (5Z)-5-(2-methylpropylidene)imidazolidine-2,4-dione",,1369499-44-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20950/7/4/2/?documentUUID=904877a4-d525-4ba7-9aa1-d5f5e052771a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)/C=C\1/C(=O)NC(=O)N1,https://pubchem.ncbi.nlm.nih.gov/compound/13392838,PubChem,CC(C)/C=C1\NC(=O)NC1=O,Train "EU_REACH: 4,5-dihydro-2-undecyl-1H-imidazole-1-ethanol",,136-99-2,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26475/7/4/2/?documentUUID=74178948-b943-4a9b-9ba6-ecae27251ab3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCC1=NCCN1CCO,https://pubchem.ncbi.nlm.nih.gov/compound/8709,PubChem,CCCCCCCCCCCC1=NCCN1CCO,Train "EU_REACH: 4-(2-{2-amino-4-oxo-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)benzoic acid",,137281-39-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/3392/7/4/2/?documentUUID=9c93dd05-0446-4aeb-993c-a8dcfbfd298b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/135405776,PubChem,Nc1nc2[nH]cc(CCc3ccc(C(=O)O)cc3)c2c(=O)[nH]1,Train "EU_REACH: tert-Butyl 4-({6-[7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}pyridin-3-yl)piperazine-1-carboxylate",,1374639-78-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27666/7/4/2/?documentUUID=7406d2ef-a58e-4510-ba25-56b8c67dd94c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)OC(=O)N1CCN(CC1)C2=CN=C(C=C2)NC3=NC=C4C=C(N(C4=N3)C5CCCC5)C(=O)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/67354206,PubChem,CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(C(=O)OC(C)(C)C)CC4)cn3)nc2n1C1CCCC1,Train "EU_REACH: N-isopropylmethacrylamide",,13749-61-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5438/7/4/2/?documentUUID=feb7e492-09bc-4da4-9e48-d35e43d2b7d8,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)NC(=O)C(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/83698,PubChem,C=C(C)C(=O)NC(C)C,Train "EU_REACH: 2-[4,6-bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl]-5-{3-[(2-ethylhexyl)oxy]-2-hydroxypropoxy}phenol",,137658-79-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29511/7/4/2/?documentUUID=14a73c26-f93e-4e0d-8ddb-751101590bc6,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COCC(COC1=CC(=C(C=C1)C2=NC(=NC(=N2)C3=C(C=C(C=C3)C)C)C4=C(C=C(C=C4)C)C)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/135530657,PubChem,CCCCC(CC)COCC(O)COc1ccc(-c2nc(-c3ccc(C)cc3C)nc(-c3ccc(C)cc3C)n2)c(O)c1,Train "NZ_CCID: Piperidine, 4-[3-(dichloromethylsilyl)propoxy]-2,2,6,6-tetramethyl-, hydrolyzed, polymd.",,137898-96-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6CDA1135-45B4-4EA8-B148-F9D2664446AD,,,NZ_CCID,1,CC1(CC(CC(N1)(C)C)OCCC[Si]C(Cl)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/53424536,PubChem,CC1(C)CC(OCCC[Si]C(Cl)Cl)CC(C)(C)N1,Train "AU_HCIS: Phenol, 2,4-dinonyl-",,137-99-5,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5790,,,AU_HCIS,1,CCCCCCCCCC1=CC(=C(C=C1)O)CCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/8735,PubChem,CCCCCCCCCc1ccc(O)c(CCCCCCCCC)c1,Train "EU_REACH: 1-difluoromethanesulfonyl-3-(4,6-dimethoxy-1,3,5-triazin-2-yl)-7-fluoro-1H-indol-2-ol",,1383692-20-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18053/7/4/2/?documentUUID=d31db7aa-e1b8-4361-bfbe-1be8b1745ba3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=NC(=NC(=N1)C2=C(N(C3=C2C=CC=C3F)S(=O)(=O)C(F)F)O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/136338231,PubChem,COc1nc(OC)nc(-c2c(O)n(S(=O)(=O)C(F)F)c3c(F)cccc23)n1,Train "EU_REACH: 3-(4,6-dimethoxy-1,3,5-triazin-2-yl)-7-fluoro-2,3-dihydro-1H-indol-2-one",,1383706-71-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18051/7/4/2/?documentUUID=1a8dc607-8ac9-4dae-8681-316b8d976cb3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=NC(=NC(=N1)C2C3=C(C(=CC=C3)F)NC2=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/67982437,PubChem,COc1nc(OC)nc(C2C(=O)Nc3c(F)cccc32)n1,Train "EU_REACH: (3R,4R)-1,1,1,2,2,3,4,5,5,5-decafluoropentane; (3S,4S)-1,1,1,2,2,3,4,5,5,5-decafluoropentane",,138495-42-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5463/7/4/2/?documentUUID=f59b478a-81f6-45e4-8652-ea5caf04dbef,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(C(C(F)(F)F)F)(C(C(F)(F)F)(F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/86240,PubChem,FC(C(F)C(F)(F)C(F)(F)F)C(F)(F)F,Train "EU_REACH: 5-methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile",,138564-59-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32798/7/4/2/?documentUUID=8566bea1-5a59-4092-8e20-97bca0223339,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(S1)NC2=CC=CC=C2[N+](=O)[O-])C#N,https://pubchem.ncbi.nlm.nih.gov/compound/395460,PubChem,Cc1cc(C#N)c(Nc2ccccc2[N+](=O)[O-])s1,Train "EU_REACH: (1R,2R)-1,3-Dihydroxy-1-(4-nitrophenyl)propyl-2-ammonium (1R, 5S)-5-(dimethylphenylsilyl)-2-(hydroxymethyl)cyclopent-2-ene-1-carboxylate",,1388152-30-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5606/7/4/2/?documentUUID=fcb75064-659a-46be-9332-15536ebf75d1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](C)([C@H]1CC=C([C@@H]1C(=O)O[C@](C2=CC=C(C=C2)[N+](=O)[O-])([C@@H](CO)N)O)CO)C3=CC=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/165362778,PubChem,C[Si](C)(c1ccccc1)[C@H]1CC=C(CO)[C@@H]1C(=O)O[C@](O)(c1ccc([N+](=O)[O-])cc1)[C@H](N)CO,Train "EU_REACH: 2-{2-[2-(carboxymethoxy)ethoxy]ethoxy}acetic acid",,13887-98-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25085/7/4/2/?documentUUID=7fba0b6f-f04c-419f-8085-a493357cc89d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(COCC(=O)O)OCCOCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/83793,PubChem,O=C(O)COCCOCCOCC(=O)O,Train "EU_REACH: 3-{[bis(2,6-dimethylphenoxy)phosphoryl]oxy}phenyl bis(2,6-dimethylphenyl) phosphate",,139189-30-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33982/7/4/2/?documentUUID=acbd5ce7-2247-4889-9f5d-01969aac1969,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C(=CC=C1)C)OP(=O)(OC2=CC(=CC=C2)OP(=O)(OC3=C(C=CC=C3C)C)OC4=C(C=CC=C4C)C)OC5=C(C=CC=C5C)C,https://pubchem.ncbi.nlm.nih.gov/compound/9874767,PubChem,Cc1cccc(C)c1OP(=O)(Oc1cccc(OP(=O)(Oc2c(C)cccc2C)Oc2c(C)cccc2C)c1)Oc1c(C)cccc1C,Train "EU_REACH: methyl 2-[[4-(2-cyanophenyl)phenyl]methylamino]-3-nitrobenzoate",,139481-28-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18174/7/4/2/?documentUUID=361b625d-6119-4a0f-8115-c211a1de1dda,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1=C(C(=CC=C1)[N+](=O)[O-])NCC2=CC=C(C=C2)C3=CC=CC=C3C#N,https://pubchem.ncbi.nlm.nih.gov/compound/15654651,PubChem,COC(=O)c1cccc([N+](=O)[O-])c1NCc1ccc(-c2ccccc2C#N)cc1,Train "EU_REACH: Methyl 1-[(2’-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate",,139481-44-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18072/7/4/2/?documentUUID=70708469-5d76-4529-8f5d-2d6e1902f1b2,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C#N)C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/15654674,PubChem,CCOc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2C#N)cc1,Train "EU_REACH: 2-ethoxy-1-{[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-1,3-benzodiazole-7-carboxylic acid",,139481-59-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11979/7/4/2/?documentUUID=f5b01d28-a55d-43a1-ac7e-2416f721b76b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/2541,PubChem,CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1,Train "EU_REACH: methyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate",,139481-69-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18135/7/4/2/?documentUUID=5180bb1c-f0ea-41e5-b8fe-8e7d9d0c5e04,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/15654696,PubChem,CCOc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1,Train "JP_CHRIP: sec-Butylamine KR_NCIS: 1-Methylpropylamine NZ_CCID: s-Butylamine","JP_CHRIP: 1-Methyl propylamine 1-methylpropylamine 2-Aminobutane 2-Butanamine KR_NCIS: (+)-(S)-sec-Butylamine; (+)-2-Aminobutane; (+)-2-Butylamine; (+)-sec-Butylamine; (+/-)-2-Butanamine; 1-Methylpropylamine; 2-Aminobutane; 2-Butanamine; 2-Butanamine, (2S)-; sec-Butylamine NZ_CCID: (RS)-sec-Butylamine, 1-Methylpropanamine, 1-Methylpropylamine, 2-AB, 2-Aminobutane, 2-Butanamine, 2-Butylamine, Butafume, Sec-butylamine, Tutane",13952-84-6,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0062e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0A694DC6-5774-458B-B162-946F4B872A60","JP_CHRIP: In the rabbit test, the substance was reported as a primary irritant (JMPR 320 (1975)), and the substance was classified as ""C; R35"" (EC-JRC (ESIS) (Access on Jul. 2010)). Based on these documents, the substance was classified as Category 1. As relevant notes, contact with human skin causes irritation or burns or dermatitis (HSDB (2008)). NZ_CCID: Skin Irritation UN CLASS: PG II Eye Irritation R PHRASE: R 35 [Company Data]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,CCC(C)N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J8.464F,J-GLOBAL,CCC(C)N,Train "KR_NCIS: Nonylphenols","KR_NCIS: 3-Nonylphenol; m-Nonylphenol; Phenol, 3-nonyl-; Phenol, m-nonyl-",139-84-4,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCCCCCCCCC1=CC(=CC=C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/67320,PubChem,CCCCCCCCCc1cccc(O)c1,Train "EU_REACH: tert-butyl 5'-acetyl-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-carboxylate",,1398609-81-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32316/7/4/2/?documentUUID=9faf662a-d72a-4160-8919-adf0e30a2741,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C1=CC2=C(C=C1)C3(CN(C3)C(=O)OC(C)(C)C)OC2,https://pubchem.ncbi.nlm.nih.gov/compound/70663143,PubChem,CC(=O)c1ccc2c(c1)COC21CN(C(=O)OC(C)(C)C)C1,Train "JP_CHRIP: 2-piperazin-1-ylethylamine NZ_CCID: 2-(1-Piperazinyl) ethylamine","JP_CHRIP: 1-Aminoethylpiperazine 1-Piperazineethanamine NZ_CCID: N-aminoethylpiperazine",140-31-8,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0194e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B7AD9C90-E8E2-428C-A8FD-E8EAB5FCC3FA","JP_CHRIP: In Draize tests using rabbits, the substance was reported to be corrosive and caused skin necrosis as a result of a 24-hour exposure (IUCLID, 2000). Furthermore, it is rated as R34 in the EU classification (EU-Annex 1, accessed in November 2008). Based on this information, the substance was classified into Category 1. According to HSDB (2002), it has human health effects such as strong irritations to the skin, eyes, and respiratory system. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,NCCN1CCNCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J35.446E,J-GLOBAL,NCCN1CCNCC1,Train "EU_REACH: 2-methylpentanedioic acid, dimethyl ester",,14035-94-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32878/7/4/2/?documentUUID=2a99981a-01e6-4203-93b2-4d1989a8a0fd,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CCC(=O)OC)C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/118086,PubChem,COC(=O)CCC(C)C(=O)OC,Train "EU_REACH: 6,6'-di-tert-butyl-4,4'-dimethoxy-[1,1'-biphenyl]-2,2'-diol",,14078-41-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11829/7/4/2/?documentUUID=aaf46a58-26b5-45cb-8113-d62ad2b4bbfb,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1=CC(=CC(=C1O)C2=C(C(=CC(=C2)OC)C(C)(C)C)O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/119234,PubChem,COc1cc(-c2cc(OC)cc(C(C)(C)C)c2O)c(O)c(C(C)(C)C)c1,Train "EU_REACH: 2-[3-(heptan-3-yl)-1,2-oxazolidin-2-yl]ethyl N-{6-[({2-[3-(heptan-3-yl)-1,2-oxazolidin-2-yl]ethoxy}carbonyl)amino]hexyl}carbamate",,140921-24-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11360/7/4/2/?documentUUID=f7bc5de0-4d9d-45a1-8f88-4039dd309fbb,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)C1N(CCO1)CCOC(=O)NCCCCCCNC(=O)OCCN2CCOC2C(CC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/14993651,PubChem,CCCCC(CC)C1OCCN1CCOC(=O)NCCCCCCNC(=O)OCCN1CCOC1C(CC)CCCC,Train "JP_CHRIP: 2-Aminoethanol NZ_CCID: Ethanolamine US_HSDB: 2-AMINOETHANOL","JP_CHRIP: 2-aminoethanol 2-Hydroxyethylamine Ethanol, 2-amino- NZ_CCID: 1-Amino-2-hydroxyethane, 2-Amino-1-ethanol, 2-Aminoethanol, 2-Hydroxyethanamine, 2-Hydroxyethylamine, Aminoethanol, Colamine, Ethanol, 2-amino-, Ethylolamine, Glycinol, MEA, Monoethanolamine, Olamine",141-43-5,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2007e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EDA0F5DC-8E8F-4749-88D3-50FA800F82DA US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/531","JP_CHRIP: In a test in which the undiluted solution was applied to the skin of rabbits for 1 minute or 5 minutes and washed, bleeding and application time-dependent redness and necrosis were observed in the skin 1 day after application, and from 8 days after application, formation of desquamation was observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). In addition, necrosis was observed at the site of application in the other two tests where the undiluted solution was applied to the skin of rabbits and in 1 study by application to the auricles of rabbits (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). Moreover, there is a report that redness and edema were observed in a 1.5-hour semi-occlusive dermal application test in human volunteers (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). From the above results, it was classified in Category 1A. Besides, this substance was classified as ""C; R34"" in the EU DSD classification, and as ""H314 Skin corr. 1B"" in the EU CLP classification. NZ_CCID: Skin Irritation SPECIES: Rat, mouse, rabbit and dog RESULT: Liquid MEA is corrosive to the skin and eyes at high concentrations, and that at lower concentrations MEA is a skin and eye irritant. REFERENCE SOURCE: [Toxicology Unit, Health and Safety Executive, Bootle, UK] REMARK: C ? 25 % C; R20/21/22-34 10 % ? C < 25 % C; R34 5 % ? C < 10 % Xi; R36/37/38 [ECB - Working db] Eye Irritation SPECIES: Rat, mouse, rabbit and dog RESULT: Liquid MEA is corrosive to the skin and eyes at high concentrations, and that at lower concentrations MEA is a skin and eye irritant. REFERENCE SOURCE: [Toxicology Unit, Health and Safety Executive, Bootle, UK] REMARK: C ? 25 % C; R20/21/22-34 10 % ? C < 25 % C; R34 5 % ? C < 10 % Xi; R36/37/38 [ECB - Working db]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,NCCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.536D,J-GLOBAL,NCCO,Train "EU_REACH: 2,2,4,4,6,6,8,8-octamethyl-3,5,7-trioxa-2,4,6,8-tetrasilanonane",,141-62-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5665/7/4/2/?documentUUID=59495e3f-4b05-44ba-b8be-05b4d9067540,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/8852,PubChem,C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C,Train "EU_REACH: 4-(2-butyl-5-nitro-1-benzofuran-3-carbonyl)phenol",,141645-16-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6085/7/4/2/?documentUUID=85bef5f1-c38c-41b8-8d16-176f08e55289,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC1=C(C2=C(O1)C=CC(=C2)[N+](=O)[O-])C(=O)C3=CC=C(C=C3)O,https://pubchem.ncbi.nlm.nih.gov/compound/11473234,PubChem,CCCCc1oc2ccc([N+](=O)[O-])cc2c1C(=O)c1ccc(O)cc1,Train "EU_REACH: (3E)-2-chloro-3-(hydroxymethylidene)cyclohex-1-ene-1-carbaldehyde",,1416808-92-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11440/7/4/2/?documentUUID=3047dce7-586b-4c30-8ddd-12690267cc91,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C/C(=C\O)/C(=C(C1)C=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/10986754,PubChem,O=CC1=C(Cl)/C(=C/O)CCC1,Train "JP_CHRIP: Butyryl chloride NZ_CCID: Butyryl chloride US_HSDB: n-Butyryl chloride",,141-75-3,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0024e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A7341F9C-DD1D-42B9-A6CC-84C89212299D US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/6016","JP_CHRIP: Because there is the information that it is a strong irritant to tissue (HSDB (2003)) and it is classified in C; R34 in EU classification (EC-JRC (ESIS) (Access on Jan. 2011)), it was classified in Category 1. Besides, this substance is classified in class 3, subsidiary risk 8PGII in UNRTDG (UN2353). NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,CCCC(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.538K,J-GLOBAL,CCCC(=O)Cl,Train "JP_CHRIP: Ethyl acetoacetate","JP_CHRIP: 1-Ethoxybutane-1,3-dione 3-Oxobutanoic acid ethyl ester Acetoacetic acid ethyl ester Ethyl acetylacetate",141-97-9,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0061e.html,"JP_CHRIP: The substance was classified as ""Not classified"" based on the documented case of ""not irritating"" resulted from rabbit test (OECD TG 404, GLP-compliant) in which 0.5 mL of test substance was applied for 4 hours (EU-RAR 13 (2002), IUCLID (2000)).",Provided,JP_CHRIP,1,CCOC(=O)CC(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.493H,J-GLOBAL,CCOC(=O)CC(C)=O,Train "EU_REACH: bis(2-ethylhexyl) but-2-enedioate JP_CHRIP: Bis(2-ethylhexan-1-yl) maleate",,142-16-5,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14675/7/4/2/?documentUUID=460fe4dd-a371-4e35-975e-2a9abfca8c16 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0003e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" (Category 3 in UN GHS classification) from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 13-day observation), erythema and edema completely disappeared within 10 days, and slight irritation was seen (erythema/eschar score: 2/2/2, edema score: 1.3/1.3/1.3) (REACH registration dossier (Accessed May 2020)).",Provided,"EU_REACH, JP_CHRIP",2,CCCCC(CC)COC(=O)/C=C\C(=O)OCC(CC)CCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J36.805I,J-GLOBAL,CCCCC(CC)COC(=O)/C=C\C(=O)OCC(CC)CCCC,Train "NZ_CCID: Hexanoyl chloride","NZ_CCID: caproyl chloride",142-61-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/71C35BD9-02E5-4A04-942F-5C0F5F86D3D7,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/67340,PubChem,CCCCCC(=O)Cl,Train "JP_CHRIP: Hexanoic acid NZ_CCID: Hexanoic acid","JP_CHRIP: Butylacetic acid Capronic acid n-Caproic acid",142-62-1,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0075e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A8127B28-67CC-4A2F-AEC0-CA827FDB3D19","JP_CHRIP: Based on results that necrosis was followed by scar formation with the scars persisting for 21 days after application in a rabbit test (OECD TG404 (GLP)) (BUA 241 (2002)), the substance was classified into Category 1. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",Provided,"JP_CHRIP, NZ_CCID",2,CCCCCC(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.546A,J-GLOBAL,CCCCCC(=O)O,Train "JP_CHRIP: 2,4-Hexadienal",,142-83-6,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0003e.html,"JP_CHRIP: In a test in which 0.5 mL of the undiluted test substance was applied to the rabbit skin for 4 hours, 4 out of 4 animals showed severe edema immediately after application and severe erythema 2-3 days after application, and the skin hardened and was stained brown. Furthermore, the treated skin was pitted on day 7 in two animals, and the primary skin irritation index was 7.08 (ECETOC TR66 (1995)). Therefore, it was classified in Category 1.",,JP_CHRIP,1,C/C=C/C=C/C=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J12.975E,J-GLOBAL,C/C=C/C=C/C=O,Train "AU_HCIS: dipropylamine JP_CHRIP: Di-n-propylamine NZ_CCID: 1-Propanamine, N-propyl-","AU_HCIS: 1-Propanamine, N-propyl- NZ_CCID: Dipropylamine, N-Propyl-1-propanamine, n-Dipropylamine",142-84-7,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1601 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-mhlw-2020e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B7616E4F-5F19-4536-B1BB-ECC1766C265A","JP_CHRIP: [Rationale for the Classification] Based on (1) and (2), it was classified in Category 1A. Besides, the category was changed from the previous classification by using new information sources. [Evidence Data] (1) In a GLP-compliant study in which rabbits were divided into 4 groups (n=3) and exposed to 0.5 mL of this substance by patch for one minute, necrosis with erythema was observed in one or more animals 1 hour after application in the group in which the skin was wiped with dry gauze, in the group in which the skin was washed with distilled water, and in the group in which the skin was swabbed with PEG 300 after washing with distilled water (NICNAS IMAP (Accessed Jul. 2018), REACH registration dossier (Accessed Sept. 2018), HSDB (2014)). (2) There is a report that in a Draize test with rabbits (n=3), erythema and edema were observed after a 3-minute application, and this did not resolve after 7 days (REACH registration dossier (Accessed Sept. 2018)). [Reference Data, etc.] (3) In a Draize test or a test similar to OECD TG404 with rabbits, aliphatic secondary amines are known to be corrosive to the skin (SIAP (2013)) NZ_CCID: Skin Irritation SPECIES: Rabbit RESULT: Highly corrosive REFERENCE SOURCE: BASF AG Ludwigshafen (42) BASF Aktiengesellschaft, unveroeffentlichte Untersuchung (XIX/320) 30.12.1969. [IUCLID 2000] REMARK: EC Classification: Highly corrosive (causes severe burns). Eye Irritation SPECIES: Rabbit RESULT: Irritating REFERENCE SOURCE: BASF AG Ludwigshafen (42) BASF Aktiengesellschaft, unveroeffentlichte Untersuchung (XIX/320) 30.12.1967 [IUCLID 2000] REMARK: EC Classification: Risk of serious damage to eyes.",Provided,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CCCNCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.547J,J-GLOBAL,CCCNCCC,Train "ChemSkin: Isopropyl palmitate EU_REACH: propan-2-yl hexadecanoate",,142-91-6,NC,"ChemSkin: https://doi.org/10.3390/toxics9110314 EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15814/7/4/2/?documentUUID=e11fe757-ca7c-4ce1-995f-656f3e4617c9","ChemSkin: Experimental study (OECD TG 404) EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,"ChemSkin, EU_REACH",2,CCCCCCCCCCCCCCCC(=O)OC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/8907,PubChem,CCCCCCCCCCCCCCCC(=O)OC(C)C,Train "ChemSkin: Dodecanoic acid (lauric acid) EU_REACH: dodecanoic acid",,143-07-7,NC,"ChemSkin: https://doi.org/10.3390/toxics9110314 EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15262/7/4/2/?documentUUID=cf62d791-1fcf-4912-b7fd-48b66285b3f7","ChemSkin: Experimental study (OECD TG 404) EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,"ChemSkin, EU_REACH",2,CCCCCCCCCCCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/3893,PubChem,CCCCCCCCCCCC(=O)O,Train "NZ_CCID: Dihexylamine",,143-16-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F061F262-F8F5-4FFF-B9E4-67DA21994277,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCCNCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/8920,PubChem,CCCCCCNCCCCCC,Train "EU_REACH: 2,5,8,11,14-pentaoxapentadecane",,143-24-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14547/7/4/2/?documentUUID=e24f12fb-e08a-49c4-afd6-cf00024f2ef3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COCCOCCOCCOCCOC,https://pubchem.ncbi.nlm.nih.gov/compound/8925,PubChem,COCCOCCOCCOCCOC,Train "EU_REACH: methyl 2-[(4-hydroxybenzenesulfonyl)oxy]benzoate",,1432505-97-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6300/7/4/2/?documentUUID=dbb0fb72-12c8-457a-b94e-2812666d993d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1=CC=CC=C1OS(=O)(=O)C2=CC=C(C=C2)O,https://pubchem.ncbi.nlm.nih.gov/compound/102494927,PubChem,COC(=O)c1ccccc1OS(=O)(=O)c1ccc(O)cc1,Train "AU_HCIS: 1-Hexadecanamine NZ_CCID: Hexadecylamine","NZ_CCID: 1-hexadecylamine",143-27-1,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4990 NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F98A6C94-D15B-4261-8AF7-572D7B39149F","NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"AU_HCIS, NZ_CCID",2,CCCCCCCCCCCCCCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/8926,PubChem,CCCCCCCCCCCCCCCCN,Train "EU_REACH: 5,8,11,13,16,19-hexaoxatricosane",,143-29-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13599/7/4/2/?documentUUID=d149c6fd-4741-47c8-805d-16523793dd69,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOCCOCCOCOCCOCCOCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/8928,PubChem,CCCCOCCOCCOCOCCOCCOCCCC,Train "EU_REACH: 4-methyl-2-[(2-nitrophenyl)diazenyl]phenol",,1435-71-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1573/7/4/2/?documentUUID=3c6e1daa-ab5e-4130-83c5-2edb261414b5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)O)N=NC2=CC=CC=C2[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/74029,PubChem,Cc1ccc(O)c(N=Nc2ccccc2[N+](=O)[O-])c1,Train "EU_REACH: 9-bromo-3-(2-bromoacetyl)-8,9,10,11-tetrahydro-5H-6-oxatetraphen-8-one",,1438383-89-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16398/7/4/2/?documentUUID=51b6a241-0cc9-44dc-ac48-6f1ecc816ad0,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC2=CC3=C(C=C2C(=O)C1Br)OCC4=C3C=CC(=C4)C(=O)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/86688372,PubChem,O=C(CBr)c1ccc2c(c1)COc1cc3c(cc1-2)CCC(Br)C3=O,Train "KR_NCIS: 3-Ethyl-2-methyl-2-(3-methylbutyl)-1,3-oxazolidine",,143860-04-2,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCN1CCOC1(C)CCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/4199499,PubChem,CCN1CCOC1(C)CCC(C)C,Train "EU_REACH: Glycerol, ethoxylated, esters with acrylic acid",,144086-03-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12378/7/4/2/?documentUUID=10e37b6e-9eca-4d54-8972-94b622101eb8,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(C(CO)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/753,PubChem,OCC(O)CO,Train "EU_REACH: 1,2,3-tris(2-ethylhexyl) 2-(acetyloxy)propane-1,2,3-tricarboxylate",,144-15-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6763/7/4/2/?documentUUID=1375e3b7-4c1d-4864-9ecc-226d90e5b336,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)CC(CC(=O)OCC(CC)CCCC)(C(=O)OCC(CC)CCCC)OC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/101632,PubChem,CCCCC(CC)COC(=O)CC(CC(=O)OCC(CC)CCCC)(OC(C)=O)C(=O)OCC(CC)CCCC,Train "EU_REACH: 3-(3,5-di-tert-butyl-4-hydroxyphenyl)-N-octadecylpropanamide",,14442-94-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7426/7/4/2/?documentUUID=60d922fb-2010-4b61-8593-a1b3ad0c3146,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCCCNC(=O)CCC1=CC(=C(C(=C1)C(C)(C)C)O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/19736307,PubChem,CCCCCCCCCCCCCCCCCCNC(=O)CCc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1,Train "EU_REACH: Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, 2-ethylhexyl ester",,144429-84-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/28295/7/4/2/?documentUUID=a663392f-8ad3-48f2-a825-5d2e0506083e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)CCC1=CC(=C(C(=C1)C(C)(C)C)O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/11486113,PubChem,CCCCC(CC)COC(=O)CCc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1,Train "JP_CHRIP: Fluoroacetic acid US_HSDB: Fluoroacetic acid","JP_CHRIP: alpha-Fluoroacetic acid FAA Monofluoroacetic acid",144-49-0,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2090e.html US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/2082","JP_CHRIP: [Rationale for the Classification] Based on (1) and (2), it was classified in Category 1. [Evidence Data] (1) Following contact with the skin, burning sensation, reddening, severe irritation, and painful tissue damage may occur. The extent of these symptoms is assumed to be dependent on the concentration and duration of exposure (GESTIS (Access on September 2019)). (2) This substance is irritating (HSDB (Access on September 2019)).",,"JP_CHRIP, US_HSDB",2,OC(=O)CF,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.550J,J-GLOBAL,O=C(O)CF,Train "JP_CHRIP: N-methyldithiocarbamic acid","JP_CHRIP: N-Methyldithiocarbamic acid N-methyldithiocarbamic acid (synonym:carbam)",144-54-7,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0499e.html,"JP_CHRIP: Based on the evidence of destruction of skin tissues observed in rabbit skin irritation tests (24 hour application) (Agricultural Chemical Registration Data (1987)).",,JP_CHRIP,1,CNC(=S)S,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J9.912K,J-GLOBAL,CNC(=S)S,Train "NZ_CCID: Dehydroabietylamine (mixture of isomeres)","NZ_CCID: dehydroabietylamine",1446-61-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/108391B1-B714-451B-B37F-CD62BD977A9D,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)C1=CC2=C(C=C1)[C@]3(CCC[C@@]([C@@H]3CC2)(C)CN)C,https://pubchem.ncbi.nlm.nih.gov/compound/62034,PubChem,CC(C)c1ccc2c(c1)CC[C@H]1[C@](C)(CN)CCC[C@]21C,Train "EU_REACH: 4'-{[4-methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]methyl}-[1,1'-biphenyl]-2-carbonitrile",,144702-27-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7768/7/4/2/?documentUUID=4d85316f-51d5-4c76-bc7b-2b1e77c2b6ec,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1=NC2=C(N1CC3=CC=C(C=C3)C4=CC=CC=C4C#N)C=C(C=C2C)C5=NC6=CC=CC=C6N5C,https://pubchem.ncbi.nlm.nih.gov/compound/11961510,PubChem,CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C#N)cc1,Train "EU_REACH: (4E)-5-cyclohexyl-2,4-dimethylpent-4-enal",,1449104-34-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29595/7/4/2/?documentUUID=3a7d568c-6692-418e-af21-2e700a929fac,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C/C(=C/C1CCCCC1)/C)C=O,https://pubchem.ncbi.nlm.nih.gov/compound/89738936,PubChem,C/C(=C\C1CCCCC1)CC(C)C=O,Train "EU_REACH: 3-[dimethoxy(methyl)silyl]propyl methacrylate",,14513-34-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24122/7/4/2/?documentUUID=e16a510c-a069-43e6-b411-6dec002e7e82,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OCCC[Si](C)(OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/84485,PubChem,C=C(C)C(=O)OCCC[Si](C)(OC)OC,Train "EU_REACH: 2-[9-(1-hydroxy-2-methylpropan-2-yl)-2,4,8,10-tetraoxaspiro[5.5]undecan-3-yl]-2-methylpropan-1-ol",,1455-42-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13316/7/4/2/?documentUUID=1341c6fd-d38d-4e03-8829-018dcfa7c7f2,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(CO)C1OCC2(CO1)COC(OC2)C(C)(C)CO,https://pubchem.ncbi.nlm.nih.gov/compound/7569008,PubChem,CC(C)(CO)C1OCC2(CO1)COC(C(C)(C)CO)OC2,Train "KR_NCIS: 3-Bromo-2-methyl-1-propene",,1458-98-6,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CC(=C)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/357785,PubChem,C=C(C)CBr,Train "EU_REACH: 1,3-dimethyl benzene-1,3-dicarboxylate",,1459-93-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5958/7/4/2/?documentUUID=e3b922cd-7f85-4925-9f8d-87d4a63cc448,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1=CC(=CC=C1)C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/15088,PubChem,COC(=O)c1cccc(C(=O)OC)c1,Train "NZ_CCID: Isopentanoic anhydride",,1468-39-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1187330D-651B-41EB-82D3-0F71BFBE1F72,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)CC(=O)OC(=O)CC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/73847,PubChem,CC(C)CC(=O)OC(=O)CC(C)C,Train "EU_REACH: (2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxy-phenyl)methyl]quinuclidin-3-amine",,147116-67-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29628/7/4/2/?documentUUID=b9cffed0-8570-41bc-a19f-c8ee4e59ee96,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1=CC(=C(C=C1)OC)CN[C@@H]2[C@@H](N3CCC2CC3)C(C4=CC=CC=C4)C5=CC=CC=C5,https://pubchem.ncbi.nlm.nih.gov/compound/204108,PubChem,COc1ccc(C(C)(C)C)cc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1,Train "EU_REACH: Biphenyl-4,4'-diyl tetrakis(2,6-dimethylphenyl) bis(phosphate)",,147263-99-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6661/7/4/2/?documentUUID=f95aa7b0-ce0c-428b-a7e7-288ae16d74bd,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C(=CC=C1)C)OP(=O)(OC2=CC=C(C=C2)C3=CC=C(C=C3)OP(=O)(OC4=C(C=CC=C4C)C)OC5=C(C=CC=C5C)C)OC6=C(C=CC=C6C)C,https://pubchem.ncbi.nlm.nih.gov/compound/59749758,PubChem,Cc1cccc(C)c1OP(=O)(Oc1ccc(-c2ccc(OP(=O)(Oc3c(C)cccc3C)Oc3c(C)cccc3C)cc2)cc1)Oc1c(C)cccc1C,Train "AU_HCIS: 9-Octadecen-1-amine, N,N-dimethyl-, (Z)-",,14727-68-5,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5655,,,AU_HCIS,1,CCCCCCCC/C=C\CCCCCCCCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/5357010,PubChem,CCCCCCCC/C=C\CCCCCCCCN(C)C,Train "EU_REACH: 2-(4,6-diphenyl-1,3,5-triazin-2-yl)-5-(hexyloxy)phenol",,147315-50-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8654/7/4/2/?documentUUID=7f392510-0fd8-4ba0-8c65-96048ecbbea1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCOC1=CC(=C(C=C1)C2=NC(=NC(=N2)C3=CC=CC=C3)C4=CC=CC=C4)O,https://pubchem.ncbi.nlm.nih.gov/compound/4992761,PubChem,CCCCCCOc1ccc(-c2nc(-c3ccccc3)nc(-c3ccccc3)n2)c(O)c1,Train "EU_REACH: 8-[4-(3,4-difluorophenyl)cyclohex-3-en-1-yl]-1,4-dioxaspiro[4.5]decane",,147622-83-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22655/7/4/2/?documentUUID=9d9ba89e-8f2b-4f66-b70c-ee2a4bacc764,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC(=CCC1C2CCC3(CC2)OCCO3)C4=CC(=C(C=C4)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/11559061,PubChem,Fc1ccc(C2=CCC(C3CCC4(CC3)OCCO4)CC2)cc1F,Train "EU_REACH: 4-[4-trans-(3,4-Difluorophenyl)-cyclohexyl]-cyclohexanone",,147622-85-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23736/7/4/2/?documentUUID=c680dcf7-f154-4efd-8efd-66415afbf721,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC(CCC1C2CCC(=O)CC2)C3=CC(=C(C=C3)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/11493045,PubChem,O=C1CCC(C2CCC(c3ccc(F)c(F)c3)CC2)CC1,Train "JP_CHRIP: m-Xylylenediamine","JP_CHRIP: 1,3-Benzenedimethanamine 1,3-bis(aminomethyl)benzene 1,3-bis-Aminomethylbenzene m-phenylenebis(methylamine) m-Xylene alpha, alpha'-diamine m-Xylylenediamine",1477-55-0,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2009e.html,"JP_CHRIP: [Rationale for the Classification] It was classified in Category 1 from (1), (2). [Evidence Data] (1) Undiluted this substance was corrosive to the guinea pig skin, and a 50% emulsion in acetone/dioxane was severely irritating, but a 10% emulsion produced little effect. And a topical application of a 10% aqueous solution caused severe erythema and edema (ACGIH (7th, 2019)). (2) This substance is corrosive to the rat and mouse skin (SIAP (2001), REACH registration dossier (Access on May 2020)).",,JP_CHRIP,1,NCc1cccc(CN)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J38.174H,J-GLOBAL,NCc1cccc(CN)c1,Train "EU_REACH: 4-[1,1,1,3,3,3-hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenol",,1478-61-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23236/7/4/2/?documentUUID=59817356-3052-4985-9e44-a81581bfa9d4,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1C(C2=CC=C(C=C2)O)(C(F)(F)F)C(F)(F)F)O,https://pubchem.ncbi.nlm.nih.gov/compound/73864,PubChem,Oc1ccc(C(c2ccc(O)cc2)(C(F)(F)F)C(F)(F)F)cc1,Train "EU_REACH: 1,12-bis({2-[4-(4,6-diphenyl-1,3,5-triazin-2-yl)-3-hydroxyphenoxy]ethyl}) dodecanedioate",,1482217-03-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7675/7/4/2/?documentUUID=d2fc4280-abde-44f8-a035-ba6bdd459e1b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C2=NC(=NC(=N2)C3=C(C=C(C=C3)OCCOC(=O)CCCCCCCCCCC(=O)OCCOC4=CC(=C(C=C4)C5=NC(=NC(=N5)C6=CC=CC=C6)C7=CC=CC=C7)O)O)C8=CC=CC=C8,https://pubchem.ncbi.nlm.nih.gov/compound/136798548,PubChem,O=C(CCCCCCCCCCC(=O)OCCOc1ccc(-c2nc(-c3ccccc3)nc(-c3ccccc3)n2)c(O)c1)OCCOc1ccc(-c2nc(-c3ccccc3)nc(-c3ccccc3)n2)c(O)c1,Train "EU_REACH: 3-(2,4-dichlorophenyl)-2-oxo-1-oxaspiro[4.5]dec-3-en-4-yl 2,2-dimethylbutanoate JP_CHRIP: 3-(2,4-Dichlorophenyl)-2-oxo-1-oxaspiro[4.5]dec-3-en-4-yl 2,2-dimethylbutanoate; Spirodiclofen",,148477-71-8,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32995/7/4/2/?documentUUID=3c556745-0514-4711-a027-3853ca382768 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0053e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 72-hour observation), no skin irritation changes were seen (erythema/eschar score: 0/0/0, edema score: 0/0/0) (ECHA RAC Opinion (2016), CLH Report (2015), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)).",Provided,"EU_REACH, JP_CHRIP",2,CCC(C)(C)C(=O)OC1=C(C(=O)OC21CCCCC2)c1ccc(Cl)cc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.571.716E,J-GLOBAL,CCC(C)(C)C(=O)OC1=C(c2ccc(Cl)cc2Cl)C(=O)OC12CCCCC2,Train "EU_REACH: trimethoxymethane JP_CHRIP: Methyl orthoformate","JP_CHRIP: Methane, trimethoxy-",149-73-5,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14129/7/4/2/?documentUUID=532e8b32-f4c6-4afe-98b9-4174b82b785d JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0133e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: The substance was classified as ""Not classified"" based on the documented case of ""not irritating"" (IUCLID (2000)) resulted from the rabbit test (OECD TG404, GLP-compliant) in which the score of both erythema and edema was 0.",Provided,"EU_REACH, JP_CHRIP",2,COC(OC)OC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J8.664I,J-GLOBAL,COC(OC)OC,Train "NZ_CCID: Dichloromethylphenylsilane",,149-74-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FB803C7D-6313-4D30-8B48-78C1425CC6BF,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C[Si](C1=CC=CC=C1)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/9006,PubChem,C[Si](Cl)(Cl)c1ccccc1,Train "NZ_CCID: Diphenylphosphinic chloride",,1499-21-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1E404F52-F9D0-4766-A81A-9E7642B6AC09,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)P(=O)(C2=CC=CC=C2)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/73910,PubChem,O=P(Cl)(c1ccccc1)c1ccccc1,Train "JP_CHRIP: (2E)-2-[2-[(2,5-dimethylphenoxy)methyl]phenyl]-2-methoxyimino-N-methylacetamide (synonym: dimoxystrobin)",,149961-52-4,NC,JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-mhlw-0004.html,"JP_CHRIP: 【分類根拠】 （１）より、区分に該当しない。 【根拠データ】 （１）ウサギ（n = 6）を用いた皮膚刺激性試験（OECD TG 404、GLP、半閉塞、4時間適用、9日観察）において、みられた影響は8日以内に回復した（紅斑・痂皮スコア：0/0/0/0.7/1/2、浮腫スコア：0/0/0/0/0/0）との報告がある（ECHA RAC Opinion (2020)、CLH Report (2019)、EFSA (2005)）。",Provided,JP_CHRIP,1,CNC(=O)/C(=N/OC)/c1ccccc1COc1cc(C)ccc1C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.077.232J,J-GLOBAL,CNC(=O)/C(=N/OC)c1ccccc1COc1cc(C)ccc1C,Train "EU_REACH: 4-amino-3,6-dichloropyridine-2-carboxylic acid",,150114-71-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16971/7/4/2/?documentUUID=f7c869cd-5b79-4f6c-b0d4-7f0b49760b7a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(C(=C(N=C1Cl)C(=O)O)Cl)N,https://pubchem.ncbi.nlm.nih.gov/compound/213012,PubChem,Nc1cc(Cl)nc(C(=O)O)c1Cl,Train "EU_REACH: 1,4-dimethoxybenzene",,150-78-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2003/7/4/2/?documentUUID=501a3e97-e8ba-46c7-810c-f3a08864747d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC=C(C=C1)OC,https://pubchem.ncbi.nlm.nih.gov/compound/9016,PubChem,COc1ccc(OC)cc1,Train "AU_HCIS: ethyleneimine JP_CHRIP: Ethyleneimine; Aziridine (with stabilizer)","AU_HCIS: Aziridine JP_CHRIP: Azacyclopropane Dihydro-1H-azirine Ethyleneimine",151-56-4,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1998 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2083e.html","JP_CHRIP: [Rationale for the Classification] It was classified in Category 1 from (1) - (4). [Evidence Data] (1) This substance was corrosive, and contact with the skin caused erythema, skin burns, and blisters, and entry in the eye caused erythema, pain, and severe burns (Environmental Risk Assessment for Chemical Substances vol. 12 (Ministry of the Environment, 2014)). (2) In a test with rabbits, this substance caused necrosis of the skin within 1.5 hours after application and corrosion of the cornea in the eye (AICIS (formerly, NICNAS) IMAP (2014), REACH registration dossier (Access on August 2020)). (3) Skin disorder, disorder of the anterior part of the eye, disorder of the respiratory tract/lung, or disorder of the kidney caused by this substance was designated as occupational diseases listed in Appended Table 1-2 of the Ordinance for Enforcement of the Labor Standards Act (notification No. 33 (1996)). (4) This substance was strongly irritative and corrosive to the skin and mucosa (GESTIS (Access on May 2020), HSDB (Access on May 2020)). [Reference Data, etc.] (5) It was classified in Skin Corr. 1B (H314) in EU-CLP classification (EU CLP classification (Access on August 2020)).",,"AU_HCIS, JP_CHRIP",2,C1CN1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.966A,J-GLOBAL,C1CN1,Train "NZ_CCID: 1,1,1,5,5,5-Hexafluoroacetylacetone","NZ_CCID: 1,1,1,5,5,5-hexafluoro-2,4-pentanedione",1522-22-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3EC4E2FD-DD90-41BE-95CE-D75AFAD0B729,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(C(=O)C(F)(F)F)C(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/73706,PubChem,O=C(CC(=O)C(F)(F)F)C(F)(F)F,Train "EU_REACH: (3E,7E)-cyclododeca-3,7-dien-1-one; (4E,8Z)-cyclododeca-4,8-dien-1-one; (4Z,8E)-cyclododeca-4,8-dien-1-one",,15229-79-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20023/7/4/2/?documentUUID=4df1eab4-d575-4af1-b696-7480cc46d40e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC=CCCC=CCCC(=O)C1,https://pubchem.ncbi.nlm.nih.gov/compound/601176,PubChem,O=C1CCC=CCCC=CCCC1,Train "JP_CHRIP: 3-[(2-Chloro-1,3-thiazol-5-yl)methyl]-5-methyl-N-nitro-1,3,5-oxadiazinan-4-imine; Thiamethoxam",,153719-23-4,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0026e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 6) (OECD TG 404, GLP, 4-hour application, 72-hour observation), no skin reactions were seen in any animal (erythema/eschar score: 0/0/0/0/0/0, edema score: 0/0/0/0/0/0) (EU CLH report (2018), RAC Opinion (2019), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), JMPR (2010), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2018)).",Provided,JP_CHRIP,1,CN1COCN(Cc2cnc(Cl)s2)C1=N[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.067.655J,J-GLOBAL,CN1COCN(Cc2cnc(Cl)s2)C1=N[N+](=O)[O-],Train "EU_REACH: 3-methyl-N-nitro-3,6-dihydro-2H-1,3,5-oxadiazin-4-amine",,153719-38-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5312/7/4/2/?documentUUID=dc9602a3-35fe-4b79-b9bb-7c176c33a91c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN1COCN=C1N[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/10888198,PubChem,CN1COCN=C1N[N+](=O)[O-],Train "KR_NCIS: 4,4'-Methylenebis[N-(1-methylpropyl)cyclohexanamine]","KR_NCIS: Cyclohexanamine, 4,4'-methylenebis[N-(1-methylpropyl)-; N,N'-Di-sec-butyl-4,4'-methylenebis(cyclohexylamine)",154279-60-4,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCC(C)NC1CCC(CC1)CC2CCC(CC2)NC(C)CC,https://pubchem.ncbi.nlm.nih.gov/compound/21885336,PubChem,CCC(C)NC1CCC(CC2CCC(NC(C)CC)CC2)CC1,Train "NZ_CCID: 1-(Trifluoroacetyl)-1H-imidazole","NZ_CCID: 1-(trifluoroacetyl)imidazole, N-Trifluoroacetylimidazole",1546-79-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E534FC40-175A-4CDA-A0E9-E4F68A035F0A,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CN(C=N1)C(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/73767,PubChem,O=C(n1ccnc1)C(F)(F)F,Train "EU_REACH: (1r,1'r,4r,4'r)-4-ethenyl-4'-(4-methylphenyl)-1,1'-bi(cyclohexane)",,155041-85-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30138/7/4/2/?documentUUID=d45d3bd3-5011-42ca-883b-2f1941c4311c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)C2CCC(CC2)C3CCC(CC3)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/20580010,PubChem,C=CC1CCC(C2CCC(c3ccc(C)cc3)CC2)CC1,Train "EU_REACH: 2,2-difluoroethyl acetate",,1550-44-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33878/7/4/2/?documentUUID=bb3e61ae-a311-455b-8d91-060e5b10c2aa,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)OCC(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/137074,PubChem,CC(=O)OCC(F)F,Train "EU_REACH: 1-{5-[(3-chloro-2-fluorophenyl)methyl]-2,4-dimethoxyphenyl}ethan-1-one",,1551444-36-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18432/7/4/2/?documentUUID=9ba1a29e-18c3-4cd9-a28a-354d3ac2ae48,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C1=C(C=C(C(=C1)CC2=C(C(=CC=C2)Cl)F)OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/59551825,PubChem,COc1cc(OC)c(C(C)=O)cc1Cc1cccc(Cl)c1F,Train "EU_REACH: 2-(2H-1,2,3-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-(2,2,4,6,6-pentamethyl-3,5-dioxa-2,4,6-trisilaheptan-4-yl)propyl]phenol",,155633-54-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17628/7/4/2/?documentUUID=ad5a5a2b-88d4-4c69-a876-e30be14c6182,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C(=C1)N2N=C3C=CC=CC3=N2)O)CC(C)C[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/9848888,PubChem,Cc1cc(CC(C)C[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C)c(O)c(-n2nc3ccccc3n2)c1,Train "KR_NCIS: Tris(trimethylsilyl)phosphine",,15573-38-3,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C[Si](C)(C)P([Si](C)(C)C)[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/272683,PubChem,C[Si](C)(C)P([Si](C)(C)C)[Si](C)(C)C,Train "EU_REACH: 2(3H)-Benzofuranone, 5,7-bis(1,1-dimethylethyl)-3-(4-hydroxy-3,5-",,155810-87-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20257/7/4/2/?documentUUID=5728f3de-40b3-4af5-b55c-d799ff7fbf8f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=CC(=C1O)C)C2C3=C(C(=CC(=C3)C(C)(C)C)C(C)(C)C)OC2=O,https://pubchem.ncbi.nlm.nih.gov/compound/11100649,PubChem,Cc1cc(C2C(=O)Oc3c2cc(C(C)(C)C)cc3C(C)(C)C)cc(C)c1O,Train "KR_NCIS: Dichloro(chloromethyl)methylsilane",,1558-33-4,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C[Si](CCl)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/73788,PubChem,C[Si](Cl)(Cl)CCl,Train "EU_REACH: 2-[({[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}carbonyl)oxy]ethan-1-ol",,156324-78-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23541/7/4/2/?documentUUID=66308ee3-ac34-4b1c-a22d-fb6e7a9c96b2,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H]1CC[C@H]([C@@H](C1)OC(=O)OCCO)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/189860,PubChem,CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)OCCO,Train "JP_CHRIP: 3-Amino-1-propanol NZ_CCID: 3-Amino-1-propanol","JP_CHRIP: 3-amino-1-propanol",156-87-6,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0090e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8536FE88-C7C1-406F-A661-FD36BC5689B4","JP_CHRIP: It was classified in Category 1 because it was rated as 5 (corresponding to severe erythema and edema or slight necrosis) on a scale from 1 to 10 (10 being the most severe) in a test by a 24-hour open application of 0.01 mL of the undiluted substance to the rabbit skin (PATTY (5th, 2001)), and the pH of the substance was 11.6 (20 deg C, 10 g/L). NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,NCCCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.560G,J-GLOBAL,NCCCO,Train "JP_CHRIP: Propylene glycol monoethyl ether; 1-Ethoxy-2-propanol","JP_CHRIP: 2-Propanol, 1-ethoxy- 1-Ethoxy-2-propanol 2-Propanol-1-ethoxy 2PG1EE",1569-02-4,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2031e.html,"JP_CHRIP: [Rationale for the Classification] Based on (1), it was classified as ""Not classified."" [Evidence Data] (1) In a skin irritation test with rabbits equivalent or similar to OECD TG 404, slight erythema was observed at 1 and 24 hours after exposure and disappeared after 48 hours. Flaking was also noted, but it disappeared within 7 days. The mean scores for erythema and edema at 24/48/72 hours were 0-1.33 and 0, respectively (REACH registration dossier (Access on August, 2019)). [Reference Data, etc.] (2) This substance was slightly irritating to the skin of rabbits, producing minimal transient reddening and edema with slight flaking of the skin after 72 hours (ACGIH (7th, 2019)). (3) Moderate irritation was observed in skin irritation tests by 24-hour occlusive or 4-hour semi-occlusive application to rabbits (ECETOC TR64 (1995)). (4) This substance is slightly irritating to the skin (PATTY (6th, 2012)).",Provided,JP_CHRIP,1,CCOCC(C)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J13.130J,J-GLOBAL,CCOCC(C)O,Train "EU_REACH: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol",,156928-09-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25771/7/4/2/?documentUUID=d243b303-bff3-49b7-85f1-0533896984da,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CO[C@H]2[C@@H]1[C@H](CO2)O,https://pubchem.ncbi.nlm.nih.gov/compound/9942150,PubChem,O[C@H]1CO[C@H]2OCC[C@H]21,Train "JP_CHRIP: 4-chloro-o-cresol; 4-chloro-2-methyl phenol NZ_CCID: 4-Chloro-2-cresol","JP_CHRIP: para-Chloro-ortho-cresol Phenol, 4-chloro-2-methyl Phenol, 4-chloro-2-methyl- NZ_CCID: Phenol, 4-chloro-2-methyl-",1570-64-5,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0217e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/679E8707-E8D9-4012-86E4-8DC6068F8980","JP_CHRIP: In the rabbit tests (OECD TG404, GLP-compliant), the substance was evaluated to be highly irritating and its Primary Dermal Irritation Index value was 8 (which is the maximum score) (SIDS (accessed in December 2008)). In other two tests using rabbits, the substance was concluded to be corrosive (IUCLID (2000)). Based on these results, the substance was classified into Category 1. In other tests using unknown animal species, necrosis was detected 1 minute after the exposure (SIDS (accessed in December 2008), BUA (Report 134, 1993)). Although these results indicate a more refined classification of the substance into Category 1A, further classification was not considered due to lack of information on the species and quantity of animals tested. NZ_CCID: Skin Irritation R-PHRASE: R 35 Causes severe burns. [NCLASS] Eye Irritation SPECIES: Rabbit RESULT: Irritating REFERENCE SOURCE: BASF AG Ludwigshafen BASF AG, Abteilung Toxikologie; unveroeffentlichte Untersuchung (XXVI/647), 27.02.78 [IUCLID 2000] REMARK: EC classification: Risk of serious damage to eyes.",Provided,"JP_CHRIP, NZ_CCID",2,Cc1cc(Cl)ccc1O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J33.994F,J-GLOBAL,Cc1cc(Cl)ccc1O,Train "EU_REACH: 4'-ethyl-2,3-difluoro-4-(4-propylphenyl)-1,1'-biphenyl",,157248-25-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21094/7/4/2/?documentUUID=26f0d263-0620-4a22-94cd-8d378aa360e1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1=CC=C(C=C1)C2=C(C(=C(C=C2)C3=CC=C(C=C3)CC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/53649556,PubChem,CCCc1ccc(-c2ccc(-c3ccc(CC)cc3)c(F)c2F)cc1,Train "KR_NCIS: 4-(Aminomethyl)-1,8-octanediamine",,1572-55-0,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C(CCN)CC(CCCN)CN,https://pubchem.ncbi.nlm.nih.gov/compound/94211,PubChem,NCCCCC(CN)CCCN,Train "EU_REACH: 4,4'-[(3,3'-dichlorobiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis[5-methyl-2-(4-methylphenyl)-2,4-dihydro-3H-pyrazol-3-one]",,15793-73-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14131/7/4/2/?documentUUID=7653d6b2-45ae-4eab-b13e-35c2aa81a938,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)N2C(=O)C(C(=N2)C)N=NC3=C(C=C(C=C3)C4=CC(=C(C=C4)N=NC5C(=NN(C5=O)C6=CC=C(C=C6)C)C)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/85908,PubChem,CC1=NN(c2ccc(C)cc2)C(=O)C1N=Nc1ccc(-c2ccc(N=NC3C(=O)N(c4ccc(C)cc4)N=C3C)c(Cl)c2)cc1Cl,Train "EU_REACH: (2S)-1-isopropoxy-1-oxopropan-2-yl pivalate",,1584709-99-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21514/7/4/2/?documentUUID=d0cdecf9-d474-4b4e-aad8-951acd97d231,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H](C(=O)OC(C)C)OC(=O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/121317744,PubChem,CC(C)OC(=O)[C@H](C)OC(=O)C(C)(C)C,Train "AU_HCIS: Phenol, 4-nonyl-2,6-bis(1-phenylethyl)-",,15860-96-5,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6709,,,AU_HCIS,1,CCCCCCCCCC1=CC(=C(C(=C1)C(C)C2=CC=CC=C2)O)C(C)C3=CC=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/85922,PubChem,CCCCCCCCCc1cc(C(C)c2ccccc2)c(O)c(C(C)c2ccccc2)c1,Train "EU_REACH: N,N',N''-tricyclohexyl-1-methylsilanetriamine",,15901-40-3,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23897/7/4/2/?documentUUID=3d597a10-33d3-40b4-bd12-48e457a6d04e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](NC1CCCCC1)(NC2CCCCC2)NC3CCCCC3,https://pubchem.ncbi.nlm.nih.gov/compound/85178,PubChem,C[Si](NC1CCCCC1)(NC1CCCCC1)NC1CCCCC1,Train "NZ_CCID: 1,1,3,3-Tetramethyldisilazane",,15933-59-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/046FF292-9046-4B4F-9382-D4EA76F68C58,"NZ_CCID: Skin Irritation UN CLASS: 3; 8; PGII Eye Irritation UN CLASS: 3; 8; PGII",,NZ_CCID,1,C[Si](C)N[Si](C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6327317,PubChem,C[Si](C)N[Si](C)C,Train "EU_REACH: N-(5-chloro-2-methoxyphenyl) -2-[(2-methoxy-4-nitrophenyl) diazenyl]-3-oxobutanamide",,15993-42-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10410/7/4/2/?documentUUID=9982e4c8-d371-4ec9-8a46-071f80c35bdf,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=C(C=CC(=C1)Cl)OC)N=NC2=C(C=C(C=C2)[N+](=O)[O-])OC,https://pubchem.ncbi.nlm.nih.gov/compound/85940,PubChem,COc1cc([N+](=O)[O-])ccc1N=NC(C(C)=O)C(=O)Nc1cc(Cl)ccc1OC,Train "EU_REACH: 2-[2-(2-methoxyethoxy)ethoxy]acetic acid",,16024-58-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25107/7/4/2/?documentUUID=7915d090-f6b8-493c-a945-890267af5d4d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COCCOCCOCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/85241,PubChem,COCCOCCOCC(=O)O,Train "NZ_CCID: Iodotrimethylsilane","NZ_CCID: trimethylsilyl iodide",16029-98-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D9BDB066-A838-4418-BBF8-C969AE8216B8,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C[Si](C)(C)I,https://pubchem.ncbi.nlm.nih.gov/compound/85247,PubChem,C[Si](C)(C)I,Train "EU_REACH: 3-[4-(2-hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid",,16052-06-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32799/7/4/2/?documentUUID=c4e99cf8-df99-4a77-adcb-9e590c1506d0,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CN(CCN1CCCS(=O)(=O)O)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/85255,PubChem,O=S(=O)(O)CCCN1CCN(CCO)CC1,Train "EU_REACH: 4,4,7,7-tetraethoxy-3,8-dioxa-4,7-disiladecane",,16068-37-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23679/7/4/2/?documentUUID=54b63d5d-853b-48f8-8a5b-66ab86d5b0c5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](CC[Si](OCC)(OCC)OCC)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/85266,PubChem,CCO[Si](CC[Si](OCC)(OCC)OCC)(OCC)OCC,Train "KR_NCIS: 1-Bromo-3-chloro-5,5-dimethylhydantoin","KR_NCIS: 1-Bromo-3-chloro-5,5-dimethylhydantoin",16079-88-2,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CC1(C(=O)N(C(=O)N1Br)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/61828,PubChem,CC1(C)C(=O)N(Cl)C(=O)N1Br,Train "EU_REACH: N-phenyl-N-piperidin-4-ylpropionamide",,1609-66-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20255/7/4/2/?documentUUID=214b9c45-1f8f-4bfd-9c17-f3f5d60f4e61,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(=O)N(C1CCNCC1)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/259381,PubChem,CCC(=O)N(c1ccccc1)C1CCNCC1,Train "KR_NCIS: tert-Butyl isocyanate",,1609-86-5,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CC(C)(C)N=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/62412,PubChem,CC(C)(C)N=C=O,Train "EU_REACH: ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate",,161797-99-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18541/7/4/2/?documentUUID=467abe53-de99-4235-8031-0a59623d036f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1=C(N=C(S1)C2=CC=C(C=C2)O)C,https://pubchem.ncbi.nlm.nih.gov/compound/135509402,PubChem,CCOC(=O)c1sc(-c2ccc(O)cc2)nc1C,Train "EU_REACH: propan-2-yl (1R,3S,4R,5R)-3-azido-5-hydroxy-4-{[(2S,3S,4R,5R,6S)-3,4,5-tris(benzyloxy)-6-methyloxan-2-yl]oxy}cyclohexane-1-carboxylate",,1620677-97-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18013/7/4/2/?documentUUID=77e567d8-9577-4ea6-a136-e8ddc1bf8848,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@H]1[C@H]([C@H]([C@@H]([C@@H](O1)O[C@@H]2[C@H](C[C@H](C[C@H]2O)C(=O)OC(C)C)N=[N+]=[N-])OCC3=CC=CC=C3)OCC4=CC=CC=C4)OCC5=CC=CC=C5,https://pubchem.ncbi.nlm.nih.gov/compound/154734785,PubChem,CC(C)OC(=O)[C@H]1C[C@@H](O)[C@H](O[C@@H]2O[C@@H](C)[C@@H](OCc3ccccc3)[C@@H](OCc3ccccc3)[C@@H]2OCc2ccccc2)[C@@H](N=[N+]=[N-])C1,Train "EU_REACH: 1,1,1,2,2,3,3-heptafluoro-3-[(1,2,2-trifluoroethenyl)oxy]propane",,1623-05-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23696/7/4/2/?documentUUID=d1525b16-81a4-45fa-ab8d-58c0127cb8a6,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(=C(F)F)(OC(C(C(F)(F)F)(F)F)(F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/15388,PubChem,FC(F)=C(F)OC(F)(F)C(F)(F)C(F)(F)F,Train "AU_HCIS: Phosphoric acid, monobutyl ester",,1623-15-0,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6801,,,AU_HCIS,1,CCCCOP(=O)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/15389,PubChem,CCCCOP(=O)(O)O,Train "EU_REACH: 2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoic acid",,162537-11-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19495/7/4/2/?documentUUID=cbf62ac8-d90b-45c6-8a96-619549084d30,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)[C@@H](C(=O)O)NC(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/11263950,PubChem,COC(=O)N[C@H](C(=O)O)C(C)(C)C,Train "EU_REACH: 5-[3-(1-ethoxyethoxy)-3-methyl-4-penten-1-ynyl]-2,4,6,6-tetramethyl-5,6,7,7a-tetrahydro-1,3-benzodioxol-5-ol",,162691-59-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17392/7/4/2/?documentUUID=b70962ba-3165-4234-9a3c-bbdca7604049,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(C)OC(C)(C=C)C#CC1(C(=C2C(CC1(C)C)OC(O2)C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/11132254,PubChem,C=CC(C)(C#CC1(O)C(C)=C2OC(C)OC2CC1(C)C)OC(C)OCC,Train "EU_REACH: 3-(trimethoxysilyl)propyl (2E,4E)-hexa-2,4-dienoate",,163802-53-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10924/7/4/2/?documentUUID=c9dbab23-fa0f-483e-975c-6e96040e747b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C/C=C/C=C/C(=O)OCCC[Si](OC)(OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/58361202,PubChem,C/C=C/C=C/C(=O)OCCC[Si](OC)(OC)OC,Train "EU_REACH: ethyl 3-[(3R)-3-{[(1S)-1-phenylethyl]amino}-2,3,4,9-tetrahydro-1H-carbazol-9-yl]propanoate",,1638586-33-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17128/7/4/2/?documentUUID=545a8033-73e7-481d-b5af-53d1c3534088,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)CCN1C2=C(C[C@@H](CC2)N[C@@H](C)C3=CC=CC=C3)C4=CC=CC=C41,https://pubchem.ncbi.nlm.nih.gov/compound/154734788,PubChem,CCOC(=O)CCn1c2c(c3ccccc31)C[C@H](N[C@@H](C)c1ccccc1)CC2,Train "EU_REACH: p-Nitrobenzoic acid-2-ethylhexylester",,16397-70-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7389/7/4/2/?documentUUID=e1fd1080-6a50-4ab9-8c20-84e20962c1b5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)C1=CC=C(C=C1)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/591313,PubChem,CCCCC(CC)COC(=O)c1ccc([N+](=O)[O-])cc1,Train "EU_REACH: N,N',N''-tributyl-1-methylsilanetriamine",,16411-33-9,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23686/7/4/2/?documentUUID=583023cc-f067-475d-95dc-be3ca2cd1d81,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCN[Si](C)(NCCCC)NCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/85403,PubChem,CCCCN[Si](C)(NCCCC)NCCCC,Train "EU_REACH: 1,1,1,2,2,3,3-heptafluoro-3-({1,1,1,2,3,3-hexafluoro-3-[(1,2,2-trifluoroethenyl)oxy]propan-2-yl}oxy)propane",,1644-11-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24699/7/4/2/?documentUUID=e315d2e3-5c18-412c-a432-fccd6c44b36c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(=C(F)F)(OC(C(C(F)(F)F)(OC(C(C(F)(F)F)(F)F)(F)F)F)(F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/102662,PubChem,FC(F)=C(F)OC(F)(F)C(F)(OC(F)(F)C(F)(F)C(F)(F)F)C(F)(F)F,Train "EU_REACH: N-[3-(diethylamino)propyl]-4-[(1E)-2-{2-oxo-1-[(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl)carbamoyl]propyl}diazen-1-yl]benzamide",,164578-14-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31229/7/4/2/?documentUUID=7033ee1c-16aa-42e8-88b8-6ab9166e6c35,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN(CC)CCCNC(=O)C1=CC=C(C=C1)N=NC(C(=O)C)C(=O)NC2=CC3=C(C=C2)NC(=O)N3,https://pubchem.ncbi.nlm.nih.gov/compound/57490352,PubChem,CCN(CC)CCCNC(=O)c1ccc(N=NC(C(C)=O)C(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)cc1,Train "EU_REACH: 3-butoxypropylamine KR_NCIS: 3-Butoxypropylamine",,16499-88-0,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26854/7/4/2/?documentUUID=b2bb62df-5dda-44e6-a4bf-c1b79e65f760 KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,"EU_REACH, KR_NCIS",2,CCCCOCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/85461,PubChem,CCCCOCCCN,Train "EU_REACH: 3-butyl-2-(heptan-3-yl)-1,3-oxazolidine",,165101-57-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10626/7/4/2/?documentUUID=d62fc6b0-d89f-4d41-828b-dd25d80f7445,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)C1N(CCO1)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/3297025,PubChem,CCCCC(CC)C1OCCN1CCCC,Train "EU_REACH: 1-(cyclopropylmethyl)-4-methoxybenzene",,16510-27-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/9760/7/4/2/?documentUUID=4630094e-73e7-4c87-8220-1f67e6c4459c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC=C(C=C1)CC2CC2,https://pubchem.ncbi.nlm.nih.gov/compound/6422476,PubChem,COc1ccc(CC2CC2)cc1,Train "EU_REACH: (2S)-2-[(1S,2R,6S,14R,15R,16R)-3-(cyclopropylmethyl)-11,15-dimethoxy-13-oxa-3-azahexacyclo[13.2.2.1²,⁸.0¹,⁶.0⁶,¹⁴.0⁷,¹²]icosa-7,9,11-trien-16-yl]-3,3-dimethylbutan-2-ol",,16524-65-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24919/7/4/2/?documentUUID=66cdde11-6486-4711-a325-dcf65d7cd412,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@]([C@H]1C[C@@]23CC[C@@]1([C@H]4[C@@]25CCN([C@@H]3CC6=C5C(=C(C=C6)OC)O4)CC7CC7)OC)(C(C)(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/14949395,PubChem,COc1ccc2c3c1O[C@H]1[C@@]4(OC)CC[C@@]5(C[C@@H]4[C@](C)(O)C(C)(C)C)[C@@H](C2)N(CC2CC2)CC[C@]315,Train "JP_CHRIP: 1-Methyl-2-nitro-3-[(3-tetrahydrofuryl)methyl]guanidine; Dinotefuran",,165252-70-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0033e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 6) (OECD TG 404, GLP, 4-hour application, 72-hour observation), very slight erythema was observed in 3 animals at 30 minutes after the removal of patches and one after 24 hours but fully disappeared after 48 hours (erythema/eschar score: 0/0/0/0/0/0.3, edema score: 0/0/0/0/0/0) (JMPR (2012), REACH registration dossier (Accessed Sep. 2020), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2018)).",Provided,JP_CHRIP,1,CNC(=N[N+](=O)[O-])NCC1CCOC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.067.656H,J-GLOBAL,CNC(=N[N+](=O)[O-])NCC1CCOC1,Train "NZ_CCID: Malonyl dichloride",,1663-67-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AA6C7B98-3DE8-4579-8893-44387327F857,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(C(=O)Cl)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/74269,PubChem,O=C(Cl)CC(=O)Cl,Train "EU_REACH: docosyl methacrylate",,16669-27-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20681/7/4/2/?documentUUID=dc913f52-456e-4844-96b6-92e6a9d2bedb,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCCCCCCCOC(=O)C(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/3034258,PubChem,C=C(C)C(=O)OCCCCCCCCCCCCCCCCCCCCCC,Train "JP_CHRIP: Ethephon",,16672-87-0,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0056e.html,"JP_CHRIP: Because corrosive to this substance proven by spots of necrosis and edema in 4 out of 6 animals and contact erythema in 6 animals observed after an application of 0.5 mL of a water solution to rabbit skins for one to four hours was reported (JMPR 861 (1993)), and a pH about 1 of this substance was described (Sax (11th, 2004)), it was classified in Category 1.",,JP_CHRIP,1,OP(=O)(O)CCCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.864C,J-GLOBAL,O=P(O)(O)CCCl,Train "EU_REACH: Phosphinic acid, P-[3-(acetyloxy)-3-cyanopropyl]-P-methyl-, butyl ester",,167004-78-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33703/7/4/2/?documentUUID=af43a141-1efb-4780-8579-e2446274c9e2,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOP(=O)(C)CCC(C#N)OC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/44145865,PubChem,CCCCOP(C)(=O)CCC(C#N)OC(C)=O,Train "EU_REACH: methyl (2E)-2-{2-[(2,5-dimethylphenoxy)methyl]phenyl}-2-(methoxyimino)acetate",,167374-38-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/3001/7/4/2/?documentUUID=57915678-b8b6-4599-b33e-1a748f35c6d5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)C)OCC2=CC=CC=C2/C(=N\OC)/C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/15346094,PubChem,CO/N=C(/C(=O)OC)c1ccccc1COc1cc(C)ccc1C,Train "EU_REACH: (E)-[1-(methylsulfanyl)ethylidene]amino N-methylcarbamate JP_CHRIP: Methomyl","JP_CHRIP: Ethanimidothioic acid, N-[[(methylamino)carbonyl]oxy]-, methyl ester Ethanimidothioic acid, N-{{(methylamino)carbonyl}oxy}-, methyl ester Methomyl Methyl N-{(methylamino)carbonyloxy}ethanimidothioate S-Methyl N-[(methylcarbamoyl)oxy]thioacetimidate S-Methyl-N-(methylcarbamoyloxy)thioacetimidate",16752-77-5,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30946/7/4/2/?documentUUID=9bcc0e07-b791-4676-aa55-4e97a83a2aa9 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0613e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: Since it was judged to have no stimulativeness in the skin irritation test on rabbits (Agricultural-Chemicals abstracts), it was classified as out of Category.",Provided,"EU_REACH, JP_CHRIP",2,CNC(=O)ON=C(C)SC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.448G,J-GLOBAL,CNC(=O)ON=C(C)SC,Train "JP_CHRIP: Ethylcyclohexane","JP_CHRIP: ethylcyclohexane",1678-91-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2085e.html,"JP_CHRIP: [Rationale for the Classification] Based on (1), it was classified as ""Not classified."" [Evidence Data] (1) In a skin irritation test with rabbits according to OECD TG 404, the mean scores at 24/48/72 hours were all 0 (REACH registration dossier (Access on October 2019)).",Provided,JP_CHRIP,1,CCC1CCCCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J43.538D,J-GLOBAL,CCC1CCCCC1,Train "EU_REACH: dioctyl carbonate",,1680-31-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15695/7/4/2/?documentUUID=48a24014-6376-47af-9773-923c0d6e361a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCOC(=O)OCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/9904000,PubChem,CCCCCCCCOC(=O)OCCCCCCCC,Train "NZ_CCID: 2-Tetrahydrofuran carboxylic acid","NZ_CCID: tetrahydro-2-furoic acid",16874-33-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3D6E1095-7C05-4064-9177-91971EC9E225,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CC(OC1)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/86079,PubChem,O=C(O)C1CCCO1,Train "EU_REACH: 3,3-dimethylbutyryl chloride",,1694-31-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19761/7/4/2/?documentUUID=be28c706-2489-4494-9c34-a3dddf7f9fec,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)CC(=O)OC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/15538,PubChem,CC(=O)CC(=O)OC(C)(C)C,Train "EU_REACH: N-(2-ethylhexyl)-3,5,5-trimethylhexanamide",,1700656-13-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25255/7/4/2/?documentUUID=cf3d0bcb-e582-420a-a487-1dfbe0598e96,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)CNC(=O)CC(C)CC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/154734376,PubChem,CCCCC(CC)CNC(=O)CC(C)CC(C)(C)C,Train "EU_REACH: N,N'-dibutyl-N,N'-bis(1,2,2,6,6-pentamethylpiperidin-4-yl)-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamine",,1702355-94-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18891/7/4/2/?documentUUID=f36e9c5a-0d0e-4819-82d6-57bdaae7e380,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCN(C1CC(N(C(C1)(C)C)C)(C)C)C2=NC(=NC(=N2)N3CCCC3)N(CCCC)C4CC(N(C(C4)(C)C)C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/118030570,PubChem,CCCCN(c1nc(N2CCCC2)nc(N(CCCC)C2CC(C)(C)N(C)C(C)(C)C2)n1)C1CC(C)(C)N(C)C(C)(C)C1,Train "EU_REACH: 3-{2,2,6,6-tetramethyl-4-[(trimethylsilyl)oxy]-3,5-dioxa-2,4,6-trisilaheptan-4-yl}propyl 2-methylprop-2-enoate",,17096-07-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23711/7/4/2/?documentUUID=fee2c1a3-d0f1-4cec-b4e5-5c8104689bf8,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OCCC[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/123371,PubChem,C=C(C)C(=O)OCCC[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C,Train "NZ_CCID: 3-Fluorobenzoyl chloride",,1711-07-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/937B3B2E-B785-480B-9E17-5A3E585C18AD,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)F)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/74376,PubChem,O=C(Cl)c1cccc(F)c1,Train "NZ_CCID: 3-Bromobenzoyl chloride",,1711-09-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E0E6A273-F72D-4F5E-A4B6-A3FE2D971A11,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC(=CC(=C1)Br)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/74377,PubChem,O=C(Cl)c1cccc(Br)c1,Train "NZ_CCID: Dichlorodiethylsilane",,1719-53-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/180592D1-B3B7-4D90-8594-903EEA3BFF4A,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC[Si](CC)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/15589,PubChem,CC[Si](Cl)(Cl)CC,Train "NZ_CCID: Chloromethyldimethylchlorosilane","NZ_CCID: chloro(chloromethyl)dimethylsilane",1719-57-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6707F26B-1C8A-4A5C-A208-095EF77C8BA1,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C[Si](C)(CCl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/74393,PubChem,C[Si](C)(Cl)CCl,Train "KR_NCIS: Chloroethenyldimethylsilane",,1719-58-0,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C[Si](C)(C=C)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/519368,PubChem,C=C[Si](C)(C)Cl,Train "EU_REACH: 4'-[(diphenoxyphosphoryl)oxy]-[1,1'-biphenyl]-4-yl diphenyl phosphate",,17270-01-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7393/7/4/2/?documentUUID=bc5e1914-9bf3-4efa-ac12-74a69001a9f6,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)OP(=O)(OC2=CC=CC=C2)OC3=CC=C(C=C3)C4=CC=C(C=C4)OP(=O)(OC5=CC=CC=C5)OC6=CC=CC=C6,https://pubchem.ncbi.nlm.nih.gov/compound/12039854,PubChem,O=P(Oc1ccccc1)(Oc1ccccc1)Oc1ccc(-c2ccc(OP(=O)(Oc3ccccc3)Oc3ccccc3)cc2)cc1,Train "EU_REACH: (6-hydroxynaphthalen-2-yl)boronic acid",,173194-95-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7159/7/4/2/?documentUUID=c8ddcecd-5cb7-4fd8-972c-5ae9a1603e77,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,B(C1=CC2=C(C=C1)C=C(C=C2)O)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/4349738,PubChem,OB(O)c1ccc2cc(O)ccc2c1,Train "EU_REACH: (2-methylpropylidene)[(3-{[(2-methylpropylidene)amino]methyl}cyclohexyl)methyl]amine",,173904-11-5,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10659/7/4/2/?documentUUID=1a0a4d88-2e1e-49e5-b49b-f5b1940eda8e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C=NCC1CCCC(C1)CN=CC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/132472057,PubChem,CC(C)C=NCC1CCCC(CN=CC(C)C)C1,Train "EU_REACH: 2-methylbenzene-1,4-diyl bis{4-[3-(acryloyloxy)propoxy]benzoate}",,174063-87-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29950/7/4/2/?documentUUID=6ab5bfec-2f9e-4047-8fd2-06fa4d475b38,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=CC(=C1)OC(=O)C2=CC=C(C=C2)OCCCOC(=O)C=C)OC(=O)C3=CC=C(C=C3)OCCCOC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/20807398,PubChem,C=CC(=O)OCCCOc1ccc(C(=O)Oc2ccc(OC(=O)c3ccc(OCCCOC(=O)C=C)cc3)c(C)c2)cc1,Train "EU_REACH: 1-ethoxy-2,3-difluoro-4-[(1s,4r)-4-propylcyclohexyl]benzene",,174350-05-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22010/7/4/2/?documentUUID=b03e0835-e5a6-4dd7-9cde-27d5258675e0,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1CCC(CC1)C2=C(C(=C(C=C2)OCC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/19103501,PubChem,CCCC1CCC(c2ccc(OCC)c(F)c2F)CC1,Train "EU_REACH: 1-decene, dimer",,17438-89-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8881/7/4/2/?documentUUID=9cd8b6fc-263b-411c-97f9-6ec1b4470871,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCC(C)CCCCCCCCC=C,https://pubchem.ncbi.nlm.nih.gov/compound/22833390,PubChem,C=CCCCCCCCCC(C)CCCCCCCC,Train "NZ_CCID: 2-Allylphenol",,1745-81-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4EBAEBCF-4296-43C2-B256-AF9086D8652C,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C=CCC1=CC=CC=C1O,https://pubchem.ncbi.nlm.nih.gov/compound/15624,PubChem,C=CCc1ccccc1O,Train "AU_HCIS: Phenol, 4,4'-(1-methylethylidene)bis[2-(2-propen-1-yl)-",,1745-89-7,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3454,,,AU_HCIS,1,CC(C)(C1=CC(=C(C=C1)O)CC=C)C2=CC(=C(C=C2)O)CC=C,https://pubchem.ncbi.nlm.nih.gov/compound/74457,PubChem,C=CCc1cc(C(C)(C)c2ccc(O)c(CC=C)c2)ccc1O,Train "EU_REACH: 4-amino-N-(4-amino-6-oxo-5H-pyrimidin-2-yl)benzenesulfonamide",,174863-37-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21336/7/4/2/?documentUUID=47955e99-4209-49c5-9230-05b3ec16b723,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C(=N/C(=N\S(=O)(=O)C2=CC=C(C=C2)N)/NC1=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/154734778,PubChem,NC1=N/C(=N\S(=O)(=O)c2ccc(N)cc2)NC(=O)C1,Train "EU_REACH: 1-{5-[(dimethylcarbamoyl)amino]-2-methylphenyl}-3,3-dimethylurea",,17526-94-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12195/7/4/2/?documentUUID=e168413b-bde9-47e4-a819-5659befded08,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)NC(=O)N(C)C)NC(=O)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/87146,PubChem,Cc1ccc(NC(=O)N(C)C)cc1NC(=O)N(C)C,Train "EU_REACH: 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl prop-2-enoate",,17527-29-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15839/7/4/2/?documentUUID=c172a224-99fa-41ee-9fd0-f9c5617d6df9,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CC(=O)OCCC(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/87149,PubChem,C=CC(=O)OCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train "EU_REACH: 3-phenyl-2-(undec-10-enamido)propanoic acid",,175357-18-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23617/7/4/2/?documentUUID=46a1e8f4-7984-45dc-828a-2221f2774f58,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CCCCCCCCCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/10308702,PubChem,C=CCCCCCCCCC(=O)N[C@@H](Cc1ccccc1)C(=O)O,Train "NZ_CCID: Cyclopropanecarboxylic acid",,1759-53-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9BE7C48D-3217-4B2E-BED8-C702045223CB,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CC1C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/15655,PubChem,O=C(O)C1CC1,Train "EU_REACH: N-(3-(trimethoxysilyl)propyl)ethylenediamine",,1760-24-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15039/7/4/2/?documentUUID=02a7bb66-dbb2-444c-ab0d-344e7246e75d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CO[Si](CCCNCCN)(OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/15659,PubChem,CO[Si](CCCNCCN)(OC)OC,Train "JP_CHRIP: 4,4'-Methylenebis(cyclohexan-1-amine) NZ_CCID: Cyclohexanamine, 4,4'-methylenebis-","JP_CHRIP: Bis (4-aminocyclohexyl) methane NZ_CCID: Bis(4)aminocyclohexyl)methane, Bis(p–aminocyclohexyl)methane, Dicyclohexylmethane–4,4’–diamine",1761-71-3,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-0025e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E513BE0A-1513-427F-97F8-9EC909608C6F","JP_CHRIP: [Rationale for the Classification] Based on (1)-(3), it was classified in Category 1B-C. [Evidence Data] (1) In a skin irritation test with rabbits according to OECD TG 404, the 3-minute exposure did not result in necrosis at the 1-hour observation period, but one out of three animals exhibited necrosis at the 24-hour observation. The 2.75-hour exposure resulted in necrosis by the 1-hour post exposure observation (REACH registration dossier (Access on November 2019)). (2) This substance is considered to be severely irritating to corrosive to the skin and eyes (GESTIS (Access on September 2019)). (3) This substance is also considered to be corrosive since all of its analogues are corrosive substances (SIDS (2016)). NZ_CCID: Skin Irritation SPECIES: Guinea pig RESULT: 10% and 5% solutions resulted in strong irritation to intact skin in young animals. REFERENCE SOURCE: http://yosemite.epa.gov/oppts/epatscat8.nsf/ReportSearchView/F6677772F9B9C1418525693100226A82 REMARK: Strong irritant at 10% indicates more severe effect at higher concentration. Eye Irritation SPECIES: Rabbit RESULT: Corrosive REFERENCE SOURCE: http://yosemite.epa.gov/oppts/epatscat8.nsf/ReportSearchView/03647C452583AA1985256930004CD220",Provided,"JP_CHRIP, NZ_CCID",2,NC1CCC(CC2CCC(N)CC2)CC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J47.629C,J-GLOBAL,NC1CCC(CC2CCC(N)CC2)CC1,Train "EU_REACH: ethylsilanetriyl triacetate JP_CHRIP: Ethyltriacetoxysilane","JP_CHRIP: Ethyltriacetoxysilane; Ethyltriacetoxysilane",17689-77-9,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14224/7/4/2/?documentUUID=583ebd6f-e316-4a5c-9fec-774e43c3f640 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0042e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: In a test by a 3-minute semi-occlusive application of 0.5 mL of undiluted this substance to the rabbit skin, severe lesions were observed 72 hours after the application in four out of six animals, and reversibility was slight during a 14-day observation period. And the primary dermal irritation index (PDII) was 4.28, and it was judged as corrosive (SIDS (2005)). Therefore, it was classified in Category 1.",Provided,"EU_REACH, JP_CHRIP",2,CC[Si](OC(=O)C)(OC(=O)C)OC(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J266.800I,J-GLOBAL,CC[Si](OC(C)=O)(OC(C)=O)OC(C)=O,Train "EU_REACH: 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid",,176969-34-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12337/7/4/2/?documentUUID=9ab01da2-b5d5-42aa-b51e-a3570844b822,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN1C=C(C(=N1)C(F)F)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/18983008,PubChem,Cn1cc(C(=O)O)c(C(F)F)n1,Train "EU_REACH: methyl [(2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl]carbamate",,176972-62-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6302/7/4/2/?documentUUID=fbab6cf7-3408-4a13-b48a-5c95fa1b187e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)N[C@@H](CC1=CC=CC=C1)[C@@H](CCl)O,https://pubchem.ncbi.nlm.nih.gov/compound/10945089,PubChem,COC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CCl,Train "EU_REACH: 2-methoxy-10H-phenothiazine",,1771-18-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18877/7/4/2/?documentUUID=d52ea796-139f-4ca5-9341-86f48d013d64,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC2=C(C=C1)SC3=CC=CC=C3N2,https://pubchem.ncbi.nlm.nih.gov/compound/74490,PubChem,COc1ccc2c(c1)Nc1ccccc1S2,Train "EU_REACH: 3-hydroxy-2-(3-hydroxyquinolin-2-yl)-1H-inden-1-one",,17772-51-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10225/7/4/2/?documentUUID=8c22e3cc-9c68-4c11-aa56-1a69e0807943,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)C=C(C(=N2)C3=C(C4=CC=CC=C4C3=O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/87299,PubChem,O=C1C(c2nc3ccccc3cc2O)=C(O)c2ccccc21,Train "EU_REACH: 9-Octadecenamide, N-[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl]-, (9Z)-",,178436-06-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24072/7/4/2/?documentUUID=2a18d699-2eed-4056-b1b5-be6ff166fd1b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCC[C@H]([C@H]([C@H](CO)NC(=O)CCCCCCC/C=C\CCCCCCCC)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/57378373,PubChem,CCCCCCCC/C=C\CCCCCCCC(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC,Train "EU_REACH: Pentaerythritoltetracyanoacetic ester",,178671-69-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12629/7/4/2/?documentUUID=5a0e01a6-c304-49f2-a55d-0587150dd0c9,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(C#N)C(=O)OCC(COC(=O)CC#N)(COC(=O)CC#N)COC(=O)CC#N,https://pubchem.ncbi.nlm.nih.gov/compound/6850853,PubChem,N#CCC(=O)OCC(COC(=O)CC#N)(COC(=O)CC#N)COC(=O)CC#N,Train "JP_CHRIP: Dichloroethylsilane","JP_CHRIP: Ethyldichlorosilane",1789-58-8,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0089e.html,"JP_CHRIP: The substance is a severe irritant to skin (HSDB (2003)). Application of chlorosilanes to the skin of rabbits resulted in blanches and blisters in the treated area and the action was more marked the damper surface of skin (HSDB (2003)). The substance was classified into Category 1.",,JP_CHRIP,1,CC[SiH](Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J36.476B,J-GLOBAL,CC[SiH](Cl)Cl,Train "EU_REACH: 2,2,4,6,6-pentamethyl-4-octyl-3,5-dioxa-2,4,6-trisilaheptane",,17955-88-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21797/7/4/2/?documentUUID=e25caba2-0aa8-472a-845a-a45b03825cdb,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCC[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/87373,PubChem,CCCCCCCC[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C,Train "EU_REACH: 5,7-Di-t-butyl-3-[3,5-dimethyl-4-[(1,3,7,9-tetra-t-butyl-5-methyl-5H-benzo[d][1,3,2]benzodioxaphosphocin-11-yl)oxy]phenyl]-3H-benzofuran-2-one",,1803088-15-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21782/7/4/2/?documentUUID=bd1483e8-618e-4800-9977-cce71a4ccf98,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1C2=C(C(=CC(=C2)C(C)(C)C)C(C)(C)C)OP(OC3=C1C=C(C=C3C(C)(C)C)C(C)(C)C)OC4=C(C=C(C=C4C)C5C6=C(C(=CC(=C6)C(C)(C)C)C(C)(C)C)OC5=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/118320794,PubChem,Cc1cc(C2C(=O)Oc3c2cc(C(C)(C)C)cc3C(C)(C)C)cc(C)c1OP1Oc2c(cc(C(C)(C)C)cc2C(C)(C)C)C(C)c2cc(C(C)(C)C)cc(C(C)(C)C)c2O1,Train "EU_REACH: (3S)-5-fluoro-3-methyl-1,3-dihydro-2-benzofuran-1-one",,1803573-19-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18294/7/4/2/?documentUUID=bcb7b050-60c2-4f35-8aa2-d11e0f0d9682,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@H]1C2=C(C=CC(=C2)F)C(=O)O1,https://pubchem.ncbi.nlm.nih.gov/compound/134970125,PubChem,C[C@@H]1OC(=O)c2ccc(F)cc21,Train "EU_REACH: tert-butyl N-{5-bromo-3-[(4-methylbenzenesulfonyl)oxy]pyridin-2-yl}-N-[(tert-butoxy)carbonyl]carbamate",,1803573-21-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16687/7/4/2/?documentUUID=3a4422f8-434c-4ae9-88e3-53fdc213f0ef,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)S(=O)(=O)OC2=C(N=CC(=C2)Br)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/134963154,PubChem,Cc1ccc(S(=O)(=O)Oc2cc(Br)cnc2N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1,Train "EU_REACH: 1,1,2,2,3,3,4,4,5-Nonafluoro-5-(trifluoromethyl)cyclopentane",,1805-22-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24156/7/4/2/?documentUUID=010631c8-2779-4d50-a205-1c985246337c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1(C(C(C(C1(F)F)(F)F)(F)F)(F)F)(C(F)(F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/74546,PubChem,FC(F)(F)C1(F)C(F)(F)C(F)(F)C(F)(F)C1(F)F,Train "AU_HCIS: Phenol, 4-octyl-",,1806-26-4,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5803,,,AU_HCIS,1,CCCCCCCCC1=CC=C(C=C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/15730,PubChem,CCCCCCCCc1ccc(O)cc1,Train "EU_REACH: 5-[(E)-2-(benzenesulfonyl)ethenyl]-3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-1H-indole",,180637-89-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20535/7/4/2/?documentUUID=a3080f08-ecdb-4dc5-8f55-c2c590221cd0,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN1CCC[C@@H]1CC2=CNC3=C2C=C(C=C3)/C=C/S(=O)(=O)C4=CC=CC=C4,https://pubchem.ncbi.nlm.nih.gov/compound/15840036,PubChem,CN1CCC[C@@H]1Cc1c[nH]c2ccc(/C=C/S(=O)(=O)c3ccccc3)cc12,Train "EU_REACH: (chloromethyl)(methoxy)dimethylsilane",,18143-33-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1316/7/4/2/?documentUUID=249cb383-0192-4cfd-a259-c958aaa66050,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CO[Si](C)(C)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/560623,PubChem,CO[Si](C)(C)CCl,Train "EU_REACH: 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(ethanesulfinyl)-1H-pyrazole-3-carbonitrile JP_CHRIP: 5-Amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-ethylsulfinyl-1H-pyrazole-3-carbonitrile [ethiprole]","JP_CHRIP: Ethiprole",181587-01-9,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5874/7/4/2/?documentUUID=c6528b1b-8fee-49fc-aff8-a816b05de647 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-meti-0010e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: It is reported that in a skin irritation test using rabbits applied 500 mg this substance, it was not irritating due to no skin reaction observed during a 72-hour observation period (Pesticide abstract (2015); Pesticide evaluation report, Food Safety Commission of Japan (2014)). From the above, the substance was classified as ""Not classified.""",Provided,"EU_REACH, JP_CHRIP",2,CCS(=O)c1c(N)n(nc1C#N)c1c(Cl)cc(cc1Cl)C(F)(F)F,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.979.586A,J-GLOBAL,CCS(=O)c1c(C#N)nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c1N,Train "EU_REACH: tert-butyl(chloro)dimethylsilane NZ_CCID: Silane, t-butylchlorodimethyl-","NZ_CCID: tert-Butyldimethylchlorosilane, tert-butyldimethylsilyl chloride",18162-48-6,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/28118/7/4/2/?documentUUID=143e28ba-806d-4c4a-bc42-d80292321842 NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0E55EE36-D961-4EAA-A049-E58C4527B235","EU_REACH: Experimental study (OECD TG 404, GLP) NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",Provided,"EU_REACH, NZ_CCID",2,CC(C)(C)[Si](C)(C)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/28928,PubChem,CC(C)(C)[Si](C)(C)Cl,Train "EU_REACH: 4-{[diethoxy(methyl)silyl]methyl}morpholine",,18162-75-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20090/7/4/2/?documentUUID=22c5b67a-0a58-4d1a-94e4-15e557c12a8a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](C)(CN1CCOCC1)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/23065785,PubChem,CCO[Si](C)(CN1CCOCC1)OCC,Train "EU_REACH: 9,9-bis(methoxymethyl)-9H-fluorene",,182121-12-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26973/7/4/2/?documentUUID=fc1be520-0fcb-464c-9e77-28eae3cddf08,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COCC1(C2=CC=CC=C2C3=CC=CC=C31)COC,https://pubchem.ncbi.nlm.nih.gov/compound/11054211,PubChem,COCC1(COC)c2ccccc2-c2ccccc21,Train "NZ_CCID: Bis(trimethylsilyl) sulphate",,18306-29-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8D4A9ADF-9002-4B9E-8F37-5D75E4EF4D55,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C[Si](C)(C)OS(=O)(=O)O[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/87573,PubChem,C[Si](C)(C)OS(=O)(=O)O[Si](C)(C)C,Train "EU_REACH: 5-bromo-1H-pyrrolo[2,3-b]pyridine",,183208-35-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6677/7/4/2/?documentUUID=0aa0f16c-0959-4058-b1ce-9f149f5cba5f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CNC2=NC=C(C=C21)Br,https://pubchem.ncbi.nlm.nih.gov/compound/10307932,PubChem,Brc1cnc2[nH]ccc2c1,Train "EU_REACH: (14S)-4-bromo-2-methoxy-7-methyl-17-oxa-7-azatetracyclo[12.2.1.0^{5,16}.0^{10,15}]heptadeca-1,3,5(16),10-tetraen-12-one hydrochloride",,183487-56-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25323/7/4/2/?documentUUID=5b836527-99b9-44ae-b6d4-3af3fc62e5d9,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN1CC[C@@]23C=CC(=O)C[C@@H]2OC4=C3C(=C(C=C4OC)Br)C1,https://pubchem.ncbi.nlm.nih.gov/compound/11143024,PubChem,COc1cc(Br)c2c3c1O[C@H]1CC(=O)C=C[C@@]31CCN(C)C2,Train "JP_CHRIP: 1-Methyl-N-[2-(4-methylpentan-2-yl)-3-thienyl]-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide; Penthiopyrad",,183675-82-3,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0080e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, occlusive, 4-hour application, 72-hour observation), no irritation changes were seen in any animal (erythema/eschar score: 0/0/0, edema score: 0/0/0) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2019), ECHA RAC Opinion (2015), CLH Report (2015), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2013)).",Provided,JP_CHRIP,1,CC(C)CC(C)c1sccc1NC(=O)c1cn(C)nc1C(F)(F)F,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.036.571D,J-GLOBAL,CC(C)CC(C)c1sccc1NC(=O)c1cn(C)nc1C(F)(F)F,Train "NZ_CCID: Dichlorobis(1,1-dimethylethyl)silane","NZ_CCID: di-tert-butyldichlorosilane",18395-90-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BE5FB3CC-8FA1-4C5D-879D-B3725E8E8C8D,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)(C)[Si](C(C)(C)C)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/87624,PubChem,CC(C)(C)[Si](Cl)(Cl)C(C)(C)C,Train "EU_REACH: 3-hydroxy-2-(hydroxymethyl)-2-methylpropanal",,18516-18-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19735/7/4/2/?documentUUID=fa614022-8234-44a8-9868-a3e403bf9b51,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CO)(CO)C=O,https://pubchem.ncbi.nlm.nih.gov/compound/87688,PubChem,CC(C=O)(CO)CO,Train "EU_REACH: 2-[bis(cyanomethyl)amino]propanenitrile",,185257-07-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2604/7/4/2/?documentUUID=ccdb1309-6fa3-4015-8a92-178c8d6564e7,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C#N)N(CC#N)CC#N,https://pubchem.ncbi.nlm.nih.gov/compound/12040391,PubChem,CC(C#N)N(CC#N)CC#N,Train "EU_REACH: 1,3-Bis(3-methacryloyloxypropyl)-1,1,3,3-tetramethyldisiloxane",,18547-93-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24123/7/4/2/?documentUUID=1183efc3-dff6-4de1-b208-0b34a25af5ee,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OCCC[Si](C)(C)O[Si](C)(C)CCCOC(=O)C(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/87703,PubChem,C=C(C)C(=O)OCCC[Si](C)(C)O[Si](C)(C)CCCOC(=O)C(=C)C,Train "EU_REACH: (3R,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diyl bis(4-hydroxybenzoate)",,185756-31-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21447/7/4/2/?documentUUID=16367ca7-0006-4c25-aecc-9625ec38bee8,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1[C@H]([C@@H]2[C@H](O1)[C@H](CO2)OC(=O)C3=CC=C(C=C3)O)OC(=O)C4=CC=C(C=C4)O,https://pubchem.ncbi.nlm.nih.gov/compound/18664186,PubChem,O=C(O[C@H]1CO[C@H]2[C@@H]1OC[C@H]2OC(=O)c1ccc(O)cc1)c1ccc(O)cc1,Train "EU_REACH: 2-(trifluoromethyl)benzene-1-sulfonamide",,1869-24-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12574/7/4/2/?documentUUID=e3c2e575-15e8-477e-ba38-fd3f97599ae9,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C(=C1)C(F)(F)F)S(=O)(=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/2778018,PubChem,NS(=O)(=O)c1ccccc1C(F)(F)F,Train "EU_REACH: 1,1,1,3,5,5,5-heptamethyltrisiloxane",,1873-88-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15810/7/4/2/?documentUUID=cb577c52-579c-4f34-bfd5-9c75fe36d75e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](O[Si](C)(C)C)O[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6327366,PubChem,C[Si](O[Si](C)(C)C)O[Si](C)(C)C,Train "EU_REACH: 5-[(2-ethylhexyl)oxy]-2-(4-{4-[(2-ethylhexyl)oxy]-2-hydroxyphenyl}-6-(4-methoxyphenyl)-1,3,5-triazin-2-yl)phenol",,187393-00-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12265/7/4/2/?documentUUID=cf8c8081-e7b9-4ef5-9fb1-63f49163a1d3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC1=CC(=C(C=C1)C2=NC(=NC(=N2)C3=CC=C(C=C3)OC)C4=C(C=C(C=C4)OCC(CC)CCCC)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/135487856,PubChem,CCCCC(CC)COc1ccc(-c2nc(-c3ccc(OC)cc3)nc(-c3ccc(OCC(CC)CCCC)cc3O)n2)c(O)c1,Train "EU_REACH: trimethyl(octadecyloxy)silane",,18748-98-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23563/7/4/2/?documentUUID=78329cad-8534-42c7-ad10-e2bfa4427a35,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCCCO[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/87778,PubChem,CCCCCCCCCCCCCCCCCCO[Si](C)(C)C,Train "EU_REACH: dimethyl propylphosphonate",,18755-43-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13875/7/4/2/?documentUUID=e1c6f3d3-b2a6-42fe-9e27-3e411622debc,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCP(=O)(OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/87779,PubChem,CCCP(=O)(OC)OC,Train "EU_REACH: 2-methyl-4-[4-({[4-(prop-2-enoyloxy)butoxy]carbonyl}oxy)benzoyloxy]phenyl 4-({[4-(prop-2-enoyloxy)butoxy]carbonyl}oxy)benzoate",,187585-64-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23898/7/4/2/?documentUUID=51944794-9b43-4fe2-94d5-4e497497d017,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=CC(=C1)OC(=O)C2=CC=C(C=C2)OC(=O)OCCCCOC(=O)C=C)OC(=O)C3=CC=C(C=C3)OC(=O)OCCCCOC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/21351348,PubChem,C=CC(=O)OCCCCOC(=O)Oc1ccc(C(=O)Oc2ccc(OC(=O)c3ccc(OC(=O)OCCCCOC(=O)C=C)cc3)c(C)c2)cc1,Train "EU_REACH: trans,trans-2,3',4',5'-Tetrafluor-4-(4'-propylbicyclohexyl-4 -yl)-biphenyl",,188289-44-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23357/7/4/2/?documentUUID=08eb0082-8954-42d1-bd86-499c14454979,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1CCC(CC1)C2CCC(CC2)C3=CC(=C(C=C3)C4=CC(=C(C(=C4)F)F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/15389837,PubChem,CCCC1CCC(C2CCC(c3ccc(-c4cc(F)c(F)c(F)c4)c(F)c3)CC2)CC1,Train "EU_REACH: 1-acetylazepan-2-one",,1888-91-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25718/7/4/2/?documentUUID=8726885f-a2aa-440e-8593-dbf8b2526923,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)N1CCCCCC1=O,https://pubchem.ncbi.nlm.nih.gov/compound/15904,PubChem,CC(=O)N1CCCCCC1=O,Train "EU_REACH: (2,3-dimethyl-3-phenylbutan-2-yl)benzene",,1889-67-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13835/7/4/2/?documentUUID=4e9615b9-7ea0-464f-b3ab-fadfacb307c5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C1=CC=CC=C1)C(C)(C)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/74681,PubChem,CC(C)(c1ccccc1)C(C)(C)c1ccccc1,Train "EU_REACH: N-(2-(dimethylamino)ethoxy)ethyl)-N-methyl-1,3-propanediamine",,189253-72-3,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5264/7/4/2/?documentUUID=255b8037-a3c5-471e-baa4-9d6116a6a019,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C)CCOCCN(C)CCCN,https://pubchem.ncbi.nlm.nih.gov/compound/18945537,PubChem,CN(C)CCOCCN(C)CCCN,Train "EU_REACH: 4-ethoxy-2,3-difluoro-4'-(trans-4-propylcyclohexyl)-1,1'-biphenyl",,189750-98-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24125/7/4/2/?documentUUID=714e318a-1eb0-4ea3-bf77-20d21dbc1c8d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1CCC(CC1)C2=CC=C(C=C2)C3=C(C(=C(C=C3)OCC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/18681376,PubChem,CCCC1CCC(c2ccc(-c3ccc(OCC)c(F)c3F)cc2)CC1,Train "EU_REACH: methyl (2E)-2-[2-(chloromethyl)phenyl]-2-(methoxyimino)acetate",,189813-45-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/4529/7/4/2/?documentUUID=5819b56c-0567-46dd-8617-5d99228dfd26,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)/C(=N/OC)/C1=CC=CC=C1CCl,https://pubchem.ncbi.nlm.nih.gov/compound/11806789,PubChem,CO/N=C(/C(=O)OC)c1ccccc1CCl,Train "NZ_CCID: Propachlor","NZ_CCID: Acetamide, 2-chloro-N-(1-methylethyl)-N-phenyl-, Acetanilide, 2-chloro-N-isopropyl-, 2-Chloro-N-(1-methylethyl)-N-phenylacetamide",1918-16-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DE3C27B9-F767-4F39-BE02-F7B221FDAE44,"NZ_CCID: Skin Irritation SPECIES: Rabbit RESULT: For technical propachlor (94.5% pure) a slight degree of dermal irritation was observed (2.5/8.0 score) (Braun et al., 1979a); for a 20% formulation of propachlor (again 94.5% pure) there was a slight degree of dermal irritation (1.8/8.0 score) (Braun et al., 1979b); for a 65% formulation a moderate degree of dermal irritation (3.4/8.0 score) (Braun et al., 1979c); and for a 42% formulation corrosive effects were observed (Branch et al., 1982b). REFERENCE SOURCE: [INCHEM EHC 147] Eye Irritation SPECIES: Rabbit RESULT: Severe irritant. REFERENCE SOURCE: [REDS]",,NZ_CCID,1,CC(C)N(C1=CC=CC=C1)C(=O)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/4931,PubChem,CC(C)N(C(=O)CCl)c1ccccc1,Train "EU_REACH: diethyl N-[3-(trimethoxysilyl)propyl]aspartate",,192389-48-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15828/7/4/2/?documentUUID=2861967d-94ab-4b61-ae49-910f0e371add,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C[C@@H](C(=O)OCC)NCCC[Si](OC)(OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/15390519,PubChem,CCOC(=O)C[C@H](NCCC[Si](OC)(OC)OC)C(=O)OCC,Train "JP_CHRIP: 2-Chloro-6-trichloromethylpyridine; Nitrapyrin","JP_CHRIP: 2-Chloro-6-trichloromethylpyridine alpha,alpha,alpha,6-Tetrachloro-2-picoline Nitrapyrin",1929-82-4,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2052e.html,"JP_CHRIP: [Rationale for the Classification] Based on (1), it was classified as ""Not classified."" The category was changed due to new data obtained. [Evidence Data] (1) In a skin irritation test with rabbits according to OECD TG 404 and EPA OPPTS 870.2500, mean scores at 24/48/72 hours were all less than 2.3 (REACH registration dossier (Access on September 2019), EPA Pesticide (2005), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2007)).",Provided,JP_CHRIP,1,Clc1cccc(n1)C(Cl)(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.789B,J-GLOBAL,Clc1cccc(C(Cl)(Cl)Cl)n1,Train "EU_REACH: (2Z)-4-(tert-butylperoxy)-4-oxobut-2-enoic acid",,1931-62-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26777/7/4/2/?documentUUID=64144a65-a429-49e8-91d6-6110dc0665a2,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)OOC(=O)/C=C\C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/5702664,PubChem,CC(C)(C)OOC(=O)/C=C\C(=O)O,Train "EU_REACH: 3-[(2-hydroxyethyl)amino]propan-1-ol",,19344-29-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17126/7/4/2/?documentUUID=47e520e7-623b-4a24-aa7f-482e679fdfdc,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CNCCO)CO,https://pubchem.ncbi.nlm.nih.gov/compound/3015059,PubChem,OCCCNCCO,Train "EU_REACH: 2,2-dimethylthiazolidine",,19351-18-9,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22952/7/4/2/?documentUUID=6aec38e4-a043-4145-928a-25d4f25d3f56,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(NCCS1)C,https://pubchem.ncbi.nlm.nih.gov/compound/88015,PubChem,CC1(C)NCCS1,Train "NZ_CCID: Phenylmethanesulphonyl chloride",,1939-99-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E87D9517-685E-44FF-9405-4F58B89DDB8B,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)CS(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/74740,PubChem,O=S(=O)(Cl)Cc1ccccc1,Train "EU_REACH: 3-amino-p-toluamide",,19406-86-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10821/7/4/2/?documentUUID=5c4aec55-a73b-4378-84cd-332a37c3b4a8,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)C(=O)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/88043,PubChem,Cc1ccc(C(N)=O)cc1N,Train "EU_REACH: 3-amino-4-chlorobenzamide",,19694-10-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10384/7/4/2/?documentUUID=ef08f183-ace8-4471-bf89-91fb8e6c0691,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C=C1C(=O)N)N)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/88200,PubChem,NC(=O)c1ccc(Cl)c(N)c1,Train "EU_REACH: [(1R,2R)-1-methyl-2-{[(1S,3R,5R)-1,2,2-trimethylbicyclo[3.1.0]hexan-3-yl]methyl}cyclopropyl]methanol; [(1S,2S)-1-methyl-2-{[(1S,3R,5R)-1,2,2-trimethylbicyclo[3.1.0]hexan-3-yl]methyl}cyclopropyl]methanol",,198404-98-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29448/7/4/2/?documentUUID=d7ab512a-bdeb-41ce-bb82-bc2ec4b1f1fd,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(C(CC2C1(C2)C)CC3CC3(C)CO)C,https://pubchem.ncbi.nlm.nih.gov/compound/22096564,PubChem,CC1(CO)CC1CC1CC2CC2(C)C1(C)C,Train "EU_REACH: 3-methyl-5-phenylmethoxy-2-(4-phenylmethoxyphenyl)-1H-indole",,198479-63-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17867/7/4/2/?documentUUID=49c5c68c-87aa-4124-ad4b-eee46ab7e768,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(NC2=C1C=C(C=C2)OCC3=CC=CC=C3)C4=CC=C(C=C4)OCC5=CC=CC=C5,https://pubchem.ncbi.nlm.nih.gov/compound/3824745,PubChem,Cc1c(-c2ccc(OCc3ccccc3)cc2)[nH]c2ccc(OCc3ccccc3)cc12,Train "EU_REACH: 1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-5-(benzyloxy)-2(benzyloxyphenyl)-3-methyl-1H-indole",,198480-21-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17891/7/4/2/?documentUUID=78e5c0a5-62eb-4afc-a420-096f882df50e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(N(C2=C1C=C(C=C2)OCC3=CC=CC=C3)CC4=CC=C(C=C4)OCCN5CCCCCC5)C6=CC=C(C=C6)OCC7=CC=CC=C7,https://pubchem.ncbi.nlm.nih.gov/compound/9895831,PubChem,Cc1c(-c2ccc(OCc3ccccc3)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(OCc3ccccc3)cc12,Train "EU_REACH: tert-butyl 2-{(2S,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}-2-[4-(pyridin-2-yl)benzyl]hydrazinecarboxylate",,198904-86-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20798/7/4/2/?documentUUID=79198bff-80b3-492e-9c3a-5fca6013fcdf,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)OC(=O)N[C@@H](CC1=CC=CC=C1)[C@H](CN(CC2=CC=C(C=C2)C3=CC=CC=N3)NC(=O)OC(C)(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/12084688,PubChem,CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2ccccn2)cc1)NC(=O)OC(C)(C)C,Train "EU_REACH: 7-ethoxy-2,2,7-trimethyl-3-(trimethylsilyl)-8-oxa-3-aza-2,7-disiladecane",,201290-01-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20966/7/4/2/?documentUUID=7fb4b700-d447-4d47-9146-29caa7c11c75,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](C)(CCCN([Si](C)(C)C)[Si](C)(C)C)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/87060207,PubChem,CCO[Si](C)(CCCN([Si](C)(C)C)[Si](C)(C)C)OCC,Train "EU_REACH: 2,4,8,10-tetraoxa-3λ⁶,9λ⁶-dithiaspiro[5.5]undecane-3,3,9,9-tetrone",,201419-80-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32238/7/4/2/?documentUUID=ea4db8dd-d0b1-4a81-adda-4f4d04ce450b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C2(COS(=O)(=O)O1)COS(=O)(=O)OC2,https://pubchem.ncbi.nlm.nih.gov/compound/11311505,PubChem,O=S1(=O)OCC2(CO1)COS(=O)(=O)OC2,Train "EU_REACH: 2,6-dichlorobenzyl chloride",,2014-83-7,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23571/7/4/2/?documentUUID=953a3de9-4417-45b2-830f-123688766ecb,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C(=C1)Cl)CCl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/74832,PubChem,ClCc1c(Cl)cccc1Cl,Train "AU_HCIS: 1-Tetradecanamine",,2016-42-4,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4988,,,AU_HCIS,1,CCCCCCCCCCCCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/16217,PubChem,CCCCCCCCCCCCCCN,Train "EU_REACH: flucytosine",,2022-85-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19073/7/4/2/?documentUUID=f7eb1430-03fa-40aa-80a4-80cef4b73a12,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=NC(=O)NC(=C1F)N,https://pubchem.ncbi.nlm.nih.gov/compound/3366,PubChem,Nc1[nH]c(=O)ncc1F,Train "EU_REACH: 2-[(2-hexyldecyl)oxy]benzamide",,202483-62-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1243/7/4/2/?documentUUID=ede46184-ffc3-4a0e-b2ea-b1ad436c78d1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCC(CCCCCC)COC1=CC=CC=C1C(=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/18740353,PubChem,CCCCCCCCC(CCCCCC)COc1ccccc1C(N)=O,Train "EU_REACH: 2-(4-methylpentan-2-yl)aniline",,203448-76-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16251/7/4/2/?documentUUID=e566909c-0c98-4068-892d-4613a4b76193,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CC(C)C1=CC=CC=C1N,https://pubchem.ncbi.nlm.nih.gov/compound/11528441,PubChem,CC(C)CC(C)c1ccccc1N,Train "NZ_CCID: N-(2-Aminoethyl) morpholine",,2038-03-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/96F5C05E-8D55-4786-93A4-31CF2AB2BCEE,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1COCCN1CCN,https://pubchem.ncbi.nlm.nih.gov/compound/408285,PubChem,NCCN1CCOCC1,Train "EU_REACH: Ethyl (3aR,7R,7aR)-2,2-dimethyl-7-[(methylsulfonyl)oxy]-3a,6,7,7a-tetrahydro-1,3-benzodioxole-5-carboxylate",,204254-84-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5355/7/4/2/?documentUUID=bffc91b3-ec82-4e36-9042-a4d074c4deff,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1=CC2C(C(C1)OS(=O)(=O)C)OC(O2)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/23565516,PubChem,CCOC(=O)C1=CC2OC(C)(C)OC2C(OS(C)(=O)=O)C1,Train "EU_REACH: methyl 2-({4-[2-(2-chloro-6-cyano-4-nitrophenyl)diazen-1-yl]-5-acetamido-2-methoxyphenyl}(2-methoxy-2-oxoethyl)amino)propanoate",,204277-61-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/9885/7/4/2/?documentUUID=3c059641-8d9a-4749-98a3-92e171406676,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C(=O)OC)N(CC(=O)OC)C1=C(C=C(C(=C1)NC(=O)C)N=NC2=C(C=C(C=C2Cl)[N+](=O)[O-])C#N)OC,https://pubchem.ncbi.nlm.nih.gov/compound/73555313,PubChem,COC(=O)CN(c1cc(NC(C)=O)c(N=Nc2c(Cl)cc([N+](=O)[O-])cc2C#N)cc1OC)C(C)C(=O)OC,Train "AU_HCIS: 9-Octadecenamide, N-[3-(dimethylamino)propyl]-12-hydroxy-, [R-(Z)]-",,20457-75-4,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6763,,,AU_HCIS,1,CCCCCC[C@H](C/C=C\CCCCCCCC(=O)NCCCN(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/6436523,PubChem,CCCCCC[C@@H](O)C/C=C\CCCCCCCC(=O)NCCCN(C)C,Train "EU_REACH: 2-[4,6-bis({[1,1'-biphenyl]-4-yl})-1,3,5-triazin-2-yl]-5-[(2-ethylhexyl)oxy]phenol",,204583-39-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12741/7/4/2/?documentUUID=5f40fee0-25ac-46a1-8a30-3750d0fc4e48,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC1=CC(=C(C=C1)C2=NC(=NC(=N2)C3=CC=C(C=C3)C4=CC=CC=C4)C5=CC=C(C=C5)C6=CC=CC=C6)O,https://pubchem.ncbi.nlm.nih.gov/compound/135415896,PubChem,CCCCC(CC)COc1ccc(-c2nc(-c3ccc(-c4ccccc4)cc3)nc(-c3ccc(-c4ccccc4)cc3)n2)c(O)c1,Train "AU_HCIS: Ethanedioic acid, dibutyl ester",,2050-60-4,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5155,,,AU_HCIS,1,CCCCOC(=O)C(=O)OCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/16306,PubChem,CCCCOC(=O)C(=O)OCCCC,Train "NZ_CCID: 1-Pentanamine, N-pentyl-","NZ_CCID: Di-n-amylamine, Diamylamine",2050-92-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/463B9978-CC9A-4F54-9E97-52E09F9DEA49,"NZ_CCID: Skin Irritation SPECIES: RESULT: Causes severe eye and skin burns. REFERENCE SOURCE: National Fire Protection Guide. Fire Protection Guide on Hazardous Materials. 10 th ed. Quincy, MA: National Fire Protection Association, 1991.,p. 49-62. **PEER REVIEWED** [HSDB] Eye Irritation SPECIES: Rabbit RESULT: Severe burn. REFERENCE SOURCE: Snyder, R. (ed.). Ethyl Brownings Toxicity and Metabolism of Industrial Solvents. 2nd ed. Volume II: Nitrogen and Phosphorus Solvents. Amsterdam-New York-Oxford: Elsevier, 1990. 40. **PEER REVIEWED** [HSDB]",,NZ_CCID,1,CCCCCNCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/16316,PubChem,CCCCCNCCCCC,Train "NZ_CCID: Hexanoic anhydride",,2051-49-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/15E8EB32-B7E0-44C1-93BA-1F7D29250375,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCC(=O)OC(=O)CCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/74918,PubChem,CCCCCC(=O)OC(=O)CCCCC,Train "NZ_CCID: Dichlorodiphenylmethane",,2051-90-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E4347012-FB60-487B-84A6-A0EE895F0FD0,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)C(C2=CC=CC=C2)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/16327,PubChem,ClC(Cl)(c1ccccc1)c1ccccc1,Train "EU_REACH: 4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl)-N-(2-ethyl-3-oxo-1,2-oxazolidin-4-yl)-2-methylbenzamide",,2061933-85-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33036/7/4/2/?documentUUID=4156cb2c-d4ad-4f86-bc97-b926ababfe1c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN1C(=O)C(CO1)NC(=O)C2=C(C=C(C=C2)C3=NOC(C3)(C4=CC(=C(C(=C4)Cl)F)Cl)C(F)(F)F)C,https://pubchem.ncbi.nlm.nih.gov/compound/87323565,PubChem,CCN1OCC(NC(=O)c2ccc(C3=NOC(c4cc(Cl)c(F)c(Cl)c4)(C(F)(F)F)C3)cc2C)C1=O,Train "NZ_CCID: 1,8-Bis(dimethylamino)-naphthalene",,20734-58-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3242C7F8-AFC8-4DCF-BE8C-CE3655358788,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CN(C)C1=CC=CC2=C1C(=CC=C2)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/88675,PubChem,CN(C)c1cccc2cccc(N(C)C)c12,Train "EU_REACH: (5-ethyl-2,2-dimethyl-1,3-dioxan-5-yl)methanol",,20761-68-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23242/7/4/2/?documentUUID=6a00c7ae-fc53-4902-a268-05fdfbeb5bae,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1(COC(OC1)(C)C)CO,https://pubchem.ncbi.nlm.nih.gov/compound/11816152,PubChem,CCC1(CO)COC(C)(C)OC1,Train "NZ_CCID: Pentanoic anhydride","NZ_CCID: valeric anhydride",2082-59-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8F8B45F8-B32D-4531-A315-7BE8AB9388CD,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCC(=O)OC(=O)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/74959,PubChem,CCCCC(=O)OC(=O)CCCC,Train "JP_CHRIP: n-Octadecyl 3-(4'-hydroxy-3',5'-di-t-butylphenyl) propionate","JP_CHRIP: n-octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propionate n-octadecyl ester 3-(4'-hydroxy-3',5'-di-tert-butylphenyl)propionate Octadecyl 3,5-di-tert-butyl-4-hydroxyhydrocinnamate; Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate",2082-79-3,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0030e.html,"JP_CHRIP: It is described that in a skin irritation study (OECD TG 404) using rabbits exposed to an undiluted solution of this substance for 24 hours, no irritation was observed (SIDS (2006)). Therefore, this substance was classified as ""Not classified"" based on the description that this substance is not regarded as a skin irritant (SIDS (2006)).",Provided,JP_CHRIP,1,CCCCCCCCCCCCCCCCCCOC(=O)CCc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J21.231H,J-GLOBAL,CCCCCCCCCCCCCCCCCCOC(=O)CCc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1,Train "EU_REACH: 5-butoxy-2-[4-(4-butoxy-2-hydroxyphenyl)-6-(2,4-dibutoxyphenyl)-1,3,5-triazin-2-yl]phenol",,208343-47-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30662/7/4/2/?documentUUID=ca06e6d9-03f0-4bed-b7f5-2997854dc2c3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOC1=CC(=C(C=C1)C2=NC(=NC(=N2)C3=C(C=C(C=C3)OCCCC)OCCCC)C4=C(C=C(C=C4)OCCCC)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/135431040,PubChem,CCCCOc1ccc(-c2nc(-c3ccc(OCCCC)cc3O)nc(-c3ccc(OCCCC)cc3OCCCC)n2)c(O)c1,Train "NZ_CCID: Dimethylaminotrimethylsilane","NZ_CCID: N,N-dimethyltrimethylsilylamine",2083-91-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6D42137E-6E23-4DFE-925C-BC45A5779053,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CN(C)[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/74965,PubChem,CN(C)[Si](C)(C)C,Train "NZ_CCID: 2-(Hydroxymethyl)-N-methylpiperidine","NZ_CCID: 1-methyl-2-piperidinemethanol",20845-34-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D34626DC-88BC-4774-A785-BDB193003F24,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CN1CCCCC1CO,https://pubchem.ncbi.nlm.nih.gov/compound/89394,PubChem,CN1CCCCC1CO,Train "EU_REACH: 1-butoxy-2,3-difluoro-4-[(1s,4r)-4-propylcyclohexyl]benzene",,208709-55-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21891/7/4/2/?documentUUID=b0549549-1480-44a3-b99f-b578b7f3441b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOC1=C(C(=C(C=C1)C2CCC(CC2)CCC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/22184028,PubChem,CCCCOc1ccc(C2CCC(CCC)CC2)c(F)c1F,Train "EU_REACH: 2-(2,4,5-trifluorophenyl)acetic acid",,209995-38-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33530/7/4/2/?documentUUID=2dd0c89a-0dcd-449a-af8e-3849f26e6852,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(C(=CC(=C1F)F)F)CC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/2777950,PubChem,O=C(O)Cc1cc(F)c(F)cc1F,Train "JP_CHRIP: (E)-1-(2-Chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine; Clothianidin",,210880-92-5,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0027e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 6) (OECD TG 404, GLP, 4-hour application, 72-hour observation), no skin irritation was seen (erythema/eschar score: 0/0/0/0/0/0, edema score: 0/0/0/0/0/0) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014), JMPR (2010), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2015)).",Provided,JP_CHRIP,1,CNC(=N[N+](=O)[O-])NCc1cnc(Cl)s1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.082.227K,J-GLOBAL,CNC(=N[N+](=O)[O-])NCc1cnc(Cl)s1,Train "EU_REACH: 3-(triethoxysilyl)propyl 2-methylprop-2-enoate",,21142-29-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25613/7/4/2/?documentUUID=ce14ffe0-9dfa-4556-94b1-8a7a4cb14b79,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](CCCOC(=O)C(=C)C)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/88798,PubChem,C=C(C)C(=O)OCCC[Si](OCC)(OCC)OCC,Train "EU_REACH: 1-(2-ethylbutyl)cyclohexanecarbonyl chloride",,211515-46-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22233/7/4/2/?documentUUID=c63c2c5c-65fa-4b07-9f14-6d24bd33e111,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(CC)CC1(CCCCC1)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/10657125,PubChem,CCC(CC)CC1(C(=O)Cl)CCCCC1,Train "EU_REACH: 1,1,5,5,5-hexamethyl-3-phenyl-3-[(trimethylsilyl)oxy]trisiloxane",,2116-84-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22255/7/4/2/?documentUUID=6462f52c-eb1e-4672-ba6c-225bf2d324d1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](C)(C)O[Si](C1=CC=CC=C1)(O[Si](C)(C)C)O[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/62427,PubChem,C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)c1ccccc1,Train "EU_REACH: 2-hydroxy-N-((2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl)octadecanamide",,212070-45-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30008/7/4/2/?documentUUID=802f2d95-c389-4f91-8842-8f72c9e3434c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCC(C(=O)N[C@@H](CO)[C@@H]([C@@H](CCCCCCCCCCCCCC)O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/44625889,PubChem,CCCCCCCCCCCCCCCCC(O)C(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC,Train "EU_REACH: 4,6-Dichloro-5-fluoropyrimidine",,213265-83-9,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33824/7/4/2/?documentUUID=a59bacb8-5c03-46d9-a9d3-350b738a4d85,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=NC(=C(C(=N1)Cl)F)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/11286675,PubChem,Fc1c(Cl)ncnc1Cl,Train "EU_REACH: 4-(naphthalen-2-yl)-1,3-thiazol-2-amine",,21331-43-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26580/7/4/2/?documentUUID=3f2eeeb8-d51b-4cca-9f29-a99125d90f6e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C=C(C=CC2=C1)C3=CSC(=N3)N,https://pubchem.ncbi.nlm.nih.gov/compound/673702,PubChem,Nc1nc(-c2ccc3ccccc3c2)cs1,Train "EU_REACH: 3-hydroxy-N'-(4-methylpentan-2-ylidene)naphthalene-2-carbohydrazide",,214417-91-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32159/7/4/2/?documentUUID=9317eef4-7dad-426e-998e-5f7eba95c8fe,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C/C(=N\NC(=O)C1=CC2=CC=CC=C2C=C1O)/C,https://pubchem.ncbi.nlm.nih.gov/compound/5779530,PubChem,C/C(CC(C)C)=N/NC(=O)c1cc2ccccc2cc1O,Train "EU_REACH: ethenyl dodecanoate",,2146-71-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1546/7/4/2/?documentUUID=b089207e-b8eb-4e3c-8384-f20e20d0feda,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCC(=O)OC=C,https://pubchem.ncbi.nlm.nih.gov/compound/75069,PubChem,C=COC(=O)CCCCCCCCCCC,Train "EU_REACH: 2,20-dichloro-13,31-diethyl-4,22-dioxa-13,18,31,36-tetraazanonacyclo[19.15.0.0³,¹⁹.0⁵,¹⁷.0⁶,¹⁴.0⁷,¹².0²³,³⁵.0²⁴,³².0²⁵,³⁰]hexatriaconta-1(36),2,5,7(12),8,10,14,16,18,20,23(35),24(32),25,27,29,33-hexadecaene",,215247-95-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18047/7/4/2/?documentUUID=01c5813b-03b1-460a-9d6b-5fac4420fc3c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN1C2=C(C3=CC=CC=C31)C4=C(C=C2)N=C5C(=C(C6=NC7=C(C8=C(C=C7)N(C9=CC=CC=C98)CC)OC6=C5Cl)Cl)O4,https://pubchem.ncbi.nlm.nih.gov/compound/11845128,PubChem,CCn1c2ccccc2c2c3c(ccc21)N=c1c(Cl)c2c(c(Cl)c1O3)=Nc1ccc3c(c1O2)c1ccccc1n3CC,Train "AU_HCIS: 1-Docosanamine, N,N-dimethyl-",,21542-96-1,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5007,,,AU_HCIS,1,CCCCCCCCCCCCCCCCCCCCCCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/88942,PubChem,CCCCCCCCCCCCCCCCCCCCCCN(C)C,Train "EU_REACH: 3,​3,​5,​7,​7-​pentamethyl-1,2,4-trioxepane",,215877-64-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/3940/7/4/2/?documentUUID=9fc0c6b9-221f-49dc-b8c3-95212fd40b73,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1CC(OOC(O1)(C)C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/11019359,PubChem,CC1CC(C)(C)OOC(C)(C)O1,Train "NZ_CCID: t-Butyldiethanolamine",,2160-93-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/947540D4-3595-4257-A95E-4868D4EED875,"NZ_CCID: Skin Irritation R-PHRASE: R 34. [Chemwatch] Eye Irritation R-PHRASE: R 34/ 41. [Chemwatch]",,NZ_CCID,1,CC(C)(C)N(CCO)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/62430,PubChem,CC(C)(C)N(CCO)CCO,Train "NZ_CCID: 2-Methoxybenzoyl chloride","NZ_CCID: o-anisoyl chloride",21615-34-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EE70EB9C-E609-4510-8733-1EC1A3FED432,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,COC1=CC=CC=C1C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/88969,PubChem,COc1ccccc1C(=O)Cl,Train "EU_REACH: N,N'-bis[2,6-bis(propan-2-yl)phenyl]methanediimine",,2162-74-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13695/7/4/2/?documentUUID=2c9cfe0f-29cb-4ba3-a9f4-f6b07cde159c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C1=C(C(=CC=C1)C(C)C)N=C=NC2=C(C=CC=C2C(C)C)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/75100,PubChem,CC(C)c1cccc(C(C)C)c1N=C=Nc1c(C(C)C)cccc1C(C)C,Train "JP_CHRIP: 3-Cyclohexyl-5,6-trimethyleneuracil; Lenacil",,2164-08-1,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-0008e.html,"JP_CHRIP: [Rationale for the Classification] Based on (1) and (2), it was classified as ""Not classified."" [Evidence Data] (1) In a skin irritation test (equivalent to OECD TG 404, GLP) with rabbits (n=3, female), since both mean scores of erythema and edema were 0 at 24/48/72 hours, it was judged to be non-irritating to the skin (CLH Report (2013)). (2) This substance is not irritating to the skin (PATTY (6th, 2012)).",Provided,JP_CHRIP,1,O=c1[nH]c2CCCc2c(=O)n1C1CCCCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.387A,J-GLOBAL,O=c1[nH]c2c(c(=O)n1C1CCCCC1)CCC2,Train "EU_REACH: 2-[2-oxo-5-(2,4,4-trimethylpentan-2-yl)-2,3-dihydro-1-benzofuran-3-yl]-4-(2,4,4-trimethylpentan-2-yl)phenyl acetate",,216698-07-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6619/7/4/2/?documentUUID=c6d774d3-0dfa-451d-a287-ce84e39797cd,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)OC1=C(C=C(C=C1)C(C)(C)CC(C)(C)C)C2C3=C(C=CC(=C3)C(C)(C)CC(C)(C)C)OC2=O,https://pubchem.ncbi.nlm.nih.gov/compound/154218,PubChem,CC(=O)Oc1ccc(C(C)(C)CC(C)(C)C)cc1C1C(=O)Oc2ccc(C(C)(C)CC(C)(C)C)cc21,Train "EU_REACH: 2,2-bis(tert-butylperoxy)butane",,2167-23-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22574/7/4/2/?documentUUID=40188a88-67cc-44b6-9147-0b45cb8da0ca,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C)(OOC(C)(C)C)OOC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/221260,PubChem,CCC(C)(OOC(C)(C)C)OOC(C)(C)C,Train "EU_REACH: phenyl 2-methylprop-2-enoate",,2177-70-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17121/7/4/2/?documentUUID=b7a9a25a-72a8-422c-ae93-67f0ffaf9797,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OC1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/75121,PubChem,C=C(C)C(=O)Oc1ccccc1,Train "EU_REACH: 3-((C9-11-iso,C10-rich)alkyloxy)propan-1-amine",,218141-16-3,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12430/7/4/2/?documentUUID=4e6088ca-b703-4181-85fc-a9c3249544a8,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCCCOCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/120013,PubChem,CC(C)CCCCCCCOCCCN,Train "EU_REACH: 1,1'-propane-2,2-diylbis[3,5-dibromo-4-(2,3-dibromopropoxy)benzene]",,21850-44-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13876/7/4/2/?documentUUID=fac33602-52dc-4686-8415-d3f9989ff39e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C1=CC(=C(C(=C1)Br)OCC(CBr)Br)Br)C2=CC(=C(C(=C2)Br)OCC(CBr)Br)Br,https://pubchem.ncbi.nlm.nih.gov/compound/62753,PubChem,CC(C)(c1cc(Br)c(OCC(Br)CBr)c(Br)c1)c1cc(Br)c(OCC(Br)CBr)c(Br)c1,Train "EU_REACH: (1r,4r)-4-tert-butylcyclohexan-1-ol",,21862-63-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10189/7/4/2/?documentUUID=f1d78275-c1aa-4689-b69d-9ee223eee158,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1CCC(CC1)O,https://pubchem.ncbi.nlm.nih.gov/compound/7391,PubChem,CC(C)(C)C1CCC(O)CC1,Train "EU_REACH: 1-{[3-(triethoxysilyl)propyl]sulfanyl}octan-1-one",,220727-26-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17060/7/4/2/?documentUUID=3dbbb484-738b-45d5-89c0-d369e762126c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCC(=O)SCCC[Si](OCC)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/12135713,PubChem,CCCCCCCC(=O)SCCC[Si](OCC)(OCC)OCC,Train "EU_REACH: 2,2'-[(2,2',5,5'-tetrachlorobiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis[N-(2,4-dimethylphenyl)-3-oxobutanamide]",,22094-93-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2023/7/4/2/?documentUUID=5bcaa16e-70fa-4f9a-99bb-4c89e7486457,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)NC(=O)C(C(=O)C)N=NC2=C(C=C(C(=C2)Cl)C3=CC(=C(C=C3Cl)N=NC(C(=O)C)C(=O)NC4=C(C=C(C=C4)C)C)Cl)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/89597,PubChem,CC(=O)C(N=Nc1cc(Cl)c(-c2cc(Cl)c(N=NC(C(C)=O)C(=O)Nc3ccc(C)cc3C)cc2Cl)cc1Cl)C(=O)Nc1ccc(C)cc1C,Train "EU_REACH: oxirane",,2210-79-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14553/7/4/2/?documentUUID=cc9d19cc-c0a6-421c-a7e4-ade45e36dbdc,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=CC=C1OCC2CO2,https://pubchem.ncbi.nlm.nih.gov/compound/16640,PubChem,Cc1ccccc1OCC1CO1,Train "NZ_CCID: 2-(Bromomethyl)-benzonitrile",,22115-41-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E43BBD58-9746-430F-980E-8C24A96EC1AC,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)CBr)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/89599,PubChem,N#Cc1ccccc1CBr,Train "EU_REACH: (2-chloro-1,1-diethoxyethyl)silane",,2212-10-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/28089/7/4/2/?documentUUID=630601cb-2d5c-4495-80f0-43579cf0e1e6,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](C)(CCl)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/16650,PubChem,CCO[Si](C)(CCl)OCC,Train "EU_REACH: N-cyclopropyl-4-[(2-methoxybenzoyl)sulfamoyl]benzamide",,221667-31-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1169/7/4/2/?documentUUID=ea104b4d-7687-412c-b07c-025ce5a29854,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC=CC=C1C(=O)NS(=O)(=O)C2=CC=C(C=C2)C(=O)NC3CC3,https://pubchem.ncbi.nlm.nih.gov/compound/11707647,PubChem,COc1ccccc1C(=O)NS(=O)(=O)c1ccc(C(=O)NC2CC2)cc1,Train "EU_REACH: 3,3'-[methylenebis(oxymethylene)]diheptane",,22174-70-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11718/7/4/2/?documentUUID=f0974541-11af-40a6-9077-7ddca1adcfd1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COCOCC(CC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/89612,PubChem,CCCCC(CC)COCOCC(CC)CCCC,Train "EU_REACH: endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate",,22235-81-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6852/7/4/2/?documentUUID=ed80495f-2664-4875-a566-f8553080019b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)N1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/20625249,PubChem,CC(C)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2,Train "EU_REACH: 1-(2,4-dichlorophenyl)ethan-1-one",,2234-16-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5283/7/4/2/?documentUUID=44e36bc1-55ee-418c-bf87-51f763d5efe4,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C1=C(C=C(C=C1)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/16693,PubChem,CC(=O)c1ccc(Cl)cc1Cl,Train "JP_CHRIP: 3,4-Dichloro-N-(2-cyanophenyl)isothiazole-5-carboxamide; Isotianil",,224049-04-1,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0043e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 72-hour observation), no irritation changes were seen (erythema/eschar score: 0/0/0, edema score: 0/0/0) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009), REACH registration dossier (Accessed Sep. 2020), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)).",Provided,JP_CHRIP,1,Clc1nsc(C(=O)Nc2ccccc2C#N)c1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.510.822A,J-GLOBAL,N#Cc1ccccc1NC(=O)c1snc(Cl)c1Cl,Train "JP_CHRIP: 1,5-Diaminonaphthalene","JP_CHRIP: 1,5-Diaminonaphthalene 1,5-Naphthalenediamine 1,5-Naphthylenediamine",2243-62-1,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0162e.html,"JP_CHRIP: On the basis that a semi-occlusive test (OECD TG 404) applied 500 mg test substance to rabbit skin for 4 hours resulted in irritation scores of 0 in all animals at all observation points and no primary irritant effects (BUA Report 115 (1995)), it was classified as ""Not classified.""",Provided,JP_CHRIP,1,Nc1cccc2c(N)cccc12,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J40.472A,J-GLOBAL,Nc1cccc2c(N)cccc12,Train "NZ_CCID: 2-Naphthoyl chloride",,2243-83-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/92F6303F-FC38-4399-BEBA-B45E831F2309,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C2C=C(C=CC2=C1)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/75246,PubChem,O=C(Cl)c1ccc2ccccc2c1,Train "EU_REACH: 4-(butan-2-yloxy)-3,5-dimethoxybenzaldehyde",,224586-49-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30811/7/4/2/?documentUUID=79976e59-e65a-445d-a3b6-a191f86a5c5a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C)OC1=C(C=C(C=C1OC)C=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/23110023,PubChem,CCC(C)Oc1c(OC)cc(C=O)cc1OC,Train "EU_REACH: 2-{2-ethoxy-5-[(4-ethylpiperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one",,224785-90-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6882/7/4/2/?documentUUID=dea19b55-a44c-4782-a77d-f928d26b2131,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1=NC(=C2N1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CC)OCC)C,https://pubchem.ncbi.nlm.nih.gov/compound/135400189,PubChem,CCCc1nc(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)nn12,Train "EU_REACH: 2-[(3-sulfanylpropanoyl)oxy]ethyl 3-sulfanylpropanoate",,22504-50-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26261/7/4/2/?documentUUID=efb35323-721e-429f-8666-1fcdb9bb9aff,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CS)C(=O)OCCOC(=O)CCS,https://pubchem.ncbi.nlm.nih.gov/compound/89735,PubChem,O=C(CCS)OCCOC(=O)CCS,Train "EU_REACH: 6-chloro-1,3-benzoxazole",,227197-72-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11364/7/4/2/?documentUUID=971c7857-cfdf-4d77-a677-abec60100a85,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC2=C(C=C1Cl)OC=N2,https://pubchem.ncbi.nlm.nih.gov/compound/9350362,PubChem,Clc1ccc2ncoc2c1,Train "NZ_CCID: 6-Bromohexanoyl chloride","NZ_CCID: 6-bromocaproyl chloride",22809-37-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/49143CBD-78C4-495B-A00F-443A4A04A367,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(CCC(=O)Cl)CCBr,https://pubchem.ncbi.nlm.nih.gov/compound/89848,PubChem,O=C(Cl)CCCCCBr,Train "EU_REACH: propan-2-yl 2-(N-methyldodecanamido)acetate",,230309-38-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27893/7/4/2/?documentUUID=ab2f80da-094a-404c-b090-3364127aa324,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCC(=O)N(C)CC(=O)OC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/9926846,PubChem,CCCCCCCCCCCC(=O)N(C)CC(=O)OC(C)C,Train "EU_REACH: 2,2,2-trifluoro-1-{5,8,14-triazatetracyclo[10.3.1.0²,¹¹.0⁴,⁹]hexadeca-2,4,6,8,10-pentaen-14-yl}ethan-1-one",,230615-70-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21699/7/4/2/?documentUUID=ceb47fba-3fc1-4856-b331-7cc8f0c2e658,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C2CN(CC1C3=CC4=NC=CN=C4C=C23)C(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/11483621,PubChem,O=C(N1CC2CC(C1)c1cc3nccnc3cc12)C(F)(F)F,Train "EU_REACH: 6-methyl-2-(4-methylcyclohex-3-en-1-yl)hept-5-en-2-ol",,23089-26-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23596/7/4/2/?documentUUID=eed7fe6e-d390-4569-8b9c-93190b918921,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC[C@H](CC1)[C@](C)(CCC=C(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/442343,PubChem,CC(C)=CCC[C@](C)(O)[C@@H]1CC=C(C)CC1,Train "EU_REACH: 2-ethyl-2-{[2-ethyl-3-hydroxy-2-(hydroxymethyl)propoxy]methyl}propane-1,3-diol",,23235-61-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1913/7/4/2/?documentUUID=824a0efc-a53e-46d3-b7db-2e7cdf656a49,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(CO)(CO)COCC(CC)(CO)CO,https://pubchem.ncbi.nlm.nih.gov/compound/90038,PubChem,CCC(CO)(CO)COCC(CC)(CO)CO,Train "EU_REACH: 2-[2-(carboxymethoxy)ethoxy]acetic acid",,23243-68-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22578/7/4/2/?documentUUID=b0278698-75d7-4f15-81c6-a39c3805aa47,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(COCC(=O)O)OCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/90039,PubChem,O=C(O)COCCOCC(=O)O,Train "NZ_CCID: 6-Chloro-3,4-methylenedioxybenzyl chloride","NZ_CCID: 6-chloropiperonyl chloride",23468-31-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/714839FB-64AA-4BA5-8CE6-3F322629C556,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1OC2=C(O1)C=C(C(=C2)CCl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/90113,PubChem,ClCc1cc2c(cc1Cl)OCO2,Train "EU_REACH: 3,3'-[(9,10-dioxo-9,10-dihydroanthracene-1,4-diyl)diimino]bis(N-cyclohexyl-2,4,6-trimethylbenzenesulfonamide)",,23552-74-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18069/7/4/2/?documentUUID=0dbc00e3-e68b-488f-93ed-e67fca9a3ac4,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C(=C1NC2=C3C(=C(C=C2)NC4=C(C(=C(C=C4C)C)S(=O)(=O)NC5CCCCC5)C)C(=O)C6=CC=CC=C6C3=O)C)S(=O)(=O)NC7CCCCC7)C,https://pubchem.ncbi.nlm.nih.gov/compound/90157,PubChem,Cc1cc(C)c(S(=O)(=O)NC2CCCCC2)c(C)c1Nc1ccc(Nc2c(C)cc(C)c(S(=O)(=O)NC3CCCCC3)c2C)c2c1C(=O)c1ccccc1C2=O,Train "JP_CHRIP: Dimethyl 4,4'-(o-phenylene)bis(3-thioallophanate) (synonym: Thiophanate-methyl)","JP_CHRIP: Thiophanate methyl Thiophanate-methyl",23564-05-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2017.html,"JP_CHRIP: 【分類根拠】 （１）、（２）より、区分に該当しない。 【根拠データ】 （１）ウサギ（n=6）を用いた皮膚刺激性試験（OECD TG 404相当、GLP、閉塞、4時間適用、72時間観察）において、全例で皮膚刺激性反応はみられなかった（紅斑・痂皮スコア：0/0/0/0/0/0、浮腫スコア：0/0/0/0/0/0）との報告がある（ECHA RAC Opinion (2019)、CLH Report (2018)、REACH登録情報 (Accessed Aug. 2021)）。 （２）本物質は皮膚刺激性物質ではない（EFSA (2018)、JMPR (2017)、EPA Pesticides (2005)）。",Provided,JP_CHRIP,1,COC(=O)NC(=S)Nc1ccccc1NC(=S)NC(=O)OC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.471A,J-GLOBAL,COC(=O)NC(=S)Nc1ccccc1NC(=S)NC(=O)OC,Train "EU_REACH: 2-{1-oxa-4-azaspiro[4.5]decan-4-yl}ethan-1-ol",,2359-11-7,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16434/7/4/2/?documentUUID=89c647ce-cbbc-4f0d-92f3-36a986d7c4a5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CCC2(CC1)N(CCO2)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/75380,PubChem,OCCN1CCOC12CCCCC2,Train "EU_REACH: 2,4,6,8-tetramethyl-1,3,5,7,2,4,6,8-tetroxatetrasilocane",,2370-88-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15844/7/4/2/?documentUUID=1bf574cd-9386-45d7-9a64-b5f82d51a10c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si]1O[Si](O[Si](O[Si](O1)C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6327421,PubChem,C[Si]1O[Si](C)O[Si](C)O[Si](C)O1,Train "EU_REACH: bis(3-aminopropyl)(dodecyl)amine KR_NCIS: N1-(3-Aminopropyl)-N1-dodecyl-1,3-propanediamine NZ_CCID: 1,3-Propanediamine, N-(3-aminopropyl)-N-dodecyl-",,2372-82-9,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5949/7/4/2/?documentUUID=6ea236a2-6c54-42f6-af1b-e60f792b049a KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D2A24768-7738-4823-BADF-4B2AAAA2B955","EU_REACH: Experimental study (OECD TG 404, GLP) NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",Provided,"EU_REACH, KR_NCIS, NZ_CCID",3,CCCCCCCCCCCCN(CCCN)CCCN,https://pubchem.ncbi.nlm.nih.gov/compound/75407,PubChem,CCCCCCCCCCCCN(CCCN)CCCN,Train "EU_REACH: 2,4,6-trimethyl-2,4,6-tris(3,3,3-trifluoropropyl)cyclotrisiloxane",,2374-14-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13466/7/4/2/?documentUUID=64f04cc9-ac0b-4b85-88bc-aa84648e171c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si]1(O[Si](O[Si](O1)(C)CCC(F)(F)F)(C)CCC(F)(F)F)CCC(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/75410,PubChem,C[Si]1(CCC(F)(F)F)O[Si](C)(CCC(F)(F)F)O[Si](C)(CCC(F)(F)F)O1,Train "EU_REACH: 2-benzoyl-5-[3-(4-benzoyl-3-hydroxyphenoxy)-2-hydroxypropoxy]phenol",,23911-85-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13490/7/4/2/?documentUUID=cff04efc-ac6d-476d-bd07-3c3a37ef09cb,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C(=O)C2=C(C=C(C=C2)OCC(COC3=CC(=C(C=C3)C(=O)C4=CC=CC=C4)O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/1242235,PubChem,O=C(c1ccccc1)c1ccc(OCC(O)COc2ccc(C(=O)c3ccccc3)c(O)c2)cc1O,Train "EU_REACH: ethyl (2S,3R)-2-amino-3-hydroxybutanoate",,23926-51-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31918/7/4/2/?documentUUID=023e38db-ba21-4116-80a7-027e3bbb6365,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)[C@H]([C@@H](C)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/2763097,PubChem,CCOC(=O)[C@@H](N)[C@@H](C)O,Train "NZ_CCID: 4-Methoxybenzylamine",,2393-23-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EC35F88A-8B6A-4F39-9F7F-CA2763E98208,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,COC1=CC=C(C=C1)CN,https://pubchem.ncbi.nlm.nih.gov/compound/75452,PubChem,COc1ccc(CN)cc1,Train "EU_REACH: tetrahydrofuran-2-ylmethyl acrylate",,2399-48-6,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20149/7/4/2/?documentUUID=4075575d-14d7-494a-b943-18bbfa6d710f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CC(=O)OCC1CCCO1,https://pubchem.ncbi.nlm.nih.gov/compound/94232,PubChem,C=CC(=O)OCC1CCCO1,Train "EU_REACH: 2,2,6,6-tetramethylpiperidin-4-ol JP_CHRIP: 2,2,6,6-Tetramethylpiperidin-4-ol NZ_CCID: 2,2,6,6-Tetramethyl-4-piperidinol","JP_CHRIP: 2,2,6,6-tetramethylpiperidin-4-ol 2,2,6,6-tetramethylpiperidin-4-ol (synonym:2,2,6,6-tetramethyl-4-hydroxypiperidine) 4-hydroxy-2,2,6,6-tetramethylpiperidine 4-Piperidinol, 2,2,6,6-tetramethyl-",2403-88-5,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14709/7/4/2/?documentUUID=720157c5-76b2-4d73-9cd9-e14dce021d2c JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-0050e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DCEB6C1B-B5BF-471D-8012-26274E02EDA0","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: It was classified in Category 1 because it is described that a skin irritation test with rabbits (OECD TG 404) resulted in severe irritation (SIDS (2003)), and one of the animals did not recover even after 14 days (SIDS (2003)). NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",Provided,"EU_REACH, JP_CHRIP, NZ_CCID",3,CC1(C)CC(O)CC(C)(C)N1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J39.108E,J-GLOBAL,CC1(C)CC(O)CC(C)(C)N1,Train "EU_REACH: 5-chlorothiophene-2-carboxylic acid",,24065-33-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23889/7/4/2/?documentUUID=33965c7d-da5b-4f0c-9977-99c8b79439a0,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(SC(=C1)Cl)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/95048,PubChem,O=C(O)c1ccc(Cl)s1,Train "EU_REACH: 7-methyl-3,4-dihydro-2H-1,3-benzoxazine-2,4-dione",,24088-77-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10884/7/4/2/?documentUUID=fe35ee98-60e0-4d2f-ab85-54db84097352,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC2=C(C=C1)C(=O)NC(=O)O2,https://pubchem.ncbi.nlm.nih.gov/compound/11550082,PubChem,Cc1ccc2c(=O)[nH]c(=O)oc2c1,Train "EU_REACH: 6-methyloct-5-en-2-one",,24199-46-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12003/7/4/2/?documentUUID=32ab691d-e726-4035-9207-66ed86823bfe,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC/C(=C/CCC(=O)C)/C,https://pubchem.ncbi.nlm.nih.gov/compound/5363290,PubChem,CC/C(C)=C/CCC(C)=O,Train "EU_REACH: 2-hexyldecan-1-ol",,2425-77-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5585/7/4/2/?documentUUID=99c7899a-ae82-48ec-8a51-4917a873ab5b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCC(CCCCCC)CO,https://pubchem.ncbi.nlm.nih.gov/compound/95337,PubChem,CCCCCCCCC(CO)CCCCCC,Train "NZ_CCID: 1,2,7,8-Diepoxyoctane",,2426-07-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F6FF0B9A-0B36-4B65-BD57-477D5BDD4F1B,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1C(O1)CCCCC2CO2,https://pubchem.ncbi.nlm.nih.gov/compound/17048,PubChem,C(CCC1CO1)CC1CO1,Train "EU_REACH: 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid",,24280-93-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15977/7/4/2/?documentUUID=9cc5ab29-6b54-4594-ba05-d021f4f26fd7,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C2COC(=O)C2=C(C(=C1OC)C/C=C(\C)/CCC(=O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/446541,PubChem,COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)O)C(=O)OC2,Train "EU_REACH: 1,3-dimethoxy-1,3-dihydro-2-benzofuran",,24388-70-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24867/7/4/2/?documentUUID=cf9d737d-808c-43c0-8b68-969311731a4d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1C2=CC=CC=C2C(O1)OC,https://pubchem.ncbi.nlm.nih.gov/compound/11629690,PubChem,COC1OC(OC)c2ccccc21,Train "JP_CHRIP: 2-(Dimethylamino)ethyl acrylate","JP_CHRIP: dimethylamino ethyl acrylate Dimethylaminoethyl acrylate; 2-Propenoic acid, 2-(dimethylamino)ethyl ester",2439-35-2,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-2017e.html,"JP_CHRIP: In a test in which 0.5 mL of the undiluted test substance was applied to six rabbits for 4 hours (OECD TG 404), corrosivity was seen in all the animals, and the primary dermal irritation index (PDII) was 8 (SIDS (2003)). Therefore, it was classified in Category 1. Besides, other than the above, results of two Draize tests with rabbits were reported, PII was 8 and 7.6, and it was assessed as corrosive in both (SIDS (2003)).",Provided,JP_CHRIP,1,CN(C)CCOC(=O)C=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J38.142J,J-GLOBAL,C=CC(=O)OCCN(C)C,Train "EU_REACH: 2,6-diethyl-2,3,6-trimethyl-1-(1-phenylethoxy)piperidin-4-one",,244021-01-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17025/7/4/2/?documentUUID=ee396b4c-82e9-48e4-bfa4-1467b89cdfd0,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1(CC(=O)C(C(N1OC(C)C2=CC=CC=C2)(C)CC)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/22341848,PubChem,CCC1(C)CC(=O)C(C)C(C)(CC)N1OC(C)c1ccccc1,Train "EU_REACH: 2-hexadecanamidoacetic acid",,2441-41-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21392/7/4/2/?documentUUID=419ebf10-9572-4785-8ce4-1134ed908e0e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCC(=O)NCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/151008,PubChem,CCCCCCCCCCCCCCCC(=O)NCC(=O)O,Train "EU_REACH: 2-Methyl-3-methoxy benzoyl chloride",,24487-91-0,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/28358/7/4/2/?documentUUID=0a0590d9-a6e3-4429-87fa-594e250ff664,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=CC=C1OC)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/14719554,PubChem,COc1cccc(C(=O)Cl)c1C,Train "EU_REACH: 2,6-bis(propan-2-yl)aniline",,24544-04-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10001/7/4/2/?documentUUID=a32ab69e-3794-402c-a9d0-53e19bb3950a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C1=C(C(=CC=C1)C(C)C)N,https://pubchem.ncbi.nlm.nih.gov/compound/32484,PubChem,CC(C)c1cccc(C(C)C)c1N,Train "EU_REACH: 2,6-diethyl-4-methylaniline",,24544-08-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10873/7/4/2/?documentUUID=b2d60ef5-18d1-486e-8449-998969542de1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1=CC(=CC(=C1N)CC)C,https://pubchem.ncbi.nlm.nih.gov/compound/90536,PubChem,CCc1cc(C)cc(CC)c1N,Train "EU_REACH: 2-ethyl-6-methylaniline",,24549-06-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12644/7/4/2/?documentUUID=8689db96-ca10-42cd-9e11-70da7bf74ab8,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1=CC=CC(=C1N)C,https://pubchem.ncbi.nlm.nih.gov/compound/32485,PubChem,CCc1cccc(C)c1N,Train "NZ_CCID: 4-(1-Pyrrolidinyl) pyridine","NZ_CCID: 4-pyrrolidinopyridine",2456-81-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/62EDDD3C-3D58-40B5-B2BD-31EB7EB5FB7C,"NZ_CCID: Skin Irritation UN CLASS: 8; Packing Group II. Eye Irritation R PHRASE: R 35 [Company Data]",,NZ_CCID,1,C1CCN(C1)C2=CC=NC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/75567,PubChem,c1cc(N2CCCC2)ccn1,Train "EU_REACH: 2-[[4-[(2-cyanoethyl)(2-phenylethyl)amino]phenyl]azo]-5-nitrobenzonitrile",,24610-00-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24978/7/4/2/?documentUUID=3d9995c1-1304-4d79-b30d-c5d909e5c228,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)CCN(CCC#N)C2=CC=C(C=C2)N=NC3=C(C=C(C=C3)[N+](=O)[O-])C#N,https://pubchem.ncbi.nlm.nih.gov/compound/90555,PubChem,N#CCCN(CCc1ccccc1)c1ccc(N=Nc2ccc([N+](=O)[O-])cc2C#N)cc1,Train "KR_NCIS: 3-(Chlorodimethylsilyl)propyl 2-methyl-2-propenoate",,24636-31-5,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CC(=C)C(=O)OCCC[Si](C)(C)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/2759527,PubChem,C=C(C)C(=O)OCCC[Si](C)(C)Cl,Train "EU_REACH: tris(2-ethylhexyl) borate",,2467-13-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17438/7/4/2/?documentUUID=603c4086-a006-45a3-8818-7f3631a456f0,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,B(OCC(CC)CCCC)(OCC(CC)CCCC)OCC(CC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/17177,PubChem,CCCCC(CC)COB(OCC(CC)CCCC)OCC(CC)CCCC,Train "EU_REACH: 3-[(4-{2-[2-bromo-4-nitro-6-(trifluoromethyl)phenyl]diazen-1-yl}phenyl)(2-cyanoethyl)amino]propanenitrile",,246871-16-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15680/7/4/2/?documentUUID=8e3a15ea-2c7c-4d73-a780-0744c01395ce,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1N=NC2=C(C=C(C=C2Br)[N+](=O)[O-])C(F)(F)F)N(CCC#N)CCC#N,https://pubchem.ncbi.nlm.nih.gov/compound/11340904,PubChem,N#CCCN(CCC#N)c1ccc(N=Nc2c(Br)cc([N+](=O)[O-])cc2C(F)(F)F)cc1,Train "EU_REACH: 3-oxo-N-[4-(3-oxobutanamido)phenyl]butanamide",,24731-73-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5230/7/4/2/?documentUUID=eb1b79d0-9054-4b85-82a1-44bdb74845dd,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)CC(=O)NC1=CC=C(C=C1)NC(=O)CC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/90595,PubChem,CC(=O)CC(=O)Nc1ccc(NC(=O)CC(C)=O)cc1,Train "EU_REACH: 2-fluoro-5-methanesulfonylbenzoic acid",,247569-56-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5363/7/4/2/?documentUUID=8ec05912-2f46-453d-8603-a301b6abc2ea,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CS(=O)(=O)C1=CC(=C(C=C1)F)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/22467566,PubChem,CS(=O)(=O)c1ccc(F)c(C(=O)O)c1,Train "JP_CHRIP: Methyl(2-pentyl-3-oxocyclopentyl)acetate","JP_CHRIP: Cyclopentaneacetic acid, 3-oxo-2-pentyl-, methyl ester; Methyl dihydrojasmonate methyl (2-pentyl-3-oxo-cyclopentyl)acetate methyl 3-oxo-2-pentylcyclopentaneacetate methyl 3-oxo-2-pentylcyclopentylacetate",24851-98-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0068e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1) - (3). [Evidence Data] (1) It is reported that in a patch test in 111 persons, no skin irritation reactions were seen by a 20% solution of this substance (cis-: trans-isomer (about 10-12%: 88-90%)) (REACH registration dossier (Accessed Oct. 2020)). (2) It is reported that in a patch test in 100 persons, no skin irritation reactions were observed by a 20% solution of this substance (cis-: trans-isomer (about 75%: 25%)) (REACH registration dossier (Accessed Oct. 2020)). (3) It is reported that in a skin irritation test with rabbits (n = 3) on this substance (cis-: trans-isomer (about 30%: 70%)) (OECD TG 404, GLP, occlusive, 4-hour application, 72-hour observation), no skin irritation reactions were found in any animal (erythema/eschar score: 0/0/0, edema score: 0/0/0) (REACH registration dossier (Accessed Oct. 2020)).",Provided,JP_CHRIP,1,CCCCCC1C(CC(=O)OC)CCC1=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J87.287C,J-GLOBAL,CCCCCC1C(=O)CCC1CC(=O)OC,Train "EU_REACH: dec-1-en-4-yne",,24948-66-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32054/7/4/2/?documentUUID=82493ce3-1045-4cec-9d1a-9457dcd27018,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCC#CCC=C,https://pubchem.ncbi.nlm.nih.gov/compound/4321798,PubChem,C=CCC#CCCCCC,Train "EU_REACH: dioctadecyl disulphide",,2500-88-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32156/7/4/2/?documentUUID=5ed54a72-427e-4cdc-bbb0-993012593d8f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCCCSSCCCCCCCCCCCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/75627,PubChem,CCCCCCCCCCCCCCCCCCSSCCCCCCCCCCCCCCCCCC,Train "EU_REACH: 5-methyl-s-triazolo[1,5-a]pyrimidin-7-ol",,2503-56-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21778/7/4/2/?documentUUID=1bccd83d-6270-4016-8b2a-88a984890b08,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=O)N2C(=N1)N=CN2,https://pubchem.ncbi.nlm.nih.gov/compound/75629,PubChem,Cc1cc(=O)n2[nH]cnc2n1,Train "EU_REACH: 2-[(4-methyl-2-nitrophenyl)diazenyl]-3-oxo-N-phenylbutanamide",,2512-29-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13177/7/4/2/?documentUUID=577b01fb-5553-4f7b-bfae-c6c9f5a8175c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)N=NC(C(=O)C)C(=O)NC2=CC=CC=C2)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/221491,PubChem,CC(=O)C(N=Nc1ccc(C)cc1[N+](=O)[O-])C(=O)Nc1ccccc1,Train "EU_REACH: 2,4,4-trimethylpent-1-ene",,25167-70-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14774/7/4/2/?documentUUID=52e4d721-4981-45cd-9c05-92219da36d85,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)CC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/7868,PubChem,C=C(C)CC(C)(C)C,Train "EU_REACH: 3-methoxybutan-1-ol",,2517-43-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5155/7/4/2/?documentUUID=7331f061-6223-4a3d-b8c8-86f2874e7938,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CCO)OC,https://pubchem.ncbi.nlm.nih.gov/compound/17291,PubChem,COC(C)CCO,Train "EU_REACH: unnamed [252285-60-2]",,252285-60-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11244/7/4/2/?documentUUID=54e6ef13-f4f6-40cd-a7a3-c2b3d18f377d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC1=CC=C(C=C1)C2=NC(=NC(=N2)C3=CC=CC=C3)C4=CC=CC=C4O,https://pubchem.ncbi.nlm.nih.gov/compound/136146573,PubChem,CCOc1ccc(-c2nc(-c3ccccc3)nc(-c3ccccc3O)n2)cc1,Train "JP_CHRIP: Diethyl chlorothiophosphonate","JP_CHRIP: Diethyl chlorothiophosphate Diethyl phosphochloridothionate Phosphorochloridothioic acid O,O-diethylester",2524-04-1,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0204e.html,"JP_CHRIP: The substance was classified as Category 1 based on the document that the substance caused irritation after 3 minutes of application and caused corrosion after 1 hour of application in the rabbit test (OECD TG404).",Provided,JP_CHRIP,1,CCOP(=S)(Cl)OCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J34.649G,J-GLOBAL,CCOP(=S)(Cl)OCC,Train "NZ_CCID: Diphenyl phosphorochloridate","NZ_CCID: diphenyl chlorophosphate",2524-64-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/91C88312-D106-496B-8FBD-71A44271F05D,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)OP(=O)(OC2=CC=CC=C2)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/75654,PubChem,O=P(Cl)(Oc1ccccc1)Oc1ccccc1,Train "AU_HCIS: 1,2-Benzisothiazol-3(2H)-one, 2-methyl- KR_NCIS: 2-Methyl-1,2-benzisothiazolin-3-one","KR_NCIS: 2-methyl-1,2-benzisothiazol-3(2H)-one; 2-methyl-1,2-benzisothiazolin-3-one; 2-Methyl-1,2-benzoisothiazolin-3-one",2527-66-4,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=422 KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,"AU_HCIS, KR_NCIS",2,CN1C(=O)C2=CC=CC=C2S1,https://pubchem.ncbi.nlm.nih.gov/compound/351236,PubChem,Cn1sc2ccccc2c1=O,Train "KR_NCIS: 2,2'-(9-Octadecenylimino)bisethanol","KR_NCIS: 2,2'-(9-Octadecenylimino)bisethanol; Ethanol, 2,2'-(9-octadecen-1-ylimino)bis-; Ethanol, 2,2'-(9-octadecenylimino)bis-; Ethanol, 2,2'-(9-octadecenylimino)di-",25307-17-9,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCCCCCCC/C=C/CCCCCCCCN(CCO)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/6537107,PubChem,CCCCCCCC/C=C/CCCCCCCCN(CCO)CCO,Train "JP_CHRIP: 2-{[3-(Trimethoxysilyl)propoxy]methyl}oxirane","JP_CHRIP: 2-(6,6-Dimethoxy-2,7-dioxa-6-silaoctan-1-yl)oxirane [3-(2,3-epoxypropoxy)propyl]trimethoxysilane",2530-83-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0001e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1) - (3). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 6) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 14-day observation), slight irritation was observed in all the animals, which resolved completely after 14 days (erythema/eschar score: 1.7/1.7/1.7/1/1/1.3, edema score: 1.3/0.3/0.3/0/0/0.3) (REACH registration dossier (Accessed May 2020)). (2) It is reported that in a skin irritation test with rabbits (n = 6) (semi-occlusive, 24-hour application, 96-hour observation), erythema was found in all the animals 24 and 48 hours after removal of patches and persisted for 96 hours, but no edema was seen (erythema/eschar score: 1.7/2/1.7/2/2/2, edema score: 0.7/0/0/0/0/0) (SIDS (2004), REACH registration dossier (Accessed May 2020)). (3) It is reported that in a skin irritation test with rabbits (n = 4) (semi-occlusive, 24-hour application, 72-hour observation), skin primary irritation index (PII) = 0.06 (Non-irritant) (SIDS (2004), REACH registration dossier (Accessed May 2020)).",Provided,JP_CHRIP,1,CO[Si](CCCOCC1CO1)(OC)OC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J48.152A,J-GLOBAL,CO[Si](CCCOCC1CO1)(OC)OC,Train "NZ_CCID: Dimethylbenzenesulphonic acid",,25321-41-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D77558C3-0679-4B34-A89A-E0FE4B64D89B,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,Cc1cccc(c1C)[S](O)(=O)=O,https://cactus.nci.nih.gov/chemical/structure/25321-41-9/smiles,CACTUS,Cc1cccc(S(=O)(=O)O)c1C,Train "EU_REACH: quinuclidin-3-ol",,25333-42-0,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25385/7/4/2/?documentUUID=d427dccb-cd32-406e-b270-fe959c49a1c3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CN2CCC1[C@H](C2)O,https://pubchem.ncbi.nlm.nih.gov/compound/91404,PubChem,O[C@H]1CN2CCC1CC2,Train "EU_REACH: 2-hexyldecanoic acid",,25354-97-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27833/7/4/2/?documentUUID=b747aa5f-c2ca-41ab-ae95-1070b493c9e3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCC(CCCCCC)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/32912,PubChem,CCCCCCCCC(CCCCCC)C(=O)O,Train "EU_REACH: 3,5-dimethylheptane-3-thiol",,25360-10-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12041/7/4/2/?documentUUID=7f7fdf43-9631-4818-a971-882e6c8101ca,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCC(C)(C)S,https://pubchem.ncbi.nlm.nih.gov/compound/520196,PubChem,CCCCCCC(C)(C)S,Train "NZ_CCID: Diethyl cyanomethylphosphonate",,2537-48-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5A6B591F-3576-44AF-98BB-67149857C8EA,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCOP(=O)(CC#N)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/75676,PubChem,CCOP(=O)(CC#N)OCC,Train "EU_REACH: tridec-1-ene",,25377-82-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2007/7/4/2/?documentUUID=8dcfd306-3eb2-423f-a177-5f141bb0b0de,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCC/C=C/C,https://pubchem.ncbi.nlm.nih.gov/compound/5364435,PubChem,C/C=C/CCCCCCCCCC,Train "EU_REACH: tetradecyl methacrylate",,2549-53-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14692/7/4/2/?documentUUID=470e6cff-3a66-430b-a8a3-0c81a71ef768,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCOC(=O)C(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/17351,PubChem,C=C(C)C(=O)OCCCCCCCCCCCCCC,Train "EU_REACH: (Z)-tetrahydro-6-(2-pentenyl)-2H-pyran-2-one",,25524-95-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32953/7/4/2/?documentUUID=38f6f2f2-62c8-4c31-901b-ecf74e60f618,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC/C=C\CC1CCCC(=O)O1,https://pubchem.ncbi.nlm.nih.gov/compound/5352626,PubChem,CC/C=C\CC1CCCC(=O)O1,Train "JP_CHRIP: Hexabromocyclododecane","JP_CHRIP: cyclododecane, hexabromo Cyclododecane, hexabromo-; Cyclododecane,hexabromo-; Hexabromocyclododecane Cyclododecane, hexabromo-isomers",25637-99-4,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0013e.html,"JP_CHRIP: In a skin irritation study using rabbits (OECD TG 404), very slight erythema was observed, but the irritation was concluded to be negative (EU-RAR (2008), NICNAS (2012)). Therefore, the substance was classified as ""Not classified.""",Provided,JP_CHRIP,1,BrC1(Br)C(Br)(Br)C(Br)(Br)CCCCCCCCC1,https://www.nite.go.jp/en/chem/chrip/chrip_search/cmpInfDsp?cid=C004-784-59A&slScNm=CI_01_001&bcPtn=3,CHRIP,BrC1(Br)CCCCCCCCCC(Br)(Br)C1(Br)Br,Train "NZ_CCID: 2,2,6,6-Tetramethylpiperidine-1-oxyl",,2564-83-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/90BE00D1-E7A7-40A6-A4AC-881E32DC208B,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC1(CCCC(N1[O])(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/2724126,PubChem,CC1(C)CCCC(C)(C)N1[O],Train "EU_REACH: 1,3-Cyclohexanedimethanamine JP_CHRIP: 1,3-Bis(aminomethyl)cyclohexane","JP_CHRIP: 1,3-bis(aminomethyl)cyclohexane 1,3-Bis(aminomethyl)cyclohexane; 1,3-Bis(aminomethyl)cyclohexane 1,3-Cyclohexanedimethanamine",2579-20-6,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15661/7/4/2/?documentUUID=49923ed2-1d3c-461a-8411-ab74f599e52a JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0118e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: In a skin irritation test in which 0.5 mL of the test substance was applied to one rabbit for 3 minutes, Draize irritation scores after 1 hour were 4 for erythema and 0 for edema, and green-colored necrosis, loss of elasticity, and dryness were observed in the skin, and it was assessed to be corrosive (NICNAS (2001)). Therefore, it was classified in Category 1A.",Provided,"EU_REACH, JP_CHRIP",2,NCC1CCCC(CN)C1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J48.534I,J-GLOBAL,NCC1CCCC(CN)C1,Train "AU_HCIS: 9,12-Octadecadien-1-amine, (Z,Z)-",,25876-34-0,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5635,,,AU_HCIS,1,CCCCC/C=C\C/C=C\CCCCCCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/6438044,PubChem,CCCCC/C=C\C/C=C\CCCCCCCCN,Train "EU_REACH: 3,4-dihydro-2H-1,4-benzoxazin-6-ol",,26021-57-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32979/7/4/2/?documentUUID=99e9b8a2-44f8-4e1b-9fb9-b7fea55c1e52,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1COC2=C(N1)C=C(C=C2)O,https://pubchem.ncbi.nlm.nih.gov/compound/117709,PubChem,Oc1ccc2c(c1)NCCO2,Train "EU_REACH: triethoxy[3-(oxiran-2-ylmethoxy)propyl]silane",,2602-34-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14188/7/4/2/?documentUUID=68a1dcda-b1c5-4118-87e3-cc6c74818372,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](CCCOCC1CO1)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/102856,PubChem,CCO[Si](CCCOCC1CO1)(OCC)OCC,Train "EU_REACH: 1,2-bis(2-ethylhexyl) 3,4,5,6-tetrabromobenzene-1,2-dicarboxylate",,26040-51-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10235/7/4/2/?documentUUID=ee2de800-138e-4b34-98fb-1848c8685d64,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)C1=C(C(=C(C(=C1Br)Br)Br)Br)C(=O)OCC(CC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/117291,PubChem,CCCCC(CC)COC(=O)c1c(Br)c(Br)c(Br)c(Br)c1C(=O)OCC(CC)CCCC,Train "EU_REACH: decyl(dimethyl)amine oxide",,2605-79-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5684/7/4/2/?documentUUID=8a3114d6-812b-4505-929f-3d8a27e01539,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCC[N+](C)(C)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/62452,PubChem,CCCCCCCCCC[N+](C)(C)[O-],Train "EU_REACH: 1-[({[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}carbonyl)oxy]propan-2-ol",,260781-16-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23304/7/4/2/?documentUUID=2bc355a1-3854-4656-a334-8c0575fdd981,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H]1CC[C@H]([C@@H](C1)OC(=O)OCC(C)O)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/57509244,PubChem,CC(O)COC(=O)O[C@@H]1C[C@H](C)CC[C@H]1C(C)C,Train "KR_NCIS: 5-Chloro-2-methyl-4-isothiazolin-3-one NZ_CCID: 4-Isothiazolin-3-one, 5-chloro-2-methyl-","NZ_CCID: 5-Chloro-2-methyl-4-isothiazolin-3-one",26172-55-4,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/ACA62E2C-A773-45A4-8C04-603D11A5AD62","NZ_CCID: Skin Irritation SPECIES: Rabbit RESULT: Corrosive REFERENCE SOURCE: THOR CHEMIE GMBH Speyer [iuclid 2000] REMARK: EC Classification: Corrosive (causes burns) CUTOFFS: 8.2B Corrosive at 0.6% and above 6.3A Irritant at 0.06% and above [[ECB for CAS # 55965-84-9] Eye Irritation SPECIES: Rabbit RESULT: Highly irritating REFERENCE SOURCE: THOR CHEMIE GMBH Speyer [IUCLID 2000] REMARK: EC Classification: Irritating CUTOFFS: 8.3A Corrosive at 0.6% and above 6.4A Irritant at 0.06% and above [ECB for CAS # 55965-84-9]",,"KR_NCIS, NZ_CCID",2,CN1C(=O)C=C(S1)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/33344,PubChem,Cn1sc(Cl)cc1=O,Train "EU_REACH: (1E)-1-(methoxyimino)-1-(2,5,5-trimethyl-1,3-dioxan-2-yl)acetone",,263355-39-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6388/7/4/2/?documentUUID=4d45c9f9-fd50-40e5-9049-61917fbd4b16,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)/C(=N\OC)/C1(OCC(CO1)(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/88152585,PubChem,CO/N=C(\C(C)=O)C1(C)OCC(C)(C)CO1,Train "EU_REACH: [(1,3-thiazolidin-2-ylidene)amino]formonitrile",,26364-65-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/3973/7/4/2/?documentUUID=09398107-f635-4c8d-acb8-7c10353592df,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CSC(=N1)NC#N,https://pubchem.ncbi.nlm.nih.gov/compound/3700797,PubChem,N#CNC1=NCCS1,Train "EU_REACH: 4,4'-azobis[4-cyanovaleric] acid",,2638-94-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22344/7/4/2/?documentUUID=d476a90f-8273-4331-ad8a-fa63904937ec,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CCC(=O)O)(C#N)N=NC(C)(CCC(=O)O)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/92938,PubChem,CC(C#N)(CCC(=O)O)N=NC(C)(C#N)CCC(=O)O,Train "EU_REACH: diisotridecyl adipate (DITA)",,26401-35-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16101/7/4/2/?documentUUID=54019d71-740b-4d46-b8e7-37a7daf5c268,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCCCCCCOC(=O)CCCCC(=O)OCCCCCCCCCCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/94369,PubChem,CC(C)CCCCCCCCCCOC(=O)CCCCC(=O)OCCCCCCCCCCC(C)C,Train "EU_REACH: Di-2-thienylglycolic acid methyl ester",,26447-85-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6427/7/4/2/?documentUUID=913534b9-3b74-4574-b9db-10b23a736dea,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C(C1=CC=CS1)(C2=CC=CS2)O,https://pubchem.ncbi.nlm.nih.gov/compound/11414137,PubChem,COC(=O)C(O)(c1cccs1)c1cccs1,Train "EU_REACH: N-[(triethoxysilyl)methyl]cyclohexanamine",,26495-91-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24988/7/4/2/?documentUUID=8d55de31-6807-4e86-9df4-c460580e38b9,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](CNC1CCCCC1)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/11818203,PubChem,CCO[Si](CNC1CCCCC1)(OCC)OCC,Train "AU_HCIS: octhilinone (ISO) JP_CHRIP: 2-n-Octyl-4-isothiazolin-3-one KR_NCIS: 2-Octyl-3(2H)-isothiazolone NZ_CCID: Octhilinone US_HSDB: Octhilinone","AU_HCIS: 2-octyl-2H-isothiazol-3-one 3(2H)-Isothiazolone, 2-octyl- KR_NCIS: 2-N-Octyl-4-Isothiazolin-3-One; 3(2H)-Isothiazolone, 2-Octyl-; 2-Octyl-2H-Isothiazol-3-One, Octhilinone NZ_CCID: 2-Octyl-3-isothiazolone, 3(2H)-Isothiazolone, 2-octyl-, 2-n-Octyl-4-isothiazolin-3-one",26530-20-1,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3303 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0091e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D32A6E24-D388-4BA6-9D4D-5EFFE2F1182E US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/6713","JP_CHRIP: From severe erythema and edema accompanied by scab formation and tissue damage, a maximal score of 8.0, and ""corrosive"" classification in a test applied 0.5 mL of a 45 to 50% solution in propylene glycol to rabbit skins for 4 hours (DFGMAK-Doc. 16 (2001)), it was classified in Category 1. NZ_CCID: Skin Irritation SPECIES: RESULT: This compound is corrosive to tissues. REFERENCE SOURCE: (Rohm and Haas Company. Shipping Authorization for Skane HG. Spring House, PA. August 22, 1985.) [NTP] R-PHRASE: R 34 Causes burns. [NCLASS] Eye Irritation SPECIES: RESULT: Severe irritation REFERENCE SOURCE: (Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial Materials. 7th Ed. Van Nostrand Reinhold. New York. 1989. Vol. III, p. 2609, #OFE000.) [NTP]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,CCCCCCCCn1sccc1=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J10.439F,J-GLOBAL,CCCCCCCCn1sccc1=O,Train "EU_REACH: 2-chloro-N-methyl-N-(4-nitrophenyl)acetamide",,2653-16-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27267/7/4/2/?documentUUID=4d6cd41d-40cd-4853-aa24-c3c5839b0284,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C1=CC=C(C=C1)[N+](=O)[O-])C(=O)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/11436129,PubChem,CN(C(=O)CCl)c1ccc([N+](=O)[O-])cc1,Train "EU_REACH: 3-oxo-N-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)butanamide",,26576-46-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1884/7/4/2/?documentUUID=31160cee-a6ea-4a0f-b8f9-0b53b9d8d8f6,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)CC(=O)NC1=CC2=C(C=C1)NC(=O)N2,https://pubchem.ncbi.nlm.nih.gov/compound/117822,PubChem,CC(=O)CC(=O)Nc1ccc2[nH]c(=O)[nH]c2c1,Train "NZ_CCID: 9-Octadecenamide, N,N-dimethyl-, (9Z)-",,2664-42-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/038DB0C6-F718-40CB-94A6-D90FEC238C10,,,NZ_CCID,1,CCCCCCCC/C=C\CCCCCCCC(=O)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/5356959,PubChem,CCCCCCCC/C=C\CCCCCCCC(=O)N(C)C,Train "EU_REACH: N4-Benzoylcytosine",,26661-13-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22698/7/4/2/?documentUUID=1d4071e4-464a-4526-b4c6-49e80bcfc191,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C(=O)NC2=CC=NC(=O)N2,https://pubchem.ncbi.nlm.nih.gov/compound/309343,PubChem,O=C(Nc1ccnc(=O)[nH]1)c1ccccc1,Train "KR_NCIS: 2-Methoxy-4-(2-sulfatoethylsulfonyl)aniline",,26672-22-0,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,COC1=C(C=CC(=C1)S(=O)(=O)CCOS(=O)(=O)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/12116239,PubChem,COc1cc(S(=O)(=O)CCOS(=O)(=O)O)ccc1N,Train "EU_REACH: 1-methyl-1-phenylethyl 2-ethyl-2,5-dimethylhexaneperoxoate",,26748-47-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24271/7/4/2/?documentUUID=f4fd5ed7-6a0e-42fb-8d5e-14c91e7b1693,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)CCCCCC(=O)OOC(C)(C)c1ccccc1,https://cactus.nci.nih.gov/chemical/structure/26748-47-0/smiles,CACTUS,CC(C)(C)CCCCCC(=O)OOC(C)(C)c1ccccc1,Train "JP_CHRIP: Diisodecyl phthalate [DIDP]","JP_CHRIP: 1,2-benzenedicarboxylic acid, diisodecyl ester bis(8-Methylnonyl) phthalate di-''isodecyl'' phthalate DIDP diisodecyl benzene-1,2-dicarboxylate",26761-40-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0127e.html,"JP_CHRIP: In a skin irritation test (OECD TG 404) using rabbits, transient very slight irritation was observed. Moreover, in other rabbit skin irritation tests (4-hour application), skin irritation was transient and very slight (EU-RAR (2003), DFGOT (2015)). Also, in a human patch test, when applying 0.2 mL occlusively for 24 hours to 15 subjects, irritation was not observed in the examinations at 30 minutes and 24 hours after patch removal (EU-RAR (2003)). Based on these results, it was judged to be classified as ""Not classified"" (Category 3 in UN GHS classification).",Provided,JP_CHRIP,1,CC(C)CCCCCCCOC(=O)c1ccccc1C(=O)OCCCCCCCC(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.799K,J-GLOBAL,CC(C)CCCCCCCOC(=O)c1ccccc1C(=O)OCCCCCCCC(C)C,Train "EU_REACH: (oxiran-2-yl)methyl 2,2-dimethyloctanoate",,26761-45-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1888/7/4/2/?documentUUID=afeab056-6d26-470f-8075-09180e937b0b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C)(CCC(C)C)C(=O)OCC1CO1,https://cactus.nci.nih.gov/chemical/structure/26761-45-5/smiles,CACTUS,CCC(C)(CCC(C)C)C(=O)OCC1CO1,Train "AU_HCIS: Methylisothiazolone KR_NCIS: 2-Methyl-4-isothiazolin-3-one NZ_CCID: 2-Methyl-3(2H)-isothiazolone US_HSDB: Methylisothiazolinone","AU_HCIS: Isothiazolone, 2-methyl- 3-Methylisothiazolone 2- Methylisothiazol-3(2H)-one KR_NCIS: 2-Methyl-2H-isothiazol-3-one NZ_CCID: 2-Methyl-4-isothiazolin-3-one, 2-Methyl-2H-isothiazol-3-one, 3(2H)-Isothiazolone, 2-methyl-, MIT",2682-20-4,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4839 KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6F0425B2-2E68-4A2A-B6DE-CE8AFC264576 US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8200","NZ_CCID: Skin Irritation REMARK: The a.i. in Kathon 886 (usually containing 13 400 mg/l) and CG (usually containing 15 000 mg/l) were corrosive when tested undiluted. Aqueous dilutions of a.i. with concentrations of 560 mg/l were nonirritating; 2 800 mg/l was slightly to moderately irritating; 5 600 -17 000 mg/l were moderately to severely irritating; and > 28 000 mg/l were corrosive. Skin Irritation produced by methylchloroisothiazolinone and methylisothiazolinone was concentration dependent. Undiluted a.i. in Kathon CG and 886 were severely irritating to rabbit skin. REFERENCE SOURCE: Nordic Chemicals Group Health effects of selected chemicals 2. Kathon and 5-chloro-2-methyl-4-isotihazolin-3-one and 2-methyl-isothiazolin-3-one Nord PG:75-104 YR:1993 IP: VI:29 [toxline] Eye Irritation REMARK: The a.i. in Kathon 886 (usually containing 13 400 mg/l) and CG (usually containing 15 000 mg/l) were corrosive when tested undiluted. Aqueous dilutions of a.i. with concentrations of 560 mg/l were nonirritating; 2 800 mg/l was slightly to moderately irritating; 5 600 -17 000 mg/l were moderately to severely irritating; and > 28 000 mg/l were corrosive. Under occlusive patches, aqueous dilutions of a.i. containing 560 mg/l were nonirritating; 2 800 mg/l was moderately irritating, 5 600 mg/l was severely irritating; and 56 000 mg/l was corrosive. REFERENCE SOURCE: Nordic Chemicals Group Health effects of selected chemicals 2. Kathon and 5-chloro-2-methyl-4-isotihazolin-3-one and 2-methyl-isothiazolin-3-one Nord PG:75-104 YR:1993 IP: VI:29 [toxline]",,"AU_HCIS, KR_NCIS, NZ_CCID, US_HSDB",4,CN1C(=O)C=CS1,https://pubchem.ncbi.nlm.nih.gov/compound/39800,PubChem,Cn1sccc1=O,Train "EU_REACH: 3-hydroxy-N-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-2-naphthamide",,26848-40-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21197/7/4/2/?documentUUID=6d6354c0-803f-4490-9ee9-224b54fcc1d1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C=C(C(=CC2=C1)C(=O)NC3=CC4=C(C=C3)NC(=O)N4)O,https://pubchem.ncbi.nlm.nih.gov/compound/117877,PubChem,O=C(Nc1ccc2[nH]c(=O)[nH]c2c1)c1cc2ccccc2cc1O,Train "EU_REACH: 3-{[bis(2-methylpropoxy)(sulfanylidene)-λ⁵-phosphanyl]sulfanyl}-2-methylpropanoic acid",,268567-32-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5213/7/4/2/?documentUUID=b91d561e-f87b-4c2f-acc7-97d955ac2ab1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)COP(=S)(OCC(C)C)SCC(C)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/57357853,PubChem,CC(C)COP(=S)(OCC(C)C)SCC(C)C(=O)O,Train "EU_REACH: 1-octylpyrrolidin-2-one NZ_CCID: 2-Pyrrolidinone, 1-octyl-","NZ_CCID: 1-Octyl-2-pyrrolidinone, 1-Octyl-2-pyrrolidone, N-Octylpyrrolidinone, N-Octylpyrrolidone",2687-94-7,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16946/7/4/2/?documentUUID=4c4715ab-7fdd-4370-9dc4-978ee3aa6663 NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F1A97CC4-DFD5-4184-AD2C-00627D59974F","EU_REACH: Experimental study (OECD TG 404, GLP) NZ_CCID: Skin Irritation R-PHRASE: R 34 Causes Burns. [ECB - Annex 1] Eye Irritation R-PHRASE: R 34 Causes Burns. [ECB - Annex 1]",Provided,"EU_REACH, NZ_CCID",2,CCCCCCCCN1CCCC1=O,https://pubchem.ncbi.nlm.nih.gov/compound/3033871,PubChem,CCCCCCCCN1CCCC1=O,Train "NZ_CCID: 1-Dodecyl-2-pyrrolidone","NZ_CCID: 2-Pyrrolidinone, 1-dodecyl-",2687-96-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4656290C-E345-4B58-A5F8-3CDDBAD82F2E,"NZ_CCID: Skin Irritation R-PHRASE: R 34 [N-CLASS] Eye Irritation R-PHRASE: R 34 Causes burns.",,NZ_CCID,1,CCCCCCCCCCCCN1CCCC1=O,https://pubchem.ncbi.nlm.nih.gov/compound/62459,PubChem,CCCCCCCCCCCCN1CCCC1=O,Train "JP_CHRIP: 2-Chlorobenzylidenemalononitrile","JP_CHRIP: (o-Chlorobenzal)malononitrile 2-Chlorobenzylidene malononitrile 2-Chlorobenzylidenemalononitrile [(2-Chlorophenyl)methylene]propanedinitrile [2-(Chlorophenyl)methylene]malononitrile beta,beta-Dicyano-o-chlorostyrene CS (riot control agent) Propanedinitrile, [(2-chlorophenyl)methylene]-",2698-41-1,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2003e.html,"JP_CHRIP: [Rationale for the Classification] It was classified in Category 1 from (1) - (3). [Evidence Data] (1) This substance is a strong irritant, direct exposure causes irritation of the mucous membranes, and also in humans, irritation by this substance is reported (US AEGL (2014)). (2) This substance is used as an incapacitating agent for riot control and causes intense skin and eye irritation in humans, and direct exposure produces eye irritation, lacrimation, conjunctivitis, and skin burning (ACGIH (7th, 2019), HSDB (Access on April 2020)). (3) It is severely irritating to the skin and eye (GESTIS (Access on April 2020)). [Reference Data, etc.] (4) In a skin corrosion test by reconstructed epidermis model (Episkin) (OECD TG 431), this substance (5%) was shown to be not corrosive, and in a test similar to OECD TG 439, it was proven to be an irritant (REACH registration dossier (Access on May 2020)).",,JP_CHRIP,1,Clc1ccccc1C=C(C#N)C#N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J14.332D,J-GLOBAL,N#CC(C#N)=Cc1ccccc1Cl,Train "EU_REACH: N~3~-(2-hydroxyethyl)-beta-alaninamide",,27076-30-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11896/7/4/2/?documentUUID=c639439e-c835-4bd0-b0e3-77c6391bb267,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CNCCO)C(=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/117919,PubChem,NC(=O)CCNCCO,Train "EU_REACH: 1-[2-(benzoyloxy)propoxy]propan-2-yl benzoate; 1-{[1-(benzoyloxy)propan-2-yl]oxy}propan-2-yl benzoate; 2-{[1-(benzoyloxy)propan-2-yl]oxy}propyl benzoate",,27138-31-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13387/7/4/2/?documentUUID=66d89daf-d896-4d1e-aacc-251192399dc4,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(COCC(C)OC(=O)C1=CC=CC=C1)OC(=O)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/101560,PubChem,CC(COCC(C)OC(=O)c1ccccc1)OC(=O)c1ccccc1,Train "NZ_CCID: Cyclohexanecarboxylic acid chloride","NZ_CCID: cyclohexanecarbonyl chloride",2719-27-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7B2530CB-DBD7-4B83-8315-C1DFBB8A1613,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CCC(CC1)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/75938,PubChem,O=C(Cl)C1CCCCC1,Train "AU_HCIS: Phenol, (1,1,3,3-tetramethylbutyl)-",,27193-28-8,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5806,,,AU_HCIS,1,CC(C)(C)CC(C)(C)C1=CC=CC=C1O,https://pubchem.ncbi.nlm.nih.gov/compound/62530,PubChem,CC(C)(C)CC(C)(C)c1ccccc1O,Train "AU_HCIS: 1,2-Benzenediol, (1,1-dimethylethyl)-",,27213-78-1,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6587,,,AU_HCIS,1,CC(C)(C)c1cccc(O)c1O,https://cactus.nci.nih.gov/chemical/structure/27213-78-1/smiles,CACTUS,CC(C)(C)c1cccc(O)c1O,Train "JP_CHRIP: N-[4-(1,1,1,2,3,3,3-Heptafluoropropan-2-yl)-2-methylphenyl]-3-iodo-N'-[2-methyl-1-(methylsulfonyl)propan-2-yl]phthalamide; Flubendiamide","JP_CHRIP: 3-Iodo-N2-[2-methyl-1-(methylsulfonyl)propan-2-yl]-N1-[2-methyl-4-(perfluoropropan-2-yl)phenyl]phthalamide",272451-65-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0077e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 72-hour observation), no irritation changes were seen in any animal (erythema/eschar score: 0/0/0, edema score: 0/0/0) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2019), JMPR (2010), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2015)).",Provided,JP_CHRIP,1,Cc1cc(ccc1NC(=O)c1cccc(I)c1C(=O)NC(C)(C)CS(=O)(=O)C)C(F)(C(F)(F)F)C(F)(F)F,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.180.104F,J-GLOBAL,Cc1cc(C(F)(C(F)(F)F)C(F)(F)F)ccc1NC(=O)c1cccc(I)c1C(=O)NC(C)(C)CS(C)(=O)=O,Train "JP_CHRIP: 2-Ethylhexyl nitrate",,27247-96-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0043e.html,"JP_CHRIP: On the basis of the ""not irritating"" evaluation as a result of a test applied to rabbit skins for 4 hours (OECD TG 404, GLP), in which skin reactions were not observed until 24 hours after application and minimal to slight erythema observed at 1 or 2 animals in 48 to 124 hours disappeared after 148 hours (IUCLID (2000)), it was classified as ""Not classified.""",Provided,JP_CHRIP,1,CCCCC(CC)CO[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J154.004A,J-GLOBAL,CCCCC(CC)CO[N+](=O)[O-],Train "EU_REACH: octadecane-1,12-diol",,2726-73-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17479/7/4/2/?documentUUID=d944d2a6-3f6d-4237-b628-227c7febb79c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCC(CCCCCCCCCCCO)O,https://pubchem.ncbi.nlm.nih.gov/compound/95421,PubChem,CCCCCCC(O)CCCCCCCCCCCO,Train "EU_REACH: 1-[bis(4-fluorophenyl)methyl]piperazine",,27469-60-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23189/7/4/2/?documentUUID=ae5825be-f25e-444e-85a1-9a76aed7c663,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CN(CCN1)C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F,https://pubchem.ncbi.nlm.nih.gov/compound/152932,PubChem,Fc1ccc(C(c2ccc(F)cc2)N2CCNCC2)cc1,Train "KR_NCIS: Trimethylsilyl trifluoromethanesulfonate NZ_CCID: Trimethylsilyl trifluoromethanesulphonate","NZ_CCID: trimethylsilyl trifluoromethanesulfonate",27607-77-8,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D968ACFF-3943-4C6C-BC7D-E00A448192F2","NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"KR_NCIS, NZ_CCID",2,C[Si](C)(C)OS(=O)(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/65367,PubChem,C[Si](C)(C)OS(=O)(=O)C(F)(F)F,Train "EU_REACH: 2-butyloctanoic acid",,27610-92-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20154/7/4/2/?documentUUID=12e432dc-139c-49bd-b8a6-13302ed55fea,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCC(CCCC)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/33970,PubChem,CCCCCCC(CCCC)C(=O)O,Train "EU_REACH: 1,3,5-tris(3,5-di-tert-butyl-4-hydroxybenzyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione",,27676-62-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14358/7/4/2/?documentUUID=e5aee7f1-8861-46e7-9f5b-df7d55108d01,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CN2C(=O)N(C(=O)N(C2=O)CC3=CC(=C(C(=C3)C(C)(C)C)O)C(C)(C)C)CC4=CC(=C(C(=C4)C(C)(C)C)O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/93115,PubChem,CC(C)(C)c1cc(Cn2c(=O)n(Cc3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)c(=O)n(Cc3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)c2=O)cc(C(C)(C)C)c1O,Train "EU_REACH: 3-{4-[2-(4-{3-[(2-methylprop-2-enoyl)oxy]propoxy}phenyl)propan-2-yl]phenoxy}propyl 2-methylprop-2-enoate",,27689-12-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16429/7/4/2/?documentUUID=3f6dd2cd-5941-4875-b8c4-1fc813b23b90,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OCCCOC1=CC=C(C=C1)C(C)(C)C2=CC=C(C=C2)OCCCOC(=O)C(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/94384,PubChem,C=C(C)C(=O)OCCCOc1ccc(C(C)(C)c2ccc(OCCCOC(=O)C(=C)C)cc2)cc1,Train "KR_NCIS: Bis(diethylamino)silane",,27804-64-4,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCN(CC)[Si]N(CC)CC,https://pubchem.ncbi.nlm.nih.gov/compound/14908161,PubChem,CCN(CC)[Si]N(CC)CC,Train "JP_CHRIP: 1-Hydroxyethane-1,1-diylbis(phosphonic acid)","JP_CHRIP: 1-Hydroxyethane-1,1-diphosphonic acid; 1-Hydroxyethylidene-1,1-diphosphonic acid etidronic acid",2809-21-4,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0127e.html,"JP_CHRIP: It was classified in Category 1 because it is described that the pH of the saturated aqueous solution was < 2 (IUCLID (2000)). Besides, it is also reported that it was moderately irritating in a test with rabbits (HERA (2004)).",,JP_CHRIP,1,CC(O)(P(=O)(O)O)P(=O)(O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J7.915D,J-GLOBAL,CC(O)(P(=O)(O)O)P(=O)(O)O,Train "EU_REACH: 1-[(2-chloro-4-nitrophenyl)diazenyl]-2-naphthol",,2814-77-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13624/7/4/2/?documentUUID=f431b5f6-8b29-4b7c-a566-1840127568bb,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)C=CC(=C2N=NC3=C(C=C(C=C3)[N+](=O)[O-])Cl)O,https://pubchem.ncbi.nlm.nih.gov/compound/17778,PubChem,O=[N+]([O-])c1ccc(N=Nc2c(O)ccc3ccccc23)c(Cl)c1,Train "EU_REACH: 2-[(1-amino-4-hydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)oxy]ethyl phenyl carbonate",,28173-59-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11449/7/4/2/?documentUUID=619d5a79-082b-406d-b88e-a79457211518,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)OC(=O)OCCOC2=C(C3=C(C(=C2)O)C(=O)C4=CC=CC=C4C3=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/119885,PubChem,Nc1c(OCCOC(=O)Oc2ccccc2)cc(O)c2c1C(=O)c1ccccc1C2=O,Train "NZ_CCID: 3-(Bromomethyl)-benzonitrile",,28188-41-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E3E8E4A2-D699-493B-8970-3581D06D310E,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)C#N)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/97249,PubChem,N#Cc1cccc(CBr)c1,Train "EU_REACH: Benzene, 1,1'-oxybis[methyl-",,28299-41-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10988/7/4/2/?documentUUID=0024652e-5a33-4c5c-8b46-55cca3524868,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,Cc1ccccc1Oc2ccccc2C,https://cactus.nci.nih.gov/chemical/structure/28299-41-4/smiles,CACTUS,Cc1ccccc1Oc1ccccc1C,Train "EU_REACH: 4-aminobenzamide",,2835-68-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11042/7/4/2/?documentUUID=3a8ba9a4-0f9b-4283-8963-e22318708054,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1C(=O)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/76079,PubChem,NC(=O)c1ccc(N)cc1,Train "EU_REACH: 2-amino-5-chlorophenol",,28443-50-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12346/7/4/2/?documentUUID=2f1f4314-7845-4274-b589-bc5adcf52ec3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C=C1Cl)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/91591,PubChem,Nc1ccc(Cl)cc1O,Train "EU_REACH: 4-(4-((((4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)AMINO)CARBONYL)AMINO)PHENOXY)-N-METHYL-2-PYRIDINECARBOXAMIDE",,284461-73-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6884/7/4/2/?documentUUID=f6b8e03a-392f-48c3-af53-f6774fda4d2e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/216239,PubChem,CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1,Train "EU_REACH: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide",,284462-37-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8171/7/4/2/?documentUUID=0bfe352c-870b-4dcc-9434-1565250ea030,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)N,https://pubchem.ncbi.nlm.nih.gov/compound/16655129,PubChem,CNC(=O)c1cc(Oc2ccc(N)cc2)ccn1,Train "AU_HCIS: 3-aminomethyl-3,5,5-trimethylcyclohexylamine JP_CHRIP: 3-aminomethyl-3,5,5-trimethylcyclohexylamine NZ_CCID: Isophoronediamine","AU_HCIS: Cyclohexanemethanamine, 5-amino-1,3,3-trimethyl- JP_CHRIP: 1-amino-3-aminomethyl-3,3,5-trimethylcyclohexane 3-(aminomethyl)-3,5,5-trimethylcyclohexylamine NZ_CCID: 3-Aminomethyl-3,5,5-trimethylcyclohexylamine, 5-Amino-1,3,3-trimethylcyclohexanemethylamine, Cyclohexanemethanamine, 5-amino-1,3,3,-trimethyl-, Cyclohexanemethylamine, 5-amino-1,3,3-trimethyl-, Isophorone diamine",2855-13-2,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=206 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0060e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B7F04EB2-EC22-43E1-9106-B9B04051AE81","JP_CHRIP: In the tests using rabbits and rats, the substance induced edemas and caused irritation and inflammation (SIDS (accessed in July 2008). In addition, its pH is 11.6 (8.5g/L, 20degC). Based on the information, the substance was classified into Category 1. Repeated exposure resulted in severe effects with incrustation and necrosis, and the substance has been classified into R34 in the EU classification (EU-Annex (accessed in July 2008)). NZ_CCID: Skin Irritation R PHRASE: R 34 [N-CLASS] Eye Irritation R PHRASE: R 34 [N-CLASS]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CC1(C)CC(N)CC(C)(CN)C1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J68.532A,J-GLOBAL,CC1(C)CC(N)CC(C)(CN)C1,Train "KR_NCIS: Bromotrimethylsilane NZ_CCID: Bromotrimethylsilane","NZ_CCID: trimethylbromosilane",2857-97-8,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5EE3FDB4-B770-4158-95E5-0FE671E9F5FE","NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"KR_NCIS, NZ_CCID",2,C[Si](C)(C)Br,https://pubchem.ncbi.nlm.nih.gov/compound/76113,PubChem,C[Si](C)(C)Br,Train "EU_REACH: (2,5-dimethyl-2,3-dihydro-1H-inden-2-yl)methanol",,285977-85-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/28258/7/4/2/?documentUUID=bf5dc3f3-c61e-499e-a7db-a83f1d0b3d0c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC2=C(CC(C2)(C)CO)C=C1,https://pubchem.ncbi.nlm.nih.gov/compound/11367306,PubChem,Cc1ccc2c(c1)CC(C)(CO)C2,Train "NZ_CCID: Epoxycyclohexane","NZ_CCID: cyclohexene oxide",286-20-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5B84221A-B604-4B4C-A7B0-CC782535B958,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CCC2C(C1)O2,https://pubchem.ncbi.nlm.nih.gov/compound/9246,PubChem,C1CCC2OC2C1,Train "JP_CHRIP: 2-(Dimethylamino)ethyl methacrylate NZ_CCID: 2-Propenoic acid, 2-methyl-, 2-(dimethylamino)ethyl ester, (dimethylaminoethyl methacrylate) US_HSDB: N,N-DIMETHYLAMINOETHYL METHACRYLATE","JP_CHRIP: 2-dimethylaminoethyl methacrylate Dimethylamino-ethylmethacrylate dimethylaminoethyl methacrylate Methacrylic acid, 2-(dimethylamino)ethyl ester N,N-Dimethylaminoethyl methacrylate NZ_CCID: Dimethylaminoethylmethacrylate",2867-47-2,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/07-meti-2030e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/17929F50-404B-4284-B8CB-700FAB5633AB US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/5464","JP_CHRIP: It is classified as ""Category 1A-1C""in the three-ministry GHS division. Since UN GHS Document 3.2.2.4.2 says, ""For those authorities wanting more than one designation for corrosion, up to three sub-categories are provided within the corrosive category."" subdividing is not essential. It is therefore preferable to modify ""Category 1A-1C"" to ""Category 1"" from the view point of text representation as well. NZ_CCID: Skin Irritation SPECIES: Rabbit RESULT: Corrosive REFERENCE SOURCE: Atochem Paris la Defense (33) Report Consultox Laboratories Ltd. CL80 65 2030 (May 1980). [IUCLID 2000] REMARK: EC Classification: Corrosive (causes burns) Eye Irritation SPECIES: Rabbit RESULT: Corrosive REFERENCE SOURCE: Atochem Paris la Defense (33) Report Consultox Laboratories Ltd. CL80 65 2030 (May 1980). [IUCLID 2000] REMARK: EC Classification: Irritating",,"JP_CHRIP, NZ_CCID, US_HSDB",3,CN(C)CCOC(=O)C(=C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J48.651E,J-GLOBAL,C=C(C)C(=O)OCCN(C)C,Train "JP_CHRIP: Cyclopentane","JP_CHRIP: Pentamethylene",287-92-3,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2044e.html,"JP_CHRIP: In a skin irritation test (OECD TG 404) with rabbits, no skin reaction (irritation score: 0.0) was observed, and it was determined that it was not irritating (SIDS (2010)). In addition, in a test with guinea pigs, there is a report that slight erythema was observed (Patty (2012), SIDS (2010)). From the above results, it was judged to be ""Not classified"" (Category 3 in UN GHS classification). Since the information described in the previous classification was absent from the Lists in the GHS classification guidance for the Japanese government, it was deleted, and test information according to any test guidelines was added, and the category was changed.",Provided,JP_CHRIP,1,C1CCCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.564J,J-GLOBAL,C1CCCC1,Train "AU_HCIS: imidazole JP_CHRIP: Imidazole NZ_CCID: Imidazole US_HSDB: Imidazole","AU_HCIS: 1H-Imidazole JP_CHRIP: 1,3-Diaza-2,4-cyclopentadiene 1,3-Diazole Glyoxaline Imidazole Miazole",288-32-4,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5703 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0012e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/62CEC8DD-C50A-4A76-8B08-68C06132EBDF US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8449","JP_CHRIP: In a test in which 0.5 mL of paste-like test substance containing 80% of this substance and water was applied to the rabbit skin for 4 hours, severe erythema developed overnight and persisted by day 8 after the observation period, slight necrosis appeared overnight, and necrosis in all layers was pathologically observed after the observation period. As a result, this substance was assessed to be corrosive (SIDS (2004)). Therefore, it was classified in Category 1. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"AU_HCIS, JP_CHRIP, NZ_CCID, US_HSDB",4,c1c[nH]cn1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.566F,J-GLOBAL,c1c[nH]cn1,Train "NZ_CCID: (9-Fluorenylmethyl) chloroformate",,28920-43-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4EC8D1DC-70AD-43BB-9828-8122F0EADF8B,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/34367,PubChem,O=C(Cl)OCC1c2ccccc2-c2ccccc21,Train "NZ_CCID: 1,2-Dihydroxy-3,4-cyclobutenedione","NZ_CCID: 3,4-dihydroxy-3-cyclobutene-1,2-dione",2892-51-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DAE4919D-DA08-4675-9F81-C07719F069A6,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1(=C(C(=O)C1=O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/17913,PubChem,O=c1c(O)c(O)c1=O,Train "EU_REACH: diethoxy(methyl){3-[(oxiran-2-yl)methoxy]propyl}silane",,2897-60-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17529/7/4/2/?documentUUID=bb5fc246-986c-4791-b454-b251d0cc1ef9,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](C)(CCCOCC1CO1)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/62467,PubChem,CCO[Si](C)(CCCOCC1CO1)OCC,Train "AU_HCIS: Phenol, 2-isononyl-4-methyl-",,28983-26-8,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6710,,,AU_HCIS,1,CC1=CC(=C(C=C1)O)CCCCCCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/120111,PubChem,Cc1ccc(O)c(CCCCCCC(C)C)c1,Train "EU_REACH: α,α-Dimethyl-ethyl ester benzeneacetic acid",,2901-13-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12374/7/4/2/?documentUUID=38ea4503-bc60-4716-8d18-f21b8ff4b12d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C(C)(C)C1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/232036,PubChem,CCOC(=O)C(C)(C)c1ccccc1,Train "NZ_CCID: 3,5-Dichlorobenzoyl chloride",,2905-62-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F29E76C4-E04A-4C76-A6AD-6B66EA348FF8,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=C(C=C(C=C1Cl)Cl)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/76191,PubChem,O=C(Cl)c1cc(Cl)cc(Cl)c1,Train "EU_REACH: 3-(propan-2-yloxy)propan-1-amine",,2906-12-9,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21379/7/4/2/?documentUUID=6a0557df-4947-4c14-8d22-c9f9b4018e9a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)OCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/76194,PubChem,CC(C)OCCCN,Train "EU_REACH: 1-(2-hydroxy-2-methylpropoxy)-2,2,6,6-tetramethylpiperidin-4-yl octadecanoate",,290822-07-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12417/7/4/2/?documentUUID=54cbbb6a-12a6-448b-b961-6271e8cdbdf4,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCCC(=O)OC1CC(N(C(C1)(C)C)OCC(C)(C)O)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/21885088,PubChem,CCCCCCCCCCCCCCCCCC(=O)OC1CC(C)(C)N(OCC(C)(C)O)C(C)(C)C1,Train "NZ_CCID: Chlorophenylacetyl chloride",,2912-62-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/830B5AA4-2870-4EE0-A1C2-F6B191269F9C,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)C(C(=O)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/102902,PubChem,O=C(Cl)C(Cl)c1ccccc1,Train "EU_REACH: biphenyl-4-carbonitrile",,2920-38-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20254/7/4/2/?documentUUID=fe7bbedb-9335-4fce-8d7c-4c7a24ad4b8b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C2=CC=C(C=C2)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/18021,PubChem,N#Cc1ccc(-c2ccccc2)cc1,Train "EU_REACH: (2-amino-1,3-thiazol-4-yl)acetic acid",,29676-71-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22991/7/4/2/?documentUUID=7e6c6021-8602-431a-835b-07d99aced2a5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(N=C(S1)N)CC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/34665,PubChem,Nc1nc(CC(=O)O)cs1,Train "EU_REACH: 2-bromo-5-hydroxy-4-methoxybenzaldehyde",,2973-59-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24229/7/4/2/?documentUUID=2ca6ec2b-52ae-4003-a639-9d611275a500,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=C(C=C(C(=C1)Br)C=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/616068,PubChem,COc1cc(Br)c(C=O)cc1O,Train "EU_REACH: 3-ethoxy-1,1,1,2,3,4,4,5,5,6,6,6-dodecafluoro-2-(trifluoromethyl)hexane",,297730-93-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21902/7/4/2/?documentUUID=83180d8a-21f8-4490-b100-1b6ff5dd48eb,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(C(C(F)(F)F)(C(F)(F)F)F)(C(C(C(F)(F)F)(F)F)(F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/2782436,PubChem,CCOC(F)(C(F)(F)C(F)(F)C(F)(F)F)C(F)(C(F)(F)F)C(F)(F)F,Train "JP_CHRIP: Dimethyl-p-nitrophenylthiophosphate; Methylparathion","JP_CHRIP: Dimethyl-p-nitrophenylthiophosphate Methyl parathion Methylparathion O,O-Dimethyl O-4-nitrophenyl phosphorothioate O,O-Dimethyl-p-nitrophenylthionophosphate Parathion-methyl Phosphorothioic acid, O,O-dimethyl O-(4-nitrophenyl) ester",298-00-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2046e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1) - (6). The classification result was changed due to new data obtained. [Evidence Data] (1) This substance (technical grade) did not irritate the skin and eye (EHC 145 (1993)). (2) As a result of 4-hour or 6-hour application of this substance to the rabbit skin at up to the lethal dose (LD100), no irritation was shown (EHC 145 (1993)). (3) It was not irritating in a skin irritation test with rabbits according to OECD TG 404 (EHC 145 (1993)). (4) It was slightly irritating to the skin in rabbits (JMPR (1995)). (5) In a skin irritation test with rabbits according to EPA OPPTS 870.2500, the maximum score was 2, and the score after 72 hours was 0.5 (EPA Pesticides (2006)). (6) This substance is not irritating to the skin and eye (GESTIS (Access on May 2020)). [Reference Data, etc.] (7) In a skin irritation test by 1 to 24-hour semi-occlusive application of a formulation containing 80% of this substance to the rabbit skin, very minor to moderate reddening was seen at 1 hour after the application (GESTIS (Access on May 2020)).",Provided,JP_CHRIP,1,COP(=S)(OC)Oc1ccc(cc1)[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.981E,J-GLOBAL,COP(=S)(OC)Oc1ccc([N+](=O)[O-])cc1,Train "JP_CHRIP: Bis(2-ethylhexyl) hydrogen phosphate NZ_CCID: Di(2-ethylhexyl)phosphate","JP_CHRIP: bis(2-ethylhexyl) hydrogen phosphate Bis(2-ethylhexyl)hydrogen phosphate Bis(2-ethylhexyl)orthophosphoric acid Bis(isooctyl)phosphate di(2-ethylhexyl) phosphate Di(2-ethylhexyl)phosphate Dioctylphosphate",298-07-7,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0092e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8EAD103D-96BC-4C0B-93B6-6439F764973D","JP_CHRIP: It was classified in Category 1 because it was corrosive in a skin irritation test in which 0.5 mL of this substance was applied to rabbits for 1-8 hours (USEPA/HPV (2001)), it was highly irritating and the primary dermal irritation index (PDII) was 6.2 in another test by a 24-hour occlusive application of 0.5 mL of undiluted this substance to rabbits (HPVIS (2009)). Besides, in tests with rabbits other than the above tests, it is also reported that PDII was 0, and it was not irritating after a 24-hour occlusive application of 0.5 mL, and PDII was 4.85, it was irritating but not corrosive after a 48-hour occlusive application (HPVIS (2009)). NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CCCCC(CC)COP(=O)(O)OCC(CC)CCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J34.641A,J-GLOBAL,CCCCC(CC)COP(=O)(O)OCC(CC)CCCC,Train "EU_REACH: 2-oxoacetic acid",,298-12-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14954/7/4/2/?documentUUID=b493d280-8df0-48d5-90dd-bce397a1446f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(=O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/760,PubChem,O=CC(=O)O,Train "EU_REACH: 1-(2-butoxy-1-methylethoxy)propan-2-ol JP_CHRIP: Dipropylene glycol butyl ether","JP_CHRIP: Dipropylene glycol-n-butyl ether DPGnBE n-Butoxy-methylethoxy-propanol n-Butoxy-propoxy-propanol",29911-28-2,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14152/7/4/2/?documentUUID=d89cf177-0f95-4fe4-9134-27c9c0f7e0aa JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-0006e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: It was classified as ""Not classified"" because there was no irritation in a skin irritation test with rabbits (SIDS (2005)).",Provided,"EU_REACH, JP_CHRIP",2,CCCCOCC(C)OCC(C)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J50.956F,J-GLOBAL,CCCCOCC(C)OCC(C)O,Train "EU_REACH: dimethyl 5-({2-oxo-1-[(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)carbamoyl]propyl}diazenyl)isophthalate",,29920-31-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10984/7/4/2/?documentUUID=28f34200-1e34-4186-b472-1631620184b7,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC2=C(C=C1)NC(=O)N2)N=NC3=CC(=CC(=C3)C(=O)OC)C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/121754,PubChem,COC(=O)c1cc(N=NC(C(C)=O)C(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)cc(C(=O)OC)c1,Train "EU_REACH: ethyl 4-oxopiperidine-1-carboxylate",,29976-53-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21330/7/4/2/?documentUUID=2aadac35-b431-48c7-ad3e-46c81adc2b8b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)N1CCC(=O)CC1,https://pubchem.ncbi.nlm.nih.gov/compound/34767,PubChem,CCOC(=O)N1CCC(=O)CC1,Train "AU_HCIS: Phenol, dioctyl-",,29988-16-7,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5807,,,AU_HCIS,1,CCCCCCCCC1=C(C(=CC=C1)O)CCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/121608,PubChem,CCCCCCCCc1cccc(O)c1CCCCCCCC,Train "NZ_CCID: 1,5-Diazabicyclo(4.3.0)non-5-ene","NZ_CCID: 1,5-diazabicyclo[4.3.0]non-5-ene",3001-72-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C5B1E1AC-9C9D-40B1-9841-E9DDB1E04F7A,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CC2=NCCCN2C1,https://pubchem.ncbi.nlm.nih.gov/compound/76349,PubChem,C1CN=C2CCCN2C1,Train "NZ_CCID: N,N-Dimethyldodecanamide","NZ_CCID: Dodecanamide, N,N-dimethyl-",3007-53-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/33B022C3-FE19-479C-86B2-1D2AF6469797,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCCCCCCCC(=O)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/18159,PubChem,CCCCCCCCCCCC(=O)N(C)C,Train "NZ_CCID: 3-Hydroxybutyric acid",,300-85-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CA25911F-46FA-4837-A2A2-324125EBDB30,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(CC(=O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/441,PubChem,CC(O)CC(=O)O,Train "JP_CHRIP: Oleamide","JP_CHRIP: (9Z)-9-Octadecenamide cis-9-Octadecenamide Oleamide oleamide (synonym:oleic acid amide) oleic acid amide Oleylamide",301-02-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0144e.html,"JP_CHRIP: In the rabbit test (OECD TG404), the result of ""not irritating"" was reported (IUCLID (2000)). In other rabbit test (GLP-compliant), 4-hour application of undiluted substance caused no irritation (IUCLID (2000)). Based on these documents, the substance was classified as ""Not classified"".",Provided,JP_CHRIP,1,CCCCCCCC/C=C\CCCCCCCC(=O)N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J36.613G,J-GLOBAL,CCCCCCCC/C=C\CCCCCCCC(N)=O,Train "AU_HCIS: Phenol, 2-methyl-4,6-dinonyl-",,3011-61-8,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5791,,,AU_HCIS,1,CCCCCCCCCC1=CC(=C(C(=C1)C)O)CCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/76383,PubChem,CCCCCCCCCc1cc(C)c(O)c(CCCCCCCCC)c1,Train "EU_REACH: hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate",,302776-68-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29413/7/4/2/?documentUUID=83541961-9212-4e36-b089-f60da40f54d0,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCOC(=O)C1=CC=CC=C1C(=O)C2=C(C=C(C=C2)N(CC)CC)O,https://pubchem.ncbi.nlm.nih.gov/compound/10111431,PubChem,CCCCCCOC(=O)c1ccccc1C(=O)c1ccc(N(CC)CC)cc1O,Train "NZ_CCID: 1,2-Ethanediamine, N-[2-(dimethylamino)ethyl]-N,N',N'-trimethyl-","NZ_CCID: 1,1,4,7,7-Pentamethyldiethylenetriamine, Diethylenetriamine, 1,1,4,7,7-pentamethyl-, PMDT, Pentamethyldiethylenetriamine",3030-47-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1DE3FF7D-8DD3-4413-906B-A0FAE0DACC7C,,,NZ_CCID,1,CN(C)CCN(C)CCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/18196,PubChem,CN(C)CCN(C)CCN(C)C,Train "EU_REACH: 4-{4-[difluoro(3,4,5-trifluorophenoxy)methyl]-3,5-difluorophenyl}-3-fluoro-4'-propyl-1,1'-biphenyl",,303186-36-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24181/7/4/2/?documentUUID=da8c4a98-d7fe-45c0-80be-257d4a8c4ea3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1=CC=C(C=C1)C2=CC(=C(C=C2)C3=CC(=C(C(=C3)F)C(OC4=CC(=C(C(=C4)F)F)F)(F)F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/59856380,PubChem,CCCc1ccc(-c2ccc(-c3cc(F)c(C(F)(F)Oc4cc(F)c(F)c(F)c4)c(F)c3)c(F)c2)cc1,Train "EU_REACH: {2-[2-(dimethylamino)ethoxy]ethyl}dimethylamine JP_CHRIP: Ethanamine, 2,2'-oxybis[N,N-dimethyl- NZ_CCID: Bis(2-(dimethylamino)ethyl) ether","JP_CHRIP: Bis(2-dimethylaminoethyl) ether N,N,N',N'-Tetramethyl-2,2'-oxybis(ethylamine) NZ_CCID: Bis(2-dimethylaminoethyl) ether, Bis(2-dimethylaminoethyl)ether",3033-62-3,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13873/7/4/2/?documentUUID=eb184b71-37c0-4bd2-b79c-433ffc676e4d JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0894e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/972B920A-FDFC-4E5E-94CD-66DD334413C9","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: From description that necrosis was accepted by the test applied to the rabbit skin (ACGIH (7th, 2001)), it was judged that there was caustic, and it was set as Category 1A-1C. NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",Provided,"EU_REACH, JP_CHRIP, NZ_CCID",3,CN(C)CCOCCN(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J12.980A,J-GLOBAL,CN(C)CCOCCN(C)C,Train "EU_REACH: 2-methylheptadecanoic acid",,30399-84-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13713/7/4/2/?documentUUID=c2d776d1-1afe-454e-9f6f-1e1489ddb675,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCCCCCCCCCCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/21859,PubChem,CC(C)CCCCCCCCCCCCCCC(=O)O,Train "EU_REACH: ethyl 2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]benzoate",,304435-84-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19791/7/4/2/?documentUUID=ca4a442b-e4ad-4b32-bd57-af081c821a9c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC1=C(C=C(C=C1)S(=O)(=O)N2CCN(CC2)C)C(=O)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/22052241,PubChem,CCOC(=O)c1cc(S(=O)(=O)N2CCN(C)CC2)ccc1OCC,Train "EU_REACH: p-[(5-cyano-1,6-dihydro-2-hydroxy-1,4-dimethyl-6-oxo-3-pyridyl)azo]-N-(2-ethylhexyl)benzamide",,30449-81-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21061/7/4/2/?documentUUID=3ddd1ff1-26bb-49e8-8fa4-2d194fa1fff9,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)CNC(=O)C1=CC=C(C=C1)N=NC2=C(C(=C(N(C2=O)C)O)C#N)C,https://pubchem.ncbi.nlm.nih.gov/compound/121713,PubChem,CCCCC(CC)CNC(=O)c1ccc(N=Nc2c(C)c(C#N)c(O)n(C)c2=O)cc1,Train "EU_REACH: octadecafluoro-decahydronaphthalene",,306-94-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25306/7/4/2/?documentUUID=65827910-d3ec-4784-bdf1-e5b816940368,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C12(C(C(C(C(C1(F)F)(F)F)(F)F)(F)F)(C(C(C(C2(F)F)(F)F)(F)F)(F)F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/9386,PubChem,FC1(F)C(F)(F)C(F)(F)C2(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C2(F)C1(F)F,Train "US_HSDB: Perfluorohexanoic acid",,307-24-4,Cat 1,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8299,,,US_HSDB,1,C(=O)(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)O,https://pubchem.ncbi.nlm.nih.gov/compound/67542,PubChem,O=C(O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train "EU_REACH: (1R,2S,3S,6R,7S)-tricyclo[5.2.1.0²,⁶]decane-3-carbaldehyde; bis((1R,2S,4R,6R,7S)-tricyclo[5.2.1.0²,⁶]decane-4-carbaldehyde)",,30772-79-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17510/7/4/2/?documentUUID=3b0d87bb-8f1c-486a-891b-043b451f144f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,O=CC1CCC2C3CCC(C3)C12,https://cactus.nci.nih.gov/chemical/structure/30772-79-3/smiles,CACTUS,O=CC1CCC2C3CCC(C3)C12,Train "EU_REACH: N1,N4-bis(5-methylhexan-2-yl)benzene-1,4-diamine",,3081-14-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13514/7/4/2/?documentUUID=5aa00b2e-0c8e-4804-b487-208329f50bb7,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCC(C)NC1=CC=C(C=C1)NC(C)CCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/18320,PubChem,CC(C)CCC(C)Nc1ccc(NC(C)CCC(C)C)cc1,Train "EU_REACH: 2,9-dichloro-5,7,12,14-tetrahydro-5,12-diazapentacene-7,14-dione",,3089-17-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14471/7/4/2/?documentUUID=fb5f5603-0eae-479c-a577-140dc15c671c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC2=C(C=C1Cl)C(=O)C3=CC4=C(C=C3N2)C(=O)C5=C(N4)C=CC(=C5)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/76530,PubChem,O=c1c2cc(Cl)ccc2[nH]c2cc3c(=O)c4cc(Cl)ccc4[nH]c3cc12,Train "EU_REACH: tris{2-[2-(2-methoxyethoxy)ethoxy]ethyl} borate",,30989-05-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14522/7/4/2/?documentUUID=df2fe914-a533-45e4-9f45-bc67e178576f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,B(OCCOCCOCCOC)(OCCOCCOCCOC)OCCOCCOCCOC,https://pubchem.ncbi.nlm.nih.gov/compound/14402222,PubChem,COCCOCCOCCOB(OCCOCCOCCOC)OCCOCCOCCOC,Train "EU_REACH: tris({[1,1'-biphenyl]-4-yl})-1,3,5-triazine",,31274-51-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13874/7/4/2/?documentUUID=2ba5b8aa-d8f8-41cb-beb7-b23c988aca5c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C2=CC=C(C=C2)C3=NC(=NC(=N3)C4=CC=C(C=C4)C5=CC=CC=C5)C6=CC=C(C=C6)C7=CC=CC=C7,https://pubchem.ncbi.nlm.nih.gov/compound/11628027,PubChem,c1ccc(-c2ccc(-c3nc(-c4ccc(-c5ccccc5)cc4)nc(-c4ccc(-c5ccccc5)cc4)n3)cc2)cc1,Train "EU_REACH: 9-Anthracenecarboxylic acid, (triethoxysilyl)methyl ester",,313482-99-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31796/7/4/2/?documentUUID=4496a07b-03dd-4025-93c6-d3acf13e19bb,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](COC(=O)C1=C2C=CC=CC2=CC3=CC=CC=C31)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/12991882,PubChem,CCO[Si](COC(=O)c1c2ccccc2cc2ccccc12)(OCC)OCC,Train "EU_REACH: 5-bromo-3-sec-butyl-6-methylpyrimidine-2,4(1H,3H)-dione JP_CHRIP: 5-Bromo-3-sec-butyl-6-methyl uracil; Bromacil","JP_CHRIP: 2,4(1H,3H)-Pyrimidinedione, 5-bromo-6-methyl-3-(1-methyl propyl)- 5-Bromo-3-sec-butyl-6-methyl uracil 5-Bromo-3-sec-butyl-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione 5-Bromo-6-methyl-3-(1-methylpropyl) uracil 5-Bromo-6-methyl-3-(1-methylpropyl)-2,4(1H,3H)-pyrimidinedione Bromacil",314-40-9,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26639/7/4/2/?documentUUID=84e63bb9-601e-4306-acd9-c5be8eb0d34b JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2104e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" (corresponding to Category 3 in UN GHS classification) from (1) - (3). [Evidence Data] (1) It was reported to be not irritating in a skin irritation test with rabbits according to OECD TG 404 (REACH registration dossier (Access on September 2020)). (2) In a skin irritation test with rabbits according to EPA OPP 81-5, the primary irritation score was 0.8, and it was classified in Category IV (no irritation or slight erythema seen at 72 hours after application) (EPA Pesticides RED (1996)). (3) In a skin irritation test with rabbits, no irritation was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2016)).",Provided,"EU_REACH, JP_CHRIP",2,CCC(C)n1c(=O)[nH]c(C)c(Br)c1=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J8.594D,J-GLOBAL,CCC(C)n1c(=O)[nH]c(C)c(Br)c1=O,Train "NZ_CCID: (1S)-(+)-Camphor-10-sulphonic acid",,3144-16-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/912701A9-9463-43E4-9AA8-28F84F53D953,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC1([C@@H]2CC[C@]1(C(=O)C2)CS(=O)(=O)O)C,https://pubchem.ncbi.nlm.nih.gov/compound/65617,PubChem,CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)O)C(=O)C2,Train "NZ_CCID: Cyclohexyl isocyanate",,3173-53-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F4F233DB-0143-4268-BBD9-84D5455688A4,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CCC(CC1)N=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/18502,PubChem,O=C=NC1CCCCC1,Train "EU_REACH: 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-methoxyphenyl)-3-oxobutyramide]",,31775-16-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17245/7/4/2/?documentUUID=52d8c8bd-3455-4f21-b26c-a893c49d854a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC=C(C=C1)OC)N=NC2=C(C=C(C=C2)C3=CC(=C(C=C3)N=NC(C(=O)C)C(=O)NC4=CC=C(C=C4)OC)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/169359,PubChem,COc1ccc(NC(=O)C(N=Nc2ccc(-c3ccc(N=NC(C(C)=O)C(=O)Nc4ccc(OC)cc4)c(Cl)c3)cc2Cl)C(C)=O)cc1,Train "EU_REACH: 2,2'-[(3,3'-dichlorobiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis[N-(4-ethoxyphenyl)-3-oxobutanamide]",,31775-20-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11673/7/4/2/?documentUUID=16203664-2625-4b97-8d81-727ad79db938,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC1=CC=C(C=C1)NC(=O)C(C(=O)C)N=NC2=C(C=C(C=C2)C3=CC(=C(C=C3)N=NC(C(=O)C)C(=O)NC4=CC=C(C=C4)OCC)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/169360,PubChem,CCOc1ccc(NC(=O)C(N=Nc2ccc(-c3ccc(N=NC(C(C)=O)C(=O)Nc4ccc(OCC)cc4)c(Cl)c3)cc2Cl)C(C)=O)cc1,Train "EU_REACH: butyl 2-({2-hydroxy-3-[(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)carbamoyl]-1-naphthyl}diazenyl)benzoate",,31778-10-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15921/7/4/2/?documentUUID=46ddc12b-51f5-48cf-999d-3ace11c9e9d9,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOC(=O)C1=CC=CC=C1N=NC2=C(C(=CC3=CC=CC=C32)C(=O)NC4=CC5=C(C=C4)NC(=O)N5)O,https://pubchem.ncbi.nlm.nih.gov/compound/161725,PubChem,CCCCOC(=O)c1ccccc1N=Nc1c(O)c(C(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)cc2ccccc12,Train "NZ_CCID: 3-(Dimethylamino)-1-propanol",,3179-63-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DF0B869C-AC8E-49BD-A6F1-74783CB78064,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CN(C)CCCO,https://pubchem.ncbi.nlm.nih.gov/compound/76646,PubChem,CN(C)CCCO,Train "AU_HCIS: Dodecanamide, N-[3-(dimethylamino)propyl]-",,3179-80-4,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6761,,,AU_HCIS,1,CCCCCCCCCCCC(=O)NCCCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/51392,PubChem,CCCCCCCCCCCC(=O)NCCCN(C)C,Train "EU_REACH: methyl 2-amino-5-fluorobenzoate",,319-24-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11929/7/4/2/?documentUUID=2da207b3-c3ff-4798-bff3-cc6bab66315e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1=C(C=CC(=C1)F)N,https://pubchem.ncbi.nlm.nih.gov/compound/2783401,PubChem,COC(=O)c1cc(F)ccc1N,Train "EU_REACH: (2S,3R,4S,5S,6R)-5-(benzoyloxy)-6-[(benzoyloxy)methyl]-4-{[(2S)-1-(benzyloxy)-3-cyclohexyl-1-oxopropan-2-yl]oxy}-2-(ethylsulfanyl)oxan-3-yl benzoate",,322761-81-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17923/7/4/2/?documentUUID=8433ebcf-63ba-4045-b91e-216185585edc,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCS[C@H]1[C@@H]([C@H]([C@H]([C@H](O1)COC(=O)C2=CC=CC=C2)OC(=O)C3=CC=CC=C3)O[C@@H](CC4CCCCC4)C(=O)OCC5=CC=CC=C5)OC(=O)C6=CC=CC=C6,https://pubchem.ncbi.nlm.nih.gov/compound/101058569,PubChem,CCS[C@@H]1O[C@H](COC(=O)c2ccccc2)[C@H](OC(=O)c2ccccc2)[C@H](O[C@@H](CC2CCCCC2)C(=O)OCc2ccccc2)[C@H]1OC(=O)c1ccccc1,Train "JP_CHRIP: 4-Isopropyl-3-methylphenol",,3228-02-2,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0004e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 72-hour observation), no skin irritation was seen (erythema/eschar score: 0/0/0, edema score: 0/0/0) (NICNAS IMAP (2016), REACH registration dossier (Accessed May 2020)). [Reference Data, etc.] (2) It is reported that in a skin irritation test with rabbits (n = 8) (semi-occlusive, 4-hour application, 72-hour observation), no erythema or edema was found in either an abraded skin group (4 animals) or an intact skin group (4 animals) at either 0.1% solution or 1% solution applied (NICNAS IMAP (2016)).",Provided,JP_CHRIP,1,CC(C)c1ccc(O)cc1C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J30.641J,J-GLOBAL,Cc1cc(O)ccc1C(C)C,Train "EU_REACH: 4-ethoxy-2,3-difluoro-4'-[(1s,4r)-4-ethylcyclohexyl]-1,1'-biphenyl",,323178-01-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24085/7/4/2/?documentUUID=0553804d-cd01-4a81-bd79-891eae2bd53f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1CCC(CC1)C2=CC=C(C=C2)C3=C(C(=C(C=C3)OCC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/58997815,PubChem,CCOc1ccc(-c2ccc(C3CCC(CC)CC3)cc2)c(F)c1F,Train "EU_REACH: (3S,5S)-5-[(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl]-3-(propan-2-yl)oxolan-2-one",,324763-46-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5295/7/4/2/?documentUUID=aa358301-705c-44d2-8e2b-76191c77d85e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)[C@@H]1C[C@H](OC1=O)[C@H](C[C@H](CC2=CC(=C(C=C2)OC)OCCCOC)C(C)C)N=[N+]=[N-],https://pubchem.ncbi.nlm.nih.gov/compound/11775573,PubChem,COCCCOc1cc(C[C@@H](C[C@H](N=[N+]=[N-])[C@@H]2C[C@@H](C(C)C)C(=O)O2)C(C)C)ccc1OC,Train "EU_REACH: 3-amino-2,2-dimethylpropanamide",,324763-51-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19104/7/4/2/?documentUUID=95990132-6b45-42fc-9985-54305e7f9f45,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(CN)C(=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/11159315,PubChem,CC(C)(CN)C(N)=O,Train "EU_REACH: 2-tetradecyloctadecan-1-ol",,32582-32-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12081/7/4/2/?documentUUID=90362e6a-1883-44dd-aec3-1f175fe06d10,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCC(CCCCCCCCCCCCCC)CO,https://pubchem.ncbi.nlm.nih.gov/compound/94435,PubChem,CCCCCCCCCCCCCCCCC(CO)CCCCCCCCCCCCCC,Train "EU_REACH: 4'-ethyl-3-fluoro-4-(3,4,5-trifluorophenyl)-1,1'-biphenyl",,326894-55-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30439/7/4/2/?documentUUID=edae4d50-97f9-416a-b646-61f5b03895e4,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1=CC=C(C=C1)C2=CC(=C(C=C2)C3=CC(=C(C(=C3)F)F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/12010663,PubChem,CCc1ccc(-c2ccc(-c3cc(F)c(F)c(F)c3)c(F)c2)cc1,Train "EU_REACH: 1,1,3,3-tetramethyldisiloxane",,3277-26-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14225/7/4/2/?documentUUID=d65d74a2-8d43-4558-845c-a9810cc4f95a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](C)O[Si](C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6327482,PubChem,C[Si](C)O[Si](C)C,Train "EU_REACH: 2-(2-methylbutan-2-yl)phenol",,3279-27-4,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17108/7/4/2/?documentUUID=628910cd-0e61-4f39-b56c-78250004ffba,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C)(C)C1=CC=CC=C1O,https://pubchem.ncbi.nlm.nih.gov/compound/76769,PubChem,CCC(C)(C)c1ccccc1O,Train "NZ_CCID: Methyl 4-chloroacetoacetate",,32807-28-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7BD3F552-461A-49B9-A8B7-DED873FECB86,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,COC(=O)CC(=O)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/36240,PubChem,COC(=O)CC(=O)CCl,Train "JP_CHRIP: 2,2-Dimethylpropanoyl chloride NZ_CCID: Pivaloyl chloride","JP_CHRIP: Pivaloyl chloride",3282-30-2,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0095e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5037F815-1BC7-4009-83E5-2088A00F3727","JP_CHRIP: In a test semi-occlusive applied 0.5 mL of undiluted this substance to six rabbit skins for 4 hours (GLP compliance), erythema and edema were observed until 21 days after application, a maximum irritation score was 7.0/8.0, necrosis was present on the application sites in all six animals, and this substance was assessed as corrosive. (SIDS (2011)) Therefore it was classified in Category 1. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CC(C)(C)C(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J33.810I,J-GLOBAL,CC(C)(C)C(=O)Cl,Train "EU_REACH: (acetyloxy)(methyl)(propan-2-yloxy)silyl acetate",,329039-38-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8884/7/4/2/?documentUUID=82be1ab5-8333-4dde-b45c-6a89b08f0759,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)O[Si](C)(OC(=O)C)OC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/23344072,PubChem,CC(=O)O[Si](C)(OC(C)=O)OC(C)C,Train "NZ_CCID: Phenylmethanesulphonyl fluoride",,329-98-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/337271B3-D0D4-4021-BEE4-CB3195DFC99E,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)CS(=O)(=O)F,https://pubchem.ncbi.nlm.nih.gov/compound/4784,PubChem,O=S(=O)(F)Cc1ccccc1,Train "EU_REACH: 2,2-bis({[(3-sulfanylpropanoyl)oxy]methyl})butyl 3-sulfanylpropanoate",,33007-83-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25116/7/4/2/?documentUUID=11404f50-6d11-4827-a803-887712bfd13e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(COC(=O)CCS)(COC(=O)CCS)COC(=O)CCS,https://pubchem.ncbi.nlm.nih.gov/compound/118379,PubChem,CCC(COC(=O)CCS)(COC(=O)CCS)COC(=O)CCS,Train "EU_REACH: 3-phenyl-5-(thiophen-2-yl)-1,2,4-oxadiazole",,330459-31-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16543/7/4/2/?documentUUID=57402669-bea4-4d23-a970-8c4dbf7d712a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C2=NOC(=N2)C3=CC=CS3,https://pubchem.ncbi.nlm.nih.gov/compound/695679,PubChem,c1ccc(-c2noc(-c3cccs3)n2)cc1,Train "JP_CHRIP: 3-(3,4-Dichlorophenyl)-1,1-dimethylurea; Diuron","JP_CHRIP: N-(3,4-dichlorophenyl)-N',N'-dimethylurea",330-54-1,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2066e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1) - (3). The classification result was changed due to new data (1) - (3) obtained. [Evidence Data] (1) In a skin irritation test with rabbits according to EPA OPPTS 870.2500, all irritation reactions cleared by 72 hours (EPA Pesticides RED (2003)). (2) In an irritation test on the forearms of human volunteers, no irritation was seen (GESTIS (Access on May 2020)). (3) In a skin irritation test with rabbits according to OECD TG 404, the mean score at 24/48/72 hours after application was all 0 (REACH registration dossier (Access on September 2020)). [Reference Data, etc.] (4) This substance may irritate the skin and eye in humans (ACGIH (7th, 2001), HSDB (Access on May 2020)). (5) In a skin irritation test with rabbits by 24-hour application, it was irritating (GESTIS (Access on May 2020)). (6) In a skin irritation test in which 50% paste (0.05 g) of this substance was applied to the guinea pig skin, it was slightly irritating (Agricultural Chemicals Times supplement ""Agricultural chemicals technology information"" No. 8 (Japan Crop Protection Association, 1991)).",Provided,JP_CHRIP,1,CN(C)C(=O)Nc1ccc(Cl)c(Cl)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J30.227I,J-GLOBAL,CN(C)C(=O)Nc1ccc(Cl)c(Cl)c1,Train "EU_REACH: 2-[1-(2-hydroxy-3,5-dimethylphenyl)-2-methylpropyl]-4,6-dimethylphenol",,33145-10-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22036/7/4/2/?documentUUID=ac47212e-6b84-4f9a-81a0-7190958e241e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C(=C1)C(C2=CC(=CC(=C2O)C)C)C(C)C)O)C,https://pubchem.ncbi.nlm.nih.gov/compound/94446,PubChem,Cc1cc(C)c(O)c(C(c2cc(C)cc(C)c2O)C(C)C)c1,Train "NZ_CCID: 4-Nitrocatechol",,3316-09-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9A6F33F9-0AE3-46CD-B3FA-8301C02DA9D6,"NZ_CCID: Skin Irritation R PHRASE: R 35 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC(=C(C=C1[N+](=O)[O-])O)O,https://pubchem.ncbi.nlm.nih.gov/compound/3505109,PubChem,O=[N+]([O-])c1ccc(O)c(O)c1,Train "NZ_CCID: Methyl trifluoromethanesulphonate","NZ_CCID: Methyl triflate",333-27-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/21D47FB0-6821-49E0-9F0A-CD2893817B84,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,COS(=O)(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/9526,PubChem,COS(=O)(=O)C(F)(F)F,Train "JP_CHRIP: 2,3-dicyano-1,4-dithiaanthraquinone; Dithianon","JP_CHRIP: 2,3-dicyano-1,4-dithia-anthraquinone [synonym:Dithianon] 2,3-Dicyano-1,4-dithiaanthraquinone 5,10-dioxo-5,10-dihydronaphtho[2,3-b][1,4]dithiine-2,3-dicarbonitrile (synonym:2,3-dicyano-1,4-dithia-anthraquinone or dithianon)",3347-22-6,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2072e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1) - (4). [Evidence Data] (1) In a skin irritation test with rabbits on this substance according to OECD TG 404 (4-hour occlusive application), it was not irritating (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). (2) This substance was not irritating in a skin irritation test with rabbits (4-hour occlusive application) (JMPR (2010)). (3) This substance was not irritating to the rabbit skin (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018)). (4) This substance was not irritating in a skin irritation test with rabbits (24-hour occlusive application) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012), Agricultural Chemicals Times supplement ""Agricultural chemicals technology information"" No. 9 (Japan Crop Protection Association, 1991)). [Reference Data, etc.] (5) This substance may cause severe skin irritation in sensitive individuals (HSDB (Access on May 2020)).",Provided,JP_CHRIP,1,O=c1c2ccccc2c(=O)c2=c1sc(c(s2)C#N)C#N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.516K,J-GLOBAL,N#Cc1sc2c(=O)c3ccccc3c(=O)c=2sc1C#N,Train "EU_REACH: 1,1,2,2,3,3,4,5,5,6-decafluoro-4,6-bis(trifluoromethyl)cyclohexane",,335-27-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18928/7/4/2/?documentUUID=5cddc74c-bc1f-4288-850b-80fcd5e886e6,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1(C(C(C(C(C1(F)F)(F)F)(F)F)(C(F)(F)F)F)(F)F)(C(F)(F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/78975,PubChem,FC(F)(F)C1(F)C(F)(F)C(F)(F)C(F)(F)C(F)(C(F)(F)F)C1(F)F,Train "NZ_CCID: Bis(heptafluorobutyric) anhydride","NZ_CCID: heptafluorobutyric anhydride",336-59-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A47FC683-37C2-496E-B473-91341AA8AB3F,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(=O)(C(C(C(F)(F)F)(F)F)(F)F)OC(=O)C(C(C(F)(F)F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/67643,PubChem,O=C(OC(=O)C(F)(F)C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)C(F)(F)F,Train "EU_REACH: Methyl (2S,3R)-2-amino-3-hydroxy-butanoate",,3373-59-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32138/7/4/2/?documentUUID=d43404b4-e277-401a-8d55-8230391f98f7,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@H]([C@@H](C(=O)OC)N)O,https://pubchem.ncbi.nlm.nih.gov/compound/2734894,PubChem,COC(=O)[C@@H](N)[C@@H](C)O,Train "NZ_CCID: Benzenemethanamine, N-(1,1-dimethylethyl)-","NZ_CCID: N-(tert-butyl)benzylamine, N-Benzyl-tert-butylamine",3378-72-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/571DAD77-804D-4A7B-932B-621A617AD99F,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)(C)NCC1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/76908,PubChem,CC(C)(C)NCc1ccccc1,Train "EU_REACH: 5-chloro-2-(4-chlorophenoxy)phenol",,3380-30-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12528/7/4/2/?documentUUID=a5cd10ab-a44b-4ede-946e-9dcd350bfd82,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1OC2=C(C=C(C=C2)Cl)O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/18807,PubChem,Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1,Train "EU_REACH: 2-chloro-1,1-difluoroethane",,338-65-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12121/7/4/2/?documentUUID=eb9a6452-2954-49c6-aeae-3d37b1fa5eaa,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(C(F)F)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/2736499,PubChem,FC(F)CCl,Train "EU_REACH: 4-methyl-2,2,4,6,6-pentaphenyl-3,5-dioxa-2,4,6-trisilaheptane",,3390-61-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24084/7/4/2/?documentUUID=dc889756-e737-46ef-ab03-614687e1a6d5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](C1=CC=CC=C1)(C2=CC=CC=C2)O[Si](C)(C3=CC=CC=C3)O[Si](C)(C4=CC=CC=C4)C5=CC=CC=C5,https://pubchem.ncbi.nlm.nih.gov/compound/76925,PubChem,C[Si](O[Si](C)(c1ccccc1)c1ccccc1)(O[Si](C)(c1ccccc1)c1ccccc1)c1ccccc1,Train "EU_REACH: 1H-benzo[10,5]anthra[2,1,9-def]isoquinoline-1,3(2H)-dione",,33955-44-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7530/7/4/2/?documentUUID=a59cfc9d-3d32-4c7c-87ce-316d7ecd2a8f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC2=C3C(=C1)C4=C5C(=CC=C6C5=C(C=C4)C(=O)NC6=O)C3=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/11759047,PubChem,O=C1NC(=O)c2ccc3c4cccc5cccc(c6ccc1c2c63)c54,Train "EU_REACH: endo-8-isopropyl-8-azabicyclo[3.2.1]octan-3-ol",,3423-25-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7959/7/4/2/?documentUUID=5142dcef-74fa-494f-a5b9-a9d54ad5ddb0,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)N1C2CCC1CC(C2)O,https://pubchem.ncbi.nlm.nih.gov/compound/103007,PubChem,CC(C)N1C2CCC1CC(O)C2,Train "EU_REACH: 8-isopropyl-8-azabicyclo[3.2.1]octan-3-one",,3423-28-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8201/7/4/2/?documentUUID=211d17d9-07f8-4292-975b-e8e95ca8d2d4,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)N1C2CCC1CC(=O)C2,https://pubchem.ncbi.nlm.nih.gov/compound/103009,PubChem,CC(C)N1C2CCC1CC(=O)C2,Train "EU_REACH: 2-methylbutane-2-peroxol",,3425-61-4,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5881/7/4/2/?documentUUID=2ac43cd2-557f-4351-b8b7-92e42879a792,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C)(C)OO,https://pubchem.ncbi.nlm.nih.gov/compound/76962,PubChem,CCC(C)(C)OO,Train "NZ_CCID: 2-Bromobenzyl bromide",,3433-80-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2F04F47D-878A-446A-978E-52D1DFEDF166,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)CBr)Br,https://pubchem.ncbi.nlm.nih.gov/compound/76965,PubChem,BrCc1ccccc1Br,Train "EU_REACH: Octadecanamide, N-[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl]-",,34354-88-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24105/7/4/2/?documentUUID=07fe97f5-567e-499a-ad8a-713ddc6ebc08,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@@H]([C@@H](CCCCCCCCCCCCCC)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/9898642,PubChem,CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC,Train "EU_REACH: 2-methylpropanoyl 2-methylpropaneperoxoate",,3437-84-1,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11632/7/4/2/?documentUUID=19fd82bb-83ae-46ab-af44-ce1c89ab6284,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C(=O)OOC(=O)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/76969,PubChem,CC(C)C(=O)OOC(=O)C(C)C,Train "EU_REACH: 1,1,2,2,3,3,4,4,4-nonafluoro-N-(2-hydroxyethyl)-N-methylbutane-1-sulfonamide",,34454-97-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5299/7/4/2/?documentUUID=40bc5d99-f010-41fd-971e-0e1579669ae2,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(CCO)S(=O)(=O)C(C(C(C(F)(F)F)(F)F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/118688,PubChem,CN(CCO)S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train "EU_REACH: 1,1,2,2,3,3,4,4,4-nonafluoro-N,N-bis(2-hydroxyethyl)butane-1-sulfonamide",,34455-00-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27023/7/4/2/?documentUUID=7417842f-6f35-4819-96fd-cc2c220e6055,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CO)N(CCO)S(=O)(=O)C(C(C(C(F)(F)F)(F)F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/118689,PubChem,O=S(=O)(N(CCO)CCO)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train "EU_REACH: N-(carboxymethyl)-N,N-dimethyl-3-{[(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)sulfonyl]amino}propan-1-aminium hydroxide",,34455-29-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17549/7/4/2/?documentUUID=24640f75-c8c1-4a68-8e83-69e4ca8f5d67,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[N+](C)(CCCNS(=O)(=O)CCC(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)CC(=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/118691,PubChem,C[N+](C)(CCCNS(=O)(=O)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)CC(=O)[O-],Train "EU_REACH: 2,5-anhydro-4-{[4-(4-{4-[({1-[(2S,3S)-2-(benzyloxy)pentan-3-yl]hydrazino}carbonyl)amino]phenyl}piperazin1-yl)phenoxy]methyl}-1,3,4-trideoxy-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-",,345217-03-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18670/7/4/2/?documentUUID=4c164cfe-3ebc-426b-9dc7-7af92362d490,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC[C@@H]([C@H](C)OCC1=CC=CC=C1)N(C(=O)NC2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@H]5C[C@](OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F)N,https://pubchem.ncbi.nlm.nih.gov/compound/165364850,PubChem,CC[C@@H]([C@H](C)OCc1ccccc1)N(N)C(=O)Nc1ccc(N2CCN(c3ccc(OC[C@@H]4CO[C@@](Cn5cncn5)(c5ccc(F)cc5F)C4)cc3)CC2)cc1,Train "NZ_CCID: 2-Fluorobenzyl chloride",,345-35-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B9A1C874-1106-49B9-AF9E-98AA441BF8CB,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)CCl)F,https://pubchem.ncbi.nlm.nih.gov/compound/9580,PubChem,Fc1ccccc1CCl,Train "EU_REACH: N-(2,5-dimethoxyphenyl)acetamide",,3467-59-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5639/7/4/2/?documentUUID=b690b860-1db5-42be-bd36-4333ed4cfd8d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)NC1=C(C=CC(=C1)OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/77015,PubChem,COc1ccc(OC)c(NC(C)=O)c1,Train "NZ_CCID: Boron tris (trifluoroacetate)",,350-70-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/336E57B3-477A-4A8E-9B92-C9045F80ABCE,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,B(OC(=O)C(F)(F)F)(OC(=O)C(F)(F)F)OC(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/67693,PubChem,O=C(OB(OC(=O)C(F)(F)F)OC(=O)C(F)(F)F)C(F)(F)F,Train "EU_REACH: 1-[4-(benzyloxy)phenyl]-2-bromopropan-1-one",,35081-45-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20724/7/4/2/?documentUUID=15ce1cbc-65dc-4539-b16a-c1552b491c8f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C(=O)C1=CC=C(C=C1)OCC2=CC=CC=C2)Br,https://pubchem.ncbi.nlm.nih.gov/compound/100040,PubChem,CC(Br)C(=O)c1ccc(OCc2ccccc2)cc1,Train "EU_REACH: 4-(methoxycarbonyl)-3-nitrobenzoic acid",,35092-89-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5758/7/4/2/?documentUUID=e5f1c75a-329a-4e6a-bc04-e9675729425d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1=C(C=C(C=C1)C(=O)O)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/98592,PubChem,COC(=O)c1ccc(C(=O)O)cc1[N+](=O)[O-],Train "EU_REACH: 2-[2-(dimethylamino)ethoxy]ethyl N-{[1,3,3-trimethyl-5-(9-methyl-2-oxo-3,6-dioxa-1,9-diazadecan-1-yl)cyclohexyl]methyl}carbamate",,351197-46-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12553/7/4/2/?documentUUID=69ac8112-39d1-471c-bd93-a260ffd4d8cf,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(CC(CC(C1)(C)CNC(=O)OCCOCCN(C)C)NC(=O)OCCOCCN(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/53424022,PubChem,CN(C)CCOCCOC(=O)NCC1(C)CC(NC(=O)OCCOCCN(C)C)CC(C)(C)C1,Train "EU_REACH: 2-hydroxy-N,N-dimethylpropanamide",,35123-06-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11068/7/4/2/?documentUUID=d8ca089a-e466-45d2-b8d3-a06af6f36f0a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C(=O)N(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/98053,PubChem,CC(O)C(=O)N(C)C,Train "EU_REACH: (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl methanesulfonate",,35130-97-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1387/7/4/2/?documentUUID=1d632d16-7df3-4d96-baf2-a409cae30185,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN1[C@@H]2CC[C@H]1CC(C2)OS(=O)(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/16125705,PubChem,CN1[C@@H]2CC[C@H]1CC(OS(C)(=O)=O)C2,Train "EU_REACH: 4,4'-[(3,3'-dichlorobiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis(5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one)",,3520-72-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15775/7/4/2/?documentUUID=4540df1b-e1da-430d-9523-8d1abfbed98c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC\1=NN(C(=O)C1=N/Nc2ccc(cc2Cl)c3ccc(N\N=C4/C(=NN(C4=O)c5ccccc5)C)c(Cl)c3)c6ccccc6,https://cactus.nci.nih.gov/chemical/structure/3520-72-7/smiles,CACTUS,CC1=NN(c2ccccc2)C(=O)/C1=N/Nc1ccc(-c2ccc(N/N=C3/C(=O)N(c4ccccc4)N=C3C)c(Cl)c2)cc1Cl,Train "NZ_CCID: 4-Fluorobenzyl chloride",,352-11-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FF911EC7-380A-42FE-ABD8-7CB9419BBFCF,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1CCl)F,https://pubchem.ncbi.nlm.nih.gov/compound/9602,PubChem,Fc1ccc(CCl)cc1,Train "EU_REACH: 10-[4-(2-chloroethyl)piperazin-1-yl]-2-thia-9-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaene",,352232-17-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24114/7/4/2/?documentUUID=56e004c0-afcd-40e0-a8dd-2865790fc52e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CN(CCN1)C2=NC3=CC=CC=C3SC4=C(C=CC=C42)CCCl,https://pubchem.ncbi.nlm.nih.gov/compound/57349184,PubChem,ClCCc1cccc2c1Sc1ccccc1N=C2N1CCNCC1,Train "EU_REACH: (2-fluoro-3-methoxyphenyl)boronic acid",,352303-67-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30900/7/4/2/?documentUUID=8a810fc9-0288-461e-8cd4-a8b8cd0506ba,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,B(C1=C(C(=CC=C1)OC)F)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/4985744,PubChem,COc1cccc(B(O)O)c1F,Train "EU_REACH: 2,2,2-trifluoroethyl methacrylate",,352-87-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18658/7/4/2/?documentUUID=20524d67-af6d-453a-a6bc-35f3dd754473,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OCC(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/9608,PubChem,C=C(C)C(=O)OCC(F)(F)F,Train "EU_REACH: triethoxy(2,4,4-trimethylpentyl)silane",,35435-21-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16000/7/4/2/?documentUUID=9b71a814-62b8-4353-9cb5-1b0c393adc74,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](CC(C)CC(C)(C)C)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/169694,PubChem,CCO[Si](CC(C)CC(C)(C)C)(OCC)OCC,Train "EU_REACH: 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid",,35453-19-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5239/7/4/2/?documentUUID=77bc7fbf-f772-48a7-bb7b-82e348742fde,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1(=C(C(=C(C(=C1I)N)I)C(=O)O)I)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/3015783,PubChem,Nc1c(I)c(C(=O)O)c(I)c(C(=O)O)c1I,Train "EU_REACH: perfluoro(methylcyclohexane)",,355-02-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24227/7/4/2/?documentUUID=0bbe6efe-0f0d-44b7-aae4-303aadbb7658,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1(C(C(C(C(C1(F)F)(F)F)(F)F)(F)F)(F)F)(C(F)(F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/9637,PubChem,FC(F)(F)C1(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C1(F)F,Train "JP_CHRIP: imazalil (ISO); 1-[2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole","JP_CHRIP: 1-(2-(2,4-Dichlorophenyl)-2-(2-propenyloxy)ethyl)-1H-imidazole 1-[2-(Allyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole (synonym:imazalil) Allyl 1-(2,4-dichlorophenyl)-2-imidazol-1-ylethyl ether Enilconazole",35554-44-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0268e.html,"JP_CHRIP: In Draize tests using rabbits, mild skin irritation was detected (JMPR No. 12, 2005). However, in different tests using rabbits (OECD TG 404), erythema or oedema was not observed, and the substance was found to not be an irritant (JMPR No. 8 (2000)). In addition, in skin irritation tests involving several volunteers, no symptoms such as burning, itching or pain were detected (JMPR No. 8 (2000)). Based on these documents, the substance was classified into ""Not classified"".",Provided,JP_CHRIP,1,Clc1ccc(C(Cn2ccnc2)OCC=C)c(Cl)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J21.235K,J-GLOBAL,C=CCOC(Cn1ccnc1)c1ccc(Cl)cc1Cl,Train "EU_REACH: trifluoromethanesulphonic anhydride KR_NCIS: Trifluoromethanesulfonic anhydride NZ_CCID: Trifluoromethanesulphonic anhydride","NZ_CCID: trifluoromethanesulfonic anhydride",358-23-6,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22478/7/4/2/?documentUUID=1774eb89-93b1-43c9-b3ca-cd9e1253c6cf KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F56F8554-69A5-484E-9820-35FCF0962A3B","EU_REACH: Experimental study (OECD TG 404, GLP) NZ_CCID: Skin Irritation R PHRASE: R 35 [Company Data] Eye Irritation R PHRASE: R 35 [Company Data]",Provided,"EU_REACH, KR_NCIS, NZ_CCID",3,C(F)(F)(F)S(=O)(=O)OS(=O)(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/67749,PubChem,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F,Train "EU_REACH: 6H-dibenz[c,e][1,2]oxaphosphorin 6-oxide",,35948-25-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5483/7/4/2/?documentUUID=7c6c3a1d-6fc1-4239-9407-24560709b328,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)C3=CC=CC=C3[P+](=O)O2,https://pubchem.ncbi.nlm.nih.gov/compound/6328250,PubChem,O=[p+]1oc2ccccc2c2ccccc21,Train "EU_REACH: 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione",,36062-04-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7283/7/4/2/?documentUUID=457fb42d-ef90-43cc-b95b-19142f1ca459,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=C(C=CC(=C1)CCC(=O)CC(=O)CCC2=CC(=C(C=C2)O)OC)O,https://pubchem.ncbi.nlm.nih.gov/compound/124072,PubChem,COc1cc(CCC(=O)CC(=O)CCc2ccc(O)c(OC)c2)ccc1O,Train "EU_REACH: ethyl 1-[2-(2,4-dichlorophenyl)acetoxy]cyclohexanecarboxylate",,361366-16-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7292/7/4/2/?documentUUID=a9b896eb-eca5-4aa1-9114-555b62324b70,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1(CCCCC1)OC(=O)CC2=C(C=C(C=C2)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/22894816,PubChem,CCOC(=O)C1(OC(=O)Cc2ccc(Cl)cc2Cl)CCCCC1,Train "EU_REACH: (2S)-2-{[(tert-butoxy)carbonyl]amino}-2-(3-hydroxyadamantan-1-yl)acetic acid",,361442-00-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13388/7/4/2/?documentUUID=fd45cd9c-00e4-4f29-ab7f-a90d99e1365b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)OC(=O)N[C@H](C(=O)O)C12CC3CC(C1)CC(C3)(C2)O,https://pubchem.ncbi.nlm.nih.gov/compound/11723843,PubChem,CC(C)(C)OC(=O)N[C@H](C(=O)O)C12CC3CC(CC(O)(C3)C1)C2,Train "EU_REACH: 2-{[2-(acetyloxy)ethyl]({4-[ (E)-2-(2-bromo-4,6-dinitrophenyl)diazen-1-yl]-5acetamido-2-methoxyphenyl})amino}ethyl acetate",,3618-72-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17330/7/4/2/?documentUUID=d9905401-7742-4d05-a9b2-f328c3d3a4ef,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)NC1=CC(=C(C=C1N=NC2=C(C=C(C=C2Br)[N+](=O)[O-])[N+](=O)[O-])OC)N(CCOC(=O)C)CCOC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/77172,PubChem,COc1cc(N=Nc2c(Br)cc([N+](=O)[O-])cc2[N+](=O)[O-])c(NC(C)=O)cc1N(CCOC(C)=O)CCOC(C)=O,Train "EU_REACH: ({5-acetamido-4-[(2-chloro-4,6-dinitrophenyl)diazenyl]-2-methoxyphenyl}imino)diethane-2,1-diyl diacetate",,3618-73-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18576/7/4/2/?documentUUID=87dfa8c7-47dd-4ec3-876f-1c47ebcb757b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)NC1=CC(=C(C=C1N=NC2=C(C=C(C=C2Cl)[N+](=O)[O-])[N+](=O)[O-])OC)N(CCOC(=O)C)CCOC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/77173,PubChem,COc1cc(N=Nc2c(Cl)cc([N+](=O)[O-])cc2[N+](=O)[O-])c(NC(C)=O)cc1N(CCOC(C)=O)CCOC(C)=O,Train "EU_REACH: N-butylbenzenesulfonamide",,3622-84-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13402/7/4/2/?documentUUID=103c0bc0-a4f3-4ee8-b901-cf33a3229dc3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCNS(=O)(=O)C1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/19241,PubChem,CCCCNS(=O)(=O)c1ccccc1,Train "EU_REACH: 1,4-Dihydroxy-2,2,6,6-tetramethylpiperidine",,3637-10-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16531/7/4/2/?documentUUID=dc4c0dab-62e6-4ee2-bced-7df2521e2a56,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(CC(CC(N1O)(C)C)O)C,https://pubchem.ncbi.nlm.nih.gov/compound/5395,PubChem,CC1(C)CC(O)CC(C)(C)N1O,Train "EU_REACH: 3-(-lambda5-diazynylidene)-4-oxo-3,4-dihydronaphthalene-1-sulfonyl chloride",,36451-09-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27336/7/4/2/?documentUUID=2f8dc1bf-4f81-4f1c-a7bf-b9927039c8f9,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,Cl[S](=O)(=O)C1=CC(=[N+]=[N-])C(=O)c2ccccc12,https://cactus.nci.nih.gov/chemical/structure/36451-09-9/smiles,CACTUS,[N-]=[N+]=C1C=C(S(=O)(=O)Cl)c2ccccc2C1=O,Train "JP_CHRIP: 3-Bromo-2,2-bis(bromomethyl)propan-1-ol","JP_CHRIP: Tribromoneopentyl alcohol",36483-57-5,NC,JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-mhlw-0003.html,"JP_CHRIP: 【分類根拠】 （１）より、区分に該当しない。 【根拠データ】 （１）ウサギ（n = 3）を用いた皮膚刺激性試験（OECD TG 404、半閉塞、4時間適用、72時間観察）において、皮膚刺激性はみられなかった（紅斑・痂皮スコア：0/0/0、浮腫スコア：0/0/0）との報告がある（REACH登録情報 (Accessed Sep. 2021)）。",Provided,JP_CHRIP,1,OCC(CBr)(CBr)CBr,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J111.581B,J-GLOBAL,OCC(CBr)(CBr)CBr,Train "EU_REACH: 7,7,8,9,9-pentamethyl-2H,4H,4aH,5H,6H,7H,8H,9H,9bH-indeno[4,5-d][1,3]dioxine",,365411-50-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11467/7/4/2/?documentUUID=6c3d18c1-04fa-4a48-b153-dac6962bea8f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1C(C2=C(C1(C)C)C3C(CC2)COCO3)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/15552386,PubChem,CC1C(C)(C)C2=C(C3OCOCC3CC2)C1(C)C,Train "EU_REACH: 3-chloro-4-fluoroaniline",,367-21-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24633/7/4/2/?documentUUID=08781fe6-c742-46fe-8725-65482f5918c4,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C=C1N)Cl)F,https://pubchem.ncbi.nlm.nih.gov/compound/9708,PubChem,Nc1ccc(F)c(Cl)c1,Train "NZ_CCID: Propanoic acid, 2,3-dichloro-, methyl ester",,3674-09-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9074786B-5072-4C50-A939-2D0D7BC2E5F9,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41[CHEMWATCH]",,NZ_CCID,1,COC(=O)C(CCl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/95429,PubChem,COC(=O)C(Cl)CCl,Train "NZ_CCID: 4-Amino-2,2,6,6-tetramethylpiperidine",,36768-62-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C04A6780-6DBF-4A33-B19E-C212015AA8C9,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC1(CC(CC(N1)(C)C)N)C,https://pubchem.ncbi.nlm.nih.gov/compound/37524,PubChem,CC1(C)CC(N)CC(C)(C)N1,Train "EU_REACH: 7-[2-(2-hydroxymethylethoxy)methylethoxy]tetramethyl-3,6,8,11-tetraoxa-7-phosphatridecane-1,13-diol",,36788-39-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5793/7/4/2/?documentUUID=3354e0cd-ac3c-4bc5-85b6-c68fc393ff80,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(COCCCO)OP(OCCOCCO)OCCOC(C)(C)C(C)(C)O,https://pubchem.ncbi.nlm.nih.gov/compound/169815,PubChem,CC(COCCCO)OP(OCCOCCO)OCCOC(C)(C)C(C)(C)O,Train "EU_REACH: (Z)-hex-3-enyl acetate",,3681-71-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12829/7/4/2/?documentUUID=29322a10-8fb1-485f-b6ab-a7ad07a2973c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC/C=C\CCOC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/5363388,PubChem,CC/C=C\CCOC(C)=O,Train "EU_REACH: 5,5'-(1H-isoindole-1,3(2H)-diylidene)dipyrimidine-2,4,6(1H,3H,5H)-trione",,36888-99-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13313/7/4/2/?documentUUID=30b1e191-a3d8-4b50-9af4-78f9d2e80f26,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)C(=C3C(=O)NC(=O)NC3=O)N=C2C4=C(NC(=O)NC4=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/160357,PubChem,O=C1NC(=O)C(=C2N=C(c3c(O)[nH]c(=O)[nH]c3=O)c3ccccc32)C(=O)N1,Train "EU_REACH: 2,2',2''-Nitrilotriethanol, propoxylated",,37208-53-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14569/7/4/2/?documentUUID=8c8735d2-7058-44ed-aeec-1f1449d0ed45,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CO)OCC(C)OCC(C)OCCN(CCOCC(C)OCC(C)OCC(C)O)CCOCC(C)OCC(C)OCC(C)O,https://pubchem.ncbi.nlm.nih.gov/compound/73555758,PubChem,CC(O)COC(C)COC(C)COCCN(CCOCC(C)OCC(C)OCC(C)O)CCOC(C)COC(C)COC(C)CO,Train "NZ_CCID: Cyanoacetic acid",,372-09-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1226DFFA-F378-4188-8410-540F188842D9,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(C#N)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/9740,PubChem,N#CCC(=O)O,Train "NZ_CCID: Cyclobutanecarboxylic acid",,3721-95-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C010E7EF-272F-4AE9-A9F6-FA7B0561D4DE,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CC(C1)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/19494,PubChem,O=C(O)C1CCC1,Train "NZ_CCID: 2-(Aminomethyl) pyridine",,3731-51-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/854629E5-CDCC-43A2-835C-3C7B9FA54697,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=NC(=C1)CN,https://pubchem.ncbi.nlm.nih.gov/compound/19509,PubChem,NCc1ccccn1,Train "NZ_CCID: 3-(Aminomethyl) pyridine",,3731-52-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7606FA3E-BC61-4BE1-B81D-AFB7B6E55B10,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CN=C1)CN,https://pubchem.ncbi.nlm.nih.gov/compound/31018,PubChem,NCc1cccnc1,Train "EU_REACH: (3aR,5aS,9aS,9bR)-3a,6,6,9a-tetramethyl-dodecahydronaphtho[2,1-b]furan; (3aR,5aS,9aS,9bS)-3a,6,6,9a-tetramethyl-dodecahydronaphtho[2,1-b]furan; (3aS,5aR,9aR,9bR)-3a,6,6,9a-tetramethyl-dodecahydronaphtho[2,1-b]furan; (3aS,5aR,9aR,9bS)-3a,6,6,9a-tetramethyl-dodecahydronaphtho[2,1-b]furan",,3738-00-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16416/7/4/2/?documentUUID=33f28e6d-64b5-416f-8c32-784c24f0068e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(CCCC2(C1CCC3(C2CCO3)C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/107166,PubChem,CC1(C)CCCC2(C)C1CCC1(C)OCCC12,Train "EU_REACH: 5-amino-2,4,6-triiodobenzene-1,3-dicarbonyl dichloride",,37441-29-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12669/7/4/2/?documentUUID=e9e655b2-bb0b-4d42-803e-567ca7c9d80c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1(=C(C(=C(C(=C1I)N)I)C(=O)Cl)I)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/9894858,PubChem,Nc1c(I)c(C(=O)Cl)c(I)c(C(=O)Cl)c1I,Train "NZ_CCID: Heptafluorobutyryl chloride",,375-16-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D9791ECB-F0B3-403A-BC26-911ABF08236C,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(=O)(C(C(C(F)(F)F)(F)F)(F)F)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/67810,PubChem,O=C(Cl)C(F)(F)C(F)(F)C(F)(F)F,Train "NZ_CCID: Perfluorobutyric acid","NZ_CCID: Butanoic acid, heptafluoro-",375-22-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/80DB4B3B-54C4-4A8E-AA90-E45D838D3CFC,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C(=O)(C(C(C(F)(F)F)(F)F)(F)F)O,https://pubchem.ncbi.nlm.nih.gov/compound/9777,PubChem,O=C(O)C(F)(F)C(F)(F)C(F)(F)F,Train "EU_REACH: 4,4'-bis(methoxymethyl)-1,1'-biphenyl",,3753-18-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1633/7/4/2/?documentUUID=15be8d1e-2fb8-434c-9f41-14a96d5631fd,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COCC1=CC=C(C=C1)C2=CC=C(C=C2)COC,https://pubchem.ncbi.nlm.nih.gov/compound/1519430,PubChem,COCc1ccc(-c2ccc(COC)cc2)cc1,Train "US_HSDB: Perfluorobutanesulfonic acid",,375-73-5,Cat 1,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8294,,,US_HSDB,1,C(C(C(F)(F)S(=O)(=O)O)(F)F)(C(F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/67815,PubChem,O=S(=O)(O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train "US_HSDB: Perfluoroheptanoic acid",,375-85-9,Cat 1,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8293,,,US_HSDB,1,C(=O)(C(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)O,https://pubchem.ncbi.nlm.nih.gov/compound/67818,PubChem,O=C(O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train "EU_REACH: 5-cyclohexadecen-1-one",,37609-25-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19655/7/4/2/?documentUUID=96719c40-821a-4f0a-9d8c-2c9abe420638,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CCCCCC(=O)CCCC=CCCCC1,https://pubchem.ncbi.nlm.nih.gov/compound/162268,PubChem,O=C1CCCC=CCCCCCCCCCC1,Train "EU_REACH: {bis[(butan-2-yl)amino](methyl)silyl}(butan-2-yl)amine",,37697-65-7,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23673/7/4/2/?documentUUID=c41b50ae-33e3-451d-bb29-d6e76d257b32,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C)N[Si](C)(NC(C)CC)NC(C)CC,https://pubchem.ncbi.nlm.nih.gov/compound/169958,PubChem,CCC(C)N[Si](C)(NC(C)CC)NC(C)CC,Train "EU_REACH: 6-(-lambda5-diazynylidene)-5-oxo-5,6-dihydronaphthalene-2-sulfonyl chloride",,3770-97-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27752/7/4/2/?documentUUID=47012ac2-fb09-4da4-b258-97a21f657d6a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC2=C(C=CC(=C2[O-])[N+]#N)C(=C1)S(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/107462,PubChem,N#[N+]c1ccc2c(S(=O)(=O)Cl)cccc2c1[O-],Train "EU_REACH: methyl (2R)-2-amino-2-(4-hydroxyphenyl)acetate",,37763-23-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10444/7/4/2/?documentUUID=d829d5af-76dd-4278-b509-5e68cb66433a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)[C@@H](C1=CC=C(C=C1)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/11298312,PubChem,COC(=O)[C@H](N)c1ccc(O)cc1,Train "EU_REACH: (4E,9E)-4,7,10-trimethyl-7-{[(E)-(pentan-2-ylidene)amino]oxy}-6,8-dioxa-5,9-diaza-7-silatrideca-4,9-diene",,37859-55-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10483/7/4/2/?documentUUID=f9709787-7856-428f-b71b-68a0be09b8df,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC/C(=N/O[Si](O/N=C(/CCC)\C)(O/N=C(/CCC)\C)C)/C,https://pubchem.ncbi.nlm.nih.gov/compound/154734426,PubChem,CCC/C(C)=N/O[Si](C)(O/N=C(\C)CCC)O/N=C(\C)CCC,Train "EU_REACH: [(4-{6-tert-butyl-7-chloro-1H-pyrazolo[1,5-b][1,2,4]triazol-2-yl}phenyl)carbamoyl]methyl 2-hexyldecanoate",,379268-96-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/3405/7/4/2/?documentUUID=48d32d91-a4ca-4d37-ae69-dd526db201c0,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCC(CCCCCC)C(=O)OCC(=O)NC1=CC=C(C=C1)C2=NN3C(=N2)C(=C(N3)C(C)(C)C)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/58800829,PubChem,CCCCCCCCC(CCCCCC)C(=O)OCC(=O)Nc1ccc(-c2nc3c(Cl)c(C(C)(C)C)[nH]n3n2)cc1,Train "EU_REACH: Glycine, N-acetyl-N-[3-(trifluoromethyl)phenyl]valyl-, ethyl ester",,379685-94-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25397/7/4/2/?documentUUID=ddb9923b-293b-4f46-9f0d-d433d5c9f8b1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)CNC(=O)C(C(C)C)N(C1=CC=CC(=C1)C(F)(F)F)C(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/10178334,PubChem,CCOC(=O)CNC(=O)C(C(C)C)N(C(C)=O)c1cccc(C(F)(F)F)c1,Train "EU_REACH: 2,2-bis(chloromethyl)propane-1,3-diyl tetrakis(2-chloroethyl) bis(phosphate)",,38051-10-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13748/7/4/2/?documentUUID=648831a0-0465-4977-bfbb-069db6af8927,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CCl)OP(=O)(OCCCl)OCC(COP(=O)(OCCCl)OCCCl)(CCl)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/92310,PubChem,O=P(OCCCl)(OCCCl)OCC(CCl)(CCl)COP(=O)(OCCCl)OCCCl,Train "NZ_CCID: Diethylaminosulphur trifluoride",,38078-09-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DFF17B20-BB23-455A-B10A-5FEE26BCF8CE,"NZ_CCID: Skin Irritation R PHRASE: R 35 [Company Data] Eye Irritation R PHRASE: R 35 [Company Data]",,NZ_CCID,1,CCN(CC)S(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/123472,PubChem,CCN(CC)S(F)(F)F,Train "JP_CHRIP: Difluoroacetic acid",,381-73-7,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-0022e.html,"JP_CHRIP: [Rationale for the Classification] Based on (1), since this substance was a strong acid (pH <= 2), it was classified in Category 1 in accordance with the GHS Classification Guidance for the Japanese Government. [Evidence Data] (1) The measured pH value of this substance (1% solution) was 1.28 (24 deg C), which corresponded to a strong acid (pH <= 2) (REACH registration dossier (Access on November 2019)).",,JP_CHRIP,1,OC(=O)C(F)F,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J54.208C,J-GLOBAL,O=C(O)C(F)F,Train "EU_REACH: 2-[difluoro(methoxy)methyl]-1,1,1,3,3,3-hexafluoropropane",,382-26-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7493/7/4/2/?documentUUID=beff31ec-7dd2-4b30-9b91-273c7d6a2786,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(C(C(F)(F)F)C(F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/45459,PubChem,COC(F)(F)C(C(F)(F)F)C(F)(F)F,Train "EU_REACH: 2,2,3,3,5,5,6,6-octafluoro-4-(trifluoromethyl)morpholine",,382-28-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10245/7/4/2/?documentUUID=9ba97411-2f32-4e82-81f6-f2d088f97f5c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1(C(OC(C(N1C(F)(F)F)(F)F)(F)F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/67839,PubChem,FC(F)(F)N1C(F)(F)C(F)(F)OC(F)(F)C1(F)F,Train "AU_HCIS: Silane, dichloromethyl(3,3,4,4,5,5,6,6,6-nonafluorohexyl)-",,38436-16-7,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6554,,,AU_HCIS,1,C[Si](CCC(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/2776177,PubChem,C[Si](Cl)(Cl)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train "EU_REACH: 1,3-bis(isocyanatomethyl)cyclohexane",,38661-72-2,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27064/7/4/2/?documentUUID=b1295745-8ea6-4725-934d-a56d8c18ecdc,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC(CC(C1)CN=C=O)CN=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/53172,PubChem,O=C=NCC1CCCC(CN=C=O)C1,Train "NZ_CCID: Octadecanamide, N,N-dimethyl-",,3886-90-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/307264BC-968E-46BC-8B34-52A3AA0E91F0,,,NZ_CCID,1,CCCCCCCCCCCCCCCCCC(=O)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/19765,PubChem,CCCCCCCCCCCCCCCCCC(=O)N(C)C,Train "EU_REACH: (1-ethoxyethoxy)cyclododecane",,389083-83-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27298/7/4/2/?documentUUID=b2d182c8-f4db-48bd-9802-7b287ba402c7,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(C)OC1CCCCCCCCCCC1,https://pubchem.ncbi.nlm.nih.gov/compound/22717736,PubChem,CCOC(C)OC1CCCCCCCCCCC1,Train "EU_REACH: 3,5-dimethoxy-4-propoxybenzaldehyde",,39075-26-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30813/7/4/2/?documentUUID=1d1e731a-fa0c-4f1f-9bcd-112dbf2c6210,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCOC1=C(C=C(C=C1OC)C=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/4771124,PubChem,CCCOc1c(OC)cc(C=O)cc1OC,Train "EU_REACH: 2-butyloctan-1-ol",,3913-02-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11955/7/4/2/?documentUUID=2d336c1f-d89c-43b2-b449-e5793536114d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCC(CCCC)CO,https://pubchem.ncbi.nlm.nih.gov/compound/19800,PubChem,CCCCCCC(CO)CCCC,Train "NZ_CCID: (1R)-(-)-Camphor-10-sulphonic acid chloride",,39262-22-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/22B35975-C77B-4682-8035-58571384EA79,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC1([C@H]2CC[C@@]1(C(=O)C2)CS(=O)(=O)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/9816396,PubChem,CC1(C)[C@H]2CC[C@]1(CS(=O)(=O)Cl)C(=O)C2,Train "NZ_CCID: 2-Fluorobenzoyl chloride",,393-52-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/92A2E229-5C95-405C-91A5-17D2D3F29D79,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)C(=O)Cl)F,https://pubchem.ncbi.nlm.nih.gov/compound/9808,PubChem,O=C(Cl)c1ccccc1F,Train "EU_REACH: 5-Fluoro-2-nitrobenzoic acid methyl ester",,393-85-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10865/7/4/2/?documentUUID=d10141ce-b662-4e1e-8f7a-9cb13c89214e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1=C(C=CC(=C1)F)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/5152049,PubChem,COC(=O)c1cc(F)ccc1[N+](=O)[O-],Train "NZ_CCID: 1-Octanesulphonic acid",,3944-72-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C0AFB335-8E2D-4ED2-A082-7615B18BB3FE,,,NZ_CCID,1,CCCCCCCCS(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/49939,PubChem,CCCCCCCCS(=O)(=O)O,Train "NZ_CCID: (IS)-(-) Camphonic acid chloride",,39637-74-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1B2D5C75-B1B2-48D0-83FB-A116BFD64D88,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C[C@@]12CC[C@@](C1(C)C)(OC2=O)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/170232,PubChem,CC1(C)[C@@]2(C)CC[C@]1(C(=O)Cl)OC2=O,Train "KR_NCIS: Ethylene phosphorodifluoridite",,3965-00-2,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C(COP(F)F)OP(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/23234030,PubChem,FP(F)OCCOP(F)F,Train "AU_HCIS: Hexadecanamide, N-[3-(dimethylamino)propyl]-",,39669-97-1,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6764,,,AU_HCIS,1,CCCCCCCCCCCCCCCC(=O)NCCCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/38313,PubChem,CCCCCCCCCCCCCCCC(=O)NCCCN(C)C,Train "EU_REACH: 2-[2-(2-ethoxyethoxy)ethoxy]ethyl methacrylate",,39670-09-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15995/7/4/2/?documentUUID=84f3f95c-4c67-49c3-bb9f-730fc70a29d4,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOCCOCCOCCOC(=O)C(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/162388,PubChem,C=C(C)C(=O)OCCOCCOCCOCC,Train "JP_CHRIP: Ammonium methylcarbamodithioate; Metam-ammonium","JP_CHRIP: ammonium N-methyldithiocarbamate Carbamodithioic acid, N-methyl-, ammonium salt (1:1) Methyldithiocarbamic acid, ammonium salt",39680-90-5,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-0027e.html,"JP_CHRIP: [Rationale for the Classification] It was classified in Category 1 from (1). [Evidence Data] (1) In a skin irritation test with rabbits, tissue destruction was observed, and it was judged as corrosive (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)).",,JP_CHRIP,1,CNC(=S)S[N+],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.040E,J-GLOBAL,CNC(=S)S[N+],Train "EU_REACH: 1,3,3,5-tetramethyl-1,1,5,5-tetraphenyltrisiloxane",,3982-82-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21455/7/4/2/?documentUUID=2057d42d-4d8f-4a0b-a821-326862b16a30,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](C)(O[Si](C)(C1=CC=CC=C1)C2=CC=CC=C2)O[Si](C)(C3=CC=CC=C3)C4=CC=CC=C4,https://pubchem.ncbi.nlm.nih.gov/compound/19882,PubChem,C[Si](C)(O[Si](C)(c1ccccc1)c1ccccc1)O[Si](C)(c1ccccc1)c1ccccc1,Train "EU_REACH: 2-amino-5-bromopyridin-3-ol",,39903-01-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10834/7/4/2/?documentUUID=c81c03ec-9928-4f91-9104-5d7bf9287668,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(C=NC(=C1O)N)Br,https://pubchem.ncbi.nlm.nih.gov/compound/11694041,PubChem,Nc1ncc(Br)cc1O,Train "EU_REACH: Urea,N'-[3-[[[(dimethylamino)carbonyl]amino]methyl]-3,5,5-trimethylcyclohexyl]-N,N-dimethyl-",,39992-90-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21212/7/4/2/?documentUUID=8a510312-5192-476b-b735-d7a1ff7d8ae6,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(CC(CC(C1)(C)CNC(=O)N(C)C)NC(=O)N(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/21155941,PubChem,CN(C)C(=O)NCC1(C)CC(NC(=O)N(C)C)CC(C)(C)C1,Train "EU_REACH: 3-(2-chlorophenyl)-3-oxopropanenitrile",,40018-25-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15696/7/4/2/?documentUUID=cb352bfe-b57e-45bb-94c7-0108401cf9cf,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C(=C1)C(=O)CC#N)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/2734201,PubChem,N#CCC(=O)c1ccccc1Cl,Train "EU_REACH: 1,4-dithiane-2,5-diol",,40018-26-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19050/7/4/2/?documentUUID=53d479d9-90c8-4ab8-ad94-778043422a06,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C(SCC(S1)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/98330,PubChem,OC1CSC(O)CS1,Train "EU_REACH: (3S)-1,3,4-trihydroxybutan-2-one",,40031-31-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30699/7/4/2/?documentUUID=4eddc958-cb03-4623-8c1f-a19cc7ad4662,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(C(C(=O)CO)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/162406,PubChem,O=C(CO)C(O)CO,Train "JP_CHRIP: 2-Methoxyethyl 2-[4-(tert-butyl)phenyl]-2-cyano-3-oxo-3-[2-(trifluoromethyl)phenyl]propanoate; Cyflumetofen",,400882-07-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0050e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1), (2). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 72-hour observation), no skin irritation reactions were observed in any animal (erythema/eschar score: 0/0/0, edema score: 0/0/0) (ECHA RAC Opinion (2017), CLH Report (2016)). (2) It is reported that in a skin irritation test with rabbits (n = 3) (GLP, semi-occlusive, 4-hour application, 72-hour observation), no skin irritation reactions were seen in any animal (erythema/eschar score: 0/0/0, edema score: 0/0/0) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2017)).",Provided,JP_CHRIP,1,COCCOC(=O)C(C#N)(C(=O)c1ccccc1C(F)(F)F)c1ccc(cc1)C(C)(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.193.546H,J-GLOBAL,COCCOC(=O)C(C#N)(C(=O)c1ccccc1C(F)(F)F)c1ccc(C(C)(C)C)cc1,Train "NZ_CCID: Cyclopropanecarboxylic acid chloride",,4023-34-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C96FB264-DFA8-47DF-AF07-F28A8EF37C7D,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CC1C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/77637,PubChem,O=C(Cl)C1CC1,Train "NZ_CCID: 4-Fluorobenzoyl chloride",,403-43-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/49543CF3-41D7-4AF0-A984-01B536578800,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1C(=O)Cl)F,https://pubchem.ncbi.nlm.nih.gov/compound/67879,PubChem,O=C(Cl)c1ccc(F)cc1,Train "EU_REACH: 2-[(1-amino-4-hydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)oxy]ethyl ethyl carbonate",,40530-60-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10046/7/4/2/?documentUUID=38991f8c-b90f-4718-a130-d2074deafaaa,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)OCCOC1=C(C2=C(C(=C1)O)C(=O)C3=CC=CC=C3C2=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/162415,PubChem,CCOC(=O)OCCOc1cc(O)c2c(c1N)C(=O)c1ccccc1C2=O,Train "EU_REACH: 1,1,2,2,3,3-hexafluoro-1-[(1,2,2-trifluoroethenyl)oxy]-3-(trifluoromethoxy)propane",,40573-09-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27489/7/4/2/?documentUUID=d761f6ea-bee3-464f-bc06-4d85acd847d9,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(=C(F)F)(OC(C(C(OC(F)(F)F)(F)F)(F)F)(F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/22613616,PubChem,FC(F)=C(F)OC(F)(F)C(F)(F)C(F)(F)OC(F)(F)F,Train "EU_REACH: tris[(4-tert-butyl-3-hydroxy-2,6-dimethylphenyl)methyl]-1,3,5-triazinane-2,4,6-trione",,40601-76-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13735/7/4/2/?documentUUID=d7ddc148-91ca-407b-8078-9a5f59de4f1b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C(=C1CN2C(=O)N(C(=O)N(C2=O)CC3=C(C(=C(C=C3C)C(C)(C)C)O)C)CC4=C(C(=C(C=C4C)C(C)(C)C)O)C)C)O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/93221,PubChem,Cc1cc(C(C)(C)C)c(O)c(C)c1Cn1c(=O)n(Cc2c(C)cc(C(C)(C)C)c(O)c2C)c(=O)n(Cc2c(C)cc(C(C)(C)C)c(O)c2C)c1=O,Train "EU_REACH: N,N'-(2,5-dichloro-1,4-phenylene)bis{4-[(2,5-dichlorophenyl)diazenyl]-3-hydroxy-2-naphthamide}",,40618-31-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5670/7/4/2/?documentUUID=e82fd8bc-16fb-41e2-b860-5563b21cb592,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)C=C(C(=C2N=NC3=C(C=CC(=C3)Cl)Cl)O)C(=O)NC4=CC(=C(C=C4Cl)NC(=O)C5=CC6=CC=CC=C6C(=C5O)N=NC7=C(C=CC(=C7)Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/162420,PubChem,O=C(Nc1cc(Cl)c(NC(=O)c2cc3ccccc3c(N=Nc3cc(Cl)ccc3Cl)c2O)cc1Cl)c1cc2ccccc2c(N=Nc2cc(Cl)ccc2Cl)c1O,Train "KR_NCIS: 3,6,9,12-Tetraazatetradecane-1,14-diamine; 3,6,9,12-Tetraazatetradecamethylenediamine",,4067-16-7,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C(CNCCNCCNCCNCCN)N,https://pubchem.ncbi.nlm.nih.gov/compound/19990,PubChem,NCCNCCNCCNCCNCCN,Train "EU_REACH: 1,1,2,2-tetrafluoro-1-(2,2,2-trifluoroethoxy)ethane",,406-78-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30633/7/4/2/?documentUUID=bbfdc696-7f65-46e1-b9e8-e632583d6351,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(C(F)(F)F)OC(C(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/164596,PubChem,FC(F)C(F)(F)OCC(F)(F)F,Train "EU_REACH: 2-[(2-cyanoethyl){4-[(4-nitrophenyl)diazenyl]phenyl}amino]ethyl benzoate",,40690-89-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18570/7/4/2/?documentUUID=81f52c23-74bb-473c-bdc7-30a4af3fe2e3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C(=O)OCCN(CCC#N)C2=CC=C(C=C2)N=NC3=CC=C(C=C3)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/162422,PubChem,N#CCCN(CCOC(=O)c1ccccc1)c1ccc(N=Nc2ccc([N+](=O)[O-])cc2)cc1,Train "NZ_CCID: Trifluoroacetic anhydride",,407-25-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2AF261F2-7517-4FDC-B1B2-ED62348315F4,"NZ_CCID: Skin Irritation R PHRASE: R 35 [Company Data] Eye Irritation R PHRASE: R 35 [Company Data]",,NZ_CCID,1,C(=O)(C(F)(F)F)OC(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/9845,PubChem,O=C(OC(=O)C(F)(F)F)C(F)(F)F,Train "NZ_CCID: 2,4-Dimethyl-3-pentylamine",,4083-57-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C738A72C-BFC5-498B-A2CD-2D5EC814D321,"NZ_CCID: Skin Irritation R-PHRASE: R 34. [Chemwatch] Eye Irritation R-PHRASE: R 34/ 41. [Chemwatch]",,NZ_CCID,1,CC(C)C(C(C)C)N,https://pubchem.ncbi.nlm.nih.gov/compound/77702,PubChem,CC(C)C(N)C(C)C,Train "EU_REACH: N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide",,40908-37-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24370/7/4/2/?documentUUID=4643aa0e-e333-487d-a641-f7c1f78d09d7,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)NC1CC(NC(C1)(C)C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/100241,PubChem,CC(=O)NC1CC(C)(C)NC(C)(C)C1,Train "EU_REACH: 3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one",,41078-70-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25825/7/4/2/?documentUUID=6c1cc7af-e86d-4e6d-884e-99f6f46bedf5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C(=O)N2C=CC=CC2=N1)CCCl,https://pubchem.ncbi.nlm.nih.gov/compound/817866,PubChem,Cc1nc2ccccn2c(=O)c1CCCl,Train "NZ_CCID: Dichloroacetic anhydride",,4124-30-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F9F67E6A-5DE3-4BD8-A319-9BC7E89B4E69,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(C(=O)OC(=O)C(Cl)Cl)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/77772,PubChem,O=C(OC(=O)C(Cl)Cl)C(Cl)Cl,Train "EU_REACH: [(3aS,4S,6S)-6-methoxy-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methyl 4-methylbenzene-1-sulfonate",,4137-56-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22244/7/4/2/?documentUUID=1606047f-bf41-4301-80e4-7e5d01fe7c7e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)S(=O)(=O)OC[C@@H]2[C@@H]3[C@H]([C@@H](O2)OC)OC(O3)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/11013769,PubChem,CO[C@@H]1O[C@H](COS(=O)(=O)c2ccc(C)cc2)[C@H]2OC(C)(C)O[C@@H]12,Train "EU_REACH: N-(4-acetamidophenyl)-3-hydroxy-2-naphthamide",,41506-62-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10876/7/4/2/?documentUUID=17c92dc7-6666-430d-89d5-d149c937a522,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)NC1=CC=C(C=C1)NC(=O)C2=CC3=CC=CC=C3C=C2O,https://pubchem.ncbi.nlm.nih.gov/compound/170529,PubChem,CC(=O)Nc1ccc(NC(=O)c2cc3ccccc3cc2O)cc1,Train "EU_REACH: O,O,O-tris-(4-isocyanatophenyl) thiophosphate",,4151-51-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11957/7/4/2/?documentUUID=36efab26-fd4f-4c16-85e8-557c6bbff8bc,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1N=C=O)OP(=S)(OC2=CC=C(C=C2)N=C=O)OC3=CC=C(C=C3)N=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/77798,PubChem,O=C=Nc1ccc(OP(=S)(Oc2ccc(N=C=O)cc2)Oc2ccc(N=C=O)cc2)cc1,Train "EU_REACH: N-[2-[(2,6-dicyano-4-nitrophenyl)azo]-5-(diethylamino)phenyl]acetamide",,41642-51-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21426/7/4/2/?documentUUID=d945a5b6-992d-4a2d-ade7-70af51e74abd,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN(CC)C1=CC(=C(C=C1)N=NC2=C(C=C(C=C2C#N)[N+](=O)[O-])C#N)NC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/162043,PubChem,CCN(CC)c1ccc(N=Nc2c(C#N)cc([N+](=O)[O-])cc2C#N)c(NC(C)=O)c1,Train "EU_REACH: 1-palmitoyl-4-(palmitoyloxy)-L-proline",,41672-81-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20945/7/4/2/?documentUUID=93dc36a1-c382-4e94-b873-1a47a9f6db21,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCC(=O)N1C[C@@H](C[C@H]1C(=O)O)OC(=O)CCCCCCCCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/170556,PubChem,CCCCCCCCCCCCCCCC(=O)O[C@@H]1C[C@@H](C(=O)O)N(C(=O)CCCCCCCCCCCCCCC)C1,Train "EU_REACH: 1-methoxy-4-prop-1-en-1-ylbenzene",,4180-23-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13872/7/4/2/?documentUUID=0ce5decd-35bf-4334-a897-25e5cfcc1c03,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C/C=C/C1=CC=C(C=C1)OC,https://pubchem.ncbi.nlm.nih.gov/compound/637563,PubChem,C/C=C/c1ccc(OC)cc1,Train "EU_REACH: 4-Hydroxy-3,5-dimethylbenzonitrile",,4198-90-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25959/7/4/2/?documentUUID=43ef3744-6738-4b1a-8566-cdb7a8272fcb,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=CC(=C1O)C)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/20176,PubChem,Cc1cc(C#N)cc(C)c1O,Train "EU_REACH: 4-tert-butylbenzonitrile",,4210-32-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10650/7/4/2/?documentUUID=dc982657-d4a8-4cf5-8e17-ae39d2af614a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1=CC=C(C=C1)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/77883,PubChem,CC(C)(C)c1ccc(C#N)cc1,Train "NZ_CCID: Trifluoromethanesulphonyl chloride","NZ_CCID: trifluoromethanesulfonyl chloride",421-83-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D05A8ED9-59B4-4970-B134-D6B9E05AAAB3,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(F)(F)(F)S(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/79000,PubChem,O=S(=O)(Cl)C(F)(F)F,Train "EU_REACH: N,N-bis(2-hydroxypropyl)benzamide",,422278-61-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/9467/7/4/2/?documentUUID=2886a6d2-d8c7-47f0-8bdd-5c9cde1d1f40,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CN(CC(C)O)C(=O)C1=CC=CC=C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/11470407,PubChem,CC(O)CN(CC(C)O)C(=O)c1ccccc1,Train "NZ_CCID: 6-Bromohexanoic acid","NZ_CCID: 6-bromocaproic acid",4224-70-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D735F427-0BD7-463E-BE3A-B191BB6CFAEA,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(CCC(=O)O)CCBr,https://pubchem.ncbi.nlm.nih.gov/compound/20210,PubChem,O=C(O)CCCCCBr,Train "NZ_CCID: 2,2,3,3,3-Pentafluoropropionic acid","NZ_CCID: pentafluoropropionic acid",422-64-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2A7E15AF-D076-410C-B8C4-CE6563BAE0E6,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(=O)(C(C(F)(F)F)(F)F)O,https://pubchem.ncbi.nlm.nih.gov/compound/62356,PubChem,O=C(O)C(F)(F)C(F)(F)F,Train "EU_REACH: 2-methylprop-1-ene, pentamer",,42278-27-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12490/7/4/2/?documentUUID=d2ab01e5-ab18-46eb-9865-a7ef85c989b7,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/8255,PubChem,C=C(C)C,Train "EU_REACH: 1-Methyl-3-nitro-guanidine",,4245-76-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/9150/7/4/2/?documentUUID=fa290fa0-bab1-4c60-98ad-a06237d7246f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN=C(N)N[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/20237,PubChem,CN=C(N)N[N+](=O)[O-],Train "EU_REACH: methylsilanetriyl triacetate JP_CHRIP: Methylsilanetriyl triacetate NZ_CCID: Silanetriol, methyl-, triacetate, >5% in a non hazardous diluent","JP_CHRIP: Methyltriacetoxysilane; Methyltriacetoxysilane; Silane, methyltriacetoxy-; Triacetoxymethylsilane",4253-34-3,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14400/7/4/2/?documentUUID=a36fbd56-64f5-44ba-b560-a28039e745cc JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0032e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/66C959A3-1D52-47B4-ABDD-08A7B3C3347F","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: In a skin irritation test in which six rabbits were given a 4-hour semi-occlusive application of 0.5 mL of this substance (OECD TG 404, GLP), severe lesions were observed 72 hours after the application, and all the animals showed no noticeable recovery on day 14. The primary dermal irritation index was 4.17, and it was judged as corrosive (SIDS (2005)). Therefore, it was classified in Category 1. Besides, in the test, 3-minute exposure also caused erythema and edema, the dermal irritation index was 2.94, and irritation was found (SIDS (2005)). NZ_CCID: Skin Irritation Classification based on the pure chemical classification and mixture rules. Eye Irritation Classification based on the pure chemical classification and mixture rules.",Provided,"EU_REACH, JP_CHRIP, NZ_CCID",3,CC(=O)O[Si](C)(OC(=O)C)OC(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J54.327F,J-GLOBAL,CC(=O)O[Si](C)(OC(C)=O)OC(C)=O,Train "NZ_CCID: Methanesulphonic acid, trifluoro-, ethyl ester",,425-75-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6D9EBE85-02BD-44AD-989E-272EDA26E2D9,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCOS(=O)(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/67924,PubChem,CCOS(=O)(=O)C(F)(F)F,Train "EU_REACH: N-(4-chloro-2,5-dimethoxyphenyl)-3-hydroxy-2-naphthamide",,4273-92-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11395/7/4/2/?documentUUID=5b51b5e9-6ee5-4b69-99e8-2bd2727b08df,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC(=C(C=C1NC(=O)C2=CC3=CC=CC=C3C=C2O)OC)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/77955,PubChem,COc1cc(NC(=O)c2cc3ccccc3cc2O)c(OC)cc1Cl,Train "EU_REACH: N1,N3-bis(2,2,6,6-tetramethylpiperidin-4-yl)benzene-1,3-dicarboxamide",,42774-15-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16260/7/4/2/?documentUUID=304c1f7c-7c83-49d2-83db-38b19b863213,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(CC(CC(N1)(C)C)NC(=O)C2=CC(=CC=C2)C(=O)NC3CC(NC(C3)(C)C)(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6451919,PubChem,CC1(C)CC(NC(=O)c2cccc(C(=O)NC3CC(C)(C)NC(C)(C)C3)c2)CC(C)(C)N1,Train "EU_REACH: 5-methyl-1,2-oxazole-4-carboxylic acid",,42831-50-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1590/7/4/2/?documentUUID=17944925-10eb-47cc-aabd-7afa0cd6935a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=NO1)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/1425240,PubChem,Cc1oncc1C(=O)O,Train "EU_REACH: (carboxymethyl)(3-dodecanamidopropyl)dimethylazanium hydroxide",,4292-10-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12545/7/4/2/?documentUUID=0f542ac3-ee5f-4779-9785-a1abda54498b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC(=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/20280,PubChem,CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC(=O)[O-],Train "KR_NCIS: 2-n-Butyl-benzo[d]isothiazol-3-one","KR_NCIS: 1,2-Benzisothiazol-3(2H)-one, 2-butyl-; 1,2-Benzisothiazolin-3-one, 2-butyl-; 2-Butyl-1,2-benzothiazol-3(2H)-one; 2-Butyl-benzo(d)isothiazol-3-one; N-Butylbenzisothiazolin-3-one",4299-07-4,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCCCN1C(=O)C2=CC=CC=C2S1,https://pubchem.ncbi.nlm.nih.gov/compound/9837171,PubChem,CCCCn1sc2ccccc2c1=O,Train "EU_REACH: 2,6-di-tert-butyl-4-nonylphenol",,4306-88-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22681/7/4/2/?documentUUID=45c12b73-3f00-4041-b503-4e00968265cd,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCC1=CC(=C(C(=C1)C(C)(C)C)O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/78004,PubChem,CCCCCCCCCc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1,Train "EU_REACH: 2,3-difluoro-1-methoxy-4-[(trans,trans)-4'-propyl[1,1'-bicyclohexyl]-4-yl]-benzene",,431947-34-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21335/7/4/2/?documentUUID=68fe7e6f-e5c0-4f64-a039-10cd065b0735,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1CCC(CC1)C2CCC(CC2)C3=C(C(=C(C=C3)OC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/17795588,PubChem,CCCC1CCC(C2CCC(c3ccc(OC)c(F)c3F)CC2)CC1,Train "EU_REACH: (2S,3S,3aR,9aS)-3-hydroxy-2-(hydroxymethyl)-7-methyl-2,3,3a,9a-tertryhydro-6H-furo[2’,3’:4,5][1,3]oxazolo [3,2-a]pyrimidin-6-one",,433733-92-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/3994/7/4/2/?documentUUID=ea7aecbf-6e3f-4f88-9444-0b054deba8a0,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CN2[C@@H]3[C@H]([C@H]([C@@H](O3)CO)O)OC2=NC1=O,https://pubchem.ncbi.nlm.nih.gov/compound/90472642,PubChem,Cc1cn2c(nc1=O)O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]12,Train "EU_REACH: [(2S,3R,5S)-3-acetoxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl acetate",,433733-94-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11709/7/4/2/?documentUUID=59fd471b-a191-427a-aecd-36debed1e6f6,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CN(C(=O)NC1=O)[C@@H]2C[C@H]([C@@H](O2)COC(=O)C)OC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/12065176,PubChem,CC(=O)OC[C@@H]1O[C@H](n2cc(C)c(=O)[nH]c2=O)C[C@H]1OC(C)=O,Train "EU_REACH: 4-Ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl) benzenesulfonic acid",,437717-43-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6990/7/4/2/?documentUUID=475c45bd-5b29-4d78-bedc-6fc6b42678f5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1=NC(=C2N1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)O)OCC)C,https://pubchem.ncbi.nlm.nih.gov/compound/135483690,PubChem,CCCc1nc(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)O)ccc3OCC)nn12,Train "EU_REACH: bisbenzimidazo[2,1-b:2',1'-i]benzo[lmn][3,8]phenanthroline-8,17-dione",,4424-06-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18833/7/4/2/?documentUUID=2bd387d8-9055-41ed-9037-04198a0a8ea3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)N=C3N2C(=O)C4=CC=C5C6=C(C=CC3=C46)C(=O)N7C5=NC8=CC=CC=C87,https://pubchem.ncbi.nlm.nih.gov/compound/78141,PubChem,O=c1c2ccc3c4c(ccc(c24)c2nc4ccccc4n12)c(=O)n1c2ccccc2nc31,Train "EU_REACH: 2,5,7,10-tetraoxaundecane",,4431-83-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10866/7/4/2/?documentUUID=005e0317-db24-48d9-bf5a-e64924875489,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COCCOCOCCOC,https://pubchem.ncbi.nlm.nih.gov/compound/78164,PubChem,COCCOCOCCOC,Train "EU_REACH: N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutanamide",,4433-79-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1944/7/4/2/?documentUUID=c97d07b1-aaf0-40ee-84bc-c92d937d3590,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)CC(=O)NC1=CC(=C(C=C1OC)Cl)OC,https://pubchem.ncbi.nlm.nih.gov/compound/78170,PubChem,COc1cc(NC(=O)CC(C)=O)c(OC)cc1Cl,Train "EU_REACH: 3-methoxybutyl acetate",,4435-53-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5167/7/4/2/?documentUUID=6739342c-cbb4-45e7-acf2-e24f71006404,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CCOC(=O)C)OC,https://pubchem.ncbi.nlm.nih.gov/compound/20498,PubChem,COC(C)CCOC(C)=O,Train "EU_REACH: 2,6-di-tert-butyl-4-methylcyclohexyl 5-{[bis(2-ethoxy-2-oxoethyl)carbamoyl]oxy}-2-(4-tert-butylphenyl)-6-cyano-1H-pyrrolo[1,2-b][1,2,4]triazole-7-carboxylate",,444065-11-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6359/7/4/2/?documentUUID=0e9d481f-e5c8-4eb0-a775-4ecbd9869c97,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)CN(CC(=O)OCC)C(=O)OC1=C(C(=C2N1NC(=N2)C3=CC=C(C=C3)C(C)(C)C)C(=O)OC4C(CC(CC4C(C)(C)C)C)C(C)(C)C)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/70903663,PubChem,CCOC(=O)CN(CC(=O)OCC)C(=O)Oc1c(C#N)c(C(=O)OC2C(C(C)(C)C)CC(C)CC2C(C)(C)C)c2nc(-c3ccc(C(C)(C)C)cc3)[nH]n12,Train "EU_REACH: trimorpholinophosphine oxide",,4441-12-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23808/7/4/2/?documentUUID=11e8351c-1e8d-4775-8173-bb598591d607,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1COCCN1P(=O)(N2CCOCC2)N3CCOCC3,https://pubchem.ncbi.nlm.nih.gov/compound/78180,PubChem,O=P(N1CCOCC1)(N1CCOCC1)N1CCOCC1,Train "EU_REACH: 2-hydroxy-3-(prop-2-enoyloxy)propyl 2-methyl-2-propylhexanoate",,444649-70-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19415/7/4/2/?documentUUID=1543e717-cec8-4fd3-ab59-f72b49215449,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(C)(CCC)C(=O)OCC(COC(=O)C=C)O,https://pubchem.ncbi.nlm.nih.gov/compound/153372430,PubChem,C=CC(=O)OCC(O)COC(=O)C(C)(CCC)CCCC,Train "EU_REACH: 1,3-bis(2-ethylhexyl) 2-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]propanedioate",,444811-29-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/3781/7/4/2/?documentUUID=93ec83e0-58ad-4587-bc05-cce21dbbcb38,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)C(=CC1=CC(=C(C(=C1)OC)O)OC)C(=O)OCC(CC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/10163591,PubChem,CCCCC(CC)COC(=O)C(=Cc1cc(OC)c(O)c(OC)c1)C(=O)OCC(CC)CCCC,Train "AU_HCIS: Tetradecanamide, N-[3-(dimethylamino)propyl]-",,45267-19-4,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6765,,,AU_HCIS,1,CCCCCCCCCCCCCC(=O)NCCCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/170759,PubChem,CCCCCCCCCCCCCC(=O)NCCCN(C)C,Train "NZ_CCID: 2-Methylhexanoic acid",,4536-23-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/41DFFD22-9CE9-4DA5-A55E-8F6E99AB25C0,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCC(C)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/20653,PubChem,CCCCC(C)C(=O)O,Train "KR_NCIS: Pentamethylene diisocyanate; 1,5-Diisocyanatopentane;",,4538-42-5,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C(CCN=C=O)CCN=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/11948526,PubChem,O=C=NCCCCCN=C=O,Train "NZ_CCID: 3-Fluorobenzyl chloride",,456-42-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7C3F465D-985B-4935-905E-D7966B5EE684,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)F)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/9974,PubChem,Fc1cccc(CCl)c1,Train "EU_REACH: [(2R,3R,4R,5S,6S)-3,4,5-tris(acetyloxy)-6-{4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl}oxan-2-yl]methyl acetate",,461432-25-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5228/7/4/2/?documentUUID=b2791948-46e1-4d9c-90a2-a87b3bc814f4,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)COC(=O)C)OC(=O)C)OC(=O)C)OC(=O)C)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/10415783,PubChem,CCOc1ccc(Cc2cc([C@@H]3O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(C)=O)ccc2Cl)cc1,Train "EU_REACH: hydantoin",,461-72-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22662/7/4/2/?documentUUID=681bb512-22ee-4948-940e-a442478b0491,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C(=O)NC(=O)N1,https://pubchem.ncbi.nlm.nih.gov/compound/10006,PubChem,O=C1CNC(=O)N1,Train "EU_REACH: fluorobenzene",,462-06-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1885/7/4/2/?documentUUID=3ba8733e-3d90-4f5c-bc9a-0aa1d627b82f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)F,https://pubchem.ncbi.nlm.nih.gov/compound/10008,PubChem,Fc1ccccc1,Train "EU_REACH: 2-(1,3-oxazolidin-3-yl)ethyl 2-methylprop-2-enoate",,46235-93-2,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23768/7/4/2/?documentUUID=8086295f-9774-44ed-9df1-93e7e3035815,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OCCN1CCOC1,https://pubchem.ncbi.nlm.nih.gov/compound/162072,PubChem,C=C(C)C(=O)OCCN1CCOC1,Train "KR_NCIS: 4-Chlorobutanoyl chloride NZ_CCID: 4-Chlorobutyryl chloride",,4635-59-0,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4C089735-7A38-4504-AB9A-B2A66D62B3B0","NZ_CCID: Skin Irritation R PHRASE: R 35 [Company Data] Eye Irritation R PHRASE: R 35 [Company Data]",,"KR_NCIS, NZ_CCID",2,C(CC(=O)Cl)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/78370,PubChem,O=C(Cl)CCCCl,Train "EU_REACH: Dimethyl ethenylphosphonate",,4645-32-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19763/7/4/2/?documentUUID=33b2a429-0c2a-4320-86c1-4b987ad0a965,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COP(=O)(C=C)OC,https://pubchem.ncbi.nlm.nih.gov/compound/78376,PubChem,C=CP(=O)(OC)OC,Train "NZ_CCID: 2,6-Dichlorobenzoyl chloride",,4659-45-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0F224BEC-9527-4E45-8C5F-35D14D1BD27B,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=C(C(=C1)Cl)C(=O)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/78392,PubChem,O=C(Cl)c1c(Cl)cccc1Cl,Train "EU_REACH: 6-(N-methylbenzenesulfonamido)hexanoic acid",,46948-72-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11110/7/4/2/?documentUUID=c9a35ef8-5553-4b94-9a8f-9ef8585905b9,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(CCCCCC(=O)O)S(=O)(=O)C1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/117892,PubChem,CN(CCCCCC(=O)O)S(=O)(=O)c1ccccc1,Train "EU_REACH: 10-methoxy-5H-dibenzo[b,f]azepine",,4698-11-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13198/7/4/2/?documentUUID=5871a3d5-18b5-4494-b786-90c6af1a8137,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC2=CC=CC=C2NC3=CC=CC=C31,https://pubchem.ncbi.nlm.nih.gov/compound/78424,PubChem,COC1=Cc2ccccc2Nc2ccccc21,Train "EU_REACH: 2,2',2''-(1,3,5-triazinane-1,3,5-triyl)triethanol",,4719-04-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15014/7/4/2/?documentUUID=e599d108-5d4e-4062-943e-3f58c2d9b30d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1N(CN(CN1CCO)CCO)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/104556,PubChem,OCCN1CN(CCO)CN(CCO)C1,Train "EU_REACH: octylphosphonic acid NZ_CCID: Phosphonic acid, octyl-",,4724-48-5,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14433/7/4/2/?documentUUID=40a22159-5b31-4234-be9f-ef2f15e1d148 NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DB6BB842-838D-4B12-9069-71CD8D9BDEFB","EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,"EU_REACH, NZ_CCID",2,CCCCCCCCP(=O)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/78452,PubChem,CCCCCCCCP(=O)(O)O,Train "EU_REACH: (1r,4r)-4-(2,3-difluoro-4-propoxyphenyl)-4'-propyl-1,1'-bi(cyclohexane)",,473257-14-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21362/7/4/2/?documentUUID=caa3a662-0671-4d73-a322-39a77728d026,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1CCC(CC1)C2CCC(CC2)C3=C(C(=C(C=C3)OCCC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/58471750,PubChem,CCCOc1ccc(C2CCC(C3CCC(CCC)CC3)CC2)c(F)c1F,Train "EU_REACH: (1'r,4'r)-4-butyl-4'-(4-ethoxy-2,3-difluorophenyl)-1,1'-bi(cyclohexane)",,473257-15-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21378/7/4/2/?documentUUID=2d784388-24b5-4a2c-b999-c1b54f43f227,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC1CCC(CC1)C2CCC(CC2)C3=C(C(=C(C=C3)OCC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/53487172,PubChem,CCCCC1CCC(C2CCC(c3ccc(OCC)c(F)c3F)CC2)CC1,Train "EU_REACH: 2-{2-chloro-4-(methylsulfonyl)-3-[(tetrahydrofuran-2-ylmethoxy)methyl]benzoyl}cyclohexane-1,3-dione JP_CHRIP: 2-{2-Chloro-4-(methylsulfonyl)-3-[(oxolan-2-ylmethoxy)methyl]benzoyl}cyclohexane-1,3-dione; Tefuryltrione",,473278-76-1,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22220/7/4/2/?documentUUID=88ad67cb-7599-4755-9352-7547bd783f79 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0042e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 72-hour observation), no skin irritation was seen (erythema/eschar score: 0/0/0, edema score: 0/0/0) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009), REACH registration dossier (Accessed Sep. 2020), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)).",Provided,"EU_REACH, JP_CHRIP",2,CS(=O)(=O)c1ccc(C(=O)C2C(=O)CCCC2=O)c(Cl)c1COCC1CCCO1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.715.929J,J-GLOBAL,CS(=O)(=O)c1ccc(C(=O)C2C(=O)CCCC2=O)c(Cl)c1COCC1CCCO1,Train "EU_REACH: (4Z)-4-{[4-(diethylamino)phenyl]methylidene}-3-ethoxy-1-phenyl-4,5-dihydro-1H-pyrazol-5-one",,474044-10-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7810/7/4/2/?documentUUID=b90d13a8-fe26-4feb-b28e-23e2f4d2a23f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN(CC)C1=CC=C(C=C1)C=C2C(=NN(C2=O)C3=CC=CC=C3)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/68021382,PubChem,CCOC1=NN(c2ccccc2)C(=O)C1=Cc1ccc(N(CC)CC)cc1,Train "EU_REACH: 2-hydroxy-1-(4-{[4-(2-hydroxy-2-methylpropanoyl)phenyl]methyl}phenyl)-2-methylpropan-1-one",,474510-57-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5067/7/4/2/?documentUUID=3f38165e-45df-4534-a896-02b5ab2a06d3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C(=O)C1=CC=C(C=C1)CC2=CC=C(C=C2)C(=O)C(C)(C)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/22019754,PubChem,CC(C)(O)C(=O)c1ccc(Cc2ccc(C(=O)C(C)(C)O)cc2)cc1,Train "EU_REACH: 2-Hexyl-2 ‘-hydroxy-5 ‘methyldecananilide",,474754-93-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/3406/7/4/2/?documentUUID=83dc70bd-f9f9-463d-a197-6ca35d85e401,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCC(CCCCCC)C(=O)NC1=C(C=CC(=C1)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/58720637,PubChem,CCCCCCCCC(CCCCCC)C(=O)Nc1cc(C)ccc1O,Train "NZ_CCID: Ethyl chloroglyoxylate","NZ_CCID: ethyl oxalyl chloride",4755-77-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6E92B85A-0462-4977-88B8-3AB706F0A894,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCOC(=O)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/20884,PubChem,CCOC(=O)C(=O)Cl,Train "NZ_CCID: Methyl 2-chloroacetoacetate",,4755-81-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AE2A30C3-7106-41FE-86D8-63CFFAA38E06,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CC(=O)C(C(=O)OC)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/107332,PubChem,COC(=O)C(Cl)C(C)=O,Train "EU_REACH: 2-[(1S)-1-[(1R)-3,3-dimethylcyclohexyl]ethoxy]-2-methylpropyl cyclopropanecarboxylate; 2-[(1S)-1-[(1S)-3,3-dimethylcyclohexyl]ethoxy]-2-methylpropyl cyclopropanecarboxylate",,477218-42-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31599/7/4/2/?documentUUID=ce6d6a08-e071-4b8f-910f-b1ce59b39959,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C1CCCC(C1)(C)C)OC(C)(C)COC(=O)C2CC2,https://pubchem.ncbi.nlm.nih.gov/compound/12022011,PubChem,CC(OC(C)(C)COC(=O)C1CC1)C1CCCC(C)(C)C1,Train "EU_REACH: 4-methyl-4'-[(3E)-pent-3-en-1-yl]-1,1'-biphenyl",,478385-88-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5831/7/4/2/?documentUUID=ca59befc-3db2-47b4-831d-d59e6063f43a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C/C=C/CCC1=CC=C(C=C1)C2=CC=C(C=C2)C,https://pubchem.ncbi.nlm.nih.gov/compound/20727466,PubChem,C/C=C/CCc1ccc(-c2ccc(C)cc2)cc1,Train "NZ_CCID: Crotonic acid nitrile",,4786-20-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/03927C75-FA93-48B1-883A-03307CA8429E,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C/C=C/C#N,https://pubchem.ncbi.nlm.nih.gov/compound/637921,PubChem,C/C=C/C#N,Train "EU_REACH: 2-phenoxyethyl prop-2-enoate",,48145-04-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5368/7/4/2/?documentUUID=7050ce54-3924-4cd7-ae0e-20e20365cd10,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CC(=O)OCCOC1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/39485,PubChem,C=CC(=O)OCCOc1ccccc1,Train "EU_REACH: 4-(4-butylphenyl)-4'-ethyl-2,3-difluoro-1,1'-biphenyl",,486406-09-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20480/7/4/2/?documentUUID=8e8f4cb8-30b4-4dc9-8158-80e6f11081c3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC1=CC=C(C=C1)C2=C(C(=C(C=C2)C3=CC=C(C=C3)CC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/58731454,PubChem,CCCCc1ccc(-c2ccc(-c3ccc(CC)cc3)c(F)c2F)cc1,Train "NZ_CCID: Bromophenylacetic acid",,4870-65-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8DF85E60-C448-45A2-8A0C-16170429680E,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC=C(C=C1)C(C(=O)O)Br,https://pubchem.ncbi.nlm.nih.gov/compound/97919,PubChem,O=C(O)C(Br)c1ccccc1,Train "NZ_CCID: Dichloromethyl methyl ether","NZ_CCID: 1,1-dichlorodimethyl ether",4885-02-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/131760D0-A849-43F1-9F55-00EE27F040E0,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,COC(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/21004,PubChem,COC(Cl)Cl,Train "NZ_CCID: 2,5-Dimethylresorcinol",,488-87-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/39F1A456-C8C9-4C76-A2B4-E259D94E8E3A,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CC1=CC(=C(C(=C1)O)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/68103,PubChem,Cc1cc(O)c(C)c(O)c1,Train "EU_REACH: 4-Hydroxyquinazoline",,491-36-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25893/7/4/2/?documentUUID=38f830ed-54c2-4a7d-b6b3-46b36c60e5f4,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)C(=O)NC=N2,https://pubchem.ncbi.nlm.nih.gov/compound/135408753,PubChem,O=c1[nH]cnc2ccccc12,Train "NZ_CCID: 2-Phenylpropionic acid",,492-37-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F74D7CC1-794C-4B23-AD71-A3476EDEF0E8,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C1=CC=CC=C1)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/10296,PubChem,CC(C(=O)O)c1ccccc1,Train "NZ_CCID: cis-Decahydronaphthalene",,493-01-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FF5A5563-AF95-4606-A66A-B00B8B4C5C5E,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CCC2CCCCC2C1,https://pubchem.ncbi.nlm.nih.gov/compound/7044,PubChem,C1CCC2CCCCC2C1,Train "EU_REACH: 3-cyclopentyl-1H-indole-6-carboxylic acid",,494799-36-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5604/7/4/2/?documentUUID=5bbde926-7cf3-47b2-8aef-ede8eb68b47d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CCC(C1)C2=CNC3=C2C=CC(=C3)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/21874473,PubChem,O=C(O)c1ccc2c(C3CCCC3)c[nH]c2c1,Train "EU_REACH: methyl 3-cyclopentyl-1-methyl-1H-indole-6-carboxylate",,494799-38-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5766/7/4/2/?documentUUID=ce475ab8-7fee-441b-b323-90cf411e3820,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN1C=C(C2=C1C=C(C=C2)C(=O)OC)C3CCCC3,https://pubchem.ncbi.nlm.nih.gov/compound/59658510,PubChem,COC(=O)c1ccc2c(C3CCCC3)cn(C)c2c1,Train "EU_REACH: 4-amino-5-methoxy-N,2-dimethylbenzene-1-sulfonamide",,49564-57-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5755/7/4/2/?documentUUID=9da643d0-73ca-4735-9b29-b4e313343169,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1S(=O)(=O)NC)OC)N,https://pubchem.ncbi.nlm.nih.gov/compound/170791,PubChem,CNS(=O)(=O)c1cc(OC)c(N)cc1C,Train "EU_REACH: perhydroimidazo[4,5-d]imidazole-2,5-dione",,496-46-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24399/7/4/2/?documentUUID=b4392fab-3bce-4bad-87bf-c609a6242b28,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C12C(NC(=O)N1)NC(=O)N2,https://pubchem.ncbi.nlm.nih.gov/compound/62347,PubChem,O=C1NC2NC(=O)NC2N1,Train "EU_REACH: 2-hydroxy-4-methylbenzamide",,49667-22-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5080/7/4/2/?documentUUID=4be9aba2-5f93-45b8-ae2b-e2c0552986d1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)C(=O)N)O,https://pubchem.ncbi.nlm.nih.gov/compound/10534839,PubChem,Cc1ccc(C(N)=O)c(O)c1,Train "EU_REACH: 4-amino-2,5-dimethoxy-N-methylbenzene-1-sulfonamide",,49701-24-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5400/7/4/2/?documentUUID=366094a7-fa9d-4242-a60b-7ed2555b90c2,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CNS(=O)(=O)C1=C(C=C(C(=C1)OC)N)OC,https://pubchem.ncbi.nlm.nih.gov/compound/170801,PubChem,CNS(=O)(=O)c1cc(OC)c(N)cc1OC,Train "EU_REACH: N-(2,2-dimethoxyethyl)prop-2-enamide",,49707-23-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33500/7/4/2/?documentUUID=5faa7fa2-6538-4589-b667-d7c67ebd3e6b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(CNC(=O)C=C)OC,https://pubchem.ncbi.nlm.nih.gov/compound/9898899,PubChem,C=CC(=O)NCC(OC)OC,Train "EU_REACH: ethyl 2-(3-chloropyridin-2-yl)-5-oxopyrazolidine-3-carboxylate",,500011-88-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30952/7/4/2/?documentUUID=82c96e62-a017-4596-b366-440d6bdb9ffd,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1CC(=O)NN1C2=C(C=CC=N2)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/22280352,PubChem,CCOC(=O)C1CC(=O)NN1c1ncccc1Cl,Train "NZ_CCID: Benzyl chloroformate",,501-53-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/00F8CB4A-A80C-4B7B-94BB-A929908D89E9,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)COC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/10387,PubChem,O=C(Cl)OCc1ccccc1,Train "NZ_CCID: Cyclooctanone",,502-49-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DD577267-2B9E-4731-976E-6F869523A0A6,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CCCC(=O)CCC1,https://pubchem.ncbi.nlm.nih.gov/compound/10403,PubChem,O=C1CCCCCCC1,Train "EU_REACH: 1,4-dioxane-2,5-dione",,502-97-6,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20813/7/4/2/?documentUUID=d50ec996-9538-4411-b376-5c016cb08619,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C(=O)OCC(=O)O1,https://pubchem.ncbi.nlm.nih.gov/compound/65432,PubChem,O=C1COC(=O)CO1,Train "NZ_CCID: Azetidine",,503-29-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9CD60BD8-6713-4E93-94F1-199A94148232,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CNC1,https://pubchem.ncbi.nlm.nih.gov/compound/10422,PubChem,C1CNC1,Train "NZ_CCID: Trichloromethyl chloroformate",,503-38-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1C73802D-5EE9-4DC6-BF9F-D2F1E8E676DD,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(=O)(OC(Cl)(Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/10426,PubChem,O=C(Cl)OC(Cl)(Cl)Cl,Train "EU_REACH: ethyl 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxylate",,503614-91-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20591/7/4/2/?documentUUID=239340f9-263c-42ea-a727-5764dfacd595,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1=NN(C2=C1CCN(C2=O)C3=CC=C(C=C3)N4CCCCC4=O)C5=CC=C(C=C5)OC,https://pubchem.ncbi.nlm.nih.gov/compound/22240488,PubChem,CCOC(=O)c1nn(-c2ccc(OC)cc2)c2c1CCN(c1ccc(N3CCCCC3=O)cc1)C2=O,Train "NZ_CCID: Isopentanoic acid","NZ_CCID: isovaleric acid",503-74-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1D9021C2-46B2-4336-A55E-2A3E173B43A2,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)CC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/10430,PubChem,CC(C)CC(=O)O,Train "EU_REACH: 2-ethylhexyl 3-sulfanylpropanoate",,50448-95-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26266/7/4/2/?documentUUID=a260691f-bb5c-4b24-8447-d17d27e87ead,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)CCS,https://pubchem.ncbi.nlm.nih.gov/compound/92640,PubChem,CCCCC(CC)COC(=O)CCS,Train "NZ_CCID: 1,4-Diazacycloheptane",,505-66-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/341E1177-F5E7-429E-8CE0-E9552DE03258,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 34/41[CHEMWATCH]",,NZ_CCID,1,C1CNCCNC1,https://pubchem.ncbi.nlm.nih.gov/compound/68163,PubChem,C1CNCCNC1,Train "JP_CHRIP: Cyanogen chloride KR_NCIS: Cyanogen chloride","JP_CHRIP: Chlorine cyanide Chlorocyan Chlorocyanide Chlorocyanogen Cyanogen chloride ((CN)Cl)",506-77-4,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2109e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","JP_CHRIP: Although there is no concrete information, there is a description that the vapor of this substance may damage the skin (HSDB (Access on September 2014)). The subsidiary hazard for the Transport of Dangerous Goods of this substance is 8. From the above, it was classified in Category 1.",,"JP_CHRIP, KR_NCIS",2,ClC#N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.609C,J-GLOBAL,N#CCl,Train "EU_REACH: 3-(2-CHLOROETHYL)QUINAZOLINE-2,4(1H,3H)-DIONE",,5081-87-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19396/7/4/2/?documentUUID=aa38a6de-bc2e-4fe3-b056-9d7b4699f06a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)C(=O)N(C(=O)N2)CCCl,https://pubchem.ncbi.nlm.nih.gov/compound/78766,PubChem,O=c1[nH]c2ccccc2c(=O)n1CCCl,Train "NZ_CCID: 1-Chloroethyl chloroformate",,50893-53-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C6E8C92C-FFDE-49E8-A63F-ACBE63B0343A,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CC(OC(=O)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/521305,PubChem,CC(Cl)OC(=O)Cl,Train "EU_REACH: thymidine",,50-89-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15994/7/4/2/?documentUUID=4bbeefa5-dcb1-4856-98cb-8e45ffc90b81,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)O,https://pubchem.ncbi.nlm.nih.gov/compound/5789,PubChem,Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O,Train "EU_REACH: (3-chloropropyl)triethoxysilane",,5089-70-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14812/7/4/2/?documentUUID=4dfb4715-0a35-4f03-a770-4cbd445e39d1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](CCCCl)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/78771,PubChem,CCO[Si](CCCCl)(OCC)OCC,Train "EU_REACH: α-phenyl-1H-benzimidazole-2-methanol",,50-97-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29444/7/4/2/?documentUUID=8ee2d3e2-b1f8-4831-b9f0-1473882e7221,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C(C2=NC3=CC=CC=C3N2)O,https://pubchem.ncbi.nlm.nih.gov/compound/5792,PubChem,OC(c1ccccc1)c1nc2ccccc2[nH]1,Train "EU_REACH: 3-(isotridecyloxy)propan-1-amine",,50977-10-1,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12334/7/4/2/?documentUUID=029eb227-f700-42be-84a4-64e5a315d443,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCCCCCCOCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/170945,PubChem,CC(C)CCCCCCCCCCOCCCN,Train "EU_REACH: methyl (2S,4S,5R,6R)-5-acetamido-2,4-dihydroxy-6-[(2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate hydrate",,50998-13-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1295/7/4/2/?documentUUID=b96cae5d-ba6d-4a15-833a-96105a686087,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)N[C@@H]1[C@H](C[C@](O[C@H]1[C@@H]([C@@H](CO)O)O)(C(=O)OC)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/7173831,PubChem,COC(=O)[C@]1(O)C[C@H](O)[C@@H](NC(C)=O)[C@H]([C@H](O)[C@H](O)CO)O1,Train "EU_REACH: 2,2'-[(3,3'-dichlorobiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis[N-(2,4-dimethylphenyl)-3-oxobutanamide]",,5102-83-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15893/7/4/2/?documentUUID=09de5216-3156-4fc0-9636-086e3d9ce645,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)NC(=O)C(C(=O)C)N=NC2=C(C=C(C=C2)C3=CC(=C(C=C3)N=NC(C(=O)C)C(=O)NC4=C(C=C(C=C4)C)C)Cl)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/73462,PubChem,CC(=O)C(N=Nc1ccc(-c2ccc(N=NC(C(C)=O)C(=O)Nc3ccc(C)cc3C)c(Cl)c2)cc1Cl)C(=O)Nc1ccc(C)cc1C,Train "EU_REACH: 2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-7-oxo-8-oxa-3,5-dithia-4-phosphatetradecanoate 4-oxide",,51032-53-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24335/7/4/2/?documentUUID=16cb53ff-2677-416b-be10-136e3fc85d1d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCOC(=O)CSP(SCC(=O)OCCCCCC(C)C)SCC(=O)OCCCCCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/166083,PubChem,CC(C)CCCCCOC(=O)CSP(SCC(=O)OCCCCCC(C)C)SCC(=O)OCCCCCC(C)C,Train "EU_REACH: 2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether JP_CHRIP: 5-Propan-1-yl-6-(2,5,8-trioxadodecan-1-yl)-1,3-benzodioxole; Piperonyl Butoxide","JP_CHRIP: 1,3-Benzodioxole, 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl- 2-(2-Butoxyethoxy)ethyl 6-propylpiperonyl ether 3,4-(Methylenedioxy)-6-propylbenzylbutyl diethyleneglycol ether 5-2-(2-Butoxyethoxy)ethoxymethyl-6-propyl-1,3-benzodioxole alpha-2-(2-Butoxyethoxy)-ethoxy-4,5-methylenedioxy-2-propyltoluene Piperonyl butoxide",51-03-6,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10134/7/4/2/?documentUUID=0c6560f8-9e1c-4262-b23a-7d2b69f12b25 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0022e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1), (2). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 6) (OECD TG 404, GLP, 72-hour observation), 4 animals showed very slight erythema but recovered within 24 hours (erythema/eschar score: 0/0/0/0/0/0, edema score: 0/0/0/0/0/0) (EU CLH report (2019), REACH registration dossier (Accessed Aug. 2020)). (2) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 3-day observation), no edema was seen in any animal. Very slight erythema was observed after 24 hours, and no skin reactions were found after 72 hours (erythema/eschar score: 0.7/0.3/0.3) (EU CLH report (2019), REACH registration dossier (Accessed Aug. 2020)).",Provided,"EU_REACH, JP_CHRIP",2,CCCCOCCOCCOCc1cc2OCOc2cc1CCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J25.378B,J-GLOBAL,CCCCOCCOCCOCc1cc2c(cc1CCC)OCO2,Train "EU_REACH: 2,3,4,9-tetrahydro-1H-carbazol-3-one",,51145-61-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17008/7/4/2/?documentUUID=56581857-0fe7-40ab-8a46-cc7bedd2d4c7,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC2=C(CC1=O)C3=CC=CC=C3N2,https://pubchem.ncbi.nlm.nih.gov/compound/10867037,PubChem,O=C1CCc2[nH]c3ccccc3c2C1,Train "EU_REACH: 5-[(4-bromo-2,6-difluorophenyl)difluoromethoxy]-1,2,3-trifluorobenzene",,511540-64-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26607/7/4/2/?documentUUID=779c0be3-ab5d-4e33-b9fa-bf03737cff00,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(C=C(C(=C1F)F)F)OC(C2=C(C=C(C=C2F)Br)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/21049705,PubChem,Fc1cc(OC(F)(F)c2c(F)cc(Br)cc2F)cc(F)c1F,Train "EU_REACH: phenyl pent-4-enoate",,51231-09-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27392/7/4/2/?documentUUID=6fc57f3c-ff57-4b78-87ca-e06bc8c5650d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CCCC(=O)OC1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/15255467,PubChem,C=CCCC(=O)Oc1ccccc1,Train "EU_REACH: 4-anilino-3-nitro-N-phenylbenzenesulfonamide",,5124-25-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10331/7/4/2/?documentUUID=b7313918-4e9d-4255-8959-8b160a27bc54,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC3=CC=CC=C3)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/21201,PubChem,O=[N+]([O-])c1cc(S(=O)(=O)Nc2ccccc2)ccc1Nc1ccccc1,Train "EU_REACH: isopropyl 2-bromo-2-methylpropionate",,51368-55-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13797/7/4/2/?documentUUID=fb1d7782-64fa-41e4-8904-9e42066ce885,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)OC(=O)C(C)(C)Br,https://pubchem.ncbi.nlm.nih.gov/compound/2796293,PubChem,CC(C)OC(=O)C(C)(C)Br,Train "EU_REACH: dodecylphosphonic acid",,5137-70-2,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17216/7/4/2/?documentUUID=3fd7d818-6923-49ee-bd04-4e080e1e25f7,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCP(=O)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/78816,PubChem,CCCCCCCCCCCCP(=O)(O)O,Train "NZ_CCID: 1,1-Dichloroacetone",,513-88-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CF0401EC-E39F-401D-80D0-E26334A18D9F,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(=O)C(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/10567,PubChem,CC(=O)C(Cl)Cl,Train "EU_REACH: N-{5-[bis(2-methoxyethyl)amino]-2-[2-(2,6-dicyano-4-nitrophenyl)diazen-1-yl]phenyl}acetamide",,51553-03-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/9588/7/4/2/?documentUUID=a906ecfe-0076-485b-94fd-681143ff917a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)NC1=C(C=CC(=C1)N(CCOC)CCOC)N=NC2=C(C=C(C=C2C#N)[N+](=O)[O-])C#N,https://pubchem.ncbi.nlm.nih.gov/compound/165341294,PubChem,COCCN(CCOC)c1ccc(N=Nc2c(C#N)cc([N+](=O)[O-])cc2C#N)c(NC(C)=O)c1,Train "EU_REACH: pyridin-3-yl N,N-dimethylcarbamate",,51581-32-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21055/7/4/2/?documentUUID=4b3a38a9-ca42-4dad-8b38-30cdc6f25d20,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C)C(=O)OC1=CN=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/98821,PubChem,CN(C)C(=O)Oc1cccnc1,Train "JP_CHRIP: Bis(2-chloroethyl)methylamine; Nitrogen mustard","JP_CHRIP: 2,2'-Dichloro-N-methyldiethylamine 2-Chloro-N-(2-chloroethyl)-N-methylethanamine Bis(2-chloroethyl)methylamine Chlormethine Ethanamine, 2-chloro-N-(2-chloroethyl)-N-methyl- HN 2 HN2 Nitrogen mustard Nitrogen mustard (HN 2)",51-75-2,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/07-mhlw-0043e.html,"JP_CHRIP: It brings about a strong vesicant action on the skin and is corrosive (Patty 5th, 2001). As refined categorization is difficult, we determined that the substance is classified between Category 1A and 1C.",,JP_CHRIP,1,CN(CCCl)CCCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.305A,J-GLOBAL,CN(CCCl)CCCl,Train "EU_REACH: 2-(2-aminopropan-2-yl)-N-[(4-fluorophenyl)methyl]-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide",,518048-03-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/28361/7/4/2/?documentUUID=0bf809e0-592d-41d3-bf4c-529369b8a6ab,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C1=NC(=C(C(=O)N1C)O)C(=O)NCC2=CC=C(C=C2)F)N,https://pubchem.ncbi.nlm.nih.gov/compound/54721880,PubChem,Cn1c(C(C)(C)N)nc(C(=O)NCc2ccc(F)cc2)c(O)c1=O,Train "EU_REACH: triethoxy(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)silane",,51851-37-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24656/7/4/2/?documentUUID=686f2289-e401-4eed-bc61-4ef6306bba63,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](CCC(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/103991,PubChem,CCO[Si](CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)(OCC)OCC,Train "EU_REACH: (5-ethyl-1,3-dioxan-5-yl)methanol",,5187-23-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11057/7/4/2/?documentUUID=a3ae35d2-c3d8-4d4d-990d-ca71f1b9fcbe,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1(COCOC1)CO,https://pubchem.ncbi.nlm.nih.gov/compound/78860,PubChem,CCC1(CO)COCOC1,Train "EU_REACH: 3-hydroxy-4-{[2-methoxy-5-methyl-4-(methylsulfamoyl)phenyl]diazenyl}-N-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-2-naphthamide",,51920-12-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11429/7/4/2/?documentUUID=afd9cfd5-48dc-44ab-b272-6697c39de1e2,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1S(=O)(=O)NC)OC)N=NC2=C(C(=CC3=CC=CC=C32)C(=O)NC4=CC5=C(C=C4)NC(=O)N5)O,https://pubchem.ncbi.nlm.nih.gov/compound/104012,PubChem,CNS(=O)(=O)c1cc(OC)c(N=Nc2c(O)c(C(=O)Nc3ccc4[nH]c(=O)[nH]c4c3)cc3ccccc23)cc1C,Train "EU_REACH: 4-[(oxiran-2-yl)methoxy]-9H-carbazole",,51997-51-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19696/7/4/2/?documentUUID=3cd8212c-f16d-42ec-b723-8e6abc036800,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C(O1)COC2=CC=CC3=C2C4=CC=CC=C4N3,https://pubchem.ncbi.nlm.nih.gov/compound/5020710,PubChem,c1ccc2c(c1)[nH]c1cccc(OCC3CO3)c12,Train "EU_REACH: 4-amino-2,5-dimethoxy-N-phenylbenzene-1-sulfonamide",,52298-44-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5217/7/4/2/?documentUUID=55570535-2d41-4199-a57d-ea280c78d48a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC(=C(C=C1N)OC)S(=O)(=O)NC2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/104143,PubChem,COc1cc(S(=O)(=O)Nc2ccccc2)c(OC)cc1N,Train "EU_REACH: 1,3-bis[3-(dimethylamino)propyl]urea",,52338-87-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26695/7/4/2/?documentUUID=8fffcd74-c35c-4388-84fa-f7d60bfe6f29,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C)CCCNC(=O)NCCCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/104163,PubChem,CN(C)CCCNC(=O)NCCCN(C)C,Train "EU_REACH: 2-hydroxy-3-{4-[2-hydroxy-3-(prop-2-enoyloxy)propoxy]butoxy}propyl prop-2-enoate",,52408-42-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26069/7/4/2/?documentUUID=8182a2ca-566b-4d23-8a0c-71749ae45957,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CC(=O)OCC(COCCCCOCC(COC(=O)C=C)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/103631,PubChem,C=CC(=O)OCC(O)COCCCCOCC(O)COC(=O)C=C,Train "EU_REACH: 4-[3,5-difluoro-4-(trifluoromethoxy)phenyl]-3-fluoro-4'-[(1s,4r)-4-propylcyclohexyl]-1,1'-biphenyl",,524709-77-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23124/7/4/2/?documentUUID=2325e4d2-01a4-40fe-bf8c-642f221c8c07,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1CCC(CC1)C2=CC=C(C=C2)C3=CC(=C(C=C3)C4=CC(=C(C(=C4)F)OC(F)(F)F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/20736014,PubChem,CCCC1CCC(c2ccc(-c3ccc(-c4cc(F)c(OC(F)(F)F)c(F)c4)c(F)c3)cc2)CC1,Train "NZ_CCID: 1,6-Naphthalenedisulphonic acid",,525-37-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C7C50307-86F2-4D33-A746-AEBB3773836E,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC2=C(C=CC(=C2)S(=O)(=O)O)C(=C1)S(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/10676,PubChem,O=S(=O)(O)c1ccc2c(S(=O)(=O)O)cccc2c1,Train "EU_REACH: 2-[N-(2-cyanoethyl)-4-[(2,6-dichloro-4-nitrophenyl)azo]anilino]ethyl acetate",,5261-31-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20199/7/4/2/?documentUUID=447e2b8f-c84b-4853-b590-8fe49d5cafa1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)OCCN(CCC#N)C1=CC=C(C=C1)N=NC2=C(C=C(C=C2Cl)[N+](=O)[O-])Cl,https://pubchem.ncbi.nlm.nih.gov/compound/78916,PubChem,CC(=O)OCCN(CCC#N)c1ccc(N=Nc2c(Cl)cc([N+](=O)[O-])cc2Cl)cc1,Train "EU_REACH: D-Glucitol, propoxylated",,52625-13-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15106/7/4/2/?documentUUID=4120e57b-12a6-4dfd-8147-f8ae0debe5ff,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CO)COCC(C(C(C(COCCCO)OCCCO)OCCCO)OCCCO)OCCCO,https://pubchem.ncbi.nlm.nih.gov/compound/171178,PubChem,OCCCOCC(OCCCO)C(OCCCO)C(OCCCO)C(COCCCO)OCCCO,Train "EU_REACH: N-(2-carboxyethyl)-N-octyl-β-alanine",,52663-87-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23413/7/4/2/?documentUUID=726d5f67-b460-481f-baa7-2ebfbd69caca,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCN(CCC(=O)O)CCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/104276,PubChem,CCCCCCCCN(CCC(=O)O)CCC(=O)O,Train "EU_REACH: O,O,S-tris(4-aminophenyl) thiophosphate",,52664-35-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11228/7/4/2/?documentUUID=8661678d-4e9d-4b83-919d-4b8c7203d6ce,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1N)OP(=S)(OC2=CC=C(C=C2)N)OC3=CC=C(C=C3)N,https://pubchem.ncbi.nlm.nih.gov/compound/104278,PubChem,Nc1ccc(OP(=S)(Oc2ccc(N)cc2)Oc2ccc(N)cc2)cc1,Train "EU_REACH: 2,4-dioxo-3-oxatricyclo[7.3.1.0⁵,¹³]trideca-1(13),5,7,9,11-pentaene-8,10-dicarboxylic acid",,52671-72-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7325/7/4/2/?documentUUID=2199c64b-fd7c-45ca-a9d8-4db6a617cf49,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C2C(=CC=C3C2=C1C(=O)OC3=O)C(=O)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/132336,PubChem,O=C(O)c1ccc2c3c(ccc(C(=O)O)c13)C(=O)OC2=O,Train "EU_REACH: 17-(3-methoxypropyl)-6(or7)-methyl-3,10,17-triazahexacyclo[13.6.2.0²,¹.0,.0¹²,²².0¹,²³]tricosa-1(21),2,4(9),5,7,12(22),13,15(23),19-nonaene-11,16,18-trione",,52673-15-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20656/7/4/2/?documentUUID=baff9584-b6ed-4e76-b5d3-8bed09262776,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC2=C(C=C1)N3C(=N2)C4=C5C(=CC=C6C5=C(C=C4)C(=O)N(C6=O)CCCOC)C3=O,https://pubchem.ncbi.nlm.nih.gov/compound/104284,PubChem,COCCCN1C(=O)c2ccc3c(=O)n4c5ccc(C)cc5nc4c4ccc(c2c34)C1=O,Train "JP_CHRIP: 2.3-xylenol; 2,3-Dimethylphenol KR_NCIS: 2,3-Dimethylphenol NZ_CCID: Phenol, 2,3-dimethyl-","JP_CHRIP: Phenol, 2,3-dimethyl- 2,3-Xylenol KR_NCIS: 1,2-Dimethyl-3-hydroxybenzene; 1-Hydroxy-2,3-dimethylbenzene; 2,3-Xylenol; o-Xylenol; Phenol, 2,3-dimethyl-; XYLENOL NZ_CCID: 1-Hydroxy-2,3-dimethylbenzene, 2,3-Xylenol, o-Xylenol",526-75-0,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2029e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C19B6F91-12D5-4EEE-9AB5-533FAA07979E","JP_CHRIP: [Rationale for the Classification] Based on (1) and (2), it was classified in Category 1. Besides, since new data were obtained, the category was changed. [Evidence Data] (1) This substance is potentially corrosive to the skin and eyes (NICNAS IMAP (Access on August 2019)). (2) It was classified in ""Skin Corr. 1B (H314)"" in EU-CLP classification (EU CLP classification (Access on June 2019)). [Reference Data, etc.] (3) In an in vitro skin irritation test using the Human Dermal Epithelial Model (EpiDerm) according to OECD TG 439, this substance was classified as an irritant (REACH registration dossier (Access on July 2019)). NZ_CCID: Skin Irritation R PHRASE: R 34 [N-CLASS] Eye Irritation SPECIES: RESULT: Corrosive REFERENCE SOURCE: Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data. Edition 1. Sigma-Aldrich Corporation. Milwaukee, WI. 1985. p. 790, #D. [NTP]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,Cc1cccc(O)c1C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J6.663J,J-GLOBAL,Cc1cccc(O)c1C,Train "EU_REACH: N-[2-[(2-bromo-4,6-dinitrophenyl)azo]-5-(diethylamino)phenyl]acetamide",,52697-38-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20204/7/4/2/?documentUUID=cce48161-d0a1-47d3-ab14-8e7eacd4065a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN(CC)C1=CC(=C(C=C1)N=NC2=C(C=C(C=C2Br)[N+](=O)[O-])[N+](=O)[O-])NC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/104287,PubChem,CCN(CC)c1ccc(N=Nc2c(Br)cc([N+](=O)[O-])cc2[N+](=O)[O-])c(NC(C)=O)c1,Train "EU_REACH: L-xylo-hex-2-ulosonic acid",,526-98-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2059/7/4/2/?documentUUID=707cf8b1-ec2e-4ba5-8332-4403df6dcbdc,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C([C@@H]([C@H]([C@@H](C(=O)C(=O)O)O)O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/102424,PubChem,O=C(O)C(=O)[C@@H](O)[C@H](O)[C@@H](O)CO,Train "NZ_CCID: Thiophene-2-carboxylic acid chloride","NZ_CCID: 2-thiophenecarbonyl chloride",5271-67-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5E72CDD5-8DE0-4D1B-BE66-5B57BE72E85E,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CSC(=C1)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/78928,PubChem,O=C(Cl)c1cccs1,Train "NZ_CCID: 2-Furoyl chloride",,527-69-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4ADFAAB5-DDA5-4412-8390-E1F1113DF68B,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=COC(=C1)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/68242,PubChem,O=C(Cl)c1ccco1,Train "EU_REACH: N-[5-chloro-2-(methoxyacetyl)phenyl]acetamide",,52793-11-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12637/7/4/2/?documentUUID=2b1d70dd-5a10-48da-81db-02c8b1cad62b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)CC(=O)NC1=C(C=CC(=C1)Cl)OC,https://pubchem.ncbi.nlm.nih.gov/compound/98791,PubChem,COc1ccc(Cl)cc1NC(=O)CC(C)=O,Train "EU_REACH: 3,3'-{(2,5-dimethyl-1,4-phenylene)bis[imino(1,3-dioxobutane-2,1-diyl)diazene-2,1-diyl]}bis[4-chloro-N-(5-chloro-2-methylphenyl)benzamide]",,5280-80-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5928/7/4/2/?documentUUID=d327b0f2-c4e1-4f68-b69e-b64fc7ac7a4f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)Cl)NC(=O)C2=CC(=C(C=C2)Cl)N=NC(C(=O)C)C(=O)NC3=CC(=C(C=C3C)NC(=O)C(C(=O)C)N=NC4=C(C=CC(=C4)C(=O)NC5=C(C=CC(=C5)Cl)C)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/110639,PubChem,CC(=O)C(N=Nc1cc(C(=O)Nc2cc(Cl)ccc2C)ccc1Cl)C(=O)Nc1cc(C)c(NC(=O)C(N=Nc2cc(C(=O)Nc3cc(Cl)ccc3C)ccc2Cl)C(C)=O)cc1C,Train "EU_REACH: L-cysteine",,52-90-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12475/7/4/2/?documentUUID=341aa702-5506-4ea0-a5ed-6f6ab5e45f4d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C([C@@H](C(=O)O)N)S,https://pubchem.ncbi.nlm.nih.gov/compound/5862,PubChem,N[C@@H](CS)C(=O)O,Train "EU_REACH: (2R)-2-(2-chlorophenyl)-2-hydroxyacetic acid",,52950-18-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12970/7/4/2/?documentUUID=68a4e2f5-495a-45ba-9689-fcc051eaec58,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C(=C1)[C@H](C(=O)O)O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/2733641,PubChem,O=C(O)[C@H](O)c1ccccc1Cl,Train "EU_REACH: Bis-4-(hydroxybenzoyl)hydrochinone",,53201-62-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1039/7/4/2/?documentUUID=a1a0d961-086d-4e19-9b20-0d4063445120,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1C(=O)OC2=CC=C(C=C2)OC(=O)C3=CC=C(C=C3)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/11035492,PubChem,O=C(Oc1ccc(OC(=O)c2ccc(O)cc2)cc1)c1ccc(O)cc1,Train "EU_REACH: 1-[({[(tetradecyloxy)carbonyl]peroxy}carbonyl)oxy]tetradecane",,53220-22-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5940/7/4/2/?documentUUID=2aff888a-e1f8-45b2-8f3d-52b8ed8ef41e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCOC(=O)OOC(=O)OCCCCCCCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/104447,PubChem,CCCCCCCCCCCCCCOC(=O)OOC(=O)OCCCCCCCCCCCCCC,Train "EU_REACH: 1,2-bis(2-propylheptyl) benzene-1,2-dicarboxylate",,53306-54-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14145/7/4/2/?documentUUID=0feef1e5-379c-4c38-94be-be802b0bc552,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCC(CCC)COC(=O)C1=CC=CC=C1C(=O)OCC(CCC)CCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/92344,PubChem,CCCCCC(CCC)COC(=O)c1ccccc1C(=O)OCC(CCC)CCCCC,Train "NZ_CCID: 1H-Isoindole-1,3(2H)-dione, 2-(bromomethyl)-","NZ_CCID: N-(bromomethyl)phthalimide, N-Bromomethylphthalimide",5332-26-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E627C807-58FC-46D2-B6BF-9BEDB08EFA10,"NZ_CCID: Skin Irritation R-PHRASE: R 34. [Company data] Eye Irritation R-PHRASE: R 34. [Company data]",,NZ_CCID,1,C1=CC=C2C(=C1)C(=O)N(C2=O)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/79244,PubChem,O=C1c2ccccc2C(=O)N1CBr,Train "EU_REACH: 3-methoxypropan-1-amine JP_CHRIP: 3-Methoxypropylamine NZ_CCID: 3-Methoxypropylamine","JP_CHRIP: 3-methoxypropylamine",5332-73-0,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13449/7/4/2/?documentUUID=af1c6f7c-7cdb-44f6-96f3-bd5d53771b63 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0112e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5E41F732-2FED-48F4-849D-5B1939855E55","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: In the test using 6 rabbits (OECD TG404, GLP-compliant), burns were noted in all animals tested after 1 hour of patch removal. Symptoms of severe erythema were not disappeared completely in 14 days, and the PII (primary skin irritation index) was 6.67 (maximum score was 8) (ECETOC TR 66 (1995)). Based on the document, the substance was classified as Category 1. NZ_CCID: Skin Irritation R PHRASE: R 35 [Company Data] Eye Irritation R PHRASE: R 35 [Company Data]",Provided,"EU_REACH, JP_CHRIP, NZ_CCID",3,COCCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.072D,J-GLOBAL,COCCCN,Train "EU_REACH: 2-octyldodecan-1-ol",,5333-42-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5814/7/4/2/?documentUUID=58f61241-8d3f-4abf-a439-77960dc8434f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCC(CCCCCCCC)CO,https://pubchem.ncbi.nlm.nih.gov/compound/21414,PubChem,CCCCCCCCCCC(CO)CCCCCCCC,Train "EU_REACH: 2-hydroxycyclohepta-2,4,6-trien-1-one",,533-75-5,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24770/7/4/2/?documentUUID=ff2488c2-39ac-4d21-9b11-1213206d2f5f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C(=O)C=C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/10789,PubChem,O=c1cccccc1O,Train "NZ_CCID: 1,3-Dichloroacetone",,534-07-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/95E9D4FC-C483-4F44-A3CD-1973170521A0,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(C(=O)CCl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/10793,PubChem,O=C(CCl)CCl,Train "EU_REACH: pentane-1,2-diol",,5343-92-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2101/7/4/2/?documentUUID=c1fb70bd-aec9-43bb-992f-1551c54bb5e9,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC(CO)O,https://pubchem.ncbi.nlm.nih.gov/compound/93000,PubChem,CCCC(O)CO,Train "EU_REACH: 3-(diethylamino)propanenitrile",,5351-04-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19251/7/4/2/?documentUUID=4ac1d52a-f87d-4454-8450-006945293a81,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN(CC)CCC#N,https://pubchem.ncbi.nlm.nih.gov/compound/79306,PubChem,CCN(CC)CCC#N,Train "EU_REACH: ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxylate",,536759-91-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7872/7/4/2/?documentUUID=d569acfe-1f49-49fa-b577-6357b6cd530c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1=NN(C2=C1CCN(C2=O)C3=CC=C(C=C3)[N+](=O)[O-])C4=CC=C(C=C4)OC,https://pubchem.ncbi.nlm.nih.gov/compound/11711790,PubChem,CCOC(=O)c1nn(-c2ccc(OC)cc2)c2c1CCN(c1ccc([N+](=O)[O-])cc1)C2=O,Train "EU_REACH: (2E)-1,1,4,4-tetramethoxybut-2-ene; (2Z)-1,1,4,4-tetramethoxybut-2-ene",,5370-08-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10544/7/4/2/?documentUUID=27004e75-eb3c-4116-b535-e934bed2bee8,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(/C=C\C(OC)OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/5382783,PubChem,COC(/C=C\C(OC)OC)OC,Train "EU_REACH: (1S,5R)-6,8-dioxabicyclo[3.2.1]octan-4-one",,53716-82-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16252/7/4/2/?documentUUID=c20de59c-a0f0-4651-9249-58e43c22b425,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC(=O)[C@@H]2OC[C@H]1O2,https://pubchem.ncbi.nlm.nih.gov/compound/10975499,PubChem,O=C1CC[C@H]2CO[C@@H]1O2,Train "EU_REACH: 1,4-dimethyl 2-aminobenzene-1,4-dicarboxylate",,5372-81-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10651/7/4/2/?documentUUID=1ee301bb-d209-4ea1-a89b-18c13fd3d58c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1=CC(=C(C=C1)C(=O)OC)N,https://pubchem.ncbi.nlm.nih.gov/compound/79336,PubChem,COC(=O)c1ccc(C(=O)OC)c(N)c1,Train "EU_REACH: nadide",,53-84-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10862/7/4/2/?documentUUID=d9a63255-0caa-44bd-82b7-186b21220c11,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)OP(=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/5893,PubChem,NC(=O)c1ccc[n+]([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c1,Train "EU_REACH: 3-(carbamimidoylsulfanyl)propanoic acid",,5398-29-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24619/7/4/2/?documentUUID=201e1ea2-6a6b-4371-961e-68fbd30fa720,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CSC(=N)N)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/79387,PubChem,N=C(N)SCCC(=O)O,Train "EU_REACH: N-(4-fluorophenyl)-2-hydroxy-N-(propan-2-yl)acetamide",,54041-17-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5900/7/4/2/?documentUUID=7511f357-e818-4b98-9fda-81a578302a6d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)N(C1=CC=C(C=C1)F)C(=O)CO,https://pubchem.ncbi.nlm.nih.gov/compound/6452934,PubChem,CC(C)N(C(=O)CO)c1ccc(F)cc1,Train "EU_REACH: 453-570-1",,540734-22-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16947/7/4/2/?documentUUID=da0e002c-2336-400c-89e1-ee417b824b41,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H]1C=CCC([C@H]1C(=O)OC)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/12082923,PubChem,COC(=O)[C@H]1[C@H](C)C=CCC1(C)C,Train "JP_CHRIP: 1,2-Dimethylhydrazine","JP_CHRIP: SDMH",540-73-8,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-0006e.html,"JP_CHRIP: [Rationale for the Classification] Based on (1), it was classified in Category 1. [Evidence Data] (1) This substance is strongly alkaline, so it is considered to be corrosive and irritating to the skin, eyes, and mucous membranes (PATTY (6th, 2012)). [Reference Data, etc.] (2) There is a description that contact with this substance may cause irritation to the skin, eyes, and mucous membranes (HSDB (Access on June 2019)). (3) Dermal discoloration and irritation were observed in dogs, rabbits and guinea pigs on dermal exposure to this substance (ATSDR (1997)).",,JP_CHRIP,1,CNNC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.643I,J-GLOBAL,CNNC,Train "EU_REACH: dodecamethylcyclohexasiloxane",,540-97-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15811/7/4/2/?documentUUID=828f592a-f551-4b82-aa96-98d10c80aae9,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si]1(O[Si](O[Si](O[Si](O[Si](O[Si](O1)(C)C)(C)C)(C)C)(C)C)(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/10911,PubChem,C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1,Train "EU_REACH: hexamethyl-1,3,5,2,4,6-trioxatrisilinane",,541-05-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14554/7/4/2/?documentUUID=74ca7a5a-d916-4238-beb9-f1ae243aa445,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si]1(O[Si](O[Si](O1)(C)C)(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/10914,PubChem,C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O1,Train "JP_CHRIP: Ethyl chloroformate NZ_CCID: Ethoxycarbonyl chloride","JP_CHRIP: Carbonochloridic acid ethyl ester Chloroformic acid ethyl ester Ethoxycarbonyl chloride Ethyl chlorocarbonate Ethyl chloroformate NZ_CCID: Carbonochloridic acid, ethyl ester, Cathyl chloride, Chloroformic acid ethyl ester, Ethyl carbonochloridate, Ethyl chlorocarbonate, Ethyl chloroformate, Formic acid, chloro-, ethyl ester",541-41-3,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0055e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C67FA5C4-4399-4235-A750-200AE8E16057","JP_CHRIP: Based on reports of ""a strong skin irritant"" (HSDB (2003)) and ""causes severe skin burns"" (HSDB (2003)) as human health effects, and classification as C; R34 in EU classification (EU-Annex I (2009)), the substance was classified into Category 1. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CCOC(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J53.980E,J-GLOBAL,CCOC(=O)Cl,Train "NZ_CCID: Chloroacetic anhydride",,541-88-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A7246949-7604-4AC7-88D9-8D4408C18CA4,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C(C(=O)OC(=O)CCl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/10946,PubChem,O=C(CCl)OC(=O)CCl,Train "EU_REACH: 6-methyl-1,3,5-triazine-2,4-diamine",,542-02-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11626/7/4/2/?documentUUID=c3d477b9-6076-4e25-bdea-23dd5b389c6f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=NC(=NC(=N1)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/10949,PubChem,Cc1nc(N)nc(N)n1,Train "EU_REACH: propan-2-yl 3-oxobutanoate",,542-08-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12824/7/4/2/?documentUUID=80a48004-e6ef-4a1e-8c8c-a4b8e8e11c45,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)OC(=O)CC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/68329,PubChem,CC(=O)CC(=O)OC(C)C,Train "EU_REACH: 2-(undec-10-enamido)acetic acid",,54301-26-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8859/7/4/2/?documentUUID=6a8356e3-14f0-48d0-a659-94a462568e2c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CCCCCCCCCC(=O)NCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/10037355,PubChem,C=CCCCCCCCCC(=O)NCC(=O)O,Train "NZ_CCID: Succinyl dichloride","NZ_CCID: succinyl chloride",543-20-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8E08612C-7F06-48FE-AEFC-8D633553FB1E,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(CC(=O)Cl)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/10970,PubChem,O=C(Cl)CCC(=O)Cl,Train "NZ_CCID: Isobutylchlorofomate","NZ_CCID: Isobutyl Chloroformate",543-27-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/89500115-A486-40F5-B200-8F637AE97B15,"NZ_CCID: Skin Irritation R-PHRASE: R 34. [MSDS] Eye Irritation R-PHRASE: R 34. [MSDS]",,NZ_CCID,1,CC(C)COC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/62365,PubChem,CC(C)COC(=O)Cl,Train "EU_REACH: 2-ethylhexyl benzoate",,5444-75-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11596/7/4/2/?documentUUID=6dbc323d-1661-453b-a5d9-3fc4bc32aeeb,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)C1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/94310,PubChem,CCCCC(CC)COC(=O)c1ccccc1,Train "EU_REACH: 2-butoxyethyl benzoate",,5451-76-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23065/7/4/2/?documentUUID=c75d4750-0420-4862-9801-bc08a8d830d3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOCCOC(=O)C1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/79543,PubChem,CCCCOCCOC(=O)c1ccccc1,Train "EU_REACH: ethane-1,2-diyl bis(3-oxobutanoate)",,5459-04-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10689/7/4/2/?documentUUID=756f3927-2d90-43fc-b167-947872cd8876,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)CC(=O)OCCOC(=O)CC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/79566,PubChem,CC(=O)CC(=O)OCCOC(=O)CC(C)=O,Train "JP_CHRIP: Propylene glycol monoethyl ether acetate","JP_CHRIP: 1-Ethoxy-2-acetoxypropanol 1-Ethoxy-2-propanol acetate 1-Ethoxy-2-propyl acetate 2-Propanol, 1-ethoxy-, acetate 2PG1EEA",54839-24-6,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0046e.html,"JP_CHRIP: It is reported that it had a low potential of irritancy in a test with rabbits (OECD TG404, GLP) (ECETOC TR95 vol. II (2005)). And it is described that the test results showed slight erythema in two out of three animals and slight edema in one, but it could not be evidence to classify this substance as an irritant (IUCLID (2000)). Therefore, it was classified as ""Not classified"" in the Classification JIS (corresponding to Category 3 in UN GHS classification).",Provided,JP_CHRIP,1,CCOCC(C)OC(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J38.100D,J-GLOBAL,CCOCC(C)OC(C)=O,Train "NZ_CCID: Cyclohexanemethanamine, 1,3,3-trimethyl-N-(2-methylpropylidene)-5-[(2-methylpropylidene)amino]-",,54914-37-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0F97A48F-694B-4C7A-B682-4A3A954ED436,"NZ_CCID: Skin Irritation R PHRASE: R 34[CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CC(C)C=NCC1(CC(CC(C1)(C)C)N=CC(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/108265,PubChem,CC(C)C=NCC1(C)CC(N=CC(C)C)CC(C)(C)C1,Train "EU_REACH: 2-isopropyl-9H-thioxanthen-9-one",,5495-84-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24945/7/4/2/?documentUUID=89ee4e28-abf8-4cd7-a101-f6adc4be883c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C1=CC2=C(C=C1)SC3=CC=CC=C3C2=O,https://pubchem.ncbi.nlm.nih.gov/compound/79633,PubChem,CC(C)c1ccc2sc3ccccc3c(=O)c2c1,Train "EU_REACH: (1,4,5,6-tetrahydro-4,6-dioxopyrimidin-2-yl)cyanamide",,55067-10-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23973/7/4/2/?documentUUID=405d1b53-9bb9-4df2-916e-e9bf8e8a45df,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(N=C(NC1=O)NC#N)O,https://pubchem.ncbi.nlm.nih.gov/compound/246750,PubChem,N#CNc1nc(O)cc(=O)[nH]1,Train "NZ_CCID: Benzene, 1-chloro-2-(chloromethyl)-3-fluoro-",,55117-15-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B02E55D3-F4FB-4409-8FF0-B04405664011,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC(=C(C(=C1)Cl)CCl)F,https://pubchem.ncbi.nlm.nih.gov/compound/108675,PubChem,Fc1cccc(Cl)c1CCl,Train "EU_REACH: 1-(chloromethyl)-2-methylbenzene",,552-45-4,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21327/7/4/2/?documentUUID=bdf30469-2cbd-4ac4-8869-fc231d901b09,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=CC=C1CCl,https://pubchem.ncbi.nlm.nih.gov/compound/11093,PubChem,Cc1ccccc1CCl,Train "EU_REACH: 4-[(1-butyl-5-cyano-2-hydroxy-4-methyl-6-oxo-1,6-dihydropyridin-3-yl)diazenyl]-N-(2-ethylhexyl)benzenesulfonamide",,55290-62-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16345/7/4/2/?documentUUID=d4eda543-8b6b-46f8-becf-ab7125503350,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)CNS(=O)(=O)C1=CC=C(C=C1)N=NC2=C(C(=C(N(C2=O)CCCC)O)C#N)C,https://pubchem.ncbi.nlm.nih.gov/compound/108330,PubChem,CCCCC(CC)CNS(=O)(=O)c1ccc(N=Nc2c(C)c(C#N)c(O)n(CCCC)c2=O)cc1,Train "EU_REACH: 5-[(2-hydroxyethyl)amino]-2-methylphenol",,55302-96-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21638/7/4/2/?documentUUID=72ff3e96-c526-48b3-ac07-07d1963e2433,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)NCCO)O,https://pubchem.ncbi.nlm.nih.gov/compound/134396,PubChem,Cc1ccc(NCCO)cc1O,Train "EU_REACH: 3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one",,55314-16-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33471/7/4/2/?documentUUID=b6336d22-9280-45d2-b196-243a7cbed105,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C)/C=C/C(=O)C1=CN=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/5369165,PubChem,CN(C)/C=C/C(=O)c1cccnc1,Train "NZ_CCID: Acetylsalicyloyl chloride",,5538-51-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0371D7CC-5795-4C58-B816-B371C5647974,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(=O)OC1=CC=CC=C1C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/79668,PubChem,CC(=O)Oc1ccccc1C(=O)Cl,Train "AU_HCIS: Ethanedioic acid, dimethyl ester EU_REACH: dimethyl oxalate",,553-90-2,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5156 EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25766/7/4/2/?documentUUID=aa814c37-8c63-43d7-bb3b-18068359a978","EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,"AU_HCIS, EU_REACH",2,COC(=O)C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/11120,PubChem,COC(=O)C(=O)OC,Train "EU_REACH: 2,4-dichloroaniline",,554-00-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1683/7/4/2/?documentUUID=9fe60766-330f-44a1-a18b-4c11617daf16,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C=C1Cl)Cl)N,https://pubchem.ncbi.nlm.nih.gov/compound/11123,PubChem,Nc1ccc(Cl)cc1Cl,Train "EU_REACH: (2S,3S,4R)-2-aminooctadecane-1,3,4-triol",,554-62-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27327/7/4/2/?documentUUID=817df8db-6f46-4e25-b78c-8acaa1820b96,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCC[C@H]([C@H]([C@H](CO)N)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/122121,PubChem,CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO,Train "EU_REACH: 1,3-bis(octadecanoyloxy)propan-2-yl octadecanoate",,555-43-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12757/7/4/2/?documentUUID=9faef1d4-5f6a-4b66-a62f-1ce425d895f9,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCCC(=O)OCC(COC(=O)CCCCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/11146,PubChem,CCCCCCCCCCCCCCCCCC(=O)OCC(COC(=O)CCCCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCCCC,Train "EU_REACH: 2,2'-[(3,3'-dichlorobiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutanamide]",,5567-15-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16028/7/4/2/?documentUUID=b35fe108-0379-4819-aa3d-a9f969d9755b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC(=C(C=C1OC)Cl)OC)N=NC2=C(C=C(C=C2)C3=CC(=C(C=C3)N=NC(C(=O)C)C(=O)NC4=CC(=C(C=C4OC)Cl)OC)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/21733,PubChem,COc1cc(NC(=O)C(N=Nc2ccc(-c3ccc(N=NC(C(C)=O)C(=O)Nc4cc(OC)c(Cl)cc4OC)c(Cl)c3)cc2Cl)C(C)=O)c(OC)cc1Cl,Train "JP_CHRIP: 3-Methyl-2-buten-1-ol","JP_CHRIP: 3,3-Dimethylallyl alcohol Prenol Prenyl alcohol",556-82-1,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0038e.html,"JP_CHRIP: It was classified in Category 1 because the primary dermal irritation index (PDII) was 6.13, and it was judged as corrosive in a test by a 4-hour occlusive application of 0.5 mL of undiluted this substance to the rabbit skin (SIDS (2003)). Besides, it is reported that it was also judged as corrosive in another test by a 20-hour or 24-hour occlusive application of undiluted this substance to the rabbit skin (SIDS (2003)).",,JP_CHRIP,1,CC(=CCO)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J11.528B,J-GLOBAL,CC(C)=CCO,Train "EU_REACH: 2-(4-tert-butyl-3-hydroxy-2,6-dimethylphenyl)acetonitrile",,55699-10-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11381/7/4/2/?documentUUID=c41c1835-d02b-4eec-8ff2-9b01f8b03d29,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C(=C1CC#N)C)O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/108756,PubChem,Cc1cc(C(C)(C)C)c(O)c(C)c1CC#N,Train "EU_REACH: 2-ethyl-4,4-dimethylcyclohexan-1-one",,55739-89-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30121/7/4/2/?documentUUID=199b9226-5e09-4248-b23b-7fd15c84257c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1CC(CCC1=O)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/11126487,PubChem,CCC1CC(C)(C)CCC1=O,Train "JP_CHRIP: Methanesulfonyl fluoride",,558-25-8,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0166e.html,"JP_CHRIP: From the information that it is extremely destructive to tissues of skin (HSDB (2007)), it was classified in Category 1.",,JP_CHRIP,1,CS(=O)(=O)F,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J6.487D,J-GLOBAL,CS(=O)(=O)F,Train "EU_REACH: 1-[2-(2-butoxy-1-methylethoxy)-1-methylethoxy]propan-1-ol",,55934-93-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13383/7/4/2/?documentUUID=c7095db4-c017-4906-b798-cc23a834d752,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOCCCC(C)OCCOCC(C)CO,https://cactus.nci.nih.gov/chemical/structure/55934-93-5/smiles,CACTUS,CCOCCCC(C)OCCOCC(C)CO,Train "EU_REACH: (2E)-2-methyl-3-(4-methylphenyl)prop-2-en-1-ol",,56138-10-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26852/7/4/2/?documentUUID=e2e3cb19-19c4-43ca-8c58-bceb2fa3206e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)/C=C(\C)/CO,https://pubchem.ncbi.nlm.nih.gov/compound/15683411,PubChem,C/C(=C\c1ccc(C)cc1)CO,Train "JP_CHRIP: 3,3'-Iminodi(propylamine) KR_NCIS: 3,3'-Iminodi(propylamine)","JP_CHRIP: Imino-bis(3-propylamine)",56-18-8,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0188e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","JP_CHRIP: Since a solution of this substance has a pH of 12 (100 g/L, 20 degC) (GESTIS (access on Sep. 2009)) and the substance is classified into C; R35 in EU classification (EU-Annex I (access on Sep. 2009)), the substance was classified into Category 1. As relevant information, there is a report of ""moderate"" irritating in an open irritation test where 470 mg of the substance was applied to the skin of rabbits (RTECS (1999)).",,"JP_CHRIP, KR_NCIS",2,NCCCNCCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J9.891D,J-GLOBAL,NCCCNCCCN,Train "NZ_CCID: Cantharidin",,56-25-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5DC7778F-4B68-4A0B-80BA-AE8D2A1D8534,"NZ_CCID: Skin Irritation R PHRASE: R 35 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C[C@@]12[C@H]3CC[C@@H]([C@@]1(C(=O)OC2=O)C)O3,https://pubchem.ncbi.nlm.nih.gov/compound/5944,PubChem,C[C@@]12C(=O)OC(=O)[C@]1(C)[C@H]1CC[C@@H]2O1,Train "AU_HCIS: N,N'-methylenedimorpholine","AU_HCIS: Morpholine, 4,4'-methylenebis- N,N'methylenebismorpholine [formaldehyde released from N,N'-methylenebismorpholine] [MBM]",5625-90-1,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5717,,,AU_HCIS,1,C1COCCN1CN2CCOCC2,https://pubchem.ncbi.nlm.nih.gov/compound/21839,PubChem,C1CN(CN2CCOCC2)CCO1,Train "JP_CHRIP: 3-Chloro-2-methyl-1-propene","JP_CHRIP: 3-Chloro-2-methyl-1-propene 1-Propene, 3-chloro-2-methyl- 3-Chloro-2-methyl-1-propene 3-Chloro-2-methylpropene gamma-Chloroisobutylene Methallyl chloride Methyl allyl chloride",563-47-3,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0113e.html,"JP_CHRIP: It is reported to be corrosive to rabbit skin (DFGOT vol. 4 (1992)), and it is also reported to be irritating to the skin in humans (Environmental Risk Assessment for Chemical Substances Vol. 9 (Ministry of the Environment, 2011)). Therefore, it was classified in Category 1.",,JP_CHRIP,1,CC(=C)CCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.671I,J-GLOBAL,C=C(C)CCl,Train "NZ_CCID: 2-Bromopropionyl bromide",,563-76-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9E5388E5-43E4-429F-AD7C-8867292D50D3,"NZ_CCID: Skin Irritation R-PHRASE: R 34. [Chemwatch] Eye Irritation R-PHRASE: R 34/ 41. [Chemwatch]",,NZ_CCID,1,CC(C(=O)Br)Br,https://pubchem.ncbi.nlm.nih.gov/compound/79047,PubChem,CC(Br)C(=O)Br,Train "EU_REACH: 4-[[5-(anilino)carbonyl-2-methoxyphenyl]azo]-3-hydroxynaphthalene-2-carboxamide",,56396-10-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24090/7/4/2/?documentUUID=5f0943af-e22c-4bbc-b5a4-c12790c8eea4,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2)N=NC3=C(C(=CC4=CC=CC=C43)C(=O)N)O,https://pubchem.ncbi.nlm.nih.gov/compound/91836,PubChem,COc1ccc(C(=O)Nc2ccccc2)cc1N=Nc1c(O)c(C(N)=O)cc2ccccc12,Train "EU_REACH: glycine",,56-40-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14889/7/4/2/?documentUUID=1e4cdeac-7f62-4aac-850f-4aa7ff6459c8,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(C(=O)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/750,PubChem,NCC(=O)O,Train "EU_REACH: 2-propenoic acid, 2-methyl-, 4-benzoylphenyl ester",,56467-43-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22095/7/4/2/?documentUUID=5ccc383c-7a8c-4d31-b272-cc012aafba0d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OC1=CC=C(C=C1)C(=O)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/11230895,PubChem,C=C(C)C(=O)Oc1ccc(C(=O)c2ccccc2)cc1,Train "NZ_CCID: 4-(Dimethylamino) azobenzene -4'-sulphonyl chloride",,56512-49-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BBF5E72A-AB3B-45B5-8EEF-420BD5DE88DF,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CN(C)C1=CC=C(C=C1)N=NC2=CC=C(C=C2)S(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/91660,PubChem,CN(C)c1ccc(N=Nc2ccc(S(=O)(=O)Cl)cc2)cc1,Train "EU_REACH: [2-methyl-2-(2-methylpropyl)-1,3-dioxolan-4-yl]methanol",,5660-53-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/9997/7/4/2/?documentUUID=d641f04b-2087-4e8a-a386-a4d9bf2b09cd,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CC1(OCC(O1)CO)C,https://pubchem.ncbi.nlm.nih.gov/compound/21869,PubChem,CC(C)CC1(C)OCC(CO)O1,Train "EU_REACH: 4,4,13,13-tetraethoxy-3,14-dioxa-8,9-dithia-4,13-disilahexadecane",,56706-10-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14258/7/4/2/?documentUUID=eccda6cb-6f1d-45a4-8ae1-6da16abb08dc,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](CCCSSCCC[Si](OCC)(OCC)OCC)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/92506,PubChem,CCO[Si](CCCSSCCC[Si](OCC)(OCC)OCC)(OCC)OCC,Train "EU_REACH: aspartic acid",,56-84-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14876/7/4/2/?documentUUID=cab159ce-6486-43dd-b19b-6e083a2fa76d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C([C@@H](C(=O)O)N)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/5960,PubChem,N[C@@H](CC(=O)O)C(=O)O,Train "US_HSDB: GLUTAMIC ACID",,56-86-0,Cat 1,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/490,,,US_HSDB,1,C(CC(=O)O)[C@@H](C(=O)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/33032,PubChem,N[C@@H](CCC(=O)O)C(=O)O,Train "EU_REACH: cystine",,56-89-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5911/7/4/2/?documentUUID=6a3365f1-45be-43bb-ae63-b9fc3a3bdb4d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C([C@@H](C(=O)O)N)SSC[C@@H](C(=O)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/67678,PubChem,N[C@@H](CSSC[C@H](N)C(=O)O)C(=O)O,Train "EU_REACH: 3-((3,4-dicyanophenyl)sulfonyl)-N-(2-hydroxypropyl)propane-1-sulfonamide",,569316-81-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24236/7/4/2/?documentUUID=4422612f-f35c-4551-befb-57b09cb8304b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CNS(=O)(=O)CCCS(=O)(=O)C1=CC(=C(C=C1)C#N)C#N)O,https://pubchem.ncbi.nlm.nih.gov/compound/57901542,PubChem,CC(O)CNS(=O)(=O)CCCS(=O)(=O)c1ccc(C#N)c(C#N)c1,Train "EU_REACH: 3-bromo-5-chlorophenol",,56962-04-0,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1147/7/4/2/?documentUUID=42db6bdc-e3ec-4487-a652-0ecae33db95f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(C=C(C=C1Cl)Br)O,https://pubchem.ncbi.nlm.nih.gov/compound/22630180,PubChem,Oc1cc(Cl)cc(Br)c1,Train "EU_REACH: 1-(5,5-dimethylcyclohex-1-en-1-yl)pent-4-en-1-one",,56973-85-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19874/7/4/2/?documentUUID=71b6ca85-203f-43f1-b6b1-3898923bf2a0,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(CCC=C(C1)C(=O)CCC=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/92606,PubChem,C=CCCC(=O)C1=CCCC(C)(C)C1,Train "EU_REACH: 2-methyl-N-(4-sulfamoylphenyl) prop-2-enamide",,56992-87-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12879/7/4/2/?documentUUID=1214008c-6c66-4893-b633-b767eef300a3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)NC1=CC=C(C=C1)S(=O)(=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/350062,PubChem,C=C(C)C(=O)Nc1ccc(S(N)(=O)=O)cc1,Train "EU_REACH: N-carbamimidoyl-N-methylglycine",,57-00-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12796/7/4/2/?documentUUID=a1bcc0d9-7cab-45ae-93c6-5fc97e7304aa,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(CC(=O)O)C(=N)N,https://pubchem.ncbi.nlm.nih.gov/compound/586,PubChem,CN(CC(=O)O)C(=N)N,Train "JP_CHRIP: O-(2,6-dichloro-p-tolyl) O,O-dimethyl thiophosphate; Tolclofos-methyl",,57018-04-9,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0076e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1) - (3). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, occlusive, 4-hour application, 72-hour observation), all the animals showed erythema and edema after 1 hour, but all effects were fully reversible within 72 hours (erythema/eschar score: 0.7/0.3/0.7, edema score: 0.3/0/0.3) (ECHA RAC Opinion (2019), CLH Report (2018)). (2) It is reported that in a skin irritation test with rabbits (n = 6) (occlusive, 4-hour application, 7-day observation), no skin irritation reactions were seen in any animal (erythema/eschar score: 0/0/0/0/0/0, edema score: 0/0/0/0/0/0) (ECHA RAC Opinion (2019), CLH Report (2018), JMPR (1994)). (3) It is reported that in a skin irritation test with rabbits (n = 6) (semi-occlusive, 4-hour application, 72-hour observation), no skin irritation reactions were found in any animal (erythema/eschar score: 0/0/0/0/0/0, edema score: 0/0/0/0/0/0) (ECHA RAC Opinion (2019), CLH Report (2018)).",Provided,JP_CHRIP,1,COP(=S)(OC)Oc1c(Cl)cc(C)cc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.904F,J-GLOBAL,COP(=S)(OC)Oc1c(Cl)cc(C)cc1Cl,Train "EU_REACH: urea",,57-13-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16152/7/4/2/?documentUUID=46811fa1-5ff6-40b1-ad46-5b837aee2aa9,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(=O)(N)N,https://pubchem.ncbi.nlm.nih.gov/compound/1176,PubChem,NC(N)=O,Train "EU_REACH: 5,5,9,13-tetramethyl-14,16-dioxatetracyclo[11.2.1.0¹,¹⁰.0⁴,⁹]hexadecane",,57345-19-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21986/7/4/2/?documentUUID=263413d0-5b79-4d7b-a366-15bd8bbfbd2f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(CCCC2(C1CCC34C2CCC(O3)(OC4)C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/93639,PubChem,CC12CCC3C(CCC4C(C)(C)CCCC43C)(CO1)O2,Train "JP_CHRIP: Propane-1,2-diol (Propylene glycol)","JP_CHRIP: 1,2-Dihydroxypropane 1,2-Propanediol Methyl ethylene glycol Propylene glycol",57-55-6,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-meti-0003e.html,"JP_CHRIP: [Rationale for the Classification] Based on (1)-(5), it was classified as ""Not classified."" [Evidence Data] (1) There is a report that no irritation was observed when the undiluted liquid of this substance was applied to human skin for 48 hours (SIDS (2004)). (2) There is a report that no irritation was observed when the undiluted liquid of this substance was applied to the skin of six people for 2 hours (SIDS (2004)). (3) There is a report that no irritation was observed in a skin irritation test (OECD TG404) with rabbits (SIDS (2004)). (4) There is a report that no irritation was observed in a skin irritation test (the modified Draize method) with rabbits (SIDS (2004)). (5) There is a report that this substance is non irritant in a skin irritation test (EPA OPPTS 870.2400) with rabbits (EPA Pesticide RED (2006)).",Provided,JP_CHRIP,1,CC(O)CO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.918F,J-GLOBAL,CC(O)CO,Train "JP_CHRIP: 2,6-Xylenol KR_NCIS: 2,6-Xylenol NZ_CCID: 2,6-Dimethylphenol","JP_CHRIP: 2,6-Xylenol Phenol, 2,6-dimethyl- KR_NCIS: 1-Hydroxy-2,6-dimethylbenzene; 2,6-Dimethylphenol; Phenol, 2,6-dimethyl- NZ_CCID: 2,6-xylenol",576-26-1,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-meti-0026e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/82CFF4F4-A7AD-4E56-B85A-63A8D59D8301","JP_CHRIP: There are descriptions that this substance is corrosive to the skin (Environmental Risk Assessment for Chemical Substances Vol.5 (Ministry of the Environment, 2006)) and may cause chemical burns (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). There are also descriptions that topical application of this substance on the skin of rats, rabbits, and guinea pigs causes irritation and produces ulcers in the application site (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). In addition, there is a description that this substance is corrosive when applied to rabbit skin (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). From the above, this substance was classified in Category 1. In addition, this substance was classified as ""Skin. Corr. 1B H314"" in the EU CLP classification (ECHA CL Inventory (Access, October 2015)). NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,Cc1cccc(C)c1O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J43.458B,J-GLOBAL,Cc1cccc(C)c1O,Train "NZ_CCID: Chloroglyoxylic acid methyl ester","NZ_CCID: methyl oxalyl chloride",5781-53-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/900C6E31-0BEE-4332-9FA4-BCDEE52D4DBC,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,COC(=O)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/79846,PubChem,COC(=O)C(=O)Cl,Train "AU_HCIS: Phenol, 2,4-bis(1,1,3,3-tetramethylbutyl)-",,5806-72-4,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5805,,,AU_HCIS,1,CC(C)(C)CC(C)(C)C1=CC(=C(C=C1)O)C(C)(C)CC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/79870,PubChem,CC(C)(C)CC(C)(C)c1ccc(O)c(C(C)(C)CC(C)(C)C)c1,Train "JP_CHRIP: caffeine","JP_CHRIP: 1,3,7-Trimethylxanthine 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl- 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione Caffeine Methyltheobromine Methyltheophylline",58-08-2,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0136e.html,"JP_CHRIP: Since in a test using rabbits (OECD TG 404), the substance in a 50% aqueous dilution was not irritating to the skin of rabbits (irritation index was 0) (SIDS (accessed in September 2008)), it was classified into ""Not classified"".",Provided,JP_CHRIP,1,Cn1cnc2n(C)c(=O)n(C)c(=O)c12,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.330B,J-GLOBAL,Cn1c(=O)c2c(ncn2C)n(C)c1=O,Train "JP_CHRIP: Bis(2-ethylhexyl) dithiophosphate",,5810-88-8,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0205e.html,"JP_CHRIP: The substance was classified as Category 1 based on the documented case that 24-hour open-application of 0.01 mL of undiluted substance to rabbit caused necrosis, and irritation index was grade 7 by grading according to 10 ranks (maximum grade was 10) (RTECS (1997), American Industrial Hygiene Association Journal vol. 23, p.95 (1962)) by confirming the original literature.",,JP_CHRIP,1,CCCCC(CC)COP(=S)(S)OCC(CC)CCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J50.421A,J-GLOBAL,CCCCC(CC)COP(=S)(S)OCC(CC)CCCC,Train "EU_REACH: (4E,9E)-7-ethenyl-4,10-dimethyl-7-{[(E)-(pentan-2-ylidene)amino]oxy}-6,8-dioxa-5,9-diaza-7-silatrideca-4,9-diene; (4Z,9E)-7-ethenyl-4,10-dimethyl-7-{[(E)-(pentan-2-ylidene)amino]oxy}-6,8-dioxa-5,9-diaza-7-silatrideca-4,9-diene; (4Z,9Z)-7-ethenyl-4,10-dimethyl-7-{[(E)-(pentan-2-ylidene)amino]oxy}-6,8-dioxa-5,9-diaza-7-silatrideca-4,9-diene; (4Z,9Z)-7-ethenyl-4,10-dimethyl-7-{[(Z)-(pentan-2-ylidene)amino]oxy}-6,8-dioxa-5,9-diaza-7-silatrideca-4,9-diene",,58190-62-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11181/7/4/2/?documentUUID=8bff6b81-e83e-4fef-8655-2920d1013736,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC/C(=N/O[Si](O/N=C(/CCC)\C)(O/N=C(/CCC)\C)C=C)/C,https://pubchem.ncbi.nlm.nih.gov/compound/154734417,PubChem,C=C[Si](O/N=C(\C)CCC)(O/N=C(\C)CCC)O/N=C(\C)CCC,Train "NZ_CCID: N,N-Dimethylhexanamide","NZ_CCID: Hexanamide, N,N-dimethyl-",5830-30-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9D5BAA02-36C1-4B4E-8A53-6A8447C2D46B,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCC(=O)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/22084,PubChem,CCCCCC(=O)N(C)C,Train "NZ_CCID: Silane, chloro(1,1-dimethylethyl)diphenyl-","NZ_CCID: tert-Butyl-diphenylchlorosilane",58479-61-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/341BCC26-5DCA-49AC-BA20-8C02238CCE5A,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)(C)[Si](C1=CC=CC=C1)(C2=CC=CC=C2)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/94078,PubChem,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1,Train "JP_CHRIP: Theophylline","JP_CHRIP: 1,3-Dimethyl-1H-purine-2,6(3H,7H)-dione 1,3-Dimethylxanthine 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione Theophylline",58-55-9,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0023e.html,"JP_CHRIP: In a test by a 4-hour semi-occlusive application of 0.5 g of a 50% solution of this substance to the skin of three rabbits (OECD TG404), only slight erythema was observed in two animals 4 hours after the application, and no irritation symptoms were seen at observation after 24, 48, and 72 hours. And the average irritation index (PDII) was 0, and it was judged as not irritating (SIDS (2003)). Therefore, it was classified as ""Not classified.""",Provided,JP_CHRIP,1,Cn1c2nc[nH]c2c(=O)n(C)c1=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.333G,J-GLOBAL,Cn1c(=O)c2[nH]cnc2n(C)c1=O,Train "NZ_CCID: 4-Bromobenzoyl chloride",,586-75-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/690080AE-0D52-49FF-8415-55C3BCC1C71B,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1C(=O)Cl)Br,https://pubchem.ncbi.nlm.nih.gov/compound/68515,PubChem,O=C(Cl)c1ccc(Br)cc1,Train "EU_REACH: 3-cyclohexyl-1-[4-({4-[(cyclohexylcarbamoyl)amino]phenyl}methyl)phenyl]urea; 3-cyclohexyl-1-[4-({4-[(phenylcarbamoyl)amino]phenyl}methyl)phenyl]urea; 3-phenyl-1-[4-({4-[(phenylcarbamoyl)amino]phenyl}methyl)phenyl]urea",,58890-25-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/9641/7/4/2/?documentUUID=3bea48a6-e3ce-455d-9644-9e4d6f2e0acf,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CCC(CC1)NC(=O)NC2=CC=C(C=C2)CC3=CC=C(C=C3)NC(=O)NC4CCCCC4,https://pubchem.ncbi.nlm.nih.gov/compound/352756,PubChem,O=C(Nc1ccc(Cc2ccc(NC(=O)NC3CCCCC3)cc2)cc1)NC1CCCCC1,Train "EU_REACH: 7-amino-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid",,58909-56-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25483/7/4/2/?documentUUID=d3645584-42ae-4024-9598-e6d0452b13eb,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN1C(=NC(=O)C(=O)N1)SCC2=C(N3[C@@H]([C@@H](C3=O)N)SC2)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/6351062,PubChem,Cn1[nH]c(=O)c(=O)nc1SCC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1,Train "NZ_CCID: 4-Bromobenzyl bromide",,589-15-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B79CB1B1-3B2C-46C3-A7BB-D69820AE3F6D,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1CBr)Br,https://pubchem.ncbi.nlm.nih.gov/compound/68527,PubChem,BrCc1ccc(Br)cc1,Train "NZ_CCID: Bromoacetonitrile",,590-17-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A23415D2-3C91-44B1-A36E-865420FDECE5,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C(C#N)Br,https://pubchem.ncbi.nlm.nih.gov/compound/11534,PubChem,N#CCBr,Train "EU_REACH: hexadecyl 2-ethylhexanoate",,59130-69-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11691/7/4/2/?documentUUID=8a74c534-e4f2-4471-8cf1-5ff5a65d4738,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/42956,PubChem,CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC,Train "NZ_CCID: 4-Pentenoic acid",,591-80-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5E13A0D1-D98C-4867-97C0-64205419FB68,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C=CCCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/61138,PubChem,C=CCCC(=O)O,Train "EU_REACH: 6-nonyl-1,3,5-triazine-2,4-diamine",,5921-65-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24536/7/4/2/?documentUUID=3eef8de1-f5ec-4e35-a941-5d70d474f8e5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCC1=NC(=NC(=N1)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/22209,PubChem,CCCCCCCCCc1nc(N)nc(N)n1,Train "NZ_CCID: Butylchloroformate","NZ_CCID: butyl chloroformate",592-34-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D4496ED3-07D3-46B1-A4A1-F38C101D5260,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCOC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/61140,PubChem,CCCCOC(=O)Cl,Train "EU_REACH: 2-methyl-4-propyl-1,3-oxathiane",,59323-76-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12066/7/4/2/?documentUUID=ac517391-2627-4486-b003-d7f774fdb0f7,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC[C@@H]1CCO[C@@H](S1)C,https://pubchem.ncbi.nlm.nih.gov/compound/6931728,PubChem,CCC[C@@H]1CCO[C@H](C)S1,Train "NZ_CCID: Ethanesulphonyl chloride",,594-44-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0DD79180-B65D-403B-A373-5C6C727C3B1F,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCS(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/11667,PubChem,CCS(=O)(=O)Cl,Train "NZ_CCID: Ethanesulphonic acid",,594-45-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0E7599B6-2B93-49D6-88E9-E84052D903CE,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCS(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/11668,PubChem,CCS(=O)(=O)O,Train "EU_REACH: 4-(2-{4-[(diphenoxyphosphoryl)oxy]phenyl}propan-2-yl)phenyl diphenyl phosphate; 4-{2-[4-({[4-(2-{4-[(diphenoxyphosphoryl)oxy]phenyl}propan-2-yl)phenoxy](phenoxy)phosphoryl}oxy)phenyl]propan-2-yl}phenyl diphenyl phosphate",,5945-33-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5460/7/4/2/?documentUUID=3d700bf9-86c0-414a-809b-8c7f087f41d5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C1=CC=C(C=C1)OP(=O)(OC2=CC=CC=C2)OC3=CC=CC=C3)C4=CC=C(C=C4)OP(=O)(OC5=CC=CC=C5)OC6=CC=CC=C6,https://pubchem.ncbi.nlm.nih.gov/compound/9874825,PubChem,CC(C)(c1ccc(OP(=O)(Oc2ccccc2)Oc2ccccc2)cc1)c1ccc(OP(=O)(Oc2ccccc2)Oc2ccccc2)cc1,Train "EU_REACH: 4-({5-[(4-carbamoylphenyl)carbamoyl]-2-methoxyphenyl}diazenyl)-N-(5-chloro-2,4-dimethoxyphenyl)-3-hydroxy-2-naphthamide",,59487-23-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11266/7/4/2/?documentUUID=788de4ff-551e-46e8-a237-24a5df01d85d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=C(C=C(C=C1)C(=O)NC2=CC=C(C=C2)C(=O)N)N=NC3=C(C(=CC4=CC=CC=C43)C(=O)NC5=CC(=C(C=C5OC)OC)Cl)O,https://pubchem.ncbi.nlm.nih.gov/compound/62154,PubChem,COc1cc(OC)c(NC(=O)c2cc3ccccc3c(N=Nc3cc(C(=O)Nc4ccc(C(N)=O)cc4)ccc3OC)c2O)cc1Cl,Train "AU_HCIS: chlorocresol","AU_HCIS: 4- chloro-m-cresol 4- chloro-3-methylphenol Phenol, 4-chloro-3-methyl-",59-50-7,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=925,,,AU_HCIS,1,CC1=C(C=CC(=C1)O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/1732,PubChem,Cc1cc(O)ccc1Cl,Train "EU_REACH: methyl 2-amino-4-[(2,5-dichlorophenyl)carbamoyl]benzoate",,59673-82-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11487/7/4/2/?documentUUID=ba093fef-a72a-46bc-8e19-d27d391f0aad,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1=C(C=C(C=C1)C(=O)NC2=C(C=CC(=C2)Cl)Cl)N,https://pubchem.ncbi.nlm.nih.gov/compound/761588,PubChem,COC(=O)c1ccc(C(=O)Nc2cc(Cl)ccc2Cl)cc1N,Train "NZ_CCID: 2-Chlorophenyl 2,2,2-trichloroethyl chlorophosphate",,59819-52-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F06ED442-F194-4B93-A1EA-8A3F40338B8C,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC=C(C(=C1)OP(=O)(OCC(Cl)(Cl)Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/108842,PubChem,O=P(Cl)(OCC(Cl)(Cl)Cl)Oc1ccccc1Cl,Train "NZ_CCID: Bromoacetyl bromide",,598-21-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D6F838CA-5797-4C8D-B2C6-7951DB83973A,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(C(=O)Br)Br,https://pubchem.ncbi.nlm.nih.gov/compound/61147,PubChem,O=C(Br)CBr,Train "JP_CHRIP: N,N-Dimethylethylamine NZ_CCID: Ethyldimethylamine","JP_CHRIP: Dimethylethylamine; N,N-Dimethylethylamine NZ_CCID: Dimethylethylamine, Ethanamine, N,N-dimethyl-, Ethylamine, N,N-dimethyl-, Methanamine, N-ethyl-N-methyl-, N,N-Dimethylethylamine, N-Ethyldimethylamine",598-56-1,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0148e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3C666EB4-727C-48DA-9B11-7CF646ADA2ED","JP_CHRIP: Because a test using rabbits resulted in corrosive (IUCLID (2000)) and pH is 12 (20 degrees C, 50 g/L) (GESTIS (Access on No. 2011)), it was classified in Category 1. Besides, it is classified in C; R34 in EU classification (EC-JRC (ESIS) (Access on Nov. 2011)). NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,"JP_CHRIP, NZ_CCID",2,CCN(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J60.917J,J-GLOBAL,CCN(C)C,Train "NZ_CCID: 2-Bromopropionic acid",,598-72-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5B3D8315-DDEC-40B0-A955-422E1643A5F6,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C(=O)O)Br,https://pubchem.ncbi.nlm.nih.gov/compound/11729,PubChem,CC(Br)C(=O)O,Train "EU_REACH: N-butyrylalanine",,59875-04-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8167/7/4/2/?documentUUID=99bd21cd-e001-42e9-a0b5-19e1e0fec0bc,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC(=O)NC(C)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/11194480,PubChem,CCCC(=O)NC(C)C(=O)O,Train "JP_CHRIP: 2-Chloropropionic acid NZ_CCID: 2-Chloropropionic acid","JP_CHRIP: 2-Chloropropanoic acid 2-Chloropropionic acid alpha-Chloropropionic acid Propanoic acid, 2-chloro- NZ_CCID: 2-Chloropropanoic acid, Propanoic acid, 2-chloro-, Propionic acid, 2-chloro-",598-78-7,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2036e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4E340BFC-B821-4A40-9471-219F3EDFC033","JP_CHRIP: [Rationale for the Classification] It was classified in Category 1 from (1) - (3). [Evidence Data] (1) This substance was corrosive to the eye, skin, and respiratory tract, and contact with the skin or entry into the eye caused erythema, pain, and severe burns (ACGIH (7th, 2001), Environmental Risk Assessment for Chemical Substances vol. 13 (Ministry of the Environment, 2015)). (2) In a skin irritation test with rabbits on this substance, there was localized necrosis with later formation of a scab (GESTIS (Access on May 2020)). (3) The pH of this substance was < 1 (20 deg C) (GESTIS (Access on May 2020)). NZ_CCID: Skin Irritation UN #2511 UN CLASS: 8 PG III Eye Irritation R PHRASE: R 35 [Company Data] UN #2511 UN CLASS: 8 PG III",,"JP_CHRIP, NZ_CCID",2,CC(Cl)C(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J481B,J-GLOBAL,CC(Cl)C(=O)O,Train "EU_REACH: N-{4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl}-2-methylprop-2-enamide",,59941-98-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21774/7/4/2/?documentUUID=6d7bc4b0-2c57-4bca-8b61-351803224880,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=NC(=N1)NS(=O)(=O)C2=CC=C(C=C2)NC(=O)C(=C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/13787754,PubChem,C=C(C)C(=O)Nc1ccc(S(=O)(=O)Nc2nc(C)cc(C)n2)cc1,Train "NZ_CCID: 2,2,2-Trichloroethyl dichlorophosphite",,60010-51-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C515FC67-A1FE-418A-9D10-1225D7BA6CA0,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(C(Cl)(Cl)Cl)OP(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/108874,PubChem,ClP(Cl)OCC(Cl)(Cl)Cl,Train "EU_REACH: (4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexan-1-one",,60046-50-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30135/7/4/2/?documentUUID=c9ef930f-966f-4ba3-b938-0e8036baed5d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H]1C[C@H](CC(C1=O)(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/10313234,PubChem,C[C@@H]1C[C@@H](O)CC(C)(C)C1=O,Train "EU_REACH: 1-{[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl]methyl}-1H-1,2,4-triazole JP_CHRIP: 1-{[2-(2,4-Dichlorophenyl)-4-propan-1-yl-1,3-dioxolan-2-yl]methyl}-1H-1,2,4-triazole (synonym: Propiconazole)","JP_CHRIP: Propiconazole",60207-90-1,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32104/7/4/2/?documentUUID=032faff4-e536-4712-b00a-592550e06898 JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2026.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: 【分類根拠】 （１）～（３）より、区分に該当しない。 【根拠データ】 （１）ウサギ（n=3）を用いた皮膚刺激性試験（OECD TG404、GLP、閉塞、4時間適用、21日観察）において、除去1時間後、全例で軽度の紅斑が認められ、1週間後まで持続したが、3週間後には消失した。また、除去1時間後に、2匹で軽度の浮腫が認められ、うち1匹で48時間後まで持続した。皮膚一次刺激指数（PII）は1.22であった（紅斑・痂皮スコア：1/1/1、浮腫スコア：0/0/0.7）との報告がある（農薬抄録 (2015)、REACH登録情報 (Accessed Sep. 2021)）。 （２）ウサギ（n=6）を用いた皮膚刺激性試験（閉塞、24時間適用、7日観察）において、適用1日後から軽度の紅斑及び浮腫が認められたが、4日後には消失した（紅斑・痂皮スコア：1/0.7/1/0.7/1.7/1.3、浮腫スコア：0.3/0.7/1/0.3/1.3/1）との報告がある（農薬抄録 (2015)）。 （３）本物質は皮膚刺激性物質ではない（EFSA (2017)）。 【参考データ等】 （４）本物質はウサギの皮膚に対して刺激性を有する（JMPR (2004)）。 （５）2系統のウサギを用いた皮膚刺激性試験で、軽度の刺激性がみられた（食安委 農薬評価書 (2017)）。 （６）本物質は皮膚刺激性物質ではない（HSDB (Accessed Sep. 2021)）。",Provided,"EU_REACH, JP_CHRIP",2,CCCC1COC(Cn2cncn2)(O1)c1ccc(Cl)cc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J18.426H,J-GLOBAL,CCCC1COC(Cn2cncn2)(c2ccc(Cl)cc2Cl)O1,Train "EU_REACH: 4-[(4-aminophenyl)(phenyl)methyl]aniline",,603-40-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23945/7/4/2/?documentUUID=a8b3514e-9b86-4940-9a85-b8c5a533edb3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C(C2=CC=C(C=C2)N)C3=CC=C(C=C3)N,https://pubchem.ncbi.nlm.nih.gov/compound/69045,PubChem,Nc1ccc(C(c2ccccc2)c2ccc(N)cc2)cc1,Train "EU_REACH: 4-[(4-hydroxyphenyl)(pyridin-2-yl)methyl]phenol",,603-41-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11534/7/4/2/?documentUUID=e4d6ef64-c328-476a-ae53-560fcdd05a87,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=NC(=C1)C(C2=CC=C(C=C2)O)C3=CC=C(C=C3)O,https://pubchem.ncbi.nlm.nih.gov/compound/69046,PubChem,Oc1ccc(C(c2ccc(O)cc2)c2ccccn2)cc1,Train "EU_REACH: 3-benzyloxane",,60466-73-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31625/7/4/2/?documentUUID=1d53a999-337c-4142-8362-7adb3b23ceed,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC(COC1)CC2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/12284886,PubChem,c1ccc(CC2CCCOC2)cc1,Train "NZ_CCID: 5-Dimethylaminonaphthalene-1-sulphonyl chloride","NZ_CCID: dansyl chloride",605-65-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C348073E-59B8-446F-8EF7-0C57A0C8DC29,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CN(C)C1=CC=CC2=C1C=CC=C2S(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/11801,PubChem,CN(C)c1cccc2c(S(=O)(=O)Cl)cccc12,Train "EU_REACH: 1-chloro-2,3-dimethylbenzene",,608-23-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25181/7/4/2/?documentUUID=05117a6e-282a-4ddb-b842-78d4029a7b7d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C(=CC=C1)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/32884,PubChem,Cc1cccc(Cl)c1C,Train "NZ_CCID: 4-Pentynoic acid",,6089-09-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F4059E50-8DD3-4264-93E3-68E07F9271CB,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C#CCCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/22464,PubChem,C#CCCC(=O)O,Train "EU_REACH: (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propanocyclopenta[8]annulen-8-yl[(methylsulfonyl)oxy]acetate",,60924-38-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1391/7/4/2/?documentUUID=1d4d37c5-9f0b-46dc-8c6f-417cadbbb176,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H]1CC[C@]23CCC(=O)[C@@H]2[C@]1([C@H](C[C@]([C@@H]([C@H]3C)O)(C)C=C)OC(=O)COS(=O)(=O)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/71307485,PubChem,C=C[C@@]1(C)C[C@H](OC(=O)COS(C)(=O)=O)[C@@]2(C)[C@H](C)CC[C@@]3(CCC(=O)[C@@H]32)[C@H](C)[C@H]1O,Train "NZ_CCID: 2-Chlorobenzoyl chloride",,609-65-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F814D8ED-809B-44E2-B356-A1A7510429EC,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)C(=O)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/69110,PubChem,O=C(Cl)c1ccccc1Cl,Train "NZ_CCID: 2-Iodobenzoyl chloride",,609-67-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8BD3D388-99FD-4EAC-A304-597A10F19250,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)C(=O)Cl)I,https://pubchem.ncbi.nlm.nih.gov/compound/69112,PubChem,O=C(Cl)c1ccccc1I,Train "NZ_CCID: 2-Nitrobenzoyl chloride",,610-14-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/14D42FAC-28F8-4DD6-AD50-1F66E57B38BD,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC=C(C(=C1)C(=O)Cl)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/11875,PubChem,O=C(Cl)c1ccccc1[N+](=O)[O-],Train "NZ_CCID: 2,4-Dinitrobenzyl chloride",,610-57-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/702BDEBA-3ACF-48F1-BE04-6FF47D699DD2,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])CCl,https://pubchem.ncbi.nlm.nih.gov/compound/69125,PubChem,O=[N+]([O-])c1ccc(CCl)c([N+](=O)[O-])c1,Train "JP_CHRIP: 2,4-Dichloro-1-nitrobenzene","JP_CHRIP: 2,4-Dichloronitrobenzene 2,4-dichloronitrobenzene Benzene, 2,4-dichloro-1-nitro-",611-06-3,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-meti-0075e.html,"JP_CHRIP: Based on descriptions ""Slightly irritating"" (SIDS (1996)) in the patch test with rabbits and ""Slightly irritating"" (IUCLID (2000)) in the skin irritation/corrosion test (OECD TG 404, GLP), it was classified into ""Not classified"".",Provided,JP_CHRIP,1,[O-][N+](=O)c1ccc(Cl)cc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.081H,J-GLOBAL,O=[N+]([O-])c1ccc(Cl)cc1Cl,Train "NZ_CCID: 2-Chlorobenzyl bromide",,611-17-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9B351CB9-014A-42BB-8D23-CE73E7CE3D35,"NZ_CCID: Skin Irritation R PHRASE: R 41 [CHEMWATCH] Eye Irritation R PHRASE: R 34 [CHEMWATCH]",,NZ_CCID,1,C1=CC=C(C(=C1)CBr)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/11905,PubChem,Clc1ccccc1CBr,Train "EU_REACH: 2-acetyl-1H,2H,3H,4H,6H,7H,11bH-pyrazino[2,1-a]isoquinolin-4-one",,61196-40-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30142/7/4/2/?documentUUID=7d5130cc-06da-4f0d-88b8-c761ee23da63,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)N1CC2C3=CC=CC=C3CCN2C(=O)C1,https://pubchem.ncbi.nlm.nih.gov/compound/13063820,PubChem,CC(=O)N1CC(=O)N2CCc3ccccc3C2C1,Train "EU_REACH: [(2R,4R)-2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methyl benzoate",,61397-56-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24206/7/4/2/?documentUUID=79c23041-3e52-4153-a160-f33639e0948c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1[C@@H](O[C@@](O1)(CBr)C2=C(C=C(C=C2)Cl)Cl)COC(=O)C3=CC=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/1390983,PubChem,O=C(OC[C@H]1CO[C@](CBr)(c2ccc(Cl)cc2Cl)O1)c1ccccc1,Train "EU_REACH: (Z)-hex-3-enyl (Z)-hex-3-enoate",,61444-38-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11788/7/4/2/?documentUUID=ad650677-0685-431d-9c59-61b72e4230ad,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC/C=C\CCOC(=O)C/C=C\CC,https://pubchem.ncbi.nlm.nih.gov/compound/6435882,PubChem,CC/C=C\CCOC(=O)C/C=C\CC,Train "EU_REACH: 2-hydroxybenzimidazole",,615-16-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1876/7/4/2/?documentUUID=81bfde42-bf03-454b-8ea8-5c5b46e58009,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)NC(=O)N2,https://pubchem.ncbi.nlm.nih.gov/compound/11985,PubChem,O=c1[nH]c2ccccc2[nH]1,Train "EU_REACH: 2,2-bis(methylthio)propane",,6156-18-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30186/7/4/2/?documentUUID=90165d62-9c45-43f1-b9f1-556abfcefaef,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1NC(=S)NC2=CC=C(C=C2)S(=O)(=O)N)F,https://pubchem.ncbi.nlm.nih.gov/compound/730546,PubChem,NS(=O)(=O)c1ccc(NC(=S)Nc2ccc(F)cc2)cc1,Train "EU_REACH: 2-methylpropyl-(R)-2-hydroxypropanoate",,61597-96-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17048/7/4/2/?documentUUID=7233fa5d-6aa9-4dea-b7ee-f3fc8c5326bc,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@H](C(=O)OCC(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/10486989,PubChem,CC(C)COC(=O)[C@@H](C)O,Train "EU_REACH: pyrrolidin-2-one",,616-45-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14900/7/4/2/?documentUUID=5fd1a28e-c0b4-442a-a60a-c3575137ec53,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC(=O)NC1,https://pubchem.ncbi.nlm.nih.gov/compound/12025,PubChem,O=C1CCCN1,Train "NZ_CCID: 1-Methylimidazole",,616-47-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DA4F367E-F23D-4BC9-9F09-0023B04783D2,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CN1C=CN=C1,https://pubchem.ncbi.nlm.nih.gov/compound/1390,PubChem,Cn1ccnc1,Train "EU_REACH: 2,4,6,8,10-pentamethyl-1,3,5,7,9,2,4,6,8,10-pentaoxapentasilecane",,6166-86-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15795/7/4/2/?documentUUID=5919d62b-529c-4390-9f20-0c9adff8db23,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si]1O[Si](O[Si](O[Si](O[Si](O1)C)C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6327588,PubChem,C[Si]1O[Si](C)O[Si](C)O[Si](C)O[Si](C)O1,Train "NZ_CCID: 2-Aminopropanol","NZ_CCID: DL-2-Amino-1-propanol, DL-alaninol",6168-72-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B09112CF-7FE8-4FFB-A043-80DC0D4B1D19,"NZ_CCID: Skin Irritation R-PHRASE: R 34. [Company data] Eye Irritation R-PHRASE: R 34. [Company data]",,NZ_CCID,1,CC(CO)N,https://pubchem.ncbi.nlm.nih.gov/compound/5126,PubChem,CC(N)CO,Train "EU_REACH: (11Z)-10-octyl-11-octylideneicosanedioic acid; 8-[1-(7-carboxyheptyl)-5,6-dipentyl-1,2,4a,5,6,8a-hexahydronaphthalen-2-yl]octanoic acid; 9-[2-(8-carboxyoctyl)-6-[(1E)-hept-1-en-1-yl]-5-pentylcyclohex-3-en-1-yl]nonanoic acid; 9-[6-(8-carboxyoctyl)-2-[(1E)-hept-1-en-1-yl]-3-pentylphenyl]nonanoic acid",,61788-89-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16133/7/4/2/?documentUUID=7c527504-bda8-4d2a-b7fa-0448abc85043,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCC(CCCCCCCCC(=O)O)C(CCCCCCCC(=O)O)CC/C=C\CCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/22833342,PubChem,CCCCC/C=C\CCC(CCCCCCCC(=O)O)C(CCCCCCCC)CCCCCCCCC(=O)O,Train "AU_HCIS: Amines, coco alkyldimethyl NZ_CCID: Amines, coco alkyldimethyl",,61788-93-0,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5004 NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/39138975-DCE7-4CFE-A91F-48A52CF50E69","NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,"AU_HCIS, NZ_CCID",2,CC(C)(C)OC(=O)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/312724,PubChem,CN(C)C(=O)OC(C)(C)C,Train "NZ_CCID: Furfurylamine",,617-89-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CA1211EC-86E1-4672-A3AF-E48EA5F50C57,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=COC(=C1)CN,https://pubchem.ncbi.nlm.nih.gov/compound/3438,PubChem,NCc1ccco1,Train "EU_REACH: 2-{2-[(8Z)-heptadec-8-en-1-yl]-4,5-dihydro-1H-imidazol-1-yl}ethan-1-ol; 2-{2-[(8Z)-heptadec-8-en-1-yl]-4,5-dihydro-1H-imidazol-1-yl}ethyl (9Z)-octadec-9-enoate",,61791-39-7,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5449/7/4/2/?documentUUID=0d91ab2b-640f-4fe8-9412-0a57c858a6a8,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CN(C=N1)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/155133,PubChem,OCCN1C=NCC1,Train "EU_REACH: (2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile",,61826-76-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27665/7/4/2/?documentUUID=1c7b1d95-04dd-4866-bca7-42f0f963f5ad,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)OC2=CC=CC(=C2)[C@@H](C#N)O,https://pubchem.ncbi.nlm.nih.gov/compound/9837437,PubChem,N#C[C@@H](O)c1cccc(Oc2ccccc2)c1,Train "NZ_CCID: Benzoyl bromide",,618-32-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BC116D4D-F293-4722-BBC7-39D1C3D807C9,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)C(=O)Br,https://pubchem.ncbi.nlm.nih.gov/compound/12056,PubChem,O=C(Br)c1ccccc1,Train "NZ_CCID: 1-Phenylethylamine","NZ_CCID: DL-1-Phenylethylamine",618-36-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/76BB4E2D-9E04-4051-B43B-A2E1181AFCBC,"NZ_CCID: Skin Irritation R-PHRASE: R 34. [Company data] Eye Irritation R-PHRASE: R 34. [Company data]",,NZ_CCID,1,CC(C1=CC=CC=C1)N,https://pubchem.ncbi.nlm.nih.gov/compound/7408,PubChem,CC(N)c1ccccc1,Train "NZ_CCID: 3-Chlorobenzoyl chloride",,618-46-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B02EB081-8F02-4776-8DEC-27C84F2E1986,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)Cl)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/69252,PubChem,O=C(Cl)c1cccc(Cl)c1,Train "EU_REACH: 2-ethylhexyl 2-cyano-3,3-diphenylacrylate",,6197-30-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14858/7/4/2/?documentUUID=0ba6c8d0-e0f5-42b6-b4d7-14d3aedc2f22,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)C(=C(C1=CC=CC=C1)C2=CC=CC=C2)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/22571,PubChem,CCCCC(CC)COC(=O)C(C#N)=C(c1ccccc1)c1ccccc1,Train "EU_REACH: ß-D-Ribofuranose, 5-deoxy-, triacetate (6CI,9CI)",,62211-93-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5849/7/4/2/?documentUUID=943258ba-8892-445c-b8d8-840478146b84,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H]1[C@H]([C@H]([C@@H](O1)OC(=O)C)OC(=O)C)OC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/11821332,PubChem,CC(=O)O[C@@H]1O[C@H](C)[C@@H](OC(C)=O)[C@H]1OC(C)=O,Train "JP_CHRIP: p-Nitrobenzoic acid","JP_CHRIP: p-nitrobenzoic acid para-Carboxynitrobenzene para-Nitrobenzoic acid",62-23-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-2052e.html,"JP_CHRIP: It was classified as ""Not classified"" because it is reported that there was no irritation in a test with rabbits (OECD TG 404) (IUCLID (2000)).",Provided,JP_CHRIP,1,OC(=O)c1ccc(cc1)[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.346I,J-GLOBAL,O=C(O)c1ccc([N+](=O)[O-])cc1,Train "NZ_CCID: Benzoic acid, 4-(bromomethyl)-",,6232-88-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/000DCBF7-A211-4F62-8363-196694567F43,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC(=CC=C1CBr)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/22599,PubChem,O=C(O)c1ccc(CBr)cc1,Train "EU_REACH: N-pentan-2-ylidenehydroxylamine",,623-40-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14551/7/4/2/?documentUUID=47fd4ebd-9940-43de-bf36-045ba84072e8,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC(=NO)C,https://pubchem.ncbi.nlm.nih.gov/compound/136433,PubChem,CCCC(C)=NO,Train "NZ_CCID: Ethyl cyanoformate",,623-49-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/837F908F-9B9B-4510-84E9-8809C49F44B3,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCOC(=O)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/69336,PubChem,CCOC(=O)C#N,Train "NZ_CCID: 3-Chloropropionyl chloride",,625-36-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7E95DD00-969C-4EEB-B51D-0F6E697E088E,"NZ_CCID: Skin Irritation R PHRASE: R 35 [Company Data] Eye Irritation R PHRASE: R 35 [Company Data]",,NZ_CCID,1,C(CCl)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/69364,PubChem,O=C(Cl)CCCl,Train "AU_HCIS: methoxyacetic acid JP_CHRIP: methoxyacetic acid NZ_CCID: Methoxyacetic acid","AU_HCIS: Acetic acid, methoxy- JP_CHRIP: Acetic acid, 2-methoxy- NZ_CCID: 2-Methoxyacetic acid, Acetic acid, methoxy-, Methoxyethanoic acid",625-45-6,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=2863 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0122e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/00799901-1D93-453D-825A-2EDEB849DAFB","JP_CHRIP: Since it is documented that the substance was corrosive to rabbit skin (ECETOC TR95 vol. 2 (1995)), its pH value was 1.6 (100 g/L) (GESTIS (accessed in August 2008)), and it is rated R34 in the EU classification, the substance was classified into Category 1. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,COCC(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J502I,J-GLOBAL,COCC(=O)O,Train "NZ_CCID: 4-Methylpiperidine",,626-58-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A66333B3-6623-4742-BD78-98CEAFD99D28,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC1CCNCC1,https://pubchem.ncbi.nlm.nih.gov/compound/69381,PubChem,CC1CCNCC1,Train "JP_CHRIP: 1-Methylpiperidine NZ_CCID: Piperidine, 1-methyl-","JP_CHRIP: N-methylpiperidine NZ_CCID: 1-Methylpiperidine, N-Methylpiperidine",626-67-5,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0205e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/930EF764-78B5-40AD-8F00-CDACF97BF175","JP_CHRIP: Since the substance has a pH of 12 (100 g/L, 20 degC) (GESTIS (access on Sep. 2009)), the substance was classified into Category 1. NZ_CCID: Skin Irritation UN CLASS: 8, PG II Eye Irritation UN CLASS: 8, PG II",,"JP_CHRIP, NZ_CCID",2,CN1CCCCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J39.106I,J-GLOBAL,CN1CCCCC1,Train "NZ_CCID: Ethoxyacetic acid","NZ_CCID: Acetic acid, ethoxy-",627-03-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2FB64DD9-E0CF-41D8-A828-7A2F751FE90A,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCOCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/12301,PubChem,CCOCC(=O)O,Train "EU_REACH: 4'-chloro-2-nitrobiphenyl",,6271-80-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5379/7/4/2/?documentUUID=cb0bc74d-024d-4c2e-bcc9-277c3ee835f6,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C(=C1)C2=CC=C(C=C2)Cl)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/235549,PubChem,O=[N+]([O-])c1ccccc1-c1ccc(Cl)cc1,Train "NZ_CCID: Fumaryl chloride",,627-63-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F1B7B8CC-2A1D-4C9C-81A8-55192FD9ED4C,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(=C/C(=O)Cl)\C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/5325504,PubChem,O=C(Cl)/C=C/C(=O)Cl,Train "EU_REACH: 1,4-dimethyl 2,5-dioxocyclohexane-1,4-dicarboxylate",,6289-46-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1907/7/4/2/?documentUUID=48d8556f-08c6-4bcd-9b18-2fe9c5c219e0,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1CC(=O)C(CC1=O)C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/94866,PubChem,COC(=O)C1CC(=O)C(C(=O)OC)CC1=O,Train "EU_REACH: N-cyclohexyl-N-ethylcarbamoyl chloride",,62899-75-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12832/7/4/2/?documentUUID=1644b99c-95e8-463d-aa24-63fa6bf90526,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN(C1CCCCC1)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/11332952,PubChem,CCN(C(=O)Cl)C1CCCCC1,Train "KR_NCIS: 3-Ethoxypropylamine","KR_NCIS: 3-Ethoxy-1-propanamine; 3-Ethoxy-1-propylamine; Propanolamine ethyl ether; 3-Ethoxypropanamine; 3-Ethoxypropylamine; 3-Ethoxypropan-1-amine",6291-85-6,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCOCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/22720,PubChem,CCOCCCN,Train "EU_REACH: 1-(4-methoxy-2,3,6-trimethylphenyl)but-3-en-2-one",,62924-31-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23264/7/4/2/?documentUUID=e96ae529-f440-4efc-adca-e7c34fe0d389,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C(=C1/C=C/C(=O)C)C)C)OC,https://pubchem.ncbi.nlm.nih.gov/compound/762510,PubChem,COc1cc(C)c(/C=C/C(C)=O)c(C)c1C,Train "EU_REACH: 1-(octadecyloxy)octadecane",,6297-03-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10944/7/4/2/?documentUUID=daa346a1-fc4a-4c5b-9219-2ba387584a39,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/80526,PubChem,CCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCC,Train "EU_REACH: (4-ethylphenyl)boronic acid",,63139-21-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24116/7/4/2/?documentUUID=c1b7bee5-568b-4d8d-a8ee-e9dc4a694f8c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,B(C1=CC=C(C=C1)CC)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/2734352,PubChem,CCc1ccc(B(O)O)cc1,Train "EU_REACH: 1,1,2-trimethyl-3-(4-sulfobutyl)-1H-benzo[e]indol-3-ium",,63149-24-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29957/7/4/2/?documentUUID=1c810e17-3736-4cb1-a639-e58c7358ec43,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=[N+](C2=C(C1(C)C)C3=CC=CC=C3C=C2)CCCCS(=O)(=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/113092,PubChem,CC1=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c2C1(C)C,Train "EU_REACH: 2,4,6-tris(propan-2-yl)benzene-1,3-diamine",,6318-09-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11445/7/4/2/?documentUUID=7190deb7-65e4-438c-bc1a-fc1a6151839b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C1=CC(=C(C(=C1N)C(C)C)N)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/231851,PubChem,CC(C)c1cc(C(C)C)c(N)c(C(C)C)c1N,Train "EU_REACH: 2-amino-4,5-dichlorobenzene-1-sulfonic acid",,6331-96-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1565/7/4/2/?documentUUID=b93489de-5f57-4146-9310-d04819d91c5a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(C(=CC(=C1Cl)Cl)S(=O)(=O)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/235712,PubChem,Nc1cc(Cl)c(Cl)cc1S(=O)(=O)O,Train "EU_REACH: N,N,N',N'-tetrakis(2-hydroxyethyl)hexanediamide",,6334-25-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19275/7/4/2/?documentUUID=2a6bf2b6-956e-4bdb-827e-4d263ee8fae6,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CCC(=O)N(CCO)CCO)CC(=O)N(CCO)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/95283,PubChem,O=C(CCCCC(=O)N(CCO)CCO)N(CCO)CCO,Train "EU_REACH: 1,3-diethyl 2-({4-[3-ethoxy-2-(ethoxycarbonyl)-3-oxoprop-1-en-1-yl]phenyl}methylidene)propanedioate",,6337-43-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17460/7/4/2/?documentUUID=f06124d6-3e08-4d40-8f37-6503c9044068,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C(=CC1=CC=C(C=C1)C=C(C(=O)OCC)C(=O)OCC)C(=O)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/95823,PubChem,CCOC(=O)C(=Cc1ccc(C=C(C(=O)OCC)C(=O)OCC)cc1)C(=O)OCC,Train "AU_HCIS: Phenol, 4-methyl-2,6-dinonyl-",,63451-44-5,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5796,,,AU_HCIS,1,CCCCCCCCCC1=CC(=CC(=C1O)CCCCCCCCC)C,https://pubchem.ncbi.nlm.nih.gov/compound/113237,PubChem,CCCCCCCCCc1cc(C)cc(CCCCCCCCC)c1O,Train "EU_REACH: 4-methyl-2-(2-methylpropyl)oxan-4-ol",,63500-71-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14480/7/4/2/?documentUUID=1ecdbdcf-6118-41dd-88a7-308e75649af9,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CC1CC(CCO1)(C)O,https://pubchem.ncbi.nlm.nih.gov/compound/3017432,PubChem,CC(C)CC1CC(C)(O)CCO1,Train "EU_REACH: 2-[(2-methoxy-4-nitrophenyl)diazenyl]-N-(2-methoxyphenyl)-3-oxobutanamide",,6358-31-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15183/7/4/2/?documentUUID=18946fb5-4fdb-449f-a96e-2bf7720eeb3d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC=CC=C1OC)N=NC2=C(C=C(C=C2)[N+](=O)[O-])OC,https://pubchem.ncbi.nlm.nih.gov/compound/22829,PubChem,COc1cc([N+](=O)[O-])ccc1N=NC(C(C)=O)C(=O)Nc1ccccc1OC,Train "EU_REACH: 2,2'-[(3,3'-dichlorobiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis[N-(4-methylphenyl)-3-oxobutanamide]",,6358-37-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13809/7/4/2/?documentUUID=89a1e7e4-dffb-406c-bbe3-85f8ec6390e7,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)NC(=O)C(C(=O)C)N=NC2=C(C=C(C=C2)C3=CC(=C(C=C3)N=NC(C(=O)C)C(=O)NC4=CC=C(C=C4)C)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/110824,PubChem,CC(=O)C(N=Nc1ccc(-c2ccc(N=NC(C(C)=O)C(=O)Nc3ccc(C)cc3)c(Cl)c2)cc1Cl)C(=O)Nc1ccc(C)cc1,Train "EU_REACH: 4-chloro-2,5-dimethoxyaniline",,6358-64-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1982/7/4/2/?documentUUID=bb847702-328b-4ae5-9c1f-1a3262ec5af0,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC(=C(C=C1N)OC)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/22833,PubChem,COc1cc(Cl)c(OC)cc1N,Train "EU_REACH: 2-[2-(3,3'-dichloro-4'-{2-[2-oxo-1-(phenylcarbamoyl)propyl]diazen-1-yl}-[1,1'-biphenyl]-4-yl)diazen-1-yl]-3-oxo-N-phenylbutanamide",,6358-85-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15824/7/4/2/?documentUUID=e6862f76-d05d-4361-858b-38996f9c8858,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC=CC=C1)N=NC2=C(C=C(C=C2)C3=CC(=C(C=C3)N=NC(C(=O)C)C(=O)NC4=CC=CC=C4)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/186342,PubChem,CC(=O)C(N=Nc1ccc(-c2ccc(N=NC(C(C)=O)C(=O)Nc3ccccc3)c(Cl)c2)cc1Cl)C(=O)Nc1ccccc1,Train "EU_REACH: diethyl 4,4'-[(3,3'-dichlorobiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis(5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylate)",,6358-87-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11113/7/4/2/?documentUUID=11653206-0d0c-4c50-ac7f-50e29872aec0,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1=NN(C(=O)C1N=NC2=C(C=C(C=C2)C3=CC(=C(C=C3)N=NC4C(=NN(C4=O)C5=CC=CC=C5)C(=O)OCC)Cl)Cl)C6=CC=CC=C6,https://pubchem.ncbi.nlm.nih.gov/compound/95076,PubChem,CCOC(=O)C1=NN(c2ccccc2)C(=O)C1N=Nc1ccc(-c2ccc(N=NC3C(=O)N(c4ccccc4)N=C3C(=O)OCC)c(Cl)c2)cc1Cl,Train "NZ_CCID: Pyridine-3-sulphonic acid","NZ_CCID: 3-pyridinesulfonic acid",636-73-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6644E58D-3F6F-4786-A053-901311E7AB84,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CN=C1)S(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/69468,PubChem,O=S(=O)(O)c1cccnc1,Train "EU_REACH: 1-(4-methoxyphenyl)-2-[(3-methoxyphenyl)sulfanyl]ethan-1-one",,63675-73-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8584/7/4/2/?documentUUID=46cf7090-9525-4489-95a3-e6b704f66fb3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC=C(C=C1)C(=O)CSC2=CC=CC(=C2)OC,https://pubchem.ncbi.nlm.nih.gov/compound/10108176,PubChem,COc1ccc(C(=O)CSc2cccc(OC)c2)cc1,Train "KR_NCIS: 4-Mercaptophenol",,637-89-8,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C1=CC(=CC=C1O)S,https://pubchem.ncbi.nlm.nih.gov/compound/240147,PubChem,Oc1ccc(S)cc1,Train "NZ_CCID: Ethyl 4-chloroacetoacetate",,638-07-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/47ACF8C8-D7FD-41C6-BD72-8049A3E848A2,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCOC(=O)CC(=O)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/69484,PubChem,CCOC(=O)CC(=O)CCl,Train "EU_REACH: pentanoyl chloride KR_NCIS: Pentanoyl chloride NZ_CCID: Pentanoyl chloride","NZ_CCID: valeryl chloride",638-29-9,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13405/7/4/2/?documentUUID=581a0611-c4a1-417c-ab5b-58a76304d0da KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/02DC9D69-4BF4-4DD2-8A50-1AFA33594879","EU_REACH: Experimental study (OECD TG 404, GLP) NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",Provided,"EU_REACH, KR_NCIS, NZ_CCID",3,CCCCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/61186,PubChem,CCCCC(=O)Cl,Train "EU_REACH: 3,3',5,5'-tetra-tert-butyl-[1,1'-biphenyl]-2,2'-diol",,6390-69-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8588/7/4/2/?documentUUID=847acff3-7edb-47bc-81d1-6a072c21791f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1=CC(=C(C(=C1)C(C)(C)C)O)C2=C(C(=CC(=C2)C(C)(C)C)C(C)(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/80808,PubChem,CC(C)(C)c1cc(-c2cc(C(C)(C)C)cc(C(C)(C)C)c2O)c(O)c(C(C)(C)C)c1,Train "JP_CHRIP: beta-Phenylethylamine; Phenethylamine NZ_CCID: 2-Phenylethylamine US_HSDB: 2-Phenylethylamine","JP_CHRIP: 2-phenylethylamine NZ_CCID: phenethylamine",64-04-0,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0169e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/73A60AF8-AF34-4B5A-9AEA-2FA6EDD93455 US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/3526","JP_CHRIP: The substance was classified as Category 1 based on physicochemical property of pH = 11.5 (GESTIS (Access on Oct. 2010)). As relevant notes, there was the information that the substance caused skin irritation in the human exposure study (HSDB (2003)). NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,NCCc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.833J,J-GLOBAL,NCCc1ccccc1,Train "EU_REACH: 1,4-diamino-2,3-diphenoxyanthraquinone",,6408-72-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23201/7/4/2/?documentUUID=57e87450-461c-4dc0-ab9e-b0d3750ac9a4,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)OC2=C(C3=C(C(=C2OC4=CC=CC=C4)N)C(=O)C5=CC=CC=C5C3=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/80839,PubChem,Nc1c(Oc2ccccc2)c(Oc2ccccc2)c(N)c2c1C(=O)c1ccccc1C2=O,Train "EU_REACH: 4-[(2,5-dichlorophenyl)azo]-3-hydroxy-N-(2-methoxyphenyl)naphthalene-2-carboxamide",,6410-38-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21751/7/4/2/?documentUUID=2ee44ede-7d8b-40aa-8170-5c2ef3ad7a4e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC=CC=C1NC(=O)C2=CC3=CC=CC=C3C(=C2O)N=NC4=C(C=CC(=C4)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/22920,PubChem,COc1ccccc1NC(=O)c1cc2ccccc2c(N=Nc2cc(Cl)ccc2Cl)c1O,Train "JP_CHRIP: Ethanol","JP_CHRIP: Ethanol in alcoholic beverages Ethyl alcohol",64-17-5,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-2007e.html,"JP_CHRIP: It was classified as ""Not classified"" because it is assessed in SIDS (2005) that in a 4-hour exposure test with rabbits (OECD TG 404), the average scores at 1 and 24 hours after application were 1.0 for erythema, the average scores at the other time points were all 0.0 for erythema and edema, and it was not irritating.",Provided,JP_CHRIP,1,CCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.930E,J-GLOBAL,CCO,Train "AU_HCIS: Formic acid … % JP_CHRIP: Formic acid KR_NCIS: Formic acid NZ_CCID: Formic acid with more than 85% acid by mass","AU_HCIS: Methanoic acid Hydrogen carboxylic acid Aminic acid Acidium formicum Myrmicyl JP_CHRIP: Aminic acid Formylic acid Hydrogen carboxylic acid Methanoic acid NZ_CCID: Aminic acid, Formic acid, Formylic acid, Hydrogen carboxylic acid, Methanoic acid, Myrmicyl",64-18-6,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=2182 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2029e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/578E110A-4904-4695-9750-4B088906FE43","JP_CHRIP: There is a report that corrosivity and strong irritation were observed in a skin irritation test with rabbits (DFGOT vol. 19 (2003), IUCLID (2000)), and there are many descriptions that it was corrosive to human skin (SIDS (2011), NTP TR19 (1992), OEL Documentations (Japan Society For Occupational Health (JSOH), 1978), Environmental Risk Assessment for Chemical Substances Vol.6, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2008)), therefore, it was classified in Category 1. Besides, this substance has pH=2.2 (at 10 g/L, 20 deg C) (IUCLID (2000)), and it was classified in ""C: R35"" in the EU DSD classification, and in ""H314 Skin Corr. 1A"" in the EU CLP classification. NZ_CCID: Skin Irritation R-PHRASE: R 35 Causes severe burns. [iuclid 2000] REMARK: UN class 8 PG II Eye Irritation R-PHRASE: R 35 Causes severe burns. [iuclid 2000]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID",4,OC=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.402H,J-GLOBAL,O=CO,Train "JP_CHRIP: Acetic acid NZ_CCID: Acetic acid >80% aqueous solution US_HSDB: ACETIC ACID","JP_CHRIP: acetic acid, of a concentration of more than 10 per cent, by weight, of acetic acid Ethanoic acid Ethylic acid Glacial acetic acid Methanecarboxylic acid NZ_CCID: Ethanoic acid, Ethylic acid, Glacial acetic acid, Methane carboxylic acid, Vinegar acid",64-19-7,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-2026e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/584EE2CE-4D24-4124-80E2-C933677851B6 US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/40","JP_CHRIP: In tests with rabbits and guinea pigs (PATTY (5th, 2001), ACGIH (2004)), the degree of irritation depended on the application concentrations and exposure periods. Concentrations from 50 - 80% produced severe burns and eschar formation. The substance is classified into C; R35 in EU classification. Based on these data, the substance was classified into Category 1. In addition, the pH is 2.4 (1.0M) (Merck (14th, 2006)). NZ_CCID: Skin Irritation UN CLASS: 8 PG II Eye Irritation R-PHRASE: R 35 Causes severe burns. [IUCLID 2000]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,CC(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.355H,J-GLOBAL,CC(=O)O,Train "EU_REACH: 1,1'-(4-methyl-1,3-phenylene)bis-1H-pyrrole-2,5-dione",,6422-83-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24680/7/4/2/?documentUUID=3b7daa9c-d65e-4a35-beda-248660b53e28,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)N2C(=O)C=CC2=O)N3C(=O)C=CC3=O,https://pubchem.ncbi.nlm.nih.gov/compound/80893,PubChem,Cc1ccc(N2C(=O)C=CC2=O)cc1N1C(=O)C=CC1=O,Train "EU_REACH: 4-{2-[2-(morpholin-4-yl)ethoxy]ethyl}morpholine",,6425-39-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13298/7/4/2/?documentUUID=803df8c4-eddb-4170-83b5-f0ff3a63888b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1COCCN1CCOCCN2CCOCC2,https://pubchem.ncbi.nlm.nih.gov/compound/80900,PubChem,C1CN(CCOCCN2CCOCC2)CCO1,Train "EU_REACH: N-(2-hydroxyethyl)-N-[2-[(1-oxooctyl)amino]ethyl]-β-alanine",,64265-45-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24845/7/4/2/?documentUUID=c87fa00f-e8b9-4df7-a23a-3e29b6594b70,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCC(=O)NCCN(CCC(=O)O)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/116569,PubChem,CCCCCCCC(=O)NCCN(CCO)CCC(=O)O,Train "EU_REACH: 3-(decylalkyl-(branched)oxy)-propiononitrile",,64354-92-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5608/7/4/2/?documentUUID=8fd65cbb-9be6-4908-adcf-7e8be2f5ae6a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCCCOCCC#N,https://pubchem.ncbi.nlm.nih.gov/compound/110608,PubChem,CC(C)CCCCCCCOCCC#N,Train "AU_HCIS: 3(2H)-Isothiazolone, 4,5-dichloro-2-octyl- JP_CHRIP: 4,5-dichloro-2-octyl-2H-isothiazol-3-one KR_NCIS: 4,5-Dichloro-2-N-octyl-4-isothiazolin-3-one NZ_CCID: 3(2H)-Isothiazolone, 4,5-dichloro-2-octyl- US_HSDB: 4,5-Dichloro-2-octyl-3-isothiazolone","JP_CHRIP: 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one NZ_CCID: 4,5-Dichloro-2-octyl-2H-isothiazol-3-one, 4,5-Dichloro-2-n-octyl-3(2H)-isothiazolone, 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one, 4,5-Dichloro-2-octyl-3(2H)-isothiazolone, DCOIT",64359-81-5,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6597 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0014e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F0A9E98B-3BCA-461E-9C19-DD0A189DDDF1 US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8454","JP_CHRIP: [Rationale for the Classification] It was classified in Category 1 from (1) - (4). [Evidence Data] (1) It is reported that in a human repeated insult patch test (HRIPT) in 34 persons, barely perceptible to moderate irritation reactions were observed in 16 during the induction phase with a 0.025% solution of this substance (ECHA RAC Opinion (2018)). (2) In a skin irritation test with rabbits (n = 3) (OECD TG 404, 4-hour application, 14-day observation), all the animals showed slight to severe erythema/edema throughout 14 days, and effects were irreversible. Destruction of all layers of the skin was estimated after 4-hour application of this substance (erythema/eschar score: 3.3/2/1.7, edema score: 2.7/2/2) (ECHA RAC Opinion (2018), AICIS (formerly, NICNAS IMAP) (2018)). (3) In a skin irritation test with a rabbit (n = 1) (OECD TG 404, 4-hour application, 14-day observation), the mean score at 24/48/72 hours was 4.0 for erythema and 3.3 for edema. Skin irritation indicative of corrosivity (concave eschar) was seen within 48 hours, and corrosive findings (ulcer /erosion) were observed after 14 days. Skin reactions were considered as corrosive (ECHA RAC Opinion (2018), AICIS (formerly, NICNAS IMAP) (2018)). (4) In a skin irritation test with rabbits (n = 6) (OECD TG 404, 4-hour application, 14-day observation), moderate to severe erythema/edema was seen after 1 hour. The mean score at 24/48/72 hours was 4.0 for erythema and 3.9 for edema. At 14 days, there was no edema, but slight to severe erythema, eschar, areas without hair growth, and whitened areas, and scar formation was observed in 5 of 6 animals. Skin reactions were considered as corrosive (ECHA RAC Opinion (2018), AICIS (formerly, NICNAS IMAP) (2018)). NZ_CCID: Skin Irritation SPECIES: Rabbit RESULT: Corrosive REFERENCE SOURCE: Rohm and Haas product MSDS for Sea nine - 211. REMARK: Sea nine 211 comprises >30% 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one, >68% o-xylene and 2% impurities . Eye Irritation SPECIES: RESULT: RH-287 is considered corrosive to the skin and eyes. REFERENCE SOURCE: EPA Federal Register http://pmep.cce.cornell.edu/profiles/miscpesticides/alphaalkyl-metaldehyde/cas64359-81-5/cas64359-81-5_pet_998.html REMARK: RH-287 = 4,5-dichloro-2-n-octyl-3(2H)-isothiazolone, CASRN 64359-81- 5.",Provided,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,CCCCCCCCn1sc(Cl)c(Cl)c1=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J286.903I,J-GLOBAL,CCCCCCCCn1sc(Cl)c(Cl)c1=O,Train "EU_REACH: Resin acids and Rosin acids, hydrogenated, esters with pentaerythritol",,64365-17-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11459/7/4/2/?documentUUID=63825caf-cad2-40a7-998b-1a5d35124c70,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C1=CC2=CC[C@@H]3[C@@]([C@H]2CC1)(CCC[C@@]3(C)C(=O)OCC(CO)(CO)CO)C,https://pubchem.ncbi.nlm.nih.gov/compound/72941941,PubChem,CC(C)C1=CC2=CC[C@@H]3[C@](C)(CCC[C@@]3(C)C(=O)OCC(CO)(CO)CO)[C@H]2CC1,Train "EU_REACH: phthalaldehyde JP_CHRIP: Phthalaldehyde NZ_CCID: Phthaldialdehyde US_HSDB: o-Phthalaldehyde","NZ_CCID: o-phthalaldehyde",643-79-8,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27723/7/4/2/?documentUUID=58a3c705-4301-4b4c-8a2e-22a9e8b28db8 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-0012e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F326FCEF-1624-4060-9893-13E826AA995E US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8456","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: [Rationale for the Classification] Based on (1), it was classified in Category 1. [Evidence Data] (1) In a skin irritation test (4 hour-semi-occlusive application) with rabbits in compliance with OECD TG 404, the mean scores for erythema and edema at 24/48/72 hours were 1.8 and 2.9, respectively. Since eschar and scars were notable 14 days post application, it was judged to be corrosive (REACH registration dossier (Access on July 2019)). NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",Provided,"EU_REACH, JP_CHRIP, NZ_CCID, US_HSDB",4,O=Cc1ccccc1C=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J45.641A,J-GLOBAL,O=Cc1ccccc1C=O,Train "JP_CHRIP: Phenyldichlorophosphine KR_NCIS: Dichloro(phenyl)phosphine NZ_CCID: Dichlorophenylphosphine","JP_CHRIP: Benzenephosphonous dichloride dichlorophenylphosphine",644-97-3,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0107e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/225BB3F0-ED51-4763-9E3D-07BEB4468DCE","JP_CHRIP: It was classified in Category 1 because it is described that it is a high irritant to the skin, eye, and mucous membranes and is highly capable of causing deaths or permanent injury due to exposure of normal use in humans (HSDB (2003)), and it is also described that it is corrosive to the skin and tissue (HSDB (2003)). NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,ClP(Cl)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J34.568G,J-GLOBAL,ClP(Cl)c1ccccc1,Train "NZ_CCID: 3-Phenylpropionyl chloride",,645-45-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B494127C-6202-4C08-9F2F-BEDAA2285D31,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)CCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/64801,PubChem,O=C(Cl)CCc1ccccc1,Train "NZ_CCID: 4-Methyl pentanoic acid","NZ_CCID: 4-methylvaleric acid",646-07-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E102356D-9F8A-4C2B-B45F-9944A448324C,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)CCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/12587,PubChem,CC(C)CCC(=O)O,Train "EU_REACH: N-(dodecylphenyl)naphthalen-1-amine",,64654-05-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29609/7/4/2/?documentUUID=7a5e635c-a4cd-4272-acfc-94d1aad845c4,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCC1=CC=CC=C1NC2=CC=CC3=CC=CC=C32,https://pubchem.ncbi.nlm.nih.gov/compound/116650,PubChem,CCCCCCCCCCCCc1ccccc1Nc1cccc2ccccc12,Train "AU_HCIS: diethyl sulphate JP_CHRIP: Diethyl sulfate KR_NCIS: Diethyl sulfate NZ_CCID: Diethyl sulphate","AU_HCIS: diethyl sulfate JP_CHRIP: Diethyl sulfate DES diethyl sulphate Sulfuric acid diethyl ester Sulfuric acid, diethyl ester KR_NCIS: Sulfuric acid, diethyl ester; Diethylsulfate NZ_CCID: Diethylsulfate, Ethyl sulfate, Sulfuric acid diethyl ester, Sulfuric acid, diethyl ester",64-67-5,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1341 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0992e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3C7A3911-6A76-4272-BD6A-100FD48BEE17","JP_CHRIP: From description that the necrosis arose by application on the skin of the rabbit (CERI Hazard Data (1996) and DFGOT (vol.20, 2003)), it was judged that there was caustic and it was set as Category 1A-1C. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID",4,CCOS(=O)(=O)OCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.811H,J-GLOBAL,CCOS(=O)(=O)OCC,Train "JP_CHRIP: iodoacetic acid NZ_CCID: Iodoacetic acid US_HSDB: Iodoacetic acid",,64-69-7,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0069e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/124018A4-303E-4677-ADD2-7DFAA28A8A39 US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/4008","JP_CHRIP: Two human cases of severe and bullous contact dermatitis have been reported (HSDB (2003)), and it is rated R35 in EU classification (EU Annex I (assessed on July, 2008)) and its pH = 1.4 (20degC, 50 g/L) (GESTIS (accessed July 2008)). Thus, the substance was classified into Category 1. NZ_CCID: Skin Irritation R PHRASE: R 35 [Company Data] Eye Irritation R PHRASE: R 35 [Company Data]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,OC(=O)CI,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.405B,J-GLOBAL,O=C(O)CI,Train "EU_REACH: 2,2'-[(3,3'-dimethoxybiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis(3-oxo-N-phenylbutanamide)",,6505-28-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16885/7/4/2/?documentUUID=6b3d00ed-6ab5-4100-b222-c2ce91c018b1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC=CC=C1)N=NC2=C(C=C(C=C2)C3=CC(=C(C=C3)N=NC(C(=O)C)C(=O)NC4=CC=CC=C4)OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/110869,PubChem,COc1cc(-c2ccc(N=NC(C(C)=O)C(=O)Nc3ccccc3)c(OC)c2)ccc1N=NC(C(C)=O)C(=O)Nc1ccccc1,Train "EU_REACH: 1,4:3,6-dianhydro-D-glucitol",,652-67-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5661/7/4/2/?documentUUID=a578aafc-d6e2-4d0c-a70a-934b4bbf598c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1[C@H]([C@@H]2[C@H](O1)[C@H](CO2)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/12597,PubChem,O[C@@H]1CO[C@H]2[C@@H]1OC[C@@H]2O,Train "EU_REACH: 3-hydroxy-N-(2-methylphenyl)-4-[(2,4,5-trichlorophenyl)diazenyl]-2-naphthamide",,6535-46-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14453/7/4/2/?documentUUID=26b187c5-65c1-401b-a17e-cdd69a6c1518,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=CC=C1NC(=O)C2=CC3=CC=CC=C3C(=C2O)N=NC4=CC(=C(C=C4Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/23034,PubChem,Cc1ccccc1NC(=O)c1cc2ccccc2c(N=Nc2cc(Cl)c(Cl)cc2Cl)c1O,Train "EU_REACH: (1r,1's,4r,4'r)-4'-propyl-[1,1'-bi(cyclohexane)]-4-carboxylic acid",,65355-32-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26387/7/4/2/?documentUUID=658e847d-2583-4d44-ba1c-e489d852a25c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1CCC(CC1)C2CCC(CC2)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/793726,PubChem,CCCC1CCC(C2CCC(C(=O)O)CC2)CC1,Train "KR_NCIS: 2-Amino-5-hydroxy-1,7-naphthalenedisulphonic acid",,6535-70-2,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C1=CC(=C(C2=C1C(=CC(=C2)S(=O)(=O)O)O)S(=O)(=O)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/81024,PubChem,Nc1ccc2c(O)cc(S(=O)(=O)O)cc2c1S(=O)(=O)O,Train "EU_REACH: 2-methyl-4-(2,6,6-trimethylcyclohex-2-en-1-yl)butanal",,65405-84-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10563/7/4/2/?documentUUID=d0af65ba-5533-4852-87ac-feb2c803c3eb,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CCC=O)C1C(=CCCC1(C)C)C,https://cactus.nci.nih.gov/chemical/structure/65405-84-7/smiles,CACTUS,CC1=CCCC(C)(C)C1C(C)CCC=O,Train "EU_REACH: 2,2,5-trimethyl-5-pentylcyclopentan-1-one",,65443-14-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17440/7/4/2/?documentUUID=a84c225c-f484-430c-b906-6b778ec057af,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCC1(CCC(C1=O)(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/103402,PubChem,CCCCCC1(C)CCC(C)(C)C1=O,Train "NZ_CCID: 2,4,6-Triisopropylbenzenesulphonyl chloride",,6553-96-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/035578E0-1BC7-4B67-9513-CD7E4AE0FACA,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)C1=CC(=C(C(=C1)C(C)C)S(=O)(=O)Cl)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/81042,PubChem,CC(C)c1cc(C(C)C)c(S(=O)(=O)Cl)c(C(C)C)c1,Train "EU_REACH: 3,4-dichlorobenzonitrile",,6574-99-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11998/7/4/2/?documentUUID=7a6880ae-422e-4d9a-a135-e6d271501960,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C=C1C#N)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/81051,PubChem,N#Cc1ccc(Cl)c(Cl)c1,Train "EU_REACH: Dimethoxy-methyl-[3-(oxiran-2-ylmethoxy)propyl]silane",,65799-47-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25241/7/4/2/?documentUUID=119db97d-d3ac-47cb-8ea8-533f47c3dfa6,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CO[Si](C)(CCCOCC1CO1)OC,https://pubchem.ncbi.nlm.nih.gov/compound/2759249,PubChem,CO[Si](C)(CCCOCC1CO1)OC,Train "EU_REACH: 2-ethyl-2-(((3,5,5-trimethylhexanoyl)oxy)methyl)propane-1,3-diyl bis(3,5,5-trimethylhexanoate)",,65870-94-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5388/7/4/2/?documentUUID=7c3a05d6-9c84-408f-bf81-cabb24589733,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(COC(=O)CC(C)CC(C)(C)C)(COC(=O)CC(C)CC(C)(C)C)COC(=O)CC(C)CC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/54263204,PubChem,CCC(COC(=O)CC(C)CC(C)(C)C)(COC(=O)CC(C)CC(C)(C)C)COC(=O)CC(C)CC(C)(C)C,Train "EU_REACH: butyl 2-cyanoprop-2-enoate",,6606-65-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11564/7/4/2/?documentUUID=e025a324-6e92-4598-8805-833941225731,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOC(=O)C(=C)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/23087,PubChem,C=C(C#N)C(=O)OCCCC,Train "EU_REACH: 1,4,7-Trioxacyclotridecane-8,13-dione",,6607-34-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6710/7/4/2/?documentUUID=7d2d6a1d-0dc0-4826-af2f-e07cef4b5254,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CCC(=O)OCCOCCOC(=O)C1,https://pubchem.ncbi.nlm.nih.gov/compound/81082,PubChem,O=C1CCCCC(=O)OCCOCCO1,Train "EU_REACH: 455-890-7",,6607-41-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15687/7/4/2/?documentUUID=3f580708-c9ff-4d52-99ef-a8a440fe22f0,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3C2(C4=CC=C(C=C4)O)C5=CC=C(C=C5)O,https://pubchem.ncbi.nlm.nih.gov/compound/2832097,PubChem,O=C1c2ccccc2C(c2ccc(O)cc2)(c2ccc(O)cc2)N1c1ccccc1,Train "EU_REACH: 3-ethyl-5,5-dimethyloxolan-2-one",,66094-79-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33920/7/4/2/?documentUUID=e85aff9b-4c5d-4214-9d6b-59f3af539f2b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1CC(OC1=O)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/12393270,PubChem,CCC1CC(C)(C)OC1=O,Train "EU_REACH: 2-ethoxybenzonitrile",,6609-57-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30034/7/4/2/?documentUUID=17ee1751-4ecc-437f-9867-828f94051d63,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC1=CC=CC=C1C#N,https://pubchem.ncbi.nlm.nih.gov/compound/576922,PubChem,CCOc1ccccc1C#N,Train "EU_REACH: 1-amino-3-methylthiourea",,6610-29-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10986/7/4/2/?documentUUID=00cce467-247b-4fc8-8677-477e30237dcc,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CNC(=S)NN,https://pubchem.ncbi.nlm.nih.gov/compound/2723853,PubChem,CNC(=S)NN,Train "EU_REACH: N2-cyclopropyl-1,3,5-triazine-2,4,6-triamine",,66215-27-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33022/7/4/2/?documentUUID=727e271e-befd-4754-9bbf-19ae5f5ba261,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC1NC2=NC(=NC(=N2)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/47866,PubChem,Nc1nc(N)nc(NC2CC2)n1,Train "EU_REACH: N-[2-[(2-chloro-4,6-dinitrophenyl)azo]-5-(diethylamino)phenyl]acetamide",,66557-45-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20015/7/4/2/?documentUUID=013168fb-5a20-47b9-9d79-5d8515924f69,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN(CC)C1=CC(=C(C=C1)N=NC2=C(C=C(C=C2Cl)[N+](=O)[O-])[N+](=O)[O-])NC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/3017688,PubChem,CCN(CC)c1ccc(N=Nc2c(Cl)cc([N+](=O)[O-])cc2[N+](=O)[O-])c(NC(C)=O)c1,Train "EU_REACH: isopropyl 2-methylbutyrate",,66576-71-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23871/7/4/2/?documentUUID=3589c168-755f-4b1a-977b-e1daa2b2722b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C)C(=O)OC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/522214,PubChem,CCC(C)C(=O)OC(C)C,Train "NZ_CCID: 1,8-Diazabicyclo[5.4.0]undec-7-ene",,6674-22-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2FD4F486-BD79-4972-870D-99C7ED29853F,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CCC2=NCCCN2CC1,https://pubchem.ncbi.nlm.nih.gov/compound/81184,PubChem,C1CCC2=NCCCN2CC1,Train "EU_REACH: 4-methyl-2,6-bis[(4-methylphenyl)amino]-5-{2-[2-(trifluoromethyl)phenyl]diazen-1-yl}pyridine-3-carbonitrile",,669005-94-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6226/7/4/2/?documentUUID=ee862930-5008-46f2-a1c9-edf15ae4d9ec,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)NC2=C(C(=C(C(=N2)NC3=CC=C(C=C3)C)C#N)C)N=NC4=CC=CC=C4C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/11605744,PubChem,Cc1ccc(Nc2nc(Nc3ccc(C)cc3)c(N=Nc3ccccc3C(F)(F)F)c(C)c2C#N)cc1,Train "EU_REACH: 5-amino-6-methyl-2,3-dihydro-1H-1,3-benzodiazol-2-one",,67014-36-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10453/7/4/2/?documentUUID=d41af473-2546-49ad-a0d1-9506ddd64e80,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC2=C(C=C1N)NC(=O)N2,https://pubchem.ncbi.nlm.nih.gov/compound/352271,PubChem,Cc1cc2[nH]c(=O)[nH]c2cc1N,Train "EU_REACH: 2-chlorophenyl cyclopentyl ketone",,6740-85-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24360/7/4/2/?documentUUID=f7aa4481-c327-456b-9f65-a3d1681d0899,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CCC(C1)C(=O)C2=CC=CC=C2Cl,https://pubchem.ncbi.nlm.nih.gov/compound/81223,PubChem,O=C(c1ccccc1Cl)C1CCCC1,Train "EU_REACH: methyl 5-amino-4-cyano-3-(2-methoxy-2-oxoethyl)thiophene-2-carboxylate",,674773-12-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7465/7/4/2/?documentUUID=afbfc8f6-0c64-4045-9bb3-cd89b6e61a5e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)CC1=C(SC(=C1C#N)N)C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/4962422,PubChem,COC(=O)Cc1c(C(=O)OC)sc(N)c1C#N,Train "EU_REACH: methyl 5-[bis(2-methoxy-2-oxoethyl)amino]-4-cyano-3-(2-methoxy-2-oxoethyl)thiophene-2-carboxylate",,674773-13-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1349/7/4/2/?documentUUID=c5787410-abb6-4182-b3b3-efd47bb13285,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)CC1=C(SC(=C1C#N)N(CC(=O)OC)CC(=O)OC)C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/11516837,PubChem,COC(=O)Cc1c(C(=O)OC)sc(N(CC(=O)OC)CC(=O)OC)c1C#N,Train "NZ_CCID: Fenpropimorph",,67564-91-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/101A2BA3-D345-4ED0-B7A8-80A80C351416,"NZ_CCID: Skin Irritation SPECIES: Rabbit RESULT: A dose of 0.5 ml of fenpropimorph (purity, > 91%) was applied to the intact dorsal skin of four white Vienna rabbits for 3 min or 4 h, and animals were observed up to day 8 after treatment. Fenpropimorph caused slight to moderate erythema and oedema after either application. The reactions intensified, and two of four rabbits had necrosis eight days after the 4-h exposure. In the 3-min test, animals had necrotic-like skin changes and/or scaling. REFERENCE SOURCE: 881. Fenpropimorph (Pesticide residues in food: 1994 evaluations Part II Toxicology) Joint Meeting on Pesticide Residues. [INCHEM] Eye Irritation SPECIES: Rabbit RESULT: The irritancy of fenpropimorph to the eye was examined in three white Vienna rabbits in a study in which 0.1 ml of fenpropimorph (purity, > 91%) was instilled into the conjunctival sac of the right eye. Observations were made up to day 8 after instillation. Slight to distinct conjunctival redness was observed in all rabbits. Fenpropimorph was considered to be irritating to the rabbit eye, since slight irritation was still seen at the end of the study. REFERENCE SOURCE: 881. Fenpropimorph (Pesticide residues in food: 1994 evaluations Part II Toxicology) Joint Meeting on Pesticide Residues. [INCHEM]",,NZ_CCID,1,C[C@@H]1CN(C[C@@H](O1)C)CC(C)CC2=CC=C(C=C2)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/93365,PubChem,CC(Cc1ccc(C(C)(C)C)cc1)CN1C[C@@H](C)O[C@@H](C)C1,Train "EU_REACH: 2-(N-methyl-1,1,2,2,3,3,4,4,4-nonafluorobutanesulfonamido)ethyl prop-2-enoate",,67584-55-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11481/7/4/2/?documentUUID=1441e1f1-2cc3-40bd-b329-312fc9cd77e1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(CCOC(=O)C=C)S(=O)(=O)C(C(C(C(F)(F)F)(F)F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/105447,PubChem,C=CC(=O)OCCN(C)S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train "EU_REACH: (3Z)-hex-3-en-1-yl methyl carbonate",,67633-96-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19877/7/4/2/?documentUUID=98250679-1eb5-4a29-b57a-fb23e8e7db69,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC/C=C\CCOC(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/5365699,PubChem,CC/C=C\CCOC(=O)OC,Train "EU_REACH: 2-{[(2R)-3,5-dimethylhex-3-en-2-yl]oxy}-2-methylpropyl cyclopropanecarboxylate; 2-{[(2S)-3,5-dimethylhex-3-en-2-yl]oxy}-2-methylpropyl cyclopropanecarboxylate",,676532-44-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32813/7/4/2/?documentUUID=3f50d90a-da73-4ac4-a6ec-a17c86f395ca,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C=C(C)C(C)OC(C)(C)COC(=O)C1CC1,https://pubchem.ncbi.nlm.nih.gov/compound/66769843,PubChem,CC(=CC(C)C)C(C)OC(C)(C)COC(=O)C1CC1,Train "JP_CHRIP: Dimethyl sulfoxide","JP_CHRIP: DMSO Methyl sulphoxide",67-68-5,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-0023e.html,"JP_CHRIP: [Rationale for the Classification] Based on (1), it was classified as ""Not classified."" [Evidence Data] (1) In a skin irritation test with rabbits according to OECD TG 404, a very slight or well-defined erythema was observed, but all these disappeared within 72 hours (SIDS (2008), GESTIS (Access on September 2019), REACH registration dossier (Access on November 2019)). [Reference Data, etc.] (2) Skin irritation can develop at the site where this substance is applied topically (HSDB (Access on September 2019)).",Provided,JP_CHRIP,1,CS(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.933J,J-GLOBAL,CS(C)=O,Train "JP_CHRIP: methylphosphonic dichloride","JP_CHRIP: Methylphosphonic dichloride Methylphosphonic dichloride; Methylphosphonic dichloride",676-97-1,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-1090e.html,"JP_CHRIP: In Priority 2, the this product was very corrosiveness, and since there was description that the contact to the human skin causes a critical burned (SITTIG (4th, 2002)), it was set as Category 1A-1C. [view] It is more desirable to be set as Category 1A from a viewpoint of safety, when further categorizing needs to be performed.",,JP_CHRIP,1,CP(=O)(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J50.316I,J-GLOBAL,CP(=O)(Cl)Cl,Train "EU_REACH: ethyl 3,5,5-trimethylhexanoate",,67707-75-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19592/7/4/2/?documentUUID=7f762d62-bf8d-4d4a-832b-e17da61a9985,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)CC(C)CC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/3017783,PubChem,CCOC(=O)CC(C)CC(C)(C)C,Train "JP_CHRIP: Alcohol (C=10-16)","JP_CHRIP: (C10-C16) Alkyl alcohol; SDA 15-060-00 Alcohols, C10-16",67762-41-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-0084e.html,"JP_CHRIP: It was classified as ""Not classified"" because it is reported that the average scores after 72 hours for erythema and edema were 0.3 and 0.2 in a skin corrosion test with rabbits according to OECD TG 404, and the symptoms disappeared within seven days (SIDS (2007)).",Provided,JP_CHRIP,1,CCCCCCCCCCCCCCO,https://pubchem.ncbi.nlm.nih.gov/compound/8209,PubChem,CCCCCCCCCCCCCCO,Train "AU_HCIS: Isooctadecanamide, N-[3-(dimethylamino)propyl]-",,67799-04-6,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6767,,,AU_HCIS,1,CC(C)CCCCCCCCCCCCCCC(=O)NCCCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/105621,PubChem,CC(C)CCCCCCCCCCCCCCC(=O)NCCCN(C)C,Train "EU_REACH: 2-tert-butylcyclohexyl ethyl carbonate",,67801-64-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20369/7/4/2/?documentUUID=59f4d925-5d6a-4663-b5d2-1a79b2c75066,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)OC1CCCCC1C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/105664,PubChem,CCOC(=O)OC1CCCCC1C(C)(C)C,Train "EU_REACH: hexadecyl 3,5-di-tert-butyl-4-hydroxybenzoate",,67845-93-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5453/7/4/2/?documentUUID=d1b62fef-3a80-4920-81fc-ef26fd0aba1a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCOC(=O)C1=CC(=C(C(=C1)C(C)(C)C)O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/94623,PubChem,CCCCCCCCCCCCCCCCOC(=O)c1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1,Train "EU_REACH: diisotridecyl phenyl phosphite",,67874-37-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23926/7/4/2/?documentUUID=b9601a9d-8ca8-42c4-b37d-d43e0db45f11,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCCCCCCOP(OCCCCCCCCCCC(C)C)OC1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/105872,PubChem,CC(C)CCCCCCCCCCOP(OCCCCCCCCCCC(C)C)Oc1ccccc1,Train "EU_REACH: 3,3'-[[4-[(2,6-dichloro-4-nitrophenyl)azo]phenyl]imino]bispropiononitrile",,67923-43-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21965/7/4/2/?documentUUID=4aa0185c-b47d-4145-9fbd-0d4ed220d92b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1N=NC2=C(C=C(C=C2Cl)[N+](=O)[O-])Cl)N(CCC#N)CCC#N,https://pubchem.ncbi.nlm.nih.gov/compound/106138,PubChem,N#CCCN(CCC#N)c1ccc(N=Nc2c(Cl)cc([N+](=O)[O-])cc2Cl)cc1,Train "EU_REACH: (3-chloro-2-fluorophenyl)(2,4-dimethoxyphenyl)methanone",,680610-70-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18430/7/4/2/?documentUUID=d39ccf2d-8349-4240-8fa5-5f4545f31677,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC(=C(C=C1)C(=O)C2=C(C(=CC=C2)Cl)F)OC,https://pubchem.ncbi.nlm.nih.gov/compound/64713965,PubChem,COc1ccc(C(=O)c2cccc(Cl)c2F)c(OC)c1,Train "AU_HCIS: Acetic acid, mercapto- JP_CHRIP: Mercaptoacetic acid KR_NCIS: Mercaptoacetic acid NZ_CCID: Thioglycolic acid US_HSDB: MERCAPTOACETIC ACID","AU_HCIS: thioglycolic acid Mercaptoacetic acid Thiovanic acid 2-Mercaptoacetate 2-Sulfanylacetic acid JP_CHRIP: 2-Mercaptoethanoic acid Ethanethiol-2-acid-1 mercaptoacetic acid Thioglycolic acid KR_NCIS: thioglycolic acid NZ_CCID: 2-Mercaptoacetate, 2-Thioglycolic acid, Acetic acid, mercapto-, Glycolic acid, 2-thio-, Mercaptoacetic acid, Thioglycolate, Thioglycollic acid",68-11-1,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=54 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2106e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AE50DEFC-48BD-4B2A-88BB-9F41F47E1439 US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/2702","JP_CHRIP: Since necrosis was observed within 5 minutes after application of the undiluted liquid of this substance to the skin of rabbits, this substance was judged to be corrosive (SIDS (2010)). In humans, there are reports that by exposure to this substance at a high concentration, it caused a second-degree burn on the skin (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), and that ulcers and a permanent scar were observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). From the above results, it was classified in Category 1. Besides, this substance was classified as ""R34"" in the EU DSD classification, and as ""Skin Corr. 1B H314"" in the EU CLP classification. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,OC(=O)CS,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.856I,J-GLOBAL,O=C(O)CS,Train "EU_REACH: Resin acids and rosin acids, Me esters",,68186-14-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10758/7/4/2/?documentUUID=923d372e-ac82-4be3-a5fa-64c27c79b78e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C1=CC2=CCC3[C@@]([C@@H]2CC1)(CCC[C@]3(C)C(=O)OC)C,https://pubchem.ncbi.nlm.nih.gov/compound/18634581,PubChem,COC(=O)[C@@]1(C)CCC[C@@]2(C)C1CC=C1C=C(C(C)C)CC[C@H]12,Train "EU_REACH: tetrapropyl silicate",,682-01-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14206/7/4/2/?documentUUID=1d275aa8-1c8c-488f-a247-02da1d410fc5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCO[Si](OCCC)(OCCC)OCCC,https://pubchem.ncbi.nlm.nih.gov/compound/69627,PubChem,CCCO[Si](OCCC)(OCCC)OCCC,Train "EU_REACH: 2,2-bis[(prop-2-en-1-yloxy)methyl]butan-1-ol",,682-09-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1894/7/4/2/?documentUUID=00fd4203-7263-4323-aa29-bf5ecc24e1a7,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(CO)(COCC=C)COCC=C,https://pubchem.ncbi.nlm.nih.gov/compound/61196,PubChem,C=CCOCC(CC)(CO)COCC=C,Train "EU_REACH: N-(5-chloro-2-methylphenyl)-3-hydroxy-4-{[2-methoxy-5-(phenylcarbamoyl)phenyl]diazenyl}-2-naphthamide",,68227-78-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11197/7/4/2/?documentUUID=cbdd0d1c-9c55-4445-9c87-4517d48a9540,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)Cl)NC(=O)C2=CC3=CC=CC=C3C(=C2O)N=NC4=C(C=CC(=C4)C(=O)NC5=CC=CC=C5)OC,https://pubchem.ncbi.nlm.nih.gov/compound/109852,PubChem,COc1ccc(C(=O)Nc2ccccc2)cc1N=Nc1c(O)c(C(=O)Nc2cc(Cl)ccc2C)cc2ccccc12,Train "EU_REACH: 5(or 6)-methyl-7(or 8)-(1-methylethyl)bicyclo[2.2.2]oct-5-ene-2-carbaldehyde",,68259-31-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18521/7/4/2/?documentUUID=0c0919c3-b2d4-4744-89fe-3b9ce144d2ec,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C2CC(C(C1)C(C2)C(C)C)C=O,https://pubchem.ncbi.nlm.nih.gov/compound/109261,PubChem,CC1=C2CC(C=O)C(C1)C(C(C)C)C2,Train "EU_REACH: 14H-benz[4,5]isoquino[2,1-a]perimidin-14-one",,6829-22-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21766/7/4/2/?documentUUID=2356744d-187e-4cf9-b4e0-bd5d1e035100,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC2=C3C(=C1)C4=NC5=CC=CC6=C5C(=CC=C6)N4C(=O)C3=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/81271,PubChem,O=c1c2cccc3cccc(c32)c2nc3cccc4cccc(c43)n12,Train "EU_REACH: 1,1,2,2,3,3,4,4,4-nonafluoro-N-methylbutane-1-sulfonamide",,68298-12-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32215/7/4/2/?documentUUID=0725645f-d96b-427e-a892-8980163cd557,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CNS(=O)(=O)C(C(C(C(F)(F)F)(F)F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/109968,PubChem,CNS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train "EU_REACH: N-[2-[(2,6-dicyano-p-tolyl)azo]-5-(diethylamino)phenyl]methanesulphonamide",,68385-96-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22379/7/4/2/?documentUUID=fafa7b1e-f5cb-46c9-b53d-2aa8df918f10,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN(CC)C1=CC(=C(C=C1)N=NC2=C(C=C(C=C2C#N)C)C#N)NS(=O)(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/110090,PubChem,CCN(CC)c1ccc(N=Nc2c(C#N)cc(C)cc2C#N)c(NS(C)(=O)=O)c1,Train "EU_REACH: (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide",,68489-09-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17595/7/4/2/?documentUUID=54a03fc6-3619-4162-a15c-31b99d0f0339,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H]1CC[C@H]([C@@H](C1)C(=O)NC2=CC=C(C=C2)OC)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/11266244,PubChem,COc1ccc(NC(=O)[C@@H]2C[C@H](C)CC[C@H]2C(C)C)cc1,Train "NZ_CCID: 2-Methoxybenzylamine",,6850-57-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/70B7B829-691E-4EF4-A470-FB478C57D81B,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,COC1=CC=CC=C1CN,https://pubchem.ncbi.nlm.nih.gov/compound/81292,PubChem,COc1ccccc1CN,Train "EU_REACH: tetramethyl 2,2'-{1,4-phenylenebis[imino(1,3-dioxobutane-2,1-diyl)diazene-2,1-diyl]}diterephthalate",,68516-73-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14162/7/4/2/?documentUUID=9cc390ad-22b8-495e-9ff8-3e2661986c83,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC=C(C=C1)NC(=O)C(C(=O)C)N=NC2=C(C=CC(=C2)C(=O)OC)C(=O)OC)N=NC3=C(C=CC(=C3)C(=O)OC)C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/109448,PubChem,COC(=O)c1ccc(C(=O)OC)c(N=NC(C(C)=O)C(=O)Nc2ccc(NC(=O)C(N=Nc3cc(C(=O)OC)ccc3C(=O)OC)C(C)=O)cc2)c1,Train "NZ_CCID: 2,2,2-Trifluoro-N-methyl-N-(trifluoroacetyl)acetamide","NZ_CCID: N-Methyl-bis(trifluoroacetamide)",685-27-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4B8ADE0B-D5D4-4F60-BF11-A1FE26C6D211,"NZ_CCID: Skin Irritation R-PHRASE: R 34. [Chemwatch] Eye Irritation R-PHRASE: R 34/ 41. [Chemwatch]",,NZ_CCID,1,CN(C(=O)C(F)(F)F)C(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/69635,PubChem,CN(C(=O)C(F)(F)F)C(=O)C(F)(F)F,Train "EU_REACH: 11-(heptylamino)undecanoic acid",,68564-88-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32718/7/4/2/?documentUUID=522164e3-89c5-44fd-8649-065dfb77ed36,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCNCCCCCCCCCCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/110593,PubChem,CCCCCCCNCCCCCCCCCCC(=O)O,Train "NZ_CCID: Diethyl bromomalonate","NZ_CCID: Propanedioic acid, bromo-, diethyl ester",685-87-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2B1A6C59-1C41-4830-8512-7A7CC7852EA6,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCOC(=O)C(C(=O)OCC)Br,https://pubchem.ncbi.nlm.nih.gov/compound/69637,PubChem,CCOC(=O)C(Br)C(=O)OCC,Train "NZ_CCID: Carboxylic acids, di-, C4-6",,68603-87-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CA37DAD2-77AD-44AD-8ACE-2A1A4F5A0192,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,OC(=O)CCCC(O)=O,https://cactus.nci.nih.gov/chemical/structure/68603-87-2/smiles,CACTUS,O=C(O)CCCC(=O)O,Train "JP_CHRIP: 4,4'-Methylenebis(2-methylcyclohexaneamine) NZ_CCID: 4,4'-Methylenebis(2-methylcyclohexylamine)","JP_CHRIP: 2,2'-dimethyl-4,4'-methylenebis(cyclohexylamine) 2,2'-dimethyl-4,4'-methylenebis(cyclohexylamine) (synonym:4,4'-methylenebis(2-methylcyclohexanamine)) 3,3'-Dimethyl-4,4'-diaminodicyclohexylmethane 3,3'-Dimethyl-4,4'-diaminodicyclohexylmethane; 3,3'-Dimethyl-4,4'-diaminodicyclohexylmethane 4,4'-Diamino-3,3'-dimethyldicyclohexylmethane 4,4'-Methylenebis(2-methylcyclohexaneamine) 4,4'-Methylenebis-(2-methylcyclohexanamine)",6864-37-5,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0552e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EBA40DD8-8A73-4B0F-8F3B-D62F42A7DEA5","JP_CHRIP: Based on the description in the report on rabbit skin irritation tests (SIDS (2005)): ""Corrosive."" Although classified into Category 1A-1C, the substance should be placed in Category 1A from the viewpoint of safety if further subclassification is needed. NZ_CCID: Skin Irritation R PHRASE: R 35 [Company Data] Eye Irritation R PHRASE: R 35 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CC1CC(CC2CCC(N)C(C)C2)CCC1N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J39.615J,J-GLOBAL,CC1CC(CC2CCC(N)C(C)C2)CCC1N,Train "EU_REACH: 8-ethyl-9-methylheptadecane; 8-methyl-7-propylhexadecane",,68649-11-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13309/7/4/2/?documentUUID=6a980ede-0b74-46ea-8e13-ffa3dcdc5b75,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCC(C)C(C)CCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/530173,PubChem,CCCCCCCCC(C)C(C)CCCCCCCC,Train "EU_REACH: 2-{[3,4-bis(prop-2-en-1-yloxy)-2,5-bis[(prop-2-en-1-yloxy)methyl]oxolan-2-yl]oxy}-3,4,5-tris(prop-2-en-1-yloxy)-6-[(prop-2-en-1-yloxy)methyl]oxane",,68784-14-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16670/7/4/2/?documentUUID=00f984a5-8664-48d8-b93f-df7540f6204a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CCOCC1(C(C(C(O1)CO)O)O)OC2C(C(C(C(O2)CO)O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/21932943,PubChem,C=CCOCC1(OC2OC(CO)C(O)C(O)C2O)OC(CO)C(O)C1O,Train "JP_CHRIP: (5-Chloro-2-methoxy-4-methylpyridin-3-yl)(2,3,4-trimethoxy-6-methylphenyl)methanone; Pyriofenone",,688046-61-9,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0085e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 72-hour observation), no skin irritation reactions were seen in any animal (erythema/eschar score: 0/0/0, edema score: 0/0/0) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018), ECHA RAC Opinion (2019), CLH Report (2018), JMPR (2019), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2015)).",Provided,JP_CHRIP,1,O=C(C1=C(C)C(Cl)=CN=C1OC)C2=C(C)C=C(OC)C(OC)=C2OC,https://www.nite.go.jp/en/chem/chrip/chrip_search/cmpInfDsp?cid=C008-196-30A&slScNm=CI_01_001&bcPtn=3,CHRIP,COc1cc(C)c(C(=O)c2c(OC)ncc(Cl)c2C)c(OC)c1OC,Train "EU_REACH: allyl (cyclohexyloxy)acetate",,68901-15-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25443/7/4/2/?documentUUID=5fd03e45-bccb-4d99-bbe2-927985fd6ad7,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CCOC(=O)COC1CCCCC1,https://pubchem.ncbi.nlm.nih.gov/compound/111727,PubChem,C=CCOC(=O)COC1CCCCC1,Train "JP_CHRIP: Tricyclo[5.2.1.0(2,6)]dec-4-enyl propionate",,68912-13-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0016e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 8) (equivalent to OECD TG 404, semi-occlusive, 4-hour application), no skin irritation was seen (erythema/eschar score: 0.67/0.67/1/1/0.67/0/0.67/1, edema score: 1/0.67/1/1/0.67/0/1/1.33) (REACH registration dossier (Accessed Aug. 2020)).",Provided,JP_CHRIP,1,CCC(=O)OC1C=CC2C3CCC(C3)C12,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J310.533D,J-GLOBAL,CCC(=O)OC1C=CC2C3CCC(C3)C12,Train "EU_REACH: methyl 2-[(4-amino-3,5-dichloro-6-fluoropyridin-2-yl)oxy]acetate",,69184-17-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13474/7/4/2/?documentUUID=d63a50aa-26e4-42ea-ba1e-3f3ca736adc7,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)COC1=NC(=C(C(=C1Cl)N)Cl)F,https://pubchem.ncbi.nlm.nih.gov/compound/5463802,PubChem,COC(=O)COc1nc(F)c(Cl)c(N)c1Cl,Train "NZ_CCID: 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane",,69304-37-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/54680F26-E1C2-45EC-AB17-4152C39EE9F1,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)[Si](C(C)C)(O[Si](C(C)C)(C(C)C)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/172404,PubChem,CC(C)[Si](Cl)(O[Si](Cl)(C(C)C)C(C)C)C(C)C,Train "AU_HCIS: 1H-Imidazole, 2-methyl- NZ_CCID: 2-Methylimidazole","AU_HCIS: 2-methylimidazole",693-98-1,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5544 NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/37D0723A-BB63-472E-8837-D7D171CC92DF","NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"AU_HCIS, NZ_CCID",2,CC1=NC=CN1,https://pubchem.ncbi.nlm.nih.gov/compound/12749,PubChem,Cc1ncc[nH]1,Train "EU_REACH: 1-chloro-2,5-dimethoxy-4-nitrobenzene",,6940-53-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1976/7/4/2/?documentUUID=2f14d586-e514-49c2-bafc-a58016022bae,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC(=C(C=C1[N+](=O)[O-])OC)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/81362,PubChem,COc1cc([N+](=O)[O-])c(OC)cc1Cl,Train "NZ_CCID: 1,2-Cyclohexanediamine",,694-83-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4217BFAB-BED3-406F-A1C5-EA4F24B0C36C,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1CCC(C(C1)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/4610,PubChem,NC1CCCCC1N,Train "EU_REACH: N-(4-amino-3-methoxy-9,10-dioxo-9,10-dihydroanthracen-1-yl)benzenesulfonamide",,69563-51-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15911/7/4/2/?documentUUID=79c092b4-8345-4742-9545-1376b092972b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=C(C2=C(C(=C1)NS(=O)(=O)C3=CC=CC=C3)C(=O)C4=CC=CC=C4C2=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/112289,PubChem,COc1cc(NS(=O)(=O)c2ccccc2)c2c(c1N)C(=O)c1ccccc1C2=O,Train "EU_REACH: N-(2-methoxy-5-methylphenyl)acetamide",,6962-44-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5717/7/4/2/?documentUUID=e5130861-e6cc-412e-95a4-577f97b05323,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)OC)NC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/81412,PubChem,COc1ccc(C)cc1NC(C)=O,Train "EU_REACH: 2-((3-(4-Hydroxyphenyl)propanoylamino)benzoic acid",,697235-49-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11048/7/4/2/?documentUUID=f2e7a539-cf63-4d0f-9960-77de0e469081,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C(=C1)C(=O)O)NC(=O)CCC2=CC=C(C=C2)O,https://pubchem.ncbi.nlm.nih.gov/compound/10334118,PubChem,O=C(CCc1ccc(O)cc1)Nc1ccccc1C(=O)O,Train "NZ_CCID: Butyldimethylsilyl trifluoromethanesulphonate, t-",,69739-34-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/24743BCA-FCE4-4CBD-81BC-1BD585C4E393,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/123564,PubChem,CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F,Train "EU_REACH: 1-bromo-3-chloro-2-methylpropane",,6974-77-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20108/7/4/2/?documentUUID=71ea0ac0-1cd9-4a72-9c07-14245a1f7b40,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CCl)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/95566,PubChem,CC(CCl)CBr,Train "EU_REACH: 2-methoxyethyl 2-methylprop-2-enoate",,6976-93-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23723/7/4/2/?documentUUID=7c0bff77-f899-49b4-98a4-92c2f06b9072,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OCCOC,https://pubchem.ncbi.nlm.nih.gov/compound/81466,PubChem,C=C(C)C(=O)OCCOC,Train "KR_NCIS: 5-Chloro-2,4,6-trifluoropyrimidine",,697-83-6,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C1(=C(N=C(N=C1F)F)F)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/69679,PubChem,Fc1nc(F)c(Cl)c(F)n1,Train "EU_REACH: xanthine",,69-89-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33594/7/4/2/?documentUUID=99d29b75-b5f2-4195-981f-c50051874dd3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=NC2=C(N1)C(=O)NC(=O)N2,https://pubchem.ncbi.nlm.nih.gov/compound/1188,PubChem,O=c1[nH]c(=O)c2[nH]cnc2[nH]1,Train "EU_REACH: 4-[(1E)-2-(2,5-dichlorophenyl)diazen-1-yl]-3-hydroxy-N-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl)naphthalene-2-carboxamide",,6992-11-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10288/7/4/2/?documentUUID=e1ed9a77-30e4-471b-84d3-da90e6a54f7f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)C=C(C(=C2N=NC3=C(C=CC(=C3)Cl)Cl)O)C(=O)NC4=CC5=C(C=C4)NC(=O)N5,https://pubchem.ncbi.nlm.nih.gov/compound/81471,PubChem,O=C(Nc1ccc2[nH]c(=O)[nH]c2c1)c1cc2ccccc2c(N=Nc2cc(Cl)ccc2Cl)c1O,Train "JP_CHRIP: 2,3,5-Trimethylhydroquinone","JP_CHRIP: 2,3,5-Trimethylbenzene-1,4-diol",700-13-0,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0108e.html,"JP_CHRIP: It was corrosive in a test by a 4-hour occlusive application to rabbits (IUCLID (2000)), and in a test by a 4-hour occlusive application of an 80% aqueous solution of this substance to rabbits, severe erythema and slight edema remained after eight days, necrosis was also recorded, and it was judged as corrosive (IUCLID (2000)). Therefore, it was classified in Category 1. Besides, it was classified in Xi: R37/38 in EU classification.",,JP_CHRIP,1,Cc1cc(O)c(C)c(C)c1O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J12.289K,J-GLOBAL,Cc1cc(O)c(C)c(C)c1O,Train "EU_REACH: (2R,5S)-2-{4'-[difluoro(3,4,5-trifluorophenoxy)methyl]-3',5'-difluoro-[1,1'-biphenyl]-4-yl}-5-propyloxane",,700863-48-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24296/7/4/2/?documentUUID=99fa2a58-f803-4f68-98a3-d02419f7cf09,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC[C@@H]1CC[C@H](OC1)C2=CC=C(C=C2)C3=CC(=C(C(=C3)F)C(OC4=CC(=C(C(=C4)F)F)F)(F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/165366977,PubChem,CCC[C@@H]1CC[C@@H](c2ccc(-c3cc(F)c(C(F)(F)Oc4cc(F)c(F)c(F)c4)c(F)c3)cc2)OC1,Train "NZ_CCID: 2-Bromoacetophenone",,70-11-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F990AE84-7D44-4CCF-822D-B5669CC18E55,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC=C(C=C1)C(=O)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/6259,PubChem,O=C(CBr)c1ccccc1,Train "EU_REACH: 2-Chloro-5-chloromethylpyridine",,70258-18-3,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11962/7/4/2/?documentUUID=1b35f78f-7df5-4f11-820e-8ec9dc90d3e8,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=NC=C1CCl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/155479,PubChem,ClCc1ccc(Cl)nc1,Train "NZ_CCID: 3-(Trifluoromethyl)-benzyl chloride",,705-29-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3ABE1E93-59AA-489D-A849-711D6835A8EA,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)C(F)(F)F)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/69716,PubChem,FC(F)(F)c1cccc(CCl)c1,Train "EU_REACH: 2,6-bis(1,1-dimethylethyl)-4-(phenylenemethylene)cyclohexa-2,5-dien-1-one",,7078-98-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7987/7/4/2/?documentUUID=7bc25222-987c-4c4f-a58c-0df3d6f130a1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1=CC(=CC2=CC=CC=C2)C=C(C1=O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/160881,PubChem,CC(C)(C)C1=CC(=Cc2ccccc2)C=C(C(C)(C)C)C1=O,Train "EU_REACH: 2-hydroxynaphthalene-1-carbaldehyde",,708-06-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16591/7/4/2/?documentUUID=4939be3a-81ee-4596-bca5-81450614e306,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)C=CC(=C2C=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/12819,PubChem,O=Cc1c(O)ccc2ccccc12,Train "EU_REACH: 2-ethylhexyl (1,1-dimethylpropylperoxy)formate",,70833-40-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11043/7/4/2/?documentUUID=c4912599-f425-481a-a13f-4f890346af16,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)OOC(C)(C)CC,https://pubchem.ncbi.nlm.nih.gov/compound/116706,PubChem,CCCCC(CC)COC(=O)OOC(C)(C)CC,Train "EU_REACH: (1S,4R,6R)-1-[(3E)-5-hydroxy-3-methylpent-3-en-1-yn-1-yl]-2,2,6-trimethylcyclohexane-1,4-diol",,70905-68-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33700/7/4/2/?documentUUID=f4490d72-a892-408a-bd6a-a25bd971de37,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H]1C[C@H](CC([C@@]1(C#C/C(=C/CO)/C)O)(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/14631277,PubChem,C/C(C#C[C@]1(O)[C@H](C)C[C@@H](O)CC1(C)C)=C\CO,Train "EU_REACH: diisotridecyl phosphonate",,70955-74-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23633/7/4/2/?documentUUID=054995e0-65c9-42f4-9cfb-ae8e6a684b77,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCCCCCCO[P+](=O)OCCCCCCCCCCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6335864,PubChem,CC(C)CCCCCCCCCCO[P+](=O)OCCCCCCCCCCC(C)C,Train "EU_REACH: 5-amino-2-chloro-N-(2,4-dimethylphenyl)benzene-1-sulfonamide",,71215-81-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26515/7/4/2/?documentUUID=487f71eb-3b9b-4db2-9d8a-f2f8de3ca88f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)NS(=O)(=O)C2=C(C=CC(=C2)N)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/117071,PubChem,Cc1ccc(NS(=O)(=O)c2cc(N)ccc2Cl)c(C)c1,Train "NZ_CCID: Methanesulphonic anhydride",,7143-01-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/14255CAB-17C7-483C-8B2E-C16777DD8F20,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CS(=O)(=O)OS(=O)(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/81560,PubChem,CS(=O)(=O)OS(C)(=O)=O,Train "NZ_CCID: 4,9-Diazadodecamethylenediamine",,71-44-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/39A622A0-F2B9-4127-A990-6B7F19BCC5FA,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C(CCNCCCN)CNCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/1103,PubChem,NCCCNCCCCNCCCN,Train "NZ_CCID: 2-Bromobenzoyl chloride",,7154-66-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AD9D1A2C-9FC4-4448-9475-53FA4571D937,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC=C(C(=C1)C(=O)Cl)Br,https://pubchem.ncbi.nlm.nih.gov/compound/23542,PubChem,O=C(Cl)c1ccccc1Br,Train "EU_REACH: isopentyl p-methoxycinnamate",,71617-10-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12224/7/4/2/?documentUUID=75fe7fe4-035b-4ad6-a247-e8fffaff4897,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCOC(=O)/C=C/C1=CC=C(C=C1)OC,https://pubchem.ncbi.nlm.nih.gov/compound/1549789,PubChem,COc1ccc(/C=C/C(=O)OCCC(C)C)cc1,Train "NZ_CCID: Ethyldicyclohexylamine","NZ_CCID: Dicyclohexylamine, N-ethyl-",7175-49-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/394CE693-DE79-437B-8330-F3244EFEA2A6,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCN(C1CCCCC1)C2CCCCC2,https://pubchem.ncbi.nlm.nih.gov/compound/23563,PubChem,CCN(C1CCCCC1)C1CCCCC1,Train "EU_REACH: 2-methyl-1-[4-(methylsulfanyl)phenyl]-2-(morpholin-4-yl)propan-1-one",,71868-10-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11144/7/4/2/?documentUUID=6d4327de-69b9-4730-bf18-d90b90c8bd9b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C(=O)C1=CC=C(C=C1)SC)N2CCOCC2,https://pubchem.ncbi.nlm.nih.gov/compound/92387,PubChem,CSc1ccc(C(=O)C(C)(C)N2CCOCC2)cc1,Train "EU_REACH: 6-(3-methyloctanamido)hexanoic acid",,71902-23-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11335/7/4/2/?documentUUID=82d1bb14-43b6-42f2-a56d-b2cbda67903d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCC(=O)NCCCCCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/166214,PubChem,CC(C)CCCCCC(=O)NCCCCCC(=O)O,Train "EU_REACH: bis(oxiran-2-ylmethyl) phthalate",,7195-45-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26593/7/4/2/?documentUUID=90a279a7-a025-46d5-99f6-a01044dd82d1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C(O1)COC(=O)C2=CC=CC=C2C(=O)OCC3CO3,https://pubchem.ncbi.nlm.nih.gov/compound/62629,PubChem,O=C(OCC1CO1)c1ccccc1C(=O)OCC1CO1,Train "EU_REACH: 2-(2-phenylphenoxy)ethyl prop-2-enoate",,72009-86-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21708/7/4/2/?documentUUID=fd16dcf8-b564-4604-af40-30b88befa053,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CC(=O)OCCOC1=CC=CC=C1C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/23290047,PubChem,C=CC(=O)OCCOc1ccccc1-c1ccccc1,Train "EU_REACH: β,β-carotene",,7235-40-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25238/7/4/2/?documentUUID=b3e6edfd-930a-4f78-9d8d-4bdaa0de3b64,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C2=C(CCCC2(C)C)C)\C)\C)/C)/C,https://pubchem.ncbi.nlm.nih.gov/compound/5280489,PubChem,CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)C(C)(C)CCC1,Train "EU_REACH: 2-dodecylhexadecan-1-ol",,72388-18-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12621/7/4/2/?documentUUID=517ae07f-4225-4c47-94a7-d201ca152e1f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCC(CCCCCCCCCCCC)CO,https://pubchem.ncbi.nlm.nih.gov/compound/3018340,PubChem,CCCCCCCCCCCCCCC(CO)CCCCCCCCCCCC,Train "EU_REACH: 2-[2-(3-butoxypropyl)-1,1-dioxo-2H-1lambda6,2,4-benzothiadiazin-3-yl]-N-{5-tert-butyl-2-[(2-ethylhexyl)sulfanyl]phenyl}-2-(5,5-dimethyl-2,4-dioxo-1,3-oxazolidin-3-yl)acetamide",,727678-39-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/3364/7/4/2/?documentUUID=6b87b89e-47a3-4b00-90ed-65aa7497b352,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)CSC1=C(C=C(C=C1)C(C)(C)C)NC(=O)C(C2=NC3=CC=CC=C3S(=O)(=O)N2CCCOCCCC)N4C(=O)C(OC4=O)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/20778516,PubChem,CCCCOCCCN1C(C(C(=O)Nc2cc(C(C)(C)C)ccc2SCC(CC)CCCC)N2C(=O)OC(C)(C)C2=O)=Nc2ccccc2S1(=O)=O,Train "EU_REACH: 6-(methylsulfanyl)-N2,N4-di(propan-2-yl)-1,3,5-triazine-2,4-diamine JP_CHRIP: 2,4-Bis(isopropylamino)-6-(methylthio)-s-triazine; N,N'-Diisopropyl-6-(methylthio)-1,3,5-triazine-2,4-diamine; Prometryn","JP_CHRIP: 1,3,5-Triazine-2,4-diamine, N,N'-bis(1-methylethyl)-6-(methylthio)- Acetamide, 2-chloro-N-(2,6-diethylphenyl)-N-(methoxymethyl)-",7287-19-6,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32336/7/4/2/?documentUUID=d5b4db3b-3da9-4c99-ab66-f135f27eb368 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0030e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1), (2) in accordance with the GHS classification guidance for the Japanese government. [Evidence Data] (1) Slight skin irritation was observed in a skin irritation test with rabbits (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015)). (2) Slight irritation was seen in a skin irritation test with rabbits (EPA Pesticide RED (1996), HSDB (Accessed Sep. 2020)).",Provided,"EU_REACH, JP_CHRIP",2,CSc1nc(NC(C)C)nc(NC(C)C)n1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.096A,J-GLOBAL,CSc1nc(NC(C)C)nc(NC(C)C)n1,Train "EU_REACH: unnamed [72901-31-6]",,72901-31-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26032/7/4/2/?documentUUID=00ef2988-dec3-49e5-b113-48e252c3cfa1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCC/C=C/CCCCCCCCNC(=O)CCCCCCC/C=C\CCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/6442040,PubChem,CCCCCCCC/C=C\CCCCCCCC(=O)NCCCCCCCC/C=C/CCCCCCCC,Train "EU_REACH: [2,5-dioxo-3-(prop-2-yn-1-yl)imidazolidin-1-yl]methyl (1R,3R)-2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carboxylate; [2,5-dioxo-3-(prop-2-yn-1-yl)imidazolidin-1-yl]methyl (1R,3S)-2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carboxylate",,72963-72-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33131/7/4/2/?documentUUID=6499f488-a698-475f-97f0-2dd6846b4cc4,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=CC1C(C1(C)C)C(=O)OCN2C(=O)CN(C2=O)CC#C)C,https://pubchem.ncbi.nlm.nih.gov/compound/123622,PubChem,C#CCN1CC(=O)N(COC(=O)C2C(C=C(C)C)C2(C)C)C1=O,Train "JP_CHRIP: O,O-dimethyl phthalimidomethyl S-phosphorodithioate; Phosmet","JP_CHRIP: O,O-Dimethyl phosphorodithioate S-ester with N-(mercaptomethyl) phthalimide O,O-Dimethyl S-phthalimidomethyl phosphorodithioate Phosmet Phosphorodithioic acid, S-((1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl) O,O-dimethyl ester Phosphorodithioic acid, S-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl] O,O-dimethyl ester",732-11-6,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2071e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1) - (4). Because new data (1) - (4) were obtained, the classification result was changed. [Evidence Data] (1) In a skin irritation test with rabbits similar to OECD TG 404, no irritation reactions were seen at 24 hours after application (CLH Report (2015), RAC Background Document (2016)). (2) In a skin irritation test with rabbits according to EPA OPPTS 870.2500, it was not irritating (EPA Pesticides RED (2006)). (3) This substance was not irritating in a skin irritation test with rabbits (Draize test) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012)). (4) This substance was not a skin irritant (HSDB (Access on May 2020)).",Provided,JP_CHRIP,1,COP(=S)(OC)SCN1C(=O)c2ccccc2C1=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.108C,J-GLOBAL,COP(=S)(OC)SCN1C(=O)c2ccccc2C1=O,Train "EU_REACH: L-tryptophan",,73-22-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10835/7/4/2/?documentUUID=53310c87-8d20-45e9-a413-5072e34b1be5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/6305,PubChem,N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O,Train "EU_REACH: 2,4,6-tri-tert-butylphenol",,732-26-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5641/7/4/2/?documentUUID=ee760c18-d3b0-4681-aeba-18b8a3bd4285,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1=CC(=C(C(=C1)C(C)(C)C)O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/12902,PubChem,CC(C)(C)c1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1,Train "EU_REACH: 2-(2-butoxyethoxy)ethyl 2-methylprop-2-enoate",,7328-22-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10356/7/4/2/?documentUUID=d47dd6f7-ab21-446c-b0e3-337dbe6e7fcd,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOCCOCCOC(=O)C(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/81768,PubChem,C=C(C)C(=O)OCCOCCOCCCC,Train "EU_REACH: 1,1'-ethane-1,2-diylbis(4-nitrobenzene)",,736-30-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7759/7/4/2/?documentUUID=66c2c937-84ad-483f-932d-257f238d89a2,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1CCC2=CC=C(C=C2)[N+](=O)[O-])[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/69776,PubChem,O=[N+]([O-])c1ccc(CCc2ccc([N+](=O)[O-])cc2)cc1,Train "EU_REACH: 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid",,7365-45-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13322/7/4/2/?documentUUID=0fe26b68-bc32-4983-a68d-dabde051132d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CN(CCN1CCO)CCS(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/23831,PubChem,O=S(=O)(O)CCN1CCN(CCO)CC1,Train "EU_REACH: 1,1'-(1,3-Phenylenedicarbonyl)diazepan-2-one",,7381-13-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17347/7/4/2/?documentUUID=2729ff26-969f-4c60-8e48-a3d1ab4acb86,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CCC(=O)N(CC1)C(=O)C2=CC(=CC=C2)C(=O)N3CCCCCC3=O,https://pubchem.ncbi.nlm.nih.gov/compound/81857,PubChem,O=C1CCCCCN1C(=O)c1cccc(C(=O)N2CCCCCC2=O)c1,Train "EU_REACH: 7,13-dicyclohexyl-5,15-dimethyl-9,11-dioxa-10-phosphatricyclo[10.4.0.0³,⁸]hexadeca-1(12),3(8),4,6,13,15-hexaen-10-ol",,73912-21-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23944/7/4/2/?documentUUID=757ef9b7-af8b-433f-834b-e6a1055ffc4a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC2=C(C(=C1)C3CCCCC3)OP(OC4=C(C2)C=C(C=C4C5CCCCC5)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/166434,PubChem,Cc1cc2c(c(C3CCCCC3)c1)OP(O)Oc1c(cc(C)cc1C1CCCCC1)C2,Train "EU_REACH: 2-(2H-1,2,3-benzotriazol-2-yl)-6-(2-phenylpropan-2-yl)-4-(2,4,4-trimethylpentan-2-yl)phenol",,73936-91-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15623/7/4/2/?documentUUID=c5c6043b-c3f8-4222-91e6-439ef065e527,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)CC(C)(C)C1=CC(=C(C(=C1)N2N=C3C=CC=CC3=N2)O)C(C)(C)C4=CC=CC=C4,https://pubchem.ncbi.nlm.nih.gov/compound/9803353,PubChem,CC(C)(C)CC(C)(C)c1cc(-n2nc3ccccc3n2)c(O)c(C(C)(C)c2ccccc2)c1,Train "EU_REACH: 2,2-bis[(decanoyloxy)methyl]butyl decanoate; 2,2-bis[(octanoyloxy)methyl]butyl decanoate; 2-[(decanoyloxy)methyl]-2-[(octanoyloxy)methyl]butyl decanoate",,73947-34-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20848/7/4/2/?documentUUID=58669a32-4bf5-4f40-9162-17e9cd99a16e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCC(=O)OCC(CC)(COC(=O)CCCCCCC)COC(=O)CCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/22833312,PubChem,CCCCCCCCCC(=O)OCC(CC)(COC(=O)CCCCCCC)COC(=O)CCCCCCC,Train "NZ_CCID: 1-Decanamine, N-decyl-N-methyl-",,7396-58-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C204482D-7507-48BC-B8C4-5296BA30E615,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCCCCCCCCCN(C)CCCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/81880,PubChem,CCCCCCCCCCN(C)CCCCCCCCCC,Train "JP_CHRIP: Butyl hydroxyacetate",,7397-62-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0041e.html,"JP_CHRIP: On the basis of a ""not irritating"" result in a test using rabbits (OECD TG 404; GLP) (IUCLID (2000)), it was classified as ""Not classified.""",Provided,JP_CHRIP,1,CCCCOC(=O)CO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J39.924H,J-GLOBAL,CCCCOC(=O)CO,Train "EU_REACH: 5,5'-{ethane-1,2-diylbis[thio-1,3,4-thiadiazole-5,2-diyldiazene-2,1-diyl(5-amino-3-tert-butyl-1H-pyrazole-4,1-diyl)]}diisophthalic acid",,741248-63-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21051/7/4/2/?documentUUID=ea91a847-0941-4ca6-9eaa-e6d97a4cede5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1=NN(C(=C1N=NC2=NN=C(S2)SCCSC3=NN=C(S3)N=NC4=C(N(N=C4C(C)(C)C)C5=CC(=CC(=C5)C(=O)O)C(=O)O)N)N)C6=CC(=CC(=C6)C(=O)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/136500903,PubChem,CC(C)(C)c1nn(-c2cc(C(=O)O)cc(C(=O)O)c2)c(N)c1N=Nc1nnc(SCCSc2nnc(N=Nc3c(C(C)(C)C)nn(-c4cc(C(=O)O)cc(C(=O)O)c4)c3N)s2)s1,Train "EU_REACH: 4-methoxy-N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)-2-nitrophenyl]benzamide",,74149-73-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6755/7/4/2/?documentUUID=44f8f04c-be6a-432c-b21e-e83917c39f81,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1CC(=O)NN=C1C2=CC(=C(C=C2)NC(=O)C3=CC=C(C=C3)OC)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/13850880,PubChem,COc1ccc(C(=O)Nc2ccc(C3=NNC(=O)CC3C)cc2[N+](=O)[O-])cc1,Train "EU_REACH: N-[2-amino-4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl]-4-methoxybenzamide",,74149-74-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6756/7/4/2/?documentUUID=e1e17d46-d6ed-4b67-9c4c-0241e5daf8ca,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1CC(=O)NN=C1C2=CC(=C(C=C2)NC(=O)C3=CC=C(C=C3)OC)N,https://pubchem.ncbi.nlm.nih.gov/compound/13850881,PubChem,COc1ccc(C(=O)Nc2ccc(C3=NNC(=O)CC3C)cc2N)cc1,Train "EU_REACH: 4-amino-N-(4-carbamoylphenyl)benzamide",,74441-06-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11122/7/4/2/?documentUUID=4717829d-a4cc-4baf-8e68-8154d7f60913,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1C(=O)NC2=CC=C(C=C2)C(=O)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/3018508,PubChem,NC(=O)c1ccc(NC(=O)c2ccc(N)cc2)cc1,Train "EU_REACH: N-[3,5-bis(2,2-dimethylpropanamido)phenyl]-2,2-dimethylpropanamide",,745070-61-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10725/7/4/2/?documentUUID=00c1f6a2-2c74-417a-9830-61eb2eb1e5ae,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C(=O)NC1=CC(=CC(=C1)NC(=O)C(C)(C)C)NC(=O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/53421640,PubChem,CC(C)(C)C(=O)Nc1cc(NC(=O)C(C)(C)C)cc(NC(=O)C(C)(C)C)c1,Train "NZ_CCID: 9,12-Octadecadienoyl chloride, (9Z,12Z)-",,7459-33-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/26F9D34E-6562-44C4-AE0B-46698BE74678,,,NZ_CCID,1,CCCCCC=CCC=CCCCCCCCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/98987,PubChem,CCCCCC=CCC=CCCCCCCCC(=O)Cl,Train "EU_REACH: (5Z)-5-(phenylmethylidene)imidazolidine-2,4-dione",,74805-60-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5652/7/4/2/?documentUUID=cf88cc61-f25a-4f24-baec-31e2e7684d66,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)/C=C\2/C(=O)NC(=O)N2,https://pubchem.ncbi.nlm.nih.gov/compound/5706042,PubChem,O=C1NC(=O)/C(=C/c2ccccc2)N1,Train "EU_REACH: 2-({9-azatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-10-yl}methyl)-2,3-dihydro-1H-isoindole-1,3-dione",,74860-00-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5205/7/4/2/?documentUUID=9d8ff5f7-9e46-4450-b4e1-58db618ae204,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C2=CC=CC=C2C(=NC3=CC=CC=C31)CN4C(=O)C5=CC=CC=C5C4=O,https://pubchem.ncbi.nlm.nih.gov/compound/11142718,PubChem,O=C1c2ccccc2C(=O)N1CC1=Nc2ccccc2Cc2ccccc21,Train "JP_CHRIP: Methylamine KR_NCIS: Methylamine; Methanamine, Monomethylamine NZ_CCID: Methanamine (methylamine) US_HSDB: Methylamine","JP_CHRIP: Aminomethane Methanamine methylamine, in aqueous solution Monomethylamine NZ_CCID: Aminomethane, Carbinamine, Methanamine, Methylamine, Monomethylamine, R630",74-89-5,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-meti-2004e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4C777067-A395-4629-A8BA-64F4B178F458 US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/810","JP_CHRIP: Although there is no data of skin irritation test with this substance (gas), the solution seems to have a skin corrosion from descriptions that 40% solution causes a necrosis on skin of rabbits (Patty (5th, 2001)) and that ""40% solution causes a necrosis on skin of guinea pig 40%"" (ACGIH (7th, 2001)). It was classified as Category 1with unknown further data and without subdivision. In addition, a solution with 10% or more of this substance concentration can be classified as R34 in the EU classification (EU-Annex I). NZ_CCID: Skin Irritation SPECIES: Guinea Pig RESULT: Corrosive REFERENCE SOURCE: Goffman T, Maguire JR HC; Contact dermatitis 6(2): 140-1 (1980) **PEER REVIEWED** [HSDB] Eye Irritation SPECIES: Rabbit RESULT: Corrosive REFERENCE SOURCE: Clayton, G.D., F.E. Clayton (eds.) Pattys Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994. 1105 **PEER REVIEWED** [HSDB]",,"JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",4,CN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.431A,J-GLOBAL,CN,Train "EU_REACH: 2-ethylhexyl 2-{[1,1'-biphenyl]-4-carbonyl}benzoate",,75005-95-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31361/7/4/2/?documentUUID=070fb787-b3a5-4b50-9849-487140409031,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)C2=CC=C(C=C2)C3=CC=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/135606,PubChem,CCCCC(CC)COC(=O)c1ccccc1C(=O)c1ccc(-c2ccccc2)cc1,Train "JP_CHRIP: Ethanamine NZ_CCID: Ethanamine, anhydrous (ethylamine)","JP_CHRIP: Aminoethane Ethylamine NZ_CCID: 1-Aminoethane, Aminoethane, Ethanamine, Ethylamine, Monoethylamine, R631",75-04-7,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0657e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/815E0EDF-D7A8-4AFB-AE73-7F98E7AFC76B","JP_CHRIP: Based on the descriptions the necrosis of skin and burn (ACGIH (2001) and PATTY (5th, 2001)), and corrosion (IUCLID (2000)) in animal experiments, it was classified as Category 1A-1C. NZ_CCID: Skin Irritation SPECIES: Guinea pig RESULT: Severe Skin Irritation with extensive necrosis and deep scarring from 0.1 mf of 70% solution held in guinea pig skin for 24 hr and prompt necrotic skin burns from 70% dropped on guinea pig skin. REFERENCE SOURCE: [Clayton, G.D., F.E. Clayton (eds.) Pattys Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994. 1116] [HSDB] Eye Irritation SPECIES: RESULT: Severe REFERENCE SOURCE: [Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT06817) (4/25/1958)] [Eye2]: EYE - STANDARD DRAIZE TEST [RTECS]",,"JP_CHRIP, NZ_CCID",2,CCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.437K,J-GLOBAL,CCN,Train "EU_REACH: (methylsulfanyl)methane JP_CHRIP: Dimethyl sulfide","JP_CHRIP: Methylsulphide Thiobismethane",75-18-3,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13649/7/4/2/?documentUUID=b055a0b6-dd88-46ee-afc0-90af881659c0 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2134e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: There are reports that slight irritation was observed after occlusive application of this substance (undiluted) to rabbits for 24 hours (SIDS (2007)), and that when this substance was applied to the skin of rabbits (application time unknown), a primary irritation score of 0.4 (0-8) was obtained, indicating slight irritation (ACGIH (7th, 2004)). In addition, it is described that it is slightly irritating to rabbit skin (PATTY (6th, 2012)). From the above results, it was classified as ""Not classified"" (Category 3 in UN GHS classification). New information was added (SIDS (2007)), and the classification was revised according to the revised GHS classification guidance for the Japanese government.",Provided,"EU_REACH, JP_CHRIP",2,CSC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.443E,J-GLOBAL,CSC,Train "AU_HCIS: 2-aminopropane JP_CHRIP: Isopropylamine NZ_CCID: 2-Propanamine US_HSDB: Isopropylamine","AU_HCIS: isopropylamine 2-Propanamine JP_CHRIP: 1-methylethylamine 2-Aminopropane 2-Propaneamine Isopropylamine NZ_CCID: 1-Methylethylamine, 2-Aminopropane, 2-Propaneamine, 2-Propylamine, Isopropylamine, Monoisopropylamine, sec-Propylamine",75-31-0,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=217 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2120e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6F078C37-326C-4B79-9DE0-3BBFE4A01267 US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/804","JP_CHRIP: Based on the description that in a skin irritation test with rabbits (equivalent to OECD TG 404), necrosis, followed by eschar, occurred within 24 hours after 3-minute application of this substance, and a description that corrosion was seen in both of other two tests with rabbits (application time: 1, 5, 15 minutes or 24 hours) (both from SIDS (2016)), this substance was classified in Category 1A. Besides, this substance is classified as ""Skin Irrit. 2, H315"" in EU CLP classification (ECHA CL Inventory (Access on August 2017)). Based on the information obtained in this investigation, the category was changed. NZ_CCID: Skin Irritation SPECIES: Rabbit RESULT: Corrosive REFERENCE SOURCE: BASF AG Ludwigshafen (70) TSCAT, OTS0542011, Doc-I.D. 88-920003765, 07-17-85, Monsanto Acgric Co. (Intl. Res. & Develop. Corp.) [IUCLID 2000] REMARK: EC Classification: Corrosive (causes burns). Eye Irritation SPECIES: Human RESULT: Vapour: mild corneal edema (usually clearing within 3 or 4 hours). Liquid: very severe eye burns, which may cause permanent visual impairment. REFERENCE SOURCE: [Peer Reviewed] Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) PublicationNo. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981. [HSDB]",Provided,"AU_HCIS, JP_CHRIP, NZ_CCID, US_HSDB",4,CC(C)N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.451F,J-GLOBAL,CC(C)N,Train "EU_REACH: (S)-pyrrolidine-2-carboxamide",,7531-52-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25124/7/4/2/?documentUUID=1e3ecb2c-81f0-4ac4-8185-39c9412dc9a4,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C[C@H](NC1)C(=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/111306,PubChem,NC(=O)[C@@H]1CCCN1,Train "JP_CHRIP: acetyl chloride NZ_CCID: Acetyl chloride US_HSDB: Acetyl chloride","JP_CHRIP: Acetic acid chloride Acetic chloride Ethanoyl chloride NZ_CCID: Acetic acid, chloride, Ethanoyl chloride",75-36-5,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0004e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3AECAFF3-C0BA-47E7-A3A4-944E864DC6F1 US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/662","JP_CHRIP: Cases of skin burns in humans have been documented (HSDB (2003), SITTING (5th ED 2008)), and the substance is classified into R34 by the EU. In addition, it is rated UN Subsidiary Risks 8 according to UN1717. Thus the substance was classified into Category 1. NZ_CCID: Skin Irritation R-PHRASE: R 34 Irritating to eyes. REFERENCE SOURCE: Hoechst AG Frankfurt/Main Clariant GmbH Frankfurt am Main. [IUCLID 2000] REMARK: EC Classification: Corrosive (causes burns). Eye Irritation SPECIES: RESULT: Redness. Pain. Severe deep burns. REFERENCE SOURCE: ICSC 0210, Oct 1995 [INCHEM]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,CC(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.453B,J-GLOBAL,CC(=O)Cl,Train "JP_CHRIP: Dichloro(methy)lsilane KR_NCIS: Silane, dichloromethyl-","JP_CHRIP: Dichloromethylsilane Monomethyldichlorosilane KR_NCIS: Dichloro(methyl)silane; Dichlorohydridomethylsilicon; Dichloromethylsilane; Methyldichlorosilane; Methylsilicon dichloride",75-54-7,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0046e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","JP_CHRIP: There is a report that skin reaction was ""severe"" in a Draize test where 2 mg was applied to rabbits for 24-hour (IUCLID (2000)) and ""highly corrosive"" was produced in an animal test (IUCLID (2000)). In addition, there is a report of ""causes severe skin burns for human"" (HSDB (2006)). The substance was classified into Category 1.",,"JP_CHRIP, KR_NCIS",2,C[SiH](Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J44.081G,J-GLOBAL,C[SiH](Cl)Cl,Train "EU_REACH: 2-methyloxirane",,75-56-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16091/7/4/2/?documentUUID=34c8823d-505b-4d14-ab3d-6aab8298c9f8,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1CO1,https://pubchem.ncbi.nlm.nih.gov/compound/6378,PubChem,CC1CO1,Train "NZ_CCID: Cyclohexanamine, N-cyclohexyl-N-methyl-",,7560-83-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/027576ED-75F0-4AA4-9ECB-B0FFBFBBE43C,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CN(C1CCCCC1)C2CCCCC2,https://pubchem.ncbi.nlm.nih.gov/compound/24210,PubChem,CN(C1CCCCC1)C1CCCCC1,Train "EU_REACH: 1,1,1,3,4,4,4-heptafluoro-3-(trifluoromethyl)butan-2-one",,756-12-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31606/7/4/2/?documentUUID=989d47b9-2232-4492-8361-4f8f0714d755,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(=O)(C(C(F)(F)F)(C(F)(F)F)F)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/14175377,PubChem,O=C(C(F)(F)F)C(F)(C(F)(F)F)C(F)(F)F,Train "EU_REACH: 1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoromethyl)pentan-3-one",,756-13-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19473/7/4/2/?documentUUID=db9c868f-5288-4658-a437-4579282d50bc,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(=O)(C(C(F)(F)F)(C(F)(F)F)F)C(C(F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/2782408,PubChem,O=C(C(F)(F)C(F)(F)F)C(F)(C(F)(F)F)C(F)(F)F,Train "NZ_CCID: 2-Propanamine, 2-methyl-","NZ_CCID: 1,1-Dimethylethanamine, 1,1-Dimethylethylamine, 2-Amino-2-methylpropane, 2-Aminoisobutane, 2-Methyl-2-aminopropane, 2-Methyl-2-propanamine, Erbumine, Trimethylaminomethane, t-Butylamine, tert-Butylamine",75-64-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E180BC1B-115A-4245-9914-88E350ADAEC1,"NZ_CCID: Skin Irritation UN CLASS: Packing Group II Eye Irritation R PHRASE: R 35 [Company Data]",,NZ_CCID,1,CC(C)(C)N,https://pubchem.ncbi.nlm.nih.gov/compound/6385,PubChem,CC(C)(C)N,Train "JP_CHRIP: tert-Butyl mercaptan","JP_CHRIP: Benzenemethanethiol tert-Butyl mercaptan",75-66-1,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-0024e.html,"JP_CHRIP: As for a 4-hour application in skin irritation tests (corresponding to OECD TG 404 and OPPTS 870.2500), it is reported that it was mildly irritating (SIDS (2012)) and that it was not irritating (ECHA registration dossier (Access on December 2017)). Also, there are descriptions that mild irritation was observed in the 24-hour application test (SIDS (2012)), and that mild irritation or mild erythema and discoloration at the application site were observed although the application time was unknown (PATTY (6th, 2012)). Therefore, this substance was considered to have mild irritancy and it was classified as ""Not Classified"" (Category 3 in UN GHS classification), to which ""mild irritation"" is considered to correspond in the GHS classification guidance for Japanese government.",Provided,JP_CHRIP,1,CC(C)(C)S,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.161K,J-GLOBAL,CC(C)(C)S,Train "JP_CHRIP: methanesulphonic acid KR_NCIS: Methanesulfonic acid NZ_CCID: Methanesulphonic acid","JP_CHRIP: Methanesulfonic acid",75-75-2,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0138e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/69F8BEA0-B5E3-4FB8-A93E-7E368E23BB5C","JP_CHRIP: Since it is documented that in an irritation test with 1-h exposure to mouse skin, it was corrosive (PATTY (5th, 2001)), and in an irritation test using guinea pigs, it resulted in numerous small lesions resembling acid burns (PATTY (5th, 2001)), the substance was classified into Category 1. NZ_CCID: Skin Irritation REMARK: >1 but <4 hr: Corrosive (PGIII) REFERENCE SOURCE: IUCLID Data Set Eye Irritation SPECIES: Rabbit RESULT: Corrosive: risk of serious damage to eyes REFERENCE SOURCE: IUCLID Data Set",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,CS(=O)(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.465F,J-GLOBAL,CS(=O)(=O)O,Train "EU_REACH: 3-[(3-sulfanylpropanoyl)oxy]-2,2-bis({[(3-sulfanylpropanoyl)oxy]methyl})propyl 3-sulfanylpropanoate",,7575-23-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10120/7/4/2/?documentUUID=433dcae7-1400-4bc4-a1cc-26a3c7fd1ed8,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CS)C(=O)OCC(COC(=O)CCS)(COC(=O)CCS)COC(=O)CCS,https://pubchem.ncbi.nlm.nih.gov/compound/82056,PubChem,O=C(CCS)OCC(COC(=O)CCS)(COC(=O)CCS)COC(=O)CCS,Train "EU_REACH: tetramethylsilane",,75-76-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14468/7/4/2/?documentUUID=0aeb8566-8767-4249-b76c-989d33775d5d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6396,PubChem,C[Si](C)(C)C,Train "JP_CHRIP: Chlorotrimethylsilane NZ_CCID: Silane, chlorotrimethyl-","JP_CHRIP: chlorotrimethylsilane Chlorotrimethylsilicane Trimethyl silyl chloride NZ_CCID: Monochlorotrimethylsilicon, Trimethylsilyl chloride",75-77-4,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0058e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0036D01A-4B62-4627-B792-16E149A31F1B","JP_CHRIP: There is a report of ""Necrosis, accompanied by severe erythema, moderate edema, and desquamation was observed within 1-hour after application of 0.5 mL to the skin of rabbits for 4-hour. The effects persisted through 1-week observation period. Although the skin primary irritation index was 2.2/8.0 (HSDB (2007)), the substance was classified into Category 1 based on a report of ""highly corrosive"" in another rabbit test (IUCLID (2000)) and a report of ""corrosive to the skin"" (HSDB (2007)). NZ_CCID: Skin Irritation SPECIES: Rabbit RESULT: Highly corrosive. REFERENCE SOURCE: Elf Atochem UK Ltd Newbury - Berkshire RG 13 4 LW (26) [IUCLID 2000] Eye Irritation SPECIES: Rabbit RESULT: Highly corrosive. REFERENCE SOURCE: DOW Corning Europe La Hulpe (27) [IUCLID 2000] REMARK: EC Classification = Risk of serious damage to the eyes.",,"JP_CHRIP, NZ_CCID",2,C[Si](C)(C)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.466D,J-GLOBAL,C[Si](C)(C)Cl,Train "JP_CHRIP: Dichloro(dimethyl)silane NZ_CCID: Silane, dichlorodimethyl-","JP_CHRIP: Chlorodimethylsilane NZ_CCID: Dichlorodimethyl silane, Dimethyldichlorosilane",75-78-5,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0054e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FD91E8A4-D757-4E4A-BE6C-F879266F2EA1","JP_CHRIP: Based on a result of ""corrosive"" in a rabbit test (IUCLID (2002)) and ""contact with liquid causes severe burns of the skin"" (HSDB (2002)), the substance was classified into Category 1. NZ_CCID: Skin Irritation Based on sub risk 8 PG II [UNTDGMR] Eye Irritation SPECIES: Rabbit RESULT: Corrosive. Severe damage of the cornea and lids. REFERENCE SOURCE: [Peer Reviewed] [Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986. 224] [HSDB]",,"JP_CHRIP, NZ_CCID",2,C[Si](C)(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.467B,J-GLOBAL,C[Si](C)(Cl)Cl,Train "JP_CHRIP: Trichloro(methyl)silane NZ_CCID: Silane, trichloromethyl-","JP_CHRIP: Trichloromethylsilane NZ_CCID: Methyltrichlorosilane, Trichloromethylsilane, trichloro(methyl)silane",75-79-6,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0057e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A46368C7-36B8-4DA8-8F19-FA7CB121916A","JP_CHRIP: Based on a result of ""corrosive"" in a rabbit test (IUCLID (2000)) and ""causes severe skin burns"" as a human health effects (HSDB (2007)), the substance was classified into Category 1. As relevant information, in EU classification, the substance is classified into Xi: R36/37/38 (EU-Annex I (access on Aug. 2009)). NZ_CCID: Skin Irritation SPECIES: RESULT: Corrosive REFERENCE SOURCE: Rhone-Poulenc Chimie Courbevoie Cedex; Registry of Toxic Effects of Chemical Substances [iuclid 2000] Eye Irritation SPECIES: Rabbit RESULT: Cause severe burns of cornea and eyelids. REFERENCE SOURCE: [Lefaux, R. Practical Toxicology of Plastics. Cleveland: CRC Press Inc., 1968. 109]**PEER REVIEWED** [HSDB]",,"JP_CHRIP, NZ_CCID",2,C[Si](Cl)(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J54.325J,J-GLOBAL,C[Si](Cl)(Cl)Cl,Train "AU_HCIS: Hydroperoxide, 1,1-dimethylethyl JP_CHRIP: tert-Butyl hydroperoxide NZ_CCID: Hydroperoxide, 1,1-dimethylethyl, 70% aqueous solution US_HSDB: tert-Butyl hydroperoxide","AU_HCIS: tert-butyl hydroperoxide 1,1-dimethylethyl hydroperoxide 2-hydroperoxy-2-methylpropane Perbutyl H TBHP JP_CHRIP: tert-Butyl-hydroperoxide 1,1-Dimethylethylhydroxiperoxide 2-Hydroperoxy-2-methylpropane Hydroperoxide, 1,1-dimethylethyl tert-Butyl hydroperoxide tert-Butylhydroperoxide NZ_CCID: tert-Butyl hydroperoxide",75-91-2,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5493 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2058e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DB51077E-DE08-40B3-A86A-0BB623CA787F US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/837","JP_CHRIP: Based on reports that in skin irritation tests with rabbits, corrosivity or severe irritation with necrosis was observed in all of the three tests (EU-RAR (2006)), it was classified in Category 1. NZ_CCID: Skin Irritation SPECIES: Rabbit RESULT: Corrosive REFERENCE SOURCE: RCO Chemical Europe, Inc. Maidenhead, Berkshire (28) Test Species/Strain: Albino Rabbit-New Zealand, White. (29) W. E. Field (1981). Tertiary Butyl Hydroperoxide (70%) - Primary Skin Irritation Study in Rabbits. Chemicals, Drugs, and Cosmetics Research, Inc. Study No. CDC-AR-003-81 (client ARCO Chemical Company), report dated June 29, 1981. Unpublished data [IUCLID 2000] Eye Irritation SPECIES: Rabbit RESULT: Highly irritating REFERENCE SOURCE: ARCO Chemical Europe, Inc. Maidenhead, Berkshire (32) W. E. Field (1981). Tertiary Butyl Hydroperoxide (70%) - Acute Eye Irritation Study in Albino Rabbits. Chemicals, Drugs, and Cosmetics Research, Inc. Study No. CDC-AR-002-81 (client ARCO Chemical Company), reported dated June 5, 1981. Unpublished data [IUCLID 2000] REMARK: EC Classificaton = Risk of serious damage to eyes",,"AU_HCIS, JP_CHRIP, NZ_CCID, US_HSDB",4,CC(C)(C)OO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.397C,J-GLOBAL,CC(C)(C)OO,Train "JP_CHRIP: Trichloro(vinyl)silane NZ_CCID: Trichlorovinylsilane",,75-94-5,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0019e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/40A9A9DD-3785-4F8C-8299-664C8EB71466","JP_CHRIP: Based on reports of ""corrosive"" in a skin primary irritation test with rabbits (IUCLID (2000)), and ""corrosive"" in another test with rabbits (IUCLID (2000)), the substance was classified into Category 1. As relevant information, in EU classification, the substance is classified into C; R34. NZ_CCID: Skin Irritation R PHRASE: R 35 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,"JP_CHRIP, NZ_CCID",2,Cl[Si](Cl)(Cl)C=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.505K,J-GLOBAL,C=C[Si](Cl)(Cl)Cl,Train "JP_CHRIP: 3,4-Dichloro-1-butene","JP_CHRIP: 3,4-dichloro-1-butene",760-23-6,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0047e.html,"JP_CHRIP: In the 4-hour rabbit test (OECD TG404, GLP-compliant), application of 0.5 ml of the undiluted test substance for three animals caused slightly irritating with erythema (grade 1 or 2) until 72 hours after removal of patch in all animals. And the mean scores of erythema or edema at 24, 48 and 72 hours after removal of the patch were less than 2.3 (SIDS (2001)). Based on the document, the substance was classified as ""Not classified"" in the JIS classification (corresponding to Category 3 in the UN-GHS classification).",Provided,JP_CHRIP,1,ClCC(Cl)C=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.728K,J-GLOBAL,C=CC(Cl)CCl,Train "NZ_CCID: Trichloroacetyl chloride",,76-02-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9FADD646-63DF-407C-B5F3-A800A3525013,"NZ_CCID: Skin Irritation R PHRASE: R 35 [Company Data] Eye Irritation R PHRASE: R 35 [Company Data]",,NZ_CCID,1,C(=O)(C(Cl)(Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/6420,PubChem,O=C(Cl)C(Cl)(Cl)Cl,Train "AU_HCIS: TCA (ISO) JP_CHRIP: Trichloroacetic acid KR_NCIS: Trichloroacetic acid NZ_CCID: Trichloroacetic acid","JP_CHRIP: Aceto-caustin TCA Trichloroethanoic acid NZ_CCID: Aceto-caustin, Acetic acid, trichloro-, TCA, Trichloracetic acid, Trichloroacetate, Trichloroethanoic acid",76-03-9,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4337 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-2011e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/55F75828-C966-4DF7-AE25-550132752277","JP_CHRIP: There is a result of corrosive to the skin of rabbits (SIDS (access on April. 2009)). In another rabbit test, there are results of ""slight irritation"" after application of 0.21 mg and ""severe irritation"" after application of 3.5 mg (BUA 167 (1995)). Additionally, it has been reported that depending upon concentration and duration of contact, the substance can produce burns (ACGIH (2001)). Based on these information and a pH of < 1 (900 g/L, 20 degC) (IUCLID (2000)), the substance was classified into Category 1. As relevant information, the substance is classified into C; R35 in EU classification. NZ_CCID: Skin Irritation SPECIES: RESULT: It is a corrosive organic acid which rapidly penetrates and ""fixes"" tissues. Systemic effects are presumably secondary to GI damage and to acidosis, not due to toxicity (i.e. simple salts are not hazardous). REFERENCE: [Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p. II-103]**PEER REVIEWED** [HSDB] Eye Irritation SPECIES: RESULT: It is a corrosive organic acid which rapidly penetrates and ""fixes"" tissues. Systemic effects are presumably secondary to GI damage and to acidosis, not due to toxicity (i.e. simple salts are not hazardous). REFERENCE: [Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p. II-103]**PEER REVIEWED**[HSDB]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID",4,OC(=O)C(Cl)(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.400G,J-GLOBAL,O=C(O)C(Cl)(Cl)Cl,Train "JP_CHRIP: Trifluoroacetic acid NZ_CCID: Trifluoroacetic acid","JP_CHRIP: Acetic acid, trifluoro- Perfluoroacetic acid",76-05-1,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0142e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C6566382-DE45-45E2-805C-FDC81EB750CD","JP_CHRIP: From the information that this substance has a pH of 1 (10 g/L) (GESTIS (Access on Nov. 2011)), it was classified in Category 1. Besides, it is classified in C; R35 in EU classification (EC-JRC (ESIS) (Access on Nov. 2011)). NZ_CCID: Skin Irritation R PHRASE: R 35 [Company Data] Eye Irritation R PHRASE: R 35 [Company Data]",,"JP_CHRIP, NZ_CCID",2,OC(=O)C(F)(F)F,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.401E,J-GLOBAL,O=C(O)C(F)(F)F,Train "JP_CHRIP: 2-Ethylhexanoyl chloride","JP_CHRIP: 2-Ethylhexanoyl chloride",760-67-8,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0035e.html,"JP_CHRIP: It was classified in Category 1 from a result as ""corrosive"" in a test using rabbits (OECD TG404, GLP compliance) (IUCLID (2000)). Besides, another rabbit test reports that necrosis was observed 72 hours and 7 days after application (Directive 84/449/EEC B.4, GLP compliance) (IUCLID (2000)).",Provided,JP_CHRIP,1,CCCCC(CC)C(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J150.162C,J-GLOBAL,CCCCC(CC)C(=O)Cl,Train "EU_REACH: 2-propynyl-butylcarbamate",,76114-73-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12315/7/4/2/?documentUUID=1045670c-9e91-4b66-b0f6-a791a27ab2ab,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCNC(=O)OCC#C,https://pubchem.ncbi.nlm.nih.gov/compound/10877354,PubChem,C#CCOC(=O)NCCCC,Train "EU_REACH: 616-307-3",,76205-19-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27100/7/4/2/?documentUUID=f1cd3aee-6590-4a76-8280-f69d1845acc2,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1N2C=CC(=O)N2)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/11356026,PubChem,O=c1ccn(-c2ccc(Cl)cc2)[nH]1,Train "EU_REACH: decanoyl decaneperoxoate",,762-12-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5297/7/4/2/?documentUUID=692adb48-9c50-4adc-ba00-250cabbe0b6f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCC(=O)OOC(=O)CCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/69802,PubChem,CCCCCCCCCC(=O)OOC(=O)CCCCCCCCC,Train "NZ_CCID: 2-Chloropropionyl chloride",,7623-09-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F6CA10ED-7755-47ED-9907-FA0539BCF9A9,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C(=O)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/111019,PubChem,CC(Cl)C(=O)Cl,Train "NZ_CCID: Dimethyl acetylenedicarboxylate",,762-42-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1D464ACD-E0FD-47CF-9100-162F5EC966AB,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,COC(=O)C#CC(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/12980,PubChem,COC(=O)C#CC(=O)OC,Train "EU_REACH: (2R,3R,4R,5S)-6-(dimethylamino)hexane-1,2,3,4,5-pentol",,76326-99-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18179/7/4/2/?documentUUID=c3191a12-02d1-4a9a-8bdf-b433b2dcdc05,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C)C[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/11564307,PubChem,CN(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO,Train "JP_CHRIP: 2-Butene, 1,4-dichloro- NZ_CCID: 2-Butylene dichloride","JP_CHRIP: 1,4-Dichloro-2-butene NZ_CCID: 2-Butene, 1,4-dichloro-",764-41-0,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-2029e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8338B2DC-1229-4D51-8042-BD9984B882A8","JP_CHRIP: The treatment of the forearms of human volunteers for 0.5 to 1 hour with the undiluted substance caused marked erythema, edema, and development of blisters (SIDS (2006)). Liquid and vapors of the substance caused extremely corrosive to human skin (SIDS (2006)). Based on the information, the substance was classified as Category 1. NZ_CCID: Skin Irritation REMARK: Original Corr82 Classification: Corr82RD. Tox63 Classification: Tox63RD Skin absorption. [NZ WES 2001] Eye Irritation R-PHRASE: R 34. [ECB]",,"JP_CHRIP, NZ_CCID",2,ClCC=CCCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.024D,J-GLOBAL,ClCC=CCCl,Train "EU_REACH: N-(2-hydroxyethyl)prop-2-enamide",,7646-67-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33694/7/4/2/?documentUUID=2421b2c3-50e9-41e4-8cb7-4d92c5aee492,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CC(=O)NCCO,https://pubchem.ncbi.nlm.nih.gov/compound/193628,PubChem,C=CC(=O)NCCO,Train "NZ_CCID: Nonanoyl chloride",,764-85-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0C514427-0911-4AD2-ADAB-0567AF3C7B63,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCCCCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/69819,PubChem,CCCCCCCCC(=O)Cl,Train "EU_REACH: {2-[2-(ethenyloxy)ethoxy]ethoxy}ethene",,764-99-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11118/7/4/2/?documentUUID=32175c7c-fc1f-406c-97df-777b04a22f58,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=COCCOCCOC=C,https://pubchem.ncbi.nlm.nih.gov/compound/12998,PubChem,C=COCCOCCOC=C,Train "EU_REACH: 3,6,9,12-tetraoxatetradeca-1,13-diene",,765-12-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10352/7/4/2/?documentUUID=b60d6f4a-929a-4b14-9ac3-b0dc6316c185,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=COCCOCCOCCOC=C,https://pubchem.ncbi.nlm.nih.gov/compound/3033992,PubChem,C=COCCOCCOCCOC=C,Train "NZ_CCID: Cyclopropylamine",,765-30-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/70475B82-FDF8-48BE-B608-87FF41C4A025,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CC1N,https://pubchem.ncbi.nlm.nih.gov/compound/69828,PubChem,NC1CC1,Train "EU_REACH: 2-ethylhexyl 2-sulfanylacetate JP_CHRIP: 2-Ethylhexyl thioglycolate","JP_CHRIP: 2-ethylhexyl mercaptoacetate 2-Ethylhexyl mercaptoacetate; 2-Ethylhexyl mercaptoacetate; 2-Ethylhexyl thioglycolate 2-ethylhexyl thioglycolate",7659-86-1,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13385/7/4/2/?documentUUID=0c3d17b1-e1c3-47f4-a848-27c7dfe0185d JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0147e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: In the rabbit test (OECD TG404, GLP-compliant), average scores of each 3 animals at 24, 48 and 72 hours after application were 1.3, 1.7, and 1.3 for erythema, 0.0, 0.0, and 0.3 for edema, respectively, and the symptoms were all reversible within 6 days and 3 days respectively. Thus, the substance was concluded as slightly irritating (IUCLID (2000)). Because the average score of erythema or edema was less than 1.5 in at least two of three animals, the substance was classified as ""Not classified"".",Provided,"EU_REACH, JP_CHRIP",2,CCCCC(CC)COC(=O)CS,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J150.356A,J-GLOBAL,CCCCC(CC)COC(=O)CS,Train "NZ_CCID: Piperidine, 1-ethyl-","NZ_CCID: 1-Ethylpiperidine",766-09-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A64BAB75-D32E-4AAC-92C9-AB79E3063A7F,"NZ_CCID: Skin Irritation SPECIES: RESULT: Severe burns. REEFERENCE SOURCE: [MSDS] Eye Irritation SPECIES: RESULT: Can cause severe burns leading to permanent damage. REFERENCE SOURCE: [NJHS]",,NZ_CCID,1,CCN1CCCCC1,https://pubchem.ncbi.nlm.nih.gov/compound/13007,PubChem,CCN1CCCCC1,Train "NZ_CCID: 1-(Bromomethyl)-3-chlorobenzene",,766-80-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/345D64EB-32AC-4074-BF1D-FD9424CAA2A3,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC(=CC(=C1)Cl)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/69838,PubChem,Clc1cccc(CBr)c1,Train "EU_REACH: 2-(4-{4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butanoyl}phenyl)-2-methylpropanoic acid",,76811-98-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6505/7/4/2/?documentUUID=0d63ea2e-b63c-4474-b6a0-50146e9544ba,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C1=CC=C(C=C1)C(=O)CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/9935699,PubChem,CC(C)(C(=O)O)c1ccc(C(=O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,Train "NZ_CCID: Chlorotriphenylsilane","NZ_CCID: triphenylsilyl chloride",76-86-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F47F505C-8984-4379-AA6C-596F759A9939,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)[Si](C2=CC=CC=C2)(C3=CC=CC=C3)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/6458,PubChem,Cl[Si](c1ccccc1)(c1ccccc1)c1ccccc1,Train "EU_REACH: bis(ethenyldimethylsilyl)amine",,7691-02-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5675/7/4/2/?documentUUID=d0eb5a4d-f291-4152-9581-3f75b0ccada4,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](C)(C=C)N[Si](C)(C)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/82126,PubChem,C=C[Si](C)(C)N[Si](C)(C)C=C,Train "NZ_CCID: 4-Nitrophenyl chloroformate",,7693-46-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/099E9397-8468-4947-93F2-7EC65102EF98,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1[N+](=O)[O-])OC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/82129,PubChem,O=C(Cl)Oc1ccc([N+](=O)[O-])cc1,Train "EU_REACH: phenyl dichlorophosphate NZ_CCID: Phenyl dichlorophosphate",,770-12-7,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20440/7/4/2/?documentUUID=3eea564c-d01c-4e0a-86b8-5a2fa86332d3 NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A45219D1-39BA-409F-8BC2-2399D99198F3","EU_REACH: Experimental study (OECD TG 404, GLP) NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",Provided,"EU_REACH, NZ_CCID",2,C1=CC=C(C=C1)OP(=O)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/13038,PubChem,O=P(Cl)(Cl)Oc1ccccc1,Train "JP_CHRIP: 1-Phenoxy-2-propanol","JP_CHRIP: 1-Phenoxy-2-propanol; 1-Phenoxy-2-propanol",770-35-4,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-0010e.html,"JP_CHRIP: It was classified as ""Not classified"" because no irritation was observed in a skin irritation test with rabbits according to OECD TG 404 (SIDS (2006))",Provided,JP_CHRIP,1,CC(O)COc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J47.817B,J-GLOBAL,CC(O)COc1ccccc1,Train "JP_CHRIP: 2-Amino-4-[hydroxy(methyl)phosphoryl]butanoic acid,ammonium salt; Glufosinate-ammonium",,77182-82-2,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-0007e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1), (2). [Evidence Data] (1) In skin irritation tests with rabbits on this substance by 24-hour semi-occlusive application or by methods according to OECD TG 404, only erythema was observed in part of the animals, and it was judged as not irritating (JMPR (2012), Japan Crop Protection Association Fed. Chem. Toxic. vol.28 no.5 (1990)). (2) No irritation was observed in an eye irritation test and a skin irritation test with rabbits on this substance (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2011)).",Provided,JP_CHRIP,1,CP(=O)(O)CCC(N)C(=O)O[N+],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J309.363H,J-GLOBAL,CP(=O)(O)CCC(N)C(=O)O[N+],Train "NZ_CCID: 2,4,6-Trimethylbenzenesulphonyl chloride","NZ_CCID: 2-mesitylenesulfonyl chloride",773-64-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/764121D3-2A9C-41D3-B105-3E3341407B5A,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC1=CC(=C(C(=C1)C)S(=O)(=O)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/13046,PubChem,Cc1cc(C)c(S(=O)(=O)Cl)c(C)c1,Train "NZ_CCID: 2-Bromo-4-nitrotoluene",,7745-93-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/034186FF-9449-4B71-8A52-32ACE8E33682,,,NZ_CCID,1,CC1=C(C=C(C=C1)[N+](=O)[O-])Br,https://pubchem.ncbi.nlm.nih.gov/compound/82189,PubChem,Cc1ccc([N+](=O)[O-])cc1Br,Train "JP_CHRIP: Hexachlorocyclopentadiene KR_NCIS: Hexachlorocyclopentadiene","JP_CHRIP: 1,2,3,4,5,5-Hexachloro-1,3-cyclopentadiene 1,2,3,4,5,5-Hexachlorocyclopenta-1,3-diene HCCPD Hexachlorocyclopentadiene Perchlorocyclopentadiene KR_NCIS: Perchlorocyclopentadiene; Hexachloro-1,3-cyclopentadiene; 1,2,3,4,5,5-Hexachloro-1,3-Cyclopentadiene; Graphlox",77-47-4,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2086e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","JP_CHRIP: In a skin irritation test with rabbits, it was found corrosive in tests in which the undiluted liquid or a 10% aqueous solution of this substance was applied (EU-RAR (2007)). In addition, there are reports that it was also found corrosive in a test in which 40-90% aqueous solutions of this substance were applied to guinea pigs (EU-RAR (2007)) and that there was moderate to severe primary irritation on rabbit skin (EHC 120 (1991)). In humans, there is a report that it was irritating to the skin (IRIS (2001), EU-RAR (2007)). From the above, based on the ""corrosive"" results in rabbits, it was classified in Category 1. Besides, this substance was classified in ""C; R34"" in the EU DSD classification, in ""Skin Corr. 1B H314"" in the EU CLP classification. Information was added, and the category was changed.",,"JP_CHRIP, KR_NCIS",2,ClC1=C(Cl)C(Cl)(Cl)C(=C1Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.949F,J-GLOBAL,ClC1=C(Cl)C(Cl)(Cl)C(Cl)=C1Cl,Train "NZ_CCID: 1,3-Dibromo-5,5-dimethylhydantoin",,77-48-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E81547F1-5A68-4290-B24C-239E70B42266,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC1(C(=O)N(C(=O)N1Br)Br)C,https://pubchem.ncbi.nlm.nih.gov/compound/6479,PubChem,CC1(C)C(=O)N(Br)C(=O)N1Br,Train "EU_REACH: (2-ethoxy-1-methyl-2-oxoethyl)-5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate",,77501-63-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6560/7/4/2/?documentUUID=f46e7653-b19a-43ec-9bd8-8269c371f3a5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C(C)OC(=O)C1=C(C=CC(=C1)OC2=C(C=C(C=C2)C(F)(F)F)Cl)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/62276,PubChem,CCOC(=O)C(C)OC(=O)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-],Train "EU_REACH: 2-methylprop-1-ene",,7756-94-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5319/7/4/2/?documentUUID=6faff624-dd19-4b52-8885-d83a809ec126,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=CC(C)(C)CC(C)(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/170244,PubChem,CC(C)=CC(C)(C)CC(C)(C)C,Train "EU_REACH: 2-{[2-hydroxy-5-methyl-3-(1-methylcyclohexyl)phenyl]methyl}-4-methyl-6-(1-methylcyclohexyl)phenol",,77-62-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22349/7/4/2/?documentUUID=178e25f8-8a7c-473e-b701-7683ea2399f5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C(=C1)C2(CCCCC2)C)O)CC3=C(C(=CC(=C3)C)C4(CCCCC4)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/6486,PubChem,Cc1cc(Cc2cc(C)cc(C3(C)CCCCC3)c2O)c(O)c(C2(C)CCCCC2)c1,Train "NZ_CCID: Bromodiphenylmethane","NZ_CCID: diphenylmethyl bromide",776-74-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/58B7B1D2-6879-44BB-820A-E3BD64346A5F,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)C(C2=CC=CC=C2)Br,https://pubchem.ncbi.nlm.nih.gov/compound/236603,PubChem,BrC(c1ccccc1)c1ccccc1,Train "EU_REACH: 3-butyl-1-[4-({4-[(butylcarbamoyl)amino]phenyl}methyl)phenyl]urea",,77703-56-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13359/7/4/2/?documentUUID=f924baf8-521f-4986-a8ba-b7b61f3f1b7e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCNC(=O)NC1=CC=C(C=C1)CC2=CC=C(C=C2)NC(=O)NCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/3576105,PubChem,CCCCNC(=O)Nc1ccc(Cc2ccc(NC(=O)NCCCC)cc2)cc1,Train "EU_REACH: tris(2-methylnonacosyl) phosphite",,77745-66-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14205/7/4/2/?documentUUID=b6cc35a4-48f7-4316-be66-9eee5733f8a6,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCCCCCCOP(OCCCCCCCCCCC(C)C)OCCCCCCCCCCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/22630279,PubChem,CC(C)CCCCCCCCCCOP(OCCCCCCCCCCC(C)C)OCCCCCCCCCCC(C)C,Train "NZ_CCID: Phosphorodichloridic acid, 4-nitrophenyl ester",,777-52-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EC33D186-2158-4A4A-9BB4-3B32CA997777,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC(=CC=C1[N+](=O)[O-])OP(=O)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/69898,PubChem,O=[N+]([O-])c1ccc(OP(=O)(Cl)Cl)cc1,Train "JP_CHRIP: Divinyl sulfone NZ_CCID: Divinyl sulphone","JP_CHRIP: Divinyl sulfone NZ_CCID: vinyl sulfone",77-77-0,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0143e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/497E866C-E77A-4D92-AA8F-953927ECFC90","JP_CHRIP: The substance was classified as Category 1 based on the document that application of the substance to rabbit skin caused necrosis (PATTY, 5th (2001)). NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,C=CS(=O)(=O)C=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.478H,J-GLOBAL,C=CS(=O)(=O)C=C,Train "AU_HCIS: dimethyl sulphate JP_CHRIP: Dimethyl sulfate KR_NCIS: Dimethyl sulfate NZ_CCID: Dimethyl sulphate","AU_HCIS: dimethyl sulfate JP_CHRIP: Dimethyl sulfate Dimethyl monosulfate dimethyl sulphate DMS Sulfuric acid dimethyl ester Sulfuric acid, dimethyl ester KR_NCIS: Sulfuric acid dimethyl ester NZ_CCID: Dimethyl monosulfate, Methyl sulfate, Sulfuric acid, dimethyl ester",77-78-1,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1420 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0619e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0B8B5C25-87C9-478A-AEDB-5896241CF2A2","JP_CHRIP: Based on descriptions that it has strong irritative and corrosive effect on human skin (CERI Hazard Data (1999)) and that necrosis was seen in rabbit skin application test (CERI Hazard Data (1999), EU-RAR (2002)), it was classified as Category 1A-1C. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID",4,COS(=O)(=O)OC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.823A,J-GLOBAL,COS(=O)(=O)OC,Train "NZ_CCID: Hexahydro-1,3,5-triethyl-s-triazine",,7779-27-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2A03FCDE-A27E-4EAC-9C76-BFFF220AB917,"NZ_CCID: Skin Irritation R PHRASE: R 35 [Company Data] Eye Irritation R PHRASE: R 41[Company Data]",,NZ_CCID,1,CCN1CN(CN(C1)CC)CC,https://pubchem.ncbi.nlm.nih.gov/compound/24512,PubChem,CCN1CN(CC)CN(CC)C1,Train "EU_REACH: 2,2'-[Ethylenebis(oxyphenyl-2,1-eneazo)]bis[N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxobutyramide",,77804-81-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14248/7/4/2/?documentUUID=76110feb-15db-4282-93c7-3797a77f89a0,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC2=C(C=C1)NC(=O)N2)N=NC3=CC=CC=C3OCCOC4=CC=CC=C4N=NC(C(=O)C)C(=O)NC5=CC6=C(C=C5)NC(=O)N6,https://pubchem.ncbi.nlm.nih.gov/compound/166497,PubChem,CC(=O)C(N=Nc1ccccc1OCCOc1ccccc1N=NC(C(C)=O)C(=O)Nc1ccc2[nH]c(=O)[nH]c2c1)C(=O)Nc1ccc2[nH]c(=O)[nH]c2c1,Train "EU_REACH: dichloro(3-chloropropyl)methylsilane",,7787-93-1,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11206/7/4/2/?documentUUID=178ecaf1-0774-4a73-a85f-6b56f501b26a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](CCCCl)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/82235,PubChem,C[Si](Cl)(Cl)CCCCl,Train "EU_REACH: 2-chloro-1-fluoro-4-(trifluoromethyl)benzene",,78068-85-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27506/7/4/2/?documentUUID=209cd6c1-58e0-43fa-aa20-43da89c1374b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C=C1C(F)(F)F)Cl)F,https://pubchem.ncbi.nlm.nih.gov/compound/157153,PubChem,Fc1ccc(C(F)(F)F)cc1Cl,Train "JP_CHRIP: Triethyl phosphate","JP_CHRIP: Ethyl phosphate TEP Triethoxyphosphine oxide Triethyl phosphate",78-40-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0109e.html,"JP_CHRIP: Moderate irritation was noted in 1 of 3 tested animals in the animal experiment (OECD TG 404, GLP-compliant), but SIDS concluded that the substance was not a skin irritant in accordance with guideline (SIDS (Access on Nov. 2010)). The substance caused slight irritation to guinea pig, but caused non irritation to rabbit (BUA 37 (1989)). Based on these documents, the substance was classified as ""Not classified"".",Provided,JP_CHRIP,1,CCOP(=O)(OCC)OCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.406F,J-GLOBAL,CCOP(=O)(OCC)OCC,Train "EU_REACH: 6-(4-methylbenzenesulfonamido)hexanoic acid",,78521-39-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5536/7/4/2/?documentUUID=92b56796-fdb7-4e50-be01-6ce73a576bc0,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)S(=O)(=O)NCCCCCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/95822,PubChem,Cc1ccc(S(=O)(=O)NCCCCCC(=O)O)cc1,Train "JP_CHRIP: 2,2'-Azobisisobutyronitrile","JP_CHRIP: 2,2'-Azobis(2-methylpropanenitrile) 2,2'-Azobisisobutyronitrile",78-67-1,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-meti-0024e.html,"JP_CHRIP: There is a description that in the skin irritation test (OECD TG 404), as a result of a 4-hour semi-occlusive application of 500 mg of this substance to rabbits, no irritation was observed (SIDS (2002), Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)). Other than this, there is a report that no irritation was observed in a 24-hour application test with rabbits, and it is described in two reports of skin irritation tests with guinea pigs (application time is unknown) that no irritation was observed or that slight irritation was observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)). Since no irritation was observed in the test according to the test guidelines, it was classified as ""Not classified.""",Provided,JP_CHRIP,1,CC(C)(N=NC(C)(C)C#N)C#N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.955K,J-GLOBAL,CC(C)(C#N)N=NC(C)(C)C#N,Train "EU_REACH: 2-{4'-[difluoro(3,4,5-trifluorophenoxy)methyl]-3',5'-difluoro-[1,1'-biphenyl]-4-yl}-5-ethyloxane",,787582-75-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30133/7/4/2/?documentUUID=c0c81aef-3001-4edb-a95e-6502de724a6b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1CCC(OC1)C2=CC=C(C=C2)C3=CC(=C(C(=C3)F)C(OC4=CC(=C(C(=C4)F)F)F)(F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/58995748,PubChem,CCC1CCC(c2ccc(-c3cc(F)c(C(F)(F)Oc4cc(F)c(F)c(F)c4)c(F)c3)cc2)OC1,Train "JP_CHRIP: 2-Bromobutane","JP_CHRIP: 2-Bromobutane",78-76-2,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2068e.html,"JP_CHRIP: Based on a report that erythema and edema were seen after the application of this substance in a rabbit skin irritation test (OECD TG 404-compliant) and the skin primary irritation index was 2.44 (erythema 1.78, edema 0.66) (ECETOC TR 66 (1995)), it was classified as ""Not classified"" (Category 3 in UN GHS classification).",Provided,JP_CHRIP,1,CCC(C)Br,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.481H,J-GLOBAL,CCC(C)Br,Train "JP_CHRIP: Isobutylamine KR_NCIS: Isobutylamine","JP_CHRIP: 1-Amino-2-methylpropane 2-Methyl-1-propanamine 2-Methylpropylamine KR_NCIS: 1-Amino-2-methylpropane; 1-Propanamine, 2-methyl-; 2-Methyl-1-aminopropane; 2-Methyl-1-propanamine; 2-Methylpropan-1-amine; 2-Methylpropanamine; 2-Methylpropylamine; 3-Methyl-2-propylamine",78-81-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0008e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","JP_CHRIP: It was classified in Category 1 because it was judged that exposure causes irreversible damage to skin from a description as ""skin contact can result in erythema and blistering"" (PATTY (5th, 2001)), and a description as ""a powerful irritant to skin, eyes and mucous membrane"" accompanied by pain, redness, and burns to skin (HSDB (2008)). Besides, there is information that the substance is corrosive to the eyes, skin and respiratory tract as effects of short-time exposures (ICSC (J) (2005)).",,"JP_CHRIP, KR_NCIS",2,CC(C)CN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J46.573I,J-GLOBAL,CC(C)CN,Train "JP_CHRIP: Isobutyraldehyde","JP_CHRIP: 2-Methyl-1-propanal 2-Methylpropanal Isobutanal isobutylaldehyde",78-84-2,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-meti-2006e.html,"JP_CHRIP: [Rationale for the Classification] Based on (1) and (2), it was classified as ""Not classified."" Besides, because (3)-(5) are data in 1952, and the test details are unknown, and (6) is information from ICSC, these were not adopted for classification. [Evidence Data] (1) There is a report that in a skin irritation test with rabbits (OECD TG404, GLP, n=3), after 4-hour semi-occlusive application of this substance itself (purity 99% or more), erythema (score: 0.7-1.7) and edema (score: 0-0.3) were observed with recovery within 7 days (REACH registration dossier (Accessed Oct. 2018)). (2) There is a report that in a skin irritation test with rabbits (OECD TG404, GLP, n=4), in which this substance itself (purity 98%) was applied by using a patch for 4 hours, PII was is 0.13 in 72 hours (ECETOC TR66 (1995)). [Reference Data, etc.] (3) There is a report that in a skin irritation test with rabbits (n=6), after open application of this substance, significant erythema was observed in one animal (SIDS (2004)). (4) There is a description that this substance causes moderate to severe skin irritation and burns in rabbits (SIDS (2004)). (5) There is a description that this substance may be corrosive at extremely high concentrations (SIDS (2004)). (6) There is a description that this substance is corrosive to the skin, and that it causes pain, redness, blisters, and burns upon contact with the skin (Environmental Risk Assessment for Chemical Substances Vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010)).",Provided,JP_CHRIP,1,CC(C)C=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.483D,J-GLOBAL,CC(C)C=O,Train "JP_CHRIP: 2-Methyl-2-propenal KR_NCIS: 2-Methyl-2-propenal","JP_CHRIP: 2-Methyl-2-propenal Isobutenal Methacrolein",78-85-3,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0065e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","JP_CHRIP: In rabbit test (OECD TG404), 4-hour application of 0.5 mL produced moderate erythema and oedema and skin primary irritation index was 4.11. Blanching was observed from day 3 and necrosis was observed from day 9 and persisted to the end of the observation period (ECETOC TR 66 (1995)). The substance was classified into Category 1 based on a result of irreversible symptoms in the rabbit test (ECETOC TR 66 (1995)) and a report of ""strong irritant"" for humans (HSDB (2002)).",Provided,"JP_CHRIP, KR_NCIS",2,CC(=C)C=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.484B,J-GLOBAL,C=C(C)C=O,Train "JP_CHRIP: 1,2-Propanediamine NZ_CCID: 1,2-Diaminopropane","JP_CHRIP: 1,2-Diaminopropane 1,2-Propanediamine NZ_CCID: 1,2-propylenediamine",78-90-0,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0128e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6501D508-797D-4E37-8053-90046273E16F","JP_CHRIP: There are results of ""corrosive"" in a rabbit test by occluded dermal application of 500 microL for 24-hour (IUCLID (2000)) and ""corrosive"" in another rabbit test by dermal application of undiluted substance for 15 min (IUCLID (2000)). The substance is classified into C; R35 in EU classification (EU-Annex I (access on Sep. 2009)). Based on these data, the substance was classified into Category 1. NZ_CCID: Skin Irritation UN #2258 UN CLASS: 8 PG II Eye Irritation R PHRASE: R 35 [Company Data] UN #2258 UN CLASS: 8 PG II",,"JP_CHRIP, NZ_CCID",2,CC(N)CN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.225K,J-GLOBAL,CC(N)CN,Train "JP_CHRIP: 2-Butanol","JP_CHRIP: 1-Methyl propanol 2-Butanol Butylene hydrate Methyl ethyl carbinol sec-Butyl alcohol",78-92-2,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2080e.html,"JP_CHRIP: There is a report that in a skin irritation test (OECD TG 404) with rabbits, the primary irritation score was 0, and it was not irritating (SIDS (2012), ECETOC JACC (2003)), and there are descriptions that it was not irritating to the skin (EHC 65 (1987), ACGIH (2002), DFGOT vol. 19 (2003)), and that it was very slightly irritating (PATTY (6th, 2012)). From the above results, it was classified as ""Not classified.""",Provided,JP_CHRIP,1,CCC(C)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.832K,J-GLOBAL,CCC(C)O,Train "JP_CHRIP: Methyl vinyl ketone KR_NCIS: Methyl vinyl ketone NZ_CCID: Methyl vinyl ketone","JP_CHRIP: 3-Buten-2-one 3-Butene-2-one Methylene acetone KR_NCIS: 1-Buten-3-one; 2-Butenone; 3-Buten-2-one; 3-Oxo-1-butene; 3-Oxobutene; Acetyl ethylene; Butenone; Methyl vinyl ketone; Methylene acetone NZ_CCID: 1-Buten-3-one, 2-Butenone, 3-Buten-2-one, Butenone, Methylvinyl ketone, Methylvinylketone, Vinyl methyl ketone",78-94-4,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2004e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/40D0F8D4-93EA-4DF3-B988-BCCE7CE6866F","JP_CHRIP: [Rationale for the Classification] It was classified in Category 1 from (1) - (4). [Evidence Data] (1) This substance is a severe skin, eye, and respiratory tract irritant in humans and one of the more potent irritants of mucous membranes, particularly of the eye and respiratory tract (ACGIH (7th, 2001)). (2) This substance has a strong irritative effect on mucous membranes, and skin contact leads to severe necrosis (MAK (DFG) vol.9 (1998)). (3) This substance has strong irritative and corrosive effects on the skin and mucosa and causes severe eye and lung damage (GESTIS (Access on April 2020), HSDB (Access on April 2020)). (4) In a test in which this substance (0.2 mL) was applied to the rabbit skin (application time: unknown), hyperemia and edema occurred after 1 hour, edema disappeared on day 2, but deep purulent ulcers developed, and 28-30 days were required for recovery (MAK (DFG) vol.9 (1998)). NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,CC(=O)C=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J7H,J-GLOBAL,C=CC(C)=O,Train "JP_CHRIP: 2-Propanone, 1-chloro- NZ_CCID: Chloroacetone","JP_CHRIP: 1-Chloro-2-propanone Acetonyl chloride Monochloroacetone NZ_CCID: 1-Chloro-2-propanone, 1-Chloroacetone, 2-Propanone, 1-chloro-, 3-Chloro-2-propanone, Acetonyl chloride, Chloro-2-propanone, Chloromethyl methyl ketone, Chloropropanone, Monochloracetone, Monochloroacetone",78-95-5,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0699e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/78B28B2C-9C04-42F6-9710-F0EBB272887F","JP_CHRIP: Based on statements that moderate to severe erythemas and edemas were observed on the rabbit (BUA 226 (2000)) and that this product indicates skin corrosivenesses (ICSC (J) (1996)), it was classified as Category 1A-1C. NZ_CCID: Skin Irritation UN #1695 UN CLASS: 8 PG I Eye Irritation UN #1695 UN CLASS: 8 PG I",,"JP_CHRIP, NZ_CCID",2,CC(=O)CCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.487G,J-GLOBAL,CC(=O)CCl,Train "AU_HCIS: 2-Propanol, 1-amino- JP_CHRIP: 1-aminopropan-2-ol; isopropanolamine NZ_CCID: Aminopropanol","AU_HCIS: 1-aminopropan-2-ol isopropanolamine JP_CHRIP: 1-aminopropan-2-ol 2-Propanol, 1-amino- Isopropanolamine Threamine NZ_CCID: 1-Amino-2-hydroxypropane, 1-Amino-2-propanol, 1-Aminopropan-2-ol, 1-Methyl-2-aminoethanol, 2-Amino-1-methylethanol, 2-Hydroxy-1-propylamine, 2-Hydroxypropanamine, 2-Hydroxypropylamine, 2-Propanol, 1-amino, Isopropanolamine, Monoisopropanolamine, Threamine, alpha-Aminoisopropyl alcohol",78-96-6,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3674 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0072e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EB896F26-395E-4244-BFED-E1176F9F5452","JP_CHRIP: Exposure time of 15 minutes and longer to undiluted application to rabbit skin led to the development of necrosis (DFGOT (1998)), and in a DOT corrosivity test, the substance was classified as corrosive to the skin (DFGOT (1998)). Thus, it was classified into Category 1. As relevant information, the pH of its high-concentration solution (10 g/L) is 11.3 (20degC) (IUCLID (2000)), and the substance is rated R24 in EU classification. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CC(O)CN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.961E,J-GLOBAL,CC(O)CN,Train "EU_REACH: 4-(2-{4-[2-(3-cyanophenyl)ethenyl]phenyl}ethenyl)benzonitrile",,79026-02-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18823/7/4/2/?documentUUID=c6c46ec9-abee-4f2f-ad77-498d73cd9c9c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC(=C1)C#N)/C=C/C2=CC=C(C=C2)/C=C/C3=CC=C(C=C3)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/19982709,PubChem,N#Cc1ccc(/C=C/c2ccc(/C=C/c3cccc(C#N)c3)cc2)cc1,Train "NZ_CCID: Propionyl chloride US_HSDB: Propionyl chloride",,79-03-8,Cat 1,"NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F1182FB1-AE66-44B5-A2C3-A4A429138564 US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8374","NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"NZ_CCID, US_HSDB",2,CCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/62324,PubChem,CCC(=O)Cl,Train "JP_CHRIP: Chloroacetyl chloride KR_NCIS: Chloroacetyl chloride NZ_CCID: Chloroacetyl chloride US_HSDB: Chloroacetyl chloride","JP_CHRIP: 2-chloroacetyl chloride Chloroacetic acid chloride Chloroacetyl chloride Monochloroacetyl chloride KR_NCIS: 2-Chloroacetyl chloride; Acetyl chloride, 2-chloro-; Acetyl chloride, chloro-; Chloroacetic Acid chloride; Chloroacetic chloride; Monochloroacetyl chloride NZ_CCID: Acetyl chloride, chloro-, Chloracetyl chloride, Chloroacetic acid chloride, Chloroacetic chloride, Monochloroacetyl chloride",79-04-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2037e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/304FEE4E-B4E4-48B6-A12A-480E0768125F US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/973","JP_CHRIP: Based on a report that it was corrosive when the undiluted liquid of this substance was applied to rabbits for 24 hours (HSDB (Access on June 2014)), and on a description that this substance was corrosive to the skin (ACGIH (7th, 2001), Environmental Risk Assessment for Chemical Substances Vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010)), it was judged as Category 1. Besides, this substance was classified as ""C; R35"" in the EU DSD classification, and as ""H314 Skin Corr. 1A"" in the EU CLP classification. The category was changed by adding information. NZ_CCID: Skin Irritation R PHRASE: R 35 [Company Data] UN #1752 UN CLASS: 8 PG I Eye Irritation R PHRASE: R 35 [Company Data] UN #1752 UN CLASS: 8 PG I",,"JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",4,ClCC(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.490G,J-GLOBAL,O=C(Cl)CCl,Train "JP_CHRIP: Bromoacetic acid NZ_CCID: Bromoacetic acid US_HSDB: Bromoacetic acid","JP_CHRIP: Bromoacetic acid NZ_CCID: Acetic acid, bromo-",79-08-3,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0027e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/21A01F8E-6D73-49DC-9FF1-77A9F4B830AF US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/7627","JP_CHRIP: Based on a report of ""Skin contact causes severe burns"" (HSDB (2009)) and classification as R35 in EU classification (EU-Annex I (2009)), the substance was classified into Category 1. NZ_CCID: Skin Irritation REMARK: UN1938 class 8: PGII Eye Irritation EXPERT JUDGEMENT: Classified 8.3A on the basis of the 8.2B Skin Irritation classification.",,"JP_CHRIP, NZ_CCID, US_HSDB",3,OC(=O)CBr,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.492C,J-GLOBAL,O=C(O)CBr,Train "AU_HCIS: propionic acid … % JP_CHRIP: Propionic acid NZ_CCID: Propionic acid","JP_CHRIP: Ethanecarboxylic acid Ethylformic acid Methylacetic acid Propanoic acid NZ_CCID: Carboxyethane, Ethanecarboxylic acid, Ethylformic acid, Luprosil, Metacetonic acid, Methyl acetic acid, Methylacetic acid, Monoprop, Propanoic acid, Prozoin, Pseudoacetic acid",79-09-4,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3694 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2083e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/790EA423-1E34-4175-A6F2-661589F53EAA","JP_CHRIP: Since after application of 0.5 mL of the undiluted liquid of this substance to guinea pigs, mild to moderate edema, moderate to severe erythema and necrosis were observed at 2 hours after application, and necrosis was observed after 24 and 48 hours, it is considered to be corrosive (SIDS (2008)). In addition, there is a report that necrosis was observed after non-occlusive application of 0.01 mL of the undiluted liquid of this substance to rabbits for 24 hours (SIDS (2008), ACGIH (7th, 2001), PATTY (6th, 2012)). From the above results, it was classified in Category 1. Besides, this substance was classified as ""C; R34"" in the EU DSD classification, and as ""Skin Corr. 1B H314"" in the EU CLP classification. NZ_CCID: Skin Irritation SPECIES: Rabbit RESULT: Irritating REFERENCE SOURCE: BASF AG Ludwigshafen(86)(86) Loden M. et al.: FOA Rept E40023, Natl. Environ. Protect. Board, Sweden, (1985), zitiert in Bibra (1991) [IUCLID 2000] REMARK: Mild Skin Irritation was seen following 4 h closed contact of the skin with a 2.5 % aqueous solution, mild to moderate irritation occurred with 25 % solutions, while moderate to severe irritation and corrosion were seen at concentrations of 40 % and above. Eye Irritation SPECIES: Rabbit RESULT: Corrosive REFERENCE SOURCE: Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986. 767 **PEER REVIEWED** [HSDB]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CCC(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.963A,J-GLOBAL,CCC(=O)O,Train "AU_HCIS: acrylic acid EU_REACH: prop-2-enoic acid JP_CHRIP: Acrylic acid KR_NCIS: 2-Propenoic acid; Acrylic acid NZ_CCID: Acrylic acid US_HSDB: Acrylic acid","AU_HCIS: prop-2-enoic acid 2-Propenoic acid acroleic acid glacial acrylic acid ethylenecarboxylic acid JP_CHRIP: 2-Propenoic acid Acroleic acid Ethylenecarboxylic acid NZ_CCID: 2-Propenoic acid, Acroleic acid, Ethylenecarboxylic acid, Propenoic acid, Vinylformic acid",79-10-7,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=93 EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15803/7/4/2/?documentUUID=a3ed58c4-466a-4606-8160-ab9d148aa4bf JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2001e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7F31379C-2C49-40F3-91B3-1606459E1E24 US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1421","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: There is a report that in a skin irritation test (OECD TG compliant) in which the undiluted liquid of this substance was applied semi-occlusively to rabbits for 3 minutes, superficial necrosis, slight edema, and discoloration were observed, and on histopathological examination, deep focal necrosis and loss of epidermal adnexa in the necrosis area, and perifocal moderate epithelial hyperplasia and diffuse inflammatory reaction were observed in the application area (EU-RAR (2002)). In addition, there is a report that as a result of a 1-minute application of the undiluted liquid of this substance to rabbits, a corrosive reaction was observed (EU-RAR (2002), ECETOC JACC (1995)). Moreover, in humans, 2 workers needed hospitalisation because of skin corrosion during 1967-1992 (EU-RAR (2002)). Based on the above results, it was classified in Category 1A. Besides, it was classified as ""C, R35"" in the EU DSD classification, and ""Skin Corr. 1A, H314"" in the EU CLP classification. NZ_CCID: Skin Irritation R- PHRASE: R 35 Causes severe burns. [ec classification] Eye Irritation SPECIES: Rabbit RESULT: Concentrated ""glacial"" acrylic acid...caused injury graded 9 on a scale with the maximum of 10 (10 being the most severe). REFERENCE SOURCE: Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986. 51. [hsdb]",Provided,"AU_HCIS, EU_REACH, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",6,OC(=O)C=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.493A,J-GLOBAL,C=CC(=O)O,Train "AU_HCIS: chloroacetic acid JP_CHRIP: Chloroacetic acid [monochloroacetic acid] KR_NCIS: Chloroacetic acid NZ_CCID: Chloroacetic acid US_HSDB: Chloroacetic acid","JP_CHRIP: Chloroethanoic acid MCA Monochloroacetic acid KR_NCIS: Chloracetic acid; alpha-Chloroacetic acid; Chloroethanoic acid; MCA; MCAA; MKhUK; Monochloroacetic acid; Monochloroethanoic acid; Acetic acid, chloro- NZ_CCID: Acetic acid, chloro-, Chloracetic acid, Chloroethanoic acid, Monochloracetic acid, Monochloroacetic acid, Monochloroethanoic acid",79-11-8,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=911 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0051e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9160B2E8-2CA2-496B-9884-80C5FA0A321D US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/939","JP_CHRIP: This substance is strongly acidic (pH <1 at 800g/L, 20 degrees C, GESTIS (Access on July 2015)). It is reported that in a skin irritation test using rabbits that 2 animals died after 24-hour occlusive application with 500 mg, and severe erythema and edema were observed, and a primary dermal irritation index was 7.66 (maximum 8) (ECETOC JACC 38 (1999)), and it is reported that after 0.5 mL of a 75% solution of this substance was applied, necrosis was observed after 30 seconds (SIDS (2009)). Besides these, corrosion is reported in an application of this substance in a test using rats or mice (EU-RAR (2005); Initial Risk Assessment, NITE (2008)). Moreover, in multiple accidental contacts in humans, it is reported that chemical burns occurred (EU-RAR (2005); Initial Risk Assessment, NITE (2008)). From the above, because necrosis was observed 30 seconds after application in rabbits, the substance was classified in Category 1A. Besides, it is classified in ""Skin. Corr. 1B H314"" in EU CLP classification (ECHA CL inventory (Access on September 2015)). NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,OC(=O)CCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.409K,J-GLOBAL,O=C(O)CCl,Train "JP_CHRIP: Hydroxyacetic acid NZ_CCID: Glycolic acid US_HSDB: HYDROXYACETIC ACID","JP_CHRIP: Acetic acid, hydroxy- Alpha-hydroxyacetic acid Glycolic acid hydroxyacetic acid Hydroxyethanoic acid",79-14-1,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0051e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/08614520-C000-418C-8BBA-8D63504D958E US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/5227","JP_CHRIP: In skin irritation tests with rabbits on this substance of purity 99% (cosmetic grade) and a 70% aqueous solution of this substance (technical grade) (tests according to OECD TG404 or similar protocols, GLP-compliant), visible necrosis through the epidermis and into the dermis was observed after a 1-hour application, and it was judged as corrosive (NICNAS (2000)). Therefore, it was classified in Category 1B. Besides, the pH of a 70% aqueous solution of this substance was < 0.5 (NICNAS (2000)). NZ_CCID: Skin Irritation REMARK: Solutions containing 30%, 50% and 70% cosmetic grade glycolic acid at their natural pH and a 70% solution adjusted to pH 3 were assigned to Packing Group II (moderate corrosives). REFERENCE SOURCE: [NICNAS Priority Existing Chemical Assessment Report No. 12] Eye Irritation SPECIES: Rabbit RESULT: A solution containing 64% glycolic acid (pH not reported) caused severe, irreversible effects including total blindness and was classified as corrosive. REFERENCE SOURCE: (DuPont, 1977). [NICNAS Priority Existing Chemical Assessment Report No. 12]",Provided,"JP_CHRIP, NZ_CCID, US_HSDB",3,OCC(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.494J,J-GLOBAL,O=C(O)CO,Train "EU_REACH: N-methylacetamide",,79-16-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26228/7/4/2/?documentUUID=4f8331e4-3ec2-4692-b8d8-6d8e471fd4ba,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)NC,https://pubchem.ncbi.nlm.nih.gov/compound/6582,PubChem,CNC(C)=O,Train "AU_HCIS: peracetic acid . . . % JP_CHRIP: Peroxyacetic acid","AU_HCIS: peroxyacetic acid acetic peroxide acetyl hydroperoxide estosteril JP_CHRIP: Acetyl hydroperoxide Ethaneperoxoic acid",79-21-0,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3414 JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2032.html","JP_CHRIP: 【分類根拠】 （１）～（３）より、区分1Aとした。なお、新たな知見に基づき、分類結果を変更した。 【根拠データ】 （１）本物質0.013％～0.34％溶液は非刺激性～軽度の刺激性物質であるが、3.4％以上の濃度で45分間以上適用した場合、ウサギの皮膚に腐食性影響を示した。5％溶液を3分間適用した場合は中程度～重度の刺激性がみられ、10％～40％溶液では3分以内に腐食性影響を示した（SIAR (2008)、AICIS IMAP (2013)）。 （２）ウサギを用いた皮膚刺激性試験（3分間適用、本物質10％溶液）において、腐食性影響がみられたとの報告がある（SIAR (2008)、AICIS IMAP (2013)）。 （３）ウサギを用いた皮膚刺激性試験（3分間適用、本物質15％溶液）において、腐食性影響がみられたとの報告がある（SIAR (2008)、AICIS IMAP (2013)）。",,"AU_HCIS, JP_CHRIP",2,CC(=O)OO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.833I,J-GLOBAL,CC(=O)OO,Train "JP_CHRIP: methyl chloroformate NZ_CCID: Methyl chloroformate","JP_CHRIP: Carbonochloridic acid, methyl ester chloroformic acid methyl ester Methoxycarbonyl chloride Methyl chlorocarbonate",79-22-1,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0008e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/61ECBDB5-56E6-404E-956B-B219B79EC6DD","JP_CHRIP: The substance was classified into Category 1 since the substance caused damage to skin, and its contact to eyes and skin was highly irritating or corrosive in guinea pig studies (PATTY (5th 2001)). Similarly, the substance is reported to be a highly corrosive irritant according to HSDB (2002); and it is rated R34 in EU classification. NZ_CCID: Skin Irritation UN CLASS: 8, PG I. Eye Irritation UN CLASS: 8, PG I.",,"JP_CHRIP, NZ_CCID",2,COC(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.836I,J-GLOBAL,COC(=O)Cl,Train "NZ_CCID: Isobutyryl chloride",,79-30-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/02A72A25-6955-4F07-8B2E-D35D8101D981,"NZ_CCID: Skin Irritation UN #2353 UN CLASS: 8; PG II Eye Irritation R PHRASE: R 35 [Company Data] UN #2353 UN CLASS: 8 PG II",,NZ_CCID,1,CC(C)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/62325,PubChem,CC(C)C(=O)Cl,Train "EU_REACH: 2-methylpropanoic acid JP_CHRIP: 2-Methylpropionic acid NZ_CCID: Propanoic acid, 2-methyl-","JP_CHRIP: 2-Methylpropanoic acid Dimethylacetic acid Propionic acid, 2-methyl- NZ_CCID: 2-Methylpropanoic acid, 2-Methylpropionic acid, Dimethylacetic acid, I-Butyric acid, Isobutanoic acid, Isobutyric acid, Isopropylformic acid, iso-Butyric acid",79-31-2,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14591/7/4/2/?documentUUID=a09fc7c1-3520-4e26-9032-37c607c255e0 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0073e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F35B0457-9AFA-49DB-9A94-8B4CE7090AA0","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: Based on a result of ""caused some necrosis within 24-hour"" in skin irritation test (open) with rabbits (PATTY (5th, 2001)) and a report of corrosive in rabbit test (IUCLID (2000)), the substance was classified into Category 1. NZ_CCID: Skin Irritation SPECIES: Rabbit RESULT: Corrosive REFERENCE SOURCE: BASF AG Ludwigshafen Hoechst AG Frankfurt/Main (29) BASF AG; Abteilung Toxikologie; Unveroeffentlichte Untersuchung (XXIII/273), 19.04.74 [iuclid 2000} Eye Irritation SPECIES: Rabbit RESULT: Rated 9 on a scale of 1-10, paying particular attention to condition of cornea, most severe injuries rated 10. REFERENCE SOURCE: [Peer Reviewed] [Grant, W. M. Toxicology of the Eye. 2nd ed. Springfield, Illinois: Charles C. Thomas, 1974. 1166] [HSDB]",Provided,"EU_REACH, JP_CHRIP, NZ_CCID",3,CC(C)C(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.840G,J-GLOBAL,CC(C)C(=O)O,Train "EU_REACH: (2S)-2-hydroxypropanoic acid JP_CHRIP: L-Lactic acid NZ_CCID: (S)-2-Hydroxypropanoic acid","JP_CHRIP: (S)-2-Hydroxypropionic acid DL-lactic acid L-Lactic acid",79-33-4,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14252/7/4/2/?documentUUID=c84f268b-9269-4502-b486-f5ed9ee9b3ad JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0140e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A33371AB-A87C-4F02-8041-F4FA667EAEB9","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: Since a dermal irritation test (OECD TG 404) using rabbits with this substance indicated severe irritation, and it was corrosive (SIAP (2011)), it was classified in Category 1. NZ_CCID: Skin Irritation SPECIES: rabbit RESULT: corrosive RELIABILITY (KLIMISCH SCORE): 1 (OECD 404, GLP, 1983 and 1986) Eye Irritation SPECIES: chicken eye (the Enucleated Eye Test with chicken eyes (CEET)) RESULT: Cornea score: 3 (mean; 180 and 240 minutes) (max. 4) Remarks: corneal swelling could not be measured at 30, 75 and 120 minutes time interval due to severe to complete corneal opacity Opacity: 4 (mean; 30, 75, 120, 180, 240 minutes) (max. 4) Fluorescein: 4 (mean; 30 minutes) (max. 4) Remarks: Fluorescein retention was only scored at 30 minutes after treatment RELIABILITY (KLIMISCH SCORE): 2 (according to guideline, 1996, GLP)",Provided,"EU_REACH, JP_CHRIP, NZ_CCID",3,C[C@H](O)C(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J9.134K,J-GLOBAL,C[C@H](O)C(=O)O,Train "JP_CHRIP: dichloroacetyl chloride NZ_CCID: Dichloroacetyl chloride","JP_CHRIP: Dichloroacetyl chloride",79-36-7,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0073e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/31A12432-753D-41E2-89CE-B6E878A14A69","JP_CHRIP: It has been documented that in an irritation test using rabbits in which 2 mg of the substance was applied to the skin for 24 hours, the substance was severely irritating (RTECS (2007)). Also, in cases of humans, it has been documented to be a strong irritant to skin and eyes (HSDB (2003)). Thus, the substance was classified into Category 1. NZ_CCID: Skin Irritation UN # 765 UN CLASS: 8 PG II Eye Irritation R PHRASE: R 35 [Company Data] UN # 765 UN CLASS: 8 PG II",,"JP_CHRIP, NZ_CCID",2,ClC(Cl)C(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.841E,J-GLOBAL,O=C(Cl)C(Cl)Cl,Train "NZ_CCID: Oxalyl chloride",,79-37-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9B6BA50A-3539-4AC1-9EB6-24FC5DD1EE8E,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(=O)(C(=O)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/65578,PubChem,O=C(Cl)C(=O)Cl,Train "JP_CHRIP: Methacrylamide","JP_CHRIP: 2-Methylprop-2-enamide",79-39-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0071e.html,"JP_CHRIP: There were two test data in conformity with OECD TG 404 and GLP. In the first test, slight erythema in all 3 rabbits was reported after patch removal, but symptoms were reversible after 24 hours. The primary irritation index score was 0.0 and resulted as ""not irritating"" (SIDS (Access on Jul. 2010)). In the second study, slight to well defined erythema was noted in all 3 rabbits after patch removal, and very slight edema was noted in 1 animal. These symptoms recovered within 7 days. The primary irritation index score was 1.11 and resulted as ""slightly irritating"" (SIDS (Access on Jul. 2010)). Based on the information, the substance was classified as ""Not classified"".",Provided,JP_CHRIP,1,CC(=C)C(=O)N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J38.885H,J-GLOBAL,C=C(C)C(N)=O,Train "AU_HCIS: methacrylic acid JP_CHRIP: Methacrylic acid NZ_CCID: 2-Propenoic acid, 2-methyl- (stabilised), (methacrylic acid)","AU_HCIS: 2-methylpropenoic acid 2-Propenoic acid, 2-methyl- JP_CHRIP: 2-Methylpropenoic acid 2-Prop-2-enoic acid alpha-Methylacrylic acid NZ_CCID: 2-Methyl-2-propenoic acid, 2-Methylacrylic acid, 2-Methylpropenoic acid, 2-Propenoic acid, 2-methyl-, Methacrylic Acid, alpha-Methylacrylic acid",79-41-4,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=2842 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2035e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/21EA3B75-4390-4764-85E5-6C6D9907EFD5","JP_CHRIP: There is a report that in a skin irritation test with rabbits (compliant with Confirmation test in the US Department of Transportation Packing Group classification), corrosivity was observed on observation immediately after a test in which undiluted liquid of this substance was openly applied for 3 minutes, followed by wiping away with a water-impregnated paper towel (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)). Therefore, this substance was classified in Category 1A based on the criteria of sub-categories. Besides, this substance is classified as ""Skin Corr. 1A"" in EU CLP classification (ECHA CL Inventory (Access on June 2017)). NZ_CCID: Skin Irritation SPECIES: Rabbit RESULT: Highly corrosive REFERENCE SOURCE: Degussa AG Frankfurt am Main (148) Rohm & Haas, unpublished report, Skin Irritation study in rabbits, Report No. 96R-132, 1996.* [IUCLID 2000] REMARK: EC Classification: Highly corrosive (causes severe burns). Eye Irritation SPECIES: Rabbit RESULT: Corrosive REFERENCE SOURCE: Source: Degussa AG Frankfurt am Main (145) Elf Atochem: Acide Methacrylique (AMA) irritation studies in the rabbit. Consultox Laboratories Limited, report no. CL80:62:2027 (1980). [IUCLID 2000] REMARK: EC Classification: Risk of serious damage to eyes.",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CC(=C)C(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.843A,J-GLOBAL,C=C(C)C(=O)O,Train "NZ_CCID: 2-Mercaptopropionic acid","NZ_CCID: thiolactic acid",79-42-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B232771A-FBBA-499E-AC11-11F62679AF5C,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C(=O)O)S,https://pubchem.ncbi.nlm.nih.gov/compound/62326,PubChem,CC(S)C(=O)O,Train "JP_CHRIP: Dichloroacetic acid KR_NCIS: Dichloroacetic acid ; DCA NZ_CCID: Dichloroacetic acid US_HSDB: Dichloroacetic acid","JP_CHRIP: 2,2-Dichloroacetic acid Bichloroacetic acid DCA Dichlorethanoic acid KR_NCIS: DCA",79-43-6,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0043e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5CB9355F-A549-41F6-9539-363700D75AB5 US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/6894","JP_CHRIP: It is written that irritation was observed after the application of 10 mg this substance in rabbits (ACGIH (7th, 2005)) and that severe irritation was found after the 24-hour application of 2 mg this substance (ACGIH (7th, 2005)). Moreover, it is not specific information, but it is written that this substance is corrosive to the skin (Result of the initial environmental risk assessment of chemicals, Vol. 5, Ministry of the Environment in Japan, Tentative hazard assessment sheet (2006); GESTIS (Access on July 2015)). Furthermore, this substance is classified in ""Skin. Corr. 1A H314"" in EU CLP classification (ECHA CL inventory (Access on September 2015)). From the above, it was classified in Category 1. NZ_CCID: Skin Irritation UN #1764 UN CLASS: 8; PG II Eye Irritation R PHRASE: R 35 [Company Data]",,"JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",4,OC(=O)C(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.834G,J-GLOBAL,O=C(O)C(Cl)Cl,Train "EU_REACH: (±)-dihydro-3-hydroxy-4,4-dimethylfuran-2(3H)-one",,79-50-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16642/7/4/2/?documentUUID=81b9200f-89a9-4c5e-b6fb-6ba65fd0033b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(COC(=O)C1O)C,https://pubchem.ncbi.nlm.nih.gov/compound/989,PubChem,CC1(C)COC(=O)C1O,Train "NZ_CCID: Pempidine",,79-55-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/154D9707-676F-4E30-9873-F340AD3656A9,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CC1(CCCC(N1C)(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6603,PubChem,CN1C(C)(C)CCCC1(C)C,Train "EU_REACH: 2-Naphthalenecarboxamide, N,N'-(2,5-dimethyl-1,4-phenylene)bis[4-[2-(5-chloro-2-methylphenyl)diazenyl]-3-hydroxy-",,79665-24-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10328/7/4/2/?documentUUID=9f9c4352-bd09-478d-bb5e-effb60cf28af,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)Cl)N=NC2=C(C(=CC3=CC=CC=C32)C(=O)NC4=CC(=C(C=C4C)NC(=O)C5=CC6=CC=CC=C6C(=C5O)N=NC7=C(C=CC(=C7)Cl)C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/174176,PubChem,Cc1ccc(Cl)cc1N=Nc1c(O)c(C(=O)Nc2cc(C)c(NC(=O)c3cc4ccccc4c(N=Nc4cc(Cl)ccc4C)c3O)cc2C)cc2ccccc12,Train "KR_NCIS: 3-Dodecyl-1-(2,2,6,6-tetramethyl-4-piperidinyl)-2,5-pyrrolidinedione","KR_NCIS: 2,5-Pyrrolidinedione, 3-dodecyl-1-(2,2,6,6-tetramethyl-4-piperidinyl)-; 2-Dodecyl-N-(2,2,6,6-tetramethyl-4-piperidinyl)succinimide; 3-Dodecy-1-(2,2,6,6-tetramethyl-4-piperidinyl)-2,5-pyrrolidinedione; 3-Dodecyl-1-(2,2,6,6-tetramethyl-4-piperidinyl)-2,5-pyrrolidinedione; 3-Dodecyl-1-(2,2,6,6-tetramethylpiperidin-4-yl)pyrrolidine-2,5-dione; 3-Dodecyl-N-(2,2,6,6-tetramethyl-4-piperidinyl)succinimide; N-(2,2,6,6-Tetramethyl-4-piperidyl)-n-dodecylsuccinimide; SUCCINIMIDE, DODECYL-N-(2,2,6,6-TETRAMETHYL-4-PIPERIDINYL)-",79720-19-7,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCCCCCCCCCCCC1CC(=O)N(C1=O)C2CC(NC(C2)(C)C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/174179,PubChem,CCCCCCCCCCCCC1CC(=O)N(C2CC(C)(C)NC(C)(C)C2)C1=O,Train "JP_CHRIP: Camphene (mixed optical isomers)","JP_CHRIP: 2,2-Dimethyl-3-methylene-norborane 2,2-Dimethyl-3-methylenebicyclo(2.2.1)heptane Bicyclo(2.2.1)heptane, 2,2-dimethyl-3-methylene Bicyclo[2.2.1]heptane, 2,2-dimethyl-3-methylene- Camphene",79-92-5,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0029e.html,"JP_CHRIP: It was classified as ""Not classified"" because it was judged as no irritation in a test by a 4-hour application to the rabbit skin (OECD TG404, GLP) (SIDS (Access on June 2012)). Besides, it is reported that it was slightly irritating after a 24-hour occlusive application of undiluted this substance to the rabbit skin (HSDB (2004)), and in humans, it is reported that 4% of this substance in petrolatum produced no irritation after a 48-hour occlusive application (PATTY (5th, 2001)).",Provided,JP_CHRIP,1,CC1(C)C2CCC(C2)C1=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J39.020H,J-GLOBAL,C=C1C2CCC(C2)C1(C)C,Train "EU_REACH: 2,4-diazatetracyclo[12.4.0.0²,⁶.0⁷,¹²]octadeca-1(18),3,7,9,11,14,16-heptaen-3-amine",,80012-43-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25792/7/4/2/?documentUUID=d0ac4fe9-387a-4fbb-9ea5-a1289b3a52e5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C2C3=CC=CC=C3CC4=CC=CC=C4N2C(=N1)N,https://pubchem.ncbi.nlm.nih.gov/compound/3241,PubChem,NC1=NCC2c3ccccc3Cc3ccccc3N12,Train "EU_REACH: 4,4'-isopropylidenedicyclohexanol",,80-04-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11451/7/4/2/?documentUUID=83a740e6-3d62-4227-b746-069d620c6c67,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C1CCC(CC1)O)C2CCC(CC2)O,https://pubchem.ncbi.nlm.nih.gov/compound/94932,PubChem,CC(C)(C1CCC(O)CC1)C1CCC(O)CC1,Train "JP_CHRIP: Bisphenol A","JP_CHRIP: 2,2-bis(4-hydroxyphenyl)propane 4,4'-(1-Methylethylidene)bisphenol 4,4'-isopropylidenediphenol Bisphenol A 4,4'-(Propane-2,2-diyl)diphenol",80-05-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0123e.html,"JP_CHRIP: Because in the result of a skin irritation test using rabbits (4-hour application, OECD TG 404), skin irritation was not observed (DFGOT suppl (2011), EU-RAR (2010)), it was classified as ""Not classified.""",Provided,JP_CHRIP,1,CC(C)(c1ccc(O)cc1)c1ccc(O)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.531I,J-GLOBAL,CC(C)(c1ccc(O)cc1)c1ccc(O)cc1,Train "JP_CHRIP: Dichlorodiphenylsilane NZ_CCID: Diphenyldichlorosilane","JP_CHRIP: Dichlorodiphenylsilane",80-10-4,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0052e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DE98D35C-F618-47D0-83BE-F9D203A38109","JP_CHRIP: It is described that this substance is a corrosive chemical, contact with skin can cause severe burns leading to permanent damage, and after dermal exposure, dermatitis (red, inflamed skin), severe burns, pain, and shock occur (HSDB (2010)). And it is described that an application of chlorosilanes to rabbits caused necrosis, blistering, and sloughing on the skin (HSDB (2010)). Because the above knowledge means that irreversible damage occurs on the skin on contact with this substance, it was classified in Category 1. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,Cl[Si](Cl)(c1ccccc1)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J54.323C,J-GLOBAL,Cl[Si](Cl)(c1ccccc1)c1ccccc1,Train "AU_HCIS: α,α-dimethylbenzyl hydroperoxide JP_CHRIP: 1-Methyl-1-phenylethyl hydroperoxide NZ_CCID: Hydroperoxide, 1-methyl-1-phenylethyl 90-98%, cumene 2-10%","AU_HCIS: cumene hydroperoxide Hydroperoxide, 1-methyl-1-phenylethyl JP_CHRIP: 2-Hydroperoxy-2-phenylpropane 1-methyl-1-phenylethyl hydroperoxide 2-Phenylpropan-2-yl hydroperoxide alpha,alpha-Dimethylbenzyl hydroperoxide cumene hydroperoxide Cumyl hydroperoxide Hydroperoxide, 1-methyl-1-phenylethyl NZ_CCID: Cumene hydroperoxide, Cumyl hydroperoxide",80-15-9,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4748 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2060e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8046C3B7-4928-4A17-89BA-C7E54D1BC850","JP_CHRIP: As for skin sensitization tests with rabbits, there is a report that severe irritation and damages were found (DFGOT Vol. 3 (1992)), and a description that severe irritation or corrosivity were observed (PATTY (6th, 2012)), therefore, it was classified in Category 1. Besides, this substance was classified as ""Skin Corr. 1B"" in EU CLP classification (ECHA CL Inventory (Access on June 2017)). NZ_CCID: Skin Irritation SPECIES: Rabbit RESULT: Corrosive REFERENCE SOURCE: Clayton, G.D., F.E. Clayton (eds.) Pattys Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994. 584 **PEER REVIEWED** [HSDB] Eye Irritation SPECIES: Rabbit RESULT: Corrosive REFERENCE SOURCE: Grant, W. M. Toxicology of the Eye. 2nd ed. Springfield, Illinois: Charles C. Thomas, 1974. 332 **PEER REVIEWED** [HSDB]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CC(C)(OO)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.835E,J-GLOBAL,CC(C)(OO)c1ccccc1,Train "JP_CHRIP: 4-tert-Pentylphenol",,80-46-6,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-0029e.html,"JP_CHRIP: Based on descriptions that this substance was corrosive to the skin (EPA Pesticide (2005)), and that this substance was an irritant of Category I (HSDB (Access on August 2017)), it was classified in Category 1.",,JP_CHRIP,1,CCC(C)(C)c1ccc(O)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.250A,J-GLOBAL,CCC(C)(C)c1ccc(O)cc1,Train "EU_REACH: 5-methyl-2-(1-methylbutyl)-5-propyl-1,3-dioxane",,80480-24-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22456/7/4/2/?documentUUID=c8c446cf-9483-4031-b80c-1a4e54914855,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC(C)C1OCC(CO1)(C)CCC,https://pubchem.ncbi.nlm.nih.gov/compound/166523,PubChem,CCCC(C)C1OCC(C)(CCC)CO1,Train "EU_REACH: Resin acids and rosin acids, ester with glycerol",,8050-31-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15312/7/4/2/?documentUUID=61a6c1d6-7bea-44e2-8d21-71036db88b2e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C1=CC2=CC[C@@H]3[C@@]([C@H]2CC1)(CCC[C@@]3(C)C(=O)OCC(CO)O)C,https://pubchem.ncbi.nlm.nih.gov/compound/11852355,PubChem,CC(C)C1=CC2=CC[C@@H]3[C@](C)(CCC[C@@]3(C)C(=O)OCC(O)CO)[C@H]2CC1,Train "NZ_CCID: 2-Bromobutyric acid",,80-58-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9F54251B-45DA-4F47-9D00-6BBA0713F35D,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCC(C(=O)O)Br,https://pubchem.ncbi.nlm.nih.gov/compound/6655,PubChem,CCC(Br)C(=O)O,Train "EU_REACH: 2-[(1E)-2-(2-methoxy-5-nitrophenyl)diazen-1-yl]-N-(2-methoxyphenyl)-3-oxobutanamide",,80675-49-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10476/7/4/2/?documentUUID=b30f5356-3971-4b08-a577-db20240f2d20,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC=CC=C1OC)N=NC2=C(C=CC(=C2)[N+](=O)[O-])OC,https://pubchem.ncbi.nlm.nih.gov/compound/102295954,PubChem,COc1ccc([N+](=O)[O-])cc1N=NC(C(C)=O)C(=O)Nc1ccccc1OC,Train "NZ_CCID: 1,1,3,3-tetramethylguanidine","NZ_CCID: Guanidine, N,N,N',N'-tetramethyl-",80-70-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E1104A4D-A044-4A1C-848A-A6DE4F85F13E,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CN(C)C(=N)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/66460,PubChem,CN(C)C(=N)N(C)C,Train "EU_REACH: 1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluorooctane",,80793-17-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7612/7/4/2/?documentUUID=2cb7251a-0fc2-4c16-88aa-6ed513375f1a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/2776163,PubChem,CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train "EU_REACH: 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide",,81-13-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14227/7/4/2/?documentUUID=55f4d317-ac75-44ca-839b-a685c2fed021,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(CO)[C@H](C(=O)NCCCO)O,https://pubchem.ncbi.nlm.nih.gov/compound/131204,PubChem,CC(C)(CO)[C@@H](O)C(=O)NCCCO,Train "EU_REACH: 1,3-dichloro-2-(dichloromethyl)benzene",,81-19-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12005/7/4/2/?documentUUID=3248af29-9962-4b0a-808e-17c3ae27591a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C(=C1)Cl)C(Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/6671,PubChem,Clc1cccc(Cl)c1C(Cl)Cl,Train "EU_REACH: methyl dihydrogen phosphate",,812-00-0,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24818/7/4/2/?documentUUID=bcba15ef-7482-4eb6-afb0-9ae8209b0d91,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COP(=O)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/13130,PubChem,COP(=O)(O)O,Train "EU_REACH: 2-[4-methyl-5-oxo-4-(propan-2-yl)-4,5-dihydro-1H-imidazol-2-yl]pyridine-3-carboxylic acid JP_CHRIP: (RS)-2-(4-Isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid (synonym: imazapyr)",,81334-34-1,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21966/7/4/2/?documentUUID=17d6089d-d9d5-4e7f-8149-61bfa83ad3aa JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-0025.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: 【分類根拠】 （１）、（２）より、区分に該当しない。 【根拠データ】 （１）ウサギ（n=3）を用いた皮膚刺激性試験（OECD TG 404、GLP、半閉塞、4時間適用、72時間観察）において、皮膚刺激性はみられなかった（紅斑・痂皮スコア：0/0/0、浮腫スコア：0/0/0）との報告がある（REACH登録情報 (Accessed May 2021)）。 （２）ウサギ（n=6）を用いた皮膚刺激性試験（72時間観察）において、本物質を有傷皮膚、無傷皮膚に適用したところ、有傷皮膚では24時間後に紅斑がみられたが、72時間以内に回復した。無傷皮膚では24、72時間後に皮膚刺激性反応はみられなかったとの報告がある（食安委 農薬評価書 (2020)、EFSA (2014)、JMPR (2013)、農薬抄録 (2016)）。",Provided,"EU_REACH, JP_CHRIP",2,CC(C)C1(C)N=C(NC1=O)c1ncccc1C(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J43.085D,J-GLOBAL,CC(C)C1(C)N=C(c2ncccc2C(=O)O)NC1=O,Train "NZ_CCID: Phosphine oxide, tributyl-",,814-29-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/444CA1FD-703C-430C-AB90-D3B753F8B0A1,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCCCP(=O)(CCCC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/13138,PubChem,CCCCP(=O)(CCCC)CCCC,Train "NZ_CCID: Acryloyl chloride US_HSDB: Acrylyl chloride",,814-68-6,Cat 1,"NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/927AF785-FB58-45D9-B434-B1E15A9469C4 US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/6330","NZ_CCID: Skin Irritation R PHRASE: R 35 [Company Data] Eye Irritation R PHRASE: R 35 [Company Data]",,"NZ_CCID, US_HSDB",2,C=CC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/13140,PubChem,C=CC(=O)Cl,Train "EU_REACH: 4-({5-cyano-4-methyl-6-[(4-sulfophenyl)amino]pyridin-2-yl}amino)benzene-1-sulfonic acid",,815676-09-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22281/7/4/2/?documentUUID=c8349557-747d-4810-bec6-ebb41fb62477,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=NC(=C1C#N)NC2=CC=C(C=C2)S(=O)(=O)O)NC3=CC=C(C=C3)S(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/11167833,PubChem,Cc1cc(Nc2ccc(S(=O)(=O)O)cc2)nc(Nc2ccc(S(=O)(=O)O)cc2)c1C#N,Train "EU_REACH: (2S,4S)-4-(phenylsulfanyl)pyrrolidine-2-carboxylic acid",,81653-77-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1157/7/4/2/?documentUUID=b46de39b-cf30-4686-8289-615dfa0648dc,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1[C@@H](CN[C@@H]1C(=O)O)SC2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/11379084,PubChem,O=C(O)[C@@H]1C[C@H](Sc2ccccc2)CN1,Train "EU_REACH: 4-methyldec-3-en-5-ol",,81782-77-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12744/7/4/2/?documentUUID=e7f65251-245d-4c40-849c-1028db866384,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCC(/C(=C/CC)/C)O,https://pubchem.ncbi.nlm.nih.gov/compound/6441135,PubChem,CC/C=C(\C)C(O)CCCCC,Train "EU_REACH: 2-[(1E)-2-(2-methoxyphenyl)diazen-1-yl]-3-oxo-N-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl)butanamide",,82199-12-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5446/7/4/2/?documentUUID=98595a51-8f6b-4a24-9748-0bbe11174160,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC2=C(C=C1)NC(=O)N2)N=NC3=CC=CC=C3OC,https://pubchem.ncbi.nlm.nih.gov/compound/174265,PubChem,COc1ccccc1N=NC(C(C)=O)C(=O)Nc1ccc2[nH]c(=O)[nH]c2c1,Train "EU_REACH: 1-hydroxy-1,2-dihydropyridin-2-one",,822-89-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26617/7/4/2/?documentUUID=a85f74e3-7b99-4640-ba82-ccadce8bd02b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=O)N(C=C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/69975,PubChem,O=c1ccccn1O,Train "EU_REACH: (4E)-3-methylcyclopentadec-4-en-1-one; (5E)-3-methylcyclopentadec-5-en-1-one; (5Z)-3-methylcyclopentadec-5-en-1-one",,82356-51-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16261/7/4/2/?documentUUID=cbb227f1-859f-4e56-87bc-53e7f494d013,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C/C/1=C/CCCCCCCCCCCCC1=O,https://pubchem.ncbi.nlm.nih.gov/compound/92043557,PubChem,C/C1=C/CCCCCCCCCCCCC1=O,Train "NZ_CCID: 3-Bromobenzyl bromide",,823-78-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/69FA01C0-4A55-441B-AF98-675925FFB27E,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)Br)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/69979,PubChem,BrCc1cccc(Br)c1,Train "NZ_CCID: Dichlorophenylphosphine oxide",,824-72-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/78E2D2DC-D3EE-47D2-90BF-C77198CAC8FC,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC=C(C=C1)P(=O)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/69990,PubChem,O=P(Cl)(Cl)c1ccccc1,Train "NZ_CCID: 3-Methoxybenzyl chloride",,824-98-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8D69766A-B0F4-4FE2-A420-63EB15E4C4F9,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,COC1=CC=CC(=C1)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/69994,PubChem,COc1cccc(CCl)c1,Train "EU_REACH: 4-chlorobutyl 3-chloropropanoate",,82530-64-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33473/7/4/2/?documentUUID=7a562632-4f5b-40cb-afd5-1f69e1f2afa1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CCCl)COC(=O)CCCl,https://pubchem.ncbi.nlm.nih.gov/compound/11275655,PubChem,O=C(CCCl)OCCCCCl,Train "EU_REACH: 4-(4-butylphenyl)-4'-ethyl-3-fluoro-1,1'-biphenyl",,825633-75-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21007/7/4/2/?documentUUID=45938635-2d93-4d92-a5fa-5435ab0246f1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC1=CC=C(C=C1)C2=C(C=C(C=C2)C3=CC=C(C=C3)CC)F,https://pubchem.ncbi.nlm.nih.gov/compound/59734846,PubChem,CCCCc1ccc(-c2ccc(-c3ccc(CC)cc3)cc2F)cc1,Train "JP_CHRIP: 2,2,6,6-Tetramethylpiperidin-4-one NZ_CCID: 2,2,6,6-Tetramethyl-4-piperidone","JP_CHRIP: 2,2,6,6-Tetramethyl-4-oxopiperidine 4-Piperidinone, 2,2,6,6-tetramethyl-",826-36-8,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0139e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0E9138E5-310A-49E1-A6F0-8DDB3429A025","JP_CHRIP: On the basis that a test (OECD TG 404) applied 500 mg to rabbit skin for 4 hours observed severe necrosis was discontinued due to severe damages after 24 hours and this substance was assessed as caustic as a result (BUA Report 255 (2006)), it was classified in Category 1. Furthermore, another test applied 500 mg to only a rabbit (OECD TG 404) was discontinued due to severe necrosis after 72 hours (BUA Report 255 (2006)), and it was also assessed as caustic. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",Provided,"JP_CHRIP, NZ_CCID",2,CC1(C)CC(=O)CC(C)(C)N1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J107D,J-GLOBAL,CC1(C)CC(=O)CC(C)(C)N1,Train "EU_REACH: 4-(butoxymethyl)-2-methoxyphenol",,82654-98-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1538/7/4/2/?documentUUID=b7412d20-feaf-4369-9569-121f177ac77f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOCC1=CC(=C(C=C1)O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/5084146,PubChem,CCCCOCc1ccc(O)c(OC)c1,Train "NZ_CCID: Diphenylcarbamyl chloride","NZ_CCID: N,N-Diphenylcarbamoyl chloride",83-01-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/442EEC7A-9E19-44F6-BF36-77F987A0694B,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41[CHEMWATCH]",,NZ_CCID,1,C1=CC=C(C=C1)N(C2=CC=CC=C2)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/65741,PubChem,O=C(Cl)N(c1ccccc1)c1ccccc1,Train "NZ_CCID: Ethanol, 2-((2-(2-(dimethylamino)ethoxy)ethyl)methylamino)-","NZ_CCID: 2-[(2-[2-(Dimethylamino)ethoxy]ethyl)methylamino]ethanol",83016-70-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8A074045-DADA-4EF7-A963-FD59ABCF5610,"NZ_CCID: Skin Irritation R PHRASE: R 34 [ECB] Eye Irritation R PHRASE: R 34 [ECB]",,NZ_CCID,1,CN(C)CCOCCN(C)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/3086157,PubChem,CN(C)CCOCCN(C)CCO,Train "EU_REACH: 2-(4-{4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]but-1-yn-1-yl}phenyl)-2-methylpropanoic acid",,832088-68-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5722/7/4/2/?documentUUID=48aa4e51-b9f8-4b64-893c-eafb17e46bcc,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C1=CC=C(C=C1)C#CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/11982796,PubChem,CC(C)(C(=O)O)c1ccc(C#CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,Train "JP_CHRIP: 2-ethylamino-4-isopropylamino-6-methylthio-1,3,5-triazine; Ametryn","JP_CHRIP: 1,3,5-Triazine-2,4-diamine, N-ethyl-N'-(1-methylethyl)-6-(methylthio)- 2-ethylamino-4-isopropylamino-6-methylthio-1,3,5-trizaine [synonym:Ametryne] N-ethyl-N'-isopropyl-6-methylthio-1,3,5-trizaine-2,4-diamine (synonym:2-ethylamino-4-isopropylamino-6-methylthio-1,3,5-trizaine or Ametryne)",834-12-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2096e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" (corresponding to Category 3 in UN GHS classification) from (1) - (4). [Evidence Data] (1) In a skin irritation test with rabbits according to EPA OPPTS 870.2500, it was judged as not an irritant (EPA Pesticides RED (2005)). (2) In eye and skin irritation tests with rabbits, this substance was judged as negative by the US EPA but as slightly irritating by APVMA, Australia (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2007)). (3) It is reported that this substance was slightly irritating to the skin of rabbits (Patty (6th, 2012)). (4) In a skin irritation test with rabbits according to OECD TG 404 on this substance, very slight erythema was noted one hour after patch removal but disappeared within 24 hours (REACH registration dossier (Access on September 2020)). [Reference Data, etc.] (5) In a skin irritation test with rabbits on a formulation of this substance (emulsion), slight irritation was observed, erythema disappeared after 14 days, and edema disappeared by day 4 (Japanese Journal of Pesticide Science Vol. 18, No. 4 (Pesticide Science Society of Japan, 1993)). (6) In a skin irritation test with rabbits on a formulation of this substance (wettable powder), no irritation was found (Japanese Journal of Pesticide Science Vol. 18, No. 4 (Pesticide Science Society of Japan, 1993)).",Provided,JP_CHRIP,1,CCNc1nc(NC(C)C)nc(SC)n1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.651J,J-GLOBAL,CCNc1nc(NC(C)C)nc(SC)n1,Train "EU_REACH: naphthalene-1,5-diol",,83-56-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27320/7/4/2/?documentUUID=742c964e-ba81-4252-a40e-2fbc701bebf0,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC2=C(C=CC=C2O)C(=C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/6749,PubChem,Oc1cccc2c(O)cccc12,Train "EU_REACH: 4-cyanophenyl 4-{[6-(prop-2-enoyloxy)hexyl]oxy}benzoate",,83847-14-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22993/7/4/2/?documentUUID=0ec426dd-564c-43e5-a836-58d277a499e5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CC(=O)OCCCCCCOC1=CC=C(C=C1)C(=O)OC2=CC=C(C=C2)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/640210,PubChem,C=CC(=O)OCCCCCCOc1ccc(C(=O)Oc2ccc(C#N)cc2)cc1,Train "EU_REACH: methyl 4-[(2,5-dichlorophenyl)carbamoyl]-2-nitrobenzoate",,83929-47-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10413/7/4/2/?documentUUID=31bc5513-c8b1-4f6e-8666-16535d2e7d92,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1=C(C=C(C=C1)C(=O)NC2=C(C=CC(=C2)Cl)Cl)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/3019490,PubChem,COC(=O)c1ccc(C(=O)Nc2cc(Cl)ccc2Cl)cc1[N+](=O)[O-],Train "EU_REACH: 1-(DIPHENYLMETHYL)PIPERAZINE",,841-77-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24243/7/4/2/?documentUUID=27985cb6-78a0-4a4f-9d26-3f5104ca46b4,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CN(CCN1)C(C2=CC=CC=C2)C3=CC=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/70048,PubChem,c1ccc(C(c2ccccc2)N2CCNCC2)cc1,Train "EU_REACH: 2-ethyl-9,10-anthraquinone",,84-51-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14500/7/4/2/?documentUUID=1a1592fb-f49c-48aa-8b1d-f2272d637971,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1=CC2=C(C=C1)C(=O)C3=CC=CC=C3C2=O,https://pubchem.ncbi.nlm.nih.gov/compound/6772,PubChem,CCc1ccc2c(c1)C(=O)c1ccccc1C2=O,Train "EU_REACH: 3-amino-2-chloro-6-methylphenol",,84540-50-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21096/7/4/2/?documentUUID=a0360467-cd07-4c16-95f3-27880a3e11fb,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C(=C(C=C1)N)Cl)O,https://pubchem.ncbi.nlm.nih.gov/compound/157641,PubChem,Cc1ccc(N)c(Cl)c1O,Train "EU_REACH: 3,6-bis(4-methylphenyl)-1H,2H,4H,5H-pyrrolo[3,4-c]pyrrole-1,4-dione",,84632-66-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17046/7/4/2/?documentUUID=bca4fda5-5c79-47a9-8a48-69a632377f1e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)C2=C3C(=C(N2)O)C(=NC3=O)C4=CC=C(C=C4)C,https://pubchem.ncbi.nlm.nih.gov/compound/135565865,PubChem,Cc1ccc(C2=NC(=O)c3c(-c4ccc(C)cc4)[nH]c(O)c32)cc1,Train "JP_CHRIP: 9,10-Anthraquinone","JP_CHRIP: 9,10-Anthracendione 9,10-Anthracenedione anthraquinone Diphenyl ketone",84-65-1,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0053e.html,"JP_CHRIP: It was classified as ""Not classified"" because it was not irritating in a skin irritation test with rabbits (OECD TG 404) (IUCLID (2000)). Besides, it is also reported that it was not irritating in another test by a 24-hour semi-occlusive application of 500 microL or 0.5 g to the rabbit skin (IUCLID (2000)).",Provided,JP_CHRIP,1,O=C1c2ccccc2C(=O)c2ccccc12,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J294A,J-GLOBAL,O=C1c2ccccc2C(=O)c2ccccc21,Train "EU_REACH: (1r,1's,4r,4'r)-4-(4-methylphenyl)-4'-propyl-1,1'-bi(cyclohexane)",,84656-75-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21867/7/4/2/?documentUUID=2d87d580-c0c5-4780-b008-3fcf2574eae3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1CCC(CC1)C2CCC(CC2)C3=CC=C(C=C3)C,https://pubchem.ncbi.nlm.nih.gov/compound/576378,PubChem,CCCC1CCC(C2CCC(c3ccc(C)cc3)CC2)CC1,Train "JP_CHRIP: Diisobutyl phthalate","JP_CHRIP: 1,2-Benzenedicarboxylic acid, bis-(2-methoxypropyl)ester Di(isobutyl)-1,2-benzenedicarboxylate DIBP Phthalic acic, diisobutyl ester",84-69-5,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-meti-2008e.html,"JP_CHRIP: [Rationale for the Classification] Based on (1)-(4), it was classified as ""Not classified."" [Evidence Data] (1) There is a report that this substance is not irritating in an in vitro test (OECD TG431, GLP-compliant) (REACH registration dossier (Accessed Dec. 2018)). (2) There is a report that in a skin irritation test with rabbits, in which the undiluted liquid of this substance was applied occlusively for 20 hours, after 7 days, the erythema score was 0.5 and the edema score was 0 (REACH registration dossier (Accessed Dec. 2018)). (3) There is a report that in a skin irritation test (OECD TG 404, n=3) with rabbits, no irritation was observed when the undiluted liquid of this substance was applied for 4 hours (BUA 201 (1997)). (4) There is a report that this substance is not skin irritating (Patty (6th, 2012)). [Reference Data, etc.] (5) There are reports that this substance is not irritating to the skin in rabbits and slightly irritating to the skin in guinea pigs (CPSC (2011)).",Provided,JP_CHRIP,1,CC(C)COC(=O)c1ccccc1C(=O)OCC(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.535A,J-GLOBAL,CC(C)COC(=O)c1ccccc1C(=O)OCC(C)C,Train "JP_CHRIP: Di-n-butyl phthalate","JP_CHRIP: 1,2-Benzenedicarboxylic acid dibutyl ester 1,2-Benzenedicarboxylic acid, dibutyl ester Di-n-butyl phthalate dibutyl benzene-1,2-dicarboxylate dibutyl phthalate Dibutyl phthalate; Dibutyl phthalate Dibutyl-1,2-benzenedicarboxylate",84-74-2,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-2015e.html,"JP_CHRIP: It is described in the Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), EU-RAR (2003) that skin irritation was observed, but it is described in EU-RAR (2004) (Addendum to the Environmental Section), which is an addendum to EU-RAR (2003), that a test according to OECD TG404 resulted in no irritation, and it is concluded in EU-RAR (2004) that there was no irritation. Therefore, it was classified as ""Not classified"" (Category 3 in UN GHS classification).",Provided,JP_CHRIP,1,CCCCOC(=O)c1ccccc1C(=O)OCCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.882B,J-GLOBAL,CCCCOC(=O)c1ccccc1C(=O)OCCCC,Train "EU_REACH: (1R,2S,5R)-5-methyl-2-(propan-2-yl)-N-[2-(pyridin-2-yl)ethyl]cyclohexanecarboxamide",,847565-09-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2631/7/4/2/?documentUUID=63dad0b9-5dc4-4559-b9b8-17ea8b2233ae,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H]1CC[C@H]([C@@H](C1)C(=O)NCCC2=CC=CC=N2)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/25126651,PubChem,CC(C)[C@@H]1CC[C@@H](C)C[C@H]1C(=O)NCCc1ccccn1,Train "AU_HCIS: 4-nonylphenol, branched JP_CHRIP: 4-Nonylphenol (branched) KR_NCIS: Nonylphenols NZ_CCID: Nonylphenol, 4-branched","AU_HCIS: Phenol, 4-nonyl-, branched JP_CHRIP: 4-Nonylphenol, branched Branched 4-nonylphenol Branched p-nonylphenol; C9 branched alkyl phenol; Nonylphenol; Phenol, 4-nonyl-, branched KR_NCIS: 4-Nonylphenol, branched; Branched p-nonylphenol; C9 branched alkyl phenolBranched 4-nonylphenol NZ_CCID: Monononylphenol, Nonanal-methyl anthranilate, Phenol, 4-nonyl-, branched",84852-15-3,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3266 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0030e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F94128D9-B89D-4974-93FA-01BF21BDF38B","JP_CHRIP: In the rabbit test (OECD TG 404), occlusive administration of 0.5 ml of test substance caused mild to moderate erythema, and mild to moderate edema at 3 minutes of exposure, moderate erythema and severe edema at 4 hours, subsequently, epidermal necrosis, full-thickness skin necrosis, fissure, exfoliation, ulceration, loss of hair, crust formation and cicatrization were observed. The substance was classified as Category 1 since the symptoms were not reversible (Initial Risk Assessment Report (NITE, CERI, NEDO) (2005)). NZ_CCID: Skin Irritation R PHRASE: R 34 [NCLASS] Eye Irritation SPECIES: Rabbit RESULT: According to the degree of injury observed after 24 hours have been rated on a scale of 1 to 10 (the most severely injurious substances have been rated 10), a 10. REFERENCE SOURCE: Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986. 1047 **PEER REVIEWED** [HSDB]",Provided,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID",4,CC(C)CCCCCCc1ccc(O)cc1,https://cactus.nci.nih.gov/chemical/structure/84852-15-3/smiles,CACTUS,CC(C)CCCCCCc1ccc(O)cc1,Train "EU_REACH: 2-[[4-(diethylamino)-2-methylphenyl]azo]-5-nitrobenzene-1,3-dicarbonitrile",,84870-65-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21423/7/4/2/?documentUUID=7b9f3905-5769-472a-a721-8af49966f5c7,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN(CC)C1=CC(=C(C=C1)N=NC2=C(C=C(C=C2C#N)[N+](=O)[O-])C#N)C,https://pubchem.ncbi.nlm.nih.gov/compound/3020191,PubChem,CCN(CC)c1ccc(N=Nc2c(C#N)cc([N+](=O)[O-])cc2C#N)c(C)c1,Train "EU_REACH: 1,3,5-triisopropyl-2,4-dinitrobenzene",,85187-23-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11287/7/4/2/?documentUUID=1081bbfe-0c96-407d-ad47-644496acea1a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C1=CC(=C(C(=C1[N+](=O)[O-])C(C)C)[N+](=O)[O-])C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/3020492,PubChem,CC(C)c1cc(C(C)C)c([N+](=O)[O-])c(C(C)C)c1[N+](=O)[O-],Train "KR_NCIS: Bis(1,1-dimethylethyl)[[(trifluoromethyl)sulfonyl]oxy]silyl 1,1,1-trifluoromethanesulfonate",,85272-31-7,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CC(C)(C)[Si](C(C)(C)C)(OS(=O)(=O)C(F)(F)F)OS(=O)(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/545813,PubChem,CC(C)(C)[Si](OS(=O)(=O)C(F)(F)F)(OS(=O)(=O)C(F)(F)F)C(C)(C)C,Train "EU_REACH: 4-(1-phenylethyl)benzene-1,3-diol",,85-27-8,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11024/7/4/2/?documentUUID=f28b4620-fd19-4c60-9dde-cf8b9452769d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C1=CC=CC=C1)C2=C(C=C(C=C2)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/11171903,PubChem,CC(c1ccccc1)c1ccc(O)cc1O,Train "EU_REACH: 2,3,3a,4,7,7a-hexahydro-1H-isoindole-1,3-dione",,85-40-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1194/7/4/2/?documentUUID=e6a19792-1bd7-488f-a03a-87d77bf19551,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C=CCC2C1C(=O)NC2=O,https://pubchem.ncbi.nlm.nih.gov/compound/6808,PubChem,O=C1NC(=O)C2CC=CCC12,Train "NZ_CCID: 1-Naphthalenesulphonyl chloride",,85-46-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9A2D4A0C-FC49-45E0-A72F-4F0E34F49525,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC=C2C(=C1)C=CC=C2S(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/66560,PubChem,O=S(=O)(Cl)c1cccc2ccccc12,Train "EU_REACH: 5-hept-6-enyloxolan-2-one",,854737-08-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33826/7/4/2/?documentUUID=fcfe1616-315b-42d9-9865-064e2e03da5d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CCCCCCC1CCC(=O)O1,https://pubchem.ncbi.nlm.nih.gov/compound/86055585,PubChem,C=CCCCCCC1CCC(=O)O1,Train "JP_CHRIP: Chlorinated paraffin (C=14-17)",,85535-85-9,NC,JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-0016.html,"JP_CHRIP: 【分類根拠】 （１）、（２）より、区分に該当しない（国連分類基準の区分3）。 【根拠データ】 （１）本物質（塩素含有率：40％）について、ウサギ（n=6）を用いた皮膚刺激性試験（OECD TG 404、閉塞、4時間適用、14日観察）において、皮膚の乾燥・硬化と皮膚外層の剥離が72時間後及び6～8日後に、痂皮鱗片化が6～10日後にみられた（適用24/48/72h後の紅斑・痂皮スコアの平均：1.5、浮腫スコアの平均：0.6）との報告がある（AICIS IMAP (2015)、REACH登録情報 (Accessed May 2021)）。 （２）本物質（塩素含有率：52％）について、ウサギ（n=6）を用いた皮膚刺激性試験（OECD TG 404、閉塞、4時間適用、14日観察）において、適用6～10日後に痂皮鱗片化がみられた（適用24/48/72h後の紅斑・痂皮スコアの平均：1.3、浮腫スコアの平均：0.3）との報告がある（AICIS IMAP (2015)、REACH登録情報 (Accessed May 2021)）。",Provided,JP_CHRIP,1,CC(CC(CC(CCCC(CC(CC(C)Cl)Cl)Cl)Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/121232961,PubChem,CC(Cl)CC(Cl)CC(Cl)CCCC(Cl)CC(Cl)CC(C)Cl,Train "KR_NCIS: N-Methyl-2,4-cyclopentadiene-1-ethanamine",,857023-53-1,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CNCCC1C=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/12109886,PubChem,CNCCC1C=CC=C1,Train "EU_REACH: 2-(trifluoromethyl)benzenesulfonyl isocyanate",,85813-73-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10851/7/4/2/?documentUUID=bf564dfc-00f2-4653-9afc-7849a031035a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C(=C1)C(F)(F)F)S(=O)(=O)N=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/11817579,PubChem,O=C=NS(=O)(=O)c1ccccc1C(F)(F)F,Train "KR_NCIS: Tridecylamine, branched and linear",,86089-17-0,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCCC(CC)CCCCCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/22833454,PubChem,CCCC(CC)CCCCCCCN,Train "EU_REACH: 2-(2-oxoimidazolidin-1-yl)ethyl methacrylate",,86261-90-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13683/7/4/2/?documentUUID=c01bffd2-ac73-4827-9ed0-e2cc72062696,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OCCN1CCNC1=O,https://pubchem.ncbi.nlm.nih.gov/compound/643493,PubChem,C=C(C)C(=O)OCCN1CCNC1=O,Train "EU_REACH: 9-ethyl-9H-carbazole",,86-28-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5801/7/4/2/?documentUUID=1685823b-dd0c-476c-8ff1-a9ba327832c5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN1C2=CC=CC=C2C3=CC=CC=C31,https://pubchem.ncbi.nlm.nih.gov/compound/6836,PubChem,CCn1c2ccccc2c2ccccc21,Train "NZ_CCID: 1-(Chloromethyl) naphthalene",,86-52-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/607893E1-BDAE-4203-AD22-853C31CE5B76,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C2C(=C1)C=CC=C2CCl,https://pubchem.ncbi.nlm.nih.gov/compound/6845,PubChem,ClCc1cccc2ccccc12,Train "EU_REACH: 617-879-7",,865536-03-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21282/7/4/2/?documentUUID=44846f64-ce62-495e-bfbb-3fcf9936bf78,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=CC=C1NC(=O)OCCCCCCCCCCC(C)C)NC(=O)NCC2=CC(=CC=C2)CNC(=O)NC3=C(C(=CC=C3)NC(=O)OCCCCCCCCCCC(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/154734779,PubChem,Cc1c(NC(=O)NCc2cccc(CNC(=O)Nc3cccc(NC(=O)OCCCCCCCCCCC(C)C)c3C)c2)cccc1NC(=O)OCCCCCCCCCCC(C)C,Train "EU_REACH: (3AS,4S,6AR)-4-METHOXYTETRAHYDROFURO[3,4- B]FURAN-2(3H)-ONE",,866594-60-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25324/7/4/2/?documentUUID=97f48c94-4a3a-431e-aced-f6ffeca508c4,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CO[C@@H]1[C@H]2CC(=O)O[C@H]2CO1,https://pubchem.ncbi.nlm.nih.gov/compound/11600708,PubChem,CO[C@H]1OC[C@@H]2OC(=O)C[C@H]12,Train "EU_REACH: [(2R,3R,4R,5S,6S)-3,4,5-tris(acetyloxy)-6-(3-{[5-(4-fluorophenyl)thiophen-2-yl]methyl}-4-methylphenyl)oxan-2-yl]methyl acetate",,866607-35-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30373/7/4/2/?documentUUID=ad783eea-1de3-4f27-b407-aa326147fcc5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)COC(=O)C)OC(=O)C)OC(=O)C)OC(=O)C)CC3=CC=C(S3)C4=CC=C(C=C4)F,https://pubchem.ncbi.nlm.nih.gov/compound/25224976,PubChem,CC(=O)OC[C@H]1O[C@@H](c2ccc(C)c(Cc3ccc(-c4ccc(F)cc4)s3)c2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,Train "EU_REACH: Benzoic acid, 4-[ (1-oxodecyl) oxy]-",,86960-46-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5452/7/4/2/?documentUUID=ae5e57d1-142b-41de-ab6a-9a19ba0e2a8c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCC(=O)OC1=CC=C(C=C1)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/3608562,PubChem,CCCCCCCCCC(=O)Oc1ccc(C(=O)O)cc1,Train "EU_REACH: 3,3,10,10-tetramethoxy-2,11-dioxa-3,10-disiladodecane",,87135-01-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1492/7/4/2/?documentUUID=cfdfc51e-e9fa-425f-a99b-bb66468020d2,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CO[Si](CCCCCC[Si](OC)(OC)OC)(OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/159046,PubChem,CO[Si](CCCCCC[Si](OC)(OC)OC)(OC)OC,Train "EU_REACH: octadecanedioic acid",,871-70-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5505/7/4/2/?documentUUID=c24ff0c1-e46d-468a-b3fe-2ff1df3c125d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CCCCCCCCC(=O)O)CCCCCCCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/70095,PubChem,O=C(O)CCCCCCCCCCCCCCCCC(=O)O,Train "EU_REACH: Bis(2-ethylhexyl) 2-(4-hydroxy-3,5-dimethoxybenzyl)propanedioate",,872182-46-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/4368/7/4/2/?documentUUID=684cac9b-1d6b-4687-ba4e-398a9d852532,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)C(CC1=CC(=C(C(=C1)OC)O)OC)C(=O)OCC(CC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/11961068,PubChem,CCCCC(CC)COC(=O)C(Cc1cc(OC)c(O)c(OC)c1)C(=O)OCC(CC)CCCC,Train "EU_REACH: ethyl {[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]amino}acetate",,872728-83-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16526/7/4/2/?documentUUID=291fcd61-3684-449b-b335-4b4b7a36c007,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)CNC1=CC=C(C=C1)C2=NOC(=O)N2,https://pubchem.ncbi.nlm.nih.gov/compound/135741406,PubChem,CCOC(=O)CNc1ccc(-c2noc(=O)[nH]2)cc1,Train "EU_REACH: (4Z)-hept-4-en-2-yl salicylate",,873888-84-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1703/7/4/2/?documentUUID=b81c72b0-8edc-4600-92be-3c0cdb9264a0,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC/C=C\CC(C)OC(=O)C1=CC=CC=C1O,https://pubchem.ncbi.nlm.nih.gov/compound/67480918,PubChem,CC/C=C\CC(C)OC(=O)c1ccccc1O,Train "EU_REACH: N-{2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)carbonyl]-6-fluorophenyl}-1,1-difluoro-N-methylmethanesulfonamide",,874195-61-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6582/7/4/2/?documentUUID=442ff565-b688-403e-a0b3-1ddce977f863,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C1=C(C=CC=C1F)C(=O)C2=NC(=NC(=N2)OC)OC)S(=O)(=O)C(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/16004663,PubChem,COc1nc(OC)nc(C(=O)c2cccc(F)c2N(C)S(=O)(=O)C(F)F)n1,Train "NZ_CCID: 4-Toluoyl chloride","NZ_CCID: p-toluoyl chloride",874-60-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/826D83EC-F9CE-45C8-A978-BC125BE485DF,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC1=CC=C(C=C1)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/13405,PubChem,Cc1ccc(C(=O)Cl)cc1,Train "JP_CHRIP: Mucochloric acid NZ_CCID: Dichloromalealdehydic acid","JP_CHRIP: Mucochloric acid NZ_CCID: mucochloric acid",87-56-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0034e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/83AF56F1-F1C8-451B-9766-5B4DFF295F77","JP_CHRIP: In a test by a 4-hour occlusive application of 0.5 g of an 80% aqueous solution of this substance to the skin of two rabbits (Test guidelines of the US Department of Transportation), the average scores after 4 hours, 1 day, 2 days, and 8 days were 3.5, 4, 4, 4, respectively for erythema, and 3, 3, 3, 1.5 for edema, and it was assessed to be corrosive (SIDS (2003)). Therefore, it was classified in Category 1. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,OC(=O)/C(=C(/Cl)\C=O)/Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.902K,J-GLOBAL,O=C/C(Cl)=C(/Cl)C(=O)O,Train "EU_REACH: (2R,3R)-2,3-dihydroxybutanedioic acid",,87-69-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15126/7/4/2/?documentUUID=b4aed523-b21d-4080-a48f-d6e88c261d06,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,[C@@H]([C@H](C(=O)O)O)(C(=O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/444305,PubChem,O=C(O)[C@H](O)[C@@H](O)C(=O)O,Train "EU_REACH: N-{3',4'-dichloro-5-fluoro-[1,1'-biphenyl]-2-yl}acetamide",,877179-03-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29709/7/4/2/?documentUUID=ba837944-2e4e-4950-aa24-41318a3388ae,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)NC1=C(C=C(C=C1)F)C2=CC(=C(C=C2)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/44139270,PubChem,CC(=O)Nc1ccc(F)cc1-c1ccc(Cl)c(Cl)c1,Train "EU_REACH: 3',4'-dichloro-5-fluorobiphenyl-2-amine",,877179-04-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8025/7/4/2/?documentUUID=64a20569-b236-4fd4-bd83-b681b09b7437,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C=C1C2=C(C=CC(=C2)F)N)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/11572419,PubChem,Nc1ccc(F)cc1-c1ccc(Cl)c(Cl)c1,Train "EU_REACH: (1S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol",,877397-65-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10776/7/4/2/?documentUUID=fcabcf14-fd44-4b7b-93e0-313b46212807,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H](C1=C(C=CC(=C1Cl)F)Cl)O,https://pubchem.ncbi.nlm.nih.gov/compound/11557536,PubChem,C[C@H](O)c1c(Cl)ccc(F)c1Cl,Train "EU_REACH: 5-bromo-3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine",,877399-00-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11079/7/4/2/?documentUUID=4983e025-4007-4692-a10b-66797ac54227,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)Br)N,https://pubchem.ncbi.nlm.nih.gov/compound/11689426,PubChem,C[C@@H](Oc1cc(Br)cnc1N)c1c(Cl)ccc(F)c1Cl,Train "EU_REACH: (1R)-1-[(4R,4aR,8aS)-2,6-bis(4-methylphenyl)-hexahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol",,87826-41-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6843/7/4/2/?documentUUID=e5752db4-0593-43fc-bed7-b6f88bf9714c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C/C(=C(/O)\[C@H](O)[C@@H](O)[C@H](O)[C@H](O)/C(=C(/C1=CC=CC=C1)\C)/O)/C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/90474944,PubChem,C/C(=C(/O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)/C(O)=C(\C)c1ccccc1)c1ccccc1,Train "EU_REACH: N-[ethenyl(N-ethylacetamido)methylsilyl]-N-ethylacetamide",,87855-59-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7533/7/4/2/?documentUUID=9d6a6151-c7cb-4b18-972b-bba8707f140b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN(C(=O)C)[Si](C)(C=C)N(CC)C(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/14440330,PubChem,C=C[Si](C)(N(CC)C(C)=O)N(CC)C(C)=O,Train "EU_REACH: 3-(dodecylsulfanyl)-1-[(1S,2R)-2,6,6-trimethylcyclohex-3-en-1-yl]butan-1-one",,878665-13-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16259/7/4/2/?documentUUID=f1db150b-c66e-4082-927b-024e1d791f32,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCSC(C)CC(=O)[C@@H]1[C@H](C=CCC1(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/101391704,PubChem,CCCCCCCCCCCCSC(C)CC(=O)[C@@H]1[C@@H](C)C=CCC1(C)C,Train "NZ_CCID: 1-Naphthalenecarbonyl chloride",,879-18-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/66561D91-1E74-4479-A271-0A3EE95FB03A,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC=C2C(=C1)C=CC=C2C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/70146,PubChem,O=C(Cl)c1cccc2ccccc12,Train "EU_REACH: 2-ethoxy-N-hydroxybenzenecarboximidamide",,879-57-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20892/7/4/2/?documentUUID=dcdb399d-b9e9-49df-811b-1ac38197fba8,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC1=CC=CC=C1/C(=N/O)/N,https://pubchem.ncbi.nlm.nih.gov/compound/12052279,PubChem,CCOc1ccccc1/C(N)=N/O,Train "EU_REACH: 632-619-2",,881685-58-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33201/7/4/2/?documentUUID=5521856f-cc44-4006-8983-8344e04bca4d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C1C2CCC1C3=C2C=CC=C3NC(=O)C4=CN(N=C4C(F)F)C,https://pubchem.ncbi.nlm.nih.gov/compound/25271089,PubChem,CC(C)C1C2CCC1c1c(NC(=O)c3cn(C)nc3C(F)F)cccc12,Train "EU_REACH: 2-tert-butylphenol JP_CHRIP: 2-tert-Butylphenol NZ_CCID: 2-t-Butylphenol","JP_CHRIP: 2-(1,1-Dimethylethyl)phenol 2-tert-Butyl-1-hydroxybenzene o-tert-Butylphenol Phenol, 2-(1,1-dimethylethyl)- NZ_CCID: o-tert-butylphenol",88-18-6,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14446/7/4/2/?documentUUID=46d5c676-3066-419a-bc97-3dfae0db7624 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0058e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/422E8A3A-44DF-4CCC-BCD8-C221F1E45A09","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: In a skin irritation test by a 4-hour semi-occlusive application of 0.5 mL of the undiluted test substance to six rabbits (OECD TG404; GLP-compliant), all animals showed necrosis at 1-7 days after the application, and the primary skin irritation index was 5.67 (ECETOC TR66 (1995)). Therefore, it was classified in Category 1. Besides, it is described that this substance is strongly irritating or caustic to the skin and eyes (BUA 231 (2001)). NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",Provided,"EU_REACH, JP_CHRIP, NZ_CCID",3,CC(C)(C)c1ccccc1O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J44.174K,J-GLOBAL,CC(C)(C)c1ccccc1O,Train "EU_REACH: [(5-chloroquinolin-8-yl)oxy]acetic acid",,88349-88-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19352/7/4/2/?documentUUID=7da56792-d23b-471f-94cb-45c1bbd9578a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC2=C(C=CC(=C2N=C1)OCC(=O)O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/15257197,PubChem,O=C(O)COc1ccc(Cl)c2cccnc12,Train "EU_REACH: 1-{3-[(3-{2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecan-1-yl}propyl)disulfanyl]propyl}-2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecane",,883794-93-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11811/7/4/2/?documentUUID=09f79253-8a00-4d91-ada8-94db36a83154,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CO[Si]2(OCCN1CCO2)CCCSSCCC[Si]34OCCN(CCO3)CCO4,https://pubchem.ncbi.nlm.nih.gov/compound/4276941,PubChem,C(CSSCCC[Si]12OCCN(CCO1)CCO2)C[Si]12OCCN(CCO1)CCO2,Train "JP_CHRIP: 2-tert-Butyl-5-methylphenol","JP_CHRIP: 6-tert-butyl-m-cresol 6-tert-Butyl-m-cresol; 2-tert-Butyl-5-methylphenol",88-60-8,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-meti-0055e.html,"JP_CHRIP: There are descriptions, ""The primary dermal stimulation score was from 5.44 to severe skin irritation"" (GLP)in the Draize test where this substance was administered to rabbits for 4 hours, ""moderate erythema , severe edema or hardening of the skin were observed until 2weeks after the admiration"" and it is concluded in SIDS to be ""corrosive against the skin"", it was classified in Category 1.",,JP_CHRIP,1,Cc1ccc(c(O)c1)C(C)(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J101.497H,J-GLOBAL,Cc1ccc(C(C)(C)C)c(O)c1,Train "EU_REACH: 2-(4-chlorophenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]hexanenitrile JP_CHRIP: myclobutanil; 2-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)hexanenitrile","JP_CHRIP: Myclobutanil",88671-89-0,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33152/7/4/2/?documentUUID=7165c20a-0a74-4596-809d-71c173060645 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0300e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: Based on the report that the substance was found to be not irritating in rabbit tests (JMPR (1992)).",Provided,"EU_REACH, JP_CHRIP",2,CCCCC(Cn1cncn1)(C#N)c1ccc(Cl)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J343.426E,J-GLOBAL,CCCCC(C#N)(Cn1cncn1)c1ccc(Cl)cc1,Train "JP_CHRIP: 2-Nitrotoluene","JP_CHRIP: 1-Methyl-2-nitrobenzene Benzene, 1-methyl-2-nitro- o-Methylnitrobenzene o-Mononitrotoluene o-Nitrotoluene ONT",88-72-2,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2010e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1) - (4). [Evidence Data] (1) This substance was not irritating to the rabbit skin (Risk Assessment Report (Ministry of Health, Labour and Welfare, 2009)). (2) It was reported to be not irritating in a skin irritation test by 4-hour semi-occlusive application of this substance (purity 99.2%, 0.5 mL) to rabbits. Other than this, it was reported to be not irritating in three skin irritation tests by 24-hour application to the rabbit skin (EURAR (2008), AICIS IMAP (Access on April 2020)). (3) This substance is not irritating to the skin and eye (MAK (DFG) vol.8 (1997), SIAP (1994), GESTIS (Access on April 2020)). (4) There was no irritation in a skin irritation test with rabbits (24-hour occlusive application) similar to OECD TG 404 (REACH registration dossier (Access on May 2020)) [Reference Data, etc.] (5) This substance irritates the skin, eye, and respiratory tract (HSDB (Access on April 2020)).",Provided,JP_CHRIP,1,Cc1ccccc1[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.906C,J-GLOBAL,Cc1ccccc1[N+](=O)[O-],Train "JP_CHRIP: 2-(1-Methylpropyl)-4,6-dinitrophenol","JP_CHRIP: 2,4-Dinitro-6-(1-methylpropyl)phenol 2,4-Dinitro-6-sec-butylphenol 2-(1-Methylpropyl)-4,6-dinitrophenol 4,6-Dinitro-2-sec-butylphenol Dinoseb Phenol, 2-(1-methylpropyl)-4,6-dinitro-",88-85-7,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0314e.html,"JP_CHRIP: Based on the description of the human health effects (CERI Hazard Data 2001-15 (2002)): ""Corrosive to the skin."" Although classified into Category 1A-1C, the substance should be placed in Category 1A from the viewpoint of safety if further subclassification is needed.",,JP_CHRIP,1,CCC(C)c1cc(cc(c1O)[N+](=O)[O-])[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.909H,J-GLOBAL,CCC(C)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1O,Train "EU_REACH: 3,6-bis({[1,1'-biphenyl]-4-yl})-1H,2H,4H,5H-pyrrolo[3,4-c]pyrrole-1,4-dione",,88949-33-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7888/7/4/2/?documentUUID=c6528a2f-4bd2-4821-8809-91966c585a95,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C2=CC=C(C=C2)C3=C4C(=C(N3)O)C(=NC4=O)C5=CC=C(C=C5)C6=CC=CC=C6,https://pubchem.ncbi.nlm.nih.gov/compound/135401970,PubChem,O=C1N=C(c2ccc(-c3ccccc3)cc2)c2c(O)[nH]c(-c3ccc(-c4ccccc4)cc3)c21,Train "NZ_CCID: Phthaloyl dichloride","NZ_CCID: phthaloyl chloride",88-95-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F4767F61-37AA-4D16-9069-FB0F79981745,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)C(=O)Cl)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/6955,PubChem,O=C(Cl)c1ccccc1C(=O)Cl,Train "EU_REACH: 2-amino-5-cyano-N,3-dimethylbenzamide",,890707-29-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26859/7/4/2/?documentUUID=db07a0d4-2cd5-48e0-b352-5d6a2c92f104,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=CC(=C1N)C(=O)NC)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/25157282,PubChem,CNC(=O)c1cc(C#N)cc(C)c1N,Train "EU_REACH: 6'-(dibutylamino)-3'-methyl-2'-(phenylamino)-3H-spiro[2-benzofuran-1,9'-xanthen]-3-one",,89331-94-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15299/7/4/2/?documentUUID=5d8f544e-960a-40ff-bcd8-7ed7b0a82fd6,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCN(CCCC)C1=CC2=C(C=C1)C3(C4=CC=CC=C4C(=O)O3)C5=C(O2)C=C(C(=C5)NC6=CC=CC=C6)C,https://pubchem.ncbi.nlm.nih.gov/compound/3534526,PubChem,CCCCN(CCCC)c1ccc2c(c1)Oc1cc(C)c(Nc3ccccc3)cc1C21OC(=O)c2ccccc21,Train "EU_REACH: ethyl 5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylate",,89-33-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6994/7/4/2/?documentUUID=fc6d4eca-2587-4e9a-bc52-566477b76487,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1=NN(C(=O)C1)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/66636,PubChem,CCOC(=O)C1=NN(c2ccccc2)C(=O)C1,Train "EU_REACH: phenyl N-(4,6-dimethoxypyrimidin-2-yl)carbamate",,89392-03-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7766/7/4/2/?documentUUID=803c9759-7b81-44e3-bf4d-2abb6e1ed07c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC(=NC(=N1)NC(=O)OC2=CC=CC=C2)OC,https://pubchem.ncbi.nlm.nih.gov/compound/10945667,PubChem,COc1cc(OC)nc(NC(=O)Oc2ccccc2)n1,Train "EU_REACH: 1,4-dimethoxy-2-nitrobenzene",,89-39-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5700/7/4/2/?documentUUID=ea9d5940-c2a3-4601-aa69-163a0b2a971f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC(=C(C=C1)OC)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/66639,PubChem,COc1ccc(OC)c([N+](=O)[O-])c1,Train "EU_REACH: 4-methoxy-3-nitrobenzoic acid",,89-41-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7180/7/4/2/?documentUUID=847f2149-976e-4370-9f96-a4ab4858a8df,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=C(C=C(C=C1)C(=O)O)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/66640,PubChem,COc1ccc(C(=O)O)cc1[N+](=O)[O-],Train "EU_REACH: 2-[2-(oxolan-2-yl)propan-2-yl]oxolane",,89686-69-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8620/7/4/2/?documentUUID=e6d005e8-332f-45f6-aa97-d37dfec19a3a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C1CCCO1)C2CCCO2,https://pubchem.ncbi.nlm.nih.gov/compound/551484,PubChem,CC(C)(C1CCCO1)C1CCCO1,Train "JP_CHRIP: o-sec-Butylphenol","JP_CHRIP: 2-(1-Methylpropyl)phenol o-sec-Butylphenol Phenol, 2-(1-methylpropyl)-",89-72-5,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2027e.html,"JP_CHRIP: In a skin irritation test (OECD TG 404) with rabbits, by application of 0.5 mL of the undiluted liquid of this substance for 3 minutes, moderate to severe edema was observed 1 hour after administration and slight edema was observed 7 days after administration, therefore, it is judged that it was a corrosive substance (SIDS (2013)). In addition, there is a report that it was corrosive in another test with rabbits (SIDS (2013)). Moreover, there is a report that skin burns occurred in occupational exposures (ACGIH (7th, 2001)). From the above, it was classified in Category 1. Besides, in the animal tests, since there were no descriptions on details such as the scores, sub-categorization was not conducted.",Provided,JP_CHRIP,1,CCC(C)c1ccccc1O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.214J,J-GLOBAL,CCC(C)c1ccccc1O,Train "EU_REACH: 2,4-dichlorobenzoyl chloride NZ_CCID: 2,4-Dichlorobenzoyl chloride",,89-75-8,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5926/7/4/2/?documentUUID=e85f5100-49c4-4e3c-827c-b39d85d762ca NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B07D0A57-89F5-4053-B32E-1C1DB870F195","EU_REACH: Experimental study (OECD TG 404, GLP) NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",Provided,"EU_REACH, NZ_CCID",2,C1=CC(=C(C=C1Cl)Cl)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/66645,PubChem,O=C(Cl)c1ccc(Cl)cc1Cl,Train "EU_REACH: methyl 4-(isocyanatosulfonyl)-5-methylthiophene-3-carboxylate",,897671-34-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13349/7/4/2/?documentUUID=b58dd102-91e7-4d8c-8fd1-a67fffaba4b7,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C(=CS1)C(=O)OC)S(=O)(=O)N=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/57957831,PubChem,COC(=O)c1csc(C)c1S(=O)(=O)N=C=O,Train "JP_CHRIP: thymol NZ_CCID: Thymol US_HSDB: THYMOL","NZ_CCID: Phenol, 5-methyl-2-(1-methylethyl)-, 5-Methyl-2-(1-methylethyl)phenol, Thyme camphor",89-83-8,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0143e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2B13D7AD-D9FD-4B91-8F17-E6BACE52A8EA US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/866","JP_CHRIP: Since it is documented that in a rabbit test (OECD TG 404), the substance was corrosive (IUCLID (2000)), and it is rated C; R34 in the EU classification, the substance was classified into Category 1. NZ_CCID: Skin Irritation R PHRASE: R 34 [EINECS] Eye Irritation R PHRASE: R 34 [EINECS]",Provided,"JP_CHRIP, NZ_CCID, US_HSDB",3,CC(C)c1ccc(C)cc1O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J10.606B,J-GLOBAL,Cc1ccc(C(C)C)c(O)c1,Train "EU_REACH: 2-(4-fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene",,898566-17-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27058/7/4/2/?documentUUID=9c4813d4-5f39-40c5-a422-19bc624986f7,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)I)CC2=CC=C(S2)C3=CC=C(C=C3)F,https://pubchem.ncbi.nlm.nih.gov/compound/45789954,PubChem,Cc1ccc(I)cc1Cc1ccc(-c2ccc(F)cc2)s1,Train "EU_REACH: 2,4-dihydroxybenzoic acid",,89-86-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20707/7/4/2/?documentUUID=5f072028-8ca1-4e6e-940a-9aea4e2bc414,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C=C1O)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/1491,PubChem,O=C(O)c1ccc(O)cc1O,Train "EU_REACH: 2,4-dimethyl-1-nitrobenzene",,89-87-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12516/7/4/2/?documentUUID=23d6e709-dc4b-49ab-a335-9e026a067948,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)[N+](=O)[O-])C,https://pubchem.ncbi.nlm.nih.gov/compound/6991,PubChem,Cc1ccc([N+](=O)[O-])c(C)c1,Train "EU_REACH: Glucose OxidaseIUBMB 1.1.3.4",,9001-37-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23509/7/4/2/?documentUUID=c71b49b1-8e6c-4d40-8652-fb237cfca0aa,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)O)O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/64689,PubChem,OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O,Train "EU_REACH: 2-hydroxybenzaldehyde",,90-02-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5715/7/4/2/?documentUUID=574b7695-9ddc-4762-bb66-59747059d3bc,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C(=C1)C=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/6998,PubChem,O=Cc1ccccc1O,Train "JP_CHRIP: o-Anisidine","JP_CHRIP: o-Methoxyaniline 1-Amino-2-methoxybenzene 2-methoxyaniline [synonym:o-anisidine] Benzenamine, 2-methoxy- o-Anisidine ortho-Anisidine",90-04-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-mhlw-2080e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (OECD TG404, GLP-compliant, n = 3), after 4-hour semi-occlusive application of undiluted this substance, erythema scores: 1 (2/3) and 0.7 (1/3) and a edema score: 0 were obtained after 72 hours, and animals fully recovered within 72 hours (DFGOT Vol.10 (1998), EU-RAR (2002), NICNAS IMAP (Accessed Dec. 2018), REACH registration dossier (Accessed Dec. 2018)). [Reference Data, etc.] (2) It is reported that in a skin irritation test with rabbits (n = 5), after 5-day open application of undiluted this substance, no irritation effects were seen after five days (REACH registration dossier (Accessed Dec. 2018)).",Provided,JP_CHRIP,1,COc1ccccc1N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.551C,J-GLOBAL,COc1ccccc1N,Train "EU_REACH: 4'-Ethyl-3-fluorbiphenyl-4-boronic acid",,900796-46-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26610/7/4/2/?documentUUID=a751f1c8-aff8-42dd-bdad-cceb70723755,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,B(C1=C(C=C(C=C1)C2=CC=C(C=C2)CC)F)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/53402575,PubChem,CCc1ccc(-c2ccc(B(O)O)c(F)c2)cc1,Train "EU_REACH: 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine",,90213-66-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23997/7/4/2/?documentUUID=d5629ab6-754b-43cb-a869-2ac87cffaa23,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CNC2=C1C(=NC(=N2)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/14116871,PubChem,Clc1nc(Cl)c2cc[nH]c2n1,Train "EU_REACH: 2-[(1E)-2-{3,3'-dichloro-4'-[(1E)-2-[2-oxo-1-(phenylcarbamoyl)propyl]diazen-1-yl]-[1,1'-biphenyl]-4-yl}diazen-1-yl]-3-oxo-N-phenylbutanamide; 2-[(1E)-2-{3,3'-dichloro-4'-[(1E)-2-{1-[(4-methoxyphenyl)carbamoyl]-2-oxopropyl}diazen-1-yl]-[1,1'-biphenyl]-4-yl}diazen-1-yl]-3-oxo-N-phenylbutanamide; 2-[(1E)-2-{3,3'-dichloro-4'-[(1E)-2-{1-[(4-methoxyphenyl)carbamoyl]-2-oxopropyl}diazen-1-yl]-[1,1'-biphenyl]-4-yl}diazen-1-yl]-N-(4-methoxyphenyl)-3-oxobutanamide",,90268-23-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10971/7/4/2/?documentUUID=cd922afa-38f6-4b83-a755-ac6ff2fb8869,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC=CC=C1)N=NC2=C(C=C(C=C2)C3=CC(=C(C=C3)N=NC(C(=O)C)C(=O)NC4=CC=C(C=C4)OC)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/91316050,PubChem,COc1ccc(NC(=O)C(N=Nc2ccc(-c3ccc(N=NC(C(C)=O)C(=O)Nc4ccccc4)c(Cl)c3)cc2Cl)C(C)=O)cc1,Train "EU_REACH: 2-[(1E)-2-{3,3'-dichloro-4'-[(1E)-2-{1-[(2,4-dimethylphenyl)carbamoyl]-2-oxopropyl}diazen-1-yl]-[1,1'-biphenyl]-4-yl}diazen-1-yl]-N-(2,4-dimethylphenyl)-3-oxobutanamide; N-(4-chloro-2,5-dimethoxyphenyl)-2-[(1E)-2-{3,3'-dichloro-4'-[(1E)-2-{1-[(2,4-dimethylphenyl)carbamoyl]-2-oxopropyl}diazen-1-yl]-[1,1'-biphenyl]-4-yl}diazen-1-yl]-3-oxobutanamide; N-(4-chloro-2,5-dimethoxyphenyl)-2-[(1E)-2-{3,3'-dichloro-4'-[(1E)-2-{1-[(4-chloro-2,5-dimethoxyphenyl)carbamoyl]-2-oxopropyl}diazen-1-yl]-[1,1'-biphenyl]-4-yl}diazen-1-yl]-3-oxobutanamide",,90268-24-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2009/7/4/2/?documentUUID=040c07de-35ab-4655-a042-26dc7e7c7290,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)NC(=O)C(C(=O)C)N=NC2=C(C=C(C=C2)C3=CC(=C(C=C3)N=NC(C(=O)C)C(=O)NC4=CC(=C(C=C4OC)Cl)OC)Cl)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/44153097,PubChem,COc1cc(NC(=O)C(N=Nc2ccc(-c3ccc(N=NC(C(C)=O)C(=O)Nc4ccc(C)cc4C)c(Cl)c3)cc2Cl)C(C)=O)c(OC)cc1Cl,Train "JP_CHRIP: 1-(N-Phenylamino)naphthalene","JP_CHRIP: N-(1-Naphthyl)aniline N-Phenyl-alpha-naphthylamine",90-30-2,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0060e.html,"JP_CHRIP: In a test with rabbits (US FDA standard), a slight positive reaction was observed in three out of six animals, and it was judged as a very slight irritant (CICAD 9 (1998)), and in another test with rabbits (OECD TG 404), slight erythema and edema were found in one out of three animals 1 hour after removal of the patch, but these disappeared after 24 or 72 hours, and it was judged to be not a skin irritant (CICAD 9 (1998)). Therefore, it was classified as ""Not classified.""",Provided,JP_CHRIP,1,N(c1ccccc1)c1cccc2ccccc12,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.913F,J-GLOBAL,c1ccc(Nc2cccc3ccccc23)cc1,Train "NZ_CCID: Polyethylene glycol tridecyl ether phosphate","NZ_CCID: PEG-10 Tridecyl ether phosphate, PEG-3 Tridecyl ether phosphate, PEG-6 Tridecyl ether phosphate, Phosphoric acid, (ethoxylated tridecyl alcohol) esters, Poly(oxy-1,2-ethanediyl), .alpha.-tridecyl-.omega.-hydroxy-, phosphate, Poly(oxy-1,2-ethanediyl), alpha-tridecyl-omega-hydroxy-, phosphate, Polyethylene glycol 300 tridecyl ether phosphate, Polyethylene glycol 500 tridecyl ether phosphate, Polyoxyethylene (10) tridecyl ether phosphate, Polyoxyethylene (3) tridecyl ether phosphate, Polyoxyethylene (6) tridecyl ether phosphate, Trideceth-10 phosphate, Trideceth-3 phosphate, Trideceth-6 phosphate, Tridecyl alcohol, ethoxylated, phosphated",9046-01-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E12FB0D7-8C02-4E08-AFC3-21B9257DA8D0,"NZ_CCID: Skin Irritation R-PHRASE: R 35. [MSDS] Eye Irritation SPECIES: RESULT: Strong caustic effect. REFERENCE SOURCE: MSDS.",,NZ_CCID,1,CCCCCCCCCCCCCOCCOP(=O)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/20849296,PubChem,CCCCCCCCCCCCCOCCOP(=O)(O)O,Train "AU_HCIS: Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-(2-aminomethylethyl)-.omega.-(2-aminomethylethoxy)- NZ_CCID: Diaminopolypropylene glycol","NZ_CCID: Ablebond 342-1 Hardener, D 2000, D 230, DA 500, DA 500 (polyoxyalkylene), Etherdiamine MG 420, Jeffamine 2000 Jeffamine 2000, Jeffamine 400, Jeffamine D 1000, Jeffamine D 2000, Jeffamine D 230, Jeffamine D 3000, Jeffamine D 400, Jeffamine D 4000, Jeffamine D 600, Jeffamine D 800, Jeffamine TA 345, MG 420, PC Amine DA 2000, POPDA, Poly(oxy(methyl-1,2-ethanediyl)), alpha-(2-aminomethylethyl)-omega-(2-aminomethylethoxy)-, Poly(oxypropylene)diamine, Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-(2-aminomethylethyl)-.omega.-(2-aminomethylethoxy)-, Polypropylene glycol bis(2-aminopropyl) ether, Polypropylene glycol bis(aminopropyl) ether, TS 64, XNH 3351, alpha,omega-Diaminopolypropylene glycol, alpha-(2-Aminomethylethyl)-omega-(2-aminomethylethoxy)poly(oxy(methyl-1,2-ethanediyl))",9046-10-0,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5188 NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C860790B-DF74-4EC5-817A-0011FBDF6625","NZ_CCID: Skin Irritation REMARK: Classification based on pH level. pH =11.7 (5% solution)[ MSDSs from Google] Eye Irritation REMARK: Classification based on pH level. pH =11.7 (5% solution)[ MSDSs from Google]",,"AU_HCIS, NZ_CCID",2,C1[C@@H]([C@H](CN1)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/146198,PubChem,O[C@H]1CNC[C@@H]1O,Train "EU_REACH: 12,12-bis[(2-hydroxypropoxy)methyl]-5,8,16,19-tetramethyl-4,7,10,14,17,20-hexaoxatricosane-2,22-diol; 12-[(2-hydroxypropoxy)methyl]-12-{[2-(2-hydroxypropoxy)propoxy]methyl}-5,8,16-trimethyl-4,7,10,14,17-pentaoxaicosane-2,19-diol; 9,9-bis({[2-(2-hydroxypropoxy)propoxy]methyl})-5,13-dimethyl-4,7,11,14-tetraoxaheptadecane-2,16-diol",,9051-49-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14284/7/4/2/?documentUUID=28bd8e44-3450-4289-8a15-5c9c3070c90b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CO)COCC(COCCCO)(COCCCO)COCCCO,https://pubchem.ncbi.nlm.nih.gov/compound/165768,PubChem,OCCCOCC(COCCCO)(COCCCO)COCCCO,Train "EU_REACH: (3-Fluor-4'-propyl[1,1'-biphenyl]-4-yl)-boric acid",,909709-42-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27737/7/4/2/?documentUUID=413fc396-9b0d-41d5-bb4c-9c6d517f8a01,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,B(C1=C(C=C(C=C1)C2=CC=C(C=C2)CCC)F)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/53402576,PubChem,CCCc1ccc(-c2ccc(B(O)O)c(F)c2)cc1,Train "EU_REACH: 4-[(4,6-bis{[3-(diethylamino)propyl]amino}-1,3,5-triazin-2-yl)amino]-N-[2-(4,5,6,7-tetrachloro-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)quinolin-8-yl]benzenesulfonamide",,909782-35-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6459/7/4/2/?documentUUID=126a468e-4b27-499e-bd29-619bb406c2d3,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN(CC)CCCNC1=NC(=NC(=N1)NC2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC4=C3N=C(C=C4)C5C(=O)C6=C(C5=O)C(=C(C(=C6Cl)Cl)Cl)Cl)NCCCN(CC)CC,https://pubchem.ncbi.nlm.nih.gov/compound/102171486,PubChem,CCN(CC)CCCNc1nc(NCCCN(CC)CC)nc(Nc2ccc(S(=O)(=O)Nc3cccc4ccc(C5C(=O)c6c(Cl)c(Cl)c(Cl)c(Cl)c6C5=O)nc34)cc2)n1,Train "EU_REACH: ethyl 2-({[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]amino}sulfonyl)benzoate",,90982-32-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23804/7/4/2/?documentUUID=88b55d42-7574-49aa-bd9a-369def13562a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1=CC=CC=C1S(=O)(=O)NC(=O)NC2=NC(=CC(=N2)Cl)OC,https://pubchem.ncbi.nlm.nih.gov/compound/56160,PubChem,CCOC(=O)c1ccccc1S(=O)(=O)NC(=O)Nc1nc(Cl)cc(OC)n1,Train "NZ_CCID: Diphenylmethyl chloride","NZ_CCID: chlorodiphenylmethane",90-99-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/720E9977-DB7F-415D-8358-23F4DDED9B98,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)C(C2=CC=CC=C2)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7035,PubChem,ClC(c1ccccc1)c1ccccc1,Train "EU_REACH: 1,2-dimethoxybenzene",,91-16-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11095/7/4/2/?documentUUID=3b616d4e-530b-4ad3-84a8-6967a57a0e74,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC=CC=C1OC,https://pubchem.ncbi.nlm.nih.gov/compound/7043,PubChem,COc1ccccc1OC,Train "KR_NCIS: N,N-Bis(2-ethylhexyl)-[(1,2,4-triazol-1-yl)methyl] amine NZ_CCID: 1H-1,2,4-Triazole-1-methanamine, N,N-bis(2-ethylhexyl)-","KR_NCIS: 1-(N,N-bis(2-ethylhexyl)aminomethyl)-1,2,4-triazole; 1H-1,2,4-Triazole-1-methanamine, N,N-bis(2-ethylhexyl)-; 2-Ethyl-N-(2-ethylhexyl)-N-(1,2,4-triazol-1-ylmethyl)hexan-1-amine; Bis(2-ethylhexyl)(1H-1,2,4-triazol-1-ylmethyl)amine; N,N-Bis(2-ethylhexyl)-((1,2,4-triazol-1-yl)methyl)amine; N,N-Bis(2-ethylhexyl)-[(1,2,4-triazol-1-yl)methyl]amine; N,N-Bis(2-ethylhexyl)-1,2,4-triazol-1-ylmethanamine; N,N-Bis(2-ethylhexyl)-1H-[(1,2,4-triazol-1-yl)methyl]amine NZ_CCID: N,N-Bis(2-ethylhexyl)-((124-triazol-1-yl)methyl)amine",91273-04-0,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0963A0F7-04A0-4761-9CB0-E045AC83F50A","NZ_CCID: Skin Irritation R-PHRASE: R 34. [ECB] Eye Irritation R-PHRASE: R 34. [ECB]",,"KR_NCIS, NZ_CCID",2,CCCCC(CC)CN(CC(CC)CCCC)CN1C=NC=N1,https://pubchem.ncbi.nlm.nih.gov/compound/163595,PubChem,CCCCC(CC)CN(CC(CC)CCCC)Cn1cncn1,Train "EU_REACH: (3S)-3-[4-(2-chloro-5-iodobenzoyl)phenoxy]oxolane",,915095-87-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5737/7/4/2/?documentUUID=5eb9db26-5b55-44da-9df0-6b3fe34f9c4a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1COC[C@H]1OC2=CC=C(C=C2)C(=O)C3=C(C=CC(=C3)I)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/59423635,PubChem,O=C(c1ccc(O[C@H]2CCOC2)cc1)c1cc(I)ccc1Cl,Train "EU_REACH: 1-bromo-4-(trans-4-ethylcyclohexyl)benzene",,91538-82-8,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22818/7/4/2/?documentUUID=f45a9d05-7ab6-46d9-b380-71b8bd3b65ad,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1CCC(CC1)C2=CC=C(C=C2)Br,https://pubchem.ncbi.nlm.nih.gov/compound/13548369,PubChem,CCC1CCC(c2ccc(Br)cc2)CC1,Train "EU_REACH: [(3S,4R,4aR,6S,6aS,12R,12aS,12bS)-3-(cyclopropanecarbonyloxy)-6,12-dihydroxy-4,6a,12btrimethyl-11-oxo-9-(pyridin-3-yl)-1,2,3,4,4a,5,6,6a,12a,12b-decahydro-11H,12Hbenzo[f]pyrano[4,3-b]chromen-4-yl]methylcyclopropanecarboxylate",,915972-17-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21194/7/4/2/?documentUUID=b1318d1c-2e94-4f82-90d0-54a822ec62ff,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@]12CC[C@@H]([C@@]([C@@H]1C[C@@H]([C@@]3([C@@H]2[C@H](C4=C(O3)C=C(OC4=O)C5=CN=CC=C5)O)C)O)(C)COC(=O)C6CC6)OC(=O)C7CC7,https://pubchem.ncbi.nlm.nih.gov/compound/54589430,PubChem,C[C@]1(COC(=O)C2CC2)[C@@H]2C[C@H](O)[C@@]3(C)Oc4cc(-c5cccnc5)oc(=O)c4[C@H](O)[C@@H]3[C@@]2(C)CC[C@@H]1OC(=O)C1CC1,Train "EU_REACH: 2,2-bis(hydroxymethyl)propane-1,3-diol; 3-(prop-2-en-1-yloxy)prop-1-ene",,91648-24-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25548/7/4/2/?documentUUID=754a2c00-1ac8-4020-a214-dbe82a14d994,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CCOCC(CO)(CO)CO,https://pubchem.ncbi.nlm.nih.gov/compound/3086330,PubChem,C=CCOCC(CO)(CO)CO,Train "JP_CHRIP: N,N-Diethylaniline","JP_CHRIP: (Diethylamino)benzene Phenyldiethylamine",91-66-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0189e.html,"JP_CHRIP: Based on a result of ""slightly irritating"" in a rabbit test (OECD TG404) (IUCLID (2000)), the substance was classified as ""Not classified"".",Provided,JP_CHRIP,1,CCN(CC)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.559I,J-GLOBAL,CCN(CC)c1ccccc1,Train "KR_NCIS: Branched 2-nonylphenol","KR_NCIS: Phenol, 2-nonyl-, branched",91672-41-2,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCCC[C@H](CCC)CC1=CC=CC=C1O,https://pubchem.ncbi.nlm.nih.gov/compound/5748802,PubChem,CCCC[C@H](CCC)Cc1ccccc1O,Train "EU_REACH: [diamino(sulfanylidene)-λ⁵-phosphanyl](propyl)amine",,916809-14-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27049/7/4/2/?documentUUID=fb737627-2371-42c6-a48c-96b05b168be4,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCNP(=S)(N)N,https://pubchem.ncbi.nlm.nih.gov/compound/56623889,PubChem,CCCNP(N)(N)=S,Train "EU_REACH: Sorbitan, octanoate (2:3)",,91844-53-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11460/7/4/2/?documentUUID=37f98b1a-d7d7-4ba7-87fb-06820b918240,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCC(=O)OC([C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/87090353,PubChem,CCCCCCCC(=O)OC(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO,Train "EU_REACH: N-(3-{5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide",,918504-27-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31792/7/4/2/?documentUUID=4b696952-d29c-40b1-bd40-1a67d4ce1795,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)Br)F,https://pubchem.ncbi.nlm.nih.gov/compound/11984556,PubChem,CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Br)cc23)c1F,Train "JP_CHRIP: 3-aminopropyltriethoxysilane NZ_CCID: 3-(Triethoxysilyl) propylamine","JP_CHRIP: 3-(triethoxysilyl)propylamine 3-aminopropyltriethoxysilane NZ_CCID: 3-aminopropyltriethoxysilane",919-30-2,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0056e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/23D4D724-8BF2-4AF3-853A-123015B1918E","JP_CHRIP: In the rabbits tests, alopecia, ulceration, and necrosis were observed. In addition, ecchymosis and moderate to severe edemas, though these symptoms were reversible, were observed (SIDS, accessed in July 2008). Since these observations indicate serious skin corrosion, the substance was classified into Category 1. Since no Draize score is available, refined classification within Category 1 is not available. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CCO[Si](CCCN)(OCC)OCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J14.168B,J-GLOBAL,CCO[Si](CCCN)(OCC)OCC,Train "EU_REACH: 3,3'-dimethylbiphenyl-4,4'-diyl diisocyanate",,91-97-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10067/7/4/2/?documentUUID=1f10555c-f059-4e46-b842-43173d62f3cc,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=CC(=C1)C2=CC(=C(C=C2)N=C=O)C)N=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/7072,PubChem,Cc1cc(-c2ccc(N=C=O)c(C)c2)ccc1N=C=O,Train "NZ_CCID: 1,1,1,3,3,3-Hexafluoro-2-propanol",,920-66-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/98B40B7B-AEA3-4A73-B306-AB5A83189482,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(C(F)(F)F)(C(F)(F)F)O,https://pubchem.ncbi.nlm.nih.gov/compound/13529,PubChem,OC(C(F)(F)F)C(F)(F)F,Train "NZ_CCID: 1,1,3-Trichloroacetone",,921-03-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3BEDD587-C0DA-4CE6-8F9E-C9FE3AC5BCC1,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C(C(=O)C(Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/13530,PubChem,O=C(CCl)C(Cl)Cl,Train "EU_REACH: N-(2-methoxyphenyl)-3-oxobutanamide",,92-15-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14534/7/4/2/?documentUUID=63a12323-4776-41b3-bef5-beeda1e92ece,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)CC(=O)NC1=CC=CC=C1OC,https://pubchem.ncbi.nlm.nih.gov/compound/7078,PubChem,COc1ccccc1NC(=O)CC(C)=O,Train "EU_REACH: Bis[2-(2-ethoxyethoxy)ethyl] cyclohexane-1,4-dicarboxylate",,922165-31-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6167/7/4/2/?documentUUID=d9258c40-4fb8-420e-9ab1-490dcad7407e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOCCOCCOC(=O)C1CCC(CC1)C(=O)OCCOCCOCC,https://pubchem.ncbi.nlm.nih.gov/compound/25116113,PubChem,CCOCCOCCOC(=O)C1CCC(C(=O)OCCOCCOCC)CC1,Train "EU_REACH: 4-trans-Pentyl-4'-trans-propyl-[1,1'-bicyclohexyl]",,92263-41-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27713/7/4/2/?documentUUID=bbc8510b-71a5-4dc1-a144-783658717c85,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCC1CCC(CC1)C2CCC(CC2)CCC,https://pubchem.ncbi.nlm.nih.gov/compound/21972079,PubChem,CCCCCC1CCC(C2CCC(CCC)CC2)CC1,Train "EU_REACH: methyl 3-methylbut-2-enoate",,924-50-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10290/7/4/2/?documentUUID=f2ba5bc9-2c4d-4dcf-938b-41c25c3a2c49,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=CC(=O)OC)C,https://pubchem.ncbi.nlm.nih.gov/compound/13546,PubChem,COC(=O)C=C(C)C,Train "EU_REACH: diisopropyl succinate",,924-88-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13751/7/4/2/?documentUUID=af7d3d87-f3b7-4929-8ad3-465f079f7f6a,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)OC(=O)CCC(=O)OC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/70213,PubChem,CC(C)OC(=O)CCC(=O)OC(C)C,Train "NZ_CCID: Phenylpiperazine","NZ_CCID: 1-phenylpiperazine, N-Phenylpiperazine",92-54-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8697F25C-3221-4E41-A7A7-6537CFFF735B,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CN(CCN1)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/7096,PubChem,c1ccc(N2CCNCC2)cc1,Train "EU_REACH: 2-methyl-4-phenylpentan-1-ol",,92585-24-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/9865/7/4/2/?documentUUID=f1a07cda-93e5-47b8-aaad-1db0ff4a14ee,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CC(C)C1=CC=CC=C1)CO,https://pubchem.ncbi.nlm.nih.gov/compound/3021997,PubChem,CC(CO)CC(C)c1ccccc1,Train "NZ_CCID: 2-(2-Aminoethoxy) ethanol","NZ_CCID: diglycolamine",929-06-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A095839C-3161-4CAA-8FDF-26242B49A75B,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(COCCO)N,https://pubchem.ncbi.nlm.nih.gov/compound/13578,PubChem,NCCOCCO,Train "NZ_CCID: Triethylene glycol diamine",,929-59-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B4945A60-AAC8-4C2B-8EDF-9A96AD9D6D7D,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C(COCCOCCN)N,https://pubchem.ncbi.nlm.nih.gov/compound/70248,PubChem,NCCOCCOCCN,Train "NZ_CCID: 4-Amino-N,N-diethylaniline","NZ_CCID: N,N-Diethyl-1,4-phenylenediamine",93-05-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D9646130-1F87-4B82-AF88-1D885B828532,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCN(CC)C1=CC=C(C=C1)N,https://pubchem.ncbi.nlm.nih.gov/compound/7120,PubChem,CCN(CC)c1ccc(N)cc1,Train "NZ_CCID: 2-Naphthalenesulphonyl chloride",,93-11-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4BD91437-1AF4-4D57-B1DF-BD98B679AED9,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7125,PubChem,O=S(=O)(Cl)c1ccc2ccccc2c1,Train "EU_REACH: [(2-methoxyphenyl)amino]methanesulfonic acid",,93-13-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17353/7/4/2/?documentUUID=1980edaf-8b4e-49a4-a123-88bfde81d7fa,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC=CC=C1NCS(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/7126,PubChem,COc1ccccc1NCS(=O)(=O)O,Train "NZ_CCID: 2-Methylbenzoyl chloride","NZ_CCID: o-toluoyl chloride",933-88-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CDEA65B6-2284-461E-A98A-D1F6B56CB1FD,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC1=CC=CC=C1C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/70276,PubChem,Cc1ccccc1C(=O)Cl,Train "EU_REACH: N,N'-Di-sec-butyl-1,1-dimethylsilanediamine",,93777-98-1,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23717/7/4/2/?documentUUID=b86d1fe8-11bb-4fa5-867b-aac89691f0be,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C)N[Si](C)(C)NC(C)CC,https://pubchem.ncbi.nlm.nih.gov/compound/16205771,PubChem,CCC(C)N[Si](C)(C)NC(C)CC,Train "EU_REACH: 2-decyltetradecanoic acid",,93778-52-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18880/7/4/2/?documentUUID=94996dc2-25f1-48c4-b645-62a8a330f8e1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCC(CCCCCCCCCC)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/175556,PubChem,CCCCCCCCCCCCC(CCCCCCCCCC)C(=O)O,Train "EU_REACH: 2-octyldodecyl 3-methylheptadecanoate",,93803-87-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10874/7/4/2/?documentUUID=0c50fc58-8a28-4be4-bd24-68800b7cbf22,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCC(CCCCCCCC)COC(=O)CCCCCCCCCCCCCCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/44147658,PubChem,CCCCCCCCCCC(CCCCCCCC)COC(=O)CCCCCCCCCCCCCCC(C)C,Train "EU_REACH: N-(4-carbamoylphenyl)-4-methoxy-3-nitrobenzamide",,93839-20-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5382/7/4/2/?documentUUID=1971445a-d177-43c4-804d-616fc1761b0f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=C(C=C(C=C1)C(=O)NC2=CC=C(C=C2)C(=O)N)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/874576,PubChem,COc1ccc(C(=O)Nc2ccc(C(N)=O)cc2)cc1[N+](=O)[O-],Train "EU_REACH: N-(4-carbamoylphenyl)-4-nitrobenzamide",,93839-21-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5404/7/4/2/?documentUUID=7bccd3e7-2a40-4f41-9b75-a13115a6a96b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1C(=O)N)NC(=O)C2=CC=C(C=C2)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/689161,PubChem,NC(=O)c1ccc(NC(=O)c2ccc([N+](=O)[O-])cc2)cc1,Train "EU_REACH: 5-nitro-1,3-dihydro-2H-benzimidazol-2-one",,93-84-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1875/7/4/2/?documentUUID=f23e7883-f4ff-46eb-a073-90b6306043a5,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC2=C(C=C1[N+](=O)[O-])NC(=O)N2,https://pubchem.ncbi.nlm.nih.gov/compound/3725611,PubChem,O=c1[nH]c2ccc([N+](=O)[O-])cc2[nH]1,Train "EU_REACH: (2E)-3-methyl-5-phenylpent-2-enenitrile",,93893-89-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20910/7/4/2/?documentUUID=42fa25c8-63d2-4f0b-bcc0-1ec59b8d7559,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C/C(=C\C#N)/CCC1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/1585264,PubChem,C/C(=C\C#N)CCc1ccccc1,Train "EU_REACH: 3-[(3-{[(2-cyanoethyl)amino]methyl}-3,5,5-trimethylcyclohexyl)amino]propanenitrile",,93940-97-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27660/7/4/2/?documentUUID=74ba3518-30f8-4abc-8531-4cca642df503,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(CC(CC(C1)(C)CNCCC#N)NCCC#N)C,https://pubchem.ncbi.nlm.nih.gov/compound/3022992,PubChem,CC1(C)CC(NCCC#N)CC(C)(CNCCC#N)C1,Train "EU_REACH: ethyl benzoylacetate",,94-02-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33015/7/4/2/?documentUUID=61b95e60-f5f3-4e33-b278-3027ce1f8ab0,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)CC(=O)C1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/7170,PubChem,CCOC(=O)CC(=O)c1ccccc1,Train "JP_CHRIP: Propyl 4-hydroxybenzoate",,94-13-3,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0062e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 3) (equivalent to OECD TG 404, semi-occlusive, 4-hour application, 7-day observation), no erythema or edema was seen in any animal (erythema/eschar score: 0/0/0, edema score: 0/0/0) (REACH registration dossier (Accessed Oct. 2020)).",Provided,JP_CHRIP,1,CCCOC(=O)c1ccc(O)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.943H,J-GLOBAL,CCCOC(=O)c1ccc(O)cc1,Train "EU_REACH: 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol",,94361-06-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32337/7/4/2/?documentUUID=75ec2bab-864c-4886-8b06-cb9c17b5cc50,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C1CC1)C(CN2C=NC=N2)(C3=CC=C(C=C3)Cl)O,https://pubchem.ncbi.nlm.nih.gov/compound/86132,PubChem,CC(C1CC1)C(O)(Cn1cncn1)c1ccc(Cl)cc1,Train "EU_REACH: 2-(benzoyloxy)ethyl benzoate",,94-49-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22707/7/4/2/?documentUUID=579d34e7-ad34-4624-8d1a-d3ebc1ab1110,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C(=O)OCCOC(=O)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/66750,PubChem,O=C(OCCOC(=O)c1ccccc1)c1ccccc1,Train "JP_CHRIP: [Methyl(oxo){1-[6-(trifluoromethyl)-3-pyridyl]ethyl}-lambda(6)-sulfanylidene]carbamonitrile; Sulfoxaflor",,946578-00-3,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-0001e.html,"JP_CHRIP: [Rationale for the Classification] It was classified as ""Not classified"" from (1) - (3). [Evidence Data] (1) In a skin irritation test with rabbits according to OECD TG 404, the mean score at 24/48/72 hours was all < 2.3, and all signs disappeared after 72 hours (EU CLP CLH (2013), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2016)). (2) This substance was not irritating to the skin and eye of rabbits (JMPR (2011), HSDB (Access on April 2020)). (3) This substance caused only mild skin irritation in rabbits with minimal erythema and edema seen at 1 but not at 24 hours post-application (ACGIH (7th, 2019)).",Provided,JP_CHRIP,1,CC(c1ccc(nc1)C(F)(F)F)[S+](=NC#N)(C)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.920.636H,J-GLOBAL,CC(c1ccc(C(F)(F)F)nc1)[S+](C)([O-])=NC#N,Train "JP_CHRIP: Dodecane-12-lactam","JP_CHRIP: 12-dodecanelactam lauryl lactam",947-04-6,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-0017e.html,"JP_CHRIP: It was classified as ""Not classified"" because it was assessed to be not irritating in a 4-hour application test with rabbits (OECD TG 404) in SIDS (2005).",Provided,JP_CHRIP,1,O=C1CCCCCCCCCCCN1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J12.504K,J-GLOBAL,O=C1CCCCCCCCCCCN1,Train "EU_REACH: diphenylsilanediol",,947-42-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17717/7/4/2/?documentUUID=dc859229-062f-40f4-a70c-ec5f5a1d99ed,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)[Si](C2=CC=CC=C2)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/13693,PubChem,O[Si](O)(c1ccccc1)c1ccccc1,Train "EU_REACH: α,α'-propylenedinitrilodi-o-cresol",,94-91-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5314/7/4/2/?documentUUID=8552fa04-76b1-4821-a605-b8c8354e8115,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CN=CC1=CC=CC=C1O)N=CC2=CC=CC=C2O,https://pubchem.ncbi.nlm.nih.gov/compound/7210,PubChem,CC(CN=Cc1ccccc1O)N=Cc1ccccc1O,Train "EU_REACH: ethyl 3-{5-[(3-chloro-2-fluorophenyl)methyl]-2,4-dimethoxyphenyl}-3-oxopropanoate",,949465-81-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18428/7/4/2/?documentUUID=300c2e38-e1e7-4097-8bdd-0386a1a50164,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)CC(=O)C1=C(C=C(C(=C1)CC2=C(C(=CC=C2)Cl)F)OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/24809654,PubChem,CCOC(=O)CC(=O)c1cc(Cc2cccc(Cl)c2F)c(OC)cc1OC,Train "EU_REACH: ethyl 6-(3-chloro-2-fluorobenzyl)-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate",,949465-91-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18431/7/4/2/?documentUUID=20ee60e5-6446-4c3e-87a1-1f53967c609f,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1=CN(C2=C(C1=O)C=C(C(=C2)OC)CC3=C(C(=CC=C3)Cl)F)[C@H](CO)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/24803354,PubChem,CCOC(=O)c1cn([C@H](CO)C(C)C)c2cc(OC)c(Cc3cccc(Cl)c3F)cc2c1=O,Train "EU_REACH: 2,4-dichloro-1-(chloromethyl)benzene",,94-99-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17874/7/4/2/?documentUUID=ad741764-0c14-4966-aa55-eb75df3d0ec1,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C=C1Cl)Cl)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/7212,PubChem,ClCc1ccc(Cl)cc1Cl,Train "EU_REACH: 5-amino-1,3-dihydro-2H-benzimidazol-2-one",,95-23-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1949/7/4/2/?documentUUID=9caeb93f-64b0-424a-a6b3-f186fa26a87d,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC2=C(C=C1N)NC(=O)N2,https://pubchem.ncbi.nlm.nih.gov/compound/66765,PubChem,Nc1ccc2[nH]c(=O)[nH]c2c1,Train "NZ_CCID: 1H-Imidazole-1-ethanol, 2-(8-heptadecenyl)-4,5-dihydro-",,95-38-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3ED1723E-58E9-4675-8AC9-EAE5A25FC92E,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCCCCCCC/C=C/CCCCCCCC1=NCCN1CCO,https://pubchem.ncbi.nlm.nih.gov/compound/5367893,PubChem,CCCCCCCC/C=C/CCCCCCCC1=NCCN1CCO,Train "AU_HCIS: o-cresol [1] JP_CHRIP: o-Cresol KR_NCIS: 2-Methylphenol NZ_CCID: 2-Cresol US_HSDB: o-CRESOL","AU_HCIS: o-cresol [2] p-cresol [3] mix-cresol [4] Phenol, 2-methyl- o-cresol p-cresol mix-cresol JP_CHRIP: 2-Hydroxy-1-methylbenzene 2-Methylphenol o-Cresol; 2-Methylphenol ortho-Hydroxytoluene Phenol, 2-methyl- KR_NCIS: 1-Hydroxy-2-methylbenzene; 1-Methyl-2-hydroxybenzene; 2-Hydroxy-1-methylbenzene; CRESOL, ORTHO; o-Cresol; O-CRESYLIC ACID; o-Hydroxytoluene; ORTHO-CRESOL; Phenol, 2-methyl- NZ_CCID: o-Cresol",95-48-7,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1067 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2032e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F12DC57A-0908-4829-BA1D-A6C6510C1CBF US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1813","JP_CHRIP: There are several reports that severe irritation or corrosivity was observed in tests in which this substance was applied to the skin of rabbits (EHC 168 (1995), Initial Risk Assessment Report (NITE, CERI, NEDO, 2007), PATTY (6th, 2012)). In addition, there is a description that this substance showed corrosivity to the skin (SIDS (2001), Environmental Risk Assessment for Chemical Substances Vol. 5 (Ministry of the Environment, 2006)). From the above, it was classified in Category 1. Besides, this substance was classified in ""C; R34"" in EU DSD classification and in ""H314 Skin Corr. 1B"" in EU CLP classification. NZ_CCID: Skin Irritation R-PHRASE: R 34. [Company data] Eye Irritation R-PHRASE: R 34. [Company data]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,Cc1ccccc1O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.176B,J-GLOBAL,Cc1ccccc1O,Train "EU_REACH: 1-chloro-2-methylbenzene JP_CHRIP: o-Chlorotoluene","JP_CHRIP: 1-Chloro-2-methylbenzene 2-chlorotoluene Benzene, 1-chloro-2-methyl- o-Tolyl chloride",95-49-8,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13832/7/4/2/?documentUUID=d79909c7-c95a-459e-a44a-0594f258f5c8 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2026e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: There is a report that in a skin irritation test (OECD TG 404) with rabbits, erythema was observed after 4-hour application but disappeared later (SIDS (2004), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). Besides, in multiple tests in which this substance was applied for 24 hours, although moderate edema, severe erythema and necrosis, etc. were observed, and moderate desquamation, thickening at the application site, exfoliation and scarring were observed 1 week after administration (SIDS (2004), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), it was judged to be mild irritation in the OECD-compliant test, therefore, it was classified as ""Not classified"" (Category 3 in UN GHS classification). The category was changed according to the revised guideline.",Provided,"EU_REACH, JP_CHRIP",2,Cc1ccccc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.564E,J-GLOBAL,Cc1ccccc1Cl,Train "JP_CHRIP: o-Chloroaniline","JP_CHRIP: 1-Amino-2-chlorobenzene 2-Chloroaminobenzene Benzenamine, 2-chloro- Fast yellow GC base",95-51-2,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-meti-0005e.html,"JP_CHRIP: In a skin irritation test using rabbits (OECD TG 404), there is a report that application of 0.1 mL of this substance resulted in no irritation (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), BUA 57 (1991)). Therefore, it was classified as ""Not classified.""",Provided,JP_CHRIP,1,Nc1ccccc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.952G,J-GLOBAL,Nc1ccccc1Cl,Train "EU_REACH: benzene-1,2-diamine JP_CHRIP: o-Phenylenediamine","JP_CHRIP: o-Phenylenediamine 1,2-Benzenediamine 1,2-Phenylenediamine 2-Aminoaniline o-Diaminobenzene",95-54-5,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2001/7/4/2/?documentUUID=2817d238-3fe2-4752-a730-e9161ac1f037 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2008e.html","EU_REACH: Experimental study (OECD TG 404, GLP) JP_CHRIP: [Rationale for the Classification] Based on (1) and (2), it was classified as ""Not classified."" [Evidence Data] (1) In a skin irritation test with rabbits according to OECD TG 404, it is reported to show no irritation (DFGOT vol.13 (1999)). (2) It is reported that in a skin irritation test with 3 rabbits according to OECD TG 404, very light erythema was observed after 48 hours. This was reversible after 72 hours, and that the mean scores at 24/48/72 hours for erythema and edema were 0.6 and 0, respectively (REACH registration dossier (Access on June 2019)).",Provided,"EU_REACH, JP_CHRIP",2,Nc1ccccc1N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.954C,J-GLOBAL,Nc1ccccc1N,Train "JP_CHRIP: 2-Chlorophenol","JP_CHRIP: 2-Chloro-1-hydroxybenzene 2-Hydroxychlorobenzene 2-Monochlorophenol o-Chlorophenol Phenol, 2-chloro-",95-57-8,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-meti-0008e.html,"JP_CHRIP: For animals, ""corrosion with severe skin damages such as erythema, dropsy, discoloration, etc.""(ATSDR (1999)) has been described in the direct dosage study to skin of rabbits. For humans, ""concern about occurrence of contact dermatitis"" (HSDB (2005)) has been described. Therefore, it was classified into Category 1.",,JP_CHRIP,1,Oc1ccccc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.566A,J-GLOBAL,Oc1ccccc1Cl,Train "JP_CHRIP: 3,4-xylenol; 3,4-Dimethylphenol KR_NCIS: 3,4-Dimethylphenol NZ_CCID: 3,4-Dimethylphenol","JP_CHRIP: 3,4-Xylenol Phenol, 3,4-dimethyl- KR_NCIS: 1,3,4-Xylenol; 1-Hydroxy-3,4-dimethylbenzene; 3,4-Xylenol; 4,5-Dimethylphenol; 4-Hydroxy-1,2-dimethylbenzene; 4-Hydroxy-o-xylene NZ_CCID: 3,4-xylenol",95-65-8,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2026e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AFACE293-BD6D-498E-83E8-A9E95710D76E","JP_CHRIP: [Rationale for the Classification] Based on (1), it was classified in Category 1. Besides, since new data was obtained, the category was changed. [Evidence Data] (1) A study in guinea pigs reported this substance at doses of 0.25-1 mg/kg, to be severely irritating to the skin, with moderate edema developing within 24 hours, in addition to necrosis and eschar formation (NICNAS IMAP (Access on August 2019)). NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,Cc1ccc(O)cc1C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J43.457D,J-GLOBAL,Cc1ccc(O)cc1C,Train "EU_REACH: 2,4-dimethylaniline",,95-68-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2085/7/4/2/?documentUUID=ea2ae5de-666a-4d65-84b6-8aca18e768a8,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)N)C,https://pubchem.ncbi.nlm.nih.gov/compound/7250,PubChem,Cc1ccc(N)c(C)c1,Train "JP_CHRIP: 3,4-Dichlorotoluene",,95-75-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0049e.html,"JP_CHRIP: Based on the test results as non-irritant after applying 0.5 mL of the test substance for 4 hours on rabbit skin (OECD TG 404) (ECHA (Access on December 2016)), it is classified as ""Not classified.""",Provided,JP_CHRIP,1,Cc1ccc(Cl)c(Cl)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.570J,J-GLOBAL,Cc1ccc(Cl)c(Cl)c1,Train "EU_REACH: 4'-ethyl-3-fluoro-4-(4-propylphenyl)-1,1'-biphenyl",,95759-44-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21014/7/4/2/?documentUUID=1958b2b6-90ab-4e44-8283-74658fd64170,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1=CC=C(C=C1)C2=C(C=C(C=C2)C3=CC=C(C=C3)CC)F,https://pubchem.ncbi.nlm.nih.gov/compound/1715558,PubChem,CCCc1ccc(-c2ccc(-c3ccc(CC)cc3)cc2F)cc1,Train "JP_CHRIP: 3,4-dichloroaniline","JP_CHRIP: 1-Amino-3,4-dichlorobenzene 3,4-Dichlorobenzenamine Benzenamine, 3,4-dichloro-",95-76-1,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-meti-0014e.html,"JP_CHRIP: Since there are descriptions, ""slightly irritating, erythema grade 1, recovery within 2 days"" (EU-RAR (2006), IUCLID (2000)) in the Draize test using rabbits (OECD TG404, GLP) and ""not irritating"" (IUCLID (2000)) in the 24 hour skin irritation test using rabbits, it was classified into ""Not classified"".",Provided,JP_CHRIP,1,Nc1ccc(Cl)c(Cl)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J43.172I,J-GLOBAL,Nc1ccc(Cl)c(Cl)c1,Train "JP_CHRIP: 2,4-Toluenediamine [2,4-diaminotoluene]","JP_CHRIP: 2,4-Diaminotoluene 1,3-Benzenediamine, 4-methyl- 2,4-Diaminotoluene 2,4-TDA 2,4-Toluenediamine 4-methyl-m-phenylenediamine 4-methylphenylene-1,3-diamine",95-80-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0094e.html,"JP_CHRIP: It was reported that in a skin irritation test with rabbits (OECD TG 404), no irritation was observed by the application of this substance (EU-RAR (2008), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). In addition, it is described with no specific details that this substance is irritating to the skin (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008)). From the above, this substance was classified as ""Not classified"" (Category 3 in the UN GHS classification) based on the information of the test following the Test Guideline.",Provided,JP_CHRIP,1,Cc1ccc(N)cc1N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.958F,J-GLOBAL,Cc1ccc(N)cc1N,Train "EU_REACH: 1-[(1R,3S,6S)-2,2,3,6-tetramethylcyclohexyl]hexan-3-ol",,95851-08-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31884/7/4/2/?documentUUID=b8a6a03e-233d-4832-8b62-96c3f5d405b6,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC(CCC1C(CCC(C1(C)C)C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/22326187,PubChem,CCCC(O)CCC1C(C)CCC(C)C1(C)C,Train "JP_CHRIP: 2,5-xylenol; 2,5-Dimethylphenol KR_NCIS: 2,5-Dimethylphenol NZ_CCID: Phenol, 2,5-dimethyl-","JP_CHRIP: 2,5-Xylenol Phenol, 2,5-dimethyl- KR_NCIS: 1,2,5-Xylenol; 1-Hydroxy-2,5-dimethylbenzene; 2,5-Xylenol; 2-Hydroxy-p-xylene; 3,6-Dimethylphenol; 6-Methyl-m-cresol; Hydroxy-p-xylene; Phenol, 2,5-dimethyl-; p-Xylenol",95-87-4,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2027e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D46A5D75-A7A8-4EFA-BE7D-974BDE9D5147","JP_CHRIP: [Rationale for the Classification] Based on (1), (2), it was classified in Category 1. [Evidence Data] (1) In REACH, the read-across approach can be applied to the category of xylenol isomers, and based on the results of 3,5-xylenol, this substance is also regarded as a corrosive substance (REACH registration dossier (Access on July 2019)). (2) It is classified in ""Skin Corr. 1B"" in EU CLP classification (EU CLP classification (Access on July 2019)). NZ_CCID: Skin Irritation R PHRASE: R 34 [NCLASS] Eye Irritation SPECIES: RESULT: Corrosive. REFERENCE SOURCE: [NTP]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,Cc1ccc(C)c(O)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J43.459K,J-GLOBAL,Cc1ccc(C)c(O)c1,Train "JP_CHRIP: 1,2,4,5-Tetrachlorobenzene","JP_CHRIP: Benzene tetrachloride s-Tetrachlorobenzene",95-94-3,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0066e.html,"JP_CHRIP: It was classified as ""Not classified"" because it is reported that no appreciable irritation was observed in a test by a repeated application of a 10% solution to the ear or abdominal skin of rabbits (BUA 86 (1991)), and it is described that this substance was concluded to be non-irritating in a skin irritation test (OECD TG 404) (BUA 86 (1991)).",Provided,JP_CHRIP,1,Clc1cc(Cl)c(Cl)cc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.573D,J-GLOBAL,Clc1cc(Cl)c(Cl)cc1Cl,Train "EU_REACH: 2-[2-(4-methylcyclohex-3-en-1-yl)propyl]cyclopentan-1-one",,95962-14-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30194/7/4/2/?documentUUID=7f54fd88-7be6-467a-87c0-fee4d0f64dab,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CCC(CC1)C(C)CC2CCCC2=O,https://pubchem.ncbi.nlm.nih.gov/compound/175661,PubChem,CC1=CCC(C(C)CC2CCCC2=O)CC1,Train "EU_REACH: methyl 1-(3-chloropyridin-2-yl)-3-(hydroxymethyl)-1H-pyrazole-5-carboxylate",,960316-73-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16970/7/4/2/?documentUUID=c6359ae9-4890-4570-8bf7-f9e4831b0ff7,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1=CC(=NN1C2=C(C=CC=N2)Cl)CO,https://pubchem.ncbi.nlm.nih.gov/compound/53235501,PubChem,COC(=O)c1cc(CO)nn1-c1ncccc1Cl,Train "JP_CHRIP: 1,2,3-Trichloropropane","JP_CHRIP: 1,2,3-Trichloropropane Allyl trichloride Glycerol trichlorohydrin Propane, 1,2,3-trichloro-",96-18-4,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0117e.html,"JP_CHRIP: In a skin irritation test (in conformity to OECD TG 404), in which 0.5 mL of test substance was applied to rabbits for 4 hours, mild skin irritation was observed (SIDS (2004)). Therefore, it was classified as ""Not classified"" (corresponding to Category 3 in UN GHS classification).",Provided,JP_CHRIP,1,ClCC(Cl)CCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.962D,J-GLOBAL,ClCC(Cl)CCl,Train "AU_HCIS: 1-Butanol, 2-amino- NZ_CCID: 2-Amino-1-butanol",,96-20-8,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5539 NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/31824D2E-8478-4F6A-9AED-F1374214E4F6","NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"AU_HCIS, NZ_CCID",2,CCC(CO)N,https://pubchem.ncbi.nlm.nih.gov/compound/22129,PubChem,CCC(N)CO,Train "EU_REACH: 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl 2-chloroprop-2-enoate",,96383-55-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10080/7/4/2/?documentUUID=c618a845-7e18-4373-a433-f6800d8968a4,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=C(C(=O)OCCC(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/59297287,PubChem,C=C(Cl)C(=O)OCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train "EU_REACH: 1,3-dioxolan-2-one",,96-49-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14909/7/4/2/?documentUUID=d8a418a1-a143-4dbb-99f6-8549c99f4f82,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1COC(=O)O1,https://pubchem.ncbi.nlm.nih.gov/compound/7303,PubChem,O=C1OCCO1,Train "EU_REACH: 4-trans-ethyl-4'-trans-propyl-[1,1'-bicyclohexyl]",,96624-41-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27175/7/4/2/?documentUUID=03133f81-119c-437d-965b-e5b7cff42129,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1CCC(CC1)C2CCC(CC2)CC,https://pubchem.ncbi.nlm.nih.gov/compound/19850402,PubChem,CCCC1CCC(C2CCC(CC)CC2)CC1,Train "EU_REACH: 4-trans-Butyl-4'-trans-propyl-[1,1'-bicyclohexyl]",,96624-52-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27171/7/4/2/?documentUUID=7db757dd-d416-4694-8516-85ff88745425,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC1CCC(CC1)C2CCC(CC2)CCC,https://pubchem.ncbi.nlm.nih.gov/compound/11086663,PubChem,CCCCC1CCC(C2CCC(CCC)CC2)CC1,Train "EU_REACH: 3-[benzyl({4-[2-(4-nitrophenyl)diazen-1-yl]phenyl})amino]propanenitrile",,96662-24-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12107/7/4/2/?documentUUID=3df49d34-3273-4803-8110-a8b6d0fd9485,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)CN(CCC#N)C2=CC=C(C=C2)N=NC3=CC=C(C=C3)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/15869329,PubChem,N#CCCN(Cc1ccccc1)c1ccc(N=Nc2ccc([N+](=O)[O-])cc2)cc1,Train "EU_REACH: 4-methyl-3-nitrobenzoic acid",,96-98-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5345/7/4/2/?documentUUID=2c363557-c8ce-4f99-9472-c39aa4748c9b,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)C(=O)O)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/7319,PubChem,Cc1ccc(C(=O)O)cc1[N+](=O)[O-],Train "NZ_CCID: Benzoic acid, 2-hydroxy-5-sulpho-",,97-05-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/002E9059-975E-4234-8FF5-7D6A59A6BBD8,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC(=C(C=C1S(=O)(=O)O)C(=O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/7322,PubChem,O=C(O)c1cc(S(=O)(=O)O)ccc1O,Train "JP_CHRIP: 4-Nitro-o-anisidine","JP_CHRIP: 4-Nitro-o-anisidine",97-52-9,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2017e.html,"JP_CHRIP: Based on a report that in a skin irritation test with rabbits, no irritation was observed in the application of 500 mg of this substance (NTP IMM98007 (2011) (Access on May 2017)), it was classified as ""Not classified."" Besides, there is a description in the information source in List 3 that no irritation tests with rabbits (according to OECD TG 404) (GESTIS (Access on May 2017)).",Provided,JP_CHRIP,1,COc1cc(ccc1N)[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J96.207D,J-GLOBAL,COc1cc([N+](=O)[O-])ccc1N,Train "EU_REACH: 1-(2,5-dioxoimidazolidin-4-yl)urea",,97-59-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13641/7/4/2/?documentUUID=dfbe1428-6ee4-4e73-bbdf-57019e1e6194,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1(C(=O)NC(=O)N1)NC(=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/204,PubChem,NC(=O)NC1NC(=O)NC1=O,Train "NZ_CCID: 2-Methylpentanoic acid",,97-61-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F02F6EDF-E0A6-46F0-AE49-69832589F52D,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCC(C)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/7341,PubChem,CCCC(C)C(=O)O,Train "JP_CHRIP: Isobutyric anhydride NZ_CCID: 2-Methylpropionic anhydride","NZ_CCID: iso-butyric anhydride",97-72-3,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0158e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/166DD4DA-022D-40BA-B0F2-2B797880CE43","JP_CHRIP: The substance is rapidly hydrolyzed to isobutyric acid by contact with water (SIDS (J) (Access on Sep. 2010)). Thus, the substance was classified as Category 1 based on the document that open application of isobutyric acid to rabbit skin caused some necrosis within 24 hours (PATTY, 5th (2001)). NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CC(C)C(=O)OC(=O)C(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J38.161F,J-GLOBAL,CC(C)C(=O)OC(=O)C(C)C,Train "JP_CHRIP: Tetraethylthiuram disulfide (Disulfiram)","JP_CHRIP: 1,1'-Dithiobis(N,N-diethylthioformamide) bis-(N,N-Diethylthiocarbamoyl)disulfide Disulfiram TETD Tetraethylthiuramdisulfide",97-77-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-mhlw-2003e.html,"JP_CHRIP: [Rationale for the Classification] Based on evidence (1)-(4) that this substance is not skin irritating, it was classified as ""Not classified."" [Evidence Data] (1) There is a report that a drunken-like effect was seen due to exposure with workers at a manufacturing plant, but it is also known that skin irritation is generally seen at the time of perspiration, and minimal skin irritation was observed in only 9% of the overall. In addition, exposure concentrations were not determined (ACGIH (7th, 2001)). (2) There is a report that in a skin irritation test (corresponds to OECD TG 404, n=6) with rabbits, when this substance was applied for 4 hours, PII (skin primary irritation index) was 0.13 (maximum 8) (NICNAS IMAP (Accessed Jun. 2018), REACH registration dossier (Accessed Jun. 2018)) (3) There is a report that in a skin irritation test (corresponds to OECD TG 404, GLP-compliant) with rabbits, when this substance was applied for 24 hours, the erythema score was 0.25, but recovery was complete in 3 days, and the edema score was 0 (NICNAS IMAP (Accessed Jun. 2018), REACH registration dossier (Accessed Jun. 2018)). (4) There is a report that in a skin irritation test (corresponds to OECD TG 404, GLP-compliant) with rabbits, when this substance was applied for 24 hours, the erythema score was 0.96, but recovery was complete in 7 days, and the edema score was 0 (NICNAS IMAP (Accessed Jun. 2018), REACH registration dossier (Accessed Jun. 2018)).",Provided,JP_CHRIP,1,CCN(CC)C(=S)SSC(=S)N(CC)CC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.980B,J-GLOBAL,CCN(CC)C(=S)SSC(=S)N(CC)CC,Train "EU_REACH: methyl 2-[[4-ethoxy-6-(methylamino)-1,3,5-triazin-2-yl]carbamoylsulfamoyl]benzoate",,97780-06-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20802/7/4/2/?documentUUID=bb417d49-fab8-41e6-a350-6bd3c59c9602,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC1=NC(=NC(=N1)NC(=O)NS(=O)(=O)C2=CC=CC=C2C(=O)OC)NC,https://pubchem.ncbi.nlm.nih.gov/compound/91756,PubChem,CCOc1nc(NC)nc(NC(=O)NS(=O)(=O)c2ccccc2C(=O)OC)n1,Train "JP_CHRIP: Triethylborane NZ_CCID: Borane, triethyl-","NZ_CCID: Triethylborane, Triethylboron",97-94-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0199e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DA2A3A18-B3F5-4666-AD2A-6C944F6126B4","JP_CHRIP: The substance was classified as Category 1 based on the documents that the substance caused strong irritation to human skin, eye and respiratory system (HSDB (2010)) and the substance was classified as ""C; R34 (Skin Corr. 1B)"" as trialkyboranes in the EU classification (EC-JRC (ESIS) (Access on Dec. 2010)). NZ_CCID: Skin Irritation R-PHRASE: R 34 Causes burns. [N-CLASS] Eye Irritation R-PHRASE: R 34 Causes burns. [N-CLASS]",,"JP_CHRIP, NZ_CCID",2,CCB(CC)CC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J55.478B,J-GLOBAL,CCB(CC)CC,Train "EU_REACH: 2-chloro-1,1-dimethoxyethane",,97-97-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17184/7/4/2/?documentUUID=a82e2414-69a9-4b74-8509-a41746bfe512,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(CCl)OC,https://pubchem.ncbi.nlm.nih.gov/compound/60986,PubChem,COC(CCl)OC,Train "EU_REACH: 2,9-dimethyl-5,7,12,14-tetrahydro-5,12-diazapentacene-7,14-dione",,980-26-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15097/7/4/2/?documentUUID=aabf1b39-4487-4c50-b208-f10146622530,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC2=C(C=C1)NC3=CC4=C(C=C3C2=O)NC5=C(C4=O)C=C(C=C5)C,https://pubchem.ncbi.nlm.nih.gov/compound/70423,PubChem,Cc1ccc2[nH]c3cc4c(=O)c5cc(C)ccc5[nH]c4cc3c(=O)c2c1,Train "JP_CHRIP: Benzenesulfonyl chloride NZ_CCID: Benzenesulphonyl chloride",,98-09-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0094e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/15891980-7B2F-49FA-9776-0F56221A1F4B","JP_CHRIP: Based on a result of ""corrosive"" in a rabbit test (IUCLID (2000)), the substance was classified into Category 1. NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,ClS(=O)(=O)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.983G,J-GLOBAL,O=S(=O)(Cl)c1ccccc1,Train "JP_CHRIP: Benzenesulfonic acid NZ_CCID: Benzenesulphonic acid","JP_CHRIP: Benzenemonosulfonic acid Phenylsulfonic acid",98-11-3,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0071e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E6F359F2-D929-4675-A78E-45582CC9C70B","JP_CHRIP: It was classified in Category 1 because there is a description of severe skin irritation in guinea pigs (HSDB (2002)), and the saturated solution of this substance has pH 2. NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,"JP_CHRIP, NZ_CCID",2,OS(=O)(=O)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J62.182J,J-GLOBAL,O=S(=O)(O)c1ccccc1,Train "JP_CHRIP: Trichlorophenylsilane",,98-13-5,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0011e.html,"JP_CHRIP: It was classified in Category 1 base on a result as ""highly corrosive"" in a rabbit test (IUCLID (2000)) and a result indicating ""corrosion"" in another rabbit test (HSDB (2000)).",,JP_CHRIP,1,Cl[Si](Cl)(Cl)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J54.322E,J-GLOBAL,Cl[Si](Cl)(Cl)c1ccccc1,Train "EU_REACH: 1-chloro-3-(trifluoromethyl)benzene",,98-15-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19799/7/4/2/?documentUUID=da93ee4f-47e1-45f8-8309-595e50d30ad6,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC(=C1)Cl)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/7374,PubChem,FC(F)(F)c1cccc(Cl)c1,Train "AU_HCIS: 1,2-Benzenediol, 4-(1,1-dimethylethyl)- NZ_CCID: 4-t-Butylpyrocatechol","NZ_CCID: 4-tert-butylcatechol",98-29-3,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6586 NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/779E6331-F4AE-4B13-9B1B-352BDCAA6AB2","NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,"AU_HCIS, NZ_CCID",2,CC(C)(C)C1=CC(=C(C=C1)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/7381,PubChem,CC(C)(C)c1ccc(O)c(O)c1,Train "EU_REACH: ethyl 1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate",,98349-25-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10623/7/4/2/?documentUUID=2291aa59-18ef-485e-a4f1-205ef78b096e,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1=CN(C2=CC(=C(C=C2C1=O)F)F)C3CC3,https://pubchem.ncbi.nlm.nih.gov/compound/9817544,PubChem,CCOC(=O)c1cn(C2CC2)c2cc(F)c(F)cc2c1=O,Train "EU_REACH: trans-1,4-bis(isocyanatomethyl)cyclohexane",,98458-83-4,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26702/7/4/2/?documentUUID=fecb723c-8202-4de1-bb82-06bf9427fb51,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC(CCC1CN=C=O)CN=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/61504,PubChem,O=C=NCC1CCC(CN=C=O)CC1,Train "NZ_CCID: 4-Bromobenzenesulphonyl chloride",,98-58-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2893EFAD-9CC9-4251-834A-0027964E8BE9,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1S(=O)(=O)Cl)Br,https://pubchem.ncbi.nlm.nih.gov/compound/7396,PubChem,O=S(=O)(Cl)c1ccc(Br)cc1,Train "NZ_CCID: 4-Toluenesulphonyl chloride","NZ_CCID: 4-Methylbenzenesulfonyl chloride, 4-Toluenesulfonyl chloride, Benzenesulfonyl chloride, 4-methyl-, Tosyl chloride, p-Methylbenzenesulfonyl chloride, p-Toluenesulfochloride, p-Toluenesulfonic acid chloride, p-Toluenesulphonyl chloride, p-Tolylsulfonyl chloride, p-Tosyl chloride, para-Toluenesulfonyl chloride",98-59-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/38C8068C-2B7E-4CA4-AB65-012C913832B8,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC1=CC=C(C=C1)S(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7397,PubChem,Cc1ccc(S(=O)(=O)Cl)cc1,Train "NZ_CCID: 4-Chlorobenzenesulphonyl chloride",,98-60-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4168693B-5296-46E1-89C3-386A788C54E0,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1S(=O)(=O)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7398,PubChem,O=S(=O)(Cl)c1ccc(Cl)cc1,Train "NZ_CCID: 4-Methoxybenzenesulphonyl chloride",,98-68-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B4755BD2-F16B-4465-92A1-033F6D04568A,"NZ_CCID: Skin Irritation R PHRASE: R 34 [CHEMWATCH] Eye Irritation R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,COC1=CC=C(C=C1)S(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7401,PubChem,COc1ccc(S(=O)(=O)Cl)cc1,Train "NZ_CCID: 4-Nitrobenzenesulphonyl chloride",,98-74-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D222C6C1-5B24-4F4F-90EF-213D01E3C7BF,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1[N+](=O)[O-])S(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7404,PubChem,O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1,Train "JP_CHRIP: Cumene","JP_CHRIP: (1-Methylethyl)benzene 1-Methylethylbenzene 2-Phenylpropane isopropylbenzene isopropylbenzene [synonym:cumene]",98-82-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-mhlw-2011.html,"JP_CHRIP: 【分類根拠】 （１）より、区分に該当しない。 【根拠データ】 （１）ウサギ（n= 6）を用いた皮膚刺激性試験（OECD TG404相当、無傷／有傷皮膚、72時間観察）では、24及び72時間後の観察で浮腫はみられなかったが、軽度で回復性のある紅斑が全例にみられた。6例の個体別平均スコア（フルスコア：8）は各々2、1.5、2、2、2及び1.5で無傷皮膚と有傷皮膚には差はなかった（AICIS IMAP (2016)、EU RAR (2001)、ACGIH (7th, 2001)、厚労省 リスク評価書 (2015)、産衛学会 許容濃度暫定値の提案理由書 (2019)、REACH登録情報 (Accessed Dec. 2021)）。 【参考データ等】 （２）本物質は皮膚刺激性物質である（AICIS IMAP (2016)、NTP(2009)）。 （３）厚労省 リスク評価書 (2015)では、皮膚刺激性/腐食性：軽度の刺激性とされた。 （４）ウサギを用いた皮膚刺激性試験（原液0.5 mL、24時間適用）では、皮膚剥離を伴う軽微な脱脂作用がみられ、軽微な皮膚刺激性と判定された（ACGIH (7th, 2001)、厚労省 リスク評価書 (2015)、産衛学会 許容濃度暫定値の提案理由書 (2019)）。",Provided,JP_CHRIP,1,CC(C)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.581E,J-GLOBAL,CC(C)c1ccccc1,Train "AU_HCIS: benzoyl chloride JP_CHRIP: Benzoyl chloride KR_NCIS: Benzoyl chloride NZ_CCID: Benzoyl chloride US_HSDB: Benzoyl chloride","JP_CHRIP: alpha-Chlorinated toluenes (benzal chloride, benzotrichloride, benzyl chloride) and benzoyl chloride (combined exposures) alpha-Chlorobenzaldehyde Benzenecarbonyl chloride Benzoic acid chloride KR_NCIS: Benzenecarbonyl chloride; Benzoic acid chloride NZ_CCID: Benzenecarbonyl chloride, Benzoic acid, chloride",98-88-4,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=457 JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-mhlw-2015e.html KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances"" NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BDEC200B-FA30-411E-A0FD-F2252AD43C67 US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/383","JP_CHRIP: [Rationale for the Classification] Based on (1)-(3), it was judged that this substance is corrosive to the skin, and it was classified in Category 1. [Evidence Data] (1) It is described that this substance is corrosive to humans in multiple articles in literature (NICNAS IMAP (Accessed Aug. 2018), Vincoli (1996), Bruze et al. (2000)). (2) In a skin irritation test (n=6) with rabbits, after a 4-hour application followed by 72-hour observation, an irritation score of 3.8 is reported (REACH registration dossier (Accessed Aug. 2018)). (3) There is also a report that this substance is very strongly irritating to rabbit skins (Risk Assessment Report (Ministry of Health, Labour and Welfare, 2008), ACGIH (7th, 2001)). [Reference Data, etc.] (4) This substance was classified as ""Skin Corr. 1B"" in the EU CLP. NZ_CCID: Skin Irritation R-PHRASE: R 34 UN CLASS: 8 PG II [ICSC 2000] Eye Irritation EU Classification Symbol: C R: 34 S: (1/2-)26-45 EFFECTS OF SHORT-TERM EXPOSURE: Tear drawing. The substance is corrosive to the eyes, the skin and the respiratory tract. Corrosive on ingestion. Inhalation of the vapour or aerosol may cause lung oedema (see Notes). [ICSC 2000]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,ClC(=O)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.987J,J-GLOBAL,O=C(Cl)c1ccccc1,Train "JP_CHRIP: N,N-Dimethylcyclohexylamine NZ_CCID: Cyclohexyldimethylamine","JP_CHRIP: N,N-Dimethyl-cyclohexylamine Cyclohexanamine, N,N-dimethyl- Cyclohexylamine, N,N-dimethyl- Cyclohexyldimethylamine N,N-Dimethylaminocyclohexane N-Cyclohexyldimethylamine NZ_CCID: (Dimethylamino)Cyclohexane, N, N-Dimethylcyclohexanamine, N,N-Dimethylcyclohexylamine",98-94-2,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2015e.html NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D1F03E47-69FF-4B3D-BF20-ABA7BDE1E357","JP_CHRIP: Based on a report that it was corrosive in a skin irritation test with rabbits, and a description that the 5 g/L aqueous solution of this substance was pH 12 (GESTIS (Access on May 2017)), and that the corrosive properties were attributable to the alkaline properties of the aqueous solution of this substance (SIAP (2012)), it was classified in Category 1. NZ_CCID: Skin Irritation N,N-Dimethyl-cyclohexylamine has a specific UN number 2264 Class 8 Sub risk 3 packing group II, with risk phrases R10,R20/21/22,R34. Class 8 packing group II is equivalent to an HSNO 8.2B classification. Eye Irritation N,N-Dimethyl-cyclohexylamine has a specific UN number 2264 Class 8 Sub risk 3 packing group II, with risk phrases R10,R20/21/22,R34.",,"JP_CHRIP, NZ_CCID",2,CN(C)C1CCCCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.960C,J-GLOBAL,CN(C)C1CCCCC1,Train "EU_REACH: (2R)-6-fluoro-2-[(2R)-oxiran-2-yl]-3,4-dihydro-2H-1-benzopyran; (2R)-6-fluoro-2-[(2S)-oxiran-2-yl]-3,4-dihydro-2H-1-benzopyran; (2S)-6-fluoro-2-[(2R)-oxiran-2-yl]-3,4-dihydro-2H-1-benzopyran; (2S)-6-fluoro-2-[(2S)-oxiran-2-yl]-3,4-dihydro-2H-1-benzopyran",,99199-90-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7989/7/4/2/?documentUUID=c0d62c61-66f0-4edb-9563-92c0f06152b6,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC2=C(C=CC(=C2)F)OC1C3CO3,https://pubchem.ncbi.nlm.nih.gov/compound/11658439,PubChem,Fc1ccc2c(c1)CCC(C1CO1)O2,Train "EU_REACH: trehalose",,99-20-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26864/7/4/2/?documentUUID=77f7f2d0-73f4-429d-b101-7c237782ac02,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)O)O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/7427,PubChem,OC[C@H]1O[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O,Train "EU_REACH: 4,4'-Methylenebis(N-butoxycarbonylcyclohexanamine)",,99305-42-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20249/7/4/2/?documentUUID=e113222c-646e-45bf-b87e-8df97c8f14f8,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOC(=O)NC1CCC(CC1)CC2CCC(CC2)NC(=O)OCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/11742316,PubChem,CCCCOC(=O)NC1CCC(CC2CCC(NC(=O)OCCCC)CC2)CC1,Train "EU_REACH: trimethylsilane",,993-07-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19701/7/4/2/?documentUUID=b97fb748-c412-4f1e-8725-5e76728b4248,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[SiH](C)C,https://pubchem.ncbi.nlm.nih.gov/compound/70435,PubChem,C[SiH](C)C,Train "NZ_CCID: 3,5-Dinitrobenzoyl chloride",,99-33-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/42A7A118-D942-47EB-9B2E-063759012F7E,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=C(C=C(C=C1[N+](=O)[O-])[N+](=O)[O-])C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7432,PubChem,O=C(Cl)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1,Train "JP_CHRIP: tert-Amyl methyl ether [TAME or 2-methoxy-2-methylbentane]","JP_CHRIP: 1,1-Dimethyl propylmethyl ether 2-Methyl-2-methoxybutane Butane, 2-methoxy-2-methyl- Methyl-tert-pentyl ether TAME tert-Pentyl methyl ether",994-05-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0020e.html,"JP_CHRIP: In a skin irritation test using rabbits (OECD TG 404, GLP compliance), 4-hour application with 500 micro L this substance (98.4%) resulted in the irritation score of 0, and it was judged to be not irritating (EU-RAR (2006)). From the above result, it was judged to be ""Not classified.""",Provided,JP_CHRIP,1,CCC(C)(C)OC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J125.007H,J-GLOBAL,CCC(C)(C)OC,Train "EU_REACH: chlorotriethylsilane NZ_CCID: Chlorotriethylsilane",,994-30-9,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19870/7/4/2/?documentUUID=0376eda7-1481-43e3-a105-965f183d3948 NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/12EB044C-011B-450A-B037-2351BF6AA3D1","EU_REACH: Experimental study (OECD TG 404, GLP) NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",Provided,"EU_REACH, NZ_CCID",2,CC[Si](CC)(CC)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/13819,PubChem,CC[Si](Cl)(CC)CC,Train "JP_CHRIP: 1,2-Dichloro-4-nitrobenzene","JP_CHRIP: 1,2-Dichloro-4-nitrobenzene 3,4-Dichloronitrobenzene Benzene, 1,2-dichloro-4-nitro- DCNB",99-54-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-meti-0017e.html,"JP_CHRIP: Since the 24 hour skin irritation/corrosion test with rabbits (OECD TG 404, GLP) did not identify skin irritation (average scored values for erythema/crust and edema:0.2, 0.0) (SIDS (2003)), it was classified into ""Not classified"".",Provided,JP_CHRIP,1,[O-][N+](=O)c1ccc(Cl)c(Cl)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.584J,J-GLOBAL,O=[N+]([O-])c1ccc(Cl)c(Cl)c1,Train "EU_REACH: 1,5,2,4-dioxadithiane 2,2,4,4-tetraoxide",,99591-74-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7762/7/4/2/?documentUUID=e8145276-df84-424d-8ad0-bc3ae18b5e65,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1OS(=O)(=O)CS(=O)(=O)O1,https://pubchem.ncbi.nlm.nih.gov/compound/11600810,PubChem,O=S1(=O)CS(=O)(=O)OCO1,Train "EU_REACH: 3,4,5-trifluorophenol",,99627-05-1,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/4466/7/4/2/?documentUUID=738c89d3-4675-48a2-aa3a-8b1832b39883,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(C=C(C(=C1F)F)F)O,https://pubchem.ncbi.nlm.nih.gov/compound/2777943,PubChem,Oc1cc(F)c(F)c(F)c1,Train "EU_REACH: dimethyl(propan-2-yl)amine",,996-35-0,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13880/7/4/2/?documentUUID=7425a16d-9690-43c5-990d-bb20be72b921,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/70452,PubChem,CC(C)N(C)C,Train "JP_CHRIP: m-Dinitrobenzene","JP_CHRIP: 1,3-Dinitrobenzene 1,3-Dinitrobenzol 1,3-DNB Benzene, 1,3-dinitro- dinitrobenzene m-Dinitrobenzene",99-65-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2049e.html,"JP_CHRIP: [Rationale for the Classification] Based on (1) and (2), it was classified as ""Not classified."" [Evidence Data] (1) In a skin irritation test with rabbits according to OECD TG 404, it revealed no irritation (GESTIS (Access on July 2019)). (2) Although details were unknown, there is a report that no irritation was observed in a skin irritation test with rabbits (ATSDR (1995)). [Reference Data, etc.] (3) In a skin irritation test with guinea pigs applied with a formulation containing 0.5% of this substance, no irritation was observed (ATSDR (1995)).",Provided,JP_CHRIP,1,[O-][N+](=O)c1cccc(c1)[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.177K,J-GLOBAL,O=[N+]([O-])c1cccc([N+](=O)[O-])c1,Train "NZ_CCID: Diethylaminotrimethylsilane","NZ_CCID: N,N-diethyltrimethylsilylamine",996-50-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FF37B5D2-C349-4EE7-B15B-2363FF81881A,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCN(CC)[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/70454,PubChem,CCN(CC)[Si](C)(C)C,Train "EU_REACH: 1,2,3-trichloro-12,24-dihydro-5H-naphtho[2,3-h]naphtho[2'',3'':6',7']indolo[2',3':6,7]anthra[2,1,9-mna]acridine-5,10,13,18,25-pentone",,99688-45-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24668/7/4/2/?documentUUID=e9988da8-b9fa-423f-a563-dcb52766b31c,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)C(=O)C3=C(C2=O)C4=C(C=C3)C5=CC6=C(C=C5N4)C(=O)C7=C8C6=C(C(=C9C8=C(C=C7)C1=C(N9Cl)C2=C(C=C1)C(=O)C1=CC=CC=C1C2=O)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/44147486,PubChem,O=C1c2ccccc2C(=O)c2c1ccc1c2[nH]c2cc3c(=O)c4ccc5c6ccc7c(c6n(Cl)c6c(Cl)c(Cl)c(c3cc21)c4c56)C(=O)c1ccccc1C7=O,Train "JP_CHRIP: p-sec-Butylphenol","JP_CHRIP: 4-(1-methylpropyl)phenol p-sec-butylphenol",99-71-8,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0072e.html,"JP_CHRIP: In a test by a 4-hour semi-occlusive application of 0.5 mL of the undiluted solution of this substance liquefied by heating to the rabbit skin (GLP-compliant), all six animals showed necrosis, PII (primary irritation index) was 7.25, and it was concluded to be corrosive (HPVIS (2009)). Therefore, it was classified in Category 1.",,JP_CHRIP,1,CCC(C)c1ccc(O)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J362J,J-GLOBAL,CCC(C)c1ccc(O)cc1,Train "NZ_CCID: 2,4'-Dibromoacetophenone",,99-73-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EF35CDD3-C8B4-41E2-9F8F-F6B499D9D2D1,"NZ_CCID: Skin Irritation R PHRASE: R 34 [Company Data] Eye Irritation R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1C(=O)CBr)Br,https://pubchem.ncbi.nlm.nih.gov/compound/7454,PubChem,O=C(CBr)c1ccc(Br)cc1,Train "JP_CHRIP: 4-Isopropylaniline","JP_CHRIP: 4-isopropylaniline",99-88-7,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0013e.html,"JP_CHRIP: On the basis of a result as ""corrosive"" in a test using rabbits (OECD TG 404: GLP) (IUCLID (2000), it was classified in Category 1.",Provided,JP_CHRIP,1,CC(C)c1ccc(N)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J11.624F,J-GLOBAL,CC(C)c1ccc(N)cc1,Train "JP_CHRIP: 2-Hydroxypropyl acrylate US_HSDB: 2-Hydroxypropyl acrylate","JP_CHRIP: 2-Propenoic acid, 2-hydroxypropyl ester Acrylic acid, 2-hydroxypropyl ester beta-Hydroxypropyl acrylate Propylene glycol monoacrylate",999-61-1,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0067e.html US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/7913","JP_CHRIP: It is reported that in a skin irritation test using rabbits, moderate edema and moderate to severe necrosis were observed after this substance (170 to 250 mg/kg) was locally applied, and moderate chemical burns were found after application of a 10% aqueous solution (ACGIH (7th, 2001)). Moreover, it is reported that moderate irritation was found after open application of an isomer mixture containing 75% this substance (25% 1-hydroxy-2-propyl acrylate) to rabbit skin (DFGOT vol. 16 (2001)). Furthermore, it is reported that severe deep-seated necrosis was observed after 15-minute or 4-hour occlusive application of an isomer mixture containing 66% this substance (33% 1-hydroxy-2-propyl acrylate, 1% free acrylic acid or 1-hydroxy-3-propyl acrylate) (animal species: unknown) (DFGOT vol. 16 (2001)). From the above reports, the substance was classified in Category 1. Besides, it is classified in ""Skin. Corr. 1B H314"" in EU CLP classification (ECHA CL Inventory (Access on September 2015)).",,"JP_CHRIP, US_HSDB",2,CC(O)COC(=O)C=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J33.773K,J-GLOBAL,C=CC(=O)OCC(C)O,Train "EU_REACH: 4-hydroxybenzoic acid",,99-96-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15944/7/4/2/?documentUUID=500bdcb0-2581-4d12-8cfb-3faea4b487c7,"EU_REACH: Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1C(=O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/135,PubChem,O=C(O)c1ccc(O)cc1,Train