diff --git "a/data.json" "b/data.json" deleted file mode 100644--- "a/data.json" +++ /dev/null @@ -1 +0,0 @@ -[{"text":""Tapering doses" protocol arm was not effective for treatment retention outcome.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"1 Indication for further investigations (brain ultrasound). 2 Change of study design to\u00ca efficacy study with historical control group.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"1. Very low enrollment rate. \u00ca \u00ca 2. Recent studies question the effect of adding panitumumab in this category of patients. \u00ca \u00ca 3. Too high toxicity rate","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"10\/2005 PI assigned duties as trauma physician in addition other duties","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"12\/15\/2008 Voluntarily placed on inactive status-requested by the PI","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"13 of 15 patients recruited.Study patients responded with no safety signals. Recruitment\u00ca slow,timely end of study necessary to keep development timelines","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"2 complications with midazolam","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"20 subjects completed for a pilot, further funding required to continue study\"","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"2011 Thailand flooding led to loss of GMP pharmacy, project delays, and further regulatory \u00ca challenges.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"36 cases were included and the 4 centers and they are unable to increase their recruitment to obtain the 400 cases necessary to reach statistical significance.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"5 immune related serious adverse events in Phase 1 study","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"50% of eligible patients refused to enter the study","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"6 month vital status report not collected after 28 day follow up analysis indicated no difference between placebo & tezosentan","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"65 patients were included after 2 years instead of 140","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"7% enrollment. Study terminated after a small number of recruited patients","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"A 300 patient safety analysis by the Data Monitoring Committee showed a trend towards higher mortality in the treatment group.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"A business decision was made to not initiate this study.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"A cluster of adverse events in everolimus arm was noted.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"A cluster of deaths in the BCG-arm compared with controls","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"A decision was made to discontinue the study due to a change in the strategic direction of the company.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"A decision was made to not move forward with the study. No participants were enrolled or \u00ca treated.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"A higher rate of late rejection was seen in the low tacrolimus arm.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"A lack of a potential patient.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"A new alternative treatment caused the decrease in the rhythm of recruitment.","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"A new alternative treatment for patients who have progressed after treatment with trastuzumab, has caused the decrease in the rhythm of recruitment.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"A new protocol was developed to replace this protocol in 2008, with removal of ATG and\u00ca extension of MMF duration.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"A new study has began recently","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"A new study is being designed. No patients were enrolled.","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"A paper on the same topic came out just before we wanted to start our study.","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"A pending new protocol will replace this study.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"A planned interim analysis was performed after approx. 240 subjects completed the trial. The study was stopped, as permitted by protocol, after the analysis.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"A preliminary analysis of 11 patients confirmed the safety profile of NCX-1000 but did not demonstrate the efficacy required.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"A re-evaluation of research risks to participants were greater than originally anticipated","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"A significant reduction in head injuries coupled with more frequent use of crainectomy reduced \u00ca the number of potential subjects.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"A sister study using Frova at a 10 mg dose had adverse effects.","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"AG-1749 superior to Gefarnate in ulcer prevention","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true},{"text":"AMAG not continuing with Combidex, the study drug\"","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"AML assessment of response in the Part B patients (9) find treatment failure in all instances.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"AOI Pharma is reassessing the development strategy for perifosine.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"AOI Pharmaceuticals, Inc. decided to terminate the license agreement. No further clinical development by AOI Pharmaceuticals, Inc. will be pursued.\"","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"APPRISE closure prompted by SWOG S0205 not meeting primary endpoint-improving OS. APPRISE enrollment closure due to similar design;no unexpected safety data","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"AVE5530 in hypercholesterolemia was stopped due to insufficient efficacy","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"AZ decision to discontinue fostamatinib development in RA; rights to fostamatinib returned to \u00ca Rigel Pharmaceuticals.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"AZD1704 has essentially similar PK profile in Japanese subjects as in Caucasians. One of the main purposes of the study has thereby been achieved.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Abandoned due to lack of recruitment Oct 2006","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Abnormality prevalence revealed to be much lower than expected.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Absence of patients for recruitment","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"According to the study design, in the first step the number of responses was lower than the number required (< 7).\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Accrual Goal Met","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Accrual and treatment with CG1940\/CG8711 stopped due to IDMC recommendation.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Accrual factor","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Accrual goal for interventional part not achievable","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Accrual has been very slow. We are currently determining whether or not to keep the trial going as is or to close the trial and write a new protocol.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Accrual is suspended due to COVID-19.","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Accrual is very poor","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Accrual problems","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Accrual rate was too 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optimized","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Accrual was suboptimal and increasing the number of patients was not feasible.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Accrural was completed","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Achieving site readiness and enrolling the trial within a reasonable time","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Acrrual target was not being met","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Active Duty principle investigator currently deployed","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"Additional equipment is needed.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Additional 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complete.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true},{"text":"Adult patient population barriers.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Adverse Events","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Adverse findings from nonclinical carcinogenicity studies.","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"After 1 year only 2 subjects enrolled and treated thus no meaningful efficacy analyses could be performed.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"After 190 weeks [7 patients left] it was terminated for administrative reasons","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"After IELSG25A study amendment, patients subject of the present study were eligible for inclusion in the IELSG25A study\"","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"After Preliminary results indicate need to make numerous changes to protocol, and therfore will end, rewrite, and then begin again.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"After a discussion, we decided to withdraw the study.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"After an extensive review,the ASPIRE in CKD study was terminated because it was not possible to complete the study in an appropriate time frame.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"After an extensive review,the ASPIRE in CKD study was terminated because it was not possible\u00ca to complete the study in an appropriate time frame.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"After initiation of study many studies reported an equivalence of SNB and ALND which led to \u00ca widespread adoption of the former as standard procedure.","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"After interim analysis it was determined that the risks were too great in comparision to the\u00ca results","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"After interims analysis standard errors for inflammatory and nutritional markers varied \u00ca widely, that the power calculation required unattainable goals","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"After pilot study no difference in the primary end point was found between the two primary.\u00ca Non-inferiority trial not deemed feasible.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"After primary completition date, experimental drug was no longer available","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"After reports of turbidity in urine in 4 of 8 volunteers in the 4th cohort, the study was halted temporarily.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"After review of safety events and have decided that further dose escalation of MEDI-507 as a single agent is not feasible.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"After treatment of 7 patients, it was decided that the handling characteristics of the test device should be upgraded before continuing the trial as planned.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"After utilizing all available recruitment resources, it was determined that the recruitment goal for the study could not be achieved\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"After year 1, there was insufficient statistical power to detect a difference in the primary outcome measure during planned study period.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Aims of the study re-evaluated, did not justify allocation of resources.\"","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"All AstraZeneca sponsored clinical trials of AZD8931 have been halted","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"All enrollment, treatment, follow-up & data analysis completed\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"All of the mentioned aim and objectives were achieved before the February 2007","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"All patients during the study period were subjected to peripheral blocks or were excluded from\u00ca the study due to exclusion criteria","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"All patients recruited","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"All sites have been put on hold due to the ongoing COVID-19 pandemic","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"All subject enrollment\/follow up is on hold due to COVID-19 pandemic","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"All the patients were included","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Alternate study projected to assess imaging endpoints versus clinical endpoints.","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Alternative trial planned","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Amendment requested for this study - waiting for Regulatory Approval of the Amendment","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Amgen decision following interim review of efficacy and safety data from the AMG 337 program.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Amgen determined no further need for this study.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"An alternative joint industry effort will provide information on combination versus single\u00ca agent therapy for treatment of aspergillosis","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"An endpoint difference between 3 energies was not observed. Correlations between recovery and ATP were established, and will be used for a Whole Blood system.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"An independent DMC determined continuation was unlikely to demonstrate a statistically significant advantage of ASP8825 over placebo on the primary endpoint","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"An interim analysis revealed a significantly higher persistence\/recurrence of complications of portal hypertension in the 8 mm-stent group.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"An interim analysis showed that nitric oxide patches are not enough effective","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"An interim data analysis found no significant difference between testing groups.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Analysis of data from 104RA202 failed to meet primary endpoint","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Analysis of data from 104RA203 failed to meet primary endpoint.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Ancillary data being reviewed to determine if this study will continue.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Angioscanners in excess of the SNA group because of use of thiopental","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Animal Safety Data","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Animal Toxicity Findings","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Another study enrolling the similar group of patient are ongoing","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Another study has been planned, so we did not initiate this one.","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Another study was opened.","Another_Study":true,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Another treatment found efficacious","Another_Study":true,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Another trial in the department directly competes for the the same patient population","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Anticipated number of patients not achieved. All Patients recruited in the study completed all study visits.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Anticipation of inadequate recruitment according to current format.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Approval lapse","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Arm A - reached goal; Arm B - poor accrual","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"As Continuing Review application to IRB was not submitted on time","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"As another Mps1 inhibitor was being developed in parallel, the strategic decision was to move\u00ca forward with the development of the follow up compound only.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"As no safety warnings were detected,Interim analysis from the first 40 patients reccomends to stop the trial for futility\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"As recommended by the DSMB.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"As the recruitment rate was very low, a futility study was conducted and it was decided to\u00ca discontinue inclusions","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Assessing resources needed to extend study.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"AstraZeneca has discontinued the development of AZD0530. No new AstraZeneca-sponsored clinical studies will be initiated..","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"AstraZeneca withdrew support for the study.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"At half the sample size, the results were negative with no benefit demonstrated with \u00ca adenosine.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"At interim analysis the study did not meet the response criteria to continue","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"At sponsor's discretion","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"At the end of the year 2002, Cameroon switched from chloroquine to amodiaquine as first-line therapy for of uncomplicated malaria.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"At the first prespecified interim analysis","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Attendance at study sites carries risk of COVID-19 infection. Non-attendance at planned study","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Authorization denied","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Autorities vorbidden this dispositif in other trial","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":true,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Availability of Investigational agent","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Avastin approved for first-in-line treatment.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Awaiting IMP license for new GMP suite.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Azidus, the CRO hired for this study by Prevent Senior has lost the interest to conduct this\u00ca study.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"B2151007 was prematurely discontinued due to Pfizer's change in prioritization for the\u00ca portfolio and is not due to any safety concerns or regulatory interaction","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"BMS withdrew support and required this trial to stop enrolling; Phase II portion never began,\u00ca only a Phase I trial.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Based on Independent Data Monitoring Committee (IDMC) recommendation.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Based on a business decision unrelated to any safety concerns.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Based on a consistently low enrolment rate and procedural challenges that were unknown at study start. It was not based on safety or efficacy concerns.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Based on an interim data review, the DSMB concluded that the vaccine cannot be shown in this trial to prevent HIV infection or affect the course of the disease.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Based on analyses in Phase I, the study did not advance to Phase II.","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Based on analysis of results and consideration of available treatments, the overall benefit to\u00ca risk profile of ocrelizumab was not favorable in RA.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Based on data collected, the combination appeared to be poorly tolearated.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Based on futility analysis showing <30% chance of meeting primary endpoint.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Based on input from regulatory agencies, it is not necessary to conduct this study. An ongoing study was sufficient for regulatory purposes.\"","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Based on interim analysis at the end of Stage 1, and predefined stopping rules for futility, further enrollment was stopped due to lack of efficacy\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Based on interim analysis at the end of Stage 1, and predefined stopping rules for futility,\u00ca further enrollment was stopped due to lack of efficacy","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Based on overall benefit-risk assessment.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Based on preliminary parent study results","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Based on the data and observed benefit-risk profile, the trial's independent oversight committee recommended that enrollment not resume.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Based on the data collected, the combination of bevacizumab and sunitinib appeared to be poorly tolerated.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Based on the outcome of the planned first interim analysis, it was decided not to continue the trial. No safety concerns were identified.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Based on the results of the Phase 1 data, the company decided not to pursue the development of\u00ca this drug at this time.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Based upon preliminary safety and efficacy results from a similar study.","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Bayer Healthcare is no supplying the study drug","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Bayer terminated the program and sold the IP to Medronic","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Beacuse of unexpected administrative barriers, only 5 cases were enrolled in a year.\"","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Because of a strategic decision by Novartis","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Because of approval of Bevacizumab, it was difficult to perform clinical study in 1st line setting.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Because of lack of funding and recruitment problems the study has been 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advancement.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Could not recruit","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Could not recruit any more people.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Covid 19 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pandemic","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Covid-19 pand\u00cc\u00a9mie","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Covid-19 resolution.","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Created Extension study","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Created Extension study - This study was no longer 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policies.","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Currently suspended due to covid-19 policies.","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Curretly suspended due to Covid-19 policies.","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"DSMB","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"DSMB felt continuing study will not yield any statistical significance.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"DSMB recommendation for slow enrollment","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"DSMB recommended termination due to lower survival to discharge in primary population and worse discharge CPC scores in the treatment arm than control arm.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"DSMB recommended termination due to lower survival to discharge in primary population and \u00ca worse discharge CPC scores in the treatment arm than control arm.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"DSMB review at 50% recruitment, further recruitment unlikely to change result\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"DSMB reviewed data of 1st 10 subjects; determined no safety concerns. Efficacy as a single agent in this patient population was unlikely. Voluntary Termination","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"DSMB stopped the study based on conclusion of likely futility of treatment on the primary outcome.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"DSMB stopped trial for 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recommending that the trial be terminated\u00ca due to slow enrollment","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"DSMC recommendation based on safety data","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"DSPD focussing on Study 301 to confirm clinical profile before proceeding.","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Data Monitoring Committee cited poor accrual.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Data Monitoring Committee decision on 22nd August 2011 for safety issues","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Data Safety Monitoring Committee decision","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Data inconclusive.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Data presented at SABCS 2010 showing that dual blockade is superior to monotherapy","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Date of termination was Feb. 7, 2008. Reasons of termination were due to elevation of liver function tests and long elimination half-life of the compound.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Decided to conduct study in adults first","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Decision made by B&L to cancel the study, no subjects enrolled.\"","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Decision of the Sponsor, as the funding of the study was no longer guaranteed.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Decision of the Steering Committee. Recruitment more difficult and slower than expected.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Decision of the investigator","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Decision to change trial design.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Decision to discontinue due to challenges of trial design and constraints on enrolling eligible\u00ca and consenting patients.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Decision to modify the product under study as a result of feedback regarding subjective feeling during installation procedure. For more info, see brief summary.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Decision to obtain PK data at a later date","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Decision to stop study due to low recruitment.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Decision to terminate recruitment on this study was based on lack of efficacy observed to date","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Decision was taken by Wyeth Sr. Management to early terminate the 3100N7-210 study (terminate enrollment but complete follow-up).","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Definitive discontinuation according to safety monitoring of death from the 46th patient\u00ca onwards.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Delay in the R&D stage","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Delayed recruitment","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Delayed recruitment as compared to that expected","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Delayed start of the trial, both treatment options already have market authorizations, study \u00ca medication expired","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Delayed to review safety 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enrolled.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Development of Current Formulation has Ceased","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Development of JNJ-64041757 in combination with nivolumab discontinued due to lack of clinical\u00ca benefit observed in the Phase 1b 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discontinued","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Development of this compound was discontinued.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Development program ended due to inability to pair with other cytidine analogs and higher risk\u00ca of hyperlipasemia when not used with 3TC\/FTC.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Development program terminated.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Development project 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PI withdrew rather than reapply to FDA. 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contracts for integrated care programs","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Difficulty finding eligible sites\/patients; current situation in health policy cause negative effect on existing\/planned contracts for integrated care program","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Difficulty finding the required patient population","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Difficulty finding the required subject 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trial","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Difficulty in recruiting patients for the study","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Difficulty in recruiting 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patients","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Difficulty meeting patient accrual goals","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Difficulty obtaining 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Study put on full clinical hold.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Dose limiting toxicities on lowest dose level","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Dosing stopped","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Dr. Grose has left this practice, this study is terminated\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"Dr. Holguin is relocating.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"Dr. Jorizzo has decided to withdraw from this study due to the time it is taking to get the study started.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Dr. Milla has left University of Minnesota. 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Study should reopen in February, 2008\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Drug supply unavailable.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Drug 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market.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Drug withdrawal","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Drug withdrawn from market","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Drugs unavailable- study terminated 1\/2\/18","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Drugs unavailable:unable to make radioactive 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time","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Due to COVID-19 outbreak, study is temporarily suspended.","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Due to COVID-19 policies.","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Due to COVID-19, effective 3\/19\/2020 recruitment is halted until further notice","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Due to COVID-19.","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Due to FDA comments, indications for use were chnaged and a different population will be proposed shortly\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Due to Health Canada losartan recall, a new formulation being added to the 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The study is not being terminated for safety reasons.\"","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Due to portfolio\/business decisions by the sponsor","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Due to potential concerns about liver safety (See Detailed 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of\u00ca alternative rabies vaccines), Rabipur will no longer be supplied to China.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Due to technical issues relating to the Electronic diary data.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Due to termination of study D3801C00001, due to 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Ongoing, randomised patients are managed per Trial Protocol.","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Due to the high rate of morbidity and mortality","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Due to the impact of COVID-19","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Due to the lack of enrolment and complexity of design, the QAX576A2103 study in asthma was terminated. 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met","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Enrollment goals unable to be reached.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Enrollment has been terminated due to a slow rate of 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patients.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"FDA concerns regarding Avandamet","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"FDA drug recall on July 30, 2010","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"FDA has placed all trials involving Pacritinib on Full Clinical Hold","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Facet no longer has ownership of 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No adverse outcome has occurred in a study patient.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Failure rate was 100% in one arm of the study (the intervention)","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Failure to Recruit in a Timely 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.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Failure to recruit sufficient participants","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Failure to recruit sufficient 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support.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Field Safety Notice related to potential ventricular oversensing associated to the PhD feature\u00ca on Paradym ICDs","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Final study report has been completed and submitted","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Financial Constraints","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Financial and administrative matters did not allow collaboration among 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The second subject is not in compliance \u00ca with follow ups. 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After performing preclinical follow-up studies, volunteers were no longer available for continuation.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Following recommendation by SOLAR Study IDMC, Astellas closed enrollment in ASP8273 studies.","Another_Study":true,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Following the recall of Ionsys, the study has been stopped. 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Patients on the trial continute to \u00ca receive treatment and are being followed up as part the protocol.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Formulation issues.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"From Sept.\/08 to April\/09 only 30 subjects were recruited. 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1","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"In 2013 the FDA put a temporary hold on the trial and the Phase II portion of this study was\u00ca cancelled.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"In a Phase II study in HIV-infected patients there were a number of seizures, although exact\u00ca causality could not be assessed phase 1 activity was terminated.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"In accordance with protocol's predefined criteria and Data Monitoring Committee recommendation due to insufficient level of efficacy","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"In light of the cessation of non-essential clinical activities at CPU due to the COVID-19","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"In light of the company's current financial position we have indefinately suspended the Rheo-AMD trial.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"In most sites had difficult to recruitting subjects.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"In order to join forces with another study already running which aims to answer the same 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COVID-19.","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"In the Netherlands we wanted to add pilimumab to nivolumab. 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transferring IRB to PI's current institution.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"Inability meet enrollment in study population.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Inability to accrue additional sites and enroll an adequate number of 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A comparison between GHD adults and controls was completed.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Inadequate toxicity","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Incidence of GI Perforation","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Incidence of abnormalities of liver function tests is higher than expected in this population.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Inclusion rate too low due to a lack of eligible patients and difficulties obtaining informed consent.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Inclusion, treatments and follow-up are finished\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Inclusion-rate does not seem feasible anymore to obtain te required number of patients before the end of the trial.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Inclusion\/Exclusion criteria was too stringent to enroll patients at this site.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Incomplete data","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Incorporating the recommendations of the NIH-formed DSMB in the study procedures would make the project budget over the limit for this funding mechanism.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Increased use of commercial product; less eligible patients & poor enrollment.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Incyte has suspended development of the compound.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Independent steering committee has stopped the trial based on results of a prespecified, blinded interim analysis. It was not stopped due to safety concerns.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Industry Funding Withdrawn","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Industry support and funding not forthcoming","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Infectious Disease Outbreak: COVID-19","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Initial PI Dr. Marentis left the University of Michigan hospital","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"Initial PI left, study not continued","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"Institution decided on starting a new protocol of sedation, with another methods and that\u00e5\u00c0s \u00ca why this study has not 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arms","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Interim analysis showed no difference in outcome between treatment groups.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Interim analysis showed no drug 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higher than described in medical literature.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true},{"text":"Interim analysis, infliximab did not reduce number of first relapses in GCA or cumulative glucocorticosteroid dosage\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Interim analysis-DSMB stated good safety profile but lack of efficacy","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Interim data analysis showed no effect between treatment groups","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Interim data indicated that subjects exhibited no meaningful allergic disease during the first ragweed season, making it impossible to measure treatment effect.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Interim efficacy analysis indicated it would be futile to continue study.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Interim results of another trial showed inferior activity of treatment","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Interim review indicated that the dose selected was too high for diabetics","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Interim safety 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proceed.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Internal business decision","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Internal 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patients.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Intervention\/interactions are temporarily paused due to COVID-19 and are expected to resume.","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Investigation of adverse events for a study in Germany using erythropoetin","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Investigational product unavailable due to manufacturing issues","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Investigations on a Suspected Unexpected Serious Adverse Reaction (SUSAR)","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Investigations on a Suspected Unexpected Serious Adverse Reaction (SUSAR) in another trial (Phase II Multiple Myeloma trial EMR63325-008)","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Investigator Resigned","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"Investigator Retired.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"Investigator closed study and left 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Site closed.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"Investigator letter from drug manufacturer stating animal studies showed increased risk of \u00ca cancer which was an unknown adverse event","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Investigator moved to another 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patients.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"It was decided on 9\/21\/2016 to terminate this study early because LogPad devices the patients\u00ca used to record their injection data was flawed","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"It was decided that data from this study are no longer required and therefore it is not\u00ca necessary to expose patients to the study medication","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"It was decided to close the study to further enrollment based on data from a similar study using ABT-751 and Pemetrexed that did not show 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application.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"It was not possible to perform 2 MRI studies in each patient due to practical problems. 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started","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Manufacturer stopped drug development","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Manufacturing change in one of the two lipid emulsion products being 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program.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Not reached the statistical hypothesis at the interim analysis","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Not reaching recruitment and endpoint goals","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Not to expose the patients to subtherapeutic dose","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Notification from 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stop the marketing of BEZ235","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Novartis decided to terminate based on strategic and administrative reasons.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Novartis ended all studies regarding 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sufficient.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Pause for COVID 19 Response","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Pause for COVID 19 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renewal","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Pending Modification","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Pending approval of the Ethics Committee","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Pending further evaluation","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Pending modifications","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Pending production of human use 18F-FMAU","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Per Data Monitoring Committee recommendation","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Per Group Chair: This study will not move forward.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Per IRB COVID\u0089\u00db\u00f019 guidance on conducting human subjects 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Negative \u00ca study results were published therefore analysis was not completed","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Per protocol intermediate analyses of 76 patients and enrollment difficulties.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Per recommendation from DRT","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Per recommendation of the PI; slow accrual","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Per sponsor decision","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Personelle changes mandated suspension.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Pfizer has terminated the execution of this protocol","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Pfizer made a business-related decision on 04May2017 to terminate study based on change in\u00ca portfolio prioritization, and is not due to safety or efficacy.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Pharmaceutical co- re aligned their specialties- no longer will fund H&N ca","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Pharmaceutical company has terminated orteronel (TAK-700) development for Prostate Cancer","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Pharmaceutical company no longer manufactures drug","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Pharmaceutical company supplying the drug withdraw financial support. PI has decided to close\u00ca study prior to enrollment of any patients.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Pharmaceutical sponsor withdrew financial support.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Phase 3 clinical trial of somavaratan in PGHD did not meet its primary 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feasible.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Pilot study showed recruitment rates were lower than expected,and number of losses to \u00ca follow-up, much higher.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Pilot study superseded by a larger NHMRC funded trial","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Pilot study with sumatriptan found no significant changes in the primary outcome parameter\u00ca (change in CBF)","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Plan to change the trial 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reason.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Please see Brief Summary for Termination Reason.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Please see Detailed Description below for termination 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study design not appropriate any longer.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Poor tolerability of drug and side effects","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Poor trial recruitment","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Portfolio consolidation.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Portfolio proritisation","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Portfolio re-prioritization","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Positive FAIR-HF study data are available, this study is identical as EFFICACY-HF. Due to low recruitment in EFFICACY-HF the decision was made to terminate it.\"","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Post-marketing reports of hepatotoxicity associated with obeticholic acid emerged in June 2017,\u00ca investigators temporarily halted patient recruitment June 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participate.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Pre-Clinical Safety Tox Findings","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Pre-specified futility boundary was reached.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Pre-specified interim analysis of safety and efficacy is pending.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Precautionary delay in response to the COVID-19 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insufficient patient recruitement..","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Prematurely terminated based on interim study analysis","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Prematurely terminated due to financial 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interim.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Protocol approval expired","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Protocol being 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chemo and or\u00ca radiation at even higher doses than what is used in this study.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Recommendation after interim analysis","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recommendation of the Data Safety Monitoring 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New study to open soon.","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Recruiting or enrolling participants has halted and will not resume","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruiting or enrolling participants has halted prematurely and will not 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enrolled\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment goals could not be met.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment halted as research group determined that they had sufficient numbers to determine if the intervention had an effect.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment has been suspended because of a problem with the software used for generating the aftercare summary.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment in study could not be reached after 8 yrs of recruiting","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment is suspended due to COVID-19 outbreak","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment is suspended due to COVID-19. Study visits for currently enrolled subjects are","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment is temporarily suspended due to COVID-19 outbreak","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment is temporarily suspended, related to COVID-19.","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment issues","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment lower than estimated","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment not progressing as planned.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment of patients proved much too difficult based on the chosen criteria.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment on hold until IRB review completed","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment problematic","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment problems","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment problems has forced us to change the design of this study from a clinical trial to a comparative study of 3 different groups of patients.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment problems; insufficient number of new recruits","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment slow","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment stopped according to early stopping rule (by protocol)","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment suspended during PI leave X 12 months","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"Recruitment suspended until DSMB reviews a Serious Adverse Event","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment suspending during the COVID-19 pandemic.","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment targets were unachievable in the currently available population.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment temporarily on hold due to COVID-19 situation.","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment temporarily paused due to COVID-19","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment temporarily paused due to COVID-19 and expected to resume.","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment temporarily suspended due to COVID-19 pandemic","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment temporarily suspended due to COVID19 restrictions.","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment temporarily suspended.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment to slow, most patients to well for treatment\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment too slow. Number of eligible patients probably to low. Patients enrolled and\/or in follow-up will be followed up in the Valeo study.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment very difficult. Study drug expired so we have stopped the study.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment was early terminated due to slow recruitment. Not linked to any safety concern.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment was slower than anticipated. Insufficient funding to expand to multi-centered trial.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment was suboptimal","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment was taking longer than originally anticipated.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment was too difficult","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment was too slow and we cannot anticipate to recruit the target sample size","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment was very slow.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment\/study discontinued after withdrawal of marketing authorisation. No data entered.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Recruitment: Insufficient number of patients eligible for enrollment","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Redirect focus of the indication","Another_Study":true,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Reduced access to AchEI medication-naive mild AD patients.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Redundant in-clinic visits increased the workload in virtual follow-up group. An interim \u00ca analysis showed that the study would not support the primary hypothesis","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Refer to Detailed Description.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Registration is less","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Regulatory approval was not obtained for drisapersen, hence BioMarin is stopping the\u00ca development of all exon skipping oligonucleotides in DMD.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Regulatory decision not to proceed","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Regulatory issues(trial temporarily suspended December 28, 2005. Permanently suspended January 19, 2007. Institutional Reveiw Board informed April 18, 2007\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Regulatory reasons","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Rejected ethics approval in UK and Holland","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":true,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Reorganization of personnel forced termination.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"Replaced by a new study","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Replaced by another protocol","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Replaced with an alternate study","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Replaced with another study","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Replaced with ongoing 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participants.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Reprioritization of study programs","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Repros decided to stop study because of safety and FDA decided to put study on 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PI left the institution.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"Study completed","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study completed.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study concept was terminated.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Study could not be re-supplied with study medication in a timely manner.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study currently suspended due to a lack of available funding.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study deemed non-essential under COVID pandemic","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study delayed for over a year by research shutdown at Seattle VA and other issues. 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We did not and will not begin this clinical trial.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Study design was changed and is now listed as InSite for Urinary Urge Incontinence and InSite for Urgency-Frequency","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Study did not get started.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study did not receive IRB approval, so did not start","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study did not start due to investigator time constraints","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study did not start.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study discontinued after Part A due to Sponsor's discretion.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study discontinued based on planned interim analysis of the primary endpoint. 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Superseded by NCT02973893 VF00102.","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study drug administration discontinued based on benefit-risk profile.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study drug currently unavailable","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study drug expiry date not extended","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study drug is no longer supplied by grantor.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study drug supplier withdrew support for the study. Study was withdrawn from the Duke IRB.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study early terminated due to lower drug exposure","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study 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The 3 participants at time of termination transferred into study P04538 (NCT00727077). See NCT00727077 for details\/results.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study halted on Korean PI request, to await ACIP evaluation of febrile seizure reports and final CDC recommendation regarding product useage\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study halted prematurely and will not resume; participants are no longer being examined or\u00ca receiving intervention.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Study halted prematurely due to COVID-19 but potentially will resume","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study halted prematurely due to COVID-19 but potentially will resume.","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study halted prematurely, prior to enrollment of first participant.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study has been completed","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study has been completed as planned","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study has been halted after completing Stage 1, for corporate reasons. No future patients will be enrolled or treated.\"","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study has been suspended due to reconsideration of study design.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Study has been temporarily suspended due to funding issues.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study has been terminated due low recruitment of participant population.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study has been terminated due to lack of accrual.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study has been terminated due to logistical barriers to cell processing.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study has been terminated due to poor accrual.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study has been terminated early due to financial constraints.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study has been terminated. Interim analysis results showed evidence of safety without efficacy of ODSH in patients with acute exacerbation of COPD.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study has been termination early due to financial constraints.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study has been termination early due to financial contraints.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study has never started","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study has now been terminated due to changes in project strategy. 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data analysis are completed","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study is currently Lapsed","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study is hold for analysis to date.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study is no longer funded.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study is now terminated due to technical difficulties with administration of study drug in this patient population with this schedule","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study is prematurely ended due to poor patient recruitment rate.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study is replaced by MI-CP198 per CPM.","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study is temporarily suspended due to COVID-19","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study is withdrawn due to unavailability of eligible subject population. 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measurements\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Study never initiated.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study never 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started.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study never started. Study suspended indefinitely.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study never submitted to IND. Study is being sponsored by Johnson and Johnson in the EU only.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study not being conducted","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study not initiated","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study not started","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study not yet started. Decided not to do the study. 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Future plans to be determined.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Study treatment and recruitment has been paused due to COVID-19.","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Study was administratively withdrawn by the IRB; no subjects were 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sponsor","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated early because the first phase didn't meet the endpoint.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated early due to a lack of efficacy","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated early due to lack of study feasibility and poor patient recruitment","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated early due to slow accrual.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated early due to slow patient accrual.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated early due to slow recruitment","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated for administrative reasons not related to safety or efficacy","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated for expired continuing review","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated for futility by sponsor after a pre-planned interim review of data","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated for futility on 11\/30\/09 based on the recommendation of the DSMB","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated for futility reasons.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated for lack of enrollment","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated for lack of resources to complete.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated for safety reasons","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated for site documentation and monitoring issues - not safety, study drug, or adverse event issues.\"","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated in lieu of similar,competing large, multi-site study.\"","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated in view of the C107 findings demonstrating efficacy at doses of 90 and 30 minutes","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated to financial cut","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated to focus on comparable trial, CLOMDS02507\"","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated, new protocol to be developed\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated: No longer recruiting.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated: Test article, Omontys, was recalled from the market; Enrollment has halted\u00ca prematurely and will not resume; participants are no longer being treated","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated: We are no longer recruiting.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated: recruiting or enrolling participants has halted and will not resume because low protein diet is not feasible nor efficious.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated: recruiting or enrolling participants has halted prematurely","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terminated: recruiting or enrolling participants has halted.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Termination Date: 30Aug2018; Reason for termination: Lack of Efficacy","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Termination date was 20-Oct-2008. Subjects were monitored during the post treatment 90 day follow-up period (per protocol) resulting in LPLV 19-Jan-2009.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Termination due to poor accrual.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Termination is due to a combination of a device defect potentially impacting the quality of the AD 923 IMP and a major change in corporate strategy.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Termination of study due to low enrollment. There were no safety issues.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Termination of study was due to safety reasons","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Termininated for business reasons","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Terms for legal agreements between institution and Sponsor could not be made.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The 001 trial did not show benefit versus placebo","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The 20070201 study was terminated based on evaluation of Palifermin solid tumor data.","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The 2008-09 North American peak influenza season ended prior to study completion.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The CARE Network DSMB recommended to the NHLBI that the MARS trial be terminated, based on a futility analysis with 55 randomized children.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The CIHR Financial support was withdrawn because of insufficient recruitment","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The Clinical Development Program for MGCD0103 is being re-evaluated","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The Co-Principal Investigator has moved and is no longer interested in continuing this study at this site.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"The DMC detected an imbalance in safety outcomes between the two groups.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The DMC terminated the study on the basis of futility (insufficient clinical response).","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The DSMB recommended stopping the study due to safety concerns.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The DSMB recommended that the study be stopped as a result of concerns regarding safety and intolerability and insufficient evidence of efficacy.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The DSMB stopped the trial due to unacceptable side effects in the experimental arm which has \u00ca not yet been verified","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The DSMB supported termination of the trial due to slow recruitment.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The European Medical Agency granted a Paediatric Investigational Product-specific waiver on the\u00ca grounds that idelalisib is likely to be unsafe in paediatrics","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The FDA IND application is paused due to additional required testing. The IRB protocol was closed prior to research starting.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The FDA changed the labeling for this agent, and we felt we could not offer it to patients on a non-surgical study.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"The Hospital had the Unit of Stem cells Tranplantion suspended","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The IRB considered our trial risky. Although there were debates between investigators and IRB,\u00ca we terminated our trial in accordance with the suggestion of IRB.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":true,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The Investigator-Coordinator has moved to Rennes University Hospital. It will be done under the\u00ca sponsor of Rennes University Hospital : NCT03686306","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"The NHLBI BSMB recommended closure due to poor enrollment.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The Omega arm of this study was stopped for futility. The EDEN arm continues to recruit patients as a separate independent study.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The PI has determined not to continue the study.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The PI has elected to terminate study at this time","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The PI is currently completing a fellowship out of state. Upon completion of fellowship, PI plans to continue recruitment for study.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"The PI is no longer with Kentuckiana Cancer Institute. All current subjects completed. No further subjects will be enrolled. Terminated with IRB.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"The PI left the institution.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"The PI moved to another city and position","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"The PI, who was sponsor got retired","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"The Principal Investigator is no longer affiliated with the Study Site.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"The Principal Investigator left Columbia University and chose not to re-initiate the study at new facility","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"The Principal Investigator left the clinic and there was no one who could take over this study.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"The Sponsor (Amicus Therapeutics) terminated this study for logistical reasons.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The Study was terminated on May 24th 2012 due to a slow recruitment rate. The study was not\u00ca terminated for reasons of safety or efficacy.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The Trial could not get permit from Department of Health, Taiwan; Furthermore, no research fund could support the expensive (photosensitizer) photosan\"","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The VA IRB would not allow demented subjects to be entered in this study.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":true,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The accrual rate was not high enough to reach the target sample size.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The biological effect seen with natalizumab was not sufficient to warrant further development in RA.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The biological effect seen with natalizumab was not sufficient to warrant further development\u00ca in RA.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The buccal arm of the study was 30% less effecrtive in stopping seizures within 10 minutes compared with the IV dose. This met a stoppimg rule for the study","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The clinical study has been terminated based on difficulties to enroll eligible subjects per protocol inclusion and exclusion criteria.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The clinical use of Campath for transplant patients was temporarily suspended.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"The company providing study IMP was unable to supply further batches of IMP.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The compound has a benign safety profile with short-term use, clinically sig efficacy responses have not been demonstrated, or if so, have not been sustained.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The correlation coefficient at the interim analysis with results for all three groups pooled,\u00ca did not reach the level of statistical significance of (p<0.05).","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The data available is enough for the publication and the study article published in Middle East Journal of Anesthesiology.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true},{"text":"The decision is based on company re-evaluation of indications to be pursued within SCCHN","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The decision of terminate the study was reached due to difficulties surrounding recruitment and enrollment of subjects since the inception of the study.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The decision to close the NN2211-3619 trial was based on the very low recruitment rate as well\u00ca as challenges relating to trial execution and study completion.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"The decision to stop the trial was based on efficacy results in the overall schizophrenia\u00ca patient population.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The decision to terminate this study after 202 mg\/m2 cohort was taken as MTD achieved in other study at 185 mg\/m2","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The decision to terminate was completely related to efficacy and there were no safety concerns.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The decision to terminate was for administrative reasons; there were no safety or efficacy concerns.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The development program has been terminated","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The differences seen between treatments led to recalculation of the sample, unattainable in a reasonable time","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"The doses were not effective in maintaining testosterone suppression","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The drug company sponsor has withdrawn support.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The drug needed for the study is not available in Mexico anymore.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The enrollment is slower than expected","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The epidemic of COVID-19 has been controlled well at present, no eligible patients can be","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The epidemic of COVID-19 has been controlled well in China, no eligible patients can be","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The ethics committee did not approve the pharmacokinetic part of the study.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":true,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The exclusion criteria were stringent and enrollment was slow.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The final assessments were conducted late and in a reduced format due to resource limitations\u00ca at the site.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The grant application for this project was rejected.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The grant for this project wasn't funded, so there has been no enrollment. We are still hopeful\u00ca that the project will go forward some day, but not now.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The hypothesis that probiotics would reduce hepatic steatosis in humans was not supported","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The incidence of post-operative delirium observed from interim blinded data in DEX-06-09 was significantly lower than the current literature in this population.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true},{"text":"The incidence of post-operative delirium observed from interim blinded data was significantly lower than the current literature in this population.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true},{"text":"The intervention could not be successfully carried out in the SADP setting because of issues independent of the cognitive training intervention.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"The introduction of oral propranolol as a highly efficacious agent for infantile hemangiomas","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The investigational drug is unlikely to demonstrate efficacy over placebo for this indication. \u00ca However, no safety issues were discovered.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The investigator at Cedars stopped this study due to problems collecting payment from the sponsor.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The investigators left the institution.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"The investigators were not able to get grant funding for this study.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The laboratory's partner on this study decides to terminate the contract with the CHRU Brest,\u00ca because of the difficulty of the recruitment.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The last remaining subject withdrew consent because the collaborator Genentech stopped\u00ca supplying study drug.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The low accrual rate of the study (25% of the expected accrual rate)","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The maintenance doses were too low to maintain testosterone suppression","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The major and primary reason for the study termination is the observed reduced efficacy of CellCept compared to placebo.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The manufacturer decided to halt manufacturing the vaccine","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The manufacturer discontinued necessary reagents.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The number of enrolled subjects did not meet the goal during the study","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The number of participants needed for this study has been met.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The number of patients desired has been reached","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The number of successes is not reached at the end of first stage of the phase II. The study is\u00ca stopped.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The number of the anticipated participants was not achieved","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The numbers of drop-out patients are more than we anticipate","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"The original PI, Alexander Neumeister, left NYULMC. No data was analyzed.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"The orthopedic surgeon that does our knee surgeries has moved to a different location.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"The overall profile does not support development for obesity","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The patient population changed. Unable to find patients that meet study criteria","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The patient population was not enough to complete enrollment","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The pharmaceutical company discontinued further development of SU5416.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The phase II portion was not conducted due to funding issue.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The planned enrollment was 130 patients and the study was halted prematurely due to lack of efficacy in both arms. Enrolled patients continued treatment.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The planned enrollment was 130 patients and the study was halted prematurely due to lack of \u00ca efficacy in both arms. Enrolled patients continued treatment.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"The predecessor study A00309 (NCT00152464) did not show statistical significance in time to onset of asthma between the levocetirizine and placebo groups.","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The preliminary data do not support the expected sustainable blood levels of triptorelin for a duration of 4 months in all patients.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The premature end of this trial was a business decision and not due to safety or efficacy concerns of the compounds.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The present study was joining 2005-41-4933 into one study","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The program responsible for recruitment was dismantled in 2006.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The protocol finished.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The reason for the discontinuation of the study is difficulty with recruitment and timely\u00ca enrolment and is not related to safety concerns","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The recent outbreak and in anticipation of further spread of COVID-19, to protect the health","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The recruitment rate for the study was inadequate to achieve its enrollment goals.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The recruitment rate slowed considerably","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The recruitment rate was much slower than expected.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The recruitment rate was too slow according to study protocol and agreement.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The required results were obtained through alternate methodology","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The research project has been cancelled before any participants were enrolled.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The researcher had left the hospital and the project was stopped","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"The response rate (5\/8) had reached a statistical significant endpoint.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true},{"text":"The response rate observed in the phase 1 portion of the study did not merit further evaluation\u00ca in phase 2 portion of the study.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The results from the interim analysis were not favorable to continue this trial.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The results obtained 1 year after surgery were clearly indicative of the outcome and the investigators decided to terminate follow-up at that point.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The results obtained 1 year after surgery were clearly indicative of the outcome and the \u00ca investigators decided to terminate follow-up at that point.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The results of a same study design have shown low response with important side effects. Accordingly & ethicly, the study has been stopped.\"","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The results of the dose escalation phase did not identify a well-tolerated dose that would \u00ca permit further study in Phase 2.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"The results of this study will not be published due to the large number of losses to follow-up, which affected the results.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The results were not able to be consistantly reproduced. Thus the trial was terminated","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The risk-benefit ratio for patients has changed since we initiated the study, and that the\u00ca study in its current form cannot be justified","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The risk-benefit ratio for the use of onercept in this condition was not sufficiently \u00ca favorable to justify continued development","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The safety profile of combination therapy became unacceptable.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The scientific commitee decided to stop the inclusions and exploit the results.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The site decided to stop the study","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The site is unable to recruit patients.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"The sponsor decided to stop the study prematurely because of financial issues","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The sponsor decided to terminate the study due to slow enrollment.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The sponsor determined that adequate data had been acquired.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The sponsor did not provide the 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(W.J. 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[hypersensitivity].","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The study was cancelled before any patients were enrolled, due to operational reasons.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The study was cancelled due to budget 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recruitment.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The study was discontinued prematurely on 25 February 2008 due to slow enrollment","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The study was discontinued prematurely on December 18 2008 due to slow 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terminated due to poor enrollment.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The study was terminated due to poor feasibility and lack of interest at the participating\u00ca sites.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"The study was terminated due to results in another study (NCT00878501).","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The study was terminated due to slow accrual.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The study was terminated due to the inability to enroll 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There were no safety\/efficacy concerns behind the decision.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The study was terminated on June 25th, 2009 due to strategic decision","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The study was terminated on June 25th, 2009 due to strategic decision\"","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The study was terminated on the basis of futility. 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Limited availability of alternative rescue medication severly impacted timelines","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The trial has been terminated due to an estimated low probability of clinical benefit based on\u00ca limited anti-leukemic effects observed in safety run-in (Part 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rates.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The trial was stopped at the first stage due to futility","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"The trial was stopped based on information from the global phase 3 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Active","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was cancelled due to lack of enrollment.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was closed due to lack of 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time.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was stopped due to slow enrollment after enrolling only 9 of 80 patients over 14 months time.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was stopped early due to slow 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patients in six \u00ca months time.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was stopped prematurely due to lack of efficacy.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was stopped to allow initiation of a mult-center study","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was suspended due to insufficient subject accrual.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was suspended for futility","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was temporarily paused due to an unanticipated bioanalytical issue.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated May 7, 2007. The study stopped due to tablet formulation issues. No safety issues were involved in the termination decision.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated at the recommendation of an independent Data Monitoring Committee. The decision was not based on any safety concerns.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated at the request of the drug manufacturer.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated based on preliminary safety data.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated because it was unlikely to have sufficient power to show a difference with therapy on an interim analysis.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated because of recruitment difficulties.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated because the drug company stopped making the study drug","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated due to low accrual.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated due to low enrollment.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated due to poor enrollment","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated due to slow enrollment, despite protocol amendments to change the entrance criteria.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated due to slow enrollment, despite protocol amendments to change the \u00ca entrance criteria.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated early as a result of regulatory action suspending tegaserod use in 2007","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated early due to lack of adequate enrollment.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated early due to poor recruitment","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated early due to poor recruitment.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated early due to slow enrollment.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated early in April 2005 due to low patient enrollment","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated early in May 2006 due to low patient enrollment","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated for administrative reasons.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated for administrative reasons. The dose ranging plan for the program was revised.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated in November 2008 due to "a business decision (resources)".","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated on January 6, 2010, due to toxicology findings in animals exposed to \u00ca PF-04455242 for three months.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated on November 20, 2003 because of poor recruitment. This study was not terminated due to safety\/efficacy.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was terminated. An IT injection study of C. novyi-NT in patients with treatment\u00ca refractory solid tumor malignancies may be viewed at NCT01924689.","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was withdrawn due to business reasons.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was withdrawn due to lack of necessary resources from the liver transplant surgical\u00ca group.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was withdrawn due to study agent availability.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was withdrawn for administrative reasons. The dose ranging plan for the program was revised".","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was withdrawn for administrative reasons. There were no safety concerns.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was withdrawn for business reasons.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study was withdrawn prior to patient enrollment","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study will not be conducted. A new study is replacing this one.","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This study will not be initiated. Study will be conducted with Systane Ultra in 2010.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"This study will undergo a temporarily pause in recruitment (screening and enrollment) due to\u00ca the COVID-19 pandemic.","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This trial discontinued on 2 May 2008 due to lack of enrolment","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This trial discontinued on 20 JUN 2008 because the interim immunogenicity results do not justify these formulations as pandemic vaccine candidates","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This trial discontinued on 30 JUN 2006 due to a lack of enrolment","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This trial is being closed based on lack of substantive efficacy, slow accrual and overall tolerance in patients treated to date.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This trial is being closed based on lack of substantive efficacy, slow accrual and overall\u00ca tolerance in patients treated to date.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This trial was never initiated due to inability to obtain the device","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This trial was supporting the development of an asset which was terminated, thus the data from\u00ca the study were no longer required.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This was a follow-on study to Biomed 777-CLP-029 which did not meet superiority endpoint","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"This was an inpatient study, but PI left inpatient service at MGH","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false},{"text":"Tightly defined inclusion criteria were making recruitment very slow.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Time constraints","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Time to engraftment would not be improved compared to historical controls.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"To conserve remaining capital, Sponsor decided to terminate the study early.\"","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"To difficult to recruit patients in the acute setting","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"To few included patients","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"To focus on another clinical 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indications","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Too few inclusions","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Too few patients completed the study once 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cases)","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Unacceptable incidence of wound dehiscence in the PDS group","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Unavailability of clarithromycin 250 mg in the market","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Unavailability of investigational product","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Unavailability of study 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Study drug expired","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Unexpected safety events.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Unexpected side-effects: reversible and mild to moderate neurological impairment","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Unexpected withdrawal of funding","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Unexpectedely high rates of treatment-failure","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Unfavourable Pharmakokinetics","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Unforeseen difficulty identifying and enrolling eligible subjects","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Unfortunately we had unforeseen difficulty recruiting to this study. Therefore we have decided to halt the study and not publish the results.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Unfortunately, other Phase III clinical Study (GEM+S-1 vs GEM vs S-1) have been started in Japan.\"","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"UniQure, has decided not to renew the Marketing Authorization of Glybera in the EU. This\u00ca decision is not related to any safety, efficacy or quality issue","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Unknown","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Unplanned interim analysis by DSMB indicated possible reduced response rate with the addition of Ca\/Mg in pooled population. 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expected","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Very difficult to recruit patients\/slow recruitment(2 patients in nearly 2 years).","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Very low rate of recruitment anticipated futility of pursuing the 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rate","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Very poor enrollment","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Very poor recruitment in the Part 4 of the 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care","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Voluntarily closed and terminated by the PI due to lack of feasibility","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Voluntarily terminated based on preliminary non-clinical findings.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Voluntary halt of further dosing due to an FDA Clinical Hold issued in relation to Dynavax study DV2-HBV-10","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Voluntary suspension due to substantial study updates and COVID-19","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Waiting for FDA approval of IND","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Was not able to recruit enough patients","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Was unable to accrue any patients","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"We are awaiting publication of the Erythropoietin in Acute Ischemic Stroke Study(NCT00604630).","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"We believe regional anesth better for TKR,90% patients got epidural. Last year we started spinal morphine one shot, and found it very promissing.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"We can't obtained the test drug (Vadenafil) from Bayer. They decided not to carry out this trail in Taiwan. Therefore this trail has never been started.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"We closed the study to further enrollment based on the lack of perceived need for domperidone in this population.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"We could not get funding for study.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"We could not receive the support from the national medical insurance owing to the changed\u00ca policy of the government for clincal trials.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"We decided that the study would not substantially add to existing contributions in the literature","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"We decided to enroll patients via e-mail rather than via telephone and are waiting for the hospital registration system to be updated with patients' e-mail.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"We determined that the results would not be worth reporting.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"We did not achieve a tolerogenic profile. Subjects withdrew from protocol and enrolled in\u00ca other islet transplant trials.","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"We did not see any effect of Palifermin on benign or malignant tumor growth","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"We didn't use this tech in patient.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"We didnt recieved the medicine","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"We encounter technical problems to continue with the study. (Notably difficulty in teaching the patients to use the dressing set involved in the study.)","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"We failed to recruit patients","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"We found out that there is another study on the same issue","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"We had got enough data, therefore we stopped the study and published the data.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"We had to suspend our clinical trials due to the pandemic of COVID-19.","Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"We have decided to cancel this study.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"We have recruited 16 subjects for the pilot study. The recruitment will resume once the amendments are approved for increasing sample size to 30 subjects.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"We need to make significant adjustments to proposed drug and its delivery method","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"We strongly feel that the ability to recruit the required number of patients is very low and\u00ca thus decided to stop the study.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"We were unable to enroll a sufficient number of patients due to manpower.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"We were unable to procure the supplement for this study.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"We were unable to receive IVIG free from phamaceutical company.","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"We were unable to recruit sufficient patients within the confines of our budget","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"We wish to wait until there is more data available using this substance.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"When 9 subjects of targeted 12 subjects had been studied, no changes in plasma potassium were detected and it was deemed futile to continue with enrolment.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"When used appear DNE3 toxic properties. The DSMB determined that due to higher than expected \u00ca risk and safety concerns the study should be closed.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"While the GBT440 IPF results noted an improvement in oxygen saturation, they did not translate\u00ca into a clinically meaningful benefit.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Will study new T-cell construct for the same indication","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Withdrawal of drug supply.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Withdrawal of marketing autorization of efalizumab by the EMEA.","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Withdrawal of pharmaceutical company support for the investigational drug","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Withdrawal of pharmaceutical support from Novartis","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Withdrawn (No Participants Enrolled)","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Withdrawn - due to lack of accrual","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Withdrawn as NCI rescinded approval for parent study NSABP-B-45","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Withdrawn as company has shut down and filed for bankruptcy","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Withdrawn as early analysis indicated stereotactic radiosurgery not as beneficial post-op as pre-op","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Withdrawn as study has been abandoned","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Withdrawn as study never opened","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Withdrawn as the clinical development of ATN-224 was terminated by the drug company who was providing ATN-224 for the study","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Withdrawn as the sponsor has stopped the drug for NSCLC population","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Withdrawn as trial was never activated by SuperGen","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Withdrawn as was replaced by another study","Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Withdrawn because Ablatherm devices were not available anymore at trial centers","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Withdrawn because of lack of aprovement from local medical authorities","Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Withdrawn because of personal ressources before inclusion of the first patient","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Withdrawn because protocol has been discontinued. 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The data are not interpretable in terms of efficacy.\"","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false},{"text":"Withdrawn because treatment guidelines changed","Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false},{"text":"Withdrawn by 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