sentence1: GATA2 is also of considerable interest; genetic ablation leads to tumor regression in mouse models of adenocarcinoma of the lung, and whereas this transcription factor may appear to be the least druggable of targets, its role in regulating the proteasome suggested therapeutic approaches that appear very promising
sentence2: The GATA2 transcription factor, which is essential for oncogenic K-ras-dependent lung tumor development, binds to the TRAF6 promoter and enhances its expression.