sentence1: Recent in vitro studies using shRNA-based approaches have suggested a role for TET2 in regulating myeloid differentiation and in regulating stem/progenitor cell proliferation.
sentence2: Two recent studies used RNAi-mediated Tet2 knock-down in vitro to suggest that TET2 depletion led to impaired hematopoietic differentiation and to preferential myeloid commitment.