sentence1: Importantly, RNAi knockdown of Gfpt1 reduced overall O-GlcNAcylation and blocked KrasG12DA-mediated tumor growth in vitro and in vivo.
sentence2: GFPT1 is the rate-limiting enzyme in the HBP and it has been identified as an important contributor to Kras-driven pancreatic ductal adenocarcinoma (PDAC)