Initial version
Browse files- LICENSE +201 -0
- README.md +104 -0
- configs/inference.yaml +149 -0
- configs/logging.conf +21 -0
- configs/metadata.json +62 -0
- configs/train.yaml +223 -0
- docs/README.md +97 -0
- docs/data_license.txt +24 -0
- docs/examples/008501_fixed_7.png +0 -0
- docs/examples/008502_fixed_6.png +0 -0
- docs/examples/008502_moving_6.png +0 -0
- docs/examples/008502_pred_6.png +0 -0
- docs/examples/008504_moving_7.png +0 -0
- docs/examples/008504_pred_7.png +0 -0
- models/model.pt +3 -0
- scripts/__init__.py +10 -0
- scripts/net.py +42 -0
LICENSE
ADDED
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README.md
ADDED
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---
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tags:
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- monai
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- medical
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library_name: monai
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license: apache-2.0
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---
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# MedNIST Hand Image Registration
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+
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Based on [the tutorial of 2D registration](https://github.com/Project-MONAI/tutorials/tree/main/2d_registration)
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## Downloading the Dataset
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Download the dataset [from here](https://github.com/Project-MONAI/MONAI-extra-test-data/releases/download/0.8.1/MedNIST.tar.gz) and extract the contents to a convenient location.
|
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|
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The MedNIST dataset was gathered from several sets from [TCIA](https://wiki.cancerimagingarchive.net/display/Public/Data+Usage+Policies+and+Restrictions),
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[the RSNA Bone Age Challenge](http://rsnachallenges.cloudapp.net/competitions/4),
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and [the NIH Chest X-ray dataset](https://cloud.google.com/healthcare/docs/resources/public-datasets/nih-chest).
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+
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The dataset is kindly made available by [Dr. Bradley J. Erickson M.D., Ph.D.](https://www.mayo.edu/research/labs/radiology-informatics/overview) (Department of Radiology, Mayo Clinic)
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under the Creative Commons [CC BY-SA 4.0 license](https://creativecommons.org/licenses/by-sa/4.0/).
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+
|
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If you use the MedNIST dataset, please acknowledge the source.
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23 |
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## Training
|
25 |
+
|
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Training with same-subject image inputs
|
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```bash
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python -m monai.bundle run training --config_file configs/train.yaml --dataset_dir "/workspace/data/MedNIST/Hand"
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```
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+
|
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Training with cross-subject image inputs
|
32 |
+
```bash
|
33 |
+
python -m monai.bundle run training \
|
34 |
+
--config_file configs/train.yaml \
|
35 |
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--dataset_dir "/workspace/data/MedNIST/Hand" \
|
36 |
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--cross_subjects True
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```
|
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|
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Training from an existing checkpoint file, for example, `models/model_key_metric=-0.0734.pt`:
|
40 |
+
```bash
|
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+
python -m monai.bundle run training --config_file configs/train.yaml [...omitting other args] --ckpt "models/model_key_metric=-0.0734.pt"
|
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```
|
43 |
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|
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## Inference
|
45 |
+
|
46 |
+
The following figure shows an intra-subject (`--cross_subjects False`) model inference results (Fixed, moving and predicted images from left to right)
|
47 |
+
|
48 |
+
![fixed](./examples/008502_fixed_6.png)
|
49 |
+
![moving](./examples/008502_moving_6.png)
|
50 |
+
![predicted](./examples/008502_pred_6.png)
|
51 |
+
|
52 |
+
The command shows an inference workflow with the checkpoint `"models/model_key_metric=-0.0890.pt"` and using device `"cuda:1"`:
|
53 |
+
```bash
|
54 |
+
python -m monai.bundle run eval \
|
55 |
+
--config_file configs/inference.yaml \
|
56 |
+
--ckpt "models/model_key_metric=-0.0890.pt" \
|
57 |
+
--logging_file configs/logging.conf \
|
58 |
+
--device "cuda:1"
|
59 |
+
```
|
60 |
+
|
61 |
+
## Fine-tuning for cross-subject alignments
|
62 |
+
|
63 |
+
The following commands starts a finetuning workflow based on the checkpoint `"models/model_key_metric=-0.0065.pt"`
|
64 |
+
for `5` epochs using the global mutual information loss.
|
65 |
+
|
66 |
+
```bash
|
67 |
+
python -m monai.bundle run training \
|
68 |
+
--config_file configs/train.yaml \
|
69 |
+
--cross_subjects True \
|
70 |
+
--ckpt "models/model_key_metric=-0.0065.pt" \
|
71 |
+
--lr 0.000001 \
|
72 |
+
--trainer#loss_function "@mutual_info_loss" \
|
73 |
+
--max_epochs 5
|
74 |
+
```
|
75 |
+
The following figure shows an inter-subject (`--cross_subjects True`) model inference results (Fixed, moving and predicted images from left to right)
|
76 |
+
|
77 |
+
![fixed](./examples/008501_fixed_7.png)
|
78 |
+
![moving](./examples/008504_moving_7.png)
|
79 |
+
![predicted](./examples/008504_pred_7.png)
|
80 |
+
|
81 |
+
## Visualize the first pair of images for debugging (requires `matplotlib`)
|
82 |
+
|
83 |
+
```bash
|
84 |
+
python -m monai.bundle run display --config_file configs/train.yaml
|
85 |
+
```
|
86 |
+
|
87 |
+
```bash
|
88 |
+
python -m monai.bundle run display --config_file configs/train.yaml --cross_subjects True
|
89 |
+
```
|
90 |
+
|
91 |
+
# License
|
92 |
+
Copyright (c) MONAI Consortium
|
93 |
+
|
94 |
+
Licensed under the Apache License, Version 2.0 (the "License");
|
95 |
+
you may not use this file except in compliance with the License.
|
96 |
+
You may obtain a copy of the License at
|
97 |
+
|
98 |
+
http://www.apache.org/licenses/LICENSE-2.0
|
99 |
+
|
100 |
+
Unless required by applicable law or agreed to in writing, software
|
101 |
+
distributed under the License is distributed on an "AS IS" BASIS,
|
102 |
+
WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
|
103 |
+
See the License for the specific language governing permissions and
|
104 |
+
limitations under the License.
|
configs/inference.yaml
ADDED
@@ -0,0 +1,149 @@
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
+
---
|
2 |
+
imports:
|
3 |
+
- $import glob
|
4 |
+
- $import matplotlib.pyplot as plt
|
5 |
+
dataset_dir: "../MedNIST/Hand"
|
6 |
+
# inference with 10 images, modify the indices to run it with different image inputs
|
7 |
+
datalist: "$list(sorted(glob.glob(@dataset_dir + '/*.jpeg')))[8500:8510]"
|
8 |
+
|
9 |
+
bundle_root: "./"
|
10 |
+
device: "$torch.device('cuda:0' if torch.cuda.is_available() else 'cpu')"
|
11 |
+
output_dir: "$@bundle_root + '/eval'"
|
12 |
+
ckpt: "$@bundle_root + '/models/model.pt'"
|
13 |
+
cross_subjects: false # whether the input images are from the same subject
|
14 |
+
|
15 |
+
image_load:
|
16 |
+
- _target_: LoadImage
|
17 |
+
image_only: True
|
18 |
+
ensure_channel_first: True
|
19 |
+
|
20 |
+
- _target_: ScaleIntensityRange
|
21 |
+
a_min: 0.0
|
22 |
+
a_max: 255.0
|
23 |
+
b_min: 0.0
|
24 |
+
b_max: 1.0
|
25 |
+
|
26 |
+
- _target_: EnsureType
|
27 |
+
device: "@device"
|
28 |
+
|
29 |
+
image_aug:
|
30 |
+
- _target_: RandAffine
|
31 |
+
spatial_size: [64, 64]
|
32 |
+
translate_range: 5
|
33 |
+
scale_range: [-0.15, 0.15]
|
34 |
+
prob: 1.0
|
35 |
+
rotate_range: $np.pi / 8
|
36 |
+
mode: bilinear
|
37 |
+
padding_mode: border
|
38 |
+
cache_grid: True
|
39 |
+
device: "@device"
|
40 |
+
|
41 |
+
preprocessing:
|
42 |
+
_target_: Compose
|
43 |
+
transforms: "$@image_load + @image_aug"
|
44 |
+
|
45 |
+
datasets:
|
46 |
+
- _target_: ShuffleBuffer
|
47 |
+
data:
|
48 |
+
_target_: Dataset
|
49 |
+
data: "@datalist"
|
50 |
+
transform: {_target_: Compose, transforms: "@image_load"}
|
51 |
+
seed: "$int(3) if @cross_subjects else int(2)"
|
52 |
+
- _target_: ShuffleBuffer
|
53 |
+
data:
|
54 |
+
_target_: Dataset
|
55 |
+
data: "@datalist"
|
56 |
+
transform: $@preprocessing.set_random_state(3)
|
57 |
+
seed: 2
|
58 |
+
|
59 |
+
zip_dataset:
|
60 |
+
_target_: IterableDataset
|
61 |
+
data: "$map(lambda t: dict(image=monai.transforms.concatenate(t), m_img=t[0], label=t[1]), zip(*@datasets))"
|
62 |
+
|
63 |
+
data_loader:
|
64 |
+
_target_: ThreadDataLoader
|
65 |
+
dataset: "@zip_dataset"
|
66 |
+
batch_size: 1
|
67 |
+
num_workers: 0
|
68 |
+
|
69 |
+
|
70 |
+
# components for debugging
|
71 |
+
first_pair: $monai.utils.misc.first(@data_loader)
|
72 |
+
display:
|
73 |
+
- $monai.utils.set_determinism(seed=23)
|
74 |
+
- $print(@first_pair.keys())
|
75 |
+
- $plt.subplot(1,3,1)
|
76 |
+
- $plt.imshow(@first_pair['image'][0, 0], cmap="gray")
|
77 |
+
- $plt.subplot(1,3,2)
|
78 |
+
- $plt.imshow(@first_pair['image'][0, 1], cmap="gray")
|
79 |
+
- $plt.subplot(1,3,3)
|
80 |
+
- $plt.imshow(np.abs(@first_pair['image'][0, 0] - @first_pair['image'][0, 1]), cmap="gray")
|
81 |
+
- $plt.show()
|
82 |
+
|
83 |
+
# network definition
|
84 |
+
network_def:
|
85 |
+
_target_: scripts.net.RegResNet
|
86 |
+
image_size: [64, 64]
|
87 |
+
spatial_dims: 2
|
88 |
+
mode: "bilinear"
|
89 |
+
padding_mode: "border"
|
90 |
+
|
91 |
+
# create the primary evaluator
|
92 |
+
handlers:
|
93 |
+
- _target_: CheckpointLoader
|
94 |
+
load_path: "@ckpt"
|
95 |
+
load_dict: {model: "@network_def"}
|
96 |
+
- _target_: StatsHandler
|
97 |
+
iteration_log: false
|
98 |
+
|
99 |
+
inferer: {_target_: SimpleInferer}
|
100 |
+
|
101 |
+
evaluator:
|
102 |
+
_target_: SupervisedEvaluator
|
103 |
+
device: "@device"
|
104 |
+
val_data_loader: "@data_loader"
|
105 |
+
network: "@network_def"
|
106 |
+
epoch_length: $len(@datalist) // @data_loader#batch_size
|
107 |
+
inferer: "@inferer"
|
108 |
+
val_handlers: "@handlers"
|
109 |
+
postprocessing:
|
110 |
+
_target_: Compose
|
111 |
+
transforms:
|
112 |
+
- _target_: SaveImaged
|
113 |
+
keys: [m_img]
|
114 |
+
resample: False
|
115 |
+
output_dir: "@output_dir"
|
116 |
+
output_ext: "png"
|
117 |
+
output_postfix: "moving"
|
118 |
+
output_dtype: "$np.uint8"
|
119 |
+
scale: 255
|
120 |
+
separate_folder: False
|
121 |
+
writer: "PILWriter"
|
122 |
+
output_name_formatter: "$lambda x, s: dict(idx=s._data_index, subject=x['filename_or_obj'])"
|
123 |
+
- _target_: SaveImaged
|
124 |
+
keys: [label]
|
125 |
+
resample: False
|
126 |
+
output_dir: "@output_dir"
|
127 |
+
output_ext: "png"
|
128 |
+
output_postfix: "fixed"
|
129 |
+
output_dtype: "$np.uint8"
|
130 |
+
scale: 255
|
131 |
+
separate_folder: False
|
132 |
+
writer: "PILWriter"
|
133 |
+
output_name_formatter: "$lambda x, s: dict(idx=s._data_index, subject=x['filename_or_obj'])"
|
134 |
+
- _target_: SaveImaged
|
135 |
+
keys: [pred]
|
136 |
+
resample: False
|
137 |
+
output_dir: "@output_dir"
|
138 |
+
output_ext: "png"
|
139 |
+
output_postfix: "pred"
|
140 |
+
output_dtype: "$np.uint8"
|
141 |
+
scale: 255
|
142 |
+
separate_folder: False
|
143 |
+
writer: "PILWriter"
|
144 |
+
output_name_formatter: "$lambda x, s: dict(idx=s._data_index, subject=x['filename_or_obj'])"
|
145 |
+
|
146 |
+
eval:
|
147 |
+
- $monai.utils.set_determinism(seed=123)
|
148 |
+
- "$setattr(torch.backends.cudnn, 'benchmark', True)"
|
149 |
+
- $@evaluator.run()
|
configs/logging.conf
ADDED
@@ -0,0 +1,21 @@
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
+
[loggers]
|
2 |
+
keys=root
|
3 |
+
|
4 |
+
[handlers]
|
5 |
+
keys=consoleHandler
|
6 |
+
|
7 |
+
[formatters]
|
8 |
+
keys=fullFormatter
|
9 |
+
|
10 |
+
[logger_root]
|
11 |
+
level=INFO
|
12 |
+
handlers=consoleHandler
|
13 |
+
|
14 |
+
[handler_consoleHandler]
|
15 |
+
class=StreamHandler
|
16 |
+
level=INFO
|
17 |
+
formatter=fullFormatter
|
18 |
+
args=(sys.stdout,)
|
19 |
+
|
20 |
+
[formatter_fullFormatter]
|
21 |
+
format=%(asctime)s - %(name)s - %(levelname)s - %(message)s
|
configs/metadata.json
ADDED
@@ -0,0 +1,62 @@
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
+
{
|
2 |
+
"schema": "https://github.com/Project-MONAI/MONAI-extra-test-data/releases/download/0.8.1/meta_schema_20220324.json",
|
3 |
+
"version": "0.0.1",
|
4 |
+
"changelog": {
|
5 |
+
"0.0.1": "Initial version"
|
6 |
+
},
|
7 |
+
"monai_version": "1.0.1",
|
8 |
+
"pytorch_version": "1.13.0",
|
9 |
+
"numpy_version": "1.22.2",
|
10 |
+
"optional_packages_version": {
|
11 |
+
"pytorch-ignite": "0.4.8"
|
12 |
+
},
|
13 |
+
"task": "Spatial transformer for hand image registration from the MedNIST dataset",
|
14 |
+
"description": "This is an example of a ResNet and spatial transformer for hand xray image registration",
|
15 |
+
"authors": "MONAI team",
|
16 |
+
"copyright": "Copyright (c) MONAI Consortium",
|
17 |
+
"intended_use": "This is an example of image registration using MONAI, suitable for demonstration purposes only.",
|
18 |
+
"data_type": "jpeg",
|
19 |
+
"network_data_format": {
|
20 |
+
"inputs": {
|
21 |
+
"image": {
|
22 |
+
"type": "image",
|
23 |
+
"format": "magnitude",
|
24 |
+
"num_channels": 2,
|
25 |
+
"spatial_shape": [
|
26 |
+
64,
|
27 |
+
64
|
28 |
+
],
|
29 |
+
"dtype": "float32",
|
30 |
+
"value_range": [
|
31 |
+
0,
|
32 |
+
1
|
33 |
+
],
|
34 |
+
"is_patch_data": false,
|
35 |
+
"channel_def": {
|
36 |
+
"0": "moving image",
|
37 |
+
"1": "fixed image"
|
38 |
+
}
|
39 |
+
}
|
40 |
+
},
|
41 |
+
"outputs": {
|
42 |
+
"pred": {
|
43 |
+
"type": "image",
|
44 |
+
"format": "magnitude",
|
45 |
+
"num_channels": 1,
|
46 |
+
"spatial_shape": [
|
47 |
+
64,
|
48 |
+
64
|
49 |
+
],
|
50 |
+
"dtype": "float32",
|
51 |
+
"value_range": [
|
52 |
+
0,
|
53 |
+
1
|
54 |
+
],
|
55 |
+
"is_patch_data": false,
|
56 |
+
"channel_def": {
|
57 |
+
"0": "image"
|
58 |
+
}
|
59 |
+
}
|
60 |
+
}
|
61 |
+
}
|
62 |
+
}
|
configs/train.yaml
ADDED
@@ -0,0 +1,223 @@
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
+
---
|
2 |
+
imports:
|
3 |
+
- $import glob
|
4 |
+
- $import matplotlib.pyplot as plt
|
5 |
+
|
6 |
+
# workflow parameters
|
7 |
+
bundle_root: "./"
|
8 |
+
device: "$torch.device('cuda:0' if torch.cuda.is_available() else 'cpu')"
|
9 |
+
ckpt_dir: "$@bundle_root + '/models'" # folder to save new checkpoints
|
10 |
+
ckpt: "" # path to load an existing checkpoint
|
11 |
+
val_interval: 1 # every epoch
|
12 |
+
max_epochs: 300
|
13 |
+
cross_subjects: false # whether the input images are from the same subject
|
14 |
+
|
15 |
+
# construct the moving and fixed datasets
|
16 |
+
dataset_dir: "../MedNIST/Hand"
|
17 |
+
datalist: "$list(sorted(glob.glob(@dataset_dir + '/*.jpeg')))[:7000]" # training with 7000 images
|
18 |
+
val_datalist: "$list(sorted(glob.glob(@dataset_dir + '/*.jpeg')))[7000:8500]" # validation with 1500 images
|
19 |
+
|
20 |
+
image_load:
|
21 |
+
- _target_: LoadImage
|
22 |
+
image_only: True
|
23 |
+
ensure_channel_first: True
|
24 |
+
|
25 |
+
- _target_: ScaleIntensityRange
|
26 |
+
a_min: 0.0
|
27 |
+
a_max: 255.0
|
28 |
+
b_min: 0.0
|
29 |
+
b_max: 1.0
|
30 |
+
|
31 |
+
- _target_: EnsureType
|
32 |
+
device: "@device"
|
33 |
+
|
34 |
+
image_aug:
|
35 |
+
- _target_: RandAffine
|
36 |
+
spatial_size: [64, 64]
|
37 |
+
translate_range: 5
|
38 |
+
scale_range: [-0.15, 0.15]
|
39 |
+
prob: 1.0
|
40 |
+
rotate_range: $np.pi / 8
|
41 |
+
mode: bilinear
|
42 |
+
padding_mode: border
|
43 |
+
cache_grid: True
|
44 |
+
device: "@device"
|
45 |
+
|
46 |
+
- _target_: RandGridDistortion
|
47 |
+
prob: 0.2
|
48 |
+
num_cells: 8
|
49 |
+
device: "@device"
|
50 |
+
distort_limit: 0.1
|
51 |
+
|
52 |
+
preprocessing:
|
53 |
+
_target_: Compose
|
54 |
+
transforms: "$@image_load + @image_aug"
|
55 |
+
|
56 |
+
cache_datasets:
|
57 |
+
- _target_: ShuffleBuffer
|
58 |
+
data:
|
59 |
+
_target_: CacheDataset
|
60 |
+
data: "@datalist"
|
61 |
+
transform: $@preprocessing.set_random_state(123)
|
62 |
+
hash_as_key: true
|
63 |
+
runtime_cache: true
|
64 |
+
epochs: "@max_epochs"
|
65 |
+
seed: "$int(3) if @cross_subjects else int(2)"
|
66 |
+
- _target_: ShuffleBuffer
|
67 |
+
data:
|
68 |
+
_target_: CacheDataset
|
69 |
+
data: "@datalist"
|
70 |
+
transform: $@preprocessing.set_random_state(234)
|
71 |
+
hash_as_key: true
|
72 |
+
runtime_cache: true
|
73 |
+
epochs: "@max_epochs"
|
74 |
+
seed: 2
|
75 |
+
|
76 |
+
zip_dataset:
|
77 |
+
_target_: IterableDataset
|
78 |
+
data: "$map(lambda t: dict(image=monai.transforms.concatenate(t), label=t[1]), zip(*@cache_datasets))"
|
79 |
+
|
80 |
+
data_loader:
|
81 |
+
_requires_:
|
82 |
+
- $@cache_datasets[0].data.disable_share_memory_cache() # to cache on GPU
|
83 |
+
- $@cache_datasets[1].data.disable_share_memory_cache()
|
84 |
+
_target_: ThreadDataLoader
|
85 |
+
dataset: "@zip_dataset"
|
86 |
+
batch_size: 64
|
87 |
+
num_workers: 0
|
88 |
+
|
89 |
+
|
90 |
+
# components for debugging
|
91 |
+
first_pair: $monai.utils.misc.first(@data_loader)
|
92 |
+
display:
|
93 |
+
- $monai.utils.set_determinism(seed=123)
|
94 |
+
- $print(@first_pair.keys(), @first_pair['image'].meta['filename_or_obj'])
|
95 |
+
- "$print(@trainer#loss_function(@first_pair['image'][:, 0:1], @first_pair['image'][:, 1:2]))" # print loss
|
96 |
+
- $plt.subplot(1,2,1)
|
97 |
+
- $plt.imshow(@first_pair['image'][0, 0], cmap="gray")
|
98 |
+
- $plt.subplot(1,2,2)
|
99 |
+
- $plt.imshow(@first_pair['image'][0, 1], cmap="gray")
|
100 |
+
- $plt.show()
|
101 |
+
|
102 |
+
|
103 |
+
# network definition
|
104 |
+
net:
|
105 |
+
_target_: scripts.net.RegResNet
|
106 |
+
image_size: [64, 64]
|
107 |
+
spatial_dims: 2
|
108 |
+
mode: "bilinear"
|
109 |
+
padding_mode: "border"
|
110 |
+
|
111 |
+
optimizer:
|
112 |
+
_target_: torch.optim.Adam
|
113 |
+
params: $@net.parameters()
|
114 |
+
lr: 0.00001
|
115 |
+
|
116 |
+
# create a validation evaluator
|
117 |
+
val:
|
118 |
+
cache_datasets:
|
119 |
+
- _target_: ShuffleBuffer
|
120 |
+
data:
|
121 |
+
_target_: CacheDataset
|
122 |
+
data: "@val_datalist"
|
123 |
+
transform: $@preprocessing.set_random_state(123)
|
124 |
+
hash_as_key: true
|
125 |
+
runtime_cache: true
|
126 |
+
epochs: -1 # infinite
|
127 |
+
seed: "$int(3) if @cross_subjects else int(2)"
|
128 |
+
- _target_: ShuffleBuffer
|
129 |
+
data:
|
130 |
+
_target_: CacheDataset
|
131 |
+
data: "@val_datalist"
|
132 |
+
transform: $@preprocessing.set_random_state(234)
|
133 |
+
hash_as_key: true
|
134 |
+
runtime_cache: true
|
135 |
+
epochs: -1 # infinite
|
136 |
+
seed: 2
|
137 |
+
|
138 |
+
zip_dataset:
|
139 |
+
_target_: IterableDataset
|
140 |
+
data: "$map(lambda t: dict(image=monai.transforms.concatenate(t), label=t[1]), zip(*@val#cache_datasets))"
|
141 |
+
|
142 |
+
data_loader:
|
143 |
+
_requires_:
|
144 |
+
- $@val#cache_datasets[0].data.disable_share_memory_cache()
|
145 |
+
- $@val#cache_datasets[1].data.disable_share_memory_cache()
|
146 |
+
_target_: ThreadDataLoader
|
147 |
+
dataset: "@val#zip_dataset"
|
148 |
+
batch_size: 64
|
149 |
+
num_workers: 0
|
150 |
+
|
151 |
+
evaluator:
|
152 |
+
_target_: SupervisedEvaluator
|
153 |
+
device: "@device"
|
154 |
+
val_data_loader: "@val#data_loader"
|
155 |
+
network: "@net"
|
156 |
+
epoch_length: $len(@val_datalist) // @val#data_loader#batch_size
|
157 |
+
inferer: "$monai.inferers.SimpleInferer()"
|
158 |
+
metric_cmp_fn: "$lambda x, y: x < y"
|
159 |
+
key_val_metric:
|
160 |
+
val_mse:
|
161 |
+
_target_: MeanSquaredError
|
162 |
+
output_transform: "$monai.handlers.from_engine(['pred', 'label'])"
|
163 |
+
additional_metrics: {"mutual info loss": "@loss_metric#metric_handler"}
|
164 |
+
val_handlers:
|
165 |
+
- _target_: StatsHandler
|
166 |
+
iteration_log: false
|
167 |
+
- _target_: CheckpointSaver
|
168 |
+
save_dir: "@ckpt_dir"
|
169 |
+
save_dict: {model: "@net"}
|
170 |
+
save_key_metric: true
|
171 |
+
key_metric_negative_sign: true
|
172 |
+
# key_metric_filename: "model.pt"
|
173 |
+
|
174 |
+
# training handlers
|
175 |
+
handlers:
|
176 |
+
- _target_: StatsHandler
|
177 |
+
tag_name: "train_loss"
|
178 |
+
output_transform: "$monai.handlers.from_engine(['loss'], first=True)"
|
179 |
+
- _target_: ValidationHandler
|
180 |
+
validator: "@val#evaluator"
|
181 |
+
epoch_level: true
|
182 |
+
interval: "@val_interval"
|
183 |
+
|
184 |
+
loss_metric:
|
185 |
+
metric_handler:
|
186 |
+
_target_: IgniteMetric
|
187 |
+
output_transform: "$monai.handlers.from_engine(['pred', 'label'])"
|
188 |
+
metric_fn:
|
189 |
+
_target_: LossMetric
|
190 |
+
loss_fn: "@mutual_info_loss"
|
191 |
+
get_not_nans: true
|
192 |
+
|
193 |
+
ckpt_loader:
|
194 |
+
- _target_: CheckpointLoader
|
195 |
+
load_path: "@ckpt"
|
196 |
+
load_dict: {model: "@net"}
|
197 |
+
|
198 |
+
lncc_loss:
|
199 |
+
_target_: LocalNormalizedCrossCorrelationLoss
|
200 |
+
spatial_dims: 2
|
201 |
+
kernel_size: 5
|
202 |
+
kernel_type: rectangular
|
203 |
+
reduction: mean
|
204 |
+
|
205 |
+
mutual_info_loss:
|
206 |
+
_target_: GlobalMutualInformationLoss
|
207 |
+
|
208 |
+
# create the primary trainer
|
209 |
+
trainer:
|
210 |
+
_target_: SupervisedTrainer
|
211 |
+
device: "@device"
|
212 |
+
train_data_loader: "@data_loader"
|
213 |
+
network: "@net"
|
214 |
+
max_epochs: "@max_epochs"
|
215 |
+
epoch_length: $len(@datalist) // @data_loader#batch_size
|
216 |
+
loss_function: "@lncc_loss"
|
217 |
+
optimizer: "@optimizer"
|
218 |
+
train_handlers: "$@handlers + @ckpt_loader if @ckpt else @handlers"
|
219 |
+
|
220 |
+
training:
|
221 |
+
- $monai.utils.set_determinism(seed=23)
|
222 |
+
- "$setattr(torch.backends.cudnn, 'benchmark', True)"
|
223 |
+
- $@trainer.run()
|
docs/README.md
ADDED
@@ -0,0 +1,97 @@
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
+
# MedNIST Hand Image Registration
|
2 |
+
|
3 |
+
Based on [the tutorial of 2D registration](https://github.com/Project-MONAI/tutorials/tree/main/2d_registration)
|
4 |
+
|
5 |
+
## Downloading the Dataset
|
6 |
+
Download the dataset [from here](https://github.com/Project-MONAI/MONAI-extra-test-data/releases/download/0.8.1/MedNIST.tar.gz) and extract the contents to a convenient location.
|
7 |
+
|
8 |
+
The MedNIST dataset was gathered from several sets from [TCIA](https://wiki.cancerimagingarchive.net/display/Public/Data+Usage+Policies+and+Restrictions),
|
9 |
+
[the RSNA Bone Age Challenge](http://rsnachallenges.cloudapp.net/competitions/4),
|
10 |
+
and [the NIH Chest X-ray dataset](https://cloud.google.com/healthcare/docs/resources/public-datasets/nih-chest).
|
11 |
+
|
12 |
+
The dataset is kindly made available by [Dr. Bradley J. Erickson M.D., Ph.D.](https://www.mayo.edu/research/labs/radiology-informatics/overview) (Department of Radiology, Mayo Clinic)
|
13 |
+
under the Creative Commons [CC BY-SA 4.0 license](https://creativecommons.org/licenses/by-sa/4.0/).
|
14 |
+
|
15 |
+
If you use the MedNIST dataset, please acknowledge the source.
|
16 |
+
|
17 |
+
## Training
|
18 |
+
|
19 |
+
Training with same-subject image inputs
|
20 |
+
```bash
|
21 |
+
python -m monai.bundle run training --config_file configs/train.yaml --dataset_dir "/workspace/data/MedNIST/Hand"
|
22 |
+
```
|
23 |
+
|
24 |
+
Training with cross-subject image inputs
|
25 |
+
```bash
|
26 |
+
python -m monai.bundle run training \
|
27 |
+
--config_file configs/train.yaml \
|
28 |
+
--dataset_dir "/workspace/data/MedNIST/Hand" \
|
29 |
+
--cross_subjects True
|
30 |
+
```
|
31 |
+
|
32 |
+
Training from an existing checkpoint file, for example, `models/model_key_metric=-0.0734.pt`:
|
33 |
+
```bash
|
34 |
+
python -m monai.bundle run training --config_file configs/train.yaml [...omitting other args] --ckpt "models/model_key_metric=-0.0734.pt"
|
35 |
+
```
|
36 |
+
|
37 |
+
## Inference
|
38 |
+
|
39 |
+
The following figure shows an intra-subject (`--cross_subjects False`) model inference results (Fixed, moving and predicted images from left to right)
|
40 |
+
|
41 |
+
![fixed](./examples/008502_fixed_6.png)
|
42 |
+
![moving](./examples/008502_moving_6.png)
|
43 |
+
![predicted](./examples/008502_pred_6.png)
|
44 |
+
|
45 |
+
The command shows an inference workflow with the checkpoint `"models/model_key_metric=-0.0890.pt"` and using device `"cuda:1"`:
|
46 |
+
```bash
|
47 |
+
python -m monai.bundle run eval \
|
48 |
+
--config_file configs/inference.yaml \
|
49 |
+
--ckpt "models/model_key_metric=-0.0890.pt" \
|
50 |
+
--logging_file configs/logging.conf \
|
51 |
+
--device "cuda:1"
|
52 |
+
```
|
53 |
+
|
54 |
+
## Fine-tuning for cross-subject alignments
|
55 |
+
|
56 |
+
The following commands starts a finetuning workflow based on the checkpoint `"models/model_key_metric=-0.0065.pt"`
|
57 |
+
for `5` epochs using the global mutual information loss.
|
58 |
+
|
59 |
+
```bash
|
60 |
+
python -m monai.bundle run training \
|
61 |
+
--config_file configs/train.yaml \
|
62 |
+
--cross_subjects True \
|
63 |
+
--ckpt "models/model_key_metric=-0.0065.pt" \
|
64 |
+
--lr 0.000001 \
|
65 |
+
--trainer#loss_function "@mutual_info_loss" \
|
66 |
+
--max_epochs 5
|
67 |
+
```
|
68 |
+
The following figure shows an inter-subject (`--cross_subjects True`) model inference results (Fixed, moving and predicted images from left to right)
|
69 |
+
|
70 |
+
![fixed](./examples/008501_fixed_7.png)
|
71 |
+
![moving](./examples/008504_moving_7.png)
|
72 |
+
![predicted](./examples/008504_pred_7.png)
|
73 |
+
|
74 |
+
## Visualize the first pair of images for debugging (requires `matplotlib`)
|
75 |
+
|
76 |
+
```bash
|
77 |
+
python -m monai.bundle run display --config_file configs/train.yaml
|
78 |
+
```
|
79 |
+
|
80 |
+
```bash
|
81 |
+
python -m monai.bundle run display --config_file configs/train.yaml --cross_subjects True
|
82 |
+
```
|
83 |
+
|
84 |
+
# License
|
85 |
+
Copyright (c) MONAI Consortium
|
86 |
+
|
87 |
+
Licensed under the Apache License, Version 2.0 (the "License");
|
88 |
+
you may not use this file except in compliance with the License.
|
89 |
+
You may obtain a copy of the License at
|
90 |
+
|
91 |
+
http://www.apache.org/licenses/LICENSE-2.0
|
92 |
+
|
93 |
+
Unless required by applicable law or agreed to in writing, software
|
94 |
+
distributed under the License is distributed on an "AS IS" BASIS,
|
95 |
+
WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
|
96 |
+
See the License for the specific language governing permissions and
|
97 |
+
limitations under the License.
|
docs/data_license.txt
ADDED
@@ -0,0 +1,24 @@
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
+
Copyright 2022 MONAI Consortium
|
2 |
+
Licensed under the Apache License, Version 2.0 (the "License");
|
3 |
+
you may not use this file except in compliance with the License.
|
4 |
+
You may obtain a copy of the License at
|
5 |
+
http://www.apache.org/licenses/LICENSE-2.0
|
6 |
+
Unless required by applicable law or agreed to in writing, software
|
7 |
+
distributed under the License is distributed on an "AS IS" BASIS,
|
8 |
+
WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
|
9 |
+
See the License for the specific language governing permissions and
|
10 |
+
limitations under the License.
|
11 |
+
|
12 |
+
Third Party Licenses
|
13 |
+
-----------------------------------------------------------------------
|
14 |
+
|
15 |
+
/*********************************************************************/
|
16 |
+
i. MedNIST Dataset
|
17 |
+
The dataset is kindly made available by Dr. Bradley J. Erickson M.D., Ph.D. (https://www.mayo.edu/research/labs/radiology-informatics/overview), Department of Radiology, Mayo Clinic under the Creative Commons [CC BY-SA 4.0 license](https://creativecommons.org/licenses/by-sa/4.0/).
|
18 |
+
|
19 |
+
The MedNIST dataset was gathered from several sets from:
|
20 |
+
* TCIA (https://wiki.cancerimagingarchive.net/display/Public/Data+Usage+Policies+and+Restrictions)
|
21 |
+
* the RSNA Bone Age Challenge (http://rsnachallenges.cloudapp.net/competitions/4),
|
22 |
+
* the NIH Chest X-ray dataset (https://cloud.google.com/healthcare/docs/resources/public-datasets/nih-chest).
|
23 |
+
|
24 |
+
If you use the MedNIST dataset, please acknowledge the source. For the license and usage conditions of the source datasets, please see their respective sites.
|
docs/examples/008501_fixed_7.png
ADDED
docs/examples/008502_fixed_6.png
ADDED
docs/examples/008502_moving_6.png
ADDED
docs/examples/008502_pred_6.png
ADDED
docs/examples/008504_moving_7.png
ADDED
docs/examples/008504_pred_7.png
ADDED
models/model.pt
ADDED
@@ -0,0 +1,3 @@
|
|
|
|
|
|
|
|
|
1 |
+
version https://git-lfs.github.com/spec/v1
|
2 |
+
oid sha256:1b997c0803bdfcde07394522809e09b1d7b41c38ccfc909f5d80ab5b7de8aed4
|
3 |
+
size 45611604
|
scripts/__init__.py
ADDED
@@ -0,0 +1,10 @@
|
|
|
|
|
|
|
|
|
|
|
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# Copyright (c) MONAI Consortium
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# Licensed under the Apache License, Version 2.0 (the "License");
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# you may not use this file except in compliance with the License.
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# You may obtain a copy of the License at
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# http://www.apache.org/licenses/LICENSE-2.0
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# Unless required by applicable law or agreed to in writing, software
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# distributed under the License is distributed on an "AS IS" BASIS,
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# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
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# See the License for the specific language governing permissions and
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# limitations under the License.
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scripts/net.py
ADDED
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# Copyright (c) MONAI Consortium
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# Licensed under the Apache License, Version 2.0 (the "License");
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# you may not use this file except in compliance with the License.
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# You may obtain a copy of the License at
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# http://www.apache.org/licenses/LICENSE-2.0
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# Unless required by applicable law or agreed to in writing, software
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# distributed under the License is distributed on an "AS IS" BASIS,
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# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
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# See the License for the specific language governing permissions and
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# limitations under the License.
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import torch.nn as nn
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from monai.networks.blocks import Warp
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from monai.networks.nets import resnet18
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from monai.networks.nets.regunet import AffineHead
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class RegResNet(nn.Module):
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def __init__(
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self,
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image_size=(64, 64),
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spatial_dims=2,
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mod=None,
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mode="bilinear",
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padding_mode="border",
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features=400, # feature dimension of `mod`
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):
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super().__init__()
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self.features = resnet18(n_input_channels=2, spatial_dims=spatial_dims) if mod is None else mod
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self.affine_head = AffineHead(
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spatial_dims=spatial_dims, image_size=image_size, decode_size=[1] * spatial_dims, in_channels=features
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)
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self.warp = Warp(mode=mode, padding_mode=padding_mode)
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self.image_size = image_size
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def forward(self, x):
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self.features.to(device=x.device)
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self.affine_head.to(device=x.device)
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out = self.features(x)
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ddf = self.affine_head([out], self.image_size)
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f = self.warp(x[:, :1], ddf) # warp the first channel
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return f
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