---
library_name: sentence-transformers
pipeline_tag: sentence-similarity
tags:
- sentence-transformers
- sentence-similarity
- feature-extraction
- generated_from_trainer
- dataset_size:26147930
- loss:MultipleNegativesRankingLoss
widget:
- source_sentence: >-
[YEAR_RANGE] 2020-2024 [TEXT] Vitamin B-6 Prevents Heart Failure with
Preserved Ejection Fraction Through Downstream of Kinase 3 in a Mouse Model.
sentences:
- >-
[YEAR_RANGE] 2020-2024 [TEXT] Colorectal cancer (CRC) is a complex and
genetically heterogeneous disease presenting a specific metastatic pattern,
with the liver being the most common site of metastasis. Around 20%-25% of
patients with CRC will develop exclusively hepatic metastatic disease
throughout their disease history. With its specific characteristics and
therapeutic options, liver-limited disease (LLD) should be considered as a
specific entity. The identification of these patients is particularly
relevant in view of the growing interest in liver transplantation in
selected patients with advanced CRC. Identifying why some patients will
develop only LLD remains a challenge, mainly because of a lack of a systemic
understanding of this complex and interlinked phenomenon given that cancer
has traditionally been investigated according to distinct physiological
compartments. Recently, multidisciplinary efforts and new diagnostic tools
have made it possible to study some of these complex issues in greater depth
and may help identify targets and specific treatment strategies to benefit
these patients. In this review we analyze the underlying biology and
available tools to help clinicians better understand this increasingly
common and specific disease.
- >-
[YEAR_RANGE] 2020-2024 [TEXT] PURPOSE: Secondary breast cancer is a frequent
late adverse event of mediastinal Hodgkin lymphoma radiotherapy. Secondary
breast cancers overwhelmingly correspond to ductal carcinoma and develop
from the glandular mammary tissue. In addition, during childhood, radiation
overexposure of the glandular tissue may lead to a late breast hypotrophy at
adult age. The aim of this study was to evaluate the radiation exposure to
the glandular tissue in patients treated for mediastinal Hodgkin lymphoma
with intensity-modulated proton therapy, in order to evaluate the potential
dosimetric usefulness of its delineation for breast sparing. MATERIALS AND
METHODS: Sixteen consecutive intermediate-risk mediastinal female patients
with Hodgkin lymphoma treated with consolidation radiation with deep
inspiration breath hold intensity-modulated proton therapy to the total dose
of 30Gy were included. Breasts were delineated according to the European
Society for Radiotherapy and Oncology guidelines for treatment optimization
("clinical organ at risk"). The glandular tissue ("glandular organ at risk")
was retrospectively contoured on the initial simulation CT scans based on
Hounsfield unit (HU) values, using a range between -80HU and 500HU. RESULTS:
The mean and maximum doses delivered to the glandular organ at risk were
significantly lower than the mean and maximum doses delivered to the
clinical organ at risk, but were statistically correlated. Glandular organ
at risk volumes were significantly smaller. CONCLUSION: Optimizing the
treatment plans on the clinical breast contours will systematically lead to
overestimation of the dose received to the glandular tissue and,
consequently, to an indistinct and involuntary improved glandular tissue
sparing. As such, our findings do not support the consideration of the
glandular tissue as an additional organ at risk when planning
intensity-modulated proton therapy for mediastinal Hodgkin lymphoma in
female patients.
- >-
[YEAR_RANGE] 2020-2024 [TEXT] BACKGROUND: There is an urgent need to develop
an efficient therapeutic strategy for heart failure with preserved ejection
fraction (HFpEF), which is mediated by phenotypic changes in cardiac
macrophages. We previously reported that vitamin B-6 inhibits
macrophage-mediated inflammasome activation. OBJECTIVES: We sought to
examine whether the prophylactic use of vitamin B-6 prevents HFpEF. METHODS:
HFpEF model was elicited by a combination of high-fat diet and
Nω-nitro-l-arginine methyl ester supplement in mice. Cardiac function was
assessed using conventional echocardiography and Doppler imaging.
Immunohistochemistry and immunoblotting were used to detect changes in the
macrophage phenotype and myocardial remodeling-related molecules. RESULTS:
Co-administration of vitamin B-6 with HFpEF mice mitigated HFpEF phenotypes,
including diastolic dysfunction, cardiac macrophage phenotypic shifts,
fibrosis, and hypertrophy. Echocardiographic improvements were observed,
with the E/E' ratio decreasing from 42.0 to 21.6 and the E/A ratio improving
from 2.13 to 1.17. The exercise capacity also increased from 295.3 to 657.7
min. However, these beneficial effects were negated in downstream of kinase
(DOK) 3-deficient mice. Mechanistically, vitamin B-6 increased DOK3 protein
concentrations and inhibited macrophage phenotypic changes, which were
abrogated by an AMP-activated protein kinase inhibitor. CONCLUSIONS: Vitamin
B-6 increases DOK3 signaling to lower risk of HFpEF by inhibiting phenotypic
changes in cardiac macrophages.
- source_sentence: >-
[YEAR_RANGE] 2020-2024 [TEXT] Resolving phylogenetic relationships and
taxonomic revision in the Pseudogastromyzon (Cypriniformes, Gastromyzonidae)
genus: molecular and morphological evidence for a new genus,
Labigastromyzon.
sentences:
- >-
[YEAR_RANGE] 2020-2024 [TEXT] Bats contain a diverse spectrum of viral
species in their bodies. The RNA virus family Paramyxoviridae tends to
infect several vertebrate species, which are accountable for a variety of
devastating infections in both humans and animals. Viruses of this kind
include measles, mumps, and Hendra. Some synonymous codons are favoured over
others in mRNAs during gene-to-protein synthesis process. Such phenomenon is
termed as codon usage bias (CUB). Our research emphasized many aspects that
shape the CUB of genes in the Paramyxoviridae family found in bats. Here,
the nitrogenous base A occurred the most. AT was found to be abundant in the
coding sequences of the Paramyxoviridae family. RSCU data revealed that A or
T ending codons occurred more frequently than predicted. Furthermore, 3
overrepresented codons (CAT, AGA, and GCA) and 7 underrepresented codons
(CCG, TCG, CGC, CGG, CGT, GCG and ACG) were detected in the viral genomes.
Correspondence analysis, neutrality plot, and parity plots highlight the
combined impact of mutational pressure and natural selection on CUB. The
neutrality plot of GC12 against GC3 yielded a regression coefficient value
of 0.366, indicating that natural selection had a significant (63.4 %)
impact. Moreover, RNA editing analysis was done, which revealed the highest
frequency of C to T mutations. The results of our research revealed the
pattern of codon usage and RNA editing sites in Paramyxoviridae genomes.
- >-
[YEAR_RANGE] 2020-2024 [TEXT] OBJECTIVE: The preoperative inclination angle
of mandibular incisors was crucial for surgical and postoperative stability
while the effect of proclined mandibular incisors on skeletal stability has
not been investigated. This study aimed to evaluate the effects of
differences in presurgical mandibular incisor inclination on skeletal
stability after orthognathic surgery in patients with skeletal Class III
malocclusion. METHODS: A retrospective cohort study of 80 consecutive
patients with skeletal Class III malocclusion who underwent bimaxillary
orthognathic surgery was conducted. According to incisor mandibular plane
angle (IMPA), patients were divided into 3 groups: retroclined inclination
(IMPA < 87°), normal inclination (87° ≤ IMPA < 93°) and proclined
inclination (IMPA ≥ 93°). Preoperative characteristics, surgical changes and
postoperative stability were compared based on lateral cephalograms obtained
1 week before surgery (T0), 1 week after surgery (T1), and at 6 to 12 months
postoperatively (T2). RESULTS: The mandible demonstrated a forward and
upward relapse in all three groups. No significant differences in skeletal
relapse were observed in the 3 groups of patients. However, the proclined
inclination group showed a negative overbite tendency postoperatively
compared with the other two groups and a clinically significant mandibular
relapse pattern. Proclined IMPA both pre- and postoperatively was correlated
with mandibular relapse. CONCLUSION: Sufficient presurgical mandibular
incisor decompensation was of crucial importance for the maintenance of
skeletal stability in patients with skeletal Class III malocclusion who
subsequently underwent orthognathic surgery.
- >-
[YEAR_RANGE] 2020-2024 [TEXT] The Pseudogastromyzon genus, consisting of
species predominantly distributed throughout southeastern China, has
garnered increasing market attention in recent years due to its ornamental
appeal. However, the overlapping diagnostic attributes render the commonly
accepted criteria for interspecific identification unreliable, leaving the
phylogenetic relationships among Pseudogastromyzon species unexplored. In
the present study, we undertake molecular phylogenetic and morphological
examinations of the Pseudogastromyzon genus. Our phylogenetic analysis of
mitochondrial genes distinctly segregated Pseudogastromyzon species into two
clades: the Pseudogastromyzon clade and the Labigastromyzon clade. A
subsequent morphological assessment revealed that the primary dermal ridge
(specifically, the second ridge) within the labial adhesive apparatus serves
as an effective and precise interspecific diagnostic characteristic.
Moreover, the distributional ranges of Pseudogastromyzon and Labigastromyzon
are markedly distinct, exhibiting only a narrow area of overlap. Considering
the morphological heterogeneity of the labial adhesive apparatus and the
substantial division within the molecular phylogeny, we advocate for the
elevation of the Labigastromyzon subgenus to the status of a separate genus.
Consequently, we have ascertained the validity of the Pseudogastromyzon and
Labigastromyzon species, yielding a total of six valid species. To
facilitate future research, we present comprehensive descriptions of the
redefined species and introduce novel identification keys.
- source_sentence: >-
[YEAR_RANGE] 2020-2024 [TEXT] PCa-RadHop: A transparent and lightweight
feed-forward method for clinically significant prostate cancer segmentation.
sentences:
- >-
[YEAR_RANGE] 2020-2024 [TEXT] According to the importance of time in
treatment of thrombosis disorders, faster than current treatments are
required. For the first time, this research discloses a novel strategy for
rapid dissolution of blood clots by encapsulation of a fibrinolytic
(Reteplase) into a Thrombin sensitive shell formed by polymerization of
acrylamide monomers and bisacryloylated peptide as crosslinker.
Degradability of the peptide units in exposure to Thrombin, creates the
Thrombin-sensitive Reteplase nanocapsules (TSRNPs) as a triggered release
system. Accelerated thrombolysis was achieved by combining three approaches
including: deep penetration of TSRNPs into the blood clots, changing the
clot dissolution mechanism by altering the distribution pattern of TSRNPs to
3D intra-clot distribution (based on the distributed intra-clot thrombolysis
(DIT) model) instead of peripheral and unidirectional distribution of
unencapsulated fibrinolytics and, enzyme-stimulated release of the
fibrinolytic. Ex-vivo study was carried out by an occluded tube model that
mimics in-vivo brain stroke as an emergency situation where faster treatment
in short time is a golden key. In in vivo, efficacy of the developed
formulation was confirmed by PET scan and laser Doppler flowmetry (LDF). As
the most important achievements, 40.0 ± 0.7 (n = 3) % and 37.0 ± 0.4 (n = 3)
% reduction in the thrombolysis time (faster reperfusion) were observed by
ex-vivo and in-vivo experiments, respectively. Higher blood flow and larger
digestion mass of clot at similar times in comparison to non-encapsulated
Reteplase were observed that means more effective thrombolysis by the
developed strategy.
- >-
[YEAR_RANGE] 2020-2024 [TEXT] Prostate Cancer is one of the most frequently
occurring cancers in men, with a low survival rate if not early diagnosed.
PI-RADS reading has a high false positive rate, thus increasing the
diagnostic incurred costs and patient discomfort. Deep learning (DL) models
achieve a high segmentation performance, although require a large model size
and complexity. Also, DL models lack of feature interpretability and are
perceived as "black-boxes" in the medical field. PCa-RadHop pipeline is
proposed in this work, aiming to provide a more transparent feature
extraction process using a linear model. It adopts the recently introduced
Green Learning (GL) paradigm, which offers a small model size and low
complexity. PCa-RadHop consists of two stages: Stage-1 extracts data-driven
radiomics features from the bi-parametric Magnetic Resonance Imaging
(bp-MRI) input and predicts an initial heatmap. To reduce the false positive
rate, a subsequent stage-2 is introduced to refine the predictions by
including more contextual information and radiomics features from each
already detected Region of Interest (ROI). Experiments on the largest
publicly available dataset, PI-CAI, show a competitive performance standing
of the proposed method among other deep DL models, achieving an area under
the curve (AUC) of 0.807 among a cohort of 1,000 patients. Moreover,
PCa-RadHop maintains orders of magnitude smaller model size and complexity.
- >-
[YEAR_RANGE] 2020-2024 [TEXT] OBJECTIVE: To evaluate rates of remission,
recovery, relapse, and recurrence in suicidal youth who participated in a
clinical trial comparing Dialectical Behavior Therapy (DBT) and Individual
and Group Supportive Therapy (IGST). METHOD: Participants were 173 youth,
aged 12 to 18 years, with repetitive self-harm (including at least 1 prior
suicide attempt [SA]) and elevated suicidal ideation (SI). Participants
received 6 months of DBT or IGST and were followed for 6 months
post-treatment. The sample was 95% female, 56.4% White, and 27.49% Latina.
Remission was defined as absence of SA or nonsuicidal self-injury (NSSI)
across one 3-month interval; recovery was defined across 2 or more
consecutive intervals. Relapse and recurrence were defined as SA or NSSI
following remission or recovery. Cross-tabulation with χ2 was used for
between-group contrasts. RESULTS: Over 70% of the sample reported remission
of SA at each treatment and follow-up interval. There were significantly
higher rates of remission and recovery and lower rates of relapse and
recurrence for SA in DBT than for IGST. Across treatments and time points,
SA had higher remission and recovery rates and lower relapse and recurrence
rates than NSSI. There were no significant differences in NSSI remission
between conditions; however, participants receiving DBT had significantly
higher NSSI recovery rates than those receiving IGST for the 3- to 9-month,
3- to 12-month, and 6- to 12-month intervals. CONCLUSION: Results showed
higher percentages of SA remission and recovery for DBT as compared to IGST.
NSSI was less likely to remit than SA. PLAIN LANGUAGE SUMMARY: This study
examined rates of remission, recovery, relapse, and recurrence of suicide
attempts (SA) and nonsuicidal self-injury (NSSI) among the participants in
the CARES Study, a randomized clinical trial of 6 months of Dialectical
Behavior Therapy or Individual and Group Supportive Therapy. 173 youth aged
12 to 18 years participated in the study and were followed for 6 months post
treatment. Over 70% of the sample reported remission of SA at each treatment
and follow-up interval. There were significantly higher rates of remission
and recovery and lower rates of relapse and recurrence for SA among
participants who received Dialectical Behavioral Therapy. Across both
treatments, remission and recovery rates were lower and relapse and
recurrence rates were higher for NSSI than for SA. These results underscore
the value of Dialectical Behavioral Therapy as a first line treatment for
youth at high risk for suicide. DIVERSITY & INCLUSION STATEMENT: We worked
to ensure race, ethnic, and/or other types of diversity in the recruitment
of human participants. CLINICAL TRIAL REGISTRATION INFORMATION:
Collaborative Adolescent Research on Emotions and Suicide (CARES);
https://www. CLINICALTRIALS: gov/; NCT01528020.
- source_sentence: >-
[YEAR_RANGE] 2020-2024 [TEXT] Predicting Recovery After Concussion in
Pediatric Patients: A Meta-Analysis.
sentences:
- >-
[YEAR_RANGE] 2020-2024 [TEXT] OBJECTIVE: The authors examined licensing
requirements for select children's behavioral health care providers.
METHODS: Statutes and regulations as of October 2021 were reviewed for
licensed clinical social workers, licensed professional counselors, and
licensed marriage and family therapists for all 50 U.S. states and the
District of Columbia. RESULTS: All jurisdictions had laws regarding
postgraduate training and license portability. No jurisdiction included
language about specialized postgraduate training related to serving children
and families or cultural competence. Other policies that related to the
structure, composition, and authority of licensing boards varied across
states and licensure types. CONCLUSIONS: In their efforts to address
barriers to licensure, expand the workforce, and ensure that children have
access to high-quality and culturally responsive care, states could consider
their statutes and regulations.
- >-
[YEAR_RANGE] 2020-2024 [TEXT] Magnetic Resonance Imaging (MRI) plays a
pivotal role in the accurate measurement of brain subcortical structures in
macaques, which is crucial for unraveling the complexities of brain
structure and function, thereby enhancing our understanding of
neurodegenerative diseases and brain development. However, due to
significant differences in brain size, structure, and imaging
characteristics between humans and macaques, computational tools developed
for human neuroimaging studies often encounter obstacles when applied to
macaques. In this context, we propose an Anatomy Attentional Fusion Network
(AAF-Net), which integrates multimodal MRI data with anatomical constraints
in a multi-scale framework to address the challenges posed by the dynamic
development, regional heterogeneity, and age-related size variations of the
juvenile macaque brain, thus achieving precise subcortical segmentation.
Specifically, we generate a Signed Distance Map (SDM) based on the initial
rough segmentation of the subcortical region by a network as an anatomical
constraint, providing comprehensive information on positions, structures,
and morphology. Then we construct AAF-Net to fully fuse the SDM anatomical
constraints and multimodal images for refined segmentation. To thoroughly
evaluate the performance of our proposed tool, over 700 macaque MRIs from 19
datasets were used in this study. Specifically, we employed two manually
labeled longitudinal macaque datasets to develop the tool and complete
four-fold cross-validations. Furthermore, we incorporated various external
datasets to demonstrate the proposed tool's generalization capabilities and
promise in brain development research. We have made this tool available as
an open-source resource at
https://github.com/TaoZhong11/Macaque_subcortical_segmentation for direct
application.
- >-
[YEAR_RANGE] 2020-2024 [TEXT] CONTEXT: Prognostic prediction models (PPMs)
can help clinicians predict outcomes. OBJECTIVE: To critically examine
peer-reviewed PPMs predicting delayed recovery among pediatric patients with
concussion. DATA SOURCES: Ovid Medline, Embase, Ovid PsycInfo, Web of
Science Core Collection, Cumulative Index to Nursing and Allied Health
Literature, Cochrane Library, Google Scholar. STUDY SELECTION: The study had
to report a PPM for pediatric patients to be used within 28 days of injury
to estimate risk of delayed recovery at 28 days to 1 year postinjury.
Studies had to have at least 30 participants. DATA EXTRACTION: The Critical
Appraisal and Data Extraction for Systematic Reviews of Prediction Modeling
Studies checklist was completed. RESULTS: Six studies of 13 PPMs were
included. These studies primarily reflected male patients in late childhood
or early adolescence presenting to an emergency department meeting the
Concussion in Sport Group concussion criteria. No study authors used the
same outcome definition nor evaluated the clinical utility of a model. All
studies demonstrated high risk of bias. Quality of evidence was best for the
Predicting and Preventing Postconcussive Problems in Pediatrics (5P)
clinical risk score. LIMITATIONS: No formal PPM Grading of Recommendations,
Assessment, Development, and Evaluations (GRADE) process exists.
CONCLUSIONS: The 5P clinical risk score may be considered for clinical use.
Rigorous external validations, particularly in other settings, are needed.
The remaining PPMs require external validation. Lack of consensus regarding
delayed recovery criteria limits these PPMs.
- source_sentence: >-
[YEAR_RANGE] 2020-2024 [TEXT] Intraoperative Monitoring of the External
Urethral Sphincter Reflex: A Novel Adjunct to Bulbocavernosus Reflex
Neuromonitoring for Protecting the Sacral Neural Pathways Responsible for
Urination, Defecation and Sexual Function.
sentences:
- >-
[YEAR_RANGE] 2020-2024 [TEXT] Early menarche has been associated with
adverse health outcomes, such as depressive symptoms. Discovering effect
modifiers across these conditions in the pediatric population is a constant
challenge. We tested whether movement behaviours modified the effect of the
association between early menarche and depression symptoms among
adolescents. This cross-sectional study included 2031 females aged 15-19
years across all Brazilian geographic regions. Data were collected using a
self-administered questionnaire; 30.5% (n = 620) reported having experienced
menarche before age 12 years (that is, early menarche). We used the Patient
Health Questionnaire (PHQ-9) to evaluate depressive symptoms. Accruing any
moderate-vigorous physical activity during leisure time, limited
recreational screen time, and having good sleep quality were the exposures
investigated. Adolescents who experienced early menarche and met one (B:
-4.45, 95% CI: (-5.38, -3.51)), two (B: -6.07 (-7.02, -5.12)), or three (B:
-6.49 (-7.76, -5.21)), and adolescents who experienced not early menarche
and met one (B: -5.33 (-6.20; -4.46)), two (B: -6.12 (-6.99; -5.24)), or
three (B: -6.27 (-7.30; -5.24)) of the movement behaviour targets had lower
PHQ-9 scores for depression symptoms than adolescents who experienced early
menarche and did not meet any of the movement behaviours. The disparities in
depressive symptoms among the adolescents (early menarche versus not early
menarche) who adhered to all three target behaviours were not statistically
significant (B: 0.41 (-0.19; 1.01)). Adherence to movement behaviours
modified the effect of the association between early menarche and depression
symptoms.
- >-
[YEAR_RANGE] 2020-2024 [TEXT] PURPOSE: Intraoperative bulbocavernosus reflex
neuromonitoring has been utilized to protect bowel, bladder, and sexual
function, providing a continuous functional assessment of the somatic sacral
nervous system during surgeries where it is at risk. Bulbocavernosus reflex
data may also provide additional functional insight, including an evaluation
for spinal shock, distinguishing upper versus lower motor neuron injury
(conus versus cauda syndromes) and prognosis for postoperative bowel and
bladder function. Continuous intraoperative bulbocavernosus reflex
monitoring has been utilized to provide the surgeon with an ongoing
functional assessment of the anatomical elements involved in the S2-S4
mediated reflex arc including the conus, cauda equina and pudendal nerves.
Intraoperative bulbocavernosus reflex monitoring typically includes the
electrical activation of the dorsal nerves of the genitals to initiate the
afferent component of the reflex, followed by recording the resulting muscle
response using needle electromyography recordings from the external anal
sphincter. METHODS: Herein we describe a complementary and novel technique
that includes recording electromyography responses from the external
urethral sphincter to monitor the external urethral sphincter reflex.
Specialized foley catheters embedded with recording electrodes have recently
become commercially available that provide the ability to perform
intraoperative external urethral sphincter muscle recordings. RESULTS: We
describe technical details and the potential utility of incorporating
external urethral sphincter reflex recordings into existing sacral
neuromonitoring paradigms to provide redundant yet complementary data
streams. CONCLUSIONS: We present two illustrative neurosurgical oncology
cases to demonstrate the utility of the external urethral sphincter reflex
technique in the setting of the necessary surgical sacrifice of sacral nerve
roots.
- >-
[YEAR_RANGE] 2020-2024 [TEXT] BACKGROUND: Limited data are available on the
appropriate choice of blood pressure management strategy for patients with
acute basilar artery occlusion assessed by the standard deviation (SD).
Multivariate logistic models were used to investigate the association
between BPV, the primary outcome (futile recanalization, 90-day modified
Rankin Scale score 3-6), and the secondary outcome (30-day mortality).
Subgroup analysis was performed as a sensitivity test. RESULTS: Futile
recanalization occurred in 60 (56 %) patients, while 26 (24 %) patients died
within 30 days. In the fully adjusted model, MAP SD was associated with a
higher risk of futile recanalization (OR adj=1.36, per 1 mmHg increase, 95 %
CI: 1.09-1.69, P=0.006) and 30-day mortality (OR adj=1.56, per 1 mmHg
increase, 95 % CI: 1.20-2.04, P=0.001). A significant interaction between
MAP SD and the lack of hypertension history on futile recanalization
(P<0.05) was observed. CONCLUSIONS: Among recanalized acute BAO ischemic
patients, higher blood pressure variability during the first 24 h after MT
was associated with worse outcomes. This association was stronger in
patients without a history of hypertension.
base_model:
- pankajrajdeo/UMLS-ED-Bioformer-16L-V-1.25-SpecialTokensUntrained
---
# SentenceTransformer
This is a [sentence-transformers](https://www.SBERT.net) model trained on the parquet dataset. It maps sentences & paragraphs to a 384-dimensional dense vector space and can be used for semantic textual similarity, semantic search, paraphrase mining, text classification, clustering, and more.
## Model Details
### Model Description
- **Model Type:** Sentence Transformer
- **Maximum Sequence Length:** 1024 tokens
- **Output Dimensionality:** 384 tokens
- **Similarity Function:** Cosine Similarity
- **Training Dataset:**
- parquet
### Model Sources
- **Documentation:** [Sentence Transformers Documentation](https://sbert.net)
- **Repository:** [Sentence Transformers on GitHub](https://github.com/UKPLab/sentence-transformers)
- **Hugging Face:** [Sentence Transformers on Hugging Face](https://huggingface.co/models?library=sentence-transformers)
### Full Model Architecture
```
SentenceTransformer(
(0): Transformer({'max_seq_length': 1024, 'do_lower_case': False}) with Transformer model: BertModel
(1): Pooling({'word_embedding_dimension': 384, 'pooling_mode_cls_token': False, 'pooling_mode_mean_tokens': True, 'pooling_mode_max_tokens': False, 'pooling_mode_mean_sqrt_len_tokens': False, 'pooling_mode_weightedmean_tokens': False, 'pooling_mode_lasttoken': False, 'include_prompt': True})
)
```
## Usage
### Direct Usage (Sentence Transformers)
First install the Sentence Transformers library:
```bash
pip install -U sentence-transformers
```
Then you can load this model and run inference.
```python
from sentence_transformers import SentenceTransformer
# Download from the 🤗 Hub
model = SentenceTransformer("pankajrajdeo/UMLS-Pubmed-ST-TCE-Epoch-2")
# Run inference
sentences = [
'[YEAR_RANGE] 2020-2024 [TEXT] Intraoperative Monitoring of the External Urethral Sphincter Reflex: A Novel Adjunct to Bulbocavernosus Reflex Neuromonitoring for Protecting the Sacral Neural Pathways Responsible for Urination, Defecation and Sexual Function.',
'[YEAR_RANGE] 2020-2024 [TEXT] PURPOSE: Intraoperative bulbocavernosus reflex neuromonitoring has been utilized to protect bowel, bladder, and sexual function, providing a continuous functional assessment of the somatic sacral nervous system during surgeries where it is at risk. Bulbocavernosus reflex data may also provide additional functional insight, including an evaluation for spinal shock, distinguishing upper versus lower motor neuron injury (conus versus cauda syndromes) and prognosis for postoperative bowel and bladder function. Continuous intraoperative bulbocavernosus reflex monitoring has been utilized to provide the surgeon with an ongoing functional assessment of the anatomical elements involved in the S2-S4 mediated reflex arc including the conus, cauda equina and pudendal nerves. Intraoperative bulbocavernosus reflex monitoring typically includes the electrical activation of the dorsal nerves of the genitals to initiate the afferent component of the reflex, followed by recording the resulting muscle response using needle electromyography recordings from the external anal sphincter. METHODS: Herein we describe a complementary and novel technique that includes recording electromyography responses from the external urethral sphincter to monitor the external urethral sphincter reflex. Specialized foley catheters embedded with recording electrodes have recently become commercially available that provide the ability to perform intraoperative external urethral sphincter muscle recordings. RESULTS: We describe technical details and the potential utility of incorporating external urethral sphincter reflex recordings into existing sacral neuromonitoring paradigms to provide redundant yet complementary data streams. CONCLUSIONS: We present two illustrative neurosurgical oncology cases to demonstrate the utility of the external urethral sphincter reflex technique in the setting of the necessary surgical sacrifice of sacral nerve roots.',
'[YEAR_RANGE] 2020-2024 [TEXT] Early menarche has been associated with adverse health outcomes, such as depressive symptoms. Discovering effect modifiers across these conditions in the pediatric population is a constant challenge. We tested whether movement behaviours modified the effect of the association between early menarche and depression symptoms among adolescents. This cross-sectional study included 2031 females aged 15-19 years across all Brazilian geographic regions. Data were collected using a self-administered questionnaire; 30.5% (n = 620) reported having experienced menarche before age 12 years (that is, early menarche). We used the Patient Health Questionnaire (PHQ-9) to evaluate depressive symptoms. Accruing any moderate-vigorous physical activity during leisure time, limited recreational screen time, and having good sleep quality were the exposures investigated. Adolescents who experienced early menarche and met one (B: -4.45, 95% CI: (-5.38, -3.51)), two (B: -6.07 (-7.02, -5.12)), or three (B: -6.49 (-7.76, -5.21)), and adolescents who experienced not early menarche and met one (B: -5.33 (-6.20; -4.46)), two (B: -6.12 (-6.99; -5.24)), or three (B: -6.27 (-7.30; -5.24)) of the movement behaviour targets had lower PHQ-9 scores for depression symptoms than adolescents who experienced early menarche and did not meet any of the movement behaviours. The disparities in depressive symptoms among the adolescents (early menarche versus not early menarche) who adhered to all three target behaviours were not statistically significant (B: 0.41 (-0.19; 1.01)). Adherence to movement behaviours modified the effect of the association between early menarche and depression symptoms.',
]
embeddings = model.encode(sentences)
print(embeddings.shape)
# [3, 384]
# Get the similarity scores for the embeddings
similarities = model.similarity(embeddings, embeddings)
print(similarities.shape)
# [3, 3]
```
## Training Details
### Training Dataset
#### parquet
* Dataset: parquet
* Size: 26,147,930 training samples
* Columns: anchor
and positive
* Approximate statistics based on the first 1000 samples:
| | anchor | positive |
|:--------|:------------------------------------------------------------------------------------|:--------------------------------------------------------------------------------------|
| type | string | string |
| details |
[YEAR_RANGE] 1880-1884 [TEXT] ADDRESS OF COL. GARRICK MALLERY, U. S. ARMY.
| [YEAR_RANGE] 1880-1884 [TEXT] It may be conceded that after man had all his present faculties, he did not choose between the adoption of voice and gesture, and never with those faculties, was in a state where the one was used, to the absolute exclusion of the other. The epoch, however, to which our speculations relate is that in which he had not reached the present symmetric development of his intellect and of his bodily organs, and the inquiry is: Which mode of communication was earliest adopted to his single wants and informed intelligence? With the voice he could imitate distinictively but few sounds of nature, while with gesture he could exhibit actions, motions, positions, forms, dimensions, directions and distances, with their derivations and analogues. It would seem from this unequal division of capacity that oral speech remained rudimentary long after gesture had become an efficient mode of communication. With due allowance for all purely imitative sounds, and for the spontaneous action of vocal organs under excitement, it appears that the connection between ideas and words is only to be explained by a compact between speaker and hearer which supposes the existence of a prior mode of communication. This was probably by gesture. At least we may accept it as a clew leading out of the labyrinth of philological confusion, and regulating the immemorial quest of man's primitive speech.
|
| [YEAR_RANGE] 1880-1884 [TEXT] How TO OBTAIN THE BRAIN OF THE CAT.
| [YEAR_RANGE] 1880-1884 [TEXT] How to obtain the Brain of the Cat, (Wilder).-Correction: Page 158, second column, line 7, "grains," should be "grams;" page 159, near middle of 2nd column, "successily," should be "successively;" page 161, the number of Flower's paper is 3.
|
| [YEAR_RANGE] 1880-1884 [TEXT] DOLBEAR ON THE NATURE AND CONSTITUTION OF MATTER.
| [YEAR_RANGE] 1880-1884 [TEXT] Mr. Dopp desires to make the following correction in his paper in the last issue: "In my article on page 200 of "Science", the expression and should have been and being the velocity of light.
|
* Loss: [MultipleNegativesRankingLoss
](https://sbert.net/docs/package_reference/sentence_transformer/losses.html#multiplenegativesrankingloss) with these parameters:
```json
{
"scale": 20.0,
"similarity_fct": "cos_sim"
}
```
### Evaluation Dataset
#### parquet
* Dataset: parquet
* Size: 26,147,930 evaluation samples
* Columns: anchor
and positive
* Approximate statistics based on the first 1000 samples:
| | anchor | positive |
|:--------|:-----------------------------------------------------------------------------------|:-------------------------------------------------------------------------------------|
| type | string | string |
| details | [YEAR_RANGE] 2020-2024 [TEXT] Solubility and thermodynamics of mesalazine in aqueous mixtures of poly ethylene glycol 200/600 at 293.2-313.2K.
| [YEAR_RANGE] 2020-2024 [TEXT] In this study, the solubility of mesalazine was investigated in binary solvent mixtures of poly ethylene glycols 200/600 and water at temperatures ranging from 293.2K to 313.2K. The solubility of mesalazine was determined using a shake-flask method, and its concentrations were measured using a UV-Vis spectrophotometer. The obtained solubility data were analyzed using mathematical models including the van't Hoff, Jouyban-Acree, Jouyban-Acree-van't Hoff, mixture response surface, and modified Wilson models. The experimental data obtained for mesalazine dissolution encompassed various thermodynamic properties, including ΔG°, ΔH°, ΔS°, and TΔS°. These properties offer valuable insights into the energetic aspects of the dissolution process and were calculated based on the van't Hoff equation.
|
| [YEAR_RANGE] 2020-2024 [TEXT] Safety and efficacy of remimazolam versus propofol during EUS: a multicenter randomized controlled study.
| [YEAR_RANGE] 2020-2024 [TEXT] BACKGROUND AND AIMS: Propofol, a widely used sedative in GI endoscopic procedures, is associated with cardiorespiratory suppression. Remimazolam is a novel ultrashort-acting benzodiazepine sedative with rapid onset and minimal cardiorespiratory depression. This study compared the safety and efficacy of remimazolam and propofol during EUS procedures. METHODS: A multicenter randomized controlled study was conducted between October 2022 and March 2023 in patients who underwent EUS procedures. Patients were randomly assigned to receive either remimazolam or propofol as a sedative agent. The primary endpoint was cardiorespiratory adverse events.
|
| [YEAR_RANGE] 2020-2024 [TEXT] Ultrasound-Guided Vs Non-Guided Prolotherapy for Internal Derangement of Temporomandibular Joint. A Randomized Clinical Trial.
| [YEAR_RANGE] 2020-2024 [TEXT] OBJECTIVES: This randomized clinical trial study aims to compare ultrasound-guided versus non-guided Dextrose 10% injections in patients suffering from internal derangement in the temporomandibular joint (TMJ). MATERIAL AND METHODS: The study population included 22 patients and 43 TMJs suffering from unilateral or bilateral TMJ painful clicking, magnetic resonance imaging (MRI) proved disc displacement with reduction (DDWR), refractory to or failed conservative treatment. The patients were divided randomly into two groups (non-guided and ultrasound (US)-guided groups). The procedure involved injection of 2 mL solution of a mixture of 0.75 mL 0.9% normal saline solution, 0.3 mL 2% lidocaine and 0.75 mL dextrose 10% using a 25G needle in the joint and 1 mL intramuscular injection to the masseter muscle at the most tender point. The Visual Analogue Score (VAS) was used to compare joint pain intensity over four different periods, beginning with pre-injection, 1-, 2-, and 6-months postinjection. RESULTS: Twenty-two patients 5 males (n = 5/22, 22.7%) and 17 females (n = 17/22, 77.2%) were included in this study. The mean age was 27.3 ± 7.4 years (30.2 ± 7.0) for the non-guided group and 24.3 ± 6.9 for the US-guided group. The dextrose injection reduced intensity over time in both groups with statistically significant improvement (P value <.05) at 2 and 6 months in both groups. There was no statistically significant difference in VAS assessment between both groups. CONCLUSION: Intra-articular injection of dextrose 10% for patients with painful clicking and DDWR resulted in reduced pain intensity in both US-guided and non-guided groups with significant symptomatic improvement over time in both groups. US guidance allowed accurate anatomical localization and safe procedure with a single joint puncture.
|
* Loss: [MultipleNegativesRankingLoss
](https://sbert.net/docs/package_reference/sentence_transformer/losses.html#multiplenegativesrankingloss) with these parameters:
```json
{
"scale": 20.0,
"similarity_fct": "cos_sim"
}
```
### Training Hyperparameters
#### Non-Default Hyperparameters
- `eval_strategy`: steps
- `per_device_train_batch_size`: 128
- `learning_rate`: 2e-05
- `num_train_epochs`: 5
- `max_steps`: 970330
- `log_level`: info
- `fp16`: True
- `dataloader_num_workers`: 16
- `load_best_model_at_end`: True
- `resume_from_checkpoint`: True
#### All Hyperparameters