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Feb 2

Model-free Approach to Evaluate a Censored Intermediate Outcome as a Surrogate for Overall Survival

Clinical trials or studies oftentimes require long-term and/or costly follow-up of participants to evaluate a novel treatment/drug/vaccine. There has been increasing interest in the past few decades in using short-term surrogate outcomes as a replacement of the primary outcome i.e., in using the surrogate outcome, which can potentially be observed sooner, to make inference about the treatment effect on the long-term primary outcome. Very few of the available statistical methods to evaluate a surrogate are applicable to settings where both the surrogate and the primary outcome are time-to-event outcomes subject to censoring. Methods that can handle this setting tend to require parametric assumptions or be limited to assessing only the restricted mean survival time. In this paper, we propose a non-parametric approach to evaluate a censored surrogate outcome, such as time to progression, when the primary outcome is also a censored time-to-event outcome, such as time to death, and the treatment effect of interest is the difference in overall survival. Specifically, we define the proportion of the treatment effect on the primary outcome that is explained (PTE) by the censored surrogate outcome in this context, and estimate this proportion by defining and deriving an optimal transformation of the surrogate information. Our approach provides the added advantage of relaxed assumptions to guarantee that the true PTE is within (0,1), along with being model-free. Finite sample performance of our estimators are illustrated via extensive simulation studies and a real data application examining progression-free survival as a surrogate for overall survival for patients with metastatic colorectal cancer.

  • 4 authors
·
Dec 18, 2024

Facilitating Pornographic Text Detection for Open-Domain Dialogue Systems via Knowledge Distillation of Large Language Models

Pornographic content occurring in human-machine interaction dialogues can cause severe side effects for users in open-domain dialogue systems. However, research on detecting pornographic language within human-machine interaction dialogues is an important subject that is rarely studied. To advance in this direction, we introduce CensorChat, a dialogue monitoring dataset aimed at detecting whether the dialogue session contains pornographic content. To this end, we collect real-life human-machine interaction dialogues in the wild and break them down into single utterances and single-turn dialogues, with the last utterance spoken by the chatbot. We propose utilizing knowledge distillation of large language models to annotate the dataset. Specifically, first, the raw dataset is annotated by four open-source large language models, with the majority vote determining the label. Second, we use ChatGPT to update the empty label from the first step. Third, to ensure the quality of the validation and test sets, we utilize GPT-4 for label calibration. If the current label does not match the one generated by GPT-4, we employ a self-criticism strategy to verify its correctness. Finally, to facilitate the detection of pornographic text, we develop a series of text classifiers using a pseudo-labeled dataset. Detailed data analysis demonstrates that leveraging knowledge distillation techniques with large language models provides a practical and cost-efficient method for developing pornographic text detectors.

  • 5 authors
·
Mar 19, 2024

Empirical Risk Minimization under Random Censorship: Theory and Practice

We consider the classic supervised learning problem, where a continuous non-negative random label Y (i.e. a random duration) is to be predicted based upon observing a random vector X valued in R^d with dgeq 1 by means of a regression rule with minimum least square error. In various applications, ranging from industrial quality control to public health through credit risk analysis for instance, training observations can be right censored, meaning that, rather than on independent copies of (X,Y), statistical learning relies on a collection of ngeq 1 independent realizations of the triplet (X, ; min{Y,; C},; δ), where C is a nonnegative r.v. with unknown distribution, modeling censorship and δ=I{Yleq C} indicates whether the duration is right censored or not. As ignoring censorship in the risk computation may clearly lead to a severe underestimation of the target duration and jeopardize prediction, we propose to consider a plug-in estimate of the true risk based on a Kaplan-Meier estimator of the conditional survival function of the censorship C given X, referred to as Kaplan-Meier risk, in order to perform empirical risk minimization. It is established, under mild conditions, that the learning rate of minimizers of this biased/weighted empirical risk functional is of order O_{P}(log(n)/n) when ignoring model bias issues inherent to plug-in estimation, as can be attained in absence of censorship. Beyond theoretical results, numerical experiments are presented in order to illustrate the relevance of the approach developed.

  • 3 authors
·
Jun 5, 2019

Advancing Content Moderation: Evaluating Large Language Models for Detecting Sensitive Content Across Text, Images, and Videos

The widespread dissemination of hate speech, harassment, harmful and sexual content, and violence across websites and media platforms presents substantial challenges and provokes widespread concern among different sectors of society. Governments, educators, and parents are often at odds with media platforms about how to regulate, control, and limit the spread of such content. Technologies for detecting and censoring the media contents are a key solution to addressing these challenges. Techniques from natural language processing and computer vision have been used widely to automatically identify and filter out sensitive content such as offensive languages, violence, nudity, and addiction in both text, images, and videos, enabling platforms to enforce content policies at scale. However, existing methods still have limitations in achieving high detection accuracy with fewer false positives and false negatives. Therefore, more sophisticated algorithms for understanding the context of both text and image may open rooms for improvement in content censorship to build a more efficient censorship system. In this paper, we evaluate existing LLM-based content moderation solutions such as OpenAI moderation model and Llama-Guard3 and study their capabilities to detect sensitive contents. Additionally, we explore recent LLMs such as GPT, Gemini, and Llama in identifying inappropriate contents across media outlets. Various textual and visual datasets like X tweets, Amazon reviews, news articles, human photos, cartoons, sketches, and violence videos have been utilized for evaluation and comparison. The results demonstrate that LLMs outperform traditional techniques by achieving higher accuracy and lower false positive and false negative rates. This highlights the potential to integrate LLMs into websites, social media platforms, and video-sharing services for regulatory and content moderation purposes.

  • 4 authors
·
Nov 26, 2024