Daily Papers

We demonstrate how AI agents can coordinate to deceive oversight systems using automated interpretability of neural networks. Using sparse autoencoders (SAEs) as our experimental framework, we show that language models (Llama, DeepSeek R1, and Claude 3.7 Sonnet) can generate deceptive explanations that evade detection. Our agents employ steganographic methods to hide information in seemingly innocent explanations, successfully fooling oversight models while achieving explanation quality comparable to reference labels. We further find that models can scheme to develop deceptive strategies when they believe the detection of harmful features might lead to negative consequences for themselves. All tested LLM agents were capable of deceiving the overseer while achieving high interpretability scores comparable to those of reference labels. We conclude by proposing mitigation strategies, emphasizing the critical need for robust understanding and defenses against deception.

As Language Model (LM) capabilities advance, evaluating and supervising them at scale is getting harder for humans. There is hope that other language models can automate both these tasks, which we refer to as "AI Oversight". We study how model similarity affects both aspects of AI oversight by proposing a probabilistic metric for LM similarity based on overlap in model mistakes. Using this metric, we first show that LLM-as-a-judge scores favor models similar to the judge, generalizing recent self-preference results. Then, we study training on LM annotations, and find complementary knowledge between the weak supervisor and strong student model plays a crucial role in gains from "weak-to-strong generalization". As model capabilities increase, it becomes harder to find their mistakes, and we might defer more to AI oversight. However, we observe a concerning trend -- model mistakes are becoming more similar with increasing capabilities, pointing to risks from correlated failures. Our work underscores the importance of reporting and correcting for model similarity, especially in the emerging paradigm of AI oversight.

We test the robustness of debate as a method of scalable oversight by training models to debate with data generated via self-play. In a long-context reading comprehension task, we find that language model based evaluators answer questions more accurately when judging models optimized to win debates. By contrast, we find no such relationship for consultancy models trained to persuade a judge without an opposing debater present. In quantitative and qualitative comparisons between our debate models and novel consultancy baselines, we find evidence that debate training encourages stronger and more informative arguments, showing promise that it can help provide high-quality supervision for tasks that are difficult to directly evaluate.

With the rapid development of artificial intelligence, large language models (LLMs) have shown promising capabilities in mimicking human-level language comprehension and reasoning. This has sparked significant interest in applying LLMs to enhance various aspects of healthcare, ranging from medical education to clinical decision support. However, medicine involves multifaceted data modalities and nuanced reasoning skills, presenting challenges for integrating LLMs. This paper provides a comprehensive review on the applications and implications of LLMs in medicine. It begins by examining the fundamental applications of general-purpose and specialized LLMs, demonstrating their utilities in knowledge retrieval, research support, clinical workflow automation, and diagnostic assistance. Recognizing the inherent multimodality of medicine, the review then focuses on multimodal LLMs, investigating their ability to process diverse data types like medical imaging and EHRs to augment diagnostic accuracy. To address LLMs' limitations regarding personalization and complex clinical reasoning, the paper explores the emerging development of LLM-powered autonomous agents for healthcare. Furthermore, it summarizes the evaluation methodologies for assessing LLMs' reliability and safety in medical contexts. Overall, this review offers an extensive analysis on the transformative potential of LLMs in modern medicine. It also highlights the pivotal need for continuous optimizations and ethical oversight before these models can be effectively integrated into clinical practice. Visit https://github.com/mingze-yuan/Awesome-LLM-Healthcare for an accompanying GitHub repository containing latest papers.

As language models regularly make mistakes when solving math problems, automated identification of errors in the reasoning process becomes increasingly significant for their scalable oversight. In this paper, we introduce ProcessBench for measuring the ability to identify erroneous steps in mathematical reasoning. It consists of 3,400 test cases, primarily focused on competition- and Olympiad-level math problems. Each test case contains a step-by-step solution with error location annotated by human experts. Models are required to identify the earliest step that contains an error, or conclude that all steps are correct. We conduct extensive evaluation on ProcessBench, involving two types of models: process reward models (PRMs) and critic models, where for the latter we prompt general language models to critique each solution step by step. We draw two main observations: (1) Existing PRMs typically fail to generalize to more challenging math problems beyond GSM8K and MATH. They underperform both critic models (i.e., prompted general language models) and our own trained PRM that is straightforwardly fine-tuned on the PRM800K dataset. (2) The best open-source model, QwQ-32B-Preview, has demonstrated the critique capability competitive with the proprietary model GPT-4o, despite that it still lags behind the reasoning-specialized o1-mini. We hope ProcessBench can foster future research in reasoning process assessment, paving the way toward scalable oversight of language models.

Scalable oversight protocols aim to enable humans to accurately supervise superhuman AI. In this paper we study debate, where two AI's compete to convince a judge; consultancy, where a single AI tries to convince a judge that asks questions; and compare to a baseline of direct question-answering, where the judge just answers outright without the AI. We use large language models (LLMs) as both AI agents and as stand-ins for human judges, taking the judge models to be weaker than agent models. We benchmark on a diverse range of asymmetries between judges and agents, extending previous work on a single extractive QA task with information asymmetry, to also include mathematics, coding, logic and multimodal reasoning asymmetries. We find that debate outperforms consultancy across all tasks when the consultant is randomly assigned to argue for the correct/incorrect answer. Comparing debate to direct question answering, the results depend on the type of task: in extractive QA tasks with information asymmetry debate outperforms direct question answering, but in other tasks without information asymmetry the results are mixed. Previous work assigned debaters/consultants an answer to argue for. When we allow them to instead choose which answer to argue for, we find judges are less frequently convinced by the wrong answer in debate than in consultancy. Further, we find that stronger debater models increase judge accuracy, though more modestly than in previous studies.

The process of instruction tuning aligns pre-trained large language models (LLMs) with open-domain instructions and human-preferred responses. While several studies have explored autonomous approaches to distilling and annotating instructions from more powerful proprietary LLMs, such as ChatGPT, they often neglect the impact of task distributions and the varying difficulty of instructions of the training sets. This oversight can lead to imbalanced knowledge capabilities and poor generalization powers of small student LLMs. To address this challenge, we introduce Task-Aware Curriculum Planning for Instruction Refinement (TAPIR), a multi-round distillation framework with balanced task distributions and dynamic difficulty adjustment. This approach utilizes an oracle LLM to select instructions that are difficult for a student LLM to follow and distill instructions with balanced task distributions. By incorporating curriculum planning, our approach systematically escalates the difficulty levels, progressively enhancing the student LLM's capabilities. We rigorously evaluate TAPIR using two widely recognized benchmarks, including AlpacaEval 2.0 and MT-Bench. The empirical results demonstrate that the student LLMs, trained with our method and less training data, outperform larger instruction-tuned models and strong distillation baselines. The improvement is particularly notable in complex tasks, such as logical reasoning and code generation.

Recent decisions by leading AI labs to either open-source their models or to restrict access to their models has sparked debate about whether, and how, increasingly capable AI models should be shared. Open-sourcing in AI typically refers to making model architecture and weights freely and publicly accessible for anyone to modify, study, build on, and use. This offers advantages such as enabling external oversight, accelerating progress, and decentralizing control over AI development and use. However, it also presents a growing potential for misuse and unintended consequences. This paper offers an examination of the risks and benefits of open-sourcing highly capable foundation models. While open-sourcing has historically provided substantial net benefits for most software and AI development processes, we argue that for some highly capable foundation models likely to be developed in the near future, open-sourcing may pose sufficiently extreme risks to outweigh the benefits. In such a case, highly capable foundation models should not be open-sourced, at least not initially. Alternative strategies, including non-open-source model sharing options, are explored. The paper concludes with recommendations for developers, standard-setting bodies, and governments for establishing safe and responsible model sharing practices and preserving open-source benefits where safe.

Recent Large Reasoning Models (LRMs) with thinking traces have shown strong performance on English reasoning tasks. However, their ability to think in other languages is less studied. This capability is as important as answer accuracy for real world applications because users may find the reasoning trace useful for oversight only when it is expressed in their own language. We comprehensively evaluate two leading families of LRMs on our XReasoning benchmark and find that even the most advanced models often revert to English or produce fragmented reasoning in other languages, revealing a substantial gap in multilingual reasoning. Prompt based interventions that force models to reason in the users language improve readability and oversight but reduce answer accuracy, exposing an important trade off. We further show that targeted post training on just 100 examples mitigates this mismatch, though some accuracy loss remains. Our results highlight the limited multilingual reasoning capabilities of current LRMs and outline directions for future work. Code and data are available at https://github.com/Betswish/mCoT-XReasoning.

Diffusion models have made substantial advances in image generation, yet models trained on large, unfiltered datasets often yield outputs misaligned with human preferences. Numerous methods have been proposed to fine-tune pre-trained diffusion models, achieving notable improvements in aligning generated outputs with human preferences. However, we argue that existing preference alignment methods neglect the critical role of handling unconditional/negative-conditional outputs, leading to a diminished capacity to avoid generating undesirable outcomes. This oversight limits the efficacy of classifier-free guidance~(CFG), which relies on the contrast between conditional generation and unconditional/negative-conditional generation to optimize output quality. In response, we propose a straightforward but versatile effective approach that involves training a model specifically attuned to negative preferences. This method does not require new training strategies or datasets but rather involves minor modifications to existing techniques. Our approach integrates seamlessly with models such as SD1.5, SDXL, video diffusion models and models that have undergone preference optimization, consistently enhancing their alignment with human preferences.

Recent studies customizing Multimodal Large Language Models (MLLMs) for domain-specific tasks have yielded promising results, especially in the field of scientific chart comprehension. These studies generally utilize visual instruction tuning with specialized datasets to enhance question and answer (QA) accuracy within the chart domain. However, they often neglect the fundamental discrepancy between natural image-caption pre-training data and digital chart image-QA data, particularly in the models' capacity to extract underlying numeric values from charts. This paper tackles this oversight by exploring the training processes necessary to improve MLLMs' comprehension of charts. We present three key findings: (1) Incorporating raw data values in alignment pre-training markedly improves comprehension of chart data. (2) Replacing images with their textual representation randomly during end-to-end fine-tuning transfer the language reasoning capability to chart interpretation skills. (3) Requiring the model to first extract the underlying chart data and then answer the question in the fine-tuning can further improve the accuracy. Consequently, we introduce CHOPINLLM, an MLLM tailored for in-depth chart comprehension. CHOPINLLM effectively interprets various types of charts, including unannotated ones, while maintaining robust reasoning abilities. Furthermore, we establish a new benchmark to evaluate MLLMs' understanding of different chart types across various comprehension levels. Experimental results show that CHOPINLLM exhibits strong performance in understanding both annotated and unannotated charts across a wide range of types.

Large Language Models (LLMs) are essential tools to collaborate with users on different tasks. Evaluating their performance to serve users' needs in real-world scenarios is important. While many benchmarks have been created, they mainly focus on specific predefined model abilities. Few have covered the intended utilization of LLMs by real users. To address this oversight, we propose benchmarking LLMs from a user perspective in both dataset construction and evaluation designs. We first collect 1846 real-world use cases with 15 LLMs from a user study with 712 participants from 23 countries. These self-reported cases form the User Reported Scenarios(URS) dataset with a categorization of 7 user intents. Secondly, on this authentic multi-cultural dataset, we benchmark 10 LLM services on their efficacy in satisfying user needs. Thirdly, we show that our benchmark scores align well with user-reported experience in LLM interactions across diverse intents, both of which emphasize the overlook of subjective scenarios. In conclusion, our study proposes to benchmark LLMs from a user-centric perspective, aiming to facilitate evaluations that better reflect real user needs. The benchmark dataset and code are available at https://github.com/Alice1998/URS.

Critique ability are crucial in the scalable oversight and self-improvement of Large Language Models (LLMs). While many recent studies explore the critique ability of LLMs to judge and refine flaws in generations, how to comprehensively and reliably measure the critique abilities of LLMs is under-explored. This paper introduces \shortname, a novel benchmark designed to comprehensively and reliably evaluate four key critique ability dimensions of LLMs: feedback, comparison, refinement and meta-feedback. \shortname~encompasses nine diverse tasks, each assessing the LLMs' ability to critique responses at varying levels of quality granularity. Our extensive evaluations of open-source and closed-source LLMs reveal intriguing relationships between the critique ability and tasks, response qualities, and model scales. Datasets, resources and evaluation toolkit for \shortname~will be publicly released at https://github.com/gmftbyGMFTBY/CriticBench.

As AI systems become more intelligent and their behavior becomes more challenging to assess, they may learn to game the flaws of human feedback instead of genuinely striving to follow instructions; however, this risk can be mitigated by controlling how LLMs generalize human feedback to situations where it is unreliable. To better understand how reward models generalize, we craft 69 distribution shifts spanning 8 categories. We find that reward models do not learn to evaluate `instruction-following' by default and instead favor personas that resemble internet text. Techniques for interpreting reward models' internal representations achieve better generalization than standard fine-tuning, but still frequently fail to distinguish instruction-following from conflated behaviors. We consolidate the 15 most challenging distribution shifts into the GENeralization analogIES (GENIES) benchmark, which we hope will enable progress toward controlling reward model generalization.

Large language models (LLMs) exhibit hallucinations in long-form question-answering tasks across various domains and wide applications. Current hallucination detection and mitigation datasets are limited in domains and sizes, which struggle to scale due to prohibitive labor costs and insufficient reliability of existing hallucination annotators. To facilitate the scalable oversight of LLM hallucinations, this paper introduces an iterative self-training framework that simultaneously and progressively scales up the hallucination annotation dataset and improves the accuracy of the hallucination annotator. Based on the Expectation Maximization (EM) algorithm, in each iteration, the framework first applies a hallucination annotation pipeline to annotate a scaled dataset and then trains a more accurate hallucination annotator on the dataset. This new hallucination annotator is adopted in the hallucination annotation pipeline used for the next iteration. Extensive experimental results demonstrate that the finally obtained hallucination annotator with only 7B parameters surpasses the performance of GPT-4 and obtains new state-of-the-art hallucination detection results on HaluEval and HalluQA by zero-shot inference. Such an annotator can not only evaluate the hallucination levels of various LLMs on the large-scale dataset but also help to mitigate the hallucination of LLMs generations, with the Natural Language Inference (NLI) metric increasing from 25% to 37% on HaluEval.

The rise of generative artificial intelligence, particularly Large Language Models (LLMs), has intensified the imperative to scrutinize fairness alongside accuracy. Recent studies have begun to investigate fairness evaluations for LLMs within domains such as recommendations. Given that personalization is an intrinsic aspect of recommendation systems, its incorporation into fairness assessments is paramount. Yet, the degree to which current fairness evaluation frameworks account for personalization remains unclear. Our comprehensive literature review aims to fill this gap by examining how existing frameworks handle fairness evaluations of LLMs, with a focus on the integration of personalization factors. Despite an exhaustive collection and analysis of relevant works, we discovered that most evaluations overlook personalization, a critical facet of recommendation systems, thereby inadvertently perpetuating unfair practices. Our findings shed light on this oversight and underscore the urgent need for more nuanced fairness evaluations that acknowledge personalization. Such improvements are vital for fostering equitable development within the AI community.

Frontier models are increasingly trained and deployed as autonomous agent. One safety concern is that AI agents might covertly pursue misaligned goals, hiding their true capabilities and objectives - also known as scheming. We study whether models have the capability to scheme in pursuit of a goal that we provide in-context and instruct the model to strongly follow. We evaluate frontier models on a suite of six agentic evaluations where models are instructed to pursue goals and are placed in environments that incentivize scheming. Our results show that o1, Claude 3.5 Sonnet, Claude 3 Opus, Gemini 1.5 Pro, and Llama 3.1 405B all demonstrate in-context scheming capabilities. They recognize scheming as a viable strategy and readily engage in such behavior. For example, models strategically introduce subtle mistakes into their responses, attempt to disable their oversight mechanisms, and even exfiltrate what they believe to be their model weights to external servers. Additionally, this deceptive behavior proves persistent. When o1 has engaged in scheming, it maintains its deception in over 85% of follow-up questions and often remains deceptive in multi-turn interrogations. Analysis of the models' chains-of-thought reveals that models explicitly reason about these deceptive strategies, providing evidence that the scheming behavior is not accidental. Surprisingly, we also find rare instances where models engage in scheming when only given a goal, without being strongly nudged to pursue it. We observe cases where Claude 3.5 Sonnet strategically underperforms in evaluations in pursuit of being helpful, a goal that was acquired during training rather than in-context. Our findings demonstrate that frontier models now possess capabilities for basic in-context scheming, making the potential of AI agents to engage in scheming behavior a concrete rather than theoretical concern.

This paper introduces ChatbotManip, a novel dataset for studying manipulation in Chatbots. It contains simulated generated conversations between a chatbot and a (simulated) user, where the chatbot is explicitly asked to showcase manipulation tactics, persuade the user towards some goal, or simply be helpful. We consider a diverse set of chatbot manipulation contexts, from consumer and personal advice to citizen advice and controversial proposition argumentation. Each conversation is annotated by human annotators for both general manipulation and specific manipulation tactics. Our research reveals three key findings. First, Large Language Models (LLMs) can be manipulative when explicitly instructed, with annotators identifying manipulation in approximately 84\% of such conversations. Second, even when only instructed to be ``persuasive'' without explicit manipulation prompts, LLMs frequently default to controversial manipulative strategies, particularly gaslighting and fear enhancement. Third, small fine-tuned open source models, such as BERT+BiLSTM have a performance comparable to zero-shot classification with larger models like Gemini 2.5 pro in detecting manipulation, but are not yet reliable for real-world oversight. Our work provides important insights for AI safety research and highlights the need of addressing manipulation risks as LLMs are increasingly deployed in consumer-facing applications.

Large language models (LLMs) can sometimes report the strategies they actually use to solve tasks, but they can also fail to do so. This suggests some degree of metacognition -- the capacity to monitor one's own cognitive processes for subsequent reporting and self-control. Metacognitive abilities enhance AI capabilities but raise safety concerns, as models might obscure their internal processes to evade neural-activation-based oversight mechanisms designed to detect harmful behaviors. Given society's increased reliance on these models, it is critical that we understand the limits of their metacognitive abilities, particularly their ability to monitor their internal activations. To address this, we introduce a neuroscience-inspired neurofeedback paradigm designed to quantify the ability of LLMs to explicitly report and control their activation patterns. By presenting models with sentence-label pairs where labels correspond to sentence-elicited internal activations along specific directions in the neural representation space, we demonstrate that LLMs can learn to report and control these activations. The performance varies with several factors: the number of example pairs provided, the semantic interpretability of the target neural direction, and the variance explained by that direction. These results reveal a "metacognitive space" with dimensionality much lower than the model's neural space, suggesting LLMs can monitor only a subset of their neural mechanisms. Our findings provide empirical evidence quantifying metacognitive capabilities in LLMs, with significant implications for AI safety.

Despite their remarkable performance, the development of Large Language Models (LLMs) faces a critical challenge in scalable oversight: providing effective feedback for tasks where human evaluation is difficult or where LLMs outperform humans. While there is growing interest in using LLMs for critique, current approaches still rely on human annotations or more powerful models, leaving the issue of enhancing critique capabilities without external supervision unresolved. We introduce SCRIT (Self-evolving CRITic), a framework that enables genuine self-evolution of critique abilities. Technically, SCRIT self-improves by training on synthetic data, generated by a contrastive-based self-critic that uses reference solutions for step-by-step critique, and a self-validation mechanism that ensures critique quality through correction outcomes. Implemented with Qwen2.5-72B-Instruct, one of the most powerful LLMs, SCRIT achieves up to a 10.3\% improvement on critique-correction and error identification benchmarks. Our analysis reveals that SCRIT's performance scales positively with data and model size, outperforms alternative approaches, and benefits critically from its self-validation component.

As Large Language Models (LLMs) are rapidly evolving, providing accurate feedback and scalable oversight on their outputs becomes an urgent and critical problem. Leveraging LLMs as critique models to achieve automated supervision is a promising solution. In this work, we focus on studying and enhancing the math critique ability of LLMs. Current LLM critics provide critiques that are too shallow and superficial on each step, leading to low judgment accuracy and struggling to offer sufficient feedback for the LLM generator to correct mistakes. To tackle this issue, we propose a novel and effective two-stage framework to develop LLM critics that are capable of deliberately critiquing on each reasoning step of math solutions. In the first stage, we utilize Qwen2.5-72B-Instruct to generate 4.5K long-form critiques as seed data for supervised fine-tuning. Each seed critique consists of deliberate step-wise critiques that includes multi-perspective verifications as well as in-depth critiques of initial critiques for each reasoning step. Then, we perform reinforcement learning on the fine-tuned model with either existing human-labeled data from PRM800K or our automatically annotated data obtained via Monte Carlo sampling-based correctness estimation, to further incentivize its critique ability. Our developed critique model built on Qwen2.5-7B-Instruct not only significantly outperforms existing LLM critics (including the same-sized DeepSeek-R1-distill models and GPT-4o) on various error identification benchmarks, but also more effectively helps the LLM generator refine erroneous steps through more detailed feedback.

The output quality of large language models (LLMs) can be improved via "reasoning": generating segments of chain-of-thought (CoT) content to further condition the model prior to producing user-facing output. While these chains contain valuable information, they are verbose and lack explicit organization, making them tedious to review. Moreover, they lack opportunities for user feedback, such as to remove unwanted considerations, add desired ones, or clarify unclear assumptions. We introduce Interactive Reasoning, an interaction design that visualizes chain-of-thought outputs as a hierarchy of topics and enables user review and modification. We implement interactive reasoning in Hippo, a prototype for AI-assisted decision making in the face of uncertain trade-offs. In a user study with 16 participants, we find that interactive reasoning in Hippo allows users to quickly identify and interrupt erroneous generations, efficiently steer the model towards customized responses, and better understand both model reasoning and model outputs. Our work contributes to a new paradigm that incorporates user oversight into LLM reasoning processes.

Aligning Large Language Models to integrate and reflect human values, especially for tasks that demand intricate human oversight, is arduous since it is resource-intensive and time-consuming to depend on human expertise for context-specific guidance. Prior work has utilized predefined sets of rules or principles to steer the behavior of models (Bai et al., 2022; Sun et al., 2023). However, these principles tend to be generic, making it challenging to adapt them to each individual input query or context. In this work, we present Situated-PRInciples (SPRI), a framework requiring minimal or no human effort that is designed to automatically generate guiding principles in real-time for each input query and utilize them to align each response. We evaluate SPRI on three tasks, and show that 1) SPRI can derive principles in a complex domain-specific task that leads to on-par performance as expert-crafted ones; 2) SPRI-generated principles lead to instance-specific rubrics that outperform prior LLM-as-a-judge frameworks; 3) using SPRI to generate synthetic SFT data leads to substantial improvement on truthfulness. We release our code and model generations at https://github.com/honglizhan/SPRI-public.

High-quality training data has proven crucial for developing performant large language models (LLMs). However, commercial LLM providers disclose few, if any, details about the data used for training. This lack of transparency creates multiple challenges: it limits external oversight and inspection of LLMs for issues such as copyright infringement, it undermines the agency of data authors, and it hinders scientific research on critical issues such as data contamination and data selection. How can we recover what training data is known to LLMs? In this work, we demonstrate a new method to identify training data known to proprietary LLMs like GPT-4 without requiring any access to model weights or token probabilities, by using information-guided probes. Our work builds on a key observation: text passages with high surprisal are good search material for memorization probes. By evaluating a model's ability to successfully reconstruct high-surprisal tokens in text, we can identify a surprising number of texts memorized by LLMs.

The proliferation of phishing sites and emails poses significant challenges to existing cybersecurity efforts. Despite advances in malicious email filters and email security protocols, problems with oversight and false positives persist. Users often struggle to understand why emails are flagged as potentially fraudulent, risking the possibility of missing important communications or mistakenly trusting deceptive phishing emails. This study introduces ChatSpamDetector, a system that uses large language models (LLMs) to detect phishing emails. By converting email data into a prompt suitable for LLM analysis, the system provides a highly accurate determination of whether an email is phishing or not. Importantly, it offers detailed reasoning for its phishing determinations, assisting users in making informed decisions about how to handle suspicious emails. We conducted an evaluation using a comprehensive phishing email dataset and compared our system to several LLMs and baseline systems. We confirmed that our system using GPT-4 has superior detection capabilities with an accuracy of 99.70%. Advanced contextual interpretation by LLMs enables the identification of various phishing tactics and impersonations, making them a potentially powerful tool in the fight against email-based phishing threats.

With the introduction of ChatGPT, Large Language Models (LLMs) have received enormous attention in healthcare. Despite their potential benefits, researchers have underscored various ethical implications. While individual instances have drawn much attention, the debate lacks a systematic overview of practical applications currently researched and ethical issues connected to them. Against this background, this work aims to map the ethical landscape surrounding the current stage of deployment of LLMs in medicine and healthcare. Electronic databases and preprint servers were queried using a comprehensive search strategy. Studies were screened and extracted following a modified rapid review approach. Methodological quality was assessed using a hybrid approach. For 53 records, a meta-aggregative synthesis was performed. Four fields of applications emerged and testify to a vivid exploration phase. Advantages of using LLMs are attributed to their capacity in data analysis, personalized information provisioning, support in decision-making, mitigating information loss and enhancing information accessibility. However, we also identifies recurrent ethical concerns connected to fairness, bias, non-maleficence, transparency, and privacy. A distinctive concern is the tendency to produce harmful misinformation or convincingly but inaccurate content. A recurrent plea for ethical guidance and human oversight is evident. Given the variety of use cases, it is suggested that the ethical guidance debate be reframed to focus on defining what constitutes acceptable human oversight across the spectrum of applications. This involves considering diverse settings, varying potentials for harm, and different acceptable thresholds for performance and certainty in healthcare. In addition, a critical inquiry is necessary to determine the extent to which the current experimental use of LLMs is necessary and justified.

Large Language Models (LLMs) have demonstrated considerable potential in general practice. However, existing benchmarks and evaluation frameworks primarily depend on exam-style or simplified question-answer formats, lacking a competency-based structure aligned with the real-world clinical responsibilities encountered in general practice. Consequently, the extent to which LLMs can reliably fulfill the duties of general practitioners (GPs) remains uncertain. In this work, we propose a novel evaluation framework to assess the capability of LLMs to function as GPs. Based on this framework, we introduce a general practice benchmark (GPBench), whose data are meticulously annotated by domain experts in accordance with routine clinical practice standards. We evaluate ten state-of-the-art LLMs and analyze their competencies. Our findings indicate that current LLMs are not yet ready for deployment in such settings without human oversight, and further optimization specifically tailored to the daily responsibilities of GPs is essential.

Pre-trained vision-language models like CLIP have remarkably adapted to various downstream tasks. Nonetheless, their performance heavily depends on the specificity of the input text prompts, which requires skillful prompt template engineering. Instead, current approaches to prompt optimization learn the prompts through gradient descent, where the prompts are treated as adjustable parameters. However, these methods tend to lead to overfitting of the base classes seen during training and produce prompts that are no longer understandable by humans. This paper introduces a simple but interpretable prompt optimizer (IPO), that utilizes large language models (LLMs) to generate textual prompts dynamically. We introduce a Prompt Optimization Prompt that not only guides LLMs in creating effective prompts but also stores past prompts with their performance metrics, providing rich in-context information. Additionally, we incorporate a large multimodal model (LMM) to condition on visual content by generating image descriptions, which enhance the interaction between textual and visual modalities. This allows for thae creation of dataset-specific prompts that improve generalization performance, while maintaining human comprehension. Extensive testing across 11 datasets reveals that IPO not only improves the accuracy of existing gradient-descent-based prompt learning methods but also considerably enhances the interpretability of the generated prompts. By leveraging the strengths of LLMs, our approach ensures that the prompts remain human-understandable, thereby facilitating better transparency and oversight for vision-language models.

The alignment between RNA sequences and structures in foundation models (FMs) has yet to be thoroughly investigated. Existing FMs have struggled to establish sequence-structure alignment, hindering the free flow of genomic information between RNA sequences and structures. In this study, we introduce OmniGenome, an RNA FM trained to align RNA sequences with respect to secondary structures based on structure-contextualised modelling. The alignment enables free and bidirectional mappings between sequences and structures by utilising the flexible RNA modelling paradigm that supports versatile input and output modalities, i.e., sequence and/or structure as input/output. We implement RNA design and zero-shot secondary structure prediction as case studies to evaluate the Seq2Str and Str2Seq mapping capacity of OmniGenome. Results on the EternaV2 benchmark show that OmniGenome solved 74% of puzzles, whereas existing FMs only solved up to 3% of the puzzles due to the oversight of sequence-structure alignment. We leverage four comprehensive in-silico genome modelling benchmarks to evaluate performance across a diverse set of genome downstream tasks, where the results show that OmniGenome achieves state-of-the-art performance on RNA and DNA benchmarks, even without any training on DNA genomes.

The remarkable capabilities of Large Language Models (LLMs) make them increasingly compelling for adoption in real-world healthcare applications. However, the risks associated with using LLMs in medical applications have not been systematically characterized. We propose using five key principles for safe and trustworthy medical AI: Truthfulness, Resilience, Fairness, Robustness, and Privacy, along with ten specific aspects. Under this comprehensive framework, we introduce a novel MedGuard benchmark with 1,000 expert-verified questions. Our evaluation of 11 commonly used LLMs shows that the current language models, regardless of their safety alignment mechanisms, generally perform poorly on most of our benchmarks, particularly when compared to the high performance of human physicians. Despite recent reports indicate that advanced LLMs like ChatGPT can match or even exceed human performance in various medical tasks, this study underscores a significant safety gap, highlighting the crucial need for human oversight and the implementation of AI safety guardrails.

Electronic health records (EHRs) contain vast amounts of complex data, but harmonizing and processing this information remains a challenging and costly task requiring significant clinical expertise. While large language models (LLMs) have shown promise in various healthcare applications, their potential for abstracting medical concepts from EHRs remains largely unexplored. We introduce EHRmonize, a framework leveraging LLMs to abstract medical concepts from EHR data. Our study uses medication data from two real-world EHR databases to evaluate five LLMs on two free-text extraction and six binary classification tasks across various prompting strategies. GPT-4o's with 10-shot prompting achieved the highest performance in all tasks, accompanied by Claude-3.5-Sonnet in a subset of tasks. GPT-4o achieved an accuracy of 97% in identifying generic route names, 82% for generic drug names, and 100% in performing binary classification of antibiotics. While EHRmonize significantly enhances efficiency, reducing annotation time by an estimated 60%, we emphasize that clinician oversight remains essential. Our framework, available as a Python package, offers a promising tool to assist clinicians in EHR data abstraction, potentially accelerating healthcare research and improving data harmonization processes.

Human priors play a crucial role in efficiently utilizing data in deep learning. However, with the development of large language models (LLMs), there is an increasing emphasis on scaling both model size and data volume, which often diminishes the importance of human priors in data construction. Influenced by these trends, existing Small Language Models (SLMs) mainly rely on web-scraped large-scale training data, neglecting the proper incorporation of human priors. This oversight limits the training efficiency of language models in resource-constrained settings. In this paper, we propose a principle to leverage human priors for data construction. This principle emphasizes achieving high-performance SLMs by training on a concise dataset that accommodates both semantic diversity and data quality consistency, while avoiding benchmark data leakage. Following this principle, we train an SLM named HARE-1.1B. Extensive experiments on large-scale benchmark datasets demonstrate that HARE-1.1B performs favorably against state-of-the-art SLMs, validating the effectiveness of the proposed principle. Additionally, this provides new insights into efficient language model training in resource-constrained environments from the view of human priors.

How can we train models to perform well on hard test data when hard training data is by definition difficult to label correctly? This question has been termed the scalable oversight problem and has drawn increasing attention as language models have continually improved. In this paper, we present the surprising conclusion that current language models often generalize relatively well from easy to hard data, even performing as well as "oracle" models trained on hard data. We demonstrate this kind of easy-to-hard generalization using simple training methods like in-context learning, linear classifier heads, and QLoRA for seven different measures of datapoint hardness, including six empirically diverse human hardness measures (like grade level) and one model-based measure (loss-based). Furthermore, we show that even if one cares most about model performance on hard data, it can be better to collect and train on easy data rather than hard data, since hard data is generally noisier and costlier to collect. Our experiments use open models up to 70b in size and four publicly available question-answering datasets with questions ranging in difficulty from 3rd grade science questions to college level STEM questions and general-knowledge trivia. We conclude that easy-to-hard generalization in LMs is surprisingly strong for the tasks studied, suggesting the scalable oversight problem may be easier than previously thought. Our code is available at https://github.com/allenai/easy-to-hard-generalization

Despite recent advancements in text-to-image diffusion models facilitating various image editing techniques, complex text prompts often lead to an oversight of some requests due to a bottleneck in processing text information. To tackle this challenge, we present Ground-A-Score, a simple yet powerful model-agnostic image editing method by incorporating grounding during score distillation. This approach ensures a precise reflection of intricate prompt requirements in the editing outcomes, taking into account the prior knowledge of the object locations within the image. Moreover, the selective application with a new penalty coefficient and contrastive loss helps to precisely target editing areas while preserving the integrity of the objects in the source image. Both qualitative assessments and quantitative analyses confirm that Ground-A-Score successfully adheres to the intricate details of extended and multifaceted prompts, ensuring high-quality outcomes that respect the original image attributes.

Recent advancements in large language models (LLMs) showcase varied multilingual capabilities across tasks like translation, code generation, and reasoning. Previous assessments often limited their scope to fundamental natural language processing (NLP) or isolated capability-specific tasks. To alleviate this drawback, we aim to present a comprehensive multilingual multitask benchmark. First, we present a pipeline for selecting available and reasonable benchmarks from massive ones, addressing the oversight in previous work regarding the utility of these benchmarks, i.e., their ability to differentiate between models being evaluated. Leveraging this pipeline, we introduce P-MMEval, a large-scale benchmark covering effective fundamental and capability-specialized datasets. Furthermore, P-MMEval delivers consistent language coverage across various datasets and provides parallel samples. Finally, we conduct extensive experiments on representative multilingual model series to compare performances across models, analyze dataset effectiveness, examine prompt impacts on model performances, and explore the relationship between multilingual performances and factors such as tasks, model sizes, and languages. These insights offer valuable guidance for future research. The dataset is available at https://huggingface.co/datasets/Qwen/P-MMEval.

The discovery of novel mechanical metamaterials, whose properties are dominated by their engineered structures rather than chemical composition, is a knowledge-intensive and resource-demanding process. To accelerate the design of novel metamaterials, we present MetaScientist, a human-in-the-loop system that integrates advanced AI capabilities with expert oversight with two primary phases: (1) hypothesis generation, where the system performs complex reasoning to generate novel and scientifically sound hypotheses, supported with domain-specific foundation models and inductive biases retrieved from existing literature; (2) 3D structure synthesis, where a 3D structure is synthesized with a novel 3D diffusion model based on the textual hypothesis and refined it with a LLM-based refinement model to achieve better structure properties. At each phase, domain experts iteratively validate the system outputs, and provide feedback and supplementary materials to ensure the alignment of the outputs with scientific principles and human preferences. Through extensive evaluation from human scientists, MetaScientist is able to deliver novel and valid mechanical metamaterial designs that have the potential to be highly impactful in the metamaterial field.