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  1. DrugInteraction.owl +399 -0
  2. LICENSE +201 -0
  3. Notebooks/DrugInteraction.owl +72 -0
  4. Notebooks/Final/test_with_input.ipynb +207 -0
  5. Notebooks/sparql.ipynb +169 -0
  6. Notebooks/testOnto.ipynb +320 -0
  7. README.md +124 -12
  8. agents/__init__.py +4 -0
  9. agents/__pycache__/__init__.cpython-312.pyc +0 -0
  10. agents/__pycache__/alternative_agent.cpython-312.pyc +0 -0
  11. agents/__pycache__/base_agent.cpython-312.pyc +0 -0
  12. agents/__pycache__/conflict_agent.cpython-312.pyc +0 -0
  13. agents/__pycache__/interaction_agent.cpython-312.pyc +0 -0
  14. agents/__pycache__/similarity_agent.cpython-312.pyc +0 -0
  15. agents/alternative_agent.py +22 -0
  16. agents/base_agent.py +23 -0
  17. agents/conflict_agent.py +22 -0
  18. agents/interaction_agent.py +22 -0
  19. agents/similarity_agent.py +22 -0
  20. analyzers/__init__.py +1 -0
  21. analyzers/__pycache__/__init__.cpython-312.pyc +0 -0
  22. analyzers/__pycache__/drug_interaction_analyzer.cpython-312.pyc +0 -0
  23. analyzers/drug_interaction_analyzer.py +89 -0
  24. app.py +159 -0
  25. appcli.py +171 -0
  26. img/img.png +0 -0
  27. ontology/DrugInteraction.owl +399 -0
  28. requirements.txt +7 -0
DrugInteraction.owl ADDED
@@ -0,0 +1,399 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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+ <?xml version="1.0" encoding="UTF-8"?>
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+ <rdf:RDF
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+ xmlns="http://www.example.org/DrugInteraction.owl#"
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+ xmlns:owl="http://www.w3.org/2002/07/owl#"
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+ xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
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+ xmlns:xml="http://www.w3.org/XML/1998/namespace"
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+ xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
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+ xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#">
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+
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+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#">
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+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#Ontology"/>
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+ <rdfs:comment>
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+ Ontology capturing Drug Interactions, Alternatives, Conflicts, and Similarities.
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+ </rdfs:comment>
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+ </rdf:Description>
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+ <!-- -->
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+ <!-- -->
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+ <!-- ################################################################# -->
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+ <!-- # -->
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+ <!-- # Object Properties -->
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+ <!-- # -->
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+ <!-- ################################################################# -->
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+ <!-- -->
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+ <!-- -->
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+ <!-- http://www.example.org/DrugInteraction.owl#hasAlternative -->
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+
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+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#hasAlternative">
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+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#ObjectProperty"/>
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+ <rdfs:domain rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
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+ <rdfs:range rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
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+ <rdfs:label>hasAlternative</rdfs:label>
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+ </rdf:Description>
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+ <!-- -->
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+ <!-- http://www.example.org/DrugInteraction.owl#hasConflict -->
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+
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+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#hasConflict">
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+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#ObjectProperty"/>
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+ <rdfs:domain rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
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+ <rdfs:range rdf:resource="http://www.example.org/DrugInteraction.owl#Consumable"/>
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+ <rdfs:label>hasConflict</rdfs:label>
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+ </rdf:Description>
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+ <!-- -->
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+ <!-- http://www.example.org/DrugInteraction.owl#hasInteraction -->
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+
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+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#hasInteraction">
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+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#ObjectProperty"/>
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+ <rdfs:domain rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
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+ <rdfs:range rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
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+ <rdfs:label>hasInteraction</rdfs:label>
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+ </rdf:Description>
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+ <!-- -->
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+ <!-- http://www.example.org/DrugInteraction.owl#hasSimilarity -->
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+
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+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#hasSimilarity">
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+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#ObjectProperty"/>
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+ <rdfs:domain rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
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+ <rdfs:range rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
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+ <rdfs:label>hasSimilarity</rdfs:label>
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+ </rdf:Description>
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+ <!-- -->
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+ <!-- -->
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+ <!-- -->
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+ <!-- ################################################################# -->
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+ <!-- # -->
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+ <!-- # Classes -->
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+ <!-- # -->
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+ <!-- ################################################################# -->
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+ <!-- -->
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+ <!-- -->
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+ <!-- http://www.example.org/DrugInteraction.owl#AlternativeDrug -->
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+
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+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#AlternativeDrug">
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+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#Class"/>
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+ <rdfs:label>AlternativeDrug</rdfs:label>
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+ </rdf:Description>
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+ <!-- -->
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+ <!-- http://www.example.org/DrugInteraction.owl#Conflict -->
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+
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+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Conflict">
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+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#Class"/>
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+ <rdfs:label>Conflict</rdfs:label>
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+ </rdf:Description>
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+ <!-- -->
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+ <!-- http://www.example.org/DrugInteraction.owl#Consumable -->
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+
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+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Consumable">
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+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#Class"/>
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+ <rdfs:comment>consumables</rdfs:comment>
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+ </rdf:Description>
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+ <!-- -->
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+ <!-- http://www.example.org/DrugInteraction.owl#Drug -->
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+
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+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Drug">
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+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#Class"/>
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+ <rdfs:label>Drug</rdfs:label>
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+ </rdf:Description>
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+ <!-- -->
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+ <!-- http://www.example.org/DrugInteraction.owl#DrugInteraction -->
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+
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+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#DrugInteraction">
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+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#Class"/>
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+ <rdfs:label>DrugInteraction</rdfs:label>
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+ </rdf:Description>
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+ <!-- -->
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+ <!-- http://www.example.org/DrugInteraction.owl#Similarity -->
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+
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+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Similarity">
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+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#Class"/>
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+ <rdfs:label>Similarity</rdfs:label>
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+ </rdf:Description>
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+ <!-- -->
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+ <!-- -->
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+ <!-- -->
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+ <!-- ################################################################# -->
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+ <!-- # -->
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+ <!-- # Individuals -->
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+ <!-- # -->
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+ <!-- ################################################################# -->
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+ <!-- -->
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+ <!-- -->
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+ <!-- http://www.example.org/DrugInteraction.owl#Alcohol -->
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+
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+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Alcohol">
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+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
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+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Consumable"/>
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+ <rdfs:label>Alcohol</rdfs:label>
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+ </rdf:Description>
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+ <!-- -->
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+ <!-- http://www.example.org/DrugInteraction.owl#Amlodipine -->
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+
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+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Amlodipine">
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+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
133
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
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+ <hasSimilarity rdf:resource="http://www.example.org/DrugInteraction.owl#Nifedipine"/>
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+ <rdfs:label>Amlodipine</rdfs:label>
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+ </rdf:Description>
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+ <!-- -->
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+ <!-- http://www.example.org/DrugInteraction.owl#Apixaban -->
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+
140
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Apixaban">
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+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
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+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
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+ <rdfs:label>Apixaban</rdfs:label>
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+ </rdf:Description>
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+ <!-- -->
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+ <!-- http://www.example.org/DrugInteraction.owl#Aspirin -->
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+
148
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Aspirin">
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+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
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+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
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+ <rdfs:label>Aspirin</rdfs:label>
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+ </rdf:Description>
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+ <!-- -->
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+ <!-- http://www.example.org/DrugInteraction.owl#Atorvastatin -->
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+
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+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Atorvastatin">
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+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
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+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
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+ <hasConflict rdf:resource="http://www.example.org/DrugInteraction.owl#grapefruitJuice"/>
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+ <rdfs:label>Atorvastatin</rdfs:label>
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+ </rdf:Description>
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+ <!-- -->
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+ <!-- http://www.example.org/DrugInteraction.owl#Caffeine -->
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+
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+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Caffeine">
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+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
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+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Consumable"/>
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+ <rdfs:label>Caffeine</rdfs:label>
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+ </rdf:Description>
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+ <!-- -->
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+ <!-- http://www.example.org/DrugInteraction.owl#Ciprofloxacin -->
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+
173
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Ciprofloxacin">
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+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
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+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
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+ <rdfs:label>Ciprofloxacin</rdfs:label>
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+ </rdf:Description>
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+ <!-- -->
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+ <!-- http://www.example.org/DrugInteraction.owl#Clopidogrel -->
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+
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+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Clopidogrel">
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+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
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+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
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+ <hasInteraction rdf:resource="http://www.example.org/DrugInteraction.owl#Omeprazole"/>
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+ <rdfs:label>Clopidogrel</rdfs:label>
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+ </rdf:Description>
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+ <!-- -->
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+ <!-- http://www.example.org/DrugInteraction.owl#Empagliflozin -->
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+
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+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Empagliflozin">
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+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
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+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
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+ <rdfs:label>Empagliflozin</rdfs:label>
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+ </rdf:Description>
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+ <!-- -->
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+ <!-- http://www.example.org/DrugInteraction.owl#Erythromycin -->
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+
198
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Erythromycin">
199
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
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+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
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+ <rdfs:label>Erythromycin</rdfs:label>
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+ </rdf:Description>
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+ <!-- -->
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+ <!-- http://www.example.org/DrugInteraction.owl#Esomeprazole -->
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+
206
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Esomeprazole">
207
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
208
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
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+ <rdfs:label>Esomeprazole</rdfs:label>
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+ </rdf:Description>
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+ <!-- -->
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+ <!-- http://www.example.org/DrugInteraction.owl#Fluoxetine -->
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+
214
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Fluoxetine">
215
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
216
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
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+ <rdfs:label>Fluoxetine</rdfs:label>
218
+ </rdf:Description>
219
+ <!-- -->
220
+ <!-- http://www.example.org/DrugInteraction.owl#Glucophage -->
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+
222
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Glucophage">
223
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
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+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
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+ <rdfs:label>Glucophage</rdfs:label>
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+ </rdf:Description>
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+ <!-- -->
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+ <!-- http://www.example.org/DrugInteraction.owl#Ibuprofen -->
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+
230
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Ibuprofen">
231
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
232
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
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+ <hasSimilarity rdf:resource="http://www.example.org/DrugInteraction.owl#Naproxen"/>
234
+ <rdfs:label>Ibuprofen</rdfs:label>
235
+ </rdf:Description>
236
+ <!-- -->
237
+ <!-- http://www.example.org/DrugInteraction.owl#Lisinopril -->
238
+
239
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Lisinopril">
240
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
241
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
242
+ <hasAlternative rdf:resource="http://www.example.org/DrugInteraction.owl#Losartan"/>
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+ <hasInteraction rdf:resource="http://www.example.org/DrugInteraction.owl#Spironolactone"/>
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+ <rdfs:label>Lisinopril</rdfs:label>
245
+ </rdf:Description>
246
+ <!-- -->
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+ <!-- http://www.example.org/DrugInteraction.owl#Losartan -->
248
+
249
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Losartan">
250
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
251
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
252
+ <rdfs:label>Losartan</rdfs:label>
253
+ </rdf:Description>
254
+ <!-- -->
255
+ <!-- http://www.example.org/DrugInteraction.owl#Metformin -->
256
+
257
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Metformin">
258
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
259
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
260
+ <hasAlternative rdf:resource="http://www.example.org/DrugInteraction.owl#Empagliflozin"/>
261
+ <hasInteraction rdf:resource="http://www.example.org/DrugInteraction.owl#Ciprofloxacin"/>
262
+ <hasSimilarity rdf:resource="http://www.example.org/DrugInteraction.owl#Glucophage"/>
263
+ <rdfs:label>Metformin</rdfs:label>
264
+ </rdf:Description>
265
+ <!-- -->
266
+ <!-- http://www.example.org/DrugInteraction.owl#Metronidazole -->
267
+
268
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Metronidazole">
269
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
270
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
271
+ <hasConflict rdf:resource="http://www.example.org/DrugInteraction.owl#Alcohol"/>
272
+ <rdfs:label>Metronidazole</rdfs:label>
273
+ </rdf:Description>
274
+ <!-- -->
275
+ <!-- http://www.example.org/DrugInteraction.owl#Naproxen -->
276
+
277
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Naproxen">
278
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
279
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
280
+ <rdfs:label>Naproxen</rdfs:label>
281
+ </rdf:Description>
282
+ <!-- -->
283
+ <!-- http://www.example.org/DrugInteraction.owl#Nifedipine -->
284
+
285
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Nifedipine">
286
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
287
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
288
+ <rdfs:label>Nifedipine</rdfs:label>
289
+ </rdf:Description>
290
+ <!-- -->
291
+ <!-- http://www.example.org/DrugInteraction.owl#Omeprazole -->
292
+
293
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Omeprazole">
294
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
295
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
296
+ <hasAlternative rdf:resource="http://www.example.org/DrugInteraction.owl#Pantoprazole"/>
297
+ <hasSimilarity rdf:resource="http://www.example.org/DrugInteraction.owl#Esomeprazole"/>
298
+ <rdfs:label>Omeprazole</rdfs:label>
299
+ </rdf:Description>
300
+ <!-- -->
301
+ <!-- http://www.example.org/DrugInteraction.owl#Pantoprazole -->
302
+
303
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Pantoprazole">
304
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
305
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
306
+ <rdfs:label>Pantoprazole</rdfs:label>
307
+ </rdf:Description>
308
+ <!-- -->
309
+ <!-- http://www.example.org/DrugInteraction.owl#Phenelzine -->
310
+
311
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Phenelzine">
312
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
313
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
314
+ <hasConflict rdf:resource="http://www.example.org/DrugInteraction.owl#tyramineFoods"/>
315
+ <rdfs:label>Phenelzine</rdfs:label>
316
+ </rdf:Description>
317
+ <!-- -->
318
+ <!-- http://www.example.org/DrugInteraction.owl#Rosuvastatin -->
319
+
320
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Rosuvastatin">
321
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
322
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
323
+ <rdfs:label>Rosuvastatin</rdfs:label>
324
+ </rdf:Description>
325
+ <!-- -->
326
+ <!-- http://www.example.org/DrugInteraction.owl#Sertraline -->
327
+
328
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Sertraline">
329
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
330
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
331
+ <hasSimilarity rdf:resource="http://www.example.org/DrugInteraction.owl#Fluoxetine"/>
332
+ <rdfs:label>Sertraline</rdfs:label>
333
+ </rdf:Description>
334
+ <!-- -->
335
+ <!-- http://www.example.org/DrugInteraction.owl#Simvastatin -->
336
+
337
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Simvastatin">
338
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
339
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
340
+ <hasAlternative rdf:resource="http://www.example.org/DrugInteraction.owl#Rosuvastatin"/>
341
+ <hasInteraction rdf:resource="http://www.example.org/DrugInteraction.owl#Erythromycin"/>
342
+ <rdfs:label>Simvastatin</rdfs:label>
343
+ </rdf:Description>
344
+ <!-- -->
345
+ <!-- http://www.example.org/DrugInteraction.owl#Spironolactone -->
346
+
347
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Spironolactone">
348
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
349
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
350
+ <rdfs:label>Spironolactone</rdfs:label>
351
+ </rdf:Description>
352
+ <!-- -->
353
+ <!-- http://www.example.org/DrugInteraction.owl#Theophylline -->
354
+
355
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Theophylline">
356
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
357
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
358
+ <hasConflict rdf:resource="http://www.example.org/DrugInteraction.owl#Caffeine"/>
359
+ <rdfs:label>Theophylline</rdfs:label>
360
+ </rdf:Description>
361
+ <!-- -->
362
+ <!-- http://www.example.org/DrugInteraction.owl#Warfarin -->
363
+
364
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Warfarin">
365
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
366
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
367
+ <hasAlternative rdf:resource="http://www.example.org/DrugInteraction.owl#Apixaban"/>
368
+ <hasConflict rdf:resource="http://www.example.org/DrugInteraction.owl#greenLeafyVegetables"/>
369
+ <hasInteraction rdf:resource="http://www.example.org/DrugInteraction.owl#Aspirin"/>
370
+ <rdfs:label>Warfarin</rdfs:label>
371
+ </rdf:Description>
372
+ <!-- -->
373
+ <!-- http://www.example.org/DrugInteraction.owl#grapefruitJuice -->
374
+
375
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#grapefruitJuice">
376
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
377
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Consumable"/>
378
+ <rdfs:label>GrapefruitJuice</rdfs:label>
379
+ </rdf:Description>
380
+ <!-- -->
381
+ <!-- http://www.example.org/DrugInteraction.owl#greenLeafyVegetables -->
382
+
383
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#greenLeafyVegetables">
384
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
385
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Consumable"/>
386
+ <rdfs:label>GreenLeafyVegetables</rdfs:label>
387
+ </rdf:Description>
388
+ <!-- -->
389
+ <!-- http://www.example.org/DrugInteraction.owl#tyramineFoods -->
390
+
391
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#tyramineFoods">
392
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
393
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Consumable"/>
394
+ <rdfs:label>TyramineFoods</rdfs:label>
395
+ </rdf:Description>
396
+ <!-- -->
397
+ <!-- Generated by the OWL API (version 4.5.29.2024-05-13T12:11:03Z) https://github.com/owlcs/owlapi -->
398
+
399
+ </rdf:RDF>
LICENSE ADDED
@@ -0,0 +1,201 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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Notebooks/DrugInteraction.owl ADDED
@@ -0,0 +1,72 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ <?xml version="1.0"?>
2
+ <rdf:RDF xmlns="http://www.example.org/DrugInteraction.owl#"
3
+ xml:base="http://www.example.org/DrugInteraction.owl"
4
+ xmlns:owl="http://www.w3.org/2002/07/owl#"
5
+ xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
6
+ xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#">
7
+
8
+ <!-- Ontology Header -->
9
+ <owl:Ontology rdf:about="http://www.example.org/DrugInteraction.owl"/>
10
+
11
+ <!-- Classes -->
12
+ <owl:Class rdf:about="#TestProgram"/>
13
+ <owl:Class rdf:about="#Drug"/>
14
+ <owl:Class rdf:about="#Interaction"/>
15
+ <owl:Class rdf:about="#Conflict"/>
16
+ <owl:Class rdf:about="#Similarity"/>
17
+
18
+ <!-- Object Properties -->
19
+ <owl:ObjectProperty rdf:about="#causedBy">
20
+ <rdfs:domain rdf:resource="#Interaction"/>
21
+ <rdfs:range rdf:resource="#Drug"/>
22
+ </owl:ObjectProperty>
23
+
24
+ <owl:ObjectProperty rdf:about="#between">
25
+ <rdfs:domain rdf:resource="#Conflict"/>
26
+ <rdfs:range rdf:resource="#Drug"/>
27
+ </owl:ObjectProperty>
28
+
29
+ <owl:ObjectProperty rdf:about="#relatedTo">
30
+ <rdfs:domain rdf:resource="#Similarity"/>
31
+ <rdfs:range rdf:resource="#Drug"/>
32
+ </owl:ObjectProperty>
33
+
34
+ <!-- Individuals: Drugs -->
35
+ <owl:NamedIndividual rdf:about="#Warfarin">
36
+ <rdf:type rdf:resource="#Drug"/>
37
+ </owl:NamedIndividual>
38
+ <owl:NamedIndividual rdf:about="#Aspirin">
39
+ <rdf:type rdf:resource="#Drug"/>
40
+ </owl:NamedIndividual>
41
+ <owl:NamedIndividual rdf:about="#Nitroglycerin">
42
+ <rdf:type rdf:resource="#Drug"/>
43
+ </owl:NamedIndividual>
44
+ <owl:NamedIndividual rdf:about="#Sildenafil">
45
+ <rdf:type rdf:resource="#Drug"/>
46
+ </owl:NamedIndividual>
47
+
48
+ <!-- Instances: Interactions -->
49
+ <owl:NamedIndividual rdf:about="#Interaction1">
50
+ <rdf:type rdf:resource="#Interaction"/>
51
+ <causedBy rdf:resource="#Warfarin"/>
52
+ <causedBy rdf:resource="#Aspirin"/>
53
+ <rdfs:label>Warfarin and Aspirin Interaction</rdfs:label>
54
+ </owl:NamedIndividual>
55
+
56
+ <!-- Instances: Conflicts -->
57
+ <owl:NamedIndividual rdf:about="#Conflict1">
58
+ <rdf:type rdf:resource="#Conflict"/>
59
+ <between rdf:resource="#Sildenafil"/>
60
+ <between rdf:resource="#Nitroglycerin"/>
61
+ <rdfs:label>Sildenafil and Nitroglycerin Conflict</rdfs:label>
62
+ </owl:NamedIndividual>
63
+
64
+ <!-- Instances: Similarities -->
65
+ <owl:NamedIndividual rdf:about="#Similarity1">
66
+ <rdf:type rdf:resource="#Similarity"/>
67
+ <relatedTo rdf:resource="#Warfarin"/>
68
+ <relatedTo rdf:resource="#Aspirin"/>
69
+ <rdfs:label>Similarity Between Warfarin and Aspirin</rdfs:label>
70
+ </owl:NamedIndividual>
71
+
72
+ </rdf:RDF>
Notebooks/Final/test_with_input.ipynb ADDED
@@ -0,0 +1,207 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ {
2
+ "cells": [
3
+ {
4
+ "cell_type": "code",
5
+ "execution_count": 2,
6
+ "metadata": {},
7
+ "outputs": [],
8
+ "source": [
9
+ "# Install rdflib if not already installed\n",
10
+ "# !pip install rdflib\n",
11
+ "\n",
12
+ "from rdflib import Graph, Namespace"
13
+ ]
14
+ },
15
+ {
16
+ "cell_type": "code",
17
+ "execution_count": 3,
18
+ "metadata": {},
19
+ "outputs": [
20
+ {
21
+ "name": "stdout",
22
+ "output_type": "stream",
23
+ "text": [
24
+ "Loading ontology...\n",
25
+ "Ontology loaded successfully.\n",
26
+ "\n"
27
+ ]
28
+ }
29
+ ],
30
+ "source": [
31
+ "# Step 1: Load the Ontology\n",
32
+ "print(\"Loading ontology...\")\n",
33
+ "g = Graph()\n",
34
+ "g.parse(\"DrugInteraction.owl\", format=\"xml\") # Ensure your OWL file is named correctly and in the same directory\n",
35
+ "print(\"Ontology loaded successfully.\\n\")\n"
36
+ ]
37
+ },
38
+ {
39
+ "cell_type": "code",
40
+ "execution_count": 4,
41
+ "metadata": {},
42
+ "outputs": [],
43
+ "source": [
44
+ "# Query Templates\n",
45
+ "query_interactions = \"\"\"\n",
46
+ "PREFIX ns: <http://www.example.org/DrugInteraction.owl#>\n",
47
+ "SELECT ?drug1 ?drug2\n",
48
+ "WHERE {{\n",
49
+ " ?drug1 ns:hasInteraction ?drug2 .\n",
50
+ " FILTER (STR(?drug1) = \"http://www.example.org/DrugInteraction.owl#{drug}\" || \n",
51
+ " STR(?drug2) = \"http://www.example.org/DrugInteraction.owl#{drug}\")\n",
52
+ "}}\n",
53
+ "\"\"\""
54
+ ]
55
+ },
56
+ {
57
+ "cell_type": "code",
58
+ "execution_count": 5,
59
+ "metadata": {},
60
+ "outputs": [],
61
+ "source": [
62
+ "query_conflicts = \"\"\"\n",
63
+ "PREFIX ns: <http://www.example.org/DrugInteraction.owl#>\n",
64
+ "SELECT ?drug1 ?drug2\n",
65
+ "WHERE {{\n",
66
+ " ?drug1 ns:hasConflict ?drug2 .\n",
67
+ " FILTER (STR(?drug1) = \"http://www.example.org/DrugInteraction.owl#{drug}\" || \n",
68
+ " STR(?drug2) = \"http://www.example.org/DrugInteraction.owl#{drug}\")\n",
69
+ "}}\n",
70
+ "\"\"\""
71
+ ]
72
+ },
73
+ {
74
+ "cell_type": "code",
75
+ "execution_count": 6,
76
+ "metadata": {},
77
+ "outputs": [],
78
+ "source": [
79
+ "query_similarities = \"\"\"\n",
80
+ "PREFIX ns: <http://www.example.org/DrugInteraction.owl#>\n",
81
+ "SELECT ?drug1 ?drug2\n",
82
+ "WHERE {{\n",
83
+ " ?drug1 ns:hasSimilarity ?drug2 .\n",
84
+ " FILTER (STR(?drug1) = \"http://www.example.org/DrugInteraction.owl#{drug}\" || \n",
85
+ " STR(?drug2) = \"http://www.example.org/DrugInteraction.owl#{drug}\")\n",
86
+ "}}\n",
87
+ "\"\"\""
88
+ ]
89
+ },
90
+ {
91
+ "cell_type": "code",
92
+ "execution_count": 7,
93
+ "metadata": {},
94
+ "outputs": [],
95
+ "source": [
96
+ "query_alternatives = \"\"\"\n",
97
+ "PREFIX ns: <http://www.example.org/DrugInteraction.owl#>\n",
98
+ "SELECT ?drug1 ?drug2\n",
99
+ "WHERE {{\n",
100
+ " ?drug1 ns:hasAlternative ?drug2 .\n",
101
+ " FILTER (STR(?drug1) = \"http://www.example.org/DrugInteraction.owl#{drug}\" || \n",
102
+ " STR(?drug2) = \"http://www.example.org/DrugInteraction.owl#{drug}\")\n",
103
+ "}}\n",
104
+ "\"\"\""
105
+ ]
106
+ },
107
+ {
108
+ "cell_type": "code",
109
+ "execution_count": 8,
110
+ "metadata": {},
111
+ "outputs": [],
112
+ "source": [
113
+ "# Function to execute a query and print results\n",
114
+ "def run_query(query, description, drug_name):\n",
115
+ " print(f\"Results for {description} involving '{drug_name}':\")\n",
116
+ " results = g.query(query.format(drug=drug_name))\n",
117
+ " if len(results) == 0:\n",
118
+ " print(\" No results found.\\n\")\n",
119
+ " else:\n",
120
+ " for row in results:\n",
121
+ " drug1_label = row[0].split('#')[-1]\n",
122
+ " drug2_label = row[1].split('#')[-1]\n",
123
+ " print(f\" {drug1_label} → {drug2_label}\")\n",
124
+ " print(\"\\n\")\n"
125
+ ]
126
+ },
127
+ {
128
+ "cell_type": "code",
129
+ "execution_count": 9,
130
+ "metadata": {},
131
+ "outputs": [],
132
+ "source": [
133
+ "# Step 2: Accept User Input for Drug Names\n",
134
+ "def main():\n",
135
+ " print(\"Enter drug names separated by commas (e.g., Aspirin, Warfarin):\")\n",
136
+ " user_input = input(\"Drugs: \")\n",
137
+ " drug_names = [drug.strip() for drug in user_input.split(\",\") if drug.strip()]\n",
138
+ "\n",
139
+ " if not drug_names:\n",
140
+ " print(\"No drug names provided. Exiting.\")\n",
141
+ " return\n",
142
+ "\n",
143
+ " # Step 3: Run Queries for Each Drug\n",
144
+ " for drug in drug_names:\n",
145
+ " print(f\"\\n--- Checking for {drug} ---\")\n",
146
+ " run_query(query_interactions, \"Drug Interactions\", drug)\n",
147
+ " run_query(query_conflicts, \"Conflicts\", drug)\n",
148
+ " run_query(query_similarities, \"Similarities\", drug)\n",
149
+ " run_query(query_alternatives, \"Alternative Drugs\", drug)\n"
150
+ ]
151
+ },
152
+ {
153
+ "cell_type": "code",
154
+ "execution_count": 10,
155
+ "metadata": {},
156
+ "outputs": [
157
+ {
158
+ "name": "stdout",
159
+ "output_type": "stream",
160
+ "text": [
161
+ "Enter drug names separated by commas (e.g., Aspirin, Warfarin):\n",
162
+ "\n",
163
+ "--- Checking for panadol ---\n",
164
+ "Results for Drug Interactions involving 'panadol':\n",
165
+ " No results found.\n",
166
+ "\n",
167
+ "Results for Conflicts involving 'panadol':\n",
168
+ " No results found.\n",
169
+ "\n",
170
+ "Results for Similarities involving 'panadol':\n",
171
+ " No results found.\n",
172
+ "\n",
173
+ "Results for Alternative Drugs involving 'panadol':\n",
174
+ " No results found.\n",
175
+ "\n"
176
+ ]
177
+ }
178
+ ],
179
+ "source": [
180
+ "# Run the main function\n",
181
+ "if __name__ == \"__main__\":\n",
182
+ " main()"
183
+ ]
184
+ }
185
+ ],
186
+ "metadata": {
187
+ "kernelspec": {
188
+ "display_name": "Python 3",
189
+ "language": "python",
190
+ "name": "python3"
191
+ },
192
+ "language_info": {
193
+ "codemirror_mode": {
194
+ "name": "ipython",
195
+ "version": 3
196
+ },
197
+ "file_extension": ".py",
198
+ "mimetype": "text/x-python",
199
+ "name": "python",
200
+ "nbconvert_exporter": "python",
201
+ "pygments_lexer": "ipython3",
202
+ "version": "3.12.3"
203
+ }
204
+ },
205
+ "nbformat": 4,
206
+ "nbformat_minor": 2
207
+ }
Notebooks/sparql.ipynb ADDED
@@ -0,0 +1,169 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ {
2
+ "cells": [
3
+ {
4
+ "cell_type": "code",
5
+ "execution_count": 1,
6
+ "metadata": {},
7
+ "outputs": [
8
+ {
9
+ "name": "stdout",
10
+ "output_type": "stream",
11
+ "text": [
12
+ "Loading ontology...\n",
13
+ "Ontology loaded successfully.\n",
14
+ "\n"
15
+ ]
16
+ }
17
+ ],
18
+ "source": [
19
+ "# Install rdflib if not already installed\n",
20
+ "# !pip install rdflib\n",
21
+ "\n",
22
+ "from rdflib import Graph, Namespace\n",
23
+ "\n",
24
+ "# Step 1: Load the Ontology\n",
25
+ "print(\"Loading ontology...\")\n",
26
+ "g = Graph()\n",
27
+ "g.parse(\"DrugInteraction.owl\", format=\"xml\")\n",
28
+ "print(\"Ontology loaded successfully.\\n\")"
29
+ ]
30
+ },
31
+ {
32
+ "cell_type": "code",
33
+ "execution_count": 2,
34
+ "metadata": {},
35
+ "outputs": [],
36
+ "source": [
37
+ "# Define Namespace\n",
38
+ "ns = Namespace(\"http://www.example.org/DrugInteraction.owl#\")"
39
+ ]
40
+ },
41
+ {
42
+ "cell_type": "code",
43
+ "execution_count": 3,
44
+ "metadata": {},
45
+ "outputs": [],
46
+ "source": [
47
+ "# Query 1: Retrieve Drug Interactions\n",
48
+ "query_interactions = \"\"\"\n",
49
+ "PREFIX ns: <http://www.example.org/DrugInteraction.owl#>\n",
50
+ "SELECT ?interaction ?drug1 ?drug2\n",
51
+ "WHERE {\n",
52
+ " ?interaction a ns:Interaction .\n",
53
+ " ?interaction ns:causedBy ?drug1 .\n",
54
+ " ?interaction ns:causedBy ?drug2 .\n",
55
+ " FILTER (?drug1 != ?drug2)\n",
56
+ "}\n",
57
+ "\"\"\""
58
+ ]
59
+ },
60
+ {
61
+ "cell_type": "code",
62
+ "execution_count": 4,
63
+ "metadata": {},
64
+ "outputs": [],
65
+ "source": [
66
+ "# Query 2: Retrieve Conflicts\n",
67
+ "query_conflicts = \"\"\"\n",
68
+ "PREFIX ns: <http://www.example.org/DrugInteraction.owl#>\n",
69
+ "SELECT ?conflict ?drug1 ?drug2\n",
70
+ "WHERE {\n",
71
+ " ?conflict a ns:Conflict .\n",
72
+ " ?conflict ns:between ?drug1 .\n",
73
+ " ?conflict ns:between ?drug2 .\n",
74
+ " FILTER (?drug1 != ?drug2)\n",
75
+ "}\n",
76
+ "\"\"\"\n",
77
+ "\n",
78
+ "# Query 3: Retrieve Similarities\n",
79
+ "query_similarities = \"\"\"\n",
80
+ "PREFIX ns: <http://www.example.org/DrugInteraction.owl#>\n",
81
+ "SELECT ?similarity ?drug1 ?drug2\n",
82
+ "WHERE {\n",
83
+ " ?similarity a ns:Similarity .\n",
84
+ " ?similarity ns:relatedTo ?drug1 .\n",
85
+ " ?similarity ns:relatedTo ?drug2 .\n",
86
+ " FILTER (?drug1 != ?drug2)\n",
87
+ "}\n",
88
+ "\"\"\""
89
+ ]
90
+ },
91
+ {
92
+ "cell_type": "code",
93
+ "execution_count": 5,
94
+ "metadata": {},
95
+ "outputs": [],
96
+ "source": [
97
+ "# Function to run and print SPARQL query results\n",
98
+ "def run_query(query, description):\n",
99
+ " print(f\"Results for {description}:\")\n",
100
+ " results = g.query(query)\n",
101
+ " for row in results:\n",
102
+ " print(f\"{row[0]} | Drug 1: {row[1].split('#')[-1]} | Drug 2: {row[2].split('#')[-1]}\")\n",
103
+ " print(\"\\n\")\n"
104
+ ]
105
+ },
106
+ {
107
+ "cell_type": "code",
108
+ "execution_count": 6,
109
+ "metadata": {},
110
+ "outputs": [
111
+ {
112
+ "name": "stdout",
113
+ "output_type": "stream",
114
+ "text": [
115
+ "Results for Drug Interactions:\n",
116
+ "http://www.example.org/DrugInteraction.owl#Interaction1 | Drug 1: Warfarin | Drug 2: Aspirin\n",
117
+ "http://www.example.org/DrugInteraction.owl#Interaction1 | Drug 1: Aspirin | Drug 2: Warfarin\n",
118
+ "\n",
119
+ "\n",
120
+ "Results for Conflicts:\n",
121
+ "http://www.example.org/DrugInteraction.owl#Conflict1 | Drug 1: Sildenafil | Drug 2: Nitroglycerin\n",
122
+ "http://www.example.org/DrugInteraction.owl#Conflict1 | Drug 1: Nitroglycerin | Drug 2: Sildenafil\n",
123
+ "\n",
124
+ "\n",
125
+ "Results for Similarities:\n",
126
+ "http://www.example.org/DrugInteraction.owl#Similarity1 | Drug 1: Warfarin | Drug 2: Aspirin\n",
127
+ "http://www.example.org/DrugInteraction.owl#Similarity1 | Drug 1: Aspirin | Drug 2: Warfarin\n",
128
+ "\n",
129
+ "\n"
130
+ ]
131
+ }
132
+ ],
133
+ "source": [
134
+ "# Execute each query\n",
135
+ "run_query(query_interactions, \"Drug Interactions\")\n",
136
+ "run_query(query_conflicts, \"Conflicts\")\n",
137
+ "run_query(query_similarities, \"Similarities\")"
138
+ ]
139
+ },
140
+ {
141
+ "cell_type": "code",
142
+ "execution_count": null,
143
+ "metadata": {},
144
+ "outputs": [],
145
+ "source": []
146
+ }
147
+ ],
148
+ "metadata": {
149
+ "kernelspec": {
150
+ "display_name": "Python 3",
151
+ "language": "python",
152
+ "name": "python3"
153
+ },
154
+ "language_info": {
155
+ "codemirror_mode": {
156
+ "name": "ipython",
157
+ "version": 3
158
+ },
159
+ "file_extension": ".py",
160
+ "mimetype": "text/x-python",
161
+ "name": "python",
162
+ "nbconvert_exporter": "python",
163
+ "pygments_lexer": "ipython3",
164
+ "version": "3.12.3"
165
+ }
166
+ },
167
+ "nbformat": 4,
168
+ "nbformat_minor": 2
169
+ }
Notebooks/testOnto.ipynb ADDED
@@ -0,0 +1,320 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ {
2
+ "cells": [
3
+ {
4
+ "cell_type": "code",
5
+ "execution_count": 3,
6
+ "metadata": {},
7
+ "outputs": [],
8
+ "source": [
9
+ "# Install owlready2 if not installed\n",
10
+ "# !pip install owlready2\n",
11
+ "\n",
12
+ "# Import libraries\n",
13
+ "from owlready2 import *"
14
+ ]
15
+ },
16
+ {
17
+ "cell_type": "code",
18
+ "execution_count": 4,
19
+ "metadata": {},
20
+ "outputs": [
21
+ {
22
+ "name": "stdout",
23
+ "output_type": "stream",
24
+ "text": [
25
+ "Loading ontology...\n",
26
+ "Ontology loaded successfully.\n",
27
+ "\n"
28
+ ]
29
+ }
30
+ ],
31
+ "source": [
32
+ "# Step 1: Load the Ontology\n",
33
+ "print(\"Loading ontology...\")\n",
34
+ "onto = get_ontology(\"DrugInteraction.owl\").load()\n",
35
+ "print(\"Ontology loaded successfully.\\n\")"
36
+ ]
37
+ },
38
+ {
39
+ "cell_type": "code",
40
+ "execution_count": 5,
41
+ "metadata": {},
42
+ "outputs": [
43
+ {
44
+ "name": "stdout",
45
+ "output_type": "stream",
46
+ "text": [
47
+ "Classes in the ontology:\n",
48
+ "DrugInteraction.TestProgram\n",
49
+ "DrugInteraction.Drug\n",
50
+ "DrugInteraction.Interaction\n",
51
+ "DrugInteraction.Conflict\n",
52
+ "DrugInteraction.Similarity\n",
53
+ "\n",
54
+ "Object Properties in the ontology:\n",
55
+ "DrugInteraction.causedBy\n",
56
+ "DrugInteraction.between\n",
57
+ "DrugInteraction.relatedTo\n",
58
+ "\n",
59
+ "Instances of classes:\n",
60
+ "DrugInteraction.Warfarin is an instance of DrugInteraction.Drug\n",
61
+ "DrugInteraction.Aspirin is an instance of DrugInteraction.Drug\n",
62
+ "DrugInteraction.Nitroglycerin is an instance of DrugInteraction.Drug\n",
63
+ "DrugInteraction.Sildenafil is an instance of DrugInteraction.Drug\n",
64
+ "DrugInteraction.Interaction1 is an instance of DrugInteraction.Interaction\n",
65
+ "DrugInteraction.Conflict1 is an instance of DrugInteraction.Conflict\n",
66
+ "DrugInteraction.Similarity1 is an instance of DrugInteraction.Similarity\n"
67
+ ]
68
+ }
69
+ ],
70
+ "source": [
71
+ "# Step 2: Explore Ontology Structure\n",
72
+ "print(\"Classes in the ontology:\")\n",
73
+ "for cls in onto.classes():\n",
74
+ " print(cls)\n",
75
+ "\n",
76
+ "print(\"\\nObject Properties in the ontology:\")\n",
77
+ "for prop in onto.object_properties():\n",
78
+ " print(prop)\n",
79
+ "\n",
80
+ "print(\"\\nInstances of classes:\")\n",
81
+ "for ind in onto.individuals():\n",
82
+ " print(f\"{ind} is an instance of {ind.is_a[0]}\")"
83
+ ]
84
+ },
85
+ {
86
+ "cell_type": "code",
87
+ "execution_count": 6,
88
+ "metadata": {},
89
+ "outputs": [
90
+ {
91
+ "name": "stdout",
92
+ "output_type": "stream",
93
+ "text": [
94
+ "\n",
95
+ "Querying Drug Interactions:\n",
96
+ "Interaction: Interaction1, Caused By: Warfarin, Aspirin\n"
97
+ ]
98
+ }
99
+ ],
100
+ "source": [
101
+ "# Step 3: Query Relationships\n",
102
+ "print(\"\\nQuerying Drug Interactions:\")\n",
103
+ "interaction_class = onto.search_one(iri=\"*Interaction\")\n",
104
+ "for interaction in interaction_class.instances():\n",
105
+ " caused_by_drugs = [drug.name for drug in interaction.causedBy]\n",
106
+ " print(f\"Interaction: {interaction.name}, Caused By: {', '.join(caused_by_drugs)}\")\n",
107
+ " \n"
108
+ ]
109
+ },
110
+ {
111
+ "cell_type": "code",
112
+ "execution_count": 7,
113
+ "metadata": {},
114
+ "outputs": [
115
+ {
116
+ "name": "stdout",
117
+ "output_type": "stream",
118
+ "text": [
119
+ "\n",
120
+ "Querying Conflicts:\n",
121
+ "Conflict: Conflict1, Between: [DrugInteraction.Sildenafil, DrugInteraction.Nitroglycerin]\n",
122
+ "Drug: DrugInteraction.Sildenafil\n",
123
+ "Drug: DrugInteraction.Nitroglycerin\n",
124
+ "Conflict: Conflict1, Involves Drugs: Sildenafil, Nitroglycerin\n"
125
+ ]
126
+ }
127
+ ],
128
+ "source": [
129
+ "print(\"\\nQuerying Conflicts:\") \n",
130
+ "conflict_class = onto.search_one(iri=\"*Conflict\") \n",
131
+ "for conflict in conflict_class.instances(): \n",
132
+ "\tprint(f\"Conflict: {conflict.name}, Between: {conflict.between}\") \n",
133
+ "\tinvolved_drugs = [] \n",
134
+ "\tfor drug in conflict.between: \n",
135
+ "\t\tprint(f\"Drug: {drug}\") # Print the drug to see its structure \n",
136
+ "\t\ttry: \n",
137
+ "\t\t\tinvolved_drugs.append(drug.name) \n",
138
+ "\t\texcept AttributeError: \n",
139
+ "\t\t\tprint(f\"Error: 'str' object has no attribute 'name'. Drug: {drug}\") \t\t\n",
140
+ "print(f\"Conflict: {conflict.name}, Involves Drugs: {', '.join(involved_drugs)}\")\n"
141
+ ]
142
+ },
143
+ {
144
+ "cell_type": "code",
145
+ "execution_count": 8,
146
+ "metadata": {},
147
+ "outputs": [
148
+ {
149
+ "name": "stdout",
150
+ "output_type": "stream",
151
+ "text": [
152
+ "\n",
153
+ "Querying Similarities:\n",
154
+ "Similarity: Similarity1, Related Drugs: Warfarin, Aspirin\n"
155
+ ]
156
+ }
157
+ ],
158
+ "source": [
159
+ "# Querying Similarities with error handling\n",
160
+ "print(\"\\nQuerying Similarities:\")\n",
161
+ "similarity_class = onto.search_one(iri=\"*Similarity\")\n",
162
+ "\n",
163
+ "if similarity_class: # Ensure the class exists\n",
164
+ " for similarity in similarity_class.instances():\n",
165
+ " # Safely handle 'relatedTo' to avoid AttributeError\n",
166
+ " related_drugs = [\n",
167
+ " drug.name if isinstance(drug, Thing) else str(drug) \n",
168
+ " for drug in getattr(similarity, \"relatedTo\", [])\n",
169
+ " ]\n",
170
+ " print(f\"Similarity: {similarity.name}, Related Drugs: {', '.join(related_drugs)}\")\n",
171
+ "else:\n",
172
+ " print(\"Similarity class not found in the ontology.\")\n"
173
+ ]
174
+ },
175
+ {
176
+ "cell_type": "code",
177
+ "execution_count": 9,
178
+ "metadata": {},
179
+ "outputs": [
180
+ {
181
+ "name": "stderr",
182
+ "output_type": "stream",
183
+ "text": [
184
+ "* Owlready2 * Running HermiT...\n",
185
+ " java -Xmx2000M -cp /home/manith/.local/lib/python3.12/site-packages/owlready2/hermit:/home/manith/.local/lib/python3.12/site-packages/owlready2/hermit/HermiT.jar org.semanticweb.HermiT.cli.CommandLine -c -O -D -I file:////tmp/tmps4u6q73_\n"
186
+ ]
187
+ },
188
+ {
189
+ "name": "stdout",
190
+ "output_type": "stream",
191
+ "text": [
192
+ "\n",
193
+ "Reasoning complete. Checking inferred facts...\n"
194
+ ]
195
+ },
196
+ {
197
+ "name": "stderr",
198
+ "output_type": "stream",
199
+ "text": [
200
+ "* Owlready2 * HermiT took 0.49095606803894043 seconds\n",
201
+ "* Owlready * (NB: only changes on entities loaded in Python are shown, other changes are done but not listed)\n"
202
+ ]
203
+ }
204
+ ],
205
+ "source": [
206
+ "# Step 4: Test Reasoning\n",
207
+ "# Add reasoning to infer new facts based on ontology\n",
208
+ "with onto:\n",
209
+ " sync_reasoner() # Runs the HermiT reasoner\n",
210
+ "print(\"\\nReasoning complete. Checking inferred facts...\")"
211
+ ]
212
+ },
213
+ {
214
+ "cell_type": "code",
215
+ "execution_count": 10,
216
+ "metadata": {},
217
+ "outputs": [
218
+ {
219
+ "name": "stdout",
220
+ "output_type": "stream",
221
+ "text": [
222
+ "\n",
223
+ "Inferred Relationships for Interactions:\n",
224
+ "Interaction: Interaction1, Caused By: Warfarin, Aspirin\n"
225
+ ]
226
+ }
227
+ ],
228
+ "source": [
229
+ "# Re-query after reasoning\n",
230
+ "print(\"\\nInferred Relationships for Interactions:\")\n",
231
+ "for interaction in interaction_class.instances():\n",
232
+ " caused_by_drugs = [drug.name for drug in interaction.causedBy]\n",
233
+ " print(f\"Interaction: {interaction.name}, Caused By: {', '.join(caused_by_drugs)}\")"
234
+ ]
235
+ },
236
+ {
237
+ "cell_type": "code",
238
+ "execution_count": 11,
239
+ "metadata": {},
240
+ "outputs": [
241
+ {
242
+ "name": "stdout",
243
+ "output_type": "stream",
244
+ "text": [
245
+ "\n",
246
+ "Custom Query: Find interactions involving 'Warfarin'\n",
247
+ "Interaction Found: Interaction1 caused by Warfarin\n"
248
+ ]
249
+ }
250
+ ],
251
+ "source": [
252
+ "# Step 5: Custom Queries and Testing\n",
253
+ "print(\"\\nCustom Query: Find interactions involving 'Warfarin'\")\n",
254
+ "warfarin = onto.search_one(iri=\"*Warfarin\")\n",
255
+ "for interaction in interaction_class.instances():\n",
256
+ " if warfarin in interaction.causedBy:\n",
257
+ " print(f\"Interaction Found: {interaction.name} caused by Warfarin\")"
258
+ ]
259
+ },
260
+ {
261
+ "cell_type": "code",
262
+ "execution_count": 12,
263
+ "metadata": {},
264
+ "outputs": [
265
+ {
266
+ "name": "stdout",
267
+ "output_type": "stream",
268
+ "text": [
269
+ "\n",
270
+ "Custom Query: Find conflicts involving 'Nitroglycerin'\n",
271
+ "Conflict Found: Conflict1 involving Nitroglycerin\n"
272
+ ]
273
+ }
274
+ ],
275
+ "source": [
276
+ "print(\"\\nCustom Query: Find conflicts involving 'Nitroglycerin'\")\n",
277
+ "\n",
278
+ "# Dynamically find the Nitroglycerin individual\n",
279
+ "nitroglycerin = onto.search_one(iri=\"*Nitroglycerin\")\n",
280
+ "\n",
281
+ "if nitroglycerin:\n",
282
+ " # Query Conflicts and check 'between' property\n",
283
+ " for conflict in conflict_class.instances():\n",
284
+ " involved_drugs = getattr(conflict, \"between\", [])\n",
285
+ " if nitroglycerin in involved_drugs:\n",
286
+ " print(f\"Conflict Found: {conflict.name} involving Nitroglycerin\")\n",
287
+ "else:\n",
288
+ " print(\"Nitroglycerin not found in the ontology.\")\n"
289
+ ]
290
+ },
291
+ {
292
+ "cell_type": "code",
293
+ "execution_count": null,
294
+ "metadata": {},
295
+ "outputs": [],
296
+ "source": []
297
+ }
298
+ ],
299
+ "metadata": {
300
+ "kernelspec": {
301
+ "display_name": "Python 3",
302
+ "language": "python",
303
+ "name": "python3"
304
+ },
305
+ "language_info": {
306
+ "codemirror_mode": {
307
+ "name": "ipython",
308
+ "version": 3
309
+ },
310
+ "file_extension": ".py",
311
+ "mimetype": "text/x-python",
312
+ "name": "python",
313
+ "nbconvert_exporter": "python",
314
+ "pygments_lexer": "ipython3",
315
+ "version": "3.12.3"
316
+ }
317
+ },
318
+ "nbformat": 4,
319
+ "nbformat_minor": 2
320
+ }
README.md CHANGED
@@ -1,12 +1,124 @@
1
- ---
2
- title: Ontograph
3
- emoji: 💻
4
- colorFrom: red
5
- colorTo: green
6
- sdk: streamlit
7
- sdk_version: 1.41.1
8
- app_file: app.py
9
- pinned: false
10
- ---
11
-
12
- Check out the configuration reference at https://huggingface.co/docs/hub/spaces-config-reference
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ # 🌟 OntoGraph - Drug Interaction Analysis System
2
+
3
+ A sophisticated Python-based application that combines ontology reasoning with LLM capabilities to analyze drug interactions, conflicts, and alternatives. The system provides comprehensive analysis through both CLI and web interfaces.
4
+ ![alt text](img/img.png)
5
+
6
+ ## 🚀 Key Features
7
+
8
+ - Dual Interface Options:
9
+ - Web-based interface using Streamlit
10
+ - Command-line interface for direct interaction
11
+ - Comprehensive Drug Analysis:
12
+ - Drug interaction detection
13
+ - Conflict identification
14
+ - Similar drug suggestions
15
+ - Alternative medication recommendations
16
+ - Advanced Technology Stack:
17
+ - RDF/OWL ontology for knowledge representation
18
+ - Groq LLM integration for natural language processing
19
+ - Agent-based architecture using Langgraph for modular analysis
20
+ - Structured logging system
21
+
22
+ ## 🛠️ Technical Requirements
23
+
24
+ - Python 3.x
25
+ - Groq API key
26
+ - Required Python packages:
27
+ - rdflib
28
+ - langchain
29
+ - python-dotenv
30
+ - langchain-community
31
+ - langchain-groq
32
+ - langgraph
33
+ - streamlit
34
+
35
+ ## 📥 Installation
36
+
37
+ 1. Clone the repository:
38
+ ```bash
39
+ git clone https://github.com/Manithj/onto_graph.git
40
+ cd onto_graph
41
+ ```
42
+
43
+ 2. Install dependencies:
44
+ ```bash
45
+ pip install -r requirements.txt
46
+ ```
47
+
48
+ 3. Configure environment:
49
+ - Create a `.env` file in the project root
50
+ - Add your Groq API key:
51
+ ```bash
52
+ GROQ_API_KEY=your_api_key_here
53
+ ```
54
+
55
+ ## 💻 Usage
56
+
57
+ ### Web Interface
58
+ ```bash
59
+ streamlit run app.py
60
+ ```
61
+ Navigate to the displayed local URL to access the web interface.
62
+
63
+ ### Command Line Interface
64
+ ```bash
65
+ python appcli.py
66
+ ```
67
+
68
+ ## 🏗️ Project Structure
69
+
70
+ ```
71
+ onto_graph/
72
+ ├── app.py # Streamlit web interface
73
+ ├── appcli.py # Command line interface
74
+ ├── agents/ # Agent implementations
75
+ │ ├── __init__.py
76
+ │ ├── alternative_agent.py
77
+ │ ├── base_agent.py
78
+ │ ├── conflict_agent.py
79
+ │ ├── interaction_agent.py
80
+ │ └── similarity_agent.py
81
+ ├── analyzers/ # Analysis coordination
82
+ │ ├── __init__.py
83
+ │ └── drug_interaction_analyzer.py
84
+ ├── ontology/ # Knowledge base
85
+ │ └── DrugInteraction.owl
86
+ └── requirements.txt # Project dependencies
87
+ ```
88
+
89
+ ## 🔍 Features in Detail
90
+
91
+ ### Agent System
92
+ - **Base Agent**: Common functionality for ontology queries
93
+ - **Alternative Agent**: Identifies alternative medications
94
+ - **Similarity Agent**: Finds similar drugs
95
+ - **Conflict Agent**: Detects drug conflicts
96
+ - **Interaction Agent**: Analyzes drug interactions
97
+
98
+ ### Analysis Pipeline
99
+ 1. User input processing
100
+ 2. Ontology querying
101
+ 3. LLM-powered result synthesis
102
+ 4. Structured response generation
103
+
104
+ ## 🤝 Contributing
105
+
106
+ We welcome contributions! Please follow these steps:
107
+
108
+ 1. Fork the repository
109
+ 2. Create a feature branch
110
+ 3. Commit your changes
111
+ 4. Push to your branch
112
+ 5. Create a Pull Request
113
+
114
+ ## 📝 Logging
115
+
116
+ The system maintains detailed logs in `app.log`, capturing:
117
+ - Information level messages
118
+ - Warning and error states
119
+ - Query execution details
120
+ - System state changes
121
+
122
+ ## 📜 License
123
+
124
+ This project is licensed under the [Apache 2.0](LICENSE).
agents/__init__.py ADDED
@@ -0,0 +1,4 @@
 
 
 
 
 
1
+ from .alternative_agent import AlternativeAgent
2
+ from .similarity_agent import SimilarityAgent
3
+ from .conflict_agent import ConflictAgent
4
+ from .interaction_agent import InteractionAgent
agents/__pycache__/__init__.cpython-312.pyc ADDED
Binary file (386 Bytes). View file
 
agents/__pycache__/alternative_agent.cpython-312.pyc ADDED
Binary file (1.78 kB). View file
 
agents/__pycache__/base_agent.cpython-312.pyc ADDED
Binary file (1.83 kB). View file
 
agents/__pycache__/conflict_agent.cpython-312.pyc ADDED
Binary file (1.75 kB). View file
 
agents/__pycache__/interaction_agent.cpython-312.pyc ADDED
Binary file (1.78 kB). View file
 
agents/__pycache__/similarity_agent.cpython-312.pyc ADDED
Binary file (1.77 kB). View file
 
agents/alternative_agent.py ADDED
@@ -0,0 +1,22 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ from .base_agent import BaseAgent
2
+ from rdflib import Graph, Namespace
3
+ from typing import List, Dict
4
+ import logging
5
+
6
+ class AlternativeAgent(BaseAgent):
7
+ def __init__(self, rdf_graph: Graph, namespace: Namespace):
8
+ super().__init__(rdf_graph, namespace)
9
+ self.query_template = """
10
+ PREFIX ns: <http://www.example.org/DrugInteraction.owl#>
11
+ SELECT DISTINCT ?drug1 ?drug2
12
+ WHERE {{
13
+ ?drug1 ns:hasAlternative ?drug2 .
14
+ FILTER(STRENDS(str(?drug1), "#{drug}") || STRENDS(str(?drug2), "#{drug}"))
15
+ }}
16
+ """
17
+ logging.debug("AlternativeAgent initialized.")
18
+
19
+ def get_alternatives(self, drug_name: str) -> List[Dict[str, str]]:
20
+ query = self.query_template.format(drug=drug_name)
21
+ logging.info(f"Fetching alternatives for {drug_name}")
22
+ return self.query_ontology(query)
agents/base_agent.py ADDED
@@ -0,0 +1,23 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ from rdflib import Graph, Namespace, URIRef
2
+ from typing import List, Dict
3
+ import logging
4
+
5
+ class BaseAgent:
6
+ def __init__(self, rdf_graph: Graph, namespace: Namespace):
7
+ self.graph = rdf_graph
8
+ self.ns = namespace
9
+ logging.debug("BaseAgent initialized.")
10
+
11
+ def query_ontology(self, query: str) -> List[Dict[str, str]]:
12
+ """Execute a SPARQL query and return results as a list of dictionaries."""
13
+ try:
14
+ results = self.graph.query(query)
15
+ logging.debug(f"Executing query: {query}")
16
+ return [
17
+ {"drug1": str(row[0]).split('#')[-1],
18
+ "drug2": str(row[1]).split('#')[-1]}
19
+ for row in results
20
+ ]
21
+ except Exception as e:
22
+ logging.error(f"Error executing query: {e}")
23
+ return []
agents/conflict_agent.py ADDED
@@ -0,0 +1,22 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ from .base_agent import BaseAgent
2
+ from rdflib import Graph, Namespace
3
+ from typing import List, Dict
4
+ import logging
5
+
6
+ class ConflictAgent(BaseAgent):
7
+ def __init__(self, rdf_graph: Graph, namespace: Namespace):
8
+ super().__init__(rdf_graph, namespace)
9
+ self.query_template = """
10
+ PREFIX ns: <http://www.example.org/DrugInteraction.owl#>
11
+ SELECT DISTINCT ?drug1 ?drug2
12
+ WHERE {{
13
+ ?drug1 ns:hasConflict ?drug2 .
14
+ FILTER(STRENDS(str(?drug1), "#{drug}") || STRENDS(str(?drug2), "#{drug}"))
15
+ }}
16
+ """
17
+ logging.debug("ConflictAgent initialized.")
18
+
19
+ def get_conflicts(self, drug_name: str) -> List[Dict[str, str]]:
20
+ query = self.query_template.format(drug=drug_name)
21
+ logging.info(f"Fetching conflicts for {drug_name}")
22
+ return self.query_ontology(query)
agents/interaction_agent.py ADDED
@@ -0,0 +1,22 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ from .base_agent import BaseAgent
2
+ from rdflib import Graph, Namespace
3
+ from typing import List, Dict
4
+ import logging
5
+
6
+ class InteractionAgent(BaseAgent):
7
+ def __init__(self, rdf_graph: Graph, namespace: Namespace):
8
+ super().__init__(rdf_graph, namespace)
9
+ self.query_template = """
10
+ PREFIX ns: <http://www.example.org/DrugInteraction.owl#>
11
+ SELECT DISTINCT ?drug1 ?drug2
12
+ WHERE {{
13
+ ?drug1 ns:hasInteraction ?drug2 .
14
+ FILTER(STRENDS(str(?drug1), "#{drug}") || STRENDS(str(?drug2), "#{drug}"))
15
+ }}
16
+ """
17
+ logging.debug("InteractionAgent initialized.")
18
+
19
+ def get_interactions(self, drug_name: str) -> List[Dict[str, str]]:
20
+ query = self.query_template.format(drug=drug_name)
21
+ logging.info(f"Fetching interactions for {drug_name}")
22
+ return self.query_ontology(query)
agents/similarity_agent.py ADDED
@@ -0,0 +1,22 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ from .base_agent import BaseAgent
2
+ from rdflib import Graph, Namespace
3
+ from typing import List, Dict
4
+ import logging
5
+
6
+ class SimilarityAgent(BaseAgent):
7
+ def __init__(self, rdf_graph: Graph, namespace: Namespace):
8
+ super().__init__(rdf_graph, namespace)
9
+ self.query_template = """
10
+ PREFIX ns: <http://www.example.org/DrugInteraction.owl#>
11
+ SELECT DISTINCT ?drug1 ?drug2
12
+ WHERE {{
13
+ ?drug1 ns:hasSimilarity ?drug2 .
14
+ FILTER(STRENDS(str(?drug1), "#{drug}") || STRENDS(str(?drug2), "#{drug}"))
15
+ }}
16
+ """
17
+ logging.debug("SimilarityAgent initialized.")
18
+
19
+ def get_similarities(self, drug_name: str) -> List[Dict[str, str]]:
20
+ query = self.query_template.format(drug=drug_name)
21
+ logging.info(f"Fetching similarities for {drug_name}")
22
+ return self.query_ontology(query)
analyzers/__init__.py ADDED
@@ -0,0 +1 @@
 
 
1
+ from .drug_interaction_analyzer import DrugInteractionAnalyzer
analyzers/__pycache__/__init__.cpython-312.pyc ADDED
Binary file (235 Bytes). View file
 
analyzers/__pycache__/drug_interaction_analyzer.cpython-312.pyc ADDED
Binary file (5.22 kB). View file
 
analyzers/drug_interaction_analyzer.py ADDED
@@ -0,0 +1,89 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ from typing import Dict, List
2
+ import json
3
+ from agents import AlternativeAgent, SimilarityAgent, ConflictAgent, InteractionAgent
4
+ from rdflib import Graph, Namespace
5
+ import logging
6
+
7
+ class DrugInteractionAnalyzer:
8
+ """
9
+ Analyzer class to handle drug interactions, alternatives, similarities, and conflicts using separate agents.
10
+ """
11
+ def __init__(self, owl_file_path: str):
12
+ """
13
+ Initialize the DrugInteractionAnalyzer with the ontology file and instantiate agents.
14
+
15
+ Args:
16
+ owl_file_path (str): Path to the RDF/XML ontology file.
17
+ """
18
+ self.graph = Graph()
19
+ try:
20
+ self.graph.parse(owl_file_path, format="xml")
21
+ self.namespace = Namespace("http://www.example.org/DrugInteraction.owl#")
22
+ logging.info(f"Successfully loaded ontology from {owl_file_path}")
23
+ except Exception as e:
24
+ logging.error(f"Failed to load ontology file: {e}")
25
+ raise ValueError(f"Failed to load ontology file: {e}")
26
+
27
+ # Initialize agents
28
+ self.alternative_agent = AlternativeAgent(self.graph, self.namespace)
29
+ self.similarity_agent = SimilarityAgent(self.graph, self.namespace)
30
+ self.conflict_agent = ConflictAgent(self.graph, self.namespace)
31
+ self.interaction_agent = InteractionAgent(self.graph, self.namespace)
32
+ logging.info("Initialized all agents successfully.")
33
+
34
+ def analyze_drugs(self, drug_names: List[str]) -> Dict[str, Dict[str, List[Dict[str, str]]]]:
35
+ """
36
+ Analyze multiple drugs using separate agents and return structured results.
37
+
38
+ Args:
39
+ drug_names (List[str]): List of drug names to analyze.
40
+
41
+ Returns:
42
+ Dict[str, Dict[str, List[Dict[str, str]]]]: Structured analysis results.
43
+ """
44
+ results = {}
45
+ for drug in drug_names:
46
+ drug_results = {}
47
+ logging.info(f"Analyzing drug: {drug}")
48
+
49
+ # Alternatives
50
+ try:
51
+ alternatives = self.alternative_agent.get_alternatives(drug)
52
+ drug_results["alternatives"] = alternatives
53
+ logging.debug(f"Alternatives for {drug}: {alternatives}")
54
+ except Exception as e:
55
+ logging.warning(f"Failed to get alternatives for {drug}: {e}")
56
+ drug_results["alternatives"] = []
57
+
58
+ # Similarities
59
+ try:
60
+ similarities = self.similarity_agent.get_similarities(drug)
61
+ drug_results["similarities"] = similarities
62
+ logging.debug(f"Similarities for {drug}: {similarities}")
63
+ except Exception as e:
64
+ logging.warning(f"Failed to get similarities for {drug}: {e}")
65
+ drug_results["similarities"] = []
66
+
67
+ # Conflicts
68
+ try:
69
+ conflicts = self.conflict_agent.get_conflicts(drug)
70
+ drug_results["conflicts"] = conflicts
71
+ logging.debug(f"Conflicts for {drug}: {conflicts}")
72
+ except Exception as e:
73
+ logging.warning(f"Failed to get conflicts for {drug}: {e}")
74
+ drug_results["conflicts"] = []
75
+
76
+ # Interactions
77
+ try:
78
+ interactions = self.interaction_agent.get_interactions(drug)
79
+ drug_results["interactions"] = interactions
80
+ logging.debug(f"Interactions for {drug}: {interactions}")
81
+ except Exception as e:
82
+ logging.warning(f"Failed to get interactions for {drug}: {e}")
83
+ drug_results["interactions"] = []
84
+
85
+ results[drug] = drug_results
86
+ logging.info(f"Completed analysis for {drug}")
87
+
88
+ logging.info("Completed analysis for all drugs.")
89
+ return results
app.py ADDED
@@ -0,0 +1,159 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ import streamlit as st
2
+ from rdflib import Graph, Namespace, URIRef, Literal
3
+ from typing import Dict, List, Optional
4
+ from langgraph.graph import StateGraph
5
+ from langchain.prompts import ChatPromptTemplate
6
+ import json
7
+ from dotenv import load_dotenv
8
+ import os
9
+ from dataclasses import dataclass
10
+ from langchain_community.chat_models import ChatOllama
11
+ from langchain_groq import ChatGroq
12
+ import logging
13
+ from analyzers import DrugInteractionAnalyzer
14
+
15
+ # Load environment variables
16
+ load_dotenv()
17
+
18
+ # Configure logging
19
+ logging.basicConfig(
20
+ level=logging.INFO,
21
+ format='%(asctime)s [%(levelname)s] %(message)s',
22
+ handlers=[
23
+ logging.FileHandler("app.log"),
24
+ logging.StreamHandler()
25
+ ]
26
+ )
27
+
28
+ # Validating API key
29
+ GROQ_API_KEY = os.getenv("GROQ_API_KEY")
30
+ if not GROQ_API_KEY:
31
+ logging.error("GROQ_API_KEY not found in environment variables. Please add it to your .env file.")
32
+ raise ValueError("GROQ_API_KEY not found in environment variables. Please add it to your .env file.")
33
+
34
+ @dataclass
35
+ class GraphState:
36
+ """State type for the graph."""
37
+ input: str
38
+ query: Optional[str] = None
39
+ ontology_results: Optional[str] = None
40
+ response: Optional[str] = None
41
+
42
+ class OntologyAgent:
43
+ def __init__(self, owl_file_path: str):
44
+ """Initialize the OntologyAgent with an OWL file."""
45
+ self.g = Graph()
46
+ try:
47
+ self.g.parse(owl_file_path, format="xml")
48
+ self.ns = Namespace("http://www.example.org/DrugInteraction.owl#")
49
+ logging.info(f"Ontology loaded successfully from {owl_file_path}")
50
+ except Exception as e:
51
+ logging.error(f"Failed to load ontology file: {e}")
52
+ raise ValueError(f"Failed to load ontology file: {e}")
53
+
54
+ def create_agent_graph(owl_file_path: str) -> StateGraph:
55
+ """Create a processing graph for drug interaction analysis using separate agents."""
56
+ analyzer = DrugInteractionAnalyzer(owl_file_path)
57
+
58
+ def user_input_node(state: GraphState) -> Dict[str, str]:
59
+ logging.info("Processing user input.")
60
+ return {"query": state.input}
61
+
62
+ def ontology_query_node(state: GraphState) -> Dict[str, str]:
63
+ try:
64
+ logging.info("Executing ontology queries.")
65
+ drug_names = [d.strip() for d in state.input.split(",")]
66
+ results = analyzer.analyze_drugs(drug_names)
67
+ logging.info(f"Ontology query results: {results}")
68
+ return {"ontology_results": json.dumps(results, indent=2)}
69
+ except Exception as e:
70
+ logging.warning(f"Ontology query failed: {e}")
71
+ return {"ontology_results": json.dumps({"error": str(e)})}
72
+
73
+ def llm_processing_node(state: GraphState) -> Dict[str, str]:
74
+ template = """
75
+ Based on the drug interaction analysis results:
76
+ {ontology_results}
77
+
78
+ Please provide a comprehensive summary of:
79
+ 1. Direct interactions between the drugs
80
+ 2. Potential conflicts
81
+ 3. Similar drug alternatives
82
+ 4. Recommended alternatives if conflicts exist
83
+
84
+ If no results were found, please indicate this clearly.
85
+ Format the response in a clear, structured manner.
86
+ """
87
+
88
+ prompt = ChatPromptTemplate.from_template(template)
89
+
90
+ try:
91
+ llm = ChatGroq(
92
+ model_name="llama3-groq-70b-8192-tool-use-preview",
93
+ api_key=GROQ_API_KEY,
94
+ temperature=0.7
95
+ )
96
+ logging.info("LLM initialized successfully.")
97
+ except Exception as e:
98
+ logging.error(f"Error initializing LLM: {e}")
99
+ return {"response": f"Error initializing LLM: {str(e)}"}
100
+
101
+ chain = prompt | llm
102
+
103
+ try:
104
+ response = chain.invoke({
105
+ "ontology_results": state.ontology_results
106
+ })
107
+
108
+ logging.info("LLM processing completed successfully.")
109
+ return {"response": response.content}
110
+ except Exception as e:
111
+ logging.error(f"Error processing results with LLM: {e}")
112
+ return {"response": f"Error processing results: {str(e)}"}
113
+
114
+ workflow = StateGraph(GraphState)
115
+
116
+ workflow.add_node("input_processor", user_input_node)
117
+ workflow.add_node("ontology_query", ontology_query_node)
118
+ workflow.add_node("llm_processing", llm_processing_node)
119
+
120
+ workflow.add_edge("input_processor", "ontology_query")
121
+ workflow.add_edge("ontology_query", "llm_processing")
122
+
123
+ workflow.set_entry_point("input_processor")
124
+
125
+ logging.info("Agent graph created and configured successfully.")
126
+
127
+ return workflow.compile()
128
+
129
+ def main():
130
+ st.title("Drug Interaction Analysis System")
131
+
132
+ user_input = st.text_input("Enter drug names separated by commas (e.g., Aspirin, Warfarin):", value="")
133
+
134
+ if st.button("Analyze"):
135
+ if not user_input.strip():
136
+ st.warning("Please enter at least one drug name.")
137
+ return
138
+
139
+ owl_file_path = os.path.join("ontology", "DrugInteraction.owl")
140
+ if not os.path.exists(owl_file_path):
141
+ logging.error(f"Ontology file not found: {owl_file_path}")
142
+ st.error(f"Ontology file not found: {owl_file_path}")
143
+ return
144
+
145
+ try:
146
+ with st.spinner("Analyzing drug interactions..."):
147
+ agent_graph = create_agent_graph(owl_file_path)
148
+ result = agent_graph.invoke(GraphState(input=user_input))
149
+
150
+ st.subheader("Analysis Results:")
151
+ st.markdown(result["response"])
152
+
153
+ logging.info("Analysis completed and results displayed.")
154
+ except Exception as e:
155
+ logging.error(f"An error occurred: {str(e)}")
156
+ st.error(f"An error occurred: {str(e)}")
157
+
158
+ if __name__ == "__main__":
159
+ main()
appcli.py ADDED
@@ -0,0 +1,171 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+
2
+ from rdflib import Graph, Namespace, URIRef, Literal
3
+ from typing import Dict, List, Optional
4
+ from langgraph.graph import StateGraph
5
+ from langchain.prompts import ChatPromptTemplate
6
+ import json
7
+ from dotenv import load_dotenv
8
+ import os
9
+ from dataclasses import dataclass
10
+ from langchain_community.chat_models import ChatOllama
11
+ from langchain_groq import ChatGroq
12
+ import logging
13
+ # Import the DrugInteractionAnalyzer
14
+ from analyzers import DrugInteractionAnalyzer
15
+
16
+
17
+ # Load environment variables
18
+ load_dotenv()
19
+
20
+ # Configure logging
21
+ logging.basicConfig(
22
+ level=logging.INFO,
23
+ format='%(asctime)s [%(levelname)s] %(message)s',
24
+ handlers=[
25
+ logging.FileHandler("app.log"),
26
+ logging.StreamHandler()
27
+ ]
28
+ )
29
+
30
+ # Validating API key
31
+ GROQ_API_KEY = os.getenv("GROQ_API_KEY")
32
+ if not GROQ_API_KEY:
33
+ logging.error("GROQ_API_KEY not found in environment variables. Please add it to your .env file.")
34
+ raise ValueError("GROQ_API_KEY not found in environment variables. Please add it to your .env file.")
35
+
36
+ @dataclass
37
+ class GraphState:
38
+ """State type for the graph."""
39
+ input: str
40
+ query: Optional[str] = None
41
+ ontology_results: Optional[str] = None
42
+ response: Optional[str] = None
43
+
44
+ class OntologyAgent:
45
+ def __init__(self, owl_file_path: str):
46
+ """Initialize the OntologyAgent with an OWL file."""
47
+
48
+ self.g = Graph()
49
+ try:
50
+ self.g.parse(owl_file_path, format="xml")
51
+ self.ns = Namespace("http://www.example.org/DrugInteraction.owl#")
52
+ logging.info(f"Ontology loaded successfully from {owl_file_path}")
53
+ except Exception as e:
54
+ logging.error(f"Failed to load ontology file: {e}")
55
+ raise ValueError(f"Failed to load ontology file: {e}")
56
+
57
+ def create_agent_graph(owl_file_path: str) -> StateGraph:
58
+ """Create a processing graph for drug interaction analysis using separate agents."""
59
+ analyzer = DrugInteractionAnalyzer(owl_file_path)
60
+
61
+ def user_input_node(state: GraphState) -> Dict[str, str]:
62
+ logging.info("Processing user input.")
63
+
64
+ return {"query": state.input}
65
+
66
+ def ontology_query_node(state: GraphState) -> Dict[str, str]:
67
+ try:
68
+ logging.info("Executing ontology queries.")
69
+ drug_names = [d.strip() for d in state.input.split(",")]
70
+ results = analyzer.analyze_drugs(drug_names)
71
+ logging.info(f"Ontology query results: {results}")
72
+ return {"ontology_results": json.dumps(results, indent=2)}
73
+ except Exception as e:
74
+ logging.warning(f"Ontology query failed: {e}")
75
+
76
+ return {"ontology_results": json.dumps({"error": str(e)})}
77
+
78
+ def llm_processing_node(state: GraphState) -> Dict[str, str]:
79
+ template = """
80
+ Based on the drug interaction analysis results:
81
+ {ontology_results}
82
+
83
+ Please provide a comprehensive summary of:
84
+ 1. Direct interactions between the drugs
85
+ 2. Potential conflicts
86
+ 3. Similar drug alternatives
87
+ 4. Recommended alternatives if conflicts exist
88
+
89
+ If no results were found, please indicate this clearly.
90
+ Format the response in a clear, structured manner.
91
+ """
92
+
93
+ prompt = ChatPromptTemplate.from_template(template)
94
+
95
+ try:
96
+ llm = ChatGroq(
97
+ model_name="llama3-groq-70b-8192-tool-use-preview",
98
+ api_key=GROQ_API_KEY,
99
+ temperature=0.7
100
+ )
101
+ logging.info("LLM initialized successfully.")
102
+ except Exception as e:
103
+ logging.error(f"Error initializing LLM: {e}")
104
+ return {"response": f"Error initializing LLM: {str(e)}"}
105
+
106
+ chain = prompt | llm
107
+
108
+ try:
109
+ response = chain.invoke({
110
+ "ontology_results": state.ontology_results
111
+ })
112
+
113
+ logging.info("LLM processing completed successfully.")
114
+ return {"response": response.content}
115
+ except Exception as e:
116
+ logging.error(f"Error processing results with LLM: {e}")
117
+ return {"response": f"Error processing results: {str(e)}"}
118
+
119
+ # Create and configure the graph
120
+ workflow = StateGraph(GraphState)
121
+
122
+ workflow.add_node("input_processor", user_input_node)
123
+ workflow.add_node("ontology_query", ontology_query_node)
124
+ workflow.add_node("llm_processing", llm_processing_node)
125
+
126
+ workflow.add_edge("input_processor", "ontology_query")
127
+ workflow.add_edge("ontology_query", "llm_processing")
128
+
129
+ workflow.set_entry_point("input_processor")
130
+
131
+ logging.info("Agent graph created and configured successfully.")
132
+
133
+ return workflow.compile()
134
+
135
+ def main():
136
+ """Main function to run the drug interaction analysis."""
137
+ try:
138
+ logging.info("Starting Drug Interaction Analysis System.")
139
+
140
+
141
+ print("Drug Interaction Analysis System")
142
+ print("Enter drug names separated by commas (e.g., Aspirin, Warfarin):")
143
+ user_input = input("Drugs: ").strip()
144
+
145
+ if not user_input:
146
+ logging.warning("No drug names provided. Exiting.")
147
+ print("No drug names provided. Exiting.")
148
+ return
149
+
150
+ owl_file_path = os.path.join("ontology", "DrugInteraction.owl")
151
+ if not os.path.exists(owl_file_path):
152
+ logging.error(f"Ontology file not found: {owl_file_path}")
153
+
154
+ raise FileNotFoundError(f"Ontology file not found: {owl_file_path}")
155
+
156
+ agent_graph = create_agent_graph(owl_file_path)
157
+ result = agent_graph.invoke(GraphState(input=user_input))
158
+
159
+ print("\nAnalysis Results:")
160
+ print(result["response"])
161
+
162
+ logging.info("Analysis completed and results displayed.")
163
+
164
+ except Exception as e:
165
+ logging.error(f"An error occurred: {str(e)}")
166
+ print(f"An error occurred: {str(e)}")
167
+ print("Please check your input and try again.")
168
+
169
+ if __name__ == "__main__":
170
+ main()
171
+
img/img.png ADDED
ontology/DrugInteraction.owl ADDED
@@ -0,0 +1,399 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ <?xml version="1.0" encoding="UTF-8"?>
2
+ <rdf:RDF
3
+ xmlns="http://www.example.org/DrugInteraction.owl#"
4
+ xmlns:owl="http://www.w3.org/2002/07/owl#"
5
+ xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
6
+ xmlns:xml="http://www.w3.org/XML/1998/namespace"
7
+ xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
8
+ xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#">
9
+
10
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#">
11
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#Ontology"/>
12
+ <rdfs:comment>
13
+ Ontology capturing Drug Interactions, Alternatives, Conflicts, and Similarities.
14
+ </rdfs:comment>
15
+ </rdf:Description>
16
+ <!-- -->
17
+ <!-- -->
18
+ <!-- ################################################################# -->
19
+ <!-- # -->
20
+ <!-- # Object Properties -->
21
+ <!-- # -->
22
+ <!-- ################################################################# -->
23
+ <!-- -->
24
+ <!-- -->
25
+ <!-- http://www.example.org/DrugInteraction.owl#hasAlternative -->
26
+
27
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#hasAlternative">
28
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#ObjectProperty"/>
29
+ <rdfs:domain rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
30
+ <rdfs:range rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
31
+ <rdfs:label>hasAlternative</rdfs:label>
32
+ </rdf:Description>
33
+ <!-- -->
34
+ <!-- http://www.example.org/DrugInteraction.owl#hasConflict -->
35
+
36
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#hasConflict">
37
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#ObjectProperty"/>
38
+ <rdfs:domain rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
39
+ <rdfs:range rdf:resource="http://www.example.org/DrugInteraction.owl#Consumable"/>
40
+ <rdfs:label>hasConflict</rdfs:label>
41
+ </rdf:Description>
42
+ <!-- -->
43
+ <!-- http://www.example.org/DrugInteraction.owl#hasInteraction -->
44
+
45
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#hasInteraction">
46
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#ObjectProperty"/>
47
+ <rdfs:domain rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
48
+ <rdfs:range rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
49
+ <rdfs:label>hasInteraction</rdfs:label>
50
+ </rdf:Description>
51
+ <!-- -->
52
+ <!-- http://www.example.org/DrugInteraction.owl#hasSimilarity -->
53
+
54
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#hasSimilarity">
55
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#ObjectProperty"/>
56
+ <rdfs:domain rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
57
+ <rdfs:range rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
58
+ <rdfs:label>hasSimilarity</rdfs:label>
59
+ </rdf:Description>
60
+ <!-- -->
61
+ <!-- -->
62
+ <!-- -->
63
+ <!-- ################################################################# -->
64
+ <!-- # -->
65
+ <!-- # Classes -->
66
+ <!-- # -->
67
+ <!-- ################################################################# -->
68
+ <!-- -->
69
+ <!-- -->
70
+ <!-- http://www.example.org/DrugInteraction.owl#AlternativeDrug -->
71
+
72
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#AlternativeDrug">
73
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#Class"/>
74
+ <rdfs:label>AlternativeDrug</rdfs:label>
75
+ </rdf:Description>
76
+ <!-- -->
77
+ <!-- http://www.example.org/DrugInteraction.owl#Conflict -->
78
+
79
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Conflict">
80
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#Class"/>
81
+ <rdfs:label>Conflict</rdfs:label>
82
+ </rdf:Description>
83
+ <!-- -->
84
+ <!-- http://www.example.org/DrugInteraction.owl#Consumable -->
85
+
86
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Consumable">
87
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#Class"/>
88
+ <rdfs:comment>consumables</rdfs:comment>
89
+ </rdf:Description>
90
+ <!-- -->
91
+ <!-- http://www.example.org/DrugInteraction.owl#Drug -->
92
+
93
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Drug">
94
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#Class"/>
95
+ <rdfs:label>Drug</rdfs:label>
96
+ </rdf:Description>
97
+ <!-- -->
98
+ <!-- http://www.example.org/DrugInteraction.owl#DrugInteraction -->
99
+
100
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#DrugInteraction">
101
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#Class"/>
102
+ <rdfs:label>DrugInteraction</rdfs:label>
103
+ </rdf:Description>
104
+ <!-- -->
105
+ <!-- http://www.example.org/DrugInteraction.owl#Similarity -->
106
+
107
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Similarity">
108
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#Class"/>
109
+ <rdfs:label>Similarity</rdfs:label>
110
+ </rdf:Description>
111
+ <!-- -->
112
+ <!-- -->
113
+ <!-- -->
114
+ <!-- ################################################################# -->
115
+ <!-- # -->
116
+ <!-- # Individuals -->
117
+ <!-- # -->
118
+ <!-- ################################################################# -->
119
+ <!-- -->
120
+ <!-- -->
121
+ <!-- http://www.example.org/DrugInteraction.owl#Alcohol -->
122
+
123
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Alcohol">
124
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
125
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Consumable"/>
126
+ <rdfs:label>Alcohol</rdfs:label>
127
+ </rdf:Description>
128
+ <!-- -->
129
+ <!-- http://www.example.org/DrugInteraction.owl#Amlodipine -->
130
+
131
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Amlodipine">
132
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
133
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
134
+ <hasSimilarity rdf:resource="http://www.example.org/DrugInteraction.owl#Nifedipine"/>
135
+ <rdfs:label>Amlodipine</rdfs:label>
136
+ </rdf:Description>
137
+ <!-- -->
138
+ <!-- http://www.example.org/DrugInteraction.owl#Apixaban -->
139
+
140
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Apixaban">
141
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
142
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
143
+ <rdfs:label>Apixaban</rdfs:label>
144
+ </rdf:Description>
145
+ <!-- -->
146
+ <!-- http://www.example.org/DrugInteraction.owl#Aspirin -->
147
+
148
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Aspirin">
149
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
150
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
151
+ <rdfs:label>Aspirin</rdfs:label>
152
+ </rdf:Description>
153
+ <!-- -->
154
+ <!-- http://www.example.org/DrugInteraction.owl#Atorvastatin -->
155
+
156
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Atorvastatin">
157
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
158
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
159
+ <hasConflict rdf:resource="http://www.example.org/DrugInteraction.owl#grapefruitJuice"/>
160
+ <rdfs:label>Atorvastatin</rdfs:label>
161
+ </rdf:Description>
162
+ <!-- -->
163
+ <!-- http://www.example.org/DrugInteraction.owl#Caffeine -->
164
+
165
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Caffeine">
166
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
167
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Consumable"/>
168
+ <rdfs:label>Caffeine</rdfs:label>
169
+ </rdf:Description>
170
+ <!-- -->
171
+ <!-- http://www.example.org/DrugInteraction.owl#Ciprofloxacin -->
172
+
173
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Ciprofloxacin">
174
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
175
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
176
+ <rdfs:label>Ciprofloxacin</rdfs:label>
177
+ </rdf:Description>
178
+ <!-- -->
179
+ <!-- http://www.example.org/DrugInteraction.owl#Clopidogrel -->
180
+
181
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Clopidogrel">
182
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
183
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
184
+ <hasInteraction rdf:resource="http://www.example.org/DrugInteraction.owl#Omeprazole"/>
185
+ <rdfs:label>Clopidogrel</rdfs:label>
186
+ </rdf:Description>
187
+ <!-- -->
188
+ <!-- http://www.example.org/DrugInteraction.owl#Empagliflozin -->
189
+
190
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Empagliflozin">
191
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
192
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
193
+ <rdfs:label>Empagliflozin</rdfs:label>
194
+ </rdf:Description>
195
+ <!-- -->
196
+ <!-- http://www.example.org/DrugInteraction.owl#Erythromycin -->
197
+
198
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Erythromycin">
199
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
200
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
201
+ <rdfs:label>Erythromycin</rdfs:label>
202
+ </rdf:Description>
203
+ <!-- -->
204
+ <!-- http://www.example.org/DrugInteraction.owl#Esomeprazole -->
205
+
206
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Esomeprazole">
207
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
208
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
209
+ <rdfs:label>Esomeprazole</rdfs:label>
210
+ </rdf:Description>
211
+ <!-- -->
212
+ <!-- http://www.example.org/DrugInteraction.owl#Fluoxetine -->
213
+
214
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Fluoxetine">
215
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
216
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
217
+ <rdfs:label>Fluoxetine</rdfs:label>
218
+ </rdf:Description>
219
+ <!-- -->
220
+ <!-- http://www.example.org/DrugInteraction.owl#Glucophage -->
221
+
222
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Glucophage">
223
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
224
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
225
+ <rdfs:label>Glucophage</rdfs:label>
226
+ </rdf:Description>
227
+ <!-- -->
228
+ <!-- http://www.example.org/DrugInteraction.owl#Ibuprofen -->
229
+
230
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Ibuprofen">
231
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
232
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
233
+ <hasSimilarity rdf:resource="http://www.example.org/DrugInteraction.owl#Naproxen"/>
234
+ <rdfs:label>Ibuprofen</rdfs:label>
235
+ </rdf:Description>
236
+ <!-- -->
237
+ <!-- http://www.example.org/DrugInteraction.owl#Lisinopril -->
238
+
239
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Lisinopril">
240
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
241
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
242
+ <hasAlternative rdf:resource="http://www.example.org/DrugInteraction.owl#Losartan"/>
243
+ <hasInteraction rdf:resource="http://www.example.org/DrugInteraction.owl#Spironolactone"/>
244
+ <rdfs:label>Lisinopril</rdfs:label>
245
+ </rdf:Description>
246
+ <!-- -->
247
+ <!-- http://www.example.org/DrugInteraction.owl#Losartan -->
248
+
249
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Losartan">
250
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
251
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
252
+ <rdfs:label>Losartan</rdfs:label>
253
+ </rdf:Description>
254
+ <!-- -->
255
+ <!-- http://www.example.org/DrugInteraction.owl#Metformin -->
256
+
257
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Metformin">
258
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
259
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
260
+ <hasAlternative rdf:resource="http://www.example.org/DrugInteraction.owl#Empagliflozin"/>
261
+ <hasInteraction rdf:resource="http://www.example.org/DrugInteraction.owl#Ciprofloxacin"/>
262
+ <hasSimilarity rdf:resource="http://www.example.org/DrugInteraction.owl#Glucophage"/>
263
+ <rdfs:label>Metformin</rdfs:label>
264
+ </rdf:Description>
265
+ <!-- -->
266
+ <!-- http://www.example.org/DrugInteraction.owl#Metronidazole -->
267
+
268
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Metronidazole">
269
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
270
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
271
+ <hasConflict rdf:resource="http://www.example.org/DrugInteraction.owl#Alcohol"/>
272
+ <rdfs:label>Metronidazole</rdfs:label>
273
+ </rdf:Description>
274
+ <!-- -->
275
+ <!-- http://www.example.org/DrugInteraction.owl#Naproxen -->
276
+
277
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Naproxen">
278
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
279
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
280
+ <rdfs:label>Naproxen</rdfs:label>
281
+ </rdf:Description>
282
+ <!-- -->
283
+ <!-- http://www.example.org/DrugInteraction.owl#Nifedipine -->
284
+
285
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Nifedipine">
286
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
287
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
288
+ <rdfs:label>Nifedipine</rdfs:label>
289
+ </rdf:Description>
290
+ <!-- -->
291
+ <!-- http://www.example.org/DrugInteraction.owl#Omeprazole -->
292
+
293
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Omeprazole">
294
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
295
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
296
+ <hasAlternative rdf:resource="http://www.example.org/DrugInteraction.owl#Pantoprazole"/>
297
+ <hasSimilarity rdf:resource="http://www.example.org/DrugInteraction.owl#Esomeprazole"/>
298
+ <rdfs:label>Omeprazole</rdfs:label>
299
+ </rdf:Description>
300
+ <!-- -->
301
+ <!-- http://www.example.org/DrugInteraction.owl#Pantoprazole -->
302
+
303
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Pantoprazole">
304
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
305
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
306
+ <rdfs:label>Pantoprazole</rdfs:label>
307
+ </rdf:Description>
308
+ <!-- -->
309
+ <!-- http://www.example.org/DrugInteraction.owl#Phenelzine -->
310
+
311
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Phenelzine">
312
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
313
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
314
+ <hasConflict rdf:resource="http://www.example.org/DrugInteraction.owl#tyramineFoods"/>
315
+ <rdfs:label>Phenelzine</rdfs:label>
316
+ </rdf:Description>
317
+ <!-- -->
318
+ <!-- http://www.example.org/DrugInteraction.owl#Rosuvastatin -->
319
+
320
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Rosuvastatin">
321
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
322
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
323
+ <rdfs:label>Rosuvastatin</rdfs:label>
324
+ </rdf:Description>
325
+ <!-- -->
326
+ <!-- http://www.example.org/DrugInteraction.owl#Sertraline -->
327
+
328
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Sertraline">
329
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
330
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
331
+ <hasSimilarity rdf:resource="http://www.example.org/DrugInteraction.owl#Fluoxetine"/>
332
+ <rdfs:label>Sertraline</rdfs:label>
333
+ </rdf:Description>
334
+ <!-- -->
335
+ <!-- http://www.example.org/DrugInteraction.owl#Simvastatin -->
336
+
337
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Simvastatin">
338
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
339
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
340
+ <hasAlternative rdf:resource="http://www.example.org/DrugInteraction.owl#Rosuvastatin"/>
341
+ <hasInteraction rdf:resource="http://www.example.org/DrugInteraction.owl#Erythromycin"/>
342
+ <rdfs:label>Simvastatin</rdfs:label>
343
+ </rdf:Description>
344
+ <!-- -->
345
+ <!-- http://www.example.org/DrugInteraction.owl#Spironolactone -->
346
+
347
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Spironolactone">
348
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
349
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
350
+ <rdfs:label>Spironolactone</rdfs:label>
351
+ </rdf:Description>
352
+ <!-- -->
353
+ <!-- http://www.example.org/DrugInteraction.owl#Theophylline -->
354
+
355
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Theophylline">
356
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
357
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
358
+ <hasConflict rdf:resource="http://www.example.org/DrugInteraction.owl#Caffeine"/>
359
+ <rdfs:label>Theophylline</rdfs:label>
360
+ </rdf:Description>
361
+ <!-- -->
362
+ <!-- http://www.example.org/DrugInteraction.owl#Warfarin -->
363
+
364
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#Warfarin">
365
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
366
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Drug"/>
367
+ <hasAlternative rdf:resource="http://www.example.org/DrugInteraction.owl#Apixaban"/>
368
+ <hasConflict rdf:resource="http://www.example.org/DrugInteraction.owl#greenLeafyVegetables"/>
369
+ <hasInteraction rdf:resource="http://www.example.org/DrugInteraction.owl#Aspirin"/>
370
+ <rdfs:label>Warfarin</rdfs:label>
371
+ </rdf:Description>
372
+ <!-- -->
373
+ <!-- http://www.example.org/DrugInteraction.owl#grapefruitJuice -->
374
+
375
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#grapefruitJuice">
376
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
377
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Consumable"/>
378
+ <rdfs:label>GrapefruitJuice</rdfs:label>
379
+ </rdf:Description>
380
+ <!-- -->
381
+ <!-- http://www.example.org/DrugInteraction.owl#greenLeafyVegetables -->
382
+
383
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#greenLeafyVegetables">
384
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
385
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Consumable"/>
386
+ <rdfs:label>GreenLeafyVegetables</rdfs:label>
387
+ </rdf:Description>
388
+ <!-- -->
389
+ <!-- http://www.example.org/DrugInteraction.owl#tyramineFoods -->
390
+
391
+ <rdf:Description rdf:about="http://www.example.org/DrugInteraction.owl#tyramineFoods">
392
+ <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
393
+ <rdf:type rdf:resource="http://www.example.org/DrugInteraction.owl#Consumable"/>
394
+ <rdfs:label>TyramineFoods</rdfs:label>
395
+ </rdf:Description>
396
+ <!-- -->
397
+ <!-- Generated by the OWL API (version 4.5.29.2024-05-13T12:11:03Z) https://github.com/owlcs/owlapi -->
398
+
399
+ </rdf:RDF>
requirements.txt ADDED
@@ -0,0 +1,7 @@
 
 
 
 
 
 
 
 
1
+ rdflib
2
+ langchain
3
+ python-dotenv
4
+ langchain-community
5
+ langchain-groq
6
+ langgraph
7
+ streamlit