As of 2020, there were approximately 50 million people worldwide with Alzheimer's disease.[9] It most often begins in people over 65 years of age, although up to 10% of cases are early-onset impacting those in their 30s to mid-60s.[17][4] It affects about 6% of people 65 years and older,[11] and women more often than men.[22] The disease is named after German psychiatrist and pathologist Alois Alzheimer, who first described it in 1906.[23] Alzheimer's financial burden on society is large, with an estimated global annual cost of US$1 trillion.[9] It is ranked as the seventh leading cause of death in the United States.[15]