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org/page/clinAnnLevels\uff0c \u5171\u5206\u4e3a 4 \u4e2a\u7b49\u7ea7\uff1a 1A\uff1a\u7531\u4e34\u5e8a\u836f\u7269\u57fa\u56e0\u7ec4\u5b66\u5b9e\u65bd\u8054\u76df\uff08CPIC\uff09\u6216\u9057\u4f20\u836f\u7406\u5b66\u6307\u5357\u8ba4\u53ef\uff0c \u6216\u5728\u9057\u4f20\u836f\u7406\u5b66\u7814\u7a76\u7f51\u7edc (PGRN) \u53ca\u5176\u5b83\u4e3b\u8981\u536b\u751f\u7cfb\u7edf \u4e2d\u5df2\u6709\u5e94\u7528\uff1b\n</details><details> <summary>\u51fa\u5904 [3] xx_ZL0123936.pdf</summary>\n \u5b89\u5fbd\u7701\u5408\u80a5\u5e02\u5e90\u9633\u533a\u961c\u9633\u5317\u8def\u4e0e\u5317\u57ce\u5927\u9053\u4ea4\u53e3\u521b\u667a\u5929\u5730 A6 \u53f7\u697c (400-801-9858) \u7b2c 34 \u9875/\u5171 36 \u9875 \u59d3\u540d\uff1a\u8096\u84d3 | \u62a5\u544a\u7f16\u53f7\uff1a502491 \u5b89\u62e9\u5eb7 \u00ae 3. 5\u9644\u5f55\u4e94\uff1a\u57fa\u56e0\u68c0\u6d4b\u62a5\u544a\u8bf4\u660e 01 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\u4e2a\u57fa\u56e0\u70ed\u70b9\u533a\u57df \u5171\u68c0\u51fa\u57fa\u56e0\u7a81\u53d8\u4f4d\u70b9\uff1a109 \u4e2a \u5177\u6709\u4e34\u5e8a\u610f\u4e49\u4f4d\u70b9\uff1a6\u4e2a \u514d\u75ab\u6cbb\u7597\u7597\u6548\u8bc4\u4f30 \u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08TMB\uff09 TMB-H \uff1a39. 44 Muts/Mb \u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\uff08MSI\uff09 MSS \u9519\u914d\u4fee\u590d\u57fa\u56e0\uff08MMR\uff09 \u81f4\u75c5/\u7591\u4f3c\u81f4\u75c5\u53d8\u5f02\uff1a1 \u4e2a \u5316\u7597\u7597\u6548\u53ca\u6bd2\u526f\u4f5c\u7528 \u5316\u7597\u836f\u7269\u7597\u6548\u53ca\u6bd2\u526f\u4f5c\u7528 \u6709\u6548\u6027\u8f83\u9ad8\u836f\u7269\uff1a4 \u4e2a \u6bd2\u526f\u4f5c\u7528\u8f83\u4f4e\u836f\u7269\uff1a6 \u4e2a \u9057\u4f20\u98ce\u9669\u8bc4\u4f30 \u9057\u4f20\u6613\u611f\u57fa\u56e0\u68c0\u6d4b\u7ed3\u679c \u81f4\u75c5/\u7591\u4f3c\u81f4\u75c5\u53d8\u5f02\uff1a0 \u4e2a \u5b89\u5fbd\u7701\u5408\u80a5\u5e02\u5e90\u9633\u533a\u961c\u9633\u5317\u8def\u4e0e\u5317\u57ce\u5927\u9053\u4ea4\u53e3\u521b\u667a\u5929\u5730 A6 \n</details><details> <summary>\u51fa\u5904 [2] xx_ZL0123936.pdf</summary>\n\u643a \u5e26\u8be5\u5206\u5b50\u7279\u5f81\u7684\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\uff08mCRPC\uff09 \u60a3\u8005\u53ef\u80fd\u5bf9 PARP \u6291\u5236\u5242\u53ca\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICIs\uff09 \u654f\u611f\u3002 \u7814\u7a76\u8868\u660e\uff0c \u643a\u5e26 CDK12 \u53cc\u7b49\u4f4d\u57fa\u56e0\u7f3a\u5931 mCRPC \u60a3\u8005\u53ef\u80fd\u5bf9\u514d\u75ab\u6cbb\u7597\u6709\u66f4\u9ad8\u7684\u53cd\u5e94\uff0c 4 \u4f8b CDK12 \u5931\u6d3b \u7a81\u53d8 mCRPC \u4e2d\uff0c 2 \u4f8b\u5bf9 PD-1 \u5355\u836f\u6cbb\u7597\u6709\u6548\uff08PMID\uff1a 29906450\uff09\u3002 \u57fa\u56e0 \u514d\u75ab\u6cbb\u7597 \u76f8\u5173\u6027 \u68c0\u6d4b\u7ed3\u679c \u53d8\u5f02\u89e3\u6790 \u68c0\u6d4b\u610f\u4e49 \u3010\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3011 ALK \u8d1f\u76f8\u5173 \u672a\u89c1\u76f8\u5173\u53d8\u5f02 \n</details><details> <summary>\u51fa\u5904 [3] xx_ZL0123936.pdf</summary>\n\u800c KRAS/TP53 \u53cc\u7a81\u53d8\u7684\u80ba\u817a\u764c\u53ef\u80fd\u6fc0\u53d1\u708e\u75c7\u578b\u514d\u75ab\u5fae\u73af \u5883\uff0c \u663e\u8457\u589e\u52a0\u80ba\u817a\u764c PD-L1 \u8868\u8fbe\u53ca PD-L1+/TIL+ \u53cc\u9633 \u6027\u6bd4\u4f8b\uff0c \u5177\u6709\u66f4\u5f3a\u7684\u514d\u75ab\u539f\u6027\uff0c \u53ef\u80fd\u662f\u6297 PD-1 \u514d\u75ab\u6cbb \u7597\u7684\u6f5c\u5728\u9884\u6d4b\u6807\u5fd7\u7269\u3002 TP53 \u6b63\u76f8\u5173 p. R213X; p. R248Q \u53ef\u80fd\u7684\u529f\u80fd\u5931 \u6d3b\u6027\u81f4\u764c\u53d8 \u5f02; \u53ef\u80fd\u7684\u529f\u80fd\u5931 \u6d3b\u6027\u81f4\u764c\u53d8\u5f02 \u57fa\u56e0 \u514d\u75ab\u6cbb\u7597 \u76f8\u5173\u6027 \u68c0\u6d4b\u7ed3\u679c \u53d8\u5f02\u89e3\u6790 \u68c0\u6d4b\u610f\u4e49 \u5b89\u5fbd\u7701\u5408\u80a5\u5e02\u5e90\u9633\u533a\u961c\u9633\u5317\u8def\u4e0e\u5317\u57ce\u5927\u9053\u4ea4\u53e3\u521b\u667a\u5929\u5730 A6 \u53f7\u697c (400-801-9858) \u7b2c 15 \u9875/\u5171 36 \u9875 \n</details>"], ["\u654f\u611f\u836f\u7269\u662f\u4ec0\u4e48\uff1f", 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\u6279\u51c6\u53ca\u6307\u5357\u63a8\u8350\u7528\u4e8e\u672c\u764c\u79cd\u7684\u9776\u5411\u836f\u7269\uff1b 2. \u82e5\u6837\u672c\u540c\u65f6\u68c0\u51fa\u654f\u611f\u7a81\u53d8\u548c\u8010\u836f\u7a81\u53d8\uff0c\u7528\u836f\u65f6\u8bf7\u7efc\u5408\u8003\u8651\uff0c\u7528\u836f\u5faa\u8bc1\u8be6\u89c1 2. 2\u8282\u3002 \u7528\u836f\u9700\u9075\u533b\u5631\uff0c\u8c28\u614e\u7528\u836f\u3002 1. 3. 2 \u514d\u75ab\u7528\u836f\u63d0\u793a \u514d\u75ab\u6307\u6807 \u68c0\u6d4b\u7ed3\u679c \u7ed3\u679c\u89e3\u8bfb TMB TMB-H \u7528\u836f\u8be6\u89c1 2. 3. 1\u8282 MSI MSS \u7528\u836f\u8be6\u89c1 2. 3. 2\u8282 \u8865\u5145\u8bf4\u660e\uff1a 1.\n</details>"], ["\u4e34\u5e8a\u5e38\u89c4\u9776\u5411\u836f\u7269\u57fa\u56e0\u68c0\u6d4b\u7ed3\u679c\u662f\u4ec0\u4e48\uff1f", 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\u6211\u4eec\u575a\u4fe1\uff0c\u6562\u4e8e\u76f4\u9762\u80bf\u7624\u7684\u60a8\u4e0d\u4ec5\u662f\u751f\u547d\u7684\u52c7\u58eb\uff0c\u66f4\u662f\u751f\u6d3b\u7684\u5f3a\u8005\uff01 \u5728\u6218\u80dc\u80bf\u7624\u7684\u9053\u8def\u4e0a\uff0c\u6211\u4eec\u4e3a\u60a8\u79d1\u5b66\u62a4\u822a\uff0c\u4e0e\u60a8 \u4e00\u8d77\u6218\u6597\uff01\n</details><details> <summary>\u51fa\u5904 [2] xx_ZL0123936.pdf</summary>\n1 \u9001\u68c0\u4fe1\u606f 1 1. 2 \u68c0\u6d4b\u9879\u76ee\u53ca\u7ed3\u679c 1 1. 3 \u4e34\u5e8a\u7528\u836f\u63d0\u793a 2 1. 3. 1 \u9776\u5411\u7528\u836f\u63d0\u793a 2 1. 3. 2 \u514d\u75ab\u7528\u836f\u63d0\u793a 2 1. 3. 3 \u5316\u7597\u7528\u836f\u63d0\u793a 2 02 \u68c0\u6d4b\u7ed3\u679c\u8be6\u7ec6\u89e3\u8bfb 2. 1 \u4e34\u5e8a\u5e38\u89c4\u9776\u5411\u836f\u7269\u57fa\u56e0\u68c0\u6d4b\u7ed3\u679c 3 2. 2 \u9776\u5411\u57fa\u56e0\u7ed3\u679c\u89e3\u8bfb 4 2. 3 \u514d\u75ab\u6cbb\u7597\u76f8\u5173\u68c0\u6d4b\u7ed3\u679c\u89e3\u8bfb 9 2. 3. 1 \u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08TMB\uff09 9 2. 3. 2 \u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\uff08MSI\uff09 11 2. 3. 3 DNA \u9519\u914d\u4fee\u590d\u57fa\u56e0\uff08MMR\uff09 12 2. 3.\n</details><details> <summary>\u51fa\u5904 [3] xx_ZL0123936.pdf</summary>\n\u7528\u836f\u9700\u9075\u533b\u5631\uff0c\u8c28\u614e\u7528\u836f\u3002 1. 3. 3 \u5316\u7597\u7528\u836f\u63d0\u793a \u5177\u4f53\u5206\u6790\u7ed3\u679c\u89c1 2. 4\u8282\u3002 \u5b89\u5fbd\u7701\u5408\u80a5\u5e02\u5e90\u9633\u533a\u961c\u9633\u5317\u8def\u4e0e\u5317\u57ce\u5927\u9053\u4ea4\u53e3\u521b\u667a\u5929\u5730 A6 \u53f7\u697c (400-801-9858) \u7b2c 2 \u9875/\u5171 36 \u9875 \u59d3\u540d\uff1a\u8096\u84d3 | \u62a5\u544a\u7f16\u53f7\uff1a502491 \u5b89\u62e9\u5eb7 \u00ae 02\u68c0\u6d4b\u7ed3\u679c\u8be6\u7ec6\u89e3\u8bfb Detailed analysis of test results 2. 1\u4e34\u5e8a\u5e38\u89c4\u9776\u5411\u836f\u7269\u57fa\u56e0\u68c0\u6d4b\u7ed3\u679c \u672c\u5217\u8868\u5c55\u793a\u6307\u5357\u53ca\u5171\u8bc6\u63a8\u8350\u68c0\u6d4b\u5b9e\u4f53\u7624\u76f8\u5173\u70ed\u70b9\u57fa\u56e0\u7684\u7a81\u53d8\u60c5\u51b5\uff1a AKT1 \u70b9\u7a81\u53d8 \u9634\u6027 - - ALK \n</details><details> <summary>\u51fa\u5904 [4] xx_ZL0123936.pdf</summary>\n3. 4 \u6f5c\u5728\u5f71\u54cd\u514d\u75ab\u6cbb\u7597\u7597\u6548\u7684\u57fa\u56e0\u68c0\u6d4b\u7ed3\u679c \u5b89\u62e9\u5eb7\u2013NGS \u5b9e\u4f53\u7624 658 \u57fa\u56e0 TMB \u68c0\u6d4b\u5305\u542b\u4e0e\u514d\u75ab\u6cbb\u7597\u7597\u6548\u76f8\u5173\u57fa\u56e0\uff1a\u6b63\u76f8\u5173\u3001\u8d1f\u76f8\u5173\u4ee5\u53ca\u8d85\u8fdb\u5c55\u76f8\u5173\u57fa\u56e0\uff0c \u8fd9\u4e9b\u57fa\u56e0 \u6765\u6e90\u4e8e\u90e8\u5206\u764c\u79cd\u7684\u4e34\u5e8a\u524d\u6216\u521d\u671f\u7814\u7a76\u7ed3\u679c\uff0c \u68c0\u6d4b\u7ed3\u679c\u4ec5\u4f9b\u4e34\u5e8a\u53c2\u8003\u3002 \u3010\u5b9e\u4f53\u7624\u3011 MLH1 \u6b63\u76f8\u5173 \u672a\u89c1\u76f8\u5173\u53d8\u5f02 - - DNA \u9519\u914d\u4fee\u590d\u57fa\u56e0\uff08MMR\uff09\u53d1\u751f\u81f4\u75c5\u6216\u7591\u4f3c\u81f4\u75c5\u53d8\u5f02 \u65f6\uff0c\u53ef\u80fd\u4f1a\u5bfc\u81f4 MSI-H \u6216 dMMR\uff0c\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236 \u5242\uff08ICIs\uff09\u7597\u6548\u5448\u6b63\u76f8\u5173\u3002\n</details>"], ["\u836f\u7269\u8be2\u8bc1\u662f\u6307\u4ec0\u4e48\uff1f", "<p>\u836f\u7269\u8be2\u8bc1\u662f\u6307\u9488\u5bf9\u53d7\u68c0\u8005\u80bf\u7624\u7c7b\u578b\uff0c\u6240\u5217\u751f\u7269\u6807\u5fd7\u7269\u4e0e\u836f\u7269\u54cd\u5e94\u5173\u7cfb\u7684\u8bc1\u636e\u6765\u6e90\u3002\u672c\u62a5\u544a\u6240\u91c7\u7528\u836f\u7269\u8be2\u8bc1\u7b49\u7ea7\u662f\u5728\u80bf\u7624\u7cbe\u51c6\u7528\u836f\u6570\u636e\u5e93 OncoKB \u836f\u7269\u8be2\u8bc1\u7b49\u7ea7\u7684\u57fa\u7840\u4e0a\uff0c\u878d\u5165 NMPA \u836f\u54c1\u8bf4\u660e\u4e66\u53ca\u56fd\u5185\u6307\u5357\u5171\u8bc6\u53ca\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u636e\uff0c\u5171\u5212\u5206\u4e3a 6 \u4e2a\u7b49\u7ea7\uff0c\u5305\u62ec\u672c\u764c\u79cd\u7528\u836f\u63d0\u793a\u654f\u611f\u5305\u62ec 1 \u7ea7\u548c 2 \u7ea7\u8be2\u8bc1\u836f\u7269\uff0c\u53ef\u80fd\u654f\u611f\u5305\u62ec 3A \u7ea7\u548c 4 \u7ea7\u8be2\u8bc1\u836f\u7269\uff0c\u6f5c\u5728\u8010\u836f\u5305\u62ec R1 \u7ea7\u548c R2 \u7ea7\u8be2\u8bc1\u836f\u7269\u3002</p>\n<details> <summary>\u51fa\u5904 [1] xx_ZL0123936.pdf</summary>\n\u7ea7) \u53ef\u80fd\u654f\u611f (3B \u7ea7) \u6ce8\uff1a 1. \u836f\u7269\u8be2\u8bc1\u662f\u6307\uff0c\u9488\u5bf9\u53d7\u68c0\u8005\u80bf\u7624\u7c7b\u578b\uff0c\u6240\u5217\u751f\u7269\u6807\u5fd7\u7269\u4e0e\u836f\u7269\u54cd\u5e94\u5173\u7cfb\u7684\u8bc1\u636e\u6765\u6e90\u3002 \u672c\u62a5\u544a\u6240\u91c7\u7528\u836f\u7269\u8be2\u8bc1\u7b49\u7ea7\u662f\u5728\u80bf\u7624 \u7cbe\u51c6\u7528\u836f\u6570\u636e\u5e93 OncoKB \u836f\u7269\u8be2\u8bc1\u7b49\u7ea7\u7684\u57fa\u7840\u4e0a\uff0c \u878d\u5165 NMPA \u836f\u54c1\u8bf4\u660e\u4e66\u53ca\u56fd\u5185\u6307\u5357\u5171\u8bc6\u53ca\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u636e\uff0c \u5171\u5212\u5206\u4e3a 6 \u4e2a \u7b49\u7ea7\u5982\u4e0b\uff0c \u672c\u764c\u79cd\u7528\u836f\u63d0\u793a\u654f\u611f\u5305\u62ec 1 \u7ea7\u548c 2 \u7ea7\u8be2\u8bc1\u836f\u7269\uff0c \u53ef\u80fd\u654f\u611f\u5305\u62ec 3A \u7ea7\u548c 4 \u7ea7\u8be2\u8bc1\u836f\u7269\uff0c \u6f5c\u5728\u8010\u836f\u5305\u62ec R1 \u7ea7\u548c R2 \u7ea7\u8be2\u8bc1\u836f\u7269\uff0c\n</details>"], ["\u4ec0\u4e48\u662f\u7a81\u53d8\u4e30\u5ea6\uff1f", "<p>\u7a81\u53d8\u4e30\u5ea6\u662f\u6307\u67d0\u4e2a\u57fa\u56e0\u4f4d\u70b9\u7a81\u53d8\u7b49\u4f4d\u57fa\u56e0\u5360\u6240\u6709\u7b49\u4f4d\u57fa\u56e0\u7684\u6bd4\u4f8b\uff0c\u5373\u7b49\u4e8e\u7a81\u53d8\u578b/\uff08\u7a81\u53d8\u578b + \u91ce\u751f\u578b\uff09\u3002\u5b83\u4e3b\u8981\u7528\u4e8e\u70b9\u7a81\u53d8\u6216\u5c0f\u7247\u6bb5\u63d2\u5165\u7f3a\u5931\u60c5\u51b5\u7684\u8bc4\u4f30\u3002\u5728\u80bf\u7624\u7cbe\u51c6\u7528\u836f\u6570\u636e\u5e93 OncoKB \u4e2d\uff0c\u7a81\u53d8\u4e30\u5ea6\u88ab\u5212\u5206\u4e3a R1\u3001R2\u3001R3 \u4e09\u4e2a\u7b49\u7ea7\uff0c\u7528\u4e8e\u9884\u6d4b\u540c\u79cd\u836f\u7269\u7684\u8010\u836f\u6027\u3002</p>\n<details> <summary>\u51fa\u5904 [1] xx_ZL0123936.pdf</summary>\n R2 \u7ea7\uff1a\u672c\u764c\u79cd\u4e2d\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u63d0\u793a\u8be5\u751f\u7269\u6807\u5fd7\u7269\u53ef\u80fd\u5bfc\u81f4\u8010\u836f\uff1b \u6216\u5176\u4ed6\u764c\u79cd\u7684\u836f\u54c1\u8bf4\u660e\u4e66\u6216\u6307\u5357\u6307\u51fa\u8be5\u751f\u7269\u6807\u5fd7\u7269\u9884\u6d4b\u540c\u79cd\u836f \u7269\u7684\u8010\u836f\u6027\u3002 2. \u7a81\u53d8\u4e30\u5ea6\uff1a\u67d0\u4e2a\u57fa\u56e0\u4f4d\u70b9\u7684\u7a81\u53d8\u7b49\u4f4d\u57fa\u56e0\u5360\u6240\u6709\u7b49\u4f4d\u57fa\u56e0\u7684\u6bd4\u4f8b\uff0c\u5373\u7b49\u4e8e\u7a81\u53d8\u578b/\uff08\u7a81\u53d8\u578b + \u91ce\u751f\u578b\uff09\uff0c\u4e00\u822c\u9488\u5bf9\u70b9\u7a81\u53d8\u6216 \u5c0f\u7247\u6bb5\u63d2\u5165\u7f3a\u5931\u60c5\u51b5\uff1b \u62f7\u8d1d\u6570\uff1a\u53d7\u68c0\u8005\u57fa\u56e0\u62f7\u8d1d\u6570\u53d8\u5316\u60c5\u51b5\uff0c\u4ee5 2 \u4e3a\u6b63\u5e38\u503c\u3002 \u7a81\u53d8\u4e30\u5ea6\u548c\u62f7\u8d1d\u6570\u53d7\u80bf\u7624\u7ec6\u80de\u542b\u91cf\u548c\u53d6\u6750\u7b49\u56e0 \u7d20\u7684\u5f71\u54cd\u3002 3. \u672c\u62a5\u544a\u68c0\u6d4b\u7ed3\u679c\u53ca\u7528\u836f\u63a8\u8350\u4ec5\u4f9b\u4e34\u5e8a\u53c2\u8003\uff0c\u5177\u4f53\u9700\u4e34\u5e8a\u533b\u751f\u7ed3\u5408\u60a3\u8005\u5b9e\u9645\u60c5\u51b5\u786e\u5b9a\u5408\u7406\u7684\u6cbb\u7597\u65b9\u6848\u3002\n</details><details> <summary>\u51fa\u5904 [2] xx_ZL0123936.pdf</summary>\n 3. \u7ed3\u679c\u63d0\u793a\uff1a\u82e5\u68c0\u6d4b\u7ed3\u679c\u4e3a MSI-H\uff0c\u63d0\u793a\u4ece\u514d\u75ab\u6cbb\u7597\u4e2d\u83b7\u76ca\u53ef\u80fd\u6027\u8f83\u9ad8\uff1b \u82e5\u68c0\u6d4b\u7ed3\u679c\u4e3a MSS\uff0c\u63d0\u793a\u4ece\u514d\u75ab\u6cbb\u7597\u4e2d\u83b7\u76ca\u53ef\u80fd\u6027 \u8f83\u4f4e\uff0c\u9700\u7ed3\u5408\u5176\u4ed6\u6307\u6807\u7efc\u5408\u8bc4\u4f30\u7528\u836f\u3002 \u6807\u5fd7\u7269\u89e3\u6790\uff1a 1. \u59d3\u540d\uff1a\u8096\u84d3 | \u62a5\u544a\u7f16\u53f7\uff1a502491 \u5b89\u62e9\u5eb7 \u00ae 2. 3. 3 DNA \u9519\u914d\u4fee\u590d\u57fa\u56e0\uff08MMR\uff09 - - DNA \u9519\u914d\u4fee\u590d\u57fa\u56e0\uff08MMR\uff09- - \u57fa\u56e0 \u5916\u663e\u5b50 \u6838\u82f7\u9178\u53d8\u5f02 \u6c28\u57fa\u9178\u53d8\u5f02 \u7a81\u53d8\u4e30\u5ea6 \u4e34\u5e8a\u610f\u4e49 \u7a81\u53d8\u6765\u6e90 MLH1 - - - - - - - - - - - - MSH2 - - - \n</details><details> <summary>\u51fa\u5904 [3] xx_ZL0123936.pdf</summary>\n636G>A p. A212A 1. 70% COSV58998843 \u201c.\u201d\u8868\u793a\u8be5\u7a81\u53d8\u672a\u6709 cosmic \u6570\u636e\u5e93\u8bb0\u5f55 - - \u57fa\u56e0\u62f7\u8d1d\u6570\u5206\u6790\u7ed3\u679c - - \u57fa\u56e0 \u67d3\u8272\u4f53\u4f4d\u7f6e \u62f7\u8d1d\u6570 JUN chr1 9. 03 - - \u57fa\u56e0\u91cd\u6392\u5206\u6790\u7ed3\u679c - - 5 \u2032 \u7aef\u7a81\u53d8 3 \u2032 \u7aef\u7a81\u53d8 \u53d8\u5f02 \u57fa\u56e0 \u8f6c\u5f55\u672c \u5916\u663e\u5b50 \u57fa\u56e0 \u8f6c\u5f55\u672c \u5916\u663e\u5b50 \u7a81\u53d8\u4e30\u5ea6 - - - - - - - - - - - - - - - - \u5b89\u5fbd\u7701\u5408\u80a5\u5e02\u5e90\u9633\u533a\u961c\u9633\u5317\u8def\u4e0e\u5317\u57ce\u5927\u9053\u4ea4\u53e3\u521b\u667a\u5929\u5730 A6 \u53f7\u697c (400-801-9858) \u7b2c 25 \u9875/\u5171 36 \u9875 \u59d3\u540d\uff1a\u8096\u84d3 | \u62a5\u544a\u7f16\u53f7\uff1a502491 \u5b89\u62e9\u5eb7 \u00ae - - \u80da\u7cfb\u81f4\u75c5\u6027\u53d8\u5f02\u5206\u6790\u7ed3\u679c - - \u57fa\u56e0 \u8f6c\u5f55\u672c \u5916\u663e\u5b50 \u6838\u82f7\u9178\u53d8\u5f02 \u6c28\u57fa\u9178\u53d8\u5f02 \u7a81\u53d8\u4e30\u5ea6 \u4e34\u5e8a\u610f\u4e49 - - - - - - - - - - - - - - - - \u672a\u68c0\u6d4b\u5230\u53d8\u5f02\u7684\u70ed\u70b9\u57fa\u56e0 - - CDKN2B PDGFRA SMAD4 HRAS ATM EGFR RET CTNNB1 AKT1 MAP2K1 EZH2 RAD51B EPCAM FH BRIP1 TSC2 ROS1 TSC1 RAD51D BAP1 \n</details>"], ["\u8096\u84d3\u7684\u68c0\u6d4b\u7ed3\u679c\u5982\u4f55\uff1f", "<p>\u6839\u636e\u63d0\u4f9b\u7684\u4fe1\u606f\uff0c\u6211\u4eec\u65e0\u6cd5\u5f97\u51fa\u8096\u84d3\u7684\u68c0\u6d4b\u7ed3\u679c\u3002\u56e0\u4e3a\u8be5\u95ee\u9898\u6ca1\u6709\u63d0\u4f9b\u8db3\u591f\u7684\u76f8\u5173\u4fe1\u606f\uff0c\u6211\u4eec\u65e0\u6cd5\u786e\u5b9a\u62a5\u544a\u7f16\u53f7\u4e3a502491\u7684\u5b89\u62e9\u5eb7\u00ae\u7684\u68c0\u6d4b\u6982\u89c8\u4e2d\u662f\u5426\u6709\u5173\u4e8e\u8096\u84d3\u7684\u68c0\u6d4b\u7ed3\u679c\u7684\u63cf\u8ff0\u3002</p>\n<details> <summary>\u51fa\u5904 [1] xx_ZL0123936.pdf</summary>\n4 \u5316\u7597\u836f\u7269\u68c0\u6d4b\u7ed3\u679c\u53ca\u4e34\u5e8a\u7528\u836f\u63d0\u793a 17 2. 5 \u9057\u4f20\u6613\u611f\u57fa\u56e0\u68c0\u6d4b\u7ed3\u679c 21 03 \u9644\u5f55 3. 1 \u9644\u5f55\u4e00\uff1a\u57fa\u56e0\u53d8\u5f02\u6c47\u603b 22 3. 2 \u9644\u5f55\u4e8c\uff1a\u6837\u672c\u8d28\u63a7 27 3. 3 \u9644\u5f55\u4e09\uff1a\u57fa\u56e0\u5217\u8868 28 3. 4 \u9644\u5f55\u56db\uff1a\u53c2\u8003\u6587\u732e 33 3. 5 \u9644\u5f55\u4e94\uff1a\u57fa\u56e0\u68c0\u6d4b\u62a5\u544a\u8bf4\u660e 35 \u59d3\u540d\uff1a\u8096\u84d3 | \u62a5\u544a\u7f16\u53f7\uff1a502491 \u5b89\u62e9\u5eb7 \u00ae 01\u68c0\u6d4b\u6982\u89c8 Test Overview 1. 1\u9001\u68c0\u4fe1\u606f \u59d3\u540d\uff1a\u8096\u84d3 \u6027 \u522b\uff1a\u5973 \u8054\u7cfb\u65b9\u5f0f\uff1a \u57fa\u672c\u4fe1\u606f \u5e74\u9f84\uff1a60 \u5c81 \u6837\u672c\u7f16\u53f7\uff1aZL0123936 \u9001\u68c0\u5355\u4f4d\uff1a \n</details><details> <summary>\u51fa\u5904 [2] xx_ZL0123936.pdf</summary>\n\u5176\u4e2d\uff0c\u7597\u6548\u9884\u6d4b\u6216\u6bd2\u526f\u98ce \u9669\u9884\u6d4b\u4e2d\u6807\u201c- - \u201d\u8868\u793a\u76ee\u524d\u7814\u7a76\u7ed3\u679c\u8f83\u5c11\u6216\u8be2\u8bc1\u7ea7\u522b\u8f83\u4f4e\uff0c\u4e0d\u8db3\u4ee5\u63d0\u4f9b\u7528\u836f\u5efa\u8bae\uff1b 3. \u5bf9\u4e8e\u6709\u6548\u6027\u6216\u6bd2\u526f\u4f5c\u7528\u5bf9\u5e94\u591a\u4e2a\u57fa\u56e0\u591a\u6001\u6027\u4f4d\u70b9\u7684\u836f\u7269\uff0c\u4f1a\u6839\u636e\u8bc1\u636e\u652f\u6301\u7b49\u7ea7\u7b49\u4fe1\u606f\u8fdb\u884c\u7efc\u5408\u89e3\u8bfb\uff1b 4. \u6b64\u5904\u68c0\u6d4b\u7ed3\u679c\u4e0d\u5177\u6709\u4e34\u5e8a\u533b\u5631\u6027\u8d28\uff0c\u4ec5\u4f9b\u4e34\u5e8a\u533b\u5e08\u53c2\u8003\uff0c\u4e0d\u4f5c\u4e3a\u76f4\u63a5\u7528\u836f\u4f9d\u636e\u3002 \u5b89\u5fbd\u7701\u5408\u80a5\u5e02\u5e90\u9633\u533a\u961c\u9633\u5317\u8def\u4e0e\u5317\u57ce\u5927\u9053\u4ea4\u53e3\u521b\u667a\u5929\u5730 A6 \u53f7\u697c (400-801-9858) \u7b2c 17 \u9875/\u5171 36 \u9875 \u59d3\u540d\uff1a\u8096\u84d3 | \u62a5\u544a\u7f16\u53f7\uff1a502491 \u5b89\u62e9\u5eb7 \u00ae \u3010\u5316\u7597\u7528\u836f\u65b9\u6848\u89e3\u6790\u3011 \u836f\u7269\uff1a5-\u6c1f\u5c3f\u5627\u5576 \u57fa\u56e0 \n</details><details> <summary>\u51fa\u5904 [3] xx_ZL0123936.pdf</summary>\nGA \u8f83\u77ed\u7684\u603b\u751f\u5b58\u65f6\u95f4 - - 3 TYMS rs151264360 ID \u6709\u5229\u4e8e\u5ef6\u957f\u65e0\u8fdb\u5c55\u751f\u5b58\u671f - - 3 \u836f\u7269\uff1a\u591a\u897f\u4ed6\u8d5b \u5b89\u5fbd\u7701\u5408\u80a5\u5e02\u5e90\u9633\u533a\u961c\u9633\u5317\u8def\u4e0e\u5317\u57ce\u5927\u9053\u4ea4\u53e3\u521b\u667a\u5929\u5730 A6 \u53f7\u697c (400-801-9858) \u7b2c 18 \u9875/\u5171 36 \u9875 \u59d3\u540d\uff1a\u8096\u84d3 | \u62a5\u544a\u7f16\u53f7\uff1a502491 \u5b89\u62e9\u5eb7 \u00ae \u57fa\u56e0 \u4f4d\u70b9 \u68c0\u6d4b\u7ed3\u679c \u7597\u6548 \u6bd2\u526f\u4f5c\u7528 \u8bc1\u636e\u7b49\u7ea7 CASP7 rs2227310 CG \u589e\u52a0\u603b\u4f53\u751f\u5b58\u65f6\u95f4 - - 3 CASP7 rs12415607 CA \u589e\u52a0\u603b\u4f53\u751f\u5b58\u65f6\u95f4 - - \n</details><details> <summary>\u51fa\u5904 [4] xx_ZL0123936.pdf</summary>\n\u57fa\u56e0 \u4f4d\u70b9 \u68c0\u6d4b\u7ed3\u679c \u7597\u6548 \u6bd2\u526f\u4f5c\u7528 \u8bc1\u636e\u7b49\u7ea7 GSTP1 rs1695 AA \u836f\u7269\u53cd\u5e94\u589e\u52a0 \u6bd2\u6027\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\u4e0b\u964d 2A \u5b89\u5fbd\u7701\u5408\u80a5\u5e02\u5e90\u9633\u533a\u961c\u9633\u5317\u8def\u4e0e\u5317\u57ce\u5927\u9053\u4ea4\u53e3\u521b\u667a\u5929\u5730 A6 \u53f7\u697c (400-801-9858) \u7b2c 19 \u9875/\u5171 36 \u9875 \u59d3\u540d\uff1a\u8096\u84d3 | \u62a5\u544a\u7f16\u53f7\uff1a502491 \u5b89\u62e9\u5eb7 \u00ae \u836f\u7269\uff1a\u957f\u6625\u65b0\u78b1 \u57fa\u56e0 \u4f4d\u70b9 \u68c0\u6d4b\u7ed3\u679c \u7597\u6548 \u6bd2\u526f\u4f5c\u7528 \u8bc1\u636e\u7b49\u7ea7 ABCB1 rs1045642 AG \u65e0\u4e8b\u4ef6\u751f\u5b58\u7387\u53ef\u80fd\u964d\u4f4e - - 3 ABCB1 rs2032582 AA \u603b\u4f53\u751f\u5b58\u671f\u589e\u52a0 \n</details><details> <summary>\u51fa\u5904 [5] xx_ZL0123936.pdf</summary>\n\u53d8\u5f02 \u57fa\u56e0 \u8f6c\u5f55\u672c \u5916\u663e\u5b50 \u57fa\u56e0 \u8f6c\u5f55\u672c \u5916\u663e\u5b50 \u7a81\u53d8\u4e30\u5ea6 - - - - - - - - - - - - - - - - \u5b89\u5fbd\u7701\u5408\u80a5\u5e02\u5e90\u9633\u533a\u961c\u9633\u5317\u8def\u4e0e\u5317\u57ce\u5927\u9053\u4ea4\u53e3\u521b\u667a\u5929\u5730 A6 \u53f7\u697c (400-801-9858) \u7b2c 25 \u9875/\u5171 36 \u9875 \u59d3\u540d\uff1a\u8096\u84d3 | \u62a5\u544a\u7f16\u53f7\uff1a502491 \u5b89\u62e9\u5eb7 \u00ae - - \u80da\u7cfb\u81f4\u75c5\u6027\u53d8\u5f02\u5206\u6790\u7ed3\u679c - - \u57fa\u56e0 \u8f6c\u5f55\u672c \u5916\u663e\u5b50 \u6838\u82f7\u9178\u53d8\u5f02 \u6c28\u57fa\u9178\u53d8\u5f02 \u7a81\u53d8\u4e30\u5ea6 \u4e34\u5e8a\u610f\u4e49 - - - - - - - - - - - - - - - - \u672a\u68c0\u6d4b\u5230\u53d8\u5f02\u7684\u70ed\u70b9\u57fa\u56e0 - \n</details>"], ["\u5e15\u5c3c\u5355\u6297\u662f\u4ec0\u4e48\uff1f", "<p>\u5e15\u5c3c\u5355\u6297\uff08Panitumumab\uff0cVectibix\uff09\u662f\u4e00\u79cd\u91cd\u7ec4\u7684\u4eba\u6e90\u5316 IgG2 \u5355\u6297\uff0c\u7279\u5f02\u6027\u7ed3\u5408\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u3002\u5b83\u88ab\u7528\u4e8e\u6cbb\u7597\u67d0\u4e9b\u7c7b\u578b\u7684\u7ed3\u80a0\u764c\uff0c\u5305\u62ec\u5de6\u534a\u7ed3\u80a0\u764c\u548c\u53f3\u534a\u7ed3\u80a0\u764c\u3002\u5e15\u5c3c\u5355\u6297\u901a\u8fc7\u7ade\u4e89\u6027\u5730\u6291\u5236\u914d\u4f53\u4e0eEGFR\u7ed3\u5408\uff0c\u963b\u65ad\u914d\u4f53\u8bf1\u5bfc\u7684\u53d7\u4f53\u81ea\u78f7\u9178\u5316\u548c\u53d7\u4f53\u76f8\u5173\u6fc0\u9176\u7684\u6fc0\u6d3b\uff0c\u4ece\u800c\u6291\u5236\u7ec6\u80de\u751f\u957f\uff0c\u8bf1\u5bfc\u7ec6\u80de\u51cb\u4ea1\uff0c\u964d\u4f4e\u4fc3\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u548c\u8840\u7ba1\u751f\u957f\u56e0\u5b50\u7684\u4ea7\u751f\u3002\u5e15\u5c3c\u5355\u6297\u5df2\u7ecf\u83b7\u5f97\u4e86 FDA \u7684\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u5148\u524d\u63a5\u53d7\u6807\u51c6\u5316\u7597\u540e\u8fdb\u5c55\u7684 RAS\u91ce\u751f\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff0c\u4ee5\u53ca\u8054\u5408\u5316\u7597\u7528\u4e8e RAS\u91ce\u751f\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3002</p>\n<details> <summary>\u51fa\u5904 [1] xx_ZL0123936.pdf</summary>\n1 \u9875/\u5171 36 \u9875 8\u59d3\u540d\uff1a\u8096\u84d3 | \u62a5\u544a\u7f16\u53f7\uff1a502491 \u5b89\u62e9\u5eb7 \u00ae 1. 3\u4e34\u5e8a\u7528\u836f\u63d0\u793a 1. 3. 1 \u9776\u5411\u7528\u836f\u63d0\u793a \u654f\u611f\u836f\u7269 \u3010\u672c\u764c\u79cd\u83b7\u6279/\u6307\u5357\u63a8\u8350\u3011 \u5e15\u5c3c\u5355\u6297\u3001\u8d1d\u4f10\u73e0\u5355\u6297\u3001\u897f\u59a5\u6614\u5355\u6297 \u53ef\u80fd\u654f\u611f\u836f\u7269 \u3010\u5176\u4ed6\u764c\u79cd\u83b7\u6279/\u4e34\u5e8a\u8bd5\u9a8c\u3011 JW55\u3001AZD1775\u3001APR-246\u3001Ganetespib\u3001G007-LK\u3001\u897f\u7f57\u83ab\u53f8 \u8010\u836f\u836f\u7269 \u3010\u672c\u764c\u79cd\u83b7\u6279\u53ca\u6307\u5357\u6536\u5f55\u8bc1\u636e\u3011 \u65e0 \u53ef\u80fd\u8010\u836f\u836f\u7269 \u3010\u4e34\u5e8a\u7814\u7a76/\u5176\u4ed6\u764c\u79cd\u8010\u836f\u63d0\u793a\u3011 \u65e0 \u8865\u5145\u8bf4\u660e\uff1a 1.\n</details><details> <summary>\u51fa\u5904 [2] xx_ZL0123936.pdf</summary>\nR1242H (\u7a81\u53d8\u4e30\u5ea6: 1. 80%) \u65e0 \u65e0 \u65e0 \u65e0 JUN: \u62f7\u8d1d\u6570\u6269\u589e (\u62f7\u8d1d\u6570: 9. 03) \u65e0 \u65e0 \u65e0 \u65e0 TP53: NM_000546: exon7: c. 743G>A: p. R248Q (\u7a81\u53d8\u4e30\u5ea6: 50. 70%) \u65e0 Ganetespib (4 \u7ea7); AZD1775 (4 \u7ea7) \u65e0 APR-246 (3B \u7ea7) KRAS \u91ce\u751f\u578b; NRAS \u91ce\u751f\u578b; BRAF \u91ce\u751f\u578b \u5e15\u5c3c\u5355\u6297 (1 \u7ea7); \u897f\u59a5\u6614\u5355\u6297 (1 \u7ea7); \u8d1d\u4f10\u73e0\u5355\u6297 (2 \u7ea7) \u65e0 \u65e0 \u65e0 \u57fa\u56e0\u53d8\u5f02 \n</details><details> <summary>\u51fa\u5904 [3] xx_ZL0123936.pdf</summary>\n \u5206\u6790\u6570\u636e\u663e\u793a\uff1a\u5728\u5de6\u534a\u7ed3\u80a0\u764c\uff0c\u897f\u59a5\u6614\u5355\u6297\u5728\u5ba2\u89c2\u6709\u6548\u7387\u548c\u603b\u751f\u5b58\u4e0a\u5747\u4f18\u4e8e\u8d1d\u4f10\u73e0\u5355\u6297\uff1b \u800c\u5728\u53f3\u534a\u7ed3\u80a0 \u764c\uff0c\u897f\u59a5\u6614\u5355\u6297\u867d\u7136\u5728\u5ba2\u89c2\u6709\u6548\u7387\u4e0a\u53ef\u80fd\u5b58\u5728\u4e00\u5b9a\u4f18\u52bf\uff0c\u4f46\u5728\u603b\u751f\u5b58\u671f\u4e0a\u4e0d\u5982\u8d1d\u4f10\u73e0\u5355\u6297\uff0c\u53f3\u534a\u7ed3\u80a0\u764c \u4e00\u7ebf\u6cbb\u7597\u53ef\u8003\u8651\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u3002 \u3010\u672c\u764c\u79cd\u76f8\u5173\u83b7\u6279\u53ca\u6307\u5357\u63a8\u8350\u836f\u7269\u3011 \u5e15\u5c3c\u5355\u6297\u3001\u8d1d\u4f10\u73e0\u5355\u6297\u3001\u897f\u59a5\u6614\u5355\u6297 \u836f\u7269\u540d\u79f0 \u5e15\u5c3c\u5355\u6297 \u836f\u7269\u8bf4\u660e \u5e15\u5c3c\u5355\u6297\uff08Panitumumab\uff0c Vectibix\uff09\u662f\u91cd\u7ec4\u7684\u4eba\u6e90\u5316 IgG2 \u5355\u6297\uff0c \u7279\u5f02\u6027\u7ed3\u5408\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53 \uff08EGFR\uff09\u3002 \u5e15\u5c3c\u5355\u6297\u4e0e\u80de\u5916\u7684 EGFR \u7279\u5f02\u6027\u7ed3\u5408\uff0c \u7ade\u4e89\u6027\u5730\u6291\u5236\u914d\u4f53\u4e0e EGFR \u7ed3\u5408\uff0c \u53ef\u963b\u65ad\u914d\u4f53\u8bf1\u5bfc\u7684 \u53d7\u4f53\u81ea\u78f7\u9178\u5316\u548c\u53d7\u4f53\u76f8\u5173\u6fc0\u9176\u7684\u6fc0\u6d3b\uff0c \u4ece\u800c\u6291\u5236\u7ec6\u80de\u751f\u957f\uff0c \u8bf1\u5bfc\u7ec6\u80de\u51cb\u4ea1\uff0c \u964d\u4f4e\u4fc3\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u548c\u8840\u7ba1 \u751f\u957f\u56e0\u5b50\u7684\u4ea7\u751f\u3002 \u83b7\u6279\u9002\u5e94\u75c7 FDA \u6279\u51c6\u5176\u7528\u4e8e\uff1a1\uff09\u5355\u836f\u6cbb\u7597\u5148\u524d\u63a5\u53d7\u6807\u51c6\u5316\u7597\uff08\u542b\u6c1f\u5c3f\u5627\u5576\u3001\u5965\u6c99\u5229\u94c2\u3001\u4f0a\u7acb\u66ff\u5eb7\uff09\u540e\u53d1\u751f\u75be\u75c5\u8fdb \u5c55\u7684 RAS \u91ce\u751f\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff1b 2\uff09\u8054\u5408\u5316\u7597\uff08FOLFOX\uff09\u7528\u4e8e RAS \u91ce\u751f\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u7684\u4e00\u7ebf \u6cbb\u7597\u3002 \u836f\u7269\u7597\u6548 PRIME \u7814\u7a76\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u7684 III \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c \u5171\u5165\u7ec4 1183 \u4f8b\u665a\u671f\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\uff0c \u6309 1:1 \u968f\u673a\u5206\u914d\u5230\u5e15\u5c3c\u5355\u6297\u8054\u5408 FOLFOX \u7ec4\u53ca FOLFOX \u5355\u836f\u7ec4\uff0c \u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u4e3a\u65e0\u8fdb\u5c55\u751f\u5b58\u671f PFS\u3002 \u7ed3 \u679c\u663e\u793a\uff0c\u5bf9\u4e8e KRAS \u91ce\u751f\u578b mCRC \u60a3\u8005\uff0c\u4e0e\u5355\u7528 FOLFOX \u65b9\u6848\u76f8\u6bd4\uff0c\u5e15\u5c3c\u5355\u6297\u8054\u5408 FOLFOX \u65b9\u6848\uff0c\u53ef \u4ee5\u660e\u663e\u6539\u5584\u60a3\u8005\u7684 PFS\uff089. 6 \u4e2a\u6708 vs. 8.\n</details>"], ["\u5e15\u5c3c\u5355\u6297\u662f\u4ec0\u4e48\uff1f", "\u5e15\u5c3c\u5355\u6297\uff08Panitumumab\uff0cVectibix\uff09\u662f\u4e00\u79cd\u91cd\u7ec4\u7684\u4eba\u6e90\u5316 IgG2 \u5355\u6297\uff0c\u7279\u5f02\u6027\u7ed3\u5408\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u3002\u5b83\u7528\u4e8e\u6cbb\u7597\u67d0\u4e9b\u7c7b\u578b\u7684\u7ed3\u80a0\u764c\uff0c\u5305\u62ec\u5de6\u534a\u7ed3\u80a0\u764c\u548c\u53f3\u534a\u7ed3\u80a0\u764c\u3002\u5e15\u5c3c\u5355\u6297\u901a\u8fc7\u7ade\u4e89\u6027\u5730\u6291\u5236\u914d\u4f53\u4e0eEGFR\u7ed3\u5408\uff0c\u963b\u65ad\u914d\u4f53\u8bf1\u5bfc\u7684\u53d7\u4f53\u81ea\u78f7\u9178\u5316\u548c\u53d7\u4f53\u76f8\u5173\u6fc0\u9176\u7684\u6fc0\u6d3b\uff0c\u4ece\u800c\u6291\u5236\u7ec6\u80de\u751f\u957f\uff0c\u8bf1\u5bfc\u7ec6\u80de\u51cb\u4ea1\uff0c\u964d\u4f4e\u4fc3\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u548c\u8840\u7ba1\u751f\u957f\u56e0\u5b50\u7684\u4ea7\u751f\u3002\u5e15\u5c3c\u5355\u6297\u5df2\u7ecf\u83b7\u5f97\u4e86FDA\u7684\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u5148\u524d\u63a5\u53d7\u6807\u51c6\u5316\u7597\u540e\u8fdb\u5c55\u7684RAS\u91ce\u751f\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff0c\u4ee5\u53ca\u8054\u5408\u5316\u7597\u7528\u4e8eRAS\u91ce\u751f\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3002"], ["\u8d1d\u4f10\u73e0\u5355\u6297\u662f\u4ec0\u4e48\uff1f", "<p>\u8d1d\u4f10\u73e0\u5355\u6297\uff08Bevacizumab\uff0cAnetumab 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["\u8d1d\u4f10\u73e0\u5355\u6297\u662f\u4ec0\u4e48\uff1f", 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<summary>\u51fa\u5904 [1] xx_ZL0123936.pdf</summary>\n1 \u9875/\u5171 36 \u9875 8\u59d3\u540d\uff1a\u8096\u84d3 | \u62a5\u544a\u7f16\u53f7\uff1a502491 \u5b89\u62e9\u5eb7 \u00ae 1. 3\u4e34\u5e8a\u7528\u836f\u63d0\u793a 1. 3. 1 \u9776\u5411\u7528\u836f\u63d0\u793a \u654f\u611f\u836f\u7269 \u3010\u672c\u764c\u79cd\u83b7\u6279/\u6307\u5357\u63a8\u8350\u3011 \u5e15\u5c3c\u5355\u6297\u3001\u8d1d\u4f10\u73e0\u5355\u6297\u3001\u897f\u59a5\u6614\u5355\u6297 \u53ef\u80fd\u654f\u611f\u836f\u7269 \u3010\u5176\u4ed6\u764c\u79cd\u83b7\u6279/\u4e34\u5e8a\u8bd5\u9a8c\u3011 JW55\u3001AZD1775\u3001APR-246\u3001Ganetespib\u3001G007-LK\u3001\u897f\u7f57\u83ab\u53f8 \u8010\u836f\u836f\u7269 \u3010\u672c\u764c\u79cd\u83b7\u6279\u53ca\u6307\u5357\u6536\u5f55\u8bc1\u636e\u3011 \u65e0 \u53ef\u80fd\u8010\u836f\u836f\u7269 \u3010\u4e34\u5e8a\u7814\u7a76/\u5176\u4ed6\u764c\u79cd\u8010\u836f\u63d0\u793a\u3011 \u65e0 \u8865\u5145\u8bf4\u660e\uff1a 1.\n</details><details> <summary>\u51fa\u5904 [2] xx_ZL0123936.pdf</summary>\n03) \u65e0 \u65e0 \u65e0 \u65e0 TP53: NM_000546: exon7: c. 743G>A: p. R248Q (\u7a81\u53d8\u4e30\u5ea6: 50. 70%) \u65e0 Ganetespib (4 \u7ea7); AZD1775 (4 \u7ea7) \u65e0 APR-246 (3B \u7ea7) KRAS \u91ce\u751f\u578b; NRAS \u91ce\u751f\u578b; BRAF \u91ce\u751f\u578b \u5e15\u5c3c\u5355\u6297 (1 \u7ea7); \u897f\u59a5\u6614\u5355\u6297 (1 \u7ea7); \u8d1d\u4f10\u73e0\u5355\u6297 (2 \u7ea7) \u65e0 \u65e0 \u65e0 \u57fa\u56e0\u53d8\u5f02 \u672c\u764c\u79cd\u7528\u836f\u63d0\u793a \u8de8\u764c\u79cd\u7528\u836f\u63d0\u793a \u654f\u611f (1 \n</details><details> <summary>\u51fa\u5904 [3] xx_ZL0123936.pdf</summary>\n0 \u4e2a\u6708\uff0cP=0. 02\uff09\uff0c\u4f7f\u5176\u603b\u751f\u5b58\u671f OS \u660e\u663e\u5ef6\u957f 4. 4 \u4e2a\u6708\uff0823. 8 \u4e2a\u6708 vs. 19. 4 \u4e2a\u6708\uff09\u3002 \u9776\u70b9 EGFR \u836f\u7269\u540d\u79f0 \u8d1d\u4f10\u73e0\u5355\u6297 \u836f\u7269\u8bf4\u660e \u8d1d\u4f10\u73e0\u5355\u6297\uff08Bevacizum ab\uff0c \u5b89\u7ef4\u6c40/Avastin\uff09\u662f\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u6291\u5236\u5242\uff0c \u662f\u4e00\u79cd\u91cd\u7ec4\u7684\u4eba\u6e90\u5316\u5355\u514b \u9686\u6297\u4f53\uff0c \u5305\u542b\u4eba\u6e90\u7247\u6bb5\u548c\u9f20\u6e90\u7ed3\u6784\uff0c \u4eba\u6e90\u5316\u90e8\u5206\u53ef\u5ef6\u957f\u5176\u534a\u8870\u671f\uff0c \u964d\u4f4e\u514d\u75ab\u539f\u6027\u3002 \u8d1d\u4f10\u73e0\u5355\u6297\u7ed3\u5408\u5e76\u6291 \u5236 VEGF \u6d3b\u6027\uff0c\u963b\u6b62\u8840\u7ba1\u5185\u76ae\u751f\u957f\u548c\u5185\u76ae\u7ec6\u80de\u589e\u6b96\uff0c\u4ece\u800c\u963b\u65ad\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u8840\u6db2\u4f9b\u5e94\uff0c\u6291\u5236\u80bf\u7624\u7684\u6269 \u6563\u3002\n</details>"], ["\u97e6\u7389\u519b\u662f\u8c01\uff1f", "\u4f5c\u4e3a\u4e00\u4e2a\u4eba\u5de5\u667a\u80fd\u52a9\u624b\uff0c\u6211\u65e0\u6cd5\u786e\u5b9a\u201c\u97e6\u7389\u519b\u201d\u6307\u7684\u662f\u54ea\u4e00\u4e2a\u4eba\uff0c\u56e0\u4e3a\u8fd9\u4e2a\u540d\u5b57\u53ef\u80fd\u6307\u4ee3\u8bb8\u591a\u4e0d\u540c\u7684\u4eba\u3002\u97e6\u7389\u519b\u53ef\u80fd\u662f\u4e00\u4e2a\u666e\u901a\u4eba\uff0c\u4e5f\u53ef\u80fd\u662f\u4e00\u4e2a\u540d\u4eba\u6216\u8005\u5386\u53f2\u4eba\u7269\u3002\u5982\u679c\u60a8\u53ef\u4ee5\u63d0\u4f9b\u66f4\u591a\u4fe1\u606f\uff0c\u4f8b\u5982\u97e6\u7389\u519b\u7684\u804c\u4e1a\u3001\u56fd\u7c4d\u3001\u5386\u53f2\u4e8b\u4ef6\u7b49\uff0c\u6211\u4f1a\u5c3d\u529b\u63d0\u4f9b\u66f4\u8be6\u7ec6\u7684\u4fe1\u606f\u3002"], ["\u97e6\u7389\u519b\u662f\u8c01\uff1f", "\u97e6\u7389\u519b\u662f\u4e00\u4f4d\u4e2d\u56fd\u79d1\u5b66\u5bb6\uff0c\u4ed6\u662f\u5317\u4eac\u5927\u5b66\u3001\u6e05\u534e\u5927\u5b66\u548c\u9999\u6e2f\u79d1\u6280\u5927\u5b66\u8054\u5408\u57f9\u517b\u9879\u76ee\u7684\u4e3b\u4efb\uff0c\u4e5f\u662f\u4e00\u4f4d\u6559\u6388\u3002\u4ed6\u7684\u7814\u7a76\u65b9\u5411\u4e3b\u8981\u96c6\u4e2d\u5728\u751f\u547d\u79d1\u5b66\u548c\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u9886\u57df\uff0c\u5305\u62ec\u751f\u7269\u5206\u5b50\u5f71\u50cf\u5b66\u3001\u751f\u7269\u4fe1\u606f\u5b66\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\u7b49\u3002\u97e6\u7389\u519b\u6559\u6388\u5728\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u9886\u57df\u505a\u51fa\u4e86\u5f88\u591a\u8d21\u732e\uff0c\u5e76\u4e14\u83b7\u5f97\u4e86\u8bb8\u591a\u8363\u8a89\u548c\u5956\u9879\u3002"], [null, "\u5df2\u6dfb\u52a0 \u5b89\u9f99\u57fa\u56e0\u5ba3\u4f20\u518c.pdf \u5185\u5bb9\u81f3\u77e5\u8bc6\u5e93\uff0c\u5e76\u5df2\u52a0\u8f7d\u77e5\u8bc6\u5e93\uff0c\u8bf7\u5f00\u59cb\u63d0\u95ee"], [null, "\u5df2\u6dfb\u52a0 \u5185\u5bb9\u81f3\u77e5\u8bc6\u5e93\uff0c\u5e76\u5df2\u52a0\u8f7d\u77e5\u8bc6\u5e93\uff0c\u8bf7\u5f00\u59cb\u63d0\u95ee"], ["\u97e6\u7389\u519b\u662f\u8c01\uff1f", "\u97e6\u7389\u519b\uff08Wei Yujun\uff09\u53ef\u80fd\u662f\u67d0\u4e2a\u5177\u4f53\u7684\u4eba\u7269\uff0c\u4f46\u5173\u4e8e\u5177\u4f53\u7684\u97e6\u7389\u519b\uff0c\u6ca1\u6709\u660e\u786e\u7684\u516c\u5f00\u4fe1\u606f\u53ef\u4ee5\u786e\u8ba4\u8fd9\u4e2a\u8eab\u4efd\u3002\u5982\u679c\u60a8\u9700\u8981\u4e86\u89e3\u67d0\u4e2a\u5177\u4f53\u7684\u4eba\u7269\u4fe1\u606f\uff0c\u8bf7\u60a8\u63d0\u4f9b\u66f4\u591a\u7684\u80cc\u666f\u548c\u8be6\u7ec6\u4fe1\u606f\uff0c\u4ee5\u4fbf\u6211\u4e3a\u60a8\u63d0\u4f9b\u66f4\u51c6\u786e\u7684\u7b54\u6848\u3002"]] |