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org/page/clinAnnLevels\uff0c \u5171\u5206\u4e3a 4 \u4e2a\u7b49\u7ea7\uff1a 1A\uff1a\u7531\u4e34\u5e8a\u836f\u7269\u57fa\u56e0\u7ec4\u5b66\u5b9e\u65bd\u8054\u76df\uff08CPIC\uff09\u6216\u9057\u4f20\u836f\u7406\u5b66\u6307\u5357\u8ba4\u53ef\uff0c \u6216\u5728\u9057\u4f20\u836f\u7406\u5b66\u7814\u7a76\u7f51\u7edc (PGRN) \u53ca\u5176\u5b83\u4e3b\u8981\u536b\u751f\u7cfb\u7edf \u4e2d\u5df2\u6709\u5e94\u7528\uff1b\n</details><details> <summary>\u51fa\u5904 [3] xx_ZL0123936.pdf</summary>\n \u5b89\u5fbd\u7701\u5408\u80a5\u5e02\u5e90\u9633\u533a\u961c\u9633\u5317\u8def\u4e0e\u5317\u57ce\u5927\u9053\u4ea4\u53e3\u521b\u667a\u5929\u5730 A6 \u53f7\u697c (400-801-9858) \u7b2c 34 \u9875/\u5171 36 \u9875 \u59d3\u540d\uff1a\u8096\u84d3 | \u62a5\u544a\u7f16\u53f7\uff1a502491 \u5b89\u62e9\u5eb7 \u00ae 3. 5\u9644\u5f55\u4e94\uff1a\u57fa\u56e0\u68c0\u6d4b\u62a5\u544a\u8bf4\u660e 01 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\u4e2a\u57fa\u56e0\u70ed\u70b9\u533a\u57df \u5171\u68c0\u51fa\u57fa\u56e0\u7a81\u53d8\u4f4d\u70b9\uff1a109 \u4e2a \u5177\u6709\u4e34\u5e8a\u610f\u4e49\u4f4d\u70b9\uff1a6\u4e2a \u514d\u75ab\u6cbb\u7597\u7597\u6548\u8bc4\u4f30 \u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08TMB\uff09 TMB-H \uff1a39. 44 Muts/Mb \u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\uff08MSI\uff09 MSS \u9519\u914d\u4fee\u590d\u57fa\u56e0\uff08MMR\uff09 \u81f4\u75c5/\u7591\u4f3c\u81f4\u75c5\u53d8\u5f02\uff1a1 \u4e2a \u5316\u7597\u7597\u6548\u53ca\u6bd2\u526f\u4f5c\u7528 \u5316\u7597\u836f\u7269\u7597\u6548\u53ca\u6bd2\u526f\u4f5c\u7528 \u6709\u6548\u6027\u8f83\u9ad8\u836f\u7269\uff1a4 \u4e2a \u6bd2\u526f\u4f5c\u7528\u8f83\u4f4e\u836f\u7269\uff1a6 \u4e2a \u9057\u4f20\u98ce\u9669\u8bc4\u4f30 \u9057\u4f20\u6613\u611f\u57fa\u56e0\u68c0\u6d4b\u7ed3\u679c \u81f4\u75c5/\u7591\u4f3c\u81f4\u75c5\u53d8\u5f02\uff1a0 \u4e2a \u5b89\u5fbd\u7701\u5408\u80a5\u5e02\u5e90\u9633\u533a\u961c\u9633\u5317\u8def\u4e0e\u5317\u57ce\u5927\u9053\u4ea4\u53e3\u521b\u667a\u5929\u5730 A6 \n</details><details> <summary>\u51fa\u5904 [2] xx_ZL0123936.pdf</summary>\n\u643a \u5e26\u8be5\u5206\u5b50\u7279\u5f81\u7684\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\uff08mCRPC\uff09 \u60a3\u8005\u53ef\u80fd\u5bf9 PARP \u6291\u5236\u5242\u53ca\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICIs\uff09 \u654f\u611f\u3002 \u7814\u7a76\u8868\u660e\uff0c \u643a\u5e26 CDK12 \u53cc\u7b49\u4f4d\u57fa\u56e0\u7f3a\u5931 mCRPC \u60a3\u8005\u53ef\u80fd\u5bf9\u514d\u75ab\u6cbb\u7597\u6709\u66f4\u9ad8\u7684\u53cd\u5e94\uff0c 4 \u4f8b CDK12 \u5931\u6d3b \u7a81\u53d8 mCRPC \u4e2d\uff0c 2 \u4f8b\u5bf9 PD-1 \u5355\u836f\u6cbb\u7597\u6709\u6548\uff08PMID\uff1a 29906450\uff09\u3002 \u57fa\u56e0 \u514d\u75ab\u6cbb\u7597 \u76f8\u5173\u6027 \u68c0\u6d4b\u7ed3\u679c \u53d8\u5f02\u89e3\u6790 \u68c0\u6d4b\u610f\u4e49 \u3010\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3011 ALK \u8d1f\u76f8\u5173 \u672a\u89c1\u76f8\u5173\u53d8\u5f02 \n</details><details> <summary>\u51fa\u5904 [3] xx_ZL0123936.pdf</summary>\n\u800c KRAS/TP53 \u53cc\u7a81\u53d8\u7684\u80ba\u817a\u764c\u53ef\u80fd\u6fc0\u53d1\u708e\u75c7\u578b\u514d\u75ab\u5fae\u73af \u5883\uff0c \u663e\u8457\u589e\u52a0\u80ba\u817a\u764c PD-L1 \u8868\u8fbe\u53ca PD-L1+/TIL+ \u53cc\u9633 \u6027\u6bd4\u4f8b\uff0c \u5177\u6709\u66f4\u5f3a\u7684\u514d\u75ab\u539f\u6027\uff0c \u53ef\u80fd\u662f\u6297 PD-1 \u514d\u75ab\u6cbb \u7597\u7684\u6f5c\u5728\u9884\u6d4b\u6807\u5fd7\u7269\u3002 TP53 \u6b63\u76f8\u5173 p. R213X; p. R248Q \u53ef\u80fd\u7684\u529f\u80fd\u5931 \u6d3b\u6027\u81f4\u764c\u53d8 \u5f02; \u53ef\u80fd\u7684\u529f\u80fd\u5931 \u6d3b\u6027\u81f4\u764c\u53d8\u5f02 \u57fa\u56e0 \u514d\u75ab\u6cbb\u7597 \u76f8\u5173\u6027 \u68c0\u6d4b\u7ed3\u679c \u53d8\u5f02\u89e3\u6790 \u68c0\u6d4b\u610f\u4e49 \u5b89\u5fbd\u7701\u5408\u80a5\u5e02\u5e90\u9633\u533a\u961c\u9633\u5317\u8def\u4e0e\u5317\u57ce\u5927\u9053\u4ea4\u53e3\u521b\u667a\u5929\u5730 A6 \u53f7\u697c (400-801-9858) \u7b2c 15 \u9875/\u5171 36 \u9875 \n</details>"], ["\u654f\u611f\u836f\u7269\u662f\u4ec0\u4e48\uff1f", 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\u6279\u51c6\u53ca\u6307\u5357\u63a8\u8350\u7528\u4e8e\u672c\u764c\u79cd\u7684\u9776\u5411\u836f\u7269\uff1b 2. \u82e5\u6837\u672c\u540c\u65f6\u68c0\u51fa\u654f\u611f\u7a81\u53d8\u548c\u8010\u836f\u7a81\u53d8\uff0c\u7528\u836f\u65f6\u8bf7\u7efc\u5408\u8003\u8651\uff0c\u7528\u836f\u5faa\u8bc1\u8be6\u89c1 2. 2\u8282\u3002 \u7528\u836f\u9700\u9075\u533b\u5631\uff0c\u8c28\u614e\u7528\u836f\u3002 1. 3. 2 \u514d\u75ab\u7528\u836f\u63d0\u793a \u514d\u75ab\u6307\u6807 \u68c0\u6d4b\u7ed3\u679c \u7ed3\u679c\u89e3\u8bfb TMB TMB-H \u7528\u836f\u8be6\u89c1 2. 3. 1\u8282 MSI MSS \u7528\u836f\u8be6\u89c1 2. 3. 2\u8282 \u8865\u5145\u8bf4\u660e\uff1a 1.\n</details>"], ["\u4e34\u5e8a\u5e38\u89c4\u9776\u5411\u836f\u7269\u57fa\u56e0\u68c0\u6d4b\u7ed3\u679c\u662f\u4ec0\u4e48\uff1f", 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\u6211\u4eec\u575a\u4fe1\uff0c\u6562\u4e8e\u76f4\u9762\u80bf\u7624\u7684\u60a8\u4e0d\u4ec5\u662f\u751f\u547d\u7684\u52c7\u58eb\uff0c\u66f4\u662f\u751f\u6d3b\u7684\u5f3a\u8005\uff01 \u5728\u6218\u80dc\u80bf\u7624\u7684\u9053\u8def\u4e0a\uff0c\u6211\u4eec\u4e3a\u60a8\u79d1\u5b66\u62a4\u822a\uff0c\u4e0e\u60a8 \u4e00\u8d77\u6218\u6597\uff01\n</details><details> <summary>\u51fa\u5904 [2] xx_ZL0123936.pdf</summary>\n1 \u9001\u68c0\u4fe1\u606f 1 1. 2 \u68c0\u6d4b\u9879\u76ee\u53ca\u7ed3\u679c 1 1. 3 \u4e34\u5e8a\u7528\u836f\u63d0\u793a 2 1. 3. 1 \u9776\u5411\u7528\u836f\u63d0\u793a 2 1. 3. 2 \u514d\u75ab\u7528\u836f\u63d0\u793a 2 1. 3. 3 \u5316\u7597\u7528\u836f\u63d0\u793a 2 02 \u68c0\u6d4b\u7ed3\u679c\u8be6\u7ec6\u89e3\u8bfb 2. 1 \u4e34\u5e8a\u5e38\u89c4\u9776\u5411\u836f\u7269\u57fa\u56e0\u68c0\u6d4b\u7ed3\u679c 3 2. 2 \u9776\u5411\u57fa\u56e0\u7ed3\u679c\u89e3\u8bfb 4 2. 3 \u514d\u75ab\u6cbb\u7597\u76f8\u5173\u68c0\u6d4b\u7ed3\u679c\u89e3\u8bfb 9 2. 3. 1 \u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08TMB\uff09 9 2. 3. 2 \u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\uff08MSI\uff09 11 2. 3. 3 DNA \u9519\u914d\u4fee\u590d\u57fa\u56e0\uff08MMR\uff09 12 2. 3.\n</details><details> <summary>\u51fa\u5904 [3] xx_ZL0123936.pdf</summary>\n\u7528\u836f\u9700\u9075\u533b\u5631\uff0c\u8c28\u614e\u7528\u836f\u3002 1. 3. 3 \u5316\u7597\u7528\u836f\u63d0\u793a \u5177\u4f53\u5206\u6790\u7ed3\u679c\u89c1 2. 4\u8282\u3002 \u5b89\u5fbd\u7701\u5408\u80a5\u5e02\u5e90\u9633\u533a\u961c\u9633\u5317\u8def\u4e0e\u5317\u57ce\u5927\u9053\u4ea4\u53e3\u521b\u667a\u5929\u5730 A6 \u53f7\u697c (400-801-9858) \u7b2c 2 \u9875/\u5171 36 \u9875 \u59d3\u540d\uff1a\u8096\u84d3 | \u62a5\u544a\u7f16\u53f7\uff1a502491 \u5b89\u62e9\u5eb7 \u00ae 02\u68c0\u6d4b\u7ed3\u679c\u8be6\u7ec6\u89e3\u8bfb Detailed analysis of test results 2. 1\u4e34\u5e8a\u5e38\u89c4\u9776\u5411\u836f\u7269\u57fa\u56e0\u68c0\u6d4b\u7ed3\u679c \u672c\u5217\u8868\u5c55\u793a\u6307\u5357\u53ca\u5171\u8bc6\u63a8\u8350\u68c0\u6d4b\u5b9e\u4f53\u7624\u76f8\u5173\u70ed\u70b9\u57fa\u56e0\u7684\u7a81\u53d8\u60c5\u51b5\uff1a AKT1 \u70b9\u7a81\u53d8 \u9634\u6027 - - ALK \n</details><details> <summary>\u51fa\u5904 [4] xx_ZL0123936.pdf</summary>\n3. 4 \u6f5c\u5728\u5f71\u54cd\u514d\u75ab\u6cbb\u7597\u7597\u6548\u7684\u57fa\u56e0\u68c0\u6d4b\u7ed3\u679c \u5b89\u62e9\u5eb7\u2013NGS \u5b9e\u4f53\u7624 658 \u57fa\u56e0 TMB \u68c0\u6d4b\u5305\u542b\u4e0e\u514d\u75ab\u6cbb\u7597\u7597\u6548\u76f8\u5173\u57fa\u56e0\uff1a\u6b63\u76f8\u5173\u3001\u8d1f\u76f8\u5173\u4ee5\u53ca\u8d85\u8fdb\u5c55\u76f8\u5173\u57fa\u56e0\uff0c \u8fd9\u4e9b\u57fa\u56e0 \u6765\u6e90\u4e8e\u90e8\u5206\u764c\u79cd\u7684\u4e34\u5e8a\u524d\u6216\u521d\u671f\u7814\u7a76\u7ed3\u679c\uff0c \u68c0\u6d4b\u7ed3\u679c\u4ec5\u4f9b\u4e34\u5e8a\u53c2\u8003\u3002 \u3010\u5b9e\u4f53\u7624\u3011 MLH1 \u6b63\u76f8\u5173 \u672a\u89c1\u76f8\u5173\u53d8\u5f02 - - DNA \u9519\u914d\u4fee\u590d\u57fa\u56e0\uff08MMR\uff09\u53d1\u751f\u81f4\u75c5\u6216\u7591\u4f3c\u81f4\u75c5\u53d8\u5f02 \u65f6\uff0c\u53ef\u80fd\u4f1a\u5bfc\u81f4 MSI-H \u6216 dMMR\uff0c\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236 \u5242\uff08ICIs\uff09\u7597\u6548\u5448\u6b63\u76f8\u5173\u3002\n</details>"], ["\u836f\u7269\u8be2\u8bc1\u662f\u6307\u4ec0\u4e48\uff1f", "<p>\u836f\u7269\u8be2\u8bc1\u662f\u6307\u9488\u5bf9\u53d7\u68c0\u8005\u80bf\u7624\u7c7b\u578b\uff0c\u6240\u5217\u751f\u7269\u6807\u5fd7\u7269\u4e0e\u836f\u7269\u54cd\u5e94\u5173\u7cfb\u7684\u8bc1\u636e\u6765\u6e90\u3002\u672c\u62a5\u544a\u6240\u91c7\u7528\u836f\u7269\u8be2\u8bc1\u7b49\u7ea7\u662f\u5728\u80bf\u7624\u7cbe\u51c6\u7528\u836f\u6570\u636e\u5e93 OncoKB \u836f\u7269\u8be2\u8bc1\u7b49\u7ea7\u7684\u57fa\u7840\u4e0a\uff0c\u878d\u5165 NMPA \u836f\u54c1\u8bf4\u660e\u4e66\u53ca\u56fd\u5185\u6307\u5357\u5171\u8bc6\u53ca\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u636e\uff0c\u5171\u5212\u5206\u4e3a 6 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\u7a81\u53d8\u4e30\u5ea6\uff1a\u67d0\u4e2a\u57fa\u56e0\u4f4d\u70b9\u7684\u7a81\u53d8\u7b49\u4f4d\u57fa\u56e0\u5360\u6240\u6709\u7b49\u4f4d\u57fa\u56e0\u7684\u6bd4\u4f8b\uff0c\u5373\u7b49\u4e8e\u7a81\u53d8\u578b/\uff08\u7a81\u53d8\u578b + \u91ce\u751f\u578b\uff09\uff0c\u4e00\u822c\u9488\u5bf9\u70b9\u7a81\u53d8\u6216 \u5c0f\u7247\u6bb5\u63d2\u5165\u7f3a\u5931\u60c5\u51b5\uff1b \u62f7\u8d1d\u6570\uff1a\u53d7\u68c0\u8005\u57fa\u56e0\u62f7\u8d1d\u6570\u53d8\u5316\u60c5\u51b5\uff0c\u4ee5 2 \u4e3a\u6b63\u5e38\u503c\u3002 \u7a81\u53d8\u4e30\u5ea6\u548c\u62f7\u8d1d\u6570\u53d7\u80bf\u7624\u7ec6\u80de\u542b\u91cf\u548c\u53d6\u6750\u7b49\u56e0 \u7d20\u7684\u5f71\u54cd\u3002 3. \u672c\u62a5\u544a\u68c0\u6d4b\u7ed3\u679c\u53ca\u7528\u836f\u63a8\u8350\u4ec5\u4f9b\u4e34\u5e8a\u53c2\u8003\uff0c\u5177\u4f53\u9700\u4e34\u5e8a\u533b\u751f\u7ed3\u5408\u60a3\u8005\u5b9e\u9645\u60c5\u51b5\u786e\u5b9a\u5408\u7406\u7684\u6cbb\u7597\u65b9\u6848\u3002\n</details><details> <summary>\u51fa\u5904 [2] 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A212A 1. 70% COSV58998843 \u201c.\u201d\u8868\u793a\u8be5\u7a81\u53d8\u672a\u6709 cosmic \u6570\u636e\u5e93\u8bb0\u5f55 - - \u57fa\u56e0\u62f7\u8d1d\u6570\u5206\u6790\u7ed3\u679c - - \u57fa\u56e0 \u67d3\u8272\u4f53\u4f4d\u7f6e \u62f7\u8d1d\u6570 JUN chr1 9. 03 - - \u57fa\u56e0\u91cd\u6392\u5206\u6790\u7ed3\u679c - - 5 \u2032 \u7aef\u7a81\u53d8 3 \u2032 \u7aef\u7a81\u53d8 \u53d8\u5f02 \u57fa\u56e0 \u8f6c\u5f55\u672c \u5916\u663e\u5b50 \u57fa\u56e0 \u8f6c\u5f55\u672c \u5916\u663e\u5b50 \u7a81\u53d8\u4e30\u5ea6 - - - - - - - - - - - - - - - - \u5b89\u5fbd\u7701\u5408\u80a5\u5e02\u5e90\u9633\u533a\u961c\u9633\u5317\u8def\u4e0e\u5317\u57ce\u5927\u9053\u4ea4\u53e3\u521b\u667a\u5929\u5730 A6 \u53f7\u697c (400-801-9858) \u7b2c 25 \u9875/\u5171 36 \u9875 \u59d3\u540d\uff1a\u8096\u84d3 | \u62a5\u544a\u7f16\u53f7\uff1a502491 \u5b89\u62e9\u5eb7 \u00ae - - \u80da\u7cfb\u81f4\u75c5\u6027\u53d8\u5f02\u5206\u6790\u7ed3\u679c - - \u57fa\u56e0 \u8f6c\u5f55\u672c \u5916\u663e\u5b50 \u6838\u82f7\u9178\u53d8\u5f02 \u6c28\u57fa\u9178\u53d8\u5f02 \u7a81\u53d8\u4e30\u5ea6 \u4e34\u5e8a\u610f\u4e49 - - - - - - - - - - - - - - - - \u672a\u68c0\u6d4b\u5230\u53d8\u5f02\u7684\u70ed\u70b9\u57fa\u56e0 - - CDKN2B PDGFRA SMAD4 HRAS ATM EGFR RET CTNNB1 AKT1 MAP2K1 EZH2 RAD51B EPCAM FH BRIP1 TSC2 ROS1 TSC1 RAD51D BAP1 \n</details>"]] |