data/YM_0693/README.md

PP489 Optimization Variants Iter0 x TIGIT (YM_693)

Overview

YM_693 is a dataset of anti-TIGIT designs against TIGIT. This dataset contains only 2 targets, but they are species homologs of human and mouse. The designs offer a few mutations to study the local interaction between and TIGIT. This is a dataset to explore relative affinities to the parent for antibody optimization.

Experimental details

We studied the efficacy of generating binders with different model hyperparameters. This dataset includes 26726 unique scFvs and 2 unique target sequences.

A more extensive methods section can be found in our publication here.

Misc dataset details

We define the following binders:

A-library (scFvs)

There are several terms you can filter by:

• wt_<i>: These are WT replicates.
• candidate_: Various mutations of PP489

Alpha-library

• TIGIT_22-137_POI-AGA2: Human TIGIT
• TIGIT_Mouse: Mouse TIGIT