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The secretory immune system. | Several features distinguish mucosal from systemic immunity; depending on the anatomical and functional characteristics of the organs involved. Secretory IgA immunoglobulins are the main effectors of the mucosal immune system and their protective aspects are well documented. Serum IgA have received less attention but are equally important; since they control and remove in a non-phlogistic way antigens crossing the mucosal barriers. | 2634626 | [
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Cachectin/tumour necrosis factor-alpha in the circulation of patients with rheumatic disease. | By means of a sensitive double-antibody radioimmunoassay; cachectin/tumour necrosis factor-alpha (TNF) was measured in sera from 51 patients with rheumatic disease. Elevated levels of circulating cachectin/TNF were observed in 46% of patients with rheumatoid arthritis (RA; p less than 0.001 versus blood donors) and in 29% of patients with systemic lupus erythematosus (SLE; p less than 0.05 versus blood donors). Marked elevation of cachectin/TNF occurred in both RA and SLE patients in connection with severe | 2634628 | [
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Cachectin/tumour necrosis factor-alpha in the circulation of patients with rheumatic disease. | infections. The results show that cachectin/TNF is present in the circulation of certain patients with rheumatic disease; and that although the median cachectin TNF level in SLE patients is lower than that in RA patients; the cachectin/TNF response in SLE patients to severe infections is similar to that in RA patients. | 2634628 | [
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Anti-inflammatory activity of Teucrium polium. | Teucrium polium is widely used by the folk-medicine practitioners in Saudi Arabia for the treatment of inflammations; rheumatism; diabetes and ulcers. Scientific reports are lacking to confirm these activities. The present study reports the effect of ethanolic extract of T. polium on carrageenan-induced acute inflammation; cotton-pellet granuloma and some of the biochemical parameters. The ethanolic extract of Teucrium polium at a dose of 500 mg/kg body weight produced significant inhibition of carrageenan- | 2634627 | [
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Anti-inflammatory activity of Teucrium polium. | induced inflammation and cotton-pellet granuloma. Biochemical studies showed a significant decrease in glucose level. The presence of flavonoids and sterols might be responsible for the anti-inflammatory activity of this plant. Further studies on the fractionation of the phytoconstituents; and on their mechanism of action are in progress. | 2634627 | [
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Utilities and quality-adjusted life years. | Utilities and quality-adjusted life years (QALYs) are reviewed; with particular focus on their use in technology assessment. This article provides a broad overview and perspective on these two techniques and their interrelationship; with reference to other sources for details of implementation. The historical development; assumptions; strengths/weaknesses; and applications of each are summarized. Utilities are specifically designed for individual decision-making under uncertainty; but; with additional assum | 2634630 | [
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Utilities and quality-adjusted life years. | ptions; utilities can be aggregated across individuals to provide a group utility function. QALYs are designed to aggregate in a single summary measure the total health improvement for a group of individuals; capturing improvements from impacts on both quantity of life and quality of life--with quality of life broadly defined. Utilities can be used as the quality-adjustment weights for QALYs; they are particularly appropriate for that purpose; and this combination provides a powerful and highly useful varia | 2634630 | [
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Advances in prenatal diagnosis. Social-psychological and policy issues. | Chorionic villus sampling (CVS); a new technique for prenatally diagnosing chromosomal and genetic disorders; may soon replace amniocentesis. This procedure; performed by inserting a catheter through the pregnant woman's cervix or through the abdomen and removing cells from the placenta; has the advantages of being available earlier in the pregnancy than amniocentesis (at 9 to 11 weeks gestational age) and of yielding results in a shorter time. Although the medical aspects of the procedure are being investi | 2634631 | [
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Advances in prenatal diagnosis. Social-psychological and policy issues. | gated; its psychosocial and policy implications have not been studied systematically. These issues include the subjective assessment of risk that prompts women to choose or to reject CVS; the implications of earlier diagnosis for feelings about abortion; the potential of negative findings (i.e.; the absence of the designated disorder) for well-being during the remainder of the pregnancy; the ramifications of first trimester identification of fetal sex; equity of access to prenatal diagnosis; and the possibl | 2634631 | [
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Advances in prenatal diagnosis. Social-psychological and policy issues. | e over-utilization of these procedures. Drawing on previous research regarding amniocentesis and more recent research concerning CVS; this article discusses the potential implications of CVS. | 2634631 | [
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Outcome-based equity in the treatment of colon cancer patients in Finland. | The differences in survival rates of colon cancer patients between hospital districts were used as an indicator of equity in cancer treatment in Finland. The merits of two different assessment methods were evaluated. The large variation was mainly due to confounding by age and the extent of the disease and to random variation. | 2634632 | [
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Head injury. Variability of course and presence of confounding factors. | Review of a large data base on 76 patients who had suffered head injuries and whose metabolic changes were being studied demonstrated the variability of their neurological courses and the importance of considering confounding factors in the analysis of such a group. It was apparent that many such patients continue to change neurologically and functionally for long periods of time; and that their ultimate outcome cannot be determined for at least 1 year. The study demonstrates the inherent complexity of a gr | 2634633 | [
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Head injury. Variability of course and presence of confounding factors. | oup of patients with head injuries and the need to use sophisticated statistical tools and a computer to demonstrate whether apparent trends are statistically valid in light of confounding factors and variabilities. Failure to take this complexity into account seems to be a major factor in many of the ongoing controversies in research on head injuries. A possible solution to the problem of potential biases introduced by lost patients would be to develop a method to use government records to obtain current a | 2634633 | [
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Head injury. Variability of course and presence of confounding factors. | ddresses for patients involved in federally funded research. | 2634633 | [
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Multifocal fractures of the femur. | Multifocal fractures of the femur in modern traumatology are becoming more and more frequent and often pose difficult problems of treatment. In view of the sparse contributions on this subject in the literature; we analysed our series of 33 cases with a view to formulating our conclusions as to the best type of treatment. Because of the varied associations of different types of fracture in a single skeletal segment; there is no single method of synthesis applicable to all cases. The various means of synthes | 2634634 | [
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Multifocal fractures of the femur. | is at our disposal (Küntscher nail; Grosse Kempf blocked nail; Ender nail; AO plates and screws; external fixators) should be selected depending on the individual case; respecting the concept of closed surgery as much as possible. This requires imagination as well as experience. | 2634634 | [
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The results of reconstruction of the anterior cruciate ligament with semitendinosus and gracilis tendons in chronic laxity of the knee. | The authors report the medium term results (41 months) in 88 patients submitted to surgery for reconstruction of the anterior cruciate ligament according to the method currently in use at our Clinic which uses the semitendinosus and gracilis tendons. The results were evaluated according to a score card method and in 28 patients a KT-1000 arthrometer was also used. The method gives a probability of full success in approximately 85% of cases; with significantly better results in patients not submitted to meni | 2634635 | [
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