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Among the anti-herpesvirus agents , aciclovir , valaciclovir , penciclovir , famciclovir , idoxuridine , trifluridine and brivudin are used in the treatment of herpes simplex virus and varicella-zoster virus infections , and ganciclovir , foscarnet , cidofovir , fomivirsen and maribavir ( the latter in the developmental stage ) are used in the treatment of cytomegalovirus infections . | [] |
The present study examined the efficacy of single and combined treatment with an anticholinesterase , tetrahydroaminoacridine ( i.p . ) , and a glycine-B site partial agonist , D-cycloserine ( i.p . ; a positive allosteric modulator of NMDA receptors ) , in alleviating the deficit in water maze spatial navigation induced by electrolytic lesion of the medial septum or lidocaine infusion into the dorsal hippocampi . | [] |
He was initially treated with combination chemotherapy regimen of vincristine , actinomycin-D and cyclophosphamide ( VAC therapy ) . | [{'class': 'COMB', 'spans': ['vincristine', 'cyclophosphamide', 'actinomycin-D'], 'is_context_needed': True}] |
However , when a lung mass was noted two months later , he started to receive combination chemotherapy consisting of cyclophosphamide , adriamycin , vincristine , and prednisolone every three months . | [{'class': 'COMB', 'spans': ['cyclophosphamide', 'vincristine', 'prednisolone', 'adriamycin'], 'is_context_needed': True}] |
Three patients treated initially with propranolol alone have required substitution of amiodarone due to refractory congestive heart failure . | [] |
We used MCF-7 and MDA-MB231 breast cancer cells incubated with Curcumin and Quercetin for 24h , in the absence and presence of Somatostatin , at their EC50 concentrations , to evaluate membrane fatty acid-based functional lipidomics together with the follow-up of EGFR and MAPK signaling pathways . | [{'class': 'COMB', 'spans': ['Curcumin', 'Somatostatin', 'Quercetin'], 'is_context_needed': True}] |
Following corneal scrapings and culture , topical 0.5 % moxifloxacin and 0.5 % tobramycin were administered hourly . | [{'class': 'COMB', 'spans': ['moxifloxacin', 'tobramycin'], 'is_context_needed': True}] |
Combination treatment with cetuximab and nystatin selectively increased cetuximab uptake by tumor tissues , translating into potentiated antitumor efficacy of cetuximab in vivo ( A431 and A549 tumors ) . | [{'class': 'POS', 'spans': ['cetuximab', 'nystatin'], 'is_context_needed': False}] |
The effects of combination therapy with chenodeoxycholic acid ( CDCA ) and simvastatin on serum cholestanol , low-density lipoprotein ( LDL ) cholesterol , and lathosterol levels were investigated in seven adult patients with cerebrotendinous xanthomatosis ( CTX ) who were on long-term treatment with CDCA . | [{'class': 'POS', 'spans': ['chenodeoxycholic', 'simvastatin'], 'is_context_needed': True}] |
Paclitaxel ( Taxol ; Bristol-Myers Squibb Company , Princeton , NJ ) has been demonstrated to be highly effective in treating patients with advanced breast cancer , including those with anthracycline-resistant breast cancer , a fact that has led to efforts to combine paclitaxel and anthracyclines . | [{'class': 'COMB', 'spans': ['paclitaxel', 'anthracyclines'], 'is_context_needed': True}] |
However , anastrozole , exemestane and letrozole are associated with significantly fewer endometrial cancers , as well as venous and arterial vascular events , when compared with tamoxifen [ 9 , 10 ] . | [] |
Additivity , synergy , or competition was observed with MIS and rapamycin , AzadC , doxorubicin , cisplatin , and paclitaxel , suggesting that MIS in combination with selective targeted therapies might achieve greater activity against ovarian cancer than the use of each individual agent alone . | [{'class': 'POS', 'spans': ['rapamycin', 'MIS'], 'is_context_needed': False}, {'class': 'POS', 'spans': [3, 4], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 3], 'is_context_needed': False}] |
There was no cytotoxic effect of cisplatin , ifosfamide , and etoposide . | [] |
Several first-line phase III trials , as well as ongoing trials for which only preliminary results have been published , have fueled debates on the optimal dose and schedule ; these have focused not only on weekly vs q3-weeks paclitaxel , but also on other modifications and the advisability of adding bevacizumab . | [{'class': 'COMB', 'spans': ['paclitaxel', 'bevacizumab'], 'is_context_needed': True}] |
The primary goal was achieve the correct estimation of the target plasma area against the topotecan concentration-time curve ( AUC ) in a 5 day course of cladribine followed by monitored topotecan in pediatric patients with recurrent/refractory AML . | [{'class': 'COMB', 'spans': ['cladribine', 'topotecan'], 'is_context_needed': True}] |
The management of EP is challenging : no standardized guidelines exist with literature suggesting cyclosporine or infliximab as first-line therapy . | [] |
As single agents , curcumin and metformin are reported to exhibit chemopreventive properties , in vitro as well as in patients with oral cancer . | [] |
Withdrawal rates were comparable to drug survival rates of other biological therapies and rates of adverse events were similar between brodalumab and ustekinumab . | [] |
In patients with NPSLE , the use of high-dose corticosteroids is recommended in combination with immunosuppressants , such as mycophenolate mofetil and intravenous cyclophosphamide pulse therapy . | [{'class': 'POS', 'spans': ['mycophenolate', 'corticosteroids'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 2], 'is_context_needed': False}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': False}] |
Thirty-three women diagnosed with metastatic breast cancer participated in a phase 1 clinical trial of a new combination of cyclophosphamide ( CTX ) and mitoxantrone ( MXT ) , with dose escalation of paclitaxel . | [{'class': 'COMB', 'spans': ['cyclophosphamide', 'mitoxantrone', 'paclitaxel'], 'is_context_needed': True}] |
These studies suggest a slight advantage to the combined approaches that contain flutamide and bicalutamide , but the lack of dramatic differences in outcome makes monotherapy reasonable , especially in patients with more indolent disease . | [{'class': 'POS', 'spans': ['flutamide', 'bicalutamide'], 'is_context_needed': False}] |
We examined the feasibility and safety of using paclitaxel and trastuzumab as maintenance therapy after high-dose chemotherapy ( HDC ) with autologous hematopoietic stem cell transplantation ( AHST ) for patients with HER2-positive metastatic breast cancer . | [{'class': 'POS', 'spans': ['paclitaxel', 'trastuzumab'], 'is_context_needed': True}] |
Dual antiplatelet therapy with aspirin and clopidogrel ( the preferred thienopyridine because of its superior hematologic safety ) is recommended for at least 4 weeks to prevent subacute stent thrombosis with bare-metal stents and 3 to 6 months to prevent late-stent thrombosis with drug-eluting stents . | [{'class': 'POS', 'spans': ['aspirin', 'clopidogrel'], 'is_context_needed': False}] |
Furthermore , in non-metastatic castration-resistant prostate cancer ( M0 CRPC ) , two second-generation anti-androgens , apalutamide and enzalutamide , when used in combination with ADT , have demonstrated a significant benefit in metastasis-free survival . | [{'class': 'POS', 'spans': ['apalutamide', 'ADT'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 2], 'is_context_needed': False}] |
A screening method based on liquid chromatography-electrospray mass spectrometry for the simultaneous determination of six corticosteroids ( betamethasone 17-valerate BM 17-V , beclomethasone BC , beclomethasone dipropionate BCDP , methylprednisolone MP , budesonide BD , flunisolide FN ) was developed in order to control their illegal use in cosmetic and natural products . | [] |
Phase Ib Study of the Oral Proteasome Inhibitor Ixazomib ( MLN9708 ) and Fulvestrant in Advanced ER+ Breast Cancer Progressing on Fulvestrant . | [{'class': 'POS', 'spans': ['Ixazomib', 'Fulvestrant'], 'is_context_needed': True}] |
Second-Line Treatment of Her2-Positive Metastatic Breast Cancer : Trastuzumab beyond Progression or Lapatinib ? A Population Based Cohort Study . | [] |
Pharmacokinetic studies showed that chronic lymphocytic leukemia involving more than 80 % of the bone marrow at study start was associated with lower trough concentrations of alemtuzumab and rituximab , and that higher trough serum concentrations of alemtuzumab were associated with complete bone marrow clearance . | [{'class': 'POS', 'spans': ['alemtuzumab', 'rituximab'], 'is_context_needed': True}] |
Furthermore , the overall response rate for docetaxel in the intent-to-treat population ( 42.5 % ) is superior to the response rate of either doxorubicin as second-line therapy ( 29.3 % ) or paclitaxel ( Taxol ; Bristol-Myers Squibb Oncology , Princeton , NJ ) when used as first- or second-line therapy ( 29 % ) in metastatic disease . | [] |
Correlation of lidocaine induced changes in bladder capacity , compliance and number of uninhibited contractions with improvement on oral oxybutynin was 70.6 % , 64.3 % and 66.7 % , respectively . | [] |
Compared with risedronate alone , at 6 months , risedronate plus atorvastatin produced significantly greater increases in the bone mineral density of the lumbar spine ( 1.58 % versus 0.75 % , p < 0.05 ) . | [{'class': 'POS', 'spans': ['risedronate', 'atorvastatin'], 'is_context_needed': False}] |
The anti-CD22 immunoconjugate , inotuzumab ozogamicin , and the anti-CD19 BiTE ( ® ) antibody , blinatumomab , have demonstrated impressive single agent activity in patients with relapsed or refractory B-ALL . | [] |
Patients registered with the German ACC Registry with refractory ACC progressing after cytotoxic therapies were offered treatment with bevacizumab ( 5 mg/kg body weight i.v . every 21 days ) and oral capecitabine ( 950 mg/m(2 ) twice daily for 14 days followed by 7 days of rest ) in 2006 - 2008 . | [{'class': 'NEG', 'spans': ['bevacizumab', 'capecitabine'], 'is_context_needed': True}] |
Patients who had pathologically been proven to have measurable lesions were treated with paclitaxel ( 200 mg/m(2 ) for 3 h ) and carboplatin [ area under the concentration-time curve ( AUC = 6 ) ] on day 1 and in 21 day cycles . | [{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}] |
With regard to efficacy in metastatic disease , exemestane is superior to megestrol acetate after progression on tamoxifen . | [] |
Aim of the study was to measure plasma levels of specific miRNAs ( miRNA-223 , -150 , -21 and -126 ) after physician-driven cessation of chronic P2Y12 inhibition and to study differences in the expression levels of these miRNAs between the different oral P2Y12 inhibitors clopidogrel , prasugrel and ticagrelor , respectively . | [] |
Eligible patients received ramucirumab ( 10mg/kg ) + dacarbazine ( 1000 mg/m(2 ) ) ( Arm A ) or ramucirumab only ( 10mg/kg ) ( Arm B ) every 3 weeks . | [{'class': 'POS', 'spans': ['ramucirumab', 'dacarbazine'], 'is_context_needed': True}] |
The aim of this study was to investigate the mutagenic and antigenotoxic effects of different doses of the flavonoid , apigenin , alone and in combination with the antitumor drugs , cyclophosphamide and doxorubicin , in vitro and in vivo . | [{'class': 'POS', 'spans': ['apigenin', 'doxorubicin'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 1], 'is_context_needed': True}] |
The novel agents , romidepsin , pralatrexate , and brentuximab vedotin , are currently approved in the relapsed/refractory setting . | [] |
More effective regimens are urgently needed for squamous cell carcinoma of esophagus ( SCCE ) , therefore , we conducted a phase I/II trial of a combination of docetaxel , platinum , and fluorouracil ( TPF ) for treating metastatic SCCE . | [{'class': 'POS', 'spans': ['docetaxel', 'platinum'], 'is_context_needed': True}] |
Gemcitabine with cyclosporine or with tacrolimus exerts a synergistic effect and induces tolerance in the rat . | [{'class': 'POS', 'spans': ['Gemcitabine', 'cyclosporine'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}] |
Erythropoietin receptor expression and its relationship with trastuzumab response and resistance in HER2-positive breast cancer cells . | [] |
Both paclitaxel ( Taxol ; Bristol-Myers Squibb Company , Princeton , NJ ) and ifosfamide have been demonstrated to be active agents in patients with clinically defined platinum-refractory ovarian cancer . | [] |
All M. simiae complex species proved susceptible to clarithromycin and , to a lesser extent , rifabutin , clofazimine , streptomycin and moxifloxacin . | [] |
Drug exposure of mesenchymal HCC cells showed higher resistance to the targeted therapeutic agents sorafenib and erlotinib as compared to epithelial HCC cells , which were slightly more resistant to cytostatic drugs . | [] |
To compare the effectiveness and safety of adalimumab and infliximab in biologic-naïve patients with CD , in a nationwide register-based propensity score-matched cohort study in Denmark . | [] |
Hematologic National Cancer Institute Common Toxicity Criteria grade 3 to 4 adverse events were more common with bendamustine than with chlorambucil ( occurring in 40 % v 19 % of patients ) . | [] |
We determined the effects of diclofenac sodium , octreotide , and their combination on extrapancreatic organ injuries in caerulein-induced acute pancreatitis in mice . | [{'class': 'COMB', 'spans': ['diclofenac', 'octreotide'], 'is_context_needed': True}] |
Caspofungin and amphotericin B association has been shown to be synergistic in vitro and effective in murine models . | [{'class': 'POS', 'spans': ['Caspofungin', 'amphotericin'], 'is_context_needed': False}] |
Canine leishmaniosis is most frequently treated with the drugs meglumine antimoniate , allopurinol , amphotericin B , or a combination of meglumine antimoniate and allopurinol . | [{'class': 'POS', 'spans': ['meglumine', 'allopurinol'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 2, 5], 'is_context_needed': False}] |
Haloperidol , carbamazepine and levomepromazine were then discontinued . | [{'class': 'COMB', 'spans': ['Haloperidol', 'carbamazepine'], 'is_context_needed': True}] |
Recent clinical work has questioned the safety of a combined therapy of oral quinidine and intravenous verapamil , because some patients were reported to react with severe hypotension probably due to drug interactions with vascular alpha-adrenergic receptors . | [{'class': 'NEG', 'spans': ['quinidine', 'verapamil'], 'is_context_needed': False}] |
The mean duration of total ( i.v . and oral ) therapy was significantly shorter for the azithromycin group than for the cefuroxime group ( 6.2 days vs 10.1 days ) . | [] |
To increase the dose-intensity of two drugs in metastatic breast cancer , we tested the feasibility , in phase I studies , of two schedules of epirubicin ( E ) and cyclophosphamide ( C ) - sequential ( E-- > C ) and alternating ( E/C ) - with respect to the standard combination ( EC ) . | [{'class': 'POS', 'spans': ['epirubicin', 'cyclophosphamide'], 'is_context_needed': True}] |
On February 3 , 2015 , the FDA granted accelerated approval to palbociclib ( IBRANCE , Pfizer Inc. ) , an inhibitor of cyclin-dependent kinases 4 and 6 ( CDK4 and CDK6 ) , for use in combination with letrozole for the treatment of postmenopausal women with estrogen receptor (ER)-positive , HER2-negative advanced breast cancer as initial endocrine-based therapy for their metastatic disease . | [{'class': 'POS', 'spans': ['palbociclib', 'letrozole'], 'is_context_needed': False}] |
a combination treatment : estramustine phosphate , cyproterone acetate or estrogens plus bromocriptine . | [{'class': 'POS', 'spans': ['estramustine', 'cyproterone'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': True}] |
Hormone induced elevations in temperature and possibly other unidentified factors during thyroid crisis may facilitate the triggering of MH following halothane and succinylcholine challenge . | [{'class': 'COMB', 'spans': ['halothane', 'succinylcholine'], 'is_context_needed': True}] |
Mitomycin C plus vinblastine is an effective and well-tolerated regimen for anthracycline resistant cancer . | [{'class': 'POS', 'spans': ['Mitomycin', 'vinblastine'], 'is_context_needed': False}] |
An angiotensin 2 type 1 receptor blocker , olmesartan , and a calcium channel blocker , azelnidipine , possess not only an antihypertensive effect but also an antioxidative effect and other beneficial effects . | [{'class': 'POS', 'spans': ['olmesartan', 'azelnidipine'], 'is_context_needed': False}] |
Forty patients with metastatic breast cancer who had received no previous cytotoxic therapy were treated with a combination chemotherapy program CMF ( P ) , which included methotrexate , 60 mg/m2 , and 5-fluorouracil , 700 mg/m2 intravenously on the first and eighth days , in addition to cyclophosphamide , 100 mg/m2 , and prednisone , 40 mg/m2 , by mouth daily from the first to the fourteenth day of a 28-day cycle . | [{'class': 'POS', 'spans': ['methotrexate', 'cyclophosphamide', 'prednisone', '5-fluorouracil'], 'is_context_needed': True}] |
At present , it seems to us that progress has not been made since Grignani reported a phase II cohort trial of sorafenib and sorafenib combined with everolimus for advanced osteosarcoma , which , in a sense , have become a milestone as a second-line therapy for osteosarcoma . | [{'class': 'COMB', 'spans': ['sorafenib', 'everolimus'], 'is_context_needed': True}] |
Failure to sedate patients who might be aware of paralysis occurred in three of 25 succinylcholine and eight of 94 pancuronium uses . | [] |
Thirty-one isolates were classified as resistant to amprolium , 23 resistant to monensin , 10 resistant to diclazuril , and 6 resistant to clopidol . | [] |
Thirteen patients with interstitial cystitis diagnosed by the NIH criteria were treated with intravesical electromotive administration of lidocaine and dexamethasone followed by cystodistention . | [{'class': 'POS', 'spans': ['lidocaine', 'dexamethasone', 'cystodistention'], 'is_context_needed': True}] |
Drug therapy included omega-3 fish oil , extended-release niacin , colesevelam hydrochloride , and a fixed combination of 10-mg ezetimibe and 40-mg simvastatin . | [{'class': 'POS', 'spans': ['omega-3', 'niacin', 'colesevelam hydrochloride', 'ezetimibe', 'simvastatin'], 'is_context_needed': True}] |
Twenty-one Japanese colorectal cancer patients received intravenous FOLFIRI ( bolus irinotecan , folinic acid , and fluorouracil followed by 46-hour fluorouracil infusion ) followed by bevacizumab ( 5 mg/kg ) in Cycle 1 . | [{'class': 'COMB', 'spans': ['irinotecan', 'folinic acid', 'fluorouracil', 'fluorouracil', 'bevacizumab'], 'is_context_needed': True}] |
Patients received vinorelbine starting at 20 mg/m(2 ) ( to 25 mg/m(2 ) ) and carboplatin area under the curve ( AUC ) 2.5 in divided-doses , both given on Days 1 and 8 every 21-day cycle for up to 6 cycles or until disease progression . | [{'class': 'POS', 'spans': ['vinorelbine', 'carboplatin'], 'is_context_needed': True}] |
Dexamethasone exhibited the highest effect on paclitaxel anti-tumor activity , in a dose-dependent fashion . | [{'class': 'COMB', 'spans': ['Dexamethasone', 'paclitaxel'], 'is_context_needed': True}] |
The first available studies demonstrate the value of these compounds with an improved prognosis of metastatic patients in combination with endocrine therapy ( palbociclib , ribociclib ) or in monotherapy ( abemaciclib ) . | [] |
Flunarizine pretreatment abolished the augmented behavioral response to repeated cocaine administration while diltiazem was less effective . | [] |
We therefore explored the in vitro combination of amphotericin B with itraconazole against 14 clinical Aspergillus fumigatus isolates ( 9 itraconazole susceptible and 5 itraconazole resistant ) with a colorimetric broth microdilution checkerboard technique using two drug interaction models able to explore complicated patterns of interactions : the response surface analysis of Bliss independence and the isobolographic analysis of Loewe additivity zero interaction theories . | [{'class': 'POS', 'spans': ['amphotericin', 'itraconazole'], 'is_context_needed': True}] |
This study evaluated the safety and efficacy of inotuzumab ozogamicin ( INO ) , a targeted humanized anti-CD22 antibody conjugated to calicheamicin , plus rituximab ( R-INO ) every 3 weeks , up to six cycles , followed by high dose therapy and autologous stem cell transplant ( HDT-aSCT ) in patients with high-risk relapsed/refractory diffuse large B-cell lymphoma ( DLBCL ) . | [{'class': 'COMB', 'spans': ['inotuzumab', 'rituximab', 'HDT-aSCT'], 'is_context_needed': True}] |
These are the first 2 reports of successful treatment of this condition by use of a combination of methylprednisolone and mycophenolate mofetil , and , in 1 of the cases , additional medication with intravenous immunoglobulin . | [{'class': 'POS', 'spans': ['methylprednisolone', 'mycophenolate'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 1, 2], 'is_context_needed': False}] |
The introduction of the selective serotonin reuptake inhibitors , moclobemide and mianserin has been a major advance in the treatment of depression , and is already leading to major shifts in the pattern of antidepressants prescribing . | [] |
Four of these had equivocal plasma levels of both norepinephrine and epinephrine , suggesting that overnight clonidine suppression may be of particular value when tumor secretion is intermittent or low . | [] |
In conclusion , concurrent introduction of ATGAM and tacrolimus is a promising therapeutic combination for GVHD refractory to steroids and cyclosporine . | [{'class': 'POS', 'spans': ['ATGAM', 'tacrolimus'], 'is_context_needed': False}] |
Comparison of geometric least-squares mean PK parameters between arms showed no impact of pertuzumab on the PK of trastuzumab or docetaxel . | [{'class': 'COMB', 'spans': ['pertuzumab', 'trastuzumab'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}] |
This study was designed to test the hypothesis that positively charged dendrimers form a complex with enoxaparin , a low-molecular weight heparin ( LMWH ) , and that the resulting drug-dendrimer complex is effective in preventing deep vein thrombosis after pulmonary administration . | [] |
We proved experimentally the use of ECEEM for multiplex determination of kinetic parameters describing weak ( 3 mM > K(d ) > 80 μM ) and fast ( 0.25 s ≥ τ ≥ 0.9 ms ) noncovalent interactions between four small molecule drugs ( ibuprofen , S-flurbiprofen , salicylic acid and phenylbutazone ) and α- and β-cyclodextrins . | [{'class': 'COMB', 'spans': ['ibuprofen', 'β-cyclodextrins'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [1, 4], 'is_context_needed': True}, {'class': 'COMB', 'spans': [3, 4], 'is_context_needed': True}] |
We evaluated the stem cell mobilization regimen of high-dose ifosfamide plus etoposide in 32 patients with epithelial ovarian cancer , who had a positive second-look laparatomy or recurrent disease . | [{'class': 'COMB', 'spans': ['ifosfamide', 'etoposide'], 'is_context_needed': True}] |
Esomeprazole , a proton-pump inhibitor ( PPI ) , is the S-isomer of omeprazole . | [] |
This increase in the number of vasopressin and oxytocin containing neurons in the pig hypothalamus is much later in development than has ever been reported so far . | [] |
Combinations of alkylating agents and fludarabine or cladribine are also synergistic in producing significantly enhanced activity against refractory lymphoid malignancies , but at the cost of increased haematological toxicity . | [{'class': 'COMB', 'spans': ['alkylating agents', 'fludarabine'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}] |
The pharmacodynamic effects of single doses of trazodone ( 100 mg ) , amitriptyline ( 50 mg ) or placebo either alone or with ethanol ( 0.5 ml/kg ) were investigated in 6 healthy volunteers in a double-blind crossover study . | [{'class': 'COMB', 'spans': ['trazodone', 'ethanol'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [1, 2], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 3], 'is_context_needed': True}] |
A 70-year-old Asian man was diagnosed with PVT two months after initiating 5-fluorouracil/leucovorin , irinotecan , and bevacizumab therapy for rectal cancer with liver metastases . | [{'class': 'COMB', 'spans': ['5-fluorouracil/leucovorin', 'irinotecan', 'bevacizumab'], 'is_context_needed': True}] |
Results of cell viability assays revealed that treatment with a combination of imatinib and chemotherapy agents irinotecan or 5‑Fu synergistically inhibited cell growth , compared with treatment with any of these drugs alone . | [{'class': 'POS', 'spans': ['imatinib', 'irinotecan'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}] |
We concluded that ifosfamide is an active agent even in patients with tumours resistant to cyclophosphamide . | [] |
The combination of a fluoropyrimidine ( 5-fluorouracil or capecitabine ) with either oxaliplatin or irinotecan has been widely accepted as standard cytotoxic chemotherapy for either the first- or second-line treatment of mCRC . | [{'class': 'COMB', 'spans': ['fluoropyrimidine', 'oxaliplatin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}] |
In 1517 poor prognosis patients , 21 regimens were used , the commonest being CAV , EV ( etoposide , vincristine ) , CbE , CAV alternating with PE , and oral etoposide . | [] |
Utilizing this data , we suggest that nivolumab plus ipilimumab and cabozantinib may be favored for first-line treatment of specific populations of older patients . | [{'class': 'POS', 'spans': ['nivolumab', 'ipilimumab', 'cabozantinib'], 'is_context_needed': False}] |
The aim of this study was to evaluate all E. coli positive blood cultures collected during a 4-y period in a haematological department using piperacillin plus netilmicin for empiric treatment of febrile episodes . | [{'class': 'COMB', 'spans': ['piperacillin', 'netilmicin'], 'is_context_needed': True}] |
Thirty-five percent ( 6 of 17 ) of the patients receiving docetaxel alone and 53 % ( 19 of 36 ) of those receiving docetaxel and thalidomide have had a PSA decrease of at least 50 % . | [{'class': 'POS', 'spans': ['docetaxel', 'thalidomide'], 'is_context_needed': True}] |
Evidence-based guidelines recommend nicotine replacement therapy , bupropion SR , and varenicline as effective alternatives for smoking cessation therapy , especially when combined with behavioral interventions . | [] |
The efficacy of methotrexate ( MTX ) as a single graft-versus-host disease ( GVHD ) prophylaxis agent was compared to that of cyclosporin A ( CSA ) in 62 pediatric patients ( median age : 8 years ) with hematological malignancies who had undergone bone marrow transplantation ( BMT ) from HLA-identical sibling donors at National Kyushu Cancer Center since 1977 . | [] |
Owing to the wide spread activation of this pathway in numerous neoplasms , trametinib and cobimetinib are being studied in combination with other targeted and cytotoxic drugs in a variety of clinical situations . | [] |
All these isolates were found to survive in presence of heavy metals like cadmium , lead and zinc and were resistant to antibiotics like ampicillin , tetracycline , streptomycin , penicillin and chloramphenicol as indicated by their Minimum Inhibitory Concentrations ( MIC ) . | [] |
Reduction of ASS1 expression by siRNA significantly sensitized mesothelioma spheroids to the pro-apoptotic effects of bortezomib and of cisplatin plus pemetrexed . | [{'class': 'POS', 'spans': ['pemetrexed', 'cisplatin'], 'is_context_needed': False}] |
In conclusion , the combination of thalidomide and cyclosporine in subtherapeutic doses may be useful for the treatment of skin allografts . | [{'class': 'POS', 'spans': ['thalidomide', 'cyclosporine'], 'is_context_needed': False}] |
We now wish to report that , under these conditions , the pss-8 mutant is hypersensitive to certain antibiotics , especially to streptomycin , kanamycin , and gentamicin , although also to ampicillin and novobiocin . | [] |
During the first 5 min of cooling , CVC decreased at control sites ( lactated Ringer solution ) to -45 + /- 6 % ( P < 0.001 ) , increased at adrenoceptor-antagonized sites ( yohimbine + propranolol ) to 15 + /- 14 % ( P = 0.002 ) , and remained unchanged at both Rho kinase-inhibited ( fasudil ) and adrenoceptor-antagonized + Rho kinase-inhibited sites ( yohimbine + propranolol + fasudil ) ( -9 + /- 1 % , P = 0.4 and -6 + /- 2 % , P = 0.4 , respectively ) . | [] |