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BigScience Biomedical Datasets 112

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This finding is different from that in our previous analysis of the original survey data, in which AOD use was unrelated to major depression after controlling for other social and behavioural variables (Mao et al. 2009b).

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Given that BARE-2 is a chimera between BARE-1 and WIS-2 [25], the likelihood is that sequences adjacent to the arrays must have undergone multiple rounds of recombination.

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The 28-item Dissociative Experiences Scale–II (DES-II) measures the frequency of psychoform dissociative experiences on a 0–100 scale (Bernstein & Putnam, 1986; Carlson & Putnam, 1993).

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Rutin (3,3′,4′,5,7-pentahydroxyflavone-3-rhamnoglucoside, Figure 2) also called sophorin, rutoside, and quercetin-3rutinoside is a polyphenolic bioflavonoid, largely extracted from natural sources such as oranges, lemons, grapes, limes, berries, and peaches [30, 31].

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topology: a package for performing structural analysis – the current version contains the reporter metabolites algorithm of Patil & Nielsen [22].

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Previous work revealed that Dusp6 mutant mice exhibit increased pERK and Erm expression, skeletal dwarfism, craniosynostosis, and hearing loss [21].

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Butanol tolerance is a complex phenotype involving multiple loci (Makarova et al., 2006; Papoutsakis, 2008; Winkler et al., 2010), making the engineering of strains with enhanced tolerance to this solvent difficult.

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pro-hypertrophic effector mechanisms regulated by GATA4 is ANP [14] which is in turn suppressed by sorafenib treatment.

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Among possible explanations is the contribution of sex hormones in the modulation of Tregs.34 Treg-mediated local immune evasion underpins the second finding of our study, i.e. the positive association between higher FOXP3-positive T cells and the presence of VELIPI.

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The most common reported mechanisms are CSF and hematogenous dissemination [3].

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Surveys, based on The Organisational Values Questionnaire (OVQ) developed by Reino [9] and Resistance to Change Scale (RTC) developed by Oreg [8], were sent out to 4 hospital wards in a medical clinic in Sweden.

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(Costa et al., 2013; Thabtah et al., 2004), have pointed out that the minsupp threshold often controls the numbers of rules generated and the training time consumed during the rule discovery and production steps.

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…and (b) Logical Memory (LM) standard scores for immediate and delayed (30-minute delay) recall subtests from the Wechsler Memory Scale— Revised (WMS-R; Wechsler, 1987) with more recent normative data for the LM subtest from the Mayo’s Older Americans Normative Studies (MOANS; Ivnik et al., 1992).

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Quinolinic acid (Sigma, St. Louis) was used to lesion the hippocampal formation and caudate nucleus (Schwartz et al., 1983) as described (Worley et al., 1986a).

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, in the massive MIMO regime, the channel becomes (nearly) deterministic and the effect of smallscale fading is averaged out [8].

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Overall, changes in pattern of species richness may disrupt marine biodiversity and ecosystems, and impact commercial fisheries (Roessig et al. 2004; Worm et al. 2006; Cheung et al. 2008b).

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In addition, a precise supracondylar osteotomy with the desired angle is a technically demanding procedure and placement of a plate requires a rather large incision [4, 10, 17, 19, 23, 30].

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[46] reported improved model performance to predict the presence of prairie fish species if information on reach and catchment scale are combined.

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Insulin resistance, defined as cellular unresponsiveness to the effects of insulin, results in increasingly higher levels of insulin needed to achieve normal glucose levels [1, 4].

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…reduced engagement of medial temporal regions during the construction of future events in depressed patients (Hach et al., 2014), which is consistent with the reduced episodic detail and vividness of mental imagery that is associated with this disorder (Holmes et al., 2008b; King et al., 2011).

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Activated PERK blocks protein synthesis by phosphorylating eIF2α [13], and the phosphorylation makes ATF4, a transcription factor, to translocate into the nucleus, and induce the transcription of genes needed to restore ER homeostasis (i.

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Flow cytometry Flow cytometric analyses were performed on dissociated embryonic pancreatic cells from MIP-GFP mice using FACSAria II (BD Biosciences) (see ESM Methods).

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Synchronization is the most commonly-used method [1], [2], [3] to eliminate atomicity violations, which is an important class of concurrency errors [34].

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To assess interobserver variability between two raters of the SYNTAX score, Cohen’s kappa statistics [27] was used after tertile partitioning of their initial SYNTAX scorings.

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Assigning economic values to an environmental function or ecological service has been widely debated, with researchers employing a variety of methodologies [9–11].

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The improved pharmacokinetic and pharmacodynamic parameters of ixazomib compared to bortezomib have made it a focus of investigation for use in combination with other pro-apoptotic agents [11, 14].

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As the rate of periapical abscesses in the CH group was the same as in the induction study [Cleaton-Jones et al., 2002] but that in the ZOE teeth was a quarter of the induction rate, there is a suggestion that ZOE is superior to CH. The higher success rate may also have been influenced by filling to the apex only, as Holan and Fuks [1993] showed clearly that overfilling with ZOE is detrimental to periapical healing. Tchaou et al. [1996] exposed standard bacterial cultures to 10 root filling materials or combinations of these.

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However, as previously discussed, choice of host species has been shown to greatly influence the outcome of a Salmonella infection, and several studies utilizing a variety of advanced model systems have shown that T3SSs are necessary for Salmonella invasion and infection of these models [17,18,19,21,22,23,26,39].

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We reviewed the radiology reports of two subsets of patients: those undergoing CT thorax (pulmonary embolism [PE] protocol) and those undergoing cervical spine CT.

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Thus, herbivory in leaves or roots can induce whole-plant changes in allelochemistry ( Bezemer et al. , 2004; Kaplan et al. , 2008a ), resulting in indirect effects on co-occurring species ( Bezemer et al. , 2003; Soler et al. , 2005, 2007 ; van Dam et al. , 2005 ).

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We evaluate our method on two collective activity datasets from [6,7] and a newly recorded dataset collected by ourselves.

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…is known to be induced by Ras and repressed by p53 signaling (Li et al. 2008) and is involved in the inactivation of extrinsic as well as intrinsic apoptosis pathways, by interacting with pro-apoptotic proteins like p53, Bcl-2, Bax, Bad, PUMA, MSH2, MSH6 and others (Ludwig-Galezowska et al. 2011).

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Similar to Krajcarski et al. (1999), Chiang (in press) concluded that increased muscular activity due to pre-loads leads to increases in trunk muscle stiffness and spine stability.

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Post-translational modification by this ubiquitinlike modifier (ULM) appears to have multifunctional effects and operates in states of tolerance to preserve homeostasis under stress (Tempé et al., 2008).

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Binding of PP1c to scaffold proteins may modulate ion channel activity (44), while at neuronal synapses, neurabins I and II (also termed spinophilin) localize PP1c to the actin cytoskeleton at the plasma membrane (1, 32, 33, 37).

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In this study, the unstimulated flow rate was significantly higher in the asymptomatic group; 0.17, when compared with 0.11 in the symptomatic ⁄AIDS group (P = 0.003).

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5 m plastic boards and were distributed in the field to be used as GCPs for UAS-based image processing [29].

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This last assumption was supported by the thymic model: flutamide exposure has an opposing effect in the thymus as compared with the testis (Olsen et al., 1998; Dulos and Bagchus, 2001).

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This pattern of shifting N and P availability has been observed in a limited number of established long-term substrate age gradients (e.g. Crews et al. 1995; Wardle et al. 2004; Selmants and Hart 2008).

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For the classical ones including DOME and SAFE rules, we used one-shot screening, while for the others, we used a sequential screening setting.

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As a novel biomechanical analysis from video recordings, a Model-Based Image-Matching (MBIM) motion analysis technique has been introduced to investigate human motion from uncalibrated video sequences (Krosshaug and Bahr, 2005).

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Other studies suggest that altering affinity to FcRn might alter the bioavailability of mAbs (Deng et al., 2010; Deng et al., 2012), and SC bioavailability appears lower in FcRn-deficient mice as compared to wild type animals (Wang et al., 2008).

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The diagnosis of cirrhosis was made based on imaging studies and impaired liver synthetic function [10].

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This may demonstrate retroperitoneal air as streaking opacities in the right upper quadrant and outlining the kidney margins and along the psoas muscle [17, 23, 25].

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The insertion of this time delay is critical because in previous work, it has been shown to allow the development of an inhibitory relationship between the outcome and the stimulus that follows; that is, it allows S1 to predict the absence of subsequent O1 delivery and S2 to predict the absence of subsequent O2 delivery; that is, stimuli trained in such manner exhibit properties (such as retardation) identical to those display by other conditioned inhibitors (Rescorla, 1969; Maier et al., 1976; Delamater et al., 2003).

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Level 1 patients require immediate lifesaving interventions, level 2 patients are in a high-risk situation, are lethargic, confused, or have severe pain, and levels 3, 4, and 5 patients need many, 1, or no resources, respectively.(19) All adult (ie, 18 years of age) nontrauma patients were eligible for inclusion to the study, if they had an ESI score of 2 or 3 and vital signs within the normal range and presented in 1 of the 2 EDs between May 24, 2007, and February 8, 2011.

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The high numbers of all three species found in MT confirm the importance of this large, lowland forest block for primate conservation and further support the proposal to restore the Mngeta conservation corridor between US and Iyondo forest, a lowland to montane forest that is contiguous with MT (Rovero et al. 2012; St. John 2008) and is currently under gazettement as forest reserve (N.

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Current evidence also indicates that shear stress activates two MAP kinases by distinct signaling pathways: activation of ERK is mediated by mechanisms involving Gai-2, protein kinases [Src, focal adhesion kinase (FAK), and protein kinase C-e], and Ras, whereas JNK activation requires Gb/g, phosphatidylinositol 3-kinase-g, tyrosine kinases (Src and FAK), and Ras (11, 14, 15, 22, 37).

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…to perform a time calibrated phylogenetic analysis, using three node constraints derived from Santos et al. (2009) in the software Beast 1.7 (Drummond and Rambaut 2007): (1) the divergence between Dendrobates truncatus and Dendrobates auratus was constrained with an uniform prior with an…

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Dense Trajectory features are formed by the sequence of displacement vectors in an optical flow field, together with the HoG-HoF descriptor (Laptev et al, 2008) and the motion boundary histogram (MBH) descriptor (Dalal et al, 2006) computed over a local neighbourhood along the trajectory.

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…by the release of SPEs and other antigens, which function as superantigens (Proft et al., 2003; Marrack and Kappler, 1990; Talkington et al., 1993; Baxter and McChesney, 2000; Eriksson et al., 1999; Darenberg et al., 2004; Norrby-Teglund et al., 2005; Zurawski et al., 1998; Ekelund et al., 2005).

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…negative correlation, such that more positive mean PBR occurred concurrently with a more negative mean NBR, is in agreement with previous studies (Klingner et al., 2010; Shmuel et al., 2002), suggesting that the magnitude of ipsilateral inhibition increases with the magnitude of increasing…

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Mouse IgG 30 lg/ml final concentration was added as control (Schmid et al., 2000; Tang et al., 2006; Yeaney et al., 2009).

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…neighbor matrices, PCNM) as predictors in our analyses as these are suggested to produce inflated R2-statistics apparently due to over-fitting (i.e. selection of too many axes, which may overemphasise the spatial component in the data) even when forward selection is used (Gilbert & Bennett, 2010).

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c-IAP2, which has been functionally implicated in the inhibition of TNF-mediated death, is transcriptionally regulated by NF-kB (40).

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In mitochondria LDH and glycerol-3-phosphate dehydrogenase do not donate electrons to the respiratory chain, yet in bacteria they are membrane-bound enzymes transferring their electrons directly to ubiquinol (Barnes and Kaback 1970; Lascelles 1978; Doig et al. 1999; Modun and Williams 1999; Dym et al. 2000; Delgado et al. 2001; Fuller et al. 2011).

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It is also interesting to note that the proportion of frozenthawed primordial follicles (36%) found after 28 weeks of grafting is comparable to that (41%) found after 3 weeks of grafting [16].

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The results observed in the study carried out by Hallal et al. (2006), which analyzed 4452 Brazilian adolescents, are in accordance with the analyses of Davison et al. (2008).

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Since the first ON1 location in Ontario [Eshaghi et al., 2012], geographical dispersion has been reported worldwide [Choudhary et al.

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We concentrate here on the computational issues, extending the Static Sensor Field model (SSSF) [2], to scenarios in which dynamicity is of relevance.

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To alleviate this, wireless-powered strategy is proposed by making use of radiofrequency (RF) signals emitted from other communication nodes to provide stable energy supply for relay nodes [14– 16].

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The explanation for such finding is not clear, since the pellet dissolves within the proventriculus (Nir et al., 1994c), and thus it was not expected that physical form of the diet would have any effect in this portion of the gastrintestinal tract.

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This implies that about 40% of the study population living in the North would benefit from increasing the duration of solar exposure as presented previously [16].

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Although they mimic many phorbol ester effects, including inhibition of cell-cell communication (25, 26), they have been reported not to induce differentiation of HL-60 cells (27) or to inhibit maturation of granulosa cells (28).

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The observed levels of heavy metal variation in soil samples could be attributed to the varying amount of metals in the irrigation water as well as other agronomic practices of the respective areas (Yadav et al. 2013).

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There is a gradual increase in the double phosphorylation of the Thr-Glu-Tyr motif, characteristic of activated kinases such as ERK1, 2 and 5 in two proteins of 80 and 105 kDa in capacitating human spermatozoa (de Lamirande and Gagnon, 2002; Thundathil et al., 2002, 2003).

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Homeoproteins contain a highly conserved, 60 amino acid peptide domain known as the homeodomain (McGinnis et al., 1984a,b; Laughon and Scott, 1984), a peptide motif conferring sequence-specific DNA binding ability to the homeoproteins (Laughon and Scott, 1984; Desplan et al.

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In informal experiments, it’s found that only inserting LN cannot achieve satisfactory adaptation results, and inspired by [11], we combine fine-tuning output layer with Full-LN/LRPD-LN based method in the following experiments.

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This translocation event is independent of the HBV nucleocapsid and can be subsequently detected on secreted virions and SVP (5, 24).

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Prominent within the HBC are the balls – events in which the houses come together to compete in various categories for cash prizes and ‘ball status’ (Galindo, 2013).

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…tRNA selection on the ribosome during protein synthesis (Blanchard et al., 2004) (reviewed in Johansson et al., 2008; Rodnina et al., 2005), acetylcholine receptor desensitization (Dilger and Brett, 1990; Matsubara et al., 1992), and subunit rotation of F0F1-ATP synthase (Diez et al., 2004).

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This prolongs the circulation time and potential for interaction of the antigen with APCs and may reduce the need for multiple vaccinations [3].

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For group Lasso we have adapted the implementation presented in [21] whereas for comparisons with standard multiple kernel learning, we have used the GMKL implementation presented by Varma and Babu [33].

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The first of these is a class of appearance-based approaches in which a linear subspace is used to capture the variation of a particular face due variations in illumination [8, 2, 11].

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Here we use the value of ten (because our previous study showed this is the number of items that can be managed efficiently in the browser’s sidebar [Moreau et al., 2002]).

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PKCη-C2 domain induces chondrogenic diffe- rentiation in hMSCs The C2 domain of PKCη is thought not to affect substrate-specificity of the kinase but instead aid in its localization to membranous systems (Littler et al., 2006).

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A rook pivoting scheme as in [3] and [11] can be implemented for tridiagonal matrices, but a full rook scheme for general banded matrices would probably lead to a ”chasing” scheme as in [5] or [15] .

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The original architecture proposed in [5] has been improved in [6] by rearranging the detection method (DM) in a modular fashion and by reducing the control management.

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The three-sigma signal is triggered when any data point is further than 3 standard deviations away from the overall process average [11].

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Therefore, the equilibrium and stability analysis of neural networks with time delays has been received much interest in recent years [2, 3, 4, 5, 6, 7, 18, 19, 20, 25, 24, 30, 21, 22, 23, 33].

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Some approaches address the cause of aligning both classes and entities simultaneously: the RiMOM [66] and iliads [98] systems.

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Olfactory bulb odorant ORFs These results are consistent with previously reported studies of mitral–tufted cell responses to odorants differing in carbon chain length (Imamura et al., 1992).

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Amplified neural activity was connected to an analog-to-digital converter (Cambridge Electronic Design) and passed through an integrator circuit (Shimatani et al. 2002).

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If NusA is not present, antitermination still occurs, but in this case there is evidence that antipausing is the mechanism: Restricting elongation rate at the critical release site of an intrinsic terminator by reducing the substrate NTP concentration impairs antitermination in the absence of NusA, but not in its presence (126).

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First, depression is observed at all synaptic connections between layer 5 pyramidal neurons even though U varies from 0.1 to 0.95 (Markram and Tsodyks, 1996, Tsodyks and Markram, 1997).

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Using the identifying restrictions of Baker et al. (2012), I find that the estimated response of the economy to a shock to policy uncertainty is much larger when the last 4 years of data are included in the dataset.

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The reversal component requires orbitofrontal cortex (Dias et al., 1996; Fellows and Farah, 2003; Hornak et al., 2004; Izquierdo et al., 2004; Murray and Izquierdo, 2007).

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As for exposure assessment, underestimation is considered according to the study designs; conversely for outcome and confounding assessment, overestimation is considered (Porta et al. 2009; WHO 2007; Franchini et al. 2004; Giusti 2009).

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The TNM staging of the GBC tumors was assessed according to the American Joint Committee on Cancer (AJCC) guidelines [6].

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17Recently, Davidsson & Sibbertsen (2002) introduced a model which nests the Error Duration model of Parke (1999). One interpretation of the model is that innovations become alive again once they have died.

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The inadequacy of CCS implementation in the primary care setting, which was also reported by physicians’ survey from Italy, France, and Greece [6, 20–25] and by a qualitative study from UK [26], is further strengthened by our results.

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Further comparison with the distribution of 11 -hydroxysteroid dehydrogenase type 2, which is found in the DCT and CNT (4) confirmed the different pattern of expression of RhCG in these segments (Fig.

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The use of a throat pack increased the risk of developing sore throat by more than 3 times; this finding is in contrast to previous studies in which the presence of a throat pack was not found to be a risk factor in the development of POST.17,18 Our patients predominantly underwent ENT surgery, in which it is common to use a throat pack to prevent blood from trickling into the stomach and leading to postoperative nausea and vomiting.

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To block the entire time-course of morphine reward and not just the short time that the animals were in the place-conditioning apparatus immediately after morphine or saline injection, the TPP was reversibly inactivated with the local anesthetic bupivacaine, which has an effect that lasts for at least 2 h (Swerdlow & Jones, 1970; Covino, 1986), compared with the time-course (approximately 30–60 min) of the faster acting anesthetic lidocaine (Covino, 1986).

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It is also offering a wealth of new approaches such as emitters [3, 4] and sensors [5-7] in terms of THz applications.

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It conditions resistance to penicillin, cefotaxime, ceftazidime and aztreonam, and its activity is well inhibited by clavulanic acid, sulbactam and tazobactam [7, 8].

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Because ribbons and short-wavelength folds occur together at the margins of crustal plateaus and show compatible principal strain orientations [Ghent and Hansen, 1999], it is possible that they formed simultaneously, under the principle that the shortest-wavelength tectonic features represent the earliest stages of deformation.

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I estimate a vector autoregression (VAR) that includes the policy uncertainty index created by Baker, Bloom, and Davis (2012).

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Adherence to the healthy Nordic diet was measured, calculating the Baltic Sea Diet Score (BSDS) [13].

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including non-violent crimes, drug abuse, and impulsive disorder, all had increased risk for violence.[9] These results were in line with the results of the present study.