bigbio/scifact · Datasets at Hugging Face

id int32 0 1.41k	claim stringlengths 26 249	evidences list	cited_doc_ids list
509	Hematopoietic Stem Cell purification reaches purity rates above 90%.	[]	[ 13980338 ]
515	High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).	[ { "doc_id": 29564505, "sentence_ids": [ 8 ], "label": "SUPPORT" }, { "doc_id": 29564505, "sentence_ids": [ 13 ], "label": "SUPPORT" } ]	[ 29564505 ]
523	Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.	[ { "doc_id": 14803797, "sentence_ids": [ 1 ], "label": "CONTRADICT" }, { "doc_id": 14803797, "sentence_ids": [ 5 ], "label": "CONTRADICT" } ]	[ 14803797 ]
524	Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.	[ { "doc_id": 14803797, "sentence_ids": [ 1 ], "label": "SUPPORT" }, { "doc_id": 14803797, "sentence_ids": [ 5 ], "label": "SUPPORT" } ]	[ 14803797 ]
526	Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.	[]	[ 3863543 ]
529	Human embryonic stem cells give rise to cell types from all three embryonic germ layers.	[ { "doc_id": 10546779, "sentence_ids": [ 2 ], "label": "SUPPORT" }, { "doc_id": 25413327, "sentence_ids": [ 0 ], "label": "SUPPORT" }, { "doc_id": 25413327, "sentence_ids": [ 5 ], "label": "SUPPORT" }, { "doc_id": 36651210, "sentence_ids": [ 0 ], "label": "SUPPORT" } ]	[ 10546779, 25413327, 36651210 ]
530	Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.	[ { "doc_id": 10546779, "sentence_ids": [ 2 ], "label": "CONTRADICT" }, { "doc_id": 25413327, "sentence_ids": [ 0 ], "label": "CONTRADICT" }, { "doc_id": 25413327, "sentence_ids": [ 5 ], "label": "CONTRADICT" }, { "doc_id": 36651210, "sentence_ids": [ 0 ], "label": "CONTRADICT" } ]	[ 10546779, 25413327, 36651210, 87610599 ]
531	Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.	[ { "doc_id": 10546779, "sentence_ids": [ 2 ], "label": "SUPPORT" }, { "doc_id": 25413327, "sentence_ids": [ 0 ], "label": "SUPPORT" }, { "doc_id": 36651210, "sentence_ids": [ 0 ], "label": "SUPPORT" } ]	[ 10546779, 25413327, 36651210 ]
537	Hypocretin neurones suppress panicprone state in rats.	[ { "doc_id": 16056514, "sentence_ids": [ 4 ], "label": "CONTRADICT" } ]	[ 16056514 ]
541	Hypothalamic glutamate neurotransmission is unrelated to energy balance.	[ { "doc_id": 45154987, "sentence_ids": [ 7 ], "label": "CONTRADICT" }, { "doc_id": 45154987, "sentence_ids": [ 8 ], "label": "CONTRADICT" }, { "doc_id": 11886686, "sentence_ids": [ 5 ], "label": "CONTRADICT" } ]	[ 45154987, 11886686, 25007443 ]
542	IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.	[ { "doc_id": 19688024, "sentence_ids": [ 3 ], "label": "CONTRADICT" } ]	[ 19688024 ]
545	IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.	[]	[ 24221369 ]
547	IL-10 production by monocytes inhibits CD4 + T cell response.	[ { "doc_id": 10648422, "sentence_ids": [ 4 ], "label": "SUPPORT" }, { "doc_id": 10648422, "sentence_ids": [ 5 ], "label": "SUPPORT" } ]	[ 10648422 ]
548	IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.	[ { "doc_id": 18199839, "sentence_ids": [ 8, 9 ], "label": "SUPPORT" }, { "doc_id": 18199839, "sentence_ids": [ 11 ], "label": "SUPPORT" } ]	[ 18199839 ]
550	ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).	[]	[ 33499189 ]
553	IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.	[ { "doc_id": 1471041, "sentence_ids": [ 3 ], "label": "CONTRADICT" } ]	[ 1471041 ]
555	Immune complex triggered cell death leads to extracellular release of nuclear DNA.	[]	[ 1049501 ]
557	Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.	[]	[ 1049501 ]
559	Immune responses in immune cells are geographically segregated.	[ { "doc_id": 3475317, "sentence_ids": [ 7 ], "label": "SUPPORT" } ]	[ 3475317 ]
562	Improvements in OER catalysts show stable activity over several hundred hours.	[ { "doc_id": 20101846, "sentence_ids": [ 4 ], "label": "SUPPORT" } ]	[ 20101846 ]
563	In British Men, haplogroup I decreases risk of cardiovascular disease.	[ { "doc_id": 2867345, "sentence_ids": [ 7 ], "label": "CONTRADICT" } ]	[ 2867345 ]
564	In British Men, haplogroup I increases risk of cardiovascular disease by 50%.	[ { "doc_id": 2867345, "sentence_ids": [ 7 ], "label": "SUPPORT" } ]	[ 2867345 ]
565	In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.	[ { "doc_id": 16120395, "sentence_ids": [ 1, 2 ], "label": "SUPPORT" }, { "doc_id": 16120395, "sentence_ids": [ 3 ], "label": "SUPPORT" }, { "doc_id": 16120395, "sentence_ids": [ 4 ], "label": "SUPPORT" } ]	[ 16120395 ]
566	In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.	[ { "doc_id": 16120395, "sentence_ids": [ 1, 2 ], "label": "CONTRADICT" }, { "doc_id": 16120395, "sentence_ids": [ 3 ], "label": "CONTRADICT" }, { "doc_id": 16120395, "sentence_ids": [ 4 ], "label": "CONTRADICT" } ]	[ 16120395 ]
568	In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells.	[ { "doc_id": 23418635, "sentence_ids": [ 5 ], "label": "SUPPORT" }, { "doc_id": 23418635, "sentence_ids": [ 6 ], "label": "SUPPORT" }, { "doc_id": 23418635, "sentence_ids": [ 7 ], "label": "SUPPORT" } ]	[ 23418635 ]
570	In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.	[ { "doc_id": 20333864, "sentence_ids": [ 2 ], "label": "SUPPORT" }, { "doc_id": 20333864, "sentence_ids": [ 3 ], "label": "SUPPORT" } ]	[ 20333864 ]
571	In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.	[ { "doc_id": 20333864, "sentence_ids": [ 2 ], "label": "CONTRADICT" }, { "doc_id": 20333864, "sentence_ids": [ 3 ], "label": "CONTRADICT" } ]	[ 20333864 ]
572	In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs.	[]	[ 4447055 ]
573	In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common.	[]	[ 10300888 ]
574	In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.	[]	[ 10300888 ]
576	In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.	[ { "doc_id": 4468861, "sentence_ids": [ 4 ], "label": "SUPPORT" } ]	[ 4468861 ]
579	In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.	[ { "doc_id": 34139429, "sentence_ids": [ 13 ], "label": "CONTRADICT" } ]	[ 34139429 ]
580	In pediatric tissue, most T cells are naive T cell emigrants from the thymus.	[ { "doc_id": 23460562, "sentence_ids": [ 4 ], "label": "SUPPORT" } ]	[ 23460562 ]
582	In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.	[]	[ 14260013 ]
584	In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.	[ { "doc_id": 14260013, "sentence_ids": [ 9 ], "label": "SUPPORT" } ]	[ 14260013 ]
585	In the UK, drowning affects boys and girls equally.	[]	[ 42291761 ]
588	In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.	[]	[ 16999023 ]
590	In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.	[ { "doc_id": 10984005, "sentence_ids": [ 9, 10 ], "label": "CONTRADICT" }, { "doc_id": 10984005, "sentence_ids": [ 12 ], "label": "CONTRADICT" } ]	[ 10984005 ]
591	Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.	[ { "doc_id": 14682243, "sentence_ids": [ 8 ], "label": "SUPPORT" } ]	[ 14682243 ]
592	Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.	[ { "doc_id": 14682243, "sentence_ids": [ 8 ], "label": "CONTRADICT" } ]	[ 14682243 ]
594	Incidence of heart failure increased by 10% in women since 1979.	[ { "doc_id": 19675911, "sentence_ids": [ 5 ], "label": "CONTRADICT" } ]	[ 19675911 ]
595	Incidence of sepsis has fallen substantially from 2009 to 2014.	[ { "doc_id": 4824840, "sentence_ids": [ 9 ], "label": "CONTRADICT" }, { "doc_id": 4824840, "sentence_ids": [ 13 ], "label": "CONTRADICT" } ]	[ 4824840 ]
600	Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).	[ { "doc_id": 12258338, "sentence_ids": [ 11 ], "label": "CONTRADICT" }, { "doc_id": 12258338, "sentence_ids": [ 14 ], "label": "CONTRADICT" } ]	[ 12258338 ]
601	Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).	[ { "doc_id": 12258338, "sentence_ids": [ 11 ], "label": "SUPPORT" }, { "doc_id": 12258338, "sentence_ids": [ 14 ], "label": "SUPPORT" } ]	[ 12258338 ]
602	Increase of p62 in prostate tumor stroma results in defective autophagy.	[]	[ 3701541 ]
603	Increased LDL receptors plays a role in the reduction of plasma Lp(a).	[ { "doc_id": 6540064, "sentence_ids": [ 9, 10, 11 ], "label": "SUPPORT" }, { "doc_id": 6540064, "sentence_ids": [ 16 ], "label": "SUPPORT" } ]	[ 6540064 ]
606	Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.	[]	[ 712078 ]
607	Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.	[ { "doc_id": 4506414, "sentence_ids": [ 9 ], "label": "SUPPORT" } ]	[ 4506414 ]
609	Increased flux of microbial products provokes immune responses.	[]	[ 40096222 ]
610	Increased flux of microbial products suppresses immune responses.	[]	[ 40096222 ]
611	Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.	[]	[ 32408470 ]
612	Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.	[ { "doc_id": 9638032, "sentence_ids": [ 4 ], "label": "CONTRADICT" } ]	[ 9638032 ]
614	Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.	[ { "doc_id": 9638032, "sentence_ids": [ 4 ], "label": "SUPPORT" }, { "doc_id": 9638032, "sentence_ids": [ 5 ], "label": "SUPPORT" } ]	[ 9638032 ]
615	Increased microtubule acetylation worsens interference of axonal transport caused by LRRK2 Roc-COR domain mutations.	[ { "doc_id": 9638032, "sentence_ids": [ 4 ], "label": "CONTRADICT" }, { "doc_id": 9638032, "sentence_ids": [ 5 ], "label": "CONTRADICT" } ]	[ 9638032 ]
616	Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.	[]	[ 18670 ]
617	Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.	[]	[ 18670 ]
618	Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.	[]	[ 6836086 ]
620	Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.	[]	[ 2565138 ]
621	Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.	[ { "doc_id": 1642727, "sentence_ids": [ 9 ], "label": "SUPPORT" }, { "doc_id": 1642727, "sentence_ids": [ 13 ], "label": "SUPPORT" } ]	[ 1642727 ]
622	Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.	[]	[ 17000834 ]
624	Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.	[ { "doc_id": 20033112, "sentence_ids": [ 3 ], "label": "SUPPORT" }, { "doc_id": 20033112, "sentence_ids": [ 6 ], "label": "SUPPORT" } ]	[ 20033112 ]
625	Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.	[ { "doc_id": 20033112, "sentence_ids": [ 3 ], "label": "SUPPORT" } ]	[ 20033112 ]
626	Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.	[ { "doc_id": 16355392, "sentence_ids": [ 2 ], "label": "SUPPORT" } ]	[ 16355392 ]
631	Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.	[ { "doc_id": 5468807, "sentence_ids": [ 4 ], "label": "SUPPORT" } ]	[ 5468807 ]
632	Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.	[ { "doc_id": 5172048, "sentence_ids": [ 3 ], "label": "CONTRADICT" }, { "doc_id": 5172048, "sentence_ids": [ 5 ], "label": "CONTRADICT" }, { "doc_id": 5172048, "sentence_ids": [ 6 ], "label": "CONTRADICT" }, { "doc_id": 5172048, "sentence_ids": [ 7 ], "label": "CONTRADICT" } ]	[ 5172048 ]
633	Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.	[ { "doc_id": 5172048, "sentence_ids": [ 3 ], "label": "CONTRADICT" }, { "doc_id": 5172048, "sentence_ids": [ 7 ], "label": "CONTRADICT" } ]	[ 5172048 ]
635	Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.	[ { "doc_id": 1686997, "sentence_ids": [ 1, 2 ], "label": "CONTRADICT" } ]	[ 1686997 ]
638	Input from mental and physical health care professionals is not effective at decreasing homelessness.	[]	[ 25649714 ]
640	Inside the body, falciparum parasites reproduce asexually.	[ { "doc_id": 6503185, "sentence_ids": [ 1 ], "label": "SUPPORT" }, { "doc_id": 6503185, "sentence_ids": [ 3 ], "label": "SUPPORT" } ]	[ 6503185 ]
642	Insulin decreases risk of severe kidney failure.	[]	[ 13619127 ]
643	Insulin effects appetite via ventral tegmental neurons.	[ { "doc_id": 15535511, "sentence_ids": [ 3, 5 ], "label": "SUPPORT" } ]	[ 15535511 ]
645	Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.	[ { "doc_id": 12810152, "sentence_ids": [ 0 ], "label": "CONTRADICT" } ]	[ 12810152 ]
646	Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.	[ { "doc_id": 12810152, "sentence_ids": [ 0 ], "label": "SUPPORT" } ]	[ 12810152 ]
647	Integrated care is ineffective at tackling multiple comorbidities.	[ { "doc_id": 15041758, "sentence_ids": [ 6 ], "label": "CONTRADICT" }, { "doc_id": 15041758, "sentence_ids": [ 7 ], "label": "CONTRADICT" }, { "doc_id": 15041758, "sentence_ids": [ 8 ], "label": "CONTRADICT" } ]	[ 15041758 ]
648	Integrated care is successful at tackling multiple comorbidities.	[ { "doc_id": 15041758, "sentence_ids": [ 6 ], "label": "SUPPORT" }, { "doc_id": 15041758, "sentence_ids": [ 7 ], "label": "SUPPORT" }, { "doc_id": 15041758, "sentence_ids": [ 8 ], "label": "SUPPORT" } ]	[ 15041758 ]
650	Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.	[]	[ 12789595 ]
651	Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.	[]	[ 9433958 ]
652	Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.	[]	[ 9433958 ]
653	Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.	[ { "doc_id": 24384587, "sentence_ids": [ 0 ], "label": "SUPPORT" }, { "doc_id": 24384587, "sentence_ids": [ 1 ], "label": "SUPPORT" }, { "doc_id": 24384587, "sentence_ids": [ 5 ], "label": "SUPPORT" } ]	[ 24384587 ]
654	Intra-cerebroventricular infusion of amyloid-β oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.	[]	[ 57574395 ]
655	Intra-cerebroventricular infusion of amyloid-β oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.	[]	[ 57574395 ]
657	Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.	[ { "doc_id": 8533245, "sentence_ids": [ 2, 3 ], "label": "SUPPORT" } ]	[ 8533245 ]
658	It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.	[]	[ 5293024 ]
661	JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.	[ { "doc_id": 37204802, "sentence_ids": [ 3, 4, 6 ], "label": "SUPPORT" } ]	[ 37204802 ]
662	JMJD6 slows the hydroxylation of C-terminal lysine	[ { "doc_id": 37204802, "sentence_ids": [ 3, 4, 6 ], "label": "CONTRADICT" } ]	[ 37204802 ]
663	KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.	[ { "doc_id": 22080671, "sentence_ids": [ 5 ], "label": "SUPPORT" } ]	[ 22080671 ]
665	KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.	[ { "doc_id": 12580014, "sentence_ids": [ 1 ], "label": "SUPPORT" }, { "doc_id": 12580014, "sentence_ids": [ 2 ], "label": "SUPPORT" } ]	[ 12580014 ]
666	Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.	[ { "doc_id": 4469125, "sentence_ids": [ 2 ], "label": "SUPPORT" } ]	[ 4469125 ]
667	Klf2 is important for proper myeloid cell function.	[ { "doc_id": 6493422, "sentence_ids": [ 2 ], "label": "SUPPORT" }, { "doc_id": 6493422, "sentence_ids": [ 4 ], "label": "SUPPORT" }, { "doc_id": 6493422, "sentence_ids": [ 5 ], "label": "SUPPORT" } ]	[ 6493422 ]
668	Klf4 is important for proper myeloid cell differentiation.	[ { "doc_id": 25148216, "sentence_ids": [ 0 ], "label": "SUPPORT" }, { "doc_id": 25148216, "sentence_ids": [ 4 ], "label": "SUPPORT" }, { "doc_id": 25148216, "sentence_ids": [ 5 ], "label": "SUPPORT" }, { "doc_id": 25148216, "sentence_ids": [ 6 ], "label": "SUPPORT" } ]	[ 6493422, 25148216 ]
669	Klf4 is not required for proper myeloid cell differentiation.	[ { "doc_id": 25148216, "sentence_ids": [ 0 ], "label": "CONTRADICT" }, { "doc_id": 25148216, "sentence_ids": [ 4 ], "label": "CONTRADICT" }, { "doc_id": 25148216, "sentence_ids": [ 5 ], "label": "CONTRADICT" }, { "doc_id": 25148216, "sentence_ids": [ 6 ], "label": "CONTRADICT" } ]	[ 6493422, 25148216 ]
670	Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.	[ { "doc_id": 5573975, "sentence_ids": [ 2 ], "label": "SUPPORT" }, { "doc_id": 5573975, "sentence_ids": [ 6 ], "label": "SUPPORT" } ]	[ 5573975 ]
671	Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.	[ { "doc_id": 5573975, "sentence_ids": [ 2 ], "label": "SUPPORT" } ]	[ 5573975 ]
672	L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.	[]	[ 15635366 ]
673	LDL cholesterol has a causal role in the development of cardiovascular disease.	[ { "doc_id": 2095573, "sentence_ids": [ 0 ], "label": "SUPPORT" } ]	[ 2095573 ]
676	LRBA prevents CTLA - 4 recycling.	[]	[ 857189 ]
677	LRBA promotes CTLA - 4 recycling.	[]	[ 857189 ]
679	LSD1-positive promoters are associated with RNA polymerase II	[]	[ 13639330 ]
680	Lack of FGF21 in mice increases life expectancy.	[ { "doc_id": 9315213, "sentence_ids": [ 4 ], "label": "CONTRADICT" } ]	[ 9315213 ]
681	Lack of FGF21 in mice leads to atherosclerotic plaque formation.	[ { "doc_id": 9315213, "sentence_ids": [ 4 ], "label": "SUPPORT" }, { "doc_id": 9315213, "sentence_ids": [ 5 ], "label": "SUPPORT" }, { "doc_id": 9315213, "sentence_ids": [ 8 ], "label": "SUPPORT" } ]	[ 9315213 ]

509

Hematopoietic Stem Cell purification reaches purity rates above 90%.

[]

[ 13980338 ]

515

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).

[ { "doc_id": 29564505, "sentence_ids": [ 8 ], "label": "SUPPORT" }, { "doc_id": 29564505, "sentence_ids": [ 13 ], "label": "SUPPORT" } ]

[ 29564505 ]

523

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.

[ { "doc_id": 14803797, "sentence_ids": [ 1 ], "label": "CONTRADICT" }, { "doc_id": 14803797, "sentence_ids": [ 5 ], "label": "CONTRADICT" } ]

[ 14803797 ]

524

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.

[ { "doc_id": 14803797, "sentence_ids": [ 1 ], "label": "SUPPORT" }, { "doc_id": 14803797, "sentence_ids": [ 5 ], "label": "SUPPORT" } ]

[ 14803797 ]

526

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.

[]

[ 3863543 ]

529

Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

[ { "doc_id": 10546779, "sentence_ids": [ 2 ], "label": "SUPPORT" }, { "doc_id": 25413327, "sentence_ids": [ 0 ], "label": "SUPPORT" }, { "doc_id": 25413327, "sentence_ids": [ 5 ], "label": "SUPPORT" }, { "doc_id": 36651210, "sentence_ids": [ 0 ], "label": "SUPPORT" } ]

[ 10546779, 25413327, 36651210 ]

530

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

[ { "doc_id": 10546779, "sentence_ids": [ 2 ], "label": "CONTRADICT" }, { "doc_id": 25413327, "sentence_ids": [ 0 ], "label": "CONTRADICT" }, { "doc_id": 25413327, "sentence_ids": [ 5 ], "label": "CONTRADICT" }, { "doc_id": 36651210, "sentence_ids": [ 0 ], "label": "CONTRADICT" } ]

[ 10546779, 25413327, 36651210, 87610599 ]

531

Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

[ { "doc_id": 10546779, "sentence_ids": [ 2 ], "label": "SUPPORT" }, { "doc_id": 25413327, "sentence_ids": [ 0 ], "label": "SUPPORT" }, { "doc_id": 36651210, "sentence_ids": [ 0 ], "label": "SUPPORT" } ]

[ 10546779, 25413327, 36651210 ]

537

Hypocretin neurones suppress panicprone state in rats.

[ { "doc_id": 16056514, "sentence_ids": [ 4 ], "label": "CONTRADICT" } ]

[ 16056514 ]

541

Hypothalamic glutamate neurotransmission is unrelated to energy balance.

[ { "doc_id": 45154987, "sentence_ids": [ 7 ], "label": "CONTRADICT" }, { "doc_id": 45154987, "sentence_ids": [ 8 ], "label": "CONTRADICT" }, { "doc_id": 11886686, "sentence_ids": [ 5 ], "label": "CONTRADICT" } ]

[ 45154987, 11886686, 25007443 ]

542

IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.

[ { "doc_id": 19688024, "sentence_ids": [ 3 ], "label": "CONTRADICT" } ]

[ 19688024 ]

545

IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.

[]

[ 24221369 ]

547

IL-10 production by monocytes inhibits CD4 + T cell response.

[ { "doc_id": 10648422, "sentence_ids": [ 4 ], "label": "SUPPORT" }, { "doc_id": 10648422, "sentence_ids": [ 5 ], "label": "SUPPORT" } ]

[ 10648422 ]

548

IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.

[ { "doc_id": 18199839, "sentence_ids": [ 8, 9 ], "label": "SUPPORT" }, { "doc_id": 18199839, "sentence_ids": [ 11 ], "label": "SUPPORT" } ]

[ 18199839 ]

550

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

[]

[ 33499189 ]

553

IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.

[ { "doc_id": 1471041, "sentence_ids": [ 3 ], "label": "CONTRADICT" } ]

[ 1471041 ]

555

Immune complex triggered cell death leads to extracellular release of nuclear DNA.

[]

[ 1049501 ]

557

Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.

[]

[ 1049501 ]

559

Immune responses in immune cells are geographically segregated.

[ { "doc_id": 3475317, "sentence_ids": [ 7 ], "label": "SUPPORT" } ]

[ 3475317 ]

562

Improvements in OER catalysts show stable activity over several hundred hours.

[ { "doc_id": 20101846, "sentence_ids": [ 4 ], "label": "SUPPORT" } ]

[ 20101846 ]

563

In British Men, haplogroup I decreases risk of cardiovascular disease.

[ { "doc_id": 2867345, "sentence_ids": [ 7 ], "label": "CONTRADICT" } ]

[ 2867345 ]

564

In British Men, haplogroup I increases risk of cardiovascular disease by 50%.

[ { "doc_id": 2867345, "sentence_ids": [ 7 ], "label": "SUPPORT" } ]

[ 2867345 ]

565

In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.

[ { "doc_id": 16120395, "sentence_ids": [ 1, 2 ], "label": "SUPPORT" }, { "doc_id": 16120395, "sentence_ids": [ 3 ], "label": "SUPPORT" }, { "doc_id": 16120395, "sentence_ids": [ 4 ], "label": "SUPPORT" } ]

[ 16120395 ]

566

In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.

[ { "doc_id": 16120395, "sentence_ids": [ 1, 2 ], "label": "CONTRADICT" }, { "doc_id": 16120395, "sentence_ids": [ 3 ], "label": "CONTRADICT" }, { "doc_id": 16120395, "sentence_ids": [ 4 ], "label": "CONTRADICT" } ]

[ 16120395 ]

568

In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells.

[ { "doc_id": 23418635, "sentence_ids": [ 5 ], "label": "SUPPORT" }, { "doc_id": 23418635, "sentence_ids": [ 6 ], "label": "SUPPORT" }, { "doc_id": 23418635, "sentence_ids": [ 7 ], "label": "SUPPORT" } ]

[ 23418635 ]

570

In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.

[ { "doc_id": 20333864, "sentence_ids": [ 2 ], "label": "SUPPORT" }, { "doc_id": 20333864, "sentence_ids": [ 3 ], "label": "SUPPORT" } ]

[ 20333864 ]

571

In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.

[ { "doc_id": 20333864, "sentence_ids": [ 2 ], "label": "CONTRADICT" }, { "doc_id": 20333864, "sentence_ids": [ 3 ], "label": "CONTRADICT" } ]

[ 20333864 ]

572

In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs.

[]

[ 4447055 ]

573

In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common.

[]

[ 10300888 ]

574

In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.

[]

[ 10300888 ]

576

In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.

[ { "doc_id": 4468861, "sentence_ids": [ 4 ], "label": "SUPPORT" } ]

[ 4468861 ]

579

In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.

[ { "doc_id": 34139429, "sentence_ids": [ 13 ], "label": "CONTRADICT" } ]

[ 34139429 ]

580

In pediatric tissue, most T cells are naive T cell emigrants from the thymus.

[ { "doc_id": 23460562, "sentence_ids": [ 4 ], "label": "SUPPORT" } ]

[ 23460562 ]

582

In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.

[]

[ 14260013 ]

584

In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.

[ { "doc_id": 14260013, "sentence_ids": [ 9 ], "label": "SUPPORT" } ]

[ 14260013 ]

585

In the UK, drowning affects boys and girls equally.

[]

[ 42291761 ]

588

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.

[]

[ 16999023 ]

590

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

[ { "doc_id": 10984005, "sentence_ids": [ 9, 10 ], "label": "CONTRADICT" }, { "doc_id": 10984005, "sentence_ids": [ 12 ], "label": "CONTRADICT" } ]

[ 10984005 ]

591

Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.

[ { "doc_id": 14682243, "sentence_ids": [ 8 ], "label": "SUPPORT" } ]

[ 14682243 ]

592

Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.

[ { "doc_id": 14682243, "sentence_ids": [ 8 ], "label": "CONTRADICT" } ]

[ 14682243 ]

594

Incidence of heart failure increased by 10% in women since 1979.

[ { "doc_id": 19675911, "sentence_ids": [ 5 ], "label": "CONTRADICT" } ]

[ 19675911 ]

595

Incidence of sepsis has fallen substantially from 2009 to 2014.

[ { "doc_id": 4824840, "sentence_ids": [ 9 ], "label": "CONTRADICT" }, { "doc_id": 4824840, "sentence_ids": [ 13 ], "label": "CONTRADICT" } ]

[ 4824840 ]

600

Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).

[ { "doc_id": 12258338, "sentence_ids": [ 11 ], "label": "CONTRADICT" }, { "doc_id": 12258338, "sentence_ids": [ 14 ], "label": "CONTRADICT" } ]

[ 12258338 ]

601

Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).

[ { "doc_id": 12258338, "sentence_ids": [ 11 ], "label": "SUPPORT" }, { "doc_id": 12258338, "sentence_ids": [ 14 ], "label": "SUPPORT" } ]

[ 12258338 ]

602

Increase of p62 in prostate tumor stroma results in defective autophagy.

[]

[ 3701541 ]

603

Increased LDL receptors plays a role in the reduction of plasma Lp(a).

[ { "doc_id": 6540064, "sentence_ids": [ 9, 10, 11 ], "label": "SUPPORT" }, { "doc_id": 6540064, "sentence_ids": [ 16 ], "label": "SUPPORT" } ]

[ 6540064 ]

606

Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

[]

[ 712078 ]

607

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

[ { "doc_id": 4506414, "sentence_ids": [ 9 ], "label": "SUPPORT" } ]

[ 4506414 ]

609

Increased flux of microbial products provokes immune responses.

[]

[ 40096222 ]

610

Increased flux of microbial products suppresses immune responses.

[]

[ 40096222 ]

611

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

[]

[ 32408470 ]

612

Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.

[ { "doc_id": 9638032, "sentence_ids": [ 4 ], "label": "CONTRADICT" } ]

[ 9638032 ]

614

Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.

[ { "doc_id": 9638032, "sentence_ids": [ 4 ], "label": "SUPPORT" }, { "doc_id": 9638032, "sentence_ids": [ 5 ], "label": "SUPPORT" } ]

[ 9638032 ]

615

Increased microtubule acetylation worsens interference of axonal transport caused by LRRK2 Roc-COR domain mutations.

[ { "doc_id": 9638032, "sentence_ids": [ 4 ], "label": "CONTRADICT" }, { "doc_id": 9638032, "sentence_ids": [ 5 ], "label": "CONTRADICT" } ]

[ 9638032 ]

616

Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.

[]

[ 18670 ]

617

Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.

[]

[ 18670 ]

618

Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.

[]

[ 6836086 ]

620

Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.

[]

[ 2565138 ]

621

Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.

[ { "doc_id": 1642727, "sentence_ids": [ 9 ], "label": "SUPPORT" }, { "doc_id": 1642727, "sentence_ids": [ 13 ], "label": "SUPPORT" } ]

[ 1642727 ]

622

Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.

[]

[ 17000834 ]

624

Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.

[ { "doc_id": 20033112, "sentence_ids": [ 3 ], "label": "SUPPORT" }, { "doc_id": 20033112, "sentence_ids": [ 6 ], "label": "SUPPORT" } ]

[ 20033112 ]

625

Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.

[ { "doc_id": 20033112, "sentence_ids": [ 3 ], "label": "SUPPORT" } ]

[ 20033112 ]

626

Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.

[ { "doc_id": 16355392, "sentence_ids": [ 2 ], "label": "SUPPORT" } ]

[ 16355392 ]

631

Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.

[ { "doc_id": 5468807, "sentence_ids": [ 4 ], "label": "SUPPORT" } ]

[ 5468807 ]

632

Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.

[ { "doc_id": 5172048, "sentence_ids": [ 3 ], "label": "CONTRADICT" }, { "doc_id": 5172048, "sentence_ids": [ 5 ], "label": "CONTRADICT" }, { "doc_id": 5172048, "sentence_ids": [ 6 ], "label": "CONTRADICT" }, { "doc_id": 5172048, "sentence_ids": [ 7 ], "label": "CONTRADICT" } ]

[ 5172048 ]

633

Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.

[ { "doc_id": 5172048, "sentence_ids": [ 3 ], "label": "CONTRADICT" }, { "doc_id": 5172048, "sentence_ids": [ 7 ], "label": "CONTRADICT" } ]

[ 5172048 ]

635

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

[ { "doc_id": 1686997, "sentence_ids": [ 1, 2 ], "label": "CONTRADICT" } ]

[ 1686997 ]

638

Input from mental and physical health care professionals is not effective at decreasing homelessness.

[]

[ 25649714 ]

640

Inside the body, falciparum parasites reproduce asexually.

[ { "doc_id": 6503185, "sentence_ids": [ 1 ], "label": "SUPPORT" }, { "doc_id": 6503185, "sentence_ids": [ 3 ], "label": "SUPPORT" } ]

[ 6503185 ]

642

Insulin decreases risk of severe kidney failure.

[]

[ 13619127 ]

643

Insulin effects appetite via ventral tegmental neurons.

[ { "doc_id": 15535511, "sentence_ids": [ 3, 5 ], "label": "SUPPORT" } ]

[ 15535511 ]

645

Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.

[ { "doc_id": 12810152, "sentence_ids": [ 0 ], "label": "CONTRADICT" } ]

[ 12810152 ]

646

Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.

[ { "doc_id": 12810152, "sentence_ids": [ 0 ], "label": "SUPPORT" } ]

[ 12810152 ]

647

Integrated care is ineffective at tackling multiple comorbidities.

[ { "doc_id": 15041758, "sentence_ids": [ 6 ], "label": "CONTRADICT" }, { "doc_id": 15041758, "sentence_ids": [ 7 ], "label": "CONTRADICT" }, { "doc_id": 15041758, "sentence_ids": [ 8 ], "label": "CONTRADICT" } ]

[ 15041758 ]

648

Integrated care is successful at tackling multiple comorbidities.

[ { "doc_id": 15041758, "sentence_ids": [ 6 ], "label": "SUPPORT" }, { "doc_id": 15041758, "sentence_ids": [ 7 ], "label": "SUPPORT" }, { "doc_id": 15041758, "sentence_ids": [ 8 ], "label": "SUPPORT" } ]

[ 15041758 ]

650

Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.

[]

[ 12789595 ]

651

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.

[]

[ 9433958 ]

652

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

[]

[ 9433958 ]

653

Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.

[ { "doc_id": 24384587, "sentence_ids": [ 0 ], "label": "SUPPORT" }, { "doc_id": 24384587, "sentence_ids": [ 1 ], "label": "SUPPORT" }, { "doc_id": 24384587, "sentence_ids": [ 5 ], "label": "SUPPORT" } ]

[ 24384587 ]

654

Intra-cerebroventricular infusion of amyloid-β oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

[]

[ 57574395 ]

655

Intra-cerebroventricular infusion of amyloid-β oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

[]

[ 57574395 ]

657

Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

[ { "doc_id": 8533245, "sentence_ids": [ 2, 3 ], "label": "SUPPORT" } ]

[ 8533245 ]

658

It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.

[]

[ 5293024 ]

661

JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.

[ { "doc_id": 37204802, "sentence_ids": [ 3, 4, 6 ], "label": "SUPPORT" } ]

[ 37204802 ]

662

JMJD6 slows the hydroxylation of C-terminal lysine

[ { "doc_id": 37204802, "sentence_ids": [ 3, 4, 6 ], "label": "CONTRADICT" } ]

[ 37204802 ]

663

KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.

[ { "doc_id": 22080671, "sentence_ids": [ 5 ], "label": "SUPPORT" } ]

[ 22080671 ]

665

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.

[ { "doc_id": 12580014, "sentence_ids": [ 1 ], "label": "SUPPORT" }, { "doc_id": 12580014, "sentence_ids": [ 2 ], "label": "SUPPORT" } ]

[ 12580014 ]

666

Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.

[ { "doc_id": 4469125, "sentence_ids": [ 2 ], "label": "SUPPORT" } ]

[ 4469125 ]

667

Klf2 is important for proper myeloid cell function.

[ { "doc_id": 6493422, "sentence_ids": [ 2 ], "label": "SUPPORT" }, { "doc_id": 6493422, "sentence_ids": [ 4 ], "label": "SUPPORT" }, { "doc_id": 6493422, "sentence_ids": [ 5 ], "label": "SUPPORT" } ]

[ 6493422 ]

668

Klf4 is important for proper myeloid cell differentiation.

[ { "doc_id": 25148216, "sentence_ids": [ 0 ], "label": "SUPPORT" }, { "doc_id": 25148216, "sentence_ids": [ 4 ], "label": "SUPPORT" }, { "doc_id": 25148216, "sentence_ids": [ 5 ], "label": "SUPPORT" }, { "doc_id": 25148216, "sentence_ids": [ 6 ], "label": "SUPPORT" } ]

[ 6493422, 25148216 ]

669

Klf4 is not required for proper myeloid cell differentiation.

[ { "doc_id": 25148216, "sentence_ids": [ 0 ], "label": "CONTRADICT" }, { "doc_id": 25148216, "sentence_ids": [ 4 ], "label": "CONTRADICT" }, { "doc_id": 25148216, "sentence_ids": [ 5 ], "label": "CONTRADICT" }, { "doc_id": 25148216, "sentence_ids": [ 6 ], "label": "CONTRADICT" } ]

[ 6493422, 25148216 ]

670

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.

[ { "doc_id": 5573975, "sentence_ids": [ 2 ], "label": "SUPPORT" }, { "doc_id": 5573975, "sentence_ids": [ 6 ], "label": "SUPPORT" } ]

[ 5573975 ]

671

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

[ { "doc_id": 5573975, "sentence_ids": [ 2 ], "label": "SUPPORT" } ]

[ 5573975 ]

672

L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.

[]

[ 15635366 ]

673

LDL cholesterol has a causal role in the development of cardiovascular disease.

[ { "doc_id": 2095573, "sentence_ids": [ 0 ], "label": "SUPPORT" } ]

[ 2095573 ]

676

LRBA prevents CTLA - 4 recycling.

[]

[ 857189 ]

677

LRBA promotes CTLA - 4 recycling.

[]

[ 857189 ]

679

LSD1-positive promoters are associated with RNA polymerase II

[]

[ 13639330 ]

680

Lack of FGF21 in mice increases life expectancy.

[ { "doc_id": 9315213, "sentence_ids": [ 4 ], "label": "CONTRADICT" } ]

[ 9315213 ]

681

Lack of FGF21 in mice leads to atherosclerotic plaque formation.

[ { "doc_id": 9315213, "sentence_ids": [ 4 ], "label": "SUPPORT" }, { "doc_id": 9315213, "sentence_ids": [ 5 ], "label": "SUPPORT" }, { "doc_id": 9315213, "sentence_ids": [ 8 ], "label": "SUPPORT" } ]

[ 9315213 ]