Datasets:

celikmus

/

mayo_clinic_symptoms_and_diseases_v1

like 10

The first symptoms of hoarding disorder often appear during the teenage to early adult years. You may get and save too many items, gradually build up clutter in living spaces, and have difficulty getting rid of things. As you grow older, you may continue getting and holding onto things that you may never use and don't have space for. By middle age, the clutter can become overwhelming as symptoms become more severe and increasingly difficult to treat. Problems with hoarding gradually develop over time and tend to be a private behavior. You may avoid having family, friends or repair workers in your home. Often, major clutter has developed by the time it reaches the attention of others. Symptoms of hoarding disorder may include: Getting and keeping too many items that you may not have a need for right now and don't have space for. Ongoing difficulty throwing out or parting with your things, regardless of their actual value. Feeling a need to save these items and being upset by the thought of getting rid of them. Building up clutter to the point where you can't use rooms. Trying to be perfect and avoiding or delaying decisions. Problems with planning and organizing. Getting too many items and refusing to part with them results in: Disorganized piles or stacks of items, such as newspapers, clothes, paperwork, books or sentimental items. Items that crowd and clutter your walking spaces and living areas. Rooms can't be used for the intended purpose, such as not being able to sleep in your bed. Buildup of food or trash to large, unsanitary levels. Distress or problems functioning or keeping yourself, others and pets safe in your home. Conflict with others who try to reduce or remove clutter from your home. Relationship issues, avoiding social activities and employment problems. Difficulty organizing items and sometimes losing important items in the clutter. With hoarding disorder, items are usually saved because: You believe these items are unique or that you'll need them at some point in the future. You feel emotionally connected to items that remind you of happier times or represent beloved people or pets. You feel safe and comforted when surrounded by things. You don't want to waste anything. Hoarding disorder is different from collecting. People who have collections, such as stamps or model cars, carefully search out specific items, organize them and display their collections. Collections can be large, but they aren't usually cluttered. Also, they don't cause the distress and problems functioning that are part of hoarding disorder. Hoarding animals People who hoard animals may collect dozens or even hundreds of pets. Animals may be confined inside or outside. Because of the large numbers, these animals often aren't cared for properly. The health and safety of the person and the animals are often at risk because of unsanitary conditions.

hoarding-disorder

The main symptom of infertility is the inability to get pregnant. A menstrual cycle that's too long (35 days or more), too short (less than 21 days), irregular or absent can mean that you're not ovulating. There might be no other signs or symptoms.

female-infertility

Symptoms of antisocial personality disorder include repeatedly: Ignoring right and wrong. Telling lies to take advantage of others. Not being sensitive to or respectful of others. Using charm or wit to manipulate others for personal gain or pleasure. Having a sense of superiority and being extremely opinionated. Having problems with the law, including criminal behavior. Being hostile, aggressive, violent or threatening to others. Feeling no guilt about harming others. Doing dangerous things with no regard for the safety of self or others. Being irresponsible and failing to fulfill work or financial responsibilities. Adults with antisocial personality disorder usually show symptoms of conduct disorder before the age of 15. Symptoms of conduct disorder include serious, ongoing behavior problems, such as: Aggression toward people and animals. Destruction of property. Lying and dishonesty. Theft. Serious violation of rules. Antisocial personality disorder is considered a lifelong condition. But in some people, certain symptoms ― particularly destructive and criminal behavior ― may decrease over time. It's not clear whether this decrease is a result of the effect aging has on their mind and body, an increased awareness of the impact that antisocial behavior has had on their life, or other factors.

antisocial-personality-disorder

The signs and symptoms of cavities vary, depending on their extent and location. When a cavity is just beginning, you may not have any symptoms at all. As the decay gets larger, it may cause signs and symptoms such as: Toothache, spontaneous pain or pain that occurs without any apparent cause Tooth sensitivity Mild to sharp pain when eating or drinking something sweet, hot or cold Visible holes or pits in your teeth Brown, black or white staining on any surface of a tooth Pain when you bite down When to see a dentist You may not be aware that a cavity is forming. That's why it's important to have regular dental checkups and cleanings, even when your mouth feels fine. However, if you experience a toothache or mouth pain, see your dentist as soon as possible.

cavities

If a baby is born with pulmonary atresia, symptoms will be noticeable soon after birth. Signs and symptoms might include: Blue- or gray-toned skin (cyanosis) Fast breathing or shortness of breath Easily tiring or being fatigued Feeding problems

pulmonary-atresia

Signs and symptoms of a brain tumor in children vary greatly and depend on the brain tumor type, size, location and rate of growth. Some signs and symptoms may not be easy to detect because they're similar to symptoms of other conditions. Some of the more common symptoms of a brain tumor in children include: Headaches, which may become more frequent and more severe Feeling of increased pressure in the head Unexplained nausea or vomiting Abrupt onset of vision problems, such double vision Other possible signs and symptoms, depending on the tumor location, include: A fuller soft spot (fontanel) on the skull in babies Seizures, especially when there's no history of seizures Abnormal eye movement Slurred speech Trouble swallowing Loss of appetite; or in babies, difficulty feeding Difficulty with balance Trouble walking Weakness or loss of sensation in an arm or a leg Weakness or drooping on one side on the face Confusion, irritability Memory problems Personality or behavior changes Hearing problems

pediatric-brain-tumor

Signs and symptoms of a sprained ankle vary depending on the severity of the injury. They may include: Pain, especially when you bear weight on the affected foot Tenderness when you touch the ankle Swelling Bruising Restricted range of motion Instability in the ankle Popping sensation or sound at the time of injury

sprained-ankle

Signs and symptoms of dry socket may include: Severe pain within a few days after a tooth extraction Partial or total loss of the blood clot at the tooth extraction site, which you may notice as an empty-looking (dry) socket Visible bone in the socket Pain that radiates from the socket to your ear, eye, temple or neck on the same side of your face as the extraction Bad breath or a foul odor coming from your mouth Unpleasant taste in your mouth When to see a doctor A certain degree of pain and discomfort is normal after a tooth extraction. However, you should be able to manage normal pain with the pain reliever prescribed by your dentist or oral surgeon, and the pain should lessen with time. If you develop new or worsening pain in the days after your tooth extraction, contact your dentist or oral surgeon immediately.

dry-socket

Mumps Open pop-up dialog box Close Mumps Mumps A common symptom of mumps is painful swelling on one or both sides of the face. Mumps Open pop-up dialog box Mumps Open pop-up dialog box Open pop-up dialog box Close Mumps Mumps A common symptom of mumps is painful swelling on one or both sides of the face. Close Mumps Mumps A common symptom of mumps is painful swelling on one or both sides of the face. Close Mumps Mumps A common symptom of mumps is painful swelling on one or both sides of the face. Close Close Close Mumps Mumps A common symptom of mumps is painful swelling on one or both sides of the face. Mumps A common symptom of mumps is painful swelling on one or both sides of the face. A common symptom of mumps is painful swelling on one or both sides of the face. Symptoms of mumps show up about 2 to 3 weeks after exposure to the virus. Some people may have no symptoms or very mild symptoms. The first symptoms may be similar to flu symptoms such as: Fever. Headache. Muscle aches or pain. Not wanting to eat. Tiredness. Swelling of the salivary glands usually starts within a few days. Symptoms may include: Swelling of one or both glands on the sides of the face. Pain or tenderness around the swelling. Less often, swelling of glands below the floor of the mouth.

mumps

Often the only sign of a hydrocele is a painless swelling of one or both testicles. The swelling might make an adult's scrotum feel heavy. In general, pain gets worse as the swelling increases. Sometimes, the swollen area might be smaller in the morning and larger later in the day.

hydrocele

Symptoms of delirium usually begin over a few hours or a few days. They typically occur with a medical problem. Symptoms often come and go during the day. There may be periods of no symptoms. Symptoms tend to be worse at night when it's dark and things look less familiar. They also tend to be worse in settings that aren't familiar, such as in a hospital. Primary symptoms include the following. Reduced awareness of surroundings This may result in: Trouble focusing on a topic or changing topics Getting stuck on an idea rather than responding to questions Being easily distracted Being withdrawn, with little or no activity or little response to surroundings Poor thinking skills This may appear as: Poor memory, such as forgetting recent events Not knowing where they are or who they are Trouble with speech or recalling words Rambling or nonsense speech Trouble understanding speech Trouble reading or writing Behavior and emotional changes These may include: Anxiety, fear or distrust of others Depression A short temper or anger A sense of feeling elated Lack of interest and emotion Quick changes in mood Personality changes Seeing things that others don't see Being restless, anxious or combative Calling out, moaning or making other sounds Being quiet and withdrawn — especially in older adults Slowed movement or being sluggish Changes in sleep habits A switched night-day sleep-wake cycle Types of delirium Experts have identified three types: Hyperactive delirium. This may be the easiest type to recognize. People with this type may be restless and pace the room. They also may be anxious, have rapid mood swings or see things that aren't there. People with this type often resist care. Hypoactive delirium. People with this type may be inactive or have reduced activity. They tend to be sluggish or drowsy. They might seem to be in a daze. They don't interact with family or others. Mixed delirium. Symptoms involve both types of delirium. The person may quickly switch back and forth from being restless and sluggish. Delirium and dementia Delirium and dementia may be hard to tell apart, and a person may have both. Someone with dementia has a gradual decline of memory and other thinking skills due to damage or loss of brain cells. The most common cause of dementia is Alzheimer's disease, which comes on slowly over months or years. Delirium often occurs in people with dementia. However, episodes of delirium don't always mean a person has dementia. Tests for dementia shouldn't be done during a delirium episode because the results could be misleading. Some differences between the symptoms of delirium and dementia include: Onset. The onset of delirium occurs within a short time — within a day or two. Dementia usually begins with minor symptoms that get worse over time. Attention. The ability to stay focused or maintain focus is impaired with delirium. A person in the early stages of dementia remains generally alert. Someone with dementia often isn't sluggish or agitated. Rapid changes in symptoms. Delirium symptoms can come and go several times during the day. While people with dementia have better and worse times of day, their memory and thinking skills typically stay at a constant level.

delirium

Autoimmune pancreatitis (AIP) is difficult to diagnose. Often, it doesn't cause any symptoms. Symptoms and signs of type 1 AIP are similar to those of pancreatic cancer. AIP Pancreatic cancer signs and symptoms can include: Dark urine Pale stools or stools that float in the toilet Yellow skin and eyes (jaundice) Pain in your upper abdomen or middle part of your back Nausea and vomiting Weakness or extreme tiredness Loss of appetite or feelings of fullness Weight loss for no known reason The most common sign of type 1 AIP, present in about 80% of people, is painless jaundice, caused by blocked bile ducts. Type 2 AIP can present with recurrent episodes of acute pancreatitis. Pain in the upper abdomen, a common symptom of pancreatic cancer, is frequently absent in autoimmune pancreatitis. AIP AIP Differences between type 1 and type 2 AIP are: AIP In type 1 AIP, the disease may affect other organs in addition to the pancreas. Type 2 AIP affects only the pancreas, although the disease is associated with another autoimmune condition, inflammatory bowel disease. Type 1 AIP predominantly affects men in the sixth to seventh decade of life. Type 2 AIP affects both men and women equally and has a younger age of onset compared with type 1 AIP. Type 1 AIP is more likely to relapse after treatment is discontinued.

autoimmune-pancreatitis

Peyronie's disease signs and symptoms might appear suddenly or develop gradually. The most common signs and symptoms include: Scar tissue. The scar tissue associated with Peyronie's disease — called plaque but different from plaque that can build up in blood vessels — can be felt under the skin of the penis as flat lumps or a band of hard tissue. A significant bend to the penis. Your penis might curve upward or downward or bend to one side. Erection problems. Peyronie's disease might cause problems getting or maintaining an erection (erectile dysfunction). But, often men report erectile dysfunction before the beginning of Peyronie's disease symptoms. Shortening of the penis. Your penis might become shorter as a result of Peyronie's disease. Pain. You might have penile pain, with or without an erection. Other penile deformity. In some men with Peyronie's disease, the erect penis might have narrowing, indentations or even an hourglass-like appearance, with a tight, narrow band around the shaft. The curvature and penile shortening associated with Peyronie's disease might gradually worsen. At some point, however, the condition typically stabilizes after three to 12 months or so. Pain during erections usually improves within one to two years, but the scar tissue, penile shortening and curvature often remain. In some men, both the curvature and pain associated with Peyronie's disease improve without treatment.

peyronies-disease

Signs and symptoms of malaria may include: Fever Chills General feeling of discomfort Headache Nausea and vomiting Diarrhea Abdominal pain Muscle or joint pain Fatigue Rapid breathing Rapid heart rate Cough Some people who have malaria experience cycles of malaria "attacks." An attack usually starts with shivering and chills, followed by a high fever, followed by sweating and a return to normal temperature. Malaria signs and symptoms typically begin within a few weeks after being bitten by an infected mosquito. However, some types of malaria parasites can lie dormant in your body for up to a year.

malaria

There are no specific symptoms that indicate a conjoined twin pregnancy. As with other twin pregnancies, the uterus may grow faster than it does with a single baby. And there may be more tiredness, nausea and vomiting early in the pregnancy. Conjoined twins can be diagnosed early in the pregnancy using an ultrasound. How twins are joined Conjoined twins are usually classified according to where they're joined. The twins sometimes share organs or other parts of their bodies. Each pair of conjoined twins is unique. Conjoined twins may be joined at any of these sites: Chest. Thoracopagus (thor-uh-KOP-uh-gus) twins are joined face to face at the chest. They often have a shared heart and may also share one liver and upper intestine. This is one of the most common sites of conjoined twins. Abdomen. Omphalopagus (om-fuh-LOP-uh-gus) twins are joined near the bellybutton. Many omphalopagus twins share the liver and some part of the upper digestive (gastrointestinal or GI) tract. Some twins share the lower part of the small intestine (ileum) and the longest part of the large intestine (colon). They generally do not share a heart. Base of spine. Pygopagus (pie-GOP-uh-gus) twins are commonly joined back to back at the base of the spine and the buttocks. Some pygopagus twins share the lower gastrointestinal (GI) tract. A few twins share the genital and urinary organs. Length of spine. Rachipagus (ray-KIP-uh-gus), also called rachiopagus (ray-kee-OP-uh-gus), twins are joined back to back along the length of the spine. This type is very rare. Pelvis. Ischiopagus (is-kee-OP-uh-gus) twins are joined at the pelvis, either face to face or end to end. Many ischiopagus twins share the lower GI tract, as well as the liver and genital and urinary tract organs. Each twin may have two legs or, less commonly, the twins share two or three legs. Trunk. Parapagus (pa-RAP-uh-gus) twins are joined side to side at the pelvis and part or all of the belly (abdomen) and chest, but with separate heads. The twins can have two, three or four arms and two or three legs. Head. Craniopagus (kray-nee-OP-uh-gus) twins are joined at the back, top or side of the head, but not the face. Craniopagus twins share a portion of the skull. But their brains are usually separate, though they may share some brain tissue. Head and chest. Cephalopagus (sef-uh-LOP-uh-gus) twins are joined at the head and upper body. The faces are on opposite sides of a single shared head, and they share a brain. These twins rarely survive. In rare cases, twins may be conjoined with one twin smaller and less fully formed than the other (asymmetric conjoined twins). In extremely rare cases, one twin may be found partially developed within the other twin (fetus in fetu).

conjoined-twins

Common symptoms of hemifacial spasm include twitching or contracting of muscles in the face that are usually: On one side of the face Uncontrollable Painless These contractions often start in the eyelid, then may progress and affect the cheek and mouth on the same side of the face. At first, hemifacial spasms come and go. But eventually, usually over the course of several months to a few years, they occur almost constantly. Occasionally, hemifacial spasms may occur on both sides of the face. However, the twitching doesn't occur on both sides of the face at the same time. Causes Hemifacial spasm is most often caused by a blood vessel touching a facial nerve. It can also be caused by a facial nerve injury or a tumor. Sometimes there's no identifiable cause. Hemifacial spasm may sometimes be triggered by: Moving the muscles in the face Anxiety Stress Fatigue By Mayo Clinic Staff By Mayo Clinic Staff Hemifacial spasm care at Mayo Clinic

hemifacial-spasm

Tuberous sclerosis symptoms are caused by noncancerous growths in parts of the body, most commonly in the skin, brain, eyes, kidneys, heart and lungs. But any part of the body can be affected. Symptoms can range from mild to severe, depending on the size or location of the growths. Although symptoms are different for each person with tuberous sclerosis, they can include: Skin changes. Skin changes are most common. These include patches of lighter skin and small areas of thickened, smooth or bumpy skin. On the forehead, skin can have raised, discolored areas. Small soft bumps under or around the nails may occur. Growths on the face that start in childhood and look like acne are common. Seizures. Growths in the brain may be linked with seizures. A seizure is often the first symptom of tuberous sclerosis. In small children, a common type of seizure called infantile spasm involves stiffening of the arms and legs and arching the back and head. Problems in thinking, reasoning and learning. Tuberous sclerosis can result in developmental delays. Sometimes it limits the ability to think, reason and learn. Mental health conditions, such as autism spectrum disorder or attention-deficit/hyperactivity disorder (ADHD), also can occur. Behavior problems. Common behavior problems may include hyperactivity, self-injury or aggression, or issues with social and emotional adjustment. Kidney problems. Growths on the kidneys are common, and more growths may develop with age. Heart issues. Growths in the heart, if present, are usually largest at birth and shrink as a child gets older. Lung problems. Growths that develop in the lungs may cause coughing or trouble breathing, especially with physical activity or exercise. These lung tumors occur more often in females than in males. Eye problems. Growths can appear as white patches on the light-sensitive tissue at the back of the eye called the retina. These growths usually don't interfere with vision. Dental changes. Teeth may have pits in the surface. Small growths may appear on the gums, inside of the cheeks and on the tongue.

tuberous-sclerosis

Spider veins Open pop-up dialog box Close Spider veins Spider veins Spider veins appear as thin, red lines or as weblike networks of blood vessels on the surface of the skin. Spider veins, a mild form of varicose veins, typically appear on the legs and feet. Spider veins Open pop-up dialog box Spider veins Open pop-up dialog box Open pop-up dialog box Close Spider veins Spider veins Spider veins appear as thin, red lines or as weblike networks of blood vessels on the surface of the skin. Spider veins, a mild form of varicose veins, typically appear on the legs and feet. Close Spider veins Spider veins Spider veins appear as thin, red lines or as weblike networks of blood vessels on the surface of the skin. Spider veins, a mild form of varicose veins, typically appear on the legs and feet. Close Spider veins Spider veins Spider veins appear as thin, red lines or as weblike networks of blood vessels on the surface of the skin. Spider veins, a mild form of varicose veins, typically appear on the legs and feet. Close Close Close Spider veins Spider veins Spider veins appear as thin, red lines or as weblike networks of blood vessels on the surface of the skin. Spider veins, a mild form of varicose veins, typically appear on the legs and feet. Spider veins Spider veins appear as thin, red lines or as weblike networks of blood vessels on the surface of the skin. Spider veins, a mild form of varicose veins, typically appear on the legs and feet. Spider veins appear as thin, red lines or as weblike networks of blood vessels on the surface of the skin. Spider veins, a mild form of varicose veins, typically appear on the legs and feet. Varicose veins might not cause pain. Signs of varicose veins include: Veins that are dark purple or blue Veins that appear twisted and bulging, often appearing like cords on the legs When painful signs and symptoms of varicose veins occur, they might include: An achy or heavy feeling in the legs Burning, throbbing, muscle cramping and swelling in the lower legs Worsened pain after sitting or standing for a long time Itching around one or more of the veins Changes in skin color around a varicose vein Spider veins are similar to varicose veins, but they're smaller. Spider veins are found closer to the skin's surface and are often red or blue. Spider veins occur on the legs but can also be found on the face. They vary in size and often look like a spider's web.

varicose-veins

Signs and symptoms of body dysmorphic disorder include: Being extremely preoccupied with a perceived flaw in appearance that to others can't be seen or appears minor Strong belief that you have a defect in your appearance that makes you ugly or deformed Belief that others take special notice of your appearance in a negative way or mock you Engaging in behaviors aimed at fixing or hiding the perceived flaw that are difficult to resist or control, such as frequently checking the mirror, grooming or skin picking Attempting to hide perceived flaws with styling, makeup or clothes Constantly comparing your appearance with others Frequently seeking reassurance about your appearance from others Having perfectionist tendencies Seeking cosmetic procedures with little satisfaction Avoiding social situations Preoccupation with your appearance and excessive thoughts and repetitive behaviors can be unwanted, difficult to control and so time-consuming that they can cause major distress or problems in your social life, work, school or other areas of functioning. You may excessively focus over one or more parts of your body. The bodily feature that you focus on may change over time. The most common features people tend to fixate about include: Face, such as nose, complexion, wrinkles, acne and other blemishes Hair, such as appearance, thinning and baldness Skin and vein appearance Breast size Muscle size and tone Genitalia A preoccupation with your body build being too small or not muscular enough (muscle dysmorphia) occurs almost exclusively in males. Insight about body dysmorphic disorder varies. You may recognize that your beliefs about your perceived flaws may be excessive or not be true, or think that they probably are true, or be absolutely convinced that they're true. The more convinced you are of your beliefs, the more distress and disruption you may experience in your life.

body-dysmorphic-disorder

Osteoarthritis of the hip Open pop-up dialog box Close Osteoarthritis of the hip Osteoarthritis of the hip The hip joint shown on the left side of the image is normal, but the hip joint shown on the right side of the image shows deterioration of cartilage and the formation of bone spurs due to osteoarthritis. Osteoarthritis of the hip Open pop-up dialog box Osteoarthritis of the hip Open pop-up dialog box Open pop-up dialog box Close Osteoarthritis of the hip Osteoarthritis of the hip The hip joint shown on the left side of the image is normal, but the hip joint shown on the right side of the image shows deterioration of cartilage and the formation of bone spurs due to osteoarthritis. Close Osteoarthritis of the hip Osteoarthritis of the hip The hip joint shown on the left side of the image is normal, but the hip joint shown on the right side of the image shows deterioration of cartilage and the formation of bone spurs due to osteoarthritis. Close Osteoarthritis of the hip Osteoarthritis of the hip The hip joint shown on the left side of the image is normal, but the hip joint shown on the right side of the image shows deterioration of cartilage and the formation of bone spurs due to osteoarthritis. Close Close Close Osteoarthritis of the hip Osteoarthritis of the hip The hip joint shown on the left side of the image is normal, but the hip joint shown on the right side of the image shows deterioration of cartilage and the formation of bone spurs due to osteoarthritis. Osteoarthritis of the hip The hip joint shown on the left side of the image is normal, but the hip joint shown on the right side of the image shows deterioration of cartilage and the formation of bone spurs due to osteoarthritis. The hip joint shown on the left side of the image is normal, but the hip joint shown on the right side of the image shows deterioration of cartilage and the formation of bone spurs due to osteoarthritis. Bone spurs on spine Open pop-up dialog box Close Bone spurs on spine Bone spurs on spine In osteoarthritis of the spine, disks narrow and bone spurs form. Bone spurs on spine Open pop-up dialog box Bone spurs on spine Open pop-up dialog box Open pop-up dialog box Close Bone spurs on spine Bone spurs on spine In osteoarthritis of the spine, disks narrow and bone spurs form. Close Bone spurs on spine Bone spurs on spine In osteoarthritis of the spine, disks narrow and bone spurs form. Close Bone spurs on spine Bone spurs on spine In osteoarthritis of the spine, disks narrow and bone spurs form. Close Close Close Bone spurs on spine Bone spurs on spine In osteoarthritis of the spine, disks narrow and bone spurs form. Bone spurs on spine In osteoarthritis of the spine, disks narrow and bone spurs form. In osteoarthritis of the spine, disks narrow and bone spurs form. Most bone spurs cause no signs or symptoms. You might not realize you have bone spurs until an X-ray for another condition reveals the growths. In some cases, though, bone spurs can cause pain and loss of motion in your joints. Specific symptoms depend on where the bone spurs are. Examples include: Knee. Bone spurs in your knee can make it painful to extend and bend your leg. Spine. On your vertebrae, bone spurs can narrow the space that contains your spinal cord. These bone spurs can pinch the spinal cord or its nerve roots and can cause weakness or numbness in your arms or legs. Hip. Bone spurs can make it painful to move your hip, although you might feel the pain in your knee. Depending on their placement, bone spurs can reduce the range of motion in your hip joint.

bone-spurs

Signs and symptoms of an ACL injury usually include: ACL A loud pop or a "popping" sensation in the knee Severe pain and inability to continue activity Rapid swelling Loss of range of motion A feeling of instability or "giving way" with weight bearing

acl-injury

Symptoms of anal itching may include intense itching, inflammation, burning and soreness. The itching and irritation may be short lived or more persistent, depending on the cause. Anal itching often is worse at bedtime or in hot, humid weather.

anal-itching

The signs and symptoms of diverticulitis include: Pain, which may be constant and persist for several days. The lower left side of the abdomen is the usual site of the pain. Sometimes, however, the right side of the abdomen is more painful, especially in people of Asian descent. Nausea and vomiting. Fever. Abdominal tenderness. Constipation or, less commonly, diarrhea.

diverticulitis

Warning signs of bedsores or pressure ulcers are: Unusual changes in skin color or texture Swelling Pus-like draining An area of skin that feels cooler or warmer to the touch than other areas Tender areas Bedsores fall into one of several stages based on their depth, severity and other characteristics. The degree of skin and tissue damage ranges from changes in skin color to a deep injury involving muscle and bone. Common sites of pressure ulcers For people who use wheelchairs, bedsores often occur on skin over the following sites: Tailbone or buttocks Shoulder blades and spine Backs of arms and legs where they rest against the chair For people who need to stay in bed, bedsores may happen on: The back or sides of the head The shoulder blades The hip, lower back or tailbone The heels, ankles and skin behind the knees

bed-sores

Pityriasis rosea typically begins with an oval, slightly raised, scaly patch — called the herald patch — on the face, back, chest or abdomen. Before the herald patch appears, some people have headache, fatigue, fever or sore throat. A few days to a few weeks after the herald patch appears, you may notice smaller bumps or scaly spots across your face, back, chest or abdomen that look like a pine-tree pattern. The rash can cause itching.

pityriasis-rosea

Symptoms of acute hepatitis B range from mild to severe. They usually appear about 1 to 4 months after you've been infected, although you could see them as early as two weeks after you're infected. Some people, usually young children, may not have any symptoms. Hepatitis B signs and symptoms may include: Abdominal pain Dark urine Fever Joint pain Loss of appetite Nausea and vomiting Weakness and fatigue Yellowing of the skin and the whites of the eyes, also called jaundice

hepatitis-b

Thirst isn't always a reliable early indicator of the body's need for water. Many people, particularly older adults, don't feel thirsty until they're already dehydrated. That's why it's important to increase water intake during hot weather or when you're ill. The signs and symptoms of dehydration also may differ by age. Infant or young child Dry mouth and tongue No tears when crying No wet diapers for three hours Sunken eyes, cheeks Sunken soft spot on top of skull Listlessness or irritability Adult Extreme thirst Less frequent urination Dark-colored urine Fatigue Dizziness Confusion When to see a doctor Call your family doctor if you or a loved one: Has had diarrhea for 24 hours or more Is irritable or disoriented and much sleepier or less active than usual Can't keep down fluids Has bloody or black stool

dehydration

Bone marrow Open pop-up dialog box Close Bone marrow Bone marrow Bone marrow is a red, spongy material inside your bones that produces blood cells. Bone marrow Open pop-up dialog box Bone marrow Open pop-up dialog box Open pop-up dialog box Close Bone marrow Bone marrow Bone marrow is a red, spongy material inside your bones that produces blood cells. Close Bone marrow Bone marrow Bone marrow is a red, spongy material inside your bones that produces blood cells. Close Bone marrow Bone marrow Bone marrow is a red, spongy material inside your bones that produces blood cells. Close Close Close Bone marrow Bone marrow Bone marrow is a red, spongy material inside your bones that produces blood cells. Bone marrow Bone marrow is a red, spongy material inside your bones that produces blood cells. Bone marrow is a red, spongy material inside your bones that produces blood cells. Aplastic anemia can have no symptoms. When present, signs and symptoms can include: Fatigue Shortness of breath Rapid or irregular heart rate Pale skin Frequent or prolonged infections Unexplained or easy bruising Nosebleeds and bleeding gums Prolonged bleeding from cuts Skin rash Dizziness Headache Fever Aplastic anemia can be short-lived, or it can become chronic. It can be severe and even fatal.

aplastic-anemia

Prostate cancer may cause no signs or symptoms in its early stages. Prostate cancer that's more advanced may cause signs and symptoms such as: Trouble urinating Decreased force in the stream of urine Blood in the urine Blood in the semen Bone pain Losing weight without trying Erectile dysfunction

prostate-cancer

Adults and children who have familial hypercholesterolemia have very high levels of low-density lipoprotein (LDL) cholesterol in their blood. LDL cholesterol is known as "bad" cholesterol because it can build up in the walls of the arteries, making them hard and narrow. LDL This excess cholesterol is sometimes deposited in certain portions of the skin, some tendons and around the iris of the eyes: Skin. The most common spots for cholesterol deposits to occur is on the hands, elbows and knees. They also can occur in the skin around the eyes. Tendons. Cholesterol deposits may thicken the Achilles tendon, along with some tendons in the hands. Eyes. High cholesterol levels can cause corneal arcus, a white or gray ring around the iris of the eye. This happens most commonly in older people, but it can occur in younger people who have familial hypercholesterolemia. Causes Familial hypercholesterolemia is caused by a gene alteration that's passed down from one or both parents. People who have this condition are born with it. This change prevents the body from ridding itself of the type of cholesterol that can build up in the arteries and cause heart disease. Risk factors The risk of familial hypercholesterolemia is higher if one or both of your parents have the gene alteration that causes it. Most people who have the condition receive one affected gene. But in rare cases, a child can get the affected gene from both parents. This can cause a more severe form of the condition. Familial hypercholesterolemia may be more common in certain populations, including: Ashkenazi Jews Some Lebanese groups French Canadians Complications People who have familial hypercholesterolemia have a higher risk of heart disease and death at a younger age. Heart attacks may occur before age 50 in men and age 60 in women. The rarer and more severe variety of the condition, if undiagnosed or untreated, can cause death before age 20. By Mayo Clinic Staff By Mayo Clinic Staff Request an appointment Request an appointment Diagnosis & treatment Diagnosis & treatment Diagnosis & treatment Sept. 23, 2021 Print Print Share on: FacebookTwitter Facebook Twitter Show references Kliegman RM, et al. Defects in metabolism of lipids. In: Nelson Textbook of Pediatrics. 21st ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed July 15, 2021. Goldman L, et al., eds. Disorders of lipid metabolism. In: Goldman-Cecil Medicine. 26th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed July 15, 2021. Familial hypercholesterolemia. Centers for Disease Control and Prevention. https://www.cdc.gov/genomics/disease/fh/FH.htm. Accessed July 15, 2021. Inheriting issues with cholesterol. American Heart Association. https://www.heart.org/en/health-topics/cholesterol/causes-of-high-cholesterol/familial-hypercholesterolemia-fh. Accessed July 15, 2021. AskMayoExpert. Familial hypercholesterolemia. Mayo Clinic; 2020. Rosenson RS, et al. Familial hypercholesterolemia in adults: Overview. https://www.uptodate.com/contents/search. Accessed July 15, 2021. De Ferranti SD. Familial hypercholesterolemia in children. https://www.uptodate.com/contents/search. Accessed July 15, 2021. Blood cholesterol. National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health-topics/blood-cholesterol. Accessed July 15, 2021. Rosenson RS, et al. Familial hypercholesterolemia in adults: Treatment. https://www.uptodate.com/contents/search. Accessed July 15, 2021. Show references Kliegman RM, et al. Defects in metabolism of lipids. In: Nelson Textbook of Pediatrics. 21st ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed July 15, 2021. Goldman L, et al., eds. Disorders of lipid metabolism. In: Goldman-Cecil Medicine. 26th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed July 15, 2021. Familial hypercholesterolemia. Centers for Disease Control and Prevention. https://www.cdc.gov/genomics/disease/fh/FH.htm. Accessed July 15, 2021. Inheriting issues with cholesterol. American Heart Association. https://www.heart.org/en/health-topics/cholesterol/causes-of-high-cholesterol/familial-hypercholesterolemia-fh. Accessed July 15, 2021. AskMayoExpert. Familial hypercholesterolemia. Mayo Clinic; 2020. Rosenson RS, et al. Familial hypercholesterolemia in adults: Overview. https://www.uptodate.com/contents/search. Accessed July 15, 2021. De Ferranti SD. Familial hypercholesterolemia in children. https://www.uptodate.com/contents/search. Accessed July 15, 2021. Blood cholesterol. National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health-topics/blood-cholesterol. Accessed July 15, 2021. Rosenson RS, et al. Familial hypercholesterolemia in adults: Treatment. https://www.uptodate.com/contents/search. Accessed July 15, 2021. Kliegman RM, et al. Defects in metabolism of lipids. In: Nelson Textbook of Pediatrics. 21st ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed July 15, 2021. Goldman L, et al., eds. Disorders of lipid metabolism. In: Goldman-Cecil Medicine. 26th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed July 15, 2021. Familial hypercholesterolemia. Centers for Disease Control and Prevention. https://www.cdc.gov/genomics/disease/fh/FH.htm. Accessed July 15, 2021. Inheriting issues with cholesterol. American Heart Association. https://www.heart.org/en/health-topics/cholesterol/causes-of-high-cholesterol/familial-hypercholesterolemia-fh. Accessed July 15, 2021. AskMayoExpert. Familial hypercholesterolemia. Mayo Clinic; 2020. Rosenson RS, et al. Familial hypercholesterolemia in adults: Overview. https://www.uptodate.com/contents/search. Accessed July 15, 2021. De Ferranti SD. Familial hypercholesterolemia in children. https://www.uptodate.com/contents/search. Accessed July 15, 2021. Blood cholesterol. National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health-topics/blood-cholesterol. Accessed July 15, 2021. Rosenson RS, et al. Familial hypercholesterolemia in adults: Treatment. https://www.uptodate.com/contents/search. Accessed July 15, 2021. Kliegman RM, et al. Defects in metabolism of lipids. In: Nelson Textbook of Pediatrics. 21st ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed July 15, 2021. Goldman L, et al., eds. Disorders of lipid metabolism. In: Goldman-Cecil Medicine. 26th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed July 15, 2021. Familial hypercholesterolemia. Centers for Disease Control and Prevention. https://www.cdc.gov/genomics/disease/fh/FH.htm. Accessed July 15, 2021. Inheriting issues with cholesterol. American Heart Association. https://www.heart.org/en/health-topics/cholesterol/causes-of-high-cholesterol/familial-hypercholesterolemia-fh. Accessed July 15, 2021. AskMayoExpert. Familial hypercholesterolemia. Mayo Clinic; 2020. Rosenson RS, et al. Familial hypercholesterolemia in adults: Overview. https://www.uptodate.com/contents/search. Accessed July 15, 2021. De Ferranti SD. Familial hypercholesterolemia in children. https://www.uptodate.com/contents/search. Accessed July 15, 2021. Blood cholesterol. National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health-topics/blood-cholesterol. Accessed July 15, 2021. Rosenson RS, et al. Familial hypercholesterolemia in adults: Treatment. https://www.uptodate.com/contents/search. Accessed July 15, 2021. Familial hypercholesterolemiaSymptoms & causesDiagnosis & treatmentDoctors & departments Familial hypercholesterolemia Symptoms & causesDiagnosis & treatmentDoctors & departments

familial-hypercholesterolemia

Enlarged thyroid Open pop-up dialog box Close Enlarged thyroid Enlarged thyroid Widespread enlargement of the thyroid can expand the gland well beyond its typical size (left) and cause a noticeable bulge in the neck (right). Enlarged thyroid Open pop-up dialog box Enlarged thyroid Open pop-up dialog box Open pop-up dialog box Close Enlarged thyroid Enlarged thyroid Widespread enlargement of the thyroid can expand the gland well beyond its typical size (left) and cause a noticeable bulge in the neck (right). Close Enlarged thyroid Enlarged thyroid Widespread enlargement of the thyroid can expand the gland well beyond its typical size (left) and cause a noticeable bulge in the neck (right). Close Enlarged thyroid Enlarged thyroid Widespread enlargement of the thyroid can expand the gland well beyond its typical size (left) and cause a noticeable bulge in the neck (right). Close Close Close Enlarged thyroid Enlarged thyroid Widespread enlargement of the thyroid can expand the gland well beyond its typical size (left) and cause a noticeable bulge in the neck (right). Enlarged thyroid Widespread enlargement of the thyroid can expand the gland well beyond its typical size (left) and cause a noticeable bulge in the neck (right). Widespread enlargement of the thyroid can expand the gland well beyond its typical size (left) and cause a noticeable bulge in the neck (right). Common signs and symptoms of Graves' disease include: Anxiety and irritability A fine tremor of the hands or fingers Heat sensitivity and an increase in perspiration or warm, moist skin Weight loss, despite normal eating habits Enlargement of the thyroid gland (goiter) Change in menstrual cycles Erectile dysfunction or reduced libido Frequent bowel movements Bulging eyes (Graves' ophthalmopathy) Fatigue Thick, red skin usually on the shins or tops of the feet (Graves' dermopathy) Rapid or irregular heartbeat (palpitations) Sleep disturbance Graves' ophthalmopathy Graves' ophthalmopathy Open pop-up dialog box Close Graves' ophthalmopathy Graves' ophthalmopathy Graves' ophthalmopathy signs and symptoms include bulging eyes, redness and retracting eyelids. Graves' ophthalmopathy Open pop-up dialog box Graves' ophthalmopathy Open pop-up dialog box Open pop-up dialog box Close Graves' ophthalmopathy Graves' ophthalmopathy Graves' ophthalmopathy signs and symptoms include bulging eyes, redness and retracting eyelids. Close Graves' ophthalmopathy Graves' ophthalmopathy Graves' ophthalmopathy signs and symptoms include bulging eyes, redness and retracting eyelids. Close Graves' ophthalmopathy Graves' ophthalmopathy Graves' ophthalmopathy signs and symptoms include bulging eyes, redness and retracting eyelids. Close Close Close Graves' ophthalmopathy Graves' ophthalmopathy Graves' ophthalmopathy signs and symptoms include bulging eyes, redness and retracting eyelids. Graves' ophthalmopathy Graves' ophthalmopathy signs and symptoms include bulging eyes, redness and retracting eyelids. Graves' ophthalmopathy signs and symptoms include bulging eyes, redness and retracting eyelids. About 30% of people with Graves' disease show some signs and symptoms of Graves' ophthalmopathy. In Graves' ophthalmopathy, inflammation and other immune system events affect muscles and other tissues around your eyes. Signs and symptoms may include: Bulging eyes Gritty sensation in the eyes Pressure or pain in the eyes Puffy or retracted eyelids Reddened or inflamed eyes Light sensitivity Double vision Vision loss Graves' dermopathy Graves' dermopathy Open pop-up dialog box Close Graves' dermopathy Graves' dermopathy Rarely, people who have Graves' disease develop a reddish thickening of the skin that resembles the texture of an orange peel (Graves' dermopathy). This results from a buildup of protein in the skin. It often occurs on the shins and on the tops of the feet. Graves' dermopathy Open pop-up dialog box Graves' dermopathy Open pop-up dialog box Open pop-up dialog box Close Graves' dermopathy Graves' dermopathy Rarely, people who have Graves' disease develop a reddish thickening of the skin that resembles the texture of an orange peel (Graves' dermopathy). This results from a buildup of protein in the skin. It often occurs on the shins and on the tops of the feet. Close Graves' dermopathy Graves' dermopathy Rarely, people who have Graves' disease develop a reddish thickening of the skin that resembles the texture of an orange peel (Graves' dermopathy). This results from a buildup of protein in the skin. It often occurs on the shins and on the tops of the feet. Close Graves' dermopathy Graves' dermopathy Rarely, people who have Graves' disease develop a reddish thickening of the skin that resembles the texture of an orange peel (Graves' dermopathy). This results from a buildup of protein in the skin. It often occurs on the shins and on the tops of the feet. Close Close Close Graves' dermopathy Graves' dermopathy Rarely, people who have Graves' disease develop a reddish thickening of the skin that resembles the texture of an orange peel (Graves' dermopathy). This results from a buildup of protein in the skin. It often occurs on the shins and on the tops of the feet. Graves' dermopathy Rarely, people who have Graves' disease develop a reddish thickening of the skin that resembles the texture of an orange peel (Graves' dermopathy). This results from a buildup of protein in the skin. It often occurs on the shins and on the tops of the feet. Rarely, people who have Graves' disease develop a reddish thickening of the skin that resembles the texture of an orange peel (Graves' dermopathy). This results from a buildup of protein in the skin. It often occurs on the shins and on the tops of the feet. An uncommon manifestation of Graves' disease, called Graves' dermopathy, is the reddening and thickening of the skin, most often on your shins or the tops of your feet.

graves-disease

Petechiae Open pop-up dialog box Close Petechiae Petechiae Petechiae may look like a rash and usually appear in clusters. Here they appear on a leg (A) and on an abdomen (B). Petechiae Open pop-up dialog box Petechiae Open pop-up dialog box Open pop-up dialog box Close Petechiae Petechiae Petechiae may look like a rash and usually appear in clusters. Here they appear on a leg (A) and on an abdomen (B). Close Petechiae Petechiae Petechiae may look like a rash and usually appear in clusters. Here they appear on a leg (A) and on an abdomen (B). Close Petechiae Petechiae Petechiae may look like a rash and usually appear in clusters. Here they appear on a leg (A) and on an abdomen (B). Close Close Close Petechiae Petechiae Petechiae may look like a rash and usually appear in clusters. Here they appear on a leg (A) and on an abdomen (B). Petechiae Petechiae may look like a rash and usually appear in clusters. Here they appear on a leg (A) and on an abdomen (B). Petechiae may look like a rash and usually appear in clusters. Here they appear on a leg (A) and on an abdomen (B). Immune thrombocytopenia may have no signs and symptoms. When they do occur, they may include: Easy or excessive bruising Superficial bleeding into the skin that appears as pinpoint-sized reddish-purple spots (petechiae) that look like a rash, usually on the lower legs Bleeding from the gums or nose Blood in urine or stools Unusually heavy menstrual flow

idiopathic-thrombocytopenic-purpura

Symptoms of ischemic colitis can include: Pain, tenderness or cramping in your belly, which can occur suddenly or happen over time Bright red or maroon blood in your stool or, at times, passage of blood alone without stool A feeling of urgency to move your bowels Diarrhea Nausea The risk of severe complications is higher when you have symptoms on the right side of your belly. This is less commonly seen compared with left-sided colitis. People with right-sided colitis tend to have more underlying medical problems, such as high blood pressure, atrial fibrillation and kidney disease. They more frequently have to undergo surgery and also have a higher risk of death.

ischemic-colitis

A broken wrist might cause these signs and symptoms: Severe pain that might worsen when gripping or squeezing or moving your hand or wrist Swelling Tenderness Bruising Obvious deformity, such as a bent wrist When to call a doctor If you think you might have a broken wrist, see a doctor immediately, especially if you have numbness, swelling or trouble moving your fingers. A delay in diagnosis and treatment can lead to poor healing, decreased range of motion and decreased grip strength.

broken-wrist

Type 2 diabetes in children may develop so gradually that there are no noticeable symptoms. Sometimes, the disorder is diagnosed during a routine check-up. Some children might experience these signs and symptoms as a result of too much sugar in their bloodstreams: Increased thirst Frequent urination Increased hunger Fatigue Blurry vision Darkened areas of skin, most often around the neck or in the armpits and groin Unintended weight loss, although this is less common in children with type 2 diabetes than in children with type 1 diabetes Frequent infections

type-2-diabetes-in-children

Elevated blood pressure doesn't cause symptoms. The only way to detect it is to have regular blood pressure checks. Have your blood pressure measured when you visit your health care provider. You can also check it at home with a home blood pressure monitoring device.

prehypertension

Harmless (innocent) heart murmurs usually don't cause any other symptoms. Symptoms of worrisome heart murmurs depend on the cause. Heart murmur symptoms may include: Blue or gray fingernails or lips Chest pain Cough that doesn't go away Dizziness Swollen liver Swollen neck veins Fainting Heavy sweating with little or no activity In infants, poor appetite and lack of growth Shortness of breath Swelling or sudden weight gain

heart-murmurs

In the months or years leading up to menopause (perimenopause), you might experience these signs and symptoms: Irregular periods Vaginal dryness Hot flashes Chills Night sweats Sleep problems Mood changes Weight gain and slowed metabolism Thinning hair and dry skin Loss of breast fullness Signs and symptoms, including changes in menstruation can vary among women. Most likely, you'll experience some irregularity in your periods before they end. Skipping periods during perimenopause is common and expected. Often, menstrual periods will skip a month and return, or skip several months and then start monthly cycles again for a few months. Periods also tend to happen on shorter cycles, so they are closer together. Despite irregular periods, pregnancy is possible. If you've skipped a period but aren't sure you've started the menopausal transition, consider a pregnancy test.

menopause

Multiple system atrophy (MSA) affects many parts of your body. Symptoms usually start in adulthood, usually in the 50s or 60s. There are two types of MSA: parkinsonian and cerebellar. The type depends on the symptoms you have when you're diagnosed. MSA Parkinsonian type This is the most common type of MSA. The signs and symptoms are similar to those of Parkinson's disease, such as: MSA Stiff muscles Difficulty bending your arms and legs Slow movement (bradykinesia) Tremors can occur at rest or when moving your arms or legs Soft voice Problems with posture and balance Cerebellar type The main signs and symptoms are problems with muscle coordination (ataxia), but others may include: Impaired movement and coordination, such as unsteady gait and loss of balance Slurred, slow or low-volume speech (dysarthria) Visual disturbances, such as blurred or double vision and difficulty focusing your eyes Difficulty swallowing (dysphagia) or chewing Changes in speech, such as slurred speech General signs and symptoms In addition, the primary sign of multiple system atrophy is autonomic failure, which may cause problems with body functions you can't control. This may include: Postural (orthostatic) hypotension Postural hypotension is a form of low blood pressure that makes you feel dizzy or lightheaded, or even faint, when you stand up from sitting or lying down. Not everyone with MSA has postural hypotension. MSA You can also develop dangerously high blood pressure levels while lying down (supine hypertension). Urinary and bowel dysfunction Constipation Loss of bladder or bowel control (incontinence) Changes in sweat production Producing less sweat Heat intolerance due to reduced sweating Impaired body temperature control, often causing cold hands or feet Sleep disorders Agitated sleep due to "acting out" dreams Abnormal breathing at night or a harsh breathing sound (stridor) Sexual dysfunction Inability to achieve or maintain an erection (impotence) Loss of libido Cardiovascular problems Color changes in hands and feet caused by pooling of blood Psychiatric problems Difficulty controlling emotions, such as laughing or crying inappropriately

multiple-system-atrophy

Signs and symptoms of Charcot-Marie-Tooth disease may include: Weakness in your legs, ankles and feet Loss of muscle bulk in your legs and feet High foot arches Curled toes (hammertoes) Decreased ability to run Difficulty lifting your foot at the ankle (footdrop) Awkward or higher than normal step (gait) Frequent tripping or falling Decreased sensation or a loss of feeling in your legs and feet As Charcot-Marie-Tooth disease progresses, symptoms may spread from the feet and legs to the hands and arms. The severity of symptoms can vary greatly from person to person, even among family members. Causes Charcot-Marie-Tooth disease is an inherited, genetic condition. It occurs when there are mutations in the genes that affect the nerves in your feet, legs, hands and arms. Sometimes, these mutations damage the nerves. Other mutations damage the protective coating that surrounds the nerve (myelin sheath). Both cause weaker messages to travel between your limbs and brain. Risk factors Charcot-Marie-Tooth disease is hereditary, so you're at higher risk of developing the disorder if anyone in your immediate family has the disease. Other causes of neuropathies, such as diabetes, may cause symptoms similar to Charcot-Marie-Tooth disease. These other conditions can also cause the symptoms of Charcot-Marie-Tooth disease to become worse. Medications such as the chemotherapy drugs vincristine (Marqibo), paclitaxel (Abraxane) and others can make symptoms worse. Be sure to let your doctor know about all of the medications you're taking. Complications Complications of Charcot-Marie-Tooth disease vary in severity from person to person. Foot abnormalities and difficulty walking are usually the most serious problems. Muscles may get weaker, and you may injure areas of the body that experience decreased sensation. Sometimes the muscles in your feet may not receive your brain's signal to contract, so you're more likely to trip and fall. And your brain may not receive pain messages from your feet, so if you've rubbed a blister on your toe, for example, it may get infected without your realizing it. You may also experience difficulty breathing, swallowing or speaking if the muscles that control these functions are affected by Charcot-Marie-Tooth disease. By Mayo Clinic Staff By Mayo Clinic Staff Request an appointment Request an appointment Diagnosis & treatment Diagnosis & treatment Diagnosis & treatment March 08, 2023 Print Print Share on: FacebookTwitter Facebook Twitter Show references Klein CJ. Charcot-Marie-Tooth disease and other hereditary neuropathies. Continuum. 2020; doi:10.1212/CON.0000000000000927. Charcot-Marie-Tooth disease fact sheet. National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Charcot-Marie-Tooth-Disease-Fact-Sheet. Accessed Dec. 31, 2020. Kang PB. Charcot-Marie-Tooth disease: Genetics, clinical features and diagnosis. https://www.uptodate.com/contents/search. Accessed Dec. 31, 2020. Facts about Charcot-Marie-Tooth disease and related diseases. Muscular Dystrophy Association. https://www.mda.org/disease/charcot-marie-tooth. Accessed Dec. 31, 2020. Neurotoxic medications. Charcot-Marie-Tooth Association. https://www.cmtausa.org/living-with-cmt/managing-cmt/medications/. Accessed Dec. 31, 2020. Simon RP, et al. Sensory disorders. In: Clinical Neurology. 10th ed. McGraw-Hill; 2018. https://accessmedicine.mhmedical.com. Accessed Dec. 31, 2020. Kang PB. Charcot-Marie-Tooth disease: Management and prognosis. https://www.uptodate.com/contents/search. Accessed Dec. 31, 2020. Rossor AM, et al. Are we prepared for clinical trials in Charcot-Marie-Tooth disease? Brain Research. 2020; doi:10.1016/j.brainres.2019.146625. Pareyson D, et al. New developments in Charcot-Marie-Tooth neuropathy and related diseases. Current Opinion in Neurology. 2017; doi:10.1097/WCO. 0000000000000474. Important foot care for people with CMT. Charcot-Marie-Tooth Association. https://www.cmtausa.org/living-with-cmt/managing-cmt/important-foot-care-for-people-with-cmt/. Accessed Dec. 31, 2020. Pedicure pointers. American Podiatric Medical Association. https://www.apma.org/Patients/HealthyFeetTips.cfm?ItemNumber=9859. Accessed Dec. 31, 2020. Show references Klein CJ. Charcot-Marie-Tooth disease and other hereditary neuropathies. Continuum. 2020; doi:10.1212/CON.0000000000000927. Charcot-Marie-Tooth disease fact sheet. National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Charcot-Marie-Tooth-Disease-Fact-Sheet. Accessed Dec. 31, 2020. Kang PB. Charcot-Marie-Tooth disease: Genetics, clinical features and diagnosis. https://www.uptodate.com/contents/search. Accessed Dec. 31, 2020. Facts about Charcot-Marie-Tooth disease and related diseases. Muscular Dystrophy Association. https://www.mda.org/disease/charcot-marie-tooth. Accessed Dec. 31, 2020. Neurotoxic medications. Charcot-Marie-Tooth Association. https://www.cmtausa.org/living-with-cmt/managing-cmt/medications/. Accessed Dec. 31, 2020. Simon RP, et al. Sensory disorders. In: Clinical Neurology. 10th ed. McGraw-Hill; 2018. https://accessmedicine.mhmedical.com. Accessed Dec. 31, 2020. Kang PB. Charcot-Marie-Tooth disease: Management and prognosis. https://www.uptodate.com/contents/search. Accessed Dec. 31, 2020. Rossor AM, et al. Are we prepared for clinical trials in Charcot-Marie-Tooth disease? Brain Research. 2020; doi:10.1016/j.brainres.2019.146625. Pareyson D, et al. New developments in Charcot-Marie-Tooth neuropathy and related diseases. Current Opinion in Neurology. 2017; doi:10.1097/WCO. 0000000000000474. Important foot care for people with CMT. Charcot-Marie-Tooth Association. https://www.cmtausa.org/living-with-cmt/managing-cmt/important-foot-care-for-people-with-cmt/. Accessed Dec. 31, 2020. Pedicure pointers. American Podiatric Medical Association. https://www.apma.org/Patients/HealthyFeetTips.cfm?ItemNumber=9859. Accessed Dec. 31, 2020. Klein CJ. Charcot-Marie-Tooth disease and other hereditary neuropathies. Continuum. 2020; doi:10.1212/CON.0000000000000927. Charcot-Marie-Tooth disease fact sheet. National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Charcot-Marie-Tooth-Disease-Fact-Sheet. Accessed Dec. 31, 2020. Kang PB. Charcot-Marie-Tooth disease: Genetics, clinical features and diagnosis. https://www.uptodate.com/contents/search. Accessed Dec. 31, 2020. Facts about Charcot-Marie-Tooth disease and related diseases. Muscular Dystrophy Association. https://www.mda.org/disease/charcot-marie-tooth. Accessed Dec. 31, 2020. Neurotoxic medications. Charcot-Marie-Tooth Association. https://www.cmtausa.org/living-with-cmt/managing-cmt/medications/. Accessed Dec. 31, 2020. Simon RP, et al. Sensory disorders. In: Clinical Neurology. 10th ed. McGraw-Hill; 2018. https://accessmedicine.mhmedical.com. Accessed Dec. 31, 2020. Kang PB. Charcot-Marie-Tooth disease: Management and prognosis. https://www.uptodate.com/contents/search. Accessed Dec. 31, 2020. Rossor AM, et al. Are we prepared for clinical trials in Charcot-Marie-Tooth disease? Brain Research. 2020; doi:10.1016/j.brainres.2019.146625. Pareyson D, et al. New developments in Charcot-Marie-Tooth neuropathy and related diseases. Current Opinion in Neurology. 2017; doi:10.1097/WCO. 0000000000000474. Important foot care for people with CMT. Charcot-Marie-Tooth Association. https://www.cmtausa.org/living-with-cmt/managing-cmt/important-foot-care-for-people-with-cmt/. Accessed Dec. 31, 2020. Pedicure pointers. American Podiatric Medical Association. https://www.apma.org/Patients/HealthyFeetTips.cfm?ItemNumber=9859. Accessed Dec. 31, 2020. Klein CJ. Charcot-Marie-Tooth disease and other hereditary neuropathies. Continuum. 2020; doi:10.1212/CON.0000000000000927. Charcot-Marie-Tooth disease fact sheet. National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Charcot-Marie-Tooth-Disease-Fact-Sheet. Accessed Dec. 31, 2020. Kang PB. Charcot-Marie-Tooth disease: Genetics, clinical features and diagnosis. https://www.uptodate.com/contents/search. Accessed Dec. 31, 2020. Facts about Charcot-Marie-Tooth disease and related diseases. Muscular Dystrophy Association. https://www.mda.org/disease/charcot-marie-tooth. Accessed Dec. 31, 2020. Neurotoxic medications. Charcot-Marie-Tooth Association. https://www.cmtausa.org/living-with-cmt/managing-cmt/medications/. Accessed Dec. 31, 2020. Simon RP, et al. Sensory disorders. In: Clinical Neurology. 10th ed. McGraw-Hill; 2018. https://accessmedicine.mhmedical.com. Accessed Dec. 31, 2020. Kang PB. Charcot-Marie-Tooth disease: Management and prognosis. https://www.uptodate.com/contents/search. Accessed Dec. 31, 2020. Rossor AM, et al. Are we prepared for clinical trials in Charcot-Marie-Tooth disease? Brain Research. 2020; doi:10.1016/j.brainres.2019.146625. 2019.146625 2019.146625 Pareyson D, et al. New developments in Charcot-Marie-Tooth neuropathy and related diseases. Current Opinion in Neurology. 2017; doi:10.1097/WCO. 0000000000000474. Important foot care for people with CMT. Charcot-Marie-Tooth Association. https://www.cmtausa.org/living-with-cmt/managing-cmt/important-foot-care-for-people-with-cmt/. Accessed Dec. 31, 2020. Pedicure pointers. American Podiatric Medical Association. https://www.apma.org/Patients/HealthyFeetTips.cfm?ItemNumber=9859. Accessed Dec. 31, 2020. Related Associated Procedures Electromyography (EMG) Gene therapy Genetic testing Knee braces for osteoarthritis Show more associated procedures Products & Services Book: Mayo Clinic Family Health Book, 5th Edition Newsletter: Mayo Clinic Health Letter — Digital Edition Show more products and services from Mayo Clinic Related Associated Procedures Electromyography (EMG) Gene therapy Genetic testing Knee braces for osteoarthritis Show more associated procedures Associated Procedures Electromyography (EMG) Gene therapy Genetic testing Knee braces for osteoarthritis Show more associated procedures Products & Services Book: Mayo Clinic Family Health Book, 5th Edition Newsletter: Mayo Clinic Health Letter — Digital Edition Show more products and services from Mayo Clinic Products & Services Book: Mayo Clinic Family Health Book, 5th Edition Newsletter: Mayo Clinic Health Letter — Digital Edition Show more products and services from Mayo Clinic Charcot-Marie-Tooth diseaseSymptoms & causesDiagnosis & treatmentDoctors & departments Charcot-Marie-Tooth disease Symptoms & causesDiagnosis & treatmentDoctors & departments

charcot-marie-tooth-disease

Parkinson's disease signs and symptoms can be different for everyone. Early signs may be mild and go unnoticed. Symptoms often begin on one side of the body and usually remain worse on that side, even after symptoms begin to affect the limbs on both sides. Parkinson's signs and symptoms may include: Tremor. A tremor, or rhythmic shaking, usually begins in a limb, often your hand or fingers. You may rub your thumb and forefinger back and forth. This is known as a pill-rolling tremor. Your hand may tremble when it's at rest. The shaking may decrease when you are performing tasks. Slowed movement (bradykinesia). Over time, Parkinson's disease may slow your movement, making simple tasks difficult and time-consuming. Your steps may become shorter when you walk. It may be difficult to get out of a chair. You may drag or shuffle your feet as you try to walk. Rigid muscles. Muscle stiffness may occur in any part of your body. The stiff muscles can be painful and limit your range of motion. Impaired posture and balance. Your posture may become stooped. Or you may fall or have balance problems as a result of Parkinson's disease. Loss of automatic movements. You may have a decreased ability to perform unconscious movements, including blinking, smiling or swinging your arms when you walk. Speech changes. You may speak softly, quickly, slur or hesitate before talking. Your speech may be more of a monotone rather than have the usual speech patterns. Writing changes. It may become hard to write, and your writing may appear small.

parkinsons-disease

Vaginitis signs and symptoms can include: Change in color, odor or amount of discharge from your vagina Vaginal itching or irritation Pain during sex Painful urination Light vaginal bleeding or spotting If you have vaginal discharge, the characteristics of the discharge might indicate the type of vaginitis you have. Examples include: Bacterial vaginosis. You might develop a grayish-white, foul-smelling discharge. The odor, often described as a fishy odor, might be more obvious after sex. Yeast infection. The main symptom is itching, but you might have a thick white discharge that resembles cottage cheese. Trichomoniasis. An infection called trichomoniasis (trik-o-moe-NIE-uh-sis) can cause a greenish-yellow, sometimes frothy discharge.

vaginitis

The most common signs and symptoms of juvenile idiopathic arthritis are: Pain. While your child might not complain of joint pain, you may notice that he or she limps — especially first thing in the morning or after a nap. Swelling. Joint swelling is common but is often first noticed in larger joints such as the knee. Stiffness. You might notice that your child appears clumsier than usual, particularly in the morning or after naps. Fever, swollen lymph nodes and rash. In some cases, high fever, swollen lymph nodes or a rash on the trunk may occur — which is usually worse in the evenings. Juvenile idiopathic arthritis can affect one joint or many. There are several different subtypes of juvenile idiopathic arthritis, but the main ones are systemic, oligoarticular and polyarticular. Which type your child has depends on symptoms, the number of joints affected, and if a fever and rashes are prominent features. Like other forms of arthritis, juvenile idiopathic arthritis is characterized by times when symptoms flare up and times when symptoms may be minimal.

juvenile-idiopathic-arthritis

A hamstring injury typically causes a sudden, sharp pain in the back of the thigh. There might also be a "popping" or tearing sensation. Swelling and tenderness usually develop within a few hours. There might be bruising or a change in skin color along the back of the leg. Some people have muscle weakness or are not able to put weight on the injured leg.

hamstring-injury

Most people with trichomoniasis have no signs or symptoms. However, symptoms may develop over time. When signs and symptoms develop, they are different for men and women. In women, trichomoniasis signs and symptoms include: A large amount of a thin, often foul-smelling discharge from the vagina — which might be clear, white, gray, yellow or green Genital redness, burning and itching Pain with urination or sex Discomfort over the lower stomach area In men, trichomoniasis rarely causes symptoms. When men do have signs and symptoms, however, they might include: Itching or irritation inside the penis Burning with urination or after ejaculation Discharge from the penis

trichomoniasis

Many people with polycythemia vera don't have noticeable signs or symptoms. Some people might develop vague symptoms such as headache, dizziness, fatigue and blurred vision. More-specific symptoms of polycythemia vera include: Itchiness, especially after a warm bath or shower Numbness, tingling, burning, or weakness in your hands, feet, arms or legs A feeling of fullness soon after eating and bloating or pain in your left upper abdomen due to an enlarged spleen Unusual bleeding, such as a nosebleed or bleeding gums Painful swelling of one joint, often the big toe Shortness of breath and difficulty breathing when lying down

polycythemia-vera

Most kids are fully toilet trained by age 5, but there's really no target date for developing complete bladder control. Between the ages of 5 and 7, bed-wetting remains a problem for some children. After 7 years of age, a small number of children still wet the bed.

bed-wetting

Your limbs have specific areas of muscle (compartments). Your lower leg, for example, has four compartments. Chronic exertional compartment syndrome often occurs in the same compartment of an affected limb on both sides of the body, usually the lower leg. Signs and symptoms can include: Aching, burning or cramping pain in a compartment of the affected limb Tightness in the affected limb Numbness or tingling in the affected limb Weakness of the affected limb Foot drop, in severe cases, if legs are affected Occasionally, swelling or bulging as a result of a muscle hernia Pain caused by chronic exertional compartment syndrome typically follows this pattern: Begins consistently after a certain time, distance or intensity of exertion after you start exercising the affected limb Progressively worsens as you exercise Becomes less intense or stops completely within 15 minutes of stopping the activity Over time, recovery time after exercise may increase Taking a complete break from exercise or performing only low-impact activity might relieve your symptoms, but relief is usually only temporary. Once you take up running again, for instance, those familiar symptoms usually come back.

chronic-exertional-compartment-syndrome

Hepatitis A symptoms typically appear a few weeks after you've had the virus. But not everyone with hepatitis A develops symptoms. If you do, symptoms can include: Unusual tiredness and weakness Sudden nausea and vomiting and diarrhea Abdominal pain or discomfort, especially on the upper right side beneath your lower ribs, which is over your liver Clay- or gray-colored stool Loss of appetite Low-grade fever Dark urine Joint pain Yellowing of the skin and the whites of your eyes (jaundice) Intense itching These symptoms may be relatively mild and go away in a few weeks. Sometimes, however, hepatitis A results in a severe illness that lasts several months.

hepatitis-a

Seborrheic dermatitis signs and symptoms may include: Flaking skin (dandruff) on your scalp, hair, eyebrows, beard or mustache Patches of greasy skin covered with flaky white or yellow scales or crust on the scalp, face, sides of the nose, eyebrows, ears, eyelids, chest, armpits, groin area or under the breasts Rash that may look darker or lighter in people with brown or Black skin and redder in those with white skin Ring-shaped (annular) rash, for a type called petaloid seborrheic dermatitis Itchiness (pruritus) The signs and symptoms of seborrheic dermatitis tend to flare with stress, fatigue or a change of season.

seborrheic-dermatitis

Burning stomach pain Feeling of fullness, bloating or belching Intolerance to fatty foods Heartburn Nausea The most common peptic ulcer symptom is burning stomach pain. Stomach acid makes the pain worse, as does having an empty stomach. The pain can often be relieved by eating certain foods that buffer stomach acid or by taking an acid-reducing medication, but then it may come back. The pain may be worse between meals and at night. Many people with peptic ulcers don't even have symptoms. Less often, ulcers may cause severe signs or symptoms such as: Vomiting or vomiting blood — which may appear red or black Dark blood in stools, or stools that are black or tarry Trouble breathing Feeling faint Nausea or vomiting Unexplained weight loss Appetite changes

peptic-ulcer

Pancreatic neuroendocrine tumors sometimes don't cause symptoms. When they do, signs and symptoms can include: Stomach ulcers Heartburn Diabetes Weakness Fatigue Muscle cramps Indigestion Diarrhea Weight loss Skin rash Constipation Pain in your abdomen or back Yellowing of your skin or eyes Low blood sugar Causes It's not clear what causes most pancreatic neuroendocrine tumors. Pancreatic neuroendocrine tumors occur when hormone-producing cells in the pancreas (islet cells) develop changes (mutations) in their DNA — the material that provides instructions for every chemical process in your body. DNA mutations cause changes in these instructions. One result is that cells may begin to grow out of control and eventually form a tumor — a mass of cancerous cells. Sometimes the cancer cells break away and spread to other organs, such as the liver. Some inherited syndromes increase the risk of this type of cancer, including: Multiple endocrine neoplasia, type 1 (MEN 1) syndrome Von Hippel-Lindau disease Von Recklinghausen's disease (neurofibromatosis 1) Tuberous sclerosis Risk factors Factors that are associated with an increased risk of pancreatic neuroendocrine tumors include: Being male. Men are much more likely than women to develop these tumors. A family history of pancreatic neuroendocrine tumors. If a family member was diagnosed with pancreatic neuroendocrine tumor, your risk is increased. You may have multiple endocrine neoplasia, type 1 (MEN 1) syndrome, which increases the risk of this type of tumor. By Mayo Clinic Staff By Mayo Clinic Staff Pancreatic neuroendocrine tumors care at Mayo Clinic

pancreatic-neuroendocrine-tumors

Leukoplakia usually occurs on your gums, the insides of your cheeks, the bottom of your mouth — beneath the tongue — and, sometimes, your tongue. It isn't usually painful and may go unnoticed for a while. Leukoplakia may appear: White or grayish in patches that can't be wiped away Irregular or flat-textured Thickened or hardened in areas Along with raised, red lesions (speckled leukoplakia or erythroplakia), which are more likely to show precancerous changes Hairy leukoplakia Hairy leukoplakia causes fuzzy, white patches that resemble folds or ridges, usually on the sides of your tongue. It's often mistaken for oral thrush, an infection marked by creamy white patches that can be wiped away, which is also common in people with a weakened immune system. When to see a doctor Even though leukoplakia doesn't usually cause discomfort, sometimes it can indicate a more serious condition. See your dentist or primary care professional if you have any of the following: White plaques or sores in your mouth that don't heal on their own within two weeks Lumps or white, red or dark patches in your mouth Persistent changes in the tissues of your mouth Ear pain when swallowing Progressive reduction in the ability to open your jaw

leukoplakia

Pemphigus causes blisters on your skin and mucous membranes. The blisters rupture easily, leaving open sores, which may ooze and become infected. The signs and symptoms of two common types of pemphigus are as follows: Pemphigus vulgaris. This type usually begins with blisters in your mouth and then on your skin or genital mucous membranes. The blisters typically are painful but don't itch. Blisters in your mouth or throat may make it hard to swallow and eat. Pemphigus foliaceus. This type causes blisters on the chest, back and shoulders. The blisters tend to be more itchy than painful. Pemphigus foliaceus doesn't cause mouth blisters. Pemphigus is distinct from bullous pemphigoid, which is a blistering skin condition that affects older adults and may cause death.

pemphigus

Signs and symptoms of acoustic neuroma are often easy to miss and may take many years to develop. They usually happen because of the tumor's effects on the hearing and balance nerves. Pressure from the tumor on nearby nerves controlling facial muscles and sensation (facial and trigeminal nerves), nearby blood vessels, or brain structures may also cause problems. As the tumor grows, it may cause more noticeable or severe signs and symptoms. Common signs and symptoms of acoustic neuroma include: Hearing loss, usually gradually worsening over months to years — although in rare cases sudden — and occurring on only one side or more severe on one side Ringing (tinnitus) in the affected ear Unsteadiness or loss of balance Dizziness (vertigo) Facial numbness and weakness or loss of muscle movement In rare cases, an acoustic neuroma may grow large enough to compress the brainstem and become life-threatening. When to see your doctor See your doctor if you notice hearing loss in one ear, ringing in your ear or trouble with your balance. Early diagnosis of an acoustic neuroma may help keep the tumor from growing large enough to cause serious consequences, such as total hearing loss.

acoustic-neuroma

The primary symptom of microcephaly is having a head size that is much smaller than that of other children of the same age and sex. Head size is a measure of the distance around the top of the child's head (circumference). Using standardized growth charts, health care providers compare the measurement with other children's measurements in percentiles. Some children just have small heads, with a measurement that falls below an established value for children of the same age and sex. In children with microcephaly, head size measures much smaller than average for the child's age and sex. A child with more-severe microcephaly may also have a sloping forehead.

microcephaly

Shoulder dislocation Open pop-up dialog box Close Shoulder dislocation Shoulder dislocation The shoulder joint is the most frequently dislocated joint of the body. Because it moves in several directions, your shoulder can dislocate forward, backward or downward. The most common variety is a forward (anterior) dislocation. Shoulder dislocation Open pop-up dialog box Shoulder dislocation Open pop-up dialog box Open pop-up dialog box Close Shoulder dislocation Shoulder dislocation The shoulder joint is the most frequently dislocated joint of the body. Because it moves in several directions, your shoulder can dislocate forward, backward or downward. The most common variety is a forward (anterior) dislocation. Close Shoulder dislocation Shoulder dislocation The shoulder joint is the most frequently dislocated joint of the body. Because it moves in several directions, your shoulder can dislocate forward, backward or downward. The most common variety is a forward (anterior) dislocation. Close Shoulder dislocation Shoulder dislocation The shoulder joint is the most frequently dislocated joint of the body. Because it moves in several directions, your shoulder can dislocate forward, backward or downward. The most common variety is a forward (anterior) dislocation. Close Close Close Shoulder dislocation Shoulder dislocation The shoulder joint is the most frequently dislocated joint of the body. Because it moves in several directions, your shoulder can dislocate forward, backward or downward. The most common variety is a forward (anterior) dislocation. Shoulder dislocation The shoulder joint is the most frequently dislocated joint of the body. Because it moves in several directions, your shoulder can dislocate forward, backward or downward. The most common variety is a forward (anterior) dislocation. The shoulder joint is the most frequently dislocated joint of the body. Because it moves in several directions, your shoulder can dislocate forward, backward or downward. The most common variety is a forward (anterior) dislocation. Dislocated shoulder symptoms can include: A visibly deformed or out-of-place shoulder Swelling or bruising Intense pain Inability to move the joint Shoulder dislocation can also cause numbness, weakness or tingling near the injury, such as in the neck or down the arm. The muscles in the shoulder might spasm, which can increase the pain.

dislocated-shoulder

Most of the time, gestational diabetes doesn't cause noticeable signs or symptoms. Increased thirst and more-frequent urination are possible symptoms.

gestational-diabetes