family_id
int64 1
1.1k
| family_type
stringclasses 9
values | family_name
stringclasses 590
values | target_id
int64 1
3.29k
| target_name
stringlengths 3
122
| ligand_id
int64 1
13.4k
| ligand_name
stringlengths 2
141
| ligand_type
stringclasses 6
values | interaction_id
int64 1
90.9k
| interaction_type
stringclasses 11
values | interaction_action
stringclasses 25
values | ligand_approved
bool 2
classes | ligand_approval_source
stringclasses 440
values | ligand_pubchem_sid
float64 53.8M
491M
⌀ | interaction_primary_target
bool 2
classes | interaction_affinity_median
float64 0.3
13
⌀ | interaction_affinity_units
stringclasses 7
values | reference_id
float64 21
47.8k
⌀ | reference_type
stringclasses 4
values | reference_title
stringclasses 714
values | reference_article_title
stringlengths 0
409
⌀ | reference_pubmed_id
float64 156k
38.9M
⌀ | reference_doi
stringclasses 154
values | reference_pmc_id
stringlengths 7
11
⌀ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
84 | nhr | 1A. Thyroid hormone receptors | 589 | Thyroid hormone receptor-β | 12,768 | VK2809 | Synthetic organic | 89,885 | Agonist | Agonist | false | 483,123,316 | false | 8.53 | pKi | 45,720 | Journal | J Med Chem | Synthesis and biological evaluation of a series of liver-selective phosphonic acid thyroid hormone receptor agonists and their prodrugs. | 18,975,928 | null |
||
84 | nhr | 1A. Thyroid hormone receptors | 589 | Thyroid hormone receptor-β | 2,635 | T<sub>4</sub> | Metabolite | 6,268 | Agonist | Agonist | true | FDA (2000) | 135,651,574 | true | 8.52 | pIC50 | 10,040 | Journal | Mol Endocrinol | Binding of 3,5,3'-triiodothyronine (T3) and its analogs to the in vitro translational products of c-erbA protooncogenes: differences in the affinity of the alpha- and beta-forms for the acetic acid analog and failure of the human testis and kidney alpha-2 products to bind T3. | 2,158,622 | null | null |
84 | nhr | 1A. Thyroid hormone receptors | 589 | Thyroid hormone receptor-β | 2,634 | triiodothyronine | Metabolite | 6,269 | Agonist | Agonist | true | FDA (1956) | 135,651,573 | true | 10.1 | pKd | 10,041 | Journal | J Med Chem | Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. | 12,109,914 | null | null |
84 | nhr | 1A. Thyroid hormone receptors | 589 | Thyroid hormone receptor-β | 2,637 | tiratricol | Metabolite | 6,265 | Agonist | Agonist | false | 135,651,405 | null | 10.7 | pKd | 10,040 | Journal | Mol Endocrinol | Binding of 3,5,3'-triiodothyronine (T3) and its analogs to the in vitro translational products of c-erbA protooncogenes: differences in the affinity of the alpha- and beta-forms for the acetic acid analog and failure of the human testis and kidney alpha-2 products to bind T3. | 2,158,622 | null | null |
|
84 | nhr | 1A. Thyroid hormone receptors | 589 | Thyroid hormone receptor-β | 2,639 | sobetirome | Synthetic organic | 6,266 | Agonist | Agonist | false | 135,650,297 | null | 10.17 | pKd | 14,197 | Journal | Chem Biol | A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor. | 9,653,548 | null | null |
|
84 | nhr | 1A. Thyroid hormone receptors | 589 | Thyroid hormone receptor-β | 2,639 | sobetirome | Synthetic organic | 6,266 | Agonist | Agonist | false | 135,650,297 | null | 10.17 | pKd | 5,272 | Journal | Proc Natl Acad Sci USA | Opiate-dependent modulation of adenylate cyclase. | 269,396 | null | PMC431562 |
|
84 | nhr | 1A. Thyroid hormone receptors | 589 | Thyroid hormone receptor-β | 2,636 | rT<sub>3</sub> | Synthetic organic | 6,270 | Agonist | Agonist | false | 135,650,897 | null | 7.34 | pKd | 10,040 | Journal | Mol Endocrinol | Binding of 3,5,3'-triiodothyronine (T3) and its analogs to the in vitro translational products of c-erbA protooncogenes: differences in the affinity of the alpha- and beta-forms for the acetic acid analog and failure of the human testis and kidney alpha-2 products to bind T3. | 2,158,622 | null | null |
|
84 | nhr | 1A. Thyroid hormone receptors | 589 | Thyroid hormone receptor-β | 12,026 | resmetirom | Synthetic organic | 88,708 | Agonist | Agonist | true | FDA (2024) | 464,244,167 | false | 6.68 | pEC50 | 43,758 | Journal | J Med Chem | Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β agonist in clinical trials for the treatment of dyslipidemia. | 24,712,661 | null |
|
84 | nhr | 1A. Thyroid hormone receptors | 589 | Thyroid hormone receptor-β | 2,633 | NH-3 | Synthetic organic | 6,264 | Antagonist | Antagonist | false | 135,650,713 | null | 7.03 | pKd | 10,041 | Journal | J Med Chem | Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. | 12,109,914 | null | null |
|
84 | nhr | 1A. Thyroid hormone receptors | 589 | Thyroid hormone receptor-β | 2,638 | KB-141 | Synthetic organic | 6,267 | Agonist | Agonist | false | 135,650,452 | null | 8.96 | pIC50 | 10,043 | Journal | Proc Natl Acad Sci USA | Selective thyroid hormone receptor-beta activation: a strategy for reduction of weight, cholesterol, and lipoprotein (a) with reduced cardiovascular liability. | 12,888,625 | null | PMC187768 |
|
84 | nhr | 1A. Thyroid hormone receptors | 589 | Thyroid hormone receptor-β | 6,951 | dextrothyroxine | Synthetic organic | 79,002 | Agonist | Agonist | true | FDA (1967) | 178,103,533 | true | null | - | 23,507 | Journal | J Clin Endocrinol Metab | Effects of dextrothyroxine on the pituitary-thyroid axis in hypercholesterolemic children and goitrous adults. | 6,777,394 | null | null |
84 | nhr | 1A. Thyroid hormone receptors | 589 | Thyroid hormone receptor-β | 12,028 | compound 16g [PMID: 35507418] | Synthetic organic | 88,709 | Agonist | Agonist | false | 464,244,169 | false | 7.68 | pEC50 | 43,759 | Journal | J Med Chem | Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor β Agonist. | 35,507,418 | null |
||
84 | nhr | 1A. Thyroid hormone receptors | 588 | Thyroid hormone receptor-α | 12,768 | VK2809 | Synthetic organic | 89,886 | Agonist | Agonist | false | 483,123,316 | false | 7.45 | pKi | 45,720 | Journal | J Med Chem | Synthesis and biological evaluation of a series of liver-selective phosphonic acid thyroid hormone receptor agonists and their prodrugs. | 18,975,928 | null |
||
84 | nhr | 1A. Thyroid hormone receptors | 588 | Thyroid hormone receptor-α | 2,635 | T<sub>4</sub> | Metabolite | 6,259 | Agonist | Agonist | true | FDA (2000) | 135,651,574 | true | null | pIC50 | 10,040 | Journal | Mol Endocrinol | Binding of 3,5,3'-triiodothyronine (T3) and its analogs to the in vitro translational products of c-erbA protooncogenes: differences in the affinity of the alpha- and beta-forms for the acetic acid analog and failure of the human testis and kidney alpha-2 products to bind T3. | 2,158,622 | null | null |
84 | nhr | 1A. Thyroid hormone receptors | 588 | Thyroid hormone receptor-α | 2,637 | tiratricol | Metabolite | 6,261 | Agonist | Agonist | false | 135,651,405 | null | null | pIC50 | 10,040 | Journal | Mol Endocrinol | Binding of 3,5,3'-triiodothyronine (T3) and its analogs to the in vitro translational products of c-erbA protooncogenes: differences in the affinity of the alpha- and beta-forms for the acetic acid analog and failure of the human testis and kidney alpha-2 products to bind T3. | 2,158,622 | null | null |
|
84 | nhr | 1A. Thyroid hormone receptors | 588 | Thyroid hormone receptor-α | 2,634 | triiodothyronine | Metabolite | 6,258 | Agonist | Agonist | true | FDA (1956) | 135,651,573 | true | 10 | pKd | 10,041 | Journal | J Med Chem | Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. | 12,109,914 | null | null |
85 | nhr | 1B. Retinoic acid receptors | 592 | Retinoic acid receptor-γ | 2,653 | BMS270394 | Synthetic organic | 6,292 | Agonist | Agonist | false | 135,650,002 | null | 6.3 | pIC50 | 10,110 | Journal | J Mol Biol | Structural basis for isotype selectivity of the human retinoic acid nuclear receptor. | 10,964,567 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 592 | Retinoic acid receptor-γ | 2,653 | BMS270394 | Synthetic organic | 6,292 | Agonist | Agonist | false | 135,650,002 | null | 6.3 | pIC50 | 10,188 | Journal | Proc Natl Acad Sci USA | Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARgamma. | 10,841,540 | null | PMC18601 |
|
85 | nhr | 1B. Retinoic acid receptors | 592 | Retinoic acid receptor-γ | 2,645 | alitretinoin | Metabolite | 6,289 | Agonist | Agonist | true | FDA (1999), EMA (2000) | 135,651,418 | true | 9 | pKd | 10,129 | Journal | Mol Cell Biol | Activation of retinoid X receptors induces apoptosis in HL-60 cell lines. | 7,791,761 | null | PMC230591 |
85 | nhr | 1B. Retinoic acid receptors | 592 | Retinoic acid receptor-γ | 2,645 | alitretinoin | Metabolite | 6,289 | Agonist | Agonist | true | FDA (1999), EMA (2000) | 135,651,418 | true | 9 | pKd | 10,110 | Journal | J Mol Biol | Structural basis for isotype selectivity of the human retinoic acid nuclear receptor. | 10,964,567 | null | null |
85 | nhr | 1B. Retinoic acid receptors | 592 | Retinoic acid receptor-γ | 3,431 | AHPN | Synthetic organic | 7,549 | Agonist | Agonist | false | 178,100,433 | null | 7.11 | pKi | 23,117 | Journal | J Med Chem | Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes. | 8,544,175 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 592 | Retinoic acid receptor-γ | 2,640 | AGN193109 | Synthetic organic | 6,293 | Antagonist | Antagonist | false | 135,649,903 | null | 8.5 | pIC50 | 10,112 | Journal | J Biol Chem | Recruitment of nuclear receptor corepressor and coactivator to the retinoic acid receptor by retinoid ligands. Influence of DNA-heterodimer interactions. | 10,777,502 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 592 | Retinoic acid receptor-γ | 2,640 | AGN193109 | Synthetic organic | 6,293 | Antagonist | Antagonist | false | 135,649,903 | null | 8.5 | pIC50 | 10,111 | Journal | J Biol Chem | Identification and functional separation of retinoic acid receptor neutral antagonists and inverse agonists. | 8,798,442 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 592 | Retinoic acid receptor-γ | 2,640 | AGN193109 | Synthetic organic | 6,293 | Antagonist | Antagonist | false | 135,649,903 | null | 8.5 | pIC50 | 10,144 | Journal | Curr Pharm Des | Therapeutic applications for ligands of retinoid receptors. | 10,637,371 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 592 | Retinoic acid receptor-γ | 5,429 | adapalene | Synthetic organic | 79,542 | Agonist | Agonist | true | FDA (1996) | 178,102,082 | true | 6.89 | pKi | 23,117 | Journal | J Med Chem | Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes. | 8,544,175 | null | null |
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 2,646 | TTNPB | Synthetic organic | 6,285 | Agonist | Agonist | false | 135,651,285 | null | 8 | pIC50 | 10,129 | Journal | Mol Cell Biol | Activation of retinoid X receptors induces apoptosis in HL-60 cell lines. | 7,791,761 | null | PMC230591 |
|
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 2,646 | TTNPB | Synthetic organic | 6,285 | Agonist | Agonist | false | 135,651,285 | null | 8 | pIC50 | 10,109 | Journal | Mol Cell Biol | Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping. | 8,264,595 | null | PMC358378 |
|
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 2,646 | TTNPB | Synthetic organic | 6,285 | Agonist | Agonist | false | 135,651,285 | null | 8 | pIC50 | 10,110 | Journal | J Mol Biol | Structural basis for isotype selectivity of the human retinoic acid nuclear receptor. | 10,964,567 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 2,646 | TTNPB | Synthetic organic | 6,285 | Agonist | Agonist | false | 135,651,285 | null | 8 | pIC50 | 10,144 | Journal | Curr Pharm Des | Therapeutic applications for ligands of retinoid receptors. | 10,637,371 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 9,962 | trifarotene | Synthetic organic | 85,232 | Agonist | Agonist | true | FDA (2019) | 374,883,849 | false | 6.9 | pEC50 | 35,100 | Journal | Bioorg Med Chem Lett | Structure-based design of Trifarotene (CD5789), a potent and selective RARγ agonist for the treatment of acne. | 29,706,423 | null |
|
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 2,644 | tretinoin | Metabolite | 6,287 | Agonist | Agonist | true | FDA (1995) | 135,651,435 | true | 9.4 | pKi | 10,144 | Journal | Curr Pharm Des | Therapeutic applications for ligands of retinoid receptors. | 10,637,371 | null | null |
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 2,644 | tretinoin | Metabolite | 6,287 | Agonist | Agonist | true | FDA (1995) | 135,651,435 | true | 9.4 | pKi | 10,109 | Journal | Mol Cell Biol | Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping. | 8,264,595 | null | PMC358378 |
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 2,644 | tretinoin | Metabolite | 6,287 | Agonist | Agonist | true | FDA (1995) | 135,651,435 | true | 9.4 | pKi | 10,129 | Journal | Mol Cell Biol | Activation of retinoid X receptors induces apoptosis in HL-60 cell lines. | 7,791,761 | null | PMC230591 |
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 2,644 | tretinoin | Metabolite | 6,287 | Agonist | Agonist | true | FDA (1995) | 135,651,435 | true | 9.4 | pKi | 10,110 | Journal | J Mol Biol | Structural basis for isotype selectivity of the human retinoic acid nuclear receptor. | 10,964,567 | null | null |
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 2,644 | tretinoin | Metabolite | 79,006 | Agonist | Agonist | true | FDA (1995) | 135,651,435 | true | 7.92 | pEC50 | 23,508 | Journal | Bioorg Med Chem Lett | Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives. | 19,058,965 | null | null |
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 6,952 | tazarotene | Synthetic organic | 79,005 | Agonist | Agonist | true | FDA (1997) | 178,103,534 | true | 9.1 | pEC50 | 23,508 | Journal | Bioorg Med Chem Lett | Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives. | 19,058,965 | null | null |
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 2,648 | tamibarotene | Synthetic organic | 83,088 | Agonist | Agonist | true | 135,649,930 | false | 6.63 | pEC50 | 30,137 | Journal | J Med Chem | Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives. | 20,925,433 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 5,383 | [<sup>3</sup>H]9-cis-retinoic acid | Synthetic organic | 80,599 | Agonist | Full agonist | false | 178,102,041 | false | 9.4 | pKd | 10,085 | Journal | Proc Natl Acad Sci USA | Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. | 8,380,496 | null | PMC45593 |
|
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 2,647 | Ro 40-6055 | Synthetic organic | 83,083 | Agonist | Agonist | false | 135,650,917 | false | 8.07 | pEC50 | 23,508 | Journal | Bioorg Med Chem Lett | Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives. | 19,058,965 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 12,792 | KCL-286 | Synthetic organic | 89,906 | Agonist | Agonist | false | 483,123,340 | false | 8.72 | pEC50 | 45,772 | Journal | Bioorg Med Chem Lett | Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury. | 30,792,038 | null |
||
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 2,652 | CD666 | Synthetic organic | 6,296 | Agonist | Agonist | false | 53,801,005 | null | 5.64 | pKd | 10,177 | Journal | Biochem Biophys Res Commun | Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma. | 1,323,296 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 2,651 | BMS641 | Synthetic organic | 6,284 | Agonist | Agonist | false | 135,650,005 | null | 8.6 | pIC50 | 10,157 | Journal | EMBO Rep | Rational design of RAR-selective ligands revealed by RARbeta crystal stucture. | 15,319,780 | null | PMC1299136 |
|
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 2,641 | BMS493 | Synthetic organic | 6,283 | Antagonist | Inverse agonist | false | 135,650,003 | null | 8.54 | pIC50 | 10,105 | Journal | Nature | Co-regulator recruitment and the mechanism of retinoic acid receptor synergy. | 11,805,839 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 2,645 | alitretinoin | Metabolite | 6,286 | Agonist | Agonist | true | FDA (1999), EMA (2000) | 135,651,418 | true | 9.7 | pKi | 10,110 | Journal | J Mol Biol | Structural basis for isotype selectivity of the human retinoic acid nuclear receptor. | 10,964,567 | null | null |
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 2,645 | alitretinoin | Metabolite | 6,286 | Agonist | Agonist | true | FDA (1999), EMA (2000) | 135,651,418 | true | 9.7 | pKi | 10,129 | Journal | Mol Cell Biol | Activation of retinoid X receptors induces apoptosis in HL-60 cell lines. | 7,791,761 | null | PMC230591 |
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 2,640 | AGN193109 | Synthetic organic | 6,282 | Antagonist | Inverse agonist | false | 135,649,903 | null | 8.7 | pIC50 | 10,112 | Journal | J Biol Chem | Recruitment of nuclear receptor corepressor and coactivator to the retinoic acid receptor by retinoid ligands. Influence of DNA-heterodimer interactions. | 10,777,502 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 2,640 | AGN193109 | Synthetic organic | 6,282 | Antagonist | Inverse agonist | false | 135,649,903 | null | 8.7 | pIC50 | 10,111 | Journal | J Biol Chem | Identification and functional separation of retinoic acid receptor neutral antagonists and inverse agonists. | 8,798,442 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 2,640 | AGN193109 | Synthetic organic | 6,282 | Antagonist | Inverse agonist | false | 135,649,903 | null | 8.7 | pIC50 | 10,144 | Journal | Curr Pharm Des | Therapeutic applications for ligands of retinoid receptors. | 10,637,371 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 5,429 | adapalene | Synthetic organic | 79,541 | Agonist | Agonist | true | FDA (1996) | 178,102,082 | true | 7.47 | pKi | 23,117 | Journal | J Med Chem | Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes. | 8,544,175 | null | null |
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 4,055 | AC55649 | Synthetic organic | 9,448 | Agonist | Full agonist | false | 178,100,879 | false | null | pEC50 | 30,135 | Journal | J Med Chem | Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor beta ligands. | 19,239,230 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 4,055 | AC55649 | Synthetic organic | 9,448 | Agonist | Full agonist | false | 178,100,879 | false | null | pEC50 | 15,351 | Journal | J Med Chem | Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist. | 16,302,793 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 591 | Retinoic acid receptor-β | 4,054 | AC261066 | Synthetic organic | 9,447 | Agonist | Full agonist | false | 178,100,878 | null | null | pEC50 | 15,351 | Journal | J Med Chem | Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist. | 16,302,793 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,646 | TTNPB | Synthetic organic | 6,279 | Agonist | Agonist | false | 135,651,285 | null | 7.44 | pIC50 | 10,110 | Journal | J Mol Biol | Structural basis for isotype selectivity of the human retinoic acid nuclear receptor. | 10,964,567 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,646 | TTNPB | Synthetic organic | 6,279 | Agonist | Agonist | false | 135,651,285 | null | 7.44 | pIC50 | 10,109 | Journal | Mol Cell Biol | Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping. | 8,264,595 | null | PMC358378 |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,646 | TTNPB | Synthetic organic | 6,279 | Agonist | Agonist | false | 135,651,285 | null | 7.44 | pIC50 | 10,129 | Journal | Mol Cell Biol | Activation of retinoid X receptors induces apoptosis in HL-60 cell lines. | 7,791,761 | null | PMC230591 |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,646 | TTNPB | Synthetic organic | 6,279 | Agonist | Agonist | false | 135,651,285 | null | 7.44 | pIC50 | 10,144 | Journal | Curr Pharm Des | Therapeutic applications for ligands of retinoid receptors. | 10,637,371 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 9,962 | trifarotene | Synthetic organic | 85,231 | Agonist | Agonist | true | FDA (2019) | 374,883,849 | false | 6.3 | pEC50 | 35,100 | Journal | Bioorg Med Chem Lett | Structure-based design of Trifarotene (CD5789), a potent and selective RARγ agonist for the treatment of acne. | 29,706,423 | null |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,644 | tretinoin | Metabolite | 6,281 | Agonist | Agonist | true | FDA (1995) | 135,651,435 | true | 9.4 | pKd | 10,109 | Journal | Mol Cell Biol | Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping. | 8,264,595 | null | PMC358378 |
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,644 | tretinoin | Metabolite | 6,281 | Agonist | Agonist | true | FDA (1995) | 135,651,435 | true | 9.4 | pKd | 10,129 | Journal | Mol Cell Biol | Activation of retinoid X receptors induces apoptosis in HL-60 cell lines. | 7,791,761 | null | PMC230591 |
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,644 | tretinoin | Metabolite | 6,281 | Agonist | Agonist | true | FDA (1995) | 135,651,435 | true | 9.4 | pKd | 10,085 | Journal | Proc Natl Acad Sci USA | Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. | 8,380,496 | null | PMC45593 |
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,644 | tretinoin | Metabolite | 6,281 | Agonist | Agonist | true | FDA (1995) | 135,651,435 | true | 9.4 | pKd | 10,144 | Journal | Curr Pharm Des | Therapeutic applications for ligands of retinoid receptors. | 10,637,371 | null | null |
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,644 | tretinoin | Metabolite | 79,003 | Agonist | Agonist | true | FDA (1995) | 135,651,435 | true | 7.77 | pEC50 | 23,508 | Journal | Bioorg Med Chem Lett | Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives. | 19,058,965 | null | null |
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,644 | tretinoin | Metabolite | 6,281 | Agonist | Agonist | true | FDA (1995) | 135,651,435 | true | 9.4 | pKd | 10,110 | Journal | J Mol Biol | Structural basis for isotype selectivity of the human retinoic acid nuclear receptor. | 10,964,567 | null | null |
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 6,952 | tazarotene | Synthetic organic | 79,004 | Agonist | Agonist | true | FDA (1997) | 178,103,534 | true | 7.2 | pEC50 | 23,508 | Journal | Bioorg Med Chem Lett | Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives. | 19,058,965 | null | null |
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,648 | tamibarotene | Synthetic organic | 6,277 | Agonist | Agonist | true | 135,649,930 | true | 6.9 | pIC50 | 10,108 | Journal | J Med Chem | Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity. | 3,184,125 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,648 | tamibarotene | Synthetic organic | 83,087 | Agonist | Agonist | true | 135,649,930 | true | 7.35 | pEC50 | 30,137 | Journal | J Med Chem | Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives. | 20,925,433 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,648 | tamibarotene | Synthetic organic | 6,277 | Agonist | Agonist | true | 135,649,930 | true | 6.9 | pIC50 | 10,129 | Journal | Mol Cell Biol | Activation of retinoid X receptors induces apoptosis in HL-60 cell lines. | 7,791,761 | null | PMC230591 |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,648 | tamibarotene | Synthetic organic | 6,277 | Agonist | Agonist | true | 135,649,930 | true | 6.9 | pIC50 | 10,144 | Journal | Curr Pharm Des | Therapeutic applications for ligands of retinoid receptors. | 10,637,371 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 5,383 | [<sup>3</sup>H]9-cis-retinoic acid | Synthetic organic | 80,598 | Agonist | Full agonist | false | 178,102,041 | false | 9.6 | pKd | 10,085 | Journal | Proc Natl Acad Sci USA | Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. | 8,380,496 | null | PMC45593 |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,642 | Ro 41-5253 | Synthetic organic | 6,274 | Antagonist | Antagonist | false | 135,650,918 | false | null | pIC50 | 10,109 | Journal | Mol Cell Biol | Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping. | 8,264,595 | null | PMC358378 |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,642 | Ro 41-5253 | Synthetic organic | 6,274 | Antagonist | Antagonist | false | 135,650,918 | false | null | pIC50 | 14,200 | Journal | Proc Natl Acad Sci USA | A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects. | 1,323,127 | null | PMC49659 |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,647 | Ro 40-6055 | Synthetic organic | 7,547 | Agonist | Agonist | false | 135,650,917 | false | null | pKd | 14,199 | Journal | Mol Pharmacol | Selective high affinity retinoic acid receptor alpha or beta-gamma ligands. | 1,656,191 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,647 | Ro 40-6055 | Synthetic organic | 83,084 | Agonist | Agonist | false | 135,650,917 | false | 9.52 | pEC50 | 23,508 | Journal | Bioorg Med Chem Lett | Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives. | 19,058,965 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,652 | CD666 | Synthetic organic | 6,297 | Agonist | Agonist | false | 53,801,005 | null | 5.65 | pKd | 10,177 | Journal | Biochem Biophys Res Commun | Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma. | 1,323,296 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,650 | BMS753 | Synthetic organic | 6,275 | Agonist | Agonist | false | 135,650,006 | null | 8.7 | pKi | 10,104 | Journal | Chem Biol | Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. | 10,421,757 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,643 | BMS614 | Synthetic organic | 6,273 | Antagonist | Antagonist | false | 135,650,004 | null | 8.7 | pIC50 | 10,089 | Journal | Mol Cell | Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains. | 10,882,070 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,643 | BMS614 | Synthetic organic | 6,273 | Antagonist | Antagonist | false | 135,650,004 | null | 8.7 | pIC50 | 10,105 | Journal | Nature | Co-regulator recruitment and the mechanism of retinoic acid receptor synergy. | 11,805,839 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,643 | BMS614 | Synthetic organic | 6,273 | Antagonist | Antagonist | false | 135,650,004 | null | 8.7 | pIC50 | 10,104 | Journal | Chem Biol | Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. | 10,421,757 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,641 | BMS493 | Synthetic organic | 6,272 | Antagonist | Inverse agonist | false | 135,650,003 | null | 8.4 | pIC50 | 10,105 | Journal | Nature | Co-regulator recruitment and the mechanism of retinoic acid receptor synergy. | 11,805,839 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 11,955 | BMS-189532 | Synthetic organic | 88,624 | Antagonist | Antagonist | false | 461,663,510 | false | 7.57 | pKd | 43,548 | Journal | J Med Chem | Identification of highly potent retinoic acid receptor alpha-selective antagonists. | 9,258,350 | null |
||
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,645 | alitretinoin | Metabolite | 6,280 | Agonist | Agonist | true | FDA (1999), EMA (2000) | 135,651,418 | true | 9.5 | pKd | 10,108 | Journal | J Med Chem | Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity. | 3,184,125 | null | null |
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,649 | AGN193836 | Synthetic organic | 6,276 | Agonist | Agonist | false | 135,649,904 | null | 8.4 | pKd | 10,087 | Journal | Bioorg Med Chem Lett | Synthesis and biological activity of retinoic acid receptor-alpha specific amides. | 12,372,520 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,645 | alitretinoin | Metabolite | 6,280 | Agonist | Agonist | true | FDA (1999), EMA (2000) | 135,651,418 | true | 9.5 | pKd | 10,129 | Journal | Mol Cell Biol | Activation of retinoid X receptors induces apoptosis in HL-60 cell lines. | 7,791,761 | null | PMC230591 |
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,640 | AGN193109 | Synthetic organic | 6,271 | Antagonist | Inverse agonist | false | 135,649,903 | null | 8.7 | pIC50 | 10,112 | Journal | J Biol Chem | Recruitment of nuclear receptor corepressor and coactivator to the retinoic acid receptor by retinoid ligands. Influence of DNA-heterodimer interactions. | 10,777,502 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,640 | AGN193109 | Synthetic organic | 6,271 | Antagonist | Inverse agonist | false | 135,649,903 | null | 8.7 | pIC50 | 10,111 | Journal | J Biol Chem | Identification and functional separation of retinoic acid receptor neutral antagonists and inverse agonists. | 8,798,442 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 2,640 | AGN193109 | Synthetic organic | 6,271 | Antagonist | Inverse agonist | false | 135,649,903 | null | 8.7 | pIC50 | 10,144 | Journal | Curr Pharm Des | Therapeutic applications for ligands of retinoid receptors. | 10,637,371 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 590 | Retinoic acid receptor-α | 5,429 | adapalene | Synthetic organic | 79,540 | Agonist | Agonist | true | FDA (1996) | 178,102,082 | false | 5.96 | pKi | 23,117 | Journal | J Med Chem | Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes. | 8,544,175 | null | null |
85 | nhr | 1B. Retinoic acid receptors | 592 | Retinoic acid receptor-γ | 2,646 | TTNPB | Synthetic organic | 6,290 | Agonist | Agonist | false | 135,651,285 | null | 7.82 | pIC50 | 10,109 | Journal | Mol Cell Biol | Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping. | 8,264,595 | null | PMC358378 |
|
85 | nhr | 1B. Retinoic acid receptors | 592 | Retinoic acid receptor-γ | 2,646 | TTNPB | Synthetic organic | 6,290 | Agonist | Agonist | false | 135,651,285 | null | 7.82 | pIC50 | 10,110 | Journal | J Mol Biol | Structural basis for isotype selectivity of the human retinoic acid nuclear receptor. | 10,964,567 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 592 | Retinoic acid receptor-γ | 9,962 | trifarotene | Synthetic organic | 85,230 | Agonist | Agonist | true | FDA (2019) | 374,883,849 | true | 8.11 | pEC50 | 35,100 | Journal | Bioorg Med Chem Lett | Structure-based design of Trifarotene (CD5789), a potent and selective RARγ agonist for the treatment of acne. | 29,706,423 | null |
|
85 | nhr | 1B. Retinoic acid receptors | 592 | Retinoic acid receptor-γ | 2,644 | tretinoin | Metabolite | 6,288 | Agonist | Agonist | true | FDA (1995) | 135,651,435 | true | 9.6 | pKd | 10,129 | Journal | Mol Cell Biol | Activation of retinoid X receptors induces apoptosis in HL-60 cell lines. | 7,791,761 | null | PMC230591 |
85 | nhr | 1B. Retinoic acid receptors | 592 | Retinoic acid receptor-γ | 2,644 | tretinoin | Metabolite | 6,288 | Agonist | Agonist | true | FDA (1995) | 135,651,435 | true | 9.6 | pKd | 10,109 | Journal | Mol Cell Biol | Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping. | 8,264,595 | null | PMC358378 |
85 | nhr | 1B. Retinoic acid receptors | 592 | Retinoic acid receptor-γ | 2,644 | tretinoin | Metabolite | 6,288 | Agonist | Agonist | true | FDA (1995) | 135,651,435 | true | 9.6 | pKd | 10,085 | Journal | Proc Natl Acad Sci USA | Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. | 8,380,496 | null | PMC45593 |
85 | nhr | 1B. Retinoic acid receptors | 592 | Retinoic acid receptor-γ | 2,644 | tretinoin | Metabolite | 6,288 | Agonist | Agonist | true | FDA (1995) | 135,651,435 | true | 9.6 | pKd | 10,144 | Journal | Curr Pharm Des | Therapeutic applications for ligands of retinoid receptors. | 10,637,371 | null | null |
85 | nhr | 1B. Retinoic acid receptors | 592 | Retinoic acid receptor-γ | 2,644 | tretinoin | Metabolite | 6,288 | Agonist | Agonist | true | FDA (1995) | 135,651,435 | true | 9.6 | pKd | 10,110 | Journal | J Mol Biol | Structural basis for isotype selectivity of the human retinoic acid nuclear receptor. | 10,964,567 | null | null |
85 | nhr | 1B. Retinoic acid receptors | 592 | Retinoic acid receptor-γ | 2,644 | tretinoin | Metabolite | 79,008 | Agonist | Agonist | true | FDA (1995) | 135,651,435 | true | 9.7 | pEC50 | 23,508 | Journal | Bioorg Med Chem Lett | Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives. | 19,058,965 | null | null |
85 | nhr | 1B. Retinoic acid receptors | 592 | Retinoic acid receptor-γ | 6,952 | tazarotene | Synthetic organic | 79,007 | Agonist | Agonist | true | FDA (1997) | 178,103,534 | true | 7.4 | pEC50 | 23,508 | Journal | Bioorg Med Chem Lett | Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives. | 19,058,965 | null | null |
85 | nhr | 1B. Retinoic acid receptors | 592 | Retinoic acid receptor-γ | 2,648 | tamibarotene | Synthetic organic | 83,086 | Agonist | Agonist | true | 135,649,930 | false | 6.23 | pEC50 | 30,137 | Journal | J Med Chem | Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives. | 20,925,433 | null | null |
|
85 | nhr | 1B. Retinoic acid receptors | 592 | Retinoic acid receptor-γ | 5,383 | [<sup>3</sup>H]9-cis-retinoic acid | Synthetic organic | 80,600 | Agonist | Full agonist | false | 178,102,041 | false | 9.2 | pKd | 10,085 | Journal | Proc Natl Acad Sci USA | Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. | 8,380,496 | null | PMC45593 |
|
85 | nhr | 1B. Retinoic acid receptors | 592 | Retinoic acid receptor-γ | 2,647 | Ro 40-6055 | Synthetic organic | 83,085 | Agonist | Agonist | false | 135,650,917 | false | 7.89 | pEC50 | 23,508 | Journal | Bioorg Med Chem Lett | Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives. | 19,058,965 | null | null |