SL_GENE
stringlengths
3
8
TS_GENE
stringclasses
13 values
TYMS
LKB1
TYMS
NF1
TYMS
NF2
TYMS
PBRM1
TYMS
PTEN
TYMS
TP53
TYMS
TP53BP1
UBE2T
CDH1
UBE2T
LKB1
UBE2T
NF1
UBE2T
NF2
UBE2T
PBRM1
UBE2T
TP53BP1
BRIP1
LKB1
BRIP1
NF1
BRIP1
NF2
BRIP1
PBRM1
BRIP1
VHL
DDX19A
ARID1A
DDX19A
CDH1
DDX19A
NF2
DDX19A
PBRM1
DDX19A
RB1
PPP2R3C
CDH1
PPP2R3C
LKB1
PPP2R3C
NF2
PPP2R3C
RB1
PPP2R3C
VHL
RPRD1B
LKB1
RPRD1B
NF1
RPRD1B
PTEN
RPRD1B
TP53
RPRD1B
VHL
BPTF
ARID1A
BPTF
KEAP1
BPTF
PBRM1
BPTF
TP53
FANCA
LKB1
FANCA
NF2
FANCA
PBRM1
FANCA
VHL
FANCD2
CDH1
FANCD2
NF2
FANCD2
PBRM1
FANCD2
TP53BP1
FANCF
CDH1
FANCF
LKB1
FANCF
NF2
FANCF
PBRM1
MCM9
LKB1
MCM9
NF2
MCM9
VHL
MCM9
TP53BP1
SDHB
BAP1
SDHB
LKB1
SDHB
PBRM1
SDHB
VHL
USPL1
BAP1
USPL1
NF2
USPL1
PTEN
USPL1
TP53BP1
ATG9A
LKB1
ATG9A
NF1
ATG9A
VHL
C16orf72
ARID1A
C16orf72
BAP1
C16orf72
NF1
COQ2
BAP1
COQ2
KEAP1
COQ2
RB1
FAM106A
LKB1
FAM106A
NF1
FAM106A
PTEN
FBXW11
LKB1
FBXW11
NF1
FBXW11
VHL
NDUFC1
NF1
NDUFC1
PBRM1
NDUFC1
PTEN
PMVK
BAP1
PMVK
NF1
PMVK
NF2
PRDX1
NF1
PRDX1
NF2
PRDX1
PBRM1
PRKRA
LKB1
PRKRA
NF1
PRKRA
VHL
SLC25A33
LKB1
SLC25A33
VHL
SLC25A33
TP53BP1
UIMC1
CDH1
UIMC1
KEAP1
UIMC1
NF1
UMPS
PBRM1
UMPS
RB1
UMPS
VHL
ARID2
LKB1
ARID2
NF2
BIRC6
LKB1

Dataset Description

The SL_GENE_PAIRS dataset provides a curated collection of synthetic lethal (SL) gene pairs and their associated tumor suppressor (TS) genes. This dataset is designed to facilitate research in synthetic lethality, cancer biology, and computational genomics.

Features

  • SL_GENE: The synthetic lethal gene in the pair. Synthetic lethality occurs when the simultaneous disruption of this gene and the associated tumor suppressor gene results in cell death, making it a potential therapeutic target.
  • TS_GENE: The tumor suppressor gene paired with the synthetic lethal gene. Tumor suppressor genes are often mutated or inactivated in cancer, and their synthetic lethal partners can be exploited for targeted therapies.

Dataset Details

  • Number of Records: 209
  • Splits:
    • Train: 209 examples
  • Size:
    • Dataset Size: 3,596 bytes
    • Download Size: 2,207 bytes

Potential Use Cases

  • Cancer Research: Identify gene pairs that can be leveraged for targeted therapies, particularly in cancers with specific tumor suppressor gene mutations.
  • Drug Discovery: Support drug screening efforts to identify inhibitors for synthetic lethal genes in cancer cells.
  • Synthetic Lethality Prediction Models: Provide labeled data for training machine learning models to predict novel synthetic lethal interactions.

Example Queries

  • Identify SL genes associated with common TS genes such as TP53.
  • Explore gene pairs for rare cancers where specific tumor suppressors are frequently inactivated.
  • Train predictive models for synthetic lethality using this dataset.

Citation

If you use this dataset, please cite it as follows:

@dataset{dwb2023_sl_gene_pairs,
  author = {dwb2023},
  title = {Synthetic Lethal Gene Pairs Dataset},
  year = {2025},
  publisher = {Hugging Face Datasets},
  url = {https://huggingface.co/datasets/dwb2023/sl_gene_pairs}
}

Acknowledgements

The dataset was curated using publicly available resources on synthetic lethality and tumor suppressor genes. It is designed to support academic and industrial research in cancer genomics.

License

This dataset is distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license. Ensure proper attribution when using this dataset.

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