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1.0alpha7.train.71
5626303
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1.0alpha7.train.72
12634030
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1.0alpha7.train.73
3367578
[ { "id": "1.0alpha7.train.73.sent", "type": "sentence", "text": [ "Competition and co-immunoprecipitation experiments demonstrated that the binding of TnT to Tm was cooperative in the absence of F-actin." ], "offsets": [ [ 0, 136 ] ] } ]
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1.0alpha7.train.74
23084493
[ { "id": "1.0alpha7.train.74.sent", "type": "sentence", "text": [ "Amagai M, Karpati S, Prussick R, Klaus-Kovtun V, Stanley JR (1992) Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic." ], "offsets": [ [ 0, 183 ] ] } ]
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[]
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[]
1.0alpha7.train.75
24177
[ { "id": "1.0alpha7.train.75.sent", "type": "sentence", "text": [ "Inhibin also binds to ActRII through its beta subunit, competes with the binding of activin to ActRII, but fails to form the ActRII SKR2 complex." ], "offsets": [ [ 0, 145 ] ] } ]
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1.0alpha7.train.76
22450950
[ { "id": "1.0alpha7.train.76.sent", "type": "sentence", "text": [ "These results demonstrate that Sp1 and Sp3 can both bind to the Sp1 consensus sequence in the IGF-II promoter." ], "offsets": [ [ 0, 110 ] ] } ]
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1.0alpha7.train.77
15810883
[ { "id": "1.0alpha7.train.77.sent", "type": "sentence", "text": [ "Recently, U2AF35 has been shown to be able to directly assist U2AF65 binding to Py tracts ( 25)." ], "offsets": [ [ 0, 96 ] ] } ]
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1.0alpha7.train.78
1778453
[ { "id": "1.0alpha7.train.78.sent", "type": "sentence", "text": [ "Characterization of IP4 binding to GST-STII-C2B and GST-STIII-C2Bα-loopβ7-8." ], "offsets": [ [ 0, 76 ] ] } ]
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[]
1.0alpha7.train.79
15268259
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1.0alpha7.train.80
4598555
[ { "id": "1.0alpha7.train.80.sent", "type": "sentence", "text": [ "We have found that full-length recombinant yeast TAF130p does not form a stable ternary complex with yeast TBP bound to TATA DNA and consequently does not actively dissociate the TBP-DNA complex; rather, full-length TAF130p binds to TBP competitively with respect to DNA." ], "offsets": [ [ 0, 271 ] ] } ]
[ { "id": "1.0alpha7.train.80.ent0_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 125, 128 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.80.ent1_1", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 183, 186 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.80.ent2_2", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 267, 270 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.80.ent3_0", "type": "protein", "text": [ "TBP" ], "offsets": [ [ 107, 110 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6908" }, { "db_name": "hgnc", "db_id": "TBP" }, { "db_name": "uniprot", "db_id": "P20226" } ] }, { "id": "1.0alpha7.train.80.ent4_1", "type": "protein", "text": [ "TBP" ], "offsets": [ [ 179, 182 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6908" }, { "db_name": "hgnc", "db_id": "TBP" }, { "db_name": "uniprot", "db_id": "P20226" } ] }, { "id": "1.0alpha7.train.80.ent5_2", "type": "protein", "text": [ "TBP" ], "offsets": [ [ 233, 236 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6908" }, { "db_name": "hgnc", "db_id": "TBP" }, { "db_name": "uniprot", "db_id": "P20226" } ] }, { "id": "1.0alpha7.train.80.ent6_0", "type": "protein", "text": [ "TAF130p" ], "offsets": [ [ 49, 56 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P46677" } ] }, { "id": "1.0alpha7.train.80.ent7_1", "type": "protein", "text": [ "TAF130p" ], "offsets": [ [ 216, 223 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P46677" } ] }, { "id": "1.0alpha7.train.80.ent8_0", "type": "DNA", "text": [ "TATA" ], "offsets": [ [ 120, 124 ] ], "normalized": [] }, { "id": "1.0alpha7.train.80.ent9_0", "type": "protein-complex", "text": [ "TBP-DNA" ], "offsets": [ [ 179, 186 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.81
11949602
[ { "id": "1.0alpha7.train.81.sent", "type": "sentence", "text": [ "In summary, the Dfd homeodomain binds to Exd in vitro, but the Dfd activation domain does not interact in vitro with either the Dfd homeodomain or Exd." ], "offsets": [ [ 0, 151 ] ] } ]
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[]
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1.0alpha7.train.82
5002246
[ { "id": "1.0alpha7.train.82.sent", "type": "sentence", "text": [ "D, Scatchard plots for TNP-ATP binding to MBP 6.2Cdelta36 at pH of 7.5 ( squares) and 6.5 ( diamonds)." ], "offsets": [ [ 0, 102 ] ] } ]
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[]
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1.0alpha7.train.83
8934428
[ { "id": "1.0alpha7.train.83.sent", "type": "sentence", "text": [ "The finding that Plexins can bind Semaphorins, combined with previous studies showing that Plexins can bind Plexins (Ohta et al. 1995), raises questions of whether some Semaphorins might bind one another and whether class I Semaphorins might also function as receptors." ], "offsets": [ [ 0, 269 ] ] } ]
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[]
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"bind", "arg1_id": "1.0alpha7.train.83.ent4_1", "arg2_id": "1.0alpha7.train.83.ent5_2", "normalized": [] }, { "id": "1.0alpha7.train.83.rel1s1.0alpha7.train.83.ent5_2.o1.0alpha7.train.83.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.83.ent5_2", "arg2_id": "1.0alpha7.train.83.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.83.rel1s1.0alpha7.train.83.ent5_2.o1.0alpha7.train.83.ent4_1", "type": "bind", "arg1_id": "1.0alpha7.train.83.ent5_2", "arg2_id": "1.0alpha7.train.83.ent4_1", "normalized": [] }, { "id": "1.0alpha7.train.83.rel1s1.0alpha7.train.83.ent5_2.o1.0alpha7.train.83.ent5_2", "type": "bind", "arg1_id": "1.0alpha7.train.83.ent5_2", "arg2_id": "1.0alpha7.train.83.ent5_2", "normalized": [] }, { "id": "1.0alpha7.train.83.rel2s1.0alpha7.train.83.ent0_0.o1.0alpha7.train.83.ent0_0", "type": "bind", "arg1_id": "1.0alpha7.train.83.ent0_0", "arg2_id": "1.0alpha7.train.83.ent0_0", "normalized": [] }, { "id": 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"normalized": [] }, { "id": "1.0alpha7.train.83.rel2s1.0alpha7.train.83.ent2_2.o1.0alpha7.train.83.ent0_0", "type": "bind", "arg1_id": "1.0alpha7.train.83.ent2_2", "arg2_id": "1.0alpha7.train.83.ent0_0", "normalized": [] }, { "id": "1.0alpha7.train.83.rel2s1.0alpha7.train.83.ent2_2.o1.0alpha7.train.83.ent1_1", "type": "bind", "arg1_id": "1.0alpha7.train.83.ent2_2", "arg2_id": "1.0alpha7.train.83.ent1_1", "normalized": [] }, { "id": "1.0alpha7.train.83.rel2s1.0alpha7.train.83.ent2_2.o1.0alpha7.train.83.ent2_2", "type": "bind", "arg1_id": "1.0alpha7.train.83.ent2_2", "arg2_id": "1.0alpha7.train.83.ent2_2", "normalized": [] } ]
1.0alpha7.train.84
9849106
[ { "id": "1.0alpha7.train.84.sent", "type": "sentence", "text": [ "To test whether p97 binds phosphorylated p47, p97 and p47 were incubated in the presence of Cdc2 and [gamma-32] ATP ( Fig. 3 A)." ], "offsets": [ [ 0, 128 ] ] } ]
[ { "id": "1.0alpha7.train.84.ent0_0", "type": "protein", "text": [ "p47" ], "offsets": [ [ 41, 44 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "55968" }, { "db_name": "hgnc", "db_id": "NSFL1C" }, { "db_name": "uniprot", "db_id": "Q9UNZ2" } ] }, { "id": "1.0alpha7.train.84.ent1_1", "type": "protein", "text": [ "p47" ], "offsets": [ [ 54, 57 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "55968" }, { "db_name": "hgnc", "db_id": "NSFL1C" }, { "db_name": "uniprot", "db_id": "Q9UNZ2" } ] }, { "id": "1.0alpha7.train.84.ent2_0", "type": "protein", "text": [ "Cdc2" ], "offsets": [ [ 92, 96 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "983" }, { "db_name": "hgnc", "db_id": "CDK1" }, { "db_name": "uniprot", "db_id": "P06493" } ] }, { "id": "1.0alpha7.train.84.ent3_0", "type": "protein", "text": [ "phosphorylated p47" ], "offsets": [ [ 26, 44 ] ], "normalized": [] }, { "id": "1.0alpha7.train.84.ent4_0", "type": "chemical", "text": [ "ATP" ], "offsets": [ [ 112, 115 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5957" } ] }, { "id": "1.0alpha7.train.84.ent5_0", "type": "protein", "text": [ "p97" ], "offsets": [ [ 16, 19 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7415" }, { "db_name": "hgnc", "db_id": "VCP" }, { "db_name": "uniprot", "db_id": "P55072" } ] }, { "id": "1.0alpha7.train.84.ent6_1", "type": "protein", "text": [ "p97" ], "offsets": [ [ 46, 49 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7415" }, { "db_name": "hgnc", "db_id": "VCP" }, { "db_name": "uniprot", "db_id": "P55072" } ] } ]
[]
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1.0alpha7.train.85
2164892
[ { "id": "1.0alpha7.train.85.sent", "type": "sentence", "text": [ "In contrast, the binding of Diva to Apaf-1 was not significantly affected by Bcl-XL (Fig. 8 A)." ], "offsets": [ [ 0, 95 ] ] } ]
[ { "id": "1.0alpha7.train.85.ent0_0", "type": "protein", "text": [ "Apaf-1" ], "offsets": [ [ 36, 42 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "317" }, { "db_name": "hgnc", "db_id": "APAF1" }, { "db_name": "uniprot", "db_id": "O14727" } ] }, { "id": "1.0alpha7.train.85.ent1_0", "type": "protein", "text": [ "Bcl-XL" ], "offsets": [ [ 77, 83 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "598" }, { "db_name": "hgnc", "db_id": "BCL2L1" }, { "db_name": "uniprot", "db_id": "Q07817" } ] }, { "id": "1.0alpha7.train.85.ent2_0", "type": "protein", "text": [ "Diva" ], "offsets": [ [ 28, 32 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "10017" }, { "db_name": "hgnc", "db_id": "BCL2L10" }, { "db_name": "uniprot", "db_id": "H0YMD5" } ] } ]
[]
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1.0alpha7.train.86
3548985
[ { "id": "1.0alpha7.train.86.sent", "type": "sentence", "text": [ "Triton X-100 extracts from a crude rat brain nuclear fraction was incubated with GST or GST-GBR1, and protein binding to the fusion proteins was recovered by adding glutathione beads." ], "offsets": [ [ 0, 183 ] ] } ]
[ { "id": "1.0alpha7.train.86.ent0_0", "type": "chemical", "text": [ "Triton X-100" ], "offsets": [ [ 0, 12 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5590" } ] }, { "id": "1.0alpha7.train.86.ent1_0", "type": "protein", "text": [ "GBR1" ], "offsets": [ [ 92, 96 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2550" }, { "db_name": "hgnc", "db_id": "GABBR1" }, { "db_name": "uniprot", "db_id": "Q9UBS5" } ] }, { "id": "1.0alpha7.train.86.ent2_0", "type": "experimental-construct", "text": [ "GST-GBR1" ], "offsets": [ [ 88, 96 ] ], "normalized": [] }, { "id": "1.0alpha7.train.86.ent3_0", "type": "experiment-tag", "text": [ "GST" ], "offsets": [ [ 81, 84 ] ], "normalized": [ { "db_name": "intenz", "db_id": "2.5.1.18" } ] }, { "id": "1.0alpha7.train.86.ent4_1", "type": "experiment-tag", "text": [ "GST" ], "offsets": [ [ 88, 91 ] ], "normalized": [ { "db_name": "intenz", "db_id": "2.5.1.18" } ] }, { "id": "1.0alpha7.train.86.ent5_0", "type": "chemical", "text": [ "glutathione" ], "offsets": [ [ 165, 176 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "124886" } ] } ]
[]
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[]
1.0alpha7.train.87
11828384
[ { "id": "1.0alpha7.train.87.sent", "type": "sentence", "text": [ "It is noteworthy that GSK-3beta bound to beta-catenin only when FWD1 was co-transfected (Figure 3A, lane 2)." ], "offsets": [ [ 0, 108 ] ] } ]
[ { "id": "1.0alpha7.train.87.ent0_0", "type": "protein", "text": [ "beta-catenin" ], "offsets": [ [ 41, 53 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1499" }, { "db_name": "hgnc", "db_id": "CTNNB1" }, { "db_name": "uniprot", "db_id": "P35222" } ] }, { "id": "1.0alpha7.train.87.ent1_0", "type": "protein", "text": [ "GSK-3beta" ], "offsets": [ [ 22, 31 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2932" }, { "db_name": "hgnc", "db_id": "GSK3B" }, { "db_name": "uniprot", "db_id": "P49841" } ] }, { "id": "1.0alpha7.train.87.ent2_0", "type": "protein", "text": [ "FWD1" ], "offsets": [ [ 64, 68 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8945" }, { "db_name": "hgnc", "db_id": "BTRC" }, { "db_name": "uniprot", "db_id": "Q9Y297" } ] } ]
[]
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1.0alpha7.train.88
2450060
[ { "id": "1.0alpha7.train.88.sent", "type": "sentence", "text": [ "A mutant form of Pyk2 (Pyk2-Y402F) that is unable to bind and activate Src is impaired in its ability to induce association of Grb2 with Shc, binding of Crk to p130Cas and stimulation of the ERK and JNK cascades." ], "offsets": [ [ 0, 212 ] ] } ]
[ { "id": "1.0alpha7.train.88.ent0_0", "type": "protein", "text": [ "Src" ], "offsets": [ [ 71, 74 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6714" }, { "db_name": "hgnc", "db_id": "SRC" }, { "db_name": "uniprot", "db_id": "P12931" } ] }, { "id": "1.0alpha7.train.88.ent1_0", "type": "protein", "text": [ "Pyk2" ], "offsets": [ [ 17, 21 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2185" }, { "db_name": "hgnc", "db_id": "PTK2B" }, { "db_name": "uniprot", "db_id": "Q14289" } ] }, { "id": "1.0alpha7.train.88.ent2_1", "type": "protein", "text": [ "Pyk2" ], "offsets": [ [ 23, 27 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2185" }, { "db_name": "hgnc", "db_id": "PTK2B" }, { "db_name": "uniprot", "db_id": "Q14289" } ] }, { "id": "1.0alpha7.train.88.ent3_0", "type": "protein", "text": [ "p130Cas" ], "offsets": [ [ 160, 167 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "9564" }, { "db_name": "hgnc", "db_id": "BCAR1" }, { "db_name": "uniprot", "db_id": "P56945" } ] }, { "id": "1.0alpha7.train.88.ent4_0", "type": "protein", "text": [ "Grb2" ], "offsets": [ [ 127, 131 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2885" }, { "db_name": "hgnc", "db_id": "GRB2" }, { "db_name": "uniprot", "db_id": "P62993" } ] }, { "id": "1.0alpha7.train.88.ent5_0", "type": "protein", "text": [ "Shc" ], "offsets": [ [ 137, 140 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6464" }, { "db_name": "hgnc", "db_id": "SHC1" }, { "db_name": "uniprot", "db_id": "P29353" } ] }, { "id": "1.0alpha7.train.88.ent6_0", "type": "protein", "text": [ "Pyk2-Y402F" ], "offsets": [ [ 23, 33 ] ], "normalized": [] }, { "id": "1.0alpha7.train.88.ent7_0", "type": "protein-family", "text": [ "JNK" ], "offsets": [ [ 199, 202 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR008351" } ] }, { "id": "1.0alpha7.train.88.ent8_0", "type": "protein", "text": [ "Crk" ], "offsets": [ [ 153, 156 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1398" }, { "db_name": "hgnc", "db_id": "CRK" }, { "db_name": "uniprot", "db_id": "P46108" } ] }, { "id": "1.0alpha7.train.88.ent9_0", "type": "protein-family", "text": [ "ERK" ], "offsets": [ [ 191, 194 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.89
8949357
[ { "id": "1.0alpha7.train.89.sent", "type": "sentence", "text": [ "These results indicate that LIN-7 binds to LIN-2 and that LIN-2 binds to LIN-10 in vivo." ], "offsets": [ [ 0, 88 ] ] } ]
[ { "id": "1.0alpha7.train.89.ent0_0", "type": "protein", "text": [ "LIN-7" ], "offsets": [ [ 28, 33 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8825" }, { "db_name": "hgnc", "db_id": "LIN7A" }, { "db_name": "uniprot", "db_id": "O14910" } ] }, { "id": "1.0alpha7.train.89.ent1_0", "type": "protein", "text": [ "LIN-2" ], "offsets": [ [ 43, 48 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8573" }, { "db_name": "hgnc", "db_id": "CASK" }, { "db_name": "uniprot", "db_id": "O14936" } ] }, { "id": "1.0alpha7.train.89.ent2_1", "type": "protein", "text": [ "LIN-2" ], "offsets": [ [ 58, 63 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8573" }, { "db_name": "hgnc", "db_id": "CASK" }, { "db_name": "uniprot", "db_id": "O14936" } ] }, { "id": "1.0alpha7.train.89.ent3_0", "type": "protein", "text": [ "LIN-10" ], "offsets": [ [ 73, 79 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "80262" }, { "db_name": "hgnc", "db_id": "C16orf70" }, { "db_name": "uniprot", "db_id": "Q9BSU1" } ] } ]
[]
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1.0alpha7.train.90
24605299
[ { "id": "1.0alpha7.train.90.sent", "type": "sentence", "text": [ "Binding of GMP to the GK domain of PSD-95 did not induce large conformational changes in the nucleoside binding domain, in contrast to yeast guanylate kinase (Blaszczyk et al., 2001 )." ], "offsets": [ [ 0, 184 ] ] } ]
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[]
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1.0alpha7.train.91
305922
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[]
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[]
1.0alpha7.train.92
1570410
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[]
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1.0alpha7.train.93
25350899
[ { "id": "1.0alpha7.train.93.sent", "type": "sentence", "text": [ "ADF/ cofilin can directly bind to actin filaments and promote their disassembly (Carlier et al., 1999 ; Bamburg, 1999 )." ], "offsets": [ [ 0, 120 ] ] } ]
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[]
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1.0alpha7.train.94
1653458
[ { "id": "1.0alpha7.train.94.sent", "type": "sentence", "text": [ "We expressed both S11 and HMM-like fragments of myosin, and assessed their function, using steady state ATPase assays, stopped flow measurements of the rate of ADP release from myosin bound to actin, and the rate of actin filament sliding in an in vitro motility assay." ], "offsets": [ [ 0, 269 ] ] } ]
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[]
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1.0alpha7.train.95
332387
[ { "id": "1.0alpha7.train.95.sent", "type": "sentence", "text": [ " In contrast, the Rb-binding domain of the transcriptional regulatory protein E2F possesses neither the viral protein homology nor the LxCxE motif, but E2F also binds the hypophosphorylated form of Rb( 12, 13, 14, 15) . " ], "offsets": [ [ 0, 233 ] ] } ]
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[]
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1.0alpha7.train.96
763829
[ { "id": "1.0alpha7.train.96.sent", "type": "sentence", "text": [ "EMSA competition experiments support the hypothesis that CDP binding to the gp91 phox promoter is mutually exclusive with that of transcriptional activating factors (Figs. 4 and 5)." ], "offsets": [ [ 0, 181 ] ] } ]
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[]
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1.0alpha7.train.97
2692931
[ { "id": "1.0alpha7.train.97.sent", "type": "sentence", "text": [ "We have found that the armadillo repeats 2-7 of plakoglobin bind to Axin." ], "offsets": [ [ 0, 73 ] ] } ]
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[]
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1.0alpha7.train.98
2589974
[ { "id": "1.0alpha7.train.98.sent", "type": "sentence", "text": [ "This is contrary to what one would expect if high ionic strength decreases the effect of the mutation on the binding of the regulatory complex to actin." ], "offsets": [ [ 0, 152 ] ] } ]
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[]
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[]
1.0alpha7.train.99
9239384
[ { "id": "1.0alpha7.train.99.sent", "type": "sentence", "text": [ "Biochemical experiments revealed that the binding of SXL to the pre-mRNA does not displace SPF45." ], "offsets": [ [ 0, 97 ] ] } ]
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[]
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1.0alpha7.train.100
5566553
[ { "id": "1.0alpha7.train.100.sent", "type": "sentence", "text": [ "In this study, I examined the Rab binding activities of Rim1, Rim2, Noc2, and rabphilin by cotransfection assay in COS-7 cells using 42 different Rab proteins (including 37 subfamilies reported in the mouse data bases (18, 19)) and found that these molecules exhibit distinct Rab binding specificity. " ], "offsets": [ [ 0, 301 ] ] } ]
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[]
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1.0alpha7.train.101
1084839
[ { "id": "1.0alpha7.train.101.sent", "type": "sentence", "text": [ "Alternatively, auxilin might bind much more weakly to Hsc70 in ADP than ATP." ], "offsets": [ [ 0, 76 ] ] } ]
[ { "id": "1.0alpha7.train.101.ent0_0", "type": "chemical", "text": [ "ATP" ], "offsets": [ [ 72, 75 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5957" } ] }, { "id": "1.0alpha7.train.101.ent1_0", "type": "chemical", "text": [ "ADP" ], "offsets": [ [ 63, 66 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "6022" } ] }, { "id": "1.0alpha7.train.101.ent2_0", "type": "protein", "text": [ "Hsc70" ], "offsets": [ [ 54, 59 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3312" }, { "db_name": "hgnc", "db_id": "HSPA8" }, { "db_name": "uniprot", "db_id": "P11142" } ] }, { "id": "1.0alpha7.train.101.ent3_0", "type": "protein", "text": [ "auxilin" ], "offsets": [ [ 15, 22 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "9829" }, { "db_name": "hgnc", "db_id": "DNAJC6" }, { "db_name": "uniprot", "db_id": "O75061" } ] } ]
[]
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1.0alpha7.train.102
11274680
[ { "id": "1.0alpha7.train.102.sent", "type": "sentence", "text": [ "However, these mutations greatly diminished (G423A) or abolished (Y426A and RQ428, 429AA) Smad2 binding to the TGF‐β receptor complex (Table I)." ], "offsets": [ [ 0, 144 ] ] } ]
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[]
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1.0alpha7.train.103
11376780
[ { "id": "1.0alpha7.train.103.sent", "type": "sentence", "text": [ "Like its yeast counterpart, purified human SWI-SNF complex contains ATP-dependent nucleosome disruption activity that leads to facilitated binding of TBP and Gal4 derivatives to synthetic promoters (Imbalzano et al., 1994 ; Kwon et al., 1994)." ], "offsets": [ [ 0, 252 ] ] } ]
[ { "id": "1.0alpha7.train.103.ent0_0", "type": "protein-complex", "text": [ "SWI-SNF" ], "offsets": [ [ 45, 52 ] ], "normalized": [] }, { "id": "1.0alpha7.train.103.ent1_0", "type": "protein", "text": [ "TBP" ], "offsets": [ [ 154, 157 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6908" }, { "db_name": "hgnc", "db_id": "TBP" }, { "db_name": "uniprot", "db_id": "P20226" } ] }, { "id": "1.0alpha7.train.103.ent2_0", "type": "protein", "text": [ "Gal4" ], "offsets": [ [ 163, 167 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3960" }, { "db_name": "hgnc", "db_id": "LGALS4" }, { "db_name": "uniprot", "db_id": "P56470" } ] }, { "id": "1.0alpha7.train.103.ent3_0", "type": "chemical", "text": [ "ATP" ], "offsets": [ [ 71, 74 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5957" } ] } ]
[]
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[]
1.0alpha7.train.104
22557001
[ { "id": "1.0alpha7.train.104.sent", "type": "sentence", "text": [ "The inability of tyrosine-phosphorylated SLP-76 to interact with nck(SH2*) was not due to a gross conformational change induced by the R308K mutation, as nck(SH2*) still bound cbl, an interaction that is mediated through the N-terminal SH3 domain of nck (bottom panel) (Rivero-Lezcano et al. 1994). " ], "offsets": [ [ 0, 299 ] ] } ]
[ { "id": "1.0alpha7.train.104.ent0_0", "type": "protein", "text": [ "cbl" ], "offsets": [ [ 176, 179 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "867" }, { "db_name": "hgnc", "db_id": "CBL" }, { "db_name": "uniprot", "db_id": "P22681" } ] }, { "id": "1.0alpha7.train.104.ent1_0", "type": "protein", "text": [ "nck" ], "offsets": [ [ 65, 68 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4690" }, { "db_name": "hgnc", "db_id": "NCK1" }, { "db_name": "uniprot", "db_id": "P16333" } ] }, { "id": "1.0alpha7.train.104.ent2_1", "type": "protein", "text": [ "nck" ], "offsets": [ [ 154, 157 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4690" }, { "db_name": "hgnc", "db_id": "NCK1" }, { "db_name": "uniprot", "db_id": "P16333" } ] }, { "id": "1.0alpha7.train.104.ent3_2", "type": "protein", "text": [ "nck" ], "offsets": [ [ 250, 253 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4690" }, { "db_name": "hgnc", "db_id": "NCK1" }, { "db_name": "uniprot", "db_id": "P16333" } ] }, { "id": "1.0alpha7.train.104.ent4_0", "type": "protein", "text": [ "nck(SH2*)" ], "offsets": [ [ 65, 74 ] ], "normalized": [] }, { "id": "1.0alpha7.train.104.ent5_1", "type": "protein", "text": [ "nck(SH2*)" ], "offsets": [ [ 154, 163 ] ], "normalized": [] }, { "id": "1.0alpha7.train.104.ent6_0", "type": "protein", "text": [ "SLP-76" ], "offsets": [ [ 41, 47 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3937" }, { "db_name": "hgnc", "db_id": "LCP2" }, { "db_name": "uniprot", "db_id": "Q13094" } ] }, { "id": "1.0alpha7.train.104.ent7_0", "type": "protein-domain", "text": [ "SH3 domain" ], "offsets": [ [ 236, 246 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR001452" } ] } ]
[]
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1.0alpha7.train.105
3584765
[ { "id": "1.0alpha7.train.105.sent", "type": "sentence", "text": [ " Since Dvl-1 also binds directly to this region of Axin ( 26), we examined whether Dvl and Axam share the same binding site on Axin. " ], "offsets": [ [ 0, 139 ] ] } ]
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1.0alpha7.train.106
8936681
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1.0alpha7.train.107
11491342
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1.0alpha7.train.108
12455441
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1.0alpha7.train.109
11778392
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[]
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1.0alpha7.train.110
4164520
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1.0alpha7.train.111
22482077
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[]
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1.0alpha7.train.112
12612407
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1.0alpha7.train.113
2191110
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[]
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1.0alpha7.train.114
9486072
[ { "id": "1.0alpha7.train.114.sent", "type": "sentence", "text": [ "Cortactin Binds the Arp2/3 Complex through Sequences in the NTA Region" ], "offsets": [ [ 0, 70 ] ] } ]
[ { "id": "1.0alpha7.train.114.ent0_0", "type": "protein-motif", "text": [ "NTA" ], "offsets": [ [ 60, 63 ] ], "normalized": [] }, { "id": "1.0alpha7.train.114.ent1_0", "type": "protein", "text": [ "Cortactin" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2017" }, { "db_name": "hgnc", "db_id": "CTTN" }, { "db_name": "uniprot", "db_id": "Q14247" } ] }, { "id": "1.0alpha7.train.114.ent2_0", "type": "protein-complex", "text": [ "Arp2/3" ], "offsets": [ [ 20, 26 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.116
3218892
[ { "id": "1.0alpha7.train.116.sent", "type": "sentence", "text": [ "This value, which can also be deduced from the HPLC elution pattern after calibration with standard proteins of known Stokes radii (Figs. 5 A and 6 A, 5.5 ± 0.3 nm), is identical to that for ATPase in C12E8 (22) (the sedimentation coefficient for Ca2+-ATPase monomers in DM is larger than that for Ca2+-ATPase monomers in C12E8, 7.62 S (this work) versus 5.1 S (45), mainly because DM is more dense than C12E8 (DM has a partial specific volume smaller than that of C12E8, 0.82 (Ref.46) versus 0.97 cm3/g (Ref. 23)), and also because the protein binds slightly more (23) DM than C12E8)." ], "offsets": [ [ 0, 585 ] ] } ]
[ { "id": "1.0alpha7.train.116.ent0_0", "type": "protein-family", "text": [ "ATPase" ], "offsets": [ [ 191, 197 ] ], "normalized": [] }, { "id": "1.0alpha7.train.116.ent1_1", "type": "protein-family", "text": [ "ATPase" ], "offsets": [ [ 252, 258 ] ], "normalized": [] }, { "id": "1.0alpha7.train.116.ent2_2", "type": "protein-family", "text": [ "ATPase" ], "offsets": [ [ 303, 309 ] ], "normalized": [] }, { "id": "1.0alpha7.train.116.ent3_0", "type": "chemical", "text": [ "C12E8" ], "offsets": [ [ 201, 206 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "123921" } ] }, { "id": "1.0alpha7.train.116.ent4_1", "type": "chemical", "text": [ "C12E8" ], "offsets": [ [ 322, 327 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "123921" } ] }, { "id": "1.0alpha7.train.116.ent5_2", "type": "chemical", "text": [ "C12E8" ], "offsets": [ [ 404, 409 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "123921" } ] }, { "id": "1.0alpha7.train.116.ent6_3", "type": "chemical", "text": [ "C12E8" ], "offsets": [ [ 465, 470 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "123921" } ] }, { "id": "1.0alpha7.train.116.ent7_4", "type": "chemical", "text": [ "C12E8" ], "offsets": [ [ 578, 583 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "123921" } ] }, { "id": "1.0alpha7.train.116.ent8_0", "type": "assay", "text": [ "HPLC" ], "offsets": [ [ 47, 51 ] ], "normalized": [] }, { "id": "1.0alpha7.train.116.ent9_0", "type": "chemical", "text": [ "DM" ], "offsets": [ [ 271, 273 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "445456" } ] }, { "id": "1.0alpha7.train.116.ent10_1", "type": "chemical", "text": [ "DM" ], "offsets": [ [ 382, 384 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "445456" } ] }, { "id": "1.0alpha7.train.116.ent11_2", "type": "chemical", "text": [ "DM" ], "offsets": [ [ 411, 413 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "445456" } ] }, { "id": "1.0alpha7.train.116.ent12_3", "type": "chemical", "text": [ "DM" ], "offsets": [ [ 570, 572 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "445456" } ] }, { "id": "1.0alpha7.train.116.ent13_0", "type": "protein", "text": [ "Ca2+-ATPase" ], "offsets": [ [ 247, 258 ] ], "normalized": [] }, { "id": "1.0alpha7.train.116.ent14_1", "type": "protein", "text": [ "Ca2+-ATPase" ], "offsets": [ [ 298, 309 ] ], "normalized": [] } ]
[]
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[]
1.0alpha7.train.117
24832606
[ { "id": "1.0alpha7.train.117.sent", "type": "sentence", "text": [ "Comparison of the Kapp values in the absence of agonist versus those in the presence of agonist suggests that CrV binding strongly favors the desensitized conformation of the AChR because this is the conformation stabilized by agonists at equilibrium." ], "offsets": [ [ 0, 251 ] ] } ]
[ { "id": "1.0alpha7.train.117.ent0_0", "type": "chemical", "text": [ "CrV" ], "offsets": [ [ 110, 113 ] ], "normalized": [] }, { "id": "1.0alpha7.train.117.ent1_0", "type": "protein-family", "text": [ "AChR" ], "offsets": [ [ 175, 179 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.118
25596381
[ { "id": "1.0alpha7.train.118.sent", "type": "sentence", "text": [ "A more pronounced increase in [3] GABA binding to Hydra membranes was apparent in the presence of general anaesthetics ( Fig. 1A)." ], "offsets": [ [ 0, 130 ] ] } ]
[ { "id": "1.0alpha7.train.118.ent0_0", "type": "experimental-construct", "text": [ "Hydra membranes" ], "offsets": [ [ 50, 65 ] ], "normalized": [] }, { "id": "1.0alpha7.train.118.ent1_0", "type": "chemical", "text": [ "GABA" ], "offsets": [ [ 34, 38 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "119" } ] } ]
[]
[ { "id": "1.0alpha7.train.118.coref0", "entity_ids": [ "1.0alpha7.train.118.ent0_0" ] }, { "id": "1.0alpha7.train.118.coref1", "entity_ids": [ "1.0alpha7.train.118.ent1_0" ] } ]
[]
1.0alpha7.train.119
20576331
[ { "id": "1.0alpha7.train.119.sent", "type": "sentence", "text": [ "Notably, binding to E-cadherin and APC seems to be mutually exclusive, and β-catenin bound to cadherins in adherens junctions should be therefore inaccessible to APC-mediated degradation. " ], "offsets": [ [ 0, 188 ] ] } ]
[ { "id": "1.0alpha7.train.119.ent0_0", "type": "protein", "text": [ "APC" ], "offsets": [ [ 35, 38 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "324" }, { "db_name": "hgnc", "db_id": "APC" } ] }, { "id": "1.0alpha7.train.119.ent1_1", "type": "protein", "text": [ "APC" ], "offsets": [ [ 162, 165 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "324" }, { "db_name": "hgnc", "db_id": "APC" } ] }, { "id": "1.0alpha7.train.119.ent2_0", "type": "protein-family", "text": [ "cadherins" ], "offsets": [ [ 94, 103 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR039808" } ] }, { "id": "1.0alpha7.train.119.ent3_0", "type": "protein", "text": [ "catenin" ], "offsets": [ [ 77, 84 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1495" }, { "db_name": "hgnc", "db_id": "CTNNA1" }, { "db_name": "uniprot", "db_id": "P35221" } ] }, { "id": "1.0alpha7.train.119.ent4_0", "type": "protein", "text": [ "E-cadherin" ], "offsets": [ [ 20, 30 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "999" }, { "db_name": "hgnc", "db_id": "CDH1" }, { "db_name": "uniprot", "db_id": "P12830" } ] } ]
[]
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1.0alpha7.train.120
864980
[ { "id": "1.0alpha7.train.120.sent", "type": "sentence", "text": [ " It was found to bind to collagen type I, but collagen preincubated in a dot blot assay with heparin did not bind any longerR to APP. " ], "offsets": [ [ 0, 141 ] ] } ]
[ { "id": "1.0alpha7.train.120.ent0_0", "type": "chemical", "text": [ "heparin" ], "offsets": [ [ 98, 105 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "772" } ] }, { "id": "1.0alpha7.train.120.ent1_0", "type": "protein", "text": [ "APP" ], "offsets": [ [ 135, 138 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "351" }, { "db_name": "hgnc", "db_id": "APP" } ] }, { "id": "1.0alpha7.train.120.ent2_0", "type": "protein-complex", "text": [ "collagen" ], "offsets": [ [ 27, 35 ] ], "normalized": [] }, { "id": "1.0alpha7.train.120.ent3_1", "type": "protein-complex", "text": [ "collagen" ], "offsets": [ [ 49, 57 ] ], "normalized": [] }, { "id": "1.0alpha7.train.120.ent4_0", "type": "protein-complex", "text": [ "collagen type I" ], "offsets": [ [ 27, 42 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.121
1559207
[ { "id": "1.0alpha7.train.121.sent", "type": "sentence", "text": [ "JNK/SAPK Binds and Phosphorylates a MEKK1 Fragment In Vitro" ], "offsets": [ [ 0, 59 ] ] } ]
[ { "id": "1.0alpha7.train.121.ent0_0", "type": "protein", "text": [ "JNK" ], "offsets": [ [ 0, 3 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5599" }, { "db_name": "hgnc", "db_id": "MAPK8" }, { "db_name": "uniprot", "db_id": "P45983" } ] }, { "id": "1.0alpha7.train.121.ent1_0", "type": "protein", "text": [ "MEKK1" ], "offsets": [ [ 36, 41 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4214" }, { "db_name": "hgnc", "db_id": "MAP3K1" }, { "db_name": "uniprot", "db_id": "Q13233" } ] }, { "id": "1.0alpha7.train.121.ent2_0", "type": "protein", "text": [ "SAPK" ], "offsets": [ [ 4, 8 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5599" }, { "db_name": "hgnc", "db_id": "MAPK8" }, { "db_name": "uniprot", "db_id": "P45983" } ] } ]
[]
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1.0alpha7.train.122
22450916
[ { "id": "1.0alpha7.train.122.sent", "type": "sentence", "text": [ "Since both of the Sp1 binding sequences (GGGTGG) showed variations of the Sp1 consensus binding sequences (GGGCGG), a single T (m1, m2) and both Ts (m4) of the variant Sp1 sites were changed into C, in order to test the ability of the Sp1 consensus binding (GGGCGG) sequences to confer PTEN-mediated transcriptional regulation (Fig. 2Ba)." ], "offsets": [ [ 0, 338 ] ] } ]
[ { "id": "1.0alpha7.train.122.ent0_0", "type": "protein", "text": [ "PTEN" ], "offsets": [ [ 286, 290 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5728" }, { "db_name": "hgnc", "db_id": "PTEN" }, { "db_name": "uniprot", "db_id": "P60484" } ] }, { "id": "1.0alpha7.train.122.ent1_0", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 18, 21 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.122.ent2_1", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 74, 77 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.122.ent3_2", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 168, 171 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.122.ent4_3", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 235, 238 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.122.ent5_0", "type": "DNA", "text": [ "Sp1 binding sequences" ], "offsets": [ [ 18, 39 ] ], "normalized": [] }, { "id": "1.0alpha7.train.122.ent6_0", "type": "DNA", "text": [ "GGGTGG" ], "offsets": [ [ 41, 47 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.123
3395839
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[]
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1.0alpha7.train.124
1926592
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[]
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1.0alpha7.train.125
15275220
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[]
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1.0alpha7.train.126
2648477
[ { "id": "1.0alpha7.train.126.sent", "type": "sentence", "text": [ "poly( dC)-agarose; lane 3, DADA mutant protein bound to poly( dI)." ], "offsets": [ [ 0, 66 ] ] } ]
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[]
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[]
1.0alpha7.train.127
9285542
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[]
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1.0alpha7.train.128
25266276
[ { "id": "1.0alpha7.train.128.sent", "type": "sentence", "text": [ "Binding of neuroligins to PSD-95." ], "offsets": [ [ 0, 33 ] ] } ]
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[]
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1.0alpha7.train.129
3129111
[ { "id": "1.0alpha7.train.129.sent", "type": "sentence", "text": [ "TFIIA binds directly to TBP and at least one TBP-associated factor (TAF) in the TFIID complex ( 7)." ], "offsets": [ [ 0, 99 ] ] } ]
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[]
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1.0alpha7.train.130
9252666
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[]
[ { "id": "1.0alpha7.train.130.coref0", "entity_ids": [ "1.0alpha7.train.130.ent0_0", "1.0alpha7.train.130.ent1_1" ] }, { "id": "1.0alpha7.train.130.coref1", "entity_ids": [ "1.0alpha7.train.130.ent2_0" ] } ]
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1.0alpha7.train.131
24680614
[ { "id": "1.0alpha7.train.131.sent", "type": "sentence", "text": [ "Control experiments confirmed retention of EGFR binding by the mutant form of c-Cbl." ], "offsets": [ [ 0, 84 ] ] } ]
[ { "id": "1.0alpha7.train.131.ent0_0", "type": "protein", "text": [ "c-Cbl" ], "offsets": [ [ 78, 83 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "867" }, { "db_name": "hgnc", "db_id": "CBL" }, { "db_name": "uniprot", "db_id": "P22681" } ] }, { "id": "1.0alpha7.train.131.ent1_0", "type": "protein", "text": [ "EGFR" ], "offsets": [ [ 43, 47 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1956" }, { "db_name": "hgnc", "db_id": "EGFR" }, { "db_name": "uniprot", "db_id": "P00533" } ] } ]
[]
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1.0alpha7.train.132
4494959
[ { "id": "1.0alpha7.train.132.sent", "type": "sentence", "text": [ "The rate of ADP binding to ( k+AD) and dissociation from ( k AD) actomyosin are too fast to be measured using the method described here." ], "offsets": [ [ 0, 136 ] ] } ]
[ { "id": "1.0alpha7.train.132.ent0_0", "type": "protein-family", "text": [ "actomyosin" ], "offsets": [ [ 65, 75 ] ], "normalized": [] }, { "id": "1.0alpha7.train.132.ent1_0", "type": "chemical", "text": [ "ADP" ], "offsets": [ [ 12, 15 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "6022" } ] } ]
[]
[ { "id": "1.0alpha7.train.132.coref0", "entity_ids": [ "1.0alpha7.train.132.ent0_0" ] }, { "id": "1.0alpha7.train.132.coref1", "entity_ids": [ "1.0alpha7.train.132.ent1_0" ] } ]
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1.0alpha7.train.133
12658341
[ { "id": "1.0alpha7.train.133.sent", "type": "sentence", "text": [ "To verify that U2AF65 bound to the Py tract, we constructed and analyzed Py tract deletion mutants muMPy and muMdeltaPy (see Fig. 1A)." ], "offsets": [ [ 0, 134 ] ] } ]
[ { "id": "1.0alpha7.train.133.ent0_0", "type": "DNA", "text": [ "muMPy" ], "offsets": [ [ 99, 104 ] ], "normalized": [] }, { "id": "1.0alpha7.train.133.ent1_0", "type": "DNA", "text": [ "muMdeltaPy" ], "offsets": [ [ 109, 119 ] ], "normalized": [] }, { "id": "1.0alpha7.train.133.ent2_0", "type": "protein", "text": [ "U2AF65" ], "offsets": [ [ 15, 21 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "11338" }, { "db_name": "hgnc", "db_id": "U2AF2" }, { "db_name": "uniprot", "db_id": "P26368" } ] }, { "id": "1.0alpha7.train.133.ent3_0", "type": "DNA", "text": [ "Py tract" ], "offsets": [ [ 35, 43 ] ], "normalized": [] }, { "id": "1.0alpha7.train.133.ent4_1", "type": "DNA", "text": [ "Py tract" ], "offsets": [ [ 73, 81 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.133.coref0", "entity_ids": [ "1.0alpha7.train.133.ent0_0" ] }, { "id": "1.0alpha7.train.133.coref1", "entity_ids": [ "1.0alpha7.train.133.ent1_0" ] }, { "id": "1.0alpha7.train.133.coref2", "entity_ids": [ "1.0alpha7.train.133.ent2_0" ] }, { "id": "1.0alpha7.train.133.coref3", "entity_ids": [ "1.0alpha7.train.133.ent3_0", "1.0alpha7.train.133.ent4_1" ] } ]
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1.0alpha7.train.134
15268380
[ { "id": "1.0alpha7.train.134.sent", "type": "sentence", "text": [ "To examine whether CRT binds to the SL structure, we tested the interaction of CRT with a short sORF oligomer and with a longer oligomer, FL-LAP, which covers the region of C/EBPβ mRNA from the first (FL) to the second (LAP) AUG codons (Fig. ​(Fig.1)1) (see Materials and Methods)." ], "offsets": [ [ 0, 281 ] ] } ]
[ { "id": "1.0alpha7.train.134.ent0_0", "type": "RNA", "text": [ "AUG" ], "offsets": [ [ 225, 228 ] ], "normalized": [] }, { "id": "1.0alpha7.train.134.ent1_0", "type": "protein", "text": [ "CRT" ], "offsets": [ [ 19, 22 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "811" }, { "db_name": "hgnc", "db_id": "CALR" }, { "db_name": "uniprot", "db_id": "P27797" } ] }, { "id": "1.0alpha7.train.134.ent2_1", "type": "protein", "text": [ "CRT" ], "offsets": [ [ 79, 82 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "811" }, { "db_name": "hgnc", "db_id": "CALR" }, { "db_name": "uniprot", "db_id": "P27797" } ] }, { "id": "1.0alpha7.train.134.ent3_0", "type": "RNA", "text": [ "SL structure" ], "offsets": [ [ 36, 48 ] ], "normalized": [] }, { "id": "1.0alpha7.train.134.ent4_0", "type": "experiment-tag", "text": [ "FL" ], "offsets": [ [ 138, 140 ] ], "normalized": [] }, { "id": "1.0alpha7.train.134.ent5_1", "type": "experiment-tag", "text": [ "FL" ], "offsets": [ [ 201, 203 ] ], "normalized": [] }, { "id": "1.0alpha7.train.134.ent6_0", "type": "experiment-tag", "text": [ "FL-LAP" ], "offsets": [ [ 138, 144 ] ], "normalized": [] }, { "id": "1.0alpha7.train.134.ent7_0", "type": "RNA", "text": [ "C/EBPβ mRNA" ], "offsets": [ [ 173, 184 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1051" }, { "db_name": "hgnc", "db_id": "CEBPB" } ] }, { "id": "1.0alpha7.train.134.ent8_0", "type": "experiment-tag", "text": [ "LAP" ], "offsets": [ [ 141, 144 ] ], "normalized": [] }, { "id": "1.0alpha7.train.134.ent9_1", "type": "experiment-tag", "text": [ "LAP" ], "offsets": [ [ 220, 223 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.134.coref0", "entity_ids": [ "1.0alpha7.train.134.ent0_0" ] }, { "id": "1.0alpha7.train.134.coref1", "entity_ids": [ "1.0alpha7.train.134.ent1_0", "1.0alpha7.train.134.ent2_1" ] }, { "id": "1.0alpha7.train.134.coref2", "entity_ids": [ "1.0alpha7.train.134.ent3_0" ] }, { "id": "1.0alpha7.train.134.coref3", "entity_ids": [ "1.0alpha7.train.134.ent4_0", "1.0alpha7.train.134.ent5_1" ] }, { "id": "1.0alpha7.train.134.coref4", "entity_ids": [ "1.0alpha7.train.134.ent6_0" ] }, { "id": "1.0alpha7.train.134.coref5", "entity_ids": [ "1.0alpha7.train.134.ent7_0" ] }, { "id": "1.0alpha7.train.134.coref6", "entity_ids": [ "1.0alpha7.train.134.ent8_0", "1.0alpha7.train.134.ent9_1" ] } ]
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1.0alpha7.train.135
4211397
[ { "id": "1.0alpha7.train.135.sent", "type": "sentence", "text": [ "NAD(H) binds to dI, and NADP(H) binds to dIII; these two components protrude from the membrane (into the bacterial cytoplasm or mitochondrial matrix)." ], "offsets": [ [ 0, 150 ] ] } ]
[ { "id": "1.0alpha7.train.135.ent0_0", "type": "chemical", "text": [ "NAD(H)" ], "offsets": [ [ 0, 6 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "925" } ] }, { "id": "1.0alpha7.train.135.ent1_0", "type": "chemical", "text": [ "NADP(H)" ], "offsets": [ [ 24, 31 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5885" } ] }, { "id": "1.0alpha7.train.135.ent2_0", "type": "protein-domain", "text": [ "dIII" ], "offsets": [ [ 41, 45 ] ], "normalized": [] }, { "id": "1.0alpha7.train.135.ent3_0", "type": "protein-domain", "text": [ "dI" ], "offsets": [ [ 16, 18 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.135.coref0", "entity_ids": [ "1.0alpha7.train.135.ent0_0" ] }, { "id": "1.0alpha7.train.135.coref1", "entity_ids": [ "1.0alpha7.train.135.ent1_0" ] }, { "id": "1.0alpha7.train.135.coref2", "entity_ids": [ "1.0alpha7.train.135.ent2_0" ] }, { "id": "1.0alpha7.train.135.coref3", "entity_ids": [ "1.0alpha7.train.135.ent3_0" ] } ]
[]
1.0alpha7.train.136
12515287
[ { "id": "1.0alpha7.train.136.sent", "type": "sentence", "text": [ "Aside from TFIID binding to the Inr, it has also been observed that purified RNA polymerase II (or RNA polymerase II along with TBP, TFIIB, TFIIF) is able to recognize the Inr and to mediate transcription in an Inr-dependent manner in the absence of TAFs (Carcamo et al. 1991; Weis and Reinberg 1997)." ], "offsets": [ [ 0, 301 ] ] } ]
[ { "id": "1.0alpha7.train.136.ent0_0", "type": "protein", "text": [ "TFIIB" ], "offsets": [ [ 133, 138 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2959" }, { "db_name": "hgnc", "db_id": "GTF2B" }, { "db_name": "uniprot", "db_id": "Q00403" } ] }, { "id": "1.0alpha7.train.136.ent1_0", "type": "protein-domain", "text": [ "TAFs" ], "offsets": [ [ 250, 254 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR004823" } ] }, { "id": "1.0alpha7.train.136.ent2_0", "type": "protein", "text": [ "TBP" ], "offsets": [ [ 128, 131 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6908" }, { "db_name": "hgnc", "db_id": "TBP" }, { "db_name": "uniprot", "db_id": "P20226" } ] }, { "id": "1.0alpha7.train.136.ent3_0", "type": "DNA", "text": [ "Inr" ], "offsets": [ [ 32, 35 ] ], "normalized": [] }, { "id": "1.0alpha7.train.136.ent4_1", "type": "DNA", "text": [ "Inr" ], "offsets": [ [ 172, 175 ] ], "normalized": [] }, { "id": "1.0alpha7.train.136.ent5_2", "type": "DNA", "text": [ "Inr" ], "offsets": [ [ 211, 214 ] ], "normalized": [] }, { "id": "1.0alpha7.train.136.ent6_0", "type": "protein-complex", "text": [ "RNA polymerase II" ], "offsets": [ [ 77, 94 ] ], "normalized": [] }, { "id": "1.0alpha7.train.136.ent7_1", "type": "protein-complex", "text": [ "RNA polymerase II" ], "offsets": [ [ 99, 116 ] ], "normalized": [] }, { "id": "1.0alpha7.train.136.ent8_0", "type": "protein", "text": [ "TFIID" ], "offsets": [ [ 11, 16 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6908" }, { "db_name": "hgnc", "db_id": "TBP" }, { "db_name": "uniprot", "db_id": "P20226" } ] }, { "id": "1.0alpha7.train.136.ent9_0", "type": "protein", "text": [ "TFIIF" ], "offsets": [ [ 140, 145 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2962" }, { "db_name": "hgnc", "db_id": "GTF2F1" }, { "db_name": "uniprot", "db_id": "P35269" } ] } ]
[]
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1.0alpha7.train.137
11251583
[ { "id": "1.0alpha7.train.137.sent", "type": "sentence", "text": [ "These results confirm the specific interaction with the GTP-bound form of Rab5 observed in the two-hybrid system and indicate that, like Rabaptin-5, Rabaptin-5beta is recruited by Rab5GTP on endosomal membranes in vivo." ], "offsets": [ [ 0, 219 ] ] } ]
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1.0alpha7.train.138
13135266
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[]
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1.0alpha7.train.139
19576446
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[]
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1.0alpha7.train.140
18275217
[ { "id": "1.0alpha7.train.140.sent", "type": "sentence", "text": [ "Binding of HsOrc1 and HsCdc6 to GST was not detectable (lanes 2 and 6), confirming that the interaction was mediated by the HsCdc6 portion of the fusion protein." ], "offsets": [ [ 0, 161 ] ] } ]
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[]
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1.0alpha7.train.141
888168
[ { "id": "1.0alpha7.train.141.sent", "type": "sentence", "text": [ "PKA phosphorylation of adducin reduced activity of adducin in association with spectrin-actin complexes and in promoting binding of spectrin to F-actin." ], "offsets": [ [ 0, 152 ] ] } ]
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[]
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1.0alpha7.train.142
12649879
[ { "id": "1.0alpha7.train.142.sent", "type": "sentence", "text": [ "p23 and Hsp90 bind hTERT." ], "offsets": [ [ 0, 25 ] ] } ]
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[]
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1.0alpha7.train.143
9803938
[ { "id": "1.0alpha7.train.143.sent", "type": "sentence", "text": [ "It is hard to imagine how ADF binding to an actin monomer could increase the rate of its thermally driven collision with a filament end." ], "offsets": [ [ 0, 136 ] ] } ]
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[]
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1.0alpha7.train.144
4786682
[ { "id": "1.0alpha7.train.144.sent", "type": "sentence", "text": [ "Fig. 3 A shows that both the full-length and the amino-terminal p53 fragment binds to CR2 ( lanes 5 and 8)." ], "offsets": [ [ 0, 107 ] ] } ]
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[]
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1.0alpha7.train.145
3410123
[ { "id": "1.0alpha7.train.145.sent", "type": "sentence", "text": [ "Unlike the Sir protein and bromo domain interactions, HP1 binding to H4 tail peptides appears to be unaffected by acetylation." ], "offsets": [ [ 0, 126 ] ] } ]
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[]
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1.0alpha7.train.146
2892590
[ { "id": "1.0alpha7.train.146.sent", "type": "sentence", "text": [ "Additionally, we show here that FKBP52 binds directly to the GR." ], "offsets": [ [ 0, 64 ] ] } ]
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[]
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1.0alpha7.train.147
8964613
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[]
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1.0alpha7.train.148
23474591
[ { "id": "1.0alpha7.train.148.sent", "type": "sentence", "text": [ "In addition, changes to tau also regulated this interaction, as shown by the altered binding of S100β to the AD-related hyperphosphorylated NFT-tau." ], "offsets": [ [ 0, 148 ] ] } ]
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[]
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1.0alpha7.train.149
939722
[ { "id": "1.0alpha7.train.149.sent", "type": "sentence", "text": [ "Tnfr1 and Tnfr2 bind Tnfα and Tnfβ with similar high equilibrium affinity, but they differ significantly in their Tnfα binding kinetics; Tnfα bound to Tnfr2 is exchanged at a significantly faster rate than when complexed with Tnfr1 (9, 10, 11, 12)." ], "offsets": [ [ 0, 248 ] ] } ]
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[]
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1.0alpha7.train.150
19263710
[ { "id": "1.0alpha7.train.150.sent", "type": "sentence", "text": [ "Studies in vitro revealed that both p55 and hDlg bind directly to protein 4.1 [7 ." ], "offsets": [ [ 0, 82 ] ] } ]
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[]
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1.0alpha7.train.151
9838417
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[]
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1.0alpha7.train.152
19831892
[ { "id": "1.0alpha7.train.152.sent", "type": "sentence", "text": [ "The underlined grey box represents the region involved in the binding of the ADP moiety of FAD." ], "offsets": [ [ 0, 95 ] ] } ]
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[]
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[]
1.0alpha7.train.153
1810603
[ { "id": "1.0alpha7.train.153.sent", "type": "sentence", "text": [ "In a similar study, Schowalter et al. (15) showed that three separate regions of the progesterone receptor HBD could confer hsp90 binding when fused to a mutant PR lacking the HBD." ], "offsets": [ [ 0, 180 ] ] } ]
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[]
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1.0alpha7.train.154
18018466
[ { "id": "1.0alpha7.train.154.sent", "type": "sentence", "text": [ "Chen et al. (2001) recently demonstrated that TNF-alpha induces acetylation of p65 by p300/CBP, thus abrogating the binding of p65 to IkappaBalpha." ], "offsets": [ [ 0, 147 ] ] } ]
[ { "id": "1.0alpha7.train.154.ent0_0", "type": "protein", "text": [ "IkappaBalpha" ], "offsets": [ [ 134, 146 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4792" }, { "db_name": "hgnc", "db_id": "NFKBIA" }, { "db_name": "uniprot", "db_id": "P25963" } ] }, { "id": "1.0alpha7.train.154.ent1_0", "type": "protein", "text": [ "TNF-alpha" ], "offsets": [ [ 46, 55 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7124" }, { "db_name": "hgnc", "db_id": "TNF" }, { "db_name": "uniprot", "db_id": "P01375" } ] }, { "id": "1.0alpha7.train.154.ent2_0", "type": "protein-family", "text": [ "p300/CBP" ], "offsets": [ [ 86, 94 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR038547" } ] }, { "id": "1.0alpha7.train.154.ent3_0", "type": "protein", "text": [ "p65" ], "offsets": [ [ 79, 82 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5970" }, { "db_name": "hgnc", "db_id": "RELA" }, { "db_name": "uniprot", "db_id": "Q04206" } ] }, { "id": "1.0alpha7.train.154.ent4_1", "type": "protein", "text": [ "p65" ], "offsets": [ [ 127, 130 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5970" }, { "db_name": "hgnc", "db_id": "RELA" }, { "db_name": "uniprot", "db_id": "Q04206" } ] } ]
[]
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1.0alpha7.train.155
3232148
[ { "id": "1.0alpha7.train.155.sent", "type": "sentence", "text": [ "A difference in the NAD+/NADH binding properties of dI in its isolated form and in the complete, membrane-bound protein was also inferred from a steady-state kinetic analysis (7). " ], "offsets": [ [ 0, 180 ] ] } ]
[ { "id": "1.0alpha7.train.155.ent0_0", "type": "chemical", "text": [ "NAD+" ], "offsets": [ [ 20, 24 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "925" } ] }, { "id": "1.0alpha7.train.155.ent1_0", "type": "chemical", "text": [ "NADH" ], "offsets": [ [ 25, 29 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "439153" } ] }, { "id": "1.0alpha7.train.155.ent2_0", "type": "protein-domain", "text": [ "dI" ], "offsets": [ [ 52, 54 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.156
9524636
[ { "id": "1.0alpha7.train.156.sent", "type": "sentence", "text": [ "EGF-like rpts, epidermal growth factor-like repeats; L/N rpts, Lin12/Notch repeats; CDC, CDC10/Ankyrin repeats; OPA, Glutamine-rich sequence; Dab, Disabled; Dx, Deltex; Dsh, Dishevelled; H, Hairless (exact binding site is not known)." ], "offsets": [ [ 0, 233 ] ] } ]
[ { "id": "1.0alpha7.train.156.ent0_0", "type": "gene", "text": [ "Disabled" ], "offsets": [ [ 147, 155 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1600" }, { "db_name": "hgnc", "db_id": "DAB1" } ] }, { "id": "1.0alpha7.train.156.ent1_0", "type": "gene", "text": [ "Dab" ], "offsets": [ [ 142, 145 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1600" }, { "db_name": "hgnc", "db_id": "DAB1" } ] }, { "id": "1.0alpha7.train.156.ent2_0", "type": "protein-motif", "text": [ "EGF-like rpts" ], "offsets": [ [ 0, 13 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR013032" } ] }, { "id": "1.0alpha7.train.156.ent3_0", "type": "protein-motif", "text": [ "epidermal growth factor-like repeats" ], "offsets": [ [ 15, 51 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR013032" } ] }, { "id": "1.0alpha7.train.156.ent4_0", "type": "gene", "text": [ "Dishevelled" ], "offsets": [ [ 174, 185 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1855" }, { "db_name": "hgnc", "db_id": "DVL1" } ] }, { "id": "1.0alpha7.train.156.ent5_0", "type": "gene", "text": [ "Dsh" ], "offsets": [ [ 169, 172 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1855" }, { "db_name": "hgnc", "db_id": "DVL1" } ] }, { "id": "1.0alpha7.train.156.ent6_0", "type": "protein-motif", "text": [ "CDC10/Ankyrin repeats" ], "offsets": [ [ 89, 110 ] ], "normalized": [] }, { "id": "1.0alpha7.train.156.ent7_0", "type": "protein-motif", "text": [ "CDC" ], "offsets": [ [ 84, 87 ] ], "normalized": [] }, { "id": "1.0alpha7.train.156.ent8_0", "type": "protein-motif", "text": [ "Lin12/Notch repeats" ], "offsets": [ [ 63, 82 ] ], "normalized": [] }, { "id": "1.0alpha7.train.156.ent9_0", "type": "protein-motif", "text": [ "L/N rpts" ], "offsets": [ [ 53, 61 ] ], "normalized": [] }, { "id": "1.0alpha7.train.156.ent10_0", "type": "gene", "text": [ "H" ], "offsets": [ [ 187, 188 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "55806" }, { "db_name": "hgnc", "db_id": "HR" } ] }, { "id": "1.0alpha7.train.156.ent11_0", "type": "gene", "text": [ "Hairless" ], "offsets": [ [ 190, 198 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "55806" }, { "db_name": "hgnc", "db_id": "HR" } ] }, { "id": "1.0alpha7.train.156.ent12_0", "type": "protein-motif", "text": [ "OPA" ], "offsets": [ [ 112, 115 ] ], "normalized": [] }, { "id": "1.0alpha7.train.156.ent13_0", "type": "protein-motif", "text": [ "Glutamine-rich sequence" ], "offsets": [ [ 117, 140 ] ], "normalized": [] }, { "id": "1.0alpha7.train.156.ent14_0", "type": "gene", "text": [ "Deltex" ], "offsets": [ [ 161, 167 ] ], "normalized": [] }, { "id": "1.0alpha7.train.156.ent15_0", "type": "gene", "text": [ "Dx" ], "offsets": [ [ 157, 159 ] ], "normalized": [] } ]
[]
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[]
1.0alpha7.train.157
883977
[ { "id": "1.0alpha7.train.157.sent", "type": "sentence", "text": [ "Second, it is now believed that p27KIP1 interacts mostly with D-type cyclins and CDK4 and more weakly with cyclin E and CDK2, and that binding of p27KIP1 to cyclin D-CDK4 would allow the activation of cyclin E-CDK2 complexes at the G1-S transition (54, 55, 56)." ], "offsets": [ [ 0, 261 ] ] } ]
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[]
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1.0alpha7.train.158
5052631
[ { "id": "1.0alpha7.train.158.sent", "type": "sentence", "text": [ "DNase I footprinting assays showed that the interaction prevents binding of Sp1 to the GC boxes of the ADH5/ FDH promoter." ], "offsets": [ [ 0, 122 ] ] } ]
[ { "id": "1.0alpha7.train.158.ent0_0", "type": "protein", "text": [ "DNase I" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1773" }, { "db_name": "hgnc", "db_id": "DNASE1" }, { "db_name": "uniprot", "db_id": "P24855" } ] }, { "id": "1.0alpha7.train.158.ent1_0", "type": "gene", "text": [ "FDH" ], "offsets": [ [ 109, 112 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "128" }, { "db_name": "hgnc", "db_id": "ADH5" } ] }, { "id": "1.0alpha7.train.158.ent2_0", "type": "gene", "text": [ "ADH5" ], "offsets": [ [ 103, 107 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "128" }, { "db_name": "hgnc", "db_id": "ADH5" } ] }, { "id": "1.0alpha7.train.158.ent3_0", "type": "DNA", "text": [ "ADH5/ FDH promoter" ], "offsets": [ [ 103, 121 ] ], "normalized": [] }, { "id": "1.0alpha7.train.158.ent4_0", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 76, 79 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.158.ent5_0", "type": "DNA", "text": [ "GC boxes" ], "offsets": [ [ 87, 95 ] ], "normalized": [] } ]
[]
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[ { "id": "1.0alpha7.train.158.rel0s1.0alpha7.train.158.ent3_0.o1.0alpha7.train.158.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.158.ent3_0", "arg2_id": "1.0alpha7.train.158.ent4_0", "normalized": [] } ]
1.0alpha7.train.159
6757035
[ { "id": "1.0alpha7.train.159.sent", "type": "sentence", "text": [ "We suggest that, without p35, Cdk5 is bound and activated by Pho85 cyclins, which then direct Cdk5 to Pho85 substrates, allowing functional complementation of the pho85delta strain." ], "offsets": [ [ 0, 181 ] ] } ]
[ { "id": "1.0alpha7.train.159.ent0_0", "type": "protein", "text": [ "pho85delta" ], "offsets": [ [ 163, 173 ] ], "normalized": [] }, { "id": "1.0alpha7.train.159.ent1_0", "type": "protein", "text": [ "Pho85" ], "offsets": [ [ 61, 66 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P17157" } ] }, { "id": "1.0alpha7.train.159.ent2_1", "type": "protein", "text": [ "Pho85" ], "offsets": [ [ 102, 107 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P17157" } ] }, { "id": "1.0alpha7.train.159.ent3_0", "type": "protein-family", "text": [ "Pho85 cyclins" ], "offsets": [ [ 61, 74 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR012104" } ] }, { "id": "1.0alpha7.train.159.ent4_0", "type": "protein", "text": [ "Cdk5" ], "offsets": [ [ 30, 34 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1020" }, { "db_name": "hgnc", "db_id": "CDK5" }, { "db_name": "uniprot", "db_id": "Q00535" } ] }, { "id": "1.0alpha7.train.159.ent5_1", "type": "protein", "text": [ "Cdk5" ], "offsets": [ [ 94, 98 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1020" }, { "db_name": "hgnc", "db_id": "CDK5" }, { "db_name": "uniprot", "db_id": "Q00535" } ] }, { "id": "1.0alpha7.train.159.ent6_0", "type": "protein", "text": [ "p35" ], "offsets": [ [ 25, 28 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8851" }, { "db_name": "hgnc", "db_id": "CDK5R1" }, { "db_name": "uniprot", "db_id": "Q15078" } ] } ]
[]
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[ { "id": "1.0alpha7.train.159.rel0s1.0alpha7.train.159.ent3_0.o1.0alpha7.train.159.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.159.ent3_0", "arg2_id": "1.0alpha7.train.159.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.159.rel0s1.0alpha7.train.159.ent3_0.o1.0alpha7.train.159.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.159.ent3_0", "arg2_id": "1.0alpha7.train.159.ent5_1", "normalized": [] } ]
1.0alpha7.train.160
21938299
[ { "id": "1.0alpha7.train.160.sent", "type": "sentence", "text": [ "On the other hand, 13 genes (Alpha-tubulin, Swiprosin-2, Insulin-like growth factor binding protein 2 [IGFBP2], CRBP, Apo D, NU, Claudin-3, Uncoupling protein-2 [UCP-2], CRIP-1, MT 1G, Apolipoprotein CI [Apo CI], CLF-1, Transglutaminase-2) retained high cytosine content in their CpG islands or CpG sites deemed critical for transcription (Apo D) after bisulfite treatment, indicating heavy cytosine methylation (Figures 3A and 3B)." ], "offsets": [ [ 0, 432 ] ] } ]
[ { "id": "1.0alpha7.train.160.ent0_0", "type": "gene", "text": [ "Apo CI" ], "offsets": [ [ 204, 210 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "341" }, { "db_name": "hgnc", "db_id": "APOC1" } ] }, { "id": "1.0alpha7.train.160.ent1_0", "type": "gene", "text": [ "Claudin-3" ], "offsets": [ [ 129, 138 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1365" }, { "db_name": "hgnc", "db_id": "CLDN3" } ] }, { "id": "1.0alpha7.train.160.ent2_0", "type": "gene", "text": [ "Apo D" ], "offsets": [ [ 118, 123 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "347" }, { "db_name": "hgnc", "db_id": "APOD" } ] }, { "id": "1.0alpha7.train.160.ent3_1", "type": "gene", "text": [ "Apo D" ], "offsets": [ [ 340, 345 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "347" }, { "db_name": "hgnc", "db_id": "APOD" } ] }, { "id": "1.0alpha7.train.160.ent4_0", "type": "gene", "text": [ "Swiprosin-2" ], "offsets": [ [ 44, 55 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "80303" }, { "db_name": "hgnc", "db_id": "EFHD1" }, { "db_name": "uniprot", "db_id": "Q9BUP0" } ] }, { "id": "1.0alpha7.train.160.ent5_0", "type": "gene", "text": [ "MT 1G" ], "offsets": [ [ 178, 183 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4495" }, { "db_name": "hgnc", "db_id": "MT1G" } ] }, { "id": "1.0alpha7.train.160.ent6_0", "type": "gene", "text": [ "Uncoupling protein-2" ], "offsets": [ [ 140, 160 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7351" }, { "db_name": "hgnc", "db_id": "UCP2" } ] }, { "id": "1.0alpha7.train.160.ent7_0", "type": "gene", "text": [ "UCP-2" ], "offsets": [ [ 162, 167 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7351" }, { "db_name": "hgnc", "db_id": "UCP2" } ] }, { "id": "1.0alpha7.train.160.ent8_0", "type": "gene", "text": [ "CRBP" ], "offsets": [ [ 112, 116 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5947" }, { "db_name": "hgnc", "db_id": "CRBP" } ] }, { "id": "1.0alpha7.train.160.ent9_0", "type": "gene", "text": [ "Apolipoprotein CI" ], "offsets": [ [ 185, 202 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "341" }, { "db_name": "hgnc", "db_id": "APOC1" } ] }, { "id": "1.0alpha7.train.160.ent10_0", "type": "DNA", "text": [ "CpG sites" ], "offsets": [ [ 295, 304 ] ], "normalized": [] }, { "id": "1.0alpha7.train.160.ent11_0", "type": "gene", "text": [ "IGFBP2" ], "offsets": [ [ 103, 109 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3485" }, { "db_name": "hgnc", "db_id": "IGFBP2" }, { "db_name": "uniprot", "db_id": "P18065" } ] }, { "id": "1.0alpha7.train.160.ent12_0", "type": "gene", "text": [ "Insulin-like growth factor binding protein 2" ], "offsets": [ [ 57, 101 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3485" }, { "db_name": "hgnc", "db_id": "IGFBP2" }, { "db_name": "uniprot", "db_id": "P18065" } ] }, { "id": "1.0alpha7.train.160.ent13_0", "type": "gene", "text": [ "CLF-1" ], "offsets": [ [ 213, 218 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "9244" }, { "db_name": "hgnc", "db_id": "CLF1" } ] }, { "id": "1.0alpha7.train.160.ent14_0", "type": "DNA", "text": [ "CpG islands" ], "offsets": [ [ 280, 291 ] ], "normalized": [] }, { "id": "1.0alpha7.train.160.ent15_0", "type": "gene", "text": [ "CRIP-1" ], "offsets": [ [ 170, 176 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25927" }, { "db_name": "hgnc", "db_id": "CNRIP1" } ] }, { "id": "1.0alpha7.train.160.ent16_0", "type": "gene", "text": [ "Alpha-tubulin" ], "offsets": [ [ 29, 42 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "10376" }, { "db_name": "hgnc", "db_id": "TUBA1B" }, { "db_name": "uniprot", "db_id": "P68363" } ] }, { "id": "1.0alpha7.train.160.ent17_0", "type": "gene", "text": [ "Transglutaminase-2" ], "offsets": [ [ 220, 238 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7052" }, { "db_name": "hgnc", "db_id": "TGM2" } ] }, { "id": "1.0alpha7.train.160.ent18_0", "type": "gene", "text": [ "NU" ], "offsets": [ [ 125, 127 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "353497" }, { "db_name": "hgnc", "db_id": "POLN" } ] } ]
[]
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[]
1.0alpha7.train.161
9202451
[ { "id": "1.0alpha7.train.161.sent", "type": "sentence", "text": [ "The EGFR is activated by several ligands such as epidermal growth factor (EGF), transforming growth factor (TGF ), amphiregulin, heparin binding EGF (HB-EGF), beta-cellulin, and epiregulin (Prigent and Lemoine, 1992 ; Earp et al., 1995 )." ], "offsets": [ [ 0, 238 ] ] } ]
[ { "id": "1.0alpha7.train.161.ent0_0", "type": "protein", "text": [ "amphiregulin" ], "offsets": [ [ 115, 127 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "374" }, { "db_name": "hgnc", "db_id": "AREG" }, { "db_name": "uniprot", "db_id": "P15514" } ] }, { "id": "1.0alpha7.train.161.ent1_0", "type": "protein-family", "text": [ "TGF" ], "offsets": [ [ 108, 111 ] ], "normalized": [] }, { "id": "1.0alpha7.train.161.ent2_0", "type": "protein-family", "text": [ "transforming growth factor" ], "offsets": [ [ 80, 106 ] ], "normalized": [] }, { "id": "1.0alpha7.train.161.ent3_0", "type": "protein", "text": [ "beta-cellulin" ], "offsets": [ [ 159, 172 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "685" }, { "db_name": "hgnc", "db_id": "BTC" }, { "db_name": "uniprot", "db_id": "P35070" } ] }, { "id": "1.0alpha7.train.161.ent4_0", "type": "protein", "text": [ "EGFR" ], "offsets": [ [ 4, 8 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1956" }, { "db_name": "hgnc", "db_id": "EGFR" }, { "db_name": "uniprot", "db_id": "P00533" } ] }, { "id": "1.0alpha7.train.161.ent5_0", "type": "protein", "text": [ "HB-EGF" ], "offsets": [ [ 150, 156 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1839" }, { "db_name": "hgnc", "db_id": "HBEGF" }, { "db_name": "uniprot", "db_id": "Q99075" } ] }, { "id": "1.0alpha7.train.161.ent6_0", "type": "protein", "text": [ "heparin binding EGF" ], "offsets": [ [ 129, 148 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1839" }, { "db_name": "hgnc", "db_id": "HBEGF" }, { "db_name": "uniprot", "db_id": "Q99075" } ] }, { "id": "1.0alpha7.train.161.ent7_0", "type": "protein", "text": [ "epiregulin" ], "offsets": [ [ 178, 188 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2069" }, { "db_name": "hgnc", "db_id": "EREG" }, { "db_name": "uniprot", "db_id": "O14944" } ] }, { "id": "1.0alpha7.train.161.ent8_0", "type": "protein", "text": [ "epidermal growth factor" ], "offsets": [ [ 49, 72 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1950" }, { "db_name": "hgnc", "db_id": "EGF" }, { "db_name": "uniprot", "db_id": "P01133" } ] }, { "id": "1.0alpha7.train.161.ent9_0", "type": "protein", "text": [ "EGF" ], "offsets": [ [ 74, 77 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1950" }, { "db_name": "hgnc", "db_id": "EGF" }, { "db_name": "uniprot", "db_id": "P01133" } ] }, { "id": "1.0alpha7.train.161.ent10_1", "type": "protein", "text": [ "EGF" ], "offsets": [ [ 145, 148 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1950" }, { "db_name": "hgnc", "db_id": "EGF" }, { "db_name": "uniprot", "db_id": "P01133" } ] }, { "id": "1.0alpha7.train.161.ent11_2", "type": "protein", "text": [ "EGF" ], "offsets": [ [ 153, 156 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1950" }, { "db_name": "hgnc", "db_id": "EGF" }, { "db_name": "uniprot", "db_id": "P01133" } ] } ]
[]
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1.0alpha7.train.162
25368349
[ { "id": "1.0alpha7.train.162.sent", "type": "sentence", "text": [ "Genetic mutants lacking adenylyl cyclase, cAMP-dependent protein kinase (PKA), or cAMP response element ( CRE) binding protein (CREB) exhibit significant defects in different forms of behavioral learning and memory (Livingston et al., 1984 ; Foster et al." ], "offsets": [ [ 0, 255 ] ] } ]
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[]
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1.0alpha7.train.163
15178699
[ { "id": "1.0alpha7.train.163.sent", "type": "sentence", "text": [ "Apart from nonimmune controls, we studied the c-jun promoter and found no binding of p300 and SAF-A to this site." ], "offsets": [ [ 0, 113 ] ] } ]
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[]
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1.0alpha7.train.164
5429201
[ { "id": "1.0alpha7.train.164.sent", "type": "sentence", "text": [ "However, both assays revealed that double mutation of these residues to alanine abrogated binding of mSTI1 to Hsc70." ], "offsets": [ [ 0, 116 ] ] } ]
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[]
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1.0alpha7.train.165
6201453
[ { "id": "1.0alpha7.train.165.sent", "type": "sentence", "text": [ "As a result, E2F6 lacks the sequences that mediate the transcriptional activation or pRB, p107, and p130 binding properties of the other E2F proteins." ], "offsets": [ [ 0, 150 ] ] } ]
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[]
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[]
1.0alpha7.train.166
16569943
[ { "id": "1.0alpha7.train.166.sent", "type": "sentence", "text": [ "The TNF-alpha and IL-1beta protein synthesis were followed to further study the consequences of the decreased LPS-induced binding of NF-kappaB and AP-1 to the TNF-alpha and IL-1beta promotors." ], "offsets": [ [ 0, 192 ] ] } ]
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[]
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1.0alpha7.train.167
12533848
[ { "id": "1.0alpha7.train.167.sent", "type": "sentence", "text": [ "Binding of the 4E-BPs to eIF4E is regulated by phosphorylation ( Lin et al. 1994 ; Pause et al. 1994 )." ], "offsets": [ [ 0, 103 ] ] } ]
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[]
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1.0alpha7.train.168
13041757
[ { "id": "1.0alpha7.train.168.sent", "type": "sentence", "text": [ "Binding of trithorax and Polycomb proteins to the bithorax complex: dynamic changes during early Drosophila embryogenesis." ], "offsets": [ [ 0, 122 ] ] } ]
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[]
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1.0alpha7.train.169
3796587
[ { "id": "1.0alpha7.train.169.sent", "type": "sentence", "text": [ "In support of this hypothesis, PU.1 binding to the μB site is undetectable in EMSA analyses of B cell nuclear extracts despite the demonstrations that 1) DNA-binding PU.1 is present in B cell nuclei and 2) recombinant PU.1 binds the μB site in a variety of analyses (3, 25, 41)." ], "offsets": [ [ 0, 278 ] ] } ]
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[]
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1.0alpha7.train.170
19694236
[ { "id": "1.0alpha7.train.170.sent", "type": "sentence", "text": [ "Pho and Phol bind to the same DNA sequence phol is located on chromosome 3 in polytene subdivision 67B and is designated by the Drosophila genome project as CG3445." ], "offsets": [ [ 0, 164 ] ] } ]
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[]
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1.0alpha7.train.171
11817587
[ { "id": "1.0alpha7.train.171.sent", "type": "sentence", "text": [ "The Tir-binding fragment of intimin (i.e. Int190, D3 and D4) is illustrated by the space filling representation shown in (B)." ], "offsets": [ [ 0, 125 ] ] } ]
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[]
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