Datasets:

knowledgator

/

bio-NER-relations

like 2

Follow

Knowledgator Engineering 51

[ { "id": "BioInfer.d675.s0__text", "type": "Sentence", "text": [ "The proteins encoded by MRS5 and MRS11, which display 35%, sequence identity are both located in the mitochondrial intermembrane space." ], "offsets": [ [ 0, 135 ] ] } ]

[ { "id": "BioInfer.d675.s0.e0", "type": "Gene", "text": [ "MRS5" ], "offsets": [ [ 24, 28 ] ], "normalized": [] }, { "id": "BioInfer.d675.s0.e1", "type": "Gene", "text": [ "MRS11" ], "offsets": [ [ 33, 38 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d675.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d675.s0.e0", "arg2_id": "BioInfer.d675.s0.e1", "normalized": [] } ]

[ { "id": "BioInfer.d676.s0__text", "type": "Sentence", "text": [ "The proximity of the semi-conserved actin-binding site and the binding pocket characteristic of plant profilins suggests that epitopes encompassing both features are responsible for the cross-reactivity of antibodies between human and plant profilins thought to be responsible for type I allergies." ], "offsets": [ [ 0, 298 ] ] } ]

[ { "id": "BioInfer.d676.s0.e0", "type": "Gene/protein/RNA", "text": [ "actin" ], "offsets": [ [ 36, 41 ] ], "normalized": [] }, { "id": "BioInfer.d676.s0.e1", "type": "Gene/protein/RNA", "text": [ "profilins" ], "offsets": [ [ 102, 111 ] ], "normalized": [] }, { "id": "BioInfer.d676.s0.e2", "type": "Individual_protein", "text": [ "profilins" ], "offsets": [ [ 241, 250 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d678.s0__text", "type": "Sentence", "text": [ "The radioresistant N10 and parental KB cell lines were examined for the expression of human DNA repair genes which were related to the repair of radiation-induced DNA damage by northern blot analysis using five kinds of DNA probes (XRCC1, XRCC3, XRCC5, RAD51, RAD52)." ], "offsets": [ [ 0, 267 ] ] } ]

[ { "id": "BioInfer.d678.s0.e0", "type": "Gene/protein/RNA", "text": [ "XRCC5" ], "offsets": [ [ 246, 251 ] ], "normalized": [] }, { "id": "BioInfer.d678.s0.e1", "type": "Gene/protein/RNA", "text": [ "XRCC1" ], "offsets": [ [ 232, 237 ] ], "normalized": [] }, { "id": "BioInfer.d678.s0.e2", "type": "Gene/protein/RNA", "text": [ "RAD52" ], "offsets": [ [ 260, 265 ] ], "normalized": [] }, { "id": "BioInfer.d678.s0.e3", "type": "Gene/protein/RNA", "text": [ "XRCC3" ], "offsets": [ [ 239, 244 ] ], "normalized": [] }, { "id": "BioInfer.d678.s0.e4", "type": "Gene/protein/RNA", "text": [ "RAD51" ], "offsets": [ [ 253, 258 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d680.s0__text", "type": "Sentence", "text": [ "There are only 14 non-conservative substitutions in the two myosin heavy chains, three of which are located in the secondary actin-binding loop and flanking regions and others correspond to residues so far not assigned a functional role, including two residues in the proximal S2 domain." ], "offsets": [ [ 0, 287 ] ] } ]

[ { "id": "BioInfer.d680.s0.e0", "type": "Individual_protein", "text": [ "myosin heavy chains" ], "offsets": [ [ 60, 79 ] ], "normalized": [] }, { "id": "BioInfer.d680.s0.e1", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 125, 130 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d680.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d680.s0.e0", "arg2_id": "BioInfer.d680.s0.e1", "normalized": [] } ]

[ { "id": "BioInfer.d682.s0__text", "type": "Sentence", "text": [ "The recombinant material is similar to authentic profilin from Acanthamoeba-based on fluorescence monitored urea denaturation, circular dichroism, actin-nucleotide exchange rate and the Kd for rabbit skeletal actin." ], "offsets": [ [ 0, 215 ] ] } ]

[ { "id": "BioInfer.d682.s0.e0", "type": "Individual_protein", "text": [ "skeletal actin" ], "offsets": [ [ 200, 214 ] ], "normalized": [] }, { "id": "BioInfer.d682.s0.e1", "type": "Gene/protein/RNA", "text": [ "actin" ], "offsets": [ [ 147, 152 ] ], "normalized": [] }, { "id": "BioInfer.d682.s0.e2", "type": "Individual_protein", "text": [ "profilin" ], "offsets": [ [ 49, 57 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d682.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d682.s0.e0", "arg2_id": "BioInfer.d682.s0.e2", "normalized": [] } ]

[ { "id": "BioInfer.d683.s0__text", "type": "Sentence", "text": [ "The recombinant material is similar to authentic human platelet profilin based on the measured Kd for rabbit skeletal muscle actin." ], "offsets": [ [ 0, 131 ] ] } ]

[ { "id": "BioInfer.d683.s0.e0", "type": "Individual_protein", "text": [ "skeletal muscle actin" ], "offsets": [ [ 109, 130 ] ], "normalized": [] }, { "id": "BioInfer.d683.s0.e1", "type": "Individual_protein", "text": [ "platelet profilin" ], "offsets": [ [ 55, 72 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d683.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d683.s0.e0", "arg2_id": "BioInfer.d683.s0.e1", "normalized": [] } ]

[ { "id": "BioInfer.d685.s0__text", "type": "Sentence", "text": [ "The resulting beta-catenin product is unable to bind alpha-catenin that is responsible for actin filament binding and organization." ], "offsets": [ [ 0, 131 ] ] } ]

[ { "id": "BioInfer.d685.s0.e0", "type": "Individual_protein", "text": [ "beta-catenin" ], "offsets": [ [ 14, 26 ] ], "normalized": [] }, { "id": "BioInfer.d685.s0.e1", "type": "Individual_protein", "text": [ "alpha-catenin" ], "offsets": [ [ 53, 66 ] ], "normalized": [] }, { "id": "BioInfer.d685.s0.e2", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 91, 96 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d685.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d685.s0.e0", "arg2_id": "BioInfer.d685.s0.e1", "normalized": [] }, { "id": "BioInfer.d685.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d685.s0.e1", "arg2_id": "BioInfer.d685.s0.e2", "normalized": [] } ]

[ { "id": "BioInfer.d686.s0__text", "type": "Sentence", "text": [ "The results clearly showed that the mutated cofilin possessing KTLKK instead of KKRKK did not translocate into the nuclei in response to heat shock whereas a recombinant cofilin with the unaltered sequence of KKRKK responded to heat shock and formed intranuclear rods together with actin." ], "offsets": [ [ 0, 288 ] ] } ]

[ { "id": "BioInfer.d686.s0.e0", "type": "Individual_protein", "text": [ "cofilin" ], "offsets": [ [ 170, 177 ] ], "normalized": [] }, { "id": "BioInfer.d686.s0.e1", "type": "Gene/protein/RNA", "text": [ "cofilin" ], "offsets": [ [ 44, 51 ] ], "normalized": [] }, { "id": "BioInfer.d686.s0.e2", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 282, 287 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d686.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d686.s0.e0", "arg2_id": "BioInfer.d686.s0.e2", "normalized": [] } ]

[ { "id": "BioInfer.d688.s0__text", "type": "Sentence", "text": [ "The results indicate that (a) plakoglobin and beta-catenin differ in their nuclear translocation and complexing with LEF-1 and vinculin; (b) LEF-1-dependent transactivation is preferentially driven by beta-catenin; and (c) the cytoplasmic partners of beta-catenin, cadherin and alpha-catenin, can sequester it to the cytoplasm and inhibit its transcriptional activity." ], "offsets": [ [ 0, 368 ] ] } ]

[ { "id": "BioInfer.d688.s0.e0", "type": "Individual_protein", "text": [ "LEF-1" ], "offsets": [ [ 141, 146 ] ], "normalized": [] }, { "id": "BioInfer.d688.s0.e1", "type": "Individual_protein", "text": [ "LEF-1" ], "offsets": [ [ 117, 122 ] ], "normalized": [] }, { "id": "BioInfer.d688.s0.e2", "type": "Individual_protein", "text": [ "alpha-catenin" ], "offsets": [ [ 278, 291 ] ], "normalized": [] }, { "id": "BioInfer.d688.s0.e3", "type": "Individual_protein", "text": [ "beta-catenin" ], "offsets": [ [ 251, 263 ] ], "normalized": [] }, { "id": "BioInfer.d688.s0.e4", "type": "Individual_protein", "text": [ "vinculin" ], "offsets": [ [ 127, 135 ] ], "normalized": [] }, { "id": "BioInfer.d688.s0.e5", "type": "Individual_protein", "text": [ "plakoglobin" ], "offsets": [ [ 30, 41 ] ], "normalized": [] }, { "id": "BioInfer.d688.s0.e6", "type": "Individual_protein", "text": [ "cadherin" ], "offsets": [ [ 265, 273 ] ], "normalized": [] }, { "id": "BioInfer.d688.s0.e7", "type": "Individual_protein", "text": [ "beta-catenin" ], "offsets": [ [ 201, 213 ] ], "normalized": [] }, { "id": "BioInfer.d688.s0.e8", "type": "Individual_protein", "text": [ "beta-catenin" ], "offsets": [ [ 46, 58 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d688.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d688.s0.e1", "arg2_id": "BioInfer.d688.s0.e5", "normalized": [] }, { "id": "BioInfer.d688.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d688.s0.e1", "arg2_id": "BioInfer.d688.s0.e8", "normalized": [] }, { "id": "BioInfer.d688.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d688.s0.e2", "arg2_id": "BioInfer.d688.s0.e3", "normalized": [] }, { "id": "BioInfer.d688.s0.i3", "type": "PPI", "arg1_id": "BioInfer.d688.s0.e3", "arg2_id": "BioInfer.d688.s0.e6", "normalized": [] }, { "id": "BioInfer.d688.s0.i4", "type": "PPI", "arg1_id": "BioInfer.d688.s0.e4", "arg2_id": "BioInfer.d688.s0.e5", "normalized": [] }, { "id": "BioInfer.d688.s0.i5", "type": "PPI", "arg1_id": "BioInfer.d688.s0.e4", "arg2_id": "BioInfer.d688.s0.e8", "normalized": [] }, { "id": "BioInfer.d688.s0.i6", "type": "PPI", "arg1_id": "BioInfer.d688.s0.e5", "arg2_id": "BioInfer.d688.s0.e8", "normalized": [] } ]

[ { "id": "BioInfer.d692.s0__text", "type": "Sentence", "text": [ "The Schizosaccharomyces pombe rhp51+, rad22+ and rhp54+ genes are homologous to RAD51, RAD52 and RAD54 respectively, which are indispensable in the recombinational repair of double-strand breaks (DSBs) in Saccharomyces cerevisiae." ], "offsets": [ [ 0, 230 ] ] } ]

[ { "id": "BioInfer.d692.s0.e0", "type": "Gene", "text": [ "rhp54+" ], "offsets": [ [ 49, 55 ] ], "normalized": [] }, { "id": "BioInfer.d692.s0.e1", "type": "Gene", "text": [ "RAD54" ], "offsets": [ [ 97, 102 ] ], "normalized": [] }, { "id": "BioInfer.d692.s0.e2", "type": "Gene", "text": [ "RAD51" ], "offsets": [ [ 80, 85 ] ], "normalized": [] }, { "id": "BioInfer.d692.s0.e3", "type": "Gene", "text": [ "rad22+" ], "offsets": [ [ 38, 44 ] ], "normalized": [] }, { "id": "BioInfer.d692.s0.e4", "type": "Gene", "text": [ "rhp51+" ], "offsets": [ [ 30, 36 ] ], "normalized": [] }, { "id": "BioInfer.d692.s0.e5", "type": "Gene", "text": [ "RAD52" ], "offsets": [ [ 87, 92 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d692.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d692.s0.e0", "arg2_id": "BioInfer.d692.s0.e1", "normalized": [] }, { "id": "BioInfer.d692.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d692.s0.e2", "arg2_id": "BioInfer.d692.s0.e4", "normalized": [] }, { "id": "BioInfer.d692.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d692.s0.e3", "arg2_id": "BioInfer.d692.s0.e5", "normalized": [] } ]

[ { "id": "BioInfer.d693.s0__text", "type": "Sentence", "text": [ "These cells have both alpha-catenin and beta-catenin, display unusual expression of N-cadherin, and have the typical fibroblastic phenotype of transformed cells." ], "offsets": [ [ 0, 161 ] ] } ]

[ { "id": "BioInfer.d693.s0.e0", "type": "Gene/protein/RNA", "text": [ "beta-catenin" ], "offsets": [ [ 40, 52 ] ], "normalized": [] }, { "id": "BioInfer.d693.s0.e1", "type": "Gene/protein/RNA", "text": [ "alpha-catenin" ], "offsets": [ [ 22, 35 ] ], "normalized": [] }, { "id": "BioInfer.d693.s0.e2", "type": "Gene/protein/RNA", "text": [ "N-cadherin" ], "offsets": [ [ 84, 94 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d694.s0__text", "type": "Sentence", "text": [ "These data strongly suggest that the head, neck, and tail domains of all myosin heavy chains, and light chains at least of class II myosins, have coevolved and are likely to be functionally interdependent, consistent with biochemical evidence showing that regulated actin-dependent MgATPase activity of Dictyostelium myosin II requires isoform specific interactions between the heavy chain head and tail and light chains." ], "offsets": [ [ 0, 421 ] ] } ]

[ { "id": "BioInfer.d694.s0.e0", "type": "Protein_family_or_group", "text": [ "class II myosins" ], "offsets": [ [ 123, 139 ] ], "normalized": [] }, { "id": "BioInfer.d694.s0.e1", "type": "Individual_protein", "text": [ "myosin II" ], "offsets": [ [ 317, 326 ] ], "normalized": [] }, { "id": "BioInfer.d694.s0.e2", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 266, 271 ] ], "normalized": [] }, { "id": "BioInfer.d694.s0.e3", "type": "Individual_protein", "text": [ "MgATPase" ], "offsets": [ [ 282, 290 ] ], "normalized": [] }, { "id": "BioInfer.d694.s0.e4", "type": "Protein_family_or_group", "text": [ "myosin heavy chains" ], "offsets": [ [ 73, 92 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d694.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d694.s0.e0", "arg2_id": "BioInfer.d694.s0.e1", "normalized": [] }, { "id": "BioInfer.d694.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d694.s0.e0", "arg2_id": "BioInfer.d694.s0.e4", "normalized": [] }, { "id": "BioInfer.d694.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d694.s0.e1", "arg2_id": "BioInfer.d694.s0.e2", "normalized": [] }, { "id": "BioInfer.d694.s0.i3", "type": "PPI", "arg1_id": "BioInfer.d694.s0.e1", "arg2_id": "BioInfer.d694.s0.e3", "normalized": [] }, { "id": "BioInfer.d694.s0.i4", "type": "PPI", "arg1_id": "BioInfer.d694.s0.e1", "arg2_id": "BioInfer.d694.s0.e4", "normalized": [] } ]

[ { "id": "BioInfer.d695.s0__text", "type": "Sentence", "text": [ "These data suggest that nuclear profilin can mediate a stimulus-response action on the actin cytoskeleton which is somehow linked to a phosphoinositide-signaling cascade." ], "offsets": [ [ 0, 170 ] ] } ]

[ { "id": "BioInfer.d695.s0.e0", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 87, 92 ] ], "normalized": [] }, { "id": "BioInfer.d695.s0.e1", "type": "Individual_protein", "text": [ "profilin" ], "offsets": [ [ 32, 40 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d695.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d695.s0.e0", "arg2_id": "BioInfer.d695.s0.e1", "normalized": [] } ]

[ { "id": "BioInfer.d696.s0__text", "type": "Sentence", "text": [ "These differences in contractile protein profiles between single and cultured cells were collaborated with the observation of cells using immunofluorescence microscope with responsible antibodies to isoforms of myosin heavy chain, actin and tropomyosin." ], "offsets": [ [ 0, 253 ] ] } ]

[ { "id": "BioInfer.d696.s0.e0", "type": "Gene/protein/RNA", "text": [ "tropomyosin" ], "offsets": [ [ 241, 252 ] ], "normalized": [] }, { "id": "BioInfer.d696.s0.e1", "type": "Gene/protein/RNA", "text": [ "myosin heavy chain" ], "offsets": [ [ 211, 229 ] ], "normalized": [] }, { "id": "BioInfer.d696.s0.e2", "type": "Gene/protein/RNA", "text": [ "actin" ], "offsets": [ [ 231, 236 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d697.s0__text", "type": "Sentence", "text": [ "These findings reveal striking differences between S. cerevisiae and vertebrates in the functions of RAD51 and RAD52." ], "offsets": [ [ 0, 117 ] ] } ]

[ { "id": "BioInfer.d697.s0.e0", "type": "Gene/protein/RNA", "text": [ "RAD51" ], "offsets": [ [ 101, 106 ] ], "normalized": [] }, { "id": "BioInfer.d697.s0.e1", "type": "Gene/protein/RNA", "text": [ "RAD52" ], "offsets": [ [ 111, 116 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d699.s0__text", "type": "Sentence", "text": [ "These genes were designated UL5, UL8, UL9, UL42, and UL52 and were predicted to encode proteins with molecular weights of, respectively, 99,000, 80,000, 94,000, 51,000, and 114,000." ], "offsets": [ [ 0, 181 ] ] } ]

[ { "id": "BioInfer.d699.s0.e0", "type": "Gene/protein/RNA", "text": [ "UL5" ], "offsets": [ [ 28, 31 ] ], "normalized": [] }, { "id": "BioInfer.d699.s0.e1", "type": "Gene/protein/RNA", "text": [ "UL9" ], "offsets": [ [ 38, 41 ] ], "normalized": [] }, { "id": "BioInfer.d699.s0.e2", "type": "Gene/protein/RNA", "text": [ "UL8" ], "offsets": [ [ 33, 36 ] ], "normalized": [] }, { "id": "BioInfer.d699.s0.e3", "type": "Gene/protein/RNA", "text": [ "UL52" ], "offsets": [ [ 53, 57 ] ], "normalized": [] }, { "id": "BioInfer.d699.s0.e4", "type": "Gene/protein/RNA", "text": [ "UL42" ], "offsets": [ [ 43, 47 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d700.s0__text", "type": "Sentence", "text": [ "These increases were specific; DNA, total protein, lactic dehydrogenase, profilin, and actin depolymerizing factor levels were unchanged in the overexpressing cells." ], "offsets": [ [ 0, 165 ] ] } ]

[ { "id": "BioInfer.d700.s0.e0", "type": "Gene/protein/RNA", "text": [ "profilin" ], "offsets": [ [ 73, 81 ] ], "normalized": [] }, { "id": "BioInfer.d700.s0.e1", "type": "Gene/protein/RNA", "text": [ "actin depolymerizing factor" ], "offsets": [ [ 87, 114 ] ], "normalized": [] }, { "id": "BioInfer.d700.s0.e2", "type": "Gene/protein/RNA", "text": [ "lactic dehydrogenase" ], "offsets": [ [ 51, 71 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d701.s0__text", "type": "Sentence", "text": [ "These observations demonstrate that cardiac development in man, in contrast to rodent heart, is characterized by an up-regulation of the skeletal actin gene, the expression of which does not change in hypertrophied and failing hearts, and suggest that the actin and myosin heavy chain families are independently regulated in human heart." ], "offsets": [ [ 0, 337 ] ] } ]

[ { "id": "BioInfer.d701.s0.e0", "type": "Gene/protein/RNA", "text": [ "skeletal actin" ], "offsets": [ [ 137, 151 ] ], "normalized": [] }, { "id": "BioInfer.d701.s0.e1", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 256, 261 ] ], "normalized": [] }, { "id": "BioInfer.d701.s0.e2", "type": "Individual_protein", "text": [ "myosin heavy chain" ], "offsets": [ [ 266, 284 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d701.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d701.s0.e1", "arg2_id": "BioInfer.d701.s0.e2", "normalized": [] } ]

[ { "id": "BioInfer.d702.s0__text", "type": "Sentence", "text": [ "These phenotypes are similar to those of the mutant of PFY1, which encodes profilin, an actin-binding protein." ], "offsets": [ [ 0, 110 ] ] } ]

[ { "id": "BioInfer.d702.s0.e0", "type": "Gene", "text": [ "PFY1" ], "offsets": [ [ 55, 59 ] ], "normalized": [] }, { "id": "BioInfer.d702.s0.e1", "type": "Protein_family_or_group", "text": [ "actin-binding protein" ], "offsets": [ [ 88, 109 ] ], "normalized": [] }, { "id": "BioInfer.d702.s0.e2", "type": "Individual_protein", "text": [ "profilin" ], "offsets": [ [ 75, 83 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d702.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d702.s0.e0", "arg2_id": "BioInfer.d702.s0.e2", "normalized": [] }, { "id": "BioInfer.d702.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d702.s0.e1", "arg2_id": "BioInfer.d702.s0.e2", "normalized": [] } ]

[ { "id": "BioInfer.d704.s0__text", "type": "Sentence", "text": [ "These proteins each have a verprolin-homology (V) domain, cofilin-homology (C) domain and an acidic (A) region at the C-terminus, through which they activate the Arp2/3 complex, leading to rapid actin polymerization." ], "offsets": [ [ 0, 216 ] ] } ]

[ { "id": "BioInfer.d704.s0.e0", "type": "Gene/protein/RNA", "text": [ "verprolin" ], "offsets": [ [ 27, 36 ] ], "normalized": [] }, { "id": "BioInfer.d704.s0.e1", "type": "Individual_protein", "text": [ "Arp2" ], "offsets": [ [ 162, 166 ] ], "normalized": [] }, { "id": "BioInfer.d704.s0.e2", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 195, 200 ] ], "normalized": [] }, { "id": "BioInfer.d704.s0.e3", "type": "Gene/protein/RNA", "text": [ "cofilin" ], "offsets": [ [ 58, 65 ] ], "normalized": [] }, { "id": "BioInfer.d704.s0.e4", "type": "Individual_protein", "text": [ "Arp", "3" ], "offsets": [ [ 162, 165 ], [ 167, 168 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d704.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d704.s0.e1", "arg2_id": "BioInfer.d704.s0.e2", "normalized": [] }, { "id": "BioInfer.d704.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d704.s0.e1", "arg2_id": "BioInfer.d704.s0.e4", "normalized": [] }, { "id": "BioInfer.d704.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d704.s0.e2", "arg2_id": "BioInfer.d704.s0.e4", "normalized": [] } ]

[ { "id": "BioInfer.d705.s0__text", "type": "Sentence", "text": [ "The sequence of the inhibitory region is similar to that of a beta-hairpin region of the actin-binding protein profilin." ], "offsets": [ [ 0, 120 ] ] } ]

[ { "id": "BioInfer.d705.s0.e0", "type": "Protein_family_or_group", "text": [ "actin-binding protein" ], "offsets": [ [ 89, 110 ] ], "normalized": [] }, { "id": "BioInfer.d705.s0.e1", "type": "Individual_protein", "text": [ "profilin" ], "offsets": [ [ 111, 119 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d705.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d705.s0.e0", "arg2_id": "BioInfer.d705.s0.e1", "normalized": [] } ]

[ { "id": "BioInfer.d706.s0__text", "type": "Sentence", "text": [ "The sequences of the predicted HMP-1, HMP-2, and HMR-1 proteins are related to the cell adhesion proteins alpha-catenin, beta-catenin/Armadillo, and classical cadherin, respectively." ], "offsets": [ [ 0, 182 ] ] } ]

[ { "id": "BioInfer.d706.s0.e0", "type": "Individual_protein", "text": [ "beta-catenin" ], "offsets": [ [ 121, 133 ] ], "normalized": [] }, { "id": "BioInfer.d706.s0.e1", "type": "Protein_family_or_group", "text": [ "cell adhesion proteins" ], "offsets": [ [ 83, 105 ] ], "normalized": [] }, { "id": "BioInfer.d706.s0.e2", "type": "Individual_protein", "text": [ "alpha-catenin" ], "offsets": [ [ 106, 119 ] ], "normalized": [] }, { "id": "BioInfer.d706.s0.e3", "type": "Individual_protein", "text": [ "classical cadherin" ], "offsets": [ [ 149, 167 ] ], "normalized": [] }, { "id": "BioInfer.d706.s0.e4", "type": "Individual_protein", "text": [ "HMP-2" ], "offsets": [ [ 38, 43 ] ], "normalized": [] }, { "id": "BioInfer.d706.s0.e5", "type": "Individual_protein", "text": [ "HMR-1" ], "offsets": [ [ 49, 54 ] ], "normalized": [] }, { "id": "BioInfer.d706.s0.e6", "type": "Individual_protein", "text": [ "Armadillo" ], "offsets": [ [ 134, 143 ] ], "normalized": [] }, { "id": "BioInfer.d706.s0.e7", "type": "Individual_protein", "text": [ "HMP-1" ], "offsets": [ [ 31, 36 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d706.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d706.s0.e0", "arg2_id": "BioInfer.d706.s0.e1", "normalized": [] }, { "id": "BioInfer.d706.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d706.s0.e0", "arg2_id": "BioInfer.d706.s0.e4", "normalized": [] }, { "id": "BioInfer.d706.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d706.s0.e1", "arg2_id": "BioInfer.d706.s0.e2", "normalized": [] }, { "id": "BioInfer.d706.s0.i3", "type": "PPI", "arg1_id": "BioInfer.d706.s0.e1", "arg2_id": "BioInfer.d706.s0.e3", "normalized": [] }, { "id": "BioInfer.d706.s0.i4", "type": "PPI", "arg1_id": "BioInfer.d706.s0.e1", "arg2_id": "BioInfer.d706.s0.e6", "normalized": [] }, { "id": "BioInfer.d706.s0.i5", "type": "PPI", "arg1_id": "BioInfer.d706.s0.e2", "arg2_id": "BioInfer.d706.s0.e7", "normalized": [] }, { "id": "BioInfer.d706.s0.i6", "type": "PPI", "arg1_id": "BioInfer.d706.s0.e3", "arg2_id": "BioInfer.d706.s0.e5", "normalized": [] }, { "id": "BioInfer.d706.s0.i7", "type": "PPI", "arg1_id": "BioInfer.d706.s0.e4", "arg2_id": "BioInfer.d706.s0.e6", "normalized": [] } ]

[ { "id": "BioInfer.d707.s0__text", "type": "Sentence", "text": [ "These regions also interact with the physiologically relevant ligands of profilin, actin and proline-rich peptides." ], "offsets": [ [ 0, 115 ] ] } ]

[ { "id": "BioInfer.d707.s0.e0", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 83, 88 ] ], "normalized": [] }, { "id": "BioInfer.d707.s0.e1", "type": "Individual_protein", "text": [ "profilin" ], "offsets": [ [ 73, 81 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d707.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d707.s0.e0", "arg2_id": "BioInfer.d707.s0.e1", "normalized": [] } ]

[ { "id": "BioInfer.d709.s0__text", "type": "Sentence", "text": [ "These results indicate that phosphorylation of LIM-kinase by ROCK and consequently increased phosphorylation of cofilin by LIM-kinase contribute to Rho-induced reorganization of the actin cytoskeleton." ], "offsets": [ [ 0, 201 ] ] } ]

[ { "id": "BioInfer.d709.s0.e0", "type": "Individual_protein", "text": [ "LIM-kinase" ], "offsets": [ [ 47, 57 ] ], "normalized": [] }, { "id": "BioInfer.d709.s0.e1", "type": "Individual_protein", "text": [ "LIM-kinase" ], "offsets": [ [ 123, 133 ] ], "normalized": [] }, { "id": "BioInfer.d709.s0.e2", "type": "Individual_protein", "text": [ "cofilin" ], "offsets": [ [ 112, 119 ] ], "normalized": [] }, { "id": "BioInfer.d709.s0.e3", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 182, 187 ] ], "normalized": [] }, { "id": "BioInfer.d709.s0.e4", "type": "Individual_protein", "text": [ "Rho" ], "offsets": [ [ 148, 151 ] ], "normalized": [] }, { "id": "BioInfer.d709.s0.e5", "type": "Individual_protein", "text": [ "ROCK" ], "offsets": [ [ 61, 65 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d709.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d709.s0.e0", "arg2_id": "BioInfer.d709.s0.e2", "normalized": [] }, { "id": "BioInfer.d709.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d709.s0.e0", "arg2_id": "BioInfer.d709.s0.e3", "normalized": [] }, { "id": "BioInfer.d709.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d709.s0.e0", "arg2_id": "BioInfer.d709.s0.e5", "normalized": [] }, { "id": "BioInfer.d709.s0.i3", "type": "PPI", "arg1_id": "BioInfer.d709.s0.e1", "arg2_id": "BioInfer.d709.s0.e2", "normalized": [] }, { "id": "BioInfer.d709.s0.i4", "type": "PPI", "arg1_id": "BioInfer.d709.s0.e1", "arg2_id": "BioInfer.d709.s0.e3", "normalized": [] }, { "id": "BioInfer.d709.s0.i5", "type": "PPI", "arg1_id": "BioInfer.d709.s0.e2", "arg2_id": "BioInfer.d709.s0.e3", "normalized": [] }, { "id": "BioInfer.d709.s0.i6", "type": "PPI", "arg1_id": "BioInfer.d709.s0.e2", "arg2_id": "BioInfer.d709.s0.e5", "normalized": [] }, { "id": "BioInfer.d709.s0.i7", "type": "PPI", "arg1_id": "BioInfer.d709.s0.e3", "arg2_id": "BioInfer.d709.s0.e4", "normalized": [] }, { "id": "BioInfer.d709.s0.i8", "type": "PPI", "arg1_id": "BioInfer.d709.s0.e3", "arg2_id": "BioInfer.d709.s0.e5", "normalized": [] } ]

[ { "id": "BioInfer.d710.s0__text", "type": "Sentence", "text": [ "These results show that cofilin/ADF is an important regulator of actin-based cell motility during Drosophila development." ], "offsets": [ [ 0, 121 ] ] } ]

[ { "id": "BioInfer.d710.s0.e0", "type": "Individual_protein", "text": [ "cofilin" ], "offsets": [ [ 24, 31 ] ], "normalized": [] }, { "id": "BioInfer.d710.s0.e1", "type": "Individual_protein", "text": [ "ADF" ], "offsets": [ [ 32, 35 ] ], "normalized": [] }, { "id": "BioInfer.d710.s0.e2", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 65, 70 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d710.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d710.s0.e0", "arg2_id": "BioInfer.d710.s0.e2", "normalized": [] }, { "id": "BioInfer.d710.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d710.s0.e1", "arg2_id": "BioInfer.d710.s0.e2", "normalized": [] } ]

[ { "id": "BioInfer.d711.s0__text", "type": "Sentence", "text": [ "These results suggest that activation of PKC precedes the activation of PI and PIP kinases and that under certain circumstances activation of the kinases and the increased synthesis of PIP and PIP2 may be involved in the polymerization of actin in RBL cells, possibly through the interaction of the polyphosphoinositides with actin-binding proteins such as gelsolin and profilin." ], "offsets": [ [ 0, 379 ] ] } ]

[ { "id": "BioInfer.d711.s0.e0", "type": "Individual_protein", "text": [ "profilin" ], "offsets": [ [ 370, 378 ] ], "normalized": [] }, { "id": "BioInfer.d711.s0.e1", "type": "Protein_family_or_group", "text": [ "actin-binding proteins" ], "offsets": [ [ 326, 348 ] ], "normalized": [] }, { "id": "BioInfer.d711.s0.e2", "type": "Individual_protein", "text": [ "PI", "kinases" ], "offsets": [ [ 72, 74 ], [ 83, 90 ] ], "normalized": [] }, { "id": "BioInfer.d711.s0.e3", "type": "Individual_protein", "text": [ "PKC" ], "offsets": [ [ 41, 44 ] ], "normalized": [] }, { "id": "BioInfer.d711.s0.e4", "type": "Individual_protein", "text": [ "PIP kinases" ], "offsets": [ [ 79, 90 ] ], "normalized": [] }, { "id": "BioInfer.d711.s0.e5", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 239, 244 ] ], "normalized": [] }, { "id": "BioInfer.d711.s0.e6", "type": "Individual_protein", "text": [ "gelsolin" ], "offsets": [ [ 357, 365 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d711.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d711.s0.e0", "arg2_id": "BioInfer.d711.s0.e1", "normalized": [] }, { "id": "BioInfer.d711.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d711.s0.e1", "arg2_id": "BioInfer.d711.s0.e2", "normalized": [] }, { "id": "BioInfer.d711.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d711.s0.e1", "arg2_id": "BioInfer.d711.s0.e3", "normalized": [] }, { "id": "BioInfer.d711.s0.i3", "type": "PPI", "arg1_id": "BioInfer.d711.s0.e1", "arg2_id": "BioInfer.d711.s0.e4", "normalized": [] }, { "id": "BioInfer.d711.s0.i4", "type": "PPI", "arg1_id": "BioInfer.d711.s0.e1", "arg2_id": "BioInfer.d711.s0.e5", "normalized": [] }, { "id": "BioInfer.d711.s0.i5", "type": "PPI", "arg1_id": "BioInfer.d711.s0.e1", "arg2_id": "BioInfer.d711.s0.e6", "normalized": [] }, { "id": "BioInfer.d711.s0.i6", "type": "PPI", "arg1_id": "BioInfer.d711.s0.e2", "arg2_id": "BioInfer.d711.s0.e3", "normalized": [] }, { "id": "BioInfer.d711.s0.i7", "type": "PPI", "arg1_id": "BioInfer.d711.s0.e2", "arg2_id": "BioInfer.d711.s0.e5", "normalized": [] }, { "id": "BioInfer.d711.s0.i8", "type": "PPI", "arg1_id": "BioInfer.d711.s0.e3", "arg2_id": "BioInfer.d711.s0.e4", "normalized": [] }, { "id": "BioInfer.d711.s0.i9", "type": "PPI", "arg1_id": "BioInfer.d711.s0.e3", "arg2_id": "BioInfer.d711.s0.e5", "normalized": [] }, { "id": "BioInfer.d711.s0.i10", "type": "PPI", "arg1_id": "BioInfer.d711.s0.e4", "arg2_id": "BioInfer.d711.s0.e5", "normalized": [] } ]

[ { "id": "BioInfer.d712.s0__text", "type": "Sentence", "text": [ "These results suggest that profilin may be involved in the pathogenesis of glomerulonephritis by reorganizing actin cytoskeleton." ], "offsets": [ [ 0, 129 ] ] } ]

[ { "id": "BioInfer.d712.s0.e0", "type": "Individual_protein", "text": [ "profilin" ], "offsets": [ [ 27, 35 ] ], "normalized": [] }, { "id": "BioInfer.d712.s0.e1", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 110, 115 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d712.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d712.s0.e0", "arg2_id": "BioInfer.d712.s0.e1", "normalized": [] } ]

[ { "id": "BioInfer.d713.s0__text", "type": "Sentence", "text": [ "These results suggest that LIMK2 functions downstream of the Rho-ROCK signalling pathway and plays a role in reorganization of actin filaments and membrane structures, by phosphorylating cofilin/ADF proteins." ], "offsets": [ [ 0, 208 ] ] } ]

[ { "id": "BioInfer.d713.s0.e0", "type": "Individual_protein", "text": [ "ROCK" ], "offsets": [ [ 65, 69 ] ], "normalized": [] }, { "id": "BioInfer.d713.s0.e1", "type": "Individual_protein", "text": [ "LIMK2" ], "offsets": [ [ 27, 32 ] ], "normalized": [] }, { "id": "BioInfer.d713.s0.e2", "type": "Protein_family_or_group", "text": [ "cofilin/ADF" ], "offsets": [ [ 187, 198 ] ], "normalized": [] }, { "id": "BioInfer.d713.s0.e3", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 127, 132 ] ], "normalized": [] }, { "id": "BioInfer.d713.s0.e4", "type": "Individual_protein", "text": [ "Rho" ], "offsets": [ [ 61, 64 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d713.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d713.s0.e0", "arg2_id": "BioInfer.d713.s0.e1", "normalized": [] }, { "id": "BioInfer.d713.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d713.s0.e1", "arg2_id": "BioInfer.d713.s0.e2", "normalized": [] }, { "id": "BioInfer.d713.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d713.s0.e1", "arg2_id": "BioInfer.d713.s0.e3", "normalized": [] }, { "id": "BioInfer.d713.s0.i3", "type": "PPI", "arg1_id": "BioInfer.d713.s0.e1", "arg2_id": "BioInfer.d713.s0.e4", "normalized": [] }, { "id": "BioInfer.d713.s0.i4", "type": "PPI", "arg1_id": "BioInfer.d713.s0.e2", "arg2_id": "BioInfer.d713.s0.e3", "normalized": [] } ]

[ { "id": "BioInfer.d713.s1__text", "type": "Sentence", "text": [ "We report here that LIMK1 and LIMK2 phosphorylate both cofilin and actin-depolymerizing factor (ADF) specifically at Ser-3 and exhibit partially distinct substrate specificity when tested using site-directed cofilin mutants as substrates." ], "offsets": [ [ 0, 238 ] ] } ]

[ { "id": "BioInfer.d713.s1.e0", "type": "Individual_protein", "text": [ "LIMK2" ], "offsets": [ [ 30, 35 ] ], "normalized": [] }, { "id": "BioInfer.d713.s1.e1", "type": "Individual_protein", "text": [ "cofilin" ], "offsets": [ [ 208, 215 ] ], "normalized": [] }, { "id": "BioInfer.d713.s1.e2", "type": "Individual_protein", "text": [ "LIMK1" ], "offsets": [ [ 20, 25 ] ], "normalized": [] }, { "id": "BioInfer.d713.s1.e3", "type": "Individual_protein", "text": [ "ADF" ], "offsets": [ [ 96, 99 ] ], "normalized": [] }, { "id": "BioInfer.d713.s1.e4", "type": "Individual_protein", "text": [ "cofilin" ], "offsets": [ [ 55, 62 ] ], "normalized": [] }, { "id": "BioInfer.d713.s1.e5", "type": "Individual_protein", "text": [ "actin-depolymerizing factor" ], "offsets": [ [ 67, 94 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d713.s1.i0", "type": "PPI", "arg1_id": "BioInfer.d713.s1.e0", "arg2_id": "BioInfer.d713.s1.e1", "normalized": [] }, { "id": "BioInfer.d713.s1.i1", "type": "PPI", "arg1_id": "BioInfer.d713.s1.e0", "arg2_id": "BioInfer.d713.s1.e3", "normalized": [] }, { "id": "BioInfer.d713.s1.i2", "type": "PPI", "arg1_id": "BioInfer.d713.s1.e0", "arg2_id": "BioInfer.d713.s1.e4", "normalized": [] }, { "id": "BioInfer.d713.s1.i3", "type": "PPI", "arg1_id": "BioInfer.d713.s1.e0", "arg2_id": "BioInfer.d713.s1.e5", "normalized": [] }, { "id": "BioInfer.d713.s1.i4", "type": "PPI", "arg1_id": "BioInfer.d713.s1.e1", "arg2_id": "BioInfer.d713.s1.e2", "normalized": [] }, { "id": "BioInfer.d713.s1.i5", "type": "PPI", "arg1_id": "BioInfer.d713.s1.e2", "arg2_id": "BioInfer.d713.s1.e3", "normalized": [] }, { "id": "BioInfer.d713.s1.i6", "type": "PPI", "arg1_id": "BioInfer.d713.s1.e2", "arg2_id": "BioInfer.d713.s1.e4", "normalized": [] }, { "id": "BioInfer.d713.s1.i7", "type": "PPI", "arg1_id": "BioInfer.d713.s1.e2", "arg2_id": "BioInfer.d713.s1.e5", "normalized": [] } ]

[ { "id": "BioInfer.d714.s0__text", "type": "Sentence", "text": [ "These results suggest that the heptapeptide sequence is specific for the interaction with actin and, therefore, may constitute part of the actin-binding domain of cofilin." ], "offsets": [ [ 0, 171 ] ] } ]

[ { "id": "BioInfer.d714.s0.e0", "type": "Gene/protein/RNA", "text": [ "actin" ], "offsets": [ [ 90, 95 ] ], "normalized": [] }, { "id": "BioInfer.d714.s0.e1", "type": "Individual_protein", "text": [ "cofilin" ], "offsets": [ [ 163, 170 ] ], "normalized": [] }, { "id": "BioInfer.d714.s0.e2", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 139, 144 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d714.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d714.s0.e1", "arg2_id": "BioInfer.d714.s0.e2", "normalized": [] } ]

[ { "id": "BioInfer.d715.s0__text", "type": "Sentence", "text": [ "These results suggest that TNF-alpha can cause apoptosis in pancreatic beta cells through TNFR1-linked apoptotic factors, TRADD, FADD, and FLICE, and TNF-induced ceramide production may be involved in the pathways." ], "offsets": [ [ 0, 214 ] ] } ]

[ { "id": "BioInfer.d715.s0.e0", "type": "Individual_protein", "text": [ "TRADD" ], "offsets": [ [ 122, 127 ] ], "normalized": [] }, { "id": "BioInfer.d715.s0.e1", "type": "Individual_protein", "text": [ "TNF-alpha" ], "offsets": [ [ 27, 36 ] ], "normalized": [] }, { "id": "BioInfer.d715.s0.e2", "type": "Individual_protein", "text": [ "FLICE" ], "offsets": [ [ 139, 144 ] ], "normalized": [] }, { "id": "BioInfer.d715.s0.e3", "type": "Individual_protein", "text": [ "FADD" ], "offsets": [ [ 129, 133 ] ], "normalized": [] }, { "id": "BioInfer.d715.s0.e4", "type": "Gene/protein/RNA", "text": [ "TNF" ], "offsets": [ [ 150, 153 ] ], "normalized": [] }, { "id": "BioInfer.d715.s0.e5", "type": "Individual_protein", "text": [ "TNFR1" ], "offsets": [ [ 90, 95 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d715.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d715.s0.e0", "arg2_id": "BioInfer.d715.s0.e1", "normalized": [] }, { "id": "BioInfer.d715.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d715.s0.e0", "arg2_id": "BioInfer.d715.s0.e5", "normalized": [] }, { "id": "BioInfer.d715.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d715.s0.e1", "arg2_id": "BioInfer.d715.s0.e2", "normalized": [] }, { "id": "BioInfer.d715.s0.i3", "type": "PPI", "arg1_id": "BioInfer.d715.s0.e1", "arg2_id": "BioInfer.d715.s0.e3", "normalized": [] }, { "id": "BioInfer.d715.s0.i4", "type": "PPI", "arg1_id": "BioInfer.d715.s0.e2", "arg2_id": "BioInfer.d715.s0.e5", "normalized": [] }, { "id": "BioInfer.d715.s0.i5", "type": "PPI", "arg1_id": "BioInfer.d715.s0.e3", "arg2_id": "BioInfer.d715.s0.e5", "normalized": [] } ]

[ { "id": "BioInfer.d716.s0__text", "type": "Sentence", "text": [ "The serine phosphatases PP1 and PP2A associate with and activate the actin-binding protein cofilin in human T lymphocytes." ], "offsets": [ [ 0, 122 ] ] } ]

[ { "id": "BioInfer.d716.s0.e0", "type": "Protein_family_or_group", "text": [ "actin-binding protein" ], "offsets": [ [ 69, 90 ] ], "normalized": [] }, { "id": "BioInfer.d716.s0.e1", "type": "Individual_protein", "text": [ "cofilin" ], "offsets": [ [ 91, 98 ] ], "normalized": [] }, { "id": "BioInfer.d716.s0.e2", "type": "Individual_protein", "text": [ "PP1" ], "offsets": [ [ 24, 27 ] ], "normalized": [] }, { "id": "BioInfer.d716.s0.e3", "type": "Individual_protein", "text": [ "PP2A" ], "offsets": [ [ 32, 36 ] ], "normalized": [] }, { "id": "BioInfer.d716.s0.e4", "type": "Protein_family_or_group", "text": [ "serine phosphatases" ], "offsets": [ [ 4, 23 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d716.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d716.s0.e0", "arg2_id": "BioInfer.d716.s0.e1", "normalized": [] }, { "id": "BioInfer.d716.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d716.s0.e1", "arg2_id": "BioInfer.d716.s0.e2", "normalized": [] }, { "id": "BioInfer.d716.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d716.s0.e1", "arg2_id": "BioInfer.d716.s0.e3", "normalized": [] }, { "id": "BioInfer.d716.s0.i3", "type": "PPI", "arg1_id": "BioInfer.d716.s0.e2", "arg2_id": "BioInfer.d716.s0.e4", "normalized": [] }, { "id": "BioInfer.d716.s0.i4", "type": "PPI", "arg1_id": "BioInfer.d716.s0.e3", "arg2_id": "BioInfer.d716.s0.e4", "normalized": [] } ]

[ { "id": "BioInfer.d718.s0__text", "type": "Sentence", "text": [ "These two proteins were identified as the phosphorylated and non-phosphorylated forms of the pH-sensitive actin-depolymerizing protein, cofilin, by sequencing of peptide fragments and immunoblotting with a monoclonal antibody specific for cofilin." ], "offsets": [ [ 0, 247 ] ] } ]

[ { "id": "BioInfer.d718.s0.e0", "type": "Gene/protein/RNA", "text": [ "cofilin" ], "offsets": [ [ 239, 246 ] ], "normalized": [] }, { "id": "BioInfer.d718.s0.e1", "type": "Individual_protein", "text": [ "cofilin" ], "offsets": [ [ 136, 143 ] ], "normalized": [] }, { "id": "BioInfer.d718.s0.e2", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 106, 111 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d718.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d718.s0.e1", "arg2_id": "BioInfer.d718.s0.e2", "normalized": [] } ]

[ { "id": "BioInfer.d721.s0__text", "type": "Sentence", "text": [ "The sizes and characteristics of each of the proteins determined from various radiolabelling experiments allowed preliminary identification of the proteins as the large (L; 190 kDa), haemagglutinin neuraminidase (HN; 74 kDa), nucleocapsid (N; 66 kDa), fusion (F0; 63 kDa), phosphoprotein (P; 49 kDa), matrix (M; 43 kDa) and non-structural (V; 35 kDa) proteins." ], "offsets": [ [ 0, 360 ] ] } ]

[ { "id": "BioInfer.d721.s0.e0", "type": "Individual_protein", "text": [ "L" ], "offsets": [ [ 170, 171 ] ], "normalized": [] }, { "id": "BioInfer.d721.s0.e1", "type": "Individual_protein", "text": [ "F0" ], "offsets": [ [ 260, 262 ] ], "normalized": [] }, { "id": "BioInfer.d721.s0.e2", "type": "Individual_protein", "text": [ "fusion", "proteins" ], "offsets": [ [ 252, 258 ], [ 351, 359 ] ], "normalized": [] }, { "id": "BioInfer.d721.s0.e3", "type": "Individual_protein", "text": [ "non-structural", "proteins" ], "offsets": [ [ 324, 338 ], [ 351, 359 ] ], "normalized": [] }, { "id": "BioInfer.d721.s0.e4", "type": "Individual_protein", "text": [ "matrix", "proteins" ], "offsets": [ [ 301, 307 ], [ 351, 359 ] ], "normalized": [] }, { "id": "BioInfer.d721.s0.e5", "type": "Individual_protein", "text": [ "HN" ], "offsets": [ [ 213, 215 ] ], "normalized": [] }, { "id": "BioInfer.d721.s0.e6", "type": "Individual_protein", "text": [ "large", "proteins" ], "offsets": [ [ 163, 168 ], [ 351, 359 ] ], "normalized": [] }, { "id": "BioInfer.d721.s0.e7", "type": "Individual_protein", "text": [ "nucleocapsid", "proteins" ], "offsets": [ [ 226, 238 ], [ 351, 359 ] ], "normalized": [] }, { "id": "BioInfer.d721.s0.e8", "type": "Individual_protein", "text": [ "haemagglutinin neuraminidase", "proteins" ], "offsets": [ [ 183, 211 ], [ 351, 359 ] ], "normalized": [] }, { "id": "BioInfer.d721.s0.e9", "type": "Individual_protein", "text": [ "phosphoprotein", "proteins" ], "offsets": [ [ 273, 287 ], [ 351, 359 ] ], "normalized": [] }, { "id": "BioInfer.d721.s0.e10", "type": "Individual_protein", "text": [ "P" ], "offsets": [ [ 289, 290 ] ], "normalized": [] }, { "id": "BioInfer.d721.s0.e11", "type": "Individual_protein", "text": [ "V" ], "offsets": [ [ 340, 341 ] ], "normalized": [] }, { "id": "BioInfer.d721.s0.e12", "type": "Individual_protein", "text": [ "N" ], "offsets": [ [ 240, 241 ] ], "normalized": [] }, { "id": "BioInfer.d721.s0.e13", "type": "Individual_protein", "text": [ "M" ], "offsets": [ [ 309, 310 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d722.s0__text", "type": "Sentence", "text": [ "The Src homology domain 3 (SH3) of a yeast type I myosin, Myo5p, binds to verprolin and is required for targeting to sites of actin polarization." ], "offsets": [ [ 0, 145 ] ] } ]

[ { "id": "BioInfer.d722.s0.e0", "type": "Individual_protein", "text": [ "verprolin" ], "offsets": [ [ 74, 83 ] ], "normalized": [] }, { "id": "BioInfer.d722.s0.e1", "type": "Individual_protein", "text": [ "Myo5p" ], "offsets": [ [ 58, 63 ] ], "normalized": [] }, { "id": "BioInfer.d722.s0.e2", "type": "Individual_protein", "text": [ "type I myosin" ], "offsets": [ [ 43, 56 ] ], "normalized": [] }, { "id": "BioInfer.d722.s0.e3", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 126, 131 ] ], "normalized": [] }, { "id": "BioInfer.d722.s0.e4", "type": "Individual_protein", "text": [ "Src" ], "offsets": [ [ 4, 7 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d722.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d722.s0.e0", "arg2_id": "BioInfer.d722.s0.e1", "normalized": [] }, { "id": "BioInfer.d722.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d722.s0.e1", "arg2_id": "BioInfer.d722.s0.e2", "normalized": [] }, { "id": "BioInfer.d722.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d722.s0.e1", "arg2_id": "BioInfer.d722.s0.e4", "normalized": [] } ]

[ { "id": "BioInfer.d723.s0__text", "type": "Sentence", "text": [ "The structural homology between cofilin and gelsolin segment-1 binding to actin was confirmed experimentally by two types of competitive binding assays." ], "offsets": [ [ 0, 152 ] ] } ]

[ { "id": "BioInfer.d723.s0.e0", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 74, 79 ] ], "normalized": [] }, { "id": "BioInfer.d723.s0.e1", "type": "Individual_protein", "text": [ "gelsolin" ], "offsets": [ [ 44, 52 ] ], "normalized": [] }, { "id": "BioInfer.d723.s0.e2", "type": "Individual_protein", "text": [ "cofilin" ], "offsets": [ [ 32, 39 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d723.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d723.s0.e0", "arg2_id": "BioInfer.d723.s0.e1", "normalized": [] }, { "id": "BioInfer.d723.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d723.s0.e0", "arg2_id": "BioInfer.d723.s0.e2", "normalized": [] }, { "id": "BioInfer.d723.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d723.s0.e1", "arg2_id": "BioInfer.d723.s0.e2", "normalized": [] } ]

[ { "id": "BioInfer.d724.s0__text", "type": "Sentence", "text": [ "The structure of an actin-crosslinking domain from human fimbrin." ], "offsets": [ [ 0, 65 ] ] } ]

[ { "id": "BioInfer.d724.s0.e0", "type": "Individual_protein", "text": [ "fimbrin" ], "offsets": [ [ 57, 64 ] ], "normalized": [] }, { "id": "BioInfer.d724.s0.e1", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 20, 25 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d724.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d724.s0.e0", "arg2_id": "BioInfer.d724.s0.e1", "normalized": [] } ]

[ { "id": "BioInfer.d725.s0__text", "type": "Sentence", "text": [ "The structure of Ykt6pN differed entirely from that of syntaxin and resembled the overall fold of the actin regulatory protein, profilin." ], "offsets": [ [ 0, 137 ] ] } ]

[ { "id": "BioInfer.d725.s0.e0", "type": "Individual_protein", "text": [ "syntaxin" ], "offsets": [ [ 55, 63 ] ], "normalized": [] }, { "id": "BioInfer.d725.s0.e1", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 102, 107 ] ], "normalized": [] }, { "id": "BioInfer.d725.s0.e2", "type": "Individual_protein", "text": [ "Ykt6pN" ], "offsets": [ [ 17, 23 ] ], "normalized": [] }, { "id": "BioInfer.d725.s0.e3", "type": "Individual_protein", "text": [ "profilin" ], "offsets": [ [ 128, 136 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d725.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d725.s0.e0", "arg2_id": "BioInfer.d725.s0.e2", "normalized": [] }, { "id": "BioInfer.d725.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d725.s0.e1", "arg2_id": "BioInfer.d725.s0.e3", "normalized": [] }, { "id": "BioInfer.d725.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d725.s0.e2", "arg2_id": "BioInfer.d725.s0.e3", "normalized": [] } ]

[ { "id": "BioInfer.d726.s0__text", "type": "Sentence", "text": [ "The Tetrahymena fimbrin has two actin-binding domains, but lacks the EF-hand Ca(2+)-binding motif, suggesting that Tetrahymena fimbrin probably cross-links actin filaments in a Ca(2+)- insensitive manner during cytokinesis." ], "offsets": [ [ 0, 223 ] ] } ]

[ { "id": "BioInfer.d726.s0.e0", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 156, 161 ] ], "normalized": [] }, { "id": "BioInfer.d726.s0.e1", "type": "Individual_protein", "text": [ "fimbrin" ], "offsets": [ [ 16, 23 ] ], "normalized": [] }, { "id": "BioInfer.d726.s0.e2", "type": "Individual_protein", "text": [ "fimbrin" ], "offsets": [ [ 127, 134 ] ], "normalized": [] }, { "id": "BioInfer.d726.s0.e3", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 32, 37 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d726.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d726.s0.e0", "arg2_id": "BioInfer.d726.s0.e2", "normalized": [] }, { "id": "BioInfer.d726.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d726.s0.e1", "arg2_id": "BioInfer.d726.s0.e3", "normalized": [] } ]

[ { "id": "BioInfer.d727.s0__text", "type": "Sentence", "text": [ "The tumor necrosis factor receptor 1 (TNFR1) and the Fas receptor recruit complexes formed by the interactions between RIP kinase, TRADD, FADD and RAIDD - adaptor proteins that contain death domains - which in turn recruit other proteins to initiate signaling [1][2][3][4][5]." ], "offsets": [ [ 0, 276 ] ] } ]

[ { "id": "BioInfer.d727.s0.e0", "type": "Individual_protein", "text": [ "TRADD" ], "offsets": [ [ 131, 136 ] ], "normalized": [] }, { "id": "BioInfer.d727.s0.e1", "type": "Individual_protein", "text": [ "RAIDD" ], "offsets": [ [ 147, 152 ] ], "normalized": [] }, { "id": "BioInfer.d727.s0.e2", "type": "Individual_protein", "text": [ "TNFR1" ], "offsets": [ [ 38, 43 ] ], "normalized": [] }, { "id": "BioInfer.d727.s0.e3", "type": "Individual_protein", "text": [ "Fas" ], "offsets": [ [ 53, 56 ] ], "normalized": [] }, { "id": "BioInfer.d727.s0.e4", "type": "Individual_protein", "text": [ "tumor necrosis factor receptor 1" ], "offsets": [ [ 4, 36 ] ], "normalized": [] }, { "id": "BioInfer.d727.s0.e5", "type": "Individual_protein", "text": [ "RIP kinase" ], "offsets": [ [ 119, 129 ] ], "normalized": [] }, { "id": "BioInfer.d727.s0.e6", "type": "Individual_protein", "text": [ "FADD" ], "offsets": [ [ 138, 142 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d727.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d727.s0.e0", "arg2_id": "BioInfer.d727.s0.e1", "normalized": [] }, { "id": "BioInfer.d727.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d727.s0.e0", "arg2_id": "BioInfer.d727.s0.e2", "normalized": [] }, { "id": "BioInfer.d727.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d727.s0.e0", "arg2_id": "BioInfer.d727.s0.e3", "normalized": [] }, { "id": "BioInfer.d727.s0.i3", "type": "PPI", "arg1_id": "BioInfer.d727.s0.e0", "arg2_id": "BioInfer.d727.s0.e4", "normalized": [] }, { "id": "BioInfer.d727.s0.i4", "type": "PPI", "arg1_id": "BioInfer.d727.s0.e0", "arg2_id": "BioInfer.d727.s0.e5", "normalized": [] }, { "id": "BioInfer.d727.s0.i5", "type": "PPI", "arg1_id": "BioInfer.d727.s0.e0", "arg2_id": "BioInfer.d727.s0.e6", "normalized": [] }, { "id": "BioInfer.d727.s0.i6", "type": "PPI", "arg1_id": "BioInfer.d727.s0.e1", "arg2_id": "BioInfer.d727.s0.e2", "normalized": [] }, { "id": "BioInfer.d727.s0.i7", "type": "PPI", "arg1_id": "BioInfer.d727.s0.e1", "arg2_id": "BioInfer.d727.s0.e3", "normalized": [] }, { "id": "BioInfer.d727.s0.i8", "type": "PPI", "arg1_id": "BioInfer.d727.s0.e1", "arg2_id": "BioInfer.d727.s0.e4", "normalized": [] }, { "id": "BioInfer.d727.s0.i9", "type": "PPI", "arg1_id": "BioInfer.d727.s0.e1", "arg2_id": "BioInfer.d727.s0.e5", "normalized": [] }, { "id": "BioInfer.d727.s0.i10", "type": "PPI", "arg1_id": "BioInfer.d727.s0.e1", "arg2_id": "BioInfer.d727.s0.e6", "normalized": [] }, { "id": "BioInfer.d727.s0.i11", "type": "PPI", "arg1_id": "BioInfer.d727.s0.e2", "arg2_id": "BioInfer.d727.s0.e5", "normalized": [] }, { "id": "BioInfer.d727.s0.i12", "type": "PPI", "arg1_id": "BioInfer.d727.s0.e2", "arg2_id": "BioInfer.d727.s0.e6", "normalized": [] }, { "id": "BioInfer.d727.s0.i13", "type": "PPI", "arg1_id": "BioInfer.d727.s0.e3", "arg2_id": "BioInfer.d727.s0.e5", "normalized": [] }, { "id": "BioInfer.d727.s0.i14", "type": "PPI", "arg1_id": "BioInfer.d727.s0.e3", "arg2_id": "BioInfer.d727.s0.e6", "normalized": [] }, { "id": "BioInfer.d727.s0.i15", "type": "PPI", "arg1_id": "BioInfer.d727.s0.e4", "arg2_id": "BioInfer.d727.s0.e5", "normalized": [] }, { "id": "BioInfer.d727.s0.i16", "type": "PPI", "arg1_id": "BioInfer.d727.s0.e4", "arg2_id": "BioInfer.d727.s0.e6", "normalized": [] }, { "id": "BioInfer.d727.s0.i17", "type": "PPI", "arg1_id": "BioInfer.d727.s0.e5", "arg2_id": "BioInfer.d727.s0.e6", "normalized": [] } ]

[ { "id": "BioInfer.d728.s0__text", "type": "Sentence", "text": [ "The two cardiac myosin heavy chain isoforms, alpha and beta, differ functionally, alpha Myosin exhibits higher actin-activated ATPase than does beta myosin, and hearts expressing alpha myosin exhibit increased contractility relative to hearts expressing beta myosin." ], "offsets": [ [ 0, 266 ] ] } ]

[ { "id": "BioInfer.d728.s0.e0", "type": "Individual_protein", "text": [ "ATPase" ], "offsets": [ [ 127, 133 ] ], "normalized": [] }, { "id": "BioInfer.d728.s0.e1", "type": "Individual_protein", "text": [ "beta myosin" ], "offsets": [ [ 144, 155 ] ], "normalized": [] }, { "id": "BioInfer.d728.s0.e2", "type": "Individual_protein", "text": [ "alpha Myosin" ], "offsets": [ [ 82, 94 ] ], "normalized": [] }, { "id": "BioInfer.d728.s0.e3", "type": "Gene/protein/RNA", "text": [ "alpha myosin" ], "offsets": [ [ 179, 191 ] ], "normalized": [] }, { "id": "BioInfer.d728.s0.e4", "type": "Gene/protein/RNA", "text": [ "beta myosin" ], "offsets": [ [ 254, 265 ] ], "normalized": [] }, { "id": "BioInfer.d728.s0.e5", "type": "Individual_protein", "text": [ "cardiac myosin heavy chain", "alpha" ], "offsets": [ [ 8, 34 ], [ 45, 50 ] ], "normalized": [] }, { "id": "BioInfer.d728.s0.e6", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 111, 116 ] ], "normalized": [] }, { "id": "BioInfer.d728.s0.e7", "type": "Individual_protein", "text": [ "cardiac myosin heavy chain", "beta" ], "offsets": [ [ 8, 34 ], [ 55, 59 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d728.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d728.s0.e0", "arg2_id": "BioInfer.d728.s0.e1", "normalized": [] }, { "id": "BioInfer.d728.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d728.s0.e0", "arg2_id": "BioInfer.d728.s0.e2", "normalized": [] }, { "id": "BioInfer.d728.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d728.s0.e0", "arg2_id": "BioInfer.d728.s0.e6", "normalized": [] }, { "id": "BioInfer.d728.s0.i3", "type": "PPI", "arg1_id": "BioInfer.d728.s0.e5", "arg2_id": "BioInfer.d728.s0.e7", "normalized": [] } ]

[ { "id": "BioInfer.d729.s0__text", "type": "Sentence", "text": [ "The two proteins were found to differ in their interaction with actin, like destrin and cofilin isolated from porcine brain." ], "offsets": [ [ 0, 124 ] ] } ]

[ { "id": "BioInfer.d729.s0.e0", "type": "Individual_protein", "text": [ "cofilin" ], "offsets": [ [ 88, 95 ] ], "normalized": [] }, { "id": "BioInfer.d729.s0.e1", "type": "Individual_protein", "text": [ "destrin" ], "offsets": [ [ 76, 83 ] ], "normalized": [] }, { "id": "BioInfer.d729.s0.e2", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 64, 69 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d729.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d729.s0.e0", "arg2_id": "BioInfer.d729.s0.e1", "normalized": [] }, { "id": "BioInfer.d729.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d729.s0.e0", "arg2_id": "BioInfer.d729.s0.e2", "normalized": [] }, { "id": "BioInfer.d729.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d729.s0.e1", "arg2_id": "BioInfer.d729.s0.e2", "normalized": [] } ]

[ { "id": "BioInfer.d730.s0__text", "type": "Sentence", "text": [ "The undifferentiated cells (a) were unable to spread on gelatin or laminin and grew as rounded colonies, although they were able to spread on fibronectin (b) showed reduced adhesion to laminin, but not fibronectin (c) expressed much reduced levels of beta1 integrin, although levels of alpha5 and alphaV were wild-type (d) were less polarized with increased membrane protrusions compared with a vinculin (-/-) ES cell mutant (e) were unable to assemble vinculin or paxillin-containing focal adhesions or actin stress fibers on fibronectin, whereas vinculin (-/-) ES cells were able to assemble talin-containing focal adhesions." ], "offsets": [ [ 0, 627 ] ] } ]

[ { "id": "BioInfer.d730.s0.e0", "type": "Gene/protein/RNA", "text": [ "actin" ], "offsets": [ [ 504, 509 ] ], "normalized": [] }, { "id": "BioInfer.d730.s0.e1", "type": "Gene/protein/RNA", "text": [ "talin" ], "offsets": [ [ 594, 599 ] ], "normalized": [] }, { "id": "BioInfer.d730.s0.e2", "type": "Gene/protein/RNA", "text": [ "vinculin" ], "offsets": [ [ 548, 556 ] ], "normalized": [] }, { "id": "BioInfer.d730.s0.e3", "type": "Gene/protein/RNA", "text": [ "vinculin" ], "offsets": [ [ 453, 461 ] ], "normalized": [] }, { "id": "BioInfer.d730.s0.e4", "type": "Gene/protein/RNA", "text": [ "fibronectin" ], "offsets": [ [ 527, 538 ] ], "normalized": [] }, { "id": "BioInfer.d730.s0.e5", "type": "Gene/protein/RNA", "text": [ "laminin" ], "offsets": [ [ 67, 74 ] ], "normalized": [] }, { "id": "BioInfer.d730.s0.e6", "type": "Gene/protein/RNA", "text": [ "fibronectin" ], "offsets": [ [ 202, 213 ] ], "normalized": [] }, { "id": "BioInfer.d730.s0.e7", "type": "Gene/protein/RNA", "text": [ "gelatin" ], "offsets": [ [ 56, 63 ] ], "normalized": [] }, { "id": "BioInfer.d730.s0.e8", "type": "Gene/protein/RNA", "text": [ "fibronectin" ], "offsets": [ [ 142, 153 ] ], "normalized": [] }, { "id": "BioInfer.d730.s0.e9", "type": "Gene/protein/RNA", "text": [ "beta1 integrin" ], "offsets": [ [ 251, 265 ] ], "normalized": [] }, { "id": "BioInfer.d730.s0.e10", "type": "Gene/protein/RNA", "text": [ "paxillin" ], "offsets": [ [ 465, 473 ] ], "normalized": [] }, { "id": "BioInfer.d730.s0.e11", "type": "Gene/protein/RNA", "text": [ "laminin" ], "offsets": [ [ 185, 192 ] ], "normalized": [] }, { "id": "BioInfer.d730.s0.e12", "type": "Gene/protein/RNA", "text": [ "vinculin" ], "offsets": [ [ 395, 403 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d731.s0__text", "type": "Sentence", "text": [ "The vaccinia virus E3L gene product, pE3, is a dsRNA binding protein that prevents activation of the interferon-induced, dsRNA-activated protein kinase, PKR." ], "offsets": [ [ 0, 157 ] ] } ]

[ { "id": "BioInfer.d731.s0.e0", "type": "Gene", "text": [ "E3L" ], "offsets": [ [ 19, 22 ] ], "normalized": [] }, { "id": "BioInfer.d731.s0.e1", "type": "Protein_family_or_group", "text": [ "protein kinase" ], "offsets": [ [ 137, 151 ] ], "normalized": [] }, { "id": "BioInfer.d731.s0.e2", "type": "Individual_protein", "text": [ "pE3" ], "offsets": [ [ 37, 40 ] ], "normalized": [] }, { "id": "BioInfer.d731.s0.e3", "type": "Individual_protein", "text": [ "interferon" ], "offsets": [ [ 101, 111 ] ], "normalized": [] }, { "id": "BioInfer.d731.s0.e4", "type": "Individual_protein", "text": [ "PKR" ], "offsets": [ [ 153, 156 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d731.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d731.s0.e0", "arg2_id": "BioInfer.d731.s0.e4", "normalized": [] }, { "id": "BioInfer.d731.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d731.s0.e1", "arg2_id": "BioInfer.d731.s0.e4", "normalized": [] }, { "id": "BioInfer.d731.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d731.s0.e2", "arg2_id": "BioInfer.d731.s0.e4", "normalized": [] }, { "id": "BioInfer.d731.s0.i3", "type": "PPI", "arg1_id": "BioInfer.d731.s0.e3", "arg2_id": "BioInfer.d731.s0.e4", "normalized": [] } ]

[ { "id": "BioInfer.d732.s0__text", "type": "Sentence", "text": [ "The yeast two-hybrid system was used to identify domains involved in specific in vivo interactions between the Rinderpest virus (RPV) phosphoprotein (P) and nucleocapsid protein (N)." ], "offsets": [ [ 0, 182 ] ] } ]

[ { "id": "BioInfer.d732.s0.e0", "type": "Individual_protein", "text": [ "nucleocapsid protein" ], "offsets": [ [ 157, 177 ] ], "normalized": [] }, { "id": "BioInfer.d732.s0.e1", "type": "Individual_protein", "text": [ "phosphoprotein" ], "offsets": [ [ 134, 148 ] ], "normalized": [] }, { "id": "BioInfer.d732.s0.e2", "type": "Individual_protein", "text": [ "P" ], "offsets": [ [ 150, 151 ] ], "normalized": [] }, { "id": "BioInfer.d732.s0.e3", "type": "Individual_protein", "text": [ "N" ], "offsets": [ [ 179, 180 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d732.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d732.s0.e0", "arg2_id": "BioInfer.d732.s0.e1", "normalized": [] }, { "id": "BioInfer.d732.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d732.s0.e0", "arg2_id": "BioInfer.d732.s0.e2", "normalized": [] }, { "id": "BioInfer.d732.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d732.s0.e1", "arg2_id": "BioInfer.d732.s0.e3", "normalized": [] }, { "id": "BioInfer.d732.s0.i3", "type": "PPI", "arg1_id": "BioInfer.d732.s0.e2", "arg2_id": "BioInfer.d732.s0.e3", "normalized": [] } ]

[ { "id": "BioInfer.d733.s0__text", "type": "Sentence", "text": [ "They exhibited strong synergistic increases in CAN1 duplication mutations, intrachromosomal and interchromosomal recombination, and required the wild-type double-strand break repair genes RAD50, RAD51, and RAD52 for viability." ], "offsets": [ [ 0, 226 ] ] } ]

[ { "id": "BioInfer.d733.s0.e0", "type": "Gene/protein/RNA", "text": [ "RAD52" ], "offsets": [ [ 206, 211 ] ], "normalized": [] }, { "id": "BioInfer.d733.s0.e1", "type": "Gene/protein/RNA", "text": [ "RAD50" ], "offsets": [ [ 188, 193 ] ], "normalized": [] }, { "id": "BioInfer.d733.s0.e2", "type": "Gene/protein/RNA", "text": [ "RAD51" ], "offsets": [ [ 195, 200 ] ], "normalized": [] }, { "id": "BioInfer.d733.s0.e3", "type": "Gene/protein/RNA", "text": [ "CAN1" ], "offsets": [ [ 47, 51 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d734.s0__text", "type": "Sentence", "text": [ "They had altered adhesive properties as measured by their ability to bind to a fibronectin-coated glass surface, suggesting that the expression of a rac-1 GAP alters the assembly of integrin receptors, actin and cytoskeletal proteins such as vinculin and talin." ], "offsets": [ [ 0, 261 ] ] } ]

[ { "id": "BioInfer.d734.s0.e0", "type": "Individual_protein", "text": [ "integrin" ], "offsets": [ [ 182, 190 ] ], "normalized": [] }, { "id": "BioInfer.d734.s0.e1", "type": "Individual_protein", "text": [ "talin" ], "offsets": [ [ 255, 260 ] ], "normalized": [] }, { "id": "BioInfer.d734.s0.e2", "type": "Individual_protein", "text": [ "vinculin" ], "offsets": [ [ 242, 250 ] ], "normalized": [] }, { "id": "BioInfer.d734.s0.e3", "type": "Gene/protein/RNA", "text": [ "fibronectin" ], "offsets": [ [ 79, 90 ] ], "normalized": [] }, { "id": "BioInfer.d734.s0.e4", "type": "Individual_protein", "text": [ "rac-1 GAP" ], "offsets": [ [ 149, 158 ] ], "normalized": [] }, { "id": "BioInfer.d734.s0.e5", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 202, 207 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d734.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d734.s0.e0", "arg2_id": "BioInfer.d734.s0.e4", "normalized": [] }, { "id": "BioInfer.d734.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d734.s0.e1", "arg2_id": "BioInfer.d734.s0.e4", "normalized": [] }, { "id": "BioInfer.d734.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d734.s0.e2", "arg2_id": "BioInfer.d734.s0.e4", "normalized": [] }, { "id": "BioInfer.d734.s0.i3", "type": "PPI", "arg1_id": "BioInfer.d734.s0.e4", "arg2_id": "BioInfer.d734.s0.e5", "normalized": [] } ]

[ { "id": "BioInfer.d735.s0__text", "type": "Sentence", "text": [ "This activity is independent of FADD-DN's ability to bind to three known interacting proteins, Fas, TRADD or RIP suggesting that it is distinct from FADD's functions at activated death receptors." ], "offsets": [ [ 0, 195 ] ] } ]

[ { "id": "BioInfer.d735.s0.e0", "type": "Individual_protein", "text": [ "RIP" ], "offsets": [ [ 109, 112 ] ], "normalized": [] }, { "id": "BioInfer.d735.s0.e1", "type": "Individual_protein", "text": [ "FADD" ], "offsets": [ [ 149, 153 ] ], "normalized": [] }, { "id": "BioInfer.d735.s0.e2", "type": "Individual_protein", "text": [ "Fas" ], "offsets": [ [ 95, 98 ] ], "normalized": [] }, { "id": "BioInfer.d735.s0.e3", "type": "Individual_protein", "text": [ "FADD-DN" ], "offsets": [ [ 32, 39 ] ], "normalized": [] }, { "id": "BioInfer.d735.s0.e4", "type": "Protein_family_or_group", "text": [ "death receptors" ], "offsets": [ [ 179, 194 ] ], "normalized": [] }, { "id": "BioInfer.d735.s0.e5", "type": "Individual_protein", "text": [ "TRADD" ], "offsets": [ [ 100, 105 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d735.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d735.s0.e0", "arg2_id": "BioInfer.d735.s0.e2", "normalized": [] }, { "id": "BioInfer.d735.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d735.s0.e0", "arg2_id": "BioInfer.d735.s0.e3", "normalized": [] }, { "id": "BioInfer.d735.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d735.s0.e0", "arg2_id": "BioInfer.d735.s0.e5", "normalized": [] }, { "id": "BioInfer.d735.s0.i3", "type": "PPI", "arg1_id": "BioInfer.d735.s0.e1", "arg2_id": "BioInfer.d735.s0.e4", "normalized": [] }, { "id": "BioInfer.d735.s0.i4", "type": "PPI", "arg1_id": "BioInfer.d735.s0.e2", "arg2_id": "BioInfer.d735.s0.e3", "normalized": [] }, { "id": "BioInfer.d735.s0.i5", "type": "PPI", "arg1_id": "BioInfer.d735.s0.e2", "arg2_id": "BioInfer.d735.s0.e5", "normalized": [] }, { "id": "BioInfer.d735.s0.i6", "type": "PPI", "arg1_id": "BioInfer.d735.s0.e3", "arg2_id": "BioInfer.d735.s0.e5", "normalized": [] } ]

[ { "id": "BioInfer.d736.s0__text", "type": "Sentence", "text": [ "This approach is based on the assumption that an actin mutation that specifically impairs the interaction with an actin-binding protein will cause a phenotype similar to a null mutation in the gene that encodes the actin-binding protein." ], "offsets": [ [ 0, 237 ] ] } ]

[ { "id": "BioInfer.d736.s0.e0", "type": "Gene/protein/RNA", "text": [ "actin-binding protein" ], "offsets": [ [ 215, 236 ] ], "normalized": [] }, { "id": "BioInfer.d736.s0.e1", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 49, 54 ] ], "normalized": [] }, { "id": "BioInfer.d736.s0.e2", "type": "Individual_protein", "text": [ "actin-binding protein" ], "offsets": [ [ 114, 135 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d736.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d736.s0.e1", "arg2_id": "BioInfer.d736.s0.e2", "normalized": [] } ]

[ { "id": "BioInfer.d736.s1__text", "type": "Sentence", "text": [ "21 actin mutations were analyzed in budding yeast, and specific regions of actin subdomain 1 were implicated in the interaction with fimbrin, an actin filament-bundling protein." ], "offsets": [ [ 0, 177 ] ] } ]

[ { "id": "BioInfer.d736.s1.e0", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 75, 80 ] ], "normalized": [] }, { "id": "BioInfer.d736.s1.e1", "type": "Gene/protein/RNA", "text": [ "actin" ], "offsets": [ [ 3, 8 ] ], "normalized": [] }, { "id": "BioInfer.d736.s1.e2", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 145, 150 ] ], "normalized": [] }, { "id": "BioInfer.d736.s1.e3", "type": "Individual_protein", "text": [ "fimbrin" ], "offsets": [ [ 133, 140 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d736.s1.i0", "type": "PPI", "arg1_id": "BioInfer.d736.s1.e0", "arg2_id": "BioInfer.d736.s1.e3", "normalized": [] }, { "id": "BioInfer.d736.s1.i1", "type": "PPI", "arg1_id": "BioInfer.d736.s1.e2", "arg2_id": "BioInfer.d736.s1.e3", "normalized": [] } ]

[ { "id": "BioInfer.d737.s0__text", "type": "Sentence", "text": [ "This arrest can be suppressed by mutations in RAD51, RAD52, and RAD57, suggesting that the cell cycle defect in sgs1 srs2 mutants results from inappropriate homologous recombination." ], "offsets": [ [ 0, 182 ] ] } ]

[ { "id": "BioInfer.d737.s0.e0", "type": "Gene/protein/RNA", "text": [ "sgs1" ], "offsets": [ [ 112, 116 ] ], "normalized": [] }, { "id": "BioInfer.d737.s0.e1", "type": "Gene/protein/RNA", "text": [ "srs2" ], "offsets": [ [ 117, 121 ] ], "normalized": [] }, { "id": "BioInfer.d737.s0.e2", "type": "Gene/protein/RNA", "text": [ "RAD52" ], "offsets": [ [ 53, 58 ] ], "normalized": [] }, { "id": "BioInfer.d737.s0.e3", "type": "Gene/protein/RNA", "text": [ "RAD57" ], "offsets": [ [ 64, 69 ] ], "normalized": [] }, { "id": "BioInfer.d737.s0.e4", "type": "Gene/protein/RNA", "text": [ "RAD51" ], "offsets": [ [ 46, 51 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d739.s0__text", "type": "Sentence", "text": [ "This filament growth is driven by a large storage pool of actin bound to the sequestering protein, profilin." ], "offsets": [ [ 0, 108 ] ] } ]

[ { "id": "BioInfer.d739.s0.e0", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 58, 63 ] ], "normalized": [] }, { "id": "BioInfer.d739.s0.e1", "type": "Individual_protein", "text": [ "profilin" ], "offsets": [ [ 99, 107 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d739.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d739.s0.e0", "arg2_id": "BioInfer.d739.s0.e1", "normalized": [] } ]

[ { "id": "BioInfer.d740.s0__text", "type": "Sentence", "text": [ "This is consistent with cofilin activation being required for actin reorganization during exocytosis." ], "offsets": [ [ 0, 101 ] ] } ]

[ { "id": "BioInfer.d740.s0.e0", "type": "Individual_protein", "text": [ "cofilin" ], "offsets": [ [ 24, 31 ] ], "normalized": [] }, { "id": "BioInfer.d740.s0.e1", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 62, 67 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d740.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d740.s0.e0", "arg2_id": "BioInfer.d740.s0.e1", "normalized": [] } ]

[ { "id": "BioInfer.d741.s0__text", "type": "Sentence", "text": [ "This is the first report describing the coexistence of profilin with actin filaments in the division furrow, implying the possible involvement of profilin in assembly and disassembly of contractile ring microfilaments in the process of cytokinesis." ], "offsets": [ [ 0, 248 ] ] } ]

[ { "id": "BioInfer.d741.s0.e0", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 69, 74 ] ], "normalized": [] }, { "id": "BioInfer.d741.s0.e1", "type": "Gene/protein/RNA", "text": [ "profilin" ], "offsets": [ [ 146, 154 ] ], "normalized": [] }, { "id": "BioInfer.d741.s0.e2", "type": "Individual_protein", "text": [ "profilin" ], "offsets": [ [ 55, 63 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d741.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d741.s0.e0", "arg2_id": "BioInfer.d741.s0.e2", "normalized": [] } ]

[ { "id": "BioInfer.d742.s0__text", "type": "Sentence", "text": [ "This novel mutation was predicted to disrupt the binding of beta-catenin to alpha-catenin and may be related to the diffuse type morphology." ], "offsets": [ [ 0, 140 ] ] } ]

[ { "id": "BioInfer.d742.s0.e0", "type": "Individual_protein", "text": [ "alpha-catenin" ], "offsets": [ [ 76, 89 ] ], "normalized": [] }, { "id": "BioInfer.d742.s0.e1", "type": "Individual_protein", "text": [ "beta-catenin" ], "offsets": [ [ 60, 72 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d742.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d742.s0.e0", "arg2_id": "BioInfer.d742.s0.e1", "normalized": [] } ]

[ { "id": "BioInfer.d746.s0__text", "type": "Sentence", "text": [ "This shows that structural changes in the poly(L-proline)-binding region of profilin can affect the distantly located actin-binding site." ], "offsets": [ [ 0, 137 ] ] } ]

[ { "id": "BioInfer.d746.s0.e0", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 118, 123 ] ], "normalized": [] }, { "id": "BioInfer.d746.s0.e1", "type": "Individual_protein", "text": [ "profilin" ], "offsets": [ [ 76, 84 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d746.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d746.s0.e0", "arg2_id": "BioInfer.d746.s0.e1", "normalized": [] } ]

[ { "id": "BioInfer.d747.s0__text", "type": "Sentence", "text": [ "This technique was employed to quantify changes caused by the lack of talin, a protein that couples the actin network to the plasma membrane, or by the lack of cortexillin I or II, two isoforms of the actin-bundling protein cortexillin." ], "offsets": [ [ 0, 236 ] ] } ]

[ { "id": "BioInfer.d747.s0.e0", "type": "Individual_protein", "text": [ "cortexillin" ], "offsets": [ [ 224, 235 ] ], "normalized": [] }, { "id": "BioInfer.d747.s0.e1", "type": "Individual_protein", "text": [ "cortexillin I" ], "offsets": [ [ 160, 173 ] ], "normalized": [] }, { "id": "BioInfer.d747.s0.e2", "type": "Individual_protein", "text": [ "talin" ], "offsets": [ [ 70, 75 ] ], "normalized": [] }, { "id": "BioInfer.d747.s0.e3", "type": "Individual_protein", "text": [ "cortexillin", "II" ], "offsets": [ [ 160, 171 ], [ 177, 179 ] ], "normalized": [] }, { "id": "BioInfer.d747.s0.e4", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 201, 206 ] ], "normalized": [] }, { "id": "BioInfer.d747.s0.e5", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 104, 109 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d747.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d747.s0.e0", "arg2_id": "BioInfer.d747.s0.e1", "normalized": [] }, { "id": "BioInfer.d747.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d747.s0.e0", "arg2_id": "BioInfer.d747.s0.e3", "normalized": [] }, { "id": "BioInfer.d747.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d747.s0.e0", "arg2_id": "BioInfer.d747.s0.e4", "normalized": [] }, { "id": "BioInfer.d747.s0.i3", "type": "PPI", "arg1_id": "BioInfer.d747.s0.e2", "arg2_id": "BioInfer.d747.s0.e5", "normalized": [] } ]

[ { "id": "BioInfer.d749.s0__text", "type": "Sentence", "text": [ "Three actin-associated proteins, actin-binding protein, gelsolin, and profilin, influence gelation, solation, and polymerization, respectively, of actin in vitro." ], "offsets": [ [ 0, 162 ] ] } ]

[ { "id": "BioInfer.d749.s0.e0", "type": "Individual_protein", "text": [ "gelsolin" ], "offsets": [ [ 56, 64 ] ], "normalized": [] }, { "id": "BioInfer.d749.s0.e1", "type": "Individual_protein", "text": [ "actin-binding protein" ], "offsets": [ [ 33, 54 ] ], "normalized": [] }, { "id": "BioInfer.d749.s0.e2", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 6, 11 ] ], "normalized": [] }, { "id": "BioInfer.d749.s0.e3", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 147, 152 ] ], "normalized": [] }, { "id": "BioInfer.d749.s0.e4", "type": "Individual_protein", "text": [ "profilin" ], "offsets": [ [ 70, 78 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d749.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d749.s0.e0", "arg2_id": "BioInfer.d749.s0.e2", "normalized": [] }, { "id": "BioInfer.d749.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d749.s0.e1", "arg2_id": "BioInfer.d749.s0.e2", "normalized": [] }, { "id": "BioInfer.d749.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d749.s0.e2", "arg2_id": "BioInfer.d749.s0.e4", "normalized": [] }, { "id": "BioInfer.d749.s0.i3", "type": "PPI", "arg1_id": "BioInfer.d749.s0.e3", "arg2_id": "BioInfer.d749.s0.e4", "normalized": [] } ]

[ { "id": "BioInfer.d750.s0__text", "type": "Sentence", "text": [ "Three components of Drosophila adherens junctions, analogous to those in vertebrates, have been identified: Armadillo (homolog of beta-catenin), Drosophila E-cadherin (DE-cadherin), and alpha-catenin." ], "offsets": [ [ 0, 200 ] ] } ]

[ { "id": "BioInfer.d750.s0.e0", "type": "Individual_protein", "text": [ "E-cadherin" ], "offsets": [ [ 156, 166 ] ], "normalized": [] }, { "id": "BioInfer.d750.s0.e1", "type": "Individual_protein", "text": [ "Armadillo" ], "offsets": [ [ 108, 117 ] ], "normalized": [] }, { "id": "BioInfer.d750.s0.e2", "type": "Gene/protein/RNA", "text": [ "alpha-catenin" ], "offsets": [ [ 186, 199 ] ], "normalized": [] }, { "id": "BioInfer.d750.s0.e3", "type": "Individual_protein", "text": [ "beta-catenin" ], "offsets": [ [ 130, 142 ] ], "normalized": [] }, { "id": "BioInfer.d750.s0.e4", "type": "Individual_protein", "text": [ "DE-cadherin" ], "offsets": [ [ 168, 179 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d750.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d750.s0.e1", "arg2_id": "BioInfer.d750.s0.e3", "normalized": [] } ]

[ { "id": "BioInfer.d751.s0__text", "type": "Sentence", "text": [ "Thus, actin was found in association with fimbrin in the mechanoreceptive region of hair cells, whereas supporting cells, although rich in actin, did not reveal fimbrin." ], "offsets": [ [ 0, 169 ] ] } ]

[ { "id": "BioInfer.d751.s0.e0", "type": "Individual_protein", "text": [ "fimbrin" ], "offsets": [ [ 42, 49 ] ], "normalized": [] }, { "id": "BioInfer.d751.s0.e1", "type": "Gene/protein/RNA", "text": [ "actin" ], "offsets": [ [ 139, 144 ] ], "normalized": [] }, { "id": "BioInfer.d751.s0.e2", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 6, 11 ] ], "normalized": [] }, { "id": "BioInfer.d751.s0.e3", "type": "Gene/protein/RNA", "text": [ "fimbrin" ], "offsets": [ [ 161, 168 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d751.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d751.s0.e0", "arg2_id": "BioInfer.d751.s0.e2", "normalized": [] } ]

[ { "id": "BioInfer.d752.s0__text", "type": "Sentence", "text": [ "Thus, beta-catenin, E-cadherin, and alpha-catenin have similar prognostic values." ], "offsets": [ [ 0, 81 ] ] } ]

[ { "id": "BioInfer.d752.s0.e0", "type": "Gene/protein/RNA", "text": [ "alpha-catenin" ], "offsets": [ [ 36, 49 ] ], "normalized": [] }, { "id": "BioInfer.d752.s0.e1", "type": "Gene/protein/RNA", "text": [ "beta-catenin" ], "offsets": [ [ 6, 18 ] ], "normalized": [] }, { "id": "BioInfer.d752.s0.e2", "type": "Gene/protein/RNA", "text": [ "E-cadherin" ], "offsets": [ [ 20, 30 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d755.s0__text", "type": "Sentence", "text": [ "Thus, mHip1R contains an NH(2)-terminal domain homologous to that implicated in Sla2p's endocytic function, three predicted coiled-coils, a leucine zipper, and a talin-like actin-binding domain at the COOH terminus." ], "offsets": [ [ 0, 215 ] ] } ]

[ { "id": "BioInfer.d755.s0.e0", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 173, 178 ] ], "normalized": [] }, { "id": "BioInfer.d755.s0.e1", "type": "Individual_protein", "text": [ "Sla2p" ], "offsets": [ [ 80, 85 ] ], "normalized": [] }, { "id": "BioInfer.d755.s0.e2", "type": "Individual_protein", "text": [ "talin" ], "offsets": [ [ 162, 167 ] ], "normalized": [] }, { "id": "BioInfer.d755.s0.e3", "type": "Individual_protein", "text": [ "mHip1R" ], "offsets": [ [ 6, 12 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d755.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d755.s0.e0", "arg2_id": "BioInfer.d755.s0.e3", "normalized": [] }, { "id": "BioInfer.d755.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d755.s0.e1", "arg2_id": "BioInfer.d755.s0.e3", "normalized": [] }, { "id": "BioInfer.d755.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d755.s0.e2", "arg2_id": "BioInfer.d755.s0.e3", "normalized": [] } ]

[ { "id": "BioInfer.d756.s0__text", "type": "Sentence", "text": [ "Thus, poly-L-proline binding, actin binding, and actin nucleotide exchange are each independent requirements for profilin function in fission yeast." ], "offsets": [ [ 0, 148 ] ] } ]

[ { "id": "BioInfer.d756.s0.e0", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 30, 35 ] ], "normalized": [] }, { "id": "BioInfer.d756.s0.e1", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 49, 54 ] ], "normalized": [] }, { "id": "BioInfer.d756.s0.e2", "type": "Individual_protein", "text": [ "profilin" ], "offsets": [ [ 113, 121 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d756.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d756.s0.e0", "arg2_id": "BioInfer.d756.s0.e2", "normalized": [] }, { "id": "BioInfer.d756.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d756.s0.e1", "arg2_id": "BioInfer.d756.s0.e2", "normalized": [] } ]

[ { "id": "BioInfer.d757.s0__text", "type": "Sentence", "text": [ "Thus, the actin-binding dodecapeptide sequence of cofilin may constitute a multifunctional domain in cofilin." ], "offsets": [ [ 0, 109 ] ] } ]

[ { "id": "BioInfer.d757.s0.e0", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 10, 15 ] ], "normalized": [] }, { "id": "BioInfer.d757.s0.e1", "type": "Individual_protein", "text": [ "cofilin" ], "offsets": [ [ 50, 57 ] ], "normalized": [] }, { "id": "BioInfer.d757.s0.e2", "type": "Individual_protein", "text": [ "cofilin" ], "offsets": [ [ 101, 108 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d757.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d757.s0.e0", "arg2_id": "BioInfer.d757.s0.e1", "normalized": [] } ]

[ { "id": "BioInfer.d757.s1__text", "type": "Sentence", "text": [ "We have previously shown that the synthetic dodecapeptide corresponding to Trp104-Met115 of cofilin is a potent inhibitor of actin polymerization (Yonezawa, N., Nishida, E., Iida, K., Kumagai, H., Yahara, I., and Sakai, H. (1991) J. Biol. Chem. 266, 10485-10489)." ], "offsets": [ [ 0, 263 ] ] } ]

[ { "id": "BioInfer.d757.s1.e0", "type": "Individual_protein", "text": [ "cofilin" ], "offsets": [ [ 92, 99 ] ], "normalized": [] }, { "id": "BioInfer.d757.s1.e1", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 125, 130 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d757.s1.i0", "type": "PPI", "arg1_id": "BioInfer.d757.s1.e0", "arg2_id": "BioInfer.d757.s1.e1", "normalized": [] } ]

[ { "id": "BioInfer.d758.s0__text", "type": "Sentence", "text": [ "TNF also inhibited muscle differentiation as measured by several parameters, including cell fusion and the expression of other muscle-specific genes, such as alpha-skeletal actin and myosin heavy chain." ], "offsets": [ [ 0, 202 ] ] } ]

[ { "id": "BioInfer.d758.s0.e0", "type": "Gene/protein/RNA", "text": [ "TNF" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "BioInfer.d758.s0.e1", "type": "Gene/protein/RNA", "text": [ "myosin heavy chain" ], "offsets": [ [ 183, 201 ] ], "normalized": [] }, { "id": "BioInfer.d758.s0.e2", "type": "Gene/protein/RNA", "text": [ "alpha-skeletal actin" ], "offsets": [ [ 158, 178 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d760.s0__text", "type": "Sentence", "text": [ "To characterize the AAV functions mediating this effect, cloned AAV type 2 wild-type or mutant genomes were transfected into simian virus 40 (SV40)-transformed hamster cells together with the six HSV replication genes (encoding UL5, UL8, major DNA-binding protein, DNA polymerase, UL42, and UL52) which together are necessary and sufficient for the induction of SV40 DNA amplification (R. Heilbronn and H. zur Hausen, J. Virol. 63:3683-3692, 1989)." ], "offsets": [ [ 0, 448 ] ] } ]

[ { "id": "BioInfer.d760.s0.e0", "type": "Gene/protein/RNA", "text": [ "DNA polymerase" ], "offsets": [ [ 265, 279 ] ], "normalized": [] }, { "id": "BioInfer.d760.s0.e1", "type": "Gene/protein/RNA", "text": [ "major DNA-binding protein" ], "offsets": [ [ 238, 263 ] ], "normalized": [] }, { "id": "BioInfer.d760.s0.e2", "type": "Gene/protein/RNA", "text": [ "UL8" ], "offsets": [ [ 233, 236 ] ], "normalized": [] }, { "id": "BioInfer.d760.s0.e3", "type": "Gene/protein/RNA", "text": [ "UL5" ], "offsets": [ [ 228, 231 ] ], "normalized": [] }, { "id": "BioInfer.d760.s0.e4", "type": "Gene/protein/RNA", "text": [ "UL52" ], "offsets": [ [ 291, 295 ] ], "normalized": [] }, { "id": "BioInfer.d760.s0.e5", "type": "Gene/protein/RNA", "text": [ "UL42" ], "offsets": [ [ 281, 285 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d761.s0__text", "type": "Sentence", "text": [ "To characterize the phenotypic alteration in mesangial cells in human glomerulonephritis, we investigated the expression of nonmuscle-type myosin heavy chain, SMemb, and alpha-smooth muscle actin (alpha-SM actin) in IgA nephropathy." ], "offsets": [ [ 0, 232 ] ] } ]

[ { "id": "BioInfer.d761.s0.e0", "type": "Gene/protein/RNA", "text": [ "IgA" ], "offsets": [ [ 216, 219 ] ], "normalized": [] }, { "id": "BioInfer.d761.s0.e1", "type": "Individual_protein", "text": [ "alpha-smooth muscle actin" ], "offsets": [ [ 170, 195 ] ], "normalized": [] }, { "id": "BioInfer.d761.s0.e2", "type": "Gene/protein/RNA", "text": [ "nonmuscle-type myosin heavy chain" ], "offsets": [ [ 124, 157 ] ], "normalized": [] }, { "id": "BioInfer.d761.s0.e3", "type": "Individual_protein", "text": [ "alpha-SM actin" ], "offsets": [ [ 197, 211 ] ], "normalized": [] }, { "id": "BioInfer.d761.s0.e4", "type": "Gene/protein/RNA", "text": [ "SMemb" ], "offsets": [ [ 159, 164 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d762.s0__text", "type": "Sentence", "text": [ "To check its applicability, well characterized, commercially available antibodies (against E-cadherin, alpha-catenin, and beta-catenin) were used on sections of human small intestine." ], "offsets": [ [ 0, 183 ] ] } ]

[ { "id": "BioInfer.d762.s0.e0", "type": "Gene/protein/RNA", "text": [ "alpha-catenin" ], "offsets": [ [ 103, 116 ] ], "normalized": [] }, { "id": "BioInfer.d762.s0.e1", "type": "Gene/protein/RNA", "text": [ "beta-catenin" ], "offsets": [ [ 122, 134 ] ], "normalized": [] }, { "id": "BioInfer.d762.s0.e2", "type": "Gene/protein/RNA", "text": [ "E-cadherin" ], "offsets": [ [ 91, 101 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d763.s0__text", "type": "Sentence", "text": [ "To clarify the relation between alteration of expression of cell adhesion molecules and progression of extrahepatic bile duct carcinomas 55 cases were immunohistochemically examined for E-cadherin, alpha-catenin, beta-catenin, and CD44, with additional reverse transcription-polymerase chain reaction and Southern blotting hybridization (RT-PCR/SBH) assays." ], "offsets": [ [ 0, 357 ] ] } ]

[ { "id": "BioInfer.d763.s0.e0", "type": "Gene/protein/RNA", "text": [ "CD44" ], "offsets": [ [ 231, 235 ] ], "normalized": [] }, { "id": "BioInfer.d763.s0.e1", "type": "Gene/protein/RNA", "text": [ "polymerase" ], "offsets": [ [ 275, 285 ] ], "normalized": [] }, { "id": "BioInfer.d763.s0.e2", "type": "Gene/protein/RNA", "text": [ "alpha-catenin" ], "offsets": [ [ 198, 211 ] ], "normalized": [] }, { "id": "BioInfer.d763.s0.e3", "type": "Gene/protein/RNA", "text": [ "cell adhesion molecules" ], "offsets": [ [ 60, 83 ] ], "normalized": [] }, { "id": "BioInfer.d763.s0.e4", "type": "Gene/protein/RNA", "text": [ "E-cadherin" ], "offsets": [ [ 186, 196 ] ], "normalized": [] }, { "id": "BioInfer.d763.s0.e5", "type": "Gene/protein/RNA", "text": [ "beta-catenin" ], "offsets": [ [ 213, 225 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d764.s0__text", "type": "Sentence", "text": [ "To determine the phenotypes of smooth muscle cells (SMCs) in such lesions, the authors conducted an immunohistochemical analysis of lung tissues from two patients with PPH, using two antimuscle actin antibodies, HHF35 and CGA7, and two anti-SMC myosin heavy chain markers, anti-SM1 and anti-SM2 antibodies and related antibodies." ], "offsets": [ [ 0, 329 ] ] } ]

[ { "id": "BioInfer.d764.s0.e0", "type": "Individual_protein", "text": [ "HHF35" ], "offsets": [ [ 212, 217 ] ], "normalized": [] }, { "id": "BioInfer.d764.s0.e1", "type": "Gene/protein/RNA", "text": [ "SM1" ], "offsets": [ [ 278, 281 ] ], "normalized": [] }, { "id": "BioInfer.d764.s0.e2", "type": "Gene/protein/RNA", "text": [ "SMC myosin heavy chain" ], "offsets": [ [ 241, 263 ] ], "normalized": [] }, { "id": "BioInfer.d764.s0.e3", "type": "Gene/protein/RNA", "text": [ "SM2" ], "offsets": [ [ 291, 294 ] ], "normalized": [] }, { "id": "BioInfer.d764.s0.e4", "type": "Individual_protein", "text": [ "CGA7" ], "offsets": [ [ 222, 226 ] ], "normalized": [] }, { "id": "BioInfer.d764.s0.e5", "type": "Individual_protein", "text": [ "muscle actin" ], "offsets": [ [ 187, 199 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d764.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d764.s0.e0", "arg2_id": "BioInfer.d764.s0.e5", "normalized": [] }, { "id": "BioInfer.d764.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d764.s0.e4", "arg2_id": "BioInfer.d764.s0.e5", "normalized": [] } ]

[ { "id": "BioInfer.d765.s0__text", "type": "Sentence", "text": [ "To determine the relationship between cell cycle regulation and differentiation, the spatiotemporal expression of cyclin A, cyclin B1, cyclin D1, the cyclin-dependent kinase inhibitors (CKIs) p27 and p57, and markers of differentiating podocytes in developing human kidneys was investigated by immunohistochemistry." ], "offsets": [ [ 0, 315 ] ] } ]

[ { "id": "BioInfer.d765.s0.e0", "type": "Individual_protein", "text": [ "p27" ], "offsets": [ [ 192, 195 ] ], "normalized": [] }, { "id": "BioInfer.d765.s0.e1", "type": "Protein_family_or_group", "text": [ "CKIs" ], "offsets": [ [ 186, 190 ] ], "normalized": [] }, { "id": "BioInfer.d765.s0.e2", "type": "Protein_family_or_group", "text": [ "cyclin-dependent kinase inhibitors" ], "offsets": [ [ 150, 184 ] ], "normalized": [] }, { "id": "BioInfer.d765.s0.e3", "type": "Gene/protein/RNA", "text": [ "cyclin D1" ], "offsets": [ [ 135, 144 ] ], "normalized": [] }, { "id": "BioInfer.d765.s0.e4", "type": "Gene/protein/RNA", "text": [ "cyclin A" ], "offsets": [ [ 114, 122 ] ], "normalized": [] }, { "id": "BioInfer.d765.s0.e5", "type": "Gene/protein/RNA", "text": [ "cyclin B1" ], "offsets": [ [ 124, 133 ] ], "normalized": [] }, { "id": "BioInfer.d765.s0.e6", "type": "Individual_protein", "text": [ "p57" ], "offsets": [ [ 200, 203 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d765.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d765.s0.e0", "arg2_id": "BioInfer.d765.s0.e1", "normalized": [] }, { "id": "BioInfer.d765.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d765.s0.e0", "arg2_id": "BioInfer.d765.s0.e2", "normalized": [] }, { "id": "BioInfer.d765.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d765.s0.e1", "arg2_id": "BioInfer.d765.s0.e6", "normalized": [] }, { "id": "BioInfer.d765.s0.i3", "type": "PPI", "arg1_id": "BioInfer.d765.s0.e2", "arg2_id": "BioInfer.d765.s0.e6", "normalized": [] } ]

[ { "id": "BioInfer.d766.s0__text", "type": "Sentence", "text": [ "To determine the relative importance of protein degradation in the development of starvation-induced cardiac atrophy, in vivo fractional synthetic rates of total cardiac protein, myosin heavy chain, actin, light chain 1, and light chain 2 were measured in fed and fasted rabbits by continuous infusion of [3H] leucine." ], "offsets": [ [ 0, 318 ] ] } ]

[ { "id": "BioInfer.d766.s0.e0", "type": "Gene/protein/RNA", "text": [ "myosin", "light chain 2" ], "offsets": [ [ 179, 185 ], [ 225, 238 ] ], "normalized": [] }, { "id": "BioInfer.d766.s0.e1", "type": "Gene/protein/RNA", "text": [ "actin" ], "offsets": [ [ 199, 204 ] ], "normalized": [] }, { "id": "BioInfer.d766.s0.e2", "type": "Gene/protein/RNA", "text": [ "myosin", "light chain 1" ], "offsets": [ [ 179, 185 ], [ 206, 219 ] ], "normalized": [] }, { "id": "BioInfer.d766.s0.e3", "type": "Gene/protein/RNA", "text": [ "myosin heavy chain" ], "offsets": [ [ 179, 197 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d767.s0__text", "type": "Sentence", "text": [ "To determine whether alpha 1-adrenergic stimulation produced similar effects on the turnover of myofibrillar proteins, rates of synthesis and degradation were estimated for a myofibrillar-enriched protein fraction and for myosin heavy chain and actin." ], "offsets": [ [ 0, 251 ] ] } ]

[ { "id": "BioInfer.d767.s0.e0", "type": "Gene/protein/RNA", "text": [ "myosin heavy chain" ], "offsets": [ [ 222, 240 ] ], "normalized": [] }, { "id": "BioInfer.d767.s0.e1", "type": "Gene/protein/RNA", "text": [ "actin" ], "offsets": [ [ 245, 250 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d768.s0__text", "type": "Sentence", "text": [ "Together these results indicate that TGFbeta regulates clusterin gene expression through an AP-1 site and its cognate transcription factor AP-1, and requires the involvement of protein kinase C." ], "offsets": [ [ 0, 194 ] ] } ]

[ { "id": "BioInfer.d768.s0.e0", "type": "Individual_protein", "text": [ "TGFbeta" ], "offsets": [ [ 37, 44 ] ], "normalized": [] }, { "id": "BioInfer.d768.s0.e1", "type": "Individual_protein", "text": [ "clusterin" ], "offsets": [ [ 55, 64 ] ], "normalized": [] }, { "id": "BioInfer.d768.s0.e2", "type": "Individual_protein", "text": [ "AP-1" ], "offsets": [ [ 139, 143 ] ], "normalized": [] }, { "id": "BioInfer.d768.s0.e3", "type": "Individual_protein", "text": [ "AP-1" ], "offsets": [ [ 92, 96 ] ], "normalized": [] }, { "id": "BioInfer.d768.s0.e4", "type": "Individual_protein", "text": [ "protein kinase C" ], "offsets": [ [ 177, 193 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d768.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d768.s0.e0", "arg2_id": "BioInfer.d768.s0.e1", "normalized": [] }, { "id": "BioInfer.d768.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d768.s0.e0", "arg2_id": "BioInfer.d768.s0.e2", "normalized": [] }, { "id": "BioInfer.d768.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d768.s0.e0", "arg2_id": "BioInfer.d768.s0.e3", "normalized": [] }, { "id": "BioInfer.d768.s0.i3", "type": "PPI", "arg1_id": "BioInfer.d768.s0.e0", "arg2_id": "BioInfer.d768.s0.e4", "normalized": [] }, { "id": "BioInfer.d768.s0.i4", "type": "PPI", "arg1_id": "BioInfer.d768.s0.e1", "arg2_id": "BioInfer.d768.s0.e2", "normalized": [] }, { "id": "BioInfer.d768.s0.i5", "type": "PPI", "arg1_id": "BioInfer.d768.s0.e1", "arg2_id": "BioInfer.d768.s0.e3", "normalized": [] }, { "id": "BioInfer.d768.s0.i6", "type": "PPI", "arg1_id": "BioInfer.d768.s0.e2", "arg2_id": "BioInfer.d768.s0.e3", "normalized": [] } ]

[ { "id": "BioInfer.d769.s0__text", "type": "Sentence", "text": [ "To improve our ability to study these proteins, we have expressed UL5, UL8, UL9, and UL52 in insect cells by using the baculovirus expression system." ], "offsets": [ [ 0, 149 ] ] } ]

[ { "id": "BioInfer.d769.s0.e0", "type": "Gene/protein/RNA", "text": [ "UL5" ], "offsets": [ [ 66, 69 ] ], "normalized": [] }, { "id": "BioInfer.d769.s0.e1", "type": "Gene/protein/RNA", "text": [ "UL9" ], "offsets": [ [ 76, 79 ] ], "normalized": [] }, { "id": "BioInfer.d769.s0.e2", "type": "Gene/protein/RNA", "text": [ "UL8" ], "offsets": [ [ 71, 74 ] ], "normalized": [] }, { "id": "BioInfer.d769.s0.e3", "type": "Gene/protein/RNA", "text": [ "UL52" ], "offsets": [ [ 85, 89 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d769.s1__text", "type": "Sentence", "text": [ "Various immunological assays suggest that four of these proteins (UL5, UL8, UL9, and UL52) are made in infected cells in very low abundance relative to the other three." ], "offsets": [ [ 0, 168 ] ] } ]

[ { "id": "BioInfer.d769.s1.e0", "type": "Gene/protein/RNA", "text": [ "UL52" ], "offsets": [ [ 85, 89 ] ], "normalized": [] }, { "id": "BioInfer.d769.s1.e1", "type": "Gene/protein/RNA", "text": [ "UL8" ], "offsets": [ [ 71, 74 ] ], "normalized": [] }, { "id": "BioInfer.d769.s1.e2", "type": "Gene/protein/RNA", "text": [ "UL9" ], "offsets": [ [ 76, 79 ] ], "normalized": [] }, { "id": "BioInfer.d769.s1.e3", "type": "Gene/protein/RNA", "text": [ "UL5" ], "offsets": [ [ 66, 69 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d772.s0__text", "type": "Sentence", "text": [ "Transcriptional expression of TNFR1(p55), as well as that of FLICE, Fas, FADD, DR3, FAF, TRADD, and RIP was similar in these cell lines, indicating that the susceptibility to TNFalpha-induced apoptosis may not be determined by the constitutive expression level of these factors." ], "offsets": [ [ 0, 278 ] ] } ]

[ { "id": "BioInfer.d772.s0.e0", "type": "Individual_protein", "text": [ "FLICE" ], "offsets": [ [ 61, 66 ] ], "normalized": [] }, { "id": "BioInfer.d772.s0.e1", "type": "Individual_protein", "text": [ "TRADD" ], "offsets": [ [ 89, 94 ] ], "normalized": [] }, { "id": "BioInfer.d772.s0.e2", "type": "Individual_protein", "text": [ "FADD" ], "offsets": [ [ 73, 77 ] ], "normalized": [] }, { "id": "BioInfer.d772.s0.e3", "type": "Individual_protein", "text": [ "TNFalpha" ], "offsets": [ [ 175, 183 ] ], "normalized": [] }, { "id": "BioInfer.d772.s0.e4", "type": "Individual_protein", "text": [ "FAF" ], "offsets": [ [ 84, 87 ] ], "normalized": [] }, { "id": "BioInfer.d772.s0.e5", "type": "Individual_protein", "text": [ "TNFR1" ], "offsets": [ [ 30, 35 ] ], "normalized": [] }, { "id": "BioInfer.d772.s0.e6", "type": "Individual_protein", "text": [ "DR3" ], "offsets": [ [ 79, 82 ] ], "normalized": [] }, { "id": "BioInfer.d772.s0.e7", "type": "Individual_protein", "text": [ "Fas" ], "offsets": [ [ 68, 71 ] ], "normalized": [] }, { "id": "BioInfer.d772.s0.e8", "type": "Individual_protein", "text": [ "p55" ], "offsets": [ [ 36, 39 ] ], "normalized": [] }, { "id": "BioInfer.d772.s0.e9", "type": "Individual_protein", "text": [ "RIP" ], "offsets": [ [ 100, 103 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d772.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d772.s0.e0", "arg2_id": "BioInfer.d772.s0.e3", "normalized": [] }, { "id": "BioInfer.d772.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d772.s0.e1", "arg2_id": "BioInfer.d772.s0.e3", "normalized": [] }, { "id": "BioInfer.d772.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d772.s0.e2", "arg2_id": "BioInfer.d772.s0.e3", "normalized": [] }, { "id": "BioInfer.d772.s0.i3", "type": "PPI", "arg1_id": "BioInfer.d772.s0.e3", "arg2_id": "BioInfer.d772.s0.e4", "normalized": [] }, { "id": "BioInfer.d772.s0.i4", "type": "PPI", "arg1_id": "BioInfer.d772.s0.e3", "arg2_id": "BioInfer.d772.s0.e5", "normalized": [] }, { "id": "BioInfer.d772.s0.i5", "type": "PPI", "arg1_id": "BioInfer.d772.s0.e3", "arg2_id": "BioInfer.d772.s0.e6", "normalized": [] }, { "id": "BioInfer.d772.s0.i6", "type": "PPI", "arg1_id": "BioInfer.d772.s0.e3", "arg2_id": "BioInfer.d772.s0.e7", "normalized": [] }, { "id": "BioInfer.d772.s0.i7", "type": "PPI", "arg1_id": "BioInfer.d772.s0.e3", "arg2_id": "BioInfer.d772.s0.e8", "normalized": [] }, { "id": "BioInfer.d772.s0.i8", "type": "PPI", "arg1_id": "BioInfer.d772.s0.e3", "arg2_id": "BioInfer.d772.s0.e9", "normalized": [] } ]

[ { "id": "BioInfer.d773.s0__text", "type": "Sentence", "text": [ "Transcriptional regulation in the galactose regulon of yeast is determined by an interplay between a positive regulatory protein, GAL4, and a negative regulatory protein, GAL80." ], "offsets": [ [ 0, 177 ] ] } ]

[ { "id": "BioInfer.d773.s0.e0", "type": "Individual_protein", "text": [ "GAL4" ], "offsets": [ [ 130, 134 ] ], "normalized": [] }, { "id": "BioInfer.d773.s0.e1", "type": "Individual_protein", "text": [ "GAL80" ], "offsets": [ [ 171, 176 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d773.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d773.s0.e0", "arg2_id": "BioInfer.d773.s0.e1", "normalized": [] } ]

[ { "id": "BioInfer.d774.s0__text", "type": "Sentence", "text": [ "Transfection of alpha-catenin-deficient colon carcinoma cells recruited E-cadherin and beta-catenin to cell-cell contacts and functional cadherin-mediated cell-cell adhesion was restored in this way." ], "offsets": [ [ 0, 199 ] ] } ]

[ { "id": "BioInfer.d774.s0.e0", "type": "Gene/protein/RNA", "text": [ "beta-catenin" ], "offsets": [ [ 87, 99 ] ], "normalized": [] }, { "id": "BioInfer.d774.s0.e1", "type": "Gene/protein/RNA", "text": [ "alpha-catenin" ], "offsets": [ [ 16, 29 ] ], "normalized": [] }, { "id": "BioInfer.d774.s0.e2", "type": "Gene/protein/RNA", "text": [ "cadherin" ], "offsets": [ [ 137, 145 ] ], "normalized": [] }, { "id": "BioInfer.d774.s0.e3", "type": "Gene/protein/RNA", "text": [ "E-cadherin" ], "offsets": [ [ 72, 82 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d776.s0__text", "type": "Sentence", "text": [ "Treatment of cells with gamma linolenic acid (GLA) increased alpha catenin expression in most cell lines, while beta catenin levels were reduced, and gamma catenin expression was unchanged." ], "offsets": [ [ 0, 189 ] ] } ]

[ { "id": "BioInfer.d776.s0.e0", "type": "Gene/protein/RNA", "text": [ "beta catenin" ], "offsets": [ [ 112, 124 ] ], "normalized": [] }, { "id": "BioInfer.d776.s0.e1", "type": "Gene/protein/RNA", "text": [ "gamma catenin" ], "offsets": [ [ 150, 163 ] ], "normalized": [] }, { "id": "BioInfer.d776.s0.e2", "type": "Gene/protein/RNA", "text": [ "alpha catenin" ], "offsets": [ [ 61, 74 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d777.s0__text", "type": "Sentence", "text": [ "Treatment with HNE resulted in activation of extracellular signal-regulated protein kinases ERK1 and ERK2, induction of c-fos and c-jun protein expression, and an increase in transcription factor AP-1 DNA binding activity." ], "offsets": [ [ 0, 222 ] ] } ]

[ { "id": "BioInfer.d777.s0.e0", "type": "Individual_protein", "text": [ "ERK1" ], "offsets": [ [ 92, 96 ] ], "normalized": [] }, { "id": "BioInfer.d777.s0.e1", "type": "Individual_protein", "text": [ "ERK2" ], "offsets": [ [ 101, 105 ] ], "normalized": [] }, { "id": "BioInfer.d777.s0.e2", "type": "Gene/protein/RNA", "text": [ "AP-1" ], "offsets": [ [ 196, 200 ] ], "normalized": [] }, { "id": "BioInfer.d777.s0.e3", "type": "Gene/protein/RNA", "text": [ "c-jun" ], "offsets": [ [ 130, 135 ] ], "normalized": [] }, { "id": "BioInfer.d777.s0.e4", "type": "Gene/protein/RNA", "text": [ "c-fos" ], "offsets": [ [ 120, 125 ] ], "normalized": [] }, { "id": "BioInfer.d777.s0.e5", "type": "Protein_family_or_group", "text": [ "extracellular signal-regulated protein kinases" ], "offsets": [ [ 45, 91 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d777.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d777.s0.e0", "arg2_id": "BioInfer.d777.s0.e5", "normalized": [] }, { "id": "BioInfer.d777.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d777.s0.e1", "arg2_id": "BioInfer.d777.s0.e5", "normalized": [] } ]

[ { "id": "BioInfer.d779.s0__text", "type": "Sentence", "text": [ "Two cDNAs, isolated from a Xenopus laevis embryonic library, encode proteins of 168 amino acids, both of which are 77% identical to chick cofilin and 66% identical to chick actin-depolymerizing factor (ADF), two structurally and functionally related proteins." ], "offsets": [ [ 0, 259 ] ] } ]

[ { "id": "BioInfer.d779.s0.e0", "type": "Individual_protein", "text": [ "actin-depolymerizing factor" ], "offsets": [ [ 173, 200 ] ], "normalized": [] }, { "id": "BioInfer.d779.s0.e1", "type": "Individual_protein", "text": [ "ADF" ], "offsets": [ [ 202, 205 ] ], "normalized": [] }, { "id": "BioInfer.d779.s0.e2", "type": "Individual_protein", "text": [ "cofilin" ], "offsets": [ [ 138, 145 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d779.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d779.s0.e0", "arg2_id": "BioInfer.d779.s0.e2", "normalized": [] }, { "id": "BioInfer.d779.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d779.s0.e1", "arg2_id": "BioInfer.d779.s0.e2", "normalized": [] } ]

[ { "id": "BioInfer.d781.s0__text", "type": "Sentence", "text": [ "Under all conditions, platelets retained 40-50% of their total actin and greater than 70% of their actin-binding protein (ABP) but lost greater than 80% of talin and myosin to the supernatant." ], "offsets": [ [ 0, 192 ] ] } ]

[ { "id": "BioInfer.d781.s0.e0", "type": "Gene/protein/RNA", "text": [ "myosin" ], "offsets": [ [ 166, 172 ] ], "normalized": [] }, { "id": "BioInfer.d781.s0.e1", "type": "Individual_protein", "text": [ "ABP" ], "offsets": [ [ 122, 125 ] ], "normalized": [] }, { "id": "BioInfer.d781.s0.e2", "type": "Individual_protein", "text": [ "actin-binding protein" ], "offsets": [ [ 99, 120 ] ], "normalized": [] }, { "id": "BioInfer.d781.s0.e3", "type": "Gene/protein/RNA", "text": [ "talin" ], "offsets": [ [ 156, 161 ] ], "normalized": [] }, { "id": "BioInfer.d781.s0.e4", "type": "Gene/protein/RNA", "text": [ "actin" ], "offsets": [ [ 63, 68 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d782.s0__text", "type": "Sentence", "text": [ "Unexpectedly, treatment with the actin-depolymerizing drug latrunculin-A disrupted the medial region targeting pattern, and cells deficient in the actin-binding proteins tropomyosin and profilin also did not exhibit medial GFP-Cdc42p staining." ], "offsets": [ [ 0, 243 ] ] } ]

[ { "id": "BioInfer.d782.s0.e0", "type": "Individual_protein", "text": [ "profilin" ], "offsets": [ [ 186, 194 ] ], "normalized": [] }, { "id": "BioInfer.d782.s0.e1", "type": "Individual_protein", "text": [ "tropomyosin" ], "offsets": [ [ 170, 181 ] ], "normalized": [] }, { "id": "BioInfer.d782.s0.e2", "type": "Individual_protein", "text": [ "Cdc42p" ], "offsets": [ [ 227, 233 ] ], "normalized": [] }, { "id": "BioInfer.d782.s0.e3", "type": "Gene/protein/RNA", "text": [ "actin" ], "offsets": [ [ 33, 38 ] ], "normalized": [] }, { "id": "BioInfer.d782.s0.e4", "type": "Individual_protein", "text": [ "GFP" ], "offsets": [ [ 223, 226 ] ], "normalized": [] }, { "id": "BioInfer.d782.s0.e5", "type": "Protein_family_or_group", "text": [ "actin-binding proteins" ], "offsets": [ [ 147, 169 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d782.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d782.s0.e0", "arg2_id": "BioInfer.d782.s0.e5", "normalized": [] }, { "id": "BioInfer.d782.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d782.s0.e1", "arg2_id": "BioInfer.d782.s0.e5", "normalized": [] }, { "id": "BioInfer.d782.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d782.s0.e2", "arg2_id": "BioInfer.d782.s0.e4", "normalized": [] } ]

[ { "id": "BioInfer.d783.s0__text", "type": "Sentence", "text": [ "Unlike fimbrin, L-plastin's actin-bundling action was strictly calcium-dependent: the bundles were formed at pCa 7, but not at pCa 6." ], "offsets": [ [ 0, 133 ] ] } ]

[ { "id": "BioInfer.d783.s0.e0", "type": "Individual_protein", "text": [ "L-plastin" ], "offsets": [ [ 16, 25 ] ], "normalized": [] }, { "id": "BioInfer.d783.s0.e1", "type": "Individual_protein", "text": [ "fimbrin" ], "offsets": [ [ 7, 14 ] ], "normalized": [] }, { "id": "BioInfer.d783.s0.e2", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 28, 33 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d783.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d783.s0.e0", "arg2_id": "BioInfer.d783.s0.e2", "normalized": [] }, { "id": "BioInfer.d783.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d783.s0.e1", "arg2_id": "BioInfer.d783.s0.e2", "normalized": [] } ]

[ { "id": "BioInfer.d784.s0__text", "type": "Sentence", "text": [ "Unmasking of this site serves as a molecular switch that initiates assembly of an actin-based motility complex containing VASP and profilin." ], "offsets": [ [ 0, 140 ] ] } ]

[ { "id": "BioInfer.d784.s0.e0", "type": "Individual_protein", "text": [ "VASP" ], "offsets": [ [ 122, 126 ] ], "normalized": [] }, { "id": "BioInfer.d784.s0.e1", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 82, 87 ] ], "normalized": [] }, { "id": "BioInfer.d784.s0.e2", "type": "Individual_protein", "text": [ "profilin" ], "offsets": [ [ 131, 139 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d784.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d784.s0.e0", "arg2_id": "BioInfer.d784.s0.e1", "normalized": [] }, { "id": "BioInfer.d784.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d784.s0.e0", "arg2_id": "BioInfer.d784.s0.e2", "normalized": [] }, { "id": "BioInfer.d784.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d784.s0.e1", "arg2_id": "BioInfer.d784.s0.e2", "normalized": [] } ]

[ { "id": "BioInfer.d786.s0__text", "type": "Sentence", "text": [ "Using a complementary sequence or antipeptide to selectively neutralize the stretch of residues 633-642 of skeletal myosin heavy chain, we recently demonstrated that this segment is an actin binding site operating in the absence as in the presence of nucleotide and that this stretch 633-642 is not part of the nucleotide binding site [Chaussepied & Morales (1988) Proc. Natl. Acad. Sci. U.S.A. 85, 7471-7475]." ], "offsets": [ [ 0, 410 ] ] } ]

[ { "id": "BioInfer.d786.s0.e0", "type": "Individual_protein", "text": [ "skeletal myosin heavy chain" ], "offsets": [ [ 107, 134 ] ], "normalized": [] }, { "id": "BioInfer.d786.s0.e1", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 185, 190 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d786.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d786.s0.e0", "arg2_id": "BioInfer.d786.s0.e1", "normalized": [] } ]

[ { "id": "BioInfer.d787.s0__text", "type": "Sentence", "text": [ "Using ITP (a substrate for myosin II ATPase) and/or ATP gamma S (a substrate for myosin II heavy-chain kinase [MHCK]), we demonstrated that phosphorylation of myosin heavy chains occurred at the foci within the actin network, a result that suggests that MHCK was localized at the foci." ], "offsets": [ [ 0, 285 ] ] } ]

[ { "id": "BioInfer.d787.s0.e0", "type": "Individual_protein", "text": [ "MHCK" ], "offsets": [ [ 111, 115 ] ], "normalized": [] }, { "id": "BioInfer.d787.s0.e1", "type": "Protein_family_or_group", "text": [ "ATPase" ], "offsets": [ [ 37, 43 ] ], "normalized": [] }, { "id": "BioInfer.d787.s0.e2", "type": "Individual_protein", "text": [ "myosin II" ], "offsets": [ [ 27, 36 ] ], "normalized": [] }, { "id": "BioInfer.d787.s0.e3", "type": "Individual_protein", "text": [ "MHCK" ], "offsets": [ [ 254, 258 ] ], "normalized": [] }, { "id": "BioInfer.d787.s0.e4", "type": "Individual_protein", "text": [ "myosin II heavy-chain kinase" ], "offsets": [ [ 81, 109 ] ], "normalized": [] }, { "id": "BioInfer.d787.s0.e5", "type": "Individual_protein", "text": [ "myosin heavy chains" ], "offsets": [ [ 159, 178 ] ], "normalized": [] }, { "id": "BioInfer.d787.s0.e6", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 211, 216 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d787.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d787.s0.e1", "arg2_id": "BioInfer.d787.s0.e2", "normalized": [] } ]

[ { "id": "BioInfer.d788.s0__text", "type": "Sentence", "text": [ "Using the known three-dimensional structure of the homologous actin-binding domain of fimbrin, these results have enabled us to determine the likely orientation of the utrophin actin-binding domain with respect to the actin filament." ], "offsets": [ [ 0, 233 ] ] } ]

[ { "id": "BioInfer.d788.s0.e0", "type": "Individual_protein", "text": [ "utrophin" ], "offsets": [ [ 168, 176 ] ], "normalized": [] }, { "id": "BioInfer.d788.s0.e1", "type": "Individual_protein", "text": [ "fimbrin" ], "offsets": [ [ 86, 93 ] ], "normalized": [] }, { "id": "BioInfer.d788.s0.e2", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 218, 223 ] ], "normalized": [] }, { "id": "BioInfer.d788.s0.e3", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 177, 182 ] ], "normalized": [] }, { "id": "BioInfer.d788.s0.e4", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 62, 67 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d788.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d788.s0.e0", "arg2_id": "BioInfer.d788.s0.e1", "normalized": [] }, { "id": "BioInfer.d788.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d788.s0.e0", "arg2_id": "BioInfer.d788.s0.e2", "normalized": [] }, { "id": "BioInfer.d788.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d788.s0.e0", "arg2_id": "BioInfer.d788.s0.e3", "normalized": [] }, { "id": "BioInfer.d788.s0.i3", "type": "PPI", "arg1_id": "BioInfer.d788.s0.e1", "arg2_id": "BioInfer.d788.s0.e4", "normalized": [] } ]

[ { "id": "BioInfer.d789.s0__text", "type": "Sentence", "text": [ "Using the 'nuclear displacement assay' as a measure of the integrity of the actin cytoskeleton in living stamen hair cells, we demonstrated that AtFim1 protects actin filaments in these cells from Z. mays profilin (ZmPRO5)-induced depolymerization, in a dose-dependent manner." ], "offsets": [ [ 0, 276 ] ] } ]

[ { "id": "BioInfer.d789.s0.e0", "type": "Individual_protein", "text": [ "profilin" ], "offsets": [ [ 205, 213 ] ], "normalized": [] }, { "id": "BioInfer.d789.s0.e1", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 161, 166 ] ], "normalized": [] }, { "id": "BioInfer.d789.s0.e2", "type": "Individual_protein", "text": [ "AtFim1" ], "offsets": [ [ 145, 151 ] ], "normalized": [] }, { "id": "BioInfer.d789.s0.e3", "type": "Individual_protein", "text": [ "ZmPRO5" ], "offsets": [ [ 215, 221 ] ], "normalized": [] }, { "id": "BioInfer.d789.s0.e4", "type": "Gene/protein/RNA", "text": [ "actin" ], "offsets": [ [ 76, 81 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d789.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d789.s0.e0", "arg2_id": "BioInfer.d789.s0.e1", "normalized": [] }, { "id": "BioInfer.d789.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d789.s0.e1", "arg2_id": "BioInfer.d789.s0.e2", "normalized": [] }, { "id": "BioInfer.d789.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d789.s0.e1", "arg2_id": "BioInfer.d789.s0.e3", "normalized": [] } ]

[ { "id": "BioInfer.d790.s0__text", "type": "Sentence", "text": [ "Using these methods, we confirm previous reports that intact talin induces cross-linking as well as filament shortening on actin networks." ], "offsets": [ [ 0, 138 ] ] } ]

[ { "id": "BioInfer.d790.s0.e0", "type": "Individual_protein", "text": [ "talin" ], "offsets": [ [ 61, 66 ] ], "normalized": [] }, { "id": "BioInfer.d790.s0.e1", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 123, 128 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d790.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d790.s0.e0", "arg2_id": "BioInfer.d790.s0.e1", "normalized": [] } ]

[ { "id": "BioInfer.d791.s0__text", "type": "Sentence", "text": [ "Vascular endothelial cadherin (VE-cadherin) clusters were co-localized with beta-catenin, an important signal transduction ligand, and with alpha-catenin, which is thought to link the complex to the peri-junctional actin." ], "offsets": [ [ 0, 221 ] ] } ]

[ { "id": "BioInfer.d791.s0.e0", "type": "Individual_protein", "text": [ "VE-cadherin" ], "offsets": [ [ 31, 42 ] ], "normalized": [] }, { "id": "BioInfer.d791.s0.e1", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 215, 220 ] ], "normalized": [] }, { "id": "BioInfer.d791.s0.e2", "type": "Individual_protein", "text": [ "Vascular endothelial cadherin" ], "offsets": [ [ 0, 29 ] ], "normalized": [] }, { "id": "BioInfer.d791.s0.e3", "type": "Individual_protein", "text": [ "alpha-catenin" ], "offsets": [ [ 140, 153 ] ], "normalized": [] }, { "id": "BioInfer.d791.s0.e4", "type": "Individual_protein", "text": [ "beta-catenin" ], "offsets": [ [ 76, 88 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d791.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d791.s0.e0", "arg2_id": "BioInfer.d791.s0.e3", "normalized": [] }, { "id": "BioInfer.d791.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d791.s0.e0", "arg2_id": "BioInfer.d791.s0.e4", "normalized": [] }, { "id": "BioInfer.d791.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d791.s0.e1", "arg2_id": "BioInfer.d791.s0.e3", "normalized": [] }, { "id": "BioInfer.d791.s0.i3", "type": "PPI", "arg1_id": "BioInfer.d791.s0.e2", "arg2_id": "BioInfer.d791.s0.e3", "normalized": [] }, { "id": "BioInfer.d791.s0.i4", "type": "PPI", "arg1_id": "BioInfer.d791.s0.e2", "arg2_id": "BioInfer.d791.s0.e4", "normalized": [] } ]

[ { "id": "BioInfer.d792.s0__text", "type": "Sentence", "text": [ "VASP, in turn, provides the ABM-2 sequences [XPPPPP, X = G, P, L, S, A] for binding profilin, an actin-regulatory protein that stimulates actin filament assembly." ], "offsets": [ [ 0, 162 ] ] } ]

[ { "id": "BioInfer.d792.s0.e0", "type": "Individual_protein", "text": [ "profilin" ], "offsets": [ [ 84, 92 ] ], "normalized": [] }, { "id": "BioInfer.d792.s0.e1", "type": "Individual_protein", "text": [ "VASP" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "BioInfer.d792.s0.e2", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 97, 102 ] ], "normalized": [] }, { "id": "BioInfer.d792.s0.e3", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 138, 143 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d792.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d792.s0.e0", "arg2_id": "BioInfer.d792.s0.e1", "normalized": [] }, { "id": "BioInfer.d792.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d792.s0.e0", "arg2_id": "BioInfer.d792.s0.e2", "normalized": [] }, { "id": "BioInfer.d792.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d792.s0.e0", "arg2_id": "BioInfer.d792.s0.e3", "normalized": [] } ]

[ { "id": "BioInfer.d793.s0__text", "type": "Sentence", "text": [ "Villin and fimbrin are two actin-binding proteins that bundle actin filaments in the intestine and kidney brush border epithelium." ], "offsets": [ [ 0, 130 ] ] } ]

[ { "id": "BioInfer.d793.s0.e0", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 62, 67 ] ], "normalized": [] }, { "id": "BioInfer.d793.s0.e1", "type": "Individual_protein", "text": [ "fimbrin" ], "offsets": [ [ 11, 18 ] ], "normalized": [] }, { "id": "BioInfer.d793.s0.e2", "type": "Individual_protein", "text": [ "Villin" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "BioInfer.d793.s0.e3", "type": "Protein_family_or_group", "text": [ "actin-binding proteins" ], "offsets": [ [ 27, 49 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d793.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d793.s0.e0", "arg2_id": "BioInfer.d793.s0.e1", "normalized": [] }, { "id": "BioInfer.d793.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d793.s0.e0", "arg2_id": "BioInfer.d793.s0.e2", "normalized": [] }, { "id": "BioInfer.d793.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d793.s0.e1", "arg2_id": "BioInfer.d793.s0.e3", "normalized": [] }, { "id": "BioInfer.d793.s0.i3", "type": "PPI", "arg1_id": "BioInfer.d793.s0.e2", "arg2_id": "BioInfer.d793.s0.e3", "normalized": [] } ]

[ { "id": "BioInfer.d795.s0__text", "type": "Sentence", "text": [ "WASp contains a binding motif for the Rho GTPase CDC42Hs as well as verprolin/cofilin-like actin-regulatory domains, but no specific actin structure regulated by CDC42Hs-WASp has been identified." ], "offsets": [ [ 0, 195 ] ] } ]

[ { "id": "BioInfer.d795.s0.e0", "type": "Individual_protein", "text": [ "verprolin" ], "offsets": [ [ 68, 77 ] ], "normalized": [] }, { "id": "BioInfer.d795.s0.e1", "type": "Individual_protein", "text": [ "cofilin" ], "offsets": [ [ 78, 85 ] ], "normalized": [] }, { "id": "BioInfer.d795.s0.e2", "type": "Individual_protein", "text": [ "CDC42Hs" ], "offsets": [ [ 49, 56 ] ], "normalized": [] }, { "id": "BioInfer.d795.s0.e3", "type": "Individual_protein", "text": [ "WASp" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "BioInfer.d795.s0.e4", "type": "Individual_protein", "text": [ "CDC42Hs" ], "offsets": [ [ 162, 169 ] ], "normalized": [] }, { "id": "BioInfer.d795.s0.e5", "type": "Individual_protein", "text": [ "WASp" ], "offsets": [ [ 170, 174 ] ], "normalized": [] }, { "id": "BioInfer.d795.s0.e6", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 91, 96 ] ], "normalized": [] }, { "id": "BioInfer.d795.s0.e7", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 133, 138 ] ], "normalized": [] }, { "id": "BioInfer.d795.s0.e8", "type": "Protein_family_or_group", "text": [ "Rho GTPase" ], "offsets": [ [ 38, 48 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d795.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d795.s0.e0", "arg2_id": "BioInfer.d795.s0.e3", "normalized": [] }, { "id": "BioInfer.d795.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d795.s0.e1", "arg2_id": "BioInfer.d795.s0.e3", "normalized": [] }, { "id": "BioInfer.d795.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d795.s0.e2", "arg2_id": "BioInfer.d795.s0.e3", "normalized": [] }, { "id": "BioInfer.d795.s0.i3", "type": "PPI", "arg1_id": "BioInfer.d795.s0.e2", "arg2_id": "BioInfer.d795.s0.e8", "normalized": [] }, { "id": "BioInfer.d795.s0.i4", "type": "PPI", "arg1_id": "BioInfer.d795.s0.e3", "arg2_id": "BioInfer.d795.s0.e6", "normalized": [] }, { "id": "BioInfer.d795.s0.i5", "type": "PPI", "arg1_id": "BioInfer.d795.s0.e4", "arg2_id": "BioInfer.d795.s0.e5", "normalized": [] }, { "id": "BioInfer.d795.s0.i6", "type": "PPI", "arg1_id": "BioInfer.d795.s0.e4", "arg2_id": "BioInfer.d795.s0.e7", "normalized": [] }, { "id": "BioInfer.d795.s0.i7", "type": "PPI", "arg1_id": "BioInfer.d795.s0.e5", "arg2_id": "BioInfer.d795.s0.e7", "normalized": [] } ]

[ { "id": "BioInfer.d796.s0__text", "type": "Sentence", "text": [ "We also analysed NHEJ in other DNA damage response mutants and showed that the checkpoint mutant rad3-d and two recombination mutants defective in rhp51 and rhp54 (homologues of S.cerevisiae RAD51 and RAD54, respectively) are not affected." ], "offsets": [ [ 0, 239 ] ] } ]

[ { "id": "BioInfer.d796.s0.e0", "type": "Gene", "text": [ "RAD51" ], "offsets": [ [ 191, 196 ] ], "normalized": [] }, { "id": "BioInfer.d796.s0.e1", "type": "Gene", "text": [ "RAD54" ], "offsets": [ [ 201, 206 ] ], "normalized": [] }, { "id": "BioInfer.d796.s0.e2", "type": "Gene", "text": [ "rhp51" ], "offsets": [ [ 147, 152 ] ], "normalized": [] }, { "id": "BioInfer.d796.s0.e3", "type": "Gene", "text": [ "rhp54" ], "offsets": [ [ 157, 162 ] ], "normalized": [] }, { "id": "BioInfer.d796.s0.e4", "type": "Gene/protein/RNA", "text": [ "rad3" ], "offsets": [ [ 97, 101 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d796.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d796.s0.e0", "arg2_id": "BioInfer.d796.s0.e2", "normalized": [] }, { "id": "BioInfer.d796.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d796.s0.e1", "arg2_id": "BioInfer.d796.s0.e3", "normalized": [] } ]

[ { "id": "BioInfer.d797.s0__text", "type": "Sentence", "text": [ "We believe that this complex may mediate the cortical functions of profilin at actin patches in S. pombe." ], "offsets": [ [ 0, 105 ] ] } ]

[ { "id": "BioInfer.d797.s0.e0", "type": "Individual_protein", "text": [ "profilin" ], "offsets": [ [ 67, 75 ] ], "normalized": [] }, { "id": "BioInfer.d797.s0.e1", "type": "Individual_protein", "text": [ "actin" ], "offsets": [ [ 79, 84 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d797.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d797.s0.e0", "arg2_id": "BioInfer.d797.s0.e1", "normalized": [] } ]

[ { "id": "BioInfer.d799.s0__text", "type": "Sentence", "text": [ "We constructed recombinant viruses based on the herpes simplex virus type 1 mutant tsK which individually were able to express the products of four viral DNA replication genes (UL5, UL8, UL9 and UL52) in the absence of any of the other proteins required for viral DNA synthesis." ], "offsets": [ [ 0, 278 ] ] } ]

[ { "id": "BioInfer.d799.s0.e0", "type": "Gene/protein/RNA", "text": [ "UL5" ], "offsets": [ [ 177, 180 ] ], "normalized": [] }, { "id": "BioInfer.d799.s0.e1", "type": "Gene/protein/RNA", "text": [ "UL9" ], "offsets": [ [ 187, 190 ] ], "normalized": [] }, { "id": "BioInfer.d799.s0.e2", "type": "Gene/protein/RNA", "text": [ "UL8" ], "offsets": [ [ 182, 185 ] ], "normalized": [] }, { "id": "BioInfer.d799.s0.e3", "type": "Gene/protein/RNA", "text": [ "UL52" ], "offsets": [ [ 195, 199 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "BioInfer.d800.s0__text", "type": "Sentence", "text": [ "We describe the localization of cadherin-11 and N-cadherin along the cell margins of mouse osteoblast-like cells, the colocalization of \"pancadherin\" with alpha-catenin, beta-catenin, p120, and vinculin, and the association of these complexes with the actin microfilaments." ], "offsets": [ [ 0, 273 ] ] } ]

[ { "id": "BioInfer.d800.s0.e0", "type": "Gene/protein/RNA", "text": [ "actin" ], "offsets": [ [ 252, 257 ] ], "normalized": [] }, { "id": "BioInfer.d800.s0.e1", "type": "Individual_protein", "text": [ "pancadherin" ], "offsets": [ [ 137, 148 ] ], "normalized": [] }, { "id": "BioInfer.d800.s0.e2", "type": "Individual_protein", "text": [ "p120" ], "offsets": [ [ 184, 188 ] ], "normalized": [] }, { "id": "BioInfer.d800.s0.e3", "type": "Individual_protein", "text": [ "alpha-catenin" ], "offsets": [ [ 155, 168 ] ], "normalized": [] }, { "id": "BioInfer.d800.s0.e4", "type": "Individual_protein", "text": [ "vinculin" ], "offsets": [ [ 194, 202 ] ], "normalized": [] }, { "id": "BioInfer.d800.s0.e5", "type": "Gene/protein/RNA", "text": [ "N-cadherin" ], "offsets": [ [ 48, 58 ] ], "normalized": [] }, { "id": "BioInfer.d800.s0.e6", "type": "Individual_protein", "text": [ "beta-catenin" ], "offsets": [ [ 170, 182 ] ], "normalized": [] }, { "id": "BioInfer.d800.s0.e7", "type": "Gene/protein/RNA", "text": [ "cadherin-11" ], "offsets": [ [ 32, 43 ] ], "normalized": [] } ]

[]

[]

[ { "id": "BioInfer.d800.s0.i0", "type": "PPI", "arg1_id": "BioInfer.d800.s0.e1", "arg2_id": "BioInfer.d800.s0.e2", "normalized": [] }, { "id": "BioInfer.d800.s0.i1", "type": "PPI", "arg1_id": "BioInfer.d800.s0.e1", "arg2_id": "BioInfer.d800.s0.e3", "normalized": [] }, { "id": "BioInfer.d800.s0.i2", "type": "PPI", "arg1_id": "BioInfer.d800.s0.e1", "arg2_id": "BioInfer.d800.s0.e4", "normalized": [] }, { "id": "BioInfer.d800.s0.i3", "type": "PPI", "arg1_id": "BioInfer.d800.s0.e1", "arg2_id": "BioInfer.d800.s0.e6", "normalized": [] } ]