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embedding_all-mpnet-base-v2
sequence
embedding_multi-qa-mpnet-base-dot-v1
sequence
embedding_all-MiniLM-L12-v2
sequence
25001475
2methods
Primary outcome was @-day mortality .
4
100
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25001475
2methods
Secondary outcomes were intensive care unit ( ICU ) and @-day mortality , severity of circulatory shock assessed by mean arterial pressure , serum lactate , fluid balance and the extended Sequential Organ Failure assessment ( SOFA ) score .
5
101
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25001475
4results
There was no significance difference between targeted temperature management at @ C or @ C on @-day mortality -LSB- log-rank test , p = @ , hazard ratio @ , @ % confidence interval ( CI ) @-@ @ -RSB- or ICU mortality ( @ vs. @ % , p = @ ; relative risk @ , @ % CI @-@ @ ) .
6
102
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25001475
4results
Serum lactate and the extended cardiovascular SOFA score were higher in the TTM@ group ( p < @ ) .
7
103
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25001475
1conclusions
We found no benefit in survival or severity of circulatory shock with targeted temperature management at @ C as compared to @ C in patients with shock on admission after OHCA .
8
104
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25406902
0background
Youths with a family history of alcohol and other drug use disorders ( FH + ) are at a greater risk of developing substance use disorders than their peers with no such family histories ( FH - ) , and this increased risk may be related to impaired maturation of forebrain circuitry .
0
105
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25406902
0background
FH + individuals have shown altered forebrain activity at rest and while performing cognitive tasks .
1
106
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25406902
0background
However , it is not fully understood how forebrain activity is altered in FH + individuals , and ultimately how these alterations may contribute to substance use disorder risk .
2
107
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25406902
2methods
In this study , we tested @ FH + and @ FH - youths performing a go/no-go task and examined activations in blocks with only go trials ( Go Only ) , blocks with @ % go and @ % no-go trials ( Go/NoGo ) , and a contrast of those @ blocks .
3
108
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25406902
4results
FH + youths had significantly greater cerebral activations in both the Go and Go/NoGo blocks than FH - youths in regions including the posterior cingulate/precuneus , bilateral middle/superior temporal gyrus , and medial superior frontal gyrus with no significant group differences in the subtraction between Go Only and Go/NoGo blocks .
4
109
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25406902
4results
Additionally , FH + youths had moderately slower reaction times on go trials in the Go Only blocks .
5
110
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25406902
1conclusions
Our findings suggest that global activation increase in FH + youths are modulated by FH density and are not specific to the inhibitory components of the task .
6
111
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25406902
1conclusions
This pattern of increased activations in FH + youths may be at least partially due to impaired forebrain white matter development leading to greater activations/less efficient neural communication during task performance .
7
112
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25471989
0background
Risk factors have been proposed for running injuries including ( a ) reduced muscular strength , ( b ) excessive joint movements and ( c ) excessive joint moments in the frontal and transverse planes .
0
113
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25471989
0background
To date , many running injury prevention programs have focused on a `` top down '' approach to strengthen the hip musculature in the attempt to reduce movements and moments at the hip , knee , and/or ankle joints .
1
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25471989
0background
However , running mechanics did not change when hip muscle strength increased .
2
115
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25471989
0background
It could be speculated that emphasis should be placed on increasing the strength of the ankle joint for a `` ground up '' approach .
3
116
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25471989
0background
Strengthening of the large and small muscles crossing the ankle joint is assumed to change the force distribution for these muscles and to increase the use of smaller muscles .
4
117
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25471989
0background
This would be associated with a reduction of joint and insertion forces , which could have a beneficial effect on injury prevention .
5
118
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25471989
0background
However , training of the ankle joint as an injury prevention strategy has not been studied .
6
119
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25471989
0background
Ankle strengthening techniques include isolated strengthening or movement-related strengthening such as functional balance training .
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120
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25471989
0background
There is little knowledge about the efficacy of such training programs on strength alteration , gait or injury reduction .
8
121
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25471989
2methods
Novice runners will be randomly assigned to one of three groups : an isolated ankle strengthening group ( strength , n = @ ) , a functional balance training group ( balance , n = @ ) or an activity-matched control group ( control , n = @ ) .
9
122
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25471989
2methods
Isokinetic strength will be measured using a Biodex System @ dynamometer .
10
123
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25471989
2methods
Running kinematics and kinetics will be assessed using @D motion analysis and a force platform .
11
124
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25471989
2methods
Postural control will be assessed by quantifying the magnitude and temporal structure of the center of pressure trace during single leg stance on a force platform .
12
125
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25471989
2methods
The change pre - and post-training in isokinetic strength , running mechanics , and postural control variables will be compared following the interventions .
13
126
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25471989
2methods
Injuries rates will be compared between groups over @months .
14
127
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25471989
1conclusions
Avoiding injury will allow individuals to enjoy the benefits of participating in aerobic activities and reduce the healthcare costs associated with running injuries .
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128
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24694205
0background
Vitamin B@ deficiency causes neurologic and psychiatric disease , especially in older adults .
0
129
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24694205
0background
Subacute combined degeneration is characterized by damage to the posterior and lateral spinal cord affecting the corticospinal tract .
1
130
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24694205
3objective
To test corticospinal tract projections using motor evoked potentials ( MEPs ) by transcranial magnetic stimulation ( TMS ) in asymptomatic older adults with low vitamin B@ ( B@ ) levels .
2
131
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24694205
2methods
Cross-sectional study of @ healthy older adults ( > @ years ) .
3
132
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24694205
2methods
MEPs were recorded in the abductor pollicis brevis and tibialis anterior muscles , at rest and during slight tonic contraction .
4
133
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24694205
2methods
Central motor conduction time ( CMCT ) was derived from the latency of MEPs and peripheral motor conduction time ( PMCT ) .
5
134
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24694205
2methods
Neurophysiological variables were analyzed statistically according to B@ status .
6
135
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24694205
4results
Median age was @ years ( @ % women ) .
7
136
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24694205
4results
Twenty-six out of the @ subjects had low vitamin B@ levels ( B@ < @pmol/l ) .
8
137
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24694205
4results
MEPs were recorded for all subjects in upper and lower extremities .
9
138
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24694205
4results
There were no significant differences in either latency or amplitude of MEPs and CMCT between low and normal B@ groups .
10
139
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24694205
4results
There was a significant PMCT delay in the lower extremities in the low B@ group ( p = @ ) .
11
140
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24694205
1conclusions
No subclinical abnormality of the corticospinal tract is detected in asymptomatic B@-deficient older adults .
12
141
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24694205
1conclusions
The peripheral nervous system appears to be more vulnerable to damage attributable to this vitamin deficit .
13
142
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24694205
1conclusions
The neurophysiological evaluation of asymptomatic older adults with lower B@ levels should be focused mainly in peripheral nervous system evaluation .
14
143
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24576512
0background
Uncontrolled hypertension ( HTN ) is a significant public health problem among blacks in the United States .
0
144
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24576512
0background
Despite the proven efficacy of therapeutic lifestyle change ( TLC ) on blood pressure ( BP ) reduction in clinical trials , few studies have examined their effectiveness in church-based settings-an influential institution for health promotion in black communities .
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24576512
2methods
Using a cluster-randomized , @-arm trial design , this study evaluates the effectiveness of a faith-based TLC intervention vs health education ( HE ) control on BP reduction among hypertensive black adults .
2
146
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24576512
2methods
The intervention is delivered by trained lay health advisors through group TLC sessions plus motivational interviewing in @ black churches .
3
147
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24576512
2methods
Participants in the intervention group receive @ weekly TLC sessions targeting weight loss , increasing physical activity , fruit , vegetable and low-fat dairy intake , and decreasing fat and sodium intake , plus @ monthly individual motivational interviewing sessions .
4
148
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24576512
2methods
Participants in the control group attend @ weekly classes on HTN and other health topics delivered by health care experts .
5
149
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24576512
2methods
The primary outcome is change in BP from baseline to @ months .
6
150
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24576512
2methods
Secondary outcomes include level of physical activity , percent change in weight , and fruit and vegetable consumption at @ months , and BP control at @ months .
7
151
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24576512
1conclusions
If successful , this trial will provide an alternative and culturally appropriate model for HTN control through evidence-based lifestyle modification delivered in churches by lay health advisors .
8
152
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24807407
0background
The classification of clinical severity of Ebstein anomaly still remains a challenge .
0
153
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24807407
0background
The aim of this study was to focus on the interaction of the pathologically altered right heart with the anatomically-supposedly-normal left heart and to derive from cardiac magnetic resonance ( CMR ) a simple imaging measure for the clinical severity of Ebstein anomaly .
1
154
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24807407
4results
Twenty-five patients at a mean age of @ years with unrepaired Ebstein anomaly were examined in a prospective study .
2
155
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24807407
4results
Disease severity was classified using CMR volumes and functional measurements in comparison with heart failure markers from clinical data , ECG , laboratory and cardiopulmonary exercise testing , and echocardiography .
3
156
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24807407
4results
All examinations were completed within @ hours .
4
157
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24807407
4results
A total right/left-volume index was defined from end-diastolic volume measurements in CMR : total right/left-volume index = ( RA + aRV + fRV ) / ( LA+LV ) .
5
158
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24807407
4results
Mean total right/left-volume index was @ ( normal values : @ ) .
6
159
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24807407
4results
This new total right/left-volume index correlated with almost all clinically used biomarkers of heart failure : brain natriuretic peptide ( r = @ ; P = @ ) , QRS ( r = @ ; P = @ ) , peak oxygen consumption/kg ( r = -@ ; P = @ ) , ventilatory response to carbon dioxide production at anaerobic threshold ( r = @ ; P = @ ) , the severity of tricuspid regurgitation ( r = @ ; P = @ ) , tricuspid valve offset ( r = @ ; P = @ ) , and tricuspid annular plane systolic excursion ( r = @ ; P = @ ) .
7
160
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24807407
4results
Previously described severity indices ( -LSB- RA + aRV -RSB- / -LSB- fRV + LA+LV -RSB- ) and fRV/LV end-diastolic volume corresponded only to some parameters .
8
161
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24807407
1conclusions
In patients with Ebstein anomaly , the easily acquired index of right-sided to left-sided heart volumes from CMR correlated well with established heart failure markers .
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162
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24807407
1conclusions
Our data suggest that the total right/left-volume index should be used as a new and simplified CMR measure , allowing more accurate assessment of disease severity than previously described scoring systems .
10
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24947717
3objective
This study sought to investigate the association of beta-blocker therapy at discharge with clinical outcomes in patients with ST-segment elevation myocardial infarction ( STEMI ) after primary percutaneous coronary intervention ( PCI ) .
0
164
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24947717
0background
Limited data are available on the efficacy of beta-blocker therapy for secondary prevention in STEMI patients .
1
165
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24947717
2methods
Between November @ , @ and September @ , @ , @,@ patients were enrolled in nationwide , prospective , multicenter registries .
2
166
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24947717
2methods
Among these , we studied STEMI patients undergoing primary PCI who were discharged alive ( n = @,@ ) .
3
167
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24947717
2methods
We classified patients into the beta-blocker group ( n = @,@ ) and no-beta-blocker group ( n = @,@ ) according to the use of beta-blockers at discharge .
4
168
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24947717
2methods
Propensity-score matching analysis was also performed in @,@ patient triplets .
5
169
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24947717
2methods
The primary outcome was all-cause death .
6
170
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24947717
4results
The median follow-up duration was @ days ( interquartile range : @ to @ days ) .
7
171
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24947717
4results
All-cause death occurred in @ patients ( @ % ) of the beta-blocker group versus @ patients ( @ % ) of the no-beta-blocker group ( p < @ ) .
8
172
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24947717
4results
After @:@ propensity-score matching , beta-blocker therapy was associated with a lower incidence of all-cause death ( @ % vs. @ % , adjusted hazard ratio : @ , @ % confidence interval : @ to @ , p = @ ) .
9
173
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24947717
4results
The association with better outcome of beta-blocker therapy in terms of all-cause death was consistent across various subgroups , including patients with relatively low-risk profiles such as ejection fraction > @ % or single-vessel disease .
10
174
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24947717
1conclusions
Beta-blocker therapy at discharge was associated with improved survival in STEMI patients treated with primary PCI .
11
175
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24947717
1conclusions
Our results support the current American College of Cardiology/American Heart Association guidelines , which recommend long-term beta-blocker therapy in all patients with STEMI regardless of reperfusion therapy or risk profile .
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24281275
3objective
Local anesthetic wound infiltration is widely used as an effective adjunct during multimodal postoperative pain management .
0
177
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24281275
3objective
The aim of this study was to evaluate the effectiveness of continuous wound infusion of ropivacaine in postoperative pain relief , opioid sparing , incidence of nausea and vomiting , and bowel and liver function improvement in patients undergoing open hepatectomy .
1
178
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24281275
2methods
Forty patients undergoing open hepatectomy were enrolled in this prospective , randomized , double-blinded , placebo-controlled trial .
2
179
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24281275
2methods
Patients were divided into @ groups : the @ % saline continuous infusion group ( the control group ; n = @ ) and the ropivacaine continuous infusion group ( the Ropi group ; n = @ ) .
3
180
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24281275
2methods
Outcomes measured postoperatively were pain score at rest and on movement , sufentanil consumption , incidence of nausea and vomiting , and sedation score across @ postoperative hours .
4
181
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24281275
2methods
Time to bowel recovery , liver function change , mean length of hospitalization , patient satisfaction , and other data after @ postoperative hours were collected until hospital discharge .
5
182
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24281275
4results
Pain scores at rest were lower for the ropivacaine group and reached significance after @ and @ hours ( P < @ ) .
6
183
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24281275
4results
Sufentanil consumption ( @ vs. @ g ; P < @ ) after @ hours , time to bowel recovery ( @ vs. @ d ; P < @ ) , incidence of nausea and vomiting ( @ vs. @ ; P < @ ) , and mean length of hospitalization ( @ vs. @ d ; P < @ ) were significantly reduced , and the sedation score and liver function change were also comparable between the @ groups .
7
184
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24281275
4results
There was no difference with respect to pain scores on movement , nor with respect to patient satisfaction .
8
185
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24281275
1conclusions
Surgical wound infusion with ropivacaine after hepatectomy can improve pain relief at rest and accelerate recovery and discharge .
9
186
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24911353
3objective
Tuberculosis ( TB ) is highly prevalent among HIV-infected people , including those receiving combination antiretroviral therapy ( cART ) , necessitating a well tolerated and efficacious TB vaccine for these populations .
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187
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24911353
3objective
We evaluated the safety and immunogenicity of the candidate TB vaccine M@/AS@ in adults with well controlled HIV infection on cART .
1
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24911353
2methods
A randomized , observer-blind , controlled trial ( NCT@ ) .
2
189
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24911353
2methods
HIV-infected adults on cART in Switzerland were randomized @:@:@ to receive two doses , @ month apart , of M@/AS@ , AS@ or @ % physiological saline ( N = @ , N = @ and N = @ , respectively ) and were followed up to @ months postdose @ ( D@ ) .
3
190
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24911353
2methods
Individuals with CD@ cell counts below @ cells/l were excluded .
4
191
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24911353
2methods
Adverse events ( AEs ) including HIV-specific and laboratory safety parameters were recorded .
5
192
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24911353
2methods
Cell-mediated ( ICS ) and humoral ( ELISA ) responses were evaluated before vaccination , @ month after each dose ( D@ , D@ ) and D@ .
6
193
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24911353
4results
Thirty-seven individuals -LSB- interquartile range ( IQR ) CD@ cell counts at screening : @-@ cells/l ; undetectable HIV-@ viremia -RSB- were enrolled ; @ % of individuals reported previous BCG vaccination , @ % tested negative for the QuantiFERON-TB assay .
7
194
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24911353
4results
For M@/AS@ recipients , no vaccine-related serious AEs or cART-regimen adjustments were recorded , and there were no clinically relevant effects on laboratory safety parameters , HIV-@ viral loads or CD@ cell counts .
8
195
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24911353
4results
M@/AS@ was immunogenic , inducing persistent and polyfunctional M@-specific CD@ T-cell responses -LSB- medians @ % ( IQR @-@ @ ) at D@ -RSB- and @ % ( @-@ @ ) at D@ , predominantly CD@LIL-@TNF - , CD@LIL-@ and CD@LIL-@TNF-IFN - -RSB- .
9
196
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24911353
4results
All M@/AS@ vaccines were seropositive for anti-M@ IgG after second vaccination until study end .
10
197
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24911353
1conclusions
M@/AS@ was clinically well tolerated and immunogenic in this population , supporting further clinical evaluation in HIV-infected individuals in TB-endemic settings .
11
198
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25318787
3objective
The aim of this study was to investigate whether remedial hydration ( RH ) reduces the incidence of contrast-induced nephropathy ( CIN ) and short-term adverse events in ST-elevation myocardial infarction ( STEMI ) patients undergoing primary percutaneous coronary intervention ( PCI ) .
0
199
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