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The estimation of material properties is important for scene understanding, with many applications in vision, robotics, and structural engineering. This paper connects fundamentals of vibration mechanics with computer vision techniques in order to infer material properties from small, often imperceptible motions in video. Objects tend to vibrate in a set of preferred modes. The frequencies of these modes depend on the structure and material properties of an object. We show that by extracting these frequencies from video of a vibrating object, we can often make inferences about that object's material properties. We demonstrate our approach by estimating material properties for a variety of objects by observing their motion in high-speed and regular frame rate video.

Diabetes disrupts the operation of the eye and leads to vision loss, affecting particularly the nerve layer and capillary vessels in this layer by changes in the blood vessels of the retina. Suddenly loss and blurred vision problems occur in the image, depending on the phase of the disease, called diabetic retinopathy. Hard exudates are one of the primary signs of diabetic retinopathy. Automatic recognition of hard exudates in retinal images can contribute to detection of the disease. We present an automatic screening system for the detection of hard exudates. This system consists of two main steps. Firstly, the features were extracted from patch images consisting of hard exudate and normal regions using the DAISY algorithm based on the histogram of oriented gradients. After, we utilized the recursive feature elimination (RFE) method, using logistic regression (LR) and support vector classifier (SVC) estimators on the raw dataset. Therefore, we obtained two datasets containing the most important features. The number of important features in each dataset created with LR and SVC was 126 and 259, respectively. Afterward, we observed different classifier algorithms' performances by using 5-fold cross validation on these important features' dataset and it was observed that the random forest (RF) classifier is the best classifier. Secondly, we obtained important features from the feature vector that corresponds with the region of interest in accordance with the keypoint information in a new retinal fundus image. Then we performed detection of hard exudate regions on the retinal fundus image by using the RF classifier.

Rate Confirmation ± LONGSHIP Longship P.O. Box 12590 - Lexington, KY 40583 LS PO#: 348020 Phone: (855) 440-2828 Ext: 1176 - Fax: (859) 549-8120 - Email: amullins@longship.us 4/25/2022 5:16 pm Load Information LS PO#: 348020 Pick Up Date: 04/26/2022 Trailer: Delivery Date: Reefer Size: 53 ft Temperature: 38 04/29/2022 Weight: 44,000 CONTINUOUS RUN Miles: Carrier Information Carrier: NATIONAL VISTA TRUCK LLC MC: 1335878 Phone: (786) 480-1996 Fax: Driver: EDDY Driver Cell: (954) 512-0022 Dispatcher: LAURA Dispatcher Phone: (786) 206-8912 Estimated Rate (To The Truck): $4,100.00 Rate $4,100.00 Description Quantity Total FLAT 1 $4,100.00 (Rates based upon weight or count will be calculated from the quantities loaded.) Carrier IS NOT Responsible For Unloading Charges Carrier IS NOT Responsible For Pallet Exchange Pick Ups Shed THOMPSON SEED POTATO - City LUSK WY State Zip 82225 Date Time Phone PU Number 4/26/2022 0800-1600 (308) 762-7699 197292 Shipping Hours: Case/ Piece Count: LUSK Physical Address: 5770 US HWY 20 Commodities: Pallet Count: Truckload BULK potatoes Deliveries Consignee MASSER City State Zip Temp Date Time SACRAMENTO PA 17968 38 4/29/2022 Physical Address: 2 FEARNOT RD MAKE APPT Receiving Hours: Phone (570) 682-3709 Delivery PO 280470 SPECIAL INSTRUCTIONS: MUST HAVE AIR-RIDE, AIR-CHUTE, 2 SETS OF LOAD LOCKS & REEFER MUST BE 2010 OR NEWER. DETENTION IS CASE BY CASE AND DOES NOT APPLY TO FCFS SHIPPERS, FCFS RECIEVERS, OR PRODUCE LOADS. REEFER MUST BE SET ON CONTINUOUS @ ALL TIME. TEMPERATURE IS SPECIFIED ON LOADED BILL OF LADING. IF TEMPERATURE DOESN'T MATCH BOTH BOL AND RATE CONFIRMATION DRIVER MUST NOTIFY BROKER BEFORE LEAVING THE SHIPPER. IF CARRIER IN ANY CAPCITY INCORRECTLY SETS THE TEMPERATURE OR REEFER SETTING, CARRIER TAKES FULL MONETARY RESPONSIBILTIY FOR DAMAGED PRODUCT. UNLOADING/LUMPER RECEIPTS MUST BE SUBMITTED WITH INITIAL POD IN ORDER TO BE REIMBURSED. DRIVER MUST VERIFY COUNTS WHILE LOADING & DISCREPANCIES MUST REPORTED IMMEDIATELY PRIOR TO DEPARTING FROM SHIPPER AND/OR RECEIVER TO AVOID DEDUCTION PENALTIES. CARRIER MUST SCALE AT THE NEAREST SCALE ONCE LEAVING SHIPPER, LONGSHIP WILL NOT PAY FOR EXTRA MILES RAN BY TRUCK FOR MISSED SCALES. DO NOT BREAK SEAL OR LOAD IS CONSIDERED A FULL CLAIM. MUST MAKE ASSIGNED DELIVERY TIME AS STATED ON RATE CONFIRMATION OR LATE FEES COULD APPLY. IN THE EVENT OF A REJECTION OF ANY KIND CARRIER IS RESPONSIBLE FOR RE-DELIVERING 4252022171612Page: 2 Rate Confirmation LS PO#: 348020 THE REJECTED PRODUCT AND COMPENSATION WILL BE NEGOTIATED ON A CASE-BY-CASE BASIS AND WILL NOT EXCEED $2/MILE. VENTED VAN LOADS MUST HAVE FRONT AND REAR PRODUCE VENTS. IF THE CARRIER DOES NOT ACCEPT THESE TERMS, CROSS DOCKING/RECOVERY TRUCK FEES WILL BE TAKEN FROM THEIR ORIGINALLY AGREED UPON RATE. POD & UNLOADING/LUMPER RECEIPTS MUST BE TURNED IN WITHIN 24 HOURS OF DELIVERY. EMAIL TO Amullins@longship.us Call 570-653-1517 to make delivery appointment! 1. 2. 3. 4. 5. 6. 7. 8. 9. For prompt payment please email all paperwork including BOLS, Lumper receipts, Carrier Invoice, etc. to accounting@longship.us or if originals are required mail them to P.O. Box 12590 Lexington, KY 40583. For Quick Pay please email all paperwork to quickpay@longship.us or upload though the TriumphPay App. This load is subject to all terms and conditions of the Broker- Carrier Agreement and all quick pay fees are subject to change at any time without prior notification. All Drivers are required to check call every day (including Sat., Sun., and holidays), between 8:00am and 9:00 am Eastern Time. Failure to provide timely check calls could result in a penalty against the carriers final settlement. Longship is available 24 hours a day 7 days a week. Failure to call immediately could result in a penalty against the final settlement. Driver must have a minimum of 2 load locks to secure the load. A fee of $7.50 per pallet will be charged on loads that the carrier is responsible to supply pallets for exchange and they do not. If any loads are sealed the driver/carrier cannot break any seal or there will be a claim charged to the carrier. Unless originals are required please FAX or EMAIL BOLS to your LS Crew Member email directly to accounting @longship.us. Once paperwork has been received (whichever comes first via e-mail, fax, or mail), no further adjustments can be made. Unloading receipts must be included with initial submission or they will NOT be reimbursed. 10. Detention is handled on a case by case basis and carrier MUST notify LS Crew Member 1 hour before detention begins to accrue. Note: Detention does not apply to produce loads. Loads delivered late may be subject to late fees. 11. Advances are limited to 40% of the linehaul rate. 12. Longship Full truckload shipments (FTL) may NOT be paired with other Less than truckload (LTL) shipments without written permission from a Longship Crew Member or deductions may apply. If you have any comments or concerns about your experience with Longship, please email us at info@longship.us. Your feedback is very important to us. Thank you for helping us better serve our customers! Deec Alex Mullins LS REPRESENTATIVE SIGNATURE Electronically Signed By Laura On 04/25/2022 CARRIER REPRESENTATIVE SIGNATURE Load Summary * IMMEDIATELY FAX A COPY OF THIS SIGNED CONFIRMATION TO (859) 549-8120 Estimated Rate (To The Truck): First Pick: THOMPSON SEED POTATO - LUSK Last Drop: MASSER $4,100.00 5770 US HWY 20 LUSK 2 FEARNOT RD WY 82225 SACRAMENTO PA 17968 4252022171612

One Horn Transportation Name: Lakewood Ranch, FL 34202 USA (973) 333-4922 Fax: (973) 595-7720 One Horn Transportation Broker Tom.Kern Phone: (828) 312-1127 Fax: (973) 900-8859 Email: Tom.Kern@onehorn.com Commodity: Weight: DKK0.00 Pieces: DKK1.00 Requirements Van 1 Load Carrier Rate Confirmation Pro: 123708 Odin Express Disp Name: Nikola Disp Phone: (786) 535-7504 Disp Fax: Disp Cell: Disp Email: Driver Name: Driver Cell: Nikola@smarthop.co Email Invoices to GetPaid@OneHorn.com or Fax to (973)692-6770 We no longer accept mailed invoices Quick Pay Send Invoice and POD to QuickPay@onehorn.com QuickPay Fee (4%+$15 fee) paid by T-Chek(only) same day if possible max 24 hours TCP Packaging 102 Jessica Lane Unit B Del Rio, TX 78840 USA Pick#SC16838232-Statesville NC Plastic parts in boxes on pallets (469) 438-5071 6/17/22 BOLS: 53 dry van w etrac & 3strao pick 8-3 3:30:00 PM 2 UnLoad Wastequip-Toter-Statesville 841 Meacham Rd Statesville, NC 28677 USA Del# BOLS: 8-3 FCFS (704) 682-5605 6/20/22 10:00:00 AM Transport Charge Settlement Info Freight Charge 3,700.00 Total due Carrier as of this date: 6/17/22 $3,700.00 Signer Name: We will pay the following Carrier: Delpech Group Llc Nikola Katusevski With MC#: 80421 Signature: Nikola Katusevski Date: Est. Location: IP Addr: 127.0.0.1 Most Important 1 2 Carrier hereby certifies that this shipment can be completed within the time period stated herein without requiring any driver to exceed any hours of service limitations. Any late fees and/or fines incurred due to Carrier/driver misrepresentation regarding available hours of service will be borne by Carrier and deducted from driver's settlement. Complaints about hours of service and/or coercion must be submitted to our corporate office at (973)595-7700 Ext 108 at the time of the perceived coercion. Driver must Call in for Check Calls every day and following loading and unloading. TCheck Cashing available for fee of $5 per cashing, or $35 per cashing for after-hours requests. Cashing TCheck constitutes acceptance of said fees. 3 4 5 This shipment is subject to the Standard Terms and Conditions set forth on the next page. 6 POD must be sent to GetPaid@onehorn.com within 24 hours of delivery or face $25/day deduction 7 We have revamped our main contract, by accepting and/or transporting this shipment, the carrier agrees to the new terms and conditions, you can get a copy of the contract by visiting our website at www.onehorn.com/carrier-center or follow the link from the email you received from your One Horn Contact Printed: 17-Jun-2022 00:12 www.OneHorn.com Tom.Kern@onehorn.com Powered by Stratebo™ Software 2 PagesOne Horn Transportation Lakewood Ranch, FL 34202 USA (973) 333-4922 Carrier Rate Confirmation Pro: 123708 Fax: (973) 595-7720 Standard Terms and Conditions 1 23 4567 8 Drivers or Dispatchers, MUST Check call before 9:00am every day. We must have Pro#, location and if you are on schedule. We respect our carriers and do not abuse their phone time, however, we expect the same in return. Drivers, Dispatchers must call when loaded and unloaded including multiple stop loads. All invoices must be emailed to GetPaid@onehorn.com or faxed to (973) 692-6770. Missing Lumper receipts will be deducted from settlement. Payment clock starts when we receive the acceptable PODs and invoice marked with our Pro#. Carrier is expressly prohibited from double-brokering any load. Double brokered loads will not be paid. If you are going to be late to a delivery, you will call immediately and notify us. All fines for missed or Late appointments will be deducted from carrier bill. We do have Tchecks. There is a $5 fee associated with cashing each Tcheck. Please plan ahead. You may total up all lumper charges and have one Tcheck, but please cash the whole thing at once. Any leftover from lump sum will be deducted from settlement. Orders for Tchecks stop at 6pm each night. After hours Tcheck will cost $35.00. By accepting and/or transporting this shipment, the Carrier agrees to these Terms and Conditions, and this agreement shall be deemed to be in Full Force and Effective even if unsigned. 9 Please sign both pages of Confirmation and Terms and return to Agent's Fax or email listed above. 10 11 12 Carrier to bill Broker who is solely responsible for freight charges. Carrier shall not seek payment directly from Shipper/ Consignee. Carrier assumes full value responsibility for loss or damage to shipment not to be limited by Insurance capacity or previous agreement. Carrier agrees to be responsible for any additional freight charges and/or transportation costs incurred due to any loss and/or delay while shipment is in Carrier's possession. Carrier assumes responsibility for shipment requiring tarps, whether or not noted on Rate Confirmation. Printed: 17-Jun-2022 00:12 www.OneHorn.com Tom.Kern@onehorn.com Powered by Stratebo™ Software 2 Pages

Interstate X 1211 N Hwy 77 Marietta, OK 73448 Dispatcher Dispatcher: Phone: Fax: Nathaniel Plaza 469-275-4466 855-866-1232 INTERSTATE X Load and Rate Confirmation Agreement Load #53914 Emergency Phone: 469-275-4466 To accept load please sign and email this sheet back to: nathaniel@interstatex.com Carrier Information Load Number: 53914 Carrier Number: 10683 Driver Name: MC Number: 939781 Truck Number: Jerry 6080 Carrier Name: Iship Worldwide Inc Attention: Confirmation Sent Trailer Number: Carrier Phone: Carrier Fax: 6080T 7865357840 To: dortega@smarthop.co Load Information Bill Of Lading: Commodity: 5005784048 CHICKEN Commodity Value: $100,000.00 Dimensions: L:53'; Load Size: Truckload Miles: 855.00 Min Weight: 36,000 PO Number: Pickup Number: Piece Count: Reefer Temp: Trailer Req: Weight: ARCH072 5005784048 900 set per bol Reefer 36,000 #1 Shipper Company: Address: Wednesday, 05/11/2022 at 18:12 City/St/Zip: CARTHAGE MS PROC 3865 HWY 35 N Carthage, MS 39051 Phone: 601-298-5300 DDT: 05/11/2022 22:12 #2 Consignee/Final Destination Friday, 05/13/2022 at 05:00 Company: CONTINENTAL FORWARDING LAREDO Phone: 956-724-5672 Address: 23852 MINES RD City/St/Zip: Laredo, TX 78040 DRIVER WILL NEED CASH FOR LUMPER Additional Information Customer Dispatch Notes: *****ATTENTION***** ALL UNVACCINATED CARRIERS/DRIVERS AND ANY NON-CARRIER EMPLOYEE'S THAT ARE THE CARRIER/DRIVER'S GUESTS MUST FOLLOW ALL COVID-19 PROCEDURES REQUIRED BY TYSON FOODS WHILE AT ANY LOCATIONS OWNED BY TYSON AND ITS SUBSIDIARIES, AND WHILE AT ANY LOCATION THAT IS RECEIVING A SHIPMENT FROM TYSON FOODS, ITS SUBSIDIARIES, AND ITS TEAM PARTNERS NO MATTER WHO OWNS THE PROPERTY DELIVERING TO. DRIVER MUST WEAR A MASK WHEN ENTER ANY OF SAID LOCATIONS AND MUST ONLY BE INSIDE THE BUILDING A MAX OF 10 MINUTES WHILE FOLLOWING ALL PROTOCOLS (i.e. WEAR A MASK AT ALL TIMES WHEN OUTSIDE THE CARRIER'S TRUCK AND/OR WHILE INSIDE CARRIER'S TRAILER.) FAILURE TO DO SO MAY RESULT IN THE LOSS OF CARRIER BEING ALLOWED TO TAKE CURRENT LOAD. REPEATEDLY NOT FOLLOWING THESE RULES MAY ALSO RESULT IN CARRIER/DRIVER BEING REFUSED TO ENTER SAID FACILITIES FOR FUTURE LOADS. ALL LUMPER RECEIPTS MUST BE RECEIVED BY INTERSTATEX WITHIN 48 HOURS OF THAT SPECIFIC DROP IN ORDER TO BE REIMBURSED. THIS MUST BE• • • DONE REGARDLESS IF PAID BY CARRIER OR INTERSTATEX. ALL DETENTION TIME IS TO BE REQUESTED WITHIN 48 HOURS OF LOADING AT THE SHIPPER & WITHIN 48 HOURS OF EACH INDIVIDUAL DELIVERY. (ALL PAPERWORK MUST BE PROVIDED AT TIME OF REQUEST) DETENTION IS PAID ONLY IF YOU ACCEPT 4 KITES TRACKING THROUGHOUT THE DURATION OF THE TRIP & ALL OS&D CLAIMS PROCEDURES ARE FOLLOWED AND CLEARANCE IS GIVEN BY INTERSTATEX. ANY OVERAGE SHORTAGE AND DAMAGE MUST BE REPORTED, IMMEDIATELY UPON RECEIPT OF ALL PW TO INTERSTATEX BY THE DRIVER WHILE STILL AT RECEIVER'S LOCATION & DRIVER MUST OBTAIN CLEARANCE FROM INTERSTATEX BEFORE LEAVING RECEIVER. LEAVING WITHOUT CLEARANCE AND/OR NOT REPORTING TO INTERSTATEX IMMEDIATELY MAY RESULT IN A CARGO CLAIM BEING DEDUCTED FROM PAY SETTLEMENT AND/OR FILED WITH CARRIER'S INS. CARRIER MUST MAKE SURE TO ARRIVE AT THE SHIPPER WITH 3 QUARTERS OR MORE IN REEFER FUEL. ATTENTION: IF PAY LOAD WEIGHT EXPECTED TO BE 36,000 lbs or MORE AN EMPTY WEIGHT SCALE TICKET (CAT CERTIFIED) MUST BE RECEIVED BY INTERSTATEX BEFORE ARRIVING TO THE SHIPPER TO PICK UP THE LOAD. FAILURE TO DO SO WILL RESULT IN ANY FINES, OR FEES NOT BEING REIMBURSED TO CARRIER. IMPORTANT: SET REEFER TEMP PER BOL RUN ALL PRODUCE LOADS ON CONTINUOUS MODE. DO NOT CYCLE OR SET IT ON AUTOMATIC. SAVING $ 100 ON FUEL IS NOT WORTH HAVING A CLAIMED LOAD ON YOUR INSURANCE POLICY. PULP TEMPERATURE FOR ALL PRODUCE LOADS. DUE TO THE NATURE OF THE PRODUCE BUSINESS, NO DETENTION IS PAID ON PRODUCE LOADS. ALL TRAILERS MUST BE CLEAN AND ODOR FEE PRIOR TO ARRIVING FOR PICK UP. MUST ARRIVE WITH 3 QUARTERS OR MORE IN REEFER FUEL FOR PICK UP AND FOR DELIVERY. NOT DOING SO MIGHT RESULT IN GETTING TO GO BACK AND REFUELING BEFORE YOU COULD BE LOADED OR UNLOADED. ALL LUMPERS MUST BE REPORTED WITHIN 24 HOURS OF DELIVERY. RECEIPTS MUST BE TURNED IN WITHIN 3 DAYS OF DELIVERY TO ACCOUNTING@INTERSTATEX.COM FOR THEM TO BE REIMBURSED. WE WANT TO REIMBURSE THE LUMPERS HOWEVER WE NEED THOSE RECEIPT SO WE CAN SEND TO OUR CUSTOMERS AND GET THEM APPROVED. HOWEVER, IF YOU DON'T FOLLOW THIS PROCEDURE WE WILL NOT BE REIMBURSED AND IN RETURN WON'T BE ABLE TO REIMBURSE YOU. ALL PODS MUST BE TURNED IN WITHIN 21 DAYS OF DELIVERY. ANY PAPERWORK TURNED IN 30 DAYS AFTER DELIVERY WILL BE ASSESSED A 3% LATE FEE. MUST PROVIDE CHECK CALLS BY 8 AM AND 3 PM, 7 DAYS A WEEK. A $ 50 PENALTY WILL APPLY FOR MISSED CHECK CALLS. NO EXCEPTIONS. ANY OVERAGE, SHORTAGES OR DAMAGES MUST BE REPORTED TO 469-275-4466 AS AND WHEN THEY HAPPEN. PROOF OF PIC OF PRODUCT AND BOL MUST BE EMAILED TO DISPATCH@INTERSTATEX.COM WHEN THE DRIVER IS AT DELIVERY AND RECEIVES PAPERWORK FROM THE RECEIVER AND GET AN OK FROM US BEFORE HE LEAVES THEIR PROPERTY. FAILURE TO DO SO COULD RESULT IN A CLAIM WHICH NO ONE WANTS. • NO FUEL ADVANCE IS ISSUED UNTIL AFTER YOUR SECOND LOAD. FUEL ADVANCE IS ISSUES ONLY DURING BUSINESS HOURS. $ 1000 A DAY, $ 2000 MAX TOTAL. • • DRIVER MUST ACCEPT 4 KITES TRACKING DURING THE DURATION OF THE ENTIRE TRIP OR THERE WILL BE A $ 300 FINE. NO DETENTION IS PAID IF DRIVER DOES NOT ACCEPT LOAD TRACKING. FAILURE TO ACCEPT TRACKING AND LEAVE IT ON DURING THE ENTIRE TRIP WILL LEAD TO AN AUTOMATIC FORFEIT OF DETENTION. FOR MEAT CHICKEN AND DAIRY LOADS DETENTION IS PAID AFTER FIRST 4 HOURS PROVIDED YOU ARRIVED ON TIME FOR PU. DETENTION CAN ONLY BE REQUESTED FOR FIRST PICK AND FINAL DROP. ALL DETENTION REQUESTS ARE PROCESSED AFTER THE LOAD HAS BEEN DELIVERED. ALL REQUESTS NEED TO GO TO DETENTION@INTERSTATEX.COM WITH IN & OUT TIMES AND COPY OF LEGIBLE POD WITHIN 3 DAYS OF COMPLETION OF DELIVERY. ALL WEIGHTS LISTED ON RATE CONFIRMATION ARE ESTIMATED. THE ACTUAL WEIGHT MAY VARY. WE PAY BY MILE NOT WEIGHT. LATE DELIVERIES CAN RESULT IN A RATE REDUCTION OF $ 1000 A DAY, TO BE ENFORCED AT INTERSTATE X'S DISCRETION. IN CASE OF BREAK DOWN PLEASE PROVIDE PROOF OF BREAKDOWN ETC. WE DO NOT WANT TO CHARGE LATE FEE, HOWEVER IF YOU DON'T COMMUNICATE WITH US YOU LEAVE US WITH NO CHOICE. LOADS PICKING UP AT TYSON FOODS: ALL UNVACCINATED CARRIERS/DRIVERS AND ANY NON-CARRIER EMPLOYEE'S THAT ARE THE CARRIER/DRIVER'S GUESTS MUST FOLLOW ALL COVID-19 PROCEDURES REQUIRED BY TYSON FOODS WHILE AT ANY LOCATIONS OWNED BY TYSON AND ITS SUBSIDIARIES, AND WHILE AT ANY LOCATION THAT IS RECEIVING A SHIPMENT FROM TYSON FOODS, ITS SUBSIDIARIES, AND ITS TEAM PARTNERS NO MATTER WHO OWNS THE PROPERTY DELIVERING TO. DRIVER MUST WEAR A MASK WHEN ENTER ANY OF SAID LOCATIONS AND MUST ONLY BE INSIDE THE BUILDING A MAX OF 10 MINUTES WHILE FOLLOWING ALL PROTOCOLS (i.e. WEAR A MASK AT ALL TIMES WHEN OUTSIDE THE CARRIER'S TRUCK AND/OR WHILE INSIDE CARRIER'S TRAILER.) FAILURE TO DO SO MAY RESULT IN THE LOSS OF CARRIER BEING ALLOWED TO TAKE CURRENT LOAD. REPEATEDLY NOT FOLLOWING THESE RULES MAY ALSO RESULT IN CARRIER/DRIVER BEING REFUSED TO ENTER SAID FACILITIES FOR FUTURE LOADS. • PLEASE SIGN AND RETURN WITH TRUCK #, TRAILER #, DRIVERS NAME AND HIS CELL PHONE#. Amount to invoice: $1,900.00 Carrier: Iship Worldwide Inc MC #: 939781 Invoicing Methods 1. Email (preferred): Standard Pay (21 days): finance@interstatex.com Quick Pay (processed every Thursday, bills must be turned in by Wednesday to be paid on Thursday) quickpay@interstatex.com 2. US Mail: Interstate X 1211 N Hwy 77 Marietta, OK 73448By: Title: Daniela Ortega Booking Agent

COYOTE Rate Confirmation Send invoices to: Load 26603637 CarrierInvoices@coyote.com 960 Northpoint Parkway Suite 150 Alpharetta, GA 30005 Cust Requirements Equipment Reefer, 53' Pre Cooled Temp 68.0 °F * Load Temp 68 - 68 °F * Continuous Tarps Value Ship Type Undefined $100,000 Transload See BOL for Final Temp Booked By Sean Moakler sean.moakler@coyote.com Phone: +1 (773) 634 1627 X6411 Fax: +1 (773) 365 8948 Load Requirements CTPAT Border Crossing By Coyote Transload By Coyote Equipment Requirements Food Grade T Get • Dispatch 877-6COYOTE (877-626-9683) CoyoteGO Today! . Send updates • Check in • Submit paperwork Available for An- droid or iPhone, at App Store or Google Play Notes All Van/Container loads MUST be sealed at origin either by shipper or driver with a seal number noted on bill of lading. The driver is responsible for re-sealing the trailer after each pickup/drop on a multi-stop shipment. In the event a shipment that was sealed at origin or after each additional pickup/drop arrives at the destination with a tampered seal or without the seal intact then (i) the Carrier shall be liable for any shortage or damage claims with respect to such shipment and (ii) the shipper shall have the right, in its sole discretion, to deem the entire shipment damaged, adulterated/contaminated and unsalvageable, without the need for any inspection and the Carrier shall be liable for the full value of the shipment. Carrier is required to weigh shipment within 50 miles of departing each shipper. If carrier fails to weigh shipment within 50 miles of departing each shipper, any citations/expenses incurred due to the equipment and/or shipment weight will be the carrier's sole responsibility. Carrier must meet and comply to shipper requirements at the facility. All drivers must wear masks or facial coverings to the extent required by laws or facilities. Carrier must be in full compliance with the Food Safety Modernization Act (FSMA), if applicable. Reefer Unit must have temp download capability. By accepting the shipment, Carrier agrees that the driver has consented to receiving text messages and/or phone calls from or on behalf of Coyote. Approval for payment of detention is contingent upon the following eligibility requirements: 1) Carrier must report facility departure time and total detention hours within 24 hours of shipment delivery at the final facility. 2) Carrier must provide proof of the on time arrival and departure times in the form of a BOL or other shipping document with arrival and departure times notated by facility within 24 hours of shipment delivery at final facility. Route Directions Carrier acknowledges that any routing instructions from the shipper herein are being provided for convenience only, and the Carrier may choose the route. Signature Line By signing below, IShip Worldwide Inc agrees to the terms and conditions set forth below and provided herewith, if any. [Load Number - 26603637] [Carrier Legal Name - IShip Worldwide Inc] [Carrier USDOT - 2818784] Page 1 of 4COYOTE Rate Confirmation Stop 1: Pick Up Pick Up 26557985 Numbers Confirmation None Numbers Facility Cold Chain Solutions Address 810 UNION PACIFIC BLVD Laredo, TX 78045-9476 Pickup On Fri 04/22/2022 from 08:00-17:00 PLEASE CALL COYOTE TO SCHEDULE AN APPOINTMENT Driver Work Assist/Check Contact Erwin Hechter Phone +1 (956) 796 1795 SLIC N/A Stop 1 Requirements Load 26603637 Facility Notes DUMMY LOAD DUMMY LOAD PLS BOOK REAL LD 26557985 Food Grade MX carrier: Seal number will be needed to be reported to Coyote, must match the one shipper is providing USA carrier: TRL # needed Carrier liable to confirm trailer was sealed properly. PLEASE UPDATE BAZ ONCE REEFER ARRIVE TO CCS! N/A Commodity Airheads & Mentos Load On Exp Wt Pallets Directions are provided for convenience only. The Carrier may choose the route. From Chicago, IL: 30,000 Lbs Carriers may also call 877-6-COYOTE for directions if needed. Stop 2: Delivery Delivery None Numbers Confirmation None Numbers Facility Perfetti Van Melle DC Address 650 ERLANGER RD Erlanger, KY 41018 Deliver On Mon 04/25/2022 PLEASE CALL COYOTE TO SCHEDULE AN APPOINTMENT Driver Work No Touch Facility Notes Seal # and TRLR number needed for del appt Contact Michael Cooke SLIC N/A Phone +1 (859) 283 6956 Stop 2 Requirements Strict Appt Commodity Airheads & Mentos Charges [Load Number - 26603637] [Carrier Legal Name - IShip Worldwide Inc] [Carrier USDOT - 2818784] Load On Pallets Exp Wt 30,000 Lbs Contact Page 2 of 4COYOTE Description Flat Rate Fuel Surcharge Total Rate Confirmation Units Per Amount 1.00 $3,197.300 $3,197.30 1355.00 $0.740 Agreement Carrier IShip Worldwide Inc USDOT 2818784 Phone +1 (786) 420 8167 Email jristano@smarthop.co Fax None Load 26603637 Send invoices to: $1,002.70 960 Northpoint Parkway Suite 150 USD $4,200.00 Alpharetta, GA 30005 Please contact Coyote at 877-626-9683 if the charges are incorrect. Broker Coyote Logistics, LLC Rep Sean Moakler Title Sales Rep Phone +1 (773) 634 1627 x6411 Fax +1 (773) 365 8948 Date 04/21/2022 08:22 By signing below, IShip Worldwide Inc agrees to the terms and conditions set forth below and provided herewith, if any. Name and Title (Print) Signature Date PLEASE SIGN THIS AGREEMENT AND EMAIL TO sean.moakler@coyote.com Coyote Logistics, LLC is an Equal Opportunity Employer [Load Number - 26603637] [Carrier Legal Name - IShip Worldwide Inc] [Carrier USDOT - 2818784] Page 3 of 4COYOTE Rate Confirmation Terms and Conditions Load 26603637 The Broker-Carrier Agreement or Carrier Agreement (in each case, the "Agreement") between Coyote Logistics, LLC, a Licensed Property Broker - USDOT # 2236410, and IShip Worldwide Inc is amended by the verbal agreement between Sean Moakler of Coyote Logistics, LLC hereafter referred to as BROKER, and Juan Ristano of IShip Worldwide Inc hereafter referred to as CARRIER, dated 04/21/2022. This confirmation is subject to the terms of the Agreement and this document constitutes an amendment thereto. If the CARRIER has not signed the Agreement, then the rate shown above is the agreed individually negotiated rate and no other rate shall apply including any carrier tariff rate or terms. THIS LOAD SHALL NOT BE DOUBLE BROKERED. No additional charges not listed above may be added by the CARRIER. Any additional charges must appear on a revised confirmation sheet signed by the BROKER. CARRIER must include signed copy of the shipper's bill of lading and any other proof of delivery with invoice to BROKER. Rates, except as specifically designated above, are inclusive of any fuel surcharge. CARRIER certifies that it is in compliance with all requirements of the California Air Resources Board (CARB) that are applicable to the scope of CARRIER's operations, including, but not limited to: Statewide Truck and Bus Regulations, Transport Refrigeration Unit (TRU) Regulations, Tractor-Trailer Greenhouse (GHG) Gas Regulations, and Drayage Truck Regulations. CARRIER also warrants that it is in compliance with any comparable requirements of the Environmental Protection Agency (EPA) and other states, where applicable. CARRIER shall be responsible for any fines imposed on BROKER and/or shipper resulting from noncompliance. CARRIER hereby confirms that it maintains applicable and valid insurance without exclusions that would prevent coverage for the items listed above. CARRIER has at least $100,000.00 in cargo insurance and $1,000,000.00 in automobile liability coverage. CARRIER further confirms that in transporting the shipment described hereinabove, it will comply with all U.S. DOT and FDA regulations applicable to its operations while transporting said shipment, including, but not limited to drivers' hours of service, and the Food Safety Modernization Act (FSMA), if applicable. CARRIER agrees to the attached requirements from the shipper, if any. ALL LOADS ARE SUBJECT TO ELECTRONIC TRACKING By accepting this shipment, CARRIER agrees that it has obtained a written agreement from each driver transporting a shipment tendered by BROKER to CARRIER pursuant to the Agreement in which each driver provides all necessary consents to (i) receiving text messages and/or phone calls from or on behalf of BROKER and (ii) allowing BROKER or its vendor to track such driver's location while transporting such shipment. CARRIER shall comply with all applicable laws relating to the collection, use, storage, retention, disclosure, and disposal of any information CARRIER provides to BROKER, including information regarding the drivers transporting shipments. CARRIER shall indemnify, defend, and hold BROKER and its affiliates harmless from and against any and all claims, damages, liabilities, losses, actions and expenses (including attorneys' fees) arising out of or in connection with CARRIER's breach of this Section. This Section shall survive the expiration or termination of the Agreement between BROKER and CARRIER. PROCESSING OF PERSONAL INFORMATION With regard to personal information (information that describes, is capable of being associated with, or could reasonably be linked, directly or indirectly, with a particular consumer, household, or device) and data and/or information submitted by or on behalf of BROKER in connection with the shipment, CARRIER will only use and process such data and/or information for the purpose of performing the services hereunder and in compliance with applicable law. With regard to personal information collected, received, or otherwise used or processed by CARRIER hereunder, CARRIER shall not: (i) (ii) Sell, rent, release, disclose, disseminate, make available, transfer, or otherwise communicate orally, in writing, or by electronic or other means, personal information to another business or a third party for monetary or other valuable consideration; or Retain, disclose, collect, sell, use, or otherwise process personal information for any purpose other than for the specific purpose of, and as necessary for, performing the services hereunder. For clarity, CARRIER may not retain, use, or disclose the personal information for any other commercial purposes or outside of the direct business relationship between CARRIER and BROKER. CARRIER will notify BROKER promptly via email at privacy@coyote.com within 2 business days of any breach of the requirements under this heading (PROCESSING OF PERSONAL INFORMATION) of if it receives any inquiry, complaint, request or claim from an individual relating to personal information. CARRIER will notify BROKER by emailing privacy@coyote.com within 24 hours of any security incident of which CARRIER becomes aware which affects, or could reasonably be expected to affect, the confidentiality, integrity, or availability of BROKER's information systems or any personal information, data, and/or information submitted by or on behalf of Broker in connection with the shipment. [Load Number - 26603637] [Carrier Legal Name - IShip Worldwide Inc] [Carrier USDOT - 2818784] Page 4 of 4

Human activity recognition has been widely studied since the last decade in ambient intelligence scenarios. Remarkable progresses have been made in this domain, especially in research lines such as ambient assisted living, gesture recognition, behaviour detection and classification, etc. Most of the works in the literature focus on activity classification or recognition, prediction of future events, or anomaly detection and prevention. However, it is hard to find approaches that do not only recognize an activity, but also provide an evaluation of its performance according to an optimality criterion. This problem is of special interest in applications such as sports performance evaluation, physical therapy, etc. In this work, we address the problem of the evaluation of such human activities in monitored environments using depth sensors. In particular, we propose a system able to provide an automatic evaluation of the correctness in the performance of activities involving motion, and more specifically, diagnosis exercises in physical therapy.

Addictions, including alcohol use disorders, are characterized by the loss of control over drug seeking and consumption, but the neural circuits and signaling mechanisms responsible for the transition from controlled use to uncontrolled abuse remain incompletely understood. Prior studies have shown that compulsive-like' behaviors in rodents, for example, persistent responding for ethanol (EtOH) despite punishment, are increased after chronic exposure to EtOH. The main goal of the current study was to assess the effects of chronic intermittent EtOH (CIE) exposure on multiple, putative measures of compulsive-like EtOH seeking in C57BL/6J mice. Mice were exposed to two or four weekly cycles of CIE and then, post-withdrawal, tested for progressive ratio responding for EtOH, sustained responding during signaled EtOH unavailability and (footshock) punished suppression of responding for EtOH. Results showed that mice exposed to CIE exhibited attenuated suppression of EtOH seeking during punishment, as compared with air-exposed controls. By contrast, CIE exposure affected neither punished food reward-seeking behavior, nor other putative measures of compulsive-like EtOH seeking. Ex vivo reverse transcription polymerase chain reaction analysis of brain tissue found reduced sensitivity to punished EtOH seeking after CIE exposure was accompanied by a significant increase in gene expression of the GluN1 and GluN2A subunits of the N-methyl-d-aspartate receptor, specifically in the medial orbitofrontal cortex. Moreover, slice electrophysiological analysis revealed increased N-methyl-d-aspartate receptor-mediated currents in the orbitofrontal cortex after CIE exposure in test-naive mice. Collectively, the current findings add to the growing body of evidence demonstrating that chronic exposure to EtOH fosters resistance to punished EtOH seeking in association with adaptations in cortical glutamatergic transmission.

Psychosocial rehabilitation programs received mental health professional support in addition to traditional medication therapy. Many psychosocial programs were developed since the 1990s, including cognitive remediation therapy. In this review, we focus on cognitive remediation therapy in Korea since the 1990s. We review several cognitive rehabilitation programs developed in Korea and their outcome studies and suggest future research directions and prospects. We reviewed cognitive rehabilitation programs including social cognitive training as well as more recent forms of computerized cognitive rehabilitation. Although there are differences in cognitive domains by training targets, almost all neurocognitive remediation trainings in Korea have beneficial effects on early visual processing, various attention types, and executive function. Future studies need to investigate the mechanisms and various mediators underlying the relationships between cognitive functions and functional outcomes. With more comprehensive cognitive and social cognitive programs, we can enhance both cognition and functional outcomes of the patients with schizophrenia. (C) 2016 Elsevier B.V. All rights reserved.

A theoretical model is proposed that specifies lay causal theories of behavior; and supporting experimental evidence is presented. The model's basic assumption is that different types of behavior trigger different hypotheses concerning the types of causes that may have brought about the behavior. Seven categories are distinguished that are assumed to serve as both behavior types and explanation types: goals, dispositions, temporary states such as emotions, intentional actions, outcomes, events, and stimulus attributes. The model specifies inference rules that lay people use when explaining behavior (actions are caused by goals; goals are caused by higher order goals or temporary states; temporary states are caused by dispositions, stimulus attributes, or events; outcomes are caused by actions, temporary states, dispositions, stimulus attributes, or events; events are caused by dispositions or preceding events). Two experiments are reported. Experiment 1 showed that free-response explanations followed the assumed inference rules. Experiment 2 demonstrated that explanations which match the inference rules are generated faster and more frequently than non matching explanations. Together, the findings support models that incorporate knowledge based aspects into the process of causal explanation. The results are discussed with respect to their implications for different stages of this process, such as the activation of causal hypotheses and their subsequent selection, as well as with respect to social influences on this process.

People read dominance, trustworthiness and competence into the faces of politicians but do they also perceive such social qualities in other nonverbal cues? We transferred the body movements of politicians giving a speech onto animated stick-figures and presented these stimuli to participants in a rating-experiment. Analyses revealed single body postures of maximal expansiveness as strong predictors of perceived dominance. Also, stick-figures producing expansive movements as well as a great number of movements throughout the encoded sequences were judged high on dominance and low on trustworthiness. In a second step we divided our sample into speakers from the opposition parties and speakers that were part of the government as well as into male and female speakers. Male speakers from the opposition were rated higher on dominance but lower on trustworthiness than speakers from all other groups. In conclusion, people use simple cues to make equally simple social categorizations. Moreover, the party status of male politicians seems to become visible in their body motion. (C) 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

LANDSTAR EFFECTIVE DATE: EQUIPMENT: 11/16/2023 D-ST CARRIER: CARRIER #: DRIVER: COMMODITY: Displays DIMENSION: WEIGHT: PIECES: 4500 LANDSTAR LOAD CONFIRMATION FB #: 4934467 715 LOGISTICS INC ***** **4080 LRGR - LHT SIGN THIS DRIVER CELL: DOCUMENT CONTACT: PHONE: FRANCISCO MOLSALVE (980) 298-8786 High Risk: TARP: ANY QUESTIONS OR CONCERNS ABOUT THIS LOAD PLEASE CALL AGENCY: (870) 650-4080 X182 IMPORTANT: Carrier call agent if your dispatch instructions below differ from bill of lading! 11/17/2023 05:00 - 11/17/2023 12:00 PICK-UP DATE: NAME/ADDRESS: The Lyons Companies 11301 Electron Drive LOUISVILLE, KY 40299 CONTACT: PHONE: DIRECTIONS: SPECIFIC INSTRUCTIONS: DELIVERY DATE: NAME/ADDRESS: DRIVER MUST OPT INTO TRACKING AND TRACK THE ENTIRE TRANSIT. Box truck with liftgate and pallet jack. 2 straps needed. 3-5 blankets needed. No partial. 11/20/2023 08:00 - 11/20/2023 15:00 Dollar Tree 130 South Nova Road CONTACT: PHONE: ORMOND BCH, FL 32174 DIRECTIONS: SPECIFIC INSTRUCTIONS: ADDITIONAL INSTRUCTIONS: TOTAL CARRIER PAYS ALL INCLUSIVE. Check calls are required every morning by 8 am CST. Failure to do so will result in a $250 fine. Drivers must call LANDSTAR upon arrival and departure of each shipping point and must call upon arrival at destination. This is the exclusive use of equipment unless otherwise noted. Only Consignee can break a seal. Failure to do so will result in a fine. LANDSTAR must be notified of any overages, shortages, or damaged products immediately upon delivery. Failure to do so will result in a 50% fine. LANDSTAR must be made aware of any problems during transit that may result in a delay in delivery/ missed pick up. Failure to do so will result in a 50% fine. The carrier shall be liable to LANDSTAR for all economic loss, including consequential damages that are incurred by Broker or the Customer for any freight loss, damage or delay. Unloading must be reported within 2 hrs. The driver must call upon arrival at the shipper and receiver also a departure of the shipper and receiver along with the pieces, weight, BOL and POD information. Failure to do so will result in a 50% fine. Loading/unloading receipts must be provided within 24 hours or they won't be paid. POD must be emailed or faxed within 24 hrs, failure to do so will result in a 25% fine. Total Carrier Pay: $1,600.00 GET PAID IN 2 DAYS! CALL 1-866-321-PLUS (7587) TO LEARN HOW! Landstar Agent: Agency Contact: Agency Phone: Signature LRGR-LHT Jim Carrier: Carrier 715 LOGISTICS INC (870) 650-4080 X182 Signature: Francisco Monsalve 11/16/2023 ✗ ATTENTION Carrier certifies it is aware of the California Air Resources Board's Truck and Bus, Drayage and Greenhouse Gas Rules and that, on all loads originating in, destined for or passing through California, Carrier will utilize only vehicles that are compliant with those Rules. Please see CARB Regulations, including the CARB Dray rules. https://www.arb.ca.gov PAGE 1 OF 2LANDSTAR * Confirm Date: LANDSTAR LOAD CONFIRMATION FB #: 4934467 Carrier Fax: 0 Confirm Date: 11/16/2023 11/16/2023 CARRIER MUST SIGN LOAD CONFIRMATION AND FAX BACK TO AGENCY AT: 870-686-0255 THANK YOU FOR DOING BUSINESS WITH LANDSTAR TO VIEW ALL AVAILABLE LANDSTAR LOADS ACCESS www.LandstarBroker.com ** CALL OUR INTERACTIVE VOICE RESPONSE SYSTEM TO REPORT LOAD STATUS ** (800) 972-9490 IMPORTANT BILLING INSTRUCTIONS! *** YOUR INVOICE, BILL OF LADING, PROOF OF DELIVERY, AND THIS SIGNED LOAD CONFIRMATION ARE REQUIRED FOR PAYMENT. RECEIPTS (LUMPER, TOLLS, ETC.) AND COPIES OF PERMITS AND/OR ESCORT INVOICES MUST BE SUBMITTED. Carrier Payable questions? Call 800-435-1791 opt 2. PLEASE SEND PAPERWORK TO: LANDSTAR SAVINGS PLUS MEMBERS SEND TO: LANDSTAR RANGER ATTN: BROKERAGE BILLING P.O.BOX 19139 Jacksonville, FL 32245-9139 LANDSTAR RANGER ATTN: BROKERAGE BILLING - LSP P.O.BOX 19119 Jacksonville, FL 32245-9119 FOR EXPRESS MAILINGS USE: LANDSTAR RANGER ATTN: LSP - IMAGING 1000 SIMPSON ROAD ROCKFORD, IL 61102 *** ENDS CONFIRMATION *** ATTENTION Carrier certifies it is aware of the California Air Resources Board's Truck and Bus, Drayage and Greenhouse Gas Rules and that, on all loads originating in, destined for or passing through California, Carrier will utilize only vehicles that are compliant with those Rules. Please see CARB Regulations, including the CARB Dray rules. https://www.arb.ca.gov PAGE 2 OF 2

In recent years, the field of neuroimaging has undergone dramatic development. Specifically, of importance for clinicians and researchers managing patients with epilepsies, new methods of brain imaging in search of the seizure-producing abnormalities have been implemented, and older methods have undergone additional refinement. Methodology to predict seizure freedom and cognitive outcome has also rapidly progressed. In general, the image data processing methods are very different and more complicated than even a decade ago. In this review, we identify the recent developments in neuroimaging that are aimed at improved management of epilepsy patients. Advances in structural imaging, diffusion imaging, fMRI, structural and functional connectivity, hybrid imaging methods, quantitative neuroimaging, and machine-learning are discussed. We also briefly summarize the potential new developments that may shape the field of neuroimaging in the near future and may advance not only our understanding of epileptic networks as the source of treatment-resistant seizures but also better define the areas that need to be treated in order to provide the patients with better long-term outcomes.

In May 2011 in Turkana County, north-western Kenya, tissue samples were collected from goats suspected of having died of peste des petits ruminant (PPR) disease, an acute viral disease of small ruminants. The samples were processed and tested by reverse transcriptase PCR for the presence of PPR viral RNA. The positive samples were sequenced and identified as belonging to peste des petits ruminants virus (PPRV) lineage III. Full-genome analysis of one of the positive samples revealed that the virus causing disease in Kenya in 2011 was 95.7% identical to the full genome of a virus isolated in Uganda in 2012 and that a segment of the viral fusion gene was 100% identical to that of a virus circulating in Tanzania in 2013. These data strongly indicate transboundary movement of lineage III viruses between Eastern Africa countries and have significant implications for surveillance and control of this important disease as it moves southwards in Africa.

The opportunities and challenges related to Internet use continue to grow, as well as the social concern around problematic Internet use (PIU), online risky behaviors, and the intensive use of Internet, mainly among adolescents. The aim of this study was to conduct a general screening of PIU in a large sample of school-based adolescents in Spain (n=40,955), providing updated prevalence data of PIU and different online risky practices, as well as rates of Internet and social network use. Differences between problematic and nonproblematic users were explored in terms of demographics, parental control, and motivations for using. The association between PIU and the involvement in other online risky behaviors was also analyzed, as well as the role of intensive use. The findings show that the global prevalence of PIU among Spanish adolescents is 16.3 percent although this is higher among females, those in their late teens, intensive users, and those without parental control. Logistic regression confirmed that both PIU and intensive use are risk factors for being involved in any online risky behavior. A tentative explanation could be that there is a common deficit of personal and social skills underlying PIU, intensive use, and most online risky practices. From our perspective, value-based education and life skills training are the best way to reach responsible and sensible use of Internet among adolescents. Parents, schools, institutions, and adolescents themselves are called upon to actively engage in facing this problem.

Estimating the nature and extent of human cancer risks due to arsenic (As) in drinking water is currently of great concern, since millions of persons worldwide are exposed to arsenic, primarily through natural enrichment of drinking water drawn from deep wells. Humans metabolize and eliminate As through oxidative methylation and subsequent urinary excretion. While there is debate as to the role of methylation in activation/detoxification, variations in arsenic metabolism may affect individual risks of toxicity and carcinogenesis. Using data from three populations, from Mexico, China, and Chile, we have analyzed the distribution in urine of total arsenic and arsenic species (inorganic arsenic (InAs), monomethyl arsenic (MMA), and dimethyl arsenic (DMA)). Data were analyzed in terms of the concentration of each species and by evaluating MMA:DMA and (MMA + DMA):InAs ratios. In all persons most urinary As was present as DMA. Male:female differences were discernible in both high- and low-exposure groups from all three populations, but the gender differences varied by populations. The data also indicated bimodal distributions in the ratios of DMA to InAs and to MMA. While the gene or genes responsible for arsenic methylation are still unknown, the results of our studies among the ethnic groups in this study are consistent with the presence of functional genetic polymorphisms in arsenic methylation leading to measurable differences in toxicity. This analysis highlights the need for continuing research on the health effects of As in humans using molecular epidemiologic methods. (C) 2003 Elsevier Science (USA). All rights reserved.

Tauopathies encompass a broad range of neurodegenerative diseases featuring extensive neuronal death and cognitive decline. However, research over the past 30 years has failed to significantly advance our understanding of how tau causes dementia, limiting the design of rational therapeutics. It has become evident that we need to expand our understanding of tau in physiology, in order to delineate how tau may contribute to pathology. This review discusses recent evidence that has uncovered a novel aspect of tau function, based on its previously uncharacterized localization to the synapse. Here, multiple streams of evidence support a critical role for synaptic tau in the regulation of synapse physiology. In particular, long-term depression, a form of synaptic weakening, is dependent on the presence of tau in hippocampal neurons. The regulation of tau by specific phosphorylation events downstream of GSK-3 beta activation appears to be integral to this signaling role. We also describe how the regulation of synapse physiology by tau and its phosphorylation may inform our understanding of tauopathies and comorbid diseases. This work should provide a platform for future tau biology research in addition to therapeutic design.

Shipping Instructions & Rate Confirmation Bill To: Planet Freight Inc Attn: Accts Payable PO Box 472 Neenah WI 54957 apinvoices@planetfreight.com PlanetFREIGHT Order #: ARIEN5892485 Pickup Date: 03/18/2022 Mode: Truckload PRO #: 5892485 Carrier Carrier Phone Carrier Fax Equipment Total Amount FREZCO TRANSPORTATION COMPANY LLC MC1086906 (719) 359-0382 53' Van $5,200.00 Broker Contact Name Broker Contact Phone JOSEPH PETERSON (414) 240-5436 Origin Liquid Combustion Tech 7302 26th Street E Fife, WA, 98424, US Appointment/Hours Pickup Appointment: 03/18/2022 FCFS Dock Hours: between 8:00 and 16:00 Weight 42,064 lbs # Units 18 Special Instructions: CONTAINER TGBU9824660 Delivery ARIENS - KENOSHA WHSE WSI 3737 84TH AVE Kenosha, WI, 53144, US Appointment/Hours Delivery Appointment: 03/22/2022 13:00 Dock Hours: between 7:00 and 21:00 Weight 42,064 lbs # Units 18 Special Instructions: CONTAINER TGBU9824660 Broker Contact Email josephp@planetfreight.com Phone: 864 660 8013 Special Services None Selected Freight Description Lawn Equipment PO #: 641938612 Shipper Info: 990000007306 RECVNG Phone: 920 831 3714 Email: WSIARIENSTRANSPORTATION@WSINC.COM Special Services None Selected Freight Description Lawn Equipment PO #: 990000007306 Shipper Info: powered by Logistically TMS Shipping Instructions & Rate Confirmation Page 1 of 2Payment: Line Haul: $5,200.00, Special Services: $0.00, Fuel Surcharge: $0.00, TOTAL: $5,200.00 Carrier File Upload & Tracking Link source=rate-confirmation Manual link: https://planetfreight.logisticallytms.com/carrier/#/orders/bcc48e58-edda-4212-b8fc-9e8eeb30dd50/upload? Need help? http://logisticallyinc.com/guide/qr Signed By: (Planet Freight) 03/18/2022 Date: Signed By: Date: (FREZCO TRANSPORTATION COMPANY LLC) powered by Logistically TMS Shipping Instructions & Rate Confirmation Page 2 of 2

Date: AMINO This Rate Confirmation must be accepted before the driver can be dispatched. Rate Confirmation Load #: Main Contact: Name: Joanna Zuniga • Email: joanna@shipamino.com • Phone: (469) 200-3886 Contact After-Hours • Email: afterhours@shipamino.com • Phone: (469) 902-6226 • Hours (Central Time Zone) ○ Sunday: 12:00 - 22:30 O Monday - Thursday: 14:30 - 01:00 ○ Friday: 11:30 - 22:00 Saturday: 08:00 - 18:30 MC #: Carrier: Contact: Phone: Equipment: Weight: Accessorial(s): • 10/16/2023 111812-F MC1459611 715 LOGISTICS INC Francisco 980--298-8786 Straight Truck 26' 3000 lbs Driver Assist (Pickup) • Liftgate (Pickup)Expected Date: Appointment Time: Shipping/Receiving Hours: Location: Total Weight: Item Number: Description: Expected Date: Appointment Time: Shipping/Receiving Hours: Location: Total Weight: Item Number: Description: Charges Net Freight Charge: Fuel Surcharge: Transportation Total: Total Rate: STOP 1 PICKUP STOP 2 DELIVERY 10/16/2023 07:00-14:00 Marquette, MI 49855 Item Summary 3000 lbs 12 Pallets, Equipment, 3000 lbs 10/17/2023 08:00-15:00 Minneapolis, MN 55418 Item Summary 3000 lbs 12 Pallets, Equipment, 3000 lbs $1,000.00 $1,000.00 $1,000.00 Double brokering of this load is prohibited and will result in NO pay. ***To expedite payment, please email the signed BOL(s) and/or POD(s) to ap@shipamino.com within 48 hours of delivery. If not submitted within this timeframe, a $50 late fee may be incurred. *** **We offer payments via ACH. Please email ap@shipamino.com and request the form for setup** Billing Address: DO NOT SEND DRIVER TO BILLING ADDRESS 2320 Dean Way, Suite 160 Southlake, TX 76092Billing Email: ap@shipamino.com • Total Rate includes miscellaneous charges. • Drivers must call to be DISPATCHED. • Driver must call loaded from loading dock and confirm load is secure. • Driver must report shortages/overages/damages before leaving unloading dock. • Late deliveries and missed appointments subject to $250 late charge PER DAY unless otherwise specified. • Fuel surcharge is not applicable. • Carrier agrees not to "Back-Solicit" Amino Transport's customers. • By signing the Rate Confirmation, Carrier confirms there are no discrepancies between the Rate Confirmation and Bill of Lading, and acknowledges it is solely liable for any loss or damage incurred due to any such discrepancy. • If a discrepancy between the Rate Confirmation and Bill of Lading is encountered at the shipper, Driver shall notify Amino Transport immediately, and no change to loading information shall be made until confirmed in writing by Amino Transport. • By accepting this shipment, Carrier certifies that it is aware of the California Air Resource Board ("CARB") regulations and warrants its compliance with the requirements of those regulations. Carrier represents and warrants that the vehicle and equipment used to transport the Load # in this Rate Confirmation are CARB compliant and agrees to defend, indemnify and hold Amino Transport and its customer harmless from and against claims, actions, demands, liabilities, losses, damages, fines, penalties, costs and expenses (including, without limitation, costs, expenses and reasonable attorneys' fees) resulting or arising from Carrier's use or operation of a vehicle or equipment that fails to comply with CARB regulations. • Amino Transport and Carrier each acknowledges and agrees that the other may record telephone conversations and authorizes and consents to the recording of conversations by means of electronic telephone recording equipment or otherwise, without the use of an automatic tone warning device, and without assuming responsibility to make or retain such tape recordings. This Rate Confirmation must be accepted before the driver can be dispatched. Printed Name Quick Pay is available. Please request the quick pay form for complete details/requirements from Joanna Zuniga. Francisco MonsalveSignature Francisco Monsalve Electronically signed on 10/16/2023 12:12:27 GMT

Amyloid- (A) precursor protein (APP) metabolism engages neuronal endolysosomal pathways for A processing and secretion. In Alzheimer's disease (AD), dysregulation of APP leads to excess A and neuronal dysfunction; suggesting that neuronal APP/A trafficking can be targeted for therapeutic gain. Cathepsin B (CatB) is a lysosomal cysteine protease that can lower A levels. However, whether CatB-modulation of A improves learning and memory function deficits in AD is not known. To this end, progenitor neurons were infected with recombinant adenovirus expressing CatB and recovered cell lysates subjected to proteomic analyses. The results demonstrated Lamp1 deregulation and linkages between CatB and the neuronal phagosome network. Hippocampal injections of adeno-associated virus expressing CatB reduced A levels, increased Lamp1 and improved learning and memory. The findings were associated with the emergence of c-fos + cells. The results support the idea that CatB can speed A metabolism through lysosomal pathways and as such reduce AD-associated memory deficits.

The extraction of molten iron and slag in the liquid phase from the lower part of a blast furnace (hearth) is usually accomplished according to operational experience and involves a high degree of uncertainty, mainly because the liquid level cannot be directly measured. This study presents a methodology for obtaining multistep models to forecast the hearth liquid level by measuring a voltage generated on the blast furnace shell, which is strongly correlated with the hearth liquid level. The results show that this electrical signal is a nonstationary and nonlinear time-series that, after appropriate treatment, can be represented by a time-delay neural network (TDNN) model. Some comparisons are made with linear time-series models represented by an autoregressive moving average model and a seasonal autoregressive integrated moving average model, and the results indicate that the TDNN model provides better forecasting performance up to one hour ahead. Note to Practitioners-This work was motivated by the need for better knowledge regarding the liquid level in a blast furnace hearth because this information affects the strategy of the opening and closing of tapholes in the blast furnace and, consequently, the production control and operational quality. Due to the difficulties of measuring the liquid level in the hearth directly, a system was installed that uses a voltage generated in the hearth shell as a liquid-level sensor in the hearth. In this study, the analysis and treatment of this signal is performed by achieving a stationary, nonlinear signal strongly correlated with the level of molten iron and slag inside the blast furnace hearth. A mathematical model that represents this signal was developed and implemented online in the blast furnace digital control system to enable forecasting of the liquid level up to one hour ahead. This computational tool aids operators and engineers in deciding in advance the instants to open or close the tapholes, thereby increasing safety and financial gains.

An improved solution for drug distribution is presented in this paper. It is divided into two parts: i) a multi-operator evolutionary algorithm in charge of calculating the initial delivery routes and ii) an ambient intelligence-based support system able to tracing the merchandise along the distribution route. The first one establishes the routes to be followed by the vehicles, based on a proposal of estimation of the travel times. The second one is formed by a system able to recognize and trace the drugs inside each vehicle. A laboratory experimentation has been conducted in order to demonstrate the adequacy of the route calculator. In addition, a field experimentation has been carried out by implementing the traceability system in a delivery van which of the drug distributor in the city of Bilbao. Note to Practitioners-Motivated by the specific needs found by a drug distributor in managing deliveries to pharmacies involved in its supply chain, this paper considers an optimization problem as the proper way to model the particularities found in this scenario. This paper proposes the use of a combinatorial optimization problem as the way to model problems. Due to the fact that distributor's clients are located in different cities, the proposal considers travel times both between cities and inside the city. In addition, rush hours are also taken into account, in order to provide a more realistic model. Finally, a radio frequency identification-based solution is proposed, in order to implement traceability in the delivered products, as well as to prevent human errors. Additionally, in case an unavoidable error occurs, the solution offers also an incident management mechanism.

This paper presents a technique to reduce torque ripple in a fractional-slot PM brushless machine. A 12-slot/10-pole machine equipped with various stators design is the subject of investigation. A better torque performance at rated condition is desirable when additional permanent magnets are inserted on the stator part. The design optimization process on motor topology is performed in order to obtain the best torque performance. It is shown that significant reduction of torque ripple is achieved without losing the desired average torque. The influences of the proposed stator design on the back-EMF, output torque and cogging torque are analysed and compared with the initial machine design.

LS PO#: 444431 Rate Confirmation ±LONGSHIP Longship P.O. Box 12307 - Lexington, KY 40582 Phone: (855) 440-2828 Ext: 1156 - Fax: (859) 549-8121 - Email: skeys@longship.us Load Information 12/4/2023 1:06 pm 444431 Trailer: Reefer Delivery Date: Size: 53 ft Temperature: -10 12/06/2023 Weight: 35,000 CONTINUOUS RUN LS PO#: Pick Up Date: 12/05/2023 Miles: 223.61 Carrier Information Carrier: HITCHED LOGISTICS LLC MC: 1185021 Phone: (972) 352-9228 Fax: (214) 330-0414 Driver: DETRIQUE Driver Cell: (469) 655-0023 Dispatcher: DETRIQUE Dispatcher Phone: (469) 655-0023 Estimated Rate (To The Truck): $1,450.00 Rate Description Quantity Total $1,200.00 FLAT 1 $1,200.00 $250.00 LAYOVER 1 $250.00 (Rates based upon weight or count will be calculated from the quantities loaded.) Carrier IS NOT Responsible For Unloading Charges Carrier IS NOT Responsible For Pallet Exchange Pick Ups Shed EAST BAKING COMPANY, INC Physical Address: Deliveries Consignee WALMART DC 8348 Physical Address: City HOPE State Zip Date Time Phone PU Number AR 71801 12/5/2023 6am-2pm 0799696119 2700 E. THIRD STREET Shipping Hours: Weight: Pallet Count: Case/ Piece Count: City LANCASTER 940 E PLEASANT RUN RD Weight: State TX Zip 75146 Temp Date Time Phone -10 12/6/2023 Delivery PO 24174248 Receiving Hours: Pallet Count: Case/ Piece Count: SPECIAL INSTRUCTIONS: MUST HAVE AIR-RIDE, AIR-CHUTE, 2 SETS OF LOAD LOCKS & REEFER MUST BE 2010 OR NEWER. DETENTION IS CASE BY CASE AND DOES NOT APPLY TO FCFS SHIPPERS, FCFS RECIEVERS, OR PRODUCE LOADS. REEFER MUST BE SET ON CONTINUOUS @ ALL TIME. TEMPERATURE IS SPECIFIED ON LOADED BILL OF LADING. IF TEMPERATURE DOESN'T MATCH BOTH BOL AND RATE CONFIRMATION DRIVER MUST NOTIFY BROKER BEFORE LEAVING THE SHIPPER. IF CARRIER IN ANY CAPCITY INCORRECTLY SETS THE TEMPERATURE OR REEFER SETTING, CARRIER TAKES FULL MONETARY RESPONSIBILTIY FOR DAMAGED PRODUCT. UNLOADING/LUMPER RECEIPTS MUST BE SUBMITTED WITH INITIAL POD IN ORDER TO BE REIMBURSED. DRIVER MUST VERIFY COUNTS WHILE LOADING & DISCREPANCIES MUST REPORTED IMMEDIATELY PRIOR TO DEPARTING FROM SHIPPER AND/OR RECEIVER TO AVOID DEDUCTION PENALTIES. CARRIER MUST SCALE AT THE NEAREST SCALE ONCE LEAVING SHIPPER, LONGSHIP WILL NOT PAY FOR EXTRA MILES RAN BY TRUCK FOR MISSED SCALES. DO NOT BREAK SEAL OR LOAD IS CONSIDERED A FULL CLAIM. MUST MAKE ASSIGNED DELIVERY TIME AS STATED ON RATE CONFIRMATION OR LATE FEES COULD APPLY. 1242023130629Page: 2 Rate Confirmation LS PO#: 444431 LONGSHIP RESERVES THE RIGHT TO CROSS-DOCK PRODUCT AT ANY TIME THROUGHOUT TRANSIT. IN THE EVENT OF A REJECTION OF ANY KIND CARRIER IS RESPONSIBLE FOR RE-DELIVERING THE REJECTED PRODUCT AND COMPENSATION WILL BE NEGOTIATED ON A CASE-BY-CASE BASIS AND WILL NOT EXCEED $2/MILE. VENTED VAN LOADS MUST HAVE FRONT AND REAR PRODUCE VENTS. IF THE CARRIER DOES NOT ACCEPT THESE TERMS, CROSS DOCKING/RECOVERY TRUCK FEES WILL BE TAKEN FROM THEIR ORIGINALLY AGREED UPON RATE. POD & UNLOADING/LUMPER RECEIPTS MUST BE TURNED IN WITHIN 24 HOURS OF DELIVERY. EMAIL TO SKEYS@LONGSHIP.US 1. For prompt payment please email all paperwork including BOLs, Lumper receipts, Carrier Invoice, etc. to accounting@longship.us or if originals are required mail them to P.O. Box 12590 Lexington, KY 40583. For Quick Pay please email all paperwork to quickpay@longship.us or upload though the TriumphPay App. 2. 3. 4. 5698 9. This load is subject to all terms and conditions of the Broker- Carrier Agreement and all quick pay fees are subject to change at any time without prior notification. All Drivers are required to check call every day (including Sat., Sun., and holidays), between 8:00am and 9:00 am Eastern Time. Failure to provide timely check calls could result in a penalty against the carriers final settlement. Longship is available 24 hours a day 7 days a week. Failure to call immediately could result in a penalty against the final settlement. Driver must have a minimum of 2 load locks to secure the load. A fee of $7.50 per pallet will be charged on loads that the carrier is responsible to supply pallets for exchange and they do not. If any loads are sealed the driver/carrier cannot break any seal or there will be a claim charged to the carrier. Unless originals are required please FAX or EMAIL BOLS to your LS Crew Member email directly to accounting @longship.us. Once paperwork has been received (whichever comes first via e-mail, fax, or mail), no further adjustments can be made. Unloading receipts must be included with initial submission or they will NOT be reimbursed. 10. Detention is handled on a case by case basis and carrier MUST notify LS Crew Member 1 hour before detention begins to accrue. Note: Detention does not apply to produce loads. Loads delivered late may be subject to late fees. 11. Advances are limited to 40% of the linehaul rate. 12. Longship Full truckload shipments (FTL) may NOT be paired with other Less than truckload (LTL) shipments without written permission from a Longship Crew Member or deductions may apply. If you have any comments or concerns about your experience with Longship, please email us at info@longship.us. Your feedback is very important to us. Thank you for helping us better serve our customers! See Shaun Keys LS REPRESENTATIVE SIGNATURE CARRIER REPRESENTATIVE SIGNATURE Load Summary * IMMEDIATELY FAX A COPY OF THIS SIGNED CONFIRMATION TO (859) 549-8121 Estimated Rate (To The Truck): First Pick: EAST BAKING COMPANY, INC Last Drop: WALMART DC 8348 $1,450.00 2700 E. THIRD STREET 940 E PLEASANT RUN RD HOPE AR 71801 LANCASTER TX 75146 1242023130629

TRAFFIX High Performance | Logistics PAYMENT OPTIONS Instapay by Smart Fleet Funding 12 hours after invoice - 2.99% INSTAPAY PAYMENT INSTRUCTIONS » Email: instapay@smartfleetfunding.com >> Subject: [Instapay - Traffix Load # ...] SUBMISSIONS MUST INCLUDE >> TRAFFIX load confirmation >> Proof of Delivery >> Invoice with Traffix load number Factoring? Considering it? Smart Fleet Funding is the Smartest and Fastest way to get paid. Save 10% Of Your Current Factoring Fee When You Switch! Call or Email today: 888-236-7345 save10@smartfleetfunding.com Hablamos Espa??ol / www.smartfleetfunding.com Submission Instructions: One Invoice/Load per email submission ⚫ Email Subject MUST Read: Traffix Load # 9999999 (Found on the top right-hand corner of Traffix Load Confirmation) Email MUST Include: Your Invoice, TRAFFIX Load Confirmation, Signed Proof of Delivery + supporting receipts and documents Supported formats: PDF, JPEG and TIFF G SMART FLEET FUNDING REGULAR PAYMENT INSTRUCTIONS TRAFFIX RECOGNIZES INVOICE DATE AND PAYMENT AGING AFTER COMPLETE DOCUMENTATION IS RECEIVED Email: carrierpayment@traffix.com Subject: [Regular Traffix Load # ...] Any questions ONLY related to payment, please email AP@traffix.com or Call 855-240-0730Traffix Load #: T00431745 Date Tendered: 11-28-2023 TRAFFIX High Performance Logistics Submit Invoices to: carrierpayment@traffix.com or call 855-240-0730 This Load Confirmation must accompany Invoice Accept/Decline/View Tender Please click this link to Accept a Tender: Click to AcceptPlease click this link to Decline a Tender: Click to DeclinePlease click this link to View a Tender: Click to View CARRIER INFORMATION TRAFFIX CONTACT CARRIER NAME: Moctezuma Trucking Inc CONTACT NAME: Jack Scott CONTACT NAME: Victor Moctezuma PHONE NUMBER: 312 820 5805 MC#:MC116663 EMAIL ADDRESS: jscott@traffix.com EMAIL ADDRESS: moctezumatrucking@outlook.com Cost Type Freight RATE CONFIRMATION INFORMATION Accessorial Desc. Amount Picks / Drops: LOAD SUMMARY 1 Pick(s) 1 Drop(s) $550.00 USD Equipment Required: Partial Dry Van Total USD $550.00 Mode and Service: TL Total Miles: Total Weight: 401.79 Mi 8,000 Lb Total Pallets: 14 Total Pieces: 0 Trailer Length: Service Option: OTR Is Bonded: false NO PU# NEEDED NOTES SHIPPER - PICKUP 1 OF 1SHIPPER NAME: HAMMERHEAD OFF-ROAD SHIPPER ADDRESS: 1200 LAKESIDE PKWAY SUITE#400 Flower Mound, TX 75028 TELEPHONE: CONTACT: Pickup Date: 11-28-2023-11-28-2023 Appt Required N Appointment Time: 09:00 - 15:00 Appt Made N Reference Numbers Items Confirm Receipt Of Commodity Handling Units Unit Type Stackable Pieces Pieces Type Weight DIMS (L x W x H) Temperature GO KARTS 14 Pallet Yes 0 8000 Lb SHIPPER Notes CONSIGNEE - DELIVERY 1 OF 1 Reference Numbers CONSIGNEE NAME: Uvalco Powersports and Equipment CONSIGNEE ADDRESS: 2521 E Main St Uvalde, TX 78801 TELEPHONE: CONTACT: Delivery Date: 11-29-2023-11-29-2023 Appt Required N Appointment Time: 10:00 - 13:00 Appt Made N Items Confirm Receipt Of Commodity Handling Units Unit Type Stackable Pieces Pieces Type Weight DIMS (L x W x H) Temperature GO KARTS 14 Pallet Yes 0 8000 Lb CONSIGNEE NotesTerms and Conditions FAILURE TO COMPLY WITH THESE TERMS & CONDITIONS WILL RESULT IN NON PAYMENT OF INVOICE: 1. CARRIER MUST ADVISE TRAFFIX OF ANY DELAYS OR DISCREPANCY ATLEAST 2 HOURS PRIOR TO PICK UP / DELIVERY APPOINTMENT TIME. MISSED OR LATE APPOINTMENTS MAY BE SUBJECT TO FINES AND/OR CHARGE BACK BY TRAFFIX. 2. DOUBLE BROKERING OF TRAFFIX FREIGHT IS STRICTLY PROHIBITED. TRUCK/TRAILER INFORMATION ON BOL MUST MATCH CARRIER CONFIRMATION. 3. TEAM SERVICE REQUIRES A MINIMUM OF 1000 MILES OF TRAVEL PER 24 HOUR PERIOD. LESS THEN 1000 MILES MAY BE SUBJECT TO FINES AND/OR CHARGE BACK BY TRAFFIX. 4. BACK SOLICITATION WILL RESULT IN LEGAL ACTION AND NON PAYMENT. 5. CARRIER IS RESPONSIBLE FOR ALL LOADING AND UNLOADING CHARGES. 6. CARRIER MUST PULP ALL PRODUCT DURING LOADING AND ENSURE TEMPERATURE MATCHES THEIR BILL OF LADING AND LOAD CONTRACT. DISCREPENCY MUST BE REPORTED TO TRAFFIX DISPATCH IMMEDAITELY AND MUST BE APPROVED BY TRAFFIX PRIOR TO DEPARTURE FROM SHIPPER. 7. CARRIER AGREES THAT THIS CONTRACT IS LIMITED TO THE CARRIER BROKER RELATIONSHIP AND ALSO AGREES TO HOLD THE SHIPPER, CONSIGNEE, AND OTHER BENEFICIAL PARTIES HARMLESS AGAINST ANY DISPUTES ARISING FROM PAYMENT OR SERVICE. 8. ANY ADDITIONAL CHARGES MUST BE APPROVED BY TRAFFIX PRIOR TO INVOICING. CARRIER MUST OBTAIN A REVISED LOAD CONTRACT FROM TRAFFIX DISPATCH FOR THE EXPENSE TO BE PROCESSED. 9. CARRIER IS RESPONSIBLE FOR ALL ASSOCIATED BOND CHARGES AND FINES. PROOF OF BOND CANCELLATION MUST BE PRESENTED FOR PAYMENT. 10. CLAIMS AND DAMAGES WILL BE HELD AGAINST CARRIER ACCOUNT IN ARREARS UNTIL THE CLAIM IS SETTLED. TRAFFIX SHALL HAVE ALL THE RIGHTS AND REMEDIES OF CARRIER UNDER CANADIAN AND UNITED STATES LAW TO PURSUE THE CONSIGNEE/BENEFICIAL RECIPIENT FOR UNPAID FREIGHT IN THE EVENT THAT THE CARRIER HAS BEEN PAID FOR THE LOAD BUT TRAFFIX HAS NOT. 11. ORIGINAL SIGNED PROOF OF DELIVER, CUSTOMS CLEARANCE, AND TRAFFIX LOAD CONTRACT ALL REQUIRED FOR INVOICE SUBMISSION. ALL CARRIER DOCUMENTATION SHOULD BE SUBMITTED TO CARRIERPAYMENT@TRAFFIX.COM WITHIN 72 HOURS OF DELIVERY. IF CARRIER DOCUMENTATION IS RECEIVED MORE THAN 60 DAYS AFTER LOAD HAS DELIVERED, CARRIER WILL HAVE TO GO THROUGH AN APPEAL PROCESS TO BE PAID ON LOAD 12. JURISDICTION WILL BE DETERMINED BY THE TRAFFIX BILL-TO: CITY / STATE (PROVINCE) AS REFERENCED IN THIS CONTRACT. 13. FUEL ADVANCES OF 40% ARE CHARGED A FEE OF 5% OF THE REQUESTED ADVANCE AMOUNT. 14. IF DETENTION OCCURRED, TIMES MUST BE STAMPED AND SIGNED BY PICKUP AND/OR DELIVERY FACILITY IN ORDER TO BE PAID. CARRIER IS ALSO REQUIRED TO NOTIFY TRAFFIX PRIOR TO DETENTION OCCURRING TO ASSIST WITH THE LOADING/UNLOADING PROCESS. 15. IF LUMPER OCCURRED AT DELIVERY, CARRIER MUST NOTIFY TRAFFIX OF AMOUNT PAID & SUBMIT RECEIPT WITHIN 48 BUSINESS HOURS OF DELIVERY OR LUMPER WILL NOT BE REIMBURSED. 16. SEAL MUST REMAIN INTACT AT ALL TIMES AND MAY NOT BE BROKEN WITHOUT CONSENT FROM TRAFFIX. IN THE EVENT THAT A SEAL IS BROKEN BY CANADIAN BORDER SERVICES OR UNITED STATES CUSTOMS & BORDER PROTECTIONS, PLEASE ADVISE TRAFFIX IMMEDIATELY WITH THE NEW SEAL INFORMATION. ANY SEAL BROKEN BY THE CARRIER WILL RESULT IN AN INSURANCE CLAIM FOR THE FULL VALUE OF THE PRODUCT ONBOARD. The link provided below contains important information regarding the FDAs new regulations for the transportation of food for human and animal consumption. As a carrier you are responsible for meeting the regulations that are outlined in the attached documents. Please go the attached link and read the documents. https://traffix.com/media/download/68 Accept/Decline/View Tender Please click this link to Accept a Tender: Click to AcceptPlease click this link to Decline a Tender: Click to DeclinePlease click this link to View a Tender: Click to View

7701 Metropolis Dr | Bldg 15 Austin, TX 78744 Phone: (888) 861-0650 | Fax: (512) 872-5109 ARRIVE Have your driver call in for dispatch at (888) 861-0650 ext. 1 and reference the Arrive order LOGISTICS 2882135 Carrier Truck Carrier E&g Ac Inc Equipment Van Attn Food Grade Required Phone Straps Needed Required Truck Number Driver Driver Phone Load Arrive Order Cargo Value Total Miles Total Pieces Total Weight Load Type Load EQ Type EQ Size Shipment ID PO # 2882135 $100,000.00 544 Miles 720 Pieces 41240 lbs Dry Van or Reefer 53 ft 64174914 25586940010 Fax BOL # Rate Details LineHaul Total 2604710569 $1,400.00 $1,400.00 HOW TO GET PAID! All invoices must be emailed to invoices@arrivelogistics.com DOCUMENTS NEEDED • Carrier invoice All pages of the signed Proof of Delivery (POD) Rate confirmation All approved accessorial documents and receipts previously approved by your sales rep PAYMENT TERMS Default payment terms are Net 30 from the date all required documents are received. You can select standard terms or our QuickPay option of Net-2 for a 2% fee, through TriumphPay. GETTING STARTED ON TriumphPay Visit https://secure.triumphpay.com/ to create an account with TriumphPay or if you already have a TriumphPay account, enter your login information. Once logged in, select Arrive Logistics as your broker and confirm the relationship through authentication. ⚫ Select your preferred payment term, your payment type, and verify your carrier information.A 7701 Metropolis Dr | Bldg 15 Austin, TX 78744 Phone: (888) 861-0650 | Fax: (512) 872-5109 ARRIVE Have your driver call in for dispatch at (888) 861-0650 ext. 1 and reference the Arrive order LOGISTICS 2882135 Pickup #1 Pickup Address Appointment Ref/PO# Commodity Weight Reference # 2217817930 May 12, 2022 NONHAZ LUBRCIANTS 720 PIECES 41240 lb Baton Rouge, LA 70802 08:00 CDT WILSON WAREHOUSE 2400 SORREL AVENUE Appt. Type By Appointment Confirmed Driver Instructions: BY APPOINTMENT Pickup Notes: C OF A (&) MSDS WITH SHIPMENT BUYER CONTACT - TANAY MOULDER @ 404 714 9014 TAN AY.MOULDER@DELTA.COM CUSTOMER SERVICE - AVIATIONAMERICAS@CONTACTEXXONMOBIL.COM C OF A (&) MSDS WITH SHIPMENT BUYER CONTACT - TANAY MOULDER @ 404 714 9014 TANA Y.MOULDER@DELTA.COM CUSTOMER SERVICE - AVIATIONAMERICAS@CONTACTEXXONMOBIL.COM Delivery #1 Delivery Address DELTA AIR LINES -ATLANTA 1 5169 PELICAN DR Atlanta, GA 30349 4045990465 Appointment Ref/PO# Reference # Commodity Weight 2217817930 Earliest Date/Time NONHAZ LUBRCIANTS 720 PIECES 41240 lb May 12, 2022 00:01 EDT Latest Date/Time May 12, 2022 23:59 EDT Appt. Type FCFS Confirmed Driver Instructions: FCFS APPOINTMENT. Delivery Notes: C OF A (&) MSDS WITH SHIPMENT BUYER CONTACT - TANAY MOULDER @ 404 714 9014 TAN AY.MOULDER@DELTA.COM CUSTOMER SERVICE - AVIATIONAMERICAS@CONTACTEXXONMOBIL.COM C OF A (&) MSDS WITH SHIPMENT BUYER CONTACT - TANAY MOULDER @ 404 714 9014 TANA Y.MOULDER@DELTA.COM CUSTOMER SERVICE - AVIATIONAMERICAS@CONTACTEXXONMOBIL.COM Load Comments PLEASE READ ALL COMMENTS **MAKE SURE TO CHECK BOL TO ENSURE INFO MATCHES RATE CON. PLEASE REACH OUT IMMEDIATELY IF THERE ARE DIFFERENCES** **MUST HAVE PROJECT44/MACROPOINT/TRUCKER TOOLS - NO EXCEPTIONS Possible carrier fines for not setting up auto tracking Please make sure the driver has a smartphone if you are using Trucker Tools for auto-tracking. **CONFIRM HOW MANY HOURS THE DRIVER HAS AVAILABLE PRIOR TO TAKING THE LOAD Lumper Comments Detention CommentsAll invoices must include signed proof of delivery and supporting documents. Please email to invoices@arrivelogistics.com or send to: Arrive Logistics, LLC 7701 Metropolis Dr | Bldg 15 Austin, TX 78744 PH# (888) 861-0650 FAX (512) 872-51097701 Metropolis Dr | Bldg 15 Austin, TX 78744 A ARRIVE Phone: (888) 861-0650 | Fax: (512) 872-5109 Have your driver call in for dispatch at (888) 861-0650 ext. 1 and reference the Arrive order LOGISTICS 2882135 All trailers must be absolutely free of all debris of any kind or will be turned away and refused loading. Reasons to reject trailer at loading include, but are not limited to the following: Foul Odors, Broken glass, Metal shavings, Infestation, and mold. Load locks or 2 straps or a combination of these two options - Mandatory for each load. Drivers will be turned away if noncompliant. All drivers must arrive 15 minutes prior to their scheduled pick up time at this location. You will be considered late if you arrive less than 15 minutes prior to your pickup appointment. Drivers must confirm trailer seal on correct trailer door prior to departure Operational Rules: 1. If a driver is not permitted to confirm (by visual inspection) that the load is secure and the piece count is correct. The driver is required to call Arrive immediately and have this information documented on the BOL with the words - Shipper Load/Count per Shipper Signature / Initials. Communication to Arrive must take place PRIOR to the driver leaving the facility. 2. Do not dispatch a driver who cannot meet transit time without violating Hours of Service or other safety rules. Nothing in this Rate Confirmation constitutes a request to violate Hours of Service or other safety rules or to coerce a driver to do so. 3. This Rate Confirmation is deemed accepted by Carrier unless it is rejected within 48 hours of receipt. 4. Receipt of shipment by Carrier constitutes acceptance of and agreement to the terms of this Rate Confirmation. 5. Double brokering without prior written authorization will result in forfeiture of payment by Arrive to Carrier. 6. Any communication regarding this load must be addressed to Arrive and not its customer. 7. All charges are included in this Rate Confirmation. 8. Carrier must give Arrive notice 1 Hour prior to detention occurring. 9. Carrier agrees in the event there are overages, shortages, or damages, Carrier will contact Arrive◆s office to report the discrepancy before leaving the customer◆s premises. 10. Payment will be made within thirty (30) days after receipt of invoice, original BOL, and signed Load-Rate Confirmation unless Arrive disputes the invoice or any part thereof. 11. Freight must not be handled or trans loaded by Carrier without approval from Arrive. In the event of Carrier◆s violation of this Operational Rule, the limitation of liability as to cargo loss or damage set forth in the Broker Carrier Agreement between Arrive and Carrier shall be voided and payment by Arrive to Carrier shall be forfeited by Carrier. 12. Carrier or its agent certifies that any Transportation Refrigeration Unit (TRU or reefer) equipment furnished will be in compliance with the in-use requirements of the California TRU regulations. 13. This Rate Confirmation incorporates the terms and conditions of a Broker Carrier Agreement signed by Arrive and Carrier. 14. In the event of a conflict between this Rate Confirmation and any Broker Carrier Agreement between Arrive and Carrier, this Load-Rate Confirmation shall govern as to the provisions in conflict. If this load is a temp-controlled load follow these guidelines: 1. All temp-controlled loads should be run on continuous. 2. The temperature must follow the Bill Of Lading. - If no temperature, please call Arrive immediately. - If there are any discrepancies in the Arrive Rate Confirmation and BOL - Please call Arrive immediately. Temp on BOL will prevail. Do not dispatch a driver who cannot meet transit time without violating Hours of Service or other safety rules. Nothing in this Rate Confirmation constitutes a request to violate Hours of Service or other safety rules or to coerce a driver to do so. Broker. Arrive Logistics, LLC Carrier Signature: Print Name: Driver: Truck#: Tllr: _Cell #: Tllr. Type: A Rate Confirmation from Arrive Logistics will only be sent from the following email addresses: @arrivelogistics.com @arrivefresh.com @arvy.us. It is the Carriers responsibility to verify that a Rate Confirmation has come from a legitimate Arrive email prior to accepting a load and performing services; Arrive will not be held responsible for any payments, losses or damages incurred by Carrier or any third party associated with a Rate Confirmation that has not legitimately originated from Arrive. NOTE:By accepting this Rate Confirmation, Carrier warrants and agrees that it will follow all rules and regulations concerning its choice of driver(s), including assigning a driver who can perform the transportation services without violating the Hours of Service of Drivers Regulations contained in 49 CFR 395 applicable at the time of acceptance of the shipment.

Penconazole is a widely used fungicide in the UK; however, to date, there have been no peer-reviewed publications reporting human metabolism, excretion or biological monitoring data. The objectives of this study were to i) develop a robust analytical method, ii) determine biomarker levels in volunteers exposed to penconazole, and, finally, to iii) measure the metabolites in samples collected as part of a large investigation of rural residents' exposure. An LC-MS/MS method was developed for penconazole and two oxidative metabolites. Three volunteers received a single oral dose of 0.03 mg/kg body weight and timed urine samples were collected and analysed. The volunteer study demonstrated that both penconazole-OH and penconazole-COOH are excreted in humans following an oral dose and are viable biomarkers. Excretion is rapid with a half-life of less than four hours. Mean recovery of the administered dose was 47% (range 33%-54%) in urine treated with glucuronidase to hydrolyse any conjugates. The results from the residents' study showed that levels of penconazole-COOH in this population were low with >80% below the limit of detection. Future sampling strategies that include both end of exposure and next day urine samples, as well as contextual data about the route and time of exposure, are recommended.

Medical additive manufacturing requires standard tessellation language (STL) models. Such models are commonly derived from computed tomography (CT) images using thresholding. Threshold selection can be performed manually or automatically. The aim of this study was to assess the impact of manual and default threshold selection on the reliability and accuracy of skull STL models using different CT technologies. One female and one male human cadaver head were imaged using multi-detector row CT, dual-energy CT, and two cone-beam CT scanners. Four medical engineers manually thresholded the bony structures on all CT images. The lowest and highest selected mean threshold values and the default threshold value were used to generate skull STL models. Geometric variations between all manually thresholded STL models were calculated. Furthermore, in order to calculate the accuracy of the manually and default thresholded STL models, all STL models were superimposed on an optical scan of the dry female and male skulls (gold standard). The intra- and inter-observer variability of the manual threshold selection was good (intra-class correlation coefficients >0.9). All engineers selected grey values closer to soft tissue to compensate for bone voids. Geometric variations between the manually thresholded STL models were 0.13 mm (multi-detector row CT), 0.59 mm (dual-energy CT), and 0.55 mm (cone-beam CT). All STL models demonstrated inaccuracies ranging from -0.8 to +1.1 mm (multi-detector row CT), -0.7 to +2.0 mm (dual-energy CT), and -2.3 to +4.8 mm (cone-beam CT). This study demonstrates that manual threshold selection results in better STL models than default thresholding. The use of dual-energy CT and cone-beam CT technology in its present form does not deliver reliable or accurate STL models for medical additive manufacturing. New approaches are required that are based on pattern recognition and machine learning algorithms.

The availability of visual sensors and the increment of their processing capabilities have led to the development of a new generation of multi-camera systems. This increment has also conveyed new expectations and requirements that cannot be fulfilled by applying traditional fusion techniques. The ultimate objective of computer vision systems is to obtain a description of the observed scenario in terms that are both computable and human-readable, which can be seen as a specific form of situation assessment. Particularly, there is a great interest in human activity recognition in several areas such as surveillance and ambient intelligence. Simple activities can be recognized by applying pattern recognition algorithms on sensor data. However, identification of complex activities requires the development of cognitive capabilities close to human understanding. Several recent proposals combine numerical techniques and a symbolic model that represents context-dependent, background and common-sense knowledge relevant to the task. In this chapter the current challenges in the development of vision-based activity recognition systems are described, and how they can be tackled by exploiting formally represented context knowledge. Along with a review of the related literature, we describe an approach with examples in the areas of ambient intelligence and indoor security. The chapter surveys methods for context management in the literature that use symbolic knowledge models to represent and reason with context. Due to their relevance, we will pay special attention to ontology and logic-based models.

C.H. Robinson Contract Addendum and Carrier Load Confirmation - Page 1 of 3 #400037817 This load confirmation is confidential information of CH Robinson and may not be disclosed to third parties without CH Robinson's prior written approval. General Contact at JY PRADO TRANSPORT CORP - T6097099 C.H. Robinson requires automated shipment check-in and in-transit updates from one of the approved shipment status technologies. Additional information about these technologies can be found at www.chrobinson.com. If you require assistance during your check-in process, please use one of our mobile apps, or call (888) 278-9441. CARRIER DRIVER Download on the GET IT ON App Store Google Play C.H. Robinson Communication This load was booked with Austin Patella, (866) 281-6676 x5115, PATEAUS@chrobinson.com. Equipment: Temp Control: Reefer - Customer-Specified Equipment Requirements Min L=53 Min/Max Temp: -10/0 - Continuous C.H. Robinson's Customer requires that the Carrier arrives at Shipper with the following specific equipment to properly transport this shipment: A food-grade trailer is required for this shipment. Customer Requirements Carrier shall ensure that this shipment will not be left unattended for any period of time and that a Carrier representative will secure the shipment against theft at all times until delivered. **FOR MCLANES DELIVERIES ONLY**Failure to call CH Robinson during business hours or call McLanes facilities directly afterhours and notify the respective party prior to missing a delivery appointment coud result in fines up to $500 per PO. ***DETENTION BEGINS AFTER 3 HOURS*** -FOOD GRADE TRAILER REQUIRED -SEAL MAY ONLY BE BROKEN BY CONSIIGNEE OR CONSIGNEEE'S LEGAL AGENT SHIPPER#1: Address: US COLD STORAGE (MCDONOUGH) 1420 Greenwood Rd. Mcdonough, GA 30253 Pick Up Date: *Scheduled to Pick* Pick Up Time: Pickup #: Appointment #: 06/06/22 12:30 Appt. -80302947 04636 Phone: (678) 554-2653 Please ask for and confirm receipt of: Commodity Food Product Est Wgt 14,912 Units Pieces(s) Count 302 Pallets 10 Temp -10-0 °F Ref # Shipper Instructions FOOD GRADE TRAILER REQUIRED; MUST BE CLEAN, NO HOLES, NO ODORS, NO DEBRIS RECEIVER #1: Address: Costco West Palm Beach Depot # 280 5851 45th Street WEST PALM BEACH, FL 33407 Phone: (561) 273-2520 Please confirm delivery of: Commodity Food Product Receiver Instructions Delivery Date: 06/07/22 *Scheduled Delivery* Delivery Time: Delivery#: 07:30 Appt. 002800523224 Appointment#: Est Wgt 14,912 Units Pieces(s) Count 302 Pallets Temp Ref # 10 -10-0 °FPage 2 of 3 C.H. Robinson Contract Addendum and Carrier Load Confirmation - #400037817 Service for Load #400037817 Line Haul - FLAT RATE Total: Rate Details Amount 1 Rate $1,820.00 Extended $1,820.00 $1,820.00 SUBMIT FREIGHT BILL TO: CHRW Billing P.O. Box 3470 Chicago, IL 60654 LoadDocs@CHRobinson.com To insure prompt payment, all billing must be accompanied by an invoice with the Carrier Name and C.H. Robinson Load Number Fuel Surcharge Information Please note that C.H. Robinson has included a $398.16 fuel surcharge within the listed transportation rate on this confirmation. The fuel surcharge is an estimate based off of a weekly national average fuel price from the U.S. Department of Energy. QUICK PAY and CASH ADVANCE QUICK PAY - If you are a Carrier who utilizes C.H. Robinson's Quick Pay Program, you may email your invoice and required paperwork to LoadDocs@chrobinson.com or visit NavisphereCarrier.com for other scanning options. Funds will be released from C.H. Robinson, minus the fixed discount, within two business days from receipt of complete and legible paperwork. Paperwork received by 12:00 noon (CST) will be counted as same day; paperwork received after 12:00 noon (CST) will count as the next business day. Carriers enrolled in Quick Pay are no longer required to submit original paperwork for payment in addition to using one of our billing methods unless otherwise instructed by C.H. Robinson. Carrier shall retain custody of the original paperwork and provide it to C.H. Robinson upon Request. C.H. Robinson also recommends that Carrier only submit "receipt" for payment once, regardless of billing method to avoid additional fees. If you would like more information about becoming enrolled in Quick Pay, please contact the Quick Pay Department at (800) 326-9977. For a list of our billing options, please visit NavisphereCarrier.com. CASH ADVANCE - Carriers may request a cash advance from C.H. Robinson to be issued at C.H. Robinson's sole discretion as a partial settlement to the agreed upon rate. All cash advances will be deducted from final settlement; including a transaction fee of the greater of 3% of the advance issued or $15 for each individual advance. Directions Any directions given by C.H. Robinson or its Customers, whether orally and/or electronically, are for informational purposes only. It is the Carrier's sole responsibility to confirm that it may lawfully and safely operate its vehicle and its contents over any road, highway, bridge and/or route. Carrier shall be solely responsible for any fines, penalties, or citations that may be levied as a result of operating its vehicle equipment and its contents in any way that may be found to be in violation of any regulation, law or ordinance. Receiver's Driving Directions RECEIVER 1 - Costco West Palm Beach Depot # 280: Go South on 95 to exit 74. Go west off the exit (which will be 45th street) go for abotu 2 miles and Costco will be on the right hand side.C.H. Robinson Contract Addendum and Carrier Load Confirmation - Page 3 of 3 #400037817 C.H. Robinson Contract Addendum and Carrier Load Confirmation Conditions THIS LOAD CONFIRMATION IS SUBJECT TO THE TERMS OF THE AGREEMENT FOR MOTOR CONTRACT CARRIER SERVICES ("AGREEMENT") PREVIOUSLY EXECUTED BETWEEN OUR COMPANIES AND THIS CONSTITUTES AN ADDENDUM TO THE TERMS OF THAT AGREEMENT. WE AGREE TO PAY THE RATES AND CHARGES SHOWN ABOVE AND NO DIFFERENT TARIFF RATE OR SCHEDULE OF RATES APPLY. THIS LOAD CONFIRMATION IS INCLUSIVE OF ALL CHARGES. UNLESS ORAL AND WRITTEN FAX OBJECTIONS ARE MADE TO ITS TERMS, AT THE EARLIER OF WITHIN TWENTY-FOURS (24) HOURS OF RECEIPT OR PRIOR TO WORK BEING INITIATED, YOU HAVE AGREED TO THESE TERMS. Additional Terms 1. Unless C.H. Robinson provides written notice herein that this term does not apply to this shipment, Carrier's motor vehicle equipment shall be dedicated to C.H. Robinson's exclusive use while transporting the cargo subject to this booking. Carrier's violation of this exclusive use requirement shall result in Carrier's forfeiting its right to be paid for the transportation services contemplated by this Load Confirmation, not as penalty, but as liquidated damages. 2. Cash advance requests made after regular business hours will not be authorized. If Carrier requires a cash advance, Carrier must make arrangements with the C.H. Robinson booking representative during normal business hours and/or upon booking this shipment. Cash advance requests made outside of the C.H. Robinson booking branch's regular business hours may not be authorized. If Carrier requires a cash advance, Carrier must make arrangements with the C.H. Robinson booking branch during its normal business hours and/or upon booking this shipment. 3. This rate is contingent upon successful and on-time completion of all load requirements as orally stipulated or written on this Addendum and rate may be subject to reduction if Carrier fails to complete any applicable terms and conditions. Rate may be reduced if load picks up or delivers after originally scheduled time and date. Carrier acknowledges that failure to complete any terms and conditions on this shipment may jeopardize or result in loss of future business opportunities with C.H. Robinson and/or cancelation of the Agreement. 4. Accessorial charges (including but not limited to labor, detention, and/or layover charges) must be authorized and approved prior to or at time of occurrence. C.H. Robinson will not provide any reimbursement of any non, prior-approved accessorial charges. Carrier shall ensure the bill of lading is notated either when handling is required or when detention occurs, that a lumper receipt is provided when a lumper is hired, and/or that both are included as supporting documents with the Carrier's invoice. All overage, shortage, and damage must be reported to C.H. Robinson immediately, at time of occurrence, and noted on the bill of lading. 5. C.H. Robinson's Customer requires that Carrier provide, through C.H. Robinson, the following electronic shipment status updates via EDI, NavisphereCarrier, the Navisphere driver app, or some other electronic method of providing shipment status updates (unless otherwise specified on this confirmation): - Arrival at and departure from Shipper(s) within thirty (30) minutes of occurrence; - A minimum of one check call per day, prior to 10:00am, each day that Carrier is in possession of this shipment; and - Arrival at and departure from Receiver(s) within thirty (30) minutes of occurrence. 6. For any problems or issues after regular business hours or over the weekends, please contact C.H. Robinson at . 7. For this shipment, Carrier agrees it shall be in possession of relevant and applicable cargo insurance coverage in an amount sufficient to cover the loss or damage of the cargo being transported. Carrier's cargo insurance policy must not exclude from coverage any commodities or cargo carried on this booking. If Carrier's cargo insurance policy contains a schedule of covered vehicles or equipment, Carrier will not transport any cargo on this booking using a vehicle and/or equipment that is not listed as scheduled on Carrier's cargo insurance policy.

Objective. NSAIDs are first-line therapy in axial SpA (axSpA). The proportion of patients responding to NSAIDs and differences between AS and non-radiographic axSpA (nr-axSpA) in this regard have not been studied in detail to date. The aim of this study was to examine the proportion of patients with AS and nr-axSpA responding to NSAIDs according to current treatment recommendations. Methods. Consecutive anti-TNF-naive patients with nr-axSpA and AS (n = 50 each) were included if their BASDAI score was 54 without having received maximal NSAID doses. In case of a BASDAI score 54 1 week later, another NSAID was prescribed. For the next 3 weeks, continuous intake of maximal doses was recommended but patients could reduce doses in case of intolerance or improvement. MRI of the SI joints was performed at baseline and week 4. Results. All outcomes except for CRP and MRI scores improved significantly after 4 weeks of NSAIDs, with no difference between axSpA subgroups. An Assessment of SpondyloArthritis international Society 40% (ASAS40) response and partial remission rates were 35 and 16% at week 4, respectively. At the same time point, a BASDAI score >= 4 was still present in 44% of patients, 30% of which had reduced NSAID doses, partly due to intolerance (38%). Only 13% of all patients had continuously taken NSAIDs at the maximal dosage, but there was no difference in the efficacy outcome compared with those who had taken reduced doses. Conclusion. AS and nr-axSpA patients had similar response rates to NSAIDs while objective signs of inflammation did not change over 4 weeks. Only a minority of patients was willing to take maximal doses of NSAIDs, and >= 40% patients remained candidates for TNF blockers. These results may influence future trial designs.

In 2012 the 36,5 km long section of the expressway S7 between the Polish villages Paslek and Milomlyn was completed. The road alignment partially crossed up to 11 m thick organic soil formations showing a consistency in the range of plastic to soft plastic. Therefore subsoil improvement measures such as unreinforced full displacement concrete piles and a geotextile reinforced embankment were designed by the owner. Despite the executed soil improvement measures only seven months after the release for traffic settlements up to 70 cm occurred along a 35 m long section of the expressway. Utilizing 2D Finite Element Method as well as comparative calculations using conventional methods a failure back analysis was conducted by Zentrale Technik - Technical Office Vienna. The article at hand focusses on the executed assessment of damage as well as on the results of the performed failure analyses and furthermore the elaborated restoring concepts and the restoring measure executed on site are presented.

Dedicated Logistical Services, Inc PO Box 1750 Collierville, TN 38027 MC# 293646 ES Dispatcher Dispatcher: Phone: Fax: GARY MAYO 800-685-1619 x323 901-861-0459 FDLS Load and Rate Confirmation Agreement Load #472726 Emergency Phone: 800-685-1619 To accept load please sign and email this sheet back to: gsmayo@dlslogistics.com Carrier Information Carrier Number: Load Number: MC Number: Carrier Name: Attention: To: Confirmation Sent 472726 18943 1089430 E&g Ac Inc GSMAYO@DLSLOGISTICS.COM Load Information Commodity: FILES Load Size: Miles: Truckload 453.00 #1 Shipper Driver Name: Truck Number: Trailer Number: Carrier Phone: Carrier Fax: 7868311097 Pickup Number: Trailer Req: Weight: VLD-016 Van 40,000 Tuesday, 03/29/2022 from 08:00 - 15:00 Company: Address: City/St/Zip: VRC Phone: 229-241-8895 100 AVENUE B VALDOSTA, GA 31601 #2 Consignee/Final Destination Company: VRC-FLORENCE Wednesday, 03/30/2022 from 08:00 - 15:00 Phone: 256-768-0640 Address: 3215 ROBERSON ROAD City/St/Zip: FLORENCE, AL 35630 Special Load Requirements: DRIVER MUST CALL FOR DISPATCH. THIS SHIPMENT WILL BE PICKED UP, TRANSPORTED AND DELIVERED BY THE SAID NAMED CARRIER. THIS SHIPMENT WILL NOT BE RE-BROKERED, TRIP LEASED, OR BLIND SHIPPED. DLS RESERVES THE RIGHT TO PAY ACTUAL CARRIERS. • Carrier May be charged for missed or late pick ups or deliveries. CARRIER acknowledges that BROKER should not be listed on the bill of lading and that if BROKER is listed on the Bill of Lading as the carrier this will occur for the convenience of the shipper only and CARRIER at all times is the actual carrier of goods and BROKER'S role is limited to arranging for transportation. In the event BROKER'S name is listed on the bill of lading, shipping manifest or other similar document, as the carrier, CARRIER shall cross-out or otherwise remove BROKER'S name and enter CARRIER'S name as applicable. Confirmation must be signed and faxed to DLS Logistics, Inc. before loading. Driver must seal trailer with shipper signing as a witness, consignee must witness seal being broken or driver will be responsible for the count. The following must be signed and returned for payment: W9, Carrier Broker Contract, signed POD, Contract Authority, Cargo Insurance in DLS name and DLS Pro # on invoice for payment. Amount to invoice: $1,300.00 Carrier: E&g Ac Inc MC #: 1089430 Invoicing Methods 1. Email: billing@dlslogistics.com

Fine-grained image recognition, a computer vision task filled with challenges due to its imperceptible inter-class variance and large intra-class variance, has been drawing increasing attention. While manual annotation can be utilized to effectively enhance performance in this task, it is extremely time-consuming and expensive. Recently, Convolutional Neural Networks (CNN) achieved state-of-the-art performance in image classification. We propose a fine-grained image recognition framework by exploiting CNN as the raw feature extractor along with several effective methods including a feature encoding method, a feature weighting method, and a strategy to better incorporate information from multi-scale images to further improve recognition ability. Besides, we investigate two dimension reduction methods and successfully merge them to our framework to compact the final image representation. Based on the discriminative and compact framework, we achieved the state-of-the-art performance in terms of classification accuracy on several fine-grained image recognition benchmarks based on weekly supervision.

COYOTE Rate Confirmation Send invoices to: Load 26843519 Cust Requirements Equipment Booked By Van, 53' Dan Mullenix Pre Cooled Temp None Load Temp Tarps Value None Undefined $100,000 CarrierInvoices@coyote.com 960 Northpoint Parkway Suite 150 Alpharetta, GA 30005 dan.mullenix@coyote.com Phone: +1 (773) 365 6622 X7629 Fax: +1 (773) 365 4622 T Load Requirements Seal Equipment Requirements N/A Get • Dispatch 877-6COYOTE (877-626-9683) CoyoteGO Today! . Send updates • Check in • Submit paperwork Available for An- droid or iPhone, at App Store or Google Play Notes All Van/Container loads MUST be sealed at origin either by shipper or driver with a seal number noted on bill of lading. The driver is responsible for re-sealing the trailer after each pickup/drop on a multi-stop shipment. In the event a shipment that was sealed at origin or after each additional pickup/drop arrives at the destination with a tampered seal or without the seal intact then (i) the Carrier shall be liable for any shortage or damage claims with respect to such shipment and (ii) the shipper shall have the right, in its sole discretion, to deem the entire shipment damaged, adulterated/contaminated and unsalvageable, without the need for any inspection and the Carrier shall be liable for the full value of the shipment. Carrier is required to weigh shipment within 50 miles of departing each shipper. If carrier fails to weigh shipment within 50 miles of departing each shipper, any citations/expenses incurred due to the equipment and/or shipment weight will be the carrier's sole responsibility. Carrier must meet and comply to shipper requirements at the facility. All drivers must wear masks or facial coverings to the extent required by laws or facilities. Carrier must be in full compliance with the Food Safety Modernization Act (FSMA), if applicable. By accepting the shipment, Carrier agrees that the driver has consented to receiving text messages and/or phone calls from or on behalf of Coyote. Approval for payment of detention is contingent upon the following eligibility requirements: 1) Carrier must report facility departure time and total detention hours within 24 hours of shipment delivery at the final facility. 2) Carrier must provide proof of the on time arrival and departure times in the form of a BOL or other shipping document with arrival and departure times notated by facility within 24 hours of shipment delivery at final facility. thank you Route Directions Carrier acknowledges that any routing instructions from the shipper herein are being provided for convenience only, and the Carrier may choose the route. Signature Line By signing below, J&A TRANSPORT agrees to the terms and conditions set forth below and provided herewith, if any. [Load Number - 26843519] [Carrier Legal Name - JOSE CRUZ CAMPOS CRISPIN] [Carrier USDOT - 3514818] Page 1 of 4COYOTE Rate Confirmation Stop 1: Pick Up Pick Up 9360525358; Numbers 9360524492 Confirmation None Numbers Facility Costco Packaging #910 Address 2222 Enrico Fermi Drive San Diego, CA 92154 Appointment Scheduled For Tue 05/31/2022 at 16:30 Driver Work No Touch SLIC N/A Load 26843519 Facility Notes No liftgate trailers can be used. Driver is responsible for confirming correct PO/PU numbers & that pieces/pallets match on BOL. Trailers must be clean, dry, with no holes/odor. Weight may not include pallet-weight (45-60lbs per pallet). No liftgate trailers can be used. Contact Chris Phone +1 (619) 205 3410 Stop 1 Requirements N/A Commodity PO # Exp Wt Pieces SB VIA COLOMBIA 213CT STARBUCKS SL150 P280 9360525358 5,324 Lbs 22 KS VRTY SNACK NUT 3016Z 30X45G 136KG P175 9360524492 3,061 Lbs 4 Total Stop 2: Delivery Delivery 9360524492; Numbers 9360525358; 932087014634239 Confirmation None Numbers Facility Costco Tolleson - 936 Appointment Scheduled For Wed 06/01/2022 at 12:00 Driver Work No Touch Address 8400 West Sherman Tolleson, AZ 85353 SLIC N/A Contact None Phone +1 (623) 293 1100 Stop 2 Requirements 8,385 Lbs Facility Notes Lumper Receipt Required Within 96 Hours Paperwork Required Within 48 Hours Commodity KS VRTY SNACK NUT 3016Z 30X45G 136KG P175 PO # 9360524492 Exp Wt Pieces 3,061 Lbs 4 SB VIA COLOMBIA 213CT STARBUCKS SL150 P280 9360525358 5,324 Lbs 22 22 Total 8,385 Lbs Directions are provided for convenience only. The Carrier may choose the route. [Load Number - 26843519] [Carrier Legal Name - JOSE CRUZ CAMPOS CRISPIN] [Carrier USDOT - 3514818] Page 2 of 4COYOTE Rate Confirmation From Los Angeles, CA: Load 26843519 I-10 east to exit 135 for 83rd ave 83rd Ave turn right. Go Sherman turn right. I-17 South to the I-17/ I-10 split, get on I-10 west, to exit 135, which is 83rd ave, make a left, take 83rd past the trax, take a right on Sherman (1st street after trax) you will run into the gaurd booth. Carriers may also call 877-6-COYOTE for directions if needed. Charges Description Fuel Surcharge Flat Rate Total Contact Units Per 343.00 $0.830 1.00 Amount Send invoices to: $284.69 Please contact Coyote 960 Northpoint Parkway Suite 150 at 877-626-9683 if the charges are incorrect. $1,115.310 $1,115.31 Alpharetta, GA 30005 USD $1,400.00 Agreement Carrier JOSE CRUZ CAMPOS CRISPIN USDOT 3514818 Phone +1 (909) 685 1862 Email erick@smarthop.com Fax None Broker Coyote Logistics, LLC Rep Dan Mullenix Title Manager Phone +1 (773) 365 6622 x7629 Fax +1 (773) 365 4622 Date 05/27/2022 10:26 By signing below, J&A TRANSPORT agrees to the terms and conditions set forth below and provided herewith, if any. Name and Title (Print) Signature Date PLEASE SIGN THIS AGREEMENT AND EMAIL TO dan.mullenix@coyote.com Coyote Logistics, LLC is an Equal Opportunity Employer [Load Number - 26843519] [Carrier Legal Name - JOSE CRUZ CAMPOS CRISPIN] [Carrier USDOT - 3514818] Page 3 of 4COYOTE Rate Confirmation Terms and Conditions Load 26843519 The Broker-Carrier Agreement or Carrier Agreement (in each case, the "Agreement") between Coyote Logistics, LLC, a Licensed Property Broker - USDOT # 2236410, and J&A TRANSPORT is amended by the verbal agreement between Dan Mullenix of Coyote Logistics, LLC hereafter referred to as BROKER, and Jose Cruz Campos Crispin of J&A TRANSPORT hereafter referred to as CARRIER, dated 05/27/2022. This confirmation is subject to the terms of the Agreement and this document constitutes an amendment thereto. If the CARRIER has not signed the Agreement, then the rate shown above is the agreed individually negotiated rate and no other rate shall apply including any carrier tariff rate or terms. THIS LOAD SHALL NOT BE DOUBLE BROKERED. No additional charges not listed above may be added by the CARRIER. Any additional charges must appear on a revised confirmation sheet signed by the BROKER. CARRIER must include signed copy of the shipper's bill of lading and any other proof of delivery with invoice to BROKER. Rates, except as specifically designated above, are inclusive of any fuel surcharge. CARRIER certifies that it is in compliance with all requirements of the California Air Resources Board (CARB) that are applicable to the scope of CARRIER's operations, including, but not limited to: Statewide Truck and Bus Regulations, Transport Refrigeration Unit (TRU) Regulations, Tractor-Trailer Greenhouse (GHG) Gas Regulations, and Drayage Truck Regulations. CARRIER also warrants that it is in compliance with any comparable requirements of the Environmental Protection Agency (EPA) and other states, where applicable. CARRIER shall be responsible for any fines imposed on BROKER and/or shipper resulting from noncompliance. CARRIER hereby confirms that it maintains applicable and valid insurance without exclusions that would prevent coverage for the items listed above. CARRIER has at least $100,000.00 in cargo insurance and $1,000,000.00 in automobile liability coverage. CARRIER further confirms that in transporting the shipment described hereinabove, it will comply with all U.S. DOT and FDA regulations applicable to its operations while transporting said shipment, including, but not limited to drivers' hours of service, and the Food Safety Modernization Act (FSMA), if applicable. CARRIER agrees to the attached requirements from the shipper, if any. ALL LOADS ARE SUBJECT TO ELECTRONIC TRACKING By accepting this shipment, CARRIER agrees that it has obtained a written agreement from each driver transporting a shipment tendered by BROKER to CARRIER pursuant to the Agreement in which each driver provides all necessary consents to (i) receiving text messages and/or phone calls from or on behalf of BROKER and (ii) allowing BROKER or its vendor to track such driver's location while transporting such shipment. CARRIER shall comply with all applicable laws relating to the collection, use, storage, retention, disclosure, and disposal of any information CARRIER provides to BROKER, including information regarding the drivers transporting shipments. CARRIER shall indemnify, defend, and hold BROKER and its affiliates harmless from and against any and all claims, damages, liabilities, losses, actions and expenses (including attorneys' fees) arising out of or in connection with CARRIER's breach of this Section. This Section shall survive the expiration or termination of the Agreement between BROKER and CARRIER. PROCESSING OF PERSONAL INFORMATION With regard to personal information (information that describes, is capable of being associated with, or could reasonably be linked, directly or indirectly, with a particular consumer, household, or device) and data and/or information submitted by or on behalf of BROKER in connection with the shipment, CARRIER will only use and process such data and/or information for the purpose of performing the services hereunder and in compliance with applicable law. With regard to personal information collected, received, or otherwise used or processed by CARRIER hereunder, CARRIER shall not: (i) (ii) Sell, rent, release, disclose, disseminate, make available, transfer, or otherwise communicate orally, in writing, or by electronic or other means, personal information to another business or a third party for monetary or other valuable consideration; or Retain, disclose, collect, sell, use, or otherwise process personal information for any purpose other than for the specific purpose of, and as necessary for, performing the services hereunder. For clarity, CARRIER may not retain, use, or disclose the personal information for any other commercial purposes or outside of the direct business relationship between CARRIER and BROKER. CARRIER will notify BROKER promptly via email at privacy@coyote.com within 2 business days of any breach of the requirements under this heading (PROCESSING OF PERSONAL INFORMATION) of if it receives any inquiry, complaint, request or claim from an individual relating to personal information. CARRIER will notify BROKER by emailing privacy@coyote.com within 24 hours of any security incident of which CARRIER becomes aware which affects, or could reasonably be expected to affect, the confidentiality, integrity, or availability of BROKER's information systems or any personal information, data, and/or information submitted by or on behalf of Broker in connection with the shipment. [Load Number - 26843519] [Carrier Legal Name - JOSE CRUZ CAMPOS CRISPIN] [Carrier USDOT - 3514818] Page 4 of 4

With a shift in focus from genes to cells, systems approach is not only revolutionizing cell biology, but is also providing impetus for clinical medicine to shift from a reductionistic to a holistic approach for efficient disease management. This inevitably brings into focus one of the longest unbroken healthcare systems in the world, namely ayurveda, the medical system indigenous to Indian subcontinent. A distinctive feature of ayurveda is its systems approach to health and disease. Through the theoretical framework of vata, pitta and kapha, ayurveda offers a new paradigm for understanding the human system as a networked functional entity wherein system properties are integral components. An open-minded dialogue between the cell-centric systems biology and organism-centric ayurveda can open new exciting vistas for research beneficial to both sciences, which could leave a major imprint on clinical practice.

Page 1 of 3 C.H. Robinson Contract Addendum and Carrier Load Confirmation - #395621605 This load confirmation is confidential information of CH Robinson and may not be disclosed to third parties without CH Robinson's prior written approval. Javier at S&S PRIDE TRUCKING, INC. - T6063286 C.H. Robinson requires automated shipment check-in and in-transit updates from one of the approved shipment status technologies. Additional information about these technologies can be found at www.chrobinson.com. If you require assistance during your check-in process, please use one of our mobile apps, or call (866) 581-0813. C.H. Robinson Communication This load was booked with Austin Patella, (866) 281-6676 x5115, PATEAUS@chrobinson.com. Driver Name: Equipment: linden Van Min L=53 Customer-Specified Equipment Requirements CARRIER DRIVER Download on the GET IT ON App Store Google Play C.H. Robinson's Customer requires that the Carrier arrives at Shipper with the following specific equipment to properly transport this shipment: Pursuant to C.H. Robinson carrier contract, any seals applied to trailer are not to be broken or removed prior to delivery at destination without prior written consent from C.H. Robinson. Carrier shall notate the condition of the seal on the bill of lading upon delivery. Customer Requirements C.H. Robinson's Customer requires that Carrier provide daily in-transit tracking updates, through C.H. Robinson, by 10 a.m. and 3 p.m. Central Time until this shipment is delivered. Safety vests are required when on VEKA property Driver's must have pick up # or CHR Load # FOMBELL, PA DRY VAN LOADS: Shipping is dock 22-28 Compound is dock 35 Receiving is dock 18-22 FOMBELL, PA FLATBED LOADS Smoke Tarps & Edge Protectors Required Trailer must be completely empty, no bulkhead Loading/Unloading during daylight hours only RENO, NV FLATBED LOADS Full tarp required SHIPPER#1: Address: Phone: JPI West 495 East Parr Blvd Reno, NV 89512 Pick Up Date: *Open Pick Up✶ Pick Up Time: Pickup #: Appointment #: 04/19/22 08:00-17:00 (330) 853-4350 Est Wgt 40,000 Units Count Eaches(s) 60 Please ask for and confirm receipt of: Commodity EMPTY RACKS Shipper Instructions Pallets Temp 60 Ref # RECEIVER #1: Address: Veka Delivery Date: 04/21/22-04/22/22 100 Veka Drive *Scheduled Delivery* Fombell, PA 16123 Delivery Time: 00:00-23:59 Phone: (724) 452-1000 Delivery #: Appointment #: Please confirm delivery of: Commodity Est Wgt Units Count Pallets Temp Ref #Page 2 of 3 C.H. Robinson Contract Addendum and Carrier Load Confirmation - · #395621605 EMPTY RACKS Receiver Instructions 40,000 Eaches(s) 60 60 All drivers that need to enter the warehouse must have a mask or other facial covering Warehouse Notes: This facility has check-in restrictions; please contact C.H. Robinson for Customer's detailed requirements. This facility requires trailers to be completely empty before arriving to be loaded; trailers may not contain any personal or commercial items including, but not limited to pallets, load bars, load straps, blankets, dunnage or freight. Service for Load #395621605 Line Haul - FLAT RATE Total: Rate Details Amount Rate 1 $6,364.00 Extended $6,364.00 $6,364.00 SUBMIT FREIGHT BILL TO: CHRW Billing P.O. Box 3470 Chicago, IL 60654 LoadDocs@CHRobinson.com To insure prompt payment, all billing must be accompanied by an invoice with the Carrier Name and C.H. Robinson Load Number Fuel Surcharge Information Please note that C.H. Robinson has included a $1,493.12 fuel surcharge within the listed transportation rate on this confirmation. The fuel surcharge is an estimate based off of a weekly national average fuel price from the U.S. Department of Energy. QUICK PAY and CASH ADVANCE QUICK PAY - If you are a Carrier who utilizes C.H. Robinson's Quick Pay Program, you may email your invoice and required paperwork to LoadDocs@chrobinson.com or visit NavisphereCarrier.com for other scanning options. Funds will be released from C.H. Robinson, minus the fixed discount, within two business days from receipt of complete and legible paperwork. Paperwork received by 12:00 noon (CST) will be counted as same day; paperwork received after 12:00 noon (CST) will count as the next business day. Carriers enrolled in Quick Pay are no longer required to submit original paperwork for payment in addition to using one of our billing methods unless otherwise instructed by C.H. Robinson. Carrier shall retain custody of the original paperwork and provide it to C.H. Robinson upon Request. C.H. Robinson also recommends that Carrier only submit "receipt" for payment once, regardless of billing method to avoid additional fees. If you would like more information about becoming enrolled in Quick Pay, please contact the Quick Pay Department at (800) 326-9977. For a list of our billing options, please visit NavisphereCarrier.com. CASH ADVANCE - Carriers may request a cash advance from C.H. Robinson to be issued at C.H. Robinson's sole discretion as a partial settlement to the agreed upon rate. All cash advances will be deducted from final settlement; including a transaction fee of the greater of 3% of the advance issued or $15 for each individual advance. Directions Any directions given by C.H. Robinson or its Customers, whether orally and/or electronically, are for informational purposes only. It is the Carrier's sole responsibility to confirm that it may lawfully and safely operate its vehicle and its contents over any road, highway, bridge and/or route. Carrier shall be solely responsible for any fines, penalties, or citations that may be levied as a result of operating its vehicle equipment and its contents in any way that may be found to be in violation of any regulation, law or ordinance. Receiver's Driving Directions RECEIVER 1 - Veka: Do NOT arrive more than 15 mins prior to load time, limited parking!! UsePilot in Portersville, PA. I-79 N to exit 87 (Zelienople). At end of ramp L on 68. 1st light take L on rte 19, at 2nd light make R on 288. Cross RR Trx, follow to Y & bear L on 588. Veka is 1.5 miles on R I-79 S to exit 88. L on Rte 19, Right at 2nd light Cross RRTrx, follow to Y & bear L on 588. Veka is 1.5 miles on R.C.H. Robinson Contract Addendum and Carrier Load Confirmation - Page 3 of 3 #395621605 C.H. Robinson Contract Addendum and Carrier Load Confirmation Conditions THIS LOAD CONFIRMATION IS SUBJECT TO THE TERMS OF THE AGREEMENT FOR MOTOR CONTRACT CARRIER SERVICES ("AGREEMENT") PREVIOUSLY EXECUTED BETWEEN OUR COMPANIES AND THIS CONSTITUTES AN ADDENDUM TO THE TERMS OF THAT AGREEMENT. WE AGREE TO PAY THE RATES AND CHARGES SHOWN ABOVE AND NO DIFFERENT TARIFF RATE OR SCHEDULE OF RATES APPLY. THIS LOAD CONFIRMATION IS INCLUSIVE OF ALL CHARGES. UNLESS ORAL AND WRITTEN FAX OBJECTIONS ARE MADE TO ITS TERMS, AT THE EARLIER OF WITHIN TWENTY-FOURS (24) HOURS OF RECEIPT OR PRIOR TO WORK BEING INITIATED, YOU HAVE AGREED TO THESE TERMS. Additional Terms 1. Unless C.H. Robinson provides written notice herein that this term does not apply to this shipment, Carrier's motor vehicle equipment shall be dedicated to C.H. Robinson's exclusive use while transporting the cargo subject to this booking. Carrier's violation of this exclusive use requirement shall result in Carrier's forfeiting its right to be paid for the transportation services contemplated by this Load Confirmation, not as penalty, but as liquidated damages. 2. Cash advance requests made after regular business hours will not be authorized. If Carrier requires a cash advance, Carrier must make arrangements with the C.H. Robinson booking representative during normal business hours and/or upon booking this shipment. Cash advance requests made outside of the C.H. Robinson booking branch's regular business hours may not be authorized. If Carrier requires a cash advance, Carrier must make arrangements with the C.H. Robinson booking branch during its normal business hours and/or upon booking this shipment. 3. This rate is contingent upon successful and on-time completion of all load requirements as orally stipulated or written on this Addendum and rate may be subject to reduction if Carrier fails to complete any applicable terms and conditions. Rate may be reduced if load picks up or delivers after originally scheduled time and date. Carrier acknowledges that failure to complete any terms and conditions on this shipment may jeopardize or result in loss of future business opportunities with C.H. Robinson and/or cancelation of the Agreement. 4. Accessorial charges (including but not limited to labor, detention, and/or layover charges) must be authorized and approved prior to or at time of occurrence. C.H. Robinson will not provide any reimbursement of any non, prior-approved accessorial charges. Carrier shall ensure the bill of lading is notated either when handling is required or when detention occurs, that a lumper receipt is provided when a lumper is hired, and/or that both are included as supporting documents with the Carrier's invoice. All overage, shortage, and damage must be reported to C.H. Robinson immediately, at time of occurrence, and noted on the bill of lading. 5. C.H. Robinson's Customer requires that Carrier provide, through C.H. Robinson, the following electronic shipment status updates via EDI, NavisphereCarrier, the Navisphere driver app, or some other electronic method of providing shipment status updates (unless otherwise specified on this confirmation): - Arrival at and departure from Shipper(s) within thirty (30) minutes of occurrence; - A minimum of one check call per day, prior to 10:00am, each day that Carrier is in possession of this shipment; and - Arrival at and departure from Receiver(s) within thirty (30) minutes of occurrence. 6. For any problems or issues after regular business hours or over the weekends, please contact C.H. Robinson at (800) 233- 5623. 7. For this shipment, Carrier agrees it shall be in possession of relevant and applicable cargo insurance coverage in an amount sufficient to cover the loss or damage of the cargo being transported. Carrier's cargo insurance policy must not exclude from coverage any commodities or cargo carried on this booking. If Carrier's cargo insurance policy contains a schedule of covered vehicles or equipment, Carrier will not transport any cargo on this booking using a vehicle and/or equipment that is not listed as scheduled on Carrier's cargo insurance policy.

Due to the appearance of some new characteristics of the electric power industry such as widely interconnection, high intelligent, the open and interactive, energy internet architecture put forward more new requirements of the electric information network security prevention and the information security faced a severe challenge. At present, the method of information security is extensive, management model and prevention system exist some weak links. This paper put forward a new model to guide the overall development of information security work through the quantization of risk indicator and fuzzy intelligent analysis.

*** Load Confirmation *** CHOPTANK DELIVERING RESULTS. DAILY. Load # 1950534 Choptank Contact Katelyn Compton Page 1 Katelyn.Compton@choptanktransport.com Phone: Fax: (410) 673-1240 (410) 630-1493 Carrier: ISHIP WORLDWIDE INC CUTLER BAY FL 33157 Date: 04/14/2022 Contact: Phone: Fax: Donald Driver: Ext 1432 Order Commodity: easter chocolate Miles: 787.0 Temp: 55.0 CONTINUOUS Pallets: 3 Weight: Trailer: Reference: Cases/Pieces: 43000.0 53 reefer Ricardo Mendoza Cell: (305) 803-2441 Tractor: 23 Trailer: 234 BOLND33522233 405 PU 1 Name: AMERICOLD Date: 04/11/2022 1300 Pallets in: Address: 5 Access Rd PISCATAWAY NJ 08854 Phone: (848) 209-0680 Reference number: PO SPR-157972 Reference number: PO WEB-165125 Contact: Driver Load: N Pieces: 270 Pieces: 135 Warehouse Pallets out: Reference number: PU 551721 Pieces: Weight: 3936.0 Weight: 1968.0 Weight: DEL 2 Name: Address: ALDI Date: 04/12/2022 0200 Pallets in: 4400 S CHARLESTON PIKE SPRINGFIELD OH 45502 Contact: shipping Pallets out: Phone: (937) 323-5500 Driver Load: N Reference number: PO SPR-157972 Reference number: CG APP4545187 Pieces: 270 Pieces: Weight: 3936.0 Weight: DEL 3 Name: ALDI Date: 04/13/2022 0100 Pallets in: Address: 2625 NORTH STOCKBRIDGE ROAD WEBBERVILLE MI 48892 Pallets out: Contact: RECEIVER Phone: (517) 521-3907 Driver Load: N Reference number: PO WEB-165125 Reference number: CG 4545233 Pieces: 135 Pieces: Weight: 1968.0 Weight: Payment Carrier Freight Pay: $2,800.00 Labor/Lumper 40.00 Labor/Lumper 35.00 Total Carrier Pay: $2,875.00Instructions AMERICOLD - ALDIBAIL: LUMPER FEES: FOR ANY PAYMENTS OTHER THAN CASH THE CONVENIENCE FEE FOR PROCESSING A COMCHECK OR CREDIT CARD WILL NOT BE REIMBURSED. AMERICOLD - ALDIBAIL: *ALL RECEIVING LOCATIONS ARE DRIVER UNLOAD FACILITIES. IF YOU CHOOSE TO HIRE THE LUMPER SERVICE, DETENTION WILL NOT BE PAID UNLESS OTHERWISE APPROVED. FLOOR LOADS & SLIPS SHEET LOADS PAY DETENTION AFTER 4 HOURS OF BEING DETAINED. *DETENTION STARTS 3 HOURS AFTER SCHEDULED APPT TIME AT SHIPPING LOCATIONS. IF FCFS, DETENTION WILL NOT BE PAID. DRIVER MUST CALL INTO CHOPTANK AFTER 1.5 HOURS OF SCHEDULED APPOINTMENT IN ORDER TO GIVE THE CUSTOMER A CHANCE TO GET YOU LOADED/UNLOADED BEFORE DETENTION TIME BEGINS. NO CALL, NO DETENTION APPROVED. NO EXCEPTIONS. *ANY DETENTION REQUESTS MUST BE SUBMITTED WITHIN 24 HOURS OF DELIVERY APPOINTMENT FROM EACH STOP. A COPY OF THE BOL WITH THE IN AND OUT TIMES ALONG WITH ANY OTHER INFORMATION PERTAINING TO THE DETENTION MUST BE PROVIDED AT THIS TIME. ANY REQUESTS MADE AFTER THAT TIME WINDOW WILL NOT BE SUBMITTED OR APPROVED. **ALL TRUCKS MUST BE ABLE TO SCALE 43,000LBS. FAILURE TO DO SO WITH PRODUCT NEEDING TO BE CUT WITHOUT APPROVAL WILL RESULT IN FINES TO BE ASSESSED BY THE CUSTOMER** *RATE CONFIRMATION WILL BE SIGNED AND RETURNED BEFORE THE DRIVER IS ABLE TO BE DISPATCHED. NO PAYMENT WILL BE ISSUED TO CARRIER WITHOUT THIS DOCUMENT. *CARRIER MUST ARRIVE ON TIME FOR PICK UP, DELIVERY APPOINTMENTS AND/OR FCFS WINDOWS. LATE AND/OR MISSED APPOINTMENTS MAY BE SUBJECT TO PENALTY FEES. * TRAILER MUST ARRIVE CLEAN, DRY AND ODOR FREE. IF REEFER LOAD, TRAILER MUST ARRIVE PRECOOLED TO TEMPARATURE GIVEN TO DRIVER UPON DISPATCH. *DRIVER MUST CALL IN TO VERIFY PIECE COUNT, PALLETS, TEMPERATURE (IF APPLICABLE), AND DELIVERY LOCATION WHILE STILL AT SHIPPING LOCATION. THIS INCLUDES WATCHING AND COUNTING THE PRODUCT AS IT IS BEING LOADED TO CHECK FOR ACCURATE COUNT AND DAMAGES. IF NOT ALLOWED ON THE DOCK, CONTACT CHOPTANK DISPATCH IMMEDIATELY. *TRAILER MUST BE SEALED BEFORE THE DRIVER LEAVES THE SHIPPING FACILITY AND SEAL NUMBER MUST BE RECORDED ON BILL OF LADING. *DRIVERS ARE RESPONSBILE FOR SECURING CARGO AND DELIVERING AS IT WAS LOADED. *CHOPTANK IS NOT RESPONSIBLE FOR ANY RESTACK, LEANING, REPACKS, SPILLAGE FEES ASSESED BY THE LUMPER SERVICE WITHOUT PROPER DOCUMENTATION ACQUIRED BY THE SHIPPER. *LUMPER FEES MUST BE REPORTED AT TIME OF DELIVERY. THEY ALSO REQUIRE A VALID RECEIPT FOR REIMBURSEMENT. UNAPPROVED, INELIDGIBLE, HANDWRITTEN RECEIPTS, OR DRIVER UNLOADS MAY NOT BE REIMBURSED, UNLESS OTHERWISE DIRECTED. *DRIVER MUST ACCEPT TRUCKER TOOL THROUGH THE PHONE TEXT MESSAGE AND PROPER PROCEDURES UPON DISPATCH OF THE LOAD. FAILURE TO DOWNLOAD AND ACCEPT TRUCKER TOOL WILL RESULT IN CARRIER REMOVAL FROM THE LOAD AND A "NO LOAD ORDER" BEING ISSUED AT THE SHIPPER. NO FUEL ADVANCES WILL BE GIVEN WITHOUT TRACKING ACCEPTED BY THE DRIVER PRIOR TO PICK UP. CANCELLING TRUCKER TOOLS DURING ANY PART OF TRANSIT IS NOT PERMITTED AND WILL RESULT IN A FINE NOT TO EXCEED $100 PER DAY. IF TRACKING VIA TRUCKER TOOLS IS NOT STARTED, DETENTION AND LAYOVER CANNOT BE PAID **DRIVER MUST PULP PRODUCT UPON ENTERING THE TRAILER. FAILURE TO DO SO AND HAVE PHOTO PROOF WILL RESULT IN CLAIMS IF PRODUCT IS REJECTED AT RECEIVER! *DRIVER IS REQUIRED TO CALL IN AT LEAST TWICE A DAY, MORNING AND EVENING TO CONFIRM LOCATION. ALL REFRIGERATED LOADS MUST REPORT TEMPERATURE OF TRAILER AS WELL. *FAILURE TO FOLLOW ANY PROCEDURES MENTIONED ABOVE MAY RESULT IN FINES AND/OR FEES.Agreement Please sign and fax back to Katelyn Compton CARRIER REP SIGNATURE: •THIS RATE CONFIRMATION WILL CONFIRM THE RATE & CONTRACT TERMS AGREED TO IN THE MASTER CARRIER CONTRACT BY CARRIER AND CHOPTANK. •DRIVER MUST CALL CHOPTANK UPON ARRIVAL AND DEPARTURE @ EACH STOP AS WELL AS DAILY TRANSIT CHECK CALLS. FAILURE TO DO SO WILL RESULT IN A $25 FINE FOR EACH OCCURENCE. •TRACKING IS REQUIRED FOR ALL LOADS - FAILURE TO ACTIVATE TRACKING WHEN REQUESTED OR THE DEACTIVATION OF THE TRACKING PRIOR TO DELIVERY OF THE CARGO TO THE FINAL DESTINATION WILL RESULT IN A $100 FINE, AND WILL DIMINISH THE DEFENSE OF ANY CARGO CLAIM. ⚫DRIVERS ARE RESPONSIBLE FOR CASE COUNT AND CONDITION OF THE FREIGHT. ⚫DRIVERS ARE RESPONSIBLE TO MAKE SURE SEALS ARE SECURE AND INTACT BEFORE LEAVING SHIPPER. SEAL INTEGRITY MUST BE MAINTAINED THORUGH DELIVERY. ONLY RECEIVER MAY BREAK SEAL. FAILURE TO ADHERE TO SEAL POLICY MAY RESULT IN REJECTION OF PRODUCT AND FULL CLAIM. •IF SHORTAGE, DAMAGE, DELAY OR ACCIDENT, CONTACT THE REP RESPONSIBLE FOR IMMEDIATE INSTRUCTION. ⚫IF DRIVER IS NOT LOADED/UNLOADED WITHIN A HOUR OF BEING ON-TIME, CONTACT THE CHOPTANK REP. ⚫LOADING/UNLOADING CHARGES AND PALLET FEES MUST BE AUTHORIZED DAY OF AND ORIGINAL RECEIPT MUST BE PRESENTED TO BE PAID. •ALL EQUIPMENT MUST BE 102" WIDE UNLESS OTHERWISE NOTED AND FOR EXCLUSIVE USE ONLY. ALSO MUST BE CLEAN, DRY, ODOR FREE AND DAMAGE FREE SHIPMENTS TRANSITING CALIFORNIA ⚫CARRIER (AND ITS AGENT) CERTIFIES THAT ANY TRU (REFRIGERATED UNIT) EQUIPMENT FURNISHED WILL BE IN COMPLIANCE WITH THE "IN-USE" REQUIREMENTS OF CALIFORNIA'S TRU REGULATIONS. REFRIGERATED FREIGHT ⚫ALL SHIPMENTS REQUIRING REFRIGERATION MUST HAVE THE CAPABILITY TO DOWNLOAD TEMPERATURE HISTORY OR HAVE A TEMPERATURE TRACKING DEVICE PLACED ON THE ORDER. ⚫ALL DRIVERS WILL ENSURE THAT THE PRODUCT WILL BE LOADED AT THE TEMPERATURE THAT IS REQUIRED FOR THE PRODUCT TO BE HAULED. •REEFER UNIT MUST BE SET ON CONTINUOUS •MUST BE CERTIFIED IN THE FOOD SAFETY MODERNIZATION ACT (FSMA) SEND FREIGHT BILLS TO: MAIL OR OVERNIGHT MAIL: CHOPTANK TRANSPORT P.O. BOX 99 3601 CHOPTANK RD EMAIL/FAX: ebilling@choptanktransport.com (410) 305-7210 **** PLEASE REFERENCE LOAD NUMBER ON BILLING INVOICE**** Load # 1950534 PRESTON, MD 21655 FACTORING COMPANIES DIRECT ALL INQUIRIES TO FACTOR@CHOPTANKTRANSPORT.COM CHECK OUT OUR WEBSITE AT WWW.CHOPTANKTRANSPORT.COMChoptank Transport Choptank Transport has contracted with Pegasus/TRANSFLO Express to get all of your documents in easier, faster and with more certainty than in the past. You will be able to get your trip information to us in a matter of minutes instead of days. TRANSFLO Express allows you to have your documents scanned at 500 truck stop locations throughout the country and get immediate confirmation that the documents have been sent. In addition, you will be able to log onto the Internet and not only view your documents, but also see exactly when they were delivered to Choptank Transport. This process is integrated with our billing and payroll systems, helping to ensure accurate, on-time settlement of your trips. How does it work Fax to 410-673-2724 (no fee charged) E-mail to "ebilling@choptanktransport.com" (no fee charged) or via TRANSFLO (instructions below) • Fill out your trip sheet • Remove all staples & paper clips • Place the documents you normally mail in a neat stack behind the trip sheet • Hand the documents to the cashier at the fuel desk at any of 500 scan stations nationwide • The cashier scans your documents, prints a receipt and hands back to you immediately after scanning You pay nothing at the truck stop for the service • • It is billed to Choptank Transport and will be deducted from your settlement just like TripPak is today. CARRIER NAME: ORDER NUMBER: ISHIP WORLDWIDE INC 1950534 NUMBER OF PAGES (Include this page in your count):_ CKTH CKTH

Tennessee Steel Haulers, LLC. P.O. Box 78189 Nashville, TN 37207-8189 TSH TENNESSEE STEEL HAULERS, LLC Dispatcher: Melisa Parker Phone: 931-308-1785 E-mail: melisa.parker@tenhagent.com Fax: 931-563-7905 Emergency Phone: 931-563-7909 Load and Rate Confirmation Agreement Load #1925348 To accept load please sign and fax this sheet back to: 931-563-7905 Load Number: 1925348 TSH Carrier Number: 13057 MC Number: 510109 Carrier Name: BG Xpress LLC Attention: BG Confirmation Sent To: BGXLLC@YAHOO.COM Load Information Miles: 185.00 Commodity: Other Commodity Desc: AUTOMOTIVE MATERIALS Ref Number: 107597 Driver Name: XX Truck Number: X Trailer Number: X Carrier Phone: 903-537-7030 Carrier Fax: 270-721-1074 Weight: 0 Trailer Req: Van Load Size: Full Pickup Number: AETC107597 #1 Shipper Company: AMERICAN HOWA Address: 2700 25th Ave SE City/St/Zip: Jasper, AL 35501 Thursday, 11/09/2023 from 08:00 - 16:00 TIME SENSITIVE-AUTOMOTIVE MATERIALS-TRACKING REQUIRED. MUST SEND IN BOL WHEN LOADED TO EMAIL: MELISA.PARKER@TENHAGENT.COM ***FAILURE TO UPDATE WHEN LOADED WITH ETA AND BOL WILL RESULT IN A 15% REDUCTION OF RATE. BACK SOLICITATION IS STRICTLY PROHIBITED. INFORMATION IS CONFIDENTIAL AND FOR DRIVER USE OF PICK.DELIVERY ONLY. SOLICITING TO SHIPPER/RECEIVER/ETC WILL RESULT IN LEGAL ACTION. ACCEPTANCE OF THIS TENDER IS ACCEPTANCE OF ALL LISTED TERMS. #2 Consignee/Final Destination Company: NISSAN MFG PLANT- SMYRNA, TN Address: 983 NISSAN DR Address 2: DOCK 30 City/St/Zip: Smyrna, TN 37167 Thursday, 11/09/2023 at 21:00Tennessee Steel Haulers, LLC. P.O. Box 78189 Nashville, TN 37207-8189 TSH TENNESSEE STEEL HAULERS, LLC Dispatcher: Melisa Parker Phone: 931-308-1785 Fax: 931-563-7905 Emergency Phone: 931-563-7909 Load and Rate Confirmation Agreement Load #1925348 To accept load please sign and fax this sheet back to: 931-563-7905 Agreement: This contract rate addendum is entered into on this date, 11/09/2023, by and between Tennessee Steel Haulers, LLC. (hereinafter referred to as "Broker") and BG Xpress LLC (hereinafter referred to as "Carrier"). Carrier assumes all liability for all delays, loss and/or damage to the shipment(s) transported pursuant to this Load and Rate Confirmation Agreement for the full value of the freight transported. Carrier shall be responsible for any loss or damage which Broker may incur or pay to its customers on account of any transportation services performed by Carrier for Broker. Carrier Pay: Broker hereby agrees to pay Carrier 30 days after receipt by Broker of Carrier's invoice, signed bill of lading (including proof of pick-up and delivery) and Broker's completed copy of this contract rate addendum. All of these items must be sent via the invoicing methods below. Carrier shall always invoice Broker directly for its freight charges and not Broker's customer. This rate is all inclusive: Fuel Surcharges, Accessorial Charges, Driver Assist Charges, Notification Charges, etc. Carrier agrees to ensure the Broker will receive proof of delivery within 48 hours of delivery. Operations/Check Calls 1. Carrier (Dispatcher/Driver) must call immediately if there are any deviations from the Pick Up or Delivery dates and/or times stated here within. Signature of this load and rate confirmation agreement form is confirmation to provide the service requested. 2. Carrier must call with an estimated time of arrival for the Pick Up. 3. Driver/Dispatcher must call at the time of Pick Up with Load Time, Pieces and Weight, and Pick-Up Number. 4. Driver/Dispatcher must call at the time of Delivery at each Stop-off and at the Final Destination with Unload Time and a legible receipt signature on the proof of delivery. 5. Carrier agrees to maintain current insurance in accordance with signed broker carrier agreement. Amount to invoice TSH: $600.00 Carrier: BG Xpress LLC MC #: 510109 By: Title: Fax confirmation to: 931-563-7905 Invoicing Methods 1. Email .pdf or .tiff files to: tshcarrier@tenh.com (Preferred Method) Please note any file type other than a .pdf or .tiff could delay the processing and payment of your invoices and proof of deliveries. 2. Fax to: (615) 290-5353 3. US Mail: TSH Attn: Billing Dept. P. O. Box 78189 Nashville, TN 37207

Individual cells in multicellular organisms constantly explore their microenvironment, or niche, to obtain spatial information that is used to regulate cell behavior to maintain tissue integrity. The extracellular matrix (ECM) is an important source of such spatial information. Binding of the integrin family receptors to the ECM triggers formation of integrin adhesion complexes (IACs) that link the ECM network to cellular cytoskeleton via remarkably large multiprotein complexes collectively referred to as the integrin adhesome. Recent advances in proteomics have enabled researchers to study the IAC composition in detail. Various biochemical IAC isolation methods and culture conditions have been employed to study the composition and dynamics of integrin-mediated adhesions mainly in fibroblasts and lymphoblasts. These studies have led to identification of daunting lists of potential IAC components. This review focuses on the current status of proteomics-driven research seeking to understand integrin functions by comprehensive analysis of IAC components. These systems level approaches have revealed the complexity of biochemical and biomechanical signals that are processed at IACs and provide a novel insight into how these signals are conveyed to regulate cellular behavior.

We investigated whether Black-White biracial individuals are perceived as Black in the domain of evaluation. Previous research has documented that White perceivers' negative evaluation of one Black person leads to a negative implicit evaluation of another Black person belonging to the same minimal group. We built upon this out-group transfer effect by investigating whether perceivers also transferred negative implicit attitudes from one Black person to a novel Black-White biracial person. In three experiments, participants learned about a Black individual who performed undesirable behaviors and were then introduced to a new group member. White perceivers formed negative attitudes toward the original individual and transferred these attitudes to the new group member if she was Black or Biracial, but not if she was White (Experiment 1) or Asian (Experiment 2). Experiment 3 demonstrated that only White participants exhibited transfer to the new Black and Biracial group members; Black participants did not.

As healthcare reimbursement is increasingly tied to value-of-service, it is critical for the genetic counselor (GC) profession to demonstrate the value added by GCs through outcomes research. We conducted a rapid systematic literature review to identify outcomes of genetic counseling. Web of Science (including PubMed) and CINAHL databases were systematically searched to identify articles meeting the following criteria: 1) measures were assessed before and after genetic counseling (pre-post design) or comparisons were made between a GC group vs. a non-GC group (comparative cohort design); 2) genetic counseling outcomes could be assessed independently of genetic testing outcomes, and 3) genetic counseling was conducted by masters-level genetic counselors, or non-physician providers. Twenty-three papers met the inclusion criteria. The majority of studies were in the cancer genetic setting and the most commonly measured outcomes included knowledge, anxiety or distress, satisfaction, perceived risk, genetic testing (intentions or receipt), health behaviors, and decisional conflict. Results suggest that genetic counseling can lead to increased knowledge, perceived personal control, positive health behaviors, and improved risk perception accuracy as well as decreases in anxiety, cancer-related worry, and decisional conflict. However, further studies are needed to evaluate a wider array of outcomes in more diverse genetic counseling settings.

Page 1 of 3 C.H. Robinson Contract Addendum and Carrier Load Confirmation - #397952023 This load confirmation is confidential information of CH Robinson and may not be disclosed to third parties without CH Robinson's prior written approval. Javier at S&S PRIDE TRUCKING, INC. - T6063286 C.H. Robinson requires automated shipment check-in and in-transit updates from one of the approved shipment status technologies. Additional information about these technologies can be found at www.chrobinson.com. If you require assistance during your check-in process, please use one of our mobile apps, or call (866) 581-0813. CARRIER DRIVER Download on the GET IT ON Google Play App Store C.H. Robinson Communication This load was booked with Austin Patella, (866) 281-6676 x5115, PATEAUS@chrobinson.com. Customer-Specified Equipment Requirements Equipment: Van - Min L=53 Customer Requirements **All after hours issues and accessorials must be reported to CHR-MST Division 24/7 at 866-360-5230. Late deliveries without notice are subject to fine. In order to be compensated for detention, driver must get in and out times signed by the warehouse supervisor. SHIPPER#1: Address: Phone: JOHNSON CONTROLS INC 100 JCI way YORK, PA 17406 Pick Up Date: *Open Pick Up* Pick Up Time: Pickup #: Appointment #: 05/17/22 13:00-15:00 Email 5.12 Please ask for and confirm receipt of: Commodity Water Coils (717) 978-3459 Est Wgt 25,000 Units (s) Count Pallets Temp Ref # Email 4.28 Shipper Instructions Email 5.12 RECEIVER #1: Address: Johnson Controls 2001 Business Loop 136 W Albany, MO 64402 Delivery Date: *Scheduled Delivery* 05/19/22 Delivery Time: 08:00-17:00 Delivery #: Email 5.12 Phone: (660) 726-6107 Appointment #: Please confirm delivery of: Commodity Water Coils Est Wgt 25,000 Units (s) Count Pallets Temp Ref # Email 4.28 Receiver Instructions Email 5.12Page 2 of 3 C.H. Robinson Contract Addendum and Carrier Load Confirmation - #397952023 Service for Load #397952023 Line Haul - FLAT RATE Total: Rate Details Amount 1 Rate $2,400.00 Extended $2,400.00 $2,400.00 SUBMIT FREIGHT BILL TO: CHRW Billing P.O. Box 3470 Chicago, IL 60654 LoadDocs@CHRobinson.com To insure prompt payment, all billing must be accompanied by an invoice with the Carrier Name and C.H. Robinson Load Number Fuel Surcharge Information Please note that C.H. Robinson has included a $791.06 fuel surcharge within the listed transportation rate on this confirmation. The fuel surcharge is an estimate based off of a weekly national average fuel price from the U.S. Department of Energy. QUICK PAY and CASH ADVANCE QUICK PAY - If you are a Carrier who utilizes C.H. Robinson's Quick Pay Program, you may email your invoice and required paperwork to LoadDocs@chrobinson.com or visit NavisphereCarrier.com for other scanning options. Funds will be released from C.H. Robinson, minus the fixed discount, within two business days from receipt of complete and legible paperwork. Paperwork received by 12:00 noon (CST) will be counted as same day; paperwork received after 12:00 noon (CST) will count as the next business day. Carriers enrolled in Quick Pay are no longer required to submit original paperwork for payment in addition to using one of our billing methods unless otherwise instructed by C.H. Robinson. Carrier shall retain custody of the original paperwork and provide it to C.H. Robinson upon Request. C.H. Robinson also recommends that Carrier only submit "receipt" for payment once, regardless of billing method to avoid additional fees. If you would like more information about becoming enrolled in Quick Pay, please contact the Quick Pay Department at (800) 326-9977. For a list of our billing options, please visit NavisphereCarrier.com. CASH ADVANCE - Carriers may request a cash advance from C.H. Robinson to be issued at C.H. Robinson's sole discretion as a partial settlement to the agreed upon rate. All cash advances will be deducted from final settlement; including a transaction fee of the greater of 3% of the advance issued or $15 for each individual advance. Directions Any directions given by C.H. Robinson or its Customers, whether orally and/or electronically, are for informational purposes only. It is the Carrier's sole responsibility to confirm that it may lawfully and safely operate its vehicle and its contents over any road, highway, bridge and/or route. Carrier shall be solely responsible for any fines, penalties, or citations that may be levied as a result of operating its vehicle equipment and its contents in any way that may be found to be in violation of any regulation, law or ordinance. Shipper's Driving Directions SHIPPER 1 - JOHNSON CONTROLS INC: ***STARTING MONDAY 4/20/20, ALL DRIVERS WILL BE REQUIRED TO HAVE A VALID FACE MASK UPON ARRIVAL OR THEY WILL BE REJECTED.***C.H. Robinson Contract Addendum and Carrier Load Confirmation - Page 3 of 3 #397952023 C.H. Robinson Contract Addendum and Carrier Load Confirmation Conditions THIS LOAD CONFIRMATION IS SUBJECT TO THE TERMS OF THE AGREEMENT FOR MOTOR CONTRACT CARRIER SERVICES ("AGREEMENT") PREVIOUSLY EXECUTED BETWEEN OUR COMPANIES AND THIS CONSTITUTES AN ADDENDUM TO THE TERMS OF THAT AGREEMENT. WE AGREE TO PAY THE RATES AND CHARGES SHOWN ABOVE AND NO DIFFERENT TARIFF RATE OR SCHEDULE OF RATES APPLY. THIS LOAD CONFIRMATION IS INCLUSIVE OF ALL CHARGES. UNLESS ORAL AND WRITTEN FAX OBJECTIONS ARE MADE TO ITS TERMS, AT THE EARLIER OF WITHIN TWENTY-FOURS (24) HOURS OF RECEIPT OR PRIOR TO WORK BEING INITIATED, YOU HAVE AGREED TO THESE TERMS. Additional Terms 1. Unless C.H. Robinson provides written notice herein that this term does not apply to this shipment, Carrier's motor vehicle equipment shall be dedicated to C.H. Robinson's exclusive use while transporting the cargo subject to this booking. Carrier's violation of this exclusive use requirement shall result in Carrier's forfeiting its right to be paid for the transportation services contemplated by this Load Confirmation, not as penalty, but as liquidated damages. 2. Cash advance requests made after regular business hours will not be authorized. If Carrier requires a cash advance, Carrier must make arrangements with the C.H. Robinson booking representative during normal business hours and/or upon booking this shipment. Cash advance requests made outside of the C.H. Robinson booking branch's regular business hours may not be authorized. If Carrier requires a cash advance, Carrier must make arrangements with the C.H. Robinson booking branch during its normal business hours and/or upon booking this shipment. 3. This rate is contingent upon successful and on-time completion of all load requirements as orally stipulated or written on this Addendum and rate may be subject to reduction if Carrier fails to complete any applicable terms and conditions. Rate may be reduced if load picks up or delivers after originally scheduled time and date. Carrier acknowledges that failure to complete any terms and conditions on this shipment may jeopardize or result in loss of future business opportunities with C.H. Robinson and/or cancelation of the Agreement. 4. Accessorial charges (including but not limited to labor, detention, and/or layover charges) must be authorized and approved prior to or at time of occurrence. C.H. Robinson will not provide any reimbursement of any non, prior-approved accessorial charges. Carrier shall ensure the bill of lading is notated either when handling is required or when detention occurs, that a lumper receipt is provided when a lumper is hired, and/or that both are included as supporting documents with the Carrier's invoice. All overage, shortage, and damage must be reported to C.H. Robinson immediately, at time of occurrence, and noted on the bill of lading. 5. C.H. Robinson's Customer requires that Carrier provide, through C.H. Robinson, the following electronic shipment status updates via EDI, NavisphereCarrier, the Navisphere driver app, or some other electronic method of providing shipment status updates (unless otherwise specified on this confirmation): - Arrival at and departure from Shipper(s) within thirty (30) minutes of occurrence; - A minimum of one check call per day, prior to 10:00am, each day that Carrier is in possession of this shipment; and - Arrival at and departure from Receiver(s) within thirty (30) minutes of occurrence. 6. For any problems or issues after regular business hours or over the weekends, please contact C.H. Robinson at (800) 233- 5623. 7. For this shipment, Carrier agrees it shall be in possession of relevant and applicable cargo insurance coverage in an amount sufficient to cover the loss or damage of the cargo being transported. Carrier's cargo insurance policy must not exclude from coverage any commodities or cargo carried on this booking. If Carrier's cargo insurance policy contains a schedule of covered vehicles or equipment, Carrier will not transport any cargo on this booking using a vehicle and/or equipment that is not listed as scheduled on Carrier's cargo insurance policy.

Protein-Protein Interactions (PPIs) are essential to most biological processes and play a critical role in most cellular functions. With the development of high-throughput biological techniques and in si/ico methods, a large number of PPI data have been generated for various organisms, but many problems remain unsolved. These factors promoted the development of the in silico methods based on machine learning to predict PPIs. In this study, we propose a novel method by combining ensemble Rotation Forest (RF) classifier and Discrete Cosine Transform (DCT) algorithm to predict the interactions among proteins. Specifically, the protein amino acids sequence is transformed into Position-Specific Scoring Matrix (PSSM) containing biological evolution information, and then the feature vector is extracted to present protein evolutionary information using DCT algorithm; finally, the ensemble rotation forest model is used to predict whether a given protein pair is interacting or not. When performed on Yeast and H. pylori data sets, the proposed method achieved excellent results with an average accuracy of 98.54% and 88.27%. In addition, we achieved good prediction accuracy of 98.08%, 92.75%, 98.87% and 98.72% on independent data sets (C.elegans, E.coli, Hsapiens and M.muscu/us). In order to further evaluate the performance of our method, we compare it with the state-of-the-art Support Vector Machine (SVM) classifier and get good results.

C.H. Robinson Contract Addendum and Carrier Load Confirmation - Page 1 of 3 #448050185 This load confirmation is confidential information of CH Robinson and may not be disclosed to third parties without CH Robinson's prior written approval. General Contact at HCM EXPRESS LLC - T6222752 DBA: HCM EXPRESS LLC C.H. Robinson requires automated shipment check-in and in-transit updates from one of the approved shipment status technologies. Additional information about these technologies can be found at www.chrobinson.com. If you require assistance during your check-in process, please use one of our mobile apps, or call (888) 278-9441. CARRIER DRIVER Download on the GET IT ON App Store Google Play C.H. Robinson Communication Thank you for your business. Taren Barnard, CpcPrtRprs, Dallas Capacity - 8454 Parkwood Blvd, Plano, Texas, (866) 403-8776, BARNTAR@chrobinson.com. Ext 1237 Driver Name: Tractor #: Equipment: Bill Jameson HCM T102 Van Min L=53 Customer-Specified Equipment Requirements Trailer #: T1001 Customer Requirements Carrier shall notify Customer through C.H. Robinson of any real or perceived delays in meeting the scheduled date and times of this shipment. This shipment has equipment restrictions; please contact Customer through C.H. Robinson for details. The Customer/Shipper/Receiver assesses financial penalties for arriving late for or missing pick-up or delivery appointments. SHIPPER#1: Address: KI - High Point 217 Feld Ave High Point, NC 27263 Pick Up Date: *Open Pick Up* Pick Up Time: Pickup #: Appointment #: 9/14/23 06:00-15:00 449541; 413701; 394613 Phone: Please ask for and confirm receipt of: Commodity Chaise Lounges, Couches, Daybeds, Lounges, Lovesea Est Wgt 1,117 Units Count Carton(s) 11 Pallets Temp Ref # Chaise Lounges, Couches, Daybeds, Lounges, Lovesea 194 Carton(s) 6 Chaise Lounges, Couches, Daybeds, Lounges, Lovesea 163 Carton(s) 5 Shipper Instructions RECEIVER #1: Address: CRI 15025 Farm Creek Dr Woodbridge, VA 22191 *Scheduled Delivery* Delivery Date: Delivery Time: Delivery #: 9/15/23 13:00 Appt. KI Order 449541; 1450015200; KI Order 413701; 1450 Phone: Please confirm delivery of: Appointment #: Commodity Chaise Lounges, Couches, Daybeds, Lounges, Lovesea Est Wgt 1,117 Units Carton(s) Count Pallets Temp 11 Ref # Chaise Lounges, Couches, Daybeds, 194 Carton(s) 6C.H. Robinson Contract Addendum and Carrier Load Confirmation Lounges, Lovesea Chaise Lounges, Couches, Daybeds, Lounges, Lovesea 163 Carton(s) 5 Receiver Instructions - Page 2 of 3 #448050185 Call 24 Hrs B4.JEN BROWN 7034938112 KI Order # 449541; Destination requires an appointment or notification.; Call 24 Hrs B4.JEN BROWN 7034938112 KI Order # 394613 Service for Load #448050185 Line Haul - FLAT RATE Total: Rate Details Amount Rate Extended 1 $800.00 $800.00 $800.00 SUBMIT FREIGHT BILL TO: CHRW Quick Pay Billing P.O. Box 3474 Chicago, IL 60654 LoadDocs@CHRobinson.com To insure prompt payment, all billing must be accompanied by an invoice with the Carrier Name and C.H. Robinson Load Number Fuel Surcharge Information Please note that C.H. Robinson has included a $163.08 fuel surcharge within the listed transportation rate on this confirmation. The fuel surcharge is an estimate based off of a weekly national average fuel price from the U.S. Department of Energy. QUICK PAY and CASH ADVANCE QUICK PAY - If you are a Carrier who utilizes C.H. Robinson's Quick Pay Program, you may email your invoice and required paperwork to Load Docs@chrobinson.com or visit NavisphereCarrier.com for other scanning options. Funds will be released from C.H. Robinson, minus the fixed discount, within two business days from receipt of complete and legible paperwork. Paperwork received by 12:00 noon (CST) will be counted as same day; paperwork received after 12:00 noon (CST) will count as the next business day. Carriers enrolled in Quick Pay are no longer required to submit original paperwork for payment in addition to using one of our billing methods unless otherwise instructed by C.H. Robinson. Carrier shall retain custody of the original paperwork and provide it to C.H. Robinson upon Request. C.H. Robinson also recommends that Carrier only submit "receipt" for payment once, regardless of billing method to avoid additional fees. If you would like more information about becoming enrolled in Quick Pay, please contact the Quick Pay Department at (800) 326-9977. For a list of our billing options, please visit NavisphereCarrier.com. CASH ADVANCE - Carriers may request a cash advance from C.H. Robinson to be issued at C.H. Robinson's sole discretion as a partial settlement to the agreed upon rate. All cash advances will be deducted from final settlement; including a transaction fee of the greater of 3% of the advance issued or $15 for each individual advance.C.H. Robinson Contract Addendum and Carrier Load Confirmation - Page 3 of 3 #448050185 C.H. Robinson Contract Addendum and Carrier Load Confirmation Conditions THIS LOAD CONFIRMATION IS SUBJECT TO THE TERMS OF THE AGREEMENT FOR MOTOR CONTRACT CARRIER SERVICES ("AGREEMENT") PREVIOUSLY EXECUTED BETWEEN OUR COMPANIES AND THIS CONSTITUTES AN ADDENDUM TO THE TERMS OF THAT AGREEMENT. WE AGREE TO PAY THE RATES AND CHARGES SHOWN ABOVE AND NO DIFFERENT TARIFF RATE OR SCHEDULE OF RATES APPLY. THIS LOAD CONFIRMATION IS INCLUSIVE OF ALL CHARGES. UNLESS ORAL AND WRITTEN FAX OBJECTIONS ARE MADE TO ITS TERMS, AT THE EARLIER OF WITHIN TWENTY-FOURS (24) HOURS OF RECEIPT OR PRIOR TO WORK BEING INITIATED, YOU HAVE AGREED TO THESE TERMS. Additional Terms 1. Unless C.H. Robinson provides written notice herein that this term does not apply to this shipment, Carrier's motor vehicle equipment shall be dedicated to C.H. Robinson's exclusive use while transporting the cargo subject to this booking. Carrier's violation of this exclusive use requirement shall result in Carrier's forfeiting its right to be paid for the transportation services contemplated by this Load Confirmation, not as penalty, but as liquidated damages. 2. Cash advance requests made after regular business hours will not be authorized. If Carrier requires a cash advance, Carrier must make arrangements with the C.H. Robinson booking representative during normal business hours and/or upon booking this shipment. Cash advance requests made outside of the C.H. Robinson booking branch's regular business hours may not be authorized. If Carrier requires a cash advance, Carrier must make arrangements with the C.H. Robinson booking branch during its normal business hours and/or upon booking this shipment. 3. This rate is contingent upon successful and on-time completion of all load requirements as orally stipulated or written on this Addendum and rate may be subject to reduction if Carrier fails to complete any applicable terms and conditions. Rate may be reduced if load picks up or delivers after originally scheduled time and date. Carrier acknowledges that failure to complete any terms and conditions on this shipment may jeopardize or result in loss of future business opportunities with C.H. Robinson and/or cancelation of the Agreement. 4. Accessorial charges (including but not limited to labor, detention, and/or layover charges) must be authorized and approved prior to or at time of occurrence. C.H. Robinson will not provide any reimbursement of any non, prior-approved accessorial charges. Carrier shall ensure the bill of lading is notated either when handling is required or when detention occurs, that a lumper receipt is provided when a lumper is hired, and/or that both are included as supporting documents with the Carrier's invoice. All overage, shortage, and damage must be reported to C.H. Robinson immediately, at time of occurrence, and noted on the bill of lading. 5. C.H. Robinson's Customer requires that Carrier provide, through C.H. Robinson, the following electronic shipment status updates via EDI, NavisphereCarrier, the Navisphere driver app, or some other electronic method of providing shipment status updates (unless otherwise specified on this confirmation): - Arrival at and departure from Shipper(s) within thirty (30) minutes of occurrence; - A minimum of one check call per day, prior to 10:00am, each day that Carrier is in possession of this shipment; and - Arrival at and departure from Receiver(s) within thirty (30) minutes of occurrence. 6. For any problems or issues after regular business hours or over the weekends, please contact C.H. Robinson at (866) 403- 8771. 7. For this shipment, Carrier agrees it shall be in possession of relevant and applicable cargo insurance coverage in an amount sufficient to cover the loss or damage of the cargo being transported. Carrier's cargo insurance policy must not exclude from coverage any commodities or cargo carried on this booking. If Carrier's cargo insurance policy contains a schedule of covered vehicles or equipment, Carrier will not transport any cargo on this booking using a vehicle and/or equipment that is not listed as scheduled on Carrier's cargo insurance policy.

PRO # 319908 FFREIGHT TEC F KC APOIN R FREIGHT TEC WWW.EPAYMANAGER.COM PO BOX 1349 BOUNTIFUL UT 84011-1349 Size & Type: 53' REEFER Pieces: * TEMP RANGE 45 TO 45 F * Blind Shipment CHARGES LINE HAUL RATE TOTAL RATE TYPE Cust Ref REFERENCE: SITTEONE BRIGHTON PICK 1 STOP 1 3400.00 3400.00 HOPPER BROS 33285 S BARLOW RD WOODBURN OR 97071 Phone/Contact: (503) 651-2493 SITEONE 23203 E 152ND AVE BRIGHTON CO Phone/Contact: (303) 690-8733 Rate Confirmation 05/05/22 16:42:28 (EST) M Α CARR- (208) 649-5023 (801) 298-1966 (f) kc@freight-tec.com TORCH TRANSPORTATION USA LLC (786) 761-1179 (p) Att: SEBASTIANS (786) 536-9093 (f) MC # | 983236 E DOT 2917388 R Driver FRANK Truck # 881649 Trailer # 12 Cell #3 (786) 970-3087 Description: NURSEYR STOCK Weight: 43500 Miles: DISPATCH NOTES MUST FOLLOW - DRIVER NEEDS TO CALL 48 HOURS IN ADVANCE FOR DELIVERY ARRANGEMENTS TO EACH STOP (NO CALL NO UNLOADING AND FEE WILL BE APPLIED ) DRIVER MUST HAVE 2-3 LOAD LOCKS TO SECURE LOAD. DRIVER MUST DOWNLOAD MACROPOINT for tracking * if not accepted fee of $250 APPLIED. Driver picking up a Load of Nursery: Load MUST be FULLY LOADED, if footage available must call for instructions TYPE REFERENCE Pick 1 SITEONE BRIGHTON REFERENCE Ready Date: 05/07/22 08:00 Ref # SITEONE BRIGHTON Appointment 05/09/22 Appt Notes: BLIND SHIPMENT Carrier above agree to promptly pickup & move this load to destination for the sum shown herein which includes all charges for such services, including, but not limited to LOADING, TRANSPORTING, UNLOADING & DELIVERING the freight tendered herein in the same condition as received from the Shipper without shortage, damage or delay. The above rate INCLUDES fuel surcharges & lumper fees. Directions supplied by Broker or its Customer either orally and/or in written form are for informational purposes only. It is the Carriers sole responsibility to confirm that it may lawfully operate a loaded vehicle of any weight, commodity or dimensions over any particular road, highwayad, highway, bridge, or or bridge or route. Carrier shall be solely responsible for any fines, penalties or citation occurring as a result of operating any vehicle over any road, highway, bridge or route in violation of any regulation, law or ordinance. Carrier shall defend indemnify & hold harmless Broker, its Shipper customer, the bill of lading parties from any claims, actions or damages arising out of the Carriers performance hereunder, including damages of any kind asserted against Broker for negligent hiring of Carrier, cargo loss and damage, theft, delay, damage to property & personal injury or death. Carrier will maintain no less than $1,000,000 of liability insurance & cargo NUMBER ABOVE WITH A VERBAL (Rate Confirmation Details on Next Page) Carrier Signature Date M D Send Carrier Bills to the Address Above PRO # 319908 must appear on all InvoicesPRO # 319908 FFREIGHT TEC F KC APOIN R Rate Confirmation 05/05/22 16:42:28 (EST) FREIGHT TEC WWW.EPAYMANAGER.COM PO BOX 1349 BOUNTIFUL UT 84011-1349 M Α CARR- (208) 649-5023 (801) 298-1966 (f) kc@freight-tec.com TORCH TRANSPORTATION USA LLC (786) 761-1179 (p) Att: SEBASTIANS (786) 536-9093 (f) MC # | 983236 E DOT 2917388 R Driver FRANK Truck # 881649 Trailer # 12 Cell #3 (786) 970-3087 CONFIRMATION OF DELIVERY. By accepting this load, Carrier acknowledges receipt of the Broker/Carrier Agreement, to which this Rate Confirmation applies, acknowledge that Carrier has read such Broker/Carrier Agreement & that Carrier agrees to & accepts each of the terms of the Broker/Carrier Agreement, without modification, which are hereby incorporated by reference as applicable to the above-described load, whether or not such Broker/Carrier Agreement, has been actually signed or not. Freight Tec as 'Broker' agrees to pay 'Carrier' within thirty (30) days after receipt of Carrier's paperwork into Epay Manager, which must include a signed copy of the complete/leigible shipper's BOL without any notation of damage, shortage or delay. By signing this Load/Rate Confirmation AGREEMENT, Carrier agrees to the terms & special SPECIFICATIONS ON PAGE 2 & subsequent pages, if any, hereof, Carrier Pickup & Delivery Schedule.Carrier or its agent certifies that any Transport Refrigeration Unit (TRU) equipment furnished for transport of perishable goods will be in compliance w/ the in-use requirements of California's TRU regulations. IF 'CARRIER' RE-BROKERS THIS LOAD TO ANOTHER CARRIER OR USES SUBSTITUTE SERVICES ON RAILROAD, 'BROKER' HAS THE RIGHT AT BROKER'S OPTION, TO CHARGE 'CARRIER' AS A PENALTY THE TOTAL AMOUNT DUE ON THIS RATE CONFIRMATION & NOT PAY CARRIER. PENALTY FOR LATE DELIVERY IS THE GREATER OF $200.00/DAY OR THE SHIPPERS ACTUAL LOSS FOR THE LATE DELIVERY. Driver must be able to communicate effectively in English. Carrier hereby grants permission to Broker to send periodic emails or faxes about our products & services. Carrier will abide by all Federal & State laws regarding safety & training for its drivers in the loading, transporting & unloading of the freight tendered to it by Shipper & will abide by all safety rules & regulations at the Shippers & Receivers facilities, including those at job sites. Unless you make a writen objection to the terms of this Rate Confirmation within one hour after receip, you have agreed to these terms. Carrier agrees to all Terms & Conditions listed at www.freight-tec.com. *IF AGREED SERVICES ARE NOT FULLFILLED , RATES ARE NEGOTIABLE.* If the Carrier is to be paid by Weight it is based up on DELIVERED WEIGHT as supported by weight tickets on all produce loads. Quantities quotes as a per rate per 50% bag shall mean a 50# EQUIVALENT BAG. If Carrier has incorrect #23 of pallets required, Carrier settlement pay will be reduced by the difference. If Shipper BOL shows a different temperature, Carrier is to use that temperature & follow all Shipper Specifications. Billing Instructions: Freight Tec pays carriers with FREE DIRECT DEPOSIT via epay. FAILURE TO ACCEPT MACROPOINT TRACKING WILL RESULT IN $100 FINE. IMPORTANT:WE WILL NOT ACCEPT PAPERWORK FOR PAYMENT PROCESSING 60 DAYS AFTER THE DELIVERY DATE. Please be aware that even if you submit within 60 days, a $50/day late paperwork fee may greatly reduce or even zero out your rate. Carrier Signature Date M D Send Carrier Bills to the Address Above PRO # 319908 must appear on all InvoicesBilling Instructions: Freight Tec pays carriers with FREE DIRECT DEPOSIT via epay. IMPORTANT: WE WILL NOT ACCEPT PAPERWORK FOR PAYMENT PROCESSING 60 DAYS AFTER THE DELIVERY DATE. Please be aware that even if you submit within 60 days, a $50/day late paperwork fee may greatly reduce or even zero out your rate. Please follow the instructions below to avoid these fees. Freight Tec's goal is to get us both paid as quick as possible. Thank you for your cooperation. FOR CARRIERS WHO USE A FACTORING COMPANY: You do NOT need to set up an Epay account. Your factoring company will complete the billing process for you through Epay. Please send your paperwork to your factoring company within 3 days. For Carriers who DO NOT use a Factoring Company: 1. Once your load is delivered in Freight Tec's system by the agent you are working with, you will receive an email from application@epaymanager.com 2. Click the green “Login to Epay” button in the email. (You can also access your account directly by going to www.epaymanager.com) Call 800-240-1824 if you need assistance logging into your account. 3. Click on "Receivables” then “Pending" on the left-side menu. Click on the green "I" box with the Freight Tec pro% (ref%) to the right. 4. Click on "Upload Documents" and upload your paperwork. 5. Click on the blue "View Invoice" link to return to the invoice page. (continued on next page)6. If you want quick pay, click on “Change Payment Terms" and select the quick pay option you want. 7. Click on "Accept Invoice." 8. You will have 36 hours to complete this process. If you do not complete this process in 36 hours, you may be charged a $50 per day late fee. (We don't want your money; we NEED the BOL fast.)

ROAR LOGISTICS Bill To Information HOU 535 EXCHANGE STREET BUFFALO, NY 14204 Phone: 7168337878 Fax: 7163320316 Email: accounting@roarlogistics.com Sent By: Email Abraham Campos acampos@roarlogistics.com Phone (281) 826-5752 Fax (281) 476-7763 Office HOU Rate/Route Confirmation for ARTURO TRUCKING LLC $4,000.00 Shipment Details Shipment # Cust Ref/PO # Todays Date Description of Merch: 1191475 870382850/4500929474 11/7/2023 14:29 BOL # Pallet Count Eq Type Eq ID 81166163 15 Van/Reefer - 53' 000000 TITANIUM DIOXIDE 15.00 PALLET @ 42410.00 Pounds Carrier Miles 2060 Temperature Carrier Details Carrier ARTURO TRUCKING LLC MC 1451407 DOT # SCAC 3922652 NA Driver Name Dispatch Phone Luis (702) 534-9584 (702) 285-6079 Dispatcher Carlos Fax Carrier Ref Stop Details Stop Type Pcs/Type/Wt 1 Pickup (Live) Address 1657 SWISCO ROAD SULPHUR, LA, 70665 PN: (337) 626-0674 CARBOLINE COMPANY Appt Date Appt Time PU/Delv # W502 VENATOR - USA Scheduled 11/7/23 07:30 15:30 ATTN: SHIPPING / RECEIVING 81166163 2 Delivery (Live) 95 AIRPARK VISTA BLVD DAYTON, NV, 89403 ATTN: ROSE Total Pcs: 15 PALLET PN: (775) 246-0760 Item # Charge Description 1 LINE HAUL Customer Note Pick W502 VENATOR - USA - Scheduled 11/10/23 08:00 15:00 3P0214316 Shipment Line Items Total Pallets: 15 Total Weight: 42410 lbs Carrier Rate Agreement Unit Price Unit Type $4,000.00 Flat Rate Unit Quantity 1 Total: Rate $4,000.00 $4,000.00 Note Shipment Notes - If booking Reefer, the trailer and truck must be able to scale gross weight, also dry, clean and odor-free. Tender may not reflect true weight and piece count. Driver must be able to handle the maximum legal limit. All shipment weights are subject to change and shipper reserves the right to ship max legal load without exceeding legal weights including axle weights. Exit 23 off I-10 Hwy 108 South to 2nd light turn right at light on SWISCO RD and 1 mile down on Swisco on the right is the VENATOR warehouse Tender may not reflect true weight and piece count. Driver must be able to handle the maximum legal limit. All shipment weights are subject to change and shipper reserves the right to ship max legal load without exceeding legal weights including axle weights. ARTURO TRUCKING LLC 11604 RUBINO ST, LAS VEGAS, NV (If this is not your information, notify dispatch immediately) Signature Date Terms of Agreement 1. **By signing this document, Carrier agrees to all terms and conditions listed in this load contract as well as the previously signed Carrier-Broker Agreement. In addition, carrier is acknowledging that they have read and understand all established terms and criteria for hauling this shipment. Should the carrier not submit a signed copy of this agreement back to ROAR, all terms and conditions are implied as accepted once the shipment has been signed for on the BOL by the carrier.** 2. *Please confirm receipt. Sign and return by E-mail to the "Sent By" E-mail indicated at the top of this document. // Failure to sign and/ or return constitutes acceptance of rate and terms. 3. *Drivers may NOT break seals without written authorization from ROAR Logistics. Unauthorized removal of seals may result in refusal of the shipment and a claim against your company.4. *When applicable, Carrier shall comply with the Federal Food, Drug, and Cosmetic Act ("FFDCA"), the Food Safety Modernization Act ("FSMA"), and the Sanitary Transportation of Human and Animal Food regulations. 5. *Accessorials and/or rate corrections must be reported at time of occurrence and documented with supporting paperwork to be honored. 6. *Please provide BOL/POD to ROAR within 48 hours of pick-up/delivery. 7. *It is agreed that ROAR Logistics Inc has the right of offset against any payment owed to the carrier in the matter of an unresolved claim that has not been settled. 8. *For Shipments In/Out of CA, carrier/driver must provide validation of CARB Compliance. 9. *Actual shipment reefer temperatures are NOT confirmed at time of load tender. ALL load/reefer temps must be validated by driver once checked-in at the shipping location, and validated with the BOL. Smart-reefers are required. 10. *Only smart/downloadable reefer units are to be used. Carrier must be able to produce a downloadable reefer report upon request. 11. *This document is confidential and not to be shared without permission of ROAR Logistics. 12. *Unless otherwise noted, this is a "Live" Load and/or Unload. ROAR Logistics will not honor additional charges associated with unauthorized drop trailers. Where applicable, carrier may be responsible for missed appointment fees if at fault. 13. *Payment to Lumper at time of delivery between 23:00-07:00 must be made by the driver/carrier. Payment can be reimbursed by request the next business day via Comcheck with a valid receipt. 14. *Any directions given by ROAR Logistics, Inc., or its Customers, whether orally and/or electronically, are for informational purposes only. It is the Carrier's sole responsibility to confirm that it may lawfully and safely operate its vehicle and its contents over any road, highway, bridge and/or route. Carrier shall be solely responsible for any fines, penalties, or citations that may be levied as a result of operating its vehicle equipment and its contents in any way that may be found to be in violation of any regulation, law or ordinance. 15. *For details on any/all Accessorial charges, please refer back to the ROAR Broker-to-Carrier Agreement signed by a representative from your (the carriers) organization. 16. *Driver is responsible to make sure seal is affixed to trailer and matches on the BOL. Failure to do so may result in driver having to return the load to the shipper and/or a claim filed for the entire load. 17. *Shipments of alcohol, in any concentration (%) or form: Carrier acknowledges it has the appropriate Insurance coverages and can provide, if necessary, the insurance policy noting that the type of alcohol being shipped on the rate confirmation sheet is "not an excluded commodity" and is covered by the carriers insurance policy. 18. *If SHIPPER Bill of Lading (BOL) states "PROTECT FROM FREEZING" and that was not implied by ROAR Logistics or is not stated on this document, please contact ROAR Logistics ASAP. 19. *When/where applicable, the carrier will be responsible for any/all early, late, and / or rescheduling fees (which could exceed $500+) on shipments delivering to a Walmart or Walmart owned facilities.

Internet is playing a more and more important role in today's society. Wireless network and mobile devices are becoming part of our lives. So it's significant to learn about information of the users or network usage for both network researchers and managers of fixed/wireless network. Previous methods of user characterizing and network usage are mostly based on TCP traffic study. But when facing to a large amount of users, raw packet capturing and storing would be difficult. Also, there were previous methods researched the fixed network or wireless network, but a comparative study is hardly seen. So in this paper, we measured the large-scale fixed and wireless network of our campus via DHCP analysis. We analyzed the user behavior such as distribution of user online time, user count and join/leave time-stamps. We also studied about users' operating systems by introducing DHCP OS fingerprinting. We found some interesting results, which revealed the trend of mobile network and some challenges might be brought in.

Multi-slice methods allow us to approximate the 3D phenomena without carrying out a full 3D analysis, e. g. in skewed radial flux electrical machines. The idea is to divide a 3D machine into several 2D FEM models, only connected by electrical circuits. Here we show how the multi-slice method is perfect for parallel computation; the computation efficiency is close to that of 2D models in modern parallel hardware. The results are shown to match with 3D computation and experimental results.

In this paper, we investigate the effectiveness of two-stage classification strategies in detecting north Atlantic right whale upcalls. Time-frequency measurements of data from passive acoustic monitoring devices are evaluated as images. Vocalization spectrograms are preprocessed for noise reduction and tone removal. First stage of the algorithm eliminates non-upcalls by an energy detection algorithm. In the second stage, two sets of features are extracted from the remaining signals using contour-based.and texture based methods. The former is based on-extraction of time-frequency features from upcall contours, and the latter employs a Local Binary Pattern operator to extract distinguishing texture features of the upcalls. Subsequently evaluation phase is carried out by using several classifiers to assess the effectiveness of both the contour-based and texture-based features for upcall detection. Comparing ROC curves of machine learning algorithms obtained from Cornell University's dataset reveals that LBP features improved performance accuracy up to 43% over time-frequency features. Classifiers such as the Linear Discriminant Analysis, Support Vector Machine, and TreeBagger achieve highest upcall detection rates with LBP features.(C) 2017 Elsevier Ltd. All rights reserved.

Search2 Carrier Details Transport PO BOX 356 SANDUSKY, OH 44871 Docket: MC1101784 Phone: (614) 432-8620 Fax: (614) 808-3598 LOAD CONFIRMATION Load # 115558839 Date 4/10/2023 Equipment Equipment Length 53 ft Reefer Full Weight Power Unit Trailer 32,000 lbs 15315 Jessica Dispatch Phone (954) 903-8472 Dispatch Email Dispatcher Carrier DELTA DOG TRUCKING Name MC # DOT # 1424270 3881574 Carrier SCAC Shipment Notes Carrier Notes: Reference deltadogtrucking@yahoo.com Driver Name Driver Cell Truck# (760) 485-3867 0811 Trailer# 15315 Trailer must be clean and odorless. Carrier is responsible for verifying load is safe and secure prior to departing shipper. Load locks required. Macropoint tracking is required. 45 Degrees Continuous. 9902A (Marietta) -Tail 9902B (Ellsworth) - Middle Tail 9902C (Morrow) - Middle 9902D (Norcross) - Middle Nose 9902E (Buford) - Nose 4-5 Pallets (Marietta) 3-4 Pallets (Ellsworth) 2-3 Pallets (Morrow) 4-5 Pallets (Norcross) 2-3 Pallets (Buford). Carrier must report any overages, shortages or damages prior to leaving each location. Please submit BOL immediately after delivery. Stops Details Action Location Contact Pickup Dennis's Potato Farm Inc 15370 Co Rd K WAUSEON, OH 43567 Primary Contact: Holly Phone: (419) 335-2778 Appt Date 4/10/2023 Appt Time 10:00 AM 5:00 PM PU / Delv # 9902 A. B. C. D. E Drop Rest. Depot - Marietta, GA Primary Contact: 4/11/2023 1:00 PM 1:00 PM 421-14342 1803 Roswell Rd Phone: +17709712800 Marietta, GA 30062 Drop Rest. Depot - Atlanta (Ellsworth) Primary Contact: 4/12/2023 8:00 AM 8:00 AM 166-69924 1455 Ellsworth Industrial Blvd NW Phone: +14043512501 Atlanta, GA 30318 Drop Rest. Depot - Morrow, GA 1245 Commerce Road Primary Contact: Receiving Phone: +16789627089 4/12/2023 9:30 AM 9:30 AM 428-46918 Morrow, GA 30260 Drop Rest. Depot - Norcross, GA Primary Contact: 4/12/2023 11:00 AM 11:00 AM 165-35561 6655 Crescent Dr Phone: +17704166490 Norcross, GA 30071 Delivery Rest. Depot Buford 4220 S Lee St Primary Contact: Phone: (678) 482-4650 4/12/2023 1:00 PM 1:00 PM 461-37867 Buford, GA 30518 Handling Units 20 Package Type Pallet Pieces 840 List of Items Palletized Potatoes Total Weight 32,000 Pay Items Fuel Linehaul Rate Confirmation Agreement for Search2Transport LLC. Total: $0.00 $2,600.00 $2,600.00Please call Search2Transport immediately with any issues (614) 432-8620. • Trailer must be clean and odorless prior to arrival at pickup location. • Carrier is responsible for verifying load is safe and secure prior to departing pickup location. Load locks are required. If there are any issues please call Search2Transport before departing the shipper. • This document can be used as a substitute for an invoice. If there are objections to the terms stated they must be submitted within 24 hours after receipt. • Rate shown includes any applicable fuel surcharges, pickup and delivery charges, loading and unloading, out of route, detention, storage, pallet charges and/or all arbitrary charges etc. Deviation from these rates must be approved in writing and signed by both parties. • Any authorized unloading will only be reimbursed with a valid unloading receipt. • If carrier is not using tracking, check calls must be made daily by 9 AM EST or carrier will be charged a penalty fee of $100 per day. • If pickup or delivery times are missed without prior notification to Search2Transport LLC, carrier will be subject to penalty charges of $250 per day. Additional late delivery charges assessed by the consignee may also apply. • In order to collect detention carrier must also notify Search2Transport LLC, within 2 hours after appointment time of any delays. Late pickups or late deliveries are not eligible for detention charges. If facility if FCFS, detention will only be paid if carrier is loaded or unloaded outside of the regular pick-up or delivery hours. If applicable, the arrival and departure times must be stamped and/or written on the BOL. Carrier must also be using any required tracking software to be eligible for detention pay. • • Driver is responsible for all load counts. If driver is not granted access to the loading dock they must call the broker to notify them immediately. Any directions given to the carrier are for informational purposes only. • Carrier acknowledges that they are solely responsible for compliance with all applicable HOS regulations, as well as all other FMCSA regulations. • No drivers are authorized to break seals under any circumstances. Seals must only be broken by the consignee's personnel. Loads delivered without the seals intact will result in fines and potential claims. • All trailers must be padlocked after each drop on consolidated loads. • Carrier agrees this shipment will not be re-brokered or said carrier forfeits the right to collect charges and agrees Search2Transport LLC, may pay charges directly to the underlying carrier to collect charges and agrees. • If delivering to California, carrier equipment must be CARB COMPLIANT. • Carrier representative submission with acceptance and signature indicates approval of all rates and terms listed on rate confirmation. Carrier must ensure load is safe and secure with load locks before departing. • Carrier must have sufficient hours to make delivery on time. Failure to have sufficient hours will result in late fees (Assuming the truck is loaded within 2 hours of arriving at each pickup). • If carrier has any overages, shortages, damages or rejections the carrier must notify Search2Transport LLC immediately before departing the shipper/receiver. • In the event of a layover the carrier will be paid $250.00. • In the event of a rejection/redelivery the carrier will be paid the same rate per mile as the initial run. Refrigerated Loads • All trailers must be pre-cooled to temp on arrival at loading facility. • All refrigerated loads must be run on continuous unless otherwise stated. • Data logger/temperature control unit is required equipment for all loads. • Driver must pulp product before leaving shipper. TRACKING ⋅ Tracking software is required on some loads tendered by Search2 Transport, LLC. If carrier is hauling a load that requires tracking, and driver fails to activate the technology, or driver disable the technology, or driver blocks tracking visibility in any way while the load is in the carriers possession, Search2Transport will fine the carrier $200 from the shipment for non-compliance. *****PLEASE SEND ALL INVOICES TO ACCOUNTING@SEARCH2TRANSPORT.COM OR FAX TO 614-808-3598 WITHIN 48 HOURS OF DELIVERY***** IF PAPERWORK IS NOT RECEIVED WITHIN 24 DAYS OF THE DELIVERY DATE, ANY UNLOADING FEES PAID BY THE CARRIER OR ACCESSORIAL CHARGES DUE TO THE CARRIER MAY BE REVOKED. ALL PAYMENT TERMS ARE BASED OFF THE DATE THE INVOICE AND PAPERWORK IS RECEIVED. Driver Name Print Name Driver Cell Phone # Signature Date