id stringlengths 5 8 | document_id stringlengths 8 8 | passages list | entities list | events list | coreferences list | relations list |
|---|---|---|---|---|---|---|
DS.d0 | 17003041 | [
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DS.d1 | 17321121 | [
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DS.d2 | 17403602 | [
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"When Vitreoscilla were grown in medium containing 60mM sodium nitrite under both normal and limited aeration conditions, the levels of Vitreoscilla hemoglobin (VHb) were decreased by greater than 90%, while the levels of the terminal respiratory oxidase, cytochrome bo, w... | [
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DS.d3 | 17590240 | [
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"Epigallocatechin gallate (EGCG) suppresses beta-amyloid-induced neurotoxicity through inhibiting c-Abl/FE65 nuclear translocation and GSK3 beta activation."
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... |
DS.d4 | 17616381 | [
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"The protease was purified to homogeneity using ammonium sulfate precipitation, and ion exchange chromatography with a fold purification of 1.8 and a recovery of 49%."
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... | [] | [] | [] |
DS.d5 | 17629591 | [
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"In addition, we demonstrated that Hsp20, HspB2 and HspB8 induced interleukin-6 production in cultured pericytes and astrocytes, which could be antagonized by dexamethasone, whereas other sHsps and A beta were inactive, suggesting that sHsps may be among the key mediators... | [
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DS.d6 | 17692997 | [
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DS.d7 | 17719144 | [
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"The scavenger receptor, class B, type I (SR-BI) is critical in maintaining the homeostasis of cholesterol and alpha-tocopherol."
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... |
DS.d8 | 17768029 | [
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"Alloxan is believed to confer its diabetogenic effect by inhibiting pancreatic glucokinase activity, leading to pancreatic beta-cell death."
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... | [] | [] | [
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DS.d9 | 17882129 | [
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"Alpha-tocopherol supplementation prevents the exercise-induced reduction of serum paraoxonase 1/arylesterase activities in healthy individuals."
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DS.d10 | 17888544 | [
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"Although ApoE4 has been repeatedly associated with altered sphingomyelin and cholesterol levels in tissue culture and rodent models, there has not been a direct quantification of sphingomyelin or sterol levels in the brains of patients with different forms of ApoE."
... | [
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DS.d11 | 17888546 | [
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... | [] | [] | [
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DS.d12 | 17890844 | [
{
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"text": [
"Here we show that during growth in media containing glucose and in complex medium without glucose RamB activates expression of the aceE gene, encoding the E1p subunit of the pyruvate dehydrogenase complex."
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... | [] | [] | [] |
DS.d13 | 17925795 | [
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"The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons."
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DS.d14 | 17941873 | [
{
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"text": [
"Addition of biphasic insulin aspart 30 to optimized metformin and pioglitazone treatment of type 2 diabetes mellitus: The ACTION Study (Achieving Control Through Insulin plus Oral ageNts)."
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DS.d15 | 17943458 | [
{
"id": "DS.d15.s0",
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"N-acetylaspartic acid (NAA) is converted into aspartate and acetate by aspartoacylase."
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DS.d16 | 17950491 | [
{
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"text": [
"In addition, treatment with rosiglitazone increased interleukin-4 (IL-4) mRNA and reversed the age-related decrease in hippocampal IL-4 concentration."
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DS.d17 | 17965987 | [
{
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"text": [
"Serum BDNF levels were increased and plasma levels of HVA and MHPG were decreased according to the recovery from the active phase of the disease."
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... | [] | [] | [] |
DS.d18 | 17968352 | [
{
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"text": [
"Based on these validities we identified alterations in the Wolframin gene in the CA1 and amygdala regions, specifically in exposed PTSD-like rats, which were normalized after treatment with citalopram."
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DS.d19 | 17968676 | [
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"text": [
"Cyclooxygenase-2 (Cox-2) is a key enzyme in the conversion of arachidonic acid to prostaglandins that has been shown to have a particular importance in the progression of several malignancies including nasopharyngeal carcinoma (NPC)."
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DS.d20 | 17976762 | [
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"text": [
"Other potential treatments discussed for possible use with long-acting insulin overdoses include incision and drainage of the injection site, glucagon, and octreotide."
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DS.d21 | 18037312 | [
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"Cadmium inhalation induced: (1) a transient bronchial inflammation, dominated by neutrophils; (2) a neutrophilia of the blood that persisted for up to 4 weeks; (3) a transient increased bronchial reactivity, and (4) a significant increase in MMP-9 activity in the BALF."... | [
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DS.d22 | 18042181 | [
{
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"To assess whether follicle-stimulating hormone (FSH) and basic fibroblast growth factor (bFGF) modulate GSH production in Sertoli cells by regulating the expression of GCLC, GCLM and/or GR, we performed in vitro studies using rat Sertoli cells in primary culture."
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DS.d23 | 18061671 | [
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"Compared to the control, both the stresses individually and in combination led to in reductions in growth, photosynthetic pigments, ascorbic acid, catalase (CAT) activity and yield, whereas a reverse trend was observed for flavonoids, thiols and proline contents, supero... | [
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DS.d24 | 18068270 | [
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"Selenium and aluminum levels were not associated to CSF Abeta42."
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DS.d39 | 18204887 | [
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DS.d40 | 18205042 | [
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DS.d42 | 18221806 | [
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DS.d45 | 18226951 | [
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},
{
"id": "DS.d47.s0.i1",
"type": "compound-protein-interaction",
"arg1_id": "DS.d47.s0.e1",
"arg2_id": "DS.d47.s0.e2",
"normalized": []... |
DS.d48 | 18227970 | [
{
"id": "DS.d48.s0",
"text": [
"In the root soluble fraction, the suicide inhibitor alpha-difluoromethyl-lysine suppressed the activity of lysine decarboxylase and of ornithine decarboxylase to the same extent, but had no effect on arginine decarboxylase activity."
],
"offsets": [
[
... | [
{
"id": "DS.d48.s0.e0",
"type": "compound",
"text": [
"difluoromethyl"
],
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[
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]
],
"normalized": [
{
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"db_id": "137670"
}
]
},
{
"id": "DS.d48.s0.e1",
"type": "compound",
... | [] | [] | [
{
"id": "DS.d48.s0.i2",
"type": "compound-protein-interaction",
"arg1_id": "DS.d48.s0.e0",
"arg2_id": "DS.d48.s0.e3",
"normalized": []
},
{
"id": "DS.d48.s0.i3",
"type": "compound-protein-interaction",
"arg1_id": "DS.d48.s0.e1",
"arg2_id": "DS.d48.s0.e3",
"normalized": []... |
DS.d49 | 18228136 | [
{
"id": "DS.d49.s0",
"text": [
"RT(2) Profiler PCR Array was used to identify differentially expressed genes in Dox and/or 2ME treatment groups, based on significance of results 4 genes were selected: MDR1, Bcl2, P53 and Cyclin D1."
],
"offsets": [
[
0,
199
]
],... | [
{
"id": "DS.d49.s0.e0",
"type": "compound",
"text": [
"2ME"
],
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[
91,
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]
],
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{
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"db_id": "10903"
}
]
},
{
"id": "DS.d49.s0.e1",
"type": "protein",
"text": [... | [] | [] | [
{
"id": "DS.d49.s0.i0",
"type": "compound-protein-interaction",
"arg1_id": "DS.d49.s0.e0",
"arg2_id": "DS.d49.s0.e4",
"normalized": []
},
{
"id": "DS.d49.s0.i1",
"type": "compound-protein-interaction",
"arg1_id": "DS.d49.s0.e0",
"arg2_id": "DS.d49.s0.e3",
"normalized": []... |
DS.d50 | 18230627 | [
{
"id": "DS.d50.s0",
"text": [
"Randomised trials have demonstrated that the efficacy of anti-tumour necrosis factor (TNF) agents is significantly increased by concomitant methotrexate (MTX) in rheumatoid arthritis (RA)."
],
"offsets": [
[
0,
188
]
],
"type"... | [
{
"id": "DS.d50.s0.e0",
"type": "protein",
"text": [
"TNF"
],
"offsets": [
[
86,
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]
],
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{
"db_name": "UniProt",
"db_id": "O35734"
},
{
"db_name": "UniProt",
"db_id": "O77510"
},
... | [] | [] | [
{
"id": "DS.d50.s0.i0",
"type": "compound-protein-interaction",
"arg1_id": "DS.d50.s0.e1",
"arg2_id": "DS.d50.s0.e0",
"normalized": []
}
] |
DS.d51 | 18243311 | [
{
"id": "DS.d51.s0",
"text": [
"Neither apyrase nor ATP altered production of reactive oxygen intermediates (ROI) or reactive nitrogen intermediates (RNI) by bovine monocytes."
],
"offsets": [
[
0,
143
]
],
"type": ""
}
] | [
{
"id": "DS.d51.s0.e0",
"type": "protein",
"text": [
"apyrase"
],
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[
8,
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]
],
"normalized": [
{
"db_name": "UniProt",
"db_id": "P52914"
}
]
},
{
"id": "DS.d51.s0.e1",
"type": "compound",
"text... | [] | [] | [] |
DS.d52 | 18243368 | [
{
"id": "DS.d52.s0",
"text": [
"In this systematic review, we have analyzed the results of 52 clinical trials, including 72 intervention groups and 6290 patients, on vitamin D supplementation in order to evaluate the experimental evidence and the effects of age and chronic immobility on responses of p... | [
{
"id": "DS.d52.s0.e0",
"type": "compound",
"text": [
"vitamin D"
],
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[
134,
143
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],
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{
"db_name": "PubChem",
"db_id": "5280795"
}
]
},
{
"id": "DS.d52.s0.e1",
"type": "protein",
... | [] | [] | [
{
"id": "DS.d52.s0.i0",
"type": "compound-protein-interaction",
"arg1_id": "DS.d52.s0.e0",
"arg2_id": "DS.d52.s0.e1",
"normalized": []
},
{
"id": "DS.d52.s1.i0",
"type": "compound-protein-interaction",
"arg1_id": "DS.d52.s1.e0",
"arg2_id": "DS.d52.s1.e1",
"normalized": []... |
DS.d53 | 18248398 | [
{
"id": "DS.d53.s0",
"text": [
"Leptin did not show any effect in long photoperiod but decreased proliferation by stimulating melatonin in short photoperiod."
],
"offsets": [
[
0,
125
]
],
"type": ""
}
] | [
{
"id": "DS.d53.s0.e0",
"type": "protein",
"text": [
"Leptin"
],
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[
0,
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]
],
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{
"db_name": "UniProt",
"db_id": "O02750"
},
{
"db_name": "UniProt",
"db_id": "O93416"
},
... | [] | [] | [
{
"id": "DS.d53.s0.i0",
"type": "compound-protein-interaction",
"arg1_id": "DS.d53.s0.e1",
"arg2_id": "DS.d53.s0.e0",
"normalized": []
}
] |
DS.d54 | 18249383 | [
{
"id": "DS.d54.s0",
"text": [
"To compare the changes in body composition and in leptin levels in postmenopausal women receiving hormone therapy (HT) or tibolone."
],
"offsets": [
[
0,
131
]
],
"type": ""
}
] | [
{
"id": "DS.d54.s0.e0",
"type": "protein",
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"leptin"
],
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[
50,
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]
],
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{
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"db_id": "O02750"
},
{
"db_name": "UniProt",
"db_id": "O93416"
},
... | [] | [] | [
{
"id": "DS.d54.s0.i0",
"type": "compound-protein-interaction",
"arg1_id": "DS.d54.s0.e1",
"arg2_id": "DS.d54.s0.e0",
"normalized": []
}
] |
DS.d55 | 18249399 | [
{
"id": "DS.d55.s0",
"text": [
"Common 677C-->T mutation of the 5,10-methylenetetrahydrofolate reductase gene affects follicular estradiol synthesis."
],
"offsets": [
[
0,
120
]
],
"type": ""
}
] | [
{
"id": "DS.d55.s0.e0",
"type": "protein",
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"5,10-methylenetetrahydrofolate reductase"
],
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35,
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]
],
"normalized": [
{
"db_name": "UniProt",
"db_id": "O54235"
},
{
"db_name": "UniProt",
... | [] | [] | [
{
"id": "DS.d55.s0.i0",
"type": "compound-protein-interaction",
"arg1_id": "DS.d55.s0.e1",
"arg2_id": "DS.d55.s0.e0",
"normalized": []
}
] |
DS.d56 | 18253022 | [
{
"id": "DS.d56.s0",
"text": [
"Surprisingly, a deletion of the pilR gene affected not only insoluble Fe(III) reduction, which requires pili, but also soluble Fe(III) reduction, which, in contrast, does not require pili."
],
"offsets": [
[
0,
188
]
],
"type"... | [
{
"id": "DS.d56.s0.e0",
"type": "protein",
"text": [
"pilR"
],
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[
32,
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]
],
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"db_id": "Q00934"
}
]
},
{
"id": "DS.d56.s0.e1",
"type": "compound",
"text":... | [] | [] | [
{
"id": "DS.d56.s0.i0",
"type": "compound-protein-interaction",
"arg1_id": "DS.d56.s0.e1",
"arg2_id": "DS.d56.s0.e0",
"normalized": []
}
] |
DS.d57 | 18253697 | [
{
"id": "DS.d57.s0",
"text": [
"Furthermore, the suppressive effects of P on cytochrome c release and caspase-9 and caspase-3 activation in serum-deprived MC3T3-E1 cells were also reversed by RU486."
],
"offsets": [
[
0,
166
]
],
"type": ""
}
] | [
{
"id": "DS.d57.s0.e0",
"type": "protein",
"text": [
"cytochrome c"
],
"offsets": [
[
45,
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]
],
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{
"db_name": "UniProt",
"db_id": "O07091"
},
{
"db_name": "UniProt",
"db_id": "O13393"
... | [] | [] | [
{
"id": "DS.d57.s0.i0",
"type": "compound-protein-interaction",
"arg1_id": "DS.d57.s0.e1",
"arg2_id": "DS.d57.s0.e0",
"normalized": []
}
] |
DS.d58 | 18256928 | [
{
"id": "DS.d58.s0",
"text": [
"Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERalpha negative MDA-MB-435 breast cancer model."
],
"offsets": [
[
0,
127
]
],
"type": ""
},
{
"id": "DS.d58.s1",
"text": [
"How... | [
{
"id": "DS.d58.s0.e0",
"type": "compound",
"text": [
"metformin"
],
"offsets": [
[
12,
21
]
],
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{
"db_name": "PubChem",
"db_id": "4091"
}
]
},
{
"id": "DS.d58.s0.e1",
"type": "protein",
"tex... | [] | [] | [
{
"id": "DS.d58.s0.i0",
"type": "compound-protein-interaction",
"arg1_id": "DS.d58.s0.e0",
"arg2_id": "DS.d58.s0.e1",
"normalized": []
},
{
"id": "DS.d58.s1.i0",
"type": "compound-protein-interaction",
"arg1_id": "DS.d58.s1.e0",
"arg2_id": "DS.d58.s1.e2",
"normalized": []... |
DS.d59 | 18260130 | [
{
"id": "DS.d59.s0",
"text": [
"TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacr... | [
{
"id": "DS.d59.s0.e0",
"type": "protein",
"text": [
"TNF-alpha"
],
"offsets": [
[
0,
9
]
],
"normalized": [
{
"db_name": "UniProt",
"db_id": "O35734"
},
{
"db_name": "UniProt",
"db_id": "O77510"
},... | [] | [] | [] |
DS.d60 | 18262559 | [
{
"id": "DS.d60.s0",
"text": [
"Systemic administration of hemoglobin vesicle elevates tumor tissue oxygen tension and modifies tumor response to irradiation."
],
"offsets": [
[
0,
126
]
],
"type": ""
}
] | [
{
"id": "DS.d60.s0.e0",
"type": "protein",
"text": [
"hemoglobin"
],
"offsets": [
[
27,
37
]
],
"normalized": [
{
"db_name": "UniProt",
"db_id": "P15160"
},
{
"db_name": "UniProt",
"db_id": "P17724"
... | [] | [] | [
{
"id": "DS.d60.s0.i0",
"type": "compound-protein-interaction",
"arg1_id": "DS.d60.s0.e1",
"arg2_id": "DS.d60.s0.e0",
"normalized": []
}
] |
DS.d61 | 18262738 | [
{
"id": "DS.d61.s0",
"text": [
"The participation of protein kinase A (PKA), protein kinase C (PKC) and protein tyrosine kinase (PTK) in capacitation induced by ONOO (-) was evaluated by incubation with specific inhibitors (50 microM H-89, 0.1 microM bisindolylmaleimide I, and 3 microM genistein, resp... | [
{
"id": "DS.d61.s0.e0",
"type": "protein",
"text": [
"protein kinase A"
],
"offsets": [
[
21,
37
]
],
"normalized": [
{
"db_name": "UniProt",
"db_id": "Q05608"
},
{
"db_name": "UniProt",
"db_id": "Q9RI12"... | [] | [] | [] |
DS.d62 | 18266054 | [
{
"id": "DS.d62.s0",
"text": [
"At the time, glutathione reductase activity was significantly inhibited and gamma-glutamyl cysteine increased by ACA exposure."
],
"offsets": [
[
0,
126
]
],
"type": ""
}
] | [
{
"id": "DS.d62.s0.e0",
"type": "protein",
"text": [
"glutathione reductase"
],
"offsets": [
[
13,
34
]
],
"normalized": [
{
"db_name": "UniProt",
"db_id": "O15770"
},
{
"db_name": "UniProt",
"db_id": "P0... | [] | [] | [] |
DS.d63 | 18268501 | [
{
"id": "DS.d63.s0",
"text": [
"The effect of the polymorphism is non-conservative and results in a glutamine to arginine change (Gln460Arg), which is likely to affect P2RX7 dimerization and protein-protein interactions."
],
"offsets": [
[
0,
188
]
],
"type"... | [
{
"id": "DS.d63.s0.e0",
"type": "compound",
"text": [
"glutamine"
],
"offsets": [
[
68,
77
]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "738"
},
{
"db_name": "PubChem",
"db_id": "5961"
}
... | [] | [] | [
{
"id": "DS.d63.s0.i0",
"type": "compound-protein-interaction",
"arg1_id": "DS.d63.s0.e1",
"arg2_id": "DS.d63.s0.e2",
"normalized": []
},
{
"id": "DS.d63.s0.i1",
"type": "compound-protein-interaction",
"arg1_id": "DS.d63.s0.e0",
"arg2_id": "DS.d63.s0.e2",
"normalized": []... |
DS.d64 | 18270841 | [
{
"id": "DS.d64.s0",
"text": [
"Increased somatostatin tone and decreased ghrelin concentrations may also contribute to reduced GH levels."
],
"offsets": [
[
0,
106
]
],
"type": ""
}
] | [
{
"id": "DS.d64.s0.e0",
"type": "compound",
"text": [
"somatostatin"
],
"offsets": [
[
10,
22
]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "16129681"
},
{
"db_name": "PubChem",
"db_id": "16129706... | [] | [] | [] |
DS.d65 | 18272254 | [
{
"id": "DS.d65.s0",
"text": [
"Inhibition of LTP by beta-amyloid is prevented by activation of beta2 adrenoceptors and stimulation of the cAMP/PKA signalling pathway."
],
"offsets": [
[
0,
135
]
],
"type": ""
}
] | [
{
"id": "DS.d65.s0.e0",
"type": "protein",
"text": [
"beta2 adrenoceptors"
],
"offsets": [
[
64,
83
]
],
"normalized": [
{
"db_name": "UniProt",
"db_id": "O70431"
},
{
"db_name": "UniProt",
"db_id": "P042... | [] | [] | [] |
DS.d66 | 18274872 | [
{
"id": "DS.d66.s0",
"text": [
") O2 (-) and H2O2 in H. plumaeforme was respectively related to the low activity of SOD and the decreased activity of CAT."
],
"offsets": [
[
0,
122
]
],
"type": ""
}
] | [
{
"id": "DS.d66.s0.e0",
"type": "compound",
"text": [
"O2"
],
"offsets": [
[
2,
4
]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "977"
},
{
"db_name": "PubChem",
"db_id": "5359597"
}
]
... | [] | [] | [
{
"id": "DS.d66.s0.i0",
"type": "compound-protein-interaction",
"arg1_id": "DS.d66.s0.e0",
"arg2_id": "DS.d66.s0.e2",
"normalized": []
},
{
"id": "DS.d66.s0.i1",
"type": "compound-protein-interaction",
"arg1_id": "DS.d66.s0.e1",
"arg2_id": "DS.d66.s0.e3",
"normalized": []... |
End of preview. Expand
in Data Studio
Dataset Card for CPI
The compound-protein relationship (CPI) dataset consists of 2,613 sentences from abstracts containing annotations of proteins, small molecules, and their relationships.
Citation Information
@article{doring2020automated,
title={Automated recognition of functional compound-protein relationships in literature},
author={D{\"o}ring, Kersten and Qaseem, Ammar and Becer, Michael and Li, Jianyu and Mishra, Pankaj and Gao, Mingjie and Kirchner, Pascal and Sauter, Florian and Telukunta, Kiran K and Moumbock, Aur{\'e}lien FA and others},
journal={Plos one},
volume={15},
number={3},
pages={e0220925},
year={2020},
publisher={Public Library of Science San Francisco, CA USA}
}
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